[ { "uniprot_canonical_ac": "A0AAA9S4B4-1", "uniprot_ac": "A0AAA9S4B4", "uniprot_id": "A0AAA9S4B4_BOVIN", "mass": { "chemical_mass": 35235.0, "monoisotopic_mass": 35235.0 }, "refseq": { "ac": "NP_001377695", "name": "olfactory receptor 51E1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377695" }, "gene_names": [ { "name": "OR51E1", "type": "recommended", "evidence": [ { "id": "A0AAA9S4B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" } ] }, { "name": "OR51E1", "type": "synonym", "evidence": [ { "id": "NP_001377695", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377695" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S4B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 51E1", "type": "synonym", "evidence": [ { "id": "NP_001377695", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377695" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377695" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4", "locus": { "chromosome": "15", "start_pos": 50380767, "end_pos": 50406272, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064914", "url": "https://www.ensembl.org/id/ENSBTAG00000064914" } ] } } ], "crossref": [ { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112441493", "url": "https://www.ncbi.nlm.nih.gov/gene/112441493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112441493", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441493", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VQMFAIH", "url": "https://omabrowser.org/oma/group/VQMFAIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377695", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4B4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHSLHEPMYIFLCMLSGLDVLISTSSMPKMMAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVTKIGMAAVVRGVALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIHVNIIYGLIVIISAIGLDSLLISLSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFGKQHDSLLPVILANTYLLVPPVLNPIVYGVKTKEIRQRILRLFHVTTHTLDP", "length": 317, "header": "tr|A0AAA9S4B4-1|A0AAA9S4B4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51E1 PE=3 SV=1 CANONICAL=A0AAA9S4B4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4B4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4/entry#A0AAA9S4B4-1", "sequence": { "sequence": "MVGPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHSLHEPMYIFLCMLSGLDVLISTSSMPKMMAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVTKIGMAAVVRGVALMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIHVNIIYGLIVIISAIGLDSLLISLSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFGKQHDSLLPVILANTYLLVPPVLNPIVYGVKTKEIRQRILRLFHVTTHTLDP", "length": 317, "header": "tr|A0AAA9S4B4-1|A0AAA9S4B4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51E1 PE=3 SV=1 CANONICAL=A0AAA9S4B4-1" }, "locus": { "chromosome": "15", "start_pos": 50385906, "end_pos": 50384956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113718.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113718.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081373.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112441493", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441493", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8TCB6-1", "protein_name": "Olfactory receptor 51E1", "gene_name": "OR51E1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMVDPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHSLHEPMYIFLCMLSGIDILISTSSMPKMLAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVTKIGVAAVVRGAALMAPLPVFIKQLPFCRSNILSHSYCLHQDVMKLACDDIRVNVVYGLIVIISAIGLDSLLISFSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRRDSPLPVILANIYLLVPPVLNPIVYGVKTKEIRQRILRLFHVATHASEP", "length": 318 }, "evidence": [ { "id": "A0AAA9S4B4", "url": "https://omabrowser.org/oma/group/A0AAA9S4B4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VGZ7-1", "protein_name": "Olfactory receptor", "gene_name": "Or51e1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGFNSNESSATYFILIGLPGLEEVQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHSLHEPMYIFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDACLVQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVAKIGMAAVVRGAVLMAPLPVFIKRLPFCRSNILSHSYCLHQDVMKLACADIRVNIIYGLIVIISAIGLDSLLISFSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRRDSLLPVIMANIYLLVPPVLNPIVYGVKTKEIRQRILRLFLVTTHTSDH", "length": 317 }, "evidence": [ { "id": "A0AAA9S4B4", "url": "https://omabrowser.org/oma/group/A0AAA9S4B4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4B4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 293, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 44, "end_pos": 46 }, { "start_pos": 7, "end_pos": 9 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4D1-1", "uniprot_ac": "A0AAA9S4D1", "uniprot_id": "A0AAA9S4D1_BOVIN", "mass": { "chemical_mass": 49596.0, "monoisotopic_mass": 49596.0 }, "refseq": { "ac": "XP_005202730", "name": "flagellum-associated coiled-coil domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202730" }, "gene_names": [ { "name": "FLACC1", "type": "recommended", "evidence": [ { "id": "A0AAA9S4D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1" } ] }, { "name": "FLACC1", "type": "synonym", "evidence": [ { "id": "XP_005202730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202730" } ] } ], "protein_names": [ { "name": "Flagellum associated containing coiled-coil domains 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S4D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1/entry#names_and_taxonomy" } ] }, { "name": "flagellum-associated coiled-coil domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202730", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202730" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FLACC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1", "locus": { "chromosome": "2", "start_pos": 89886536, "end_pos": 89924382, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012334", "url": "https://www.ensembl.org/id/ENSBTAG00000012334" } ] } } ], "crossref": [ { "id": "A0AAA9S4D1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4D1", "database": "AlphaFoldDB", "categories": [] }, { "id": "784225", "url": "https://www.ncbi.nlm.nih.gov/gene/784225", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21707", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21707", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21707:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21707:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005202730", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202730", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYPNPLVYCTCWDPWNLGPRKLIKTPQPPSKTSSVKPKLSPLPPAGKKQNYAQLITKPVVSPKMKVHLGKQEESNKLPNEVINVSPGYCLIRNREQISVTLGDEMFDRKKHSESEDVGKVKISRTDIIADLKEQISELTVIIEQMNRDHRSAQKLLSNEMDLRCAEMQKNFESKTRELEEAHAAQLSELEKNYKAALKAEKLAAQDKLEEMGKEYKYLKNMFHIYQDSIYDEMEDKWSKKKAEWEKDEKLERERILLQQKHKITRKFELESEEERKKINESYTAIFENFNQEKEELLKQHERDTLQLEELRKTKEVIEEELYAQALILESLNTTLYQTQMELQREKAVVATLEKTLQIKLTEAEDKFKYTIHNLTEENIHLRQKIIAKNEEIYDERFGRSTSVTVYEHNSDTLEDGGNETQE", "length": 422, "header": "tr|A0AAA9S4D1-1|A0AAA9S4D1_BOVIN Isoform 1 of Flagellum associated containing coiled-coil domains 1 OS=Bos taurus OX=9913 GN=FLACC1 PE=4 SV=1 CANONICAL=A0AAA9S4D1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D1/entry#A0AAA9S4D1-1", "sequence": { "sequence": "MYPNPLVYCTCWDPWNLGPRKLIKTPQPPSKTSSVKPKLSPLPPAGKKQNYAQLITKPVVSPKMKVHLGKQEESNKLPNEVINVSPGYCLIRNREQISVTLGDEMFDRKKHSESEDVGKVKISRTDIIADLKEQISELTVIIEQMNRDHRSAQKLLSNEMDLRCAEMQKNFESKTRELEEAHAAQLSELEKNYKAALKAEKLAAQDKLEEMGKEYKYLKNMFHIYQDSIYDEMEDKWSKKKAEWEKDEKLERERILLQQKHKITRKFELESEEERKKINESYTAIFENFNQEKEELLKQHERDTLQLEELRKTKEVIEEELYAQALILESLNTTLYQTQMELQREKAVVATLEKTLQIKLTEAEDKFKYTIHNLTEENIHLRQKIIAKNEEIYDERFGRSTSVTVYEHNSDTLEDGGNETQE", "length": 422, "header": "tr|A0AAA9S4D1-1|A0AAA9S4D1_BOVIN Isoform 1 of Flagellum associated containing coiled-coil domains 1 OS=Bos taurus OX=9913 GN=FLACC1 PE=4 SV=1 CANONICAL=A0AAA9S4D1-1" }, "locus": { "chromosome": "2", "start_pos": 89917272, "end_pos": 89886543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109441.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109441.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080794.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 279, "end_pos": 281 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 373, "end_pos": 375 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4D5-1", "uniprot_ac": "A0AAA9S4D5", "uniprot_id": "A0AAA9S4D5_BOVIN", "mass": { "chemical_mass": 26571.0, "monoisotopic_mass": 26571.0 }, "refseq": {}, "gene_names": [ { "name": "PEX11B", "type": "recommended", "evidence": [ { "id": "A0AAA9S4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ] } ], "protein_names": [ { "name": "Peroxisomal biosis factor 11 beta", "type": "synonym", "evidence": [ { "id": "A0AAA9S4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PEX11B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5", "locus": { "chromosome": "3", "start_pos": 21459694, "end_pos": 21453990, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008372", "url": "https://www.ensembl.org/id/ENSBTAG00000008372" } ] } } ], "crossref": [ { "id": "A0AAA9S4D5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12652:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12652:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKLRAAQYACSLLGHALQKHGASPELQKQIRQLEGHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGVSGGIEPGGPGGPGIPGGGLPQVALKLRLRVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLICPWLRLKP", "length": 244, "header": "tr|A0AAA9S4D5-1|A0AAA9S4D5_BOVIN Isoform 1 of Peroxisomal biosis factor 11 beta OS=Bos taurus OX=9913 GN=PEX11B PE=4 SV=1 CANONICAL=A0AAA9S4D5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5/entry#A0AAA9S4D5-1", "sequence": { "sequence": "MGKLRAAQYACSLLGHALQKHGASPELQKQIRQLEGHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGVSGGIEPGGPGGPGIPGGGLPQVALKLRLRVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLICPWLRLKP", "length": 244, "header": "tr|A0AAA9S4D5-1|A0AAA9S4D5_BOVIN Isoform 1 of Peroxisomal biosis factor 11 beta OS=Bos taurus OX=9913 GN=PEX11B PE=4 SV=1 CANONICAL=A0AAA9S4D5-1" }, "locus": { "chromosome": "3", "start_pos": 21458890, "end_pos": 21454366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093519.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093519.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076990.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076990.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "peroxisome fission", "id": "GO:0016559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016559", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "pmid": "" }, { "name": "regulation of peroxisome size", "id": "GO:0044375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044375", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4D6-1", "uniprot_ac": "A0AAA9S4D6", "uniprot_id": "A0AAA9S4D6_BOVIN", "mass": { "chemical_mass": 29545.0, "monoisotopic_mass": 29545.0 }, "refseq": { "ac": "XP_005207733", "name": "tropomyosin alpha-3 chain-like isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207733" }, "gene_names": [ { "name": "LOC101904481", "type": "recommended", "evidence": [ { "id": "A0AAA9S4D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6" } ] }, { "name": "LOC101904481", "type": "synonym", "evidence": [ { "id": "XP_005207733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207733" } ] } ], "protein_names": [ { "name": "Tropomyosin alpha-4 chain", "type": "recommended", "evidence": [ { "id": "A0AAA9S4D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6/entry#names_and_taxonomy" } ] }, { "name": "Tropomyosin-4", "type": "synonym", "evidence": [ { "id": "A0AAA9S4D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6/entry#names_and_taxonomy" } ] }, { "name": "tropomyosin alpha-3 chain-like isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005207733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207733" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101904481", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6", "locus": {} } ], "crossref": [ { "id": "101904481", "url": "https://www.ncbi.nlm.nih.gov/gene/101904481", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101904481", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904481", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR19269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00261", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00261", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005207733", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207733", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGTTVMAAIAVTEAMKCKIQVLQQQADDAEERAKRLQQKVDGERWAREQAEAEVVSLNRRIQLVEEELNRAQERLATALQKLEEAEKAADESERVMKVIENQALKDEEKMELQEIQLKEAKHIAEEAHRKYEEVARKLVIIEGDLERTEERAELAQSRCRKMGEQIRLMDQHLKCLSAAEEKYSQKEDKYEEEIKILTEKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEDLCTQRMLNQTLLDLNKM", "length": 254, "header": "tr|A0AAA9S4D6-1|A0AAA9S4D6_BOVIN Isoform 1 of Tropomyosin alpha-4 chain OS=Bos taurus OX=9913 GN=LOC101904481 PE=3 SV=1 CANONICAL=A0AAA9S4D6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6/entry#A0AAA9S4D6-1", "sequence": { "sequence": "MAGTTVMAAIAVTEAMKCKIQVLQQQADDAEERAKRLQQKVDGERWAREQAEAEVVSLNRRIQLVEEELNRAQERLATALQKLEEAEKAADESERVMKVIENQALKDEEKMELQEIQLKEAKHIAEEAHRKYEEVARKLVIIEGDLERTEERAELAQSRCRKMGEQIRLMDQHLKCLSAAEEKYSQKEDKYEEEIKILTEKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEDLCTQRMLNQTLLDLNKM", "length": 254, "header": "tr|A0AAA9S4D6-1|A0AAA9S4D6_BOVIN Isoform 1 of Tropomyosin alpha-4 chain OS=Bos taurus OX=9913 GN=LOC101904481 PE=3 SV=1 CANONICAL=A0AAA9S4D6-1" }, "locus": { "chromosome": "6", "start_pos": 19140741, "end_pos": 19139980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126535.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126535.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098304.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101904481", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904481", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4D6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4F3-1", "uniprot_ac": "A0AAA9S4F3", "uniprot_id": "A0AAA9S4F3_BOVIN", "mass": { "chemical_mass": 38730.0, "monoisotopic_mass": 38730.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101902838", "type": "recommended", "evidence": [ { "id": "A0AAA9S4F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" } ] } ], "protein_names": [ { "name": "Zinc finger protein 75D", "type": "recommended", "evidence": [ { "id": "A0AAA9S4F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101902838", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3", "locus": {} } ], "crossref": [ { "id": "A0AAA9S4F3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4F3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPVKAPACLYPHVEVLQGTKRSVKESSNKSKKSSPQMGSLHPDSARQHFRRFCYHDTPGPYEAVSQLQELCSQWLRPEIHSKEQILELLVLEQFLDVLPSHIQNWVQKYHPQNVKEAVALVDRFQRECGGISNEVTTHQLGNDTALLGGTAVAPGFKWKPAEPQQMGVFQEECSNIYQVLQDPDWNTHKESQPVDKGAVPAEESPTFSEEKSTPSWKLASKLTLPKSQSPLTFEDVAFYFSEEEWKIMTPDEKTLYLDVMQELYEDVASVGLKLKNDTGNDPPVSLPTLEIQPSGCEVLGKAAMKDAETTVGNENHGDTCRVRKRPRSPEAPALASHFVPGDELH", "length": 346, "header": "tr|A0AAA9S4F3-1|A0AAA9S4F3_BOVIN Isoform 1 of Zinc finger protein 75D OS=Bos taurus OX=9913 GN=LOC101902838 PE=4 SV=2 CANONICAL=A0AAA9S4F3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3/entry#A0AAA9S4F3-1", "sequence": { "sequence": "MSPVKAPACLYPHVEVLQGTKRSVKESSNKSKKSSPQMGSLHPDSARQHFRRFCYHDTPGPYEAVSQLQELCSQWLRPEIHSKEQILELLVLEQFLDVLPSHIQNWVQKYHPQNVKEAVALVDRFQRECGGISNEVTTHQLGNDTALLGGTAVAPGFKWKPAEPQQMGVFQEECSNIYQVLQDPDWNTHKESQPVDKGAVPAEESPTFSEEKSTPSWKLASKLTLPKSQSPLTFEDVAFYFSEEEWKIMTPDEKTLYLDVMQELYEDVASVGLKLKNDTGNDPPVSLPTLEIQPSGCEVLGKAAMKDAETTVGNENHGDTCRVRKRPRSPEAPALASHFVPGDELH", "length": 346, "header": "tr|A0AAA9S4F3-1|A0AAA9S4F3_BOVIN Isoform 1 of Zinc finger protein 75D OS=Bos taurus OX=9913 GN=LOC101902838 PE=4 SV=2 CANONICAL=A0AAA9S4F3-1" }, "locus": { "chromosome": "X", "start_pos": 19022379, "end_pos": 19013647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115637.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115637.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078690.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078690.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 232, "end_pos": 313, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S4F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4F3" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 128, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 29, "end_pos": 31 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5C5-1", "uniprot_ac": "A0AAA9S5C5", "uniprot_id": "A0AAA9S5C5_BOVIN", "mass": { "chemical_mass": 31377.0, "monoisotopic_mass": 31377.0 }, "refseq": {}, "gene_names": [ { "name": "NSL1", "type": "recommended", "evidence": [ { "id": "A0AAA9S5C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5" } ] } ], "protein_names": [ { "name": "NSL1 component of MIS12 kinetochore complex", "type": "synonym", "evidence": [ { "id": "A0AAA9S5C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NSL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5", "locus": { "chromosome": "16", "start_pos": 70806428, "end_pos": 70703959, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011340", "url": "https://www.ensembl.org/id/ENSBTAG00000011340" } ] } } ], "crossref": [ { "id": "A0AAA9S5C5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5C5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31749", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31749", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31749:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31749:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08641", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08641", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVTVHQPYAHRPHHSSHRNPWTRRRSHSRNASAAVGSISGRTCAPSSRETRPSALRIPAQSSSWKYGAGPQTFESAVQENVSINGQAWQEASDDCFMDSDIKVLEDQFDEIIVDLATKRKQYPRKILEYVIKIIKAQQEILKQYHPVVHLLDLKYDPDPAPRLENLRCRGGAVAKEISEAMKSLPALIEQGDGFSQVLKMQPIIQLQRVHQEVFSSCCRKPDVKPESFIAQIETTPAETSTRTATDLVLRRKRTKDCPQRKWYPLRRKRINLDT", "length": 275, "header": "tr|A0AAA9S5C5-1|A0AAA9S5C5_BOVIN Isoform 1 of NSL1 component of MIS12 kinetochore complex OS=Bos taurus OX=9913 GN=NSL1 PE=4 SV=1 CANONICAL=A0AAA9S5C5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5/entry#A0AAA9S4G3-1", "sequence": { "sequence": "MERALRSVARSPSGDVGRVAGTEDRASVPATYRKDFRVRCTSKRAVTEMLELCSSFVQKLGDALPEEIREPALRDAQWTFESAVQENVSINGQAWQEASDDCFMDSDIKVLEDQFDEIIVDLATKRKQYPRKILEYVIKIIKAQQEILKQYHPVVHLLDLKYDPDPVLTCIN", "length": 172, "header": "tr|A0AAA9S4G3-1|A0AAA9S5C5_BOVIN Computationally mapped isoform of NSL1 component of MIS12 kinetochore complex OS=Bos taurus OX=9913 GN=NSL1 PE=4 SV=1 CANONICAL=A0AAA9S5C5-1" }, "locus": { "chromosome": "16", "start_pos": 70804962, "end_pos": 70771053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093503.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093503.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080825.1" } ] } }, { "isoform_ac": "A0AAA9S5C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5/entry#A0AAA9S5C5-1", "sequence": { "sequence": "MAVTVHQPYAHRPHHSSHRNPWTRRRSHSRNASAAVGSISGRTCAPSSRETRPSALRIPAQSSSWKYGAGPQTFESAVQENVSINGQAWQEASDDCFMDSDIKVLEDQFDEIIVDLATKRKQYPRKILEYVIKIIKAQQEILKQYHPVVHLLDLKYDPDPAPRLENLRCRGGAVAKEISEAMKSLPALIEQGDGFSQVLKMQPIIQLQRVHQEVFSSCCRKPDVKPESFIAQIETTPAETSTRTATDLVLRRKRTKDCPQRKWYPLRRKRINLDT", "length": 275, "header": "tr|A0AAA9S5C5-1|A0AAA9S5C5_BOVIN Isoform 1 of NSL1 component of MIS12 kinetochore complex OS=Bos taurus OX=9913 GN=NSL1 PE=4 SV=1 CANONICAL=A0AAA9S5C5-1" }, "locus": { "chromosome": "16", "start_pos": 70805221, "end_pos": 70770854, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088214.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088214.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079063.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079063.1" } ] } }, { "isoform_ac": "A0AAA9TKG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5/entry#A0AAA9TKG6-1", "sequence": { "sequence": "MCLIPSWTLGNKKIKSRHIPCSQERTWPCKSFWTTENLSPATWETKFEEKKKRLQVASLTFESAVQENVSINGQAWQEASDDCFMDSDIKVLEDQFDEIIVDLATKRKQYPRKILEYVIKIIKAQQEILKQYHPVVHLLDLKYDPDPAPRLENLRCRGGAVAKEISEAMKSLPALIEQGDGFSQVLKMQPIIQLQRVHQEVFSSCCRKPDVKPESFIAQIETTPAETSTRTATDLVLRRKRTKDCPQRKWYPLRRKRINLDT", "length": 262, "header": "tr|A0AAA9TKG6-1|A0AAA9TKG6_BOVIN Computationally mapped isoform of NSL1 component of MIS12 kinetochore complex OS=Bos taurus OX=9913 GN=NSL1 PE=4 SV=1 CANONICAL=A0AAA9S5C5-1" }, "locus": { "chromosome": "16", "start_pos": 70805221, "end_pos": 70704521, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123594.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123594.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096759.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5" } ], "pmid": "" }, { "name": "MIS12/MIND type complex", "id": "GO:0000444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitotic sister chromatid segregation", "id": "GO:0000070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 31, "end_pos": 33 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4H3-1", "uniprot_ac": "A0AAA9S4H3", "uniprot_id": "A0AAA9S4H3_BOVIN", "mass": { "chemical_mass": 64062.0, "monoisotopic_mass": 64062.0 }, "refseq": { "ac": "XP_002686055", "name": "tetratricopeptide repeat protein 24 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686055" }, "gene_names": [ { "name": "TTC24", "type": "recommended", "evidence": [ { "id": "A0AAA9S4H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3" } ] }, { "name": "TTC24", "type": "synonym", "evidence": [ { "id": "XP_002686055", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686055" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 24", "type": "synonym", "evidence": [ { "id": "A0AAA9S4H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 24 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002686055", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686055" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3", "locus": { "chromosome": "3", "start_pos": 14247297, "end_pos": 14257049, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000401", "url": "https://www.ensembl.org/id/ENSBTAG00000000401" } ] } } ], "crossref": [ { "id": "A0AAA9S4H3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4H3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000401", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000401", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618203", "url": "https://www.ncbi.nlm.nih.gov/gene/618203", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013105", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013105", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618203", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618203", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BL14", "url": "https://www.orthodb.org/?gene=E1BL14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47050:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47050:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07719", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07719", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002686055", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686055", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL14", "url": "https://www.uniprot.org/uniprotkb/E1BL14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL14-1", "url": "https://www.uniprot.org/uniprotkb/E1BL14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSLNTEDTPQEPSLSSSSSKKKKKKRKWPQQEATIQALTRAGHRALLAGWNHEALTSFQRAFLLASKSPQTRDTPVLRACAFNLGAAYVETGDPARGLELLLRAQPQETAQGGCHGDQCFNVALAYHALGDLPQALAWYHKALCHYQPLGDQGQAQAKMGACYRALGQPGLAAHCLQEASRAYAQAGQPQAAALTLGAAAGCMLKSGQHGAGEVMQVLEESRRLAERSTERGLLGQLYNDLGLGYSQLQLFPLAVEAFLQALPLCREPGEEATVLRNLGMVHNALGNYQEARELHQKAADLHGSVGQRREQGWSFGSLAFAVSQLGDHKAARDNYLHALQAARDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALARSPKESDSVRERLVAKLTDAIRTHLARGGLLPTHTLTSAPERSLAPGGGGLVEGTPARVGRGAPGVQHRSSGGWEDELEEDHEGKEEESANVPTSRAPRLEDPRPKAHLSFGGQGPLRMENPGLLVPNVPRGNSSLHNLHPALEVRSVPRLLHGLSVGLGERENPAEWGNAWLKHTPHCPGAHQQRSFKQPREPPGRNPQKRSMESGFCIIM", "length": 593, "header": "tr|A0AAA9S4H3-1|A0AAA9S4H3_BOVIN Isoform 1 of Tetratricopeptide repeat domain 24 OS=Bos taurus OX=9913 GN=TTC24 PE=4 SV=1 CANONICAL=A0AAA9S4H3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3/entry#A0AAA9S4H3-1", "sequence": { "sequence": "MSSLNTEDTPQEPSLSSSSSKKKKKKRKWPQQEATIQALTRAGHRALLAGWNHEALTSFQRAFLLASKSPQTRDTPVLRACAFNLGAAYVETGDPARGLELLLRAQPQETAQGGCHGDQCFNVALAYHALGDLPQALAWYHKALCHYQPLGDQGQAQAKMGACYRALGQPGLAAHCLQEASRAYAQAGQPQAAALTLGAAAGCMLKSGQHGAGEVMQVLEESRRLAERSTERGLLGQLYNDLGLGYSQLQLFPLAVEAFLQALPLCREPGEEATVLRNLGMVHNALGNYQEARELHQKAADLHGSVGQRREQGWSFGSLAFAVSQLGDHKAARDNYLHALQAARDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALARSPKESDSVRERLVAKLTDAIRTHLARGGLLPTHTLTSAPERSLAPGGGGLVEGTPARVGRGAPGVQHRSSGGWEDELEEDHEGKEEESANVPTSRAPRLEDPRPKAHLSFGGQGPLRMENPGLLVPNVPRGNSSLHNLHPALEVRSVPRLLHGLSVGLGERENPAEWGNAWLKHTPHCPGAHQQRSFKQPREPPGRNPQKRSMESGFCIIM", "length": 593, "header": "tr|A0AAA9S4H3-1|A0AAA9S4H3_BOVIN Isoform 1 of Tetratricopeptide repeat domain 24 OS=Bos taurus OX=9913 GN=TTC24 PE=4 SV=1 CANONICAL=A0AAA9S4H3-1" }, "locus": { "chromosome": "3", "start_pos": 14255045, "end_pos": 14248301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087809.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087809.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080835.1" } ] } }, { "isoform_ac": "E1BL14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H3/entry#E1BL14-1", "sequence": { "sequence": "MSSLNTEDTPQEPSLSSSSSKKKKKKRKWPQQEATIQALTRAGHRALLAGWNHEALTSFQRAFLLASKSPQTRDTPVLRACAFNLGAAYVETGDPARGLELLLRAQPQETAQGGCHGDQCFNVALAYHALGDLPQALAWYHKALCHYQPLGDQGQAQAKMGACYRALGQPGLAAHCLQEASRAYAQAGQPQAAALTLGAAAGCMLKSGQHGAGEVMQVLEESRRLAERSTERGLLGQLYNDLGLGYSQLQLFPLAVEAFLQALPLCREPGEEATVLRNLGMVHNALGNYQEARELHQKAADLHGSVGQRREQGWSFGSLAFAVSQLGDHKAARDNYLHALQAARDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALARSPKESDSVRERLVAKLTDAIRTHLARGGLLPTHTLTSAPERSLAPGGGGLVEGTPARVGRGAPGVQHRSSGGWEDELEEDHEGKEEESANVPTSRAPRLEDPRPKAHLSFGGQGPLRMENPGLLVPNVPRGNRSFKQPREPPGRNPQKRSMESGFCIIM", "length": 541, "header": "tr|E1BL14-1|A0AAA9S4H3_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 24 OS=Bos taurus OX=9913 GN=TTC24 PE=4 SV=3 CANONICAL=A0AAA9S4H3-1" }, "locus": { "chromosome": "3", "start_pos": 14255045, "end_pos": 14248301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053417.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053417.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050395.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050395.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618203", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618203", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 514, "end_pos": 516 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4Z1-1", "uniprot_ac": "A0AAA9S4Z1", "uniprot_id": "A0AAA9S4Z1_BOVIN", "mass": { "chemical_mass": 22465.0, "monoisotopic_mass": 22465.0 }, "refseq": {}, "gene_names": [ { "name": "MS4A13", "type": "recommended", "evidence": [ { "id": "A0AAA9S4Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1" } ] } ], "protein_names": [ { "name": "Membrane spanning 4-domains A13", "type": "synonym", "evidence": [ { "id": "A0AAA9S4Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MS4A13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1", "locus": { "chromosome": "15", "start_pos": 83357744, "end_pos": 83332960, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030898", "url": "https://www.ensembl.org/id/ENSBTAG00000030898" } ] } } ], "crossref": [ { "id": "A0AAA9S4Z1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4Z1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030898", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505705", "url": "https://www.ncbi.nlm.nih.gov/gene/505705", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505705", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505705", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FNVLMWY", "url": "https://omabrowser.org/oma/group/FNVLMWY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLS7", "url": "https://www.orthodb.org/?gene=F1MLS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23320", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23320:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4K8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLS7", "url": "https://www.uniprot.org/uniprotkb/F1MLS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLS7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QRGCRWSLRCLRSLRAGWIPGPLIFPECRLGRVWGPGPEGAASRDPPPEPGQDTGGRTQSGQPLRSRVTCRRRDPRLSQGLGQGGRKDREQFIISGISIIRATWYPSQRQLTCAMLVNILCMILAIISMILTIVELSTFKSVSYRNYGQAKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 201, "header": "tr|A0AAA9S4Z1-1|A0AAA9S4Z1_BOVIN Isoform 1 of Membrane spanning 4-domains A13 OS=Bos taurus OX=9913 GN=MS4A13 PE=4 SV=1 CANONICAL=A0AAA9S4Z1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1/entry#A0AAA9S4K8-1", "sequence": { "sequence": "MAICTCCSKVSEADSLVIAAVQIMTGIFCIFMWYLLLILYMGQIKGVFGTYEPITYKTGCSLWGIFFIISGISIIRATWYPSQRQKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 136, "header": "tr|A0AAA9S4K8-1|A0AAA9S4Z1_BOVIN Computationally mapped isoform of Membrane spanning 4-domains A13 OS=Bos taurus OX=9913 GN=MS4A13 PE=4 SV=2 CANONICAL=A0AAA9S4Z1-1" }, "locus": { "chromosome": "15", "start_pos": 83357225, "end_pos": 83336629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090306.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090306.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080105.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080105.2" } ] } }, { "isoform_ac": "A0AAA9S4Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1/entry#A0AAA9S4Z1-1", "sequence": { "sequence": "QRGCRWSLRCLRSLRAGWIPGPLIFPECRLGRVWGPGPEGAASRDPPPEPGQDTGGRTQSGQPLRSRVTCRRRDPRLSQGLGQGGRKDREQFIISGISIIRATWYPSQRQLTCAMLVNILCMILAIISMILTIVELSTFKSVSYRNYGQAKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 201, "header": "tr|A0AAA9S4Z1-1|A0AAA9S4Z1_BOVIN Isoform 1 of Membrane spanning 4-domains A13 OS=Bos taurus OX=9913 GN=MS4A13 PE=4 SV=1 CANONICAL=A0AAA9S4Z1-1" }, "locus": { "chromosome": "15", "start_pos": 83357225, "end_pos": 83332962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099855.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099855.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078299.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078299.1" } ] } }, { "isoform_ac": "A0AAA9SGE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1/entry#A0AAA9SGE5-1", "sequence": { "sequence": "MTGIFCIFMWYLLLILYMGQIKGVFGTYEPITYKTGCSLWGIFKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 94, "header": "tr|A0AAA9SGE5-1|A0AAA9SGE5_BOVIN Computationally mapped isoform of Membrane spanning 4-domains A13 OS=Bos taurus OX=9913 GN=MS4A13 PE=4 SV=1 CANONICAL=A0AAA9S4Z1-1" }, "locus": { "chromosome": "15", "start_pos": 83357225, "end_pos": 83337850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092258.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092258.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082753.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082753.1" } ] } }, { "isoform_ac": "F1MLS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1/entry#F1MLS7-1", "sequence": { "sequence": "MAICTCCSKVSEADSLVIAAVQIMTGIFCIFMWYLLLILYMGQIKGVFGTYEPITYKTGCSLWGIFFIISGISIIRATWYPSQRQLTCAMLVNILCMILAIISMILTIVELSTFKSVSYRNYGQAKLGRQISRVLLSFYPLEVSMALTYSIFGCVGLCRKKEDARTADTEEVEDAF", "length": 176, "header": "tr|F1MLS7-1|A0AAA9S4Z1_BOVIN Computationally mapped isoform of Membrane spanning 4-domains A13 OS=Bos taurus OX=9913 GN=MS4A13 PE=4 SV=2 CANONICAL=A0AAA9S4Z1-1" }, "locus": { "chromosome": "15", "start_pos": 83357225, "end_pos": 83336629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043721.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043721.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041271.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041271.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505705", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505705", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GSI7-1", "protein_name": "Membrane-spanning 4-domains subfamily A member 13", "gene_name": "Ms4a13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGCGNSKISSENVIVLGVIQIIIGIYHVLMWYFLLLLYMGQIKGVFGTYEPLTYKMGTALWGFAFIISGAFTVKSAKRPSRYLLECALSLNILCMIVTIIAASLTIVELANFHSVSYKNYGQAKLGREVSRILLISYPLEFAMALTYAIYSCSHLGRRQEESLETVSDAIDGKF", "length": 174 }, "evidence": [ { "id": "A0AAA9S4Z1", "url": "https://omabrowser.org/oma/group/A0AAA9S4Z1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZVW8-1", "protein_name": "Membrane spanning 4-domains A13", "gene_name": "Ms4a13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGCRNSKISSANTAVLGVIQIMIGIYHVLMWYFLLLLYMGQIKGVFGTYEPLTYKMGTSLWGLTFVLSGAFTIKAAKYRSRFMLLCTMSLNILCIIVTIIAASLTIVELSHFRSVSYRNYGQAKLGREVSRILLCSYPLEFVVALTYSISGCAYLMETQDENSESVTEVVEDNF", "length": 174 }, "evidence": [ { "id": "A0AAA9S4Z1", "url": "https://omabrowser.org/oma/group/A0AAA9S4Z1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J8X5-1", "protein_name": "Membrane-spanning 4-domains subfamily A member 13", "gene_name": "MS4A13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIGIFHIFMWYFLLVLYMGQIKGAFGTYEPVTYKTGCTLWGIFFIIAGVFLIRVTKYPTRSGIISTLIINIICIITTITAVTLTIIELSHFNSVSYRNYGQAKLGREVSRILLFFYGLEFSIALTHSIYSCSNLFRRQNDLTSVTEEAESTP", "length": 152 }, "evidence": [ { "id": "A0AAA9S4Z1", "url": "https://omabrowser.org/oma/group/A0AAA9S4Z1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4M1-1", "uniprot_ac": "A0AAA9S4M1", "uniprot_id": "A0AAA9S4M1_BOVIN", "mass": { "chemical_mass": 14294.0, "monoisotopic_mass": 14294.0 }, "refseq": { "ac": "XP_024839749", "name": "transmembrane protein 170B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839749" }, "gene_names": [ { "name": "TMEM170B", "type": "recommended", "evidence": [ { "id": "A0AAA9S4M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1" } ] }, { "name": "TMEM170B", "type": "synonym", "evidence": [ { "id": "XP_024839749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839749" } ] } ], "protein_names": [ { "name": "Transmembrane protein 170B", "type": "synonym", "evidence": [ { "id": "A0AAA9S4M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 170B", "type": "synonym", "evidence": [ { "id": "XP_024839749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839749" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM170B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1", "locus": { "chromosome": "23", "start_pos": 44801115, "end_pos": 44835870, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061554", "url": "https://www.ensembl.org/id/ENSBTAG00000061554" } ] } } ], "crossref": [ { "id": "A0AAA9S4M1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4M1", "database": "AlphaFoldDB", "categories": [] }, { "id": "101906104", "url": "https://www.ncbi.nlm.nih.gov/gene/101906104", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101906104", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906104", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DHMINLS", "url": "https://omabrowser.org/oma/group/DHMINLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22779", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22779", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22779:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22779:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839749", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839749", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAEGGDASMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISVIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL", "length": 132, "header": "tr|A0AAA9S4M1-1|A0AAA9S4M1_BOVIN Isoform 1 of Transmembrane protein 170B OS=Bos taurus OX=9913 GN=TMEM170B PE=3 SV=1 CANONICAL=A0AAA9S4M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1/entry#A0AAA9S4M1-1", "sequence": { "sequence": "MKAEGGDASMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISVIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL", "length": 132, "header": "tr|A0AAA9S4M1-1|A0AAA9S4M1_BOVIN Isoform 1 of Transmembrane protein 170B OS=Bos taurus OX=9913 GN=TMEM170B PE=3 SV=1 CANONICAL=A0AAA9S4M1-1" }, "locus": { "chromosome": "23", "start_pos": 44835671, "end_pos": 44802119, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117737.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117737.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078765.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101906104", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906104", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZZD1-1", "protein_name": "Transmembrane protein 170B", "gene_name": "TMEM170B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKAEGGDHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISVIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL", "length": 132 }, "evidence": [ { "id": "A0AAA9S4M1", "url": "https://omabrowser.org/oma/group/A0AAA9S4M1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y5X1-1", "protein_name": "Transmembrane protein 170B", "gene_name": "TMEM170B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKVEAGDNSMINLSVQQVLSLWAHGTVLRNLTEMWYWVFLWALFSSLFVHGAVGVLMFVMLQRHRQGRLISVIVVSIGFLGSVTGAMITSAAVAGIYRVAGKNMAPLEALVFGVGQTVLTLIISFSRILATL", "length": 132 }, "evidence": [ { "id": "A0AAA9S4M1", "url": "https://omabrowser.org/oma/group/A0AAA9S4M1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P86050-1", "protein_name": "Transmembrane protein 170B", "gene_name": "Tmem170b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRAEGADHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISIIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL", "length": 132 }, "evidence": [ { "id": "A0AAA9S4M1", "url": "https://omabrowser.org/oma/group/A0AAA9S4M1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T4T1-1", "protein_name": "Transmembrane protein 170B", "gene_name": "TMEM170B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKAEGGDHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISVIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL", "length": 132 }, "evidence": [ { "id": "A0AAA9S4M1", "url": "https://omabrowser.org/oma/group/A0AAA9S4M1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TQ79-1", "protein_name": "Transmembrane protein 170B", "gene_name": "Tmem170b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRAEGADHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVLSIIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL", "length": 132 }, "evidence": [ { "id": "A0AAA9S4M1", "url": "https://omabrowser.org/oma/group/A0AAA9S4M1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4R5-1", "uniprot_ac": "A0AAA9S4R5", "uniprot_id": "A0AAA9S4R5_BOVIN", "mass": { "chemical_mass": 32544.0, "monoisotopic_mass": 32544.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Olfactory receptor family 5 subfamily AP member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5", "locus": {} } ], "crossref": [ { "id": "A0AAA9S4R5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4R5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4R5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "IYMKEMQTRNQTEVTAFILLGLSDNSELQVILFGLFLLIYMATVVGNLGVIVLIKMDPCLHTPMYFFLSSLSFVDASYSSSVTPKMLVNLVAESKAISFNGRAAQFYFFGSFLGTECLLLATMAYDLYIAIWNPLLYPVLMSGRICFLLAATSFLADFGNVAIHTGMTFKLSFCGSDKTNHFYCDTPALLKLSCSDTRINGIVIMAFSSVTVTGCVMIVLTSYLCILVAILRMPSLEGRHRAFSTCTSYSMEQDKIVSVFYTVVITMLNPLIYSLKNKDVKGALKKILQQQIL", "length": 293, "header": "tr|A0AAA9S4R5-1|A0AAA9S4R5_BOVIN Isoform 1 of Olfactory receptor family 5 subfamily AP member 2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S4R5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4R5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5/entry#A0AAA9S4R5-1", "sequence": { "sequence": "IYMKEMQTRNQTEVTAFILLGLSDNSELQVILFGLFLLIYMATVVGNLGVIVLIKMDPCLHTPMYFFLSSLSFVDASYSSSVTPKMLVNLVAESKAISFNGRAAQFYFFGSFLGTECLLLATMAYDLYIAIWNPLLYPVLMSGRICFLLAATSFLADFGNVAIHTGMTFKLSFCGSDKTNHFYCDTPALLKLSCSDTRINGIVIMAFSSVTVTGCVMIVLTSYLCILVAILRMPSLEGRHRAFSTCTSYSMEQDKIVSVFYTVVITMLNPLIYSLKNKDVKGALKKILQQQIL", "length": 293, "header": "tr|A0AAA9S4R5-1|A0AAA9S4R5_BOVIN Isoform 1 of Olfactory receptor family 5 subfamily AP member 2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S4R5-1" }, "locus": { "chromosome": "15", "start_pos": 79848897, "end_pos": 79847776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066032.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066032.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078823.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078823.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4R5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 268, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4V6-1", "uniprot_ac": "A0AAA9S4V6", "uniprot_id": "A0AAA9S4V6_BOVIN", "mass": { "chemical_mass": 41610.0, "monoisotopic_mass": 41610.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF391", "type": "recommended", "evidence": [ { "id": "A0AAA9S4V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" } ] } ], "protein_names": [ { "name": "Zinc finger protein 391", "type": "synonym", "evidence": [ { "id": "A0AAA9S4V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF391", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6", "locus": { "chromosome": "23", "start_pos": 31189065, "end_pos": 31217328, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009152", "url": "https://www.ensembl.org/id/ENSBTAG00000009152" } ] } } ], "crossref": [ { "id": "A0AAA9S4V6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4V6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESLQGNTAQHPMDEKACKSEGQLSRQTKCPVQKKSSFEKTAIRKVSVSLKEIFAKEKGPEYSKFNLSSNFNTRQRIPKGARSPKSRKNSKDNSDLIKHQKLFLQRKPCKCNECGKAFNYESDLIVHRRIHGGEKPFECNECGKTFSRSTHLIEHQRTHTGEKPYECPECGKAFSRSTHLSLHQRIHTGEKPYECSECGKAFSRSTNLSQHQRTHTQEKPYKCNECGKAFSDRSTIIQHQRIHTGENPYECSECGKAYSWISSLIEHQRTHSGENPYECNDCGKVFSRSSSLAEHQRIHTGEKPHECRVCGKGFSRSSSLIIHQRTHTREKPFKCNSCEKAFSQSSTLIRHQQLHTKDLSFQS", "length": 363, "header": "tr|A0AAA9S4V6-1|A0AAA9S4V6_BOVIN Isoform 1 of Zinc finger protein 391 OS=Bos taurus OX=9913 GN=ZNF391 PE=3 SV=1 CANONICAL=A0AAA9S4V6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6/entry#A0AAA9S4V6-1", "sequence": { "sequence": "MESLQGNTAQHPMDEKACKSEGQLSRQTKCPVQKKSSFEKTAIRKVSVSLKEIFAKEKGPEYSKFNLSSNFNTRQRIPKGARSPKSRKNSKDNSDLIKHQKLFLQRKPCKCNECGKAFNYESDLIVHRRIHGGEKPFECNECGKTFSRSTHLIEHQRTHTGEKPYECPECGKAFSRSTHLSLHQRIHTGEKPYECSECGKAFSRSTNLSQHQRTHTQEKPYKCNECGKAFSDRSTIIQHQRIHTGENPYECSECGKAYSWISSLIEHQRTHSGENPYECNDCGKVFSRSSSLAEHQRIHTGEKPHECRVCGKGFSRSSSLIIHQRTHTREKPFKCNSCEKAFSQSSTLIRHQQLHTKDLSFQS", "length": 363, "header": "tr|A0AAA9S4V6-1|A0AAA9S4V6_BOVIN Isoform 1 of Zinc finger protein 391 OS=Bos taurus OX=9913 GN=ZNF391 PE=3 SV=1 CANONICAL=A0AAA9S4V6-1" }, "locus": { "chromosome": "23", "start_pos": 31200995, "end_pos": 31197851, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120329.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120329.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078263.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078263.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4V6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 109, "end_pos": 136, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4W8-1", "uniprot_ac": "A0AAA9S4W8", "uniprot_id": "A0AAA9S4W8_BOVIN", "mass": { "chemical_mass": 11521.0, "monoisotopic_mass": 11521.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S4W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8", "locus": {} } ], "crossref": [ { "id": "A0AAA9S4W8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4W8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4W8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQKVTQDQPQVLGQEKEAVTLDCKYDTSDSRYSLVWYKQPSSGGMILLIRQDSSNQQNATEGRYSLNFQKARQSVTLVISASQLEDSAVYFCALREPTVRRV", "length": 102, "header": "tr|A0AAA9S4W8-1|A0AAA9S4W8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S4W8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4W8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8/entry#A0AAA9S4W8-1", "sequence": { "sequence": "AQKVTQDQPQVLGQEKEAVTLDCKYDTSDSRYSLVWYKQPSSGGMILLIRQDSSNQQNATEGRYSLNFQKARQSVTLVISASQLEDSAVYFCALREPTVRRV", "length": 102, "header": "tr|A0AAA9S4W8-1|A0AAA9S4W8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S4W8-1" }, "locus": { "chromosome": "10", "start_pos": 22786086, "end_pos": 22785781, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077184.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077184.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 102, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4X9-1", "uniprot_ac": "A0AAA9S4X9", "uniprot_id": "A0AAA9S4X9_BOVIN", "mass": { "chemical_mass": 11305.0, "monoisotopic_mass": 11305.0 }, "refseq": { "ac": "XP_015329744", "name": "uncharacterized protein C20orf202 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329744" }, "gene_names": [ { "name": "C13H20orf202", "type": "recommended", "evidence": [ { "id": "A0AAA9S4X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9" } ] }, { "name": "C13H20orf202", "type": "synonym", "evidence": [ { "id": "XP_015329744", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329744" } ] } ], "protein_names": [ { "name": "Chromosome 20 open reading frame 202", "type": "synonym", "evidence": [ { "id": "A0AAA9S4X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C20orf202 homolog", "type": "synonym", "evidence": [ { "id": "XP_015329744", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329744" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C13H20orf202", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9", "locus": {} } ], "crossref": [ { "id": "A0AAA9S4X9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4X9", "database": "AlphaFoldDB", "categories": [] }, { "id": "100296025", "url": "https://www.ncbi.nlm.nih.gov/gene/100296025", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296025", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296025", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RAESAHW", "url": "https://omabrowser.org/oma/group/RAESAHW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR32289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32289:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32289:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_015329744", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329744", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTKEEPTSSLGQTLEWLRKELTEMQDQDQRLLLTLRHLHSVLEELRTESVQWEDARSSGGTSPIRARAGSEGRGRQPFPSRRLAHLLQGVDSRRSSLP", "length": 99, "header": "tr|A0AAA9S4X9-1|A0AAA9S4X9_BOVIN Isoform 1 of Chromosome 20 open reading frame 202 OS=Bos taurus OX=9913 GN=C13H20orf202 PE=4 SV=1 CANONICAL=A0AAA9S4X9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X9/entry#A0AAA9S4X9-1", "sequence": { "sequence": "MKTKEEPTSSLGQTLEWLRKELTEMQDQDQRLLLTLRHLHSVLEELRTESVQWEDARSSGGTSPIRARAGSEGRGRQPFPSRRLAHLLQGVDSRRSSLP", "length": 99, "header": "tr|A0AAA9S4X9-1|A0AAA9S4X9_BOVIN Isoform 1 of Chromosome 20 open reading frame 202 OS=Bos taurus OX=9913 GN=C13H20orf202 PE=4 SV=1 CANONICAL=A0AAA9S4X9-1" }, "locus": { "chromosome": "13", "start_pos": 59938562, "end_pos": 59936281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119427.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119427.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078901.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296025", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296025", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A571BEE7-1", "protein_name": "Transmembrane 74B, opposite strand", "gene_name": "Tmem74bos", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMPGEPAASLGQTLEWLREELAEMQIQDQKLLLTLRHLHSLLEELRAESTHWQDTRPSRNTSPFRARLGSEGRACQPVPRQLTELLRGEKSRRSSLP", "length": 98 }, "evidence": [ { "id": "A0AAA9S4X9", "url": "https://omabrowser.org/oma/group/A0AAA9S4X9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A9J7KAQ2-1", "protein_name": "Uncharacterized protein C20orf202 homolog", "gene_name": "CUNH20orf202", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKPEEPAVTLGQTLEWLRKELAEMQIQDQQLLLSLRHLQSLLEELRAESTHWEDTRPSRNTSPFRARLGSEGRSCQPVSRELAQLLQREESRRSSLP", "length": 98 }, "evidence": [ { "id": "A0AAA9S4X9", "url": "https://omabrowser.org/oma/group/A0AAA9S4X9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1L168-1", "protein_name": "Uncharacterized protein C20orf202", "gene_name": "C20orf202", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKIAEEPSPSLGQTLEWLRKELSEMQIQDQSLLLTLRHLHSVLEELRADSAHWEDARSSGGTSPIRARAGSEGRGCQPVCSRGLAQLLRGEDSRRSSLP", "length": 99 }, "evidence": [ { "id": "A0AAA9S4X9", "url": "https://omabrowser.org/oma/group/A0AAA9S4X9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1S873-1", "protein_name": "Chromosome 17 C20orf202 homolog", "gene_name": "C17H20orf202", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFKSQVPRAHHQVSVKVSPKDTEMKTAEEPTSSLGQILEWLRKELAEMQVQDQRLLLTLRHLHSILEELRAESAHWEDARSSGGTSPIRARADSEGRGRQPFSSRGLAHLLQGVDSRRSSLP", "length": 122 }, "evidence": [ { "id": "A0AAA9S4X9", "url": "https://omabrowser.org/oma/group/A0AAA9S4X9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4Y0-1", "uniprot_ac": "A0AAA9S4Y0", "uniprot_id": "A0AAA9S4Y0_BOVIN", "mass": { "chemical_mass": 206183.0, "monoisotopic_mass": 206183.0 }, "refseq": { "ac": "XP_024837770", "name": "tight junction protein ZO-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837770" }, "gene_names": [ { "name": "TJP1", "type": "recommended", "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" } ] }, { "name": "TJP1", "type": "synonym", "evidence": [ { "id": "XP_024837770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837770" } ] } ], "protein_names": [ { "name": "Zona occludens protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0/entry#names_and_taxonomy" } ] }, { "name": "Zonula occludens protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0/entry#names_and_taxonomy" } ] }, { "name": "tight junction protein ZO-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024837770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837770" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TJP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0", "locus": { "chromosome": "21", "start_pos": 28399101, "end_pos": 28658085, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015398", "url": "https://www.ensembl.org/id/ENSBTAG00000015398" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015398", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015398", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06727", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06727", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06728", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06728", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06729", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06729", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12026", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12026", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "407102", "url": "https://www.ncbi.nlm.nih.gov/gene/407102", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407102", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407102", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13865", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13865", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13865:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13865:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024837770", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837770", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SED4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SED4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2D3", "url": "https://www.uniprot.org/uniprotkb/F1N2D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2D3-1", "url": "https://www.uniprot.org/uniprotkb/F1N2D3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRLEGLCLRRRRRRGPGRERSGDKMKYQKYLTVLQMAIGVTPSNRGSLLPLKRRLWVTPSSENPSGATSSVSQGKPSLRRIKGRLHRSKSLDSIDFCELTNTTMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVNRPDPEPVSENEEDSYDEEAHDPRSGRGALANRRSEKSWGRDRSASRERSLSPRSDRRSVASSQPARPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSADASERDDISEIQSLASDHSGRSHDRPPRHSRSRSPDQRSEPSDHSRHSPQQPSSGSLRSREEERISKPGAVSTPVKHADDHTPKTVEEVVVERNEKQAPNLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHPDHQAYPPYSPQAQPQPGHRIDSPGFKTASQQKAEASSPGPYLSPETNPAPSASAVNPHVDLTNVRLEEPSPAPPSSDSPHADSLRAPGTEAAHVQLKGPEPSLSSHVGPAKVYRKDPYPEEMMRQNHVLKQPAVVHPGQRPDKEQGLSYEPQPPYTERQAGRELERPAYRYDASSYPEQFARNYDHRLRYDDRLLTYEEQWPYYDDKQPYQPRPLDGQPPAEPTERGYFPRFEEPVPLSYEGRAHYDPLPRTSTLRHEEPPAPAPGYDVHGRYRPDVQPYSTAGPKVPPEPKQYLDQYPRSYEPAPAQGFPSRAGPGHYEPLHSTTLAPPLGPSSQHKPEVPPTGTKPLPPPPAPAEEEEDPAMKPQSVLTRVKMFENKRSASMENRKDESHSTSFKPPEVTSKPAGAPVPGPKAPAPSQLGEHDRAAHRIPEPQRPHMKPPEDIVRANHYDPEEDEEYYRKQLSYFDRRSFEAKPPTHIPTSHLSEPTRPAHPQSQPQFAGYSSKGKAAEAEAVDRSFGEKRYDPLQATPPPPPLPVQYSQGAQPSPNTALGLHAHTKGAHGEGNAMSLDFQNSLVSKPDPPPSQNKPAAYRPAPREDAVQSGFYPQKSFPEKAPANGVEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPNETAHKPDLSSKAPASPKTLLKSAQPPEFDSGVETLSVHTDNKLKYQVNSVSMGPRAVPVSPSAVEEDEDEDGHTVVATARGVFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1855, "header": "tr|A0AAA9S4Y0-1|A0AAA9S4Y0_BOVIN Isoform 1 of Zona occludens protein 1 OS=Bos taurus OX=9913 GN=TJP1 PE=3 SV=1 CANONICAL=A0AAA9S4Y0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0/entry#A0AAA9S4Y0-1", "sequence": { "sequence": "MRRLEGLCLRRRRRRGPGRERSGDKMKYQKYLTVLQMAIGVTPSNRGSLLPLKRRLWVTPSSENPSGATSSVSQGKPSLRRIKGRLHRSKSLDSIDFCELTNTTMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVNRPDPEPVSENEEDSYDEEAHDPRSGRGALANRRSEKSWGRDRSASRERSLSPRSDRRSVASSQPARPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSADASERDDISEIQSLASDHSGRSHDRPPRHSRSRSPDQRSEPSDHSRHSPQQPSSGSLRSREEERISKPGAVSTPVKHADDHTPKTVEEVVVERNEKQAPNLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHPDHQAYPPYSPQAQPQPGHRIDSPGFKTASQQKAEASSPGPYLSPETNPAPSASAVNPHVDLTNVRLEEPSPAPPSSDSPHADSLRAPGTEAAHVQLKGPEPSLSSHVGPAKVYRKDPYPEEMMRQNHVLKQPAVVHPGQRPDKEQGLSYEPQPPYTERQAGRELERPAYRYDASSYPEQFARNYDHRLRYDDRLLTYEEQWPYYDDKQPYQPRPLDGQPPAEPTERGYFPRFEEPVPLSYEGRAHYDPLPRTSTLRHEEPPAPAPGYDVHGRYRPDVQPYSTAGPKVPPEPKQYLDQYPRSYEPAPAQGFPSRAGPGHYEPLHSTTLAPPLGPSSQHKPEVPPTGTKPLPPPPAPAEEEEDPAMKPQSVLTRVKMFENKRSASMENRKDESHSTSFKPPEVTSKPAGAPVPGPKAPAPSQLGEHDRAAHRIPEPQRPHMKPPEDIVRANHYDPEEDEEYYRKQLSYFDRRSFEAKPPTHIPTSHLSEPTRPAHPQSQPQFAGYSSKGKAAEAEAVDRSFGEKRYDPLQATPPPPPLPVQYSQGAQPSPNTALGLHAHTKGAHGEGNAMSLDFQNSLVSKPDPPPSQNKPAAYRPAPREDAVQSGFYPQKSFPEKAPANGVEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPNETAHKPDLSSKAPASPKTLLKSAQPPEFDSGVETLSVHTDNKLKYQVNSVSMGPRAVPVSPSAVEEDEDEDGHTVVATARGVFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1855, "header": "tr|A0AAA9S4Y0-1|A0AAA9S4Y0_BOVIN Isoform 1 of Zona occludens protein 1 OS=Bos taurus OX=9913 GN=TJP1 PE=3 SV=1 CANONICAL=A0AAA9S4Y0-1" }, "locus": { "chromosome": "21", "start_pos": 28657991, "end_pos": 28400105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115409.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115409.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080992.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080992.1" } ] } }, { "isoform_ac": "A0AAA9SED4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0/entry#A0AAA9SED4-1", "sequence": { "sequence": "MRRLEGLCLRRRRRRGPGRERSGDKMKYQKYLTVLQMAIGVTPSNRGSLLPLKRRLWVTPSSENPSGATSSVSQGKPSLRRIKGRLHRSKSLDSIDFCELTNTTMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVNRPDPEPVSENEEDSYDEEAHDPRSGRGALANRRSEKSWGRDRSASRERSLSPRSDRRSVASSQPARPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSADASERDDISEIQSLASDHSGRSHDRPPRHSRSRSPDQRSEPSDHSRHSPQQPSSGSLRSREEERISKPGAVSTPVKHADDHTPKTVEEVVVERNEKQAPNLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHPDHQAYPPYSPQAQPQPGHRIDSPGFKTASQQVYRKDPYPEEMMRQNHVLKQPAVVHPGQRPDKEQGLSYEPQPPYTERQAGRELERPAYRYDASSYPEQFARNYDHRLRYDDRLLTYEEQWPYYDDKQPYQPRPLDGQPPAEPTERGYFPRFEEPVPLSYEGRAHYDPLPRTSTLRHEEPPAPAPGYDVHGRYRPDVQPYSTAGPKVPPEPKQYLDQYPRSYEPAPAQGFPSRAGPGHYEPLHSTTLAPPLGPSSQHKPEVPPTGTKPLPPPPAPAEEEEDPAMKPQSVLTRVKMFENKRSASMENRKDESHSTSFKPPEVTSKPAGAPVPGPKAPAPSQLGEHDRAAHRIPEPQRPHMKPPEDIVRANHYDPEEDEEYYRKQLSYFDRRSFEAKPPTHIPTSHLSEPTRPAHPQSQPQFAGYSSKGKAAEAEAVDRSFGEKRYDPLQATPPPPPLPVQYSQGAQPSPNTALGLHAHTKGAHGEGNAMSLDFQNSLVSKPDPPPSQNKPAAYRPAPREDAVQSGFYPQKSFPEKAPANGVEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPNETAHKPDLSSKAPASPKTLLKSAQPPEFDSGVETLSVHTDNKLKYQVNSVSMGPRAVPVSPSAVEEDEDEDGHTVVATARGVFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1775, "header": "tr|A0AAA9SED4-1|A0AAA9SED4_BOVIN Computationally mapped isoform of Zona occludens protein 1 OS=Bos taurus OX=9913 GN=TJP1 PE=3 SV=1 CANONICAL=A0AAA9S4Y0-1" }, "locus": { "chromosome": "21", "start_pos": 28657991, "end_pos": 28400105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113902.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113902.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083758.1" } ] } }, { "isoform_ac": "F1N2D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0/entry#F1N2D3-1", "sequence": { "sequence": "MSARAAAAKNTTMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVNRPDPEPVSENEEDSYDEEAHDPRSGRGALANRRSEKSWGRDRSASRERSLSPRSDRRSVASSQPARPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSADASERDDISEIQSLASDHSGRSHDRPPRHSRSRSPDQRSEPSDHSRHSPQQPSSGSLRSREEERISKPGAVSTPVKHADDHTPKTVEEVVVERNEKQAPNLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHPDHQAYPPYSPQAQPQPGHRIDSPGFKTASQQKAEASSPGPYLSPETNPAPSASAVNPHVDLTNVRLEEPSPAPPSSDSPHADSLRAPGTEAAHVQLKGPEPSLSSHVGPAKVYRKDPYPEEMMRQNHVLKQPAVVHPGQRPDKEQGLSYEPQPPYTERQAGRELERPAYRYDASSYPEQFARNYDHRLRYDDRLLTYEEQWPYYDDKQPYQPRPLDGQPPAEPTERGYFPRFEEPVPLSYEGRAHYDPLPRTSTLRHEEPPAPAPGYDVHGRYRPDVQPYSTAGPKVPPEPKQYLDQYPRSYEPAPAQGFPSRAGPGHYEPLHSTTLAPPLGPSSQHKPEVPPTGTKPLPPPPAPAEEEEDPAMKPQSVLTRVKMFENKRSASMENRKDESHSTSFKPPEVTSKPAGAPVPGPKAPAPSQLGEHDRAAHRIPEPQRPHMKPPEDIVRANHYDPEEDEEYYRKQLSYFDRRSFEAKPPTHIPTSHLSEPTRPAHPQSQPQFAGYSSKGKAAEAEAVDRSFGEKRYDPLQATPPPPPLPVQYSQGAQPSPNTALGLHAHTKGAHGEGNAMSLDFQNSLVSKPDPPPSQNKPAAYRPAPREDAVQSGFYPQKSFPEKAPANGVEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPNETAHKPDLSSKAPASPKTLLKSAQPPEFDSGVETLSVHTDNKLKYQVNSVSMGPRAVPVSPSAVEEDEDEDGHTVVATARGVFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF", "length": 1763, "header": "tr|F1N2D3-1|A0AAA9S4Y0_BOVIN Computationally mapped isoform of Zona occludens protein 1 OS=Bos taurus OX=9913 GN=TJP1 PE=3 SV=4 CANONICAL=A0AAA9S4Y0-1" }, "locus": { "chromosome": "21", "start_pos": 28510189, "end_pos": 28400105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038824.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038824.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038633.6", "url": "https://www.ensembl.org/id/ENSBTAP00000038633.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1610, "start_aa": "Thr", "end_pos": 1610, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1610", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 42, "start_aa": "Thr", "end_pos": 42, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr42", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:407102", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407102", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" } ], "pmid": "" }, { "name": "gap junction", "id": "GO:0005921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005921", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1644, "end_pos": 1646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 782, "end_pos": 883, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 202, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 608, "end_pos": 676, "start_aa": "Gly", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S4Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y0" }, { "id": "PS51145", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZU5", "eco_id": "ECO_0000259", "start_pos": 1721, "end_pos": 1855, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 42, 1610 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 1644, "end_pos": 1646 }, { "start_pos": 325, "end_pos": 327 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 502, "end_pos": 504 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4Y4-1", "uniprot_ac": "A0AAA9S4Y4", "uniprot_id": "A0AAA9S4Y4_BOVIN", "mass": { "chemical_mass": 13396.0, "monoisotopic_mass": 13396.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ubiquitin-fold modifier 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S4Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4#function" }, { "database": "UniProtKB", "id": "ARBA00045800", "url": "https://www.uniprot.org/uniprotkb/ARBA00045800#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4", "locus": {} } ], "crossref": [ { "id": "cd01766", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01766", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15825", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15825", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15825:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15825:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03671", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03671", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIILEIVLDIVNICCLEHKTPFQSKYWYCYCKIGIRHLKSYENTSN", "length": 120, "header": "tr|A0AAA9S4Y4-1|A0AAA9S4Y4_BOVIN Isoform 1 of Ubiquitin-fold modifier 1 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S4Y4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4/entry#A0AAA9S4Y4-1", "sequence": { "sequence": "MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIILEIVLDIVNICCLEHKTPFQSKYWYCYCKIGIRHLKSYENTSN", "length": 120, "header": "tr|A0AAA9S4Y4-1|A0AAA9S4Y4_BOVIN Isoform 1 of Ubiquitin-fold modifier 1 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S4Y4-1" }, "locus": { "chromosome": "6", "start_pos": 69404524, "end_pos": 69404165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126298.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126298.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098993.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098993.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ufmylation", "id": "GO:0071569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071569", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Y4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4Z0-1", "uniprot_ac": "A0AAA9S4Z0", "uniprot_id": "A0AAA9S4Z0_BOVIN", "mass": { "chemical_mass": 32216.0, "monoisotopic_mass": 32216.0 }, "refseq": { "ac": "XP_005214584", "name": "RNA-binding protein Raly isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214584" }, "gene_names": [ { "name": "RALY", "type": "recommended", "evidence": [ { "id": "A0AAA9S4Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ] }, { "name": "RALY", "type": "synonym", "evidence": [ { "id": "XP_005214584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214584" } ] } ], "protein_names": [ { "name": "RALY heteroous nuclear ribonucleoprotein", "type": "synonym", "evidence": [ { "id": "A0AAA9S4Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein Raly isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214584" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RALY", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0", "locus": { "chromosome": "13", "start_pos": 63464846, "end_pos": 63374875, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016524", "url": "https://www.ensembl.org/id/ENSBTAG00000016524" } ] } } ], "crossref": [ { "id": "A0AAA9S4Z0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4Z0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12604", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12604", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504640", "url": "https://www.ncbi.nlm.nih.gov/gene/504640", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13968:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13968:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214584", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLKIQTSNVTNKNDPKSINSRVFIGNLNTAVVKKSDVETIFSKYGRVAGCSVHKGYAFVQYANERHARAAVVGENGRVLAGQTLDINMAGEPKPNRPKGLKRAASAIYSGYSFDYDYYRDDFYDRLFDYRGRLSPVPVPRAVPVKRPRVTVPLVRRVKTTIPVKLFARSTAITTGTAKIKLKSSELQTIKTELTQIKSNIDALLGRLEQIAEEQKANPDGKKKGESSSGSGSGGGSGSSGTGGSSRPPAPPEDTASEAGTPQGEAQARDDGDEEGLLTHSEEELEHSQDTDVEDGALQ", "length": 299, "header": "tr|A0AAA9S4Z0-1|A0AAA9S4Z0_BOVIN Isoform 1 of RALY heteroous nuclear ribonucleoprotein OS=Bos taurus OX=9913 GN=RALY PE=3 SV=1 CANONICAL=A0AAA9S4Z0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0/entry#A0AAA9S4Z0-1", "sequence": { "sequence": "MSLKIQTSNVTNKNDPKSINSRVFIGNLNTAVVKKSDVETIFSKYGRVAGCSVHKGYAFVQYANERHARAAVVGENGRVLAGQTLDINMAGEPKPNRPKGLKRAASAIYSGYSFDYDYYRDDFYDRLFDYRGRLSPVPVPRAVPVKRPRVTVPLVRRVKTTIPVKLFARSTAITTGTAKIKLKSSELQTIKTELTQIKSNIDALLGRLEQIAEEQKANPDGKKKGESSSGSGSGGGSGSSGTGGSSRPPAPPEDTASEAGTPQGEAQARDDGDEEGLLTHSEEELEHSQDTDVEDGALQ", "length": 299, "header": "tr|A0AAA9S4Z0-1|A0AAA9S4Z0_BOVIN Isoform 1 of RALY heteroous nuclear ribonucleoprotein OS=Bos taurus OX=9913 GN=RALY PE=3 SV=1 CANONICAL=A0AAA9S4Z0-1" }, "locus": { "chromosome": "13", "start_pos": 63463276, "end_pos": 63456822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123606.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123606.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081003.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081003.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S4Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z0" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 92, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S525-1", "uniprot_ac": "A0AAA9S525", "uniprot_id": "A0AAA9S525_BOVIN", "mass": { "chemical_mass": 59106.0, "monoisotopic_mass": 59106.0 }, "refseq": { "ac": "XP_002696317", "name": "E3 ubiquitin-protein ligase NEURL1B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696317" }, "gene_names": [ { "name": "NEURL1B", "type": "recommended", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ] }, { "name": "NEURL1B", "type": "synonym", "evidence": [ { "id": "XP_002696317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696317" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase NEURL1B", "type": "recommended", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase NEURL1B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002696317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696317" } ] }, { "name": "Neuralized-2", "type": "synonym", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#names_and_taxonomy" } ] }, { "name": "Neuralized-like protein 1B", "type": "synonym", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#names_and_taxonomy" } ] }, { "name": "Neuralized-like protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase NEURL1B", "type": "synonym", "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525#function" }, { "database": "UniProtKB", "id": "ARBA00054526", "url": "https://www.uniprot.org/uniprotkb/ARBA00054526#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEURL1B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525", "locus": { "chromosome": "20", "start_pos": 4449472, "end_pos": 4407970, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001429", "url": "https://www.ensembl.org/id/ENSBTAG00000001429" } ] } } ], "crossref": [ { "id": "A0AAA9S525", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S525", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001429", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001429", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16786", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16786", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510912", "url": "https://www.ncbi.nlm.nih.gov/gene/510912", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510912", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510912", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHDNANF", "url": "https://omabrowser.org/oma/group/SHDNANF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MPM5", "url": "https://www.orthodb.org/?gene=F1MPM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12429", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12429", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12429:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12429:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07177", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07177", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696317", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696317", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S525-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQC9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQC9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPM5", "url": "https://www.uniprot.org/uniprotkb/F1MPM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPM5-1", "url": "https://www.uniprot.org/uniprotkb/F1MPM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTVHRTLPESSPPARLLATRPCCGPGPERRPVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESGFADTLTPARLGQARFSACLPPSSHDAANFDNNELENNQVVAKLGHLALGRAPGPAPADHAAAAIPCGPRERQRPSSSPALLEADLRFHATRGPDVSLSLDRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGGLRPAELPADPDALIDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLGVNGRPRGRLLCVDTTQALWAFFAVRGGAAGQLRLLGTLQSSPATTSPSGSLSGSQDDSDSDMAFSVNQSSSASESSLVTAPSSPLSPPVSPVSSPPELVGSKSSECTVCFDGEVDTVIYTCGHMCLCHGCGLRLKRQARACCPICRRPIKDVIKTYRP", "length": 555, "header": "tr|A0AAA9S525-1|A0AAA9S525_BOVIN Isoform 1 of E3 ubiquitin-protein ligase NEURL1B OS=Bos taurus OX=9913 GN=NEURL1B PE=4 SV=1 CANONICAL=A0AAA9S525-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S525-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#A0AAA9S525-1", "sequence": { "sequence": "MGNTVHRTLPESSPPARLLATRPCCGPGPERRPVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESGFADTLTPARLGQARFSACLPPSSHDAANFDNNELENNQVVAKLGHLALGRAPGPAPADHAAAAIPCGPRERQRPSSSPALLEADLRFHATRGPDVSLSLDRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGGLRPAELPADPDALIDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLGVNGRPRGRLLCVDTTQALWAFFAVRGGAAGQLRLLGTLQSSPATTSPSGSLSGSQDDSDSDMAFSVNQSSSASESSLVTAPSSPLSPPVSPVSSPPELVGSKSSECTVCFDGEVDTVIYTCGHMCLCHGCGLRLKRQARACCPICRRPIKDVIKTYRP", "length": 555, "header": "tr|A0AAA9S525-1|A0AAA9S525_BOVIN Isoform 1 of E3 ubiquitin-protein ligase NEURL1B OS=Bos taurus OX=9913 GN=NEURL1B PE=4 SV=1 CANONICAL=A0AAA9S525-1" }, "locus": { "chromosome": "20", "start_pos": 4448468, "end_pos": 4408178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118294.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118294.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081040.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081040.1" } ] } }, { "isoform_ac": "A0ABI0NQC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#A0ABI0NQC9-1", "sequence": { "sequence": "MGNTVHRTLPESSPPARLLATRPCCGPGPERRPVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLGTLQSSPATTSPSGSLSGSQDDSDSDMAFSVNQSSSASESSLVTAPSSPLSPPVSPVSSPPELVGSKSSECTVCFDGEVDTVIYTCGHMCLCHGCGLRLKRQARACCPICRRPIKDVIKTYRP", "length": 315, "header": "tr|A0ABI0NQC9-1|A0ABI0NQC9_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=NEURL1B PE=4 SV=1 CANONICAL=A0AAA9S525-1" }, "locus": { "chromosome": "20", "start_pos": 4448468, "end_pos": 4408178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105519.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105519.1" } ] } }, { "isoform_ac": "F1MPM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525/entry#F1MPM5-1", "sequence": { "sequence": "MGNTVHRTLPESGFADTLTPARLGQARFSACLPPSSHDAANFDNNELENNQVVAKLGHLALGRAPGPAPADHAAAAIPCGPRERQRPSSSPALLEADLRFHATRGPDVSLSLDRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGGLRPAELPADPDALIDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLGVNGRPRGRLLCVDTTQALWAFFAVRGGAAGQLRLLGTLQSSPATTSPSGSLSGSQDDSDSDMAFSVNQSSSASESSLVTAPSSPLSPPVSPVSSPPELVGSKSSECTVCFDGEVDTVIYTCGHMCLCHGCGLRLKRQARACCPICRRPIKDVIKTYRP", "length": 373, "header": "tr|F1MPM5-1|A0AAA9S525_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase NEURL1B OS=Bos taurus OX=9913 GN=NEURL1B PE=4 SV=3 CANONICAL=A0AAA9S525-1" }, "locus": { "chromosome": "20", "start_pos": 4448468, "end_pos": 4408178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001872.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001872.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001872.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001872.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:510912", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510912", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QF54-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "neurl1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGNNGSFVVFSTQDTVCKTRVQWQCSSLQDASLQHRSVASRQYCTVSTSGAERRTSAPPVSIESPRFHPHAKGKNIRLDAHLRRATRKNSFCNGITFSQRPVRLYEKVRLRLSGVHTGWSGALRFGFTTLDPGELSLTDIPKYACPDLVTRPGYWAKALPERLAMRDNVLAFWADRHGRVFYSINDGEPILFHCGLSVGCPVWAIIDIYGITQEVTLLESTFAESVGASCLSTARLSAYLPQSNHDSANYSNNQLETNQAAAAKFATLQLSNYNQLIPCCSTSSTPSSSVQRPARSLSLPLDVDLHFHPVRGPDVVLSNDRTVACTHFLDSSRTLMFSDRPVRVGETLYLEVGHLGLPYFGALLFGMTSCDPGTLSAGELPADPELLLDRKEYWVVYRGFPVPTAGDVLSFTFLANGEVHHGVNGVARGRLLCVDSSQVLWAFFTLHGAVNRLRILGTVQASPPTSPSVSQGSSPDDSDSDLAFSVNRSSSASESSLVTAPSSPLSPPVSPSFSSSDAPLSNKSSECTVCFDQEVDTVIYTCGHMCLCNDCGQRLKRQINACCPICRRPIKDVIKTYRP", "length": 579 }, "evidence": [ { "id": "A0AAA9S525", "url": "https://omabrowser.org/oma/group/A0AAA9S525/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNTVHRTLPDPSPPARLLATRPCCGPGPERRPVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESAFADTLTPARLSQARFSACLPPSSHDAANFDNNELENNQVVAKLGHLALGRAPGPPPADAAAAAIPCGPRERPRPASSPALLEADLRFHATRGPDVSLSADRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGVLRPNELPADPDALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLGINGRPRGRLLCVDTTQALWAFFAVRGGVAGQLRLLGTLQSSPATTTPSGSLSGSQDDSDSDMTFSVNQSSSASESSLVTAPSSPLSPPVSPVFSPPEPAGIKNGECTVCFDGEVDTVIYTCGHMCLCHSCGLRLKRQARACCPICRRPIKDVIKIYRP", "length": 555 }, "evidence": [ { "id": "A0AAA9S525", "url": "https://omabrowser.org/oma/group/A0AAA9S525/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q0MW30-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "Neurl1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNTVHRTLPDSSPPARLLATRPCYGPGPERRAVLGEAPRFHAQAKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESTFADTLTPLRLGQARLSACPPPGSHDAANFDNNELENNQVVAKLGHLALGRPDAAVPCVARERPRPASSPALLDAELRFHATRGPDVSLSADRRLACAPRPDGGRTLVFSERPLRPGESLCVEVGRPGLAAPAAVAFGITSCDPGALRPSELPADPAALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLAVNGRPRGRLLCVDTSQALWAFFAVRGGVAGQLRLLGTLQSSSETMTPSGSFSGSQDDSDSDMTFGVNQSSSASESSLVTAPSSPLSPPVSPAFSAPEPTGSRNGECTVCFDSEVDTVIYTCGHMCLCHGCGLRLRRQARACCPICRRPIKDVIKIYRP", "length": 546 }, "evidence": [ { "id": "A0AAA9S525", "url": "https://omabrowser.org/oma/group/A0AAA9S525/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "pmid": "" }, { "name": "ubiquitin-dependent endocytosis", "id": "GO:0070086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S525", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" }, { "id": "PS51065", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51065" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NHR", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 194, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S525" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 503, "end_pos": 543, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 464, "end_pos": 466 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S528-1", "uniprot_ac": "A0AAA9S528", "uniprot_id": "A0AAA9S528_BOVIN", "mass": { "chemical_mass": 40948.0, "monoisotopic_mass": 40948.0 }, "refseq": { "ac": "XP_024835201", "name": "zinc finger protein 239 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835201" }, "gene_names": [ { "name": "LOC100296121", "type": "recommended", "evidence": [ { "id": "A0AAA9S528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ] }, { "name": "LOC100296121", "type": "synonym", "evidence": [ { "id": "XP_024835201", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835201" } ] } ], "protein_names": [ { "name": "C2H2-type domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 239 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024835201", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835201" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100296121", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528", "locus": {} } ], "crossref": [ { "id": "A0AAA9S528", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S528", "database": "AlphaFoldDB", "categories": [] }, { "id": "100296121", "url": "https://www.ncbi.nlm.nih.gov/gene/100296121", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024835201", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835201", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S528-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNLALEGGLCGPEVLRTNPGQTLCGTDVKSHQHGGEKLMRRDWGKALMKNCTVHALEKAFMCQEARKDFPGTSDHVQHQVKPQMMEFVAEFHNGEKRFKCSECGKLFYRKSRLAQHHRVHTGEKPYECSECGKVFRCSSSLAIHRRIHTGERPYECRECGKFFRQHSQLVVHQRIHTGARPYECSECGKTFSTKTKLDQHWRVHTRERPYECEECGRTYNCKRMLDQHQRVHTGEWPYECSECGKAFRYFSSLFMHRRIHSGERPYECSECGKSFRQKAHLQGHQRIHSGAKTFECSECGRCFSQKSVLTKHQRVHTEERPYMCSECGKCFRDRTSLIKHLNLHWRKAT", "length": 350, "header": "tr|A0AAA9S528-1|A0AAA9S528_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC100296121 PE=3 SV=1 CANONICAL=A0AAA9S528-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S528-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528/entry#A0AAA9S528-1", "sequence": { "sequence": "MGNLALEGGLCGPEVLRTNPGQTLCGTDVKSHQHGGEKLMRRDWGKALMKNCTVHALEKAFMCQEARKDFPGTSDHVQHQVKPQMMEFVAEFHNGEKRFKCSECGKLFYRKSRLAQHHRVHTGEKPYECSECGKVFRCSSSLAIHRRIHTGERPYECRECGKFFRQHSQLVVHQRIHTGARPYECSECGKTFSTKTKLDQHWRVHTRERPYECEECGRTYNCKRMLDQHQRVHTGEWPYECSECGKAFRYFSSLFMHRRIHSGERPYECSECGKSFRQKAHLQGHQRIHSGAKTFECSECGRCFSQKSVLTKHQRVHTEERPYMCSECGKCFRDRTSLIKHLNLHWRKAT", "length": 350, "header": "tr|A0AAA9S528-1|A0AAA9S528_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC100296121 PE=3 SV=1 CANONICAL=A0AAA9S528-1" }, "locus": { "chromosome": "18", "start_pos": 64572891, "end_pos": 64571842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154452.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154452.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106851.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106851.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S528", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S528" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 126, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S547-1", "uniprot_ac": "A0AAA9S547", "uniprot_id": "A0AAA9S547_BOVIN", "mass": { "chemical_mass": 35323.0, "monoisotopic_mass": 35323.0 }, "refseq": { "ac": "XP_010801439", "name": "lymphocyte function-associated antigen 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801439" }, "gene_names": [ { "name": "CD58", "type": "recommended", "evidence": [ { "id": "A0AAA9S547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ] }, { "name": "CD58", "type": "synonym", "evidence": [ { "id": "XP_010801439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801439" } ] } ], "protein_names": [ { "name": "CD58 molecule", "type": "synonym", "evidence": [ { "id": "A0AAA9S547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547/entry#names_and_taxonomy" } ] }, { "name": "lymphocyte function-associated antigen 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010801439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801439" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547", "locus": { "chromosome": "3", "start_pos": 26773151, "end_pos": 26709231, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040131", "url": "https://www.ensembl.org/id/ENSBTAG00000040131" } ] } } ], "crossref": [ { "id": "A0AAA9S547", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S547", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040131", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040131", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05775", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05775", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782186", "url": "https://www.ncbi.nlm.nih.gov/gene/782186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6PZJ9", "url": "https://www.orthodb.org/?gene=F6PZJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12080", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12080", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12080:SF55", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12080:SF55", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202733", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010801439", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S547-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZJ9", "url": "https://www.uniprot.org/uniprotkb/F6PZJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZJ9-1", "url": "https://www.uniprot.org/uniprotkb/F6PZJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGTTGTRTESARRGKDRRPDCIRCQPAARQAGRGGARRGARGGAGRERRGGAREAGLALRQTELCGCEPLAETARTAMAAGSAPGWALGVLGVVYLFLKLDFISCSQEIYGAMNGNVTFYVSKFHPSTEIIWKKEKNKVVEWDIQSGLEAFQSFKDRVYLDIGSGNLTITRLTKSDEGLYELESPGVRNKSEFHLKVIAPPPSPSTFCSLSDDGNITLTCEIMEAGYDIDGNLLQYSWECPPTVQCHRGLSPSEAYVLKKSDLSQNVQCIVSNPLFRTSASISLSTCVPEDNTRHRYVLFAILPAVICGLLFLKCFLGRHSQ", "length": 323, "header": "tr|A0AAA9S547-1|A0AAA9S547_BOVIN Isoform 1 of CD58 molecule OS=Bos taurus OX=9913 GN=CD58 PE=4 SV=1 CANONICAL=A0AAA9S547-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S547-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547/entry#A0AAA9S547-1", "sequence": { "sequence": "MAGTTGTRTESARRGKDRRPDCIRCQPAARQAGRGGARRGARGGAGRERRGGAREAGLALRQTELCGCEPLAETARTAMAAGSAPGWALGVLGVVYLFLKLDFISCSQEIYGAMNGNVTFYVSKFHPSTEIIWKKEKNKVVEWDIQSGLEAFQSFKDRVYLDIGSGNLTITRLTKSDEGLYELESPGVRNKSEFHLKVIAPPPSPSTFCSLSDDGNITLTCEIMEAGYDIDGNLLQYSWECPPTVQCHRGLSPSEAYVLKKSDLSQNVQCIVSNPLFRTSASISLSTCVPEDNTRHRYVLFAILPAVICGLLFLKCFLGRHSQ", "length": 323, "header": "tr|A0AAA9S547-1|A0AAA9S547_BOVIN Isoform 1 of CD58 molecule OS=Bos taurus OX=9913 GN=CD58 PE=4 SV=1 CANONICAL=A0AAA9S547-1" }, "locus": { "chromosome": "3", "start_pos": 26744565, "end_pos": 26709430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109705.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109705.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078977.1" } ] } }, { "isoform_ac": "F6PZJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547/entry#F6PZJ9-1", "sequence": { "sequence": "MAGTTGTRTESARRGKDRRPDCIRCQPAARQAGRGGAGRERRGGAREAGLALRQTELCGCEPLAETARTAMAAGSAPGWALGVLGVVYLFLKLDFISCSQEIYGAMNGNVTFYVSKFHPSTEIIWKKEKNKVVEWDIQSGLEAFQSFKDRVYLDIGSGNLTITRLTKSDEGLYELESPGVRNKSEFHLKVIAPPPSPSTFCSLSDDGNITLTCEIMEAGYDIDGNLLQYSWECPPTVQCHRGLSPSEAYVLKKSDLSQNVQCIVSNPLFRTSASISLSTCVPEDNTRHRYVLFAILPAVICGLLFLKCFLGRHSQ", "length": 315, "header": "tr|F6PZJ9-1|F6PZJ9_BOVIN Computationally mapped isoform of CD58 molecule OS=Bos taurus OX=9913 GN=CD58 PE=4 SV=2 CANONICAL=A0AAA9S547-1" }, "locus": { "chromosome": "3", "start_pos": 26744565, "end_pos": 26709430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023836.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023836.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023836.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023836.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-202733", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202733", "resource": "Reactome", "description": "Cell surface interactions at the vascular wall" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ], "pmid": "" }, { "name": "heterotypic cell-cell adhesion", "id": "GO:0034113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034113", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S547", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S547" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 216, "end_pos": 218 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S570-1", "uniprot_ac": "A0AAA9S570", "uniprot_id": "A0AAA9S570_BOVIN", "mass": { "chemical_mass": 15470.0, "monoisotopic_mass": 15470.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Immunoglobulin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S570", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570", "locus": {} } ], "crossref": [ { "id": "A0AAA9S570", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S570", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S570", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S570-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SSNMEEDKLSVMRATGSSIVIDCDLTGSYIHWYKFQEGAVPRRLLYYDVSNSKAVLDSGISEGKYHAYKGTGKSYTFVISNLQESDSGTYYCAVWEKHIGLDFLYTALEILLVAAKTALIHRIDQPLSHFLPQFFLL", "length": 137, "header": "tr|A0AAA9S570-1|A0AAA9S570_BOVIN Isoform 1 of Immunoglobulin domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S570-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S570-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570/entry#A0AAA9S570-1", "sequence": { "sequence": "SSNMEEDKLSVMRATGSSIVIDCDLTGSYIHWYKFQEGAVPRRLLYYDVSNSKAVLDSGISEGKYHAYKGTGKSYTFVISNLQESDSGTYYCAVWEKHIGLDFLYTALEILLVAAKTALIHRIDQPLSHFLPQFFLL", "length": 137, "header": "tr|A0AAA9S570-1|A0AAA9S570_BOVIN Isoform 1 of Immunoglobulin domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S570-1" }, "locus": { "chromosome": "4", "start_pos": 82619466, "end_pos": 82619056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125518.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125518.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081085.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081085.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S570", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S570", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S570" }, { "id": "SM00409", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 111, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S591-1", "uniprot_ac": "A0AAA9S591", "uniprot_id": "A0AAA9S591_BOVIN", "mass": { "chemical_mass": 11605.0, "monoisotopic_mass": 11605.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S591", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591", "locus": {} } ], "crossref": [ { "id": "A0AAA9S591", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S591", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S591", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S591-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQKVTQDQPQVLGQEKEAVTLDCKYDTSDSRYSLFWYKQPSSGGMILLIRQDSSNQQNATEGRYSLNFQKARKSITLVISASQLEHSAVYFCALREPTVRRV", "length": 102, "header": "tr|A0AAA9S591-1|A0AAA9S591_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S591-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S591-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591/entry#A0AAA9S591-1", "sequence": { "sequence": "AQKVTQDQPQVLGQEKEAVTLDCKYDTSDSRYSLFWYKQPSSGGMILLIRQDSSNQQNATEGRYSLNFQKARKSITLVISASQLEHSAVYFCALREPTVRRV", "length": 102, "header": "tr|A0AAA9S591-1|A0AAA9S591_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S591-1" }, "locus": { "chromosome": "10", "start_pos": 22984742, "end_pos": 22984437, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124861.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124861.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080343.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080343.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S591", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S591", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S591" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 102, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S596-1", "uniprot_ac": "A0AAA9S596", "uniprot_id": "A0AAA9S596_BOVIN", "mass": { "chemical_mass": 1103.0, "monoisotopic_mass": 1103.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S596", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S596/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S596", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S596" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S596", "locus": {} } ], "crossref": [ { "id": "A0AAA9S596", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S596", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S596-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S596-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKKRRKK", "length": 8, "header": "tr|A0AAA9S596-1|A0AAA9S596_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S596-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S596-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S596/entry#A0AAA9S596-1", "sequence": { "sequence": "MEKKRRKK", "length": 8, "header": "tr|A0AAA9S596-1|A0AAA9S596_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S596-1" }, "locus": { "chromosome": "18", "start_pos": 10425078, "end_pos": 10425055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117809.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117809.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080349.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080349.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S597-1", "uniprot_ac": "A0AAA9S597", "uniprot_id": "A0AAA9S597_BOVIN", "mass": { "chemical_mass": 53823.0, "monoisotopic_mass": 53823.0 }, "refseq": {}, "gene_names": [ { "name": "GNPTG", "type": "recommended", "evidence": [ { "id": "A0AAA9S597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597" } ] } ], "protein_names": [ { "name": "N-acetylglucosamine-1-phosphate transferase subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9S597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S597", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNPTG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597", "locus": { "chromosome": "25", "start_pos": 1083886, "end_pos": 1072063, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014118", "url": "https://www.ensembl.org/id/ENSBTAG00000014118" } ] } } ], "crossref": [ { "id": "A0AAA9S597", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S597", "database": "AlphaFoldDB", "categories": [] }, { "id": "508713", "url": "https://www.ncbi.nlm.nih.gov/gene/508713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12630:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12630:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07915", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07915", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13015", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13015", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S597", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S597-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "EESEQAHSVSPHPVLSSLPVCGGHVLGAHGAEHEAAEPVAQAQAAHQPQAGQLAAGAAPGVAVAQLPHGQRAGQLRRARAAPVLRGLWLHGRCGGQRREPGLRRGSAARPSAPNRITPHSPRSAAPTSSAKASRERPAGRRARPPSAPCPREALRRPIARSRAHYAYRVSAPPAAKLCAGTISGSGPHVTARRGATSDSGSHVTARRRRRDGGEAGGLGGGARVRGPRARARRRRQDEGGGGAQHFRAQQPVPAPDQSPPAQEGPFTRVWYKYELCPFHNVTQHEQTFRWNAYSGILGIWHEWEITNNTFRGMWMRDGDACQSRSRQSKVELTCGKSNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLPAALQQRWDQLEQDLVDELITAQGYEKSLRAIFEDAGYLKTSEPNEAAQQEGGTKGLRFETLESCQEAHKALSQEIKRLQGVLTQHGVPYGKPTETPSSEHWGPQVPTAGMAEPLRGDPGLRGDTL", "length": 498, "header": "tr|A0AAA9S597-1|A0AAA9S597_BOVIN Isoform 1 of N-acetylglucosamine-1-phosphate transferase subunit gamma OS=Bos taurus OX=9913 GN=GNPTG PE=4 SV=1 CANONICAL=A0AAA9S597-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S597-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597/entry#A0AAA9S597-1", "sequence": { "sequence": "EESEQAHSVSPHPVLSSLPVCGGHVLGAHGAEHEAAEPVAQAQAAHQPQAGQLAAGAAPGVAVAQLPHGQRAGQLRRARAAPVLRGLWLHGRCGGQRREPGLRRGSAARPSAPNRITPHSPRSAAPTSSAKASRERPAGRRARPPSAPCPREALRRPIARSRAHYAYRVSAPPAAKLCAGTISGSGPHVTARRGATSDSGSHVTARRRRRDGGEAGGLGGGARVRGPRARARRRRQDEGGGGAQHFRAQQPVPAPDQSPPAQEGPFTRVWYKYELCPFHNVTQHEQTFRWNAYSGILGIWHEWEITNNTFRGMWMRDGDACQSRSRQSKVELTCGKSNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLPAALQQRWDQLEQDLVDELITAQGYEKSLRAIFEDAGYLKTSEPNEAAQQEGGTKGLRFETLESCQEAHKALSQEIKRLQGVLTQHGVPYGKPTETPSSEHWGPQVPTAGMAEPLRGDPGLRGDTL", "length": 498, "header": "tr|A0AAA9S597-1|A0AAA9S597_BOVIN Isoform 1 of N-acetylglucosamine-1-phosphate transferase subunit gamma OS=Bos taurus OX=9913 GN=GNPTG PE=4 SV=1 CANONICAL=A0AAA9S597-1" }, "locus": { "chromosome": "25", "start_pos": 1082995, "end_pos": 1072262, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110472.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110472.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081116.1" } ] } }, { "isoform_ac": "A0AAA9TCK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597/entry#A0AAA9TCK1-1", "sequence": { "sequence": "EESEQAHSVSPHPVLSSLPVCGGHVLGAHGAEHEAAEPVAQAQAAHQPQAGQLAAGAAPGVAVAQLPHGQRAGQLRRARAAPVLRGLWLHGRCGGQRREPGLRRGSAARPSAPNRITPHSPRSAAPTSSAKASRERPAGRRARPPSAPCPREALRRPIARSRAHYAYRVSAPPAAKLCAGTISGSGPHVTARRGATSDSGSHVTARRRRRDGGEAGGLGGGARVRGPRARARRRRQDEGGGGAQHFRAQQPVPAPDQSPPAQEGPFTRVWPRAPLQTLWQVLQPGGVHVQVRALPVPQRDAARADLPLERLQRDPRVELTCGKSNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLPAALQQRWDQLEQDLVDELITAQGYEKSLRAIFEDAGYLKTSEPNEAAQQEGGTKGLRFETLESCQEAHKALSQEIKRLQGVLTQHGVPYGKPTETPSSEHWGPQVPTAGMAEPLRGDPGLRGDTL", "length": 485, "header": "tr|A0AAA9TCK1-1|A0AAA9TCK1_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphate transferase subunit gamma OS=Bos taurus OX=9913 GN=GNPTG PE=4 SV=1 CANONICAL=A0AAA9S597-1" }, "locus": { "chromosome": "25", "start_pos": 1082995, "end_pos": 1072262, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117417.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117417.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093852.1" } ] } }, { "isoform_ac": "A0AAA9TYR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597/entry#A0AAA9TYR3-1", "sequence": { "sequence": "MAARLAGLAVVLGFAARGPAPGGAAKMKVVEEPNTFGLNNPFLPQTSRLQPKRDPSPVSGPAHLSRLSGKCFSLVESTIWHEWEITNNTFRGMWMRDGDACQSRSRQSKVELTCGKSNRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLPAALQQRWDQLEQDLVDELITAQGYEKSLRAIFEDAGYLKTSEPNEAAQQEGGTKGLRFETLESCQEAHKALSQEIKRLQGVLTQHGVPYGKPTETPSSEHWGPQVPTAGMAEPLRGDPGLRGDTL", "length": 278, "header": "tr|A0AAA9TYR3-1|A0AAA9TYR3_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphate transferase subunit gamma OS=Bos taurus OX=9913 GN=GNPTG PE=4 SV=1 CANONICAL=A0AAA9S597-1" }, "locus": { "chromosome": "25", "start_pos": 1082995, "end_pos": 1072893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018766.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018766.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103486.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S597", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S597", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597" }, { "id": "PS51912", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51912" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DMAP1-binding", "eco_id": "ECO_0000259", "start_pos": 368, "end_pos": 471, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S597" }, { "id": "PS51914", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51914" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MRH", "eco_id": "ECO_0000259", "start_pos": 262, "end_pos": 363, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 280, "end_pos": 282 }, { "start_pos": 307, "end_pos": 309 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S598-1", "uniprot_ac": "A0AAA9S598", "uniprot_id": "A0AAA9S598_BOVIN", "mass": { "chemical_mass": 63819.0, "monoisotopic_mass": 63819.0 }, "refseq": { "ac": "NP_001421930", "name": "ubiquilin-4 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421930" }, "gene_names": [ { "name": "UBQLN4", "type": "recommended", "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ] }, { "name": "UBQLN4", "type": "synonym", "evidence": [ { "id": "NP_001421930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421930" } ] } ], "protein_names": [ { "name": "Ubiquilin-4", "type": "recommended", "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598/entry#names_and_taxonomy" } ] }, { "name": "Ataxin-1 interacting ubiquitin-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598/entry#names_and_taxonomy" } ] }, { "name": "Ataxin-1 ubiquitin-like-interacting protein A1U", "type": "synonym", "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598/entry#names_and_taxonomy" } ] }, { "name": "Connexin43-interacting protein of 75 kDa", "type": "synonym", "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598/entry#names_and_taxonomy" } ] }, { "name": "ataxin-1 ubiquitin-like interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001421930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421930" } ] }, { "name": "ubiquilin-4 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421930" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBQLN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598", "locus": { "chromosome": "3", "start_pos": 14728061, "end_pos": 14713342, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001548", "url": "https://www.ensembl.org/id/ENSBTAG00000001548" } ] } } ], "crossref": [ { "id": "A0AAA9S598", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S598", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001548", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001548", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01808", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01808", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14399", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14399", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533021", "url": "https://www.ncbi.nlm.nih.gov/gene/533021", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EVRFQTQ", "url": "https://omabrowser.org/oma/group/EVRFQTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6D3", "url": "https://www.orthodb.org/?gene=F1N6D3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10677", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10677", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10677:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10677:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00627", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00627", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23195", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23195", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S598-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6D3", "url": "https://www.uniprot.org/uniprotkb/F1N6D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6D3-1", "url": "https://www.uniprot.org/uniprotkb/F1N6D3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKVQDPATATASSPSTPDPASAPSTTPASPATSAQPSTSGSATSDTGSGSRRGSGGGTSPGTGEGPPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPASQAPGSGGEGAGGSGASRVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGMARPPASSAGSNAGSAPEAPTSSPALPVTSSPAGASSAQQQLMQQMIQLLAGSGSSQVQTPEVRFQQQLEQLNSMGFINHEANLQALIATGGDINAAIERLLGSQLS", "length": 601, "header": "tr|A0AAA9S598-1|A0AAA9S598_BOVIN Isoform 1 of Ubiquilin-4 OS=Bos taurus OX=9913 GN=UBQLN4 PE=4 SV=1 CANONICAL=A0AAA9S598-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S598-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598/entry#A0AAA9S598-1", "sequence": { "sequence": "MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKVQDPATATASSPSTPDPASAPSTTPASPATSAQPSTSGSATSDTGSGSRRGSGGGTSPGTGEGPPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPASQAPGSGGEGAGGSGASRVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGMARPPASSAGSNAGSAPEAPTSSPALPVTSSPAGASSAQQQLMQQMIQLLAGSGSSQVQTPEVRFQQQLEQLNSMGFINHEANLQALIATGGDINAAIERLLGSQLS", "length": 601, "header": "tr|A0AAA9S598-1|A0AAA9S598_BOVIN Isoform 1 of Ubiquilin-4 OS=Bos taurus OX=9913 GN=UBQLN4 PE=4 SV=1 CANONICAL=A0AAA9S598-1" }, "locus": { "chromosome": "3", "start_pos": 14727057, "end_pos": 14713357, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101122.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101122.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077335.1" } ] } }, { "isoform_ac": "F1N6D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598/entry#F1N6D3-1", "sequence": { "sequence": "MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKVQDPATATASSPSTPDPASAPSTTPASPATSAQPSTSGSATSDTGSGSRRGSGGGTSPGTGEGPPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPASQAPGSGGEGAGGSGASRVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGMARPPASSAGSNAGSAPEAPTSSPALPVTSSPAGASSAQQQLMQQMIQLLAGSGSSQVQTPEVRFQQQLEQLNSMGFINHEANLQALIATGGDINAAIERLLGSQLS", "length": 573, "header": "tr|F1N6D3-1|F1N6D3_BOVIN Computationally mapped isoform of Ubiquilin-4 OS=Bos taurus OX=9913 GN=UBQLN4 PE=4 SV=3 CANONICAL=A0AAA9S598-1" }, "locus": { "chromosome": "3", "start_pos": 14727057, "end_pos": 14713357, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002028.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002028.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002028.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002028.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 101, "start_aa": "Thr", "end_pos": 101, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr101", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 515, "start_aa": "Thr", "end_pos": 515, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr515", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P624-1", "protein_name": "Ubiquilin-4", "gene_name": "UBQLN4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEPSGGGGPGPGGPELGGPGGALIRVTVKTPKDKEEIVIADGASVREFKEEISRRFKAKQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKVQDPTSAASAPGAASAPTATSPSPAAPSQPSTSSSAAPDAGSGSRRSSGSGTLGGPGDGGPNSATSILSGFGGITGLGNLGMGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQNMMSNPDLMRQMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLTGNSESSSSQPLRTENREPLPNPWSPSPPASQSQAPSSEGSTGSGSTQSTPTVSNPFGLNAASFGAGMFNSPEMQGLLQQISENPQLMQNMISAPYMRSMMQTLAQNPDFAAQIMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPDSLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGMPRMPPSSTGGSTIPENPVPSASTPASASPAGGGNPQQQLMQQMIQLLAGGSSQAQSPEVRFQQQLEQLNAMGFINREANLQALIATGGDINAAIERLLGSQPS", "length": 606 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A480Y2F0-1", "protein_name": "Ubiquilin-4", "gene_name": "UBQLN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDQTTATASSPSTPDPASAPSTTPASPATPAQPSTSGSAASDTGSGSRRSSGGGPSPGTGEGPPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGMSRTPAPSAGSSAGSAPEAPTSSPAAPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAAIERLLGSQLS", "length": 601 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A3P1-1", "protein_name": "Ubiquilin-4", "gene_name": "Ubqln4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEPSGAETRPQIRVTVKTPKDKEEILICDQASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDPVTTTASSPSTPDSASAPSTTPASPAAPVQPCSSGNTTSDASSGGGPSPVAAEGPSNATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESVPGGYNALRRMYTDIQEPMFTAAREQFGNNPFSSLAGNSDNSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRTMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGTPRTSVPLAGSNSGSAAEAPTASPGTPATTPPSAGSNTQQQLMQQMIQLLSGSGNSQVPVPEVRFQQQLEQLNSMGFVNREANLQALIATGGDINAAIERLLGSQLS", "length": 595 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99NB8-1", "protein_name": "Ubiquilin-4", "gene_name": "Ubqln4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEPSGAETRPQIRVTVKTPKDKEEIVICDQASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLSQHGIKDGLTVHLVIKTPQKAQDPVTAAASPPSTPDSASAPSTTPASPAAAPVQPCSSGNTTSDAGSGGGPSPVAAEGPSSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESVPGGYNALRRMYTDIQEPMFTAAREQFGNNPFSSLAGNSDNSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRTMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGTPRTSVPLAGSNSGSSAEAPTSSPGVPATSPPSAGSNAQQQLMQQMIQLLSGSGNSQVPMPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAAIERLLGSQLS", "length": 596 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NIF3-1", "protein_name": "Ubiquilin", "gene_name": "ubqln", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVKINIKSSTDNKFDVDVELGITVADFKKVIATKCSIPADQQRIIYSGRILKDHQTLDEIKIQDGHTVHLVKGAAPPPPPPVEQQVPTPSNTQPQGIPGVPQNINDMMNNPMIQEMFNSRMMDSLLDNPDIFRDMMMGNPEMREVLNNNPEMAQMLSDPRQLRQSLEMMRNPELMREMMRNADRAMINIENHPEGFNLLRRMYTDIQEPLMNAANQQAASQNQTNSNPIQTNTDANPNSQPLPNPWSTNSSSTSSNPTSSSPSSRPTTGSSTNTGASNPWASMFSGGGGGMGGGTNNTGTNNTGSTNNTGASNPWASMFGGGGGGMGGMGGMEGMLGMDPERVQQLLNNPVAQQMMQRLMSDPAMMQQMITMNPQLRQMMDSNPQLREAMNNPEFLNMMTNPENMNAMMQLQQAMGTLRNNGVFPGGMGGMGGMGGMGGMGGMGGMDFSQFGNMFGGMGGMGGMGNNNSSTTRPPVNQEPPEQRFRLQLEQLEELGFVDRAANISALTSTNGNINLAIDRLLR", "length": 523 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9NRR5-1", "protein_name": "Ubiquilin-4", "gene_name": "UBQLN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAAIERLLGSQLS", "length": 601 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SII9-1", "protein_name": "Ubiquitin domain-containing protein DSK2a", "gene_name": "DSK2A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGGEADSRQPLTAEGVAVAVNVRCSNGTKFSVTTSLDSTVESFKELIAQNSDVPANQQRLIYKGRILKDDQTLLSYGLQADHTVHMVRGFVPSSPSAPAANAGNQTTAPQAVGSNDSSNLGGGESLFPGLGFNPLGGGNAMAGLFGSGLPDLEQAQQQLAQNPNMIREMMNTPAIQNLMNNPEFMRSMIMNNPQMRELVDRNPELGHVLNDPSILRQTLEAARNPELMREMMRNTDRAMSNIESMPEGFNMLRRMYENVQEPLMNATTMSENAGNNTSSNPFAALLGNQGVTTQGSDTSNNISAPNAETGTPNANPLPNPWGATAGQTTAPGRTNAGLGGLGGLGGLGGLGMLGADSPLGATPDASQLSQILQNPAMSQMMQSVLSNPQYMNQLMSLNPQLRSMLDMNPQLREMMQNPDFLRQFSSPEMMQQMMSLQQSLFSQNRNTAGQDPTQTGAATGTANNGGLDLLMNMFGSLGAGGLSGTNQPNVPPEERFATQLQQLQEMGFYDRAENIRALLATNGNVNAAVERLLGSIGQ", "length": 538 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VWD9-1", "protein_name": "Ubiquilin-like protein", "gene_name": "Ubqn", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAEGGSKRINVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTDTLQMHNIKDNLTVHLVIKAPTRNNEQPARQPADVRQTPFGLNQFGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPWGGANSGTNGTVGGSGAGNPTGDLPPNNVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAARLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSGASTNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSNNADNTQPPEVRYQSQLEQLNAMGFVNRDANLQALIATFGDINAAVERLLSLNQLSLS", "length": 547 }, "evidence": [ { "id": "A0AAA9S598", "url": "https://omabrowser.org/oma/group/A0AAA9S598/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of autophagosome maturation", "id": "GO:1901097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901097", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032434", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "K48-linked polyubiquitin modification-dependent protein binding", "id": "GO:0036435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036435", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "polyubiquitin modification-dependent protein binding", "id": "GO:0031593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "cytosolic proteasome complex", "id": "GO:0031597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "nuclear proteasome complex", "id": "GO:0031595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031595", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S598", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" }, { "id": "PS50030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA", "eco_id": "ECO_0000259", "start_pos": 553, "end_pos": 598, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S598" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 87, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 101, 515 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5A2-1", "uniprot_ac": "A0AAA9S5A2", "uniprot_id": "A0AAA9S5A2_BOVIN", "mass": { "chemical_mass": 35973.0, "monoisotopic_mass": 35973.0 }, "refseq": { "ac": "NP_001377151", "name": "olfactory receptor family 12 subfamily D member 23", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377151" }, "gene_names": [ { "name": "OR12D23", "type": "recommended", "evidence": [ { "id": "A0AAA9S5A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2" } ] }, { "name": "OR12D23", "type": "synonym", "evidence": [ { "id": "NP_001377151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377151" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S5A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 12 subfamily D member 23", "type": "synonym", "evidence": [ { "id": "NP_001377151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377151" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377151" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR12D23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2", "locus": { "chromosome": "23", "start_pos": 29271030, "end_pos": 29271983, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057287", "url": "https://www.ensembl.org/id/ENSBTAG00000057287" } ] } } ], "crossref": [ { "id": "A0AAA9S5A2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5A2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15915", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15915", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616306", "url": "https://www.ncbi.nlm.nih.gov/gene/616306", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616306", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616306", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377151", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5A2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLFCLFFQVMLNRTSVTEFLLLPVTDIQVLQPVLFVVFLAIYIVNVAGNGAILMVVTSDPRLHSPMYFFLGNLACIDICFSTVSLPKMLENFLSTHKAISFLGCISQLHFFHFMGSTEAMLLAVMGFDRFVAICKPLHYTLIMNHQVCIQMAVTVWIIGFFHALLHSVMTSRLNFCDSNQINHFFCDVKPLLKLACGNTELNWWLVNNVTGTIATGACFLTFLSYFYIIIYLFFKTHSCRMLRKALSTCASHFVVVVLFHVPGVFVYIHPASSSSMDQDQISALMYNGVTPVLNPLIYTLRNKEVKRALRRVISRSQ", "length": 317, "header": "tr|A0AAA9S5A2-1|A0AAA9S5A2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR12D23 PE=3 SV=1 CANONICAL=A0AAA9S5A2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5A2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2/entry#A0AAA9S5A2-1", "sequence": { "sequence": "MLFCLFFQVMLNRTSVTEFLLLPVTDIQVLQPVLFVVFLAIYIVNVAGNGAILMVVTSDPRLHSPMYFFLGNLACIDICFSTVSLPKMLENFLSTHKAISFLGCISQLHFFHFMGSTEAMLLAVMGFDRFVAICKPLHYTLIMNHQVCIQMAVTVWIIGFFHALLHSVMTSRLNFCDSNQINHFFCDVKPLLKLACGNTELNWWLVNNVTGTIATGACFLTFLSYFYIIIYLFFKTHSCRMLRKALSTCASHFVVVVLFHVPGVFVYIHPASSSSMDQDQISALMYNGVTPVLNPLIYTLRNKEVKRALRRVISRSQ", "length": 317, "header": "tr|A0AAA9S5A2-1|A0AAA9S5A2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR12D23 PE=3 SV=1 CANONICAL=A0AAA9S5A2-1" }, "locus": { "chromosome": "23", "start_pos": 29271983, "end_pos": 29271033, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115592.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115592.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081121.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616306", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616306", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 298, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 208, "end_pos": 210 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5C2-1", "uniprot_ac": "A0AAA9S5C2", "uniprot_id": "A0AAA9S5C2_BOVIN", "mass": { "chemical_mass": 5697.0, "monoisotopic_mass": 5697.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S5C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C2", "locus": {} } ], "crossref": [ { "id": "A0AAA9S5C2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5C2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR057129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF23701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERAGVPTLSPRRSSVEAKIQSTSCSVRKSSTVTAWPAVELLLSWGQRRGTH", "length": 52, "header": "tr|A0AAA9S5C2-1|A0AAA9S5C2_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S5C2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C2/entry#A0AAA9S5C2-1", "sequence": { "sequence": "MERAGVPTLSPRRSSVEAKIQSTSCSVRKSSTVTAWPAVELLLSWGQRRGTH", "length": 52, "header": "tr|A0AAA9S5C2-1|A0AAA9S5C2_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S5C2-1" }, "locus": { "chromosome": "5", "start_pos": 29928242, "end_pos": 29928087, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095739.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095739.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078434.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078434.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5G0-1", "uniprot_ac": "A0AAA9S5G0", "uniprot_id": "A0AAA9S5G0_BOVIN", "mass": { "chemical_mass": 34609.0, "monoisotopic_mass": 34609.0 }, "refseq": { "ac": "NP_001376970", "name": "olfactory receptor family 4 subfamily A member 2H", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970" }, "gene_names": [ { "name": "OR4A2H", "type": "recommended", "evidence": [ { "id": "A0AAA9S5G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0" } ] }, { "name": "OR4A2H", "type": "synonym", "evidence": [ { "id": "NP_001376970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970" } ] }, { "name": "OR4C15", "type": "synonym", "evidence": [ { "id": "NP_001376970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S5G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 4 subfamily A member 2H", "type": "synonym", "evidence": [ { "id": "NP_001376970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970" } ] }, { "name": "olfactory receptor, family 4, subfamily C, member 15", "type": "synonym", "evidence": [ { "id": "NP_001376970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4A2H", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0", "locus": { "chromosome": "15", "start_pos": 702875, "end_pos": 701958, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064892", "url": "https://www.ensembl.org/id/ENSBTAG00000064892" } ] } } ], "crossref": [ { "id": "A0AAA9S5G0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5G0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522410", "url": "https://www.ncbi.nlm.nih.gov/gene/522410", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522410", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522410", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376970", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METRNNVTEFVLLGLTQRNQGQKILFVLFLLIYIVTMVGTLLIVLTVVFSPTLDVPMYFFLGYLSFMDAVYATTVNPNTFTDLLYEKKTISFQACMIQLFTEHLFGGAEILLLVIMAYDRYVAICKPLHYVTIMNKRVCVLLLLLAWVGGLLHAIVNILFVYYLPFCGPNVIDHFICAMYPLLKLACTDTHSIAIIVVANDGIICVVLFMLLLMSYGAILHSLKNISQEGRRKALSICGSHITVVLLFFVPCIFLYVRPPSILPIDKSLAVFYTIITPMLNPLIYTLRNSEMQHAMGKLWIRKRT", "length": 305, "header": "tr|A0AAA9S5G0-1|A0AAA9S5G0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A2H PE=3 SV=1 CANONICAL=A0AAA9S5G0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0/entry#A0AAA9S5G0-1", "sequence": { "sequence": "METRNNVTEFVLLGLTQRNQGQKILFVLFLLIYIVTMVGTLLIVLTVVFSPTLDVPMYFFLGYLSFMDAVYATTVNPNTFTDLLYEKKTISFQACMIQLFTEHLFGGAEILLLVIMAYDRYVAICKPLHYVTIMNKRVCVLLLLLAWVGGLLHAIVNILFVYYLPFCGPNVIDHFICAMYPLLKLACTDTHSIAIIVVANDGIICVVLFMLLLMSYGAILHSLKNISQEGRRKALSICGSHITVVLLFFVPCIFLYVRPPSILPIDKSLAVFYTIITPMLNPLIYTLRNSEMQHAMGKLWIRKRT", "length": 305, "header": "tr|A0AAA9S5G0-1|A0AAA9S5G0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A2H PE=3 SV=1 CANONICAL=A0AAA9S5G0-1" }, "locus": { "chromosome": "15", "start_pos": 702872, "end_pos": 701958, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091652.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091652.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077395.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077395.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522410", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522410", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 285, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5L7-1", "uniprot_ac": "A0AAA9S5L7", "uniprot_id": "A0AAA9S5L7_BOVIN", "mass": { "chemical_mass": 54299.0, "monoisotopic_mass": 54299.0 }, "refseq": {}, "gene_names": [ { "name": "DSCC1", "type": "recommended", "evidence": [ { "id": "A0AAA9S5L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ] } ], "protein_names": [ { "name": "Sister chromatid cohesion protein DCC1", "type": "recommended", "evidence": [ { "id": "A0AAA9S5L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DSCC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7", "locus": { "chromosome": "14", "start_pos": 81263986, "end_pos": 81277197, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015338", "url": "https://www.ensembl.org/id/ENSBTAG00000015338" } ] } } ], "crossref": [ { "id": "A0AAA9S5L7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015338", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015338", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MTU0", "url": "https://www.orthodb.org/?gene=F1MTU0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13395", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13395", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13395:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13395:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09724", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09724", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-174411", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTU0", "url": "https://www.uniprot.org/uniprotkb/F1MTU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTU0-1", "url": "https://www.uniprot.org/uniprotkb/F1MTU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAKRVCQGPPAAEPTARRAGSPRETGRGAQRRGGAGPPSLPPPPGSRARLCRRPARPWPAPPARRGRASPGALFPRRFPRRGLVSVAPRPPAAMERTRAEVDATLQTAKLDAAELLPAAHCLRFGPAAAGDVCLLELEPALCGRLQAGRSLVIRGDKDEQAVLCSEDKTYDLKVADTSNMLLFIPGCKIPEQLKMEETHGNIIHTEIFGFSNNYWELRRCRPKLKKLKKLLMENTYEGPDSEKEKDSSHSKYTTEDLLDQIQASEEEIMTQLQVLNACEIGGYWRILEFDYEMKLLNHITQLVDSESWSFSKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYTEEGAVYFELSADKICRATAQMLLQNAVKFNLAEFQEVWQQSVPEGMTTRLDQLKGLALVDRQSRPEIIFLLKAEDLPEGDQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYARSSMQNGVKVYNSRRPIS", "length": 483, "header": "tr|A0AAA9S5L7-1|A0AAA9S5L7_BOVIN Isoform 1 of Sister chromatid cohesion protein DCC1 OS=Bos taurus OX=9913 GN=DSCC1 PE=3 SV=1 CANONICAL=A0AAA9S5L7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7/entry#A0AAA9S5L7-1", "sequence": { "sequence": "MRAKRVCQGPPAAEPTARRAGSPRETGRGAQRRGGAGPPSLPPPPGSRARLCRRPARPWPAPPARRGRASPGALFPRRFPRRGLVSVAPRPPAAMERTRAEVDATLQTAKLDAAELLPAAHCLRFGPAAAGDVCLLELEPALCGRLQAGRSLVIRGDKDEQAVLCSEDKTYDLKVADTSNMLLFIPGCKIPEQLKMEETHGNIIHTEIFGFSNNYWELRRCRPKLKKLKKLLMENTYEGPDSEKEKDSSHSKYTTEDLLDQIQASEEEIMTQLQVLNACEIGGYWRILEFDYEMKLLNHITQLVDSESWSFSKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYTEEGAVYFELSADKICRATAQMLLQNAVKFNLAEFQEVWQQSVPEGMTTRLDQLKGLALVDRQSRPEIIFLLKAEDLPEGDQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYARSSMQNGVKVYNSRRPIS", "length": 483, "header": "tr|A0AAA9S5L7-1|A0AAA9S5L7_BOVIN Isoform 1 of Sister chromatid cohesion protein DCC1 OS=Bos taurus OX=9913 GN=DSCC1 PE=3 SV=1 CANONICAL=A0AAA9S5L7-1" }, "locus": { "chromosome": "14", "start_pos": 81276884, "end_pos": 81264368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090394.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090394.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078573.1" } ] } }, { "isoform_ac": "F1MTU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7/entry#F1MTU0-1", "sequence": { "sequence": "MSRPARRRADGQESGVPAGNGARGAAEGRGRTAQSPPAPGVSGAPVPPPRPSLARPARPPRPRFSRRAFPAPFPASGARLCRPPAPGGHGEDPRRGGRDTADRQAGRGRAAARRALPALRARGRRRRVPAGAGARAVRAAAGRAQIFGFSNNYWELRRCRPKLKKLKKLLMENTYEGPDSEKEKDSSHSKYTTEDLLDQIQASEEEIMTQLQVLNACEIGGYWRILEFDYEMKLLNHITQLVDSESWSFSKVPLNTCLQELGPLEPEEMIEHCLKCYGKKYTEEGAVYFELSADKICRATAQMLLQNAVKFNLAEFQEVWQQSVPEGMTTRLDQLKGLALVDRQSRPEIIFLLKAEDLPEGDQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYARSSMQNGVKVYNSRRPIS", "length": 421, "header": "tr|F1MTU0-1|F1MTU0_BOVIN Computationally mapped isoform of Sister chromatid cohesion protein DCC1 OS=Bos taurus OX=9913 GN=DSCC1 PE=3 SV=4 CANONICAL=A0AAA9S5L7-1" }, "locus": { "chromosome": "14", "start_pos": 81276867, "end_pos": 81264368, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020389.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020389.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020389.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020389.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-174411", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "resource": "Reactome", "description": "Polymerase switching on the C-strand of the telomere" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" }, { "name": "Ctf18 RFC-like complex", "id": "GO:0031390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031390", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" }, { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" }, { "name": "maintenance of mitotic sister chromatid cohesion", "id": "GO:0034088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA clamp loader activity", "id": "GO:0003689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003689", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" }, { "name": "single-stranded DNA helicase activity", "id": "GO:0017116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5M1-1", "uniprot_ac": "A0AAA9S5M1", "uniprot_id": "A0AAA9S5M1_BOVIN", "mass": { "chemical_mass": 35957.0, "monoisotopic_mass": 35957.0 }, "refseq": {}, "gene_names": [ { "name": "BAG1", "type": "recommended", "evidence": [ { "id": "A0AAA9S5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ] } ], "protein_names": [ { "name": "BAG family molecular chaperone regulator 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BAG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1", "locus": { "chromosome": "8", "start_pos": 75021398, "end_pos": 75044152, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017845", "url": "https://www.ensembl.org/id/ENSBTAG00000017845" } ] } } ], "crossref": [ { "id": "A0AAA9S5M1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5M1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01812", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01812", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12329", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12329", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12329:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12329:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCHFLLQCMKVKSESEVTQSCPTPIDPMDCSPPGPSVHGIFQKSAVRSVTRGHAGSTRGAAACARRPRVKKKAQPRSARSEEVCRSEEMSRSEEVAPSEEVVPSEEVALSEEVAQSEEMAAAGLSVTVTHSNEKHDLQVTPQEGNSEPIVQDLAQVVEEATGVPLSFQKLIFKGKSLKEMEMPLSALGIQNGCRVMLIGKKNSPEEEAELKKLKDLEKSVEKIADQLEELNKDLAGIQQGFLAKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRMKRKGLVKRIQAFLAECDTVEQNICQETERLQSTNLALAD", "length": 326, "header": "tr|A0AAA9S5M1-1|A0AAA9S5M1_BOVIN Isoform 1 of BAG family molecular chaperone regulator 1 OS=Bos taurus OX=9913 GN=BAG1 PE=4 SV=1 CANONICAL=A0AAA9S5M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1/entry#A0AAA9S5M1-1", "sequence": { "sequence": "MGCHFLLQCMKVKSESEVTQSCPTPIDPMDCSPPGPSVHGIFQKSAVRSVTRGHAGSTRGAAACARRPRVKKKAQPRSARSEEVCRSEEMSRSEEVAPSEEVVPSEEVALSEEVAQSEEMAAAGLSVTVTHSNEKHDLQVTPQEGNSEPIVQDLAQVVEEATGVPLSFQKLIFKGKSLKEMEMPLSALGIQNGCRVMLIGKKNSPEEEAELKKLKDLEKSVEKIADQLEELNKDLAGIQQGFLAKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRMKRKGLVKRIQAFLAECDTVEQNICQETERLQSTNLALAD", "length": 326, "header": "tr|A0AAA9S5M1-1|A0AAA9S5M1_BOVIN Isoform 1 of BAG family molecular chaperone regulator 1 OS=Bos taurus OX=9913 GN=BAG1 PE=4 SV=1 CANONICAL=A0AAA9S5M1-1" }, "locus": { "chromosome": "8", "start_pos": 75044060, "end_pos": 75022314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079143.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079143.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 51, "start_aa": "Thr", "end_pos": 51, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr51", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "pmid": "" }, { "name": "adenyl-nucleotide exchange factor activity", "id": "GO:0000774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" }, { "id": "PS51035", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAG", "eco_id": "ECO_0000259", "start_pos": 227, "end_pos": 307, "start_aa": "Gln", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M1" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 205, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 51 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5M6-1", "uniprot_ac": "A0AAA9S5M6", "uniprot_id": "A0AAA9S5M6_BOVIN", "mass": { "chemical_mass": 52481.0, "monoisotopic_mass": 52481.0 }, "refseq": { "ac": "XP_005215764", "name": "solute carrier family 7 member 13 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215764" }, "gene_names": [ { "name": "LOC518422", "type": "recommended", "evidence": [ { "id": "A0AAA9S5M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ] }, { "name": "LOC518422", "type": "synonym", "evidence": [ { "id": "XP_005215764", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215764" } ] } ], "protein_names": [ { "name": "Solute carrier family 7 member 13", "type": "recommended", "evidence": [ { "id": "A0AAA9S5M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 7 member 13 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005215764", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215764" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC518422", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S5M6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518422", "url": "https://www.ncbi.nlm.nih.gov/gene/518422", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MUB4", "url": "https://www.orthodb.org/?gene=F1MUB4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11785", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11785:SF348", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785:SF348", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005215764", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215764", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUB4", "url": "https://www.uniprot.org/uniprotkb/F1MUB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUB4-1", "url": "https://www.uniprot.org/uniprotkb/F1MUB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLLRAIGFFRGNILILSATIGAGIFVSPKGVLKYSSLNVAVSLSIWAACAVLTLISALSHAELGTTFPISGAQYYFLKRSLGSSVAFLNLWIKLFTHPLRLATESLLLSTYTIQPFYAGCPAPELPKRCLALAALWSLGLLNARGVQTVAWLQTVSTLAKMTVLCFICFTGIVLLGMGERENVARFENALDAELPDVSQIAEAFLQGLFAYSGTSILNSMAGEIKNPGKNIPKSLITGIPMVAVVYLLANVSYLAVLTPKEIVSADAVALTWTDKIIPSMQWVISFGISTSVFSTMCCTVLSASRMIYRASQEGQLPFIFSMLNKHSCPTTAVSQLIILTSIVIITSDLINLIRYSGLALWFLRGLHMIGLLKLRYQEPNLPRPYKVPLPFIFGSIAISLFLILTPLIKTPKMEHVYGLIFIFSGLLCYWIHVHLNQHSVSFVKVTCYLQLLFNVSPPEDHNEGISTEKSDLKVIFL", "length": 478, "header": "tr|A0AAA9S5M6-1|A0AAA9S5M6_BOVIN Isoform 1 of Solute carrier family 7 member 13 OS=Bos taurus OX=9913 GN=LOC518422 PE=3 SV=1 CANONICAL=A0AAA9S5M6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6/entry#A0AAA9S5M6-1", "sequence": { "sequence": "MQLLRAIGFFRGNILILSATIGAGIFVSPKGVLKYSSLNVAVSLSIWAACAVLTLISALSHAELGTTFPISGAQYYFLKRSLGSSVAFLNLWIKLFTHPLRLATESLLLSTYTIQPFYAGCPAPELPKRCLALAALWSLGLLNARGVQTVAWLQTVSTLAKMTVLCFICFTGIVLLGMGERENVARFENALDAELPDVSQIAEAFLQGLFAYSGTSILNSMAGEIKNPGKNIPKSLITGIPMVAVVYLLANVSYLAVLTPKEIVSADAVALTWTDKIIPSMQWVISFGISTSVFSTMCCTVLSASRMIYRASQEGQLPFIFSMLNKHSCPTTAVSQLIILTSIVIITSDLINLIRYSGLALWFLRGLHMIGLLKLRYQEPNLPRPYKVPLPFIFGSIAISLFLILTPLIKTPKMEHVYGLIFIFSGLLCYWIHVHLNQHSVSFVKVTCYLQLLFNVSPPEDHNEGISTEKSDLKVIFL", "length": 478, "header": "tr|A0AAA9S5M6-1|A0AAA9S5M6_BOVIN Isoform 1 of Solute carrier family 7 member 13 OS=Bos taurus OX=9913 GN=LOC518422 PE=3 SV=1 CANONICAL=A0AAA9S5M6-1" }, "locus": { "chromosome": "14", "start_pos": 77515623, "end_pos": 77500473, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134825.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134825.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079148.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079148.1" } ] } }, { "isoform_ac": "F1MUB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6/entry#F1MUB4-1", "sequence": { "sequence": "DNPDSHKSMQLLRAIGFFRGNILILSATIGAGIFVSPKGVLKYSSLNVAVSLSIWAACAVLTLISALSHAELGTTFPISGAQYYFLKRSLGSSVAFLNLWIKLFTHPLRLATESLLLSTYTIQPFYAGCPAPELPKRCLALAALWSLGLLNARGVQTVAWLQTVSTLAKMTVLCFICFTGIVLLGMGERENVARFENALDAELPDVSQIAEAFLQGLFAYSGTSILNSMAGEIKNPGKNIPKSLITGIPMVAVVYLLANVSYLAVLTPKEIVSADAVALTWTDKIIPSMQWVISFGISTSVFSTMCCTVLSASRMIYRASQEGQLPFIFSMLNKHSCPTTAVSQLIILTSIVIITSDLINLIRYSGLALWFLRGLHMIGLLKLRYQEPNLPRPYKVPLPFIFGSIAISLFLILTPLIKTPKMEHVYGLIFIFSGLLCYWIHVHLNQHSVSFVKVTCYLQLLFNVSPPEDHNEGISTEKSDLKVIFL", "length": 486, "header": "tr|F1MUB4-1|F1MUB4_BOVIN Computationally mapped isoform of Solute carrier family 7 member 13 OS=Bos taurus OX=9913 GN=LOC518422 PE=3 SV=3 CANONICAL=A0AAA9S5M6-1" }, "locus": { "chromosome": "14", "start_pos": 77516206, "end_pos": 77500473, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056811.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056811.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051535.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051535.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ], "pmid": "" }, { "name": "L-amino acid transmembrane transporter activity", "id": "GO:0015179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transmembrane transport", "id": "GO:0003333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 455, "end_pos": 457 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5P6-1", "uniprot_ac": "A0AAA9S5P6", "uniprot_id": "A0AAA9S5P6_BOVIN", "mass": { "chemical_mass": 27258.0, "monoisotopic_mass": 27258.0 }, "refseq": { "ac": "XP_002690159", "name": "general transcription factor 3C polypeptide 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690159" }, "gene_names": [ { "name": "GTF3C6", "type": "recommended", "evidence": [ { "id": "A0AAA9S5P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ] }, { "name": "GTF3C6", "type": "synonym", "evidence": [ { "id": "XP_002690159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690159" } ] } ], "protein_names": [ { "name": "General transcription factor 3C polypeptide 6", "type": "recommended", "evidence": [ { "id": "A0AAA9S5P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6/entry#names_and_taxonomy" } ] }, { "name": "Transcription factor IIIC 35 kDa subunit", "type": "synonym", "evidence": [ { "id": "A0AAA9S5P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6/entry#names_and_taxonomy" } ] }, { "name": "Transcription factor IIIC subunit 6", "type": "synonym", "evidence": [ { "id": "A0AAA9S5P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6/entry#names_and_taxonomy" } ] }, { "name": "general transcription factor 3C polypeptide 6", "type": "synonym", "evidence": [ { "id": "XP_002690159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690159" } ] } ], "function": [ { "annotation": "Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6#function" }, { "database": "UniProtKB", "id": "ARBA00057927", "url": "https://www.uniprot.org/uniprotkb/ARBA00057927#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF3C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6", "locus": { "chromosome": "9", "start_pos": 39366942, "end_pos": 39377477, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000067009", "url": "https://www.ensembl.org/id/ENSBTAG00000067009" } ] } } ], "crossref": [ { "id": "A0AAA9S5P6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "518472", "url": "https://www.ncbi.nlm.nih.gov/gene/518472", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518472", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518472", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR21860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21860:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21860:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10419", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10419", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690159", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690159", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPAGGAHGSLAAQRSGGMAAAAKEPSWVDWDEEEEEEEETEQLVMVELSGILDSDLLSKCENKCKILGIDTERPILQVDSYVFAGEYEDTVGTCVIFEENVEYVDAEGSNKTVLKYKCHTMKKLSMTRTLLTEKKEGEENIGGVEWLQIKENDFSYRPNMICNFLHQHEEDEAVAPDPDKSLELEEHETQMKDNSNLSFEQEKPPNLEIEDSGPLIDIPSFETEGSVFMDTQETAIEITPR", "length": 243, "header": "tr|A0AAA9S5P6-1|A0AAA9S5P6_BOVIN Isoform 1 of General transcription factor 3C polypeptide 6 OS=Bos taurus OX=9913 GN=GTF3C6 PE=3 SV=1 CANONICAL=A0AAA9S5P6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6/entry#A0AAA9S5P6-1", "sequence": { "sequence": "MAAPAGGAHGSLAAQRSGGMAAAAKEPSWVDWDEEEEEEEETEQLVMVELSGILDSDLLSKCENKCKILGIDTERPILQVDSYVFAGEYEDTVGTCVIFEENVEYVDAEGSNKTVLKYKCHTMKKLSMTRTLLTEKKEGEENIGGVEWLQIKENDFSYRPNMICNFLHQHEEDEAVAPDPDKSLELEEHETQMKDNSNLSFEQEKPPNLEIEDSGPLIDIPSFETEGSVFMDTQETAIEITPR", "length": 243, "header": "tr|A0AAA9S5P6-1|A0AAA9S5P6_BOVIN Isoform 1 of General transcription factor 3C polypeptide 6 OS=Bos taurus OX=9913 GN=GTF3C6 PE=3 SV=1 CANONICAL=A0AAA9S5P6-1" }, "locus": { "chromosome": "9", "start_pos": 39377278, "end_pos": 39367083, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107878.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107878.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080533.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518472", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518472", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "transcription factor TFIIIC complex", "id": "GO:0000127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000127", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ], "pmid": "" }, { "name": "RNA polymerase III general transcription initiation factor activity", "id": "GO:0000995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000995", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P6" }, { "id": "PF10419", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10419" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transcription factor TFIIIC triple barrel", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 133, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5P8-1", "uniprot_ac": "A0AAA9S5P8", "uniprot_id": "A0AAA9S5P8_BOVIN", "mass": { "chemical_mass": 58741.0, "monoisotopic_mass": 58741.0 }, "refseq": {}, "gene_names": [ { "name": "LOC132342142", "type": "recommended", "evidence": [ { "id": "A0AAA9S5P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8" } ] } ], "protein_names": [ { "name": "Submaxillary mucin-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S5P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132342142", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8", "locus": {} } ], "crossref": [ { "id": "A0AAA9S5P8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5P8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47246:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47246:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00007", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00007", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKASQFSHIAIIFPDSAGEATTLIVSNSTSGTGLRPEDNTAVAGGQATGRVTGTTKVIPGTTVAPGSSNTESTTSLGESRTRIGRITGATTGTSERSSPGSKTGNTGAISGTTVAPRSSNTGATTSLGSGETSQGGIKIVTMGVTTGTTIAPGSSNTKATTPTEVRTTTEVRTATETTTSRHSSDATGSGIQTGITGTGSGTTSSPGGFNAEATTFKEHVRTTETRILSGTTRGASGTTVIPESSNTGTSTGVGRQTSTAVVSGRVTGVSESSSPGTSKEASETTTGPGISTTGSTSKSNRITTSSRIPYPETTVVATGEQETETKTGCTTSLPPPPACYGPLGEKKSPGDIWTANCHKCTCTDAETVDCKLKECPSPPTCKPEERLVKFKDNDTCCEIAYCEPRTCLFNNNDYEVGASFADPNNPCISYSCHNTGFVAVVQDCPKQTWCAEEDRVYDSTKCCYTCKPYCRSSSVNVTVNYNGCKKKVEMARCAGECKKTIKYDYDIFQLKNSCLCCQEENYEYREIDLDCPDGGTIPYRYRHIITCSCLDICQQSMTSTVS", "length": 562, "header": "tr|A0AAA9S5P8-1|A0AAA9S5P8_BOVIN Isoform 1 of Submaxillary mucin-like protein OS=Bos taurus OX=9913 GN=LOC132342142 PE=4 SV=1 CANONICAL=A0AAA9S5P8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8/entry#A0AAA9S5P8-1", "sequence": { "sequence": "MKASQFSHIAIIFPDSAGEATTLIVSNSTSGTGLRPEDNTAVAGGQATGRVTGTTKVIPGTTVAPGSSNTESTTSLGESRTRIGRITGATTGTSERSSPGSKTGNTGAISGTTVAPRSSNTGATTSLGSGETSQGGIKIVTMGVTTGTTIAPGSSNTKATTPTEVRTTTEVRTATETTTSRHSSDATGSGIQTGITGTGSGTTSSPGGFNAEATTFKEHVRTTETRILSGTTRGASGTTVIPESSNTGTSTGVGRQTSTAVVSGRVTGVSESSSPGTSKEASETTTGPGISTTGSTSKSNRITTSSRIPYPETTVVATGEQETETKTGCTTSLPPPPACYGPLGEKKSPGDIWTANCHKCTCTDAETVDCKLKECPSPPTCKPEERLVKFKDNDTCCEIAYCEPRTCLFNNNDYEVGASFADPNNPCISYSCHNTGFVAVVQDCPKQTWCAEEDRVYDSTKCCYTCKPYCRSSSVNVTVNYNGCKKKVEMARCAGECKKTIKYDYDIFQLKNSCLCCQEENYEYREIDLDCPDGGTIPYRYRHIITCSCLDICQQSMTSTVS", "length": 562, "header": "tr|A0AAA9S5P8-1|A0AAA9S5P8_BOVIN Isoform 1 of Submaxillary mucin-like protein OS=Bos taurus OX=9913 GN=LOC132342142 PE=4 SV=1 CANONICAL=A0AAA9S5P8-1" }, "locus": { "chromosome": "5", "start_pos": 40357455, "end_pos": 40326849, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091988.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091988.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078615.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078615.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8" }, { "id": "PS01225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTCK", "eco_id": "ECO_0000259", "start_pos": 470, "end_pos": 554, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P8" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 337, "end_pos": 403, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 27, "end_pos": 29 }, { "start_pos": 393, "end_pos": 395 }, { "start_pos": 476, "end_pos": 478 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5R6-1", "uniprot_ac": "A0AAA9S5R6", "uniprot_id": "A0AAA9S5R6_BOVIN", "mass": { "chemical_mass": 64529.0, "monoisotopic_mass": 64529.0 }, "refseq": { "ac": "XP_024840568", "name": "acyl-CoA synthetase medium-chain family member 2B isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840568" }, "gene_names": [ { "name": "ACSM2B", "type": "recommended", "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ] }, { "name": "ACSM2A", "type": "synonym", "evidence": [ { "id": "XP_024840568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840568" } ] }, { "name": "ACSM2B", "type": "synonym", "evidence": [ { "id": "XP_024840568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840568" } ] } ], "protein_names": [ { "name": "medium-chain acyl-CoA ligase", "type": "recommended", "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6/entry#names_and_taxonomy" } ] }, { "name": "6.2.1.2", "type": "synonym", "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6/entry#names_and_taxonomy" } ] }, { "name": "acyl-CoA synthetase medium-chain family member 2B isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024840568", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840568" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACSM2B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6", "locus": { "chromosome": "25", "start_pos": 18234033, "end_pos": 18162095, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019423", "url": "https://www.ensembl.org/id/ENSBTAG00000019423" } ] } } ], "crossref": [ { "id": "A0AAA9S5R6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5R6", "database": "AlphaFoldDB", "categories": [] }, { "id": "512227", "url": "https://www.ncbi.nlm.nih.gov/gene/512227", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43605", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43605", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43605:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43605:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840568", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840568", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "48340", "url": "https://www.rhea-db.org/rhea/48340", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S666", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S666", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S666-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S666-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHWGRQLQALCILWRSQMSNHTIRIHTRQLASLQWGHQEVPAKFNFATDVIDHWAGMEKAGKRPPGPALWWVNGNGDEVMWNFSQLSELSQQTANVFAGPCGLQRGDRVTVVLPRVPEWWLVILGCMRAGLVFMPGTIQMKAKDILYRLQVSKAKAIVAGDEVAEIVDTVAPECPSLKTKLLVSEKKRDGWLDFKTLLWKASTTHCFVETGSQEAAAIYFTSGTSGLPKMAEHSHSSLGIKAKMDAGKWTDLQASDIIWPISDTAWIVNILGSLLEPWTSGACTFIHLLPKFDPVIILKVLSSYPINYMVGAPIVYRMLLLQDLSSYKFPHLKCCFSGGETLLPDTLEKWKAQTGLDILEFYGQTETGLTCRVSKTMKIKPGYLGTAIPHYDVQVIDDKGNVLPPGTEGDVGIRVKPIRPIGIFSGYVDNLEKTEANIRGDFWVLGDRAIKDQEGYFRFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVVSSPDPIRGEVVKAFVVLAPHFLSRDPDELTKELQQHVKLVTAPYKYPRKIEFVLDLPKTNTGKIQRSKLRDKEWKKSEQVGV", "length": 577, "header": "tr|A0AAA9S5R6-1|A0AAA9S5R6_BOVIN Isoform 1 of medium-chain acyl-CoA ligase OS=Bos taurus OX=9913 GN=ACSM2B PE=1 SV=1 CANONICAL=A0AAA9S5R6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6/entry#A0AAA9S5R6-1", "sequence": { "sequence": "MHWGRQLQALCILWRSQMSNHTIRIHTRQLASLQWGHQEVPAKFNFATDVIDHWAGMEKAGKRPPGPALWWVNGNGDEVMWNFSQLSELSQQTANVFAGPCGLQRGDRVTVVLPRVPEWWLVILGCMRAGLVFMPGTIQMKAKDILYRLQVSKAKAIVAGDEVAEIVDTVAPECPSLKTKLLVSEKKRDGWLDFKTLLWKASTTHCFVETGSQEAAAIYFTSGTSGLPKMAEHSHSSLGIKAKMDAGKWTDLQASDIIWPISDTAWIVNILGSLLEPWTSGACTFIHLLPKFDPVIILKVLSSYPINYMVGAPIVYRMLLLQDLSSYKFPHLKCCFSGGETLLPDTLEKWKAQTGLDILEFYGQTETGLTCRVSKTMKIKPGYLGTAIPHYDVQVIDDKGNVLPPGTEGDVGIRVKPIRPIGIFSGYVDNLEKTEANIRGDFWVLGDRAIKDQEGYFRFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVVSSPDPIRGEVVKAFVVLAPHFLSRDPDELTKELQQHVKLVTAPYKYPRKIEFVLDLPKTNTGKIQRSKLRDKEWKKSEQVGV", "length": 577, "header": "tr|A0AAA9S5R6-1|A0AAA9S5R6_BOVIN Isoform 1 of medium-chain acyl-CoA ligase OS=Bos taurus OX=9913 GN=ACSM2B PE=1 SV=1 CANONICAL=A0AAA9S5R6-1" }, "locus": { "chromosome": "25", "start_pos": 18209976, "end_pos": 18163621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106771.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106771.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078637.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078637.1" } ] } }, { "isoform_ac": "A0AAA9S666-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6/entry#A0AAA9S666-1", "sequence": { "sequence": "MHWGRQLQALCILWRSQMSNHTIRIHTRQLASLQWGHQEVPAKFNFATDVIDHWAGMEKAGKRPPGPALWWVNGNGDEVMWNFSQLSELSQQTANVFAGPCGLQRGDRVTVVLPRVPEWWLVILGCMRAGLVFMPGTIQMKAKDILYRLQVSKAKAIVAGDEVAEIVDTVAPECPSLKTKLLVSEKKRDGWLDFKTLLWKASTTHCFVETGSQEAAAIYFTSGTSGLPKMAEHSHSSLGIKAKMDAGKWTDLQASDIIWPISDTAWIVNILGSLLEPWTSGACTFIHLLPKFDPVIILKVLSSYPINYMVGAPIVYRMLLLQDLSSYKFPHLKCCFSGGETLLPDTLEKWKAQTGLDILEFYGQTETGLTCRVSKTMKIKPGYLGTAIPHYDVQVIDDKGNVLPPGTEGDVGIRVKPIRPIGIFSGYVDNLEKTEANIRGDFWVLGDRAIKDQEGYFRFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVVSSPDPIRGEVVKAFVVLAPHFLSRDPDELTKELQQHVKLVTAPYKYPRKIEFVLDLPKTNTGKIQRSKLRDKEWKKSEQRELNF", "length": 579, "header": "tr|A0AAA9S666-1|A0AAA9S666_BOVIN Computationally mapped isoform of medium-chain acyl-CoA ligase OS=Bos taurus OX=9913 GN=ACSM2B PE=1 SV=1 CANONICAL=A0AAA9S5R6-1" }, "locus": { "chromosome": "25", "start_pos": 18233962, "end_pos": 18163621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115464.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115464.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080704.1" } ] } }, { "isoform_ac": "A0AAA9T6J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6/entry#A0AAA9T6J3-1", "sequence": { "sequence": "MHWGRQLQALCILWRSQMSNHTIRIHTRQLASLQWGHQEVPAKFNFATDVIDHWAGMEKAGKRPPGPALWWVNGNGDEVMWNFSQLSELSQQTANVFAGPCGLQRGDRVTVVLPRVPEWWLVILGCMRAGLVFMPGTIQMKAKDILYRLQVSKAKAIVAGDEVAEIVDTVAPECPSLKTKLLVSEKKRDGWLDFKTLLWKASTTHCFVETGSQEAAAIYFTSGTSGLPKMAEHSHSSLGIKAKMDAGKWTDLQASDIIWPISDTAWIVNILGSLLEPWTSGACTFIHLLPKFDPVIILKVLSSYPINYMVGAPIVYRMLLLQDLSSYKFPHLKCCFSGGETLLPDTLEKWKAQTGLDILEFYGQTETGLTCRVSKTMKIKPGYLGTAIPHYDVQVIDDKGNVLPPGTEGDVGIRVKPIRPIGIFSGYVDNLEKTEANIRGDFWVLGDRAIKDQEGYFRFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVVSSPDPIRGEVVKAFVVLAPHFLSRDPDELTKELQQHVKLVTAPYKYPRKVDSSPAEPPGKPKNTEVGSLSILQGNFQTQELNQGLLYCRQILYQLSYPGSP", "length": 596, "header": "tr|A0AAA9T6J3-1|A0AAA9T6J3_BOVIN Computationally mapped isoform of medium-chain acyl-CoA ligase OS=Bos taurus OX=9913 GN=ACSM2B PE=1 SV=1 CANONICAL=A0AAA9S5R6-1" }, "locus": { "chromosome": "25", "start_pos": 18201867, "end_pos": 18163621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106916.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106916.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091397.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ], "pmid": "" }, { "name": "medium-chain fatty acid-CoA ligase activity", "id": "GO:0031956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031956", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48340", "name": "", "equation": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5R6-1", "E1BHV3-1", "G3N2S1-1", "F1MES1-1", "F1MPP7-1", "Q9BEA2-1", "Q17QJ1-1" ], "evidence": [ { "id": "48340", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48340" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S5R6", "gene_name": "ACSM2B", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" } ] } ] }, { "uniprot_ac": "E1BHV3", "gene_name": "ACSM5", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BHV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHV3" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "E1BHV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHV3" } ] } ] }, { "uniprot_ac": "F1MES1", "gene_name": "ACSM3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MES1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "F1MES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MES1" } ] } ] }, { "uniprot_ac": "F1MPP7", "gene_name": "ACSM1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MPP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPP7" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "F1MPP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPP7" } ] } ] }, { "uniprot_ac": "G3N2S1", "gene_name": "ACSM4", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "G3N2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2S1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "G3N2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2S1" } ] } ] }, { "uniprot_ac": "Q17QJ1", "gene_name": "ACSF2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q17QJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q17QJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ1" } ] } ] }, { "uniprot_ac": "Q9BEA2", "gene_name": "ACSM1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9BEA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BEA2" } ] }, { "ec_number": "6.2.1.25", "activity": "benzoate + ATP + CoA = benzoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9BEA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BEA2" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q9BEA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BEA2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" }, { "id": "PF13193", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AMP-binding enzyme C-terminal", "eco_id": "ECO_0000259", "start_pos": 478, "end_pos": 558, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R6" }, { "id": "PF00501", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AMP-dependent synthetase/ligase", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 427, "start_aa": "Lys", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.2.1.2", "ec_name": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "6.2.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2" }, { "id": "6.2.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 20, "end_pos": 22 }, { "start_pos": 468, "end_pos": 470 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5R8-1", "uniprot_ac": "A0AAA9S5R8", "uniprot_id": "A0AAA9S5R8_BOVIN", "mass": { "chemical_mass": 14883.0, "monoisotopic_mass": 14883.0 }, "refseq": {}, "gene_names": [ { "name": "TRBV30", "type": "recommended", "evidence": [ { "id": "A0AAA9S5R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8" } ] } ], "protein_names": [ { "name": "T cell receptor beta variable 30", "type": "synonym", "evidence": [ { "id": "A0AAA9S5R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRBV30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8", "locus": { "chromosome": "4", "start_pos": 106120900, "end_pos": 106121809, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065350", "url": "https://www.ensembl.org/id/ENSBTAG00000065350" } ] } } ], "crossref": [ { "id": "A0AAA9S5R8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5R8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HQWPATK", "url": "https://omabrowser.org/oma/group/HQWPATK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23268:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23268:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPAGVRTQTIHQWPSTRVQPAGSPLSLECTVKGTSNPTLYWYRQEAGGSLQQLFYSVSAGQIEPREFQNFKASRPQDGQFTLSSKKLQLNNSGFYFCAWSLTLRWVGQTSVQKPHPVPRPPHPLQQPSLRD", "length": 132, "header": "tr|A0AAA9S5R8-1|A0AAA9S5R8_BOVIN Isoform 1 of T cell receptor beta variable 30 OS=Bos taurus OX=9913 GN=TRBV30 PE=4 SV=2 CANONICAL=A0AAA9S5R8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8/entry#A0AAA9S5R8-1", "sequence": { "sequence": "MLPAGVRTQTIHQWPSTRVQPAGSPLSLECTVKGTSNPTLYWYRQEAGGSLQQLFYSVSAGQIEPREFQNFKASRPQDGQFTLSSKKLQLNNSGFYFCAWSLTLRWVGQTSVQKPHPVPRPPHPLQQPSLRD", "length": 132, "header": "tr|A0AAA9S5R8-1|A0AAA9S5R8_BOVIN Isoform 1 of T cell receptor beta variable 30 OS=Bos taurus OX=9913 GN=TRBV30 PE=4 SV=2 CANONICAL=A0AAA9S5R8-1" }, "locus": { "chromosome": "4", "start_pos": 106121401, "end_pos": 106121006, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093233.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093233.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077505.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077505.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0K0K1B3-1", "protein_name": "T cell receptor beta variable 30", "gene_name": "TRBV30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLCSLLALLLGTFFGVRSQTIHQWPATLVQPVGSPLSLECTVEGTSNPNLYWYRQAAGRGLQLLFYSVGIGQISSEVPQNLSASRPQDRQFILSSKKLLLSDSGFYLCAWS", "length": 111 }, "evidence": [ { "id": "A0AAA9S5R8", "url": "https://omabrowser.org/oma/group/A0AAA9S5R8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5R8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 98, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S2L4-1", "uniprot_ac": "A0AAA9S2L4", "uniprot_id": "A0AAA9S2L4_BOVIN", "mass": { "chemical_mass": 10595.0, "monoisotopic_mass": 10595.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "C-C motif chemokine", "type": "recommended", "evidence": [ { "id": "A0AAA9S2L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S2L4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S2L4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00272", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00272", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12015:SF180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12015:SF180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S2L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIPGASLAVLLLTAALSAHTCSATCEAFSTNTPTDCCFSFVSRQIPRKLVDDYYETSSQCSKPGIIFKTKRGRQVCADPSEDWVQEYIIDLELNP", "length": 96, "header": "tr|A0AAA9S2L4-1|A0AAA9S2L4_BOVIN Isoform 1 of C-C motif chemokine OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9S2L4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4/entry#A0AAA9S2L4-1", "sequence": { "sequence": "MEIPGASLAVLLLTAALSAHTCSATCEAFSTNTPTDCCFSFVSRQIPRKLVDDYYETSSQCSKPGIIFKTKRGRQVCADPSEDWVQEYIIDLELNP", "length": 96, "header": "tr|A0AAA9S2L4-1|A0AAA9S2L4_BOVIN Isoform 1 of C-C motif chemokine OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9S2L4-1" }, "locus": { "chromosome": "19", "start_pos": 14279284, "end_pos": 14278192, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088722.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088722.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080161.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080161.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S2L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2L4" }, { "id": "SM00199", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chemokine interleukin-8-like", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 92, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S3X1-1", "uniprot_ac": "A0AAA9S3X1", "uniprot_id": "A0AAA9S3X1_BOVIN", "mass": { "chemical_mass": 63176.0, "monoisotopic_mass": 63176.0 }, "refseq": {}, "gene_names": [ { "name": "SYN3", "type": "recommended", "evidence": [ { "id": "A0AAA9S3X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ] } ], "protein_names": [ { "name": "Synapsin III", "type": "synonym", "evidence": [ { "id": "A0AAA9S3X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1", "locus": { "chromosome": "5", "start_pos": 71115794, "end_pos": 71612652, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020636", "url": "https://www.ensembl.org/id/ENSBTAG00000020636" } ] } } ], "crossref": [ { "id": "A0AAA9S3X1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S3X1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050644", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050644", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10841", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10841", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10841:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10841:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02078", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02078", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02750", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02750", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M2T3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2T3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8V8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8V8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1P1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD", "length": 579, "header": "tr|A0AAA9S3X1-1|A0AAA9S3X1_BOVIN Isoform 1 of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=1 CANONICAL=A0AAA9S3X1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0A3Q1M2T3-1", "sequence": { "sequence": "MNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLNPTAEDCCCC", "length": 544, "header": "tr|A0A3Q1M2T3-1|A0AAA9S3X1_BOVIN Computationally mapped isoform of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=2 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71577639, "end_pos": 71117579, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085064.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085064.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064139.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064139.2" } ] } }, { "isoform_ac": "A0A3Q1M8V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0A3Q1M8V8-1", "sequence": { "sequence": "MDGDSSNRKLVKKKTAVADLCGTPLALLAQDPTTPCPWQPVFWASPRQPEWEQAISSITAMNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD", "length": 638, "header": "tr|A0A3Q1M8V8-1|A0A3Q1M8V8_BOVIN Computationally mapped isoform of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=2 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71611257, "end_pos": 71126776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068830.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068830.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066903.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066903.2" } ] } }, { "isoform_ac": "A0AAA9S3X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0AAA9S3X1-1", "sequence": { "sequence": "MNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD", "length": 579, "header": "tr|A0AAA9S3X1-1|A0AAA9S3X1_BOVIN Isoform 1 of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=1 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71577639, "end_pos": 71126776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134356.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134356.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076811.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076811.1" } ] } }, { "isoform_ac": "A0AAA9SCB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0AAA9SCB0-1", "sequence": { "sequence": "MNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLNMPSWKSPRKSRRYKHLHRS", "length": 554, "header": "tr|A0AAA9SCB0-1|A0AAA9SCB0_BOVIN Computationally mapped isoform of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=1 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71577639, "end_pos": 71116004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083021.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083021.1" } ] } }, { "isoform_ac": "A0AAA9T1P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0AAA9T1P1-1", "sequence": { "sequence": "MNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLKTDS", "length": 538, "header": "tr|A0AAA9T1P1-1|A0AAA9T1P1_BOVIN Computationally mapped isoform of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=1 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71577639, "end_pos": 71129214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089097.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089097.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092706.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092706.1" } ] } }, { "isoform_ac": "A0AAA9TRP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0AAA9TRP7-1", "sequence": { "sequence": "MNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLKTST", "length": 538, "header": "tr|A0AAA9TRP7-1|A0AAA9TRP7_BOVIN Computationally mapped isoform of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=1 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71577639, "end_pos": 71120563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135702.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135702.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099992.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099992.1" } ] } }, { "isoform_ac": "A0AAA9TZR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1/entry#A0AAA9TZR9-1", "sequence": { "sequence": "MWKIQVKKKTAVADLCGTPLALLAQDPTTPCPWQPVFWASPRQPEWEQAISSITAMNFLRRRLSDSSFVANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSFSSAMKQTSQAPSGLMEPPGPSTPVVQRPRILLVIDDAHTDWAKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVMRNGTKVVRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPHFPVVVKLGHAHAGMGKIKVENQHDYQDVTSMVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVISKMSQLLMPGGTVPSPLRPWAPQTKPAKSPGQAQLGPPLGQPQPRPPTQGGPRPAQSPQPPRSGSPSQQRLSPQGQQPLSPQSGSPQQRSPGSPQLSRASGGSSPNQAPKSSAPLTSQPRPPVQGRSASQQGEEAKKPASPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD", "length": 633, "header": "tr|A0AAA9TZR9-1|A0AAA9TZR9_BOVIN Computationally mapped isoform of Synapsin III OS=Bos taurus OX=9913 GN=SYN3 PE=3 SV=1 CANONICAL=A0AAA9S3X1-1" }, "locus": { "chromosome": "5", "start_pos": 71578365, "end_pos": 71126776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103080.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103080.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neurotransmitter secretion", "id": "GO:0007269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007269", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" }, { "name": "synaptic vesicle clustering", "id": "GO:0097091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" }, { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S3X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" }, { "id": "PF02750", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02750" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Synapsin ATP-binding", "eco_id": "ECO_0000259", "start_pos": 193, "end_pos": 395, "start_aa": "Asn", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S3X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X1" }, { "id": "PF02078", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02078" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Synapsin pre-ATP-grasp", "eco_id": "ECO_0000259", "start_pos": 89, "end_pos": 191, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 536, "end_pos": 538 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S3S6-1", "uniprot_ac": "A0AAA9S3S6", "uniprot_id": "A0AAA9S3S6_BOVIN", "mass": { "chemical_mass": 33548.0, "monoisotopic_mass": 33548.0 }, "refseq": {}, "gene_names": [ { "name": "VTA1", "type": "recommended", "evidence": [ { "id": "A0AAA9S3S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ] } ], "protein_names": [ { "name": "Vesicle trafficking 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S3S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VTA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6", "locus": { "chromosome": "9", "start_pos": 79700323, "end_pos": 79629610, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005851", "url": "https://www.ensembl.org/id/ENSBTAG00000005851" } ] } } ], "crossref": [ { "id": "A0AAA9S3S6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S3S6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005851", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005851", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR023175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506430", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506430", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AYWCEYH", "url": "https://omabrowser.org/oma/group/AYWCEYH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0D7", "url": "https://www.orthodb.org/?gene=A0A3Q1M0D7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N318", "url": "https://www.orthodb.org/?gene=F1N318", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46009", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46009:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46009:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M0D7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0D7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N318", "url": "https://www.uniprot.org/uniprotkb/F1N318", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N318-1", "url": "https://www.uniprot.org/uniprotkb/F1N318-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNVDVEENEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGDASGIKPTCQCRRHKRRRFDPSVQKIPWRRKWQPTPVFLSGESHGQTSLAVYSPWSHKESDMTEAA", "length": 299, "header": "tr|A0AAA9S3S6-1|A0AAA9S3S6_BOVIN Isoform 1 of Vesicle trafficking 1 OS=Bos taurus OX=9913 GN=VTA1 PE=4 SV=2 CANONICAL=A0AAA9S3S6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6/entry#A0A3Q1M0D7-1", "sequence": { "sequence": "MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDVEENEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE", "length": 279, "header": "tr|A0A3Q1M0D7-1|A0A3Q1M0D7_BOVIN Computationally mapped isoform of Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus OX=9913 GN=VTA1 PE=3 SV=2 CANONICAL=A0AAA9S3S6-1" }, "locus": { "chromosome": "9", "start_pos": 79699148, "end_pos": 79629665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069828.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069828.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063101.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063101.2" } ] } }, { "isoform_ac": "A0AAA9S3S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6/entry#A0AAA9S3S6-1", "sequence": { "sequence": "MAALATLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSRLMDQLEALKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNVDVEENEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGDASGIKPTCQCRRHKRRRFDPSVQKIPWRRKWQPTPVFLSGESHGQTSLAVYSPWSHKESDMTEAA", "length": 299, "header": "tr|A0AAA9S3S6-1|A0AAA9S3S6_BOVIN Isoform 1 of Vesicle trafficking 1 OS=Bos taurus OX=9913 GN=VTA1 PE=4 SV=2 CANONICAL=A0AAA9S3S6-1" }, "locus": { "chromosome": "9", "start_pos": 79689725, "end_pos": 79629665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119548.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119548.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076759.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076759.2" } ] } }, { "isoform_ac": "F1N318-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6/entry#F1N318-1", "sequence": { "sequence": "MTSETLWWHITLKKQLGDNEAITQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDVEENEDAGATSLPTQPLQPSSSTYDPSNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGVISNTIQPTPQTIPAIDPALFSTVSQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE", "length": 248, "header": "tr|F1N318-1|F1N318_BOVIN Computationally mapped isoform of Vesicle trafficking 1 OS=Bos taurus OX=9913 GN=VTA1 PE=3 SV=2 CANONICAL=A0AAA9S3S6-1" }, "locus": { "chromosome": "9", "start_pos": 79699148, "end_pos": 79629744, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007693.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007693.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007693.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007693.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506430", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506430", "resource": "KEGG Pathway" }, { "id": "R-BTA-917729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AY26-1", "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "VTA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALAPLPPLPPQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAVTQEIVGSAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGATSLPTQPPQPSSSTYDPGNMPSSSYTGIQIPPGAHAPANTPAEVPHSTGVTSNTIQPTPPGSIPAIDPALFSTVSQGDIRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE", "length": 307 }, "evidence": [ { "id": "A0AAA9S3S6", "url": "https://omabrowser.org/oma/group/A0AAA9S3S6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A2R8RJY3-1", "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "vta1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALPPQLKAIQHYLRTAQEHEKRDPVVAYYCRLYAMQTGMKLDSKTPECRKFLVKLMDQLEMMKKELGDNESISQEIVGNAHIENYALKMFLYADNEDRSERFHKNMIKSFYTSSLLFDVLSVFGELSEENLQQRKYAKWKAAYIHNCLKNGETPQPGPIGMEGEAYDDEFGAEGGGPSQAPDNPPHSQPSFRGHPSDQPPTSNFSNIQIPPGSHAPANTPAEIPHPEAAQPVKPVPVPRTMPVVDPSLLNNTQEGDVRLTPEDFTRAQKYCKYAGSALQYEDVGTAVQNLQKALKLLTTGKE", "length": 303 }, "evidence": [ { "id": "A0AAA9S3S6", "url": "https://omabrowser.org/oma/group/A0AAA9S3S6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HAV4-1", "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "Vta1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAVTQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDVEETEDVGATSLPTQPPQPSSSSTYDPSNLAPGSYSGIQIPPGAHAPANTPAEVPHSTGVTSNTVQPSPQTVPTIDPDMYTTSQGDIRLTPEDFARAQKYCKYAGSALQYEDVGTAVQNLQKALRLLTTGRE", "length": 306 }, "evidence": [ { "id": "A0AAA9S3S6", "url": "https://omabrowser.org/oma/group/A0AAA9S3S6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9CR26-1", "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "Vta1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAVTQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEENDVEENEDVGATSLPTQPPQPSSSSAYDPSNLAPGSYSGIQIPPGAHAPANTPAEVPHSTGVTSNAVQPSPQTVPAAPAVDPDLYTASQGDIRLTPEDFARAQKYCKYAGSALQYEDVGTAVQNLQKALRLLTTGRE", "length": 309 }, "evidence": [ { "id": "A0AAA9S3S6", "url": "https://omabrowser.org/oma/group/A0AAA9S3S6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NP79-1", "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "VTA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAITQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAASLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDVRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE", "length": 307 }, "evidence": [ { "id": "A0AAA9S3S6", "url": "https://omabrowser.org/oma/group/A0AAA9S3S6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W0B3-1", "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "Vta1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEFPPCPPSLKSIQHFLKLAQEHDTRDVVIAYWARLYALQVGLKASTQTGEETKLLLGIMDWLEQMKKQYAENEAITNEVAAQAHIENYALKLFLYADKQDREENFGKNVVKAFYSSGVLYDILQTFGELSEEALHNRKYAKWKAAYIHNCLKNGETPIPGPLPDDDDEAELEGENANASADTSPEDAAGAAAPAPYQPEPDSQPPAPSSPTTSGVVPPTAEEVLNNPNKLPSPPVDEEKPGGFVPYVPTAQPNPATAATIYQPIVPVAGVQITPDQMITAQKYCKYAGSALNYDDVKTAIENLQKALKLLSTGSE", "length": 316 }, "evidence": [ { "id": "A0AAA9S3S6", "url": "https://omabrowser.org/oma/group/A0AAA9S3S6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "late endosome to vacuole transport via multivesicular body sorting pathway", "id": "GO:0032511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S3S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3S6" }, { "id": "PF04652", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04652" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Vta1/callose synthase N-terminal", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 158, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4E4-1", "uniprot_ac": "A0AAA9S4E4", "uniprot_id": "A0AAA9S4E4_BOVIN", "mass": { "chemical_mass": 66161.0, "monoisotopic_mass": 66161.0 }, "refseq": { "ac": "NP_001243501", "name": "proton channel OTOP3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243501" }, "gene_names": [ { "name": "OTOP3", "type": "recommended", "evidence": [ { "id": "A0AAA9S4E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4" } ] }, { "name": "OTOP3", "type": "synonym", "evidence": [ { "id": "NP_001243501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243501" } ] } ], "protein_names": [ { "name": "Otopetrin 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S4E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4/entry#names_and_taxonomy" } ] }, { "name": "proton channel OTOP3", "type": "synonym", "evidence": [ { "id": "NP_001243501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243501" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OTOP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4", "locus": { "chromosome": "19", "start_pos": 56476437, "end_pos": 56489199, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040111", "url": "https://www.ensembl.org/id/ENSBTAG00000040111" } ] } } ], "crossref": [ { "id": "A0AAA9S4E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040111", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100337117", "url": "https://www.ncbi.nlm.nih.gov/gene/100337117", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100337117", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337117", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ACAIFYK", "url": "https://omabrowser.org/oma/group/ACAIFYK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6U7", "url": "https://www.orthodb.org/?gene=F1N6U7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21522", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21522", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21522:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21522:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001243501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243501", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6U7", "url": "https://www.uniprot.org/uniprotkb/F1N6U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6U7-1", "url": "https://www.uniprot.org/uniprotkb/F1N6U7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRKSGTERWTARQPTRTLSPSSAPTEAPPMATPEAQATGEAPAKENQVALGFEQTRAPASPVERSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVLLGGAFTCSMVFNNVAVTLGDVWILLAALKVLSALWLLYYTAGTTRQPHAVLHRDPHAGPVWVRGSLVLFGSCTVCLNVFRVGYDVSHIRCKSQLELVFPAIEVVFISVQTWVLWKHCKDCVQIQTNFTRCGLMLTLATNLLLWLLAVSNDSMHHEIEAELSALMKKISGNGTNTCLCLNITMCEVFRKGYLMLYPFSTEYCLICCTVLFVMWRNVGRRLAPAAGAPPGAPSFHLHGAIFGPLLGLLVLVAGVCVFVLFQIQASGPAIAHQYFTVYYAFYVAALPAMSLACLAGTAIHRLEERELDTLKNPTRSLDVVLLMGAALGQMGISYFSIVAIVATRPHELLNCLILAYSLLLILQHMAQNLFIIEGLHRRPLWEVTPESLAGKWEAEPPRRGSLLELGQDLRRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTVVNFGLPLGVFYRMHSVGGLVEVYLGA", "length": 595, "header": "tr|A0AAA9S4E4-1|A0AAA9S4E4_BOVIN Isoform 1 of Otopetrin 3 OS=Bos taurus OX=9913 GN=OTOP3 PE=3 SV=1 CANONICAL=A0AAA9S4E4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4/entry#A0AAA9S4E4-1", "sequence": { "sequence": "MRRKSGTERWTARQPTRTLSPSSAPTEAPPMATPEAQATGEAPAKENQVALGFEQTRAPASPVERSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVLLGGAFTCSMVFNNVAVTLGDVWILLAALKVLSALWLLYYTAGTTRQPHAVLHRDPHAGPVWVRGSLVLFGSCTVCLNVFRVGYDVSHIRCKSQLELVFPAIEVVFISVQTWVLWKHCKDCVQIQTNFTRCGLMLTLATNLLLWLLAVSNDSMHHEIEAELSALMKKISGNGTNTCLCLNITMCEVFRKGYLMLYPFSTEYCLICCTVLFVMWRNVGRRLAPAAGAPPGAPSFHLHGAIFGPLLGLLVLVAGVCVFVLFQIQASGPAIAHQYFTVYYAFYVAALPAMSLACLAGTAIHRLEERELDTLKNPTRSLDVVLLMGAALGQMGISYFSIVAIVATRPHELLNCLILAYSLLLILQHMAQNLFIIEGLHRRPLWEVTPESLAGKWEAEPPRRGSLLELGQDLRRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTVVNFGLPLGVFYRMHSVGGLVEVYLGA", "length": 595, "header": "tr|A0AAA9S4E4-1|A0AAA9S4E4_BOVIN Isoform 1 of Otopetrin 3 OS=Bos taurus OX=9913 GN=OTOP3 PE=3 SV=1 CANONICAL=A0AAA9S4E4-1" }, "locus": { "chromosome": "19", "start_pos": 56483642, "end_pos": 56476963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100350.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100350.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078132.1" } ] } }, { "isoform_ac": "F1N6U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4/entry#F1N6U7-1", "sequence": { "sequence": "MPAQASGHTAMRRKSGTERWTARQPTRTLSPSSAPTEAPPMATPEAQATGEAPAKENQVALGFEQTRAPASPVERSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVLLGGAFTCSMVFNNVAVTLGDVWILLAALKVLSALWLLYYTAGTTRQPHAVLHRDPHAGPVWVRGSLVLFGSCTVCLNVFRVGYDVSHIRCKSQLELVFPAIEVVFISVQTWVLWKHCKDCVQIQTNFTRCGLMLTLATNLLLWLLAVSNDSMHHEIEAELSALMKKISGNGTNTCLCLNITMCEVFRKGYLMLYPFSTEYCLICCTVLFVMWRNVGRRLAPAAGAPPGAPSFHLHGAIFGPLLGLLVLVAGVCVFVLFQIQASGPAIAHQYFTVYYAFYVAALPAMSLACLAGTAIHRLEERELDTLKNPTRSLDVVLLMGAALGQMGISYFSIVAIVATRPHELLNCLILAYSLLLILQHMAQNLFIIEGLHRRPLWEVTPESLAGKWEAEPPRRGSLLELGQDLRRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTVVNFGLPLGVFYRMHSVGGLVEVYLGA", "length": 605, "header": "tr|F1N6U7-1|F1N6U7_BOVIN Computationally mapped isoform of Otopetrin 3 OS=Bos taurus OX=9913 GN=OTOP3 PE=3 SV=4 CANONICAL=A0AAA9S4E4-1" }, "locus": { "chromosome": "19", "start_pos": 56489021, "end_pos": 56476963, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049720.5", "url": "https://www.ensembl.org/id/ENSBTAT00000049720.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046574.5", "url": "https://www.ensembl.org/id/ENSBTAP00000046574.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 33, "start_aa": "Thr", "end_pos": 33, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100337117", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337117", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "proton channel activity", "id": "GO:0015252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proton transmembrane transport", "id": "GO:1902600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902600", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 537, "end_pos": 539, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 33 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 248, "end_pos": 250 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 537, "end_pos": 539 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5S4-1", "uniprot_ac": "A0AAA9S5S4", "uniprot_id": "A0AAA9S5S4_BOVIN", "mass": { "chemical_mass": 118110.0, "monoisotopic_mass": 118110.0 }, "refseq": {}, "gene_names": [ { "name": "PPP1R13B", "type": "recommended", "evidence": [ { "id": "A0AAA9S5S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 13B", "type": "synonym", "evidence": [ { "id": "A0AAA9S5S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R13B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4", "locus": { "chromosome": "21", "start_pos": 68328805, "end_pos": 68411839, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003559", "url": "https://www.ensembl.org/id/ENSBTAG00000003559" } ] } } ], "crossref": [ { "id": "A0AAA9S5S4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5S4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003559", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003559", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511414", "url": "https://www.ncbi.nlm.nih.gov/gene/511414", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028319", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028319", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511414", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511414", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWL2", "url": "https://www.orthodb.org/?gene=A0A3Q1LWL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BHY2", "url": "https://www.orthodb.org/?gene=E1BHY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24131:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24131:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21801", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21801", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804759", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWL2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWL2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHY2", "url": "https://www.uniprot.org/uniprotkb/E1BHY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHY2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDYMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGGRQTQEQRTQRNVTNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQPYSGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNVEVAMMDKRISELRERLYGKKTQLSRVNGTSSPQSPLSAPGRVAAVGPYIQVPSTGSCPAPGDPAKPQSLTVASSAAHGRSKSANDGNWPTLKQNSSSSVRPPQMAGVDWKDASAEGPLKQGAVSSQPVSLSALSAPEKLGMEIGKVPPPLPGVSKPLPPSYGTYPSPAPVGPGSTNSLERRKEGSLPRPSAGLPSRQKPAPLPPAGGPHQPGSSQQIQQRISVPPSPTYPPAGLPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSTVNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLAPGATQPPPPGESAEKEPEPESPAPPGDGAVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGAPFYQPSPSQDFLGSLADVDNGNTTANGNLGEAGPTPLPAPLPAEPAPASDANDNRLPSPEPEGLLCPPNTHQTAEPAEDDNNNVATAPSTEQAPSPGAEAPSPGEEQAPPALPLSVASTSKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRVIYEVEDPSKPNDEGITPLHNAVCAGHHHIVRFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVVYALWAYEAQNSDELTFREGDALTILRRKDEVETDWWWARLGDREGYVPRNLLGLYPRIKPRQRTLA", "length": 1084, "header": "tr|A0AAA9S5S4-1|A0AAA9S5S4_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 13B OS=Bos taurus OX=9913 GN=PPP1R13B PE=3 SV=1 CANONICAL=A0AAA9S5S4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4/entry#A0A3Q1LWL2-1", "sequence": { "sequence": "MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDYMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGGRQTQEQRTQRNVTNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQPYSGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNVEVAMMDKRISELRERLYGKKTQLSRVNGTSSPQSPLSAPGRVAAVGPYIQVPSTGSCPAPGDPAKPQSLTVASSAAHGRSKSDGRGQPRATRLWTVSHLDAGPGRGPSQCPASPFAKPNDGNWPTLKQNSSSSVRPPQMAGVDWKDASAEGPLKQGAVSSQPVSLSALSAPEKLGMEIGKVPPPLPGVSKPLPPSYGTYPSPAPVGPGSTNSLERRKEGSLPRPSAGLPSRQKPAPLPPAGGPHQPGSSQQIQQRISVPPSPTYPPAGLPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSTVNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLAPGATQPPPPGESAEKEPEPESPAPPGDGAVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGAPFYQPSPSQDFLGSLADVDNGNTTANGNLGEAGPTPLPAPLPAEPAPASDANDNRLPSPEPEGLLCPPNTHQTAEPAEDDNNNVATAPSTEQAPSPGAEAPSPGEEQAPPALPLSVASTSKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRVIYEVEDPSKPNDEGITPLHNAVCAGHHHIVRFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVVYALWAYEAQNSDELTFREGDALTILRRKDEVETDWWWARLGDREGYVPRNLLGLYPRIKPRQRTLA", "length": 1119, "header": "tr|A0A3Q1LWL2-1|A0A3Q1LWL2_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 13B OS=Bos taurus OX=9913 GN=PPP1R13B PE=3 SV=2 CANONICAL=A0AAA9S5S4-1" }, "locus": { "chromosome": "21", "start_pos": 68404115, "end_pos": 68329809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083195.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083195.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059825.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059825.2" } ] } }, { "isoform_ac": "A0AAA9S5N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4/entry#A0AAA9S5N9-1", "sequence": { "sequence": "MPQRSERNHDWFAAKMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDYMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGGRQTQEQRTQRNVTNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQPYSGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNVEVAMMDKRISELRERLYGKKTQLSRVNGTSSPQSPLSAPGRVAAVGPYIQVPSTGSCPAPGDPAKPQSLTVASSAAHGRSKSANDGNWPTLKQNSSSSVRPPQMAGVDWKDASAEGPLKQGAVSSQPVSLSALSAPEKLGMEIGKVPPPLPGVSKPLPPSYGTYPSPAPVGPGSTNSLERRKEGSLPRPSAGLPSRQKPAPLPPAGGPHQPGSSQQIQQRISVPPSPTYPPAGLPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSTVNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLAPGATQPPPPGESAEKEPEPESPAPPGDGAVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGAPFYQPSPSQDFLGSLADVDNGNTTANGNLGEAGPTPLPAPLPAEPAPASDANDNRLPSPEPEGLLCPPNTHQTAEPAEDDNNNVATAPSTEQAPSPGAEAPSPGEEQAPPALPLSVASTSKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRVIYEVEDPSKPNDEGITPLHNAVCAGHHHIVRFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVVYALWAYEAQNSDELTFREGDALTILRRKDEVETDWWWARLGDREGYVPRNLLGLYPRIKPRQRTLA", "length": 1096, "header": "tr|A0AAA9S5N9-1|A0AAA9S5N9_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 13B OS=Bos taurus OX=9913 GN=PPP1R13B PE=3 SV=1 CANONICAL=A0AAA9S5S4-1" }, "locus": { "chromosome": "21", "start_pos": 68411669, "end_pos": 68329809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081238.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081238.1" } ] } }, { "isoform_ac": "A0AAA9S5S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4/entry#A0AAA9S5S4-1", "sequence": { "sequence": "MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDYMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGGRQTQEQRTQRNVTNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQPYSGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNVEVAMMDKRISELRERLYGKKTQLSRVNGTSSPQSPLSAPGRVAAVGPYIQVPSTGSCPAPGDPAKPQSLTVASSAAHGRSKSANDGNWPTLKQNSSSSVRPPQMAGVDWKDASAEGPLKQGAVSSQPVSLSALSAPEKLGMEIGKVPPPLPGVSKPLPPSYGTYPSPAPVGPGSTNSLERRKEGSLPRPSAGLPSRQKPAPLPPAGGPHQPGSSQQIQQRISVPPSPTYPPAGLPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSTVNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLAPGATQPPPPGESAEKEPEPESPAPPGDGAVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGAPFYQPSPSQDFLGSLADVDNGNTTANGNLGEAGPTPLPAPLPAEPAPASDANDNRLPSPEPEGLLCPPNTHQTAEPAEDDNNNVATAPSTEQAPSPGAEAPSPGEEQAPPALPLSVASTSKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRVIYEVEDPSKPNDEGITPLHNAVCAGHHHIVRFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVVYALWAYEAQNSDELTFREGDALTILRRKDEVETDWWWARLGDREGYVPRNLLGLYPRIKPRQRTLA", "length": 1084, "header": "tr|A0AAA9S5S4-1|A0AAA9S5S4_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 13B OS=Bos taurus OX=9913 GN=PPP1R13B PE=3 SV=1 CANONICAL=A0AAA9S5S4-1" }, "locus": { "chromosome": "21", "start_pos": 68404115, "end_pos": 68329809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104057.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104057.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081280.1" } ] } }, { "isoform_ac": "A0AAA9SVL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4/entry#A0AAA9SVL4-1", "sequence": { "sequence": "MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDYMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGGRQTQEQRTQRNVTNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQPYSGKLTGPAAVELKRLYQELQLSRVNGTSSPQSPLSAPGRVAAVGPYIQVPSTGSCPAPGDPAKPQSLTVASSAAHGRSKSANDGNWPTLKQNSSSSVRPPQMAGVDWKDASAEGPLKQGAVSSQPVSLSALSAPEKLGMEIGKVPPPLPGVSKPLPPSYGTYPSPAPVGPGSTNSLERRKEGSLPRPSAGLPSRQKPAPLPPAGGPHQPGSSQQIQQRISVPPSPTYPPAGLPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSTVNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLAPGATQPPPPGESAEKEPEPESPAPPGDGAVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGAPFYQPSPSQDFLGSLADVDNGNTTANGNLGEAGPTPLPAPLPAEPAPASDANDNRLPSPEPEGLLCPPNTHQTAEPAEDDNNNVATAPSTEQAPSPGAEAPSPGEEQAPPALPLSVASTSKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRVIYEVEDPSKPNDEGITPLHNAVCAGHHHIVRFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVVYALWAYEAQNSDELTFREGDALTILRRKDEVETDWWWARLGDREGYVPRNLLGLYPRIKPRQRTLA", "length": 1037, "header": "tr|A0AAA9SVL4-1|A0AAA9SVL4_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 13B OS=Bos taurus OX=9913 GN=PPP1R13B PE=3 SV=1 CANONICAL=A0AAA9S5S4-1" }, "locus": { "chromosome": "21", "start_pos": 68404115, "end_pos": 68329809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091540.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091540.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087227.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087227.1" } ] } }, { "isoform_ac": "E1BHY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4/entry#E1BHY2-1", "sequence": { "sequence": "MPRLKSRHVPGKMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDYMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGGRQTQEQRTQRNVTNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQPYSGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNVEVAMMDKRISELRERLYGKKTQLSRVNGTSSPQSPLSAPGRVAAVGPYIQVPSTGSCPAPGDPAKPQSLTVASSAAHGRSKSANDGNWPTLKQNSSSSVRPPQMAGVDWKDASAEGPLKQGAVSSQPVSLSALSAPEKLGMEIGKVPPPLPGVSKPLPPSYGTYPSPAPVGPGSTNSLERRKEGSLPRPSAGLPSRQKPAPLPPAGGPHQPGSSQQIQQRISVPPSPTYPPAGLPAFPAGDGKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSTVNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLAPGATQPPPPGESAEKEPEPESPAPPGDGAVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGAPFYQPSPSQDFLGSLADVDNGNTTANGNLGEAGPTPLPAPLPAEPAPASDANDNRLPSPEPEGLLCPPNTHQTAEPAEDDNNNVATAPSTEQAPSPGAEAPSPGEEQAPPALPLSVASTSKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRVIYEVEDPSKPNDEGITPLHNAVCAGHHHIVRFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVVYALWAYEAQNSDELTFREGDALTILRRKDEVETDWWWARLGDREGYVPRNLLGLYPRIKPRQRTLA", "length": 1093, "header": "tr|E1BHY2-1|E1BHY2_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 13B OS=Bos taurus OX=9913 GN=PPP1R13B PE=3 SV=4 CANONICAL=A0AAA9S5S4-1" }, "locus": { "chromosome": "21", "start_pos": 68405052, "end_pos": 68329809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004631.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004631.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004631.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004631.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 774, "start_aa": "Thr", "end_pos": 774, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr774", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:511414", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511414", "resource": "KEGG Pathway" }, { "id": "R-BTA-6804759", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804759", "resource": "Reactome", "description": "Regulation of TP53 Activity through Association with Co-factors" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway by p53 class mediator", "id": "GO:0072332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072332", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" }, { "name": "negative regulation of cell cycle", "id": "GO:0045786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 395, "end_pos": 397, "annotation": "n_glycosylation_sequon" }, { "start_pos": 575, "end_pos": 577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 602, "end_pos": 604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S4" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 1013, "end_pos": 1075, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 774 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 328, "end_pos": 330 }, { "start_pos": 395, "end_pos": 397 }, { "start_pos": 575, "end_pos": 577 }, { "start_pos": 602, "end_pos": 604 }, { "start_pos": 761, "end_pos": 763 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S4N1-1", "uniprot_ac": "A0AAA9S4N1", "uniprot_id": "A0AAA9S4N1_BOVIN", "mass": { "chemical_mass": 107568.0, "monoisotopic_mass": 107568.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM67", "type": "recommended", "evidence": [ { "id": "A0AAA9S4N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ] } ], "protein_names": [ { "name": "Transmembrane protein 67", "type": "synonym", "evidence": [ { "id": "A0AAA9S4N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1", "locus": { "chromosome": "14", "start_pos": 70467827, "end_pos": 70513970, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044190", "url": "https://www.ensembl.org/id/ENSBTAG00000044190" } ] } } ], "crossref": [ { "id": "A0AAA9S4N1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S4N1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044190", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044190", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506762", "url": "https://www.ncbi.nlm.nih.gov/gene/506762", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MGL5", "url": "https://www.orthodb.org/?gene=F1MGL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21274", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21274", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21274:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21274:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RX11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4N1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGL5", "url": "https://www.uniprot.org/uniprotkb/F1MGL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 963, "header": "tr|A0AAA9S4N1-1|A0AAA9S4N1_BOVIN Isoform 1 of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RX11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9RX11-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 934, "header": "tr|A0AAA9RX11-1|A0AAA9S4N1_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111600.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111600.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075665.1" } ] } }, { "isoform_ac": "A0AAA9S4N1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9S4N1-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 963, "header": "tr|A0AAA9S4N1-1|A0AAA9S4N1_BOVIN Isoform 1 of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134772.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134772.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080133.1" } ] } }, { "isoform_ac": "A0AAA9SC66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9SC66-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 901, "header": "tr|A0AAA9SC66-1|A0AAA9SC66_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130103.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130103.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083709.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083709.1" } ] } }, { "isoform_ac": "A0AAA9TDJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9TDJ8-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQQSTKLKFVAASYDVRGNFLKWQTLEGGILQCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 975, "header": "tr|A0AAA9TDJ8-1|A0AAA9TDJ8_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096671.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096671.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096198.1" } ] } }, { "isoform_ac": "A0AAA9TDN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9TDN8-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 883, "header": "tr|A0AAA9TDN8-1|A0AAA9TDN8_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091782.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091782.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095001.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095001.1" } ] } }, { "isoform_ac": "A0AAA9TIH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9TIH5-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 967, "header": "tr|A0AAA9TIH5-1|A0AAA9TIH5_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112905.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112905.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098269.1" } ] } }, { "isoform_ac": "A0AAA9TLG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9TLG9-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 949, "header": "tr|A0AAA9TLG9-1|A0AAA9TLG9_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098185.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098185.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099288.1" } ] } }, { "isoform_ac": "A0AAA9TNL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9TNL8-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 702, "header": "tr|A0AAA9TNL8-1|A0AAA9TNL8_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110535.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110535.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099957.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099957.1" } ] } }, { "isoform_ac": "A0AAA9TT21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#A0AAA9TT21-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 957, "header": "tr|A0AAA9TT21-1|A0AAA9TT21_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=1 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116545.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116545.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100213.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100213.1" } ] } }, { "isoform_ac": "F1MGL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1/entry#F1MGL5-1", "sequence": { "sequence": "MATGGRGAVVAMAAGSTLSSASVTLFLSLVLPRVSQAQTFFFPFRQPETCGHNQYFDISALSCVACGSNQRQDAGGTSCVCLPGFQMISNNGGPDITCKKCPEHMKGVTEDGWNCISCPGGLTAEGKCHCPTGHILVERNVNGTLLSQATCELCDESENSFTVANALGNRCVRCEPAFINTSKSCACSEPNILTGGLCLSSTGNFPLRMISTARYGELGISFTSEWFAKYLQSSAAACWVYGNLTSCQALGNMCVMNMNYYDSSTFDACGLFQFIFENTAALGTVHSVSFWRQNLPWLFYGDQLGLAPQILSTTPLPTNFSFKGENQQSTKLKFVAASYDVRGNFLKWQTLEGGILQLCPDTETRLNAAYSFGTTYQQSCEIPVPKILTDFPTPTFYDVYLEYTDENQHQYIWAVPVLNLNLQHKKMFVNKDSSSGKWLLTRRIFLVDTLSGRENDLGSQPRLIRVATQISLSIHLVPNTKNGNIYPPLITIAYHDIDIKDPSSQSVKVSFSVTYEMDQGEAHVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVAKFLVYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPVPAQEKRFVTYVGCGFALKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTVLFLLEVVGFKNLALMDSSSSLSRSPPSYIAPYSRILRYAVSSALWLVIGLIQIVFFAVFYERFIEDKIRQFVDLCCMSNISVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAISSQMRQHYDRIHETLTRKNGPARLLSSSGSTFEQSVKAYHTMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGYSFSSVLYYGNEATLLIYDLMFFCVVDLACQNFILAAFLTYLQQEIFRFIRNAVGQKNLASKTLVDQRFLI", "length": 997, "header": "tr|F1MGL5-1|F1MGL5_BOVIN Computationally mapped isoform of Transmembrane protein 67 OS=Bos taurus OX=9913 GN=TMEM67 PE=4 SV=4 CANONICAL=A0AAA9S4N1-1" }, "locus": { "chromosome": "14", "start_pos": 70513787, "end_pos": 70468928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061587.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061587.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053764.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053764.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "non-canonical Wnt signaling pathway", "id": "GO:0035567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "negative regulation of centrosome duplication", "id": "GO:0010826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" }, { "name": "filamin binding", "id": "GO:0031005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4N1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 742, "end_pos": 744, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 742, "end_pos": 744 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S1P7-1", "uniprot_ac": "A0AAA9S1P7", "uniprot_id": "A0AAA9S1P7_BOVIN", "mass": { "chemical_mass": 59196.0, "monoisotopic_mass": 59196.0 }, "refseq": {}, "gene_names": [ { "name": "TBRG4", "type": "recommended", "evidence": [ { "id": "A0AAA9S1P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ] } ], "protein_names": [ { "name": "FAST kinase domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9S1P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7/entry#names_and_taxonomy" } ] }, { "name": "Protein TBRG4", "type": "synonym", "evidence": [ { "id": "A0AAA9S1P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7/entry#names_and_taxonomy" } ] }, { "name": "Transforming growth factor beta regulator 4", "type": "synonym", "evidence": [ { "id": "A0AAA9S1P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression.", "evidence": [ { "database": "UniProtKB", "id": "F1MP97", "url": "https://www.uniprot.org/uniprotkb/F1MP97#function" }, { "database": "UniProtKB", "id": "ARBA00045209", "url": "https://www.uniprot.org/uniprotkb/ARBA00045209#function" }, { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBRG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7", "locus": { "chromosome": "4", "start_pos": 76531883, "end_pos": 76522735, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010504", "url": "https://www.ensembl.org/id/ENSBTAG00000010504" } ] } } ], "crossref": [ { "id": "A0AAA9S1P7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S1P7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010504", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010504", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23739", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23739", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767855", "url": "https://www.ncbi.nlm.nih.gov/gene/767855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LCILQQA", "url": "https://omabrowser.org/oma/group/LCILQQA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP97", "url": "https://www.uniprot.org/uniprotkb/F1MP97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP97-1", "url": "https://www.uniprot.org/uniprotkb/F1MP97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARLVRRCTCLLREAARLAPAVSPVGQLRLPQGTQKPLTSSATSPSSRLPGLLSEFVEKEQVFTPYTGRQEVEQLIEKATQPEELLELLGSGHCLQQNHAALALIQLSRLLSEKPKDKAALIQDARFWQLLHLVNSQITVVWHGTLVKLLRSLYTLGLPATSKDLRSVEQEVRWRMRRLKYKHLAFLAESSATYMQEQGSRELLAELLVHLERRWAEIEDRRMVVAMMMKTGHLSESLMNRLEDKHVLDRAQSITLPHLCNMLLAFARVNFRPEREDPFFSLVHEKLGSELVGLEPALQVDVVWALCVLQQVREAELQAVLRPEFHTQFLGGKSPKDQSTFQKLLHINATAQLEHPEYTGPLLPTSALVPSPSALEQKMTPLQKELQETLKGLLGSADKGSFMVPTQYGWVLDAEVLLDTESQLLPLRDFVAPHLTPPSGSQPLPPGAKRLAFLRWEFPNFNSRSKDLLGRFMLARRHLLAAGFLLVDVPYYEWMELKSEWQKSAYLKDKMRKAVAEELAK", "length": 522, "header": "tr|A0AAA9S1P7-1|A0AAA9S1P7_BOVIN Isoform 1 of FAST kinase domain-containing protein 4 OS=Bos taurus OX=9913 GN=TBRG4 PE=3 SV=1 CANONICAL=A0AAA9S1P7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7/entry#A0AAA9S1P7-1", "sequence": { "sequence": "MAARLVRRCTCLLREAARLAPAVSPVGQLRLPQGTQKPLTSSATSPSSRLPGLLSEFVEKEQVFTPYTGRQEVEQLIEKATQPEELLELLGSGHCLQQNHAALALIQLSRLLSEKPKDKAALIQDARFWQLLHLVNSQITVVWHGTLVKLLRSLYTLGLPATSKDLRSVEQEVRWRMRRLKYKHLAFLAESSATYMQEQGSRELLAELLVHLERRWAEIEDRRMVVAMMMKTGHLSESLMNRLEDKHVLDRAQSITLPHLCNMLLAFARVNFRPEREDPFFSLVHEKLGSELVGLEPALQVDVVWALCVLQQVREAELQAVLRPEFHTQFLGGKSPKDQSTFQKLLHINATAQLEHPEYTGPLLPTSALVPSPSALEQKMTPLQKELQETLKGLLGSADKGSFMVPTQYGWVLDAEVLLDTESQLLPLRDFVAPHLTPPSGSQPLPPGAKRLAFLRWEFPNFNSRSKDLLGRFMLARRHLLAAGFLLVDVPYYEWMELKSEWQKSAYLKDKMRKAVAEELAK", "length": 522, "header": "tr|A0AAA9S1P7-1|A0AAA9S1P7_BOVIN Isoform 1 of FAST kinase domain-containing protein 4 OS=Bos taurus OX=9913 GN=TBRG4 PE=3 SV=1 CANONICAL=A0AAA9S1P7-1" }, "locus": { "chromosome": "4", "start_pos": 76531681, "end_pos": 76524418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098628.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098628.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076008.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076008.1" } ] } }, { "isoform_ac": "F1MP97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7/entry#F1MP97-1", "sequence": { "sequence": "MAARLVRRCTCLLREAARLAPAVSPVGQLRLPQGTQKPLTSSATSPSSRLPGLLSEFVEKEQVFTPYTGRQEVEQLIEKATQPEELLELLGSGHCLQQNHAALALIQLSRLLSEKPKDKAALIQDARFWQLLHLVNSQITVVWHGTLVKLLRSLYTLGLPATSKDLRSVEQEVRWRMRRLKYKHLAFLAESSATYMQEQGSRELLAELLVHLERRWAEIEDRRMVVAMMMKTGHLSESLMNRLEDKCLELVEQFGPEELRKVLVTLAAQNRRSVPLLRAISYHLVQKPFPLTKSILLDLAYAYGKLGFHQTQVFQRLAADLLPHTPSMTSSEVARCTKSFAFLKWLNLPLFEAFVQHVLDRAQSITLPHLCNMLLAFARVNFRPEREDPFFSLVHEKLGSELVGLEPALQVDVVWALCVLQQVREAELQAVLRPEFHTQFLGGKSPKDQSTFQKLLHINATAQLEHPEYTGPLLPTSALVPSPSALEQKMTPLQKELQETLKGLLGSADKGSFMVPTQYGWVLDAEVLLDTESQLLPLRDFVAPHLTPPSGSQPLPPGAKRLAFLRWEFPNFNSRSKDLLGRFMLARRHLLAAGFLLVDVPYYEWMELKSEWQKSAYLKDKMRKAVAEELAK", "length": 632, "header": "tr|F1MP97-1|F1MP97_BOVIN Computationally mapped isoform of FAST kinase domain-containing protein 4 OS=Bos taurus OX=9913 GN=TBRG4 PE=3 SV=3 CANONICAL=A0AAA9S1P7-1" }, "locus": { "chromosome": "4", "start_pos": 76531681, "end_pos": 76524418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013895.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013895.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013895.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013895.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AC66-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "TBRG4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAARLVQRCCWRHLATFTCSPAAATAALLLPSGKASAARALPHPPPASIHTSVPSTWNADRFSVKEQVEENSNSEHRVILNLIEAATSPQELFQLGELHSLNSNQASLVVTRLSRLAVEKKLETGDILQDERFQQLIEIVDSQISQVWNNTLVGLLKSLYSLGMESSSREMQSVEHEVLWRLRRLSFRQLASLAEFLAVKQGKESKLLSEVIKKLELRWTELEGTRTVVMLIAKVGHISSVLMDRLEDKALELAEQFSPEDIRRITLALAYQNRRSVPLLRAMSYHLIQKHSELNLSILMDLIFAYGKLNFHQPQVFQKIATDLQPHVSAMTPIEVTRCIRSFALLKWLSLPLFEAISQYALDNAKQLSISHLCNIILSFARLNFQPSGSEDFFNMAHEELQGQLDSLEPQLLTDLVWSLCVLQQAKPPYLQRVLAPDFHAVIQGDSSPKAQNLRMKLIQINAAAKLESPEYQGPFLPAGMLNAAEPAAEKVTLLQSSLQEALAGVLGSQDNGRWDVHTIYGWQIDAEMVLNSENKPLPLKDFAAPHLPHSEGTKPLPPGARRVAFLRWEFPNFSNRSKELLGRYAMARRHIQAAGFLVVDVPHYEFLELKLERQRAAYLRDKLHKVVAKELAS", "length": 634 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F3K7-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "tbrg4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTTRLLCRWARWFPRSPRTATASARLQTSTVHHTEPLCLMTLSWIRPSVRHLCQGNELAKIDEGTVPYERTKLIKLVEKASTPDEVLQLWDQHGGTGSEAARCLIQLNLRVVEKGSKGVLLDPRCKSMQDTLNTQLSTVWNGSLVGLLRTLTMLGLPAHAPLLGAIQNEVLWRIRRLSYRHLSYLADWVAFQRKMGYENEVLTSTLLKQLELRWTELSDSRTITILMGRASLFTPSLMDKLEDKALELAESFTAEDMRRVALALASQNRRAVPLLRALSYHLNQKPSFELKTPLLLDIAYVYGKLNFSQTQFFKRLASELLPRLSELSSSEVSRCAKSLALLKWLHLPLFEGFAQHYVSNSEKYSTLQMCNLLMAFAKLNFQLGKEQFYLKVHKALEDSFTSLEPFLKTDLVWSLCVLNQANSDYISSVIKPDFQKKLSAGGIEGRTENYRQKLLNICAYAQLEPLGLAVDASAVLLPDRQSKAESSTSALQKTLHTALWSLANERKQALHTAVKTLYGWTIDGELVVDSENKPIDMENFKAPHLPEGGGADALPEGTRRIAFVAWDFSNFCLKSKDLLGRFAMQKRHLQLAGFIVVEVPYFEFLELKSDWQKVAYLKDKLGKAVAEEMAK", "length": 631 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1ST47-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "TBRG4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASRLVRRCTCLLREAARLAPAMSPVGQPRLTRGAPRTLTSSATSPSSHLPGSLSELVERGQVFTPYPERQEVDHLIERATQPEEILALLGGGHCLHQNRAALMVIQLSRLLSEKPKDKALLIKDARFQHLLRLVNSQINAVWHGTLVKLLRSLYALGLPATSKELQSVEQEVRWRMRRLRYKHLAFLAESSATYMQEQGSQELLAELLVHLERRWTEIDDGRTVVAMMVKIGHLSQSLMNRLEDKHVLDRAQSIALPHLCNMLLAFARVNFRPEREDQFFSLVHEKLGSQLAGLEPALQVDVVWSLCVLQQAREAELQAVLRPELHGQFLGDKSPKDQSTFQKLLHINATAQLEHPEYTGPHLPSSALVPRPSALDKKVTPLQKELQETLKGLLGSANKGSFLVATRYGWILDAEVLLDADSQLLPLRDFVAPHLAQPSGSQPLPAGAKRLAFLCWEFPNFNSRSKDLLGRFVLARRHLLAAGFLLVDVPYYEWLELKSEWQKSAYLKDKMRKAVAEELAK", "length": 522 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HMC7-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "Tbrg4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVRLMKRCTCLLRDTTRLVPTITPVGRVRLAGVACKTLTSSVSSPSSGSLTELLGKEQVFTPYPEHQEVDHLIEKATRPEELLELLGGGYSLHRNHPALILIRLSYLLSEKPKEKALLVEDARFLQLVSRIDSQVSSIWHGTLVKLLRSMYTLVLPQMSKELRSVEQEVRWRLRRLKYKHLVFLVESCTSYMQEQHSQELLAELLMHLERRWTEINDSRTVVTMMMKAGHLSESLMNRLEDKCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRAISYHLVQKPFPLTKGVLLDLAYAYGKLNFHQTQVSQRLAADLLPFVPSMTLGEVARCTKSFAFLKWLNLSLFEAFTQHLLSRVQDVSLTHLCSILLAFARLNFHPEQEDEFFKLVHEKLDSMLGSLEPTLQVDLVWALCVLQQVREAELQTVLHPGLHTQFLGSKSPKDQSTFQKLVHINTTALLEHPEYKGPFLPASAVALCPSSSSKQMTPLQKELQETLKELLGSTDQGRLDVVTQYGWVLDAEVLLDTDGHFLPLRDFVAPHLAQPVGNRPLPPGAKRIAFLRWEFPNFNSRSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSGWQKGAYLKDKMRKAVAEELAK", "length": 629 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5M9G9-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "Tbrg4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVRLMKQCTCLLREATRLVPTVAPVGRLRLAGVACKTLTSSVSSPSSGSLTELLGKEQVFTPYPEHQEVDYLIEKATRPEELLELLGGDHSLHHNHAALILIRLSYLLSEKPKEKALLVEDARFQQLVRLVDSQITSVWHGTLVKLLRSLYTLVLPQGSKELRSVEQEVRWRLRRLKYKHLVFLAESCAPFMKEQHSKELLAELLRHLERRWTEISDSRTLVSMMTMAGHLSESLMNRLEDKCLELVEQFGPDELRKVLMTLAAQSRRSVPLLRAISYHLVQKPFPMTKGMLLDLAYAYGKLSFHQTQVAQRLAADLLPFIPSMTPGEVARCAKSFAFLKWLNLPLFEAFTQHLLNSAQDVSLSHLCSVLLAFARLNFHPEQEDQFFNLVHEKLDSVLGSLEPALQVDLVWALCVLQQVQVAELQTVLHPGLHTRFLESKSPKDQSTFQKLVHINSTALLEYPEYKGPFLPASAVAPSPSPSNKKMTPLQKELQDALKALLGNNDTGSLEVATQYGWVLDAEVLLDAEGHFLPLRDFVAPHLAQPVGNQPLPPGAKRIAFLRWEFPNFNSRSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSEWQKTAYLKDKMRKAVAEELAK", "length": 629 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91YM4-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "Tbrg4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVRLMKRCTCLLREATRLVPTVAPVGRLRLAGVSCKTLTSSVSSPSSGSLAELLGKEQVFTPYPEHQELDFLIEKASRPEQLLELLGSDHSLHHNHAALILIRLSYLLSEKPKEKALLAEDARFQRLVKLVDSQITCVWHGTLVKLLRSLYTLVLPQISKELQSVEQEVRWRLRRLKYKHLVFLAESCASFMKEQHSQELLAELLMHLERRWTEINDSRTLVTMMTMAGHLSESLMNHLEDKCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRAISYHLVQKPFPMTKGMLLDLAYAYGKLSFHQTQVSQRLAADLLPFIPSMTPGEVARCAKSFAFLKWLNLPLFEAFTQHLLSRVQDVSLSHVCSVLLAFARLNFHPEQEEDQFFSMVHEKLDPVLGSLEPALQVDLVWALCVLQHVHETELHTVLHPGLHARFLESKSPKDQSTFQKLVHINTTALLEHPEYKGPFLPASAVAPIPSPSNKKMTPLQKELQETLKALLGNTDKGSLEVATQYGWVLDAEVLLDADGHFLPLRNFVAPHLAQPVGNQPLPPGAKRIAFLRWEFPNFNSRSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSEWQKSAYLKDKMRKAMAEELAK", "length": 630 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969Z0-1", "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "TBRG4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK", "length": 631 }, "evidence": [ { "id": "A0AAA9S1P7", "url": "https://omabrowser.org/oma/group/A0AAA9S1P7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of mitochondrial mRNA stability", "id": "GO:0044528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044528", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "pmid": "" }, { "name": "mitochondrial RNA processing", "id": "GO:0000963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000963", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "pmid": "" }, { "name": "mitochondrial mRNA processing", "id": "GO:0090615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S1P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1P7" }, { "id": "PS51286", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RAP", "eco_id": "ECO_0000259", "start_pos": 452, "end_pos": 510, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 349, "end_pos": 351 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S1Z9-1", "uniprot_ac": "A0AAA9S1Z9", "uniprot_id": "A0AAA9S1Z9_BOVIN", "mass": { "chemical_mass": 166849.0, "monoisotopic_mass": 166849.0 }, "refseq": {}, "gene_names": [ { "name": "CPS1", "type": "recommended", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ] } ], "protein_names": [ { "name": "Carbamoyl-phosphate synthase [ammonia], mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#names_and_taxonomy" } ] }, { "name": "6.3.4.16", "type": "synonym", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#names_and_taxonomy" } ] }, { "name": "Carbamoyl-phosphate synthetase I", "type": "synonym", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGR6#function" }, { "database": "UniProtKB", "id": "ARBA00059545", "url": "https://www.uniprot.org/uniprotkb/ARBA00059545#function" }, { "database": "UniProtKB", "id": "A0ABI0NL15", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL15#function" }, { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9", "locus": { "chromosome": "2", "start_pos": 98467680, "end_pos": 98238683, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016662", "url": "https://www.ensembl.org/id/ENSBTAG00000016662" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016662", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016662", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01423", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01423", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01744", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01744", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005480", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005480", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036480", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036480", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510506", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510506", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FPFNKFP", "url": "https://omabrowser.org/oma/group/FPFNKFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ML89", "url": "https://www.orthodb.org/?gene=F1ML89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11405:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11405:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00117", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00117", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00988", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00988", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02786", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02786", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25596", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25596", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70635", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70635", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "18029", "url": "https://www.rhea-db.org/rhea/18029", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "18633", "url": "https://www.rhea-db.org/rhea/18633", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL15", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL15-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML89", "url": "https://www.uniprot.org/uniprotkb/F1ML89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML89-1", "url": "https://www.uniprot.org/uniprotkb/F1ML89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFSNRFIRKQSQIVFKMTRILTACKVVKTLKTSFGLTNVTAHHQWKFARPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLAGYPEALTDPAYKGQILTMANPIVGNGGAPDTAALDELGLSKYLESDGIKVAGLLVLNYSDDYHHWLATKSLGQWLREEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEISTKDVKVYGKGNPMKVVAVDCGIKNSVIRLLVKRGAEVHVVPWNHDFTKMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNLITGLAAGAQVYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDSTLPAGWKPLFVNVNDQTNEGIMHESKPFFGVQFHPEVGPGPTDTEYLFDSFVSLIKKEKGTTITSVLPKPGLVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFRRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADNIGYPVMIRSAYALGGLGSGLCPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDANDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQLLRRVSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIDGFTSRLPMNKEWPSDIDLRRELADPSSIRIYAIAKALEDNMSLDEIMKLTSIDKWFLYKMRDILNMEKTLKGLNSESITEETLKKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDINFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVGFPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGIDFIDVATKVMIGEHIDEKPLPTLEHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKLPQKGILIGIQQSFRPQFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSPIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVKKARNVDSKSLFHYRQYRAGKEL", "length": 1517, "header": "tr|A0AAA9S1Z9-1|A0AAA9S1Z9_BOVIN Isoform 1 of Carbamoyl-phosphate synthase [ammonia], mitochondrial OS=Bos taurus OX=9913 GN=CPS1 PE=1 SV=1 CANONICAL=A0AAA9S1Z9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#A0AAA9S1Z9-1", "sequence": { "sequence": "MPFSNRFIRKQSQIVFKMTRILTACKVVKTLKTSFGLTNVTAHHQWKFARPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLAGYPEALTDPAYKGQILTMANPIVGNGGAPDTAALDELGLSKYLESDGIKVAGLLVLNYSDDYHHWLATKSLGQWLREEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEISTKDVKVYGKGNPMKVVAVDCGIKNSVIRLLVKRGAEVHVVPWNHDFTKMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNLITGLAAGAQVYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDSTLPAGWKPLFVNVNDQTNEGIMHESKPFFGVQFHPEVGPGPTDTEYLFDSFVSLIKKEKGTTITSVLPKPGLVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFRRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADNIGYPVMIRSAYALGGLGSGLCPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDANDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQLLRRVSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIDGFTSRLPMNKEWPSDIDLRRELADPSSIRIYAIAKALEDNMSLDEIMKLTSIDKWFLYKMRDILNMEKTLKGLNSESITEETLKKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDINFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVGFPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGIDFIDVATKVMIGEHIDEKPLPTLEHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKLPQKGILIGIQQSFRPQFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSPIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVKKARNVDSKSLFHYRQYRAGKEL", "length": 1517, "header": "tr|A0AAA9S1Z9-1|A0AAA9S1Z9_BOVIN Isoform 1 of Carbamoyl-phosphate synthase [ammonia], mitochondrial OS=Bos taurus OX=9913 GN=CPS1 PE=1 SV=1 CANONICAL=A0AAA9S1Z9-1" }, "locus": { "chromosome": "2", "start_pos": 98466668, "end_pos": 98308937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107015.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107015.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076101.1" } ] } }, { "isoform_ac": "A0AAA9TGR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#A0AAA9TGR6-1", "sequence": { "sequence": "SSQIVFKMTRILTACKVVKTLKTSFGLTNVTAHHQWKFARPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLAGYPEALTDPAYKGQILTMANPIVGNGGAPDTAALDELGLSKYLESDGIKVAGLLVLNYSDDYHHWLATKSLGQWLREEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEISTKDVKVYGKGNPMKVVAVDCGIKNSVIRLLVKRGAEVHVVPWNHDFTKMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNLITGLAAGAQVYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDSTLPAGWKPLFVNVNDQTNEGIMHESKPFFGVQFHPEVGPGPTDTEYLFDSFVSLIKKEKGTTITSVLPKPGLVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFRRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADNIGYPVMIRSAYALGGLGSGLCPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDANDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQLLRRVSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIDGFTSRLPMNKEWPSDIDLRRELADPSSIRIYAIAKALEDNMSLDEIMKLTSIDKWFLYKMRDILNMEKTLKGLNSESITEETLKKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDINFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVGFPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGIDFIDVATKVMIGEHIDEKPLPTLEHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKLPQKGILIGIQQSFRPQFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSPIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVKKARNVDSKSLFHYRQYRAGKEL", "length": 1507, "header": "tr|A0AAA9TGR6-1|A0AAA9TGR6_BOVIN Computationally mapped isoform of Carbamoyl-phosphate synthase [ammonia], mitochondrial OS=Bos taurus OX=9913 GN=CPS1 PE=1 SV=1 CANONICAL=A0AAA9S1Z9-1" }, "locus": { "chromosome": "2", "start_pos": 98466668, "end_pos": 98238683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100510.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100510.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095402.1" } ] } }, { "isoform_ac": "A0ABI0NL15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#A0ABI0NL15-1", "sequence": { "sequence": "MTRILTACKVVKTLKTSFGLTNVTAHHQWKFARPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLAGYPEALTDPAYKGQILTMANPIVGNGGAPDTAALDELGLSKYLESDGIKVAGLLVLNYSDDYHHWLATKSLGQWLREEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEISTKDVKVYGKGNPMKVVAVDCGIKNSVIRLLVKRGAEVHVVPWNHDFTKMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNLITGLAAGAQVYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDSTLPAGWKPLFVNVNDQTNEGIMHESKPFFGVQFHPEVGPGPTDTEYLFDSFVSLIKKEKGTTITSVLPKPGLVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFRRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADNIGYPVMIRSAYALGGLGSGLCPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDANDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQLLRRVSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIDGFTSRLPMNKEWPSDIDLRRELADPSSIRIYAIAKALEDNMSLDEIMKLTSIDKWFLYKMRDILNMEKTLKGLNSESITEETLKKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDINFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVGFPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGIDFIDVATKVMIGEHIDEKPLPTLEHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKLPQKGILIGIQVPEGRWRTVRTEANKMTCNCEA", "length": 1389, "header": "tr|A0ABI0NL15-1|A0ABI0NL15_BOVIN Computationally mapped isoform of Carbamoyl-phosphate synthase [ammonia], mitochondrial OS=Bos taurus OX=9913 GN=CPS1 PE=1 SV=1 CANONICAL=A0AAA9S1Z9-1" }, "locus": { "chromosome": "2", "start_pos": 98456148, "end_pos": 98328013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153148.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153148.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105625.1" } ] } }, { "isoform_ac": "F1ML89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9/entry#F1ML89-1", "sequence": { "sequence": "MTRILTACKVVKTLKTSFGLTNVTAHHQWKFARPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLAGYPEALTDPAYKGQILTMANPIVGNGGAPDTAALDELGLSKYLESDGIKVAGLLVLNYSDDYHHWLATKSLGQWLREEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEISTKDVKVYGKGNPMKVVAVDCGIKNSVIRLLVKRGAEVHVVPWNHDFTKMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNLITGLAAGAQVYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDSTLPAGWKPLFVNVNDQTNEGIMHESKPFFGVQFHPEVGPGPTDTEYLFDSFVSLIKKEKGTTITSVLPKPGLVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFRRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADNIGYPVMIRSAYALGGLGSGLCPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDANDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQLLRRVSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIDGFTSRLPMNKEWPSDIDLRRELADPSSIRIYAIAKALEDNMSLDEIMKLTSIDKWFLYKMRDILNMEKTLKGLNSESITEETLKKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDINFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVGFPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGIDFIDVATKVMIGEHIDEKPLPTLEHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEQSFRPQFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSPIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVKKARNVDSKSLFHYRQYRAGKEL", "length": 1467, "header": "tr|F1ML89-1|F1ML89_BOVIN Computationally mapped isoform of Carbamoyl phosphate synthase arginine-specific large chain OS=Bos taurus OX=9913 GN=CPS1 PE=1 SV=3 CANONICAL=A0AAA9S1Z9-1" }, "locus": { "chromosome": "2", "start_pos": 98466668, "end_pos": 98328013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022158.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022158.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022158.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022158.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 402, "start_aa": "Thr", "end_pos": 402, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr402", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510506", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510506", "resource": "KEGG Pathway" }, { "id": "R-BTA-70635", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70635", "resource": "Reactome", "description": "Urea cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "P03965-1", "protein_name": "Carbamoyl phosphate synthase arginine-specific large chain", "gene_name": "CPA2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTSIYTSTEPTNSAFTTEDYKPQLVEGVNSVLVIGSGGLSIGQAGEFDYSGSQAIKALKEDNKFTILVNPNIATNQTSHSLADKIYYLPVTPEYITYIIELERPDAILLTFGGQTGLNCGVALDESGVLAKYNVKVLGTPIKTLITSEDRDLFASALKDINIPIAESFACETVDEALEAAERVKYPVIVRSAYALGGLGSGFANNASEMKELAAQSLSLAPQILVEKSLKGWKEVEYEVVRDRVGNCITVCNMENFDPLGVHTGDSMVFAPSQTLSDEEFHMLRSAAIKIIRHLGVIGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGYTLPELPNPITKTTVANFEPSLDYIVAKIPKWDLSKFQYVDRSIGSSMKSVGEVMAIGRNYEEAFQKALRQVDPSLLGFQGSTEFGDQLDEALRTPTDRRVLAIGQALIHENYTVERVNELSKIDKWFLYKCMNIVNIYKELESVKSLSDLSKDLLQRAKKLGFSDKQIAVTINKHASTNINELEIRSLRKTLGIIPFVKRIDTLAAEFPAQTNYLYTTYNATKNDVEFNENGMLVLGSGVYRIGSSVEFDWCAVNTAKTLRDQGKKTIMINYNPETVSTDFDEVDRLYFEELSYERVMDIYELEQSEGCIISVGGQLPQNIALKLYDNGCNIMGTNPNDIDRAENRHKFSSILDSIDVDQPEWSELTSVEEAKLFASKVNYPVLIRPSYVLSGAAMSVVNNEEELKAKLTLASDVSPDHPVVMSKFIEGAQEIDVDAVAYNGNVLVHAISEHVENAGVHSGDASLVLPPQHLSDDVKIALKDIADKVAKAWKITGPFNMQIIKDGEHTLKVIECNIRASRSFPFVSKVLGVNFIEIAVKAFLGGDIVPKPVDLMLNKKYDYVATKVPQFSFTRLAGADPFLGVEMASTGEVASFGRDLIESYWTAIQSTMNFHVPLPPSGILFGGDTSREYLGQVASIVATIGYRIYTTNETTKTYLQEHIKEKNAKVSLIKFPKNDKRKLRELFQEYDIKAVFNLASKRAESTDDVDYIMRRNAIDFAIPLFNEPQTALLFAKCLKAKIAEKIKILESHDVIVPPEVRSWDEFIGFKAY", "length": 1118 }, "evidence": [ { "id": "A0AAA9S1Z9", "url": "https://omabrowser.org/oma/group/A0AAA9S1Z9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P07756-1", "protein_name": "Carbamoyl-phosphate synthase [ammonia], mitochondrial", "gene_name": "Cps1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTRILTACKVVKTLKSGFGLANVTSKRQWDFSRPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYSEALTDPAYKGQILTMANPIIGNGGAPDTTARDELGLNKYMESDGIKVAGLLVLNYSHDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEVSTKDVKVFGKGNPTKVVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTQMDYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNIITGLAAGAKSYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDNTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKGKGTTITSVLPKPALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADAVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIGYPVMIRSAYALGGLGSGICPNKETLMDLGTKAFAMTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSVDGFTPRLPMNKEWPANLDLRKELSEPSSTRIYAIAKALENNMSLDEIVKLTSIDKWFLYKMRDILNMDKTLKGLNSESVTEETLRQAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDIKFDEHGIMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACNGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFANSVGYPCLLRPSYVLSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFIEGAREVEMDAVGKEGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGESVDEKHLPTLEQPIIPSDYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQKARTVDSKSLFHYRQYSAGKAA", "length": 1500 }, "evidence": [ { "id": "A0AAA9S1Z9", "url": "https://omabrowser.org/oma/group/A0AAA9S1Z9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P31327-1", "protein_name": "Carbamoyl-phosphate synthase [ammonia], mitochondrial", "gene_name": "CPS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKPALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA", "length": 1500 }, "evidence": [ { "id": "A0AAA9S1Z9", "url": "https://omabrowser.org/oma/group/A0AAA9S1Z9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q42601-1", "protein_name": "Carbamoyl phosphate synthase arginine-specific large chain, chloroplastic", "gene_name": "CARB", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MRNHCLELSSNCSSIFASSKSNPRFSPSKLSYSTFFSRSAIYYRSKPKQASSSSSFSTFPPCLNRKSSLTHVLKPVSELADTTTKPFSPEIVGKRTDLKKIMILGAGPIVIGQACEFDYSGTQACKALREEGYEVILINSNPATIMTDPETANRTYIAPMTPELVEQVIEKERPDALLPTMGGQTALNLAVALAESGALEKYGVELIGAKLGAIKKAEDRELFKDAMKNIGLKTPPSGIGTTLDECFDIAEKIGEFPLIIRPAFTLGGTGGGIAYNKEEFESICKSGLAASATSQVLVEKSLLGWKEYELEVMRDLADNVVIICSIENIDPMGVHTGDSITVAPAQTLTDREYQRLRDYSIAIIREIGVECGGSNVQFAVNPVDGEVMIIEMNPRVSRSSALASKATGFPIAKMAAKLSVGYTLDQIPNDITRKTPASFEPSIDYVVTKIPRFAFEKFPGSQPLLTTQMKSVGESMALGRTFQESFQKALRSLECGFSGWGCAKIKELDWDWDQLKYSLRVPNPDRIHAIYAAMKKGMKIDEIYELSMVDKWFLTQLKELVDVEQYLMSGTLSEITKEDLYEVKKRGFSDKQIAFATKTTEEEVRTKRISLGVVPSYKRVDTCAAEFEAHTPYMYSSYDVECESAPNNKKKVLILGGGPNRIGQGIEFDYCCCHTSFALQDAGYETIMLNSNPETVSTDYDTSDRLYFEPLTIEDVLNVIDLEKPDGIIVQFGGQTPLKLALPIKHYLDKHMPMSLSGAGPVRIWGTSPDSIDAAEDRERFNAILDELKIEQPKGGIAKSEADALAIAKEVGYPVVVRPSYVLGGRAMEIVYDDSRLITYLENAVQVDPERPVLVDKYLSDAIEIDVDTLTDSYGNVVIGGIMEHIEQAGVHSGDSACMLPTQTIPASCLQTIRTWTTKLAKKLNVCGLMNCQYAITTSGDVFLLEANPRASRTVPFVSKAIGHPLAKYAALVMSGKSLKDLNFEKEVIPKHVSVKEAVFPFEKFQGCDVILGPEMRSTGEVMSISSEFSSAFAMAQIAAGQKLPLSGTVFLSLNDMTKPHLEKIAVSFLELGFKIVATSGTAHFLELKGIPVERVLKLHEGRPHAADMVANGQIHLMLITSSGDALDQKDGRQLRQMALAYKVPVITTVAGALATAEGIKSLKSSAIKMTALQDFFEVKNVSSLLV", "length": 1187 }, "evidence": [ { "id": "A0AAA9S1Z9", "url": "https://omabrowser.org/oma/group/A0AAA9S1Z9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8C196-1", "protein_name": "Carbamoyl-phosphate synthase [ammonia], mitochondrial", "gene_name": "Cps1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRILTACKVVKTLKSGFGFANVTTKRQWDFSRPGIRLLSVKAKTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEALTDPAYKGQILTMANPIIGNGGAPDTTARDELGLNKYMESDGIKVAGLLVLNYSNDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEVSTKDVKVFGKGNPTKVVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTQMEYDGLLIAGGPGNPALAQPLIQNVKKILESDRKEPLFGISTGNIITGLAAGAKSYKMSMANRGQNQPVLNITNRQAFITAQNHGYALDNTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKGKGTTITSVLPKPALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADAVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIGYPVMIRSAYALGGLGSGICPNKETLIDLGTKAFAMTNQILVERSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSVNVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSVDGFTPRLPMNKEWPANLDLKKELSEPSSTRIYAIAKALENNMSLDEIVRLTSIDKWFLYKMRDILNMDKTLKGLNSDSVTEETLRKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDIKFDEHGIMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACNGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFANSVGYPCLLRPSYVLSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKEGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGESIDEKRLPTLEQPIIPSDYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQKSRTVDSKSLFHYRQYSAGKAA", "length": 1500 }, "evidence": [ { "id": "A0AAA9S1Z9", "url": "https://omabrowser.org/oma/group/A0AAA9S1Z9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "carbamoyl-phosphate synthase (ammonia) activity", "id": "GO:0004087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity", "id": "GO:0004088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "modified amino acid binding", "id": "GO:0072341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072341", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "nitric oxide metabolic process", "id": "GO:0046209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "carbamoyl phosphate biosynthetic process", "id": "GO:0070409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "cellular response to ammonium ion", "id": "GO:0071242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071242", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "vasodilation", "id": "GO:0042311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042311", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "triglyceride catabolic process", "id": "GO:0019433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019433", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "urea cycle", "id": "GO:0000050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "glutamine metabolic process", "id": "GO:0006541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006541", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "homocysteine metabolic process", "id": "GO:0050667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "'de novo' pyrimidine nucleobase biosynthetic process", "id": "GO:0006207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006207", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1458, "end_pos": 1460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 878, "end_pos": 880, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18029", "name": "", "equation": "hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S1Z9-1", "F1MVC0-1" ], "evidence": [ { "id": "18029", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18029" } ] }, { "id": "18633", "name": "", "equation": "hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MVC0-1", "A0AAA9S1Z9-1" ], "evidence": [ { "id": "18633", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18633" } ] }, { "id": "R-BTA-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-113561" ], "output_participant_list": [], "enzyme_list": [ "A0AAA9S1Z9-1" ], "evidence": [ { "id": "R-BTA-70555", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70555" } ] }, { "id": "R-BTA-9955504", "name": "SIRT5 deglutarylates CPS1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-BTA-9955510" ], "output_participant_list": [ "R-ALL-9955515", "R-BTA-70544" ], "enzyme_list": [ "Q3ZBQ0-1", "A0AAA9S1Z9-1" ], "evidence": [ { "id": "R-BTA-9955504", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9955504" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113561", "participant_name": "NH4+ [mitochondrial matrix]", "crossref": [ { "id": "28938", "database": "ChEBI", "url": "" }, { "id": "C01342", "database": "COMPOUND", "url": "" }, { "id": "8144903", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0041827", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-9955515", "participant_name": "2''-O-glutaryl-ADP-D-ribose(3-) [mitochondrial matrix]", "crossref": [ { "id": "ZINC000263614920", "database": "ZINC", "url": "" }, { "id": "87829", "database": "ChEBI", "url": "" }, { "id": "ZINC000263614919", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-BTA-70544", "participant_name": "CPS1 [mitochondrial matrix]", "crossref": [ { "id": "ENSBTAT00000022158", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000016662", "database": "ENSEMBL", "url": "" }, { "id": "F1ML89", "database": "UniProt", "url": "" }, { "id": "27669", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000022158", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-9955510", "participant_name": "CPS1 [mitochondrial matrix]", "crossref": [ { "id": "F1ML89", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000016662", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000022158", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000022158", "database": "ENSEMBL", "url": "" }, { "id": "27669", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S1Z9", "gene_name": "CPS1", "activity": [ { "ec_number": "6.3.4.16", "activity": "hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+).", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ] }, { "ec_number": "6.3.4.16", "activity": "", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ] }, { "ec_number": "6.3.5.5", "activity": "hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+).", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ] }, { "ec_number": "6.3.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" } ] } ] }, { "uniprot_ac": "F1MVC0", "gene_name": "CAD", "activity": [ { "ec_number": "6.3.4.16", "activity": "hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+).", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "2.1.3.2", "activity": "carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+).", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "3.5.2.3", "activity": "(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+).", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "6.3.5.5", "activity": "hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+).", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "3.5.1.2", "activity": "L-glutamine + H2O = L-glutamate + NH4(+).", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "2.1.3.2", "activity": "", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "6.3.4.16", "activity": "", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "6.3.5.5", "activity": "", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "3.5.2.3", "activity": "", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] }, { "ec_number": "3.5.1.2", "activity": "", "evidence": [ { "id": "F1MVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC0" } ] } ] }, { "uniprot_ac": "Q3ZBQ0", "gene_name": "SIRT5", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q3ZBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBQ0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" }, { "id": "PS50975", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50975" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ATP-grasp", "eco_id": "ECO_0000259", "start_pos": 568, "end_pos": 760, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S1Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z9" }, { "id": "PS51855", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51855" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MGS-like", "eco_id": "ECO_0000259", "start_pos": 1372, "end_pos": 1517, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.4.16", "ec_name": "hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+).", "evidence": [ { "id": "6.3.4.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16" }, { "id": "6.3.4.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.4.16" } ] }, { "ec_number": "6.3.5.5", "ec_name": "hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+).", "evidence": [ { "id": "6.3.5.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5" }, { "id": "6.3.5.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.5.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 402 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1458, "end_pos": 1460 }, { "start_pos": 152, "end_pos": 154 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 878, "end_pos": 880 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S3U7-1", "uniprot_ac": "A0AAA9S3U7", "uniprot_id": "A0AAA9S3U7_BOVIN", "mass": { "chemical_mass": 33646.0, "monoisotopic_mass": 33646.0 }, "refseq": { "ac": "XP_005202100", "name": "ICOS ligand isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202100" }, "gene_names": [ { "name": "ICOSLG", "type": "recommended", "evidence": [ { "id": "A0AAA9S3U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ] }, { "name": "ICOSLG", "type": "synonym", "evidence": [ { "id": "XP_005202100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202100" } ] } ], "protein_names": [ { "name": "ICOS ligand", "type": "recommended", "evidence": [ { "id": "A0AAA9S3U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#names_and_taxonomy" } ] }, { "name": "B7 homolog 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S3U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#names_and_taxonomy" } ] }, { "name": "B7-like protein Gl50", "type": "synonym", "evidence": [ { "id": "A0AAA9S3U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#names_and_taxonomy" } ] }, { "name": "B7-related protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S3U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#names_and_taxonomy" } ] }, { "name": "ICOS ligand isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005202100", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202100" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ICOSLG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7", "locus": { "chromosome": "1", "start_pos": 144225435, "end_pos": 144234921, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014880", "url": "https://www.ensembl.org/id/ENSBTAG00000014880" } ] } } ], "crossref": [ { "id": "A0AAA9S3U7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S3U7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014880", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014880", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20935", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20935", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507857", "url": "https://www.ncbi.nlm.nih.gov/gene/507857", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NMV4", "url": "https://www.orthodb.org/?gene=A0A3Q1NMV4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCU8", "url": "https://www.orthodb.org/?gene=E1BCU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100:SF151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100:SF151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9927354", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9927354", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005202100", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202100", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMV4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4N8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4N8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4N8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4N8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU8", "url": "https://www.uniprot.org/uniprotkb/E1BCU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPRSPGLFLLLLWGLQAESQEEVRAMVGSDVQLRCIYPEKNSFDLNDLYVYWQISMAGKGNVDSVVTYHLSGNSSASHGDNHYKDRARLSLDSMKQGDFSLHLRNVTPQDEQKFNCLVFRKSLELKKILEVAVTLHVAANYSMPVVSGPSQDEELTFTCTSTNGYPRPNVYWINKTDNSVLDSALQNNTVSLNARGLYDVVSVLRIGRTPHVNVGCCIENVLLHQNLTSGQTETFTGTKDSITEDPVDGSPSGKHQQVFSVLAVLAVIVLLALATGWLCRSRCPPKSQTGAQVARPKLALAEHV", "length": 305, "header": "tr|A0AAA9S3U7-1|A0AAA9S3U7_BOVIN Isoform 1 of ICOS ligand OS=Bos taurus OX=9913 GN=ICOSLG PE=3 SV=1 CANONICAL=A0AAA9S3U7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NMV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#A0A3Q1NMV4-1", "sequence": { "sequence": "MRPRSPGLFLLLLWGLQAANYSMPVVSGPSQDEELTFTCTSTNGYPRPNVYWINKTDNSVLDSALQNNTVSLNARGLYDVVSVLRIGRTPHVNVGCCIENVLLHQNLTSGQTETFTGTKDSITEDPVDGSPSGKHQQVFSVLAVLAVIVLLALATGWLCRSRCPPKSQTGAQVARPKLALAEHV", "length": 184, "header": "tr|A0A3Q1NMV4-1|A0AAA9S3U7_BOVIN Computationally mapped isoform of ICOS ligand OS=Bos taurus OX=9913 GN=ICOSLG PE=3 SV=2 CANONICAL=A0AAA9S3U7-1" }, "locus": { "chromosome": "1", "start_pos": 144234639, "end_pos": 144226439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077110.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077110.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073984.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073984.2" } ] } }, { "isoform_ac": "A0AAA9S3U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#A0AAA9S3U7-1", "sequence": { "sequence": "MRPRSPGLFLLLLWGLQAESQEEVRAMVGSDVQLRCIYPEKNSFDLNDLYVYWQISMAGKGNVDSVVTYHLSGNSSASHGDNHYKDRARLSLDSMKQGDFSLHLRNVTPQDEQKFNCLVFRKSLELKKILEVAVTLHVAANYSMPVVSGPSQDEELTFTCTSTNGYPRPNVYWINKTDNSVLDSALQNNTVSLNARGLYDVVSVLRIGRTPHVNVGCCIENVLLHQNLTSGQTETFTGTKDSITEDPVDGSPSGKHQQVFSVLAVLAVIVLLALATGWLCRSRCPPKSQTGAQVARPKLALAEHV", "length": 305, "header": "tr|A0AAA9S3U7-1|A0AAA9S3U7_BOVIN Isoform 1 of ICOS ligand OS=Bos taurus OX=9913 GN=ICOSLG PE=3 SV=1 CANONICAL=A0AAA9S3U7-1" }, "locus": { "chromosome": "1", "start_pos": 144234639, "end_pos": 144226439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132986.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132986.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080612.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080612.1" } ] } }, { "isoform_ac": "A0AAA9T4N8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#A0AAA9T4N8-1", "sequence": { "sequence": "MRPRSPGLFLLLLWGLQAESQEEVRAMVGSDVQLRCIYPEKNSFDLNDLYVYWQISMAGKGNVDSVVTYHLSGNSSASHGDNHYKDRARLSLDSMKQGDFSLHLRNVTPQDEQKFNCLVFRKSLELKKILEVAVTLHVAANYSMPVVSGPSQDEELTFTCTSTNGYPRPNVYWINKTDNSVLDSALQNNTVSLNARGLYDVVSVLRIGRTPHVNVGCCIENVLLHQNLTSGQTETFTGTKDSITEDPVDGSPSGKHQQVFSVLAVLAVIVLLALATGWLCRSRCPPKSQTEHV", "length": 293, "header": "tr|A0AAA9T4N8-1|A0AAA9T4N8_BOVIN Computationally mapped isoform of ICOS ligand OS=Bos taurus OX=9913 GN=ICOSLG PE=3 SV=1 CANONICAL=A0AAA9S3U7-1" }, "locus": { "chromosome": "1", "start_pos": 144234639, "end_pos": 144226439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122050.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122050.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091664.1" } ] } }, { "isoform_ac": "E1BCU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7/entry#E1BCU8-1", "sequence": { "sequence": "MRPRSPGLFLLLLWGLQAESQEEVRAMVGSDVQLRCIYPEKNSFDLNDLYVYWQISMAGKGNVDSVVTYHLSGNSSASHGDNHYKDRARLSLDSMKQGDFSLHLRNVTPQDEQKFNCLVFRKSLELKKILEVAVTLHVAANYSMPVVSGPSQDEELTFTCTSTNGYPRPNVYWINKTDNSVLDSALQNNTVSLNARGLYDVVSVLRIGRTPHVNVGCCIENVLLHQNLTSGQTETFTGTKDSITEDPVDGSPSGKHQQVFSVLAVLAVIVLLALATGWLCRSRCPPKSQTGAQVARPKLALAVPTQT", "length": 307, "header": "tr|E1BCU8-1|E1BCU8_BOVIN Computationally mapped isoform of ICOS ligand OS=Bos taurus OX=9913 GN=ICOSLG PE=3 SV=3 CANONICAL=A0AAA9S3U7-1" }, "locus": { "chromosome": "1", "start_pos": 144234639, "end_pos": 144226935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019810.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019810.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019810.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019810.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9927354", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9927354", "resource": "Reactome", "description": "Co-stimulation by ICOS" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "B cell activation", "id": "GO:0042113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042113", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "positive regulation of activated T cell proliferation", "id": "GO:0042104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" }, { "name": "T follicular helper cell differentiation", "id": "GO:0061470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061470", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S3U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U7" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 127, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 141, "end_pos": 143 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 227, "end_pos": 229 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S3Y0-1", "uniprot_ac": "A0AAA9S3Y0", "uniprot_id": "A0AAA9S3Y0_BOVIN", "mass": { "chemical_mass": 65823.0, "monoisotopic_mass": 65823.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF10", "type": "recommended", "evidence": [ { "id": "A0AAA9S3Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ] } ], "protein_names": [ { "name": "Zinc finger protein 10", "type": "synonym", "evidence": [ { "id": "A0AAA9S3Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1B9J8", "url": "https://www.uniprot.org/uniprotkb/E1B9J8#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0#function" }, { "database": "UniProtKB", "id": "A0ABI0NXI0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0", "locus": { "chromosome": "17", "start_pos": 44169646, "end_pos": 44156969, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039242", "url": "https://www.ensembl.org/id/ENSBTAG00000039242" } ] } } ], "crossref": [ { "id": "A0AAA9S3Y0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S3Y0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039242", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039242", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140756", "url": "https://www.ncbi.nlm.nih.gov/gene/100140756", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXI0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXI0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9J8", "url": "https://www.uniprot.org/uniprotkb/E1B9J8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9J8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9J8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTELGILTLVTFKDILVNFTREEWKLLDTAQQIMYKDVMLENYRNLVSLGHQLPKPDVILRLEKGEEPWLVEREIHQETQPDLETSVEIKSTSHKSISNDKYSCDVKMERMPKSDLWYLSLEEVWTCGGQLDRPQDSQERHLRQVAFTQKKVLPQERVCENGKYRGNCFLHSQLVLQEYFCKHDSNPKGLKHNLVFSGHQESCASNSNESSQTFCQNIRLIQFARTQARDKSYRCPGNNSLTHGTSLGISKGAHREKPYECKECGKFFSWRSNLTRHRLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECSECGKSYSQRSHLVVHHRTHTGLKPFECKDCGKCFSRSSHLFSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRVHVGDETYKCNQCGIIFSQNSPLIVYQIAHTGEQFLTCNQCGTALVNTPNVIRYQTNIIRENAY", "length": 568, "header": "tr|A0AAA9S3Y0-1|A0AAA9S3Y0_BOVIN Isoform 1 of Zinc finger protein 10 OS=Bos taurus OX=9913 GN=ZNF10 PE=3 SV=1 CANONICAL=A0AAA9S3Y0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0/entry#A0AAA9S3Y0-1", "sequence": { "sequence": "MMTELGILTLVTFKDILVNFTREEWKLLDTAQQIMYKDVMLENYRNLVSLGHQLPKPDVILRLEKGEEPWLVEREIHQETQPDLETSVEIKSTSHKSISNDKYSCDVKMERMPKSDLWYLSLEEVWTCGGQLDRPQDSQERHLRQVAFTQKKVLPQERVCENGKYRGNCFLHSQLVLQEYFCKHDSNPKGLKHNLVFSGHQESCASNSNESSQTFCQNIRLIQFARTQARDKSYRCPGNNSLTHGTSLGISKGAHREKPYECKECGKFFSWRSNLTRHRLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECSECGKSYSQRSHLVVHHRTHTGLKPFECKDCGKCFSRSSHLFSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRVHVGDETYKCNQCGIIFSQNSPLIVYQIAHTGEQFLTCNQCGTALVNTPNVIRYQTNIIRENAY", "length": 568, "header": "tr|A0AAA9S3Y0-1|A0AAA9S3Y0_BOVIN Isoform 1 of Zinc finger protein 10 OS=Bos taurus OX=9913 GN=ZNF10 PE=3 SV=1 CANONICAL=A0AAA9S3Y0-1" }, "locus": { "chromosome": "17", "start_pos": 44168642, "end_pos": 44160427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108141.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108141.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077984.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077984.1" } ] } }, { "isoform_ac": "A0ABI0NXI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0/entry#A0ABI0NXI0-1", "sequence": { "sequence": "MEAELLTVRSHTLVTFKDILVNFTREEWKLLDTAQQIMYKDVMLENYRNLVSLGHQLPKPDVILRLEKGEEPWLVEREIHQETQPDLETSVEIKSTSHKSISNDKYSCDVKMERMPKSDLWYLSLEEVWTCGGQLDRPQDSQERHLRQVAFTQKKVLPQERVCENGKYRGNCFLHSQLVLQEYFCKHDSNPKGLKHNLVFSGHQESCASNSNESSQTFCQNIRLIQFARTQARDKSYRCPGNNSLTHGTSLGISKGAHREKPYECKECGKFFSWRSNLTRHRLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECSECGKSYSQRSHLVVHHRTHTGLKPFECKDCGKCFSRSSHLFSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRVHVGDETYKCNQCGIIFSQNSPLIVYQIAHTGEQFLTCNQCGTALVNTPNVIRYQTNIIRENAY", "length": 571, "header": "tr|A0ABI0NXI0-1|A0ABI0NXI0_BOVIN Computationally mapped isoform of Zinc finger protein 10 OS=Bos taurus OX=9913 GN=ZNF10 PE=3 SV=1 CANONICAL=A0AAA9S3Y0-1" }, "locus": { "chromosome": "17", "start_pos": 44168642, "end_pos": 44160133, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142749.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142749.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105913.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105913.1" } ] } }, { "isoform_ac": "E1B9J8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0/entry#E1B9J8-1", "sequence": { "sequence": "MSKKRLAFLKRLTKRLTSKLYRSHPKYMEKLHLLDISCFSGSSVRNKEGMEAELLTVRSHTLVTFKDILVNFTREEWKLLDTAQQIMYKDVMLENYRNLVSLGHQLPKPDVILRLEKGEEPWLVEREIHQETQPDLETSVEIKSTSHKSISNDKYSCDVKMERMPKSDLWYLSLEEVWTCGGQLDRPQDSQERHLRQVAFTQKKVLPQERVCENGKYRGNCFLHSQLVLQEYFCKHDSNPKGLKHNLVFSGHQESCASNSNESSQTFCQNIRLIQFARTQARDKSYRCPGNNSLTHGTSLGISKGAHREKPYECKECGKFFSWRSNLTRHRLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECSECGKSYSQRSHLVVHHRTHTGLKPFECKDCGKCFSRSSHLFSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRVHVGDETYKCNQCGIIFSQNSPLIVYQIAHTGEQFLTCNQCGTALVNTPNVIRYQTNIIRENAY", "length": 620, "header": "tr|E1B9J8-1|E1B9J8_BOVIN Computationally mapped isoform of Zinc finger protein 10 OS=Bos taurus OX=9913 GN=ZNF10 PE=3 SV=4 CANONICAL=A0AAA9S3Y0-1" }, "locus": { "chromosome": "17", "start_pos": 44168642, "end_pos": 44158373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056931.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056931.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053058.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053058.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S3Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 260, "end_pos": 287, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S3Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y0" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 82, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 239, "end_pos": 241 }, { "start_pos": 274, "end_pos": 276 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9F2-1", "uniprot_ac": "A0AAA9S9F2", "uniprot_id": "A0AAA9S9F2_BOVIN", "mass": { "chemical_mass": 63782.0, "monoisotopic_mass": 63782.0 }, "refseq": {}, "gene_names": [ { "name": "MAVS", "type": "recommended", "evidence": [ { "id": "A0AAA9S9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ] } ], "protein_names": [ { "name": "Mitochondrial antiviral-signaling protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2/entry#names_and_taxonomy" } ] }, { "name": "Interferon beta promoter stimulator protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2/entry#names_and_taxonomy" } ] }, { "name": "Virus-induced-signaling adapter", "type": "synonym", "evidence": [ { "id": "A0AAA9S9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAVS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2", "locus": { "chromosome": "13", "start_pos": 51338286, "end_pos": 51350832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013545", "url": "https://www.ensembl.org/id/ENSBTAG00000013545" } ] } } ], "crossref": [ { "id": "A0AAA9S9F2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9F2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013545", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013545", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618508", "url": "https://www.ncbi.nlm.nih.gov/gene/618508", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PHIDQKF", "url": "https://omabrowser.org/oma/group/PHIDQKF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIH6", "url": "https://www.orthodb.org/?gene=A0A3Q1MIH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MU42", "url": "https://www.orthodb.org/?gene=F1MU42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21446", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21446", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21446:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21446:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16739", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16739", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-168928", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168928", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-936440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-936440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MIH6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIH6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU42", "url": "https://www.uniprot.org/uniprotkb/F1MU42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU42-1", "url": "https://www.uniprot.org/uniprotkb/F1MU42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEIRVCLPIVEGLRDSSVGKESVCNAGDPGWIPEWGRSTGERIGYPLQCSWASFVAQLPLFLSVHSPFMGQFRTQTVMTFAEDKTYEYIRYNHSNFCNIHVLDILPHLSCLTINDQDRLRAHFDRWGNQGTLWNLFDSLRRRNGWVDSFIRALRACEHTVLADEVAHVYQSNLPRSPNHPPAPLEPPSIPAEIPRPSTPAVAPSIPDNGHTEYEPSYPVPVQDTQPPESLGENSEKAPQPSHSGAVLKRLGGPLEPLSDTVALSTLTSSVHQEQDTELGNTHTAGVVSSSTSLRGPVSPTVSFQPLARSTPRASRLPGPPVSAPSVGTSSSSTGLTSAGGAGDQTEGTICSSGAGVPNNPMAASTVPSKVPTNSAFGSSVPSKLPTSLKPPGAVPTNLAPSRLPINSVRSGMVPPKVPTSGIPDHRIPASTVPSKVPANTRLTIRSSNRLVKETPASPVPTGTATGGTSLWPDSSSDCCGSELELSKPGRLVSRMDSQPFSVCSADLAISHSNSLGMGPDNAPEENEYVSEDTIRIHENPSTSLLGDSPGTYTTPEEDELKELPVVRTMPWASWLGVAMAGALLVLLASLYRRRLPQ", "length": 598, "header": "tr|A0AAA9S9F2-1|A0AAA9S9F2_BOVIN Isoform 1 of Mitochondrial antiviral-signaling protein OS=Bos taurus OX=9913 GN=MAVS PE=4 SV=1 CANONICAL=A0AAA9S9F2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2/entry#A0A3Q1MIH6-1", "sequence": { "sequence": "MQKNVSPDSLLGPPWILWEGRRDLVTTTEFSVPLLKAQSSLILLTSVVGSRPTRGIALVVGKGSHAACGHGASGQQPLFLSVHSPFMGQFRTQTVMTFAEDKTYEYIRYNHSNFCNIHVLDILPHLSCLTINDQDRLRAHFDRWGNQGTLWNLFDSLRRRNGWVDSFIRALRACEHTVLADEVAHVYQSNLPRSPNHPPAPLEPPSIPAEIPRPSTPAVAPSIPDNGHTEYEPSYPVPVQDTQPPESLGENSEKAPQPSHSGAVLKRLGGPLEPLSDTVALSTLTSSVHQEQDTELGNTHTAGVVSSSTSLRGPVSPTVSFQPLARSTPRASRLPGPPVSAPSVGTSSSSTGLTSAGGAGDQTEGTICSSGAGVPNNPMAASTVPSKVPTNSAFGSSVPSKLPTSLKPPGAVPTNLAPSRLPINSVRSGMVPPKVPTSGIPDHRIPASTVPSKVPANTRLTIRSSNRLVKETPASPVPTGTATGGTSLWPDSSSDCCGSELELSKPGRLVSRMDSQPFSVCSADLAISHSNSLGMGPDNAPEENEYVSEDTIRIHENPSTSLLGDSPGTYTTPEEDELKELPVVRTMPWASWLGVAMAGALLVLLASLYRRRLPQ", "length": 615, "header": "tr|A0A3Q1MIH6-1|A0AAA9S9F2_BOVIN Computationally mapped isoform of Mitochondrial antiviral-signaling protein OS=Bos taurus OX=9913 GN=MAVS PE=4 SV=1 CANONICAL=A0AAA9S9F2-1" }, "locus": { "chromosome": "13", "start_pos": 51349100, "end_pos": 51339432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085261.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085261.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071082.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071082.1" } ] } }, { "isoform_ac": "A0AAA9S9F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2/entry#A0AAA9S9F2-1", "sequence": { "sequence": "MKEIRVCLPIVEGLRDSSVGKESVCNAGDPGWIPEWGRSTGERIGYPLQCSWASFVAQLPLFLSVHSPFMGQFRTQTVMTFAEDKTYEYIRYNHSNFCNIHVLDILPHLSCLTINDQDRLRAHFDRWGNQGTLWNLFDSLRRRNGWVDSFIRALRACEHTVLADEVAHVYQSNLPRSPNHPPAPLEPPSIPAEIPRPSTPAVAPSIPDNGHTEYEPSYPVPVQDTQPPESLGENSEKAPQPSHSGAVLKRLGGPLEPLSDTVALSTLTSSVHQEQDTELGNTHTAGVVSSSTSLRGPVSPTVSFQPLARSTPRASRLPGPPVSAPSVGTSSSSTGLTSAGGAGDQTEGTICSSGAGVPNNPMAASTVPSKVPTNSAFGSSVPSKLPTSLKPPGAVPTNLAPSRLPINSVRSGMVPPKVPTSGIPDHRIPASTVPSKVPANTRLTIRSSNRLVKETPASPVPTGTATGGTSLWPDSSSDCCGSELELSKPGRLVSRMDSQPFSVCSADLAISHSNSLGMGPDNAPEENEYVSEDTIRIHENPSTSLLGDSPGTYTTPEEDELKELPVVRTMPWASWLGVAMAGALLVLLASLYRRRLPQ", "length": 598, "header": "tr|A0AAA9S9F2-1|A0AAA9S9F2_BOVIN Isoform 1 of Mitochondrial antiviral-signaling protein OS=Bos taurus OX=9913 GN=MAVS PE=4 SV=1 CANONICAL=A0AAA9S9F2-1" }, "locus": { "chromosome": "13", "start_pos": 51349567, "end_pos": 51339432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098277.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098277.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082707.1" } ] } }, { "isoform_ac": "F1MU42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2/entry#F1MU42-1", "sequence": { "sequence": "MGQFRTQTVMTFAEDKTYEYIRYNHSNFCNIHVLDILPHLSCLTINDQDRLRAHFDRWGNQGTLWNLFDSLRRRNGWVDSFIRALRACEHTVLADEVAHVYQSNLPRSPNHPPAPLEPPSIPAEIPRPSTPAVAPSIPDNGHTEYEPSYPVPVQDTQPPESLGENSEKAPQPSHSGAVLKRLGGPLEPLSDTVALSTLTSSVHQEQDTELGNTHTAGVVSSSTSLRGPVSPTVSFQPLARSTPRASRLPGPPVSAPSVGTSSSSTGLTSAGGAGDQTEGTICSSGAGVPNNPMAASTVPSKVPTNSAFGSSVPSKLPTSLKPPGAVPTNLAPSRLPINSVRSGMVPPKVPTSGIPDHRIPASTVPSKVPANTRLTIRSSNRLVKETPASPVPTGTATGGTSLWPDSSSDCCGSELELSKPGRLVSRMDSQPFSVCSADLAISHSNSLGMGPDNAPEENEYVSEDTIRIHENPSTSLLGDSPGTYTTPEEDELKELPVVRTMPWASWLGVAMAGALLVLLASLYRRRLPQ", "length": 529, "header": "tr|F1MU42-1|A0AAA9S9F2_BOVIN Computationally mapped isoform of Mitochondrial antiviral-signaling protein OS=Bos taurus OX=9913 GN=MAVS PE=4 SV=2 CANONICAL=A0AAA9S9F2-1" }, "locus": { "chromosome": "13", "start_pos": 51346623, "end_pos": 51339432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018013.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018013.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018013.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018013.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 199, "start_aa": "Thr", "end_pos": 199, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr199", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 301, "start_aa": "Thr", "end_pos": 301, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-168928", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168928", "resource": "Reactome", "description": "DDX58/IFIH1-mediated induction of interferon-alpha/beta" }, { "id": "R-BTA-936440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-936440", "resource": "Reactome", "description": "Negative regulators of DDX58/IFIH1 signaling" }, { "id": "R-BTA-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "Q66HG9-1", "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "Mavs", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTFAEEKTYKYIRYNHSKFCCVDVLEILPYLSCLTTSDQDRLRASYKQLGNQGTLWELFNTLQRRPGWVEVFIRALRICELPGLAEQVTRVYQSYLPPGASLHSLDPLQSPRIPTTVSEPSAFAAGHTIPDSGFQDKPGYPKPVQDTQPPKSPVENSEEPPQANFGAIPRMSGDSLISSPNPPALSPQPSREHPEQEPELGGPSTANVDSVPIATYGPVSPTVSFQPLPRIAPRTNLSPGVTVSALSAKTTLSSSSTGSAFAKGAGDQAKAATCVSTKEGVPTNSVTTSSVPSIKPVPVNTMSSKLPISTKSTAATPSTVPTNIAPSKLPINSVYTGIVPSKVTASVAKASASTMPPERNNKQAKETLEAPATVVTTGSSLTRPDISSRSLHSGPELSKPGVLVSQVDNEPFSACSMDLAISPSTSLGSEPNHGPEENEYSSFRIQVDKSPSVDLLGSPEPLATQQSPEEEEPCASSVSWAKWLGATSALLAAFLAVMLYRSRHLAQ", "length": 507 }, "evidence": [ { "id": "A0AAA9S9F2", "url": "https://omabrowser.org/oma/group/A0AAA9S9F2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z434-1", "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "MAVS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH", "length": 540 }, "evidence": [ { "id": "A0AAA9S9F2", "url": "https://omabrowser.org/oma/group/A0AAA9S9F2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCF0-1", "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "Mavs", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTFAEDKTYKYIRDNHSKFCCVDVLEILPYLSCLTASDQDRLRASYRQIGNRDTLWGLFNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPGTSLRSLEPLQLPDFPAAVSGPSAFAPGHNIPDHGLRETPSCPKPVQDTQPPESPVENSEQLLQTNSGAVARMSGGSLIPSPNQQALSPQPSREHQEQEPELGGAHAANVASVPIATYGPVSPTVSFQPLPRTALRTNLLSGVTVSALSADTSLSSSSTGSAFAKGAGDQAKAATCFSTTLTNSVTTSSVPSPRLVPVKTMSSKLPLSSKSTAAMTSTVLTNTAPSKLPSNSVYAGTVPSRVPASVAKAPANTIPPERNSKQAKETPEGPATKVTTGGNQTGPNSSIRSLHSGPEMSKPGVLVSQLDEPFSACSVDLAISPSSSLVSEPNHGPEENEYSSFRIQVDESPSADLLGSPEPLATQQPQEEEEHCASSMPWAKWLGATSALLAVFLAVMLYRSRRLAQ", "length": 503 }, "evidence": [ { "id": "A0AAA9S9F2", "url": "https://omabrowser.org/oma/group/A0AAA9S9F2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 22, "go_terms": [ { "name": "positive regulation of protein import into nucleus", "id": "GO:0042307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "cellular response to exogenous dsRNA", "id": "GO:0071360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "protein localization to mitochondrion", "id": "GO:0070585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070585", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "regulation of peroxisome organization", "id": "GO:1900063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900063", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "negative regulation of viral genome replication", "id": "GO:0045071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of defense response to virus by host", "id": "GO:0002230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of interleukin-8 production", "id": "GO:0032757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032757", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of chemokine (C-C motif) ligand 5 production", "id": "GO:0071651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071651", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of type I interferon-mediated signaling pathway", "id": "GO:0060340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of NLRP3 inflammasome complex assembly", "id": "GO:1900227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "positive regulation of IP-10 production", "id": "GO:0071660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071660", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "cytoplasmic pattern recognition receptor signaling pathway", "id": "GO:0002753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002753", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "CARD domain binding", "id": "GO:0050700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "molecular condensate scaffold activity", "id": "GO:0140693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F2" }, { "id": "PF16739", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16739" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Caspase recruitment", "eco_id": "ECO_0000259", "start_pos": 84, "end_pos": 169, "start_aa": "Asp", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 199, 301 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA20-1", "uniprot_ac": "A0AAA9SA20", "uniprot_id": "A0AAA9SA20_BOVIN", "mass": { "chemical_mass": 292551.0, "monoisotopic_mass": 292551.0 }, "refseq": {}, "gene_names": [ { "name": "GCN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ] } ], "protein_names": [ { "name": "Stalled ribosome sensor GCN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#names_and_taxonomy" } ] }, { "name": "GCN1 eIF-2-alpha kinase activator homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#names_and_taxonomy" } ] }, { "name": "GCN1-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#names_and_taxonomy" } ] }, { "name": "General control of amino-acid synthesis 1-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#names_and_taxonomy" } ] }, { "name": "Translational activator GCN1", "type": "synonym", "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20", "locus": { "chromosome": "17", "start_pos": 62501457, "end_pos": 62556882, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017379", "url": "https://www.ensembl.org/id/ENSBTAG00000017379" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017379", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017379", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536143", "url": "https://www.ncbi.nlm.nih.gov/gene/536143", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057546", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057546", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536143", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536143", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M037", "url": "https://www.orthodb.org/?gene=A0A3Q1M037", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N191", "url": "https://www.orthodb.org/?gene=A0A3Q1N191", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N9S1", "url": "https://www.orthodb.org/?gene=A0A3Q1N9S1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MZT7", "url": "https://www.orthodb.org/?gene=F1MZT7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23346:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23346:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24984", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24984", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24987", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24987", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24993", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24993", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25801", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25801", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26715", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26715", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M037", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M037", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M037-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M037-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N191", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N191", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N191-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N191-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9S1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9S1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S334", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S334", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S334-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S334-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZT7", "url": "https://www.uniprot.org/uniprotkb/F1MZT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZT7-1", "url": "https://www.uniprot.org/uniprotkb/F1MZT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFLVEVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGSEGKLTIVAQKMSVLSGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKCLQNPSSDIRLVAEKMIWWANKDPLPALDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLCKILDVASLEVLNECNRRSLKKLAGQADSTEQVDDTILT", "length": 2671, "header": "tr|A0AAA9SA20-1|A0AAA9SA20_BOVIN Isoform 1 of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=1 CANONICAL=A0AAA9SA20-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M037-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#A0A3Q1M037-1", "sequence": { "sequence": "MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKCLQNPSSDIRLVAEKMIWWANKDPLPALDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLCKILDVASLEVLNECNRRSLKKLAGQADSTEQVDDTILT", "length": 2654, "header": "tr|A0A3Q1M037-1|A0AAA9SA20_BOVIN Computationally mapped isoform of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=2 CANONICAL=A0AAA9SA20-1" }, "locus": { "chromosome": "17", "start_pos": 62556500, "end_pos": 62502053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082620.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082620.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063301.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063301.2" } ] } }, { "isoform_ac": "A0A3Q1N191-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#A0A3Q1N191-1", "sequence": { "sequence": "MTSLKNLSVLFFTFVLTGSQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGSEGKLTIVAQKMSVLSGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKCLQNPSSDIRLVAEKMIWWANKDPLPALDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLCKILDVASLEVLNECNRRSLKKLAGQADSTEQVDDTILT", "length": 2685, "header": "tr|A0A3Q1N191-1|A0AAA9SA20_BOVIN Computationally mapped isoform of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=2 CANONICAL=A0AAA9SA20-1" }, "locus": { "chromosome": "17", "start_pos": 62555016, "end_pos": 62502053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067512.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067512.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062733.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062733.2" } ] } }, { "isoform_ac": "A0A3Q1N9S1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#A0A3Q1N9S1-1", "sequence": { "sequence": "MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGSEGKLTIVAQKMSVLSGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDEVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKCLQNPSSDIRLVAEKMIWWANKDPLPALDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLCKILDVASLEVLNECNRRSLKKLAGQADSTEQVDDTILT", "length": 2644, "header": "tr|A0A3Q1N9S1-1|A0AAA9SA20_BOVIN Computationally mapped isoform of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=2 CANONICAL=A0AAA9SA20-1" }, "locus": { "chromosome": "17", "start_pos": 62556500, "end_pos": 62502053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074776.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074776.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067914.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067914.2" } ] } }, { "isoform_ac": "A0AAA9S334-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#A0AAA9S334-1", "sequence": { "sequence": "MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGSEGKLTIVAQKMSVLSGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKCLQNPSSDIRLVAEKMIWWANKDPLPALDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLCKILDVASLEVLNECNRRSLKKLAGQADSTEQVDDTILT", "length": 2671, "header": "tr|A0AAA9S334-1|A0AAA9SA20_BOVIN Computationally mapped isoform of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=1 CANONICAL=A0AAA9SA20-1" }, "locus": { "chromosome": "17", "start_pos": 62556500, "end_pos": 62502053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098619.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098619.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077679.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077679.1" } ] } }, { "isoform_ac": "A0AAA9SA20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#A0AAA9SA20-1", "sequence": { "sequence": "MGFLVEVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGSEGKLTIVAQKMSVLSGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKCLQNPSSDIRLVAEKMIWWANKDPLPALDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLCKILDVASLEVLNECNRRSLKKLAGQADSTEQVDDTILT", "length": 2671, "header": "tr|A0AAA9SA20-1|A0AAA9SA20_BOVIN Isoform 1 of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=1 CANONICAL=A0AAA9SA20-1" }, "locus": { "chromosome": "17", "start_pos": 62554179, "end_pos": 62502053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133001.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133001.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082160.1" } ] } }, { "isoform_ac": "F1MZT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20/entry#F1MZT7-1", "sequence": { "sequence": "MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALSWTGLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDSAVKKLTKLWRENPGLVEQYLSAILSLEPNQSYAGMLGLLVQFCTSHKEMDVANQHKSALLDFYVKNILMSKVKPQKYLLDNCAPLLRYVSHSEFKDLVLPTIQKSLLRSPENVIETISSLLASVTLDLSQYALDIGKGLAGQLKSNSPRLMDEAVLALRNLARQCSDSSAMEALARHLFAILGGSEGKLTIVAQKMSVLSGIGSVSHHVVSGPSSQVLSGTVAELFIPFLQQEVHEGTLVHAVSVLALWCHRFTTEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLVCFRGDTLLQALDLLPLLIQTVEKAASQGTQVPVVTEGVAAALLLTKLSMADSQAEAKLSGFWQLILDEKKQVFTSEKFLLMASEDALCTVLHLTERLFLDHLHRLTGNKVQQYHRALAAVLLSRPWHVRRQAQQTARKLLSSLGGFKLAYGLLEELKTVLSSHKVLPFEALVTDTGEVTEAGKAYVPPRVLQEALCVISGVPGLEGGITGMEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFISRHLDQIIPRITTQNPLNQSSMNAMGSLSILSPDRVLPQLISTITTSVQNPALCQVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDKEAQIRRRLQELDSELEAALGLLDTILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKTPFLSLAACVMPPRLKALGTLVSHVTLRLLKPECALDESWCQEELSVAVKRAVTLLHSHTITSRAGKGEPDAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEERMAQILQILTVHAQLRASPSNPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASEALTTLCASSSGEDGCAFAEQEEVDVLLCALLSPCANVRDTVLRGLLELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSTMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQCLDSSQVKPLFQFFVPDALNDRNPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALATPSQQVQESVANCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSPKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRFIGNESRGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVNITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFMELLNGIRVMEDPGVRDTMLQALRFVIQGAGAKVDVVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSTVLQQYLLADVSGIDWMVRHGRSLALSVAVSVAPGRLCVGKYGSDVQDMILSNAMADRIPIAVSGVRGMGFLMKHHIETGGGQLPAKLSSLFIKLSSVFITEDLLCSWPG", "length": 2573, "header": "tr|F1MZT7-1|A0AAA9SA20_BOVIN Computationally mapped isoform of Stalled ribosome sensor GCN1 OS=Bos taurus OX=9913 GN=GCN1 PE=3 SV=3 CANONICAL=A0AAA9SA20-1" }, "locus": { "chromosome": "17", "start_pos": 62556500, "end_pos": 62503393, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023117.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023117.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023117.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023117.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1350, "start_aa": "Thr", "end_pos": 1350, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1350", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536143", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536143", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "stalled ribosome sensor activity", "id": "GO:0170011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170011", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "protein kinase regulator activity", "id": "GO:0019887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "GCN2-mediated signaling", "id": "GO:0140469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140469", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "protein-RNA covalent cross-linking repair", "id": "GO:0160127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160127", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1489, "end_pos": 1491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2202, "end_pos": 2204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2244, "end_pos": 2246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2305, "end_pos": 2307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 720, "end_pos": 722, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA20" }, { "id": "SM01349", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01349" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TOG", "eco_id": "ECO_0000259", "start_pos": 1365, "end_pos": 1598, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1350 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1489, "end_pos": 1491 }, { "start_pos": 193, "end_pos": 195 }, { "start_pos": 2202, "end_pos": 2204 }, { "start_pos": 2244, "end_pos": 2246 }, { "start_pos": 2305, "end_pos": 2307 }, { "start_pos": 720, "end_pos": 722 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7M4-1", "uniprot_ac": "A0AAA9S7M4", "uniprot_id": "A0AAA9S7M4_BOVIN", "mass": { "chemical_mass": 64607.0, "monoisotopic_mass": 64607.0 }, "refseq": {}, "gene_names": [ { "name": "LOC507615", "type": "recommended", "evidence": [ { "id": "A0AAA9S7M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ] } ], "protein_names": [ { "name": "Phylloquinone omega-hydroxylase CYP4F2-like", "type": "recommended", "evidence": [ { "id": "A0AAA9S7M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC507615", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7M4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7M4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039319", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039319", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20679", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20679", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507615", "url": "https://www.ncbi.nlm.nih.gov/gene/507615", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPG5", "url": "https://www.orthodb.org/?gene=A0A3S5ZPG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291:SF198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291:SF198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MRT7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPG5", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S736", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S736", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S736-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S736-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8J6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKDNTHLPFCAAWMFYPMSVLGGCCSSFRSLPIHTLGLRMLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNLVPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNASAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGVVCLIDIFGTHHNPSVWQDPEVYDPFRFDPENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ", "length": 563, "header": "tr|A0AAA9S7M4-1|A0AAA9S7M4_BOVIN Isoform 1 of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#A0A3Q1MRT7-1", "sequence": { "sequence": "MGLGSLAWGGKGHCSRQGGSREQAGLGDEWMMLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNLVPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNASAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGVVCLIDIFGTHHNPSVWQDPEVYDPFRFDPENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ", "length": 554, "header": "tr|A0A3Q1MRT7-1|A0AAA9S7M4_BOVIN Computationally mapped isoform of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "locus": { "chromosome": "7", "start_pos": 7426760, "end_pos": 7408158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067632.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067632.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072588.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072588.2" } ] } }, { "isoform_ac": "A0A3S5ZPG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#A0A3S5ZPG5-1", "sequence": { "sequence": "MEHPDGPDASLGASSSSRWAAYGVPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNASAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGVVCLIDIFGTHHNPSVWQDPEVYDPFRFDPENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ", "length": 480, "header": "tr|A0A3S5ZPG5-1|A0AAA9S7M4_BOVIN Computationally mapped isoform of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "locus": { "chromosome": "7", "start_pos": 7424619, "end_pos": 7408158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020890.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020890.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020890.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020890.4" } ] } }, { "isoform_ac": "A0AAA9S736-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#A0AAA9S736-1", "sequence": { "sequence": "MLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNLIQSWKEGLLYTQGLAGTYGDACCWWVGPWHVVIYIIHPTCIKPVLFAPAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGVVCLIDIFGTHHNPSVWQDPEVYDPFRFDPENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ", "length": 523, "header": "tr|A0AAA9S736-1|A0AAA9S736_BOVIN Computationally mapped isoform of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "locus": { "chromosome": "7", "start_pos": 7426411, "end_pos": 7408158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110343.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110343.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079721.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079721.1" } ] } }, { "isoform_ac": "A0AAA9S7M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#A0AAA9S7M4-1", "sequence": { "sequence": "MSKDNTHLPFCAAWMFYPMSVLGGCCSSFRSLPIHTLGLRMLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNLVPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNASAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGVVCLIDIFGTHHNPSVWQDPEVYDPFRFDPENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ", "length": 563, "header": "tr|A0AAA9S7M4-1|A0AAA9S7M4_BOVIN Isoform 1 of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "locus": { "chromosome": "7", "start_pos": 7429946, "end_pos": 7408158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095340.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095340.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081239.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081239.1" } ] } }, { "isoform_ac": "A0AAA9T2S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#A0AAA9T2S0-1", "sequence": { "sequence": "MLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNLVPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNASAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGLPLPLRPRKHQREVTSGFYSLLSRSQELHWADIRHD", "length": 453, "header": "tr|A0AAA9T2S0-1|A0AAA9T2S0_BOVIN Computationally mapped isoform of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "locus": { "chromosome": "7", "start_pos": 7426411, "end_pos": 7408300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121410.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121410.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090747.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090747.1" } ] } }, { "isoform_ac": "A0AAA9T8J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4/entry#A0AAA9T8J6-1", "sequence": { "sequence": "MSPHCSTLAWKNPMDRGTWMLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNLVPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNASAAIAPKDMQFYGTLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMHAKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQEKPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENIDDFLKAKAKTKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEWDDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPKGVVCLIDIFGTHHNPSVWQDPEVYDPFRFDPENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ", "length": 542, "header": "tr|A0AAA9T8J6-1|A0AAA9T8J6_BOVIN Computationally mapped isoform of Phylloquinone omega-hydroxylase CYP4F2-like OS=Bos taurus OX=9913 GN=LOC507615 PE=3 SV=1 CANONICAL=A0AAA9S7M4-1" }, "locus": { "chromosome": "7", "start_pos": 7432869, "end_pos": 7408158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097484.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097484.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092192.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092192.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "small molecule metabolic process", "id": "GO:0044281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7D5-1", "uniprot_ac": "A0AAA9S7D5", "uniprot_id": "A0AAA9S7D5_BOVIN", "mass": { "chemical_mass": 80694.0, "monoisotopic_mass": 80694.0 }, "refseq": {}, "gene_names": [ { "name": "TARS2", "type": "recommended", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ] } ], "protein_names": [ { "name": "Probable threonine--tRNA ligase, cytoplasmic", "type": "recommended", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.3", "type": "synonym", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#names_and_taxonomy" } ] }, { "name": "Threonine--tRNA ligase, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#names_and_taxonomy" } ] }, { "name": "Threonyl-tRNA synthetase-like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#names_and_taxonomy" } ] }, { "name": "Threonyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT2#function" }, { "database": "UniProtKB", "id": "ARBA00058633", "url": "https://www.uniprot.org/uniprotkb/ARBA00058633#function" }, { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5#function" }, { "database": "UniProtKB", "id": "A0AAA9SG64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG64#function" }, { "database": "UniProtKB", "id": "F1MX06", "url": "https://www.uniprot.org/uniprotkb/F1MX06#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TARS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5", "locus": { "chromosome": "3", "start_pos": 20190884, "end_pos": 20203830, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003799", "url": "https://www.ensembl.org/id/ENSBTAG00000003799" } ] } } ], "crossref": [ { "id": "A0AAA9S7D5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003799", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00771", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00771", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00860", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00860", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01667", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01667", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQT2", "url": "https://www.orthodb.org/?gene=A0A3Q1LQT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MX06", "url": "https://www.orthodb.org/?gene=F1MX06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11451", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11451", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11451:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11451:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00587", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00587", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02824", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02824", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "24624", "url": "https://www.rhea-db.org/rhea/24624", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQT2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX06", "url": "https://www.uniprot.org/uniprotkb/F1MX06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX06-1", "url": "https://www.uniprot.org/uniprotkb/F1MX06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDNITIGNLRTNTNHPHPQAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKDNPFKLRLIEEKVTGPTATVYGCGMLVDLCRGPHLRHTGQIGGLKLLSNSSSVWKFPDAPETLQRVSGISFPTAEELRAWEEWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIKAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGQLGALERPVLIHRAVLGSVERMLGVLAESCGGKWPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 716, "header": "tr|A0AAA9S7D5-1|A0AAA9S7D5_BOVIN Isoform 1 of Probable threonine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=1 CANONICAL=A0AAA9S7D5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#A0A3Q1LQT2-1", "sequence": { "sequence": "MGLYQRCRRLRFPGLHACGLHTAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKDNPFKLRLIEEKVTGPTATVYGCGMLVDLCRGPHLRHTGQIGGLKLLSNSSSVWKFPDAPETLQRVSGISFPTAEELRAWEEWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIKAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 684, "header": "tr|A0A3Q1LQT2-1|A0A3Q1LQT2_BOVIN Computationally mapped isoform of Threonine--tRNA ligase, mitochondrial OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=1 CANONICAL=A0AAA9S7D5-1" }, "locus": { "chromosome": "3", "start_pos": 20202497, "end_pos": 20191200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070315.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070315.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059467.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059467.1" } ] } }, { "isoform_ac": "A0AAA9S7D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#A0AAA9S7D5-1", "sequence": { "sequence": "MLDNITIGNLRTNTNHPHPQAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKDNPFKLRLIEEKVTGPTATVYGCGMLVDLCRGPHLRHTGQIGGLKLLSNSSSVWKFPDAPETLQRVSGISFPTAEELRAWEEWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIKAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGQLGALERPVLIHRAVLGSVERMLGVLAESCGGKWPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 716, "header": "tr|A0AAA9S7D5-1|A0AAA9S7D5_BOVIN Isoform 1 of Probable threonine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=1 CANONICAL=A0AAA9S7D5-1" }, "locus": { "chromosome": "3", "start_pos": 20203791, "end_pos": 20191200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111135.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111135.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078078.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078078.1" } ] } }, { "isoform_ac": "A0AAA9SG64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#A0AAA9SG64-1", "sequence": { "sequence": "MGLYQRCRRLRFPGLHACGLHTAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKDNPFKLRLIEEKVTGPTATVYGCGMLVDLCRGPHLRHTGQIGGLKLLSAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGQLGALERPVLIHRAVLGSVERMLGVLAESCGGKWPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 636, "header": "tr|A0AAA9SG64-1|A0AAA9S7D5_BOVIN Computationally mapped isoform of Probable threonine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=1 CANONICAL=A0AAA9S7D5-1" }, "locus": { "chromosome": "3", "start_pos": 20202497, "end_pos": 20191200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102468.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102468.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084362.1" } ] } }, { "isoform_ac": "A0AAA9SJ14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#A0AAA9SJ14-1", "sequence": { "sequence": "MGLYQRCRRLRFPGLHACGLHTAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGQLGALERPVLIHRAVLGSVERMLGVLAESCGGKWPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 588, "header": "tr|A0AAA9SJ14-1|A0AAA9S7D5_BOVIN Computationally mapped isoform of Probable threonine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=1 CANONICAL=A0AAA9S7D5-1" }, "locus": { "chromosome": "3", "start_pos": 20202497, "end_pos": 20191200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091350.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091350.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083791.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083791.1" } ] } }, { "isoform_ac": "A0AAA9SNC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#A0AAA9SNC5-1", "sequence": { "sequence": "MGLYQRCRRLRFPGLHACGLHTAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKNSSSVWKFPDAPETLQRVSGISFPTAEELRAWEEWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIKAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGQLGALERPVLIHRAVLGSVERMLGVLAESCGGKWPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 670, "header": "tr|A0AAA9SNC5-1|A0AAA9SNC5_BOVIN Computationally mapped isoform of threonine--tRNA ligase OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=1 CANONICAL=A0AAA9S7D5-1" }, "locus": { "chromosome": "3", "start_pos": 20202497, "end_pos": 20191200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122733.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122733.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086844.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086844.1" } ] } }, { "isoform_ac": "F1MX06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5/entry#F1MX06-1", "sequence": { "sequence": "MGLYQRCRRLRFPGLHACGLHTAAVPTPPHWLVERLGYFEELWTAQVKRLASMTQEEQRTIKISLPGGQKVDAVAWKTTPYQLAQQISSNLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSAQGKKVFWHSSTHVLGAAAEQLLGAVLCQGPSTECGFYHDFFLGKERTVKGSELPVLERFCQELTAAAQPFRRLEASRAQLRQLFKDNPFKLRLIEEKVTGPTATVYGCGMLVDLCRGPHLRHTGQIGGLKLLSVSHEDWVRLRFLCFHSSELRKGKNSSSVWKFPDAPETLQRVSGISFPTAEELRAWEEWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIKAEYTRRGFSEVKTPTLFSAKLWELSGHWEHYREDMFALQPPGLDRPSSSQSDHSASPHTDTLALKPMNCPAHCLMFAHRPRSWRELPLRLADFGALHRAEASGSLGGLTRLRCFQQDDAHIFCAPDQLEAEIRGCLDFLHSVYTILGFSFHMALSTRPSGFLGEPCLWDQAEQVLQQALEEFGAPWDISPGDGAFYGPKIDVHVRDALGRPHQCGTIQLDFQLPLRFDLQYKGQLGALERPVLIHRAVLGSVERMLGVLAESCGGKWPLWLSPFQVVVIPVGTEQEEYAREAQQSLRAAGLVGDLDADSGLTLSRRIRRAQLAHYNFQFVVGQREQSKRTVNIRTRDNRRLGERDLAEAVQRLLELQDTRVPNAEEIF", "length": 741, "header": "tr|F1MX06-1|F1MX06_BOVIN Computationally mapped isoform of Probable threonine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=TARS2 PE=3 SV=3 CANONICAL=A0AAA9S7D5-1" }, "locus": { "chromosome": "3", "start_pos": 20202497, "end_pos": 20191200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004948.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004948.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004948.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004948.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 225, "start_aa": "Thr", "end_pos": 225, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr225", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" }, { "name": "threonine-tRNA ligase activity", "id": "GO:0004829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" }, { "name": "aminoacyl-tRNA deacylase activity", "id": "GO:0002161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "threonyl-tRNA aminoacylation", "id": "GO:0006435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006435", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24624", "name": "", "equation": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S7D5-1", "A6QNM8-1", "Q3ZBV8-1" ], "evidence": [ { "id": "24624", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24624" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S7D5", "gene_name": "TARS2", "activity": [ { "ec_number": "6.1.1.3", "activity": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ] }, { "ec_number": "6.1.1.3", "activity": "", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ] } ] }, { "uniprot_ac": "A6QNM8", "gene_name": "TARS3", "activity": [ { "ec_number": "6.1.1.3", "activity": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A6QNM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM8" } ] }, { "ec_number": "6.1.1.3", "activity": "", "evidence": [ { "id": "A6QNM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM8" } ] } ] }, { "uniprot_ac": "Q3ZBV8", "gene_name": "TARS1", "activity": [ { "ec_number": "6.1.1.3", "activity": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ] }, { "ec_number": "6.1.1.3", "activity": "", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" }, { "id": "PS50862", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50862" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminoacyl-transfer RNA synthetases class-II family profile", "eco_id": "ECO_0000259", "start_pos": 326, "end_pos": 606, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" }, { "id": "PS51880", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51880" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TGS", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 119, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.3", "ec_name": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.1.1.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3" }, { "id": "6.1.1.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25, 225 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8A5-1", "uniprot_ac": "A0AAA9S8A5", "uniprot_id": "A0AAA9S8A5_BOVIN", "mass": { "chemical_mass": 104236.0, "monoisotopic_mass": 104236.0 }, "refseq": {}, "gene_names": [ { "name": "THBS3", "type": "recommended", "evidence": [ { "id": "A0AAA9S8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ] } ], "protein_names": [ { "name": "Thrombospondin-3", "type": "recommended", "evidence": [ { "id": "A0AAA9S8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.", "evidence": [ { "database": "UniProtKB", "id": "F1MHQ8", "url": "https://www.uniprot.org/uniprotkb/F1MHQ8#function" }, { "database": "UniProtKB", "id": "ARBA00056051", "url": "https://www.uniprot.org/uniprotkb/ARBA00056051#function" }, { "database": "UniProtKB", "id": "A0AAA9T5H2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5H2#function" }, { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5#function" }, { "database": "UniProtKB", "id": "A0AAA9SMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THBS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5", "locus": { "chromosome": "3", "start_pos": 15425517, "end_pos": 15414102, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000057", "url": "https://www.ensembl.org/id/ENSBTAG00000000057" } ] } } ], "crossref": [ { "id": "A0AAA9S8A5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8A5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000057", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000057", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16079", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16079", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024665", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024665", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MHQ8", "url": "https://www.orthodb.org/?gene=F1MHQ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10199:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10199:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05735", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05735", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5H2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5H2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5H2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHQ8", "url": "https://www.uniprot.org/uniprotkb/F1MHQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHQ8-1", "url": "https://www.uniprot.org/uniprotkb/F1MHQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPQPCAPWRIREPRWRGALNTRGRVIDLLTVGESRQMIAVVEKIRTALLTTGDIYLLSTFRLPPKQGGVLFGLYSRHDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSKPSPALQLYVDCKLGDQHAGLPALAPIPPAEVNGLEIRTGQKAYLRMQGFVESMKMILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCTDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTRVSGVGIDYARASKQVCNDVDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFVGNQSQGCFPARTCHSPAHSPCHAHAHCLFERNGAVSCACNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDACDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYVPPGPDNCRLVPNPNQKDSDGDGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGNTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV", "length": 955, "header": "tr|A0AAA9S8A5-1|A0AAA9S8A5_BOVIN Isoform 1 of Thrombospondin-3 OS=Bos taurus OX=9913 GN=THBS3 PE=3 SV=1 CANONICAL=A0AAA9S8A5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5/entry#A0AAA9S8A5-1", "sequence": { "sequence": "MDPQPCAPWRIREPRWRGALNTRGRVIDLLTVGESRQMIAVVEKIRTALLTTGDIYLLSTFRLPPKQGGVLFGLYSRHDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSKPSPALQLYVDCKLGDQHAGLPALAPIPPAEVNGLEIRTGQKAYLRMQGFVESMKMILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCTDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTRVSGVGIDYARASKQVCNDVDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFVGNQSQGCFPARTCHSPAHSPCHAHAHCLFERNGAVSCACNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDACDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYVPPGPDNCRLVPNPNQKDSDGDGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGNTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV", "length": 955, "header": "tr|A0AAA9S8A5-1|A0AAA9S8A5_BOVIN Isoform 1 of Thrombospondin-3 OS=Bos taurus OX=9913 GN=THBS3 PE=3 SV=1 CANONICAL=A0AAA9S8A5-1" }, "locus": { "chromosome": "3", "start_pos": 15425272, "end_pos": 15414253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113931.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113931.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079570.1" } ] } }, { "isoform_ac": "A0AAA9SMI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5/entry#A0AAA9SMI6-1", "sequence": { "sequence": "METQELRGALALLLLCTFVSASQDLQVIDLLTVGESRQMIAVVEKIRTALLTTGDIYLLSTFRLPPKQGGVLFGLYSRHDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSKPSPALQLYVDCKLGDQHAGLPALAPIPPAEVNGLEIRTGQKAYLRMQGFVESMKMILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCTDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTRVSGVGIDYARASKQVCNDVDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFVGNQSQGCFPARTCHSPAHSPCHAHAHCLFERNGAVSCACNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDACDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYVPPGPDNCRLVPNPNQKDSDGDGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGNTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIR", "length": 891, "header": "tr|A0AAA9SMI6-1|A0AAA9S8A5_BOVIN Computationally mapped isoform of Thrombospondin-3 OS=Bos taurus OX=9913 GN=THBS3 PE=3 SV=1 CANONICAL=A0AAA9S8A5-1" }, "locus": { "chromosome": "3", "start_pos": 15424059, "end_pos": 15415416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114356.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114356.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085154.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085154.1" } ] } }, { "isoform_ac": "A0AAA9SPX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5/entry#A0AAA9SPX9-1", "sequence": { "sequence": "METQELRGALALLLLCTFVSASQDLQVIDLLTVGESRQMIAVVEKIRTALLTTGDIYLLSTFRLPPKQGGVLFGLYSRHDNTRWLEASVVGKINKVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCTDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTRVSGVGIDYARASKQVCNDVDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFVGNQSQGCFPARTCHSPAHSPCHAHAHCLFERNGAVSCACNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDACDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYVPPGPDNCRLVPNPNQKDSDGDGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGNTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV", "length": 836, "header": "tr|A0AAA9SPX9-1|A0AAA9S8A5_BOVIN Computationally mapped isoform of Thrombospondin-3 OS=Bos taurus OX=9913 GN=THBS3 PE=3 SV=1 CANONICAL=A0AAA9S8A5-1" }, "locus": { "chromosome": "3", "start_pos": 15425272, "end_pos": 15415416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093705.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093705.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086043.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086043.1" } ] } }, { "isoform_ac": "A0AAA9T5H2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5/entry#A0AAA9T5H2-1", "sequence": { "sequence": "MDPQPCAPWRIREPRWRGALNTRGRVIDLLTVGESRQMIAVVEKIRTALLTTGDIYLLSTFRLPPKQGGVLFGLYSRHDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSKPSPALQLYVDCKLGDQHAGLPALAPIPPAEVNGLEIRTGQKAYLRMQGFVESMKMILGGSMARVGALSECPFQGDESIHSAVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCTDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTRVSGVGIDYARASKQGSFKCGPCRLGFVGNQSQGCFPARTCHSPAHSPCHAHAHCLFERNGAVSCACNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDACDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYVPPGPDNCRLVPNPNQKDSDGDGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGNTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV", "length": 929, "header": "tr|A0AAA9T5H2-1|A0AAA9T5H2_BOVIN Computationally mapped isoform of Thrombospondin 3 OS=Bos taurus OX=9913 GN=THBS3 PE=3 SV=1 CANONICAL=A0AAA9S8A5-1" }, "locus": { "chromosome": "3", "start_pos": 15425272, "end_pos": 15414253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111280.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111280.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093071.1" } ] } }, { "isoform_ac": "F1MHQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5/entry#F1MHQ8-1", "sequence": { "sequence": "METQELRGALALLLLCTFVSASQDLQVIDLLTVGESRQMIAVVEKIRTALLTTGDIYLLSTFRLPPKQGGVLFGLYSRHDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTALLRLRGPSKPSPALQLYVDCKLGDQHAGLPALAPIPPAEVNGLEIRTGQKAYLRMQGFVESMKMILGGSMARVGALSECPFQGDESIHSAGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCTDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTRVSGVGIDYARASKQVCNDVDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFVGNQSQGCFPARTCHSPAHSPCHAHAHCLFERNGAVSCACNVGWAGNGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDACDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYVPPGPDNCRLVPNPNQKDSDGDGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGNTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV", "length": 947, "header": "tr|F1MHQ8-1|F1MHQ8_BOVIN Computationally mapped isoform of Thrombospondin-3 OS=Bos taurus OX=9913 GN=THBS3 PE=3 SV=2 CANONICAL=A0AAA9S8A5-1" }, "locus": { "chromosome": "3", "start_pos": 15425272, "end_pos": 15415416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000063.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000063.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000063.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000063.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" }, { "start_pos": 936, "end_pos": 938, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 315, "end_pos": 353, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A5" }, { "id": "PS51236", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51236" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TSP C-terminal", "eco_id": "ECO_0000259", "start_pos": 726, "end_pos": 940, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 309, "end_pos": 311 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 643, "end_pos": 645 }, { "start_pos": 936, "end_pos": 938 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S794-1", "uniprot_ac": "A0AAA9S794", "uniprot_id": "A0AAA9S794_BOVIN", "mass": { "chemical_mass": 117603.0, "monoisotopic_mass": 117603.0 }, "refseq": {}, "gene_names": [ { "name": "LUZP1", "type": "recommended", "evidence": [ { "id": "A0AAA9S794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ] } ], "protein_names": [ { "name": "Leucine zipper protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LUZP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794", "locus": { "chromosome": "2", "start_pos": 129768958, "end_pos": 129665767, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009502", "url": "https://www.ensembl.org/id/ENSBTAG00000009502" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009502", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009502", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR050719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516426", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516426", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NVKKIMG", "url": "https://omabrowser.org/oma/group/NVKKIMG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LIG4", "url": "https://www.orthodb.org/?gene=A0A3Q1LIG4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKT0", "url": "https://www.orthodb.org/?gene=E1BKT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23166:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23166:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LIG4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIG4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S794-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKT0", "url": "https://www.uniprot.org/uniprotkb/E1BKT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKT0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEFTSYKDTASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEVEVLRQRVLRIEGKDEEIKKAEDLCQLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRIKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLLERNDLRIEDGISSPLPSKESRRKGALDYLKLAENETRNKSENEKNRNQEDNKVKDLTQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSGRGRHERTKLRGHGSEASAKHMARELSPQHKRERHCNRELTLNNENPLKNRQVSSPSFTNRKTAKASHAGAGADSGAQETRRTEDRFTAGSSQSEGKKSREQPPVLSRYPPAAQEHSKVWKGAPKPGTESGLKGKVEKATRTFSDNTHGSVSNDVSGRGDKASETSTEAPFGKRGQVPGSGSQITQAADAGSSKAVGALATSRRSSSEGLSKGKKATSGLEADTSFPSSKTPPLSKYPYSSRSQENILQGFSTPSKEGVEQPVAVVMEDSSQHEALRCRVTKSSGREKPDSDDDMDMVSLVTAKLVNTTITPEPEPPHQPQSREKAKSRGAVRASLFENDKDIGTENESGKAVRASANAMELPEANGSGAKSQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEAALEKQKSASKPGPNKVTSSITIYPSDSGSPRAAPGEAARERHTSTSNIQVGLPELASVSNHVSSPFELSIHKHDITLQLSEAERTGDGSLKNRPETVVSRSSIIIKPSDPVERNSHAPTVETIRWKSHSAPLEAGSPDARHITVRNAWKSRRDLNSSEDSPARVGRHVESPNPHTQRSSSDCSDPEQPGSYLSEQGTRRGGTSGEVPELASRRTQSSLAVSEVFTRRSRAGDAVPAEAWNHLAGTVGPASPPCPLLLPPSPFPSVLSSWFSSAPACVTRDAGDFGVRKH", "length": 1064, "header": "tr|A0AAA9S794-1|A0AAA9S794_BOVIN Isoform 1 of Leucine zipper protein 1 OS=Bos taurus OX=9913 GN=LUZP1 PE=4 SV=1 CANONICAL=A0AAA9S794-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794/entry#A0A3Q1LIG4-1", "sequence": { "sequence": "MAEFTSYKDTASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEVEVLRQRVLRIEGKDEEIKKAEDLCQLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRIKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLLERNDLRIEDGISSPLPSKESRRKGALDYLKLAENETRNKSENEKNRNQEDNKVKDLTQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSGRGRHERTKLRGHGSEASAKHMARELSPQHKRERHCNRELTLNNENPLKNRQVSSPSFTNRKTAKASHAGAGADSGAQETRRTEDRFTAGSSQSEGKKSREQPPVLSRYPPAAQEHSKVWKGAPKPGTESGLKGKVEKATRTFSDNTHGSVSNDVSGRGDKASETSTEAPFGKRGQVPGSGSQITQAADAGSSKAVGALATSRRSSSEGLSKGKKATSGLEADTSFPSSKTPPLSKYPYSSRSQENILQGFSTPSKEGVEQPVAVVMEDSSQHEALRCRVTKSSGREKPDSDDDMDMVSLVTAKLVNTTITPEPEPPHQPQSREKAKSRGAVRASLFENDKDIGTENESGKAVRASANAMELPEANGSGAKSQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEAALEKQKSASKPGPNKVTSSITIYPSDSGSPRAAPGEAARERHTSTSNIQVGLPELASVSNHVSSPFELSIHKHDITLQLSEAERTGDGSLKNRPETVVSRSSIIIKPSDPVERNSHAPTVETIRWKSHSAPLEAGSPDARHITVRNAWKSRRDLNSSEDSPARGTRRGGTSGEVPELASRRTQSSLAVSEVFTRRSRAGDAVPAEAWNHLAGTEEGDDCTLSVYRRLHNSLERSELSVTQGPPEPGRTRAEQRLRPTRPCAEDN", "length": 1039, "header": "tr|A0A3Q1LIG4-1|A0AAA9S794_BOVIN Computationally mapped isoform of Leucine zipper protein 1 OS=Bos taurus OX=9913 GN=LUZP1 PE=4 SV=1 CANONICAL=A0AAA9S794-1" }, "locus": { "chromosome": "2", "start_pos": 129764690, "end_pos": 129759821, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078568.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078568.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058819.1" } ] } }, { "isoform_ac": "A0AAA9S794-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794/entry#A0AAA9S794-1", "sequence": { "sequence": "MAEFTSYKDTASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEVEVLRQRVLRIEGKDEEIKKAEDLCQLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRIKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLLERNDLRIEDGISSPLPSKESRRKGALDYLKLAENETRNKSENEKNRNQEDNKVKDLTQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSGRGRHERTKLRGHGSEASAKHMARELSPQHKRERHCNRELTLNNENPLKNRQVSSPSFTNRKTAKASHAGAGADSGAQETRRTEDRFTAGSSQSEGKKSREQPPVLSRYPPAAQEHSKVWKGAPKPGTESGLKGKVEKATRTFSDNTHGSVSNDVSGRGDKASETSTEAPFGKRGQVPGSGSQITQAADAGSSKAVGALATSRRSSSEGLSKGKKATSGLEADTSFPSSKTPPLSKYPYSSRSQENILQGFSTPSKEGVEQPVAVVMEDSSQHEALRCRVTKSSGREKPDSDDDMDMVSLVTAKLVNTTITPEPEPPHQPQSREKAKSRGAVRASLFENDKDIGTENESGKAVRASANAMELPEANGSGAKSQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEAALEKQKSASKPGPNKVTSSITIYPSDSGSPRAAPGEAARERHTSTSNIQVGLPELASVSNHVSSPFELSIHKHDITLQLSEAERTGDGSLKNRPETVVSRSSIIIKPSDPVERNSHAPTVETIRWKSHSAPLEAGSPDARHITVRNAWKSRRDLNSSEDSPARVGRHVESPNPHTQRSSSDCSDPEQPGSYLSEQGTRRGGTSGEVPELASRRTQSSLAVSEVFTRRSRAGDAVPAEAWNHLAGTVGPASPPCPLLLPPSPFPSVLSSWFSSAPACVTRDAGDFGVRKH", "length": 1064, "header": "tr|A0AAA9S794-1|A0AAA9S794_BOVIN Isoform 1 of Leucine zipper protein 1 OS=Bos taurus OX=9913 GN=LUZP1 PE=4 SV=1 CANONICAL=A0AAA9S794-1" }, "locus": { "chromosome": "2", "start_pos": 129768693, "end_pos": 129765502, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094990.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094990.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084148.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084148.1" } ] } }, { "isoform_ac": "E1BKT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794/entry#E1BKT0-1", "sequence": { "sequence": "MAEFTSYKDTASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEVEVLRQRVLRIEGKDEEIKKAEDLCQLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRIKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLLERNDLRIEDGISSPLPSKESRRKGALDYLKLAENETRNKSENEKNRNQEDNKVKDLTQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSGRGRHERTKLRGHGSEASAKHMARELSPQHKRERHCNRELTLNNENPLKNRQVSSPSFTNRKTAKASHAGAGADSGAQETRRTEDRFTAGSSQSEGKKSREQPPVLSRYPPAAQEHSKVWKGAPKPGTESGLKGKVEKATRTFSDNTHGSVSNDVSGRGDKASETSTEAPFGKRGQVPGSGSQITQAADAGSSKAVGALATSRRSSSEGLSKGKKATSGLEADTSFPSSKTPPLSKYPYSSRSQENILQGFSTPSKEGVEQPVAVVMEDSSQHEALRCRVTKSSGREKPDSDDDMDMVSLVTAKLVNTTITPEPEPPHQPQSREKAKSRGAVRASLFENDKDIGTENESGKAVRASANAMELPEANGSGAKSQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEAALEKQKSASKPGPNKVTSSITIYPSDSGSPRAAPGEAARERHTSTSNIQVGLPELASVSNHVSSPFELSIHKHDITLQLSEAERTGDGSLKNRPETVVSRSSIIIKPSDPVERNSHAPTVETIRWKSHSAPLEAGSPDARHITVRNAWKSRRDLNSSEDSPARVGRHVESPNPHTQRSSSDCSDPEQPGSYLSEQGTRRGGTSGEVPELASRRTQSSLAVSEVFTRRSRAGDAVPAEAWNHLAGT", "length": 1020, "header": "tr|E1BKT0-1|A0AAA9S794_BOVIN Computationally mapped isoform of Leucine zipper protein 1 OS=Bos taurus OX=9913 GN=LUZP1 PE=4 SV=4 CANONICAL=A0AAA9S794-1" }, "locus": { "chromosome": "2", "start_pos": 129762880, "end_pos": 129759821, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012504.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012504.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012504.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012504.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516426", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516426", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I8J7-1", "protein_name": "Leucine zipper protein 1 isoform X1", "gene_name": "Luzp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADMASYKDAASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQEKVIQAEGSNSSMLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIEWLQKRMADLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKLIKELTQKLEQNKKMSRDHTRNASTLLERNDLRIEDGISSTLPSKELRRKGSLDYLKQVENETRDKSENEKNQNQEDNKVKDLNQEIQKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNKNKILASQLEEIKLQVKKQKELGNGDIEGEDAFLLGRGRHERTKLRGHGGEASVSRHIPRELSPQHKRERIRNREFALNNENYSLSNKQASSIFTNRRAAKASNMGVGADNGSQETKRAEDRFLPGSSQSEGKKCREQPSVLSRYPPAAQEHNKVWKGTLKPGTESGLKGKVEKTTRTFSDSTHGPVPNDTMGRGDKTSEISEAHYGKRGQVPGNGSQVTQAAESGCSKATGALSSSQRASSEGISKSKRAANGLEADANFPNSKAPILSKYPYSSRSQENIPQGFSVPNKEGLDQSVAVVMEDSSQHEALRCRVIKSSGKEKPDSDDDLDIESLVTAKLVNTTITPEPEPKQQPNSREKVKSRGPRTALFENDKNAATENESMKSTRASSSAVEFPDANGVGAKNQRLFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQRSTSNPVPSKVTSSITIYPSESSGPRAVQGEAPRERHTSTSNIQVGHPELTSVSNHVNSPLELSIHKHDITLQLTEAERMGDGSPKNRPETVVSRSSILIKPSDSVERNSHAPQAETVRWKSHNASSEVGSSDTRHVTVRNAWKSKRDFKCSEDVPTRVGRHMESTNAYTQRSSTDFLELEQPRSLPSEQGTRKVGDAGDAPELSSRRTQSSLTASEVITRRNRIGDAITATTWNHSASLEEGEDGTSVTSRRMHNTLEHSELPGKQGLPEPGIWAEERLQPARPYAEED", "length": 1069 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8N7UVR0-1", "protein_name": "Leucine zipper protein 1", "gene_name": "luzp1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTDTTNRHLRHKLQSLGRRLDELEEAKGKLQKAEDELLDIQDKIIQAEGSNSSLLTDVETMRKRLLKIEGKDEEVRKAEDLCREVREKLDQEEKLTKDFKVDIERLQRRMTELEKLEEAFGKSKSDCTQLCLSLNEEKNLTKKLAAELDALKARVKEVDASEGRLDKAEKSLTAEMEKLKSLTQTFMNERKRLLDKQREDDKIILRLTEKLERQKNKVGTTDHSRTDSRDLRIEDELSSGLTCKLARKKSLDYLKHSDDFDLRNESENEKNCLQGQEDNKVKDLSQEVERLKNRLKQMELVEEDLRNMESKNTELIEKYQQERNRSQALHDQVEQMRMELNVCSTSNGNSAITSTTKVLENGKAENEEFNVRGGFRQDKPKFLNRSPASSEQVTSKYKSRDSSPQQRRETKLRNKDLCHSRESSPKTVRRTLGPAHNVRKGQKTGASNTSDNGTRDGKKEEKNASASSCALSESKKVSVLSRYPPAVNDQRSWRPSVKQNDNDGKKSRVEKLSKCPGSDNESSNSDGTHFNSARATIVASPEKGLTEPESLDQDTSAVLSLSKANGSYTAYRSHVSPSFLTDHGSDGHSSASETESTGSRRSVGEQSDPLVSSTSGRTSKYTRYSRLQDSYSDASSKSPFSEEQQRPLTMEEEAQETAHSSSGIEVRRVCSPRESLQSKAVIKQAIVEIDRKEVMSGGTTEALTTSGKPKISTKPVLTSKMTSSITFYPNDPSSSRTSSRSSSLSSEPPSKERHTSTSNIVIGPSSEHRGSISIPYEISIPKSELTLRQSETDTDFSEPHSYLETAPLEATLLSQNSFSLQSSDASDFNNDIESGFESSSSSTTVTSWRSHAHNHLSYDDSLPEMRNITVRSTWKSRGAASVDESVRALRQDGSEDESESSTTWRAYRATTVLDTPANSSIGANCANKPSPAEVYMRRINNSASSVPEPGRRNKKTPSPERAIAHEPVSAQQLQPRVRKQPLSVDDRDPALSSWRRQPAGDLDPYDRPGSRGAWSSRNRTADGSRSWSNRHLDN", "length": 1034 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0YPS1-1", "protein_name": "Leucine zipper protein 1", "gene_name": "LUZP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEFTGYKETSNRHLRFKLQSLSRRLDELEEATKNLQKAEDELLELQDKVIQAEGSNSSMLADIEALRKRVLKIEGKDEEIKKAEELCRLMKEKLEEEESLTRELKSEIEHLQKRMAELEKLEEAFGRSKNDCTQLCLSLNEERNLTKKISTELEILRVKVKELEASEERMDKTEQSLTGELEKLKSLALSFISERKHFNEREKQNEKIIQELTLKLEQNNKLNRADQTRNASNLLERSSNNLLDRNDLRIEDDLTSALPSKETRRKGSVDYLKHVENETRNKSENQKNKNQEDNKVKDLTQEIERLKTQIKRFESLEEELKKMRAKNNDLQDSYLSEQNKNKLLTGELEEIKMQIKKQKDLENGEVENEDTSFSGRGKHDRAKYRVVAADFTAAKHKPREVSPQQRRERVRNRDFSFSNDSSSHGGKQTPSPSLMSRKAGKTSGAAALADAAATDTKKLEEKCLVSTFSSGQKEASFTQNEGKRPKEQPSVLSRYPPAAHEQKSWKTPSKPVSDLRSKAEKPSQATRGSCQSGADTRDEKSSRGESVASLAEKLKTNQGEVSDAVGDTQQSRGHCASANGVATAYRCHISPAESDPVGSKAEAGNASTASHRQPLEGRTKRAVISQEKELIDVSLESVKASPLTKRSHRSRSQEDILQILKEDAEQSAAAGHVNASLKAGSKTVQSSHEKLNSDEEAGRSKKANTQSDFETRKKANSKQFSNSRGVFRASLFENDKSTAHDEDSSKCIKPSDADTGGLKSRRSFSPREALRSKAIIKPAIVEKDMKAIMGGAVTETESEKQKSVIKAVTNKMTSSITIFPSEPTVPRPSTDTAGKERHITTSNIRVAPNEPSPITNSLPQPFEVSVNRSALKLSETDRSGDAVLRSRTETVVSRSSIVIKTSEPPERSGELPLDTASSRSHGSPDSISSETKHVTLRSSWRTRQGLPSLEDSQIKVEKNAASSPTNACRSSVDLSEMEGSSTRTNSLEQSSARSGATTNSWSAPEMGSRRTKSNLSASELLTRRSYTSDPTTASPWHRTTLPDESKDFVSSSRRKQYGSSEYLSQADTAGRRAVPPPEQLQDPTSNPNSPPGLQAEDQGASRVGRPTSRR", "length": 1111 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LNF8-1", "protein_name": "Leucine zipper protein 1", "gene_name": "LUZP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEFTSYKDTASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCQLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLLERNDLRIEDGISSLPSKESRRKGTLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYVREQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDALLSSKGRHERTKFRGHANEASVSKHTPRELSPQHKRERHRNREFAINNENYSLSNRQVSSPSFTSRRTAKASNTGAGVDSGTQETKRTEDRFTSGSSQSEGKKSREQPSVLSRYPPAAQEHSKVWKGTPRPGTEGGLKGKVEKTTRTFSDTSHGSVPNDISGRGDKTSDASAEALLSKRGQVPGNGSQITQAADSGSSKAIGALATSRRSSSEGLSKGKKAANGPESDTNSPNSKAPPLSKYSYSSRSQENILQGFSTPNKEGVDQPVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDMDTVSLVTAKLVNTTITPEPEPKQQPNSREKAKSRGGLRPSLFENDKDVGTENESGKPVRASTNAMELPEANGAGVKNQRPFSPREALRSKAIIKPVIIDKDVKKIMGGSGTEATLEKQKPTSRPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGPPDLTALSNHISSPFELSIHKHDFTLQFTEAERPGEGPLKNKPETVVSRSSIIIKPSEPVERNSHAPAAETIRWKSHSAPLEVGSSDARHVTVRNAWKSRRDLNSFEDPPTRIGKNVESTNAYTQRSSTDYSDLEQPGSYLSEQGTRRVGNSGDAPELSSRRTQSSLTVSEVLTRRNRVGDAVTAPAWNHSAGTEEGDDCTLGVYRRLHNSLERSELSAKQGLPEPGRARGEERLRPSRPCAEEN", "length": 1072 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q86V48-1", "protein_name": "Leucine zipper protein 1", "gene_name": "LUZP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIRWKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN", "length": 1076 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R4U7-1", "protein_name": "Leucine zipper protein 1", "gene_name": "Luzp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELTNYKDAASNRHLRFKLQSLSRRLDELEEATKNLQRAEDELLDLQDKVIQAEGSDSSTLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIERLQKRMVDLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKIIKELTQKLEQNKKMNRDHMRNASTFLERNDLRIEDGISSTLSSKESKRKGSLDYLKQVENETRDKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNRNRSLASQLEEIKLQVRKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGSEASVSKHTSRELSPQHKRERLRNREFALSNEHYSLSSKQASSPVFTNKRAAKASNMGMGTDSGTQETKRTEDRFAPGSSHSEGKRGREQPSVLSRYPPAAQEHTKVWKGAPKPGTESGLKGKVEKTTRTFSDSTHVSVPNDIVGKGDKTSDLSSEAHCGKRGQVPGHASQGTQAVESSCSKAIGALSSSQKASSEGLSKGKKTANGLAADANFSNSKAPILSKYPYSSRSQENILQGFSLPNKEGVDQPVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESFVTAKLVNTTITPEPEPKPQPNSREKVKSRGGTRTALFENDKNAAIENDSVKPTRPSSNAIEFPDANCAGVKNQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTSKSVTSKVTSSITIYPSDSSGPRAVPSEAPRERHTSTSNIQVGPPELTAISNHVSSPLELSIHKHDITLQLTEAERVGDGSPKNRAEMVVSRSSILIKPSESVEKNSHVPPAETIRWKSHSASSDSRHITVRNAWKSKRDLKCSEDPPTGIGRNMEATNAYTQRPCTDFLELEQPRSQPSEQGARRVGNSGDAPELSPRRTQSSLTASEVLTRRDRMGGAITAASCNHSSSMEEGEDSTFVTSRRIHNPLEHSELPGKQGLPEPEPVWTEERLHPAKPYAEED", "length": 1068 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ESV1-1", "protein_name": "Leucine zipper protein 1", "gene_name": "Luzp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADIANYKDAASNRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIDRLQKRMADLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLEKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKLIKELTQKLEQNKKINRDHMRNASTFLERNDLRIEDGISSTLPSKESRRKGSLDYLKQVENETRDKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNKNRSLASQLEEVKLQVKKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGGEVSVSKHTSREQSPQHKRERLRNRGFALNDEHCSLSNKQVSSPAFTNKRAAKASNMGVGPDSGTQETKRTEDRLAPGSSQSEGKKGREQPSVLSRYPPAAQDHTKVWRGNPKPGTESGLKGKVEKTTRTFSDSAHGSVPNDVVGKGDKTSDFSSEAHCGKRGQVPGHASQVTQVAESGCSKAIGALASSQRASSEGLSKGKKAANGLETDANFPHSKAPILSKYPYSSRSQENILQGFSVPNKEGVDHSVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESLVTAKLVNTTITPEPEPKLQPNSREKVKSRGGTRTPLFENDKNAAVENDSAKSMRSSSNAVEFPDANCAGVKNQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTPKSVTSKVTSSITIYPSDSSGPRAVPTEAPRERHTSTSNIQVGPPELTSVSNHISSPLELSIHKHDITLQLTEAERVGDGSPKNRAETVVSRSSILIKPSDSVERNSHAFPAETIRWKSHSTSSEVASSDTRHITVRNAWKSKRDLKCSEDPPTRIGRNVEATNAYTQRSSTDFLELEQPRSHPPEQGTRKVGNSGDAPELSSRRTQSSLTASEVLTRRNRIGDAVTAASWNHSSNVVSLTFLPSALICLTEDLGNTEGWEMLNLR", "length": 1051 }, "evidence": [ { "id": "A0AAA9S794", "url": "https://omabrowser.org/oma/group/A0AAA9S794/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein localization to actin cytoskeleton", "id": "GO:1903119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903119", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "negative regulation of cilium assembly", "id": "GO:1902018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "stress fiber assembly", "id": "GO:0043149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "apical constriction", "id": "GO:0003383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003383", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "regulation of protein complex stability", "id": "GO:0061635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "contractile ring contraction", "id": "GO:0036213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036213", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "spindle midzone", "id": "GO:0051233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051233", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "tight junction", "id": "GO:0070160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070160", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "CERF complex", "id": "GO:0090537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S794", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S794" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" }, { "start_pos": 714, "end_pos": 716, "annotation": "n_glycosylation_sequon" }, { "start_pos": 733, "end_pos": 735, "annotation": "n_glycosylation_sequon" }, { "start_pos": 930, "end_pos": 932, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 270, "end_pos": 272 }, { "start_pos": 274, "end_pos": 276 }, { "start_pos": 58, "end_pos": 60 }, { "start_pos": 674, "end_pos": 676 }, { "start_pos": 714, "end_pos": 716 }, { "start_pos": 733, "end_pos": 735 }, { "start_pos": 930, "end_pos": 932 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8T8-1", "uniprot_ac": "A0AAA9S8T8", "uniprot_id": "A0AAA9S8T8_BOVIN", "mass": { "chemical_mass": 51540.0, "monoisotopic_mass": 51540.0 }, "refseq": { "ac": "NP_001193091", "name": "interferon regulatory factor 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193091" }, "gene_names": [ { "name": "IRF4", "type": "recommended", "evidence": [ { "id": "A0AAA9S8T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ] }, { "name": "IRF4", "type": "synonym", "evidence": [ { "id": "NP_001193091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193091" } ] } ], "protein_names": [ { "name": "Interferon regulatory factor 4", "type": "recommended", "evidence": [ { "id": "A0AAA9S8T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#names_and_taxonomy" } ] }, { "name": "Lymphocyte-specific interferon regulatory factor", "type": "synonym", "evidence": [ { "id": "A0AAA9S8T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#names_and_taxonomy" } ] }, { "name": "NF-EM5", "type": "synonym", "evidence": [ { "id": "A0AAA9S8T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#names_and_taxonomy" } ] }, { "name": "interferon regulatory factor 4", "type": "synonym", "evidence": [ { "id": "NP_001193091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193091" } ] } ], "function": [ { "annotation": "Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB7#function" }, { "database": "UniProtKB", "id": "ARBA00060099", "url": "https://www.uniprot.org/uniprotkb/ARBA00060099#function" }, { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8#function" }, { "database": "UniProtKB", "id": "A0AAA9TTK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTK7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IRF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8", "locus": { "chromosome": "23", "start_pos": 52197501, "end_pos": 52217659, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002929", "url": "https://www.ensembl.org/id/ENSBTAG00000002929" } ] } } ], "crossref": [ { "id": "A0AAA9S8T8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8T8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002929", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002929", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00103", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00103", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506141", "url": "https://www.ncbi.nlm.nih.gov/gene/506141", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506141", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506141", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AKQLYYF", "url": "https://omabrowser.org/oma/group/AKQLYYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LM60", "url": "https://www.orthodb.org/?gene=A0A3Q1LM60", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BF88", "url": "https://www.orthodb.org/?gene=E1BF88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11949", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11949", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11949:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11949:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10401", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10401", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193091", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM60-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8T8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T985", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T985", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T985-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T985-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF88", "url": "https://www.uniprot.org/uniprotkb/E1BF88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF88-1", "url": "https://www.uniprot.org/uniprotkb/E1BF88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHVGGPEDFHRPPRHSSIQE", "length": 451, "header": "tr|A0AAA9S8T8-1|A0AAA9S8T8_BOVIN Isoform 1 of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LM60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0A3Q1LM60-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSGSATSWGQPRSPRAHLIRPPRLCTCGRAHSCRRSRTTAGHCQGSR", "length": 410, "header": "tr|A0A3Q1LM60-1|A0AAA9S8T8_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=2 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52207036, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086135.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086135.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057731.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057731.2" } ] } }, { "isoform_ac": "A0AAA9S8T8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9S8T8-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHVGGPEDFHRPPRHSSIQE", "length": 451, "header": "tr|A0AAA9S8T8-1|A0AAA9S8T8_BOVIN Isoform 1 of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52204941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095065.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095065.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080335.1" } ] } }, { "isoform_ac": "A0AAA9SMB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9SMB7-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHANPL", "length": 407, "header": "tr|A0AAA9SMB7-1|A0AAA9SMB7_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52202196, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122291.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122291.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086432.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086432.1" } ] } }, { "isoform_ac": "A0AAA9T985-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9T985-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHGRSGCPGSVSSTSISFYMKHASAGRIIIFHVI", "length": 435, "header": "tr|A0AAA9T985-1|A0AAA9T985_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52200826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095253.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095253.1" } ] } }, { "isoform_ac": "A0AAA9TTK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9TTK7-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHVGGPEDFHRPPRHSSIQE", "length": 415, "header": "tr|A0AAA9TTK7-1|A0AAA9TTK7_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52204941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131788.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131788.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100407.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100407.1" } ] } }, { "isoform_ac": "A0AAA9TVR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9TVR2-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSGAASVLLFPCDPGLCSVLVQPLSEVFSEVRGGNCELKAAAVQTGPSSQGFPRTFSSLQASQPTVSEN", "length": 432, "header": "tr|A0AAA9TVR2-1|A0AAA9TVR2_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52207914, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124885.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124885.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102440.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102440.1" } ] } }, { "isoform_ac": "A0AAA9TW90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9TW90-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHAWMTSARAHNTSEDGGEPCV", "length": 424, "header": "tr|A0AAA9TW90-1|A0AAA9TW90_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52205887, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099125.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099125.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100885.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100885.1" } ] } }, { "isoform_ac": "A0AAA9TZP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#A0AAA9TZP7-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHHPPKQHDCRDTLP", "length": 417, "header": "tr|A0AAA9TZP7-1|A0AAA9TZP7_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=1 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52197638, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109660.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109660.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102218.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102218.1" } ] } }, { "isoform_ac": "E1BF88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8/entry#E1BF88-1", "sequence": { "sequence": "MNLEGGSRGGEFGMSSVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMPMSHPYSMPTPYPSLPAQQVHNYMIPPHDRGWREFVPDQPHAEIPYQCPVTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYREVLVKELTTSSPEGCRISHGHTYDASSLDQVLFPYPEDSSQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLAICSDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRPLPRFQVTLCFGEEFPDPQRQRKLITAHPVSFLVAVSLPKIRSHMFS", "length": 423, "header": "tr|E1BF88-1|A0AAA9S8T8_BOVIN Computationally mapped isoform of Interferon regulatory factor 4 OS=Bos taurus OX=9913 GN=IRF4 PE=4 SV=3 CANONICAL=A0AAA9S8T8-1" }, "locus": { "chromosome": "23", "start_pos": 52217605, "end_pos": 52201548, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003812.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003812.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003812.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003812.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506141", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506141", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MCY3-1", "protein_name": "Interferon regulatory factor 4", "gene_name": "Irf4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNLEAGSRGAEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDTQMAMSHPYPMAAPYGSLPAQQVHNYMMPPHDRSWRDYAPDQSHPEIPYQCPVTFGPRSHHWQGPSCENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRDMLVKELTTSSPEGCRISHGHTYDVSNLDQVLFPYPEDNGQRKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPTPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLAKQLYYFAQQNSGHFLRGYDISEHISTPDYHRSLRHSSIQE", "length": 450 }, "evidence": [ { "id": "A0AAA9S8T8", "url": "https://omabrowser.org/oma/group/A0AAA9S8T8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M1NI50-1", "protein_name": "Interferon regulatory factor 4a", "gene_name": "irf4a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNLDGDCIMSVSCGNGKLRQWLIEQIDSGEYSGLVWENDEKTIFRIPWKHAGKQDYNRDEDAALFKAWALFKGKYREGLDKPDPPTWKTRLRCALNKSNDFDELVERSQLDISDPYKVYRIVPEGAKRGSKAISMEENTTHVTPLSYPMHSAYPALQPQMSGFMLPQERRDWREFGSDPPHTQTPHADLPYGQCPYPPSRSLPWHTAPCDNGYQISGSFYTYSPSESHPVAMDPSMRSAEAMAISDCRLHVSLFYRESLVKELTTSSPEGCRISSSASPGSPSSPSSPSEERLYGGAEPVLFPFPYPQSQRRGAEKLPNVLERGVLLWLSPDGLYAKRLCQGRVYWEGPLAPYADKPNKLEKEQTCKLMDTQQFLTELQGFIHHGRPMPRSQVILCFGDEFPDPQRQSKMITAQVEPMFARQLLYFASQTNGHYLRSYELQTPGSLPVEDYQRSLQHLTE", "length": 460 }, "evidence": [ { "id": "A0AAA9S8T8", "url": "https://omabrowser.org/oma/group/A0AAA9S8T8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Y4X6-1", "protein_name": "Interferon regulatory factor 4", "gene_name": "IRF4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNLEPGECGMNSVSCGNGKLRQWLIDQIDSGKYPGLVWENDEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQNSMEEQPLMNHPFPITSPYTSLPSQVPNYMVPHERNWREFAPEQPHPDIPYQCASVPFAARGHHWQGPGCENGCQVTGTFYACAPPESQTPGIPIEPSIRSGEALALSDCRLHICLYYREILVKEVTTSSPEGCRISQGQSYEVSSLEQVIFPYPEDNSQRKNIEKLLSHLERGVILWMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLAELQAFAHHGRPLPRYQVALCFGEEFPDPQRQRKLITAHVEPMFARQLYYFAQQNSGHLLRGYDLPELMTSPEDYHRSIRHSSIQE", "length": 445 }, "evidence": [ { "id": "A0AAA9S8T8", "url": "https://omabrowser.org/oma/group/A0AAA9S8T8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q15306-1", "protein_name": "Interferon regulatory factor 4", "gene_name": "IRF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHISNPEDYHRSIRHSSIQE", "length": 451 }, "evidence": [ { "id": "A0AAA9S8T8", "url": "https://omabrowser.org/oma/group/A0AAA9S8T8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64287-1", "protein_name": "Interferon regulatory factor 4", "gene_name": "Irf4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNLETGSRGSEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLDDTQMAMGHPYPMTAPYGSLPAQQVHNYMMPPHDRSWRDYAPDQSHPEIPYQCPVTFGPRGHHWQGPSCENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRDILVKELTTTSPEGCRISHGHTYDVSNLDQVLFPYPDDNGQRKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNTGHFLRGYELPEHVTTPDYHRSLRHSSIQE", "length": 450 }, "evidence": [ { "id": "A0AAA9S8T8", "url": "https://omabrowser.org/oma/group/A0AAA9S8T8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of interleukin-13 production", "id": "GO:0032736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032736", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of interleukin-2 production", "id": "GO:0032743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "defense response to protozoan", "id": "GO:0042832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "T-helper 17 cell lineage commitment", "id": "GO:0072540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of interleukin-10 production", "id": "GO:0032733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032733", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of interleukin-4 production", "id": "GO:0032753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032753", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "positive regulation of multicellular organismal process", "id": "GO:0051240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051240", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8T8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8T8" }, { "id": "PS51507", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51507" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IRF tryptophan pentad repeat", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 129, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8C8-1", "uniprot_ac": "A0AAA9S8C8", "uniprot_id": "A0AAA9S8C8_BOVIN", "mass": { "chemical_mass": 42986.0, "monoisotopic_mass": 42986.0 }, "refseq": { "ac": "XP_010809017", "name": "GPALPP motifs-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809017" }, "gene_names": [ { "name": "GPALPP1", "type": "recommended", "evidence": [ { "id": "A0AAA9S8C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8" } ] }, { "name": "GPALPP1", "type": "synonym", "evidence": [ { "id": "XP_010809017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809017" } ] } ], "protein_names": [ { "name": "GPALPP motifs-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S8C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#names_and_taxonomy" } ] }, { "name": "GPALPP motifs-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010809017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809017" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPALPP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8", "locus": { "chromosome": "12", "start_pos": 15191157, "end_pos": 15157012, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009416", "url": "https://www.ensembl.org/id/ENSBTAG00000009416" } ] } } ], "crossref": [ { "id": "A0AAA9S8C8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8C8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009416", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009416", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532698", "url": "https://www.ncbi.nlm.nih.gov/gene/532698", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NKAADFG", "url": "https://omabrowser.org/oma/group/NKAADFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPK0", "url": "https://www.orthodb.org/?gene=A0A3Q1LPK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXK5", "url": "https://www.orthodb.org/?gene=A0A3Q1LXK5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1ML86", "url": "https://www.orthodb.org/?gene=F1ML86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46370", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46370", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46370:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46370:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12572", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12572", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010809017", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809017", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXK5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXK5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1I6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5G8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5G8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML86", "url": "https://www.uniprot.org/uniprotkb/F1ML86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML86-1", "url": "https://www.uniprot.org/uniprotkb/F1ML86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSAGAGRVSLAFGGSLAARRGVLTRLGDTCVRLQCLTPRMARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKEMQEARKSFSKKDEEYIPSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKNKAAEDKNKPQERIPFDRDTDLKVHRFDEAQKKALIKKSRELNSRFSHGKGNMFL", "length": 389, "header": "tr|A0AAA9S8C8-1|A0AAA9S8C8_BOVIN Isoform 1 of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=1 CANONICAL=A0AAA9S8C8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#A0A3Q1LPK0-1", "sequence": { "sequence": "MSSAGAGRVSLAFGGSLAARRGVLTRLGDTCVRLQCLTPRMARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKVLLAAWRIFHCGVWNL", "length": 300, "header": "tr|A0A3Q1LPK0-1|A0AAA9S8C8_BOVIN Computationally mapped isoform of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=2 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15176207, "end_pos": 15157211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070166.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070166.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056856.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056856.2" } ] } }, { "isoform_ac": "A0A3Q1LXK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#A0A3Q1LXK5-1", "sequence": { "sequence": "MARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKVRGLVCSCISVHVGSILKNRRQNYSRVLFLSL", "length": 276, "header": "tr|A0A3Q1LXK5-1|A0AAA9S8C8_BOVIN Computationally mapped isoform of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=2 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15174280, "end_pos": 15157331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073801.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073801.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065513.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065513.2" } ] } }, { "isoform_ac": "A0AAA9S1I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#A0AAA9S1I6-1", "sequence": { "sequence": "MAAHSRTLAWKIPWMEEPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKEMQEARKSFSKKDEEYIPSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKNKAAEDKNKPQERIPFDRDTDLKVHRFDEAQKKALIKKSRELNSRFSHGKGNMFL", "length": 338, "header": "tr|A0AAA9S1I6-1|A0AAA9S8C8_BOVIN Computationally mapped isoform of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=1 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15185530, "end_pos": 15161924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120357.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120357.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079740.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079740.1" } ] } }, { "isoform_ac": "A0AAA9S8C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#A0AAA9S8C8-1", "sequence": { "sequence": "MSSAGAGRVSLAFGGSLAARRGVLTRLGDTCVRLQCLTPRMARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKEMQEARKSFSKKDEEYIPSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKNKAAEDKNKPQERIPFDRDTDLKVHRFDEAQKKALIKKSRELNSRFSHGKGNMFL", "length": 389, "header": "tr|A0AAA9S8C8-1|A0AAA9S8C8_BOVIN Isoform 1 of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=1 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15185530, "end_pos": 15157211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133465.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133465.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078408.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078408.1" } ] } }, { "isoform_ac": "A0AAA9SHQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#A0AAA9SHQ6-1", "sequence": { "sequence": "MSSAGAGRVSLAFGGSLAARRGVLTRLGDTCVRLQCLTPRMARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSERAAAAAAAAKSLQSCPTLCDPIDGSPPGSPIPGILQKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKEMQEARKSFSKKDEEYIPSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKNKAAEDKNKPQERIPFDRDTDLKVHRFDEAQKKALIKKSRELNSRFSHGKGNMFL", "length": 425, "header": "tr|A0AAA9SHQ6-1|A0AAA9SHQ6_BOVIN Computationally mapped isoform of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=1 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15185530, "end_pos": 15157211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107631.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107631.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082043.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082043.1" } ] } }, { "isoform_ac": "A0ABI0P5G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#A0ABI0P5G8-1", "sequence": { "sequence": "MARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKTSCSSLCEMQEARKSFSKKDEEYIPSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKNKAAEDKNKPQERIPFDRDTDLKVHRFDEAQKKALIKKSRELNSRFSHGKGNMFL", "length": 356, "header": "tr|A0ABI0P5G8-1|A0ABI0P5G8_BOVIN Computationally mapped isoform of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=1 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15185530, "end_pos": 15157331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154098.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154098.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106411.1" } ] } }, { "isoform_ac": "F1ML86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8/entry#F1ML86-1", "sequence": { "sequence": "MARDLIGPALPPGFKAGGSAEDEERDSSPVAGPALPPNYKSSSSESSDSDEDSSSLSEEGNQESEEDDTGPPARKLRRNQDDDDDDDDEGFFGPALPPGFKKQDDSPPRPMIGPALPPGFLKSTQKSDEGRSDPGQVSSDFNSEKETDSSEEEDIVGPMPAKGPVNSSVTAEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADGKSGDRSVWTDTPADRERKAKEMQEARKSFSKKDEEYIPSGRDKRLAEQVSSYNVLRTQW", "length": 283, "header": "tr|F1ML86-1|A0AAA9S8C8_BOVIN Computationally mapped isoform of GPALPP motifs-containing protein 1 OS=Bos taurus OX=9913 GN=GPALPP1 PE=4 SV=2 CANONICAL=A0AAA9S8C8-1" }, "locus": { "chromosome": "12", "start_pos": 15191087, "end_pos": 15157331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049172.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049172.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046105.2", "url": "https://www.ensembl.org/id/ENSBTAP00000046105.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287A3Y1-1", "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "GPALPP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARDLIGPALPPGFKASGSAEDEERDLSPVAGPALPPNYKSCSSESSDSDEDSSSLYEEGNQESEEDDTGATARKQRRHEEDDDDDDEGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDRSRDDPGQISSYFNSEKETDSSEEEDIVGPMPAKGPVNSSVSTEFEKRAQRMKEKLTKGDNDSSKPITRESWMTELPPEMKDFGLGPRTFKRKADDKSGDRSVWTDTPADRERKAKETQEARKSFSKKDEEHTLSGREKRLAEQVSSYNESKRSESLMDIHHKKLKNKAAEDKNKPQERIPFDRDKDLKVHRFDEAQKKALIKKSRELNTRFSHGKGNMFL", "length": 348 }, "evidence": [ { "id": "A0AAA9S8C8", "url": "https://omabrowser.org/oma/group/A0AAA9S8C8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H839-1", "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "Gpalpp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARDLIGPALPPGFKEHATTEDEEADLSPVAGPALPPNYRSSSSDSSDSDEDSSSLSEEGNQESEENDTGPTARKQRRNQDRDDDDDGFFGPALPPGFKKQDDSPPRPMIGPALPPGFIKSSQKSDRGREDPGQVSSFFNSEEAASSEDEDIVGPMPAKGPVNYSVTTEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKDFGLGPRTFKRRADDKSGDRSVWTDTPADRERKAKEIQETRKSLSKKDEENVLSGRDKRLAEQVSSYNESRRSESLMDIHHKKLKNKAAEDKNKHQERIPFDRDKDLKVNRFDEAQKKALIKKSQELNTRFSHGKGNMFL", "length": 346 }, "evidence": [ { "id": "A0AAA9S8C8", "url": "https://omabrowser.org/oma/group/A0AAA9S8C8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4V893-1", "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "Gpalpp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARDLIGPALPPGFKERATVEDQERDPSPVAGPALPPNYRSSSSDSSDSNEDSSSLSEEGNQESEEDDAGPTAKKQRRNQDRDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSPQKNDKGRENPGQVSPFFNSEEAESGEDEDIVGPMPAKGPVDYSVTAEFEKRAQRMKEKLTKGDDDSPKPVTRESWMTELPPEMKDFGLGPRTFKRRADDKSGDRSVWTDTPADRERKAKEIQEARKSLSKKDEENMLSGRDKRLAEQVSSYNESKRSESLMDIHHKRLKTKAAEDKNRHQERTPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL", "length": 348 }, "evidence": [ { "id": "A0AAA9S8C8", "url": "https://omabrowser.org/oma/group/A0AAA9S8C8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q69ZC8-1", "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "Gpalpp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARDLIGPALPPGFKEHATVEDEERDPSPVAGPALPPNYRSCSSDSSDSDEDSSSLSEEGNQESEEEDTGPNAKKQRRNQDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSPQKNDKGREDPGQVSSFFNSEEAESGEDEDIVGPMPAKGPVNYSVTTEFEKRAQRMKEKLTKGDDDSSKPITRESWMTELPPEMKEFGLGPRTFKRRADDKSGDRSVWTDTPADRERKAKEIQEARKSFSKKDEENILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKHQERIPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL", "length": 346 }, "evidence": [ { "id": "A0AAA9S8C8", "url": "https://omabrowser.org/oma/group/A0AAA9S8C8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IXQ4-1", "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "GPALPP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARDLIGPALPPGFKARGTAEDEERDPSPVAGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDSGPTARKQRKNQDDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTSGDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL", "length": 340 }, "evidence": [ { "id": "A0AAA9S8C8", "url": "https://omabrowser.org/oma/group/A0AAA9S8C8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VFF2-1", "protein_name": "DUF3752 domain-containing protein", "gene_name": "CG3641", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSDDNSSDSNSSSDERQRKRKLKKHSKDVDKSKKKKSKKHKKEKRRHKEKKRSKHEEEPPVPYTQPPHLINASPPDVATNNEDSFGPALPPHLRKTQQPELPEQSQPAPQPQAMIGPVLPSNLTREKSPTKEAEAEDDDDLAGTFGPLPNASQVALEERALALKLAALEGGGLGTSTDQDVREEWMLELPDVGLKSGLAALSNMKRTFYQGKERPDFSDRSSWTKTPQSEADAAASGPKSLSSKELEQMAQVKYEQQRDDEQESMAKRHKKKHKREESLVELHQKKLRKEQREKEKELAASGSKPERRPFSRDVDLKLNKIDKNQTKQIVDKAKILNTKFSRGQAKYL", "length": 349 }, "evidence": [ { "id": "A0AAA9S8C8", "url": "https://omabrowser.org/oma/group/A0AAA9S8C8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C8" }, { "id": "PF12572", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12572" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF3752", "eco_id": "ECO_0000259", "start_pos": 245, "end_pos": 381, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 317, "end_pos": 319 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7U5-1", "uniprot_ac": "A0AAA9S7U5", "uniprot_id": "A0AAA9S7U5_BOVIN", "mass": { "chemical_mass": 203966.0, "monoisotopic_mass": 203966.0 }, "refseq": { "ac": "XP_002699983", "name": "bromodomain and WD repeat-containing protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699983" }, "gene_names": [ { "name": "BRWD3", "type": "recommended", "evidence": [ { "id": "A0AAA9S7U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" } ] }, { "name": "BRWD3", "type": "synonym", "evidence": [ { "id": "XP_002699983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699983" } ] } ], "protein_names": [ { "name": "Bromodomain and WD repeat-containing protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9S7U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#names_and_taxonomy" } ] }, { "name": "bromodomain and WD repeat-containing protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002699983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699983" } ] } ], "function": [ { "annotation": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MJX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJX6#function" }, { "database": "UniProtKB", "id": "ARBA00055163", "url": "https://www.uniprot.org/uniprotkb/ARBA00055163#function" }, { "database": "UniProtKB", "id": "A0AAA9T754", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T754#function" }, { "database": "UniProtKB", "id": "A0AAA9TNA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA4#function" }, { "database": "UniProtKB", "id": "A0A3Q1M9P4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9P4#function" }, { "database": "UniProtKB", "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5#function" }, { "database": "UniProtKB", "id": "F1N1C9", "url": "https://www.uniprot.org/uniprotkb/F1N1C9#function" }, { "database": "UniProtKB", "id": "A0A3Q1LQD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQD7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRWD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5", "locus": { "chromosome": "X", "start_pos": 71854447, "end_pos": 71689424, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016230", "url": "https://www.ensembl.org/id/ENSBTAG00000016230" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016230", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016230", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05529", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05529", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534539", "url": "https://www.ncbi.nlm.nih.gov/gene/534539", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534539", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534539", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQD7", "url": "https://www.orthodb.org/?gene=A0A3Q1LQD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9P4", "url": "https://www.orthodb.org/?gene=A0A3Q1M9P4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJX6", "url": "https://www.orthodb.org/?gene=A0A3Q1MJX6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1C9", "url": "https://www.orthodb.org/?gene=F1N1C9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16266:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16266:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25313", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25313", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002699983", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699983", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9P4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9P4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T754", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T754", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T754-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T754-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C9", "url": "https://www.uniprot.org/uniprotkb/F1N1C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C9-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGREHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1801, "header": "tr|A0AAA9S7U5-1|A0AAA9S7U5_BOVIN Isoform 1 of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=1 CANONICAL=A0AAA9S7U5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#A0A3Q1LQD7-1", "sequence": { "sequence": "MHLLFGIDTHKKVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1753, "header": "tr|A0A3Q1LQD7-1|A0AAA9S7U5_BOVIN Computationally mapped isoform of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=2 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71703452, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086749.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086749.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062388.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062388.2" } ] } }, { "isoform_ac": "A0A3Q1M9P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#A0A3Q1M9P4-1", "sequence": { "sequence": "MSTRFIHVVIDGRFAFSHCKRQLFSLSPAFPISRIKEHKVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1697, "header": "tr|A0A3Q1M9P4-1|A0AAA9S7U5_BOVIN Computationally mapped isoform of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=2 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71740533, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072296.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072296.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065193.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065193.2" } ] } }, { "isoform_ac": "A0A3Q1MJX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#A0A3Q1MJX6-1", "sequence": { "sequence": "MNPYPRVNEVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1750, "header": "tr|A0A3Q1MJX6-1|A0AAA9S7U5_BOVIN Computationally mapped isoform of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=2 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71708819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079562.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079562.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071699.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071699.2" } ] } }, { "isoform_ac": "A0AAA9S7U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#A0AAA9S7U5-1", "sequence": { "sequence": "MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGREHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1801, "header": "tr|A0AAA9S7U5-1|A0AAA9S7U5_BOVIN Isoform 1 of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=1 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71701676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110175.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110175.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078213.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078213.1" } ] } }, { "isoform_ac": "A0AAA9T754-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#A0AAA9T754-1", "sequence": { "sequence": "MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGREHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1756, "header": "tr|A0AAA9T754-1|A0AAA9T754_BOVIN Computationally mapped isoform of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=1 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71701676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133804.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133804.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091650.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091650.1" } ] } }, { "isoform_ac": "A0AAA9TNA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#A0AAA9TNA4-1", "sequence": { "sequence": "MNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGGRGRGRGRGGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1658, "header": "tr|A0AAA9TNA4-1|A0AAA9TNA4_BOVIN Computationally mapped isoform of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=1 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71758523, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112179.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112179.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098748.1" } ] } }, { "isoform_ac": "F1N1C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5/entry#F1N1C9-1", "sequence": { "sequence": "MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGREHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFSHIFPSAAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFWQWHVKTMKFKDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFVWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDAPHFPINRSYSSNGALRNPDMDISASPNIGLRRSGQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNNGVSRVQEECRTVKGDIEISLYTVEKKKKPSYTTQRSDYQPSYGRSLRRTQRKRQHTYQTRSNIEHNSRASCQNSGVQEDSDSSSEEDETVGTSDASIEDPVIEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQATQKICSSSEEENLKSLEERQKKPKQTRKKKGGLVSMAGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKTYSVNLQKQPWNKMDLREQEFVKIVGIKYEIGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEELNSTDAEEDTEMVDLDSDGPGTSSGRRVKCRGRRQSLRFNPDAWRKQCKELLGLIYEREDSEPFRQPSDPLSYPGHQEHEGESSESVIPGQQQDSSLCEDYHDVIDTPMDFSTVKETLETGNYGSPLEFYKDVRQIFSNSKAYTSNKKSRIYSMTLRLSALFESRIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSNRAPSPKGKQKQMKLQPKNDQNTSVSYARNSTPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFSGYNRSGNSHDPGKAKSFRNRVLPIKQDHSIDGPLTNGDGREPRTGIKRRLLSASEEDEIMGREEKEKKETKEKSHLSSSESGELESSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQYANGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGASRGATRAKRARITDDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGRVRKMTEKARVSHLMGWNY", "length": 1786, "header": "tr|F1N1C9-1|F1N1C9_BOVIN Computationally mapped isoform of Bromodomain and WD repeat-containing protein 3 OS=Bos taurus OX=9913 GN=BRWD3 PE=4 SV=3 CANONICAL=A0AAA9S7U5-1" }, "locus": { "chromosome": "X", "start_pos": 71853443, "end_pos": 71701676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021597.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021597.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021597.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021597.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534539", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534539", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1262, "end_pos": 1264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1482, "end_pos": 1484, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1490, "end_pos": 1492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1527, "end_pos": 1529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U5" }, { "id": "PS50014", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bromo", "eco_id": "ECO_0000259", "start_pos": 1157, "end_pos": 1227, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 1262, "end_pos": 1264 }, { "start_pos": 145, "end_pos": 147 }, { "start_pos": 1482, "end_pos": 1484 }, { "start_pos": 1490, "end_pos": 1492 }, { "start_pos": 1527, "end_pos": 1529 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 674, "end_pos": 676 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8J7-1", "uniprot_ac": "A0AAA9S8J7", "uniprot_id": "A0AAA9S8J7_BOVIN", "mass": { "chemical_mass": 26423.0, "monoisotopic_mass": 26423.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101903900", "type": "recommended", "evidence": [ { "id": "A0AAA9S8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ] } ], "protein_names": [ { "name": "Serine/arginine-rich splicing factor 9", "type": "recommended", "evidence": [ { "id": "A0AAA9S8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7/entry#names_and_taxonomy" } ] }, { "name": "Splicing factor, arginine/serine-rich 9", "type": "synonym", "evidence": [ { "id": "A0AAA9S8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP2#function" }, { "database": "UniProtKB", "id": "ARBA00056632", "url": "https://www.uniprot.org/uniprotkb/ARBA00056632#function" }, { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101903900", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7", "locus": {} } ], "crossref": [ { "id": "A0AAA9S8J7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8J7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005584", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005584", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12598", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12598", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12768", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12768", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101903900", "url": "https://www.ncbi.nlm.nih.gov/gene/101903900", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034995", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034995", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101903900", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101903900", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RHPMLRH", "url": "https://omabrowser.org/oma/group/RHPMLRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23003:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23003:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LQP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8J7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FPQCCAAERLRARGDTRGGEGDGRIYVGNLPNDVREKDLEDLFYKYGHISEIELKNRHGLVPFAFVRFEDPRDAEDAVYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRSGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGMGMVEYLRKEDMEYALRKLDETKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHDFSPFRPY", "length": 230, "header": "tr|A0AAA9S8J7-1|A0AAA9S8J7_BOVIN Isoform 1 of Serine/arginine-rich splicing factor 9 OS=Bos taurus OX=9913 GN=LOC101903900 PE=3 SV=1 CANONICAL=A0AAA9S8J7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7/entry#A0A3Q1LQP2-1", "sequence": { "sequence": "MSGWEDERGGEGDGRIYVGNLPNDVREKDLEDLFYKYGHISEIELKNRHGLVPFAFVRFEDPRDAEDAVYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRSGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGMGMVEYLRKEDMEYALRKLDETKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHDFSPFRPY", "length": 221, "header": "tr|A0A3Q1LQP2-1|A0AAA9S8J7_BOVIN Computationally mapped isoform of Serine/arginine-rich splicing factor 9 OS=Bos taurus OX=9913 GN=LOC101903900 PE=3 SV=1 CANONICAL=A0AAA9S8J7-1" }, "locus": { "chromosome": "2", "start_pos": 118180902, "end_pos": 118180842, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007335.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007335.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062511.1" } ] } }, { "isoform_ac": "A0AAA9S8J7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7/entry#A0AAA9S8J7-1", "sequence": { "sequence": "FPQCCAAERLRARGDTRGGEGDGRIYVGNLPNDVREKDLEDLFYKYGHISEIELKNRHGLVPFAFVRFEDPRDAEDAVYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRSGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGMGMVEYLRKEDMEYALRKLDETKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHDFSPFRPY", "length": 230, "header": "tr|A0AAA9S8J7-1|A0AAA9S8J7_BOVIN Isoform 1 of Serine/arginine-rich splicing factor 9 OS=Bos taurus OX=9913 GN=LOC101903900 PE=3 SV=1 CANONICAL=A0AAA9S8J7-1" }, "locus": { "chromosome": "2", "start_pos": 118179365, "end_pos": 118178577, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122862.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122862.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081590.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081590.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101903900", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101903900", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2RVS6-1", "protein_name": "Serine/arginine-rich splicing factor SR34A", "gene_name": "SR34A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSGRFSRSIYVGNLPGDIREHEIEDIFYKYGRIVDIELKVPPRPPCYCFVEFEHSRDAEDAIKGRDGYNLDGCRLRVELAHGGRGQSSSDRRGGYGGGGSGYGGGGGGGGSARFGVSRHSEFRVIVRGLPSSASWQDLKDHMRKAGDVCFAEVTRDSDGTYGVVDYTNYDDMKYAIRKLDDTEFRNPWARGFIRVKKYESSRSRSRSPSRSRSRSRSRSRSRGRGRSHSRSRSLSRSKSPRKDLSKSPRRSLSRSISKSRSPSPDKKKSPPRAMSRSKSRSRSRSRSPSKSPPKVREGSV", "length": 300 }, "evidence": [ { "id": "A0AAA9S8J7", "url": "https://omabrowser.org/oma/group/A0AAA9S8J7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F1QVC6-1", "protein_name": "Serine/arginine-rich splicing factor 9", "gene_name": "srsf9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDGRIYVGNLPMDVQERDIEDLFFKYGKIRDIELKNNRSTIPFAFVRFEDPRDAEDAVFGRNGYGFGDCKLRVEYPRSSGSKFSGPAGGGGGGGPRGRFGPPTRRSEFRVIVTGLPPTGSWQDLKDHMREAGDVCFADVQRDGEGVVEFLRREDMEYALRRLDSTEFRSHQGETAYIRVMEERGTSWGRSRSRSRSRGRYTPPYQSRGSPPPRYRSPPRHMTRHSPPSRRPPLQHHSPPPRHYR", "length": 245 }, "evidence": [ { "id": "A0AAA9S8J7", "url": "https://omabrowser.org/oma/group/A0AAA9S8J7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J7" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 98, "start_aa": "Gly", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S710-1", "uniprot_ac": "A0AAA9S710", "uniprot_id": "A0AAA9S710_BOVIN", "mass": { "chemical_mass": 52388.0, "monoisotopic_mass": 52388.0 }, "refseq": { "ac": "XP_024851701", "name": "uncharacterized protein C9orf43 homolog isoform X6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851701" }, "gene_names": [ { "name": "C8H9orf43", "type": "recommended", "evidence": [ { "id": "A0AAA9S710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710" } ] }, { "name": "C8H9orf43", "type": "synonym", "evidence": [ { "id": "XP_024851701", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851701" } ] } ], "protein_names": [ { "name": "Chromosome 8 C9orf43 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9S710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C9orf43 homolog isoform X6", "type": "synonym", "evidence": [ { "id": "XP_024851701", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851701" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S710", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C8H9orf43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710", "locus": { "chromosome": "8", "start_pos": 102676729, "end_pos": 102658242, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009596", "url": "https://www.ensembl.org/id/ENSBTAG00000009596" } ] } } ], "crossref": [ { "id": "A0AAA9S710", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S710", "database": "AlphaFoldDB", "categories": [] }, { "id": "614006", "url": "https://www.ncbi.nlm.nih.gov/gene/614006", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR36130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36130:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36130:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15504", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15504", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851701", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851701", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S710", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S710-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATETASDTDDRVWWDMDLPDKSQWDETTCDLAVCQHPQCWATIRRIERGHPRLLDSSSKSFLDAEDKLPVLTIVNIADSCFPAKRVMCRCHLPGFTFTKARSLLSSKFDSKFEGRKDLPDRDLMNRADRSPKLSVLNLNETKLPCPQDVGNMDVIWIPEKHVSPAEEKHIICSQDGNMNRNKSPGKHKLELPGIMIPPPTPAYSHEQLSSESLPLWNQFDVLPQDLLKDLLLDKGKTILYPEMQTQLAMMKKKSPLEKSRPDSAISAKMYLSVHRLTLQKPALRYPEHLKKHYSNLKTDGHRKQQQQQQRKVKTATRKQEAKRRCKSEPGSHNTSHKHSGRKTLRGQESSKKQQQQMKTEGPTLKQDSTERLQTNVAKKSLDSSRSKKSPKLSQIEYTKKDIKTQMEILLEDQMRSPKSASSISWNPELKLLRILQATDEEDEETHPSGAQSEVSEV", "length": 458, "header": "tr|A0AAA9S710-1|A0AAA9S710_BOVIN Isoform 1 of Chromosome 8 C9orf43 homolog OS=Bos taurus OX=9913 GN=C8H9orf43 PE=4 SV=2 CANONICAL=A0AAA9S710-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S710-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S710/entry#A0AAA9S710-1", "sequence": { "sequence": "MATETASDTDDRVWWDMDLPDKSQWDETTCDLAVCQHPQCWATIRRIERGHPRLLDSSSKSFLDAEDKLPVLTIVNIADSCFPAKRVMCRCHLPGFTFTKARSLLSSKFDSKFEGRKDLPDRDLMNRADRSPKLSVLNLNETKLPCPQDVGNMDVIWIPEKHVSPAEEKHIICSQDGNMNRNKSPGKHKLELPGIMIPPPTPAYSHEQLSSESLPLWNQFDVLPQDLLKDLLLDKGKTILYPEMQTQLAMMKKKSPLEKSRPDSAISAKMYLSVHRLTLQKPALRYPEHLKKHYSNLKTDGHRKQQQQQQRKVKTATRKQEAKRRCKSEPGSHNTSHKHSGRKTLRGQESSKKQQQQMKTEGPTLKQDSTERLQTNVAKKSLDSSRSKKSPKLSQIEYTKKDIKTQMEILLEDQMRSPKSASSISWNPELKLLRILQATDEEDEETHPSGAQSEVSEV", "length": 458, "header": "tr|A0AAA9S710-1|A0AAA9S710_BOVIN Isoform 1 of Chromosome 8 C9orf43 homolog OS=Bos taurus OX=9913 GN=C8H9orf43 PE=4 SV=2 CANONICAL=A0AAA9S710-1" }, "locus": { "chromosome": "8", "start_pos": 102676270, "end_pos": 102659580, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116574.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116574.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077955.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077955.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 201, "start_aa": "Thr", "end_pos": 201, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr201", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 201 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 334, "end_pos": 336 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S954-1", "uniprot_ac": "A0AAA9S954", "uniprot_id": "A0AAA9S954_BOVIN", "mass": { "chemical_mass": 55904.0, "monoisotopic_mass": 55904.0 }, "refseq": { "ac": "NP_001179180", "name": "calcium/calmodulin-dependent protein kinase kinase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179180" }, "gene_names": [ { "name": "CAMKK1", "type": "recommended", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "name": "CAMKK1", "type": "synonym", "evidence": [ { "id": "NP_001179180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179180" } ] } ], "protein_names": [ { "name": "calcium/calmodulin-dependent protein kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.17", "type": "synonym", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954/entry#names_and_taxonomy" } ] }, { "name": "calcium/calmodulin-dependent protein kinase kinase 1", "type": "synonym", "evidence": [ { "id": "NP_001179180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179180" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAMKK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954", "locus": { "chromosome": "19", "start_pos": 24494920, "end_pos": 24523050, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007166", "url": "https://www.ensembl.org/id/ENSBTAG00000007166" } ] } } ], "crossref": [ { "id": "A0AAA9S954", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S954", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007166", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007166", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510260", "url": "https://www.ncbi.nlm.nih.gov/gene/510260", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510260", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510260", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MACGPCM", "url": "https://omabrowser.org/oma/group/MACGPCM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIP3", "url": "https://www.orthodb.org/?gene=E1BIP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43895", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43895", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43895:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43895:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-111932", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111932", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-442729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9619229", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9619229", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179180", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S954-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIP3", "url": "https://www.uniprot.org/uniprotkb/E1BIP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIP3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGGPAVCCQDPRAELVERVAAIDVTHLEETDGSPEPPRNCVDPPSRTRAASLIPSGPSRHPAVRPSLSTRKFSLQERPAGSCLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDARLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILALHRKIKNEAVVFPEEPKVSEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSMVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREARSMSAPGSLLSKDGFGEGGKSPELPGVQEDEAAS", "length": 505, "header": "tr|A0AAA9S954-1|A0AAA9S954_BOVIN Isoform 1 of calcium/calmodulin-dependent protein kinase OS=Bos taurus OX=9913 GN=CAMKK1 PE=4 SV=1 CANONICAL=A0AAA9S954-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S954-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954/entry#A0AAA9S954-1", "sequence": { "sequence": "MEGGPAVCCQDPRAELVERVAAIDVTHLEETDGSPEPPRNCVDPPSRTRAASLIPSGPSRHPAVRPSLSTRKFSLQERPAGSCLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDARLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILALHRKIKNEAVVFPEEPKVSEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSMVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREARSMSAPGSLLSKDGFGEGGKSPELPGVQEDEAAS", "length": 505, "header": "tr|A0AAA9S954-1|A0AAA9S954_BOVIN Isoform 1 of calcium/calmodulin-dependent protein kinase OS=Bos taurus OX=9913 GN=CAMKK1 PE=4 SV=1 CANONICAL=A0AAA9S954-1" }, "locus": { "chromosome": "19", "start_pos": 24515172, "end_pos": 24495317, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124509.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124509.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081817.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081817.1" } ] } }, { "isoform_ac": "E1BIP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954/entry#E1BIP3-1", "sequence": { "sequence": "MEGGPAVCCQDPRAELVERVAAIDVTHLEETDGSPEPPRNCVDPPSRTRAASLIPSGPSRHPAVRPSLSTRKFSLQERPAGSCLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALLSQTQDIQLESTSIPKPHATDRRDSGSVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDARLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILALHRKIKNEAVVFPEEPKVSEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSMVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREARSMSAPGSLLS", "length": 511, "header": "tr|E1BIP3-1|A0AAA9S954_BOVIN Computationally mapped isoform of calcium/calmodulin-dependent protein kinase OS=Bos taurus OX=9913 GN=CAMKK1 PE=4 SV=4 CANONICAL=A0AAA9S954-1" }, "locus": { "chromosome": "19", "start_pos": 24515172, "end_pos": 24497649, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009431.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009431.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009431.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009431.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:510260", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510260", "resource": "KEGG Pathway" }, { "id": "R-BTA-111932", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111932", "resource": "Reactome", "description": "CaMK IV-mediated phosphorylation of CREB" }, { "id": "R-BTA-442729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442729", "resource": "Reactome", "description": "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" }, { "id": "R-BTA-9619229", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9619229", "resource": "Reactome", "description": "Activation of RAC1 downstream of NMDARs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2BJ77-1", "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "camkk1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVMAMSSGPGGVRVERDPDSSQTAEMTDRMSVMSLGPDSSSSVLKNGMGVKKAQPKRPHLSGRKMSLQERGTYMSSRIARQPTIESKRVSISDSQDCIQLNQYKLKSEIGKGSYGVVKLAYNEDDDKYYAMKVVSKKKLMKQYGFPRRPPPRGPKAAQGEQPKVLGPLERVYQEIAILKKLDHLNIVKLVEVLDDPAEDNLHMVFELMQKGPVMEVPSDSPFSEDQARHYFRDIVLGIEYLHYQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDALLSSTAGTPAFMAPETLSDNRQSFSGKALDVWAMGVTLYCFVYGKCPFIDEYILALHNKIKSKVVEFPDTPTVSEGLKSLVSRMLDKNPDTRITIPEIKVDPWVTQDGKDPLPLEEEHCTVVEVTEEEVQNSVKFVPSLSAVILVKAMLRKRSFGNPFECPSRREERSMSAPGSLLMDSWPFRPSFKLQPSLRKGSSGEAPREAELEDLHEDEPPSS", "length": 497 }, "evidence": [ { "id": "A0AAA9S954", "url": "https://omabrowser.org/oma/group/A0AAA9S954/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P97756-1", "protein_name": "Calcium/calmodulin-dependent protein kinase kinase 1", "gene_name": "Camkk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERSPAVCCQDPRAELVERVAAISVAHLEEAEEGPEPASNGVDPPPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLEAQVGPYSTGPASHMSPRAWRRPTIESHHVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNEREDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAPQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDTGQSFSGKALDVWATGVTLYCFVYGKCPFIDEYILALHRKIKNEAVVFPEEPEVSEELKDLILKMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVKLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLLKEGCGEGGKSPELPGVQEDEAAS", "length": 505 }, "evidence": [ { "id": "A0AAA9S954", "url": "https://omabrowser.org/oma/group/A0AAA9S954/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N5S9-1", "protein_name": "Calcium/calmodulin-dependent protein kinase kinase 1", "gene_name": "CAMKK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLVKEGFGEGGKSPELPGVQEDEAAS", "length": 505 }, "evidence": [ { "id": "A0AAA9S954", "url": "https://omabrowser.org/oma/group/A0AAA9S954/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VBY2-1", "protein_name": "Calcium/calmodulin-dependent protein kinase kinase 1", "gene_name": "Camkk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESGPAVCCQDPRAELVDRVAAINVAHLEEADEGPEPARNGVDPPPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLGAQVGPYSTGPASHISPRSWRRPTIESHRVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGSLLMKEGCGEGCKSPELPGVQEDEAAS", "length": 505 }, "evidence": [ { "id": "A0AAA9S954", "url": "https://omabrowser.org/oma/group/A0AAA9S954/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "pmid": "" }, { "name": "calcium/calmodulin-dependent protein kinase activity", "id": "GO:0004683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004683", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S954", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-442749", "name": "CaMKK autophosphorylates in the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S954-1" ], "evidence": [ { "id": "R-BTA-442749", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442749" } ] }, { "id": "R-BTA-9619355", "name": "CaMKK autophosphorylates in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S954-1" ], "evidence": [ { "id": "R-BTA-9619355", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9619355" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 409, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.17", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17" }, { "id": "2.7.11.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.17" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S743-1", "uniprot_ac": "A0AAA9S743", "uniprot_id": "A0AAA9S743_BOVIN", "mass": { "chemical_mass": 74208.0, "monoisotopic_mass": 74208.0 }, "refseq": { "ac": "XP_024852832", "name": "coiled-coil domain-containing protein 170 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852832" }, "gene_names": [ { "name": "CCDC170", "type": "recommended", "evidence": [ { "id": "A0AAA9S743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743" } ] }, { "name": "CCDC170", "type": "synonym", "evidence": [ { "id": "XP_024852832", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852832" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 170", "type": "synonym", "evidence": [ { "id": "A0AAA9S743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 170 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024852832", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852832" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S743", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC170", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743", "locus": { "chromosome": "9", "start_pos": 88617041, "end_pos": 88521026, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004099", "url": "https://www.ensembl.org/id/ENSBTAG00000004099" } ] } } ], "crossref": [ { "id": "A0AAA9S743", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S743", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004099", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004099", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "787062", "url": "https://www.ncbi.nlm.nih.gov/gene/787062", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EQRTHNY", "url": "https://omabrowser.org/oma/group/EQRTHNY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR18863", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18863", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18863:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18863:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024852832", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852832", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S743", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S743-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC70", "url": "https://www.uniprot.org/uniprotkb/F1MC70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC70-1", "url": "https://www.uniprot.org/uniprotkb/F1MC70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSKEVSYQELKAEMESYKENNARKSSLLISLRDRVQELEEESAALATSKIRTEITAQSAIKENQELKKKVVELDEKLQKCLKENEENKNQVSQNCRKHEEFLAQLRDCLDPEKNEKASDEDLILKLGELCKENAFVKGQIVALEETINVHEMEAKASRETIMRLASEVNREQKKAASYIEEKGQLSQDLLGAMEAKEALEREVKVFQERLLAGQRVWDASKQELSLLKRSSLELEKSLKASLEATAASQTELSSFREKIAALLRGSSGTLRPSEDAILERIREMGSQEESGKQMVSQLEAQISKLVEQLGNESQFHQKALQRAQKAENQLEALQGRLTHLEEELVSGGVLQDDLHFEKQKYLKFLDQLSEKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMNFLRQKIAHLEQEKQVRSAVMVERDEANVTIRKLQKKVERLQKELSVCQELNTELKAKLADTSELKIKTLEQTRAIEDLNKSRDKLEKMKEKAEKKLLSVKSELETTEHEAKENKERARNMLEVVTSEMKTLKKSLEEAGKRERQLMDFREVVSQMLGLNMMSLALPDYEIIKCLERLIHAHQHRFVPCACLKDETAKQDRPPQGHVQLLH", "length": 645, "header": "tr|A0AAA9S743-1|A0AAA9S743_BOVIN Isoform 1 of Coiled-coil domain containing 170 OS=Bos taurus OX=9913 GN=CCDC170 PE=4 SV=1 CANONICAL=A0AAA9S743-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S743-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743/entry#A0AAA9S743-1", "sequence": { "sequence": "MLSKEVSYQELKAEMESYKENNARKSSLLISLRDRVQELEEESAALATSKIRTEITAQSAIKENQELKKKVVELDEKLQKCLKENEENKNQVSQNCRKHEEFLAQLRDCLDPEKNEKASDEDLILKLGELCKENAFVKGQIVALEETINVHEMEAKASRETIMRLASEVNREQKKAASYIEEKGQLSQDLLGAMEAKEALEREVKVFQERLLAGQRVWDASKQELSLLKRSSLELEKSLKASLEATAASQTELSSFREKIAALLRGSSGTLRPSEDAILERIREMGSQEESGKQMVSQLEAQISKLVEQLGNESQFHQKALQRAQKAENQLEALQGRLTHLEEELVSGGVLQDDLHFEKQKYLKFLDQLSEKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMNFLRQKIAHLEQEKQVRSAVMVERDEANVTIRKLQKKVERLQKELSVCQELNTELKAKLADTSELKIKTLEQTRAIEDLNKSRDKLEKMKEKAEKKLLSVKSELETTEHEAKENKERARNMLEVVTSEMKTLKKSLEEAGKRERQLMDFREVVSQMLGLNMMSLALPDYEIIKCLERLIHAHQHRFVPCACLKDETAKQDRPPQGHVQLLH", "length": 645, "header": "tr|A0AAA9S743-1|A0AAA9S743_BOVIN Isoform 1 of Coiled-coil domain containing 170 OS=Bos taurus OX=9913 GN=CCDC170 PE=4 SV=1 CANONICAL=A0AAA9S743-1" }, "locus": { "chromosome": "9", "start_pos": 88616037, "end_pos": 88554754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092812.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092812.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079127.1" } ] } }, { "isoform_ac": "A0AAA9TFH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743/entry#A0AAA9TFH4-1", "sequence": { "sequence": "MSSSSPRRPPPTGPAAFGASSPAPEKAYDHLLEVPVTREQLNHYRNVAEAARSELAATLVKFESAQSELRELRSKMLSKEVSYQELKAEMESYKENNARKSSLLISLRDRVQELEEESAALATSKIRTEITAQSAIKENQELKKKVVELDEKLQKCLKENEENKNQVSQNCRKHEEFLAQLRDCLDPEKNEKASDEDLILKDLLGAMEAKEALEREVKVFQERLLAGQRVWDASKQELSLLKRSSLELEKSLKASLEATAASQTELSSFREKIAALLRGSSGTLRPSEDAILERIREMGSQEESGKQMVSQLEAQISKLVEQLGNESQFHQKALQRAQKAENQLEALQGRLTHLEEELVSGGVLQDDLHFEKQKYLKFLDQLSEKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMNFLRQKIAHLEQEKQVRSAVMVERDEANVTIRKLQKKVERLQKELSVCQELNTELKAKLADTSELKIKTLEQTRAIEDLNKSRDKLEKMKEKAEKKLLSVKSELETTEHEAKENKERARNMLEVVTSEMKTLKKSLEEAGKRERQLMDFREVVSQMLGLNMMSLALPDYEIIKCLERLIHAHQHRFVPCACLKDETAKQDRPPQGHVQLLH", "length": 658, "header": "tr|A0AAA9TFH4-1|A0AAA9TFH4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 170 OS=Bos taurus OX=9913 GN=CCDC170 PE=4 SV=1 CANONICAL=A0AAA9S743-1" }, "locus": { "chromosome": "9", "start_pos": 88616037, "end_pos": 88521285, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128762.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128762.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095609.1" } ] } }, { "isoform_ac": "F1MC70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743/entry#F1MC70-1", "sequence": { "sequence": "MSSSSPRRPPPTGPAAFGASSPAPEKAYDHLLEVPVTREQLNHYRNVAEAARSELAATLVKFESAQSELRELRSKMLSKEVSYQELKAEMESYKENNARKSSLLISLRDRVQELEEESAALATSKIRTEITAQSAIKENQELKKKVVELDEKLQKCLKENEENKNQVSQNCRKHEEFLAQLRDCLDPEKNEKASDEDLILKLGELCKENAFVKGQIVALEETINVHEMEAKASRETIMRLASEVNREQKKAASYIEEKGQLSQDLLGAMEAKEALEREVKVFQERLLAGQRVWDASKQELSLLKRSSLELEKSLKASLEATAASQTELSSFREKIAALLRGSSGTLRPSEDAILERIREMGSQEESGKQMVSQLEAQISKLVEQLGNESQFHQKALQRAQKAENQLEALQGRLTHLEEELVSGGVLQDDLHFEKQKYLKFLDQLSEKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMNFLRQKIAHLEQEKQVRSAVMVERDEANVTIRKLQKKVERLQKELSVCQELNTELKAKLADTSELKIKTLEQTRAIEDLNKSRDKLEKMKEKAEKKLLSVKSELETTEHEAKENKERARNMLEVVTSEMKTLKKSLEEAGKRERQLMDFREVVSQMLGLNMMSLALPDYEIIKCLERLIHAHQHRFVPCACLKDETAKQDRPPQGHVQLLH", "length": 720, "header": "tr|F1MC70-1|A0AAA9S743_BOVIN Computationally mapped isoform of Coiled-coil domain containing 170 OS=Bos taurus OX=9913 GN=CCDC170 PE=4 SV=4 CANONICAL=A0AAA9S743-1" }, "locus": { "chromosome": "9", "start_pos": 88616037, "end_pos": 88521285, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005361.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005361.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005361.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005361.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MPS2-1", "protein_name": "Coiled-coil domain-containing protein 170 isoform X1", "gene_name": "Ccdc170", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSHSSSSGSGSLERPSNASPPEETANHPMEFPGTWEQLNHYRNVAENVQSELAATLVKFECAQSELRDLRSKLLSKEVCCQELKAEVESYKENSARKSSLLISLRSRIQELQEESAALSASKIRTETSAHTTMKENQELMKKVLELDEKLQNCLKENEESKKQGLENLRRHEEFRTELCDCLSLDKKHEEASNEDLILKLRELCKENTLLKGQIVTLEETINVHEMEAKANRETISRLAAEVSREQTRAASWAMEKDKLNQDLLSAVDARTALEREAKLFQERLLVAQRAWDASKQELNQLRKNCQHLDLSLKASRDAAATSQSQNSSFREKLTVLLCNGLDMAVPTEDAILERIRELGIQEESKTRMVSQLEAQISELVEQLGNEAELHRKDLQRAQEAESKLEALQGQLSHLEGELLSGDVLRDNLNLEKQKYLQFLDQLSEKMKLGEIADDLGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKEVHMNLLRQKIAQLQQETQARTALAVERDEAHLTVRKLEKKVERMQKELSACREYNTELKAQLADTNELKIKTLEQTKVIEDLSKSRDNLEKLKEKAEKKLMLLKSKLDTAEEEAKADKGRMTAIMELVTSELETLKKSLEEAERREQQLVEFREVVSQTLGLNLTSLAVPDYEIIKCLERVVHSHHHHLVTCACLKDTSAEHDSCPKCCLELLH", "length": 718 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LHN4-1", "protein_name": "Coiled-coil domain containing 170", "gene_name": "Ccdc170", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHSSSLGSGSPECPRNASPPEGTADHHPEVPVTREQLNHYRNVAENVQSELAAALVRFECAQSELRELRSKMLSKEVCCQELKAEMESYKENSARKSSLLVSLRGRIQELQEESAAFSASKIRAEASAHAMMKENQELMKKVLELDEKLQDCSKANEESKKQGSETLRRHEEFRTQLRDCLSLDKKCEEAPDEDLVLKLKELCKENTSLKGQLTTLEETVSVHEMEAKANRETILRLAADVSREQTKAASWAEEKDKLNQDLLSAAEARTALEREAMLYQERLLASQRAWDASKQELNQLRKSCQQLDVSLKASREAATASQSQNACFREKLAALLCSRFDIAESTEDAILEKIRVLGIEEENQKRMASQLEAQISELVGKLGNESESHQKALQRAHEAEKKLEALQGQLSHLEGELLSGDVVRDNLNLEKQKYLKFLDQLSEKMKLGHIAADLGFDMRLDVVLARIEQLVHLESNAVIENKTMAHNLQRKLKTQKERLESKEVHMNLLRQKITQLQQEKEARSALAMERDEAHLSVRKLEKKVERMQKELSSCQEYNTELKAKLADTSELKIKTLEQTKAIEDLNQSRGELEKMKENAEKKLMLVMSELETTVQEAQANQERTRAMIELASSELRILKKSLDEAERREQQLADFREVVSSMLGLNVTSLALPDYEIIKCLERLIHSHHHHHHHHHFVPCACLKDMAAEQASPHSAT", "length": 718 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3YXL0-1", "protein_name": "Coiled-coil domain containing 170", "gene_name": "Ccdc170", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSHSSSLGSGSPECPCNSSPPEGTASHRPEVPDTWEQLNHYRNVTENVQSELAAMLVKFECAQSELRELRSKMLSKEACCQELKVEMESYKESSARKSALLTSLRGRMEELQEESAAVSASKSRAEASVHAMMKENQELMKKVLELDEKLQNCSKENEESKKQGSEHLRRHEEFRAQLHDCLSLDKKHEEASDEDLILKLRELYKEPTFLKGQLATLEETVTVHEMEAKANRETIRRLAAEVSREQTKAASWAEEKDKLNQDLLSAVEGRTALEREVKLYQERLLASQRAWDASKQELTQLRKRCQELDVSLKASREATTASQSRNSCFREKLTALLCSRFDTAESTEDAILERIRELGIEEESQRRMASQLEAQISEFVGKLGNESESHQKALQRAHVAEKKLEALQSQLSHLEGELLSGDVVRDNLFLEKQKYLKFLDQLTEKMKLGHVAADLGFDVCLDVVLARIEQLVRLESNAVIENKTMAHNLQRKLKTQKERLESKEVHMNLLRQKIAQLQQEKEARSALAVERDEAHLAMRKLEKKLERMQKELSACQEHNTELKAKLADTNELKIKTLEQTKAIEDLNQSRDELEKMKENAEKKLMLVMSELENTEQEARAHQERSRAMIELASLELKTLRKSLDEAERRGMQLADFREVVSSMLGLNMTSHDPPDYEIIKCLERLLHSHRHHHHHHFVPCACLQDMAAEQGSCSHCRVEIPH", "length": 722 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E7F1G2-1", "protein_name": "Coiled-coil domain-containing protein 170", "gene_name": "ccdc170", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMDESVIQQHLSHYKQATETAREELAALQAKHNSLQTQLSESQSRVVSQEETLRSLKDAVDRYKEKEARQESLIGSLRERNYNTEQEMISITSTRSIMDIRIQTLTKENQEIKEKIMQLEVESKQYVAECNKAKQEAAEAQRKCEEFISTLANKISVIATGKADPMDYIVSVVDACFKDRERLKNCVCALEESVKLYEVECKASRETVKRLATDVDREQTLSASRANELNSSRQELDLISLRKVSLERENQSAKVSLQEAEAALASAQQLCRHYENLSQDLQNKLQISQNEAKASHRHHGAFMKKVETLLDDHSLPGQHTEQDMLSALTDLCKRETSAQKSQMEMEVRLAEMVEQLSSIKEHQNTSEQKKQELLDRIQSLEDELINARVCKDGMNQDKQQYLRFVEQLSEMLKVDDVAAELGFDMRLEVILTRAQQLSRHEGTALLETKTQTYSLQRKLKEQKSRSESKDLYLELLRRKVQQLEEEKRSRSTLALEKDDAALSCKKLQKRVDRLQAELSTLRFSNTELKAQLSHTNQLQITVMEQKQTIEEQNKNLGKLEKKKVKTEQKLTSVTSELKSQELKARDEIQQAHRLLDTQSSAIADLTHTEKQLLDFYTVVSQMLGVHCTGCIPNYEVLRRLEVLIQSRQCHSTAHLHTCWNSPVSSINVDQSHEFKPQALPAASSPTASLINPH", "length": 693 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3L7N5-1", "protein_name": "Coiled-coil domain containing 170", "gene_name": "CCDC170", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSSGPRRLQPIGPAAFGASPPAPEETYDRLLEVPVTREQLNHYRNVAETARSELAATLVKFESAQAELRDLQSKMRSKEVSCQELKAEMENYKESNARKASLLISLRDRVQELEEESVVLSTSKIRTEIAAHSAVKENQELKKNFVELDEKLQKCLKDNEENKKQVLQSCRKHEKFLAALRDSLDPEKKNEKASDEDLILKVGELCKENALVKGQIVALEETVSVHEMEAEASRETIVRLASEVNREQKKAASCTEEKDKLNQDLLTAVEAKEALEKEVKILQERLLAGQRVWDASKQELSLLKKSSLELEKSCKASLDAAAASQSQYSSFREKIAAHLRGGSGPLKPTEDAILERIREMGSQEESGKQMVTQLEAQISELVEQLGNESGFHQKALQRAQKAENKLETLQGQLTHLEGELVSGDVLRDTLHVEKQKYLQFLDQLSEKMKLDRMAAELGFDMRLEVVLARTEQLVRLESNAVIEHKTIAHNLQRKLKTQKERLESKELHVNLLRQKIAQLEEERQMRSALTVERDEAKVTIRKLQKQVERLQKELSLCRQMNTELKAKLADTNELKIKTLEQTKTIEDLNKSRDTLEKMKEKAEKKLLSVKSELDTAEHEAKENKERAKNMLEVVTSETKTLKKSLEEAEKREKQLVDFREVVSQMLGLNMSSLALPDYEIIKCLERLIHSHQHPFVTCACLKDVPTRQDRHLQGHLQLLH", "length": 721 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M9NDT0-1", "protein_name": "Coiled-coil domain-containing protein 170", "gene_name": "CG15165", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPLNPRPTTNGNTPEDWQVFEVLFGADQDPKTIPARMTTMSPLPQPAIPFCQLDTSCSNTGITVTEHHHGLDLTTTLRSELAALSYKKERLTGELAEARAALCSKDADIENLRAQAARQTALIGSLQSRLQNSESREQAVQARCDSTIQTVQREKRSSDERNKELICKIQHLETHMASEESQKEQIKAQLHDLLRRLSITLGMDVCDGNQNSHATPECIISRAEEVMVELQRTKAKVSSTCDTLSSCENELLNLKSLANIEKQRLTAQLDGAGNHNHELEGRCRQYERDLQIQRDRLTESEINGEKLKEELRGFESRCHRLQNNLDRTQGDRLQFLRGLSNLLNVPEPCETLIKDKLREILAENQAMHAQMHSLRDQLNSEHEKLKETQQTTECRLRSGEAQKCELTERLEKCHAEIHTLRKDHMGLSEFLQRLALAMNWGECSAPPALGTDTNLMAENLLERAERLAAHCDHEAPHHHHHHHSPDKGCCDHGHGHGKLRRERSCHDIPLKESSSVYNLQRRVRVLREQVQRRDLHLELLRRKLAIIEDGARGKCMLQGERDEAVCRAKKAAKQVDKLSAQLADARSQIAEVKAQLAEAVEYKITSLERARKIDELTTQICDLEDEKTRLLSQLNALKERLKSSCESNQNRRCRDEALINSMRDDVSRLSSQLSDANQRLSHLQSFRTSVARTLHLRDLPETDLLHRLQALCSAHQEFTMLSKRYETASPVGDHPCPRFDDPIPPSSHCRPPRELSPPPTSFHHKATIHSGSSHHSPPSEHHHGSSSHVHNHHGHGHGHGHSSHSRRQRSKSRDKRLHDECFDTDVHRLHHGCKEELLATGSEDDYDFKSKYC", "length": 853 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8IYT3-1", "protein_name": "Coiled-coil domain-containing protein 170", "gene_name": "CCDC170", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQHHFVTCACLKDVTTGQERHPQGHLQLLH", "length": 715 }, "evidence": [ { "id": "A0AAA9S743", "url": "https://omabrowser.org/oma/group/A0AAA9S743/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S743", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S743", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S743", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S743", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S743" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 312, "end_pos": 314 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 462, "end_pos": 464 }, { "start_pos": 514, "end_pos": 516 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8W9-1", "uniprot_ac": "A0AAA9S8W9", "uniprot_id": "A0AAA9S8W9_BOVIN", "mass": { "chemical_mass": 78594.0, "monoisotopic_mass": 78594.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF23", "type": "recommended", "evidence": [ { "id": "A0AAA9S8W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ] } ], "protein_names": [ { "name": "Zinc finger protein 23", "type": "synonym", "evidence": [ { "id": "A0AAA9S8W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9", "locus": { "chromosome": "18", "start_pos": 39627522, "end_pos": 39612613, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050281", "url": "https://www.ensembl.org/id/ENSBTAG00000050281" } ] } } ], "crossref": [ { "id": "A0AAA9S8W9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8W9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050281", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050281", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781790", "url": "https://www.ncbi.nlm.nih.gov/gene/781790", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781790", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781790", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MS97", "url": "https://www.orthodb.org/?gene=F1MS97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P272", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P272", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P272-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P272-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P553", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P553", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P553-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P553-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS97", "url": "https://www.uniprot.org/uniprotkb/F1MS97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS97-1", "url": "https://www.uniprot.org/uniprotkb/F1MS97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAMLLTSWPESVTFEDVAVYFTQTEWDGLSTAQRALYRDVMLENYGNMASLGFPLLKPAVISQLEGGGELEGPSPLASAAGTGPQGLWTDIDIQTNNNLTEEMYEEKYNISYELQRNSFKETDFSETYILEKQQDVHSVGSVKKENSNVIDKMVKDSPSPMEECFFSQSPNLNQCHIISTGEQPPECTGLEKAFSFDTKLIQREIINSGERPFKCEELMENFSCNSQLNQGQDSYTGEKPHEYKDCGKAFSINAKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLSRHQRIHTGERPYQCKECGSSFSCSSAYIIHQRIHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECTECGRGFRCSSQLRQHQNIHTGERPFQCKECGKAFSSNAKLIQHQRIHTGEKPYECTECGKAFGVKGKLIQHQRIHTGEKPYECKECGKTFRCNSQLRQHLRIHTGEKPYECNECGKAFNVNAKLMQHQRIHTGEKPFECNECGKCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSYSSDCIIHQTVHTWKKPFVCNVCGKAFRFSFQLSQHQSIHSEEKS", "length": 689, "header": "tr|A0AAA9S8W9-1|A0AAA9S8W9_BOVIN Isoform 1 of Zinc finger protein 23 OS=Bos taurus OX=9913 GN=ZNF23 PE=3 SV=2 CANONICAL=A0AAA9S8W9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9/entry#A0AAA9S8W9-1", "sequence": { "sequence": "MAAMLLTSWPESVTFEDVAVYFTQTEWDGLSTAQRALYRDVMLENYGNMASLGFPLLKPAVISQLEGGGELEGPSPLASAAGTGPQGLWTDIDIQTNNNLTEEMYEEKYNISYELQRNSFKETDFSETYILEKQQDVHSVGSVKKENSNVIDKMVKDSPSPMEECFFSQSPNLNQCHIISTGEQPPECTGLEKAFSFDTKLIQREIINSGERPFKCEELMENFSCNSQLNQGQDSYTGEKPHEYKDCGKAFSINAKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLSRHQRIHTGERPYQCKECGSSFSCSSAYIIHQRIHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECTECGRGFRCSSQLRQHQNIHTGERPFQCKECGKAFSSNAKLIQHQRIHTGEKPYECTECGKAFGVKGKLIQHQRIHTGEKPYECKECGKTFRCNSQLRQHLRIHTGEKPYECNECGKAFNVNAKLMQHQRIHTGEKPFECNECGKCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSYSSDCIIHQTVHTWKKPFVCNVCGKAFRFSFQLSQHQSIHSEEKS", "length": 689, "header": "tr|A0AAA9S8W9-1|A0AAA9S8W9_BOVIN Isoform 1 of Zinc finger protein 23 OS=Bos taurus OX=9913 GN=ZNF23 PE=3 SV=2 CANONICAL=A0AAA9S8W9-1" }, "locus": { "chromosome": "18", "start_pos": 39626863, "end_pos": 39618329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089059.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089059.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082495.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082495.2" } ] } }, { "isoform_ac": "A0AAA9SZ83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9/entry#A0AAA9SZ83-1", "sequence": { "sequence": "MKSVTFEDVAVYFTQTEWDGLSTAQRALYRDVMLENYGNMASLGFPLLKPAVISQLEGGGELEGPSPLASAAGTGPQGLWTDIDIQTNNNLTEEMYEEKYNISYELQRNSFKETDFSETYILEKQQDVHSVGSVKKENSNVIDKMVKDSPSPMEECFFSQSPNLNQCHIISTGEQPPECTGLEKAFSFDTKLIQREIINSGERPFKCEELMENFSCNSQLNQGQDSYTGEKPHEYKDCGKAFSINAKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLSRHQRIHTGERPYQCKECGSSFSCSSAYIIHQRIHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECTECGRGFRCSSQLRQHQNIHTGERPFQCKECGKAFSSNAKLIQHQRIHTGEKPYECTECGKAFGVKGKLIQHQRIHTGEKPYECKECGKTFRCNSQLRQHLRIHTGEKPYECNECGKAFNVNAKLMQHQRIHTGEKPFECNECGKCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSYSSDCIIHQTVHTWKKPFVCNVCGKAFRFSFQLSQHQSIHSEEKS", "length": 680, "header": "tr|A0AAA9SZ83-1|A0AAA9SZ83_BOVIN Computationally mapped isoform of Zinc finger protein 23 OS=Bos taurus OX=9913 GN=ZNF23 PE=3 SV=1 CANONICAL=A0AAA9S8W9-1" }, "locus": { "chromosome": "18", "start_pos": 39626863, "end_pos": 39620058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092831.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092831.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091759.1" } ] } }, { "isoform_ac": "A0ABI0P272-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9/entry#A0ABI0P272-1", "sequence": { "sequence": "MLVLKDIDIQTNNNLTEEMYEEKYNISYELQRNSFKETDFSETYILEKQQDVHSVGSVKKENSNVIDKMVKDSPSPMEECFFSQSPNLNQCHIISTGEQPPECTGLEKAFSFDTKLIQREIINSGERPFKCEELMENFSCNSQLNQGQDSYTGEKPHEYKDCGKAFSINAKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLSRHQRIHTGERPYQCKECGSSFSCSSAYIIHQRIHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECTECGRGFRCSSQLRQHQNIHTGERPFQCKECGKAFSSNAKLIQHQRIHTGEKPYECTECGKAFGVKGKLIQHQRIHTGEKPYECKECGKTFRCNSQLRQHLRIHTGEKPYECNECGKAFNVNAKLMQHQRIHTGEKPFECNECGKCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSYSSDCIIHQTVHTWKKPFVCNVCGKAFRFSFQLSQHQSIHSEEKS", "length": 604, "header": "tr|A0ABI0P272-1|A0ABI0P272_BOVIN Computationally mapped isoform of Zinc finger protein 23 OS=Bos taurus OX=9913 GN=ZNF23 PE=3 SV=1 CANONICAL=A0AAA9S8W9-1" }, "locus": { "chromosome": "18", "start_pos": 39626863, "end_pos": 39613427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140978.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140978.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107212.1" } ] } }, { "isoform_ac": "A0ABI0P553-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9/entry#A0ABI0P553-1", "sequence": { "sequence": "MAAMLLTSWPEKSVTFEDVAVYFTQTEWDGLSTAQRALYRDVMLENYGNMASLGFPLLKPAVISQLEGGDIDIQTNNNLTEEMYEEKYNISYELQRNSFKETDFSETYILEKQQDVHSVGSVKKENSNVIDKMVKDSPSPMEECFFSQSPNLNQCHIISTGEQPPECTGLEKAFSFDTKLIQREIINSGERPFKCEELMENFSCNSQLNQGQDSYTGEKPHEYKDCGKAFSINAKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLSRHQRIHTGERPYQCKECGSSFSCSSAYIIHQRIHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECTECGRGFRCSSQLRQHQNIHTGERPFQCKECGKAFSSNAKLIQHQRIHTGEKPYECTECGKAFGVKGKLIQHQRIHTGEKPYECKECGKTFRCNSQLRQHLRIHTGEKPYECNECGKAFNVNAKLMQHQRIHTGEKPFECNECGKCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSYSSDCIIHQTVHTWKKPFVCNVCGKAFRFSFQLSQHQSIHSEEKS", "length": 668, "header": "tr|A0ABI0P553-1|A0ABI0P553_BOVIN Computationally mapped isoform of Zinc finger protein 23 OS=Bos taurus OX=9913 GN=ZNF23 PE=3 SV=1 CANONICAL=A0AAA9S8W9-1" }, "locus": { "chromosome": "18", "start_pos": 39626863, "end_pos": 39618329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149407.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149407.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106802.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106802.1" } ] } }, { "isoform_ac": "F1MS97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9/entry#F1MS97-1", "sequence": { "sequence": "MYEEKYNISYELQRNSFKETDFSETYILEKQQDVHSVGSVKKENSNVIDKMVKDSPSPMEECFFSQSPNLNQCHIISTGEQPPECTGLEKAFSFDTKLIQREIINSGERPFKCEELMENFSCNSQLNQGQDSYTGEKPHEYKDCGKAFSINAKLIWHQRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLSRHQRIHTGERPYQCKECGSSFSCSSAYIIHQRIHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECTECGRGFRCSSQLRQHQNIHTGERPFQCKECGKAFSSNAKLIQHQRIHTGEKPYECTECGKAFGVKGKLIQHQRIHTGEKPYECKECGKTFRCNSQLRQHLRIHTGEKPYECNECGKAFNVNAKLMQHQRIHTGEKPFECNECGKCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSYSSDCIIHQTVHTWKKPFVCNVCGKAFRFSFQLSQHQSIHSEEKS", "length": 586, "header": "tr|F1MS97-1|A0AAA9S8W9_BOVIN Computationally mapped isoform of Zinc finger protein 23 OS=Bos taurus OX=9913 GN=ZNF23 PE=3 SV=5 CANONICAL=A0AAA9S8W9-1" }, "locus": { "chromosome": "18", "start_pos": 39626863, "end_pos": 39625106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017799.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017799.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017799.8", "url": "https://www.ensembl.org/id/ENSBTAP00000017799.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781790", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781790", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 241, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W9" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 84, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 222, "end_pos": 224 }, { "start_pos": 310, "end_pos": 312 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6E2-1", "uniprot_ac": "A0AAA9S6E2", "uniprot_id": "A0AAA9S6E2_BOVIN", "mass": { "chemical_mass": 22369.0, "monoisotopic_mass": 22369.0 }, "refseq": { "ac": "XP_005204736", "name": "uncharacterized protein C1orf50 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204736" }, "gene_names": [ { "name": "C3H1orf50", "type": "recommended", "evidence": [ { "id": "A0AAA9S6E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2" } ] }, { "name": "C3H1orf50", "type": "synonym", "evidence": [ { "id": "XP_005204736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204736" } ] } ], "protein_names": [ { "name": "Chromosome 3 C1orf50 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9S6E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C1orf50 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204736" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C3H1orf50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2", "locus": { "chromosome": "3", "start_pos": 103464493, "end_pos": 103472223, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017386", "url": "https://www.ensembl.org/id/ENSBTAG00000017386" } ] } } ], "crossref": [ { "id": "A0AAA9S6E2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6E2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017386", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017386", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507125", "url": "https://www.ncbi.nlm.nih.gov/gene/507125", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MZT6", "url": "https://www.orthodb.org/?gene=F1MZT6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14553", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14553", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14553:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14553:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10504", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10504", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204736", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204736", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZT6", "url": "https://www.uniprot.org/uniprotkb/F1MZT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZT6-1", "url": "https://www.uniprot.org/uniprotkb/F1MZT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDTATPGGTQGVTENQGVLSAAGRGGALVELTPNPGGLALVSPYHTHRAGDPLDLVALAEQVQKANEFIRANATNKLTVIAEQIEHLQEQARKVLEDARRDADLHHVACNMVKKPGSIYYLYKRESGQQYFSIISPEEWGTSRPHDFLGAYKLQHDLSWTPYEDIEKQDAKISVMSKLLSQPVALPPSTESNFPGFRSTESGL", "length": 204, "header": "tr|A0AAA9S6E2-1|A0AAA9S6E2_BOVIN Isoform 1 of Chromosome 3 C1orf50 homolog OS=Bos taurus OX=9913 GN=C3H1orf50 PE=4 SV=1 CANONICAL=A0AAA9S6E2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2/entry#A0AAA9S6E2-1", "sequence": { "sequence": "MEDTATPGGTQGVTENQGVLSAAGRGGALVELTPNPGGLALVSPYHTHRAGDPLDLVALAEQVQKANEFIRANATNKLTVIAEQIEHLQEQARKVLEDARRDADLHHVACNMVKKPGSIYYLYKRESGQQYFSIISPEEWGTSRPHDFLGAYKLQHDLSWTPYEDIEKQDAKISVMSKLLSQPVALPPSTESNFPGFRSTESGL", "length": 204, "header": "tr|A0AAA9S6E2-1|A0AAA9S6E2_BOVIN Isoform 1 of Chromosome 3 C1orf50 homolog OS=Bos taurus OX=9913 GN=C3H1orf50 PE=4 SV=1 CANONICAL=A0AAA9S6E2-1" }, "locus": { "chromosome": "3", "start_pos": 103471977, "end_pos": 103464812, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113551.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113551.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080769.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080769.1" } ] } }, { "isoform_ac": "F1MZT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2/entry#F1MZT6-1", "sequence": { "sequence": "ASAGAPPPDSWQFRRLVVRRRGSSAHGLFCACSAVSRRLGSEKNKVLSWKIQQRPGGPRESQKTKEFCRRQVGEANEFIRANATNKLTVIAEQIEHLQEQARKVLEDARRDADLHHVACNMVKKPGSIYYLYKRESGQQYFSIISPEEWGTSRPHDFLGAYKLQHDLSWTPYEDIEKQDAKISVMSKLLSQPVALPPSTESNFPGFRSTESGL", "length": 213, "header": "tr|F1MZT6-1|A0AAA9S6E2_BOVIN Computationally mapped isoform of Chromosome 3 C1orf50 homolog OS=Bos taurus OX=9913 GN=C3H1orf50 PE=4 SV=3 CANONICAL=A0AAA9S6E2-1" }, "locus": { "chromosome": "3", "start_pos": 103472120, "end_pos": 103464812, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023118.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023118.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023118.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023118.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 6, "start_aa": "Thr", "end_pos": 6, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr6", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 6 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7E5-1", "uniprot_ac": "A0AAA9S7E5", "uniprot_id": "A0AAA9S7E5_BOVIN", "mass": { "chemical_mass": 55138.0, "monoisotopic_mass": 55138.0 }, "refseq": {}, "gene_names": [ { "name": "GABRA3", "type": "recommended", "evidence": [ { "id": "A0AAA9S7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ] } ], "protein_names": [ { "name": "Gamma-aminobutyric acid type A receptor subunit alpha3", "type": "synonym", "evidence": [ { "id": "A0AAA9S7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GABRA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5", "locus": { "chromosome": "X", "start_pos": 34601278, "end_pos": 34842545, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006691", "url": "https://www.ensembl.org/id/ENSBTAG00000006691" } ] } } ], "crossref": [ { "id": "A0AAA9S7E5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7E5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006691", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006691", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19036", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19036", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19052", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19052", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MCS2", "url": "https://www.orthodb.org/?gene=F1MCS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02931", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02931", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02932", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02932", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-977443", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977443", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCS2", "url": "https://www.uniprot.org/uniprotkb/F1MCS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCS2-1", "url": "https://www.uniprot.org/uniprotkb/F1MCS2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIITQMSQFYMAGLGLLFLINILPGTTGQVESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKTPAVPTKKTSTTFNIVGTTYPINLAKDTEFSAISKGAAPSTSSTPTIIASPKTTCVQDIPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ", "length": 491, "header": "tr|A0AAA9S7E5-1|A0AAA9S7E5_BOVIN Isoform 1 of Gamma-aminobutyric acid type A receptor subunit alpha3 OS=Bos taurus OX=9913 GN=GABRA3 PE=3 SV=1 CANONICAL=A0AAA9S7E5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5/entry#A0AAA9S7E5-1", "sequence": { "sequence": "MIITQMSQFYMAGLGLLFLINILPGTTGQVESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKTPAVPTKKTSTTFNIVGTTYPINLAKDTEFSAISKGAAPSTSSTPTIIASPKTTCVQDIPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ", "length": 491, "header": "tr|A0AAA9S7E5-1|A0AAA9S7E5_BOVIN Isoform 1 of Gamma-aminobutyric acid type A receptor subunit alpha3 OS=Bos taurus OX=9913 GN=GABRA3 PE=3 SV=1 CANONICAL=A0AAA9S7E5-1" }, "locus": { "chromosome": "X", "start_pos": 34744052, "end_pos": 34602282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079836.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079836.1" } ] } }, { "isoform_ac": "A0AAA9SI11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5/entry#A0AAA9SI11-1", "sequence": { "sequence": "MPGLSKLVPKKMIITQMSQFYMAGLGLLFLINILPGTTGQVESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAVPTKKTSTTFNIVGTTYPINLAKDTEFSAISKGAAPSTSSTPTIIASPKTTCVQDIPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ", "length": 503, "header": "tr|A0AAA9SI11-1|A0AAA9SI11_BOVIN Computationally mapped isoform of Gamma-aminobutyric acid type A receptor subunit alpha3 OS=Bos taurus OX=9913 GN=GABRA3 PE=3 SV=1 CANONICAL=A0AAA9S7E5-1" }, "locus": { "chromosome": "X", "start_pos": 34755042, "end_pos": 34602282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101204.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101204.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084976.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084976.1" } ] } }, { "isoform_ac": "A0AAA9SWA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5/entry#A0AAA9SWA3-1", "sequence": { "sequence": "MIITQMSQFYMAGLGLLFLINILPGTTGQVESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKVVPCLKYAVPVWLLQWRKDRCIKAMMIANFRYLKGSHKYLMKYVVDLFFVIGKRCSGGLRVERALEQCSCQK", "length": 453, "header": "tr|A0AAA9SWA3-1|A0AAA9S7E5_BOVIN Computationally mapped isoform of Gamma-aminobutyric acid type A receptor subunit alpha3 OS=Bos taurus OX=9913 GN=GABRA3 PE=3 SV=1 CANONICAL=A0AAA9S7E5-1" }, "locus": { "chromosome": "X", "start_pos": 34744052, "end_pos": 34612131, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111253.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111253.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087511.1" } ] } }, { "isoform_ac": "F1MCS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5/entry#F1MCS2-1", "sequence": { "sequence": "MRTPWRPTERHSTWSSTPRPPSIKPSVLFHPDSFLQGSPASRLWTGTYSWQGRNPRCTAGGLSKLVPKKMIITQMSQFYMAGLGLLFLINILPGTTGQVESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAVPTKKTSTTFNIVGTTYPINLAKDTEFSAISKGAAPSTSSTPTIIASPKTTCVQDIPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ", "length": 561, "header": "tr|F1MCS2-1|F1MCS2_BOVIN Computationally mapped isoform of Gamma-aminobutyric acid type A receptor subunit alpha3 OS=Bos taurus OX=9913 GN=GABRA3 PE=3 SV=2 CANONICAL=A0AAA9S7E5-1" }, "locus": { "chromosome": "X", "start_pos": 34809305, "end_pos": 34602282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008798.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008798.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008798.4", "url": "https://www.ensembl.org/id/ENSBTAP00000008798.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-977443", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977443", "resource": "Reactome", "description": "GABA receptor activation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "chloride channel complex", "id": "GO:0034707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "dendrite membrane", "id": "GO:0032590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "GABA-A receptor complex", "id": "GO:1902711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902711", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "postsynaptic specialization membrane", "id": "GO:0099634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "gamma-aminobutyric acid signaling pathway", "id": "GO:0007214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "synaptic transmission, GABAergic", "id": "GO:0051932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "inhibitory synapse assembly", "id": "GO:1904862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904862", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "chloride channel activity", "id": "GO:0005254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005254", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "GABA-A receptor activity", "id": "GO:0004890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004890", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "extracellular ligand-gated monoatomic ion channel activity", "id": "GO:0005230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005230", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "GABA-gated chloride ion channel activity", "id": "GO:0022851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022851", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" }, { "name": "transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "id": "GO:1904315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" }, { "id": "PF02931", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02931" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Neurotransmitter-gated ion-channel ligand-binding", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 275, "start_aa": "Thr", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7E5" }, { "id": "PF02932", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02932" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Neurotransmitter-gated ion-channel transmembrane", "eco_id": "ECO_0000259", "start_pos": 282, "end_pos": 474, "start_aa": "Thr", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9H4-1", "uniprot_ac": "A0AAA9S9H4", "uniprot_id": "A0AAA9S9H4_BOVIN", "mass": { "chemical_mass": 79412.0, "monoisotopic_mass": 79412.0 }, "refseq": {}, "gene_names": [ { "name": "ME3", "type": "recommended", "evidence": [ { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ] } ], "protein_names": [ { "name": "Malic enzyme", "type": "recommended", "evidence": [ { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4", "locus": { "chromosome": "29", "start_pos": 9112316, "end_pos": 8891472, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000246", "url": "https://www.ensembl.org/id/ENSBTAG00000000246" } ] } } ], "crossref": [ { "id": "A0AAA9S9H4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9H4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05312", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05312", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23406:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23406:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03949", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03949", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RWQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S310", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S310-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAALGTGARLTLRSGRACGAVRSWAPPAPARGCHSKARPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEPPGRKRLASPPCPSAPSTEPGDLPDPGIKSTSLRPLHWQAGCLPAALRVTSLFILALVVFLQNSESLVLFKASASLKGHKGCVLVVSLSFKHPRATRWRDNGGNCSDWPPVRGKQIAQEVSEHHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPEDKEAFVRSLVYTPEYDSFTLDSYTWPEEAMNVQTI", "length": 718, "header": "tr|A0AAA9S9H4-1|A0AAA9S9H4_BOVIN Isoform 1 of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#A0AAA9RWQ3-1", "sequence": { "sequence": "MGAALGTGARLTLRSGRACGAVRSWAPPAPARGCHSKARPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEVLDFAYKHNLASYYPEPEDKEAFVRSLVYTPEYDSFTLDSYTWPEEAMNVQTI", "length": 571, "header": "tr|A0AAA9RWQ3-1|A0AAA9S9H4_BOVIN Computationally mapped isoform of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "locus": { "chromosome": "29", "start_pos": 9112241, "end_pos": 8891884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127363.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127363.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076896.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076896.1" } ] } }, { "isoform_ac": "A0AAA9S310-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#A0AAA9S310-1", "sequence": { "sequence": "MGAALGTGARLTLRSGRACGAVRSWAPPAPARGCHSKARPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAETRKQAPRGVTWLMSNAPGGPQAMCLEATAEHWQCPAS", "length": 555, "header": "tr|A0AAA9S310-1|A0AAA9S9H4_BOVIN Computationally mapped isoform of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "locus": { "chromosome": "29", "start_pos": 9108233, "end_pos": 8891884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077658.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077658.1" } ] } }, { "isoform_ac": "A0AAA9S9H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#A0AAA9S9H4-1", "sequence": { "sequence": "MGAALGTGARLTLRSGRACGAVRSWAPPAPARGCHSKARPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEPPGRKRLASPPCPSAPSTEPGDLPDPGIKSTSLRPLHWQAGCLPAALRVTSLFILALVVFLQNSESLVLFKASASLKGHKGCVLVVSLSFKHPRATRWRDNGGNCSDWPPVRGKQIAQEVSEHHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPEDKEAFVRSLVYTPEYDSFTLDSYTWPEEAMNVQTI", "length": 718, "header": "tr|A0AAA9S9H4-1|A0AAA9S9H4_BOVIN Isoform 1 of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "locus": { "chromosome": "29", "start_pos": 9112241, "end_pos": 8891884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093601.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093601.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080060.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080060.1" } ] } }, { "isoform_ac": "A0AAA9TBY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#A0AAA9TBY6-1", "sequence": { "sequence": "MGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEHHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPEDKEAFVRSLVYTPEYDSFTLDSYTWPEEAMNVQTI", "length": 544, "header": "tr|A0AAA9TBY6-1|A0AAA9TBY6_BOVIN Computationally mapped isoform of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "locus": { "chromosome": "29", "start_pos": 9112241, "end_pos": 8938460, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094202.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094202.1" } ] } }, { "isoform_ac": "A0AAA9TYB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#A0AAA9TYB8-1", "sequence": { "sequence": "MGAALGTGARLTLRSGRACGAVRSWAPPAPARGCHSKARPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEHHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPEDKEAFVRSLVYTPEYDSFTLDSYTWPEEAMNVQTI", "length": 566, "header": "tr|A0AAA9TYB8-1|A0AAA9TYB8_BOVIN Computationally mapped isoform of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "locus": { "chromosome": "29", "start_pos": 9112241, "end_pos": 8891884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104788.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104788.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102212.1" } ] } }, { "isoform_ac": "A0AAF6DM68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4/entry#A0AAF6DM68-1", "sequence": { "sequence": "MGAALGTGARLTLRSGRACGAVRSWAPPAPARGCHSKARPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRVMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFLPIVYTPTVGLACQHYGLTFRRPRGLFITVHDKGHLATMLNSWPEDDIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPRQCLPVLLDVGTNNEELLRDPLYIGLKHRRVRGQEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGIPTTPLLPVGVAAIAGAFTEQILRDMASFHEHPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFPSVTLEDGRTFFPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEHHLSQGRLYPPLSTIRDVSLRIAIKVLDFAYKHNLASYYPEPEDKEAFVRSLVYTPEYDSFTLDSYTWPEEAMNVQTI", "length": 614, "header": "tr|A0AAF6DM68-1|A0AAA9S9H4_BOVIN Computationally mapped isoform of Malic enzyme OS=Bos taurus OX=9913 GN=ME3 PE=3 SV=1 CANONICAL=A0AAA9S9H4-1" }, "locus": { "chromosome": "29", "start_pos": 9112241, "end_pos": 8891884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000306.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000306.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000306.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000306.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" }, { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" }, { "name": "malate dehydrogenase (decarboxylating) (NADP+) activity", "id": "GO:0004473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004473", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" }, { "name": "malic enzyme activity", "id": "GO:0004470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004470", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" }, { "name": "NADP+ binding", "id": "GO:0070401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070401", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "pyruvate biosynthetic process", "id": "GO:0042866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042866", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" }, { "name": "malate metabolic process", "id": "GO:0006108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" }, { "id": "SM01274", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01274" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Malic enzyme N-terminal", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 295, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" }, { "id": "SM00919", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00919" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Malic enzyme NAD-binding", "eco_id": "ECO_0000259", "start_pos": 305, "end_pos": 527, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "A0AAA9TBY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6#function" }, { "id": "A0AAA9TBY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6" }, { "id": "PIRSR000106-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000106-3" } ], "binding_site_uniprot": 220, "amino_acid": "Pro", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 220, "end_pos": 220, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6#function" }, { "id": "A0AAA9TBY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6" }, { "id": "PIRSR000106-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000106-3" } ], "binding_site_uniprot": 221, "amino_acid": "Arg", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 221, "end_pos": 221, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6#function" }, { "id": "A0AAA9TBY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY6" }, { "id": "PIRSR000106-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000106-3" } ], "binding_site_uniprot": 244, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 244, "end_pos": 244, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9RWQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3#function" }, { "id": "A0AAA9RWQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3" }, { "id": "PIRSR000106-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000106-3" }, { "id": "A0AAA9S310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310#function" }, { "id": "A0AAA9S310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310" }, { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4#function" }, { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" }, { "id": "A0AAA9TYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8#function" }, { "id": "A0AAA9TYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8" }, { "id": "A0AAF6DM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68#function" }, { "id": "A0AAF6DM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68" } ], "binding_site_uniprot": 280, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 280, "end_pos": 280, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9RWQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3#function" }, { "id": "A0AAA9RWQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3" }, { "id": "PIRSR000106-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000106-3" }, { "id": "A0AAA9S310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310#function" }, { "id": "A0AAA9S310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310" }, { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4#function" }, { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" }, { "id": "A0AAA9TYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8#function" }, { "id": "A0AAA9TYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8" }, { "id": "A0AAF6DM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68#function" }, { "id": "A0AAF6DM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68" } ], "binding_site_uniprot": 281, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 281, "end_pos": 281, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9RWQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3#function" }, { "id": "A0AAA9RWQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ3" }, { "id": "PIRSR000106-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR000106-3" }, { "id": "A0AAA9S310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310#function" }, { "id": "A0AAA9S310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S310" }, { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4#function" }, { "id": "A0AAA9S9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9H4" }, { "id": "A0AAA9TYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8#function" }, { "id": "A0AAA9TYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYB8" }, { "id": "A0AAF6DM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68#function" }, { "id": "A0AAF6DM68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM68" } ], "binding_site_uniprot": 304, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 304, "end_pos": 304, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 622, "end_pos": 624 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S771-1", "uniprot_ac": "A0AAA9S771", "uniprot_id": "A0AAA9S771_BOVIN", "mass": { "chemical_mass": 37045.0, "monoisotopic_mass": 37045.0 }, "refseq": {}, "gene_names": [ { "name": "BRMS1L", "type": "recommended", "evidence": [ { "id": "A0AAA9S771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771" } ] } ], "protein_names": [ { "name": "BRMS1 like transcriptional repressor", "type": "synonym", "evidence": [ { "id": "A0AAA9S771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S771", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRMS1L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771", "locus": { "chromosome": "21", "start_pos": 46060752, "end_pos": 46014364, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018400", "url": "https://www.ensembl.org/id/ENSBTAG00000018400" } ] } } ], "crossref": [ { "id": "A0AAA9S771", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S771", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018400", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018400", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSS7", "url": "https://www.orthodb.org/?gene=A0A3Q1LSS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21964", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21964", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LSS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S771", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S771-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5K6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5K6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGRKLNMEQFFPSYLCVIYFFFQSEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFTKLTLTFQRPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS", "length": 315, "header": "tr|A0AAA9S771-1|A0AAA9S771_BOVIN Isoform 1 of BRMS1 like transcriptional repressor OS=Bos taurus OX=9913 GN=BRMS1L PE=3 SV=1 CANONICAL=A0AAA9S771-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771/entry#A0A3Q1LSS7-1", "sequence": { "sequence": "MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSWPDSSSPWDFPGKNTG", "length": 301, "header": "tr|A0A3Q1LSS7-1|A0AAA9S771_BOVIN Computationally mapped isoform of BRMS1 like transcriptional repressor OS=Bos taurus OX=9913 GN=BRMS1L PE=3 SV=2 CANONICAL=A0AAA9S771-1" }, "locus": { "chromosome": "21", "start_pos": 46053748, "end_pos": 46014386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077227.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077227.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060327.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060327.2" } ] } }, { "isoform_ac": "A0AAA9S771-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771/entry#A0AAA9S771-1", "sequence": { "sequence": "MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGRKLNMEQFFPSYLCVIYFFFQSEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFTKLTLTFQRPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS", "length": 315, "header": "tr|A0AAA9S771-1|A0AAA9S771_BOVIN Isoform 1 of BRMS1 like transcriptional repressor OS=Bos taurus OX=9913 GN=BRMS1L PE=3 SV=1 CANONICAL=A0AAA9S771-1" }, "locus": { "chromosome": "21", "start_pos": 46056904, "end_pos": 46014386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102824.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102824.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078012.1" } ] } }, { "isoform_ac": "A0AAF6Z5K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771/entry#A0AAF6Z5K6-1", "sequence": { "sequence": "MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTERKSFCLSSNLLFGDFLSHLHTKPLPPHWFRFISEHYMQNCEKFFWSLCLM", "length": 292, "header": "tr|A0AAF6Z5K6-1|A0AAF6Z5K6_BOVIN Computationally mapped isoform of BRMS1 like transcriptional repressor OS=Bos taurus OX=9913 GN=BRMS1L PE=3 SV=2 CANONICAL=A0AAA9S771-1" }, "locus": { "chromosome": "21", "start_pos": 46050720, "end_pos": 46014386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024481.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024481.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024481.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024481.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S771", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S771", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S771", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S771" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5V5-1", "uniprot_ac": "A0AAA9S5V5", "uniprot_id": "A0AAA9S5V5_BOVIN", "mass": { "chemical_mass": 81614.0, "monoisotopic_mass": 81614.0 }, "refseq": {}, "gene_names": [ { "name": "RCBTB2", "type": "recommended", "evidence": [ { "id": "A0AAA9S5V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5" } ] } ], "protein_names": [ { "name": "RCC1 and BTB domain containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S5V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RCBTB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5", "locus": { "chromosome": "12", "start_pos": 18241680, "end_pos": 18284264, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006647", "url": "https://www.ensembl.org/id/ENSBTAG00000006647" } ] } } ], "crossref": [ { "id": "A0AAA9S5V5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5V5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006647", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006647", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18354", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18354", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18529", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18529", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513632", "url": "https://www.ncbi.nlm.nih.gov/gene/513632", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MCW5", "url": "https://www.orthodb.org/?gene=F1MCW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22872", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22872", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22872:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22872:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00415", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00415", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LT46", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT46-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S503", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S503", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S503-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S503-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T079", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T079", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T079-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T079-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCW5", "url": "https://www.uniprot.org/uniprotkb/F1MCW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCW5-1", "url": "https://www.uniprot.org/uniprotkb/F1MCW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQEVRRGCRARIRPLADPHSGKPPLPAPRCPTSGRGSCESSPWGESPARGRLLRRVCACASPPARPGRGARGRHSCPVLGLRCRRACAQPRAVARRAALGSYPDPGLRPRRREMVSLALSVLKYCRLNLKCLLQIIYSSVKLRIDKSALHRDLELSSPRGSLTKGLHRTMEDYVEDELFLLYALYGKSGKMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 745, "header": "tr|A0AAA9S5V5-1|A0AAA9S5V5_BOVIN Isoform 1 of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=2 CANONICAL=A0AAA9S5V5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0A3Q1LT46-1", "sequence": { "sequence": "MAQEVRRGCRARIRPLADPHSGKPPLPAPRCPTSGRGSCESSPWGESPARGRLLRRVCACASPPARPGRGARGRHSCPVLGLRCRRACAQPRAVARRAALGSYPDPGLRPRRREMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 668, "header": "tr|A0A3Q1LT46-1|A0AAA9S5V5_BOVIN Computationally mapped isoform of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18284065, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069395.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069395.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058279.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058279.2" } ] } }, { "isoform_ac": "A0AAA9RWP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9RWP3-1", "sequence": { "sequence": "MAQEVRRGCRARIRPLADPHSGKPPLPAPRCPTSGRGSCESSPWGESPARGRLLRRVCACASPPARPGRGARGRHSCPVLGLRCRRACAQPRAVARRAALGSYPDPGLRPRRREGLHRTMEDYVEDELFLLYALYGKSGKMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 694, "header": "tr|A0AAA9RWP3-1|A0AAA9S5V5_BOVIN Computationally mapped isoform of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18284065, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114924.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114924.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075529.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075529.1" } ] } }, { "isoform_ac": "A0AAA9S503-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9S503-1", "sequence": { "sequence": "MVSLALSVLKYCRLNLKCLLGLHRTMEDYVEDELFLLYALYGKSGKMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 600, "header": "tr|A0AAA9S503-1|A0AAA9S5V5_BOVIN Computationally mapped isoform of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18275461, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099726.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099726.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080267.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080267.1" } ] } }, { "isoform_ac": "A0AAA9S5V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9S5V5-1", "sequence": { "sequence": "MAQEVRRGCRARIRPLADPHSGKPPLPAPRCPTSGRGSCESSPWGESPARGRLLRRVCACASPPARPGRGARGRHSCPVLGLRCRRACAQPRAVARRAALGSYPDPGLRPRRREMVSLALSVLKYCRLNLKCLLQIIYSSVKLRIDKSALHRDLELSSPRGSLTKGLHRTMEDYVEDELFLLYALYGKSGKMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 745, "header": "tr|A0AAA9S5V5-1|A0AAA9S5V5_BOVIN Isoform 1 of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=2 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18284065, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116936.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116936.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077544.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077544.2" } ] } }, { "isoform_ac": "A0AAA9SNQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9SNQ1-1", "sequence": { "sequence": "MAQEVRRGCRARIRPLADPHSGKPPLPAPRCPTSGRGSCESSPWGESPARGRLLRRVCACASPPARPGRGARGRHSCPVLGLRCRRACAQPRAVARRAALGSYPDPGLRPRRREQIIYSSVKLRIDKSALHRDLELSSPRGSLTKGLHRTMEDYVEDELFLLYALYGKSGKMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 725, "header": "tr|A0AAA9SNQ1-1|A0AAA9SNQ1_BOVIN Computationally mapped isoform of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18284065, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121255.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121255.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084495.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084495.1" } ] } }, { "isoform_ac": "A0AAA9SU17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9SU17-1", "sequence": { "sequence": "MPVKDERGDLDVSKVVKPVFQSYFKDITATESAFQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 569, "header": "tr|A0AAA9SU17-1|A0AAA9SU17_BOVIN Computationally mapped isoform of RCC1 and BTB domain-containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18270135, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086612.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086612.1" } ] } }, { "isoform_ac": "A0AAA9T079-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9T079-1", "sequence": { "sequence": "MVSLALSVLKYCRLNLKCLLQIIYSSVKLRIDKSALHRDLELSSPRGSLTKGLHRTMEDYVEDELFLLYALYGKSGKMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 631, "header": "tr|A0AAA9T079-1|A0AAA9T079_BOVIN Computationally mapped isoform of RCC1 and BTB domain-containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18275461, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113639.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113639.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089914.1" } ] } }, { "isoform_ac": "A0AAA9TN04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#A0AAA9TN04-1", "sequence": { "sequence": "MVSLALSVLKYCRLNLKCLLMPVKDERGDLDVSKVVKPVQATLSSLKMLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 574, "header": "tr|A0AAA9TN04-1|A0AAA9TN04_BOVIN Computationally mapped isoform of RCC1 and BTB domain-containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=1 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18275461, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090563.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090563.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099736.1" } ] } }, { "isoform_ac": "F1MCW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5/entry#F1MCW5-1", "sequence": { "sequence": "MLDVGKWPIFSLCSEAELQLVRQACVFGSASNELLYTTIFVLGTNCCGCLGLGDVQSTIEPRRLDSLSGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNAGLVPYHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQSKVVVNIACGQMCSMAVVNTGEVFVWGYNGNGQLGLGSSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVTLPHLTHFSSTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPNTADLKFLVDGKYIYVHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN", "length": 523, "header": "tr|F1MCW5-1|A0AAA9S5V5_BOVIN Computationally mapped isoform of RCC1 and BTB domain containing protein 2 OS=Bos taurus OX=9913 GN=RCBTB2 PE=4 SV=3 CANONICAL=A0AAA9S5V5-1" }, "locus": { "chromosome": "12", "start_pos": 18264101, "end_pos": 18242797, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008733.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008733.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008733.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008733.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 495, "start_aa": "Thr", "end_pos": 495, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr495", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V5" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 588, "end_pos": 651, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 495 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 327, "end_pos": 329 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 373, "end_pos": 375 }, { "start_pos": 487, "end_pos": 489 }, { "start_pos": 490, "end_pos": 492 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7V4-1", "uniprot_ac": "A0AAA9S7V4", "uniprot_id": "A0AAA9S7V4_BOVIN", "mass": { "chemical_mass": 113906.0, "monoisotopic_mass": 113906.0 }, "refseq": { "ac": "XP_059733653", "name": "histone deacetylase complex subunit SAP130 isoform X9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733653" }, "gene_names": [ { "name": "SAP130", "type": "recommended", "evidence": [ { "id": "A0AAA9S7V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ] }, { "name": "SAP130", "type": "synonym", "evidence": [ { "id": "XP_059733653", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733653" } ] } ], "protein_names": [ { "name": "Sin3A associated protein 130", "type": "synonym", "evidence": [ { "id": "A0AAA9S7V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4/entry#names_and_taxonomy" } ] }, { "name": "histone deacetylase complex subunit SAP130 isoform X9", "type": "synonym", "evidence": [ { "id": "XP_059733653", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733653" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAP130", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4", "locus": { "chromosome": "2", "start_pos": 4530866, "end_pos": 4453860, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006003", "url": "https://www.ensembl.org/id/ENSBTAG00000006003" } ] } } ], "crossref": [ { "id": "A0AAA9S7V4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7V4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006003", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006003", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535754", "url": "https://www.ncbi.nlm.nih.gov/gene/535754", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535754", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535754", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13497", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13497", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13497:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13497:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059733653", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733653", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVU7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVU7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7V4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL80", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL80-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZQ1", "url": "https://www.uniprot.org/uniprotkb/F1MZQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZQ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MZQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPPRPSQPGEVESGGAGGGRRLQVEMSSQQFPRLGTPSTGLSQAPSQIANSGSAGLINPAATVNDESSRDAEVAAREHMGSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASGTPVTVAAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSALSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAAAQPAVQHIIHQPIQSRPPVTTSNTIPPAVVATVSATRAQSPVITTTAAHATDSTLSRPTLSLQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPIGTQGIHSATPISTQGLQPAPIGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSVSTNAPAQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSGSPRPAGAKPKSEIHVSMATPVTVSMETMSSQNSDQPTIAVPPTTQQPPPAIPTMIAAASPPSQPAVALPTIPGAVPITPPITTIAAAPPPSAAVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTMSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV", "length": 1083, "header": "tr|A0AAA9S7V4-1|A0AAA9S7V4_BOVIN Isoform 1 of Sin3A associated protein 130 OS=Bos taurus OX=9913 GN=SAP130 PE=3 SV=1 CANONICAL=A0AAA9S7V4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4/entry#A0A3Q1LVU7-1", "sequence": { "sequence": "MSSQQFPRLGTPSTGLSQAPSQIANSGSAGLINPAATVNDESSRDAEVAAREHMGSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASGTPVTVAAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSALSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAAAQPAVQHIIHQPIQSRPPVTTSNTIPPAVVATVSATRAQSPVITTTAAHATDSTLSRPTLSLQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPIGTQGIHSATPISTQGLQPAPIGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSVSTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETMSSQNSDQPTIAVPPTTQQPPPAIPTMIAAASPPSQPAVALPTIPGAVPITPPITTIAAAPPPSAAVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTMSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV", "length": 1022, "header": "tr|A0A3Q1LVU7-1|A0AAA9S7V4_BOVIN Computationally mapped isoform of Sin3A associated protein 130 OS=Bos taurus OX=9913 GN=SAP130 PE=3 SV=3 CANONICAL=A0AAA9S7V4-1" }, "locus": { "chromosome": "2", "start_pos": 4530091, "end_pos": 4454880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079116.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079116.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059474.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059474.3" } ] } }, { "isoform_ac": "A0AAA9S7V4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4/entry#A0AAA9S7V4-1", "sequence": { "sequence": "MGPPRPSQPGEVESGGAGGGRRLQVEMSSQQFPRLGTPSTGLSQAPSQIANSGSAGLINPAATVNDESSRDAEVAAREHMGSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASGTPVTVAAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSALSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAAAQPAVQHIIHQPIQSRPPVTTSNTIPPAVVATVSATRAQSPVITTTAAHATDSTLSRPTLSLQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPIGTQGIHSATPISTQGLQPAPIGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSVSTNAPAQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSGSPRPAGAKPKSEIHVSMATPVTVSMETMSSQNSDQPTIAVPPTTQQPPPAIPTMIAAASPPSQPAVALPTIPGAVPITPPITTIAAAPPPSAAVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTMSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV", "length": 1083, "header": "tr|A0AAA9S7V4-1|A0AAA9S7V4_BOVIN Isoform 1 of Sin3A associated protein 130 OS=Bos taurus OX=9913 GN=SAP130 PE=3 SV=1 CANONICAL=A0AAA9S7V4-1" }, "locus": { "chromosome": "2", "start_pos": 4530091, "end_pos": 4454009, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118344.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118344.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079385.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079385.1" } ] } }, { "isoform_ac": "A0AAA9SQQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4/entry#A0AAA9SQQ9-1", "sequence": { "sequence": "MKSHTFNDESSRDAEVAAREHMGSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASGTPVTVAAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSALSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAAAQPAVQHIIHQPIQSRPPVTTSNTIPPAVVATVSATRAQSPVITTTAAHATDSTLSRPTLSLQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPIGTQGIHSATPISTQGLQPAPIGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSVSTNAPAQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSGSPRPAGAKPKSEIHVSMATPVTVSMETMSSQNSDQPTIAVPPTTQQPPPAIPTMIAAASPPSQPAVALPTIPGAVPITPPITTIAAAPPPSAAVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTMSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV", "length": 1025, "header": "tr|A0AAA9SQQ9-1|A0AAA9SQQ9_BOVIN Computationally mapped isoform of Sin3A associated protein 130 OS=Bos taurus OX=9913 GN=SAP130 PE=3 SV=1 CANONICAL=A0AAA9S7V4-1" }, "locus": { "chromosome": "2", "start_pos": 4530091, "end_pos": 4462318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106246.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106246.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086289.1" } ] } }, { "isoform_ac": "A0ABI0NL80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4/entry#A0ABI0NL80-1", "sequence": { "sequence": "MSSQQFPRLGTPSTGLSQAPSQIANSGSAGLINPAATVNDESSRDAEVAAREHMGSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASGTPVTVAAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSALSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAAAQPAVQHIIHQPIQSRPPVTTSNTIPPAVVATVSATRAQSPVITTTAAHATDSTLSRPTLSLQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQVKPEKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPIGTQGIHSATPISTQGLQPAPIGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSVSTNAPAQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSGSPRPAGAKPKSEIHVSMATPVTVSMETMSSQNSDQPTIAVPPTTQQPPPAIPTMIAAASPPSQPAVALPTIPGAVPITPPITTIAAAPPPSAAVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTMSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV", "length": 1061, "header": "tr|A0ABI0NL80-1|A0ABI0NL80_BOVIN Computationally mapped isoform of Sin3A associated protein 130 OS=Bos taurus OX=9913 GN=SAP130 PE=3 SV=1 CANONICAL=A0AAA9S7V4-1" }, "locus": { "chromosome": "2", "start_pos": 4530091, "end_pos": 4454880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149496.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149496.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105738.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105738.1" } ] } }, { "isoform_ac": "F1MZQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4/entry#F1MZQ1-1", "sequence": { "sequence": "MSSQQFPRLGTPSTGLSQAPSQIANSGSAGLINPAATVNDESSRDAEVAAREHMGSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASGTPVTVAAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSALSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAAAAQPAVQHIIHQPIQSRPPVTTSNTIPPAVVATVSATRAQSPVITTTAAHATDSTLSRPTLSLQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQVKPEKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPIGTQGIHSATPISTQGLQPAPIGTQQPQPEGKTSVVLADGATIVANPISNPFSAAPAATTVVQTHSQSVSTNAPAQGSSPRPSILRKKPATDGMAVRKTLIPPQPPDVASPRVESSMRSTSGSPRPAGAKPKSEIHVSMATPVTVSMETMSSQNSDQPTIAVPPTTQQPPPAIPTMIAAASPPSQPAVALPTIPGAVPITPPITTIAAAPPPSAAVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTMSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV", "length": 1060, "header": "tr|F1MZQ1-1|A0AAA9S7V4_BOVIN Computationally mapped isoform of Sin3A associated protein 130 OS=Bos taurus OX=9913 GN=SAP130 PE=3 SV=5 CANONICAL=A0AAA9S7V4-1" }, "locus": { "chromosome": "2", "start_pos": 4530091, "end_pos": 4454880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050755.6", "url": "https://www.ensembl.org/id/ENSBTAT00000050755.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047415.6", "url": "https://www.ensembl.org/id/ENSBTAP00000047415.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 786, "start_aa": "Thr", "end_pos": 786, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr786", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535754", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535754", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "pmid": "" }, { "name": "Sin3-type complex", "id": "GO:0070822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070822", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1068, "end_pos": 1070, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" }, { "start_pos": 889, "end_pos": 891, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V4" }, { "id": "PF16014", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone deacetylase complex subunit SAP130 C-terminal", "eco_id": "ECO_0000259", "start_pos": 661, "end_pos": 1066, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 786 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1068, "end_pos": 1070 }, { "start_pos": 853, "end_pos": 855 }, { "start_pos": 889, "end_pos": 891 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S636-1", "uniprot_ac": "A0AAA9S636", "uniprot_id": "A0AAA9S636_BOVIN", "mass": { "chemical_mass": 57621.0, "monoisotopic_mass": 57621.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "C2H2-type domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX1#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636", "locus": {} } ], "crossref": [ { "id": "A0AAA9S636", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S636", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050830", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050830", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LWX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWX1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S636-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPKGKVKARRPLRVVPWRAAQRWWPWPRTFSEAGTGARCGEERKDGSEARESGLSRWLGTPWEVASAESCRKSPRGFPPLSSRFLSSDCGSRLTLGLLGERRDASDRMNSKLPISKEKNCPEELPGANLQVGNMGQVTGQSEETLEHRQKNACCPQTSSSRGDPPEEKGQGSSPGEGREMQGSSCGGKQDLVVRQPSFKDTERRFVCQQCGKSFTRNSSLVKHQVIHSGVKPFKCGECGRHFQHKFSLTEHQRTHSGEKHYTCGECGKTFTRGSSLMKHQIIHTGEKPYGCDECGKRFGRKFTLTEHQRIHSGERPYSCDVCGKAFTRSSNLIEHQRTHSSEKPYTCSQCPKAFKGISQLIHHQRVHKEEKPFMCKECGKAFRGHSGLSQHRPVHTGEKPYECSECGKTFSRRFNLLNHQIVHIEKRPYVCQECGKAFHHSSAFLKHWRTHSRPQPCACGHCDDCNQASKEKPQPDQQPRIHQNLLEGNNSRDGPGLPGPPKSHCRVPPRE", "length": 512, "header": "tr|A0AAA9S636-1|A0AAA9S636_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S636-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636/entry#A0A3Q1LWX1-1", "sequence": { "sequence": "MPPGFPPCSRKPEEDEGERPRQLFTRKMIGRETHERRLFATVSTSGDRMNSKLPISKEKNCPEELPGANLQVGNMGQVTGQSEETLEHRQKNACCPQTSSSRGDPPEEKGQGSSPGEGREMQGSSCGGKQDLVVRQPSFKDTERRFVCQQCGKSFTRNSSLVKHQVIHSGVKPFKCGECGRHFQHKFSLTEHQRTHSGEKHYTCGECGKTFTRGSSLMKHQIIHTGEKPYGCDECGKRFGRKFTLTEHQRIHSGERPYSCDVCGKAFTRSSNLIEHQRTHSSEKPYTCSQCPKAFKGISQLIHHQRVHKEEKPFMCKECGKAFRGHSGLSQHRPVHTGEKPYECSECGKTFSRRFNLLNHQIVHIEKRPYVCQECGKAFHHSSAFLKHWRTHSRPQPCACGHCDDCNQASKEKPQPDQQPRIHQNLLEGNNSRDGPGLPGPPKSHCRVPPRE", "length": 452, "header": "tr|A0A3Q1LWX1-1|A0AAA9S636_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9S636-1" }, "locus": { "chromosome": "X", "start_pos": 36669143, "end_pos": 36650283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078222.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078222.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059971.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059971.2" } ] } }, { "isoform_ac": "A0AAA9S636-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636/entry#A0AAA9S636-1", "sequence": { "sequence": "MAPKGKVKARRPLRVVPWRAAQRWWPWPRTFSEAGTGARCGEERKDGSEARESGLSRWLGTPWEVASAESCRKSPRGFPPLSSRFLSSDCGSRLTLGLLGERRDASDRMNSKLPISKEKNCPEELPGANLQVGNMGQVTGQSEETLEHRQKNACCPQTSSSRGDPPEEKGQGSSPGEGREMQGSSCGGKQDLVVRQPSFKDTERRFVCQQCGKSFTRNSSLVKHQVIHSGVKPFKCGECGRHFQHKFSLTEHQRTHSGEKHYTCGECGKTFTRGSSLMKHQIIHTGEKPYGCDECGKRFGRKFTLTEHQRIHSGERPYSCDVCGKAFTRSSNLIEHQRTHSSEKPYTCSQCPKAFKGISQLIHHQRVHKEEKPFMCKECGKAFRGHSGLSQHRPVHTGEKPYECSECGKTFSRRFNLLNHQIVHIEKRPYVCQECGKAFHHSSAFLKHWRTHSRPQPCACGHCDDCNQASKEKPQPDQQPRIHQNLLEGNNSRDGPGLPGPPKSHCRVPPRE", "length": 512, "header": "tr|A0AAA9S636-1|A0AAA9S636_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S636-1" }, "locus": { "chromosome": "X", "start_pos": 36669143, "end_pos": 36659281, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080682.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" }, { "name": "positive regulation of biosynthetic process", "id": "GO:0009891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S636", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S636" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 206, "end_pos": 233, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 218, "end_pos": 220 }, { "start_pos": 490, "end_pos": 492 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7Y2-1", "uniprot_ac": "A0AAA9S7Y2", "uniprot_id": "A0AAA9S7Y2_BOVIN", "mass": { "chemical_mass": 74687.0, "monoisotopic_mass": 74687.0 }, "refseq": { "ac": "XP_059733287", "name": "zinc finger protein 256 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733287" }, "gene_names": [ { "name": "LOC789960", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ] }, { "name": "LOC789960", "type": "synonym", "evidence": [ { "id": "XP_059733287", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733287" } ] } ], "protein_names": [ { "name": "Zinc finger protein 256-like", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 256 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059733287", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733287" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC789960", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7Y2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7Y2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040442", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040442", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789960", "url": "https://www.ncbi.nlm.nih.gov/gene/789960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059733287", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733287", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6C7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6C7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAALGDPPQGSVTFPDVAVYFSWEEWRLLDEAQRRLYLDVMLENYALISSLGCCCGTENAEAPSERITSLQVSQARTPKAALSTQKMNPCEICGPVFRLAEHHETQHIQKLLRCGACVKHFCFSANFQQHPEQHMGEKTLRSSVDKASFVKSCSFHVSQKPFTCRDFEKDFLTIMVHLQQQAVKKPNIVTQCESTSNVRKSHHTWEECKKALSPPRTFVQDEGVRTGRPCFVCSECGKAFRYKSSFVVHQRVHAGEWIHVCGESGKSFRQSSSLCQHQSIQTGAMQYKCSKCGKFLSHKSVLISPHTWHSGENSYVCSECSKSFTSSSALTYHQRSHTGERPYECSDCEKSFVSRPALRYHQRSHTGERPYACSQCGKTFTTSSNLHYHQRVHTGERPYECSECGKSFNNRWVLIQHQRVHTGERPYECTECGKLFKYGSQLNQHQKAHTGEKPFKCTECGKSFNNRWTLIQHWRVHTGERPFECSECGKSFNRRNNLILHQRIHTGERPYVCNECGKSFTFSSSLRYHQRAHTGERPYECSECGKSFISRSDLHYHQRVHSGERPYECSECGKSFIQRNNLIIHQRIHTGERPYECSECGKSFTCSSTLHYHQRVHTGERPYVCSECGKSFITTSKLRCHQKGHIGERP", "length": 651, "header": "tr|A0AAA9S7Y2-1|A0AAA9S7Y2_BOVIN Isoform 1 of Zinc finger protein 256-like OS=Bos taurus OX=9913 GN=LOC789960 PE=3 SV=1 CANONICAL=A0AAA9S7Y2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2/entry#A0A3Q1M6C7-1", "sequence": { "sequence": "MLENYALISSLGCCCGTENAEAPSERITSLQVSQARTPKAALSTQKMNPCEICGPVFRLAEHHETQHIQKLLRCGACVKHFCFSANFQQHPEQHMGEKTLRSSVDKASFVKSCSFHVSQKPFTCRDFEKDFLTIMVHLQQQAVKKPNIVTQCESTSNVRKSHHTWEECKKALSPPRTFVQDEGVRTGRPCFVCSECGKAFRYKSSFVVHQRVHAGEWIHVCGESGKSFRQSSSLCQHQSIQTGAMQYKCSKCGKFLSHKSVLISPHTWHSGENSYVCSECSKSFTSSSALTYHQRSHTGERPYECSDCEKSFVSRPALRYHQRSHTGERPYACSQCGKTFTTSSNLHYHQRVHTGERPYECSECGKSFNNRWVLIQHQRVHTGERPYECTECGKLFKYGSQLNQHQKAHTGEKPFKCTECGKSFNNRWTLIQHWRVHTGERPFECSECGKSFNRRNNLILHQRIHTGERPYVCNECGKSFTFSSSLRYHQRAHTGERPYECSECGKSFISRSDLHYHQRVHSGERPYECSECGKSFIQRNNLIIHQRIHTGERPYECSECGKSFTCSSTLHYHQRVHTGERPYVCSECGKSFITTSKLRCHQKGHIGERP", "length": 610, "header": "tr|A0A3Q1M6C7-1|A0AAA9S7Y2_BOVIN Computationally mapped isoform of Zinc finger protein 256-like OS=Bos taurus OX=9913 GN=LOC789960 PE=3 SV=2 CANONICAL=A0AAA9S7Y2-1" }, "locus": { "chromosome": "18", "start_pos": 65367226, "end_pos": 65360759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087271.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087271.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065531.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065531.2" } ] } }, { "isoform_ac": "A0AAA9S7Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2/entry#A0AAA9S7Y2-1", "sequence": { "sequence": "MAAALGDPPQGSVTFPDVAVYFSWEEWRLLDEAQRRLYLDVMLENYALISSLGCCCGTENAEAPSERITSLQVSQARTPKAALSTQKMNPCEICGPVFRLAEHHETQHIQKLLRCGACVKHFCFSANFQQHPEQHMGEKTLRSSVDKASFVKSCSFHVSQKPFTCRDFEKDFLTIMVHLQQQAVKKPNIVTQCESTSNVRKSHHTWEECKKALSPPRTFVQDEGVRTGRPCFVCSECGKAFRYKSSFVVHQRVHAGEWIHVCGESGKSFRQSSSLCQHQSIQTGAMQYKCSKCGKFLSHKSVLISPHTWHSGENSYVCSECSKSFTSSSALTYHQRSHTGERPYECSDCEKSFVSRPALRYHQRSHTGERPYACSQCGKTFTTSSNLHYHQRVHTGERPYECSECGKSFNNRWVLIQHQRVHTGERPYECTECGKLFKYGSQLNQHQKAHTGEKPFKCTECGKSFNNRWTLIQHWRVHTGERPFECSECGKSFNRRNNLILHQRIHTGERPYVCNECGKSFTFSSSLRYHQRAHTGERPYECSECGKSFISRSDLHYHQRVHSGERPYECSECGKSFIQRNNLIIHQRIHTGERPYECSECGKSFTCSSTLHYHQRVHTGERPYVCSECGKSFITTSKLRCHQKGHIGERP", "length": 651, "header": "tr|A0AAA9S7Y2-1|A0AAA9S7Y2_BOVIN Isoform 1 of Zinc finger protein 256-like OS=Bos taurus OX=9913 GN=LOC789960 PE=3 SV=1 CANONICAL=A0AAA9S7Y2-1" }, "locus": { "chromosome": "18", "start_pos": 65367226, "end_pos": 65356833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125321.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125321.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079423.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 140, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S7Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 90, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6U4-1", "uniprot_ac": "A0AAA9S6U4", "uniprot_id": "A0AAA9S6U4_BOVIN", "mass": { "chemical_mass": 19737.0, "monoisotopic_mass": 19737.0 }, "refseq": { "ac": "XP_010810411", "name": "putative uncharacterized protein C8orf89 homolog isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810411" }, "gene_names": [ { "name": "C14H8orf89", "type": "recommended", "evidence": [ { "id": "A0AAA9S6U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4" } ] }, { "name": "C14H8orf89", "type": "synonym", "evidence": [ { "id": "XP_010810411", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810411" } ] } ], "protein_names": [ { "name": "Chromosome 14 C8orf89 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9S6U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4/entry#names_and_taxonomy" } ] }, { "name": "putative uncharacterized protein C8orf89 homolog isoform X3", "type": "synonym", "evidence": [ { "id": "XP_010810411", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810411" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C14H8orf89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4", "locus": { "chromosome": "14", "start_pos": 36588318, "end_pos": 36618694, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049035", "url": "https://www.ensembl.org/id/ENSBTAG00000049035" } ] } } ], "crossref": [ { "id": "A0AAA9S6U4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6U4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049035", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049035", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100848558", "url": "https://www.ncbi.nlm.nih.gov/gene/100848558", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848558", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848558", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTMVPLQ", "url": "https://omabrowser.org/oma/group/CTMVPLQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PF17690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010810411", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810411", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M872", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M872", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M872-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M872-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U103", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U103", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U103-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U103-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVLSPEIKCEPSNVTRNTLGGGFLFESSWRKAVLETQKMRKEYTTAFGLEEFKECVKMPYLPGLQNCQKSVSSTPLEFRRRLLHADTEMPPVRLKKTKPTCTVTPLQEKSKGLLRHCNSPSINFGSGFSDPLAGASSQYLQRLSNMAVLEYDTIRQETSKKSKKSKKRELRDC", "length": 174, "header": "tr|A0AAA9S6U4-1|A0AAA9S6U4_BOVIN Isoform 1 of Chromosome 14 C8orf89 homolog OS=Bos taurus OX=9913 GN=C14H8orf89 PE=4 SV=1 CANONICAL=A0AAA9S6U4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M872-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4/entry#A0A3Q1M872-1", "sequence": { "sequence": "MPVLSPEIKCEPSNVTRNTLGGGFLFESSWRKAVLETQKMRKEYTTAFGLEEFKECVKMPYLPGLQNCQKSVSSTPLEFRRRLLHADTEMPPVRLKKTKPTCTVTPLQEKSKGSGFSDPLAGASSQYLQRLSNMAVLEYDTIRQETSKKSKKSKKRELRDC", "length": 161, "header": "tr|A0A3Q1M872-1|A0AAA9S6U4_BOVIN Computationally mapped isoform of Chromosome 14 C8orf89 homolog OS=Bos taurus OX=9913 GN=C14H8orf89 PE=4 SV=1 CANONICAL=A0AAA9S6U4-1" }, "locus": { "chromosome": "14", "start_pos": 36605837, "end_pos": 36588570, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083748.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083748.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066302.1" } ] } }, { "isoform_ac": "A0AAA9S6U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4/entry#A0AAA9S6U4-1", "sequence": { "sequence": "MPVLSPEIKCEPSNVTRNTLGGGFLFESSWRKAVLETQKMRKEYTTAFGLEEFKECVKMPYLPGLQNCQKSVSSTPLEFRRRLLHADTEMPPVRLKKTKPTCTVTPLQEKSKGLLRHCNSPSINFGSGFSDPLAGASSQYLQRLSNMAVLEYDTIRQETSKKSKKSKKRELRDC", "length": 174, "header": "tr|A0AAA9S6U4-1|A0AAA9S6U4_BOVIN Isoform 1 of Chromosome 14 C8orf89 homolog OS=Bos taurus OX=9913 GN=C14H8orf89 PE=4 SV=1 CANONICAL=A0AAA9S6U4-1" }, "locus": { "chromosome": "14", "start_pos": 36605837, "end_pos": 36588570, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111778.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111778.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080905.1" } ] } }, { "isoform_ac": "A0AAA9U103-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6U4/entry#A0AAA9U103-1", "sequence": { "sequence": "MPVLSPEIKCEPSNVTRNTLGGGFLFESSWRKAVLETQKMRKEYTTAFGLEEFKECVKMPYLPGLQNCQKSVSSTPLEFRRRLLHADTEMPPVRFWLQR", "length": 99, "header": "tr|A0AAA9U103-1|A0AAA9U103_BOVIN Computationally mapped isoform of Chromosome 14 C8orf89 homolog OS=Bos taurus OX=9913 GN=C14H8orf89 PE=4 SV=1 CANONICAL=A0AAA9S6U4-1" }, "locus": { "chromosome": "14", "start_pos": 36605837, "end_pos": 36588700, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130063.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130063.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102825.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848558", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848558", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F6QJK4-1", "protein_name": "RIKEN cDNA 4930444P10 gene", "gene_name": "4930444P10Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMLSPEIKFETSNATRSNLDNCFLFESSWRKAVLETQKMRKAFGLEEPKECLKMPYLPELSKSSSSSSLEAHKRLLHTDAEIPPIRIKKTKESCSMAAFQEKSKGSVFSDPFTGAPSDFLQRLSRMAILEYDTIRQETHKKLRRGKKRDLRDC", "length": 154 }, "evidence": [ { "id": "A0AAA9S6U4", "url": "https://omabrowser.org/oma/group/A0AAA9S6U4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0R8B2-1", "protein_name": "Similar to human chromosome 8 open reading frame 89", "gene_name": "C5h8orf89", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSMLSPEIKFETSNVTRSSMDNCFLFESSWRKAVLETQKMRKAFGLEEPKECLKMPYLPELSKSLSSSPLEAHKRLLHTEAEIPPIRIKKTKESCSMAALQEKSKGSVFSDPFTGAPSDFLQRLSKMAILEYDTVRQETHKKLRRGKKRDLRDC", "length": 154 }, "evidence": [ { "id": "A0AAA9S6U4", "url": "https://omabrowser.org/oma/group/A0AAA9S6U4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0DMQ9-1", "protein_name": "Putative uncharacterized protein C8orf89", "gene_name": "C8orf89", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVLSPEIKCETSKFTRSSFGSCLIFESSWKKAVLETQKIKKEYTTAFGLEELKECIKMPYLPGLQSCQKSVSSTPLEVPKRLPRADAEVSAVRLKKTKETCSVAPLWEKSKGSGFSDPLTGAPSQYLERLSKIAILEYDTIRQETTTKSKKSKKRDLRDR", "length": 161 }, "evidence": [ { "id": "A0AAA9S6U4", "url": "https://omabrowser.org/oma/group/A0AAA9S6U4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9B7-1", "uniprot_ac": "A0AAA9S9B7", "uniprot_id": "A0AAA9S9B7_BOVIN", "mass": { "chemical_mass": 46183.0, "monoisotopic_mass": 46183.0 }, "refseq": {}, "gene_names": [ { "name": "GARIN2", "type": "recommended", "evidence": [ { "id": "A0AAA9S9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7" } ] } ], "protein_names": [ { "name": "Golgi associated RAB2 interactor family member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GARIN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7", "locus": { "chromosome": "10", "start_pos": 79149489, "end_pos": 79106952, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010239", "url": "https://www.ensembl.org/id/ENSBTAG00000010239" } ] } } ], "crossref": [ { "id": "A0AAA9S9B7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9B7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010239", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010239", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618905", "url": "https://www.ncbi.nlm.nih.gov/gene/618905", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22574:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22574:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12480", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12480", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M9N0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9N0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9B7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2V1", "url": "https://www.uniprot.org/uniprotkb/F1N2V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2V1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2V1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSVCASSSLAFRMMYSIYFSSGHVWI", "length": 414, "header": "tr|A0AAA9S9B7-1|A0AAA9S9B7_BOVIN Isoform 1 of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=1 CANONICAL=A0AAA9S9B7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0A3Q1M9N0-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSDKCKLLN", "length": 397, "header": "tr|A0A3Q1M9N0-1|A0AAA9S9B7_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=2 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79142107, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066713.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066713.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067276.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067276.2" } ] } }, { "isoform_ac": "A0A3Q1MP23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0A3Q1MP23-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSGLYSFSIFPLICISFPFATLL", "length": 411, "header": "tr|A0A3Q1MP23-1|A0AAA9S9B7_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=2 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79139003, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070799.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070799.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073644.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073644.2" } ] } }, { "isoform_ac": "A0AAA9RXH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0AAA9RXH9-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRYVKQGDCML", "length": 390, "header": "tr|A0AAA9RXH9-1|A0AAA9S9B7_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=1 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79127968, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091757.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091757.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075909.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075909.1" } ] } }, { "isoform_ac": "A0AAA9S9B7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0AAA9S9B7-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSVCASSSLAFRMMYSIYFSSGHVWI", "length": 414, "header": "tr|A0AAA9S9B7-1|A0AAA9S9B7_BOVIN Isoform 1 of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=1 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79149425, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129037.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129037.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081882.1" } ] } }, { "isoform_ac": "A0AAA9SPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0AAA9SPW0-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKKEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSGLYSFSIFPLICISFPFATLL", "length": 378, "header": "tr|A0AAA9SPW0-1|A0AAA9SPW0_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=1 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79139003, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131001.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131001.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086027.1" } ] } }, { "isoform_ac": "A0AAA9TIB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0AAA9TIB5-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPSSVQSLSRVRLFVTP", "length": 395, "header": "tr|A0AAA9TIB5-1|A0AAA9TIB5_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=1 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79128281, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105206.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105206.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096850.1" } ] } }, { "isoform_ac": "A0AAA9TY15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#A0AAA9TY15-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLEQEN", "length": 147, "header": "tr|A0AAA9TY15-1|A0AAA9TY15_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=1 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79136155, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112680.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112680.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102091.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102091.1" } ] } }, { "isoform_ac": "F1N2V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7/entry#F1N2V1-1", "sequence": { "sequence": "MKKSNRKSPTRIDEKDDICVPDSKDPGELQNMLNGGEYAPFVSPPILESNFIQVNRRGESIYLHNRANWVTVGICSSNPTTKTPNVMLLAHLTPTAQKDSEPLFTSLLTSPSPENLVLTRFLPLQFVTLSVHDAENMRIKVKLVSGRAYYLQLCAPACKQEALFCQWVELISLLNKEKAKASKVSEVSSLSEITNSTDITGSVDIMDIAAFPAIQTSHLSTCSDPNNDVESVDFSEFTDITDVTDVTDIPENEVTEAPDINIVTEVTEVTDICGVTASSGVRVVFENDDILKAKQEEKEKMENILKSGCLRDTKSKNEFRESPKRVTISNLALTFEGERCFQTTLTPEEDETEKSKEMSDRPREIRTMDSESTTLKAEEPRSRRTDSDTSDFQ", "length": 393, "header": "tr|F1N2V1-1|F1N2V1_BOVIN Computationally mapped isoform of Golgi associated RAB2 interactor family member 2 OS=Bos taurus OX=9913 GN=GARIN2 PE=3 SV=2 CANONICAL=A0AAA9S9B7-1" }, "locus": { "chromosome": "10", "start_pos": 79142051, "end_pos": 79117701, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043336.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043336.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040913.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040913.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 71, "start_aa": "Thr", "end_pos": 71, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr71", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sperm head", "id": "GO:0061827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061827", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B7" }, { "id": "PF12480", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12480" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Golgi associated RAB2 interactor protein-like Rab2B-binding", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 184, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 71 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8I8-1", "uniprot_ac": "A0AAA9S8I8", "uniprot_id": "A0AAA9S8I8_BOVIN", "mass": { "chemical_mass": 25365.0, "monoisotopic_mass": 25365.0 }, "refseq": {}, "gene_names": [ { "name": "LRMDA", "type": "recommended", "evidence": [ { "id": "A0AAA9S8I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8" } ] } ], "protein_names": [ { "name": "Leucine-rich melanocyte differentiation-associated protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S8I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for melanocyte differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MAG1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAG1#function" }, { "database": "UniProtKB", "id": "ARBA00059627", "url": "https://www.uniprot.org/uniprotkb/ARBA00059627#function" }, { "database": "UniProtKB", "id": "A0AAA9S8I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRMDA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8", "locus": { "chromosome": "28", "start_pos": 32325849, "end_pos": 31166902, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052007", "url": "https://www.ensembl.org/id/ENSBTAG00000052007" } ] } } ], "crossref": [ { "id": "A0AAA9S8I8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8I8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052007", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052007", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAG1", "url": "https://www.orthodb.org/?gene=A0A3Q1MAG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46282:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46282:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MAG1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAG1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLVVSGTQVSYIGQDCREIPEHLGRDCGHFAKRLDLSFNLLRSLEGLSAFGSLEELILDNNLLGDDLVLPGLPRLHTLTLNKNQITDLEYLLDHLAEVTPALEYLSLLGNVACPNELVSLEKDEEDYKRYRCFVLHKLPNLKFLDAQKVTTQEREEALVRGAFMKVVKPKASSDSVAVSPKSRYTPLPSASRELTSHRGVLGKCRYVYYGKNSEGNRFIRDDQL", "length": 226, "header": "tr|A0AAA9S8I8-1|A0AAA9S8I8_BOVIN Isoform 1 of Leucine-rich melanocyte differentiation-associated protein OS=Bos taurus OX=9913 GN=LRMDA PE=4 SV=1 CANONICAL=A0AAA9S8I8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8/entry#A0A3Q1MAG1-1", "sequence": { "sequence": "MEKYLSLRGNHSSNKRSLEGLSAFGSLEELILDNNLLGDDLVLPGLPRLHTLTLNKNQITDLEYLLDHLAEVTPALEYLSLLGNVACPNELVSLEKDEEDYKRYRCFVLHKLPNLKFLDAQKVTTQEREEALVRGAFMKVVKPKASSDSVAVSPKSRYTPLPSASRELTSHRGVLGKCRYVYYGKNSEGNRFIRDDQL", "length": 198, "header": "tr|A0A3Q1MAG1-1|A0AAA9S8I8_BOVIN Computationally mapped isoform of Leucine-rich melanocyte differentiation-associated protein OS=Bos taurus OX=9913 GN=LRMDA PE=4 SV=2 CANONICAL=A0AAA9S8I8-1" }, "locus": { "chromosome": "28", "start_pos": 32325847, "end_pos": 31538185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082983.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082983.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067201.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067201.2" } ] } }, { "isoform_ac": "A0AAA9S8I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8/entry#A0AAA9S8I8-1", "sequence": { "sequence": "MAGLVVSGTQVSYIGQDCREIPEHLGRDCGHFAKRLDLSFNLLRSLEGLSAFGSLEELILDNNLLGDDLVLPGLPRLHTLTLNKNQITDLEYLLDHLAEVTPALEYLSLLGNVACPNELVSLEKDEEDYKRYRCFVLHKLPNLKFLDAQKVTTQEREEALVRGAFMKVVKPKASSDSVAVSPKSRYTPLPSASRELTSHRGVLGKCRYVYYGKNSEGNRFIRDDQL", "length": 226, "header": "tr|A0AAA9S8I8-1|A0AAA9S8I8_BOVIN Isoform 1 of Leucine-rich melanocyte differentiation-associated protein OS=Bos taurus OX=9913 GN=LRMDA PE=4 SV=1 CANONICAL=A0AAA9S8I8-1" }, "locus": { "chromosome": "28", "start_pos": 32325847, "end_pos": 31167101, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108106.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108106.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080241.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080241.1" } ] } }, { "isoform_ac": "A0AAA9SNU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8/entry#A0AAA9SNU5-1", "sequence": { "sequence": "MASSDSVAVSPKSRYTPLPSASRELTSHRGVLGKCRYVYYGKNSEGNRFIRDDQL", "length": 55, "header": "tr|A0AAA9SNU5-1|A0AAA9SNU5_BOVIN Computationally mapped isoform of Leucine rich melanocyte differentiation associated OS=Bos taurus OX=9913 GN=LRMDA PE=4 SV=1 CANONICAL=A0AAA9S8I8-1" }, "locus": { "chromosome": "28", "start_pos": 32325847, "end_pos": 32088539, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094124.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094124.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084548.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084548.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8I8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S823-1", "uniprot_ac": "A0AAA9S823", "uniprot_id": "A0AAA9S823_BOVIN", "mass": { "chemical_mass": 83452.0, "monoisotopic_mass": 83452.0 }, "refseq": {}, "gene_names": [ { "name": "TRIM6", "type": "recommended", "evidence": [ { "id": "A0AAA9S823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ] } ], "protein_names": [ { "name": "RING-type E3 ubiquitin transferase", "type": "recommended", "evidence": [ { "id": "A0AAA9S823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAA9S823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823", "locus": { "chromosome": "15", "start_pos": 47918096, "end_pos": 48059222, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048999", "url": "https://www.ensembl.org/id/ENSBTAG00000048999" } ] } } ], "crossref": [ { "id": "A0AAA9S823", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S823", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048999", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048999", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15823", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15823", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16591", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16591", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MEY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S823-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T926", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T926", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T926-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T926-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N541", "url": "https://www.uniprot.org/uniprotkb/F1N541", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N541-1", "url": "https://www.uniprot.org/uniprotkb/F1N541-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQHSQKKSPLCVLQSACPGSGLSHNCGFPIISDLSPNQHSPIPSSFIRMDRNSTRKGPIFFLFLGFQRGHSGWWAPEVRSLQKIMAFLSANNTAAVNNSDTRLAGCFLLGIPGLEDLHIWLSVPFCTMYAYPNPDMRSESQTEDNLQVPSLAFRVAEASPFAVQPVSGTAFLKLDAALERRTQRGAGQISSISSPRPRPRPFPPEPFCLGGGGSSCKSSALIQVTDCRIPNTRSTLEVRAGQAEARKVATMTSAVLVDIQDEVTCPICLELLTEPLSIDCGHSFCQACITADNKESMPGQEGQSRCPVCQTSYWLGNLRPNRHLANIAERLREVVVGSGKQLKVILCAHHGEKLQLFCEEDGKLICWLCERSQEHRGHHTFLMEEIAQEYQEKFQESLKKLRQEQQEAEKLAAVIREKRISWKNQMEPERHRIQKQFDHLRSILDKEEQRQLKKLEEEERRGLNIIAEAEVELVQQSQSLRELISDLEHRCQGSATELLQDVSDVAKRSEFWTLKKPEALPTKLKSMFRAPDLKKMLRVFRELTDVQSYWVDVTLNPHTANLNLVLSKNRRQVRFVGAQLSGSHLEEHYGCGVLGSQHFSSGKHYWEVDVAKKTDWILGVCSDSMGPAFSFNQFANNRNVYSRYQPQSGYWVIGLHHKHEYRAYEESSTSLLLSMTVPPRRVGVFLDYDAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVFPMTLRRPSS", "length": 737, "header": "tr|A0AAA9S823-1|A0AAA9S823_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM6 PE=3 SV=1 CANONICAL=A0AAA9S823-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823/entry#A0A3Q1MEY5-1", "sequence": { "sequence": "MDQRSCVPCSTAKKKYRYAYPNPDMRSESQTEDNLQVPSLAFRVAEASPFAVQPVSGTAFLKLDAALERRTQRGAGQISSISSPRPRPRPFPPEPFCLGGGGSSCKSSALIQVTDCRIPNTRSTLEVRAGQAEARKVATMTSAVLVDIQDEVTCPICLELLTEPLSIDCGHSFCQACITADNKESMPGQEGQSRCPVCQTSYWLGNLRPNRHLANIAERLREVVVGSGKQLKVILCAHHGEKLQLFCEEDGKLICWLCERSQEHRGHHTFLMEEIAQEYQEKFQESLKKLRQEQQEAEKLAAVIREKRISWKNQMEPERHRIQKQFDHLRSILDKEEQRQLKKLEEEERRGLNIIAEAEVELVQQSQSLRELISDLEHRCQGSATELLQDVSDVAKRSEFWTLKKPEALPTKLKSMFRAPDLKKMLRVFRELTDVQSYWVDVTLNPHTANLNLVLSKNRRQVRFVGAQLSGSHLEEHYGCGVLGSQHFSSGKHYWEVDVAKKTDWILGVCSDSMGPAFSFNQFANNRNVYSRYQPQSGYWVIGLHHKHEYRAYEESSTSLLLSMTVPPRRVGVFLDYDAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVFPMTLRRPSS", "length": 626, "header": "tr|A0A3Q1MEY5-1|A0AAA9S823_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM6 PE=3 SV=2 CANONICAL=A0AAA9S823-1" }, "locus": { "chromosome": "15", "start_pos": 48005552, "end_pos": 47918784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067371.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067371.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069071.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069071.2" } ] } }, { "isoform_ac": "A0AAA9S823-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823/entry#A0AAA9S823-1", "sequence": { "sequence": "MQHSQKKSPLCVLQSACPGSGLSHNCGFPIISDLSPNQHSPIPSSFIRMDRNSTRKGPIFFLFLGFQRGHSGWWAPEVRSLQKIMAFLSANNTAAVNNSDTRLAGCFLLGIPGLEDLHIWLSVPFCTMYAYPNPDMRSESQTEDNLQVPSLAFRVAEASPFAVQPVSGTAFLKLDAALERRTQRGAGQISSISSPRPRPRPFPPEPFCLGGGGSSCKSSALIQVTDCRIPNTRSTLEVRAGQAEARKVATMTSAVLVDIQDEVTCPICLELLTEPLSIDCGHSFCQACITADNKESMPGQEGQSRCPVCQTSYWLGNLRPNRHLANIAERLREVVVGSGKQLKVILCAHHGEKLQLFCEEDGKLICWLCERSQEHRGHHTFLMEEIAQEYQEKFQESLKKLRQEQQEAEKLAAVIREKRISWKNQMEPERHRIQKQFDHLRSILDKEEQRQLKKLEEEERRGLNIIAEAEVELVQQSQSLRELISDLEHRCQGSATELLQDVSDVAKRSEFWTLKKPEALPTKLKSMFRAPDLKKMLRVFRELTDVQSYWVDVTLNPHTANLNLVLSKNRRQVRFVGAQLSGSHLEEHYGCGVLGSQHFSSGKHYWEVDVAKKTDWILGVCSDSMGPAFSFNQFANNRNVYSRYQPQSGYWVIGLHHKHEYRAYEESSTSLLLSMTVPPRRVGVFLDYDAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVFPMTLRRPSS", "length": 737, "header": "tr|A0AAA9S823-1|A0AAA9S823_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM6 PE=3 SV=1 CANONICAL=A0AAA9S823-1" }, "locus": { "chromosome": "15", "start_pos": 48005529, "end_pos": 47918784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122341.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122341.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079475.1" } ] } }, { "isoform_ac": "A0AAA9T926-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823/entry#A0AAA9T926-1", "sequence": { "sequence": "MEYRYAYPNPDMRSESQTEDNLQVPSLAFRVAEASPFAVQPVSGTAFLKLDAALERRTQRGAGQISSISSPRPRPRPFPPEPFCLGGGGSSCKSSALIQVTDCRIPNTRSTLEVRAGQAEARKVATMTSAVLVDIQDEVTCPICLELLTEPLSIDCGHSFCQACITADNKESMPGQEGQSRCPVCQTSYWLGNLRPNRHLANIAERLREVVVGSGKQLKVILCAHHGEKLQLFCEEDGKLICWLCERSQEHRGHHTFLMEEIAQEYQEKFQESLKKLRQEQQEAEKLAAVIREKRISWKNQMEPERHRIQKQFDHLRSILDKEEQRQLKKLEEEERRGLNIIAEAEVELVQQSQSLRELISDLEHRCQGSATELLQDVSDVAKRSEFWTLKKPEALPTKLKSMFRAPDLKKMLRVFRVDVTLNPHTANLNLVLSKNRRQVRFVGAQLSGSHLEEHYGCGVLGSQHFSSGKHYWEVDVAKKTDWILGVCSDSMGPAFSFNQFANNRNVYSRYQPQSGYWVIGLHHKHEYRAYEESSTSLLLSMTVPPRRVGVFLDYDAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVFPMTLRRPSS", "length": 604, "header": "tr|A0AAA9T926-1|A0AAA9T926_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM6 PE=3 SV=1 CANONICAL=A0AAA9S823-1" }, "locus": { "chromosome": "15", "start_pos": 47937399, "end_pos": 47918784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134435.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134435.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093116.1" } ] } }, { "isoform_ac": "F1N541-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823/entry#F1N541-1", "sequence": { "sequence": "MTSAVLVDIQDEVTCPICLELLTEPLSIDCGHSFCQACITADNKESMPGQEGQSRCPVCQTSYWLGNLRPNRHLANIAERLREEDGKLICWLCERSQEHRGHHTFLMEEIAQEYQEKFQESLKKLRQEQQEAEKLAAVIREKRISWKNQMEPERHRIQKQFDHLRSILDKEEQRQLKKLEEEERRGLNIIAEAEVELVQQSQSLRELISDLEHRCQGSATELLQDVSDVAKRSEFWTLKKPEALPTKLKSMFRAPDLKKMLRVFRELTDVQSYWVDVTLNPHTANLNLVLSKNRRQVRFVGAQLSGSHLEEHYGCGVLGSQHFSSGKHYWEVDVAKKTDWILGVCSDSMGPAFSFNQFANNRNVYSRYQPQSGYWVIGLHHKHEYRAYEESSTSLLLSMTVPPRRVGVFLDYDAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVFPMTLRRPSS", "length": 461, "header": "tr|F1N541-1|F1N541_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM6 PE=3 SV=4 CANONICAL=A0AAA9S823-1" }, "locus": { "chromosome": "15", "start_pos": 47928125, "end_pos": 47918784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015712.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015712.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015712.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015712.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "protein tyrosine kinase binding", "id": "GO:1990782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990782", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "negative regulation of viral genome replication", "id": "GO:0045071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "positive regulation of defense response to virus by host", "id": "GO:0002230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "cellular response to interferon-beta", "id": "GO:0035458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "positive regulation of cytokine production involved in immune response", "id": "GO:0002720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002720", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "positive regulation of type I interferon-mediated signaling pathway", "id": "GO:0060340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "free ubiquitin chain polymerization", "id": "GO:0010994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010994", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "negative regulation of stem cell differentiation", "id": "GO:2000737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S823", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 342, "end_pos": 383, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 532, "end_pos": 737, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S823" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 265, "end_pos": 310, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 52, "end_pos": 54 }, { "start_pos": 697, "end_pos": 699 }, { "start_pos": 91, "end_pos": 93 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6H1-1", "uniprot_ac": "A0AAA9S6H1", "uniprot_id": "A0AAA9S6H1_BOVIN", "mass": { "chemical_mass": 15746.0, "monoisotopic_mass": 15746.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112445102", "type": "recommended", "evidence": [ { "id": "A0AAA9S6H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1" } ] } ], "protein_names": [ { "name": "L antigen family member 3", "type": "recommended", "evidence": [ { "id": "A0AAA9S6H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1#function" }, { "database": "UniProtKB", "id": "ARBA00053047", "url": "https://www.uniprot.org/uniprotkb/ARBA00053047#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112445102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1", "locus": {} } ], "crossref": [ { "id": "IPR015419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112445102", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445102", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31283", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31283", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31283:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31283:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09341", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09341", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQASGGGAGGAEDRDDQQSSRIPACQSGSGSAEGEAVRRAPQGRGGPGRGRAVMEAAVARPQGDTLRVPFQSPLEADMARRSLLPDAQRHQGLIRKEFAVNGSDLLVRWTADDLAFIRLSMNPFLDQLSLVIRNIRSLGLPPRQSRS", "length": 147, "header": "tr|A0AAA9S6H1-1|A0AAA9S6H1_BOVIN Isoform 1 of L antigen family member 3 OS=Bos taurus OX=9913 GN=LOC112445102 PE=3 SV=2 CANONICAL=A0AAA9S6H1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H1/entry#A0AAA9S6H1-1", "sequence": { "sequence": "MQASGGGAGGAEDRDDQQSSRIPACQSGSGSAEGEAVRRAPQGRGGPGRGRAVMEAAVARPQGDTLRVPFQSPLEADMARRSLLPDAQRHQGLIRKEFAVNGSDLLVRWTADDLAFIRLSMNPFLDQLSLVIRNIRSLGLPPRQSRS", "length": 147, "header": "tr|A0AAA9S6H1-1|A0AAA9S6H1_BOVIN Isoform 1 of L antigen family member 3 OS=Bos taurus OX=9913 GN=LOC112445102 PE=3 SV=2 CANONICAL=A0AAA9S6H1-1" }, "locus": { "chromosome": "NKLS02001861.1", "start_pos": 11287, "end_pos": 10267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122048.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122048.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092181.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092181.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112445102", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445102", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S661-1", "uniprot_ac": "A0AAA9S661", "uniprot_id": "A0AAA9S661_BOVIN", "mass": { "chemical_mass": 93669.0, "monoisotopic_mass": 93669.0 }, "refseq": { "ac": "XP_010811518", "name": "kinesin-associated protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811518" }, "gene_names": [ { "name": "KIFAP3", "type": "recommended", "evidence": [ { "id": "A0AAA9S661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ] }, { "name": "KIFAP3", "type": "synonym", "evidence": [ { "id": "XP_010811518", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811518" } ] } ], "protein_names": [ { "name": "Kinesin associated protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661/entry#names_and_taxonomy" } ] }, { "name": "kinesin-associated protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010811518", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811518" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIFAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661", "locus": { "chromosome": "16", "start_pos": 37552133, "end_pos": 37694664, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017727", "url": "https://www.ensembl.org/id/ENSBTAG00000017727" } ] } } ], "crossref": [ { "id": "A0AAA9S661", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S661", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017727", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017727", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518402", "url": "https://www.ncbi.nlm.nih.gov/gene/518402", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15605", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15605", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15605:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15605:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05804", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05804", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010811518", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811518", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S661-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLGAELTRAAVGGSEQLQCFGAQKWWEEPVASPRKVKGGNIDVHPSEKALIVQYEVEATILGETGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSTSGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNDTALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYSSDGLVASEGAMSPDFFNDYHLQNGDVVGQHSFAGSLGMDGFGQSVGILGRPATAYGFRPDEPYFYGCGSR", "length": 817, "header": "tr|A0AAA9S661-1|A0AAA9S661_BOVIN Isoform 1 of Kinesin associated protein 3 OS=Bos taurus OX=9913 GN=KIFAP3 PE=4 SV=1 CANONICAL=A0AAA9S661-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661/entry#A0A3Q1MPT0-1", "sequence": { "sequence": "MQGEDARYLKRKVKGGNIDVHPSEKALIVQYEVEATILGETGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSTSGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNDTALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYSSDGLVASEGAMSPDFFNDYHLQNGDVVGQHSFAGRFFQPKTKHLYIGLSELKRQSNLKKESRFVWTISSG", "length": 793, "header": "tr|A0A3Q1MPT0-1|A0AAA9S661_BOVIN Computationally mapped isoform of Kinesin associated protein 3 OS=Bos taurus OX=9913 GN=KIFAP3 PE=4 SV=2 CANONICAL=A0AAA9S661-1" }, "locus": { "chromosome": "16", "start_pos": 37694253, "end_pos": 37565700, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079510.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079510.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071670.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071670.2" } ] } }, { "isoform_ac": "A0AAA9S661-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661/entry#A0AAA9S661-1", "sequence": { "sequence": "MRLGAELTRAAVGGSEQLQCFGAQKWWEEPVASPRKVKGGNIDVHPSEKALIVQYEVEATILGETGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSTSGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNDTALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYSSDGLVASEGAMSPDFFNDYHLQNGDVVGQHSFAGSLGMDGFGQSVGILGRPATAYGFRPDEPYFYGCGSR", "length": 817, "header": "tr|A0AAA9S661-1|A0AAA9S661_BOVIN Isoform 1 of Kinesin associated protein 3 OS=Bos taurus OX=9913 GN=KIFAP3 PE=4 SV=1 CANONICAL=A0AAA9S661-1" }, "locus": { "chromosome": "16", "start_pos": 37694507, "end_pos": 37552492, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126474.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126474.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080697.1" } ] } }, { "isoform_ac": "A0AAA9THF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661/entry#A0AAA9THF4-1", "sequence": { "sequence": "MQGEDARYLKSIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSTSGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNDTALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYSSDGLVASEGAMSPDFFNDYHLQNGDVVGQHSFAGSLGMDGFGQSVGILGRPATAYGFRPDEPYFYGCGSR", "length": 749, "header": "tr|A0AAA9THF4-1|A0AAA9THF4_BOVIN Computationally mapped isoform of Kinesin associated protein 3 OS=Bos taurus OX=9913 GN=KIFAP3 PE=4 SV=1 CANONICAL=A0AAA9S661-1" }, "locus": { "chromosome": "16", "start_pos": 37694253, "end_pos": 37552492, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095885.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095885.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096301.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096301.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 16, "go_terms": [ { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "dendrite cytoplasm", "id": "GO:0032839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "kinesin II complex", "id": "GO:0016939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016939", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "periciliary membrane compartment", "id": "GO:1990075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990075", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "protein phosphatase binding", "id": "GO:0019903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" }, { "name": "intraciliary transport particle B binding", "id": "GO:0120170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "anterograde dendritic transport of neurotransmitter receptor complex", "id": "GO:0098971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098971", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S661" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 386, "end_pos": 388 }, { "start_pos": 394, "end_pos": 396 }, { "start_pos": 513, "end_pos": 515 }, { "start_pos": 554, "end_pos": 556 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9R3-1", "uniprot_ac": "A0AAA9S9R3", "uniprot_id": "A0AAA9S9R3_BOVIN", "mass": { "chemical_mass": 75250.0, "monoisotopic_mass": 75250.0 }, "refseq": {}, "gene_names": [ { "name": "TENT4B", "type": "recommended", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ] } ], "protein_names": [ { "name": "Terminal nucleotidyltransferase 4B", "type": "recommended", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.19", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] }, { "name": "Non-canonical poly(A) RNA polymerase PAPD5", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] }, { "name": "PAP-associated domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] }, { "name": "Terminal guanylyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] }, { "name": "Terminal uridylyltransferase 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] }, { "name": "Topoisomerase-related function protein 4-2", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TENT4B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3", "locus": { "chromosome": "18", "start_pos": 18646448, "end_pos": 18572163, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007942", "url": "https://www.ensembl.org/id/ENSBTAG00000007942" } ] } } ], "crossref": [ { "id": "A0AAA9S9R3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9R3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007942", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007942", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05402", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05402", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789894", "url": "https://www.ncbi.nlm.nih.gov/gene/789894", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MYRAPRA", "url": "https://omabrowser.org/oma/group/MYRAPRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23092:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23092:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03828", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03828", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "11332", "url": "https://www.rhea-db.org/rhea/11332", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MTJ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNP2", "url": "https://www.uniprot.org/uniprotkb/F1MNP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNP2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VRPHPASGARKLRLGGTRVRGALTPSGGASGGGGGGGSSTATGGSGSSTGSPSGAAPAPAPAGMYRSGERLLGGHAQPAEQRDFLPLETTNNNNNHHQPAAWARRAAAGPSASPSPSASPSPHSSTAVPAAEPADPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAPGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESISKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPSTGNRVGSQDVSLESSQTGGKMQSTQTTNTPNSTNKSQHGSTRLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKRKHKRDAPLSDLCR", "length": 696, "header": "tr|A0AAA9S9R3-1|A0AAA9S9R3_BOVIN Isoform 1 of Terminal nucleotidyltransferase 4B OS=Bos taurus OX=9913 GN=TENT4B PE=3 SV=2 CANONICAL=A0AAA9S9R3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#A0A3Q1MTJ5-1", "sequence": { "sequence": "MQIWETTQGLRNLYFNHHCHSSGGASGGGGGGGSSTATGGSGSSTGSPSGAAPAPAPAGMYRSGERLLGGHAQPAEQRDFLPLETTNNNNNHHQPAAWARRAAAGPSASPSPSASPSPHSSTAVPAAEPADPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAPGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESISKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPSTGNRVGSQDVSLESSQTGGKMQSTQTTNTPNSTNKSQHGSTRLFRSSSKGFQALPSVLRNADSCEVLEV", "length": 666, "header": "tr|A0A3Q1MTJ5-1|A0AAA9S9R3_BOVIN Computationally mapped isoform of Terminal nucleotidyltransferase 4B OS=Bos taurus OX=9913 GN=TENT4B PE=3 SV=1 CANONICAL=A0AAA9S9R3-1" }, "locus": { "chromosome": "18", "start_pos": 18645444, "end_pos": 18573043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066586.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066586.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057984.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057984.1" } ] } }, { "isoform_ac": "A0AAA9S9R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#A0AAA9S9R3-1", "sequence": { "sequence": "VRPHPASGARKLRLGGTRVRGALTPSGGASGGGGGGGSSTATGGSGSSTGSPSGAAPAPAPAGMYRSGERLLGGHAQPAEQRDFLPLETTNNNNNHHQPAAWARRAAAGPSASPSPSASPSPHSSTAVPAAEPADPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAPGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESISKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPSTGNRVGSQDVSLESSQTGGKMQSTQTTNTPNSTNKSQHGSTRLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKRKHKRDAPLSDLCR", "length": 696, "header": "tr|A0AAA9S9R3-1|A0AAA9S9R3_BOVIN Isoform 1 of Terminal nucleotidyltransferase 4B OS=Bos taurus OX=9913 GN=TENT4B PE=3 SV=2 CANONICAL=A0AAA9S9R3-1" }, "locus": { "chromosome": "18", "start_pos": 18640248, "end_pos": 18572250, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109614.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109614.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078885.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078885.2" } ] } }, { "isoform_ac": "F1MNP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3/entry#F1MNP2-1", "sequence": { "sequence": "MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHHCHSSGGASGGGGGGGSSTATGGSGSSTGSPSGAAPAPAPAGMYRSGERLLGGHAQPAEQRDFLPLETTNNNNNHHQPAAWARRAAAGPSASPSPSASPSPHSSTAVPAAEPADPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAPGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESISKHSSNSSSGPVSSSSATQSSSSDVHGSTRLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKRKHKRDAPLSDLCR", "length": 657, "header": "tr|F1MNP2-1|A0AAA9S9R3_BOVIN Computationally mapped isoform of Terminal nucleotidyltransferase 4B OS=Bos taurus OX=9913 GN=TENT4B PE=3 SV=4 CANONICAL=A0AAA9S9R3-1" }, "locus": { "chromosome": "18", "start_pos": 18640248, "end_pos": 18572983, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010440.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010440.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010440.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010440.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PH78-1", "protein_name": "Terminal nucleotidyltransferase 4B", "gene_name": "PAPD5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDPRIAWFQPEQLGPSNRLWMQIWETTQGVRNLYFQQQQQQEQQQQQSAPAGAGPASPPGMYRAPRADPQPDFLPLESANNQHNRGHRQASPPPGAAAWARPARGVPPAAAAAAAAAASNKRKRDNKASTFGLNYSLLLGPPGQGRAPALGDGPAARAQAGLAEPLYTGTPWKKRNYSQGVVGLHEEIIDFYKYMSPRHEEERMRMEVVNRIENVIKELWPNADVQIFGSFKTGLYLPTSDIDLVVFGKWETLPLWTLEEALRKHNVADENSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVKAAQLIKDFIKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACTPNANYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKSMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTQEVATYRDWISKQWGMQSRTESSCNGNGVTLIVDNQQLDKCNNNLAEENEALGKPRNKTSETLSKHSSNSSSGPLSSSSSTLSSSSDVDSDGTPCKTSKQLSCRQPTTNRVGSQEVSLESSQSSGKTQNSQTGNTSSNTNKSQHGSARLFRSSNKGFQGPANSSHGTSVTNKQHQGSKSHHQYFHGKKRKHKRDAALSDLCR", "length": 684 }, "evidence": [ { "id": "A0AAA9S9R3", "url": "https://omabrowser.org/oma/group/A0AAA9S9R3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LJG4-1", "protein_name": "Terminal nucleotidyltransferase 4B", "gene_name": "Tent4b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHHCHSSGASSASGGSGSGPGSPGGTAPAPAGMFRSGERPLGGLAVPAEQRDFLPLETTNNNNNHHQPAAWARRAAAGPSASPVPSAPSSPRPAAPLPASESADPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAAGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVSRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKCYPNNETESILGRIIRVTDEVTTYRDWISKQWGLQNRPEPSCNGNGVTLIVETQQLDKCNNNLSEENEAPGKCRSKASESLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQVLCRPPTVSRVGSQDVSLEVSQAVGKMQSTQTTNTANSTNKSQHGSARLFRSSSKGFQGTAQTSHGALMTSKQHPGKSNTQCYHGKKRRHKRDAPLSELCR", "length": 700 }, "evidence": [ { "id": "A0AAA9S9R3", "url": "https://omabrowser.org/oma/group/A0AAA9S9R3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q68ED3-1", "protein_name": "Terminal nucleotidyltransferase 4B", "gene_name": "Tent4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFRSGERPLGGLAVPAEQRDFLPLETTNNNNNHHQPAAWARRASAGPSASPVPSAPSSPRPAAALPASESTDPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAAGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVSRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEEKEALGKCRSNASEPLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPPTVTRVGSQDVSLEVSQAVGKMQSTQTTNTPNNANKSQHGSARLFRSSSKGFQGTAQTSHGALMTSKQHQGKSNTQYYHGKKRRHKRDAPLSELCR", "length": 633 }, "evidence": [ { "id": "A0AAA9S9R3", "url": "https://omabrowser.org/oma/group/A0AAA9S9R3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NDF8-1", "protein_name": "Terminal nucleotidyltransferase 4B", "gene_name": "TENT4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYRSGERLLGSHALPAEQRDFLPLETTNNNNNHHQPGAWARRAGSSASSPPSASSSPHPSAAVPAADPADSASGSSNKRKRDNKASGGRAAGGGRADGGGVVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLKNRPEPSCNGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPSTGNRVGSQDVSLESSQAVGKMQSTQTTNTSNSTNKSQHGSARLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKRKHKRDAPLSDLCR", "length": 572 }, "evidence": [ { "id": "A0AAA9S9R3", "url": "https://omabrowser.org/oma/group/A0AAA9S9R3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "poly(A) RNA polymerase activity", "id": "GO:1990817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "guanylyltransferase activity", "id": "GO:0070568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070568", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "TRAMP complex", "id": "GO:0031499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031499", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "RNA 3'-end processing", "id": "GO:0031123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "positive regulation of 3'-UTR-mediated mRNA stabilization", "id": "GO:1905870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905870", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "negative regulation of nuclear-transcribed mRNA poly(A) tail shortening", "id": "GO:0060212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" }, { "name": "polyadenylation-dependent ncRNA catabolic process", "id": "GO:0043634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 482, "end_pos": 484, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 564, "end_pos": 566, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 635, "end_pos": 637, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11332", "name": "", "equation": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RXW0-1", "G3N0D4-1", "G5E6N3-1", "P25500-1", "Q2HJ44-1", "Q1JPD6-1", "A0A3Q1MNQ1-1", "Q29RH2-1", "A0AAA9S9R3-1", "A0A3Q1MRX7-1", "A0ABI0NNI6-1" ], "evidence": [ { "id": "11332", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11332" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MNQ1", "gene_name": "TUT1", "activity": [ { "ec_number": "2.7.7.52", "activity": "RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] }, { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] }, { "ec_number": "2.7.7.52", "activity": "", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] } ] }, { "uniprot_ac": "A0A3Q1MRX7", "gene_name": "TENT4A", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0A3Q1MRX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRX7" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "A0A3Q1MRX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRX7" } ] } ] }, { "uniprot_ac": "A0AAA9RXW0", "gene_name": "TENT5A", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0AAA9RXW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXW0" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "A0AAA9RXW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXW0" } ] } ] }, { "uniprot_ac": "A0AAA9S9R3", "gene_name": "TENT4B", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" } ] } ] }, { "uniprot_ac": "A0ABI0NNI6", "gene_name": "PAPOLB", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0ABI0NNI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNI6" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "A0ABI0NNI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNI6" } ] } ] }, { "uniprot_ac": "G3N0D4", "gene_name": "TENT5D", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "G3N0D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0D4" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "G3N0D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0D4" } ] } ] }, { "uniprot_ac": "G5E6N3", "gene_name": "TENT5C", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "G5E6N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E6N3" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "G5E6N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E6N3" } ] } ] }, { "uniprot_ac": "P25500", "gene_name": "PAPOLA", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "P25500", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25500" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "P25500", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25500" } ] } ] }, { "uniprot_ac": "Q1JPD6", "gene_name": "TUT1", "activity": [ { "ec_number": "2.7.7.52", "activity": "RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate.", "evidence": [ { "id": "Q1JPD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPD6" } ] }, { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "Q1JPD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPD6" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "Q1JPD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPD6" } ] } ] }, { "uniprot_ac": "Q29RH2", "gene_name": "TENT5B", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "Q29RH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH2" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "Q29RH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH2" } ] } ] }, { "uniprot_ac": "Q2HJ44", "gene_name": "TENT2", "activity": [ { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "Q2HJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ44" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "Q2HJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ44" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" }, { "id": "PF03828", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03828" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PAP-associated", "eco_id": "ECO_0000259", "start_pos": 385, "end_pos": 445, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R3" }, { "id": "PF22600", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22600" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Poly(A) RNA polymerase mitochondrial-like central palm", "eco_id": "ECO_0000259", "start_pos": 197, "end_pos": 326, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.19", "ec_name": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "2.7.7.19", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19" }, { "id": "2.7.7.19", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.19" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 482, "end_pos": 484 }, { "start_pos": 539, "end_pos": 541 }, { "start_pos": 564, "end_pos": 566 }, { "start_pos": 632, "end_pos": 634 }, { "start_pos": 635, "end_pos": 637 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8M6-1", "uniprot_ac": "A0AAA9S8M6", "uniprot_id": "A0AAA9S8M6_BOVIN", "mass": { "chemical_mass": 36029.0, "monoisotopic_mass": 36029.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD45", "type": "recommended", "evidence": [ { "id": "A0AAA9S8M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 45", "type": "synonym", "evidence": [ { "id": "A0AAA9S8M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6", "locus": { "chromosome": "16", "start_pos": 55030423, "end_pos": 55095415, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044117", "url": "https://www.ensembl.org/id/ENSBTAG00000044117" } ] } } ], "crossref": [ { "id": "A0AAA9S8M6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044117", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044117", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100336740", "url": "https://www.ncbi.nlm.nih.gov/gene/100336740", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ATPRKFW", "url": "https://omabrowser.org/oma/group/ATPRKFW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NH70", "url": "https://www.orthodb.org/?gene=A0A3Q1NH70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198:SF165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198:SF165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24201:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24201:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NH70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NH70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NH70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NH70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMF0", "url": "https://www.uniprot.org/uniprotkb/F1MMF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMF0-1", "url": "https://www.uniprot.org/uniprotkb/F1MMF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDYSMPGFPVLHYLLELLKLMCVELMMPFNHLILCCPFSSCLQSFPASRSFPVFLELMESEIPPESESSEKLIFSSPQEEEEEEDDSEEEEESKEAEETATINPLLPPALTGDVEGLQKIFEDPENSHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRKERARDVAARYSQTECVEFLDWAEARLALKKYIAKVSATVTDTEKGPGKLYKEDKNILLSACRVKNEWLETHLEASINELFEQKQQLEDIVTPIFTKMATPRQVKSAKSV", "length": 318, "header": "tr|A0AAA9S8M6-1|A0AAA9S8M6_BOVIN Isoform 1 of Ankyrin repeat domain 45 OS=Bos taurus OX=9913 GN=ANKRD45 PE=4 SV=1 CANONICAL=A0AAA9S8M6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NH70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6/entry#A0A3Q1NH70-1", "sequence": { "sequence": "MVTTQSRGLGNEYIMRNAGLEEAQAGIKVFLELMESEIPPESESSEKLIFSSPQEEEEEEDDSEEEEESKEAEETATINPLLPPALTGDVEGLQKIFEDPENSHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRKERARDVAARYSQTECVEFLDWAEARLALKKYIAKVSATVTDTEKGPGKLYKEDKNILLSACRVKNEWLETHLEASINELFEQKQQLEDIVTPIFTKMATPRQVKSAKSV", "length": 294, "header": "tr|A0A3Q1NH70-1|A0AAA9S8M6_BOVIN Computationally mapped isoform of Ankyrin repeat domain 45 OS=Bos taurus OX=9913 GN=ANKRD45 PE=4 SV=2 CANONICAL=A0AAA9S8M6-1" }, "locus": { "chromosome": "16", "start_pos": 55095350, "end_pos": 55051818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070378.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070378.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071267.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071267.2" } ] } }, { "isoform_ac": "A0AAA9S8M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6/entry#A0AAA9S8M6-1", "sequence": { "sequence": "MDYSMPGFPVLHYLLELLKLMCVELMMPFNHLILCCPFSSCLQSFPASRSFPVFLELMESEIPPESESSEKLIFSSPQEEEEEEDDSEEEEESKEAEETATINPLLPPALTGDVEGLQKIFEDPENSHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRKERARDVAARYSQTECVEFLDWAEARLALKKYIAKVSATVTDTEKGPGKLYKEDKNILLSACRVKNEWLETHLEASINELFEQKQQLEDIVTPIFTKMATPRQVKSAKSV", "length": 318, "header": "tr|A0AAA9S8M6-1|A0AAA9S8M6_BOVIN Isoform 1 of Ankyrin repeat domain 45 OS=Bos taurus OX=9913 GN=ANKRD45 PE=4 SV=1 CANONICAL=A0AAA9S8M6-1" }, "locus": { "chromosome": "16", "start_pos": 55091725, "end_pos": 55051818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105414.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105414.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079704.1" } ] } }, { "isoform_ac": "A0AAA9TQL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6/entry#A0AAA9TQL9-1", "sequence": { "sequence": "MESEIPPESESSEKLIFSSPQEEEEEEDDSEEEEESKEAEETATINPLLPPALTGDVEGLQKIFEDPENSHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRKERARDVAARYSQTECVEFLDWAEARLALKKYIAKVSATVTDTEKGPGKLYKEDKNILLSACRVKNEWLETHLEASINELFEQKQQLEDIVTPIFTKMATPHAPSRLPSSKNIKFFTLLLFFTFNYIYGCFGCGLLYTQECVLAGLLNRIN", "length": 302, "header": "tr|A0AAA9TQL9-1|A0AAA9TQL9_BOVIN Computationally mapped isoform of Ankyrin repeat domain 45 OS=Bos taurus OX=9913 GN=ANKRD45 PE=4 SV=1 CANONICAL=A0AAA9S8M6-1" }, "locus": { "chromosome": "16", "start_pos": 55090901, "end_pos": 55030483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130737.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130737.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100882.1" } ] } }, { "isoform_ac": "A0AAA9TTX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6/entry#A0AAA9TTX9-1", "sequence": { "sequence": "MESEIPPESESSEKLIFSSPQEEEEEEDDSEEEEESKEAEETATINPLLPPALTGDVEGLQKIFEDPENSHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRKERARDVAARYSQTECVEFLDWAEARLALKKYIAKVSATVTDTEKGPGKLYKEDKNILLSACRVKNEWLETHLEASINELFEQKQQLEDIVTPIFTKMATPRYSHSSAPPSLTNRIQL", "length": 269, "header": "tr|A0AAA9TTX9-1|A0AAA9TTX9_BOVIN Computationally mapped isoform of Ankyrin repeat domain 45 OS=Bos taurus OX=9913 GN=ANKRD45 PE=4 SV=1 CANONICAL=A0AAA9S8M6-1" }, "locus": { "chromosome": "16", "start_pos": 55090901, "end_pos": 55044050, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135400.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135400.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102069.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102069.1" } ] } }, { "isoform_ac": "F1MMF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6/entry#F1MMF0-1", "sequence": { "sequence": "MESEIPPESESSEKLIFSSPQEEEEEEDDSEEEEESKEAEETATINPLLPPALTGDVEGLQKIFEDPENSHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRKERARDVAARYSQTECVEFLDWAEARLALKKYIAKVSATVTDTEKGPGKLYKEDKNILLSACRVKNEWLETHLEASINELFEQKQQLEDIVTPIFTKMATPR", "length": 253, "header": "tr|F1MMF0-1|A0AAA9S8M6_BOVIN Computationally mapped isoform of Ankyrin repeat domain 45 OS=Bos taurus OX=9913 GN=ANKRD45 PE=4 SV=3 CANONICAL=A0AAA9S8M6-1" }, "locus": { "chromosome": "16", "start_pos": 55090901, "end_pos": 55043539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061192.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061192.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053489.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053489.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G3U6-1", "protein_name": "Cyclic nucleotide-binding domain-containing protein", "gene_name": "Slc9c2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNNSFSFWVARNDNKPDLLCGRPADYFVVQKHFTILICATIVLGGFSRMVLKNSEVFVMIILSVSGFVTGRLAYNFIEVHQIVYPLLKTPSFSLYCYFLPLIVFVAALDVDFYIVKNVFWQVLLTGLISFGTAFATISYVVLKFHEDKWDLQCCLLFSITLCIIDPLHSVNSLKMIGISKMYTDIIRGESLIICSFTCIFFGIFRGHTTNVSMFRELHVIIGLSFDIFGSAVCGYWCTRVIQIILTDLFSNTLTNVVLCFSLVYMTFYLVEYFGMSGIVALVTVGLNLDSLSFKPRMEFIITKFLIMCSSVYEHLIYAFFGIVIGCGEIKYFRFHSLVFTVTLFVTVNFVRLLTIILVSPILMHSSYEYDWRWGVVITWSGIRGVFSLLLAPDIYNFSEYKLAAPHMCIFYIQALSILTTGINSHMMLRSAKTLGLCALSLPRQMAVRNATEHIQEIIRNTITLFKTEKILTNVNWNVVEEKAKIEYNPILKQARTVPLAHISHGPREESPTDEVLIEEARLHVAIIQMSSFEKQCNDGILGVEAARILIGATKSYCPIHGKFMSISDVSTYVRARSWLIKFKNMLTYLEYHKERVLFTVPGNNKLLIFVYRIIISEEFEYATHVVTVMYIFPMIIHLWPIARELNVSALISINYYYMFLYTLESALKILILKRKYFLQNWNTLDFFIIVLGIVDILCMYFVKLRPDSLVLIQFTVVIGYLRVIRFLPIFKIIIPVLINMADVQIKKSLSLMYSITKGYVKSQEDAKLLVRQISGRESIYQKLYDILERNKREAIRELGLIEHEGRDVVIALKTKQTIRNVIAKALKNLTFLWSRGIIDKHEGIEMNKVLLTKIKALNNFPMAIPPPTPDKYLPNIVWMENKDVLIEFFKERTKLTYFDYGDIICREGEMPQGIFLIISGMASLHSSSATFGIDPSPRTTDRQSKTMYTEYCTSGDVLGELSCLLKREIEYTAICETTLQAFFISLEDLYEGFDVFWPSLEYKMWLKLALSIANQYFESSIAGEDLKFQKCVMFNHAYVETLSSYNEMTLNHVNMKLIILVYGNVINSKTEETHVAPCIIPKSCEQIQGISDVSKLLVIPTSEPVKKDATSHDVVSTGLRTTKKDYSWKRKDEFEGGHLFRKTY", "length": 1145 }, "evidence": [ { "id": "A0AAA9S8M6", "url": "https://omabrowser.org/oma/group/A0AAA9S8M6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B0S794-1", "protein_name": "Ankyrin repeat domain-containing protein 45", "gene_name": "ankrd45", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRSAEEKTVLLCALDDDLEGLKGILERTFTDDAAQSENILWEKDEVGRNALFAACMMGRSAIVRELVQNGAADVNELTARGYSPLHCSAMWGQLDTLKTLVELNADFQAINFRGEKAVDVARRYDKLDCAEYLAWAEAKQNLQAFIQEVRAIVADQEKVQGKLNKEDKNICINTCSAKSDWINNTRTATAQDFIEQKKLLEDVLAPVLLKLNAQPEASMKTRKN", "length": 224 }, "evidence": [ { "id": "A0AAA9S8M6", "url": "https://omabrowser.org/oma/group/A0AAA9S8M6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5TZF3-2", "protein_name": "Ankyrin repeat domain-containing protein 45", "gene_name": "ANKRD45", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESEGPPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKMTTPCQVKSAKSVTSHDQKRSQDDTSN", "length": 266 }, "evidence": [ { "id": "A0AAA9S8M6", "url": "https://omabrowser.org/oma/group/A0AAA9S8M6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q810N6-1", "protein_name": "Ankyrin repeat domain-containing protein 45", "gene_name": "Ankrd45", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPEETLESESSEKSLFSSQQEYEESQEAEETGAENPLLQPTLTGDVEGLQKIFEDPEHPHHEHAVQLLLEEDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEIFEQKQQLEDIVSPILAKMSTPRHFAAS", "length": 248 }, "evidence": [ { "id": "A0AAA9S8M6", "url": "https://omabrowser.org/oma/group/A0AAA9S8M6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8M6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6S6-1", "uniprot_ac": "A0AAA9S6S6", "uniprot_id": "A0AAA9S6S6_BOVIN", "mass": { "chemical_mass": 47220.0, "monoisotopic_mass": 47220.0 }, "refseq": {}, "gene_names": [ { "name": "RNF128", "type": "recommended", "evidence": [ { "id": "A0AAA9S6S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ] } ], "protein_names": [ { "name": "Ring finger protein 128", "type": "synonym", "evidence": [ { "id": "A0AAA9S6S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF128", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6", "locus": { "chromosome": "X", "start_pos": 55325969, "end_pos": 55225566, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022920", "url": "https://www.ensembl.org/id/ENSBTAG00000022920" } ] } } ], "crossref": [ { "id": "A0AAA9S6S6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6S6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022920", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022920", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02122", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02122", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16802", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16802", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535869", "url": "https://www.ncbi.nlm.nih.gov/gene/535869", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NKSRFFW", "url": "https://omabrowser.org/oma/group/NKSRFFW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR16200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46539", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46539", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46539:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46539:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689896", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RTR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCR4", "url": "https://www.uniprot.org/uniprotkb/F1MCR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCR4-1", "url": "https://www.uniprot.org/uniprotkb/F1MCR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQLPGAGVFCRGGCGFSRLLAWCFLLVLSPQTPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVPGDWGSSVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHVFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNETSSNASPHEEDNRSETASSGYASVQGADEPPLEEHAHSAIQLWPLVIIIMLRWRQQPTPVFLPGESNGWRSLAGYSPWDHKSRT", "length": 432, "header": "tr|A0AAA9S6S6-1|A0AAA9S6S6_BOVIN Isoform 1 of Ring finger protein 128 OS=Bos taurus OX=9913 GN=RNF128 PE=4 SV=1 CANONICAL=A0AAA9S6S6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6/entry#A0AAA9RTR2-1", "sequence": { "sequence": "MGQLPGAGVFCRGGCGFSRLLAWCFLLVLSPQTPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVPGDWGSSVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHVFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNETSSNASPHEEDNRSETASSGYASVQGADEPPLEEHAHSASEHQAEGPQVPHK", "length": 400, "header": "tr|A0AAA9RTR2-1|A0AAA9S6S6_BOVIN Computationally mapped isoform of Ring finger protein 128 OS=Bos taurus OX=9913 GN=RNF128 PE=4 SV=2 CANONICAL=A0AAA9S6S6-1" }, "locus": { "chromosome": "X", "start_pos": 55315041, "end_pos": 55261166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111409.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111409.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075360.2", "url": "https://www.ensembl.org/id/ENSBTAP00000075360.2" } ] } }, { "isoform_ac": "A0AAA9S6S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6/entry#A0AAA9S6S6-1", "sequence": { "sequence": "MGQLPGAGVFCRGGCGFSRLLAWCFLLVLSPQTPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVPGDWGSSVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHVFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNETSSNASPHEEDNRSETASSGYASVQGADEPPLEEHAHSAIQLWPLVIIIMLRWRQQPTPVFLPGESNGWRSLAGYSPWDHKSRT", "length": 432, "header": "tr|A0AAA9S6S6-1|A0AAA9S6S6_BOVIN Isoform 1 of Ring finger protein 128 OS=Bos taurus OX=9913 GN=RNF128 PE=4 SV=1 CANONICAL=A0AAA9S6S6-1" }, "locus": { "chromosome": "X", "start_pos": 55318714, "end_pos": 55261166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111039.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111039.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081697.1" } ] } }, { "isoform_ac": "A0AAA9SI32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6/entry#A0AAA9SI32-1", "sequence": { "sequence": "MNQETKSSFQLLVIFTFLFKITASFSINAYVTVTYYNETSNYTSAETCECGVYGLASPVANAMGVVGIPKNNNYQACDYNTEFTYTKKPWIALIERGNCTFSEKIQTAGRRNADAVVIYNLPETGNQTIQMANFGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHVFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNETSSNASPHEEDNRSETASSGYASVQGADEPPLEEHAHSANENLQLVNHEANSMAVDVVPHVDNPTFEEDESPDQETTVREIKS", "length": 401, "header": "tr|A0AAA9SI32-1|A0AAA9SI32_BOVIN Computationally mapped isoform of Ring finger protein 128 OS=Bos taurus OX=9913 GN=RNF128 PE=4 SV=1 CANONICAL=A0AAA9S6S6-1" }, "locus": { "chromosome": "X", "start_pos": 55324674, "end_pos": 55225765, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113463.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113463.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083403.1" } ] } }, { "isoform_ac": "F1MCR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6/entry#F1MCR4-1", "sequence": { "sequence": "MGQLPGAGVFCRGGCGFSRLLAWCFLLVLSPQTPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVPGDWGSSVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHVFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNETSSNASPHEEDNRSETASSGYASVQGADEPPLEEHAHSAIQLWPLVIIIMLR", "length": 400, "header": "tr|F1MCR4-1|F1MCR4_BOVIN Computationally mapped isoform of Ring finger protein 128 OS=Bos taurus OX=9913 GN=RNF128 PE=4 SV=3 CANONICAL=A0AAA9S6S6-1" }, "locus": { "chromosome": "X", "start_pos": 55317975, "end_pos": 55261166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031148.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031148.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031108.5", "url": "https://www.ensembl.org/id/ENSBTAP00000031108.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-BTA-5689896", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689896", "resource": "Reactome", "description": "Ovarian tumor domain proteases" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QK34-1", "protein_name": "E3 ubiquitin-protein ligase RNF128 isoform X2", "gene_name": "Rnf128", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGPPPGTRVTCRGACGAARLLAWCFLLALSPHAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVSGVLVPPDGPGALNACNPHTNFTVPTMQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNDASNTASPHEEDNRSETASSGYASVQGADEPPLEEHVQSANENLQLVNHEASSVAVDVVPHVDNPTFEEDESPNEETAVREIKS", "length": 423 }, "evidence": [ { "id": "A0AAA9S6S6", "url": "https://omabrowser.org/oma/group/A0AAA9S6S6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YGH2-1", "protein_name": "Ring finger protein 128", "gene_name": "RNF128", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASGAAGLLAAVAALLCVVPEPGVGAAAAVWTAWLNVSWEDGAGGNRSGWEAGESGLYGQDSPLQAAAGLLVLPDGRDAFNACSALTNFSAAPPGGGPGWVALIQRGGGCSFADKIRLAAERGAAAAVIYNYRGTGNDVLPMSHAGAGSIVAIMIGNLKGMEILRRIESGLKVTMVIEVGKKHGPWMNHYSIFFVSVSFFIVTAATVGYFIFYSARRFRITRAQSRKQRQLKAEAKKAIGQLQLRTLKQGDKETGPDGDSCAVCIELYKPNEVVRILTCNHLFHKNCIDPWLLEHRTCPMCKCDILKVLGVEVDAEDGAESVQATVSSGTSNITSINEVDSHSETASSGYASVQGADESVLEEHAPSENDNTHLVNNESQTSAVTVLPPLDNPTFEADETQVSEVRS", "length": 407 }, "evidence": [ { "id": "A0AAA9S6S6", "url": "https://omabrowser.org/oma/group/A0AAA9S6S6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LEX1-1", "protein_name": "Ring finger protein 128", "gene_name": "RNF128", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNQENKSSRFRLLLVFTVLFKITAPFSMNAYVTVTYYNETSNDTSTETCECGVYGLASPVADAVGVVGIPKNNNYQACDYNTEFTNTKKPWIALIERGNCTFSEKIQTAGRRNADAVVIYNVPETGNQTIQMANFGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNETSNSASPHEEDNRSETASSGYASVQGADEPPLEEHVQSANENLQLVNHEASSMAVDVVPHVDNPTFEEDETPGQETAVREIKS", "length": 402 }, "evidence": [ { "id": "A0AAA9S6S6", "url": "https://omabrowser.org/oma/group/A0AAA9S6S6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8TEB7-1", "protein_name": "E3 ubiquitin-protein ligase RNF128", "gene_name": "RNF128", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPPPGAGVSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVREIKS", "length": 428 }, "evidence": [ { "id": "A0AAA9S6S6", "url": "https://omabrowser.org/oma/group/A0AAA9S6S6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D304-1", "protein_name": "E3 ubiquitin-protein ligase RNF128", "gene_name": "Rnf128", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPPPGIGVYCRGGCGAARLLAWCFLLALSPHAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVSGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEASNTASPHEEDSRSETASSGYASVQGADEPPLEEHAQSANENLQLVNHEANSVAVDVVPHVDNPTFEEDETPDQEAAVREIKS", "length": 428 }, "evidence": [ { "id": "A0AAA9S6S6", "url": "https://omabrowser.org/oma/group/A0AAA9S6S6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S6" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 280, "end_pos": 321, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7P6-1", "uniprot_ac": "A0AAA9S7P6", "uniprot_id": "A0AAA9S7P6_BOVIN", "mass": { "chemical_mass": 25624.0, "monoisotopic_mass": 25624.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Glutathione peroxidase", "type": "recommended", "evidence": [ { "id": "A0AAA9S7P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7P6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16833", "url": "https://www.rhea-db.org/rhea/16833", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVHKVASIHDKDSQKLLRDYHLLYHHITVVIFVIFQVDCYKGVTGTIYEYGALTLNGEEYIQFKQYVGKHVLATHAVHPLLTELNALQEELKPFGVVVLGFPCNQFGKQEPAKNSEILMGLKYVRPGGGFVPNFQLFEKGDVNGEKEQKVFTFLKNACPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMRWYHRASVSTVKSDMLEYLKQFKSE", "length": 224, "header": "tr|A0AAA9S7P6-1|A0AAA9S7P6_BOVIN Isoform 1 of Glutathione peroxidase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S7P6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6/entry#A0AAA9S7P6-1", "sequence": { "sequence": "MPVHKVASIHDKDSQKLLRDYHLLYHHITVVIFVIFQVDCYKGVTGTIYEYGALTLNGEEYIQFKQYVGKHVLATHAVHPLLTELNALQEELKPFGVVVLGFPCNQFGKQEPAKNSEILMGLKYVRPGGGFVPNFQLFEKGDVNGEKEQKVFTFLKNACPPTSDLLGSSSQLFWEPMKVHDIRWNFEKFLVGPDGVPVMRWYHRASVSTVKSDMLEYLKQFKSE", "length": 224, "header": "tr|A0AAA9S7P6-1|A0AAA9S7P6_BOVIN Isoform 1 of Glutathione peroxidase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S7P6-1" }, "locus": { "chromosome": "23", "start_pos": 30276326, "end_pos": 30271050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129997.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129997.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079955.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079955.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glutathione peroxidase activity", "id": "GO:0004602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16833", "name": "", "equation": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1", "P37141-1", "F1N076-1", "A0A3Q1M314-1" ], "evidence": [ { "id": "16833", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16833" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M314", "gene_name": "HEPH", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] } ] }, { "uniprot_ac": "F1N076", "gene_name": "CP", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] } ] }, { "uniprot_ac": "P00435", "gene_name": "GPX1", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] } ] }, { "uniprot_ac": "P37141", "gene_name": "GPX3", "activity": [ { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P37141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P37141" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P37141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P37141" } ] } ] }, { "uniprot_ac": "Q9N2J2", "gene_name": "GPX4", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] }, { "ec_number": "1.11.1.12", "activity": "", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9K9-1", "uniprot_ac": "A0AAA9S9K9", "uniprot_id": "A0AAA9S9K9_BOVIN", "mass": { "chemical_mass": 99024.0, "monoisotopic_mass": 99024.0 }, "refseq": {}, "gene_names": [ { "name": "BBS9", "type": "recommended", "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ] } ], "protein_names": [ { "name": "Bardet-Biedl syndrome 9", "type": "synonym", "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BBS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9", "locus": { "chromosome": "4", "start_pos": 63246705, "end_pos": 63729944, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006528", "url": "https://www.ensembl.org/id/ENSBTAG00000006528" } ] } } ], "crossref": [ { "id": "A0AAA9S9K9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9K9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006528", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006528", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535387", "url": "https://www.ncbi.nlm.nih.gov/gene/535387", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6VBU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VBU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VBV", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VBV&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VNW", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VNW&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VOA", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VOA&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "E1BHJ5", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BHJ5*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR026511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BHJ5", "url": "https://www.orthodb.org/?gene=E1BHJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20991", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20991", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20991:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20991:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006vbu", "url": "https://www.rcsb.org/structure/pdb_00006vbu", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006vbv", "url": "https://www.rcsb.org/structure/pdb_00006vbv", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006vnw", "url": "https://www.rcsb.org/structure/pdb_00006vnw", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006voa", "url": "https://www.rcsb.org/structure/pdb_00006voa", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VBU", "url": "https://www.rcsb.org/structure/6VBU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VBV", "url": "https://www.rcsb.org/structure/6VBV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VNW", "url": "https://www.rcsb.org/structure/6VNW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VOA", "url": "https://www.rcsb.org/structure/6VOA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF14727", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14727", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14728", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14728", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23338", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23338", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9K9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHJ5", "url": "https://www.uniprot.org/uniprotkb/E1BHJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHJ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BHJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQDKIIVGSFMGYLRIFNPHPVKTGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPDCVKKRPI", "length": 885, "header": "tr|A0AAA9S9K9-1|A0AAA9S9K9_BOVIN Isoform 1 of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RV49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9RV49-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQDKIIVGSFMGYLRIFNPHPVKTGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPEVSPLQGVTE", "length": 852, "header": "tr|A0AAA9RV49-1|A0AAA9S9K9_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63255758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104947.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104947.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074950.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074950.1" } ] } }, { "isoform_ac": "A0AAA9S9K9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9S9K9-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQDKIIVGSFMGYLRIFNPHPVKTGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPDCVKKRPI", "length": 885, "header": "tr|A0AAA9S9K9-1|A0AAA9S9K9_BOVIN Isoform 1 of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63246748, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102598.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102598.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078829.1" } ] } }, { "isoform_ac": "A0AAA9SEP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9SEP0-1", "sequence": { "sequence": "MSALPQGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPEVSPLQGVTE", "length": 805, "header": "tr|A0AAA9SEP0-1|A0AAA9SEP0_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63695632, "end_pos": 63255758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115546.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115546.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080872.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080872.1" } ] } }, { "isoform_ac": "A0AAA9SF60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9SF60-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGTSP", "length": 801, "header": "tr|A0AAA9SF60-1|A0AAA9SF60_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63296423, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082247.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082247.1" } ] } }, { "isoform_ac": "A0AAA9SL93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9SL93-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPVSPLQGVTE", "length": 864, "header": "tr|A0AAA9SL93-1|A0AAA9SL93_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63255758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096682.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096682.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083410.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083410.1" } ] } }, { "isoform_ac": "A0AAA9SSK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9SSK5-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQDKIIVGSFMGYLRIFNPHPVKTGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPEVSPLQGVTE", "length": 847, "header": "tr|A0AAA9SSK5-1|A0AAA9SSK5_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63255758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117974.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117974.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088313.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088313.1" } ] } }, { "isoform_ac": "A0AAA9TH91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#A0AAA9TH91-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQDKIIVGSFMGYLRIFNPHPVKTGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTERNPDGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPEVSPLQGVTE", "length": 869, "header": "tr|A0AAA9TH91-1|A0AAA9TH91_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=1 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63255758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110733.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110733.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095589.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095589.1" } ] } }, { "isoform_ac": "E1BHJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9/entry#E1BHJ5-1", "sequence": { "sequence": "MSLFKARDWWSTVLGDKEEFDQGCLCLADVDNTGNGQDKIIVGSFMGYLRIFNPHPVKTGDGAQAEDLLLEVHLRDPILQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQYQIKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSVDGMLMVFEQESYAFGRFLPGSLLPGPLAYSSRTDSFITVSSCHQVESYKYQVLAFATDADKRQETEQQKHGSGKRLVVDWTLNIGEQAIDICIVSFIQSASSVFVLGERNFFCLKDNGQIQFMKKLDYSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHVPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDMELKELQKVIKNVNKSQDVWPLTEREDDLKVSAMVSPNFDSVSQATDVEVGADLVPSVTVKVTLKNRVALQKIKLSIYVQPPLVLTGDQFTFEFMAPEMTRTVGFSVYLKGSYSPPELEGNAVVSYSRPTGIPRVSQCKFRLPLKLVCLPGQPSKTASHKLTIDTNKSPVSLLSLFPGFAKQSEDDQVNVMGFRFLGGSQVTLLASKTSQRYRIQSEQFEDLWLITNELIIRLQEYFEKQGIKDFTCSFSGSVPLEEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLTRFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQDNLFQSFTRLKSATHLVILLIGLWQKLSADQIAILEAAFLPLQQDTQELGWEETVDAALSHLLKTCLSKSSKEQALNLNSQLGIPKDTSQLKKHITLFCDRLAKGGRLCLSTDAAAPQTMVMPGGCATIPESDLEGRSIDQDSSELFTNHKHLMVETPVPEVSPLQGVTE", "length": 882, "header": "tr|E1BHJ5-1|A0AAA9S9K9_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 9 OS=Bos taurus OX=9913 GN=BBS9 PE=4 SV=3 CANONICAL=A0AAA9S9K9-1" }, "locus": { "chromosome": "4", "start_pos": 63708251, "end_pos": 63255758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008587.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008587.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008587.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008587.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure and activation mechanism of the BBSome membrane protein trafficking complex.", "journal": "Elife", "date": "2020", "authors": "Singh SK, Gui M, Koh F, Yip MC, Brown A", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ5", "url": "https://www.uniprot.org/uniprotkb/E1BHJ5" } ], "reference": [ { "type": "PubMed", "id": "31939736", "url": "https://glygen.org/publication/PubMed/31939736" } ] }, { "title": "Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.", "journal": "Elife", "date": "2020", "authors": "Yang Shuang, Bahl Kriti, Chou Hui-Ting, Woodsmith Jonathan, Stelzl Ulrich, Walz Thomas, Nachury Maxence V", "evidence": [ { "database": "UniProtKB", "id": "E1BHJ5", "url": "https://www.uniprot.org/uniprotkb/E1BHJ5" } ], "reference": [ { "type": "PubMed", "id": "32510327", "url": "https://glygen.org/publication/PubMed/32510327" } ] } ], "pathway": [ { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "BBSome", "id": "GO:0034464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "pericentriolar material", "id": "GO:0000242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000242", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" }, { "id": "PF23339", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23339" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PTHB1 C-terminal helix bundle", "eco_id": "ECO_0000259", "start_pos": 744, "end_pos": 819, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" }, { "id": "PF14728", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14728" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PTHB1 GAE", "eco_id": "ECO_0000259", "start_pos": 437, "end_pos": 527, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" }, { "id": "PF14727", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14727" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PTHB1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 363, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" }, { "id": "PF23338", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23338" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PTHB1 hairpin", "eco_id": "ECO_0000259", "start_pos": 640, "end_pos": 742, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K9" }, { "id": "PF23337", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23337" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PTHB1 platform", "eco_id": "ECO_0000259", "start_pos": 530, "end_pos": 637, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 396, "end_pos": 398 }, { "start_pos": 553, "end_pos": 555 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9S7R9-1", "uniprot_ac": "A0AAA9S7R9", "uniprot_id": "A0AAA9S7R9_BOVIN", "mass": { "chemical_mass": 124914.0, "monoisotopic_mass": 124914.0 }, "refseq": { "ac": "XP_024843707", "name": "rho GTPase-activating protein 36 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843707" }, "gene_names": [ { "name": "ARHGAP36", "type": "recommended", "evidence": [ { "id": "A0AAA9S7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" } ] }, { "name": "ARHGAP36", "type": "synonym", "evidence": [ { "id": "XP_024843707", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843707" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 36", "type": "recommended", "evidence": [ { "id": "A0AAA9S7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9/entry#names_and_taxonomy" } ] }, { "name": "rho GTPase-activating protein 36 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024843707", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843707" } ] } ], "function": [ { "annotation": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RVY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVY8#function" }, { "database": "UniProtKB", "id": "ARBA00055252", "url": "https://www.uniprot.org/uniprotkb/ARBA00055252#function" }, { "database": "UniProtKB", "id": "A0AAF6Z927", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z927#function" }, { "database": "UniProtKB", "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9", "locus": { "chromosome": "X", "start_pos": 15112740, "end_pos": 15081369, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021189", "url": "https://www.ensembl.org/id/ENSBTAG00000021189" } ] } } ], "crossref": [ { "id": "A0AAA9S7R9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7R9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514137", "url": "https://www.ncbi.nlm.nih.gov/gene/514137", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12635", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12635", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12635:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12635:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024843707", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843707", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RVY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z927", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z927", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z927-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z927-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGCIPFLKTARTRYPRIMPPLLLLSALIFLVNVLGGAPGHNPNRRAKMISIHSLSELERLKLQEAAYHELVARQFLSEFKPERALPTDRSNTFEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQVELRATMQMQEAAGPATSGRRRGNAVQRMFGRIRRIFSGRRDEPFLPREFTRRGRRGAVSADSLAELEGGALLLQTLQLSRISFPIGQRLLGSKRKMSLNPIAKQIPHVVEACCSFIEKHGLSTVGIFTLEYSEKRVRKLREEFDQGLDVVLDDSQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLQTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKVLHKVAENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGASAKRESRKTRLGIDHYVASVSVVRAMIDNWDVLFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSERIKMEEDALLSDPVETSAEARAAILGQSKPFDEGQFPAGGQTLAEGQAFAAGESLGEGQALPQGQVLVEVEPLEEDESSEDDMSVNEELVFEYLNQGLAFGELQGLEIPNDLEIQGPHLEGIPELDEEDDDDDDDDDNDDDNALNFDGLPLLEDILDADDEIPGFMEIADFDEIPYFNFVPDPGVVPDVQEVPNVGVNPNPGENPNHDLDEDFEDYQNPNLAEVPDPDVVPNIEEASDPDEIPDNEEAPDTDEIPDHANDSDNDEDPDFGEDPNPEDVLALDEIPNDEASNAEEVPDHQEAPEINGISDSDEDFDYDEVPGIHVVPSPEEASGGHVPSPEEAPGGHEIPNHEEAPEINGLSDSEEDPNLEEVPALDGVPNEEETSATEEIPEISGIAGSEEYSSPEEVPTLHVVTSPEDVFDADEIQSQEESSDESGVLNHEETSDVEEISGREEATDVHEIQDSEENHDLEGDSVLSMVPEPKDTQICNEIPVSQKDLGNTFEEDEVNVTAELEDVSILSTIPDPQPDLAVNLEEIMNEETVPVPNTVDSKEAQHPKTVWFRQEDADVTFLVDNTFFKNQSQPGQVMDYMSFLESLKNNACFRLSMKFCSSEEPAVPPGTARSHDDEEGAGNPLILEQDRPLLRVPREKEAKTGIGYFFP", "length": 1124, "header": "tr|A0AAA9S7R9-1|A0AAA9S7R9_BOVIN Isoform 1 of Rho GTPase-activating protein 36 OS=Bos taurus OX=9913 GN=ARHGAP36 PE=4 SV=1 CANONICAL=A0AAA9S7R9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9/entry#A0AAA9RVY8-1", "sequence": { "sequence": "MAWMLDCLFASAFEPRPRRVNVLGGAPGHNPNRRAKMISIHSLSELERLKLQEAAYHELVARQFLSEFKPERALPTDRSNTFEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQVELRATMQMQEAAGPATSGRRRGNAVQRMFGRIRRIFSGRRDEPFLPREFTRRGRRGAVSADSLAELEGGALLLQTLQLSRISFPIGQRLLGSKRKMSLNPIAKQIPHVVEACCSFIEKHGLSTVGIFTLEYSEKRVRKLREEFDQGLDVVLDDSQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLQTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKVLHKVAENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGASAKRESRKTRLGIDHYVASVSVVRAMIDNWDVLFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSERIKMEEDALLSDPVETSAEARAAILGQSKPFDEGSSEEPAVPPGTARSHDDEEGAGNPLILEQDRPLLRVPREKEAKTGIGYFFP", "length": 536, "header": "tr|A0AAA9RVY8-1|A0AAA9S7R9_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 36 OS=Bos taurus OX=9913 GN=ARHGAP36 PE=4 SV=1 CANONICAL=A0AAA9S7R9-1" }, "locus": { "chromosome": "X", "start_pos": 15111683, "end_pos": 15081369, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077560.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077560.1" } ] } }, { "isoform_ac": "A0AAA9S7R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9/entry#A0AAA9S7R9-1", "sequence": { "sequence": "MGGCIPFLKTARTRYPRIMPPLLLLSALIFLVNVLGGAPGHNPNRRAKMISIHSLSELERLKLQEAAYHELVARQFLSEFKPERALPTDRSNTFEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQVELRATMQMQEAAGPATSGRRRGNAVQRMFGRIRRIFSGRRDEPFLPREFTRRGRRGAVSADSLAELEGGALLLQTLQLSRISFPIGQRLLGSKRKMSLNPIAKQIPHVVEACCSFIEKHGLSTVGIFTLEYSEKRVRKLREEFDQGLDVVLDDSQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLQTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKVLHKVAENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGASAKRESRKTRLGIDHYVASVSVVRAMIDNWDVLFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSERIKMEEDALLSDPVETSAEARAAILGQSKPFDEGQFPAGGQTLAEGQAFAAGESLGEGQALPQGQVLVEVEPLEEDESSEDDMSVNEELVFEYLNQGLAFGELQGLEIPNDLEIQGPHLEGIPELDEEDDDDDDDDDNDDDNALNFDGLPLLEDILDADDEIPGFMEIADFDEIPYFNFVPDPGVVPDVQEVPNVGVNPNPGENPNHDLDEDFEDYQNPNLAEVPDPDVVPNIEEASDPDEIPDNEEAPDTDEIPDHANDSDNDEDPDFGEDPNPEDVLALDEIPNDEASNAEEVPDHQEAPEINGISDSDEDFDYDEVPGIHVVPSPEEASGGHVPSPEEAPGGHEIPNHEEAPEINGLSDSEEDPNLEEVPALDGVPNEEETSATEEIPEISGIAGSEEYSSPEEVPTLHVVTSPEDVFDADEIQSQEESSDESGVLNHEETSDVEEISGREEATDVHEIQDSEENHDLEGDSVLSMVPEPKDTQICNEIPVSQKDLGNTFEEDEVNVTAELEDVSILSTIPDPQPDLAVNLEEIMNEETVPVPNTVDSKEAQHPKTVWFRQEDADVTFLVDNTFFKNQSQPGQVMDYMSFLESLKNNACFRLSMKFCSSEEPAVPPGTARSHDDEEGAGNPLILEQDRPLLRVPREKEAKTGIGYFFP", "length": 1124, "header": "tr|A0AAA9S7R9-1|A0AAA9S7R9_BOVIN Isoform 1 of Rho GTPase-activating protein 36 OS=Bos taurus OX=9913 GN=ARHGAP36 PE=4 SV=1 CANONICAL=A0AAA9S7R9-1" }, "locus": { "chromosome": "X", "start_pos": 15111683, "end_pos": 15104424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135674.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135674.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079981.1" } ] } }, { "isoform_ac": "A0AAF6Z927-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9/entry#A0AAF6Z927-1", "sequence": { "sequence": "MNVLGGAPGHNPNRRAKMISIHSLSELERLKLQEAAYHELVARQFLSEFKPERALPTDRSNTFEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQVELRATMQMQEAAGPATSGRRRGNAVQRMFGRIRRIFSGRRDEPFLPREFTRRGRRGAVSADSLAELEGGALLLQTLQLSRISFPIGQRLLGSKRKMSLNPIAKQIPHVVEACCSFIEKHGLSTVGIFTLEYSEKRVRKLREEFDQGLDVVLDDSQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLQTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKVLHKVAENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGASAKRESRKTRLGIDHYVASVSVVRAMIDNWDVLFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSERIKMEEDALLSDPVETSAEARAAILGQSKPFDEGSSEEPAVPPGTARSHDDEEGAGNPLILEQDRPLLRVPREKEAKTGIGYFFP", "length": 517, "header": "tr|A0AAF6Z927-1|A0AAF6Z927_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 36 OS=Bos taurus OX=9913 GN=ARHGAP36 PE=4 SV=2 CANONICAL=A0AAA9S7R9-1" }, "locus": { "chromosome": "X", "start_pos": 15111683, "end_pos": 15101521, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028237.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028237.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028237.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028237.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" } ], "pmid": "" }, { "name": "positive regulation of intracellular signal transduction", "id": "GO:1902533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902533", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1043, "end_pos": 1045, "annotation": "n_glycosylation_sequon" }, { "start_pos": 722, "end_pos": 724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 972, "end_pos": 974, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R9" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 227, "end_pos": 427, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1043, "end_pos": 1045 }, { "start_pos": 722, "end_pos": 724 }, { "start_pos": 972, "end_pos": 974 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8Y9-1", "uniprot_ac": "A0AAA9S8Y9", "uniprot_id": "A0AAA9S8Y9_BOVIN", "mass": { "chemical_mass": 72993.0, "monoisotopic_mass": 72993.0 }, "refseq": {}, "gene_names": [ { "name": "RUFY3", "type": "recommended", "evidence": [ { "id": "A0AAA9S8Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ] } ], "protein_names": [ { "name": "RUN and FYVE domain containing 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S8Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RUFY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9", "locus": { "chromosome": "6", "start_pos": 86185301, "end_pos": 86092616, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016795", "url": "https://www.ensembl.org/id/ENSBTAG00000016795" } ] } } ], "crossref": [ { "id": "A0AAA9S8Y9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8Y9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016795", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016795", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15744", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15744", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17696", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17696", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514798", "url": "https://www.ncbi.nlm.nih.gov/gene/514798", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BNY5", "url": "https://www.orthodb.org/?gene=E1BNY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45956", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45956", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45956:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45956:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RWI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4R7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4R7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U064", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U064", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U064-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U064-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNY5", "url": "https://www.uniprot.org/uniprotkb/E1BNY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNY5-1", "url": "https://www.uniprot.org/uniprotkb/E1BNY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDSWEDLTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRLQSHPVDQQDQPLPSEKPPKYCQLCQEDCSLTKNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS", "length": 640, "header": "tr|A0AAA9S8Y9-1|A0AAA9S8Y9_BOVIN Isoform 1 of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=2 CANONICAL=A0AAA9S8Y9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9RWI2-1", "sequence": { "sequence": "MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMAAVSPCGSTGSAVALRKATEVLSAMPGRLQPNKECM", "length": 556, "header": "tr|A0AAA9RWI2-1|A0AAA9S8Y9_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=1 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184164, "end_pos": 86113150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093314.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093314.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075477.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075477.1" } ] } }, { "isoform_ac": "A0AAA9S8Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9S8Y9-1", "sequence": { "sequence": "MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDSWEDLTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRLQSHPVDQQDQPLPSEKPPKYCQLCQEDCSLTKNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS", "length": 640, "header": "tr|A0AAA9S8Y9-1|A0AAA9S8Y9_BOVIN Isoform 1 of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=2 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184297, "end_pos": 86113150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090863.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090863.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079829.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079829.2" } ] } }, { "isoform_ac": "A0AAA9SSG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9SSG8-1", "sequence": { "sequence": "MAETSPPPTAGAESCSEEPARGGKQRPEEPRRAPAGGADREDEAGPPLASPAGQSEPGSPVAAPFFLLYPGDGGAGFVARPPPQQQRSWRTPPSPGSPLPFLLLNYPSGGGGGGGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRLQSHPVDQQDQPLPSEKPPKYCQLCQEDCSLTKNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS", "length": 640, "header": "tr|A0AAA9SSG8-1|A0AAA9SSG8_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=1 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184297, "end_pos": 86092957, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094105.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094105.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086935.1" } ] } }, { "isoform_ac": "A0AAA9SU19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9SU19-1", "sequence": { "sequence": "MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRMYVGTAEEPSVTSVQQTNCLFLQVSSLSEFAIPATSI", "length": 579, "header": "tr|A0AAA9SU19-1|A0AAA9SU19_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=2 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184268, "end_pos": 86113150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126657.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126657.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089912.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089912.2" } ] } }, { "isoform_ac": "A0AAA9T4R7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9T4R7-1", "sequence": { "sequence": "MAETSPPPTAGAESCSEEPARGGKQRPEEPRRAPAGGADREDEAGPPLASPAGQSEPGSPVAAPFFLLYPGDGGAGFVARPPPQQQRSWRTPPSPGSPLPFLLLNYPSGGGGGGGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH", "length": 527, "header": "tr|A0AAA9T4R7-1|A0AAA9T4R7_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=1 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86173090, "end_pos": 86092957, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117935.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117935.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090720.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090720.1" } ] } }, { "isoform_ac": "A0AAA9T5Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9T5Y4-1", "sequence": { "sequence": "MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRLQSHPVDQQDQPLPSEKPPKYCQLCQEDCSLTKNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS", "length": 622, "header": "tr|A0AAA9T5Y4-1|A0AAA9T5Y4_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=2 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184297, "end_pos": 86113150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125285.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125285.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091173.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091173.2" } ] } }, { "isoform_ac": "A0AAA9T7Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9T7Z9-1", "sequence": { "sequence": "MSLFISRGGEDSWEDLTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMAAVSPCGSTGSAVALRKATEVLSAMPGRLQPNKECM", "length": 525, "header": "tr|A0AAA9T7Z9-1|A0AAA9T7Z9_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=2 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184164, "end_pos": 86094795, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111750.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111750.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092917.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092917.2" } ] } }, { "isoform_ac": "A0AAA9TWI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9TWI7-1", "sequence": { "sequence": "MLTKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRLQSHPVDQQDQPLPSEKPPKYCQLCQEDCSLTKNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS", "length": 609, "header": "tr|A0AAA9TWI7-1|A0AAA9TWI7_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=1 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184297, "end_pos": 86108086, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089964.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089964.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103014.1" } ] } }, { "isoform_ac": "A0AAA9U064-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#A0AAA9U064-1", "sequence": { "sequence": "MAETSPPPTAGAESCSEEPARGGKQRPEEPRRAPAGGADREDEAGPPLASPAGQSEPGSPVAAPFFLLYPGDGGAGFVARPPPQQQRSWRTPPSPGSPLPFLLLNYPSGGGGGGGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS", "length": 625, "header": "tr|A0AAA9U064-1|A0AAA9U064_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=1 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86184297, "end_pos": 86092957, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103269.1" } ] } }, { "isoform_ac": "E1BNY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9/entry#E1BNY5-1", "sequence": { "sequence": "MAETSPPPTAGAESCSEEPARGGKQRPEEPRRAPAGGADREDEAGPPLASPAGQSEPGSPVAAPFFLLYPGDGGAGFVARPPPQQQRSWRTPPSPGSPLPFLLLNYPSGGGGGGGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKPDRTSEGQALSEARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEALTRQRNHLELELKQERERRLQNSRSIPGKGSQKPEEPKMDGKHKIQEENVKLNKPLEESHRISRCPPKSHRSIVSYARKTAA", "length": 621, "header": "tr|E1BNY5-1|A0AAA9S8Y9_BOVIN Computationally mapped isoform of RUN and FYVE domain containing 3 OS=Bos taurus OX=9913 GN=RUFY3 PE=4 SV=3 CANONICAL=A0AAA9S8Y9-1" }, "locus": { "chromosome": "6", "start_pos": 86182245, "end_pos": 86092957, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022343.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022343.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022343.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022343.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "endolysosome", "id": "GO:0036019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036019", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "dynactin binding", "id": "GO:0034452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034452", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "positive regulation of retrograde axon cargo transport", "id": "GO:2001019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001019", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" }, { "name": "regulation of axonogenesis", "id": "GO:0050770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" }, { "id": "PS50178", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FYVE-type", "eco_id": "ECO_0000259", "start_pos": 576, "end_pos": 632, "start_aa": "Glu", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y9" }, { "id": "PS50826", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50826" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RUN", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 245, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 293, "end_pos": 295 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S957-1", "uniprot_ac": "A0AAA9S957", "uniprot_id": "A0AAA9S957_BOVIN", "mass": { "chemical_mass": 61237.0, "monoisotopic_mass": 61237.0 }, "refseq": {}, "gene_names": [ { "name": "NRBP1", "type": "recommended", "evidence": [ { "id": "A0AAA9S957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ] } ], "protein_names": [ { "name": "Nuclear receptor-binding protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NRBP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957", "locus": { "chromosome": "11", "start_pos": 72234502, "end_pos": 72247034, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018153", "url": "https://www.ensembl.org/id/ENSBTAG00000018153" } ] } } ], "crossref": [ { "id": "A0AAA9S957", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S957", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14034", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14034", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532919", "url": "https://www.ncbi.nlm.nih.gov/gene/532919", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S0L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S696", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S696", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S696-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S696-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S957-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R866", "url": "https://www.uniprot.org/uniprotkb/F6R866", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R866-1", "url": "https://www.uniprot.org/uniprotkb/F6R866-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEGEPQTVLSSGSDPKVESSSSTPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEVSVFPFYSPSLQMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS", "length": 547, "header": "tr|A0AAA9S957-1|A0AAA9S957_BOVIN Isoform 1 of Nuclear receptor-binding protein OS=Bos taurus OX=9913 GN=NRBP1 PE=4 SV=1 CANONICAL=A0AAA9S957-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957/entry#A0AAA9S0L2-1", "sequence": { "sequence": "MSEGEPQTVLSSGSDPKVESSSSTPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHMRTSRSWRLSWCSWASLVRLTRAD", "length": 485, "header": "tr|A0AAA9S0L2-1|A0AAA9S957_BOVIN Computationally mapped isoform of Nuclear receptor-binding protein OS=Bos taurus OX=9913 GN=NRBP1 PE=4 SV=1 CANONICAL=A0AAA9S957-1" }, "locus": { "chromosome": "11", "start_pos": 72244131, "end_pos": 72235033, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121019.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121019.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077173.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077173.1" } ] } }, { "isoform_ac": "A0AAA9S696-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957/entry#A0AAA9S696-1", "sequence": { "sequence": "MTDEGLSVCSSMSEGEPQTVLSSGSDPKVESSSSTPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS", "length": 546, "header": "tr|A0AAA9S696-1|A0AAA9S696_BOVIN Computationally mapped isoform of Nuclear receptor-binding protein OS=Bos taurus OX=9913 GN=NRBP1 PE=4 SV=1 CANONICAL=A0AAA9S957-1" }, "locus": { "chromosome": "11", "start_pos": 72246006, "end_pos": 72234947, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124124.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124124.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078817.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078817.1" } ] } }, { "isoform_ac": "A0AAA9S957-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957/entry#A0AAA9S957-1", "sequence": { "sequence": "MSEGEPQTVLSSGSDPKVESSSSTPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEVSVFPFYSPSLQMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS", "length": 547, "header": "tr|A0AAA9S957-1|A0AAA9S957_BOVIN Isoform 1 of Nuclear receptor-binding protein OS=Bos taurus OX=9913 GN=NRBP1 PE=4 SV=1 CANONICAL=A0AAA9S957-1" }, "locus": { "chromosome": "11", "start_pos": 72244131, "end_pos": 72234947, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082604.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082604.1" } ] } }, { "isoform_ac": "F6R866-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957/entry#F6R866-1", "sequence": { "sequence": "MSEGEPQTVLSSGSDPKVESSSSTPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVFHRIFANVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS", "length": 543, "header": "tr|F6R866-1|F6R866_BOVIN Computationally mapped isoform of Nuclear receptor-binding protein OS=Bos taurus OX=9913 GN=NRBP1 PE=4 SV=1 CANONICAL=A0AAA9S957-1" }, "locus": { "chromosome": "11", "start_pos": 72244131, "end_pos": 72234947, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024159.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024159.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024159.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024159.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 24, "start_aa": "Thr", "end_pos": 24, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr24", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S957", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 535, "end_pos": 537, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S957" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 339, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 24 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 535, "end_pos": 537 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9I8-1", "uniprot_ac": "A0AAA9S9I8", "uniprot_id": "A0AAA9S9I8_BOVIN", "mass": { "chemical_mass": 117452.0, "monoisotopic_mass": 117452.0 }, "refseq": {}, "gene_names": [ { "name": "R3HDM2", "type": "recommended", "evidence": [ { "id": "A0AAA9S9I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8" } ] } ], "protein_names": [ { "name": "R3H domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S9I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "R3HDM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8", "locus": { "chromosome": "5", "start_pos": 56191524, "end_pos": 56039314, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018361", "url": "https://www.ensembl.org/id/ENSBTAG00000018361" } ] } } ], "crossref": [ { "id": "A0AAA9S9I8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9I8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02642", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02642", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613499", "url": "https://www.ncbi.nlm.nih.gov/gene/613499", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15672", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15672", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15672:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15672:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S3X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T476", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T476", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T476-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T476-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5J0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5J0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5J0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTSVVVVPGLSCSAACGIFLYQGSNHVSPWQVDSNTEPPGKPWRLDLLLICDTIPALNSWRLNIYSGVHRGYCILLKKMSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQIRVPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 1068, "header": "tr|A0AAA9S9I8-1|A0AAA9S9I8_BOVIN Isoform 1 of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=1 CANONICAL=A0AAA9S9I8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#A0AAA9S3X5-1", "sequence": { "sequence": "MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPSNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQTGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 937, "header": "tr|A0AAA9S3X5-1|A0AAA9S9I8_BOVIN Computationally mapped isoform of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=2 CANONICAL=A0AAA9S9I8-1" }, "locus": { "chromosome": "5", "start_pos": 56190818, "end_pos": 56146111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126663.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126663.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076816.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076816.2" } ] } }, { "isoform_ac": "A0AAA9S9I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#A0AAA9S9I8-1", "sequence": { "sequence": "MRTSVVVVPGLSCSAACGIFLYQGSNHVSPWQVDSNTEPPGKPWRLDLLLICDTIPALNSWRLNIYSGVHRGYCILLKKMSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQIRVPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 1068, "header": "tr|A0AAA9S9I8-1|A0AAA9S9I8_BOVIN Isoform 1 of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=1 CANONICAL=A0AAA9S9I8-1" }, "locus": { "chromosome": "5", "start_pos": 56190818, "end_pos": 56039459, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078803.1" } ] } }, { "isoform_ac": "A0AAA9T476-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#A0AAA9T476-1", "sequence": { "sequence": "MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQTGQNGYLNDIRLSKEAFSSSSHKRRQIFRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQPVPALQPSPQPVQFSPGSCPQVLLPVSPPQQYNMADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 1009, "header": "tr|A0AAA9T476-1|A0AAA9T476_BOVIN Computationally mapped isoform of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=1 CANONICAL=A0AAA9S9I8-1" }, "locus": { "chromosome": "5", "start_pos": 56190818, "end_pos": 56146111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132037.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132037.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093594.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093594.1" } ] } }, { "isoform_ac": "A0AAA9TEC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#A0AAA9TEC1-1", "sequence": { "sequence": "MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQTGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQPVPALQPSPQPVQFSPGSCPQVLLPVSPPQQYNMADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 991, "header": "tr|A0AAA9TEC1-1|A0AAA9TEC1_BOVIN Computationally mapped isoform of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=2 CANONICAL=A0AAA9S9I8-1" }, "locus": { "chromosome": "5", "start_pos": 56190818, "end_pos": 56146111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103173.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103173.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096501.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096501.2" } ] } }, { "isoform_ac": "A0AAA9TJW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#A0AAA9TJW6-1", "sequence": { "sequence": "MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQSYEFLFDKRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQTGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 965, "header": "tr|A0AAA9TJW6-1|A0AAA9TJW6_BOVIN Computationally mapped isoform of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=1 CANONICAL=A0AAA9S9I8-1" }, "locus": { "chromosome": "5", "start_pos": 56190818, "end_pos": 56146111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095407.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095407.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097464.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097464.1" } ] } }, { "isoform_ac": "A0AAF6Z5J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8/entry#A0AAF6Z5J0-1", "sequence": { "sequence": "MDRDLLLICDTIPALNSWRLNIYSGVHRGYCILLKKMSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKESEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSAPFVDGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKVPRRMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQIRVPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYSPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSNQRSGMGGQMQGLVVQYTPLPSYQVPVGNDSQNVVQPPFQQPMLVPASQSVQGALPAGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPESSPQANTQMSSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSAYSVHQGQSGLKHGNRSKRQALKSASTDLGTTDVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNGGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ", "length": 1025, "header": "tr|A0AAF6Z5J0-1|A0AAF6Z5J0_BOVIN Computationally mapped isoform of R3H domain containing 2 OS=Bos taurus OX=9913 GN=R3HDM2 PE=4 SV=1 CANONICAL=A0AAA9S9I8-1" }, "locus": { "chromosome": "5", "start_pos": 56190818, "end_pos": 56066085, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024431.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024431.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024431.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024431.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 512, "start_aa": "Thr", "end_pos": 512, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr512", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1036, "end_pos": 1038, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1042, "end_pos": 1044, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 582, "end_pos": 584, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 909, "end_pos": 911, "annotation": "n_glycosylation_sequon" }, { "start_pos": 936, "end_pos": 938, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8" }, { "id": "PS51061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "R3H", "eco_id": "ECO_0000259", "start_pos": 248, "end_pos": 311, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I8" }, { "id": "PS51673", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51673" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUZ", "eco_id": "ECO_0000259", "start_pos": 312, "end_pos": 382, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 512 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1036, "end_pos": 1038 }, { "start_pos": 1042, "end_pos": 1044 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 582, "end_pos": 584 }, { "start_pos": 708, "end_pos": 710 }, { "start_pos": 752, "end_pos": 754 }, { "start_pos": 84, "end_pos": 86 }, { "start_pos": 909, "end_pos": 911 }, { "start_pos": 936, "end_pos": 938 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5T9-1", "uniprot_ac": "A0AAA9S5T9", "uniprot_id": "A0AAA9S5T9_BOVIN", "mass": { "chemical_mass": 52663.0, "monoisotopic_mass": 52663.0 }, "refseq": {}, "gene_names": [ { "name": "ELAVL1", "type": "recommended", "evidence": [ { "id": "A0AAA9S5T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ] } ], "protein_names": [ { "name": "ELAV-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S5T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELAVL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9", "locus": { "chromosome": "7", "start_pos": 16715069, "end_pos": 16752623, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000613", "url": "https://www.ensembl.org/id/ENSBTAG00000000613" } ] } } ], "crossref": [ { "id": "A0AAA9S5T9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12653", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12653", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12773", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12773", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5E0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5E0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QUM9", "url": "https://www.uniprot.org/uniprotkb/F6QUM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QUM9-1", "url": "https://www.uniprot.org/uniprotkb/F6QUM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRTKGATLRPQPPVGLRGPGHSWPSPRPSLATRASLPAAELFAGGASRKSRPRRAPRGAATATRANEKRAVADAGQWARAPGGRVRAAGRSGSCALRRSRRRRRRRRRYRQRYRGRAEPLAPRRRRPPAQEQPRAHPPASRFFKKNTMSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRNMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK", "length": 474, "header": "tr|A0AAA9S5T9-1|A0AAA9S5T9_BOVIN Isoform 1 of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL1 PE=3 SV=1 CANONICAL=A0AAA9S5T9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9/entry#A0AAA9S5T9-1", "sequence": { "sequence": "MPRTKGATLRPQPPVGLRGPGHSWPSPRPSLATRASLPAAELFAGGASRKSRPRRAPRGAATATRANEKRAVADAGQWARAPGGRVRAAGRSGSCALRRSRRRRRRRRRYRQRYRGRAEPLAPRRRRPPAQEQPRAHPPASRFFKKNTMSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRNMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK", "length": 474, "header": "tr|A0AAA9S5T9-1|A0AAA9S5T9_BOVIN Isoform 1 of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL1 PE=3 SV=1 CANONICAL=A0AAA9S5T9-1" }, "locus": { "chromosome": "7", "start_pos": 16752493, "end_pos": 16716298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094069.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094069.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081295.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081295.1" } ] } }, { "isoform_ac": "A0AAA9T5E0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9/entry#A0AAA9T5E0-1", "sequence": { "sequence": "MSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRNMTQKDVEDMFSRFGRIINSRVLVDQTTVTPAMRTESQ", "length": 153, "header": "tr|A0AAA9T5E0-1|A0AAA9T5E0_BOVIN Computationally mapped isoform of ELAV like RNA binding protein 1 OS=Bos taurus OX=9913 GN=ELAVL1 PE=4 SV=1 CANONICAL=A0AAA9S5T9-1" }, "locus": { "chromosome": "7", "start_pos": 16737706, "end_pos": 16723896, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129298.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129298.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090952.1" } ] } }, { "isoform_ac": "F6QUM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9/entry#F6QUM9-1", "sequence": { "sequence": "MPGSGGTGLLDTVKKFFKKNTMSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRNMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK", "length": 347, "header": "tr|F6QUM9-1|F6QUM9_BOVIN Computationally mapped isoform of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL1 PE=3 SV=1 CANONICAL=A0AAA9S5T9-1" }, "locus": { "chromosome": "7", "start_pos": 16748416, "end_pos": 16716298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000805.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000805.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000805.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000805.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of miRNA-mediated gene silencing", "id": "GO:0060965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA stabilization", "id": "GO:0070935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070935", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "regulation of stem cell population maintenance", "id": "GO:2000036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "lncRNA-mediated post-transcriptional gene silencing", "id": "GO:0000512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "regulation of mRNA stability", "id": "GO:0043488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043488", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "miRNA binding", "id": "GO:0035198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "mRNA 3'-UTR AU-rich region binding", "id": "GO:0035925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "lncRNA binding", "id": "GO:0106222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T9" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 168, "end_pos": 246, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 178, "end_pos": 180 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 470, "end_pos": 472 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5W8-1", "uniprot_ac": "A0AAA9S5W8", "uniprot_id": "A0AAA9S5W8_BOVIN", "mass": { "chemical_mass": 35003.0, "monoisotopic_mass": 35003.0 }, "refseq": {}, "gene_names": [ { "name": "RAB12", "type": "recommended", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ], "protein_names": [ { "name": "Ras-related protein Rab-12", "type": "recommended", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8", "locus": { "chromosome": "24", "start_pos": 41101417, "end_pos": 41080659, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010356", "url": "https://www.ensembl.org/id/ENSBTAG00000010356" } ] } } ], "crossref": [ { "id": "A0AAA9S5W8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5W8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04120", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04120", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47980", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47980", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5W8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM49", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLPLLRSSCFPSSSPGGGGGGGSGRGGGGGADAGGRPAAQLQRGAHGPLGPLERALAQPGAEPRRLAEAEGARGLGGPHACMDPGAALHRRPAGGGGLGAGSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQIAGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDMLRNELSNSILSLQPEPEIPPELPPPRPHVRCC", "length": 326, "header": "tr|A0AAA9S5W8-1|A0AAA9S5W8_BOVIN Isoform 1 of Ras-related protein Rab-12 OS=Bos taurus OX=9913 GN=RAB12 PE=3 SV=1 CANONICAL=A0AAA9S5W8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5W8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8/entry#A0AAA9S5W8-1", "sequence": { "sequence": "MLLPLLRSSCFPSSSPGGGGGGGSGRGGGGGADAGGRPAAQLQRGAHGPLGPLERALAQPGAEPRRLAEAEGARGLGGPHACMDPGAALHRRPAGGGGLGAGSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQIAGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDMLRNELSNSILSLQPEPEIPPELPPPRPHVRCC", "length": 326, "header": "tr|A0AAA9S5W8-1|A0AAA9S5W8_BOVIN Isoform 1 of Ras-related protein Rab-12 OS=Bos taurus OX=9913 GN=RAB12 PE=3 SV=1 CANONICAL=A0AAA9S5W8-1" }, "locus": { "chromosome": "24", "start_pos": 41100328, "end_pos": 41080858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115730.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115730.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080613.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080613.1" } ] } }, { "isoform_ac": "A0AAF6DM49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8/entry#A0AAF6DM49-1", "sequence": { "sequence": "AAARSPRPAGAARARARPARGRAAALGGGRGGAGARGAACVHGSGRRAAQAARGRRRVGRGLPGAVGRPGPPAQAAPQAGRLQAAGHHHRLPRRGQDQPDGALHRRHFLRGLQVHRGDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQIAGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDMLRNELSNSILSLQPEPEIPPELPPPRPHVRCC", "length": 265, "header": "tr|A0AAF6DM49-1|A0AAF6DM49_BOVIN Computationally mapped isoform of small monomeric GTPase OS=Bos taurus OX=9913 GN=RAB12 PE=3 SV=1 CANONICAL=A0AAA9S5W8-1" }, "locus": { "chromosome": "24", "start_pos": 41100328, "end_pos": 41080980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013671.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013671.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013671.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013671.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" }, { "name": "Rab protein signal transduction", "id": "GO:0032482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032482", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5W8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5X6-1", "uniprot_ac": "A0AAA9S5X6", "uniprot_id": "A0AAA9S5X6_BOVIN", "mass": { "chemical_mass": 70678.0, "monoisotopic_mass": 70678.0 }, "refseq": { "ac": "XP_024844207", "name": "ralBP1-associated Eps domain-containing protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844207" }, "gene_names": [ { "name": "REPS2", "type": "recommended", "evidence": [ { "id": "A0AAA9S5X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ] }, { "name": "REPS2", "type": "synonym", "evidence": [ { "id": "XP_024844207", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844207" } ] } ], "protein_names": [ { "name": "RALBP1 associated Eps domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S5X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6/entry#names_and_taxonomy" } ] }, { "name": "ralBP1-associated Eps domain-containing protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024844207", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844207" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REPS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6", "locus": { "chromosome": "X", "start_pos": 126294545, "end_pos": 126533895, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031261", "url": "https://www.ensembl.org/id/ENSBTAG00000031261" } ] } } ], "crossref": [ { "id": "A0AAA9S5X6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5X6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031261", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031261", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00052", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00052", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526887", "url": "https://www.ncbi.nlm.nih.gov/gene/526887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526887", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526887", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MZ73", "url": "https://www.orthodb.org/?gene=F1MZ73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11216:SF64", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11216:SF64", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024844207", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844207", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5X6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ73", "url": "https://www.uniprot.org/uniprotkb/F1MZ73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ73-1", "url": "https://www.uniprot.org/uniprotkb/F1MZ73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAAAGGLCGSGPPLLLSEGEQQCYSELFARCAGASGGGPGPGPPEAARAAPGAATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQSGLPVRIESIKCELPLPRFMMSKTDAEIRFGNTAELHGTKVQIPYLITEKNTFKRIDDEDKQQETQSPSMSPLASPPSSPPHYQRVPLSHGYSKLRSSTEQMHSAPYEARQPLVQPEGPSTGGPGAKPPRHQASLIRSFSVERELQDNSTSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWECALFDSYSESIPANQQPRDLNRMEKLSIKDMADFPVPTQDVTGDDKQALKSATDEALPKDMSEDSATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPASKSGLLPPPPALPPRPCPSQSEQASEAEVHPQLNRAPSQAAESSPTKKEIPYSQPPSKPIRRKFRPENQATENQEPSTTVGGPASVATVKPHPAVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL", "length": 648, "header": "tr|A0AAA9S5X6-1|A0AAA9S5X6_BOVIN Isoform 1 of RALBP1 associated Eps domain containing 2 OS=Bos taurus OX=9913 GN=REPS2 PE=4 SV=1 CANONICAL=A0AAA9S5X6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5X6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6/entry#A0AAA9S5X6-1", "sequence": { "sequence": "MEAAAGGLCGSGPPLLLSEGEQQCYSELFARCAGASGGGPGPGPPEAARAAPGAATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQSGLPVRIESIKCELPLPRFMMSKTDAEIRFGNTAELHGTKVQIPYLITEKNTFKRIDDEDKQQETQSPSMSPLASPPSSPPHYQRVPLSHGYSKLRSSTEQMHSAPYEARQPLVQPEGPSTGGPGAKPPRHQASLIRSFSVERELQDNSTSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWECALFDSYSESIPANQQPRDLNRMEKLSIKDMADFPVPTQDVTGDDKQALKSATDEALPKDMSEDSATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPASKSGLLPPPPALPPRPCPSQSEQASEAEVHPQLNRAPSQAAESSPTKKEIPYSQPPSKPIRRKFRPENQATENQEPSTTVGGPASVATVKPHPAVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL", "length": 648, "header": "tr|A0AAA9S5X6-1|A0AAA9S5X6_BOVIN Isoform 1 of RALBP1 associated Eps domain containing 2 OS=Bos taurus OX=9913 GN=REPS2 PE=4 SV=1 CANONICAL=A0AAA9S5X6-1" }, "locus": { "chromosome": "X", "start_pos": 126533696, "end_pos": 126295549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077564.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077564.1" } ] } }, { "isoform_ac": "A0AAA9SRM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6/entry#A0AAA9SRM9-1", "sequence": { "sequence": "MEAAAGGLCGSGPPLLLSEGEQQCYSELFARCAGASGGGPGPGPPEAARAAPGAATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQSGLPVRIESIKCELPLPRFMMSKTDAEIRFGNTAELHGTKVQIPYLITEKNTFKRIDDEDKQQETQSPSMSPLASPPSSPPHYQRVPLSHGYSKLRSSTEQMHSAPYEARQPLVQPEGPSTGGPGAKPPRHQASLIRSFSVERELQDNSTSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWECALFDSYSESIPANQQPRDLNRMEKLSIKDMADFPVPTQDVTGDDKQALKSATDEALPKDMSEDSATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPASKSGLLPPPPALPPRPCPSQISHHIVNSEPSTQLKPPAQLPKYGDFRLQKQSEQASEAEVHPQLNRAPSQAAESSPTKKEIPYSQPPSKPIRRKFRPENQATENQEPSTTVGGPASVATVKPHPAVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL", "length": 679, "header": "tr|A0AAA9SRM9-1|A0AAA9SRM9_BOVIN Computationally mapped isoform of RALBP1 associated Eps domain containing 2 OS=Bos taurus OX=9913 GN=REPS2 PE=4 SV=1 CANONICAL=A0AAA9S5X6-1" }, "locus": { "chromosome": "X", "start_pos": 126533696, "end_pos": 126295549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098174.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098174.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085628.1" } ] } }, { "isoform_ac": "F1MZ73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6/entry#F1MZ73-1", "sequence": { "sequence": "MEAAAGGLCGSGPPLLLSEGEQQCYSELFARCAGASGGGPGPGPPEAARAAPGAATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYVALKLIAAAQSGLPVRIESIKCELPLPRFMMSKTDAEIRFGNTAELHGTKVQIPYLITEKNTFKRIDDEDKQQETQSPSMSPLASPPSSPPHYQRVPLSHGYSKLRSSTEQMHSAPYEARQPLVQPEGPSTGGPGAKPPRHQASLIRSFSVERELQDNSTSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWECALFDSYSESIPANQQPRDLNRMEKLSIKDMADFPVPTQDVTGDDKQALKSATDEALPKDMSEDSATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPASKSGLLPPPPALPPRPCPSQSEQASEAEVHPQLNRAPSQAAESSPTKKEIPYSQPPSKPIRRKFRPENQATENQEPSTTVGGPASVATVKPHPAVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKVLGVELSTPFQSSPDIP", "length": 643, "header": "tr|F1MZ73-1|F1MZ73_BOVIN Computationally mapped isoform of RALBP1 associated Eps domain containing 2 OS=Bos taurus OX=9913 GN=REPS2 PE=4 SV=4 CANONICAL=A0AAA9S5X6-1" }, "locus": { "chromosome": "X", "start_pos": 126533696, "end_pos": 126312745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016315.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016315.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016315.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016315.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 467, "start_aa": "Thr", "end_pos": 467, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr467", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:526887", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526887", "resource": "KEGG Pathway" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 303, "end_pos": 338, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X6" }, { "id": "PS50031", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50031" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EH", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 122, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 467 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5X8-1", "uniprot_ac": "A0AAA9S5X8", "uniprot_id": "A0AAA9S5X8_BOVIN", "mass": { "chemical_mass": 182276.0, "monoisotopic_mass": 182276.0 }, "refseq": {}, "gene_names": [ { "name": "SMARCA4", "type": "recommended", "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ] } ], "protein_names": [ { "name": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMARCA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8", "locus": { "chromosome": "7", "start_pos": 15515086, "end_pos": 15424807, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019220", "url": "https://www.ensembl.org/id/ENSBTAG00000019220" } ] } } ], "crossref": [ { "id": "cd05516", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05516", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18793", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18793", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "414274", "url": "https://www.ncbi.nlm.nih.gov/gene/414274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10799", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10799", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07529", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07529", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07533", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07533", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08880", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08880", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z674", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z674", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z674-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z674-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFPRRLLSAAPVKMSTPDPALGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSIMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYTQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQPQMPALPPPSVSATGPGPSPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGPSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED", "length": 1620, "header": "tr|A0AAA9S5X8-1|A0AAA9S5X8_BOVIN Isoform 1 of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 OS=Bos taurus OX=9913 GN=SMARCA4 PE=3 SV=1 CANONICAL=A0AAA9S5X8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8/entry#A0AAA9S5X8-1", "sequence": { "sequence": "MEFPRRLLSAAPVKMSTPDPALGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSIMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYTQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQPQMPALPPPSVSATGPGPSPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGPSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED", "length": 1620, "header": "tr|A0AAA9S5X8-1|A0AAA9S5X8_BOVIN Isoform 1 of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 OS=Bos taurus OX=9913 GN=SMARCA4 PE=3 SV=1 CANONICAL=A0AAA9S5X8-1" }, "locus": { "chromosome": "7", "start_pos": 15514612, "end_pos": 15428670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078711.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078711.1" } ] } }, { "isoform_ac": "A0AAF6Z674-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8/entry#A0AAF6Z674-1", "sequence": { "sequence": "MGRLLSAAPVKMSTPDPALGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSIMGPSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYTQMKGMGMRSGGHAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQPQMPALPPPSVSATGPGPSPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGPSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED", "length": 1617, "header": "tr|A0AAF6Z674-1|A0AAF6Z674_BOVIN Computationally mapped isoform of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 OS=Bos taurus OX=9913 GN=SMARCA4 PE=3 SV=1 CANONICAL=A0AAA9S5X8-1" }, "locus": { "chromosome": "7", "start_pos": 15514612, "end_pos": 15427710, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025598.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025598.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025598.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025598.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "positive regulation of glucose mediated signaling pathway", "id": "GO:1902661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902661", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "neural retina development", "id": "GO:0003407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003407", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "positive regulation of signal transduction by p53 class mediator", "id": "GO:1901798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901798", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "nucleosome disassembly", "id": "GO:0006337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006337", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "host-mediated activation of viral transcription", "id": "GO:0043923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "id": "GO:1901838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901838", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "positive regulation of Wnt signaling pathway", "id": "GO:0030177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "positive regulation of miRNA transcription", "id": "GO:1902895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902895", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "negative regulation of androgen receptor signaling pathway", "id": "GO:0060766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060766", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 13, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "DNA polymerase binding", "id": "GO:0070182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070182", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "Tat protein binding", "id": "GO:0030957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030957", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "nuclear androgen receptor binding", "id": "GO:0050681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050681", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "RNA polymerase I core promoter sequence-specific DNA binding", "id": "GO:0001164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001164", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "ATP-dependent activity, acting on DNA", "id": "GO:0008094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "transcription coregulator binding", "id": "GO:0001221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001221", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "npBAF complex", "id": "GO:0071564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071564", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1430, "end_pos": 1432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" }, { "id": "PS50014", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bromo", "eco_id": "ECO_0000259", "start_pos": 1450, "end_pos": 1520, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" }, { "id": "PS51204", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51204" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HSA", "eco_id": "ECO_0000259", "start_pos": 466, "end_pos": 538, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 772, "end_pos": 937, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 1090, "end_pos": 1252, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S5X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X8" }, { "id": "PS51666", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51666" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "QLQ", "eco_id": "ECO_0000259", "start_pos": 185, "end_pos": 220, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1430, "end_pos": 1432 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 569, "end_pos": 571 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5Y6-1", "uniprot_ac": "A0AAA9S5Y6", "uniprot_id": "A0AAA9S5Y6_BOVIN", "mass": { "chemical_mass": 11432.0, "monoisotopic_mass": 11432.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "ATP synthase F(0) complex subunit g, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9S5Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6/entry#names_and_taxonomy" } ] }, { "name": "ATPase subunit g", "type": "synonym", "evidence": [ { "id": "A0AAA9S5Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Subunit g, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6#function" }, { "database": "UniProtKB", "id": "PIRNR017835", "url": "https://www.uniprot.org/uniprotkb/PIRNR017835#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S5Y6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5Y6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016702", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016702", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KSGAWKN", "url": "https://omabrowser.org/oma/group/KSGAWKN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12386", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12386", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04718", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04718", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQFVRNLAEKALALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPTAIQSLKKIINSAKTGSFKQLTVKEALLNGLVATEVWMWFYVGKIIGKRGIIGYDV", "length": 103, "header": "tr|A0AAA9S5Y6-1|A0AAA9S5Y6_BOVIN Isoform 1 of ATP synthase F(0) complex subunit g, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S5Y6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6/entry#A0AAA9S5Y6-1", "sequence": { "sequence": "MAQFVRNLAEKALALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPTAIQSLKKIINSAKTGSFKQLTVKEALLNGLVATEVWMWFYVGKIIGKRGIIGYDV", "length": 103, "header": "tr|A0AAA9S5Y6-1|A0AAA9S5Y6_BOVIN Isoform 1 of ATP synthase F(0) complex subunit g, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S5Y6-1" }, "locus": { "chromosome": "14", "start_pos": 42882390, "end_pos": 42882082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105958.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105958.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077574.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077574.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 42, "start_aa": "Thr", "end_pos": 42, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr42", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q9VKM3-1", "protein_name": "ATP synthase subunit g", "gene_name": "ATPsynG", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASLATKGSGLVNRLLTQARPQLDVFLKYAKVELTPPTPADIPAIRQGLGNIIKGAKTGAYKNLTVREAWLNTLVTAEVIFWFYIGECIGKRHIVGYNV", "length": 99 }, "evidence": [ { "id": "A0AAA9S5Y6", "url": "https://omabrowser.org/oma/group/A0AAA9S5Y6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6" } ], "pmid": "" }, { "name": "proton-transporting ATP synthase complex", "id": "GO:0045259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "proton transmembrane transporter activity", "id": "GO:0015078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proton motive force-driven ATP synthesis", "id": "GO:0015986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 42 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5Z1-1", "uniprot_ac": "A0AAA9S5Z1", "uniprot_id": "A0AAA9S5Z1_BOVIN", "mass": { "chemical_mass": 86771.0, "monoisotopic_mass": 86771.0 }, "refseq": {}, "gene_names": [ { "name": "PCDHB11", "type": "recommended", "evidence": [ { "id": "A0AAA9S5Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1" } ] } ], "protein_names": [ { "name": "Protocadherin beta 11", "type": "synonym", "evidence": [ { "id": "A0AAA9S5Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDHB11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1", "locus": { "chromosome": "7", "start_pos": 52341712, "end_pos": 52338792, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065893", "url": "https://www.ensembl.org/id/ENSBTAG00000065893" } ] } } ], "crossref": [ { "id": "A0AAA9S5Z1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5Z1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELGKGNPQQIRQVLLFFVFLGGSLVCSETWRYSVAEETEIGSFIGNVVKDIGLGVEDLAARGARVIFDDYKPHLRLDLQTGNLLLNEQPDREALCDLTEPCILHFQVLLENPLQFFRAELWVEDINDHTPTFTNKHILLKISESTAPGTSFQMDSAQDLDVGKNGVQNYTLNPNLHFHLKLQDSEDGRKYPELLLDQPLDREKEPELRLTLTALDGGSPARSGTALVRVLVLDINDNAPQFERSVYEVPIPENSPLDFLVVRVSATDLDAGINGELSYSFSHVSRDIQKTFEIHPIFGEVRLKAFLDFELLQSYTINIQAIDGGGLSGKSVILVSVVDVNDNPPEVVVTSLTSPIPENSSPEMVVAVFSLRDQDSGDNGRMVCSIQDNLPFLLKPNFKNFYTLETESPLDRESKAEYIITITVTDMGTPRLKTEHNITVLVSDVNDNAPTFTQTSYTLWVRENNSPALHIGSVSATDTDAGANAQVTYSLLPPPDPLVPLASLVSINPDNGHLFALTSLDYEALRAFEFRVGATDRGSPALSSQALVRVLVADANDNAPFVLYPLQNASAPCTELVPRAAEPGYLVTKVVAVDGDAGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAPKQRLVVLVKDNGEPPLSASVTLHVLLVDGFSQPYLPAPEAEAAAAAPADPLTVYLVVALASVSSLFLFSVLVFVAVRLCRRAGATSAGRCPVLEGHFPGHLVDVSGTGTLSQSYQYEVCLTGGTGTREFKVLKSVASNHRGSMINVEENSDFLNGFGFN", "length": 796, "header": "tr|A0AAA9S5Z1-1|A0AAA9S5Z1_BOVIN Isoform 1 of Protocadherin beta 11 OS=Bos taurus OX=9913 GN=PCDHB11 PE=4 SV=1 CANONICAL=A0AAA9S5Z1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1/entry#A0AAA9S5Z1-1", "sequence": { "sequence": "MELGKGNPQQIRQVLLFFVFLGGSLVCSETWRYSVAEETEIGSFIGNVVKDIGLGVEDLAARGARVIFDDYKPHLRLDLQTGNLLLNEQPDREALCDLTEPCILHFQVLLENPLQFFRAELWVEDINDHTPTFTNKHILLKISESTAPGTSFQMDSAQDLDVGKNGVQNYTLNPNLHFHLKLQDSEDGRKYPELLLDQPLDREKEPELRLTLTALDGGSPARSGTALVRVLVLDINDNAPQFERSVYEVPIPENSPLDFLVVRVSATDLDAGINGELSYSFSHVSRDIQKTFEIHPIFGEVRLKAFLDFELLQSYTINIQAIDGGGLSGKSVILVSVVDVNDNPPEVVVTSLTSPIPENSSPEMVVAVFSLRDQDSGDNGRMVCSIQDNLPFLLKPNFKNFYTLETESPLDRESKAEYIITITVTDMGTPRLKTEHNITVLVSDVNDNAPTFTQTSYTLWVRENNSPALHIGSVSATDTDAGANAQVTYSLLPPPDPLVPLASLVSINPDNGHLFALTSLDYEALRAFEFRVGATDRGSPALSSQALVRVLVADANDNAPFVLYPLQNASAPCTELVPRAAEPGYLVTKVVAVDGDAGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAPKQRLVVLVKDNGEPPLSASVTLHVLLVDGFSQPYLPAPEAEAAAAAPADPLTVYLVVALASVSSLFLFSVLVFVAVRLCRRAGATSAGRCPVLEGHFPGHLVDVSGTGTLSQSYQYEVCLTGGTGTREFKVLKSVASNHRGSMINVEENSDFLNGFGFN", "length": 796, "header": "tr|A0AAA9S5Z1-1|A0AAA9S5Z1_BOVIN Isoform 1 of Protocadherin beta 11 OS=Bos taurus OX=9913 GN=PCDHB11 PE=4 SV=1 CANONICAL=A0AAA9S5Z1-1" }, "locus": { "chromosome": "7", "start_pos": 52341357, "end_pos": 52338970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101657.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101657.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078727.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 568, "end_pos": 570, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z1" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 134, "end_pos": 242, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 }, { "start_pos": 359, "end_pos": 361 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 568, "end_pos": 570 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5Z6-1", "uniprot_ac": "A0AAA9S5Z6", "uniprot_id": "A0AAA9S5Z6_BOVIN", "mass": { "chemical_mass": 84883.0, "monoisotopic_mass": 84883.0 }, "refseq": {}, "gene_names": [ { "name": "DCLRE1C", "type": "recommended", "evidence": [ { "id": "A0AAA9S5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ] } ], "protein_names": [ { "name": "Protein artemis", "type": "recommended", "evidence": [ { "id": "A0AAA9S5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6/entry#names_and_taxonomy" } ] }, { "name": "DNA cross-link repair 1C protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCLRE1C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6", "locus": { "chromosome": "13", "start_pos": 29554305, "end_pos": 29588308, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010220", "url": "https://www.ensembl.org/id/ENSBTAG00000010220" } ] } } ], "crossref": [ { "id": "A0AAA9S5Z6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5Z6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16297", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16297", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23240:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23240:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RCK7", "url": "https://www.uniprot.org/uniprotkb/F6RCK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RCK7-1", "url": "https://www.uniprot.org/uniprotkb/F6RCK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPSLKRRLECSLKVCLYCSPVTKELLLTSPKYRFWEKRIVSIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAKGEAARMELLHSGGRVKDIQSVYLDTTFCNPKYYQIPSREECLRGIMELVRSWISRSPYHVVWLNCKAAYGYEYLFTNLSEEFGLQVHVDKLDMFRNMPDILHHLTTDRDTQIHACRHPKAEEYFQWSKLPCGITSKNRIPLHTISIKPSTMWFGERTRKTNIIMRTGESSYRACFSFHSSYSEVRGSHRLRTSAAFMASGGISFSTAQGGLWLFLKKCREDISVDEIKDFLSYICPVNVYPNVIPLGTTMDKVKEILKPLCRSSQSTEPKYKPLGKLKRARTMHLDSEEEDDDGLFDDLLPAPLRHKVPNQLTLHPEVFPTPAISQNQPEKRRESTGCFKAESMPTFLWANFIDCEESNSESEESEILGSAQGDTGPVFQPQQRADGEVPQWEVFFKRDAEGTDDCLENLPSSTEVGGSQSPKLFSDSDGESTHISSQASSQSTHISEQGSQGWDSQSDTVLLSSQDRNSGDVTSLNKGVYRPGIKENIPAPQPEQNVLCLKDTCSDFKSRDQDVNILPSAGETTTLSSGKQMLQEKRPLTLSSSADSQSSSDFEIPCTPEAELPKQEHLQYLYEKLATGESIVVEKRKGLLHSKATTKKSILSDTSQNHNR", "length": 753, "header": "tr|A0AAA9S5Z6-1|A0AAA9S5Z6_BOVIN Isoform 1 of Protein artemis OS=Bos taurus OX=9913 GN=DCLRE1C PE=3 SV=1 CANONICAL=A0AAA9S5Z6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6/entry#A0AAA9S5Z6-1", "sequence": { "sequence": "MSCFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPSLKRRLECSLKVCLYCSPVTKELLLTSPKYRFWEKRIVSIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAKGEAARMELLHSGGRVKDIQSVYLDTTFCNPKYYQIPSREECLRGIMELVRSWISRSPYHVVWLNCKAAYGYEYLFTNLSEEFGLQVHVDKLDMFRNMPDILHHLTTDRDTQIHACRHPKAEEYFQWSKLPCGITSKNRIPLHTISIKPSTMWFGERTRKTNIIMRTGESSYRACFSFHSSYSEVRGSHRLRTSAAFMASGGISFSTAQGGLWLFLKKCREDISVDEIKDFLSYICPVNVYPNVIPLGTTMDKVKEILKPLCRSSQSTEPKYKPLGKLKRARTMHLDSEEEDDDGLFDDLLPAPLRHKVPNQLTLHPEVFPTPAISQNQPEKRRESTGCFKAESMPTFLWANFIDCEESNSESEESEILGSAQGDTGPVFQPQQRADGEVPQWEVFFKRDAEGTDDCLENLPSSTEVGGSQSPKLFSDSDGESTHISSQASSQSTHISEQGSQGWDSQSDTVLLSSQDRNSGDVTSLNKGVYRPGIKENIPAPQPEQNVLCLKDTCSDFKSRDQDVNILPSAGETTTLSSGKQMLQEKRPLTLSSSADSQSSSDFEIPCTPEAELPKQEHLQYLYEKLATGESIVVEKRKGLLHSKATTKKSILSDTSQNHNR", "length": 753, "header": "tr|A0AAA9S5Z6-1|A0AAA9S5Z6_BOVIN Isoform 1 of Protein artemis OS=Bos taurus OX=9913 GN=DCLRE1C PE=3 SV=1 CANONICAL=A0AAA9S5Z6-1" }, "locus": { "chromosome": "13", "start_pos": 29588272, "end_pos": 29554373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126683.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126683.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078733.1" } ] } }, { "isoform_ac": "A0AAA9SEI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6/entry#A0AAA9SEI9-1", "sequence": { "sequence": "MSCFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPSLKRRLECRFLFQGNNGTVLYTGDFRLAKGEAARMELLHSGGRVKDIQSVYLDTTFCNPKYYQIPSREECLRGIMELVRSWISRSPYHVVWLNCKAAYGYEYLFTNLSEEFGLQVHVDKLDMFRNMPDILHHLTTDRDTQIHACRHPKAEEYFQWSKLPCGITSKNRIPLHTISIKPSTMWFGERTRKTNIIMRTGESSYRACFSFHSSYSEIKDFLSYICPVNVYPNVIPLGTTMDKVKEILKPLCRSSQSTEPKYKPLGKLKRARTMHLDSEEEDDDGLFDDLLPAPLRHKVPNQLTLHPEVFPTPAISQNQPEKRRESTGCFKAESMPTFLWANFIDCEESNSESEESEILGSAQGDTGPVFQPQQRADGEVPQWEVFFKRDAEGTDDCLENLPSSTEVGGSQSPKLFSDSDGESTHISSQASSQSTHISEQGSQGWDSQSDTVLLSSQDRNSGDVTSLNKGVYRPGIKENIPAPQPEQNVLCLKDTCSDFKSRDQDVNILPSAGETTTLSSGKQMLQEKRPLTLSSSADSQSSSDFEIPCTPEAELPKQEHLQYLYEKLATGESIVVEKRKGLLHSKATTKKSILSDTSQNHNR", "length": 643, "header": "tr|A0AAA9SEI9-1|A0AAA9SEI9_BOVIN Computationally mapped isoform of Protein artemis OS=Bos taurus OX=9913 GN=DCLRE1C PE=3 SV=1 CANONICAL=A0AAA9S5Z6-1" }, "locus": { "chromosome": "13", "start_pos": 29588272, "end_pos": 29554373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105546.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105546.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082019.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082019.1" } ] } }, { "isoform_ac": "F6RCK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6/entry#F6RCK7-1", "sequence": { "sequence": "MSCFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPSLKRRLECSLKVCLYCSPVTKELLLTSPKYRFWEKRIKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAKGEAARMELLHSGGRVKDIQSVYLDTTFCNPKYYQIPSREECLRGIMELVRSWISRSPYHVVWLNCKAAYGYEYLFTNLSEEFGLQVHVDKLDMFRNMPDILHHLTTDRDTQIHACRHPKAEEYFQWSKLPCGITSKNRIPLHTISIKPSTMWFGERTRKTNIIMRTGESSYRACFSFHSSYSEIKDFLSYICPVNVYPNVIPLGTTMDKVKEILKPLCRSSQSTEPKYKPLGKLKRARTMHLDSEEEDDDGLFDDLLPAPLRHKVPNQLTLHPEVFPTPAISQNQPEKRRESTGCFKAESMPTFLWANFIDCEESNSESEESEILGSAQGDTGPVFQPQQRADGEVPQWEVFFKRDAEGTDDCLENLPSSTEVGGSQSPKLFSDSDGESTHISSQASSQSTHISEQGSQGWDSQSDTVLLSSQDRNSGDVTSLNKGVYRPGIKENIPAPQPEQNVLCLKDTCSDFKSRDQDVNILPSAGETTTLSSGKQMLQEKRPLTLSSSADSQSSSDFEIPCTPEAELPKQEHLQYLYEKLATGESIVVEKRKGLLHSKATTKKSILSDTSQNHNR", "length": 690, "header": "tr|F6RCK7-1|F6RCK7_BOVIN Computationally mapped isoform of Protein artemis OS=Bos taurus OX=9913 GN=DCLRE1C PE=3 SV=1 CANONICAL=A0AAA9S5Z6-1" }, "locus": { "chromosome": "13", "start_pos": 29588272, "end_pos": 29554373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013484.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013484.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013484.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013484.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 462, "start_aa": "Thr", "end_pos": 462, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr462", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nonhomologous end joining complex", "id": "GO:0070419", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070419", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "single-stranded DNA endodeoxyribonuclease activity", "id": "GO:0000014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000014", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" }, { "name": "5'-3' exonuclease activity", "id": "GO:0008409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" }, { "name": "exonuclease activity", "id": "GO:0004527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Z6" }, { "id": "PF07522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA repair metallo-beta-lactamase", "eco_id": "ECO_0000259", "start_pos": 240, "end_pos": 326, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 462 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 218, "end_pos": 220 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S600-1", "uniprot_ac": "A0AAA9S600", "uniprot_id": "A0AAA9S600_BOVIN", "mass": { "chemical_mass": 143660.0, "monoisotopic_mass": 143660.0 }, "refseq": { "ac": "XP_024849845", "name": "interphotoreceptor matrix proteoglycan 2 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849845" }, "gene_names": [ { "name": "IMPG2", "type": "recommended", "evidence": [ { "id": "A0AAA9S600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ] }, { "name": "IMPG2", "type": "synonym", "evidence": [ { "id": "XP_024849845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849845" } ] } ], "protein_names": [ { "name": "Interphotoreceptor matrix proteoglycan 2", "type": "recommended", "evidence": [ { "id": "A0AAA9S600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600/entry#names_and_taxonomy" } ] }, { "name": "Sialoprotein associated with cones and rods proteoglycan", "type": "synonym", "evidence": [ { "id": "A0AAA9S600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600/entry#names_and_taxonomy" } ] }, { "name": "interphotoreceptor matrix proteoglycan 2 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024849845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849845" } ] } ], "function": [ { "annotation": "Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.", "evidence": [ { "database": "UniProtKB", "id": "E1BBU2", "url": "https://www.uniprot.org/uniprotkb/E1BBU2#function" }, { "database": "UniProtKB", "id": "ARBA00056016", "url": "https://www.uniprot.org/uniprotkb/ARBA00056016#function" }, { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IMPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600", "locus": { "chromosome": "1", "start_pos": 45742896, "end_pos": 45816852, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015662", "url": "https://www.ensembl.org/id/ENSBTAG00000015662" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015662", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015662", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517845", "url": "https://www.ncbi.nlm.nih.gov/gene/517845", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517845", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517845", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BBU2", "url": "https://www.orthodb.org/?gene=E1BBU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12199:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12199:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024849845", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849845", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S600-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBU2", "url": "https://www.uniprot.org/uniprotkb/E1BBU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBU2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDFFCNSLLLDISRLFSYRVWPLLLLLVLAQMIMFPHFGKISLCILIFVLIEGNLPSLTAQTYLSLEEIQEPKSTVSFLQTDSESTDSSLSAKKKQPLDSRETERHWLLRRKRSTLFPNGVKTCPDESVTEAVANHVKYFKVRVCQEAVWEAFRTFWDRLPGREEYHYWMNLCEDGITTIFEMGTHFSQSVEHRSLIMQKLTYAKETVSGSELSSPVPVGDMSTLGDAGLSVPYPGVTSYEGISESSLERPEDSISNEIENVVEESTKTAAEQVAEFSIHLLGEQYNEELQDPSSFHHQRLVEDFISEVENAFTGLPGYKDIRVLDFRSPKENGSGIDVHYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTAVYTISNFRDYIAETLHQNFLLGSSSLNPDPDSLQLINVRGVLLPQSEDQVWNTQSSSLQQALPSILDNTPQAEWPSADESTTSSISPLGFSSGLPSATGRELWSESPLGDLVSTPKLAFPSKVSLSSSPEVLDVSGLTLHSVTPAVLQTDLPVASEERTSGSHSLEDGLMKVEVSEDFLSINPLPSSPFTYPVPKETPPSMEDSGVSLPSSPYPVSSVTFDLLAKEVTTPFGMDSLASKVKDQLEVSSWMPDTTMEKEFMFESGLGSGSGQKIDLITWPWSETSLEKSTEPLSKSWLEVEDSLLLTEGIDVKPVIDDKIDSADQRAEHSEYGPFDGSTNFAEDEPLGGPTVSLFAETTTQSASPVLPKHTSEVPDIDYYSVTKSPPLLTFVAVSASIDKADQVEHFLKEDMEQTTESFNHEWFDSKISIEKSDVQPLRTTVPESDVFWARTSPLGKLSRDTLASTPQSTDKLWLKASMTQSTKLPSTISSTLLEDEVIMGVQDISLELDQIGTDYYQPELIPEESGMVGSYVEMSTNIHSTEMAVVAQPTRSDDLSHTQAVGAVVVFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFTRSVLPNVTNAVYVILEDFCTTAYQTMNLAIDKYSLDVESGDQANPCKFQACNEFSECLVNPWSGEAECRCYPGYLSVEDLPCQSLCDLQPNFCLNDGKCDIMPGHGAICRCRVGENWWYRGEHCEEFVSEPLVIGVTIASMIGLVLISSAVVFFIIKALQAQYVRRERERPSSRQRDGLSSVERAVKHNPVFESYEADLEQYEGPYPQRPFYSSTDREMIAGLSREEIRQMYENSDLSREEIQERMRILELYARDPEFAAFVREHQIREEL", "length": 1284, "header": "tr|A0AAA9S600-1|A0AAA9S600_BOVIN Isoform 1 of Interphotoreceptor matrix proteoglycan 2 OS=Bos taurus OX=9913 GN=IMPG2 PE=4 SV=1 CANONICAL=A0AAA9S600-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S600-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600/entry#A0AAA9S600-1", "sequence": { "sequence": "MLDFFCNSLLLDISRLFSYRVWPLLLLLVLAQMIMFPHFGKISLCILIFVLIEGNLPSLTAQTYLSLEEIQEPKSTVSFLQTDSESTDSSLSAKKKQPLDSRETERHWLLRRKRSTLFPNGVKTCPDESVTEAVANHVKYFKVRVCQEAVWEAFRTFWDRLPGREEYHYWMNLCEDGITTIFEMGTHFSQSVEHRSLIMQKLTYAKETVSGSELSSPVPVGDMSTLGDAGLSVPYPGVTSYEGISESSLERPEDSISNEIENVVEESTKTAAEQVAEFSIHLLGEQYNEELQDPSSFHHQRLVEDFISEVENAFTGLPGYKDIRVLDFRSPKENGSGIDVHYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTAVYTISNFRDYIAETLHQNFLLGSSSLNPDPDSLQLINVRGVLLPQSEDQVWNTQSSSLQQALPSILDNTPQAEWPSADESTTSSISPLGFSSGLPSATGRELWSESPLGDLVSTPKLAFPSKVSLSSSPEVLDVSGLTLHSVTPAVLQTDLPVASEERTSGSHSLEDGLMKVEVSEDFLSINPLPSSPFTYPVPKETPPSMEDSGVSLPSSPYPVSSVTFDLLAKEVTTPFGMDSLASKVKDQLEVSSWMPDTTMEKEFMFESGLGSGSGQKIDLITWPWSETSLEKSTEPLSKSWLEVEDSLLLTEGIDVKPVIDDKIDSADQRAEHSEYGPFDGSTNFAEDEPLGGPTVSLFAETTTQSASPVLPKHTSEVPDIDYYSVTKSPPLLTFVAVSASIDKADQVEHFLKEDMEQTTESFNHEWFDSKISIEKSDVQPLRTTVPESDVFWARTSPLGKLSRDTLASTPQSTDKLWLKASMTQSTKLPSTISSTLLEDEVIMGVQDISLELDQIGTDYYQPELIPEESGMVGSYVEMSTNIHSTEMAVVAQPTRSDDLSHTQAVGAVVVFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFTRSVLPNVTNAVYVILEDFCTTAYQTMNLAIDKYSLDVESGDQANPCKFQACNEFSECLVNPWSGEAECRCYPGYLSVEDLPCQSLCDLQPNFCLNDGKCDIMPGHGAICRCRVGENWWYRGEHCEEFVSEPLVIGVTIASMIGLVLISSAVVFFIIKALQAQYVRRERERPSSRQRDGLSSVERAVKHNPVFESYEADLEQYEGPYPQRPFYSSTDREMIAGLSREEIRQMYENSDLSREEIQERMRILELYARDPEFAAFVREHQIREEL", "length": 1284, "header": "tr|A0AAA9S600-1|A0AAA9S600_BOVIN Isoform 1 of Interphotoreceptor matrix proteoglycan 2 OS=Bos taurus OX=9913 GN=IMPG2 PE=4 SV=1 CANONICAL=A0AAA9S600-1" }, "locus": { "chromosome": "1", "start_pos": 45816653, "end_pos": 45743522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126328.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126328.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078739.1" } ] } }, { "isoform_ac": "E1BBU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600/entry#E1BBU2-1", "sequence": { "sequence": "MSVFVYFLSFCIFIHHHQFCLCFHSVAQTYLSLEEIQEPKSTVSFLQTDSESTDSSLSAKKKQPLDSRETERHWLLRRKRSTLFPNGVKTCPDESVTEAVANHVKYFKVRVCQEAVWEAFRTFWDRLPGREEYHYWMNLCEDGITTIFEMGTHFSQSVEHRSLIMQKLTYAKETVSGSELSSPVPVGDMSTLGDAGLSVPYPGVTSYEGISESSLERPEDSISNEIENVVEESTKTAAEQVAEFSIHLLGEQYNEELQDPSSFHHQRLVEDFISEVENAFTGLPGYKDIRVLDFRSPKENGSGIDVHYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTAVYTISNFRDYIAETLHQNFLLGSSSLNPDPDSLQLINVRGVLLPQSEDQVWNTQSSSLQQALPSILDNTPQAEWPSADESTTSSISPLGFSSGLPSATGRELWSESPLGDLVSTPKLAFPSKVSLSSSPEVLDVSGLTLHSVTPAVLQTDLPVASEERTSGSHSLEDGLMKVEVSEDFLSINPLPSSPFTYPVPKETPPSMEDSGVSLPSSPYPVSSVTFDLLAKEVTTPFGMDSLASKVKDQLEVSSWMPDTTMEKEFMFESGLGSGSGQKIDLITWPWSETSLEKSTEPLSKSWLEVEDSLLLTEGIDVKPVIDDKIDSADQRAEHSEYGPFDGSTNFAEDEPLGGPTVSLFAETTTQSASPVLPKHTSEVPDIDYYSVTKSPPLLTFVAVSASIDKADQVEHFLKEDMEQTTESFNHEWFDSKISIEKSDVQPLRTTVPESDVFWARTSPLGKLSRDTLASTPQSTDKLWLKASMTQSTKLPSTISSTLLEDEVIMGVQDISLELDQIGTDYYQPELIPEESGMVGSYVEMSTNIHSTEMAVVAQPTRSDDLSHTQAVGAVVVFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFTRSVLPNVTNAVYVILEDFCTTAYQTMNLAIDKYSLDVESGDQANPCKFQACNEFSECLVNPWSGEAECRCYPGYLSVEDLPCQSLCDLQPNFCLNDGKCDIMPGHGAICRCRVGENWWYRGEHCEEFVSEPLVIGVTIASMIGLVLISSAVVFFIIKALQAQYVRRERERPSSRQRDGLSSVERAVKHNPVFESYEADLEQYEGPYPQRPFYSSTDREMIAGLSREEIRQMYENSDLSREQGRALIKTHICN", "length": 1231, "header": "tr|E1BBU2-1|E1BBU2_BOVIN Computationally mapped isoform of Interphotoreceptor matrix proteoglycan 2 OS=Bos taurus OX=9913 GN=IMPG2 PE=4 SV=3 CANONICAL=A0AAA9S600-1" }, "locus": { "chromosome": "1", "start_pos": 45816098, "end_pos": 45743499, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020801.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020801.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020801.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020801.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 730, "start_aa": "Thr", "end_pos": 730, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr730", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517845", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517845", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "interphotoreceptor matrix", "id": "GO:0033165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "pmid": "" }, { "name": "gel phase of interstitial matrix", "id": "GO:0140150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140150", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "pmid": "" }, { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S600", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1001, "end_pos": 1003, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1019, "end_pos": 1021, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 987, "end_pos": 989, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 1096, "end_pos": 1138, "start_aa": "Gln", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S600" }, { "id": "PS50024", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEA", "eco_id": "ECO_0000259", "start_pos": 272, "end_pos": 386, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 730 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1001, "end_pos": 1003 }, { "start_pos": 1019, "end_pos": 1021 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 987, "end_pos": 989 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S609-1", "uniprot_ac": "A0AAA9S609", "uniprot_id": "A0AAA9S609_BOVIN", "mass": { "chemical_mass": 36082.0, "monoisotopic_mass": 36082.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" }, { "database": "UniProtKB", "id": "F1MDQ7", "url": "https://www.uniprot.org/uniprotkb/F1MDQ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609", "locus": {} } ], "crossref": [ { "id": "A0AAA9S609", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S609", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032428", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032428", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15237", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15237", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S609-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDQ7", "url": "https://www.uniprot.org/uniprotkb/F1MDQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDQ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MDQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRPQVVDTRNGSTVTEFILVGFEQSSPSTRTLLFALFLTLYSLAMAMNGLIIFITWTDPRLNSPMYFFLGHLSLLDVCFITTTIPQMLIHLVIKNHTLTFASCLTQMYLVFGVGVAECILLAFMAYDRYVAICHPLSYAQIMSRQVCVRLVSTAWFFGLINGILLDYMTFRGPFCRDNHIENFFCEAPIVIALSCGDPQFSLRVIFADAIVVLLSPVVLIVISYARILASILGRNSSSGRGKTFSTCASHLTVVIFFYTSAMFSYMNPRSTHGPDKDKPFSLLYTIITPMCNPVIYSFRNKEMKGAMARALGRSSLSQAESV", "length": 323, "header": "tr|A0AAA9S609-1|A0AAA9S609_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S609-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S609-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609/entry#A0AAA9S609-1", "sequence": { "sequence": "MSRPQVVDTRNGSTVTEFILVGFEQSSPSTRTLLFALFLTLYSLAMAMNGLIIFITWTDPRLNSPMYFFLGHLSLLDVCFITTTIPQMLIHLVIKNHTLTFASCLTQMYLVFGVGVAECILLAFMAYDRYVAICHPLSYAQIMSRQVCVRLVSTAWFFGLINGILLDYMTFRGPFCRDNHIENFFCEAPIVIALSCGDPQFSLRVIFADAIVVLLSPVVLIVISYARILASILGRNSSSGRGKTFSTCASHLTVVIFFYTSAMFSYMNPRSTHGPDKDKPFSLLYTIITPMCNPVIYSFRNKEMKGAMARALGRSSLSQAESV", "length": 323, "header": "tr|A0AAA9S609-1|A0AAA9S609_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S609-1" }, "locus": { "chromosome": "5", "start_pos": 32074017, "end_pos": 32067561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124163.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124163.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078744.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078744.1" } ] } }, { "isoform_ac": "F1MDQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609/entry#F1MDQ7-1", "sequence": { "sequence": "MRPQVVDTRNGSTVTEFILVGFEQSSPSTRTLLFALFLTLYSLAMAMNGLIIFITWTDPRLNSPMYFFLGHLSLLDVCFITTTIPQMLIHLVIKNHTLTFASCLTQMYLVFGVGVAECILLAFMAYDRYVAICHPLSYAQIMSRQVCVRLVSTAWFFGLINGILLDYMTFRGPFCRDNHIENFFCEAPIVIALSCGDPQFSLRVIFADAIVVLLSPVVLIVISYARILASILGRNSSSGRGKTFSTCASHLTVVIFFYTSAMFSYMNPRSTHGPDKDKPFSLLYTIITPMCNPVIYSFRNKEMKGAMARALGRSSLSQAESV", "length": 322, "header": "tr|F1MDQ7-1|F1MDQ7_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=A0AAA9S609-1" }, "locus": { "chromosome": "5", "start_pos": 32074017, "end_pos": 32067561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003874.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003874.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003874.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003874.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S609", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S609" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 297, "start_aa": "Met", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S621-1", "uniprot_ac": "A0AAA9S621", "uniprot_id": "A0AAA9S621_BOVIN", "mass": { "chemical_mass": 37724.0, "monoisotopic_mass": 37724.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Cytochrome c oxidase assembly factor COX18", "type": "synonym", "evidence": [ { "id": "A0AAA9S621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S621", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621", "locus": {} } ], "crossref": [ { "id": "A0AAA9S621", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S621", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WQRKRIV", "url": "https://omabrowser.org/oma/group/WQRKRIV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12428:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S621", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S621-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLCRLSVRWLRPRPALQVRVLDPLLARAPAGGAKSSALPVWAVASVSAVGLSGAGGWYEALATSAPVQGAEDVLLFAHTASGLPWWGSILLTTVVLRGAVTLPLAAYQHYILAKVENLQPEIKNIARHLNQEVAVRAHQLGWSKRVARLTYLKTMRRLVSELYVRDNCHPFKATVLVWIQLPMWIFMSVALRNFSTGAAHSEAGFSVQEQLTAGGVLWFHDLTALDSTWILPVSVGVINLLIVEIFALQKLGKSRFQTYITHFVRAVSVLMIPVAATVPSSIVLYWLCSSFMGLSQNLLLRSPGFRQLCRIPLTKLDSDTPYKDLLAAFHSKFISRKSRTF", "length": 341, "header": "tr|A0AAA9S621-1|A0AAA9S621_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor COX18 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S621-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S621-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621/entry#A0AAA9S621-1", "sequence": { "sequence": "MLCRLSVRWLRPRPALQVRVLDPLLARAPAGGAKSSALPVWAVASVSAVGLSGAGGWYEALATSAPVQGAEDVLLFAHTASGLPWWGSILLTTVVLRGAVTLPLAAYQHYILAKVENLQPEIKNIARHLNQEVAVRAHQLGWSKRVARLTYLKTMRRLVSELYVRDNCHPFKATVLVWIQLPMWIFMSVALRNFSTGAAHSEAGFSVQEQLTAGGVLWFHDLTALDSTWILPVSVGVINLLIVEIFALQKLGKSRFQTYITHFVRAVSVLMIPVAATVPSSIVLYWLCSSFMGLSQNLLLRSPGFRQLCRIPLTKLDSDTPYKDLLAAFHSKFISRKSRTF", "length": 341, "header": "tr|A0AAA9S621-1|A0AAA9S621_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor COX18 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S621-1" }, "locus": { "chromosome": "6", "start_pos": 88184784, "end_pos": 88174351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096564.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096564.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077613.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077613.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XPA3-1", "protein_name": "Cytochrome c oxidase assembly factor COX18", "gene_name": "COX18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWRLARSLRQSGSSWQLGGAAVARLTVAAGSPAPSGSPGGWYEWLAQSTPVHWAEDGLVALQAAAGLPWWAAIVCGGALLRSAVTLPLAAHQGRLLAKLENLQPEIKKLAEQLRYEVSVRGKQMGWSEKVARFHFKKKLRRIITELYIRDNCHPFKATLLVWVQIPMWVCVSLALRNCSVGALDSEVQEQFSTGGTLWFTDLTAPDSTWIMPVSLGLLNLLIVEIFASQKLEASRFQKLATNFFRVLSVVMIPVAATVPSSMALYWLSSSFMGLSHNLLLRSPTVRRLCCIPRTKSDSDTPYRDIVSALTTKYSFKK", "length": 317 }, "evidence": [ { "id": "A0AAA9S621", "url": "https://omabrowser.org/oma/group/A0AAA9S621/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A568-1", "protein_name": "Cytochrome c oxidase assembly factor COX18", "gene_name": "Cox18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLCGSCAGLLRSLRTLQLRAPGSLPAWSSARLPTLPVWAAASVSAASPGGWYEALAASAPVHAAEEMLLSAQETTGLPWWGNILLSTVVLRGAVTLPLAAYQHYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNIRRLVSELYVRDNCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDAGISVQDQLAAGGTLWFPDLTAVDSTWILPVSVGVVNLLIVEIFALQKIGKSRFQMYVTNFVRAVSVLMVPVAATVPSALVLYWLCSSLMGLSQNLLLRSPGFRQLCRIPPSRSDSETPYRDLSAAFCAKFLSRKR", "length": 332 }, "evidence": [ { "id": "A0AAA9S621", "url": "https://omabrowser.org/oma/group/A0AAA9S621/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53239-1", "protein_name": "Cytochrome c oxidase assembly protein COX18, mitochondrial", "gene_name": "COX18", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLKRLANRQNGFASFSCSSVGLRYGRTNPSTKRSFSLFQSVADTFLTVHEASHIPWIVLVPLTTMTLRTLVTLPFSIWQRRRILKQQELRKLVQPITPIIKLRLAAVTNKKSRNAARISSNGSFMPLQLQNAGVLTPEQITLLAVKETRKRQKKLFKKYNVPLWKNALLPMVQIPLWVTVSMGIRTLTETQLIESFYPSWFSALGFSSFDLSSPLVAMPLLAPILVGTLAVLNVELNGRLMFSSSLSSQGIKTISRNSTRVQEAMTSILNVSRLGCVVMLAMSSQAPFLLSLYWISSQLFSLVQNIILNWIYPYQR", "length": 316 }, "evidence": [ { "id": "A0AAA9S621", "url": "https://omabrowser.org/oma/group/A0AAA9S621/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8VC74-1", "protein_name": "Cytochrome c oxidase assembly protein COX18, mitochondrial", "gene_name": "Cox18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLCRSCAGWLRSLPTLRLPAPGSPPAWSSARLPALPVWAAASVSAASPGGWYEALAASAPVRTAEEVLLGAQEATGLPWWSNIILSTVALRGAVTLPLAAYQHYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNMRRLISELYVRDNCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDGISVQEQLAAGGTLWFPDLTAVDSTWILPVSVGVVNLLIVEIFALQKIGTSRFQMYVTNFVRAVSVLMIPVAATVPSALVLYWLCSSLMGLAQNLLLRSPGFRQLCRIPPSKSDSETPYRDLSAAFCAKFLSRKR", "length": 331 }, "evidence": [ { "id": "A0AAA9S621", "url": "https://omabrowser.org/oma/group/A0AAA9S621/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S621", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein insertion into membrane", "id": "GO:0051205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051205", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S621", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S621", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S621" }, { "id": "PF02096", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02096" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Membrane insertase YidC/Oxa/ALB C-terminal", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 301, "start_aa": "His", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S628-1", "uniprot_ac": "A0AAA9S628", "uniprot_id": "A0AAA9S628_BOVIN", "mass": { "chemical_mass": 107494.0, "monoisotopic_mass": 107494.0 }, "refseq": {}, "gene_names": [ { "name": "CC2D1A", "type": "recommended", "evidence": [ { "id": "A0AAA9S628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ] } ], "protein_names": [ { "name": "Coiled-coil and C2 domain-containing protein 1A", "type": "recommended", "evidence": [ { "id": "A0AAA9S628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628/entry#names_and_taxonomy" } ] }, { "name": "Five prime repressor element under dual repression-binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CC2D1A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628", "locus": { "chromosome": "7", "start_pos": 11766152, "end_pos": 11784471, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006068", "url": "https://www.ensembl.org/id/ENSBTAG00000006068" } ] } } ], "crossref": [ { "id": "A0AAA9S628", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S628", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08690", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08690", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13076", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13076", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13076:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13076:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21528", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21528", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S628-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q9I3", "url": "https://www.uniprot.org/uniprotkb/F6Q9I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q9I3-1", "url": "https://www.uniprot.org/uniprotkb/F6Q9I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHKKKGPPGPPGRGAATARQLGLLVDLSPDGLMIPEDGVNDEELEAEFLALVGGQPQALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEEDVEADDDLLAELNEVLGEEQKASESHPPVAQPKATTPSPGLEATLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASVRKGKAIDEGDIPPPVAVGKGPVATPSHTPAPTQPAPLNPLAPDPRVIVESPPSAAPSSSLASAKPQLPPGKEILTHATARMNLEDIMLREISQSQKEKYCPCSPGPLAQLQSRQREYKLAALHAKQQGDTAAAAKHFRVAKSFDAVLEALSRGEPVDLSRLPPPPDQLPQGPPSPPVQPPTPAVVPSTPEAPPPPKTLLEALEQRMERYHVAAAQAKTKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATEPTQQSLVGVLETAMKLANQDEGPEDEEDEEPKKLSSPAAPTAQPKAPPSKAPPSGSAPIAKAAPKGTSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGPGLSQESARRYGELTKLIRQQHEMCLNHSNQFTQLGNIAETSKFEKLAEDCKRSMEILKQAFARGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGISLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALETACEVREVLEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVIDPVPASVPTQVVGPKGKAPPIPAPTREPGNRSARPLHSLSVLAFDQERLERKILGLRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGPGMRREYMAQLERQLQFYTEAARRLGNDGSREAAKEALYRRNLVESELQRLRR", "length": 981, "header": "tr|A0AAA9S628-1|A0AAA9S628_BOVIN Isoform 1 of Coiled-coil and C2 domain-containing protein 1A OS=Bos taurus OX=9913 GN=CC2D1A PE=3 SV=1 CANONICAL=A0AAA9S628-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S628-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628/entry#A0AAA9S628-1", "sequence": { "sequence": "MHKKKGPPGPPGRGAATARQLGLLVDLSPDGLMIPEDGVNDEELEAEFLALVGGQPQALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEEDVEADDDLLAELNEVLGEEQKASESHPPVAQPKATTPSPGLEATLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASVRKGKAIDEGDIPPPVAVGKGPVATPSHTPAPTQPAPLNPLAPDPRVIVESPPSAAPSSSLASAKPQLPPGKEILTHATARMNLEDIMLREISQSQKEKYCPCSPGPLAQLQSRQREYKLAALHAKQQGDTAAAAKHFRVAKSFDAVLEALSRGEPVDLSRLPPPPDQLPQGPPSPPVQPPTPAVVPSTPEAPPPPKTLLEALEQRMERYHVAAAQAKTKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATEPTQQSLVGVLETAMKLANQDEGPEDEEDEEPKKLSSPAAPTAQPKAPPSKAPPSGSAPIAKAAPKGTSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGPGLSQESARRYGELTKLIRQQHEMCLNHSNQFTQLGNIAETSKFEKLAEDCKRSMEILKQAFARGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGISLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALETACEVREVLEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVIDPVPASVPTQVVGPKGKAPPIPAPTREPGNRSARPLHSLSVLAFDQERLERKILGLRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGPGMRREYMAQLERQLQFYTEAARRLGNDGSREAAKEALYRRNLVESELQRLRR", "length": 981, "header": "tr|A0AAA9S628-1|A0AAA9S628_BOVIN Isoform 1 of Coiled-coil and C2 domain-containing protein 1A OS=Bos taurus OX=9913 GN=CC2D1A PE=3 SV=1 CANONICAL=A0AAA9S628-1" }, "locus": { "chromosome": "7", "start_pos": 11784258, "end_pos": 11766648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089525.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089525.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078764.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078764.1" } ] } }, { "isoform_ac": "F6Q9I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628/entry#F6Q9I3-1", "sequence": { "sequence": "MHKKKGPPGPPGRGAATARQLGLLVDLSPDGLMIPEDGVNDEELEAEFLALVGGQPQALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEEDVEADDDLLAELNEVLGEEQKASESHPPVAQPKATTPSPGLEATLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASVRKGKAIDEGDIPPPVAVGKGPVATPSHTPAPTQPAPLNPLAPDPRVIVESPPSAAPSSSLASAKPQLPPGPCSPGPLAQLQSRQREYKLAALHAKQQGDTAAAAKHFRVAKSFDAVLEALSRGEPVDLSRLPPPPDQLPQGPPSPPVQPPTPAVVPSTPEAPPPPKTLLEALEQRMERYHVAAAQAKTKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATEPTQQSLVGVLETAMKLANQDEGPEDEEDEEPKKLSSPAAPTAQPKAPPSKAPPSGSAPIAKAAPKGTSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGPGLSQESARRYGELTKLIRQQHEMCLNHSNQFTQLGNIAETSKFEKLAEDCKRSMEILKQAFARGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGISLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALETACEVREVLEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVIDPVPASVPTFCSLKQVVGPKGKAPPIPAPTREPGNRSARPLHSLSVLAFDQERLERKILGLRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGPGMRREYMAQLERQLQFYTEAARRLGNDGSREAAKEALYRRNLVESELQRLRR", "length": 956, "header": "tr|F6Q9I3-1|F6Q9I3_BOVIN Computationally mapped isoform of Coiled-coil and C2 domain-containing protein 1A OS=Bos taurus OX=9913 GN=CC2D1A PE=3 SV=1 CANONICAL=A0AAA9S628-1" }, "locus": { "chromosome": "7", "start_pos": 11784258, "end_pos": 11766648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007973.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007973.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007973.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007973.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 204, "start_aa": "Thr", "end_pos": 204, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr204", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 212, "start_aa": "Thr", "end_pos": 212, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr212", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 361, "start_aa": "Thr", "end_pos": 361, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr361", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "negative regulation of snRNA transcription by RNA polymerase II", "id": "GO:1905381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905381", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S628", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 869, "end_pos": 871, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S628" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 667, "end_pos": 801, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 204, 212, 361 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 622, "end_pos": 624 }, { "start_pos": 749, "end_pos": 751 }, { "start_pos": 869, "end_pos": 871 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S660-1", "uniprot_ac": "A0AAA9S660", "uniprot_id": "A0AAA9S660_BOVIN", "mass": { "chemical_mass": 104097.0, "monoisotopic_mass": 104097.0 }, "refseq": {}, "gene_names": [ { "name": "ICAM5", "type": "recommended", "evidence": [ { "id": "A0AAA9S660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ] } ], "protein_names": [ { "name": "Intercellular adhesion molecule 5", "type": "recommended", "evidence": [ { "id": "A0AAA9S660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660/entry#names_and_taxonomy" } ] }, { "name": "Telencephalin", "type": "synonym", "evidence": [ { "id": "A0AAA9S660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion. Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660#function" }, { "database": "UniProtKB", "id": "ARBA00094440", "url": "https://www.uniprot.org/uniprotkb/ARBA00094440#function" }, { "database": "UniProtKB", "id": "E1BLR0", "url": "https://www.uniprot.org/uniprotkb/E1BLR0#function" }, { "database": "UniProtKB", "id": "A0AAA9TZZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZZ6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ICAM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660", "locus": { "chromosome": "7", "start_pos": 14834229, "end_pos": 14825140, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010316", "url": "https://www.ensembl.org/id/ENSBTAG00000010316" } ] } } ], "crossref": [ { "id": "A0AAA9S660", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S660", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05755", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05755", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BLR0", "url": "https://www.orthodb.org/?gene=E1BLR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13771:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13771:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S660-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLR0", "url": "https://www.uniprot.org/uniprotkb/E1BLR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLR0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSDYTLRCHVTHVFPVGFFVVTLRRGGRVIYSESLERFTGLDLANVTLTYLLPSRPGDFGQPFTCHARLNLDGLVVLSSSAPVTLPVPAVTQEPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQKGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPAWQPVGENFTLSCRVPGAGPRGSLTLTLLRGTQELIRRSFAGESPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFTLPPEPPRLTAPRLLEVGSEGPVSCVIDGLFPVSEAGVYLALGDQRLSPDVTLEGDALMATTTATASAEQEGARQLVCNVTLGGESRETRENVTVYSFPEPHLTLSEPNAPEGTIVTVTCAAETQALVTLEGIPAAAPGQPAQLQLNATEYDDRRGFFCDATLEVDGETLSKNESVELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCDARGNPQPSVHCARPDGAAVLALGLLGPVTRALAGTYRCTATNDQGQAVKDVTLTVEYAPALDSVGCPERITWLEGTEVSLSCVALGVPPPNVSCVRFGGAEVIEGLMRVAREHAGTYRCEATNARGSAAKNVAVTVEYGPRFEEVSCPSNWTWVEGSGRLFSCEVAGKPQPSVECVGSGGTSEGVLLPLAPPDPGSRAPRIPSDLAPGTYICNATNRHGSMVKMVTVSAESPPQMDESTCPSHQSWLEGAEAAALACSARGRPSPQVSCSREGAPRPQRLRVSREDAGTYRCLATNAHGTDARIITVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHTRRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGAGAGRDAGAEGGSEAAGTSEVPAGGEVFAIQLPSA", "length": 984, "header": "tr|A0AAA9S660-1|A0AAA9S660_BOVIN Isoform 1 of Intercellular adhesion molecule 5 OS=Bos taurus OX=9913 GN=ICAM5 PE=3 SV=1 CANONICAL=A0AAA9S660-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S660-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660/entry#A0AAA9S660-1", "sequence": { "sequence": "MGSDYTLRCHVTHVFPVGFFVVTLRRGGRVIYSESLERFTGLDLANVTLTYLLPSRPGDFGQPFTCHARLNLDGLVVLSSSAPVTLPVPAVTQEPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQKGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPAWQPVGENFTLSCRVPGAGPRGSLTLTLLRGTQELIRRSFAGESPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFTLPPEPPRLTAPRLLEVGSEGPVSCVIDGLFPVSEAGVYLALGDQRLSPDVTLEGDALMATTTATASAEQEGARQLVCNVTLGGESRETRENVTVYSFPEPHLTLSEPNAPEGTIVTVTCAAETQALVTLEGIPAAAPGQPAQLQLNATEYDDRRGFFCDATLEVDGETLSKNESVELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCDARGNPQPSVHCARPDGAAVLALGLLGPVTRALAGTYRCTATNDQGQAVKDVTLTVEYAPALDSVGCPERITWLEGTEVSLSCVALGVPPPNVSCVRFGGAEVIEGLMRVAREHAGTYRCEATNARGSAAKNVAVTVEYGPRFEEVSCPSNWTWVEGSGRLFSCEVAGKPQPSVECVGSGGTSEGVLLPLAPPDPGSRAPRIPSDLAPGTYICNATNRHGSMVKMVTVSAESPPQMDESTCPSHQSWLEGAEAAALACSARGRPSPQVSCSREGAPRPQRLRVSREDAGTYRCLATNAHGTDARIITVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHTRRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGAGAGRDAGAEGGSEAAGTSEVPAGGEVFAIQLPSA", "length": 984, "header": "tr|A0AAA9S660-1|A0AAA9S660_BOVIN Isoform 1 of Intercellular adhesion molecule 5 OS=Bos taurus OX=9913 GN=ICAM5 PE=3 SV=1 CANONICAL=A0AAA9S660-1" }, "locus": { "chromosome": "7", "start_pos": 14834079, "end_pos": 14825339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116060.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116060.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081446.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081446.1" } ] } }, { "isoform_ac": "A0AAA9TZZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660/entry#A0AAA9TZZ6-1", "sequence": { "sequence": "MPGPSPGLHRALLGLWAALGLGLLSLSAVTQEPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQKGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPAWQPVGENFTLSCRVPGAGPRGSLTLTLLRGTQELIRRSFAGESPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFTLPPEPPRLTAPRLLEVGSEGPVSCVIDGLFPVSEAGVYLALGDQRLSPDVTLEGDALMATTTATASAEQEGARQLVCNVTLGGESRETRENVTVYRVWGVEFELSLGKMGVSEPALYALFGCRAAAPGQPAQLQLNATEYDDRRGFFCDATLEVDGETLSKNESVELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCDARGNPQPSVHCARPDGAAVLALGLLGPVTRALAGTYRCTATNDQGQAVKDVTLTVEYAPALDSVGCPERITWLEGTEVSLSCVALGVPPPNVSCVRFGGAEVIEGLMRVAREHAGTYRCEATNARGSAAKNVAVTVEYGPRFEEVSCPSNWTWVEGSGRLFSCEVAGKPQPSVECVGSGGTSEGVLLPLAPPDPGSRAPRIPSDLAPGTYICNATNRHGSMVKMVTVSAESPPQMDESTCPSHQSWLEGAEAAALACSARGRPSPQVSCSREGAPRPQRLRVSREDAGTYRCLATNAHGTDARIITVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHTRRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGAGAGRDAGAEGGSEAAGTSEVPAGGEVFAIQLPSA", "length": 912, "header": "tr|A0AAA9TZZ6-1|A0AAA9TZZ6_BOVIN Computationally mapped isoform of Intercellular adhesion molecule 5 OS=Bos taurus OX=9913 GN=ICAM5 PE=3 SV=1 CANONICAL=A0AAA9S660-1" }, "locus": { "chromosome": "7", "start_pos": 14834079, "end_pos": 14827512, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095334.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095334.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102346.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102346.1" } ] } }, { "isoform_ac": "E1BLR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660/entry#E1BLR0-1", "sequence": { "sequence": "MPGPSPGLHRALLGLWAALGLGLLSLSAVTQEPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQKGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPAWQPVGENFTLSCRVPGAGPRGSLTLTLLRGTQELIRRSFAGESPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFTLPPEPPRLTAPRLLEVGSEGPVSCVIDGLFPVSEAGVYLALGDQRLSPDVTLEGDALMATTTATASAEQEGARQLVCNVTLGGESRETRENVTVYSFPEPHLTLSEPNAPEGTIVTVTCAAETQALVTLEGIPAAAPGQPAQLQLNATEYDDRRGFFCDATLEVDGETLSKNESVELRVLCSCIYMPLPSDAPRLDDSDCPRSWTWPEGPEQTLRCDARGNPQPSVHCARPDGAAVLALGLLGPVTRALAGTYRCTATNDQGQAVKDVTLTVEYAPALDSVGCPERITWLEGTEVSLSCVALGVPPPNVSCVRFGGAEVIEGLMRVAREHAGTYRCEATNARGSAAKNVAVTVEYGPRFEEVSCPSNWTWVEGSGRLFSCEVAGKPQPSVECVGSGGTSEGVLLPLAPPDPGSRAPRIPSDLAPGTYICNATNRHGSMVKMVTVSAESPPQMDESTCPSHQSWLEGAEAAALACSARGRPSPQVSCSREGAPRPQRLRVSREDAGTYRCLATNAHGTDARIITVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHTRRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGAGAGRDAGAEGGSEAAGTSEVPAGGEVFAIQLPSA", "length": 932, "header": "tr|E1BLR0-1|E1BLR0_BOVIN Computationally mapped isoform of Intercellular adhesion molecule 5 OS=Bos taurus OX=9913 GN=ICAM5 PE=3 SV=3 CANONICAL=A0AAA9S660-1" }, "locus": { "chromosome": "7", "start_pos": 14834079, "end_pos": 14827512, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036155.7", "url": "https://www.ensembl.org/id/ENSBTAT00000036155.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036018.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036018.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-198933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "uropod membrane", "id": "GO:0031259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "dendritic spine membrane", "id": "GO:0032591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "cell-cell adhesion mediated by integrin", "id": "GO:0033631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "regulation of synapse assembly", "id": "GO:0051963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051963", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S660", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 825, "end_pos": 827, "annotation": "n_glycosylation_sequon" }, { "start_pos": 856, "end_pos": 858, "annotation": "n_glycosylation_sequon" }, { "start_pos": 857, "end_pos": 859, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S660" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 470, "end_pos": 548, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 136, "end_pos": 138 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 365, "end_pos": 367 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 585, "end_pos": 587 }, { "start_pos": 644, "end_pos": 646 }, { "start_pos": 707, "end_pos": 709 }, { "start_pos": 825, "end_pos": 827 }, { "start_pos": 856, "end_pos": 858 }, { "start_pos": 857, "end_pos": 859 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S999-1", "uniprot_ac": "A0AAA9S999", "uniprot_id": "A0AAA9S999_BOVIN", "mass": { "chemical_mass": 25169.0, "monoisotopic_mass": 25169.0 }, "refseq": {}, "gene_names": [ { "name": "MPHOSPH6", "type": "recommended", "evidence": [ { "id": "A0AAA9S999", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999" } ] } ], "protein_names": [ { "name": "M-phase phosphoprotein 6", "type": "synonym", "evidence": [ { "id": "A0AAA9S999", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S999", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPHOSPH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999", "locus": { "chromosome": "18", "start_pos": 8717274, "end_pos": 8729352, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009746", "url": "https://www.ensembl.org/id/ENSBTAG00000009746" } ] } } ], "crossref": [ { "id": "A0AAA9S999", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S999", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019324", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13582:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13582:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S671", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S671", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S671-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S671-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S999", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S999-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPEATSKKRGPPRSARNRGEADGGGRTHATYDGADAHAETRMRGGSSCRPRRPVGVSMAAERKTKLSKNLLRMKFMQRGLDSETKKQLEEEEKKIISEEHWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNTKNKAEEVEEQTVELDVSDEEMARRYETLVGTIGKKFAKKRDRAIYEEDENGDIKPVKAKKMFLKPQD", "length": 218, "header": "tr|A0AAA9S999-1|A0AAA9S999_BOVIN Isoform 1 of M-phase phosphoprotein 6 OS=Bos taurus OX=9913 GN=MPHOSPH6 PE=4 SV=1 CANONICAL=A0AAA9S999-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S671-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999/entry#A0AAA9S671-1", "sequence": { "sequence": "MDRFMQRGLDSETKKQLEEEEKKIISEEHWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNTKNKAEEVEEQTVELDVSDEEMARRYETLVGTIGKKFAKKRDRAIYEEDENGDIKPVKAKKMFLKPQD", "length": 146, "header": "tr|A0AAA9S671-1|A0AAA9S999_BOVIN Computationally mapped isoform of M-phase phosphoprotein 6 OS=Bos taurus OX=9913 GN=MPHOSPH6 PE=4 SV=1 CANONICAL=A0AAA9S999-1" }, "locus": { "chromosome": "18", "start_pos": 8727606, "end_pos": 8717840, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127908.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127908.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077676.1" } ] } }, { "isoform_ac": "A0AAA9S999-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999/entry#A0AAA9S999-1", "sequence": { "sequence": "MFPEATSKKRGPPRSARNRGEADGGGRTHATYDGADAHAETRMRGGSSCRPRRPVGVSMAAERKTKLSKNLLRMKFMQRGLDSETKKQLEEEEKKIISEEHWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNTKNKAEEVEEQTVELDVSDEEMARRYETLVGTIGKKFAKKRDRAIYEEDENGDIKPVKAKKMFLKPQD", "length": 218, "header": "tr|A0AAA9S999-1|A0AAA9S999_BOVIN Isoform 1 of M-phase phosphoprotein 6 OS=Bos taurus OX=9913 GN=MPHOSPH6 PE=4 SV=1 CANONICAL=A0AAA9S999-1" }, "locus": { "chromosome": "18", "start_pos": 8729153, "end_pos": 8717840, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099404.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099404.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080505.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080505.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S999", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999" } ], "pmid": "" }, { "name": "nuclear exosome (RNase complex)", "id": "GO:0000176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S999", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "maturation of 5.8S rRNA", "id": "GO:0000460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000460", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S999", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S999" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S678-1", "uniprot_ac": "A0AAA9S678", "uniprot_id": "A0AAA9S678_BOVIN", "mass": { "chemical_mass": 31497.0, "monoisotopic_mass": 31497.0 }, "refseq": { "ac": "XP_003587247", "name": "chymotrypsinogen A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587247" }, "gene_names": [ { "name": "LOC100848132", "type": "recommended", "evidence": [ { "id": "A0AAA9S678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" } ] }, { "name": "LOC100848132", "type": "synonym", "evidence": [ { "id": "XP_003587247", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587247" } ] } ], "protein_names": [ { "name": "chymotrypsin", "type": "recommended", "evidence": [ { "id": "A0AAA9S678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.1", "type": "synonym", "evidence": [ { "id": "A0AAA9S678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678/entry#names_and_taxonomy" } ] }, { "name": "chymotrypsinogen A", "type": "synonym", "evidence": [ { "id": "XP_003587247", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587247" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S678", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100848132", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678", "locus": {} } ], "crossref": [ { "id": "A0AAA9S678", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S678", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011995", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011995", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100848132", "url": "https://www.ncbi.nlm.nih.gov/gene/100848132", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848132", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848132", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "G1K1L9", "url": "https://www.orthodb.org/?gene=G1K1L9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24250", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24250", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24250:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24250:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587247", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587247", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWD8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWD8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S678", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S678-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G1K1L9", "url": "https://www.uniprot.org/uniprotkb/G1K1L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G1K1L9-1", "url": "https://www.uniprot.org/uniprotkb/G1K1L9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRKGIITSRSSDNSLVHRDIIGSPAAGTPHLSEGSTMNFLWLLSYCALLGTAFGCGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN", "length": 300, "header": "tr|A0AAA9S678-1|A0AAA9S678_BOVIN Isoform 1 of chymotrypsin OS=Bos taurus OX=9913 GN=LOC100848132 PE=4 SV=1 CANONICAL=A0AAA9S678-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678/entry#A0A3Q1LWD8-1", "sequence": { "sequence": "MGKQTRSCGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN", "length": 252, "header": "tr|A0A3Q1LWD8-1|A0A3Q1LWD8_BOVIN Computationally mapped isoform of chymotrypsin OS=Bos taurus OX=9913 GN=LOC100848132 PE=4 SV=3 CANONICAL=A0AAA9S678-1" }, "locus": { "chromosome": "18", "start_pos": 2567838, "end_pos": 2565202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076474.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076474.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065010.3", "url": "https://www.ensembl.org/id/ENSBTAP00000065010.3" } ] } }, { "isoform_ac": "A0AAA9S678-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678/entry#A0AAA9S678-1", "sequence": { "sequence": "MPRKGIITSRSSDNSLVHRDIIGSPAAGTPHLSEGSTMNFLWLLSYCALLGTAFGCGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN", "length": 300, "header": "tr|A0AAA9S678-1|A0AAA9S678_BOVIN Isoform 1 of chymotrypsin OS=Bos taurus OX=9913 GN=LOC100848132 PE=4 SV=1 CANONICAL=A0AAA9S678-1" }, "locus": { "chromosome": "18", "start_pos": 2567838, "end_pos": 2564500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100697.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100697.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077681.1" } ] } }, { "isoform_ac": "G1K1L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678/entry#G1K1L9-1", "sequence": { "sequence": "MCCGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN", "length": 247, "header": "tr|G1K1L9-1|G1K1L9_BOVIN Computationally mapped isoform of chymotrypsin OS=Bos taurus OX=9913 GN=LOC100848132 PE=4 SV=2 CANONICAL=A0AAA9S678-1" }, "locus": { "chromosome": "18", "start_pos": 2567838, "end_pos": 2564913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015915.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015915.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015915.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015915.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 279, "start_aa": "Thr", "end_pos": 279, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr279", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100848132", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848132", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S678", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S678", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S678", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" } ], "pmid": "" }, { "name": "digestion", "id": "GO:0007586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007586", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S678", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S678" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 298, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.1", "ec_name": "Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.", "evidence": [ { "id": "3.4.21.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 279 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S694-1", "uniprot_ac": "A0AAA9S694", "uniprot_id": "A0AAA9S694_BOVIN", "mass": { "chemical_mass": 482944.0, "monoisotopic_mass": 482944.0 }, "refseq": {}, "gene_names": [ { "name": "MUC5B", "type": "recommended", "evidence": [ { "id": "A0AAA9S694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" } ] } ], "protein_names": [ { "name": "Mucin 5B, oligomeric mucus/gel-forming", "type": "recommended", "evidence": [ { "id": "A0AAA9S694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S694", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MUC5B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000008274", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008274", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19941", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19941", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11339:SF408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11339:SF408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13330", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13330", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25962", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25962", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5621480", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5621480", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-977068", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977068", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S694", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S694-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T006", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T006", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T006-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T006-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5A7", "url": "https://www.uniprot.org/uniprotkb/G5E5A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5A7-1", "url": "https://www.uniprot.org/uniprotkb/G5E5A7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "PFTARHLTFIPPITVFPTMSPLNAAHGGRVCSTWGDFHYKTFDGDVFRFPGLCNYIFSAHCGSAYEDFNLQLRRGLLGSRPTITHIVLRSQGLVLEVSNGSVLINGWREELPYSRAGLLVERSSTYVKINIRLMLTFMWNGEDSALLELDPKYANQTCGLCGDFNGLRAVSEFYAHNTRLSPLQFGNLQKLDGPTEQCQDPLPSPAADNCTDEEGVCRRTLLGPAFAPCHGLVDTEVYVAACTQDLCRCPTCPCATFAEYSRQCAHAGGQPQNWRGPDLCPQTCPLNTQHQECGSPCVDTCSNPERSQLCEDHCVDGCFCPPDTVLDDVTHTGCLPLRQCPCTHGGRTYAPGASFNTSCTSCTCSGGLWQCQDLPCPGTCSVQGGSHISTYDEKLYDVHGDCSYVLTKVCADSALTVLAELRKCGLTDNENCLKTVTLSLNGGDTVSEIQANGGVFVNSIYSQLPMSVADVTVFRPSSFFILVQTGPWLQLQVQLVPLMQVFLRLDPAYRGQMCGLCGNFNQNQADDFRTVSGVVEATAAAFANTWKTQAACPNVKNSFEDPCSLSVENENYAQHWCSLLTRPAGPFSPCHSVISPGPFHSNCLFDTCNCEKSEDCMCAALSSYVQACAARGVLLSGWRDGVCTKYASSCPKTQSYAHVVDSCQPTCRSLSQPDVSCDVAFVPVDGCVCPRGTFLDDAGDCVPAEACPCYLRGTVLAPGEVVHDNGVVCSCVSGRLSCLGATEQSTGCVAPMVFLDCSNASADAPGAECVRSCHTLDVDCFSTHCVSGCVCPVGLLSDGSGGCVAEEDCPCMHNEAAYKPGEVIKVDCNTCTCRGRRWECSDRPCLGTCVAYGDGHFLTFDGERYGFEGSCEYTLAQDYCVGSDTANGTFRIVTENVPCGTTGVTCSKAIKIFLGSYELILHEGTHRVLQRGPGGDLPYRVRYMGIYLTVETHGGVVVSWDRKTSVIIRLRHEYKGRVCGLCGNFDDNALNDFTTRSQSVASDVLEFGNSWKFSPSCPDALAPRDPCTTNPYRRSWAQKQCSIINSATFSACRSQVDPTRYYEACVSDACACDSGGDCECFCTAVAAYAQACHEAGVCVSWRTPDVCPLFCDYYNPHGQCEWHYQPCGAPCLKTCRNPSGLCLMDLPGLEGCYPKCPSSKPFFNEDQMECVAQCSGCYDGDGNYYDAGTRVPSTENCQSCDCTSSGLQCTHTCTCTYEGRTYAYGDVIYNTTDGLGACLIAICRDNGTIVRRAVECPGTLFKTPFTFTSTAAPPSTTGLVPTPSTVCVRKVCHWSDWYDGGHPEPGMSGGDFETFENLRQRGYQVCLAPVDIECQAQLLPGIPLEELGQKVECSRDKGLTCFNSEQSPPLCLNYKLRVLCCDYVPCGTSQPPSSQTTPTTGTTHPTMAVTTSQSPSTKLTTNTTPEGSSSVFPATTTCEPHCHWTEWFDVDYPKYEEGGGDLETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQQVHCDVRFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAAAVPTATVPTATTATVPTATVPTATTAAVPTATASTATAATATTATVPMTTSSIATATTATARTPTVPTATTTVTVPTATTVTVPTATSTTATISTAATSNATAPTAAVHPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHSTTSTVPTVTATTETVSTATASTATAATATTTGTATTATVPTATTATVPMATTSTATATVPTATTATVPTATTATVPTETTTTATVPTATTATTTTATVPRATTSTATATTATTATVPKATTATVPMAATSTAIVPRATTATATTTTVPTATTSTATAVTATTATVPTATTTTATISTAATSNATAPTAAVVTATTSTPAPTTATTGATTSQGMTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHSTMVTVPTATTSTATMPTATMATVPMATPSTSTATVPTTSTATTTVPIATTTTATVPTENATTVTVSIATPSTAPGTTTTAPTATVPTATTTTATVPTATTATVPTATATSATVPSATTATVPTTTASIATATTVTAPTSTVPTATTSTATAVTATTATVPTATTATVPTATTATVTTRTPSTQHPETSTPAPTTATTGATTSQGMTSCQPRCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAGTATVPTATTATTTTATVPTATTATVPTATPATTTSATVPTATTATIATVPTATTTTVPMATTATMPTATTATVPTATTVTTTTATVPTATTATVPTATTATVPTATTTTATVPTATTATVPTATSSTSTTTVPMATTYTATAGTATTAEVPMATTTTAIVPTATTAAVPTATTTTATVRTAATSTATVPTATTATVPTATTATVPTATTTTATVPTATTATVPTATSSTASAATATTAEVPMATTTTAIVPTATTATVPTATTTIATVPTATTATTSTATVPTATTATVPTATTASVPMATTATVPSATTSTATISTAATSNATAPTAAVVTATVPTAAISTGTVPTASAASSTTSTAVPTPTQTRTQTGSTVVTGSPASSATPVPALSTRLTTQVTASSPGQTGTHPTSPPGSTGSTSPGTAMSVLPTQKTSQGPTSVSATTQTSTAWPPTETALSTTRTPSTQHPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQQVHCDIRLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAATATVPTATPATTTSATVPTATTATIATVPTATTTTVPMATTATVPTATTATVPTATTTTATVPTATTATVPTATTATTTTATVPTATIATVPTATATTATVPTATTATTTTATVPTATTATVPMATSSTATTTVPMATTYTATAGTATTAEVPMATTTTAIVPTATTAAVPTATTTTATVPTATTTIATVPTATTATTSTATVPTATSATVPTATTASVPMATTATVPSATTSTATISIAATSNATAPTAAVVTATVPTAAISTGTVPTASAASSTTSTAVPTPTQTRTQTGSTVVTGSPASSATPVPALSTRLTTQVTASSPGHTGTHPTSLPGSTGSTSPGTATSVLLTQKTSQGPTSVLATTQTSTARLPTEIALSTTYTRSTQQPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDFPTSGVMGGDIETYDNIRAAGGKMCQDPEKIECRAENYPEVSIDQIGQVLNCSLETGLVCRNEDQRGPFTMCFNYNIRVYCCDDVRHCPTTATPGLRSTSLPPVTVVTSHILESTSVTNLPPSPVMPTTRSTTCERRCAWTDWMDKSYPMPGAYGGDYETYANIQAAGGAICEQPLKLECRAEELPDIPLPDLGQVVLCQLEVGLVCRNQDQSGQMCLNYQIRLLCCDKSYCPSTAITTSTPTSETGLSSTVTTGRVSIPTSVTGPSSTVTTERVSTPMSLPGPSSMVTSGVVSTTTSVTGPSSKATTKRVSTQTSGSLMPSIVPTTSPGPTTPCLCHAFGKFFLPGDIVYNKTDGAGCPFLAICNQRCDLDRFQGACTTSSPPGTSASVPPTTPLSDCDRTIPPRKVNESWFLEDCTVARCEGDNRVTLLGPRPMSSITCVNGHLPVKVQNQSHRCDYHYECECVCSGWGDTHYETFDGTSYSFWDNCTYVLMREIQPRHGNLRILLHNRFCEATAHCPRALSIHYQSVDIVLSTTSSAILLDQTRMRQSFSKNGVIVTLTGATGMRVDIPAVGVGITFNGRVFQARLSYSRFSHNTEGQCGTCTNNRRDECRRPDGTTARTCRDMARSWLVSNSSVEGCGVPTGLPPTTSPLLPETSTPAIHPSCPPEPLCELMLSSVFAGCHSLIPPGPYFNACVSDSCWPGRGRKVLCQSLEAYAELCRSRGVCPDWRNATHGLCDLTCPSAKVYKSCGPVQPESCDSRSQSPLSVGLAEGCFCPDGHILFNSHRDICVPECPCVGPDGLPKFPGERWVSNCQDCVCDNGTVSVQCTPVECLAPDQPQQCGRAGFVAVSRPLADNPCCMENLCVCNASTCPQSPPACRLGEKLVRTQVEDDCCPTFSCEPLLCTFNGTFYGVRAPCPGVTPCHTCTCLSMDSEDLTVRCEEEACNTTCLQGFEYSTVAGQCCGECVQTACLAPDGQLVQLNETWVNSLVDNCTEYHCQARDGPPMLTPMPVVCPDVSTCKGILKKIGCCYYCVQTDACQVHTNMTVLRHRGCVTQAAVKVSFCEGSCPKVSRYSMEAQARQCSCSCCQETRTHQEVVTMQCPDGTAFQHTYTHVDECSCVPACASSPQTLEDSSSTFPVLGFTTV", "length": 4622, "header": "tr|A0AAA9S694-1|A0AAA9S694_BOVIN Isoform 1 of Mucin 5B, oligomeric mucus/gel-forming OS=Bos taurus OX=9913 GN=MUC5B PE=4 SV=1 CANONICAL=A0AAA9S694-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S694-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694/entry#A0AAA9S694-1", "sequence": { "sequence": "PFTARHLTFIPPITVFPTMSPLNAAHGGRVCSTWGDFHYKTFDGDVFRFPGLCNYIFSAHCGSAYEDFNLQLRRGLLGSRPTITHIVLRSQGLVLEVSNGSVLINGWREELPYSRAGLLVERSSTYVKINIRLMLTFMWNGEDSALLELDPKYANQTCGLCGDFNGLRAVSEFYAHNTRLSPLQFGNLQKLDGPTEQCQDPLPSPAADNCTDEEGVCRRTLLGPAFAPCHGLVDTEVYVAACTQDLCRCPTCPCATFAEYSRQCAHAGGQPQNWRGPDLCPQTCPLNTQHQECGSPCVDTCSNPERSQLCEDHCVDGCFCPPDTVLDDVTHTGCLPLRQCPCTHGGRTYAPGASFNTSCTSCTCSGGLWQCQDLPCPGTCSVQGGSHISTYDEKLYDVHGDCSYVLTKVCADSALTVLAELRKCGLTDNENCLKTVTLSLNGGDTVSEIQANGGVFVNSIYSQLPMSVADVTVFRPSSFFILVQTGPWLQLQVQLVPLMQVFLRLDPAYRGQMCGLCGNFNQNQADDFRTVSGVVEATAAAFANTWKTQAACPNVKNSFEDPCSLSVENENYAQHWCSLLTRPAGPFSPCHSVISPGPFHSNCLFDTCNCEKSEDCMCAALSSYVQACAARGVLLSGWRDGVCTKYASSCPKTQSYAHVVDSCQPTCRSLSQPDVSCDVAFVPVDGCVCPRGTFLDDAGDCVPAEACPCYLRGTVLAPGEVVHDNGVVCSCVSGRLSCLGATEQSTGCVAPMVFLDCSNASADAPGAECVRSCHTLDVDCFSTHCVSGCVCPVGLLSDGSGGCVAEEDCPCMHNEAAYKPGEVIKVDCNTCTCRGRRWECSDRPCLGTCVAYGDGHFLTFDGERYGFEGSCEYTLAQDYCVGSDTANGTFRIVTENVPCGTTGVTCSKAIKIFLGSYELILHEGTHRVLQRGPGGDLPYRVRYMGIYLTVETHGGVVVSWDRKTSVIIRLRHEYKGRVCGLCGNFDDNALNDFTTRSQSVASDVLEFGNSWKFSPSCPDALAPRDPCTTNPYRRSWAQKQCSIINSATFSACRSQVDPTRYYEACVSDACACDSGGDCECFCTAVAAYAQACHEAGVCVSWRTPDVCPLFCDYYNPHGQCEWHYQPCGAPCLKTCRNPSGLCLMDLPGLEGCYPKCPSSKPFFNEDQMECVAQCSGCYDGDGNYYDAGTRVPSTENCQSCDCTSSGLQCTHTCTCTYEGRTYAYGDVIYNTTDGLGACLIAICRDNGTIVRRAVECPGTLFKTPFTFTSTAAPPSTTGLVPTPSTVCVRKVCHWSDWYDGGHPEPGMSGGDFETFENLRQRGYQVCLAPVDIECQAQLLPGIPLEELGQKVECSRDKGLTCFNSEQSPPLCLNYKLRVLCCDYVPCGTSQPPSSQTTPTTGTTHPTMAVTTSQSPSTKLTTNTTPEGSSSVFPATTTCEPHCHWTEWFDVDYPKYEEGGGDLETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQQVHCDVRFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAAAVPTATVPTATTATVPTATVPTATTAAVPTATASTATAATATTATVPMTTSSIATATTATARTPTVPTATTTVTVPTATTVTVPTATSTTATISTAATSNATAPTAAVHPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHSTTSTVPTVTATTETVSTATASTATAATATTTGTATTATVPTATTATVPMATTSTATATVPTATTATVPTATTATVPTETTTTATVPTATTATTTTATVPRATTSTATATTATTATVPKATTATVPMAATSTAIVPRATTATATTTTVPTATTSTATAVTATTATVPTATTTTATISTAATSNATAPTAAVVTATTSTPAPTTATTGATTSQGMTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHSTMVTVPTATTSTATMPTATMATVPMATPSTSTATVPTTSTATTTVPIATTTTATVPTENATTVTVSIATPSTAPGTTTTAPTATVPTATTTTATVPTATTATVPTATATSATVPSATTATVPTTTASIATATTVTAPTSTVPTATTSTATAVTATTATVPTATTATVPTATTATVTTRTPSTQHPETSTPAPTTATTGATTSQGMTSCQPRCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAGTATVPTATTATTTTATVPTATTATVPTATPATTTSATVPTATTATIATVPTATTTTVPMATTATMPTATTATVPTATTVTTTTATVPTATTATVPTATTATVPTATTTTATVPTATTATVPTATSSTSTTTVPMATTYTATAGTATTAEVPMATTTTAIVPTATTAAVPTATTTTATVRTAATSTATVPTATTATVPTATTATVPTATTTTATVPTATTATVPTATSSTASAATATTAEVPMATTTTAIVPTATTATVPTATTTIATVPTATTATTSTATVPTATTATVPTATTASVPMATTATVPSATTSTATISTAATSNATAPTAAVVTATVPTAAISTGTVPTASAASSTTSTAVPTPTQTRTQTGSTVVTGSPASSATPVPALSTRLTTQVTASSPGQTGTHPTSPPGSTGSTSPGTAMSVLPTQKTSQGPTSVSATTQTSTAWPPTETALSTTRTPSTQHPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQQVHCDIRLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAATATVPTATPATTTSATVPTATTATIATVPTATTTTVPMATTATVPTATTATVPTATTTTATVPTATTATVPTATTATTTTATVPTATIATVPTATATTATVPTATTATTTTATVPTATTATVPMATSSTATTTVPMATTYTATAGTATTAEVPMATTTTAIVPTATTAAVPTATTTTATVPTATTTIATVPTATTATTSTATVPTATSATVPTATTASVPMATTATVPSATTSTATISIAATSNATAPTAAVVTATVPTAAISTGTVPTASAASSTTSTAVPTPTQTRTQTGSTVVTGSPASSATPVPALSTRLTTQVTASSPGHTGTHPTSLPGSTGSTSPGTATSVLLTQKTSQGPTSVLATTQTSTARLPTEIALSTTYTRSTQQPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDFPTSGVMGGDIETYDNIRAAGGKMCQDPEKIECRAENYPEVSIDQIGQVLNCSLETGLVCRNEDQRGPFTMCFNYNIRVYCCDDVRHCPTTATPGLRSTSLPPVTVVTSHILESTSVTNLPPSPVMPTTRSTTCERRCAWTDWMDKSYPMPGAYGGDYETYANIQAAGGAICEQPLKLECRAEELPDIPLPDLGQVVLCQLEVGLVCRNQDQSGQMCLNYQIRLLCCDKSYCPSTAITTSTPTSETGLSSTVTTGRVSIPTSVTGPSSTVTTERVSTPMSLPGPSSMVTSGVVSTTTSVTGPSSKATTKRVSTQTSGSLMPSIVPTTSPGPTTPCLCHAFGKFFLPGDIVYNKTDGAGCPFLAICNQRCDLDRFQGACTTSSPPGTSASVPPTTPLSDCDRTIPPRKVNESWFLEDCTVARCEGDNRVTLLGPRPMSSITCVNGHLPVKVQNQSHRCDYHYECECVCSGWGDTHYETFDGTSYSFWDNCTYVLMREIQPRHGNLRILLHNRFCEATAHCPRALSIHYQSVDIVLSTTSSAILLDQTRMRQSFSKNGVIVTLTGATGMRVDIPAVGVGITFNGRVFQARLSYSRFSHNTEGQCGTCTNNRRDECRRPDGTTARTCRDMARSWLVSNSSVEGCGVPTGLPPTTSPLLPETSTPAIHPSCPPEPLCELMLSSVFAGCHSLIPPGPYFNACVSDSCWPGRGRKVLCQSLEAYAELCRSRGVCPDWRNATHGLCDLTCPSAKVYKSCGPVQPESCDSRSQSPLSVGLAEGCFCPDGHILFNSHRDICVPECPCVGPDGLPKFPGERWVSNCQDCVCDNGTVSVQCTPVECLAPDQPQQCGRAGFVAVSRPLADNPCCMENLCVCNASTCPQSPPACRLGEKLVRTQVEDDCCPTFSCEPLLCTFNGTFYGVRAPCPGVTPCHTCTCLSMDSEDLTVRCEEEACNTTCLQGFEYSTVAGQCCGECVQTACLAPDGQLVQLNETWVNSLVDNCTEYHCQARDGPPMLTPMPVVCPDVSTCKGILKKIGCCYYCVQTDACQVHTNMTVLRHRGCVTQAAVKVSFCEGSCPKVSRYSMEAQARQCSCSCCQETRTHQEVVTMQCPDGTAFQHTYTHVDECSCVPACASSPQTLEDSSSTFPVLGFTTV", "length": 4622, "header": "tr|A0AAA9S694-1|A0AAA9S694_BOVIN Isoform 1 of Mucin 5B, oligomeric mucus/gel-forming OS=Bos taurus OX=9913 GN=MUC5B PE=4 SV=1 CANONICAL=A0AAA9S694-1" }, "locus": { "chromosome": "29", "start_pos": 50228102, "end_pos": 50191549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134442.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134442.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077691.1" } ] } }, { "isoform_ac": "A0AAA9T006-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694/entry#A0AAA9T006-1", "sequence": { "sequence": "PFTARHLTFIPPITVFPTMSPLNAAHGGRVCSTWGDFHYKTFDGDVFRFPGLCNYIFSAHCGSAYEDFNLQLRRGLLGSRPTITHIVLRSQGLVLEVSNGSVLINGWREELPYSRAGLLVERSSTYVKINIRLMLTFMWNGEDSALLELDPKYANQTCGLCGDFNGLRAVSEFYAHNTRLSPLQFGNLQKLDGPTEQCQDPLPSPAADNCTDEEGVCRRTLLGPAFAPCHGLVDTEVYVAACTQDLCRCPTCPCATFAEYSRQCAHAGGQPQNWRGPDLCPQTCPLNTQHQECGSPCVDTCSNPERSQLCEDHCVDGCFCPPDTVLDDVTHTGCLPLRQCPCTHGGRTYAPGASFNTSCTSCTCSGGLWQCQDLPCPGTCSVQGGSHISTYDEKLYDVHGDCSYVLTKVCADSALTVLAELRKCGLTDNENCLKTVTLSLNGGDTVSEIQANGGVFVNSIYSQLPMSVADVTVFRPSSFFILVQTGPWLQLQVQLVPLMQVFLRLDPAYRGQMCGLCGNFNQNQADDFRTVSGVVEATAAAFANTWKTQAACPNVKNSFEDPCSLSVENENYAQHWCSLLTRPAGPFSPCHSVISPGPFHSNCLFDTCNCEKSEDCMCAALSSYVQACAARGVLLSGWRDGVCTKYASSCPKTQSYAHVVDSCQPTCRSLSQPDVSCDVAFVPVDGCVCPRGTFLDDAGDCVPAEACPCYLRGTVLAPGEVVHDNGVVCSCVSGRLSCLGATEQSTGCVAPMVFLDCSNASADAPGAECVRSCHTLDVDCFSTHCVSGCVCPVGLLSDGSGGCVAEEDCPCMHNEAAYKPGEVIKVDCNTCTCRGRRWECSDRPCLGTCVAYGDGHFLTFDGERYGFEGSCEYTLAQDYCVGSDTANGTFRIVTENVPCGTTGVTCSKAIKIFLGSYELILHEGTHRVLQRGPGGDLPYRVRYMGIYLTVETHGGVVVSWDRKTSVIIRLRHEYKGRVCGLCGNFDDNALNDFTTRSQSVASDVLEFGNSWKFSPSCPDALAPRDPCTTNPYRRSWAQKQCSIINSATFSACRSQVDPTRYYEACVSDACACDSGGDCECFCTAVAAYAQACHEAGVCVSWRTPDVCPLFCDYYNPHGQCEWHYQPCGAPCLKTCRNPSGLCLMDLPGLEGCYPKCPSSKPFFNEDQMECVAQCSGCYDGDGNYYDAGTRVPSTENCQSCDCTSSGLQCTHTCTCTYEGRTYAYGDVIYNTTDGLGACLIAICRDNGTIVRRAVECPGTLFKTPFTFTSTAAPPSTTGLVPTPSTVCVRKVCHWSDWYDGGHPEPGMSGGDFETFENLRQRGYQVCLAPVDIECQAQLLPGIPLEELGQKVECSRDKGLTCFNSEQSPPLCLNYKLRVLCCDYVPCGTSQPPSSQTTPTTGTTHPTMAVTTSQSPSTKLTTNTTPEGSSSVFPATTTCEPHCHWTEWFDVDYPKYEEGGGDLETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQQVHCDVRFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAAAVPTATVPTATTATVPTATVPTATTAAVPTATASTATAATATTATVPMTTSSIATATTATARTPTVPTATTTVTVPTATTVTVPTATSTTATISTAATSNATAPTAAVHPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHSTTSTVPTVTATTETVSTATASTATAATATTTGTATTATVPTATTATVPMATTSTATATVPTATTATVPTATTATVPTETTTTATVPTATTATTTTATVPRATTSTATATTATTATVPKATTATVPMAATSTAIVPRATTATATTTTVPTATTSTATAVTATTATVPTATTTTATISTAATSNATAPTAAVVTATTSTPAPTTATTGATTSQGMTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHFGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATATTATVPTATMATTTTATAPTATMVTVPTATTSTATMPTATMATVPMATPSTSTATVPTTSTATTTVPIATTTTATVPTENATTVTVSIATPSTAPGTTTTAPTATVPTATTTTATVPTATTATVPTATATSATVPSATTATVPTTTASIATATTVTAPTSTVPTATTSTATAVTATTATVPTATTATVPTATTATVSMATTTTTASVPTATTATVPTATTTTTATVRTPTTATVTMATATTATVPMATISTATATVPMATTAIATISTAATSNATAPTATVVTATVPTAAISTGTVPTASAASSTTSTAVPTPTQTRTQTGSTVVTGSPASSATPVPALSTQLTTQVTASSSGHTGTHPTSPPGSTGSTSPGTATSVLPTRKTSQGPTSVSATTQTSTARPPTETAVSTTRTPSTQHPETSTPAPTTATTGATTSQGMTSCQPRCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAVPTATSSTSTTTVPMATTYTATAGTATTAEVPMATTTTAIVPTATTAAVPTATTTTATVRTAATSTATVPTATTATVPTATTATVPTATTTTATVPTATTATVPTATSSTASAATATTAEVPMATTTTAIVPTATTATVPTATTTIATTSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQQVHCDIRLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTATATASTATAATATVPTATPKTSQGPTSVLATTQTSTARLPTEIALSTTYTRSTQQPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDFPTSGVMGGDIETYDNIRAAGGKMCQDPEKIECRAENYPEVSIDQIGQVLNCSLETGLVCRNEDQRGPFTMCFNYNIRVYCCDDVRHCPTTATPGLRSTSLPPVTVVTSHILESTSVTNLPPSPVMPTTRSTTCERRCAWTDWMDKSYPMPGAYGGDYETYANIQAAGGAICEQPLKLECRAEELPDIPLPDLGQVVLCQLEVGLVCRNQDQSGQMCLNYQIRLLCCDKSYCPSTAITTSTPTSETGLSSTVTTGRVSIPTSVTGPSSTVTTERVSTPMSLPGPSSMVTSGVVSTTTSVTGPSSKATTKRVSTQTSGSLMPSIVPTTSPGPTTPCLCHAFGKFFLPGDIVYNKTDGAGCPFLAICNQRCDLDRFQGACTTSSPPGTSASVPPTTPLSDCDRTIPPRKVNESWFLEDCTVARCEGDNRVTLLGPRPMSSITCVNGHLPVKVQNQSHRCDYHYECECVCSGWGDTHYETFDGTSYSFWDNCTYVLMREIQPRHGNLRILLHNRFCEATAHCPRALSIHYQSVDIVLSTTSSAILLDQTRMRQSFSKNGVIVTLTGATGMRVDIPAVGVGITFNGRVFQARLSYSRFSHNTEGQCGTCTNNRRDECRRPDGTTARTCRDMARSWLVSNSSVEGCGVPTGLPPTTSPLLPETSTPAIHPSCPPEPLCELMLSSVFAGCHSLIPPGPYFNACVSDSCWPGRGRKVLCQSLEAYAELCRSRGVCPDWRNATHGLCDLTCPSAKVYKSCGPVQPESCDSRSQSPLSVGLAEGCFCPDGHILFNSHRDICVPECPCVGPDGLPKFPGERWVSNCQDCVCDNGTVSVQCTPVECLAPDQPQQCGRAGFVAVSRPLADNPCCMENLCVCNASTCPQSPPACRLGEKLVRTQVEDDCCPTFSCEPLLCTFNGTFYGVRAPCPGVTPCHTCTCLSMDSEDLTVRCEEEACNTTCLQGFEYSTVAGQCCGECVQTACLAPDGQLVQLNETWVNSLVDNCTEYHCQARDGPPMLTPMPVVCPDVSTCKGILKKIGCCYYCVQTDACQVHTNMTVLRHRGCVTQAAVKVSFCEGSCPKVSRYSMEAQARQCSCSCCQETRTHQEVVTMQCPDGTAFQHTYTHVDECSCVPACASSPQTLEDSSSTFPVLGFTTV", "length": 4198, "header": "tr|A0AAA9T006-1|A0AAA9T006_BOVIN Computationally mapped isoform of Mucin 5B, oligomeric mucus/gel-forming OS=Bos taurus OX=9913 GN=MUC5B PE=4 SV=1 CANONICAL=A0AAA9S694-1" }, "locus": { "chromosome": "29", "start_pos": 50228102, "end_pos": 50191549, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109171.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109171.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092059.1" } ] } }, { "isoform_ac": "G5E5A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694/entry#G5E5A7-1", "sequence": { "sequence": "VHTTAAPHHRALPTALNAAHGGRVCSTWGDFHYKTFDGDVFRFPGLCNYIFSAHCGSAYEDFNLQLRRGLLGSRPTITHIVLRSQGLVLEVSNGSVLINGWREELPYSRAGLLVERSSTYVKINIRLMLTFMWNGEDSALLELDPKYANQTCGLCGDFNGLRAVSEFYAHNTRLSPLQFGNLQKLDGPTEQCQDPLPSPAADNCTDEGVCRRTLLGPAFAPCHGLVDTEVYVAACTQDLCRCPTCPCATFAEYSRQCAHAGGQPQNWRGPDLCPQTCPLNTQHQECGSPCVDTCSNPERSQLCEDHCVDGCFCPPDTVLDDVTHTGCLPLRQCPCTHGGRTYAPGASFNTSCTSCTCSGGLWQCQDLPCPGTCSVQGGSHISTYDEKLYDVHGDCSYVLTKVCADSALTVLAELRKCGLTDNENCLKTVTLSLNGGDTVSEAPANGGVFVNSIYSQLPMSVADVTVFRPSSFFILVQTGPWLQLQVQLVPLMQVFLRLDPAYRGQMCGLCGNFNQNQADDFRTVSGVVEATAAAFANTWKTQAACPNVKNSFEDPCSLSVENENYAQHWCSLLTRPAGPFSPCHSVISPGPFHSNCLFDTCNCEKSEDCMCAALSSYVQACAARGVLLSGWRDGVCTKYASSCPKTQSYAHVVDSCQPTCRSLSQPDVSCDVAFVPVDGCVCPRGTFLDDAGDCVPAEACPCYLRGTVLAPGEVVHDNGVVCSCVSGRLSCLGATDMAVSTGCVAPMVFLDCSNASADAPGAECVRSCHTLDVDCFSTHCVSGCVCPVGLLSDGSGGCVAEEDCPCMHNEAAYKPGEVIKVDCNTCTCRGRRWECSDRPCLGTCVAYGDGHFLTFDGERYGFEGSCEYTLAQDYCVGSDTANGTFRIVTENVPCGTTGVTCSKAIKIFLGSYELILHEGTHRVLQRGPGGDLPYRVRYMGIYLTVETHGGVVVSWDRKTSVIIRLRHEYKGRVCGLCGNFDDNALNDFTTRSQSVASDVLEFGNSWKFSPSCPDALAPRDPCTTNPYRRSWAQKQCSIINSATFSACRSQVDPTRYYEACVSDACACDSGGDCECFCTAVAAYAQACHEAGVCVSWRTPDVCPLFCDYYNPHGQCEWHYQPCGAPCLKTCRNPSGLCLMDLPGLEGCYPKCPSSKPFFNEDQMECVAQCSGCYDGDGNYYDAGTRVPSTENCQSCDCTSSGLQCTHSPEACTCTYEGRTYAYGDVIYNTTDGLGACLIAICRDNGTIVRRAVECPGTLFKTPFTFTSTAAPPSTTGEPGRHTTGSALPLGPWALPAVCHWSDWYDGGHPEPGMSGGDFETFENLRQRGYQVCLAPVDIECQAQLLPGIPLEELGQKVECSRDKGLTCFNSEQSPPLCLNYKLRVLCCDYVPCVPALSTRLTTQVTALSPGQTGTHPTSPPGSTGSTSPGTATSVLPTRKTSQGPTSVSATTQTSTAWPTTRTPSTQHPETSTPAPTTATTGATTSQGMTSCQPRCKWTEWFDVDYPKYEEGGGDFETYEKIRGAGGAVCKQPQEIECEAENYPGLTPEQVGQRVHCDVHLGLVCRNDEQLGLFKMCYNYRMRVLCCEYNHCTLPTATTSPTGPTSVSATTQTSTAWPPTETALSTTRTPSTQHPETSTPAPTTATTGATTSQGTTSCQPKCKWTEWFDVDYPKYEEGGGDFETYEKIRGGKMCQDPEKIECRAENYPEVSIDQIGQVLNCSLETGLVCRNEDQRGPFTMCFNYNIRVYCCDDVRHCPTTATPGLRSTSLPPGSSTATGPWPPTSTTTWPPFSSSKVLPMTPKPTLTGAPSTVTVVTSHILESTSVTNLPPSPVMPTTRATTHTQFLPPTTSKGMTQITELPTRPSETTTRPPVTTLSTGQATSHTGVGTSTSLSPPGPEPSTSSLGTTLGPTTTTTSMATLSSPKTHTSGTTLVPTSPGTESTTCERRCAWTDWMDKSYPMPGAYGGDYETYANIQAAGGAICEQPLKLECRAEELPDIPLPDLGQVVLCQLEVGLVCRNQDQSGQMCLNYQIRLLCCDKSYCPSTAITTSTPTSETGLSSTVTTGRVSIPTSVTGPSSTVTTERVSTPMSLPGPSSMESTQGPSPARRQRPPCPRQGVVPVAEVGAVGRGPAIPPCGCCAVSQVNESWFLEDCTVARCEGDNRVTLLGPRPMSSITCVNGHLPVKVQNQSHRCDYHYECECVCSGWGDTHYETFDGTSYSFWDNCTYVLMREIQPRHGNLRILLHNRFCEATAHCPRALSIHYQSVDIVLSTTSSAAGRGPSTWEHSPGSFSKNGVIVTLTGATGMRVDIPAVGVGITFNGRVFQARLSYSRFSHNTEGQCGTCTNNRRDECRRPDGTTARTCRDMARSWLVSNSSVEGCGVPTGLPPTTSPLLPETSTPAIHPSCPPEPLCELMLSSVFAGCHSLIPPGPYFNACVSDSCWPGRGRKVLCQSLEAYAELCRSRGVCPDWRNATHGLCGESGVAAGGPGLLGLPDTCLCAPRPHLPVRQGVQVLWPCAAGVLRLQVSPADRESMVGTAGLPGWPGGPGGEPGGDPRGSRTPTPNLGGALPPPDLRPRTRGCPWACTLPTALPLSLPLSPCRSQSPLSVGLAEGCFCPDGHILFNSHRDICVPECRKHPAPGPPSPRERKGPRGGQTPAGASPAQSCQQRSMAWSLSESPPK", "length": 2682, "header": "tr|G5E5A7-1|G5E5A7_BOVIN Computationally mapped isoform of VWFD domain-containing protein OS=Bos taurus OX=9913 GN=MUC5B PE=4 SV=3 CANONICAL=A0AAA9S694-1" }, "locus": { "chromosome": "29", "start_pos": 50228354, "end_pos": 50195348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010897.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010897.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010897.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010897.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1282, "start_aa": "Thr", "end_pos": 1282, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1673, "start_aa": "Thr", "end_pos": 1673, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1673", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1677, "start_aa": "Thr", "end_pos": 1677, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1677", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1993, "start_aa": "Thr", "end_pos": 1993, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1993", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2135, "start_aa": "Thr", "end_pos": 2135, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2135", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2297, "start_aa": "Thr", "end_pos": 2297, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2297", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2301, "start_aa": "Thr", "end_pos": 2301, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2466, "start_aa": "Thr", "end_pos": 2466, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2466", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2908, "start_aa": "Thr", "end_pos": 2908, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2908", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2912, "start_aa": "Thr", "end_pos": 2912, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2912", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3056, "start_aa": "Thr", "end_pos": 3056, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3056", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3441, "start_aa": "Thr", "end_pos": 3441, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3441", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3445, "start_aa": "Thr", "end_pos": 3445, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3445", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3566, "start_aa": "Thr", "end_pos": 3566, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3566", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3805, "start_aa": "Thr", "end_pos": 3805, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3805", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 4133, "start_aa": "Thr", "end_pos": 4133, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4133", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5621480", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5621480", "resource": "Reactome", "description": "Dectin-2 family" }, { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" }, { "id": "R-BTA-977068", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977068", "resource": "Reactome", "description": "Termination of O-glycan biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S694", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S694", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S694", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S694", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1230, "end_pos": 1232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1246, "end_pos": 1248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1422, "end_pos": 1424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1659, "end_pos": 1661, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1790, "end_pos": 1792, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1974, "end_pos": 1976, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2106, "end_pos": 2108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2167, "end_pos": 2169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2759, "end_pos": 2761, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3292, "end_pos": 3294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3524, "end_pos": 3526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3825, "end_pos": 3827, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3882, "end_pos": 3884, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3925, "end_pos": 3927, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3961, "end_pos": 3963, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4108, "end_pos": 4110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4206, "end_pos": 4208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4296, "end_pos": 4298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4343, "end_pos": 4345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4383, "end_pos": 4385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4422, "end_pos": 4424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4458, "end_pos": 4460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4468, "end_pos": 4470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4520, "end_pos": 4522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 759, "end_pos": 761, "annotation": "n_glycosylation_sequon" }, { "start_pos": 887, "end_pos": 889, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" }, { "id": "PS01225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTCK", "eco_id": "ECO_0000259", "start_pos": 4509, "end_pos": 4601, "start_aa": "Cys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 4271, "end_pos": 4341, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S694" }, { "id": "PS51233", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51233" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFD", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 199, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1282, 1673, 1677, 1993, 2135, 2297, 2301, 2466, 2908, 2912, 3056, 3441, 3445, 3566, 3805, 4133 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1230, "end_pos": 1232 }, { "start_pos": 1246, "end_pos": 1248 }, { "start_pos": 1422, "end_pos": 1424 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 1659, "end_pos": 1661 }, { "start_pos": 1790, "end_pos": 1792 }, { "start_pos": 1974, "end_pos": 1976 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 2106, "end_pos": 2108 }, { "start_pos": 2167, "end_pos": 2169 }, { "start_pos": 2759, "end_pos": 2761 }, { "start_pos": 3292, "end_pos": 3294 }, { "start_pos": 3524, "end_pos": 3526 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 3825, "end_pos": 3827 }, { "start_pos": 3882, "end_pos": 3884 }, { "start_pos": 3925, "end_pos": 3927 }, { "start_pos": 3961, "end_pos": 3963 }, { "start_pos": 4108, "end_pos": 4110 }, { "start_pos": 4206, "end_pos": 4208 }, { "start_pos": 4296, "end_pos": 4298 }, { "start_pos": 4343, "end_pos": 4345 }, { "start_pos": 4383, "end_pos": 4385 }, { "start_pos": 4422, "end_pos": 4424 }, { "start_pos": 4458, "end_pos": 4460 }, { "start_pos": 4468, "end_pos": 4470 }, { "start_pos": 4520, "end_pos": 4522 }, { "start_pos": 759, "end_pos": 761 }, { "start_pos": 887, "end_pos": 889 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 16 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 16 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 16 }, { "field": "exact_o_linked_sites", "count": 16 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 16 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 16 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 16 }, { "field": "exact_o_linked_sites", "count": 16 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6A0-1", "uniprot_ac": "A0AAA9S6A0", "uniprot_id": "A0AAA9S6A0_BOVIN", "mass": { "chemical_mass": 35490.0, "monoisotopic_mass": 35490.0 }, "refseq": { "ac": "NP_001376778", "name": "olfactory receptor family 5 subfamily M member 9", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376778" }, "gene_names": [ { "name": "OR5M9", "type": "recommended", "evidence": [ { "id": "A0AAA9S6A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0" } ] }, { "name": "OR5M9", "type": "synonym", "evidence": [ { "id": "NP_001376778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376778" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S6A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 5 subfamily M member 9", "type": "synonym", "evidence": [ { "id": "NP_001376778", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376778" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376778" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5M9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0", "locus": { "chromosome": "15", "start_pos": 242523, "end_pos": 243464, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064372", "url": "https://www.ensembl.org/id/ENSBTAG00000064372" } ] } } ], "crossref": [ { "id": "A0AAA9S6A0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6A0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15412", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15412", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509895", "url": "https://www.ncbi.nlm.nih.gov/gene/509895", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509895", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509895", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376778", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAMPNFTDVTEFILLGLTSHQELQVLFFVVFLVVYMITLIGNIGMIILISISPQLQSPMYFFLSHLSFVDVWFSSNVTPKMLENILSETKTISYVGCLVQCYFFIALVHVEVYILAVMAFDRYMAICNPLPYGSKMSRTVCAHLISVPYIYGFSVSLICTLWTYGLYFCGNFKINHFYCADPPLIKIACGGVHIKEYTMIVIAGINFTYSLSVVLVSYTLIIAAMLRMRSADGRRKAFSTCGSHLTAVTMFYGTLIFMYLRRPTQESVEQGKMVAVFYTTVIPMLNPMIYSLRNKDVKEAVNKAIIKANLRQ", "length": 313, "header": "tr|A0AAA9S6A0-1|A0AAA9S6A0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5M9 PE=3 SV=1 CANONICAL=A0AAA9S6A0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0/entry#A0AAA9S6A0-1", "sequence": { "sequence": "MKAMPNFTDVTEFILLGLTSHQELQVLFFVVFLVVYMITLIGNIGMIILISISPQLQSPMYFFLSHLSFVDVWFSSNVTPKMLENILSETKTISYVGCLVQCYFFIALVHVEVYILAVMAFDRYMAICNPLPYGSKMSRTVCAHLISVPYIYGFSVSLICTLWTYGLYFCGNFKINHFYCADPPLIKIACGGVHIKEYTMIVIAGINFTYSLSVVLVSYTLIIAAMLRMRSADGRRKAFSTCGSHLTAVTMFYGTLIFMYLRRPTQESVEQGKMVAVFYTTVIPMLNPMIYSLRNKDVKEAVNKAIIKANLRQ", "length": 313, "header": "tr|A0AAA9S6A0-1|A0AAA9S6A0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5M9 PE=3 SV=1 CANONICAL=A0AAA9S6A0-1" }, "locus": { "chromosome": "15", "start_pos": 243464, "end_pos": 242526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102821.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102821.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078822.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509895", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509895", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 291, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 }, { "start_pos": 6, "end_pos": 8 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6A2-1", "uniprot_ac": "A0AAA9S6A2", "uniprot_id": "A0AAA9S6A2_BOVIN", "mass": { "chemical_mass": 48906.0, "monoisotopic_mass": 48906.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Homeobox domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S6A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6A2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6A2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46123:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46123:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6A2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARARVSPEKPGSRRRRLVLKPSQKDALQALFQQNPYPGIATRERLARELGIDESRVQVWFQNQRRRRSKQSRPPSEHVRQEGEGGPTEARRKRTVISPSQTRILVQAFTRDRFPGIAAREELARQTGIPEPRIQIWFQNRRARHPQRSPSGPGNGRAQGPGGAPATTTTPAPEDRRAPPAVQSTSPPLRPSQPQESMPPLAAAAPFGAPTFWVPGAASGVCVGQPLMIFVVQPSPAALQPSGRPPPPPQGAAPWAACSPAVTAPGLPGQGAILPPGQPETHIPRWPESPSGEGTAPPLEPQPQAPSLPSSTSLLDELLAATGVPDTQAPSPGAAADEGVGPALPGAPSFLDELLAATGTPDTPGPSLGPSADERAHLALPGELLAAAGLPGSPGPSPGSSPVVAGPHPALPGPPSLLEEILAATAIQDTPWSSPGSPAGEEGVEATLETPLSEDEYQALLDMLPGSPGPGA", "length": 472, "header": "tr|A0AAA9S6A2-1|A0AAA9S6A2_BOVIN Isoform 1 of Homeobox domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6A2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6A2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2/entry#A0AAA9S6A2-1", "sequence": { "sequence": "MARARVSPEKPGSRRRRLVLKPSQKDALQALFQQNPYPGIATRERLARELGIDESRVQVWFQNQRRRRSKQSRPPSEHVRQEGEGGPTEARRKRTVISPSQTRILVQAFTRDRFPGIAAREELARQTGIPEPRIQIWFQNRRARHPQRSPSGPGNGRAQGPGGAPATTTTPAPEDRRAPPAVQSTSPPLRPSQPQESMPPLAAAAPFGAPTFWVPGAASGVCVGQPLMIFVVQPSPAALQPSGRPPPPPQGAAPWAACSPAVTAPGLPGQGAILPPGQPETHIPRWPESPSGEGTAPPLEPQPQAPSLPSSTSLLDELLAATGVPDTQAPSPGAAADEGVGPALPGAPSFLDELLAATGTPDTPGPSLGPSADERAHLALPGELLAAAGLPGSPGPSPGSSPVVAGPHPALPGPPSLLEEILAATAIQDTPWSSPGSPAGEEGVEATLETPLSEDEYQALLDMLPGSPGPGA", "length": 472, "header": "tr|A0AAA9S6A2-1|A0AAA9S6A2_BOVIN Isoform 1 of Homeobox domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6A2-1" }, "locus": { "chromosome": "7", "start_pos": 90118, "end_pos": 87070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111847.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111847.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079386.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 88, "start_aa": "Thr", "end_pos": 88, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr88", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A2" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 71, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 88 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6A8-1", "uniprot_ac": "A0AAA9S6A8", "uniprot_id": "A0AAA9S6A8_BOVIN", "mass": { "chemical_mass": 34700.0, "monoisotopic_mass": 34700.0 }, "refseq": { "ac": "NP_001377543", "name": "olfactory receptor family 4 subfamily A member 47AC", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377543" }, "gene_names": [ { "name": "OR4A47AC", "type": "recommended", "evidence": [ { "id": "A0AAA9S6A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8" } ] }, { "name": "OR4A47AC", "type": "synonym", "evidence": [ { "id": "NP_001377543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377543" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 4 subfamily A member 47AC", "type": "synonym", "evidence": [ { "id": "A0AAA9S6A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4A47", "type": "synonym", "evidence": [ { "id": "NP_001377543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377543" } ] }, { "name": "olfactory receptor family 4 subfamily A member 47AC", "type": "synonym", "evidence": [ { "id": "NP_001377543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377543" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377543" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4A47AC", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8", "locus": { "chromosome": "15", "start_pos": 78280688, "end_pos": 78218264, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068128", "url": "https://www.ensembl.org/id/ENSBTAG00000068128" } ] } } ], "crossref": [ { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789201", "url": "https://www.ncbi.nlm.nih.gov/gene/789201", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789201", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789201", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRNNVTYFVLLGLTQNPKEQKVLSVMFLFFYILTLMGDLVIIMNITVSKTLNSPMYFFLASLSFIDVTYSSCITPRMISDLFLGEKIISFESCMTQLYTEHFFGGSEIILLVMAYDCYEAICKPLYSLVIMRQRVCVVLLVVSWVGGFLHSATQLSTVCGLPFCGPNVIDHFMCDTFPLLRLVCTDTYLIGILVLANGGLICTLGFLLLLVSYGVILHSLKNLSQEGRRKALHTWGSHITVVICSSVPSIFVKARPAKTFSIDKSLSVFYTVISPMLNPLIYSLRNSELTNAMKKVWRRNIISHFN", "length": 308, "header": "tr|A0AAA9S6A8-1|A0AAA9S6A8_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily A member 47AC OS=Bos taurus OX=9913 GN=OR4A47AC PE=3 SV=1 CANONICAL=A0AAA9S6A8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8/entry#A0AAA9S6A8-1", "sequence": { "sequence": "MEPRNNVTYFVLLGLTQNPKEQKVLSVMFLFFYILTLMGDLVIIMNITVSKTLNSPMYFFLASLSFIDVTYSSCITPRMISDLFLGEKIISFESCMTQLYTEHFFGGSEIILLVMAYDCYEAICKPLYSLVIMRQRVCVVLLVVSWVGGFLHSATQLSTVCGLPFCGPNVIDHFMCDTFPLLRLVCTDTYLIGILVLANGGLICTLGFLLLLVSYGVILHSLKNLSQEGRRKALHTWGSHITVVICSSVPSIFVKARPAKTFSIDKSLSVFYTVISPMLNPLIYSLRNSELTNAMKKVWRRNIISHFN", "length": 308, "header": "tr|A0AAA9S6A8-1|A0AAA9S6A8_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily A member 47AC OS=Bos taurus OX=9913 GN=OR4A47AC PE=3 SV=1 CANONICAL=A0AAA9S6A8-1" }, "locus": { "chromosome": "15", "start_pos": 78279344, "end_pos": 78278421, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101762.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101762.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077611.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789201", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789201", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6A8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 284, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 224, "end_pos": 226 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6C7-1", "uniprot_ac": "A0AAA9S6C7", "uniprot_id": "A0AAA9S6C7_BOVIN", "mass": { "chemical_mass": 29064.0, "monoisotopic_mass": 29064.0 }, "refseq": { "ac": "XP_002699825", "name": "protein FAM133A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699825" }, "gene_names": [ { "name": "FAM133A", "type": "recommended", "evidence": [ { "id": "A0AAA9S6C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7" } ] }, { "name": "FAM133A", "type": "synonym", "evidence": [ { "id": "XP_002699825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699825" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 133 member A", "type": "synonym", "evidence": [ { "id": "A0AAA9S6C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7/entry#names_and_taxonomy" } ] }, { "name": "protein FAM133A", "type": "synonym", "evidence": [ { "id": "XP_002699825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699825" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM133A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7", "locus": { "chromosome": "X", "start_pos": 42171387, "end_pos": 42118963, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064551", "url": "https://www.ensembl.org/id/ENSBTAG00000064551" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011277", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011277", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540188", "url": "https://www.ncbi.nlm.nih.gov/gene/540188", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540188", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540188", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "G3X6W4", "url": "https://www.orthodb.org/?gene=G3X6W4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31911:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31911:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002699825", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699825", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6W4", "url": "https://www.uniprot.org/uniprotkb/G3X6W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6W4-1", "url": "https://www.uniprot.org/uniprotkb/G3X6W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKWDNRVAYMNPIAMARWRGLSQSAGPTIQDYLNRPRPTWEEVKKQLENKKKGSKALAEFEEKMNENWKKELEKSREKLLSGNESLSKKRDRKKKKKKKSCRSSSSSSLSSDSSSSSPDSEDEEKKEGKKRKKKKNHSYKSSESSPCDSESESKESVKKKKKSKDETEKEKCIRNLSKKRKKTCPEDKPLSLESSSESDYEEEMQTKKKRRREEQEKGTEKAKKKKKKQYKKHSKKKKKKSDSSHKSV", "length": 249, "header": "tr|A0AAA9S6C7-1|A0AAA9S6C7_BOVIN Isoform 1 of Family with sequence similarity 133 member A OS=Bos taurus OX=9913 GN=FAM133A PE=3 SV=1 CANONICAL=A0AAA9S6C7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7/entry#A0AAA9S6C7-1", "sequence": { "sequence": "MGKWDNRVAYMNPIAMARWRGLSQSAGPTIQDYLNRPRPTWEEVKKQLENKKKGSKALAEFEEKMNENWKKELEKSREKLLSGNESLSKKRDRKKKKKKKSCRSSSSSSLSSDSSSSSPDSEDEEKKEGKKRKKKKNHSYKSSESSPCDSESESKESVKKKKKSKDETEKEKCIRNLSKKRKKTCPEDKPLSLESSSESDYEEEMQTKKKRRREEQEKGTEKAKKKKKKQYKKHSKKKKKKSDSSHKSV", "length": 249, "header": "tr|A0AAA9S6C7-1|A0AAA9S6C7_BOVIN Isoform 1 of Family with sequence similarity 133 member A OS=Bos taurus OX=9913 GN=FAM133A PE=3 SV=1 CANONICAL=A0AAA9S6C7-1" }, "locus": { "chromosome": "X", "start_pos": 42169274, "end_pos": 42168528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122954.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122954.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087605.1" } ] } }, { "isoform_ac": "G3X6W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C7/entry#G3X6W4-1", "sequence": { "sequence": "MGKWDNRVAYMNPIAMARWRGLSQSAGPTIQDYLNRPRPTWEEVKKQLENKKKGSKALAEFEEKMNENWKKELEKSREKLLSGNESLSKKRDRKKKKKKKSCRSSSSSSLSSDSSSSSPDSEDEEKKEGKKRKKKKNHSYKSSESSPCDSESESKESVKKKKKSKDETEKEKCIRNLSKKRKKTCPEDKPLSLESSSESDYEEEMQTKKKRRREEQEKGTEKAKKKKKKQYKKHSKKK", "length": 238, "header": "tr|G3X6W4-1|G3X6W4_BOVIN Computationally mapped isoform of Family with sequence similarity 133 member A OS=Bos taurus OX=9913 GN=FAM133A PE=3 SV=2 CANONICAL=A0AAA9S6C7-1" }, "locus": { "chromosome": "X", "start_pos": 42169241, "end_pos": 42168528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014983.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014983.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014983.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014983.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540188", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540188", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6C8-1", "uniprot_ac": "A0AAA9S6C8", "uniprot_id": "A0AAA9S6C8_BOVIN", "mass": { "chemical_mass": 95664.0, "monoisotopic_mass": 95664.0 }, "refseq": { "ac": "XP_010817364", "name": "axin-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817364" }, "gene_names": [ { "name": "AXIN1", "type": "recommended", "evidence": [ { "id": "A0AAA9S6C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ] }, { "name": "AXIN1", "type": "synonym", "evidence": [ { "id": "XP_010817364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817364" } ] } ], "protein_names": [ { "name": "Axin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9S6C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8/entry#names_and_taxonomy" } ] }, { "name": "Axis inhibition protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S6C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8/entry#names_and_taxonomy" } ] }, { "name": "axin-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010817364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817364" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AXIN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8", "locus": { "chromosome": "25", "start_pos": 313099, "end_pos": 353819, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016577", "url": "https://www.ensembl.org/id/ENSBTAG00000016577" } ] } } ], "crossref": [ { "id": "A0AAA9S6C8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6C8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016577", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016577", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08707", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08707", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11582", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11582", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504357", "url": "https://www.ncbi.nlm.nih.gov/gene/504357", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043581", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043581", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504357", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504357", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVYTAST", "url": "https://omabrowser.org/oma/group/YVYTAST/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUL7", "url": "https://www.orthodb.org/?gene=A0A3Q1MUL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B714", "url": "https://www.orthodb.org/?gene=E1B714", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "M5FK80", "url": "https://www.orthodb.org/?gene=M5FK80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46102:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46102:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00778", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00778", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-195253", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-196299", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196299", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201681", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010817364", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817364", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B714", "url": "https://www.uniprot.org/uniprotkb/E1B714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B714-1", "url": "https://www.uniprot.org/uniprotkb/E1B714-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M5FK80", "url": "https://www.uniprot.org/uniprotkb/M5FK80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M5FK80-1", "url": "https://www.uniprot.org/uniprotkb/M5FK80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPVSHSFCSGKGAGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKDCISKQQIDPAMFDQAQTEVQSTMEENTYPSFLKSDIYLEYTRTGSESPKLCSDQSSGSGTGKGVPGYLPTLNEDEEWKCDREVDEDSGRDPAPPGRLTQKLLLETAAPRASSSRRYSEGRELRCGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADSLSLTDSSVDGVPPYRTRRQHRREMQESVQANGRVPLPHIPRTYRMPKEVRVEPQKFAAELIHRLEAVQRTREAEEELEERLKRVRMQEEEGEDSDMPSGPQGASHKLPSAPAWHHFPSRYADVGCTGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSAHVPKIGVLGGAMPGHGKHAPKLGAKLDPTGLHLHRHGHHHGHHGAARPKEPAEAEAARRVPGSFAWGPELHGHAAKPRSHVESTGAPPAGGDGLAYGGKVGTTSKRNSKKAELGKSSSTEAPGPSEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGAKKQQAHESSRPLSIERPGAVHPWVSAQLRSSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRASKAPSKQRYVQEVIQRGRCCVRPACTPVLSAVPAVSDLELSETETKSQRKAGGGSTQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGNYRFYFKKVSDEFECGVVFEEVREDTAVLPVFEEKIIGKVEKVD", "length": 867, "header": "tr|A0AAA9S6C8-1|A0AAA9S6C8_BOVIN Isoform 1 of Axin-1 OS=Bos taurus OX=9913 GN=AXIN1 PE=4 SV=1 CANONICAL=A0AAA9S6C8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8/entry#A0A3Q1MUL7-1", "sequence": { "sequence": "MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPVSHSFCSGKGAGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKDCISKQQIDPAMFDQAQTEVQSTMEENTYPSFLKSDIYLEYTRTGSESPKLCSDQSSGSGTGKGVPGYLPTLNEDEEWKCDREVDEDSGRDPAPPGRLTQKLLLETAAPRASSSRRYSEGRELRCGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADSLSLTDSSVDGVPPYRTRRQHRREMQESVQANGRVPLPHIPRTYRMPKEVRVEPQKFAAELIHRLEAVQRTREAEEELEERLKRVRMQEEEGEDSDMPSGPQGASHKLPSAPAWHHFPSRYADVGCTGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSAHVPKIGVLGGAMPGHGKHAPKLGAKLDPTGLHLHRHGHHHGHHGAARPKEPAEAEAARRVPGSFAWGPELHGHAAKPRSHVESTGAPPAGGDGLAYGGKVGTTSKRNSKKAELGKSSSTEAPGPSEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGAKKQQAHESSRPLSIERPGAVHPWVSAQLRSSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRASKAPSKQRTKSQRKAGGGSTQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGNYRFYFKKVSDEFECGVVFEEVREDTAVLPVFEEKIIGKVEKVD", "length": 831, "header": "tr|A0A3Q1MUL7-1|A0A3Q1MUL7_BOVIN Computationally mapped isoform of Axin-1 OS=Bos taurus OX=9913 GN=AXIN1 PE=4 SV=2 CANONICAL=A0AAA9S6C8-1" }, "locus": { "chromosome": "25", "start_pos": 347209, "end_pos": 313686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084333.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084333.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074294.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074294.2" } ] } }, { "isoform_ac": "A0AAA9S6C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8/entry#A0AAA9S6C8-1", "sequence": { "sequence": "MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPVSHSFCSGKGAGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKDCISKQQIDPAMFDQAQTEVQSTMEENTYPSFLKSDIYLEYTRTGSESPKLCSDQSSGSGTGKGVPGYLPTLNEDEEWKCDREVDEDSGRDPAPPGRLTQKLLLETAAPRASSSRRYSEGRELRCGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADSLSLTDSSVDGVPPYRTRRQHRREMQESVQANGRVPLPHIPRTYRMPKEVRVEPQKFAAELIHRLEAVQRTREAEEELEERLKRVRMQEEEGEDSDMPSGPQGASHKLPSAPAWHHFPSRYADVGCTGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSAHVPKIGVLGGAMPGHGKHAPKLGAKLDPTGLHLHRHGHHHGHHGAARPKEPAEAEAARRVPGSFAWGPELHGHAAKPRSHVESTGAPPAGGDGLAYGGKVGTTSKRNSKKAELGKSSSTEAPGPSEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGAKKQQAHESSRPLSIERPGAVHPWVSAQLRSSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRASKAPSKQRYVQEVIQRGRCCVRPACTPVLSAVPAVSDLELSETETKSQRKAGGGSTQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGNYRFYFKKVSDEFECGVVFEEVREDTAVLPVFEEKIIGKVEKVD", "length": 867, "header": "tr|A0AAA9S6C8-1|A0AAA9S6C8_BOVIN Isoform 1 of Axin-1 OS=Bos taurus OX=9913 GN=AXIN1 PE=4 SV=1 CANONICAL=A0AAA9S6C8-1" }, "locus": { "chromosome": "25", "start_pos": 347209, "end_pos": 313686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132485.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132485.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078848.1" } ] } }, { "isoform_ac": "E1B714-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8/entry#E1B714-1", "sequence": { "sequence": "MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPVSHSFCSGKGAGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKDCISKQQIDPAMFDQAQTEVQSTMEENTYPSFLKSDIYLEYTRTGSESPKLCSDQSSGSGTGKGVPGYLPTLNEDEEWKCDREVDEDSGRDPAPPGRLTQKLLLETAAPRASSSRRYSEGRELRCGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADSLSLTDSSVDGVPPYRTRRQHRREMQESVQANGRVPLPHIPRTYRMPKEVRVEPQKFAAELIHRLEAVQRTREAEEELEERLKRVRMEEEGEDSDMPSGPQGASHKLPSAPAWHHFPSRYADVGCTGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSAHVPKIGVLGGAMPGHGKHAPKLGAKLDPTGLHLHRHGHHHGHHGAARPKEPAEAEAARRVPGSFAWGPELHGHAAKPRSHVESTGAPPAGGDGLAYGGKVGTTSKRNSKKAELGKSSSTEAPGPSEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGAKKQQAHESSRPLSIERPGAVHPWVSAQLRSSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRASKAPSKQRTKSQRKAGGGSTQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGNYRFYFKKVSDEFECGVVFEEVREDTAVLPVFEEKIIGKVEKVD", "length": 830, "header": "tr|E1B714-1|E1B714_BOVIN Computationally mapped isoform of Axin-1 OS=Bos taurus OX=9913 GN=AXIN1 PE=4 SV=2 CANONICAL=A0AAA9S6C8-1" }, "locus": { "chromosome": "25", "start_pos": 347209, "end_pos": 313686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022053.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022053.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022053.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022053.5" } ] } }, { "isoform_ac": "M5FK80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8/entry#M5FK80-1", "sequence": { "sequence": "MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPVSHSFCSGKGAGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKDCISKQQIDPAMFDQAQTEVQSTMEENTYPSFLKSDIYLEYTRTGSESPKLCSDQSSGSGTGKGVPGYLPTLNEDEEWKCDREVDEDSGRDPAPPGRLTQKLLLETAAPRASSSRRYSEGRELRCGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADSLSLTDSSVDGVPPYRTRRQHRREMQESVQANGRVPLPHIPRTYRMPKEVRVEPQKFAAELIHRLEAVQRTREAEEELEERLKRVRMEEEGEDSDMPSGPQGASHKLPSAPAWHHFPSRYADVGCTGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSAHVPKIGVLGGAMPGHGKHAPKLGAKLDPTGLHLHRHGHHHGHHGAARPKEPAEAEAARRVPGSFAWGPELHGHAAKPRSHVESTGAPPAGGDGLAYGGKVGTTSKRNSKKAELGKSSSTEAPGPSEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGAKKQQAHESSRPLSIERPGAVHPWVSAQLRSSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRASKAPSKQRYVQEVIQRGRCCVRPACTPVLSAVPAVSDLELSETETKSQRKAGGGSTQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGNYRFYFKKVSDEFECGVVFEEVREDTAVLPVFEEKIIGKVEKVD", "length": 866, "header": "tr|M5FK80-1|M5FK80_BOVIN Computationally mapped isoform of Axin-1 OS=Bos taurus OX=9913 GN=AXIN1 PE=4 SV=1 CANONICAL=A0AAA9S6C8-1" }, "locus": { "chromosome": "25", "start_pos": 347209, "end_pos": 313686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087508.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087508.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067751.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067751.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 79, "start_aa": "Thr", "end_pos": 79, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr79", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504357", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504357", "resource": "KEGG Pathway" }, { "id": "R-BTA-195253", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-BTA-196299", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196299", "resource": "Reactome", "description": "Beta-catenin phosphorylation cascade" }, { "id": "R-BTA-201681", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201681", "resource": "Reactome", "description": "TCF dependent signaling in response to WNT" }, { "id": "R-BTA-4641257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-BTA-4641262", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "resource": "Reactome", "description": "Disassembly of the destruction complex and recruitment of AXIN to the membrane" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P395-1", "protein_name": "Axin-1", "gene_name": "AXIN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNIQGKGFPLDLGGSFTEDAPRPPVPGEEGELVSTDPRPVSHGFYSSKSDAVRNETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFACSGFRKLEPCVSNEEKRLKLAKAIYKKYILDNNGIVSRQIKPATKSFIKDCVMKLQIDPDMFDQAQTEIQCMIEDNTYPLFLKSDIYLEYTRTGGESPKIYSDPSSGSGTGKGLPGYLPTLNEDEEWKCDQDTEPEASRDSAPSSRLTQKLLLETATQRATSTRRYSEGREFRHGSWREPVNPYYVNTGYAMAPATSANDSEQQSMSSDADTMSLTDSSIDGIPPYRLRKQHRREMQESAKANGRVPLPHIPRTYRMPKDIHVEPEKFAAELINRLEEVQKEREAEEKLEERLKRVRAEEEGEDADISSGPSVISHKMPSAQPFHHFAPRYSEMGCAGMQMRDAHEENPESILDEHVQRVMKTPGCQSPGPGRHSPKPRSPESGHLGKLSGTLGTIPPGHGKHTTKSGMKLDAANLYHHKHVYHHIHHHSMMKPKEQIEAEATQRVQNSFAWNVDSHNYATKSRNYSENLGMAPVPMDSLGYSGKASLLSKRNIKKTDSGKSDGANYEMPGSPEDVERNQKILQWIIEGEKEISRHKKTNHGSSGAKKQLSHDMVRPLSIERPVAVHPWVSAQLRNVVQPSHPFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRAGKLPLKQRLKPQKRPGSGASQPCENIVVAYYFCGEPIPYRTLVKGRVVTLGQFKELLTKKGNYRYYFKKVSDEFDCGVVFEEVREDDTILPIFEEKIIGKVEKID", "length": 841 }, "evidence": [ { "id": "A0AAA9S6C8", "url": "https://omabrowser.org/oma/group/A0AAA9S6C8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A5G2RK10-1", "protein_name": "Axin-1", "gene_name": "AXIN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNTQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPVSHSFCSGKGAGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLRQEHCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRRYILDSGGVVSRQTKPATKSFIKDCIAKQQIDPAMFDQAQTEVQSSMEANTYPAFLKSDIYAECTRAGAESPKACGEPGSAAGTGKGVPGYLPTLNEDEEWTCDRGADEEAAGDPAPPGRLTQTLLLLETAAPRACSSRRYSEGREFRHGSWREPVHSYYVNSGYALAPATSANDSEQQSLSSDADSLSLTDSSVDGIPPYRARKQHRREMQESLQVNGRGPLPHIPRTYRMPKEVRVEPQKFAAELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEGGDVSSAPPGASHKLPAAPAWHHFPARYADVGCVGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPENSHMPKIGVLGAAVPGHGKHAPKLGVKLDAAGLHLHRHSHHHGHHGAARPKEPAEAEASRRVQSSFAWGPELHGHAAKPRSHLESLGTPLNTGDSLAYSGKAGMTSKRSAKKAESGRSASAEAPGPSEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGAKKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRASKVPSKQRYVQGVIQRGRSCARPACTPVLSMVPAVSDLELSEAETKSQRKAGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGNYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD", "length": 867 }, "evidence": [ { "id": "A0AAA9S6C8", "url": "https://omabrowser.org/oma/group/A0AAA9S6C8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15169-1", "protein_name": "Axin-1", "gene_name": "AXIN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD", "length": 862 }, "evidence": [ { "id": "A0AAA9S6C8", "url": "https://omabrowser.org/oma/group/A0AAA9S6C8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35625-1", "protein_name": "Axin-1", "gene_name": "Axin1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESIQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAVLGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEAEVARRVQSSFSWGPETHGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGLRKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRYVQAVMQRGRTCVRPACAPVLSVVPAVSDLELSETETKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD", "length": 863 }, "evidence": [ { "id": "A0AAA9S6C8", "url": "https://omabrowser.org/oma/group/A0AAA9S6C8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O70239-1", "protein_name": "Axin-1", "gene_name": "Axin1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDSVPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAVLGGTASGHGKHAPKLGLKLDSAGLHHHRHVHHHVHHNSARPKEQMEAEAARRVQSSFSWGPETHGHAKPRSYSESTGTNPSAGDLAFGGKASAPSKRNTKKAESGKNASAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGMRKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRTKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAILPVFEEKIIGKVEKVD", "length": 827 }, "evidence": [ { "id": "A0AAA9S6C8", "url": "https://omabrowser.org/oma/group/A0AAA9S6C8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9V407-1", "protein_name": "Axin", "gene_name": "Axn", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSGHPSGIRKHDDNECSGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIYRFLRKSQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGSGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRSRRYAQPPMQHLSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETIVVFSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD", "length": 745 }, "evidence": [ { "id": "A0AAA9S6C8", "url": "https://omabrowser.org/oma/group/A0AAA9S6C8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "lateral plasma membrane", "id": "GO:0016328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016328", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "beta-catenin destruction complex", "id": "GO:0030877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030877", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "Wnt signalosome", "id": "GO:1990909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 15, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "R-SMAD binding", "id": "GO:0070412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "I-SMAD binding", "id": "GO:0070411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "beta-catenin destruction complex assembly", "id": "GO:1904885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904885", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" }, { "name": "cell development", "id": "GO:0048468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" }, { "id": "PS50841", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50841" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DIX", "eco_id": "ECO_0000259", "start_pos": 785, "end_pos": 867, "start_aa": "Cys", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C8" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 211, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 79 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 319, "end_pos": 321 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6E4-1", "uniprot_ac": "A0AAA9S6E4", "uniprot_id": "A0AAA9S6E4_BOVIN", "mass": { "chemical_mass": 8916.0, "monoisotopic_mass": 8916.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S6E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TTNTKRW", "url": "https://omabrowser.org/oma/group/TTNTKRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PF27987", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27987", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKVTDQSWEPKTTSTKRWKKRKTLSQPGSRGKVVKIYKKVKRPLHVCSRKKYSPKVITTRRQRRTRRAKLQPVP", "length": 75, "header": "tr|A0AAA9S6E4-1|A0AAA9S6E4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6E4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E4/entry#A0AAA9S6E4-1", "sequence": { "sequence": "MAKVTDQSWEPKTTSTKRWKKRKTLSQPGSRGKVVKIYKKVKRPLHVCSRKKYSPKVITTRRQRRTRRAKLQPVP", "length": 75, "header": "tr|A0AAA9S6E4-1|A0AAA9S6E4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6E4-1" }, "locus": { "chromosome": "4", "start_pos": 43571606, "end_pos": 43571206, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130342.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130342.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079450.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q7M2P1-1", "protein_name": "Spermatid nuclear transition protein 3", "gene_name": "TNP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "AKVTEKSWQPQTTSTKRWKKRKTPSQPRSRGKVRKIYKKVKRPLHVCSRKKYSPKVITTSRRQKRARRANKFETIP", "length": 76 }, "evidence": [ { "id": "A0AAA9S6E4", "url": "https://omabrowser.org/oma/group/A0AAA9S6E4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6F0-1", "uniprot_ac": "A0AAA9S6F0", "uniprot_id": "A0AAA9S6F0_BOVIN", "mass": { "chemical_mass": 35393.0, "monoisotopic_mass": 35393.0 }, "refseq": { "ac": "NP_001376840", "name": "olfactory receptor family 2 subfamily AT member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376840" }, "gene_names": [ { "name": "OR2AT2", "type": "recommended", "evidence": [ { "id": "A0AAA9S6F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0" } ] }, { "name": "OR2AT2", "type": "synonym", "evidence": [ { "id": "NP_001376840", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376840" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S6F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2AT4", "type": "synonym", "evidence": [ { "id": "NP_001376840", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376840" } ] }, { "name": "olfactory receptor family 2 subfamily AT member 2", "type": "synonym", "evidence": [ { "id": "NP_001376840", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376840" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376840" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2AT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0", "locus": { "chromosome": "15", "start_pos": 54345985, "end_pos": 54346950, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063456", "url": "https://www.ensembl.org/id/ENSBTAG00000063456" } ] } } ], "crossref": [ { "id": "A0AAA9S6F0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6F0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd13954", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13954", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512627", "url": "https://www.ncbi.nlm.nih.gov/gene/512627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512627", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512627", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242:SF253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242:SF253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376840", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYATACNGSKDSSPIFYLVGIPSLQDVFFLPVFFIFLSFYLLILVGNALILVAVVIEPRLHKPMYFFLINLSALDILFTTTTVPKMLSLLLPGDHYLSFSACFLQIYLFHSFSCSEAFILVVMAYDRYVAICRPLHYPVLMTPQTNAALAASAWLTALLLPIPAVVQTSHMAFDSTVYIYNCFCDHLAVVQASCSDTSPQTLMGFCIAMVMSFLPLLLVLLSYAHILASVLRIGSREGRSKAFSTCSSHLLAVGTYYSSIAIAYVAYRADLPLDFHIVGTVVFAILTPVLNPLIYTLRNKDVKAAITKISCPQDLGPSEDL", "length": 321, "header": "tr|A0AAA9S6F0-1|A0AAA9S6F0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2AT2 PE=3 SV=1 CANONICAL=A0AAA9S6F0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0/entry#A0AAA9S6F0-1", "sequence": { "sequence": "MYATACNGSKDSSPIFYLVGIPSLQDVFFLPVFFIFLSFYLLILVGNALILVAVVIEPRLHKPMYFFLINLSALDILFTTTTVPKMLSLLLPGDHYLSFSACFLQIYLFHSFSCSEAFILVVMAYDRYVAICRPLHYPVLMTPQTNAALAASAWLTALLLPIPAVVQTSHMAFDSTVYIYNCFCDHLAVVQASCSDTSPQTLMGFCIAMVMSFLPLLLVLLSYAHILASVLRIGSREGRSKAFSTCSSHLLAVGTYYSSIAIAYVAYRADLPLDFHIVGTVVFAILTPVLNPLIYTLRNKDVKAAITKISCPQDLGPSEDL", "length": 321, "header": "tr|A0AAA9S6F0-1|A0AAA9S6F0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2AT2 PE=3 SV=1 CANONICAL=A0AAA9S6F0-1" }, "locus": { "chromosome": "15", "start_pos": 54346950, "end_pos": 54345988, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132545.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132545.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077732.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512627", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512627", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 295, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 70, "end_pos": 72 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6G0-1", "uniprot_ac": "A0AAA9S6G0", "uniprot_id": "A0AAA9S6G0_BOVIN", "mass": { "chemical_mass": 35761.0, "monoisotopic_mass": 35761.0 }, "refseq": {}, "gene_names": [ { "name": "LOC789275", "type": "recommended", "evidence": [ { "id": "A0AAA9S6G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0" } ] } ], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S6G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC789275", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6G0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6G0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAILRLNYTSVTEFILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMATIWKEDSLHTPMYLFLCALSISEVLYTFAIIPRMLADLLSTDRSISFTACASQMFFSFTPGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVAWSWVGGLVVGLVVTSSIFQLTFCGSNEIHYFGCHVPPLLKLACGTEVQVVAKGVGLVCIAALLGCGLLILLSYAFIVAAILRIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPQSLEGDTLMGITYTVLTPFLSPIIFSLRNKELKDRHEEDLPQQFPSFTVIFLQ", "length": 322, "header": "tr|A0AAA9S6G0-1|A0AAA9S6G0_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC789275 PE=3 SV=1 CANONICAL=A0AAA9S6G0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0/entry#A0AAA9S6G0-1", "sequence": { "sequence": "MAAILRLNYTSVTEFILIGFSTFPHLQLMFFLLFLLMYLFTLLGNLLIMATIWKEDSLHTPMYLFLCALSISEVLYTFAIIPRMLADLLSTDRSISFTACASQMFFSFTPGFTHSFLLTVMGYDRYVAICHPLRYNVLMSPRGCACLVAWSWVGGLVVGLVVTSSIFQLTFCGSNEIHYFGCHVPPLLKLACGTEVQVVAKGVGLVCIAALLGCGLLILLSYAFIVAAILRIPSAEGRHKAFSTCASHLTVVVVHYGFASVIYLKPKGPQSLEGDTLMGITYTVLTPFLSPIIFSLRNKELKDRHEEDLPQQFPSFTVIFLQ", "length": 322, "header": "tr|A0AAA9S6G0-1|A0AAA9S6G0_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC789275 PE=3 SV=1 CANONICAL=A0AAA9S6G0-1" }, "locus": { "chromosome": "7", "start_pos": 7045668, "end_pos": 7043986, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118091.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118091.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081573.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6G0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 294, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6H3-1", "uniprot_ac": "A0AAA9S6H3", "uniprot_id": "A0AAA9S6H3_BOVIN", "mass": { "chemical_mass": 25647.0, "monoisotopic_mass": 25647.0 }, "refseq": { "ac": "XP_024840385", "name": "stAR-related lipid transfer protein 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840385" }, "gene_names": [ { "name": "STARD6", "type": "recommended", "evidence": [ { "id": "A0AAA9S6H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3" } ] }, { "name": "STARD6", "type": "synonym", "evidence": [ { "id": "XP_024840385", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840385" } ] } ], "protein_names": [ { "name": "StAR related lipid transfer domain containing 6", "type": "synonym", "evidence": [ { "id": "A0AAA9S6H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3/entry#names_and_taxonomy" } ] }, { "name": "stAR-related lipid transfer protein 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024840385", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840385" } ] } ], "function": [ { "annotation": "May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.", "evidence": [ { "database": "UniProtKB", "id": "E1BJG1", "url": "https://www.uniprot.org/uniprotkb/E1BJG1#function" }, { "database": "UniProtKB", "id": "ARBA00024750", "url": "https://www.uniprot.org/uniprotkb/ARBA00024750#function" }, { "database": "UniProtKB", "id": "A0AAA9S6H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3#function" }, { "database": "UniProtKB", "id": "A0AAA9TPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STARD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3", "locus": { "chromosome": "24", "start_pos": 53723254, "end_pos": 53741784, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008168", "url": "https://www.ensembl.org/id/ENSBTAG00000008168" } ] } } ], "crossref": [ { "id": "A0AAA9S6H3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6H3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008168", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008168", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532195", "url": "https://www.ncbi.nlm.nih.gov/gene/532195", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043556", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043556", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532195", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532195", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YEGNMDI", "url": "https://omabrowser.org/oma/group/YEGNMDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJG1", "url": "https://www.orthodb.org/?gene=E1BJG1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46374", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46374", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46374:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46374:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196108", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196108", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024840385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840385", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJG1", "url": "https://www.uniprot.org/uniprotkb/E1BJG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJG1-1", "url": "https://www.uniprot.org/uniprotkb/E1BJG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDYKALAQQTAQEILGYYQDTSGWKVVKNSKKITVSSKASKKFHGNLYRVEAMIPESTSKLSDFLFKPENRVTWDKSLKMYNMVLKIDLDTFLCHTITESFAMGSISPRDFINLVSVKHYEGNMDVISSTSVDFPAYPPSSSYIRGYNHACGYICLPVQENPAYSKLVMFVQTEMRGKLAPSIIETTMPSNLVSFMINVKDGIKTQKIPSRRGYHHNGHSSFLKKK", "length": 226, "header": "tr|A0AAA9S6H3-1|A0AAA9S6H3_BOVIN Isoform 1 of StAR related lipid transfer domain containing 6 OS=Bos taurus OX=9913 GN=STARD6 PE=4 SV=1 CANONICAL=A0AAA9S6H3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3/entry#A0AAA9S6H3-1", "sequence": { "sequence": "MDYKALAQQTAQEILGYYQDTSGWKVVKNSKKITVSSKASKKFHGNLYRVEAMIPESTSKLSDFLFKPENRVTWDKSLKMYNMVLKIDLDTFLCHTITESFAMGSISPRDFINLVSVKHYEGNMDVISSTSVDFPAYPPSSSYIRGYNHACGYICLPVQENPAYSKLVMFVQTEMRGKLAPSIIETTMPSNLVSFMINVKDGIKTQKIPSRRGYHHNGHSSFLKKK", "length": 226, "header": "tr|A0AAA9S6H3-1|A0AAA9S6H3_BOVIN Isoform 1 of StAR related lipid transfer domain containing 6 OS=Bos taurus OX=9913 GN=STARD6 PE=4 SV=1 CANONICAL=A0AAA9S6H3-1" }, "locus": { "chromosome": "24", "start_pos": 53741045, "end_pos": 53724316, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079494.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079494.1" } ] } }, { "isoform_ac": "A0AAA9TPL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3/entry#A0AAA9TPL5-1", "sequence": { "sequence": "MDYKALAQQTAQEILGYYQDTSGWKVVKNSKKITVSSKASKKFHGNLYRVEAMIPESTSKLSDFLFKPENRVTWDKSLKMYNMVLKIDLDTFLCHTITESFAMGSISPRDFINLVSVKHYEGNMDVISSTSVDFPAYPPSSSYIRGYNHACGYICLPVQENPAYSKLVMFVQTEMRGKLAPSIIETTMPSNLRNSTLLPGTAVIV", "length": 205, "header": "tr|A0AAA9TPL5-1|A0AAA9TPL5_BOVIN Computationally mapped isoform of StAR related lipid transfer domain containing 6 OS=Bos taurus OX=9913 GN=STARD6 PE=4 SV=1 CANONICAL=A0AAA9S6H3-1" }, "locus": { "chromosome": "24", "start_pos": 53741045, "end_pos": 53723586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098312.1" } ] } }, { "isoform_ac": "E1BJG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3/entry#E1BJG1-1", "sequence": { "sequence": "MDYKALAQQTAQEILGYYQDTSGWKVVKNSLIICGFLFLFEKKITVSSKASKKFHGNLYRVEAMIPESTSKLSDFLFKPENRVTWDKSLKMYNMVLKIDLDTFLCHTITESFAMGSISPRDFINLVSVKHYEGNMDVISSTSVDFPAYPPSSSYIRGYNHACGYICLPVQENPAYSKLVMFVQTEMRGKLAPSIIETTMPSNLVSFMINVKDGIKTQKIPSRRGYHHNGHSSFLKKK", "length": 237, "header": "tr|E1BJG1-1|A0AAA9S6H3_BOVIN Computationally mapped isoform of StAR related lipid transfer domain containing 6 OS=Bos taurus OX=9913 GN=STARD6 PE=4 SV=2 CANONICAL=A0AAA9S6H3-1" }, "locus": { "chromosome": "24", "start_pos": 53741045, "end_pos": 53724316, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010736.4", "url": "https://www.ensembl.org/id/ENSBTAT00000010736.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010736.3", "url": "https://www.ensembl.org/id/ENSBTAP00000010736.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532195", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532195", "resource": "KEGG Pathway" }, { "id": "R-BTA-196108", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196108", "resource": "Reactome", "description": "Pregnenolone biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JVS5-1", "protein_name": "StAR-related lipid transfer domain containing 6", "gene_name": "Stard6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDYKAIAQQSAEQVLAYNQDLSGWKVVKTSDFYFPFEKKVTVSSKASKLFQGNLYRIEGVIPELPAHLSDFLYKSEHRVSWDKSLKAFNMIHKIDSDTLICHTITQSFAMGSISPRDFIDLVHIKHQDGNMDIISTRSVEFPGYPPTSHYIRGYNHPSGYVCSPLKENPAYSKLVVFVQTEMKGKLLASVIEKSMPSNLVSFFLNVKDGLKIHKAPIPALRSHHSMHSAVHKKK", "length": 234 }, "evidence": [ { "id": "A0AAA9S6H3", "url": "https://omabrowser.org/oma/group/A0AAA9S6H3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S1Z6-1", "protein_name": "StAR related lipid transfer domain containing 6", "gene_name": "STARD6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDYKALAQQTAQEILGYYQDTSGWKLNKTSKKITVASKASKKFHGNLYRVEGVIPESTSKLSDFLCKPENRVTWDKSLKVCNMVQKIDSDMFICHTITQSFAMGSISPRDFIDLVYLKHYEGNMDVIISTSVNFPGCPPSSSYIRGYNHCCGYICSPLQENPAHSKLVMFVQTEMRGKLAPSVIEATMPSNLVSFILNVKDGLKTHKIPSGSGYHHNGHSSFLNKK", "length": 226 }, "evidence": [ { "id": "A0AAA9S6H3", "url": "https://omabrowser.org/oma/group/A0AAA9S6H3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P59095-1", "protein_name": "StAR-related lipid transfer protein 6", "gene_name": "STARD6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAKLSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS", "length": 220 }, "evidence": [ { "id": "A0AAA9S6H3", "url": "https://omabrowser.org/oma/group/A0AAA9S6H3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P59096-1", "protein_name": "StAR-related lipid transfer protein 6", "gene_name": "Stard6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDYKAIAQQTAEQVLAYNQDLSGWKLIKSSKKVTVSSKTSRIFHGNLYRVEGIIPESAAHLSDFLFKHDHRVSWDKSLKGFNVIHKIDSDTLICHTITQSFAMGSISPRDFIDLVHIKHYERNVDIISTKSVDFPGYAPTSTYIRGFNHPSGYVCSPLKENPAYSKLVIFVQTEMKGKLPASVIEKSMPSNLVSFLLNVKDGVKTYRIPPIRARHSSHSSVHKKKEGHSAIKP", "length": 233 }, "evidence": [ { "id": "A0AAA9S6H3", "url": "https://omabrowser.org/oma/group/A0AAA9S6H3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H3" }, { "id": "PS50848", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "START", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 208, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6J3-1", "uniprot_ac": "A0AAA9S6J3", "uniprot_id": "A0AAA9S6J3_BOVIN", "mass": { "chemical_mass": 26853.0, "monoisotopic_mass": 26853.0 }, "refseq": {}, "gene_names": [ { "name": "EVI2A", "type": "recommended", "evidence": [ { "id": "A0AAA9S6J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3" } ] } ], "protein_names": [ { "name": "Ecotropic viral integration site 2A", "type": "synonym", "evidence": [ { "id": "A0AAA9S6J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EVI2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3", "locus": { "chromosome": "19", "start_pos": 18671438, "end_pos": 18662226, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009354", "url": "https://www.ensembl.org/id/ENSBTAG00000009354" } ] } } ], "crossref": [ { "id": "A0AAA9S6J3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6J3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15568", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15568", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15568:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15568:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R2X7", "url": "https://www.uniprot.org/uniprotkb/F6R2X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R2X7-1", "url": "https://www.uniprot.org/uniprotkb/F6R2X7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MITSTLTDMGHMRHYLHLAFLMTTAFSLSPGTKANYTHLWDNNSTVLDPDIHNKTDRSQNENFNANPKTPEADKKDNSTNMPETETSSHITFLTPKSELELYVSSVVRNSPPTVQNIENTSKSHSEIFKKGVCEEDNNKMAMLVCLIIIAVLFLICTILFLSTVVLANKVSSLRRSKQAGKRQPRSNGDFLASSGLWPAESDTWKRAKQLTVPNLMMQSTGVLTATMERKDEEGTEKLTN", "length": 240, "header": "tr|A0AAA9S6J3-1|A0AAA9S6J3_BOVIN Isoform 1 of Ecotropic viral integration site 2A OS=Bos taurus OX=9913 GN=EVI2A PE=4 SV=1 CANONICAL=A0AAA9S6J3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3/entry#A0AAA9S6J3-1", "sequence": { "sequence": "MITSTLTDMGHMRHYLHLAFLMTTAFSLSPGTKANYTHLWDNNSTVLDPDIHNKTDRSQNENFNANPKTPEADKKDNSTNMPETETSSHITFLTPKSELELYVSSVVRNSPPTVQNIENTSKSHSEIFKKGVCEEDNNKMAMLVCLIIIAVLFLICTILFLSTVVLANKVSSLRRSKQAGKRQPRSNGDFLASSGLWPAESDTWKRAKQLTVPNLMMQSTGVLTATMERKDEEGTEKLTN", "length": 240, "header": "tr|A0AAA9S6J3-1|A0AAA9S6J3_BOVIN Isoform 1 of Ecotropic viral integration site 2A OS=Bos taurus OX=9913 GN=EVI2A PE=4 SV=1 CANONICAL=A0AAA9S6J3-1" }, "locus": { "chromosome": "19", "start_pos": 18670767, "end_pos": 18669667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088614.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088614.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078900.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078900.1" } ] } }, { "isoform_ac": "F6R2X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3/entry#F6R2X7-1", "sequence": { "sequence": "MASHSWCMKITSTLTDMGHMRHYLHLAFLMTTAFSLSPGTKANYTHLWDNNSTVLDPDIHNKTDRSQNENFNANPKTPEADKKDNSTNMPETETSSHITFLTPKSELELYVSSVVRNSPPTVQNIENTSKSHSEIFKKGVCEEDNNKMAMLVCLIIIAVLFLICTILFLSTVVLANKVSSLRRSKQAGKRQPRSNGDFLASSGLWPAESDTWKRAKQLTVPNLMMQSTGVLTATMERKDEEGTEKLTN", "length": 248, "header": "tr|F6R2X7-1|F6R2X7_BOVIN Computationally mapped isoform of Ecotropic viral integration site 2A OS=Bos taurus OX=9913 GN=EVI2A PE=4 SV=1 CANONICAL=A0AAA9S6J3-1" }, "locus": { "chromosome": "19", "start_pos": 18670767, "end_pos": 18663627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012311.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012311.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012311.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012311.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 35, "end_pos": 37 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9M8-1", "uniprot_ac": "A0AAA9S9M8", "uniprot_id": "A0AAA9S9M8_BOVIN", "mass": { "chemical_mass": 124598.0, "monoisotopic_mass": 124598.0 }, "refseq": { "ac": "XP_024846842", "name": "anillin isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846842" }, "gene_names": [ { "name": "ANLN", "type": "recommended", "evidence": [ { "id": "A0AAA9S9M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ] }, { "name": "ANLN", "type": "synonym", "evidence": [ { "id": "XP_024846842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846842" } ] } ], "protein_names": [ { "name": "Anillin", "type": "recommended", "evidence": [ { "id": "A0AAA9S9M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8/entry#names_and_taxonomy" } ] }, { "name": "anillin isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024846842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846842" } ] } ], "function": [ { "annotation": "Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.", "evidence": [ { "database": "UniProtKB", "id": "F1MBT6", "url": "https://www.uniprot.org/uniprotkb/F1MBT6#function" }, { "database": "UniProtKB", "id": "ARBA00057106", "url": "https://www.uniprot.org/uniprotkb/ARBA00057106#function" }, { "database": "UniProtKB", "id": "A0AAA9S6J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J6#function" }, { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8#function" }, { "database": "UniProtKB", "id": "A0AAA9T689", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T689#function" }, { "database": "UniProtKB", "id": "A0AAA9TW78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW78#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANLN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8", "locus": { "chromosome": "4", "start_pos": 60771367, "end_pos": 60831721, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009218", "url": "https://www.ensembl.org/id/ENSBTAG00000009218" } ] } } ], "crossref": [ { "id": "A0AAA9S9M8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9M8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009218", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009218", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518274", "url": "https://www.ncbi.nlm.nih.gov/gene/518274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037840", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037840", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MBT6", "url": "https://www.orthodb.org/?gene=F1MBT6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21538", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21538", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21538:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21538:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024846842", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846842", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T689", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T689", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T689-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T689-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBT6", "url": "https://www.uniprot.org/uniprotkb/F1MBT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBT6-1", "url": "https://www.uniprot.org/uniprotkb/F1MBT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPFTEKLLERTRARRENLQRKMAERPIPAARSLTHAKRIREPLSEASNQQPLSDGEEKSCTKPSPSKKRCSDNTEVEVSDVENEKPVESTSAKPCSPRPVSPQAQPQMSQAPAGVSDSLAAPASAPLLGVRSGPNSRLGAAAASSVRTRMQKLAEQRRCWDSDDVTDDIPESSPISAMPSEEKAASPPKPSLSDASATPVGRRGRLANLAATICSWEDDVKTSSAKQNSVQEQPGTTCLSKFSSASGASARINSSSVKQEATCCSQRDGDASLNKASSSSAVGASLINVAISSPGKATSSPVKSSTTSITSAKNCKVQNPELLQKTSVSPLKTEVSKPVEKSAVSRTVRPKEELNREICLRSQPKDKSATPGGSGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFRQNASSSTTHLAQQLKQERQKELACLRSRFDKGNLWSAEKGENSKSKQLETKQEIHCQSTPLKKQVDPSTPSLTVTEKVTENQTPANPSSRETSDFIECEMTKSSPLKITLFLEEDKSLKVTSEPKVEQQTEVVREIEMSVDDDDDINSSKVINDIFSDVLEEGGLDVEKNQEELDQADAESSEEQEDALNISSMSLLTPLAQTVGVVSPESLVSSPRWEVKDTSISDESPKPGKFQRTRVPRAESGDSIGSEDHDLPYSIDAYRSQRVKETDRPSIKQVIVRKEDVTSKLEEKKNGFPCQVNIKQKMQELNNEINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRTLLIDELNKLKNEGPQRKNKAGPISQSEFVPSRGSITLSEIRLPLKADFVCSTAQKPDAANYYFLIILKAGAENMVATPLASTSTSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQRKDPSGPDKKKKAYKSKAITPKRLLTSVTTKSTLHSSVMASLNAVRTSNFALVGSYTLTLSSVGNTKFALDRVPFLSPLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRLNLANCTSRQIEPVNREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP", "length": 1130, "header": "tr|A0AAA9S9M8-1|A0AAA9S9M8_BOVIN Isoform 1 of Anillin OS=Bos taurus OX=9913 GN=ANLN PE=4 SV=1 CANONICAL=A0AAA9S9M8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8/entry#A0AAA9S6J6-1", "sequence": { "sequence": "MDPFTEKLLERTRARRENLQRKMAERPIPAARSLTHAKRIREPLSEASNQQPLSDGEEKSCTKPSPSKKRCSDNTEVEVSDVENEKPVESTSAKPCSPRPVSPQAQPQMSQAPAGVSDSLAAPASAPLLGVRSGPNSRLGAAAASSVRTRMQKLAEQRRCWDSDDVTDDIPESSPISAMPSEEKAASPPKPSLSDASATPVGRRGRLANLAATICSWEDDVKTSSAKQNSVQEQPGTTCLSKFSSASGASARINSSSVKQEATCCSQRDGDASLNKASSSSAVGASLINVAISSPGKATSSPVKSSTTSITSAKNCKVQNPELLQKTSVSPLKTEVSKPVEKSAVSRTVRPKEELNREICLRSQPKDKSATPGGSGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFRQNASSSTTHLAQQLKQERQKELACLRSRFDKGNLWSAEKGENSKSKQLETKQEIHCQSTPLKKQVDPSTPSLTVTEKVTENQTPANPSSRETSDFIECEMTKSSPLKITLFLEEDKSLKVTSEPKVEQQTEVVREIEMSVDDDDDINSSKVINDIFSDVLEEGGLDVEKNQEELDQADAESSEEQEDALNISSMSLLTPLAQTVGVVSPESLVSSPRWEVKDTSISDESPKPGKFQRTRVPRAESGDSIGSEDHDLPYSIDAYRSQRVKETDRPSIKQVIVRKEDVTSKLEEKKNGFPCQVNIKQKMQELNNEINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRTLLIDELNKLKNEGPQRKNKAGPISQSEFVPSRGSITLSEIRLPLKADFVCSTAQKPDAANYYFLIILKAGAENMVATPLASTSTSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQRKDPSGPDKKKKAYKSKKSTLHSSVMASLNAVRTSNFALVGSYTLTLSSVGNTKFALDRINYDVKERELLGYMFQEKVPFLSPLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRLNLANCTSRQIEPVNREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP", "length": 1135, "header": "tr|A0AAA9S6J6-1|A0AAA9S9M8_BOVIN Computationally mapped isoform of Anillin OS=Bos taurus OX=9913 GN=ANLN PE=4 SV=1 CANONICAL=A0AAA9S9M8-1" }, "locus": { "chromosome": "4", "start_pos": 60830992, "end_pos": 60772371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077779.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077779.1" } ] } }, { "isoform_ac": "A0AAA9S9M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8/entry#A0AAA9S9M8-1", "sequence": { "sequence": "MDPFTEKLLERTRARRENLQRKMAERPIPAARSLTHAKRIREPLSEASNQQPLSDGEEKSCTKPSPSKKRCSDNTEVEVSDVENEKPVESTSAKPCSPRPVSPQAQPQMSQAPAGVSDSLAAPASAPLLGVRSGPNSRLGAAAASSVRTRMQKLAEQRRCWDSDDVTDDIPESSPISAMPSEEKAASPPKPSLSDASATPVGRRGRLANLAATICSWEDDVKTSSAKQNSVQEQPGTTCLSKFSSASGASARINSSSVKQEATCCSQRDGDASLNKASSSSAVGASLINVAISSPGKATSSPVKSSTTSITSAKNCKVQNPELLQKTSVSPLKTEVSKPVEKSAVSRTVRPKEELNREICLRSQPKDKSATPGGSGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFRQNASSSTTHLAQQLKQERQKELACLRSRFDKGNLWSAEKGENSKSKQLETKQEIHCQSTPLKKQVDPSTPSLTVTEKVTENQTPANPSSRETSDFIECEMTKSSPLKITLFLEEDKSLKVTSEPKVEQQTEVVREIEMSVDDDDDINSSKVINDIFSDVLEEGGLDVEKNQEELDQADAESSEEQEDALNISSMSLLTPLAQTVGVVSPESLVSSPRWEVKDTSISDESPKPGKFQRTRVPRAESGDSIGSEDHDLPYSIDAYRSQRVKETDRPSIKQVIVRKEDVTSKLEEKKNGFPCQVNIKQKMQELNNEINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRTLLIDELNKLKNEGPQRKNKAGPISQSEFVPSRGSITLSEIRLPLKADFVCSTAQKPDAANYYFLIILKAGAENMVATPLASTSTSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQRKDPSGPDKKKKAYKSKAITPKRLLTSVTTKSTLHSSVMASLNAVRTSNFALVGSYTLTLSSVGNTKFALDRVPFLSPLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRLNLANCTSRQIEPVNREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP", "length": 1130, "header": "tr|A0AAA9S9M8-1|A0AAA9S9M8_BOVIN Isoform 1 of Anillin OS=Bos taurus OX=9913 GN=ANLN PE=4 SV=1 CANONICAL=A0AAA9S9M8-1" }, "locus": { "chromosome": "4", "start_pos": 60830992, "end_pos": 60772371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094931.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094931.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082787.1" } ] } }, { "isoform_ac": "A0AAA9T689-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8/entry#A0AAA9T689-1", "sequence": { "sequence": "MDPFTEKLLERTRARRENLQRKMAERPIPAARSLTHAKRIREPLSEASNQQPLSDGEEKSCTKPSPSKKRCSDNTEVEVSDVENEKPVESTSAKPCSPRPVSPQAQPQMSQAPAGVSDSLAAPASAPLLGVRSGPNSRLGAAAASSVRTRMQKLAEQRRCWDSDDVTDDIPESSPISAMPSEEKAASPPKPSLSDASATPVGRRGRLANLAATICSWEDDVKTSSAKQNSVQEQPGTTCLSKFSSASGASARINSSSVKQEATCCSQRDGDASLNKASSSSAVGASLINVAISSPGKATSSPVKSSTTSITSAKNCKVQNPELLQKTSVSPLKTEVSKPVEKSAVSRTVRPKEELNREICLRSQPKDKSATPGGSGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFRQNASSSTTHLAQQLKQERQKELACLRSRFDKGNLWSAEKGENSKSKQLETKQEIHCQSTPLKKQVDPSTPSLTVTEKVTENQTPANPSSRETSDFIECEMTKSSPLKITLFLEEDKSLKVTSEPKVEQQTEVVREIEMSVDDDDDINSSKVINDIFSDVLEEGGLDVEKNQEELDQADAESSEEQEDALNISSMSLLTPLAQTVGVVSPESLVSSPRWEVKDTSISDESPKPGKFQRTRVPRAESGDSIGSEDHDLPYSIDAYRSQRVKETDRPSIKQVIVRKEDVTSKLEEKKNGFPCQVNIKQKMQELNNEINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRTLLIDELNKLKNEGPQRKNKAGPISQSEFVPSRGSITLSEIRLPLKADFVCSTAQKPDAANYYFLIILKAGAENMVATPLASTSTSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQRKDPSGPDKKKKAYKSKAITPKRLLTSVTTKSTLHSSVMASLNAVRTSNFALVGSYTLTLSSVGNTKFALDRINYDVKERELLGYMFQEKVPFLSPLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRLNLANCTSRQIEPVNREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP", "length": 1148, "header": "tr|A0AAA9T689-1|A0AAA9T689_BOVIN Computationally mapped isoform of Anillin OS=Bos taurus OX=9913 GN=ANLN PE=4 SV=1 CANONICAL=A0AAA9S9M8-1" }, "locus": { "chromosome": "4", "start_pos": 60830992, "end_pos": 60772371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092749.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092749.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094284.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094284.1" } ] } }, { "isoform_ac": "A0AAA9TW78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8/entry#A0AAA9TW78-1", "sequence": { "sequence": "MDPFTEKLLERTRARRENLQRKMAERPIPAARSLTHAKRIREPLSEASNQQPLSDGEEKSCTKPSPSKKRCSDNTEVEVSDVENEKPVESTSAKPCSPRPVSPQAQPQMSQAPAGVSDSLAAPASAPLLGVRSGPNSRLGAAAASSVRTRMQKLAEQRRCWDSDDVTDDIPESSPISAMPSEEKAASPPKPSLSDASATPVGRRGRLANLAATICSWEDDVKTSSAKQNSVQEQPGTTCLSKFSSASGASARINSSSVKQEATCCSQRDGDASLNKASSSSAVGASLINVAISSPGKATSSPVKSSTTSITSAKNCKVQNPELLQKTSVSPLKTEVSKPVEKSAVSRTVRPKEELNREICLRSQPKDKSATPGGSGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFRQNASSSTTHLAQQLKQERQKELACLRSRFDKGNLWSAEKGENSKSKQLETKQEIHCQSTPLKKQVDPSTPSLTVTEKVTENQTPANPSSRETSEVVREIEMSVDDDDDINSSKVINDIFSDVLEEGGLDVEKNQEELDQADAESSEEQEDALNISSMSLLTPLAQTVGVVSPESLVSSPRWEVKDTSISDESPKPGKFQRTRVPRAESGDSIGSEDHDLPYSIDAYRSQRVKETDRPSIKQVIVRKEDVTSKLEEKKNGFPCQVNIKQKMQELNNEINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRTLLIDELNKLKNEGPQRKNKAGPISQSEFVPSRGSITLSEIRLPLKADFVCSTAQKPDAANYYFLIILKAGAENMVATPLASTSTSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQRKDPSGPDKKKKAYKSKAITPKRLLTSVTTKSTLHSSVMASLNAVRTSNFALVGSYTLTLSSVGNTKFALDRVPFLSPLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRLNLANCTSRQIEPVNREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP", "length": 1093, "header": "tr|A0AAA9TW78-1|A0AAA9TW78_BOVIN Computationally mapped isoform of Anillin OS=Bos taurus OX=9913 GN=ANLN PE=4 SV=2 CANONICAL=A0AAA9S9M8-1" }, "locus": { "chromosome": "4", "start_pos": 60830992, "end_pos": 60772371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112524.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112524.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101695.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101695.2" } ] } }, { "isoform_ac": "F1MBT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8/entry#F1MBT6-1", "sequence": { "sequence": "MDPFTEKLLERTRARRENLQRKMAERPIPAARSLTHAKRIREPLSEASNQQPLSDGEDDIPESSPISAMPSEEKAASPPKPSLSDASATPVGRRGRLANLAATICSWEDDVKTSSAKQNSVQEQPGTTCLSKFSSASGASARINSSSVKQEATCCSQRDGDASLNKASSSSAVGASLINVAISSPGKATSSPVKSSTTSITSAKNCKVQNPELLQKTSVSPLKTEVSKPVEKSAVSRTVRPKEELNREICLRSQPKDKSATPGGSGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFRQNASSSTTHLAQQLKQERQKELACLRSRFDKGNLWSAEKGENSKSKQLETKQEIHCQSTPLKKQVDPSTPSLTVTEKVTENQTPANPSSRETSDFIECEMTKSSPLKITLFLEEDKSLKVTSEPKVEQQTEVVREIEMSVDDDDDINSSKVINDIFSDVLEEGGLDVEKNQEELDQADAESSEEQEDALNISSMSLLTPLAQTVGVVSPESLVSSPRWEVKDTSISDESPKPGKFQRTRVPRAESGDSIGSEDHDLPYSIDAYRSQRVKETDRPSIKQVIVRKEDVTSKLEEKKNGFPCQVNIKQKMQELNNEINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRTLLIDELNKLKNEGPQRKNKAGPISQSEFVPSRGSITLSEIRLPLKADFVCSTAQKPDAANYYFLIILKAGAENMVATPLASTSTSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQRKDPSGPDKKKKAYKSKAITPKRLLTSVTTKSTLHSSVMASLNAVRTSNFALVGSYTLTLSSVGNTKFALDRVPFLSPLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRLNLANCTSRQIEPVNREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP", "length": 1020, "header": "tr|F1MBT6-1|A0AAA9S9M8_BOVIN Computationally mapped isoform of Anillin OS=Bos taurus OX=9913 GN=ANLN PE=4 SV=4 CANONICAL=A0AAA9S9M8-1" }, "locus": { "chromosome": "4", "start_pos": 60830992, "end_pos": 60772371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046371.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046371.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043678.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043678.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 489, "start_aa": "Thr", "end_pos": 489, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr489", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "bleb", "id": "GO:0032059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "actomyosin contractile ring", "id": "GO:0005826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "podocyte cell migration", "id": "GO:0090521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090521", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "positive regulation of bleb assembly", "id": "GO:1904172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904172", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "actomyosin contractile ring assembly", "id": "GO:0000915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" }, { "name": "septin ring organization", "id": "GO:0031106", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031106", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1042, "end_pos": 1044, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" }, { "start_pos": 610, "end_pos": 612, "annotation": "n_glycosylation_sequon" }, { "start_pos": 987, "end_pos": 989, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 989, "end_pos": 1113, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 489 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1042, "end_pos": 1044 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 501, "end_pos": 503 }, { "start_pos": 567, "end_pos": 569 }, { "start_pos": 610, "end_pos": 612 }, { "start_pos": 987, "end_pos": 989 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6K5-1", "uniprot_ac": "A0AAA9S6K5", "uniprot_id": "A0AAA9S6K5_BOVIN", "mass": { "chemical_mass": 51318.0, "monoisotopic_mass": 51318.0 }, "refseq": { "ac": "XP_002695557", "name": "zinc finger protein 584 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695557" }, "gene_names": [ { "name": "ZNF584", "type": "recommended", "evidence": [ { "id": "A0AAA9S6K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ] }, { "name": "ZNF584", "type": "synonym", "evidence": [ { "id": "XP_002695557", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695557" } ] } ], "protein_names": [ { "name": "Zinc finger protein 584", "type": "synonym", "evidence": [ { "id": "A0AAA9S6K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 584 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002695557", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695557" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF584", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5", "locus": { "chromosome": "18", "start_pos": 65687375, "end_pos": 65679765, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037882", "url": "https://www.ensembl.org/id/ENSBTAG00000037882" } ] } } ], "crossref": [ { "id": "A0AAA9S6K5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6K5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037882", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037882", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531064", "url": "https://www.ncbi.nlm.nih.gov/gene/531064", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531064", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531064", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MN03", "url": "https://www.orthodb.org/?gene=F1MN03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002695557", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695557", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN03", "url": "https://www.uniprot.org/uniprotkb/F1MN03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN03-1", "url": "https://www.uniprot.org/uniprotkb/F1MN03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKEAQGPVTFEDVAVYFSLEEWGLLNLTQKSLYRDVMLENFGLIGSLGCLCRLQDEDALLELGESCRVRLSEKPSLCGTSGQVFPATLGFFQPQAACREGAPRGSPECSEACPPGSAGQRQQGCHAAQTPFRCSDCGQAFLQAFTLLDHLVAHARERPIRGPAGGSSPTENSTLVPHWNAHPGETPHVCNECGRAFSYPSKLRKHQKVHTGIKPFKCAECGKTFNRKDALVLHQRIHTGERPYQCGECGKAFSVLSTLIRHRKVHIGERPYECRQCGKLFKYSHSFALHRRVHTGERPYGCGECRKAYVTRSGLYQHRKVHTGERPYECGLCGKTFTTRSYRNRHQRFHTEERAHECPECGRSFKHGSTLLQHRKVHAAGRPQGAGRQAGSPEPRLAHAQVLSPEGRLGRGAVCKRNPPPTPTGAGALPSGPAAVGPLPVPVTGAVPPLRADSSRGVQSGCSGKPFSPP", "length": 470, "header": "tr|A0AAA9S6K5-1|A0AAA9S6K5_BOVIN Isoform 1 of Zinc finger protein 584 OS=Bos taurus OX=9913 GN=ZNF584 PE=3 SV=1 CANONICAL=A0AAA9S6K5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5/entry#A0AAA9S6K5-1", "sequence": { "sequence": "MAKEAQGPVTFEDVAVYFSLEEWGLLNLTQKSLYRDVMLENFGLIGSLGCLCRLQDEDALLELGESCRVRLSEKPSLCGTSGQVFPATLGFFQPQAACREGAPRGSPECSEACPPGSAGQRQQGCHAAQTPFRCSDCGQAFLQAFTLLDHLVAHARERPIRGPAGGSSPTENSTLVPHWNAHPGETPHVCNECGRAFSYPSKLRKHQKVHTGIKPFKCAECGKTFNRKDALVLHQRIHTGERPYQCGECGKAFSVLSTLIRHRKVHIGERPYECRQCGKLFKYSHSFALHRRVHTGERPYGCGECRKAYVTRSGLYQHRKVHTGERPYECGLCGKTFTTRSYRNRHQRFHTEERAHECPECGRSFKHGSTLLQHRKVHAAGRPQGAGRQAGSPEPRLAHAQVLSPEGRLGRGAVCKRNPPPTPTGAGALPSGPAAVGPLPVPVTGAVPPLRADSSRGVQSGCSGKPFSPP", "length": 470, "header": "tr|A0AAA9S6K5-1|A0AAA9S6K5_BOVIN Isoform 1 of Zinc finger protein 584 OS=Bos taurus OX=9913 GN=ZNF584 PE=3 SV=1 CANONICAL=A0AAA9S6K5-1" }, "locus": { "chromosome": "18", "start_pos": 65686902, "end_pos": 65679964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112900.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112900.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077789.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077789.1" } ] } }, { "isoform_ac": "F1MN03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5/entry#F1MN03-1", "sequence": { "sequence": "MAKEAQTQWNASLQGPVTFEDVAVYFSLEEWGLLNLTQKSLYRDVMLENFGLIGSLGFAPSRSSKVAQMEGEGEAWVPNMVDSVVSRAEARKGSRLSCLCRLQDEDALLELGESCRVLQPQAACREGAPRGSPECSEACPPGSAGQRQQGCHAAQTPFRCSDCGQAFLQAFTLLDHLVAHARERPIRGPAGGSSPTENSTLVPHWNAHPGETPHVCNECGRAFSYPSKLRKHQKVHTGIKPFKCAECGKTFNRKDALVLHQRIHTGERPYQCGECGKAFSVLSTLIRHRKVHIGERPYECRQCGKLFKYSHSFALHRRVHTGERPYGCGECRKAYVTRSGLYQHRKVHTGERPYECGLCGKTFTTRSYRNRHQRFHTEERAHECPECGRSFKHGSTLLQHRKVHAAGRPQGAAGRQAALSRGW", "length": 423, "header": "tr|F1MN03-1|A0AAA9S6K5_BOVIN Computationally mapped isoform of Zinc finger protein 584 OS=Bos taurus OX=9913 GN=ZNF584 PE=3 SV=3 CANONICAL=A0AAA9S6K5-1" }, "locus": { "chromosome": "18", "start_pos": 65686684, "end_pos": 65679964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054145.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054145.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049904.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049904.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 422, "start_aa": "Thr", "end_pos": 422, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr422", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 424, "start_aa": "Thr", "end_pos": 424, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr424", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531064", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531064", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 159, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6K5" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 82, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 422, 424 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 27, "end_pos": 29 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6L4-1", "uniprot_ac": "A0AAA9S6L4", "uniprot_id": "A0AAA9S6L4_BOVIN", "mass": { "chemical_mass": 2317.0, "monoisotopic_mass": 2317.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S6L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6L4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6L4", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9S6L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "EARQFTFGTGTQVRVKLSKY", "length": 20, "header": "tr|A0AAA9S6L4-1|A0AAA9S6L4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6L4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6L4/entry#A0AAA9S6L4-1", "sequence": { "sequence": "EARQFTFGTGTQVRVKLSKY", "length": 20, "header": "tr|A0AAA9S6L4-1|A0AAA9S6L4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6L4-1" }, "locus": { "chromosome": "10", "start_pos": 22337822, "end_pos": 22337763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103725.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103725.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078923.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6M1-1", "uniprot_ac": "A0AAA9S6M1", "uniprot_id": "A0AAA9S6M1_BOVIN", "mass": { "chemical_mass": 11661.0, "monoisotopic_mass": 11661.0 }, "refseq": {}, "gene_names": [ { "name": "BORCS7", "type": "recommended", "evidence": [ { "id": "A0AAA9S6M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1" } ] } ], "protein_names": [ { "name": "BLOC-1-related complex subunit 7", "type": "recommended", "evidence": [ { "id": "A0AAA9S6M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BORCS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1", "locus": { "chromosome": "26", "start_pos": 23496703, "end_pos": 23483985, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061159", "url": "https://www.ensembl.org/id/ENSBTAG00000061159" } ] } } ], "crossref": [ { "id": "A0AAA9S6M1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6M1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR032143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31397", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31397", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31397:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31397:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16088", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16088", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VMATGTPDSQARFGQSVKGLLTEKVNTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSNLQDQLNHLLK", "length": 106, "header": "tr|A0AAA9S6M1-1|A0AAA9S6M1_BOVIN Isoform 1 of BLOC-1-related complex subunit 7 OS=Bos taurus OX=9913 GN=BORCS7 PE=3 SV=1 CANONICAL=A0AAA9S6M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1/entry#A0AAA9S6M1-1", "sequence": { "sequence": "VMATGTPDSQARFGQSVKGLLTEKVNTCGTDVIALTKQVLKGSRSSELLGQAARNMVLQEDAILHSEDSLRKMAIITTHLQYQQEAIQKNVEQSSNLQDQLNHLLK", "length": 106, "header": "tr|A0AAA9S6M1-1|A0AAA9S6M1_BOVIN Isoform 1 of BLOC-1-related complex subunit 7 OS=Bos taurus OX=9913 GN=BORCS7 PE=3 SV=1 CANONICAL=A0AAA9S6M1-1" }, "locus": { "chromosome": "26", "start_pos": 23495868, "end_pos": 23484007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100459.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100459.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081639.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6M8-1", "uniprot_ac": "A0AAA9S6M8", "uniprot_id": "A0AAA9S6M8_BOVIN", "mass": { "chemical_mass": 57726.0, "monoisotopic_mass": 57726.0 }, "refseq": { "ac": "NP_001421899", "name": "7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421899" }, "gene_names": [ { "name": "CYP8B1", "type": "recommended", "evidence": [ { "id": "A0AAA9S6M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ] }, { "name": "CYP8B1", "type": "synonym", "evidence": [ { "id": "NP_001421899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421899" } ] } ], "protein_names": [ { "name": "7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase", "type": "synonym", "evidence": [ { "id": "NP_001421899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421899" } ] }, { "name": "Cytochrome P450 family 8 subfamily B member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S6M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8/entry#names_and_taxonomy" } ] }, { "name": "cytochrome P450, family 8, subfamily B, polypeptide 1", "type": "synonym", "evidence": [ { "id": "NP_001421899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421899" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYP8B1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8", "locus": { "chromosome": "22", "start_pos": 14914988, "end_pos": 14950798, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056462", "url": "https://www.ensembl.org/id/ENSBTAG00000056462" } ] } } ], "crossref": [ { "id": "538964", "url": "https://www.ncbi.nlm.nih.gov/gene/538964", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24306:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24306:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421899", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLWGPALGALLVAIVGYLCLRGLLRQRRPKEPPLDKGPVPWLGHAMAFRKNMFEFLRHMQAKHGDIFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVEYAQKLVLKVFGYRSVQGDYRMIHSASTKHLMGEGLEELNKVMLDTLSLVMLGPIGPSLGTHHWREDGLFHFCYNILFKAGYLSLFGYTKDKEQDLLQAEELFLEFRKYDRLFPRFVYSLLGPREWLEVGRLQRLFHKELSVEHNLEKYGVSNWITYMLQFLREQGVSPAMQDKFNFMMLWASQGNTGPTSFWALLFLLKHPEAMRAVREEATRLLGEVRLEAKQSFKFGALHHMPVLDSVMEETLRLRASPTLLRVVNDDQILQMASGQEYLLRNGDILALFPYLSVHMDPDIHPEPTAFRYDRFLTPSGSRKVDFYKAGKKIRHYTMPWGSGVSICPGRFLALNEMKLFILLMVMNFDLELVDPATPVPPVDPQRWGFGTTQPSHEVRFRYRLRPAE", "length": 499, "header": "tr|A0AAA9S6M8-1|A0AAA9S6M8_BOVIN Isoform 1 of Cytochrome P450 family 8 subfamily B member 1 OS=Bos taurus OX=9913 GN=CYP8B1 PE=3 SV=1 CANONICAL=A0AAA9S6M8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8/entry#A0AAA9S6M8-1", "sequence": { "sequence": "MVLWGPALGALLVAIVGYLCLRGLLRQRRPKEPPLDKGPVPWLGHAMAFRKNMFEFLRHMQAKHGDIFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVEYAQKLVLKVFGYRSVQGDYRMIHSASTKHLMGEGLEELNKVMLDTLSLVMLGPIGPSLGTHHWREDGLFHFCYNILFKAGYLSLFGYTKDKEQDLLQAEELFLEFRKYDRLFPRFVYSLLGPREWLEVGRLQRLFHKELSVEHNLEKYGVSNWITYMLQFLREQGVSPAMQDKFNFMMLWASQGNTGPTSFWALLFLLKHPEAMRAVREEATRLLGEVRLEAKQSFKFGALHHMPVLDSVMEETLRLRASPTLLRVVNDDQILQMASGQEYLLRNGDILALFPYLSVHMDPDIHPEPTAFRYDRFLTPSGSRKVDFYKAGKKIRHYTMPWGSGVSICPGRFLALNEMKLFILLMVMNFDLELVDPATPVPPVDPQRWGFGTTQPSHEVRFRYRLRPAE", "length": 499, "header": "tr|A0AAA9S6M8-1|A0AAA9S6M8_BOVIN Isoform 1 of Cytochrome P450 family 8 subfamily B member 1 OS=Bos taurus OX=9913 GN=CYP8B1 PE=3 SV=1 CANONICAL=A0AAA9S6M8-1" }, "locus": { "chromosome": "22", "start_pos": 14931714, "end_pos": 14931592, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079560.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079560.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "sterol 12-alpha-hydroxylase activity", "id": "GO:0008397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "bile acid biosynthetic process", "id": "GO:0006699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006699", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6M8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6P1-1", "uniprot_ac": "A0AAA9S6P1", "uniprot_id": "A0AAA9S6P1_BOVIN", "mass": { "chemical_mass": 31902.0, "monoisotopic_mass": 31902.0 }, "refseq": {}, "gene_names": [ { "name": "IER5", "type": "recommended", "evidence": [ { "id": "A0AAA9S6P1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ] } ], "protein_names": [ { "name": "Immediate early response 5", "type": "synonym", "evidence": [ { "id": "A0AAA9S6P1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IER5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1", "locus": { "chromosome": "16", "start_pos": 62211289, "end_pos": 62209144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057959", "url": "https://www.ensembl.org/id/ENSBTAG00000057959" } ] } } ], "crossref": [ { "id": "A0AAA9S6P1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6P1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15895", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15895", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05760", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05760", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGHPGAPAPPQQPEESAAGPPAGWGEPPPPAGRAAWPEPEPQPERPAVPEVPRAGDAQPAATVTAAGDTLQGGEAEAPEAAWRRVEGPRETAIGGAGGPAEVSGVFPQGPEDRLSAAPRVDGCRAPRPAAAEPPASPPVCARKRGAAGVGGGPADCPAPGSTPLKKPRRNSEEQPGGAAAAAEEEEEMETGNVANLISIFGSSFSGLLRKSPGGGREEAEGEESGPEAAEPGQICCDKPVLRDINPWSTAIVAF", "length": 311, "header": "tr|A0AAA9S6P1-1|A0AAA9S6P1_BOVIN Isoform 1 of Immediate early response 5 OS=Bos taurus OX=9913 GN=IER5 PE=3 SV=1 CANONICAL=A0AAA9S6P1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1/entry#A0AAA9S6P1-1", "sequence": { "sequence": "MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGHPGAPAPPQQPEESAAGPPAGWGEPPPPAGRAAWPEPEPQPERPAVPEVPRAGDAQPAATVTAAGDTLQGGEAEAPEAAWRRVEGPRETAIGGAGGPAEVSGVFPQGPEDRLSAAPRVDGCRAPRPAAAEPPASPPVCARKRGAAGVGGGPADCPAPGSTPLKKPRRNSEEQPGGAAAAAEEEEEMETGNVANLISIFGSSFSGLLRKSPGGGREEAEGEESGPEAAEPGQICCDKPVLRDINPWSTAIVAF", "length": 311, "header": "tr|A0AAA9S6P1-1|A0AAA9S6P1_BOVIN Isoform 1 of Immediate early response 5 OS=Bos taurus OX=9913 GN=IER5 PE=3 SV=1 CANONICAL=A0AAA9S6P1-1" }, "locus": { "chromosome": "16", "start_pos": 62210314, "end_pos": 62209343, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089473.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089473.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081659.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" }, { "name": "protein phosphatase type 2A complex", "id": "GO:0000159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000159", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" }, { "name": "cellular response to heat", "id": "GO:0034605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" }, { "name": "positive regulation of cellular response to heat", "id": "GO:1900036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6P2-1", "uniprot_ac": "A0AAA9S6P2", "uniprot_id": "A0AAA9S6P2_BOVIN", "mass": { "chemical_mass": 278949.0, "monoisotopic_mass": 278949.0 }, "refseq": { "ac": "XP_024838239", "name": "stabilin-1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838239" }, "gene_names": [ { "name": "STAB1", "type": "recommended", "evidence": [ { "id": "A0AAA9S6P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ] }, { "name": "STAB1", "type": "synonym", "evidence": [ { "id": "XP_024838239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838239" } ] } ], "protein_names": [ { "name": "Stabilin 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S6P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2/entry#names_and_taxonomy" } ] }, { "name": "stabilin-1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024838239", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838239" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2", "locus": { "chromosome": "22", "start_pos": 48343002, "end_pos": 48368609, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014782", "url": "https://www.ensembl.org/id/ENSBTAG00000014782" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014782", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014782", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505543", "url": "https://www.ncbi.nlm.nih.gov/gene/505543", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BNJ1", "url": "https://www.orthodb.org/?gene=E1BNJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24038:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24038:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02469", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02469", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12947", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12947", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24887", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24887", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3000497", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000497", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024838239", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838239", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNJ1", "url": "https://www.uniprot.org/uniprotkb/E1BNJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNJ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BNJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPRGHLLLCFLALCLAGPSFFGEQKAPPSMGFSRQEYWSGLPFPSPGDLPDQGIEPVSLSLLHWQVRSKRCDVKTKFVTHIPCTPCPAIKKRVCPLGWIRAFPEKISQDCRYEVQLGDSLLSMSGCSLECWKDMVQKACCPGYWGSQCYECPGGAETPCSGHGTCLDGLDGNGTCVCQENFSGSACQECRDPNRFGPDCQSVCRCVHGVCRHGPRGDGSCLCFAGYTGARCDQELLACQALNCPRNSQCSEEAPSCSCLPGYTQQGHECRASDPCRPSPCSPLAQCSVGPGGQAQCRCPENYHGDGTVCLPQDPCTTNNGGCPSNSTLCLYRKPGQASCLCKPGLVSIAHDSSAGCFAHCSAFSCDRSATCQVTPDGKTSCVCKEGEVGDGRACYGHLLHEVQKASQTSMLLRLRVTFAMLDQGCREILSTSGPFTVLAPLVSSRTMNASVAQQLCRQHIIAGQHMLEEAGTQAPRRWWTLAGQEITVSFSRFRKYTYKYQDQPQQTFTIHKANYPAANGLFHVVTALRLQPPPELPEDPKRTIGQILASNEVFSRFETILENCGLPSFLDGPGPFTVFAPSNEAVDGLRDGRLVYLFTAGLSKLQELVRYHVYNHGQLTVEKLLSKGRVLTMANQILAVNISEEGRILLGPEGVPLRRVDVLAANGVIHMLEGVLLPPTILPILPKLCNEEQHAVVAGSCVDCQALNTSTCPPNSVKLDISPEECVYIHDPTGLNVLKKGCAYYCNQTIQKPGCCKGFFGPDCLQCPGGFSNPCYGKGNCSDGVQGSGACLCFPDYKGIACHICSNPNKHGDQCQEDCGCVHGLCDNRPGSGGVCQHGTCAPGFSGRFCNESTVSCGSTEQAQQCHPHARCVNQGGVSRCLCLDGFEGDGFSCTPSDPCSRPDRGGCSENAECVPGVRGAHHCMCHKGWSGDGRVCVAVDECELDLRGGCHADALCSYVGPGQSRCTCKLGFAGDGYVCSPIDPCRAGNGGCHDLATCRAVGGGQRVCTCPPDYGGDGFSCYGDILKELEANAHFSVFYQWIKGAGITLPADSQVTALVPSESAIRRLSTEDQAFWLQPRLLPQLVRAHFLQGALSEEELARLHGQNVSTLNPTVRWEIHNVSGRVWVQNASVDVADLLATNGVLHVLSQVLLPPRRDVLGGQGLLQQLDSVPAFHLFRELLQRHRLVPQIEAATAYTIFVPTNHSLEAQANSSSLDSDVVRHHVILGEALSTEALGKGGHRNSLLGPAHWLVFYNHSGQPEVNHVPLEGPVLQAPGRSLFGLSGVLTVGSSRCLHSHAEALREKCVNCSRKFRCTQGYQLEDTPRKSCVYRSGYSFSRGCSYTCAKKIQVPDCCPGFFGTLCEPCPGGLGGVCSGHGQCQDRLLGSGECRCHEGFHGTACEMCELGRYGPNCTGVCDCAHGLCQEGLRGDGSCVCNVGWQGLRCDQKISGPQCLQKCDPNANCVQDSAAAPVCVCAAGYSGDGVSCSAVDPCARDHGGCSPHANCTTVAPGQRTCTCLDGYTGDGELCREANSCLIRHGGCHMHAECIPTGPQQVSCSCREGYSGDGIRACVLLDPCSQNNGGCSPYAVCKSTGDGQRTCACDAVRTVGDGFTCRARISLELLRDKHASFFSLHLLEYKDLKGDGPFTVFVPHADLLTNMSQDELARIRANRQLVFRYHVVGCRQLRSQELLEEGYATALSGHPLRFSEREGNIYINDFARVVSSDQEAVNGVLHFIDRVLLPPEVLHWEADAAPAPRRNFTAAAETFGYKIFSGLVTMAGLLPLLQDSSHRPLTMLWPTDSALQALPPDRQVWLYHKDHRDKLAAILRGHVIRNVEALASDLPNLGPLRTMHGTPISFSCSHARPGALTVGEDAARIVQRHLPFEGGLAYGIDQLLEPPGLGARCDRFETRPLWLKVCSICGLEPPCPPGSQEQGSPEACWRYFSKFWTSPPLHSLALRSVWTRPSHWGHPQGLGRGCYRNCVTTTWKPSCCPGHYGSECRACPGGASSPCNQRGSCMDGMSGSGECRCHTRFAGTACELCAPGAFGPLCQACNCTSHGRCDEGLGGSGSCFCDEGWTGPRCEVQLELQPVCAPPCAPQAVCRAGNSCECSLGYEGDGRTCTVVNLCQDGRGGCSEHANCSQAGTAVTCICWPDYEGDGWSCRARNPCEDGLRGGCSEHADCLNTGPNTRRCVCHAGYVGDGLQCLLEPEPPVDRCLDRPPPCHADAVCTDLHFQEKRAGVFHLQAPSGPYGLNFSEAEAACGAQGAVLASLLQLSAAQQLGLHLCLVGWLANGSAAHPVVFPAADCGDGQVGVVSLGARENLSERWDAYCFRMRDVACRCRDGFVGDGTSVCNGKLLDVLATTANFSIFYGMLLGYANATPRGLEFLDFLDDERTYKTLFVPVDEAFTDNTTLSGPDLELHASNTTFLSANASQGALLPAHSGLSLVIGNLGPGNSSRAPEVPGAVVVSRVIVWDILAFNGIIHTLASPLLAPPQAWAVVAPEAPPVAAGVGAVVAAGAVLGLVAGALYFRGRSRSAGFGFSAFQAEDAAADDFSPWQEGTSPPLVSVPNPVFGSHEAFCEPFDDSVLEEDFPDTQRILEVK", "length": 2608, "header": "tr|A0AAA9S6P2-1|A0AAA9S6P2_BOVIN Isoform 1 of Stabilin 1 OS=Bos taurus OX=9913 GN=STAB1 PE=4 SV=1 CANONICAL=A0AAA9S6P2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2/entry#A0AAA9S6P2-1", "sequence": { "sequence": "MAGPRGHLLLCFLALCLAGPSFFGEQKAPPSMGFSRQEYWSGLPFPSPGDLPDQGIEPVSLSLLHWQVRSKRCDVKTKFVTHIPCTPCPAIKKRVCPLGWIRAFPEKISQDCRYEVQLGDSLLSMSGCSLECWKDMVQKACCPGYWGSQCYECPGGAETPCSGHGTCLDGLDGNGTCVCQENFSGSACQECRDPNRFGPDCQSVCRCVHGVCRHGPRGDGSCLCFAGYTGARCDQELLACQALNCPRNSQCSEEAPSCSCLPGYTQQGHECRASDPCRPSPCSPLAQCSVGPGGQAQCRCPENYHGDGTVCLPQDPCTTNNGGCPSNSTLCLYRKPGQASCLCKPGLVSIAHDSSAGCFAHCSAFSCDRSATCQVTPDGKTSCVCKEGEVGDGRACYGHLLHEVQKASQTSMLLRLRVTFAMLDQGCREILSTSGPFTVLAPLVSSRTMNASVAQQLCRQHIIAGQHMLEEAGTQAPRRWWTLAGQEITVSFSRFRKYTYKYQDQPQQTFTIHKANYPAANGLFHVVTALRLQPPPELPEDPKRTIGQILASNEVFSRFETILENCGLPSFLDGPGPFTVFAPSNEAVDGLRDGRLVYLFTAGLSKLQELVRYHVYNHGQLTVEKLLSKGRVLTMANQILAVNISEEGRILLGPEGVPLRRVDVLAANGVIHMLEGVLLPPTILPILPKLCNEEQHAVVAGSCVDCQALNTSTCPPNSVKLDISPEECVYIHDPTGLNVLKKGCAYYCNQTIQKPGCCKGFFGPDCLQCPGGFSNPCYGKGNCSDGVQGSGACLCFPDYKGIACHICSNPNKHGDQCQEDCGCVHGLCDNRPGSGGVCQHGTCAPGFSGRFCNESTVSCGSTEQAQQCHPHARCVNQGGVSRCLCLDGFEGDGFSCTPSDPCSRPDRGGCSENAECVPGVRGAHHCMCHKGWSGDGRVCVAVDECELDLRGGCHADALCSYVGPGQSRCTCKLGFAGDGYVCSPIDPCRAGNGGCHDLATCRAVGGGQRVCTCPPDYGGDGFSCYGDILKELEANAHFSVFYQWIKGAGITLPADSQVTALVPSESAIRRLSTEDQAFWLQPRLLPQLVRAHFLQGALSEEELARLHGQNVSTLNPTVRWEIHNVSGRVWVQNASVDVADLLATNGVLHVLSQVLLPPRRDVLGGQGLLQQLDSVPAFHLFRELLQRHRLVPQIEAATAYTIFVPTNHSLEAQANSSSLDSDVVRHHVILGEALSTEALGKGGHRNSLLGPAHWLVFYNHSGQPEVNHVPLEGPVLQAPGRSLFGLSGVLTVGSSRCLHSHAEALREKCVNCSRKFRCTQGYQLEDTPRKSCVYRSGYSFSRGCSYTCAKKIQVPDCCPGFFGTLCEPCPGGLGGVCSGHGQCQDRLLGSGECRCHEGFHGTACEMCELGRYGPNCTGVCDCAHGLCQEGLRGDGSCVCNVGWQGLRCDQKISGPQCLQKCDPNANCVQDSAAAPVCVCAAGYSGDGVSCSAVDPCARDHGGCSPHANCTTVAPGQRTCTCLDGYTGDGELCREANSCLIRHGGCHMHAECIPTGPQQVSCSCREGYSGDGIRACVLLDPCSQNNGGCSPYAVCKSTGDGQRTCACDAVRTVGDGFTCRARISLELLRDKHASFFSLHLLEYKDLKGDGPFTVFVPHADLLTNMSQDELARIRANRQLVFRYHVVGCRQLRSQELLEEGYATALSGHPLRFSEREGNIYINDFARVVSSDQEAVNGVLHFIDRVLLPPEVLHWEADAAPAPRRNFTAAAETFGYKIFSGLVTMAGLLPLLQDSSHRPLTMLWPTDSALQALPPDRQVWLYHKDHRDKLAAILRGHVIRNVEALASDLPNLGPLRTMHGTPISFSCSHARPGALTVGEDAARIVQRHLPFEGGLAYGIDQLLEPPGLGARCDRFETRPLWLKVCSICGLEPPCPPGSQEQGSPEACWRYFSKFWTSPPLHSLALRSVWTRPSHWGHPQGLGRGCYRNCVTTTWKPSCCPGHYGSECRACPGGASSPCNQRGSCMDGMSGSGECRCHTRFAGTACELCAPGAFGPLCQACNCTSHGRCDEGLGGSGSCFCDEGWTGPRCEVQLELQPVCAPPCAPQAVCRAGNSCECSLGYEGDGRTCTVVNLCQDGRGGCSEHANCSQAGTAVTCICWPDYEGDGWSCRARNPCEDGLRGGCSEHADCLNTGPNTRRCVCHAGYVGDGLQCLLEPEPPVDRCLDRPPPCHADAVCTDLHFQEKRAGVFHLQAPSGPYGLNFSEAEAACGAQGAVLASLLQLSAAQQLGLHLCLVGWLANGSAAHPVVFPAADCGDGQVGVVSLGARENLSERWDAYCFRMRDVACRCRDGFVGDGTSVCNGKLLDVLATTANFSIFYGMLLGYANATPRGLEFLDFLDDERTYKTLFVPVDEAFTDNTTLSGPDLELHASNTTFLSANASQGALLPAHSGLSLVIGNLGPGNSSRAPEVPGAVVVSRVIVWDILAFNGIIHTLASPLLAPPQAWAVVAPEAPPVAAGVGAVVAAGAVLGLVAGALYFRGRSRSAGFGFSAFQAEDAAADDFSPWQEGTSPPLVSVPNPVFGSHEAFCEPFDDSVLEEDFPDTQRILEVK", "length": 2608, "header": "tr|A0AAA9S6P2-1|A0AAA9S6P2_BOVIN Isoform 1 of Stabilin 1 OS=Bos taurus OX=9913 GN=STAB1 PE=4 SV=1 CANONICAL=A0AAA9S6P2-1" }, "locus": { "chromosome": "22", "start_pos": 48368328, "end_pos": 48343097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118361.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118361.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079578.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079578.1" } ] } }, { "isoform_ac": "E1BNJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2/entry#E1BNJ1-1", "sequence": { "sequence": "MAGPRGHLLLCFLALCLAGPSFFGEQKGPGPSLQTLPLGQVRSKRCDVKTKFVTHIPCTPCPAIKKRVCPLGWIRAFPEKISQDCRYEVQLGDSLLSMSGCSLECWKDMVQKACCPGYWGSQCYECPGGAETPCSGHGTCLDGLDGNGTCVCQENFSGSACQECRDPNRFGPDCQSVCRCVHGVCRHGPRGDGSCLCFAGYTGARCDQELLACQALNCPRNSQCSEEAPSCSCLPGYTQQGHECRASDPCRPSPCSPLAQCSVGPGGQAQCRCPENYHGDGTVCLPQDPCTTNNGGCPSNSTLCLYRKPGQASCLCKPGLVSIAHDSSAGCFAHCSAFSCDRSATCQVTPDGKTSCVCKEGEVGDGRACYGHLLHEVQKASQTSMLLRLRVTFAMLDQGCREILSTSGPFTVLAPLVSSRTMNASVAQQLCRQHIIAGQHMLEEAGTQAPRRWWTLAGQEITVSFSRFRKYTYKYQDQPQQTFTIHKANYPAANGLFHVVTALRLQPPPELPEDPKRTIGQILASNEVFSRFETILENCGLPSFLDGPGPFTVFAPSNEAVDGLRDGRLVYLFTAGLSKLQELVRYHVYNHGQLTVEKLLSKGRVLTMANQILAVNISEEGRILLGPEGVPLRRVDVLAANGVIHMLEGVLLPPTILPILPKLCNEEQHAVVAGSCVDCQALNTSTCPPNSVKLDISPEECVYIHDPTGLNVLKKGCAYYCNQTIQKPGCCKGFFGPDCLQCPGGFSNPCYGKGNCSDGVQGSGACLCFPDYKGIACHICSNPNKHGDQCQEDCGCVHGLCDNRPGSGGVCQHGTCAPGFSGRFCNESTVSCGSTEQAQQCHPHARCVNQGGVSRCLCLDGFEGDGFSCTPSDPCSRPDRGGCSENAECVPGVRGAHHCMCHKGWSGDGRVCVAVDECELDLRGGCHADALCSYVGPGQSRCTCKLGFAGDGYVCSPIDPCRAGNGGCHDLATCRAVGGGQRVCTCPPDYGGDGFSCYGDILKELEANAHFSVFYQWIKGAGITLPADSQVTALVPSESAIRRLSTEDQAFWLQPRLLPQLVRAHFLQGALSEEELARLHGQNVSTLNPTVRWEIHNVSGRVWVQNASVDVADLLATNGVLHVLSQVLLPPRRDVLGGQGLLQQLDSVPAFHLFRELLQRHRLVPQIEAATAYTIFVPTNHSLEAQANSSSLDSDVVRHHVILGEALSTEALGKGGHRNSLLGPAHWLVFYNHSGQPEVNHVPLEGPVLQAPGRSLFGLSGVLTVGSSRCLHSHAEALREKCVNCSRKFRCTQGYQLEDTPRKSCVYRSGYSFSRGCSYTCAKKIQVPDCCPGFFGTLCEPCPGGLGGVCSGHGQCQDRLLGSGECRCHEGFHGTACEMCELGRYGPNCTGVCDCAHGLCQEGLRGDGSCVCNVGWQGLRCDQKISGPQCLQKCDPNANCVQDSAAAPVCVCAAGYSGDGVSCSAVDPCARDHGGCSPHANCTTVAPGQRTCTCLDGYTGDGELCREANSCLIRHGGCHMHAECIPTGPQQVSCSCREGYSGDGIRACVLLDPCSQNNGGCSPYAVCKSTGDGQRTCACDAVRTVGDGFTCRARISLELLRDKHASFFSLHLLEYKDLKGDGPFTVFVPHADLLTNMSQDELARIRANRQLVFRYHVVGCRQLRSQELLEEGYATALSGHPLRFSEREGNIYINDFARVVSSDQEAVNGVLHFIDRVLLPPEVLHWEADAAPAPRRNFTAAAETFGYKIFSGLVTMAGLLPLLQDSSHRPLTMLWPTDSALQALPPDRQVWLYHKDHRDKLAAILRGHVIRNVEALASDLPNLGPLRTMHGTPISFSCSHARPGALTVGEDAARIVQRHLPFEGGLAYGIDQLLEPPGLGARCDRFETRPLWLKVCSICGLEPPCPPGSQEQGSPEACWRYFSKFWTSPPLHSLALRSVWTRPSHWGHPQGLGRGCYRNCVTTTWKPSCCPGHYGSECRACPGGASSPCNQRGSCMDGMSGSGECRCHTRFAGTACELCAPGAFGPLCQACNCTSHGRCDEGLGGSGSCFCDEGWTGPRCEVQLELQPVCAPPCAPQAVCRAGNSCECSLGYEGDGRTCTVVNLCQDGRGGCSEHANCSQAGTAVTCICWPDYEGDGWSCRARNPCEDGLRGGCSEHADCLNTGPNTRRCVCHAGYVGDGLQCLLEPEPPVDRCLDRPPPCHADAVCTDLHFQEKRAGVFHLQAPSGPYGLNFSEAEAACGAQGAVLASLLQLSAAQQLGLHLCLVGWLANGSAAHPVVFPAADCGDGQVGVVSLGARENLSERWDAYCFRMRDVACRCRDGFVGDGTSVCNGKLLDVLATTANFSIFYGMLLGYANATPRGLEFLDFLDDERTYKTLFVPVDEAFTDNTTLSGPDLELHASNTTFLSANASQGALLPAHSGLSLVIGNLGPGNSSRAPEVPGAVVVSRVIVWDILAFNGIIHTLASPLLAPPQAWAVVAPEAPPVAAGVGAVVAAGAVLGLVAGALYFRGRSRSAGFGFSAFQAEDAAADDFSPWQEGTSPPLVSVPNPVFGSHEAFCEPFDDSVLEEDFPDTQRILEVK", "length": 2581, "header": "tr|E1BNJ1-1|E1BNJ1_BOVIN Computationally mapped isoform of Stabilin 1 OS=Bos taurus OX=9913 GN=STAB1 PE=4 SV=3 CANONICAL=A0AAA9S6P2-1" }, "locus": { "chromosome": "22", "start_pos": 48368328, "end_pos": 48343097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019663.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019663.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019663.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019663.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3000497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000497", "resource": "Reactome", "description": "Scavenging by Class H Receptors" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "scavenger receptor activity", "id": "GO:0005044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005044", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor activity", "id": "GO:0005041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "low-density lipoprotein particle binding", "id": "GO:0030169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030169", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1110, "end_pos": 1112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1124, "end_pos": 1126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1133, "end_pos": 1135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1207, "end_pos": 1209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1215, "end_pos": 1217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1259, "end_pos": 1261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1311, "end_pos": 1313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1415, "end_pos": 1417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1508, "end_pos": 1510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1663, "end_pos": 1665, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1764, "end_pos": 1766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2059, "end_pos": 2061, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2144, "end_pos": 2146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2259, "end_pos": 2261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2298, "end_pos": 2300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2327, "end_pos": 2329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2371, "end_pos": 2373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2384, "end_pos": 2386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2416, "end_pos": 2418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2430, "end_pos": 2432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2437, "end_pos": 2439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2461, "end_pos": 2463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 782, "end_pos": 784, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 151, "end_pos": 189, "start_aa": "Tyr", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" }, { "id": "PS50213", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50213" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAS1", "eco_id": "ECO_0000259", "start_pos": 397, "end_pos": 531, "start_aa": "Tyr", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P2" }, { "id": "PS50963", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50963" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link", "eco_id": "ECO_0000259", "start_pos": 2245, "end_pos": 2338, "start_aa": "Gly", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1110, "end_pos": 1112 }, { "start_pos": 1124, "end_pos": 1126 }, { "start_pos": 1133, "end_pos": 1135 }, { "start_pos": 1207, "end_pos": 1209 }, { "start_pos": 1215, "end_pos": 1217 }, { "start_pos": 1259, "end_pos": 1261 }, { "start_pos": 1311, "end_pos": 1313 }, { "start_pos": 1415, "end_pos": 1417 }, { "start_pos": 1508, "end_pos": 1510 }, { "start_pos": 1663, "end_pos": 1665 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 1764, "end_pos": 1766 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 2059, "end_pos": 2061 }, { "start_pos": 2144, "end_pos": 2146 }, { "start_pos": 2259, "end_pos": 2261 }, { "start_pos": 2298, "end_pos": 2300 }, { "start_pos": 2327, "end_pos": 2329 }, { "start_pos": 2371, "end_pos": 2373 }, { "start_pos": 2384, "end_pos": 2386 }, { "start_pos": 2416, "end_pos": 2418 }, { "start_pos": 2430, "end_pos": 2432 }, { "start_pos": 2437, "end_pos": 2439 }, { "start_pos": 2461, "end_pos": 2463 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 450, "end_pos": 452 }, { "start_pos": 643, "end_pos": 645 }, { "start_pos": 710, "end_pos": 712 }, { "start_pos": 749, "end_pos": 751 }, { "start_pos": 782, "end_pos": 784 }, { "start_pos": 853, "end_pos": 855 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6Q8-1", "uniprot_ac": "A0AAA9S6Q8", "uniprot_id": "A0AAA9S6Q8_BOVIN", "mass": { "chemical_mass": 25042.0, "monoisotopic_mass": 25042.0 }, "refseq": { "ac": "XP_059740753", "name": "leucine-rich repeat-containing protein 7 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740753" }, "gene_names": [ { "name": "LRRC7", "type": "recommended", "evidence": [ { "id": "A0AAA9S6Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8" } ] }, { "name": "LRRC7", "type": "synonym", "evidence": [ { "id": "XP_059740753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740753" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 7", "type": "synonym", "evidence": [ { "id": "A0AAA9S6Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 7 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059740753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740753" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8", "locus": { "chromosome": "3", "start_pos": 75039363, "end_pos": 75151942, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009338", "url": "https://www.ensembl.org/id/ENSBTAG00000009338" } ] } } ], "crossref": [ { "id": "A0AAA9S6Q8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6Q8", "database": "AlphaFoldDB", "categories": [] }, { "id": "538844", "url": "https://www.ncbi.nlm.nih.gov/gene/538844", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059740753", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740753", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMENLIRGRNPPQYQRSPCKEVRAALRKRPEEELQCLEMTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALKKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLAKLRILELRENHLKTLPNI", "length": 217, "header": "tr|A0AAA9S6Q8-1|A0AAA9S6Q8_BOVIN Isoform 1 of Leucine rich repeat containing 7 OS=Bos taurus OX=9913 GN=LRRC7 PE=4 SV=1 CANONICAL=A0AAA9S6Q8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Q8/entry#A0AAA9S6Q8-1", "sequence": { "sequence": "MMENLIRGRNPPQYQRSPCKEVRAALRKRPEEELQCLEMTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALKKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLAKLRILELRENHLKTLPNI", "length": 217, "header": "tr|A0AAA9S6Q8-1|A0AAA9S6Q8_BOVIN Isoform 1 of Leucine rich repeat containing 7 OS=Bos taurus OX=9913 GN=LRRC7 PE=4 SV=1 CANONICAL=A0AAA9S6Q8-1" }, "locus": { "chromosome": "3", "start_pos": 75644478, "end_pos": 75281790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127575.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127575.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079594.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079594.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6R1-1", "uniprot_ac": "A0AAA9S6R1", "uniprot_id": "A0AAA9S6R1_BOVIN", "mass": { "chemical_mass": 31400.0, "monoisotopic_mass": 31400.0 }, "refseq": { "ac": "XP_005219683", "name": "protein FRG2-like-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219683" }, "gene_names": [ { "name": "LOC101904879", "type": "recommended", "evidence": [ { "id": "A0AAA9S6R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1" } ] }, { "name": "LOC101904879", "type": "synonym", "evidence": [ { "id": "XP_005219683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219683" } ] } ], "protein_names": [ { "name": "Protein FRG2-like-1", "type": "recommended", "evidence": [ { "id": "A0AAA9S6R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1/entry#names_and_taxonomy" } ] }, { "name": "protein FRG2-like-2", "type": "synonym", "evidence": [ { "id": "XP_005219683", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219683" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101904879", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6R1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6R1", "database": "AlphaFoldDB", "categories": [] }, { "id": "101904879", "url": "https://www.ncbi.nlm.nih.gov/gene/101904879", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101904879", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904879", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31883", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31883", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31883:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31883:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15315", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15315", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005219683", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219683", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESGTEDRHPNSPSMEQPTDQTPSQQDSFEEKSSDVEEKLSEGKGEIVSSQLQQNSMEERGSDGEEKRSEEKGSEPEMDEKDNSKENETQDRNRHTAPSDSERGSSSESSRKRKVDSRNRTCDGTGASPHEPSVTLENKKRKVLESGRSSSSEKTRAPRSRRPHPRRPGRSQRPRSRSPEDQLPPLRKSLVTSLRYMSEAIYQSIVHMHKQPGYSPQCWQQLAQLREPLWAAAQTIYTMANEAAYAFPAEGWLSPAPAQGTLRPTKDGVEGPSSEASPPLL", "length": 281, "header": "tr|A0AAA9S6R1-1|A0AAA9S6R1_BOVIN Isoform 1 of Protein FRG2-like-1 OS=Bos taurus OX=9913 GN=LOC101904879 PE=4 SV=1 CANONICAL=A0AAA9S6R1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R1/entry#A0AAA9S6R1-1", "sequence": { "sequence": "MESGTEDRHPNSPSMEQPTDQTPSQQDSFEEKSSDVEEKLSEGKGEIVSSQLQQNSMEERGSDGEEKRSEEKGSEPEMDEKDNSKENETQDRNRHTAPSDSERGSSSESSRKRKVDSRNRTCDGTGASPHEPSVTLENKKRKVLESGRSSSSEKTRAPRSRRPHPRRPGRSQRPRSRSPEDQLPPLRKSLVTSLRYMSEAIYQSIVHMHKQPGYSPQCWQQLAQLREPLWAAAQTIYTMANEAAYAFPAEGWLSPAPAQGTLRPTKDGVEGPSSEASPPLL", "length": 281, "header": "tr|A0AAA9S6R1-1|A0AAA9S6R1_BOVIN Isoform 1 of Protein FRG2-like-1 OS=Bos taurus OX=9913 GN=LOC101904879 PE=4 SV=1 CANONICAL=A0AAA9S6R1-1" }, "locus": { "chromosome": "18", "start_pos": 60124229, "end_pos": 60122543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131567.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131567.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079599.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079599.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101904879", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904879", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6R2-1", "uniprot_ac": "A0AAA9S6R2", "uniprot_id": "A0AAA9S6R2_BOVIN", "mass": { "chemical_mass": 12898.0, "monoisotopic_mass": 12898.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "T cell receptor delta variable 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S6R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6R2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6R2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6R2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6R2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAVVLVPQDQEKTVVVGKSATLSCSMKGATFISKYYIFWYRKTPGNTMTFIYQEWGLYGPGFKDNFRGKIVNLTNQAVLEVLKASERDEGFYYCATDYHPAAGSLLSNSKNTEI", "length": 115, "header": "tr|A0AAA9S6R2-1|A0AAA9S6R2_BOVIN Isoform 1 of T cell receptor delta variable 2 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6R2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6R2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2/entry#A0AAA9S6R2-1", "sequence": { "sequence": "MSAVVLVPQDQEKTVVVGKSATLSCSMKGATFISKYYIFWYRKTPGNTMTFIYQEWGLYGPGFKDNFRGKIVNLTNQAVLEVLKASERDEGFYYCATDYHPAAGSLLSNSKNTEI", "length": 115, "header": "tr|A0AAA9S6R2-1|A0AAA9S6R2_BOVIN Isoform 1 of T cell receptor delta variable 2 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6R2-1" }, "locus": { "chromosome": "10", "start_pos": 22478473, "end_pos": 22478129, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131103.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131103.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081681.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 114, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6T3-1", "uniprot_ac": "A0AAA9S6T3", "uniprot_id": "A0AAA9S6T3_BOVIN", "mass": { "chemical_mass": 13907.0, "monoisotopic_mass": 13907.0 }, "refseq": { "ac": "XP_059744611", "name": "histone H2B type 1-C/E/F/G/I-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744611" }, "gene_names": [ { "name": "LOC132345710", "type": "recommended", "evidence": [ { "id": "A0AAA9S6T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ] }, { "name": "LOC132345710", "type": "synonym", "evidence": [ { "id": "XP_059744611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744611" } ] } ], "protein_names": [ { "name": "Core Histone H2A/H2B/H3 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S6T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3/entry#names_and_taxonomy" } ] }, { "name": "histone H2B type 1-C/E/F/G/I-like", "type": "synonym", "evidence": [ { "id": "XP_059744611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744611" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132345710", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6T3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6T3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22910", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22910", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "132345710", "url": "https://www.ncbi.nlm.nih.gov/gene/132345710", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:132345710", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132345710", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CNINSRA", "url": "https://omabrowser.org/oma/group/CNINSRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059744611", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744611", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPERAKSAPAPKKGSKKAVTKAQKKDGKKLKHSRKESYSVYMYKVLKQVHPDTGISSKAMGIMNSFVNDIFECTAGEASRLAHYNKRLTITSREIQTAVHLLLPGELAKHAVSESTKAVTKYTSSK", "length": 126, "header": "tr|A0AAA9S6T3-1|A0AAA9S6T3_BOVIN Isoform 1 of Core Histone H2A/H2B/H3 domain-containing protein OS=Bos taurus OX=9913 GN=LOC132345710 PE=3 SV=1 CANONICAL=A0AAA9S6T3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3/entry#A0AAA9S6T3-1", "sequence": { "sequence": "MPERAKSAPAPKKGSKKAVTKAQKKDGKKLKHSRKESYSVYMYKVLKQVHPDTGISSKAMGIMNSFVNDIFECTAGEASRLAHYNKRLTITSREIQTAVHLLLPGELAKHAVSESTKAVTKYTSSK", "length": 126, "header": "tr|A0AAA9S6T3-1|A0AAA9S6T3_BOVIN Isoform 1 of Core Histone H2A/H2B/H3 domain-containing protein OS=Bos taurus OX=9913 GN=LOC132345710 PE=3 SV=1 CANONICAL=A0AAA9S6T3-1" }, "locus": { "chromosome": "7", "start_pos": 17985379, "end_pos": 17985002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090787.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090787.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077872.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077872.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132345710", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132345710", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PY49-1", "protein_name": "Histone H2B", "gene_name": "H2BK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAESGRMRGHPSSSGDKKSKRKPKRKETYSVYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERLAVEASRLAQYNHRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK", "length": 118 }, "evidence": [ { "id": "A0AAA9S6T3", "url": "https://omabrowser.org/oma/group/A0AAA9S6T3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P02283-1", "protein_name": "Histone H2B", "gene_name": "His2B:CG33876", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPPKTSGKAAKKAGKAQKNITKTDKKKKRKRKESYAIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK", "length": 123 }, "evidence": [ { "id": "A0AAA9S6T3", "url": "https://omabrowser.org/oma/group/A0AAA9S6T3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P10853-1", "protein_name": "Histone H2B type 1-F/J/L", "gene_name": "H2bc15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK", "length": 126 }, "evidence": [ { "id": "A0AAA9S6T3", "url": "https://omabrowser.org/oma/group/A0AAA9S6T3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPDPSKSAPAPKKGSKKAVTKAQKKDGKKRKRGRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIASEASRLAHYNKRSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK", "length": 126 }, "evidence": [ { "id": "A0AAA9S6T3", "url": "https://omabrowser.org/oma/group/A0AAA9S6T3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6T3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6T3" }, { "id": "PF00125", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Core Histone H2A/H2B/H3", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 101, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6W6-1", "uniprot_ac": "A0AAA9S6W6", "uniprot_id": "A0AAA9S6W6_BOVIN", "mass": { "chemical_mass": 62877.0, "monoisotopic_mass": 62877.0 }, "refseq": {}, "gene_names": [ { "name": "LOC784148", "type": "recommended", "evidence": [ { "id": "A0AAA9S6W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" } ] } ], "protein_names": [ { "name": "Zinc finger protein 709", "type": "recommended", "evidence": [ { "id": "A0AAA9S6W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC784148", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6W6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6W6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784148", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784148", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6W6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DSVTFEDVAVNFTLEEWAFLDPSQKKLYRDVMRETLRNLVSIGEKWEDHDIEDQYKNQGRKLRSHVVERLCENKEGSQCGENFSIIPNLNMNKKTNRMKRRECSVCGKVFTRHSSLKRHMSYHTERKPPEYQKYGEKPYRCKECGKAFAYLQFLETHEKNHNREKKYKCEECGKAFHSRASFQAHERIHTGEKPYECKECGEAFMWSTGFRRHMVTHTGNASYTCKKCGKAFNCSSSLRTHETTHSDKKPYQCKQCGKFLRYYHTFRTHQRTHTGEKPYECKQCGKAFSCPSSFRKHERIHTGEKPYECKECGRTFRGLSSLRAHMITHTGDGPYKCQECERAFISPSSFRIHQRIHTGEKPYKCEQCGKAFNYYNSLQSHRRTHTGEKPYECKECGKTLSHQQTLKIHMRLHTGEKPYECKQCGKAFRYYPSFHKHKRSHTGGKPFECKQCGKAFSHYNSLQSHGRTHTGEKPYKCKECGKALSHHQTLRVHMRLHTGEKPYECSQCSRAFRYYTSFQKHKRIHTEKKFYE", "length": 532, "header": "tr|A0AAA9S6W6-1|A0AAA9S6W6_BOVIN Isoform 1 of Zinc finger protein 709 OS=Bos taurus OX=9913 GN=LOC784148 PE=3 SV=2 CANONICAL=A0AAA9S6W6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6W6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6/entry#A0AAA9S6W6-1", "sequence": { "sequence": "DSVTFEDVAVNFTLEEWAFLDPSQKKLYRDVMRETLRNLVSIGEKWEDHDIEDQYKNQGRKLRSHVVERLCENKEGSQCGENFSIIPNLNMNKKTNRMKRRECSVCGKVFTRHSSLKRHMSYHTERKPPEYQKYGEKPYRCKECGKAFAYLQFLETHEKNHNREKKYKCEECGKAFHSRASFQAHERIHTGEKPYECKECGEAFMWSTGFRRHMVTHTGNASYTCKKCGKAFNCSSSLRTHETTHSDKKPYQCKQCGKFLRYYHTFRTHQRTHTGEKPYECKQCGKAFSCPSSFRKHERIHTGEKPYECKECGRTFRGLSSLRAHMITHTGDGPYKCQECERAFISPSSFRIHQRIHTGEKPYKCEQCGKAFNYYNSLQSHRRTHTGEKPYECKECGKTLSHQQTLKIHMRLHTGEKPYECKQCGKAFRYYPSFHKHKRSHTGGKPFECKQCGKAFSHYNSLQSHGRTHTGEKPYKCKECGKALSHHQTLRVHMRLHTGEKPYECSQCSRAFRYYTSFQKHKRIHTEKKFYE", "length": 532, "header": "tr|A0AAA9S6W6-1|A0AAA9S6W6_BOVIN Isoform 1 of Zinc finger protein 709 OS=Bos taurus OX=9913 GN=LOC784148 PE=3 SV=2 CANONICAL=A0AAA9S6W6-1" }, "locus": { "chromosome": "7", "start_pos": 12945877, "end_pos": 12943703, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098984.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098984.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077913.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077913.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784148", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784148", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 128, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W6" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 89, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 220, "end_pos": 222 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6X0-1", "uniprot_ac": "A0AAA9S6X0", "uniprot_id": "A0AAA9S6X0_BOVIN", "mass": { "chemical_mass": 33755.0, "monoisotopic_mass": 33755.0 }, "refseq": {}, "gene_names": [ { "name": "PNPLA4", "type": "recommended", "evidence": [ { "id": "A0AAA9S6X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ] } ], "protein_names": [ { "name": "Patatin like phospholipase domain containing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9S6X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PNPLA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0", "locus": { "chromosome": "X", "start_pos": 134951233, "end_pos": 134903796, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015849", "url": "https://www.ensembl.org/id/ENSBTAG00000015849" } ] } } ], "crossref": [ { "id": "A0AAA9S6X0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6X0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785567", "url": "https://www.ncbi.nlm.nih.gov/gene/785567", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3X777", "url": "https://www.orthodb.org/?gene=G3X777", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12406:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12406:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01734", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01734", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163560", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163560", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X777", "url": "https://www.uniprot.org/uniprotkb/G3X777", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X777-1", "url": "https://www.uniprot.org/uniprotkb/G3X777-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLCAEVSQTCTDSLPTEPQGKPKNTGVSSLSLLQGIFPTQESNRGLAHIEARMKHINLSFAACGFLGIYHLGAASALYNHGRKLLKDVKACAGASAGSLVASVLLTAPQKIEECNKFTYDFAEEIRRQSFGALTPGYDFMARLRSGVESILPANAHELAHGRLHVSITNTRTRRNCLVSSFPSREDLVKVLLASSFLPIYAGLKPVEYKGQRWVDGGFTNSLPVLPVGRTVTISPFSGRLDVCPQDKGRLHFYVSITNQEVLLSVANLVRLNRALSPPSRRTMELLYRRGFDDASRFLLKENWFE", "length": 306, "header": "tr|A0AAA9S6X0-1|A0AAA9S6X0_BOVIN Isoform 1 of Patatin like phospholipase domain containing 4 OS=Bos taurus OX=9913 GN=PNPLA4 PE=4 SV=1 CANONICAL=A0AAA9S6X0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0/entry#A0AAA9S6X0-1", "sequence": { "sequence": "MLLCAEVSQTCTDSLPTEPQGKPKNTGVSSLSLLQGIFPTQESNRGLAHIEARMKHINLSFAACGFLGIYHLGAASALYNHGRKLLKDVKACAGASAGSLVASVLLTAPQKIEECNKFTYDFAEEIRRQSFGALTPGYDFMARLRSGVESILPANAHELAHGRLHVSITNTRTRRNCLVSSFPSREDLVKVLLASSFLPIYAGLKPVEYKGQRWVDGGFTNSLPVLPVGRTVTISPFSGRLDVCPQDKGRLHFYVSITNQEVLLSVANLVRLNRALSPPSRRTMELLYRRGFDDASRFLLKENWFE", "length": 306, "header": "tr|A0AAA9S6X0-1|A0AAA9S6X0_BOVIN Isoform 1 of Patatin like phospholipase domain containing 4 OS=Bos taurus OX=9913 GN=PNPLA4 PE=4 SV=1 CANONICAL=A0AAA9S6X0-1" }, "locus": { "chromosome": "X", "start_pos": 134949070, "end_pos": 134903995, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127533.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127533.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079039.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079039.1" } ] } }, { "isoform_ac": "A0AAA9SLV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0/entry#A0AAA9SLV2-1", "sequence": { "sequence": "MKHINLSFAACGFLGIYHLGAASALYNHGRKLLKDVKACAGASAGSLVASVLLTAPQKIEECNKFTYDFAEEIRRQSFGALTPGYDFMARLRSGVESILPANAHELAHGRLHVSITNTRTRRNCLVSSFPSREDLVKVLLASSFLPIYAGLKPVEYKGQRWVDGGFTNSLPVLPVGRTVTISPFSGRLDVCPQDKGRLHFYVSITNQEVLPCRILWCVFLSQLSVANLVRLNRALSPPSRRTMELLYRRGFDDASRFLLKENWFE", "length": 265, "header": "tr|A0AAA9SLV2-1|A0AAA9SLV2_BOVIN Computationally mapped isoform of Patatin like phospholipase domain containing 4 OS=Bos taurus OX=9913 GN=PNPLA4 PE=4 SV=2 CANONICAL=A0AAA9S6X0-1" }, "locus": { "chromosome": "X", "start_pos": 134949070, "end_pos": 134906293, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124436.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124436.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086248.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086248.2" } ] } }, { "isoform_ac": "A0AAA9SV90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0/entry#A0AAA9SV90-1", "sequence": { "sequence": "MLLCAEVSQTCVARMKHINLSFAACGFLGIYHLGAASALYNHGRKLLKDVKACAGASAGSLVASVLLTAPQKIEECNKFTYDFAEEIRRQSFGALTPGYDFMARLRSGVESILPANAHELAHGRLHVSITNTRTRRNCLVSSFPSREDLVKVLLASSFLPIYAGLKPVEYKGQRWVDGGFTNSLPVLPVGRTVTISPFSGRLDVCPQDKGRLHFYVSITNQEVLLSVANLVRLNRALSPPSRRTMELLYRRGFDDASRFLLKENWFE", "length": 267, "header": "tr|A0AAA9SV90-1|A0AAA9SV90_BOVIN Computationally mapped isoform of Patatin like phospholipase domain containing 4 OS=Bos taurus OX=9913 GN=PNPLA4 PE=4 SV=1 CANONICAL=A0AAA9S6X0-1" }, "locus": { "chromosome": "X", "start_pos": 134949070, "end_pos": 134903995, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115309.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115309.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089247.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089247.1" } ] } }, { "isoform_ac": "A0AAA9T2S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0/entry#A0AAA9T2S5-1", "sequence": { "sequence": "MFQKTDSLPTEPQGKPKNTGVSSLSLLQGIFPTQESNRGLAHIEARMKHINLSFAACGFLGIYHLGAASALYNHGRKLLKDVKACAGASAGSLVASVLLTAPQKIEECNKFTYDFAEEIRRQSFGALTPGYDFMARLRSGVESILPANAHELAHGRLHVSITNTRTRRNCLVSSFPSREDLVKVLLASSFLPIYAGLKPVEYKGQRWVDGGFTNSLPVLPVGRTVTISPFSGRLDVCPQDKGRLHFYVSITNQEVLLSVANLVRLNRALSPPSRRTMELLYRRGFDDASRFLLKENWFE", "length": 299, "header": "tr|A0AAA9T2S5-1|A0AAA9T2S5_BOVIN Computationally mapped isoform of Patatin like phospholipase domain containing 4 OS=Bos taurus OX=9913 GN=PNPLA4 PE=4 SV=1 CANONICAL=A0AAA9S6X0-1" }, "locus": { "chromosome": "X", "start_pos": 134949070, "end_pos": 134905299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098710.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098710.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090752.1" } ] } }, { "isoform_ac": "G3X777-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0/entry#G3X777-1", "sequence": { "sequence": "MKHINLSFAACGFLGIYHLGAASALYNHGRKLLKDVKACAGASAGSLVASVLLTAPQKIEECNKFTYDFAEEIRRQSFGALTPGYDFMARLRSGVESILPANAHELAHGRLHVSITNTRTRRNCLVSSFPSREDLVKRWVDGGFTNSLPVLPVGRTVTISPFSGRLDVCPQDKGRLHFYVSITNQEVLLSVANLVRLNRALSPPSRRTMELLYRRGFDDASRFLLKENWFE", "length": 231, "header": "tr|G3X777-1|G3X777_BOVIN Computationally mapped isoform of Patatin like phospholipase domain containing 4 OS=Bos taurus OX=9913 GN=PNPLA4 PE=4 SV=3 CANONICAL=A0AAA9S6X0-1" }, "locus": { "chromosome": "X", "start_pos": 134949070, "end_pos": 134906293, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021067.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021067.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021067.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021067.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-163560", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163560", "resource": "Reactome", "description": "Triglyceride catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" }, { "name": "triglyceride catabolic process", "id": "GO:0019433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019433", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "triacylglycerol lipase activity", "id": "GO:0004806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004806", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" }, { "name": "retinyl-palmitate esterase activity", "id": "GO:0050253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050253", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X0" }, { "id": "PS51635", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51635" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PNPLA", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 229, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6Y3-1", "uniprot_ac": "A0AAA9S6Y3", "uniprot_id": "A0AAA9S6Y3_BOVIN", "mass": { "chemical_mass": 6688.0, "monoisotopic_mass": 6688.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S6Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y3", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6Y3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6Y3", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9S6Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCDCGGEGTPGRCYHPLPSRVPAGACDLMSTGGRPSAPPQQSSCKIRWSKLLANLDPSLQCKR", "length": 63, "header": "tr|A0AAA9S6Y3-1|A0AAA9S6Y3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9S6Y3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y3/entry#A0AAA9S6Y3-1", "sequence": { "sequence": "MCDCGGEGTPGRCYHPLPSRVPAGACDLMSTGGRPSAPPQQSSCKIRWSKLLANLDPSLQCKR", "length": 63, "header": "tr|A0AAA9S6Y3-1|A0AAA9S6Y3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9S6Y3-1" }, "locus": { "chromosome": "4", "start_pos": 76613383, "end_pos": 76611363, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092966.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092966.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081755.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 9, "start_aa": "Thr", "end_pos": 9, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr9", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 9 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S706-1", "uniprot_ac": "A0AAA9S706", "uniprot_id": "A0AAA9S706_BOVIN", "mass": { "chemical_mass": 36864.0, "monoisotopic_mass": 36864.0 }, "refseq": {}, "gene_names": [ { "name": "CASP7", "type": "recommended", "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ] } ], "protein_names": [ { "name": "Caspase-3", "type": "recommended", "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706/entry#names_and_taxonomy" } ] }, { "name": "3.4.22.56", "type": "synonym", "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CASP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706", "locus": { "chromosome": "26", "start_pos": 34187652, "end_pos": 34146858, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006615", "url": "https://www.ensembl.org/id/ENSBTAG00000006615" } ] } } ], "crossref": [ { "id": "A0AAA9S706", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S706", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006615", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006615", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00032", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00032", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10454:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10454:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00656", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00656", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-111459", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111459", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-111463", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111463", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-111464", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111464", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-111465", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111465", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-111469", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111469", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-264870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S706-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD58", "url": "https://www.uniprot.org/uniprotkb/F1MD58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD58-1", "url": "https://www.uniprot.org/uniprotkb/F1MD58-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADDQGHIVEQGAEDPANNDTVDAKPDRSSFVSSIFREEGNSLPVIAGRSVVLMQRGVLSDGDMSKKKKNDSGKSVNIPRDRVPTYQYNMNFEKVGKCIIINNKNFDRITGMGVRNGTDKDAEALFKCFRSLGFDVSVYNDCSCAKMQDLLKKASEEDHRNSACFACILLSHGEENLIYGTDGKTAIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRNPGSGSWFVQALCSILNEHGKSLEILQILTRVNDRVARHFESQSDDPRFHEKKQIPCVVSMLTKELYF", "length": 329, "header": "tr|A0AAA9S706-1|A0AAA9S706_BOVIN Isoform 1 of Caspase-3 OS=Bos taurus OX=9913 GN=CASP7 PE=3 SV=1 CANONICAL=A0AAA9S706-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S706-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706/entry#A0AAA9S706-1", "sequence": { "sequence": "MADDQGHIVEQGAEDPANNDTVDAKPDRSSFVSSIFREEGNSLPVIAGRSVVLMQRGVLSDGDMSKKKKNDSGKSVNIPRDRVPTYQYNMNFEKVGKCIIINNKNFDRITGMGVRNGTDKDAEALFKCFRSLGFDVSVYNDCSCAKMQDLLKKASEEDHRNSACFACILLSHGEENLIYGTDGKTAIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRNPGSGSWFVQALCSILNEHGKSLEILQILTRVNDRVARHFESQSDDPRFHEKKQIPCVVSMLTKELYF", "length": 329, "header": "tr|A0AAA9S706-1|A0AAA9S706_BOVIN Isoform 1 of Caspase-3 OS=Bos taurus OX=9913 GN=CASP7 PE=3 SV=1 CANONICAL=A0AAA9S706-1" }, "locus": { "chromosome": "26", "start_pos": 34186648, "end_pos": 34153770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080977.1" } ] } }, { "isoform_ac": "F1MD58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706/entry#F1MD58-1", "sequence": { "sequence": "MDIWITPCLGLLLNSTAVHTRGSVLSKKKKNDSGKSVNIPRDRVPTYQYNMNFEKVGKCIIINNKNFDRITGMGVRNGTDKDAEALFKCFRSLGFDVSVYNDCSCAKMQDLLKKASEEDHRNSACFACILLSHGEENLIYGTDGKTAIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRNPGSGSWFVQALCSILNEHGKSLEILQILTRVNDRVARHFESQSDDPRFHEKKQIPCVVSMLTKELYF", "length": 290, "header": "tr|F1MD58-1|A0AAA9S706_BOVIN Computationally mapped isoform of Caspase-3 OS=Bos taurus OX=9913 GN=CASP7 PE=3 SV=4 CANONICAL=A0AAA9S706-1" }, "locus": { "chromosome": "26", "start_pos": 34186648, "end_pos": 34178788, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008706.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008706.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008706.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008706.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-111459", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111459", "resource": "Reactome", "description": "Activation of caspases through apoptosome-mediated cleavage" }, { "id": "R-BTA-111463", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111463", "resource": "Reactome", "description": "SMAC (DIABLO) binds to IAPs" }, { "id": "R-BTA-111464", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111464", "resource": "Reactome", "description": "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes" }, { "id": "R-BTA-111465", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111465", "resource": "Reactome", "description": "Apoptotic cleavage of cellular proteins" }, { "id": "R-BTA-111469", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111469", "resource": "Reactome", "description": "SMAC, XIAP-regulated apoptotic response" }, { "id": "R-BTA-264870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264870", "resource": "Reactome", "description": "Caspase-mediated cleavage of cytoskeletal proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "execution phase of apoptosis", "id": "GO:0097194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097194", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "cellular response to staurosporine", "id": "GO:0072734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "lymphocyte apoptotic process", "id": "GO:0070227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" }, { "name": "positive regulation of neuron apoptotic process", "id": "GO:0043525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S706", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-114261", "name": "Cleavage of Procaspase-7 by the apoptosome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S706-1", "A0ABI0NI58-1", "E1BNU2-1" ], "evidence": [ { "id": "R-BTA-114261", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114261" } ] }, { "id": "R-BTA-114354", "name": "SMAC binds XIAP:Caspase-7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S706-1", "A0ABI0NI58-1" ], "evidence": [ { "id": "R-BTA-114354", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114354" } ] }, { "id": "R-BTA-114392", "name": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S706-1", "A0ABI0NI58-1" ], "evidence": [ { "id": "R-BTA-114392", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114392" } ] }, { "id": "R-BTA-201628", "name": "Caspase-mediated cleavage of vimentin at DSVD (85)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-BTA-350264", "R-BTA-350294" ], "enzyme_list": [ "A0AAA9S706-1", "F1MB04-1" ], "evidence": [ { "id": "R-BTA-201628", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201628" } ] }, { "id": "R-BTA-201634", "name": "Caspase-mediated cleavage of FADK 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-BTA-202827", "R-BTA-202829" ], "enzyme_list": [ "A0AAA9S706-1" ], "evidence": [ { "id": "R-BTA-201634", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201634" } ] }, { "id": "R-BTA-201639", "name": "Caspase-mediated cleavage of GAS2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-201614" ], "output_participant_list": [ "R-BTA-202833", "R-BTA-202887" ], "enzyme_list": [ "A0AAA9S706-1", "F1MB04-1" ], "evidence": [ { "id": "R-BTA-201639", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201639" } ] }, { "id": "R-BTA-351901", "name": "Caspase-mediated cleavage of MST3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-351829" ], "output_participant_list": [ "R-BTA-351892", "R-BTA-351898" ], "enzyme_list": [ "A0AAA9S706-1", "F1MB04-1" ], "evidence": [ { "id": "R-BTA-351901", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351901" } ] }, { "id": "R-BTA-351936", "name": "Caspase-mediated cleavage of claspin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-176282" ], "output_participant_list": [ "R-BTA-351929", "R-BTA-351935" ], "enzyme_list": [ "A0AAA9S706-1" ], "evidence": [ { "id": "R-BTA-351936", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351936" } ] }, { "id": "R-BTA-9029680", "name": "Caspase-7 translocates to the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S706-1" ], "evidence": [ { "id": "R-BTA-9029680", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9029680" } ] }, { "id": "R-BTA-9627107", "name": "XIAP binds CASP7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S706-1", "A0ABI0NI58-1" ], "evidence": [ { "id": "R-BTA-9627107", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9627107" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-176282", "participant_name": "CLSPN [nucleoplasm]", "crossref": [ { "id": "A0A3Q1LF69", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000002826", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000056728", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000074281", "database": "ENSEMBL", "url": "" }, { "id": "27465", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-201614", "participant_name": "GAS2 [cytosol]", "crossref": [ { "id": "A8E4Q5", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000021654", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000081820", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000099511", "database": "ENSEMBL", "url": "" }, { "id": "XP_024843088.1", "database": "RefSeq", "url": "" }, { "id": "XP_005226789.1", "database": "RefSeq", "url": "" }, { "id": "XP_005226790.1", "database": "RefSeq", "url": "" }, { "id": "XP_024843087.1", "database": "RefSeq", "url": "" }, { "id": "NP_001098471.1", "database": "RefSeq", "url": "" }, { "id": "29257", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-202827", "participant_name": "PTK2(1-772) [cytosol]", "crossref": [ { "id": "A0A3Q1MAA1", "database": "UniProt", "url": "" }, { "id": "33518", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-202829", "participant_name": "PTK2(773-1052) [cytosol]", "crossref": [ { "id": "33518", "database": "VGNC", "url": "" }, { "id": "A0A3Q1MAA1", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-BTA-202833", "participant_name": "GAS2(1-279) [cytosol]", "crossref": [ { "id": "XP_005226790.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000081820", "database": "ENSEMBL", "url": "" }, { "id": "NP_001098471.1", "database": "RefSeq", "url": "" }, { "id": "XP_024843088.1", "database": "RefSeq", "url": "" }, { "id": "A8E4Q5", "database": "UniProt", "url": "" }, { "id": "XP_005226789.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000021654", "database": "ENSEMBL", "url": "" }, { "id": "29257", "database": "VGNC", "url": "" }, { "id": "XP_024843087.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAT00000099511", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-202887", "participant_name": "GAS2(280-313) [cytosol]", "crossref": [ { "id": "NP_001098471.1", "database": "RefSeq", "url": "" }, { "id": "XP_024843088.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000081820", "database": "ENSEMBL", "url": "" }, { "id": "XP_005226790.1", "database": "RefSeq", "url": "" }, { "id": "A8E4Q5", "database": "UniProt", "url": "" }, { "id": "XP_005226789.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000021654", "database": "ENSEMBL", "url": "" }, { "id": "29257", "database": "VGNC", "url": "" }, { "id": "XP_024843087.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAT00000099511", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-350264", "participant_name": "VIM [cytosol]", "crossref": [ { "id": "36796", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000018463", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000024572", "database": "ENSEMBL", "url": "" }, { "id": "P48616", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000024572", "database": "ENSEMBL", "url": "" }, { "id": "NP_776394.2", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-350294", "participant_name": "VIM [cytosol]", "crossref": [ { "id": "ENSBTAT00000024572", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000018463", "database": "ENSEMBL", "url": "" }, { "id": "36796", "database": "VGNC", "url": "" }, { "id": "P48616", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000024572", "database": "ENSEMBL", "url": "" }, { "id": "NP_776394.2", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-351829", "participant_name": "STK24 [cytosol]", "crossref": [ { "id": "A2VE07", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000032234", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000071705", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000075747", "database": "ENSEMBL", "url": "" }, { "id": "NP_001093420.1", "database": "RefSeq", "url": "" }, { "id": "35390", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-351892", "participant_name": "STK24(1-325) [cytosol]", "crossref": [ { "id": "NP_001093420.1", "database": "RefSeq", "url": "" }, { "id": "A2VE07", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000071705", "database": "ENSEMBL", "url": "" }, { "id": "35390", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000075747", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000032234", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-351898", "participant_name": "STK24(326-443) [cytosol]", "crossref": [ { "id": "ENSBTAT00000075747", "database": "ENSEMBL", "url": "" }, { "id": "35390", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000032234", "database": "ENSEMBL", "url": "" }, { "id": "A2VE07", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000071705", "database": "ENSEMBL", "url": "" }, { "id": "NP_001093420.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-351929", "participant_name": "CLSPN [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000074281", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000002826", "database": "ENSEMBL", "url": "" }, { "id": "27465", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000056728", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1LF69", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-BTA-351935", "participant_name": "CLSPN [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000074281", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000002826", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1LF69", "database": "UniProt", "url": "" }, { "id": "27465", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000056728", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S706", "gene_name": "CASP7", "activity": [ { "ec_number": "3.4.22.56", "activity": "Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.", "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ] }, { "ec_number": "3.4.22.56", "activity": "", "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" } ] } ] }, { "uniprot_ac": "A0ABI0NI58", "gene_name": "XIAP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0ABI0NI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NI58" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0ABI0NI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NI58" } ] } ] }, { "uniprot_ac": "E1BNU2", "gene_name": "CASP9", "activity": [ { "ec_number": "3.4.22.62", "activity": "Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa.", "evidence": [ { "id": "E1BNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNU2" } ] }, { "ec_number": "3.4.22.62", "activity": "", "evidence": [ { "id": "E1BNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNU2" } ] } ] }, { "uniprot_ac": "F1MB04", "gene_name": "CASP3", "activity": [ { "ec_number": "3.4.22.56", "activity": "Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.", "evidence": [ { "id": "F1MB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB04" } ] }, { "ec_number": "3.4.22.56", "activity": "", "evidence": [ { "id": "F1MB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB04" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" }, { "id": "PS50207", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50207" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Caspase family p10", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 329, "start_aa": "Pro", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S706" }, { "id": "PS50208", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50208" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Caspase family p20", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 218, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.22.56", "ec_name": "Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.", "evidence": [ { "id": "3.4.22.56", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.22.56" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S714-1", "uniprot_ac": "A0AAA9S714", "uniprot_id": "A0AAA9S714_BOVIN", "mass": { "chemical_mass": 49750.0, "monoisotopic_mass": 49750.0 }, "refseq": { "ac": "XP_002688113", "name": "translocating chain-associated membrane protein 1-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688113" }, "gene_names": [ { "name": "TRAM1L1", "type": "recommended", "evidence": [ { "id": "A0AAA9S714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714" } ] }, { "name": "TRAM1L1", "type": "synonym", "evidence": [ { "id": "XP_002688113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688113" } ] } ], "protein_names": [ { "name": "Translocation associated membrane protein 1 like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714/entry#names_and_taxonomy" } ] }, { "name": "translocating chain-associated membrane protein 1-like 1", "type": "synonym", "evidence": [ { "id": "XP_002688113", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688113" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S714", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAM1L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714", "locus": { "chromosome": "6", "start_pos": 8278113, "end_pos": 8232696, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064164", "url": "https://www.ensembl.org/id/ENSBTAG00000064164" } ] } } ], "crossref": [ { "id": "505068", "url": "https://www.ncbi.nlm.nih.gov/gene/505068", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505068", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505068", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12371", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12371", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12371:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12371:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688113", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688113", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S714", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S714-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSLARPNAVIDFFLGGRDDLGPAPGWGVKPLEPPQPLLRRREEQPQGGSCRSSVSSRTATMTFRKKGSKNPPLLSLEFILQNHADFVACVGMFFVLGLMFEGTAEVSIVFITLQHGVTFPAAEAEAEAEAERATAPKFLYHYGAKDLATVFFYTLVAIIIHATIQEYVLDRINRRMQFPKQRQGKFYESGQFSVFFLVSCIWGTFILVSENCLSDLAVLWKAHTHNMMTFQMKFFYISQLAYWFHAFPELLFQRSRPQELSQQAVYVGLHLFHIAGAYLLYLNHLGLLLLMMHYFVEFLSHSCDLFYFSDEKFQKEFSLWAIVFILGRLVTLIVSLITAGFQLAGGHNVISDDSAEDVNVLAAKIAVLSSSCSIQAYVTWNLFNVQLQRWMEEDAPLQAPSVKKKRIKGRFCRKGTENGVATSNRLLDSPQMRKEKSS", "length": 439, "header": "tr|A0AAA9S714-1|A0AAA9S714_BOVIN Isoform 1 of Translocation associated membrane protein 1 like 1 OS=Bos taurus OX=9913 GN=TRAM1L1 PE=3 SV=1 CANONICAL=A0AAA9S714-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S714-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714/entry#A0AAA9S714-1", "sequence": { "sequence": "MLSLARPNAVIDFFLGGRDDLGPAPGWGVKPLEPPQPLLRRREEQPQGGSCRSSVSSRTATMTFRKKGSKNPPLLSLEFILQNHADFVACVGMFFVLGLMFEGTAEVSIVFITLQHGVTFPAAEAEAEAEAERATAPKFLYHYGAKDLATVFFYTLVAIIIHATIQEYVLDRINRRMQFPKQRQGKFYESGQFSVFFLVSCIWGTFILVSENCLSDLAVLWKAHTHNMMTFQMKFFYISQLAYWFHAFPELLFQRSRPQELSQQAVYVGLHLFHIAGAYLLYLNHLGLLLLMMHYFVEFLSHSCDLFYFSDEKFQKEFSLWAIVFILGRLVTLIVSLITAGFQLAGGHNVISDDSAEDVNVLAAKIAVLSSSCSIQAYVTWNLFNVQLQRWMEEDAPLQAPSVKKKRIKGRFCRKGTENGVATSNRLLDSPQMRKEKSS", "length": 439, "header": "tr|A0AAA9S714-1|A0AAA9S714_BOVIN Isoform 1 of Translocation associated membrane protein 1 like 1 OS=Bos taurus OX=9913 GN=TRAM1L1 PE=3 SV=1 CANONICAL=A0AAA9S714-1" }, "locus": { "chromosome": "6", "start_pos": 8274899, "end_pos": 8273583, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130002.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130002.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081790.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081790.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505068", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505068", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S714", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SRP-dependent cotranslational protein targeting to membrane, translocation", "id": "GO:0006616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S714", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S714" }, { "id": "SM00724", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00724" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TLC", "eco_id": "ECO_0000259", "start_pos": 185, "end_pos": 394, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S718-1", "uniprot_ac": "A0AAA9S718", "uniprot_id": "A0AAA9S718_BOVIN", "mass": { "chemical_mass": 36746.0, "monoisotopic_mass": 36746.0 }, "refseq": { "ac": "XP_002687818", "name": "ecto-ADP-ribosyltransferase 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687818" }, "gene_names": [ { "name": "ART4", "type": "recommended", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] }, { "name": "SMCO3", "type": "recommended", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] }, { "name": "ART4", "type": "synonym", "evidence": [ { "id": "XP_002687818", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687818" } ] }, { "name": "SMCO3", "type": "synonym", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] } ], "protein_names": [ { "name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#names_and_taxonomy" } ] }, { "name": "2.4.2.31", "type": "synonym", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#names_and_taxonomy" } ] }, { "name": "Mono(ADP-ribosyl)transferase", "type": "synonym", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#names_and_taxonomy" } ] }, { "name": "ecto-ADP-ribosyltransferase 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687818", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687818" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S718", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMCO3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718", "locus": {} } ], "crossref": [ { "id": "A0AAA9S718", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S718", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008352", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008352", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000026610", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026610", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "407146", "url": "https://www.ncbi.nlm.nih.gov/gene/407146", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "618483", "url": "https://www.ncbi.nlm.nih.gov/gene/618483", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407146", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407146", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:618483", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618483", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HSFHFKY", "url": "https://omabrowser.org/oma/group/HSFHFKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "MSTNFHA", "url": "https://omabrowser.org/oma/group/MSTNFHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N030", "url": "https://www.orthodb.org/?gene=G3N030", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10339:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10339:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35972:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35972:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687818", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687818", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19149", "url": "https://www.rhea-db.org/rhea/19149", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S718", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S718-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAP9", "url": "https://www.uniprot.org/uniprotkb/E1BAP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N030", "url": "https://www.uniprot.org/uniprotkb/G3N030", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N030-1", "url": "https://www.uniprot.org/uniprotkb/G3N030-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELRGQRNALHTNKCCPLTNHCRRILLANTAASAVRIWLLRGQLLLLLLCSGLQRPTIAVKIDFDLTPNSFDDQYRGCSQQVMEMLLQGDYFMEELESSKHYRKVWHQTHLNWLNQEKPLPGNMTITHALAVSVYLSDDRVHLDFSRAMASAAGSPQQYKHSFRFKYLHYFLTSAIQLLRKEIVSRKDSLCYEVQHELKGVYLRAPVGSIVRFGQFLSTSPAREQAQRFGNQTLFTMLTCLGAPVQDFSLKKEVLVPPYELFKVVNVSYHPRGNWLQLLSNGTQSTYNCQLLKASSRKCIPTPLVVASLSFLTSVIIFSKSGA", "length": 323, "header": "tr|A0AAA9S718-1|A0AAA9S718_BOVIN Isoform 1 of NAD(P)(+)--arginine ADP-ribosyltransferase OS=Bos taurus OX=9913 GN=SMCO3 PE=3 SV=1 CANONICAL=A0AAA9S718-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S718-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#A0AAA9S718-1", "sequence": { "sequence": "MELRGQRNALHTNKCCPLTNHCRRILLANTAASAVRIWLLRGQLLLLLLCSGLQRPTIAVKIDFDLTPNSFDDQYRGCSQQVMEMLLQGDYFMEELESSKHYRKVWHQTHLNWLNQEKPLPGNMTITHALAVSVYLSDDRVHLDFSRAMASAAGSPQQYKHSFRFKYLHYFLTSAIQLLRKEIVSRKDSLCYEVQHELKGVYLRAPVGSIVRFGQFLSTSPAREQAQRFGNQTLFTMLTCLGAPVQDFSLKKEVLVPPYELFKVVNVSYHPRGNWLQLLSNGTQSTYNCQLLKASSRKCIPTPLVVASLSFLTSVIIFSKSGA", "length": 323, "header": "tr|A0AAA9S718-1|A0AAA9S718_BOVIN Isoform 1 of NAD(P)(+)--arginine ADP-ribosyltransferase OS=Bos taurus OX=9913 GN=SMCO3 PE=3 SV=1 CANONICAL=A0AAA9S718-1" }, "locus": { "chromosome": "5", "start_pos": 95082132, "end_pos": 95068782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108685.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108685.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079705.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079705.1" } ] } }, { "isoform_ac": "A0AAA9SZ11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#A0AAA9SZ11-1", "sequence": { "sequence": "MELRGQRNALHTNKCCPLTNHCRRILLANTAASAVRIWLLRGQLLLLLLCSGLQRPTIAVKIDFDLTPNSFDDQYRGCSQQVMEMLLQGDYFMEELESSKHYRKVWHQTHLNWLNQEKPLPGNMTITHALAVSVYLSDDRVHLDFSRAMASAAGSPQQYKHSFRFKYLHYFLTSAIQLLRKEIVSRKDSLCYEVQHELKGVYLRAPVGSIVRFGQFLSTSPAREQAQRFGNQTLFTMLTCLGAPVQDFSLKKEVLVPPYELFKVVNVSYHPRGNWLQLLSNGTQSTYNCQLLKETILKYGSK", "length": 302, "header": "tr|A0AAA9SZ11-1|A0AAA9SZ11_BOVIN Computationally mapped isoform of NAD(P)(+)--arginine ADP-ribosyltransferase OS=Bos taurus OX=9913 GN=SMCO3 PE=3 SV=1 CANONICAL=A0AAA9S718-1" }, "locus": { "chromosome": "5", "start_pos": 95099162, "end_pos": 95068782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115590.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115590.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089323.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089323.1" } ] } }, { "isoform_ac": "A0AAA9TT67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#A0AAA9TT67-1", "sequence": { "sequence": "MELRGQRNALHTNKCCPLTNHCRRILLANTAASAVRIWLLRGQLLLLLLCSGLQRPTIAVKIDFDLTPNSFDDQYRGCSQQVMEMLLQGDYFMEELESSKHYRKVWHQTHLNWLNQEKPLPGNMTITHALAVSVYLSDDRVHLDFSRAMASAAGSPQQYKHSFRFKYLHYFLTSAIQLLRKEIVSRKDSLCYEVQHELKGVYLRAPVGSIVRFGQFLSTSPAREQAQRFGNQTLFTMLTCLGAPVQDFSLKKEVLVPPYELFKVVNVSYHPRGNWLQLLSNGTQSTYNCQLLKATVI", "length": 297, "header": "tr|A0AAA9TT67-1|A0AAA9TT67_BOVIN Computationally mapped isoform of NAD(P)(+)--arginine ADP-ribosyltransferase OS=Bos taurus OX=9913 GN=SMCO3 PE=3 SV=1 CANONICAL=A0AAA9S718-1" }, "locus": { "chromosome": "5", "start_pos": 95075612, "end_pos": 95068782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101560.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101560.1" } ] } }, { "isoform_ac": "E1BAP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#E1BAP9-1", "sequence": { "sequence": "MAQSDFLYPENPKRRQEVNRLHQELLDCLSDSFHATNKLIGVLNTHLGCTLPSIEMKREGTIKENCDIIIQAMMNIQKELQKVDEALKDKLEPTLYRKLQDIKERETEKIAIVQKVISVILGEATSAASAVAVKLVGSNVTTGIINKLVTVLAQIGASLLGSIGVAVLGLGIDMIIRAILGAVEKTQLQAAIKSYEKHLVEFKSASEKYHHAITEVTNTVKHQVK", "length": 225, "header": "tr|E1BAP9-1|E1BAP9_BOVIN Computationally mapped isoform of ADP-ribosyltransferase 4 OS=Bos taurus OX=9913 GN=SMCO3 PE=4 SV=2 CANONICAL=A0AAA9S718-1" }, "locus": { "chromosome": "5", "start_pos": 95099826, "end_pos": 95099152, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037882.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037882.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037704.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037704.4" } ] } }, { "isoform_ac": "G3N030-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718/entry#G3N030-1", "sequence": { "sequence": "MELRGQRNALHTNKCCPLTNHCRRILLANTAASAVRIWLLRGQLLLLLLCSGLQRPTIAVKIDFDLTPNSFDDQYRGCSQQVMEMLLQGDYFMEELESSKHYRKVWHQTHLNWLNQEKPLPGNMTITHALAVSVYLSDDRVHLDFSRAMASAAGSPQQYKHSFRFKYLHYFLTSAIQLLRKEIVSRKDSLCYEVQHELKGVYLRAPVGSIVRFGQFLSTSPAREQAQRFGNQTLFTMLTCLGAPVQDFSLKKEVLVPPYELFKVVNVSYHPRGNWLQLLSNGTQSTYNCQLLKGFSSLSCQEATIS", "length": 306, "header": "tr|G3N030-1|G3N030_BOVIN Computationally mapped isoform of NAD(P)(+)--arginine ADP-ribosyltransferase OS=Bos taurus OX=9913 GN=ART4 PE=3 SV=3 CANONICAL=A0AAA9S718-1" }, "locus": { "chromosome": "5", "start_pos": 95079942, "end_pos": 95068782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065211.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065211.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055185.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055185.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:407146", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407146", "resource": "KEGG Pathway" }, { "id": "bta:618483", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618483", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HZA4-1", "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "gene_name": "Art4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPKEGSGVRFGMWLSGQPWASDTHSSRCCPLTGRSKRRLLPSTEDRRMRRRLPGGQLTPLLLLLCALQAPAGSTKAALKVDLDLTPDSFDDQYQGCSKQVMEELSQGDYFMKEIDTHKYYSRAWQKAHLTWLNQEGTLPENMTTAHAVAILVYTSNRNVSSDFATAMARAGASPGQYRQSFHFKYLHYYLTSAIQLLRKESSTKNRDLCYEVHYGMKNVRFEVNVGATVRFGQFLSASLLREETRVSGNQTLFTMVTCLGTSVQDFSLRKEVLIPPYELFEVVNKSHSPKGELINLRSAGNLSTYNCQLIKASSKKCTPDPMVTICLFLVSVIISSKTREQRNPLAPS", "length": 348 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YL61-1", "protein_name": "Single-pass membrane protein with coiled-coil domains 3", "gene_name": "SMCO3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALSDLLYPENPRRRQELIHLHRELLDCMSMNFHATNELAGVLNAHLGCTITHIKMRESSTVKENCDIIIRAMHEIQCQVQKIDGDMKEKLEPVLYQKLYDIKEPELEKIAIAHKVFSIVLGEVTSTAGMVAVKLLSSNLITITVCKLISLLAQIGASVLGGISITILGLGMEMILHAILGAVERNQLLAAVRSYEEHLAEFKEASEKYQRAIHEVTSLVRHQVQ", "length": 225 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0L6I4-1", "protein_name": "Single-pass membrane protein with coiled-coil domains 3 like 1", "gene_name": "Smco3l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQSDFLYPQNPRRRQEVNRLHQQLLDCLSDCFQVTNKLTGLLNAHLGCRLAFIEMRSDETIKRNCDLIIQAVTKIQKELQKVDEALKDKLEPTLYRKLRDIKERETEKIAIVQKVISVILGEATAAASAVAVKLVGSNVTTGIISKLASVLTHIGTSILGSIGVAVLSLGIDMVVQAILGAVERTQLQSAIQSYEKHLTEFKAASEKYHHAIAEVTDAVKRQLR", "length": 225 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2RU48-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 3", "gene_name": "SMCO3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQSDFLYPENPKRREEVNRLHQQLLDCLSDSFDVTNKLTEVLNMHLGCRLASIEMKRDGTIKENCDLIIQAIMKIQKELQKVDEALKDKLEPTLYRKLQDIKEKETDKIAIVQKVISVILGEATSAASAVAVKLVGSNVTTGIINKLVTVLAQIGASLLGSIGVAVLGLGIDMIVRAILGAVEKTQLQAAIKSYEKHLVEFKSASEKYNHAITEVINTVKHQMK", "length": 225 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1MA10-1", "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "gene_name": "Art4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALWFPGGQLTLLLLPLLLLLLWVQQTPAGSAEAALKVDVDLTPGSFDDQYRGCSKQVLEELNQGDYFVREIDTHKYYSRAWQKAHLTWLNQATSLPESMTPVHAVAILVFTLNLNVSSDFAKAMTRASGSPGQYRQSFHFKYLHYYLTSAIQLLRKESSTKNGSPCYRVHHRMKDVNIEANVGSTVRFGQFLSASLLKEETQVSGNQTLFTIFTCLGASVQDFSLRKEVLIPPYELFEVVSKNCSLKGDLINLRSAGNVSRYNCQLLKASSKKCTPAPMVVLCLCLVSVLISSKSREHRNLPAPF", "length": 306 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SQV4-1", "protein_name": "Single-pass membrane protein with coiled-coil domains 3", "gene_name": "SMCO3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQSDFLYPENPRRRQEVNRLHQELLDCLSDSFQATNKLIGVLNMHLGCRLASIEMKRDGTIKENCDIIIQAMMKIQKELQKVDEALKDKLEPTLYRKLQDIKERETEKIAIVQKVISVILGEATSAASAVAVKLVGSNVTTGIINKLVTVLAQIGASLLGSIGVAVLGLGIDMIFRAILGAVEKTQLQAAIKSYEKHLVEFKSASEKYHHAITEVTNTVKHQMK", "length": 225 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H4P7-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 3", "gene_name": "Smco3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQSDFLYPENPRRRQEVNRLHQQLLDCLSDSFQVTNKLTGVLNTHLGCRLAFIEMKRDGTIKENCDIIIQAVVKIQKELQKVDEALKDKLEPTLYRKLQDIKERETEKMAIVQKVISVILGEATSAASAVAVKLLGSNVTTGIMNKLVTVLAHIGTSLLGSIGVAVLGLGIDIIFRAILGAVERSQLQAAIKSYEKHLVEFKAASERYHHAITEVTRAVTRQIR", "length": 225 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BQM7-1", "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 3", "gene_name": "Smco3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQSDFLYPQNPRRRQEVNRLHQQLLDCLSDSFQVTNKLTGVLNTHLGCRLAFIEMKSDGTIKENCDIIIQAMTKIQKELQKIDEALKDQLEPTLYRKLQDIKERETEKIAIVQKVISVILGEATSAASAVAVKLVGSSVTTGIISKLVSVLAHIGTSLLGSIGVAVLSLGIDMIIQAILGAVERTQLQAAIKSYEKHLEEFKAASAKYHHAITEVATAVKRQLR", "length": 225 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q93070-1", "protein_name": "Ecto-ADP-ribosyltransferase 4", "gene_name": "ART4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV", "length": 314 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CRA0-1", "protein_name": "Ecto-ADP-ribosyltransferase 4", "gene_name": "Art4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALWLPGGQLTLLLLLWVQQTPAGSTEAPLKVDVDLTPDSFDDQYQGCSEQMVEELNQGDYFIKEVDTHKYYSRAWQKAHLTWLNQAKALPESMTPVHAVAIVVFTLNLNVSSDLAKAMARAAGSPGQYSQSFHFKYLHYYLTSAIQLLRKDSSTKNGSLCYKVYHGMKDVSIGANVGSTIRFGQFLSASLLKEETRVSGNQTLFTIFTCLGASVQDFSLRKEVLIPPYELFEVVSKSGSPKGDLINLRSAGNMSTYNCQLLKACSKKCAPAPVVIGCLFLVTVVISSKSRAQRNLLAPF", "length": 300 }, "evidence": [ { "id": "A0AAA9S718", "url": "https://omabrowser.org/oma/group/A0AAA9S718/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "nucleotidyltransferase activity", "id": "GO:0016779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S718", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ], "pmid": "" }, { "name": "NAD+-protein-arginine ADP-ribosyltransferase activity", "id": "GO:0106274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106274", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S718", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ], "pmid": "" }, { "name": "NAD+ poly-ADP-ribosyltransferase activity", "id": "GO:0003950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003950", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S718", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19149", "name": "", "equation": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6RR68-1", "E1BAP6-1", "E1BI74-1", "A0AAA9S718-1", "A0A3Q1MF93-1", "F1MHV9-1", "Q0VC22-1", "A0A3Q1MZC4-1", "A0AAA9SJA1-1" ], "evidence": [ { "id": "19149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19149" } ] }, { "id": "R-BTA-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2197633" ], "enzyme_list": [ "F1MLP3-1", "A0A3Q1LSG5-1", "P09487-1", "E1B735-1", "A0AAA9S718-1", "F1MNM2-1", "F1MPH8-1", "A0A140T891-1", "A0A3Q1MCB1-1", "E1BJE3-1" ], "evidence": [ { "id": "R-BTA-8940388", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8940388" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2197633", "participant_name": "PI [extracellular region]", "crossref": [ { "id": "57880", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T891", "gene_name": "VNN1", "activity": [ { "ec_number": "3.5.1.92", "activity": "(R)-pantetheine + H2O = cysteamine + (R)-pantothenate.", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] }, { "ec_number": "3.5.1.92", "activity": "", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] } ] }, { "uniprot_ac": "A0A3Q1LSG5", "gene_name": "LOC100125266", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] } ] }, { "uniprot_ac": "A0A3Q1MCB1", "gene_name": "", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MF93", "gene_name": "LOC112441637", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "A0A3Q1MF93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF93" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MF93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF93" } ] } ] }, { "uniprot_ac": "A0A3Q1MZC4", "gene_name": "", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "A0A3Q1MZC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZC4" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MZC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZC4" } ] } ] }, { "uniprot_ac": "A0AAA9S718", "gene_name": "SMCO3", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] } ] }, { "uniprot_ac": "A0AAA9SJA1", "gene_name": "SIRT6", "activity": [ { "ec_number": "2.3.1.286", "activity": "N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein].", "evidence": [ { "id": "A0AAA9SJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA1" } ] }, { "ec_number": "2.3.1.286", "activity": "", "evidence": [ { "id": "A0AAA9SJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA1" } ] } ] }, { "uniprot_ac": "E1B735", "gene_name": "XPNPEP2", "activity": [ { "ec_number": "3.4.11.9", "activity": "Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] }, { "ec_number": "3.4.11.9", "activity": "", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] } ] }, { "uniprot_ac": "E1BAP6", "gene_name": "", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "E1BAP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP6" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "E1BAP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP6" } ] } ] }, { "uniprot_ac": "E1BI74", "gene_name": "", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "E1BI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI74" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "E1BI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI74" } ] } ] }, { "uniprot_ac": "E1BJE3", "gene_name": "LOC516378", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "E1BJE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE3" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "E1BJE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE3" } ] } ] }, { "uniprot_ac": "F1MHV9", "gene_name": "LOC618664", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "F1MHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHV9" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "F1MHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHV9" } ] } ] }, { "uniprot_ac": "F1MLP3", "gene_name": "BST1", "activity": [ { "ec_number": "3.2.2.6", "activity": "NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+).", "evidence": [ { "id": "F1MLP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP3" } ] }, { "ec_number": "3.2.2.6", "activity": "", "evidence": [ { "id": "F1MLP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP3" } ] } ] }, { "uniprot_ac": "F1MNM2", "gene_name": "GPLD1", "activity": [ { "ec_number": "3.1.4.50", "activity": "[protein]-C-terminal carboxyl phosphoethanolamide-(1-radyl-2-octadecanoyl)-GPI(deacylinositol-H7) + H2O = [protein]-C-terminal carboxyl phosphoethanolamide-glycosylinositol (deacylinositol-H7) + 1-radyl-2-octadecanoyl-sn-glycero-3-phosphate + H(+).", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] }, { "ec_number": "3.1.4.50", "activity": "", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] } ] }, { "uniprot_ac": "F1MPH8", "gene_name": "LOC528262", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1MPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPH8" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F1MPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPH8" } ] } ] }, { "uniprot_ac": "F6RR68", "gene_name": "ART1", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "F6RR68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RR68" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "F6RR68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RR68" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "Q0VC22", "gene_name": "ART5", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "Q0VC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC22" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "Q0VC22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC22" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.2.31", "ec_name": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "2.4.2.31", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31" }, { "id": "2.4.2.31", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.31" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 266, "end_pos": 268 }, { "start_pos": 281, "end_pos": 283 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S719-1", "uniprot_ac": "A0AAA9S719", "uniprot_id": "A0AAA9S719_BOVIN", "mass": { "chemical_mass": 46748.0, "monoisotopic_mass": 46748.0 }, "refseq": { "ac": "XP_059745685", "name": "nucleoporin Nup43 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745685" }, "gene_names": [ { "name": "NUP43", "type": "recommended", "evidence": [ { "id": "A0AAA9S719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719" } ] }, { "name": "NUP43", "type": "synonym", "evidence": [ { "id": "XP_059745685", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745685" } ] } ], "protein_names": [ { "name": "Nucleoporin 43", "type": "synonym", "evidence": [ { "id": "A0AAA9S719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719/entry#names_and_taxonomy" } ] }, { "name": "nucleoporin Nup43 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059745685", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745685" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S719", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUP43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719", "locus": { "chromosome": "9", "start_pos": 86902280, "end_pos": 86917838, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010196", "url": "https://www.ensembl.org/id/ENSBTAG00000010196" } ] } } ], "crossref": [ { "id": "A0AAA9S719", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S719", "database": "AlphaFoldDB", "categories": [] }, { "id": "520174", "url": "https://www.ncbi.nlm.nih.gov/gene/520174", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22652:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22652:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059745685", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745685", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S719", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S719-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T446", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T446", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T446-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T446-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLS4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLQHKDWHAFALVQSRLDEEGRRIFFAIGAGLFVPALPTEENWLSAATVPHKKISKTRWRPLPPGSLQTAETFATGSWDNEENYVSMWSIGDFGNLDSDGGFEGDHQLLCSIKHHGDVMDLQFLDQERIVAASSTGCVTIFLHHPNNQTLSASQQWTAAHYHTGPGSPSCSNAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQRNEPTQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPDHLFTCSEDGSLWHWDASTDGPEKSSLFHQGGRNSTFLSHTISNQANVHQSLISSWLSTDPAKDRIEITSLLPNRTLSVNSLDVLGPCLVCGTDAEAIYVTRQLFS", "length": 422, "header": "tr|A0AAA9S719-1|A0AAA9S719_BOVIN Isoform 1 of Nucleoporin 43 OS=Bos taurus OX=9913 GN=NUP43 PE=4 SV=1 CANONICAL=A0AAA9S719-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S719-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719/entry#A0AAA9S719-1", "sequence": { "sequence": "MVLQHKDWHAFALVQSRLDEEGRRIFFAIGAGLFVPALPTEENWLSAATVPHKKISKTRWRPLPPGSLQTAETFATGSWDNEENYVSMWSIGDFGNLDSDGGFEGDHQLLCSIKHHGDVMDLQFLDQERIVAASSTGCVTIFLHHPNNQTLSASQQWTAAHYHTGPGSPSCSNAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQRNEPTQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPDHLFTCSEDGSLWHWDASTDGPEKSSLFHQGGRNSTFLSHTISNQANVHQSLISSWLSTDPAKDRIEITSLLPNRTLSVNSLDVLGPCLVCGTDAEAIYVTRQLFS", "length": 422, "header": "tr|A0AAA9S719-1|A0AAA9S719_BOVIN Isoform 1 of Nucleoporin 43 OS=Bos taurus OX=9913 GN=NUP43 PE=4 SV=1 CANONICAL=A0AAA9S719-1" }, "locus": { "chromosome": "9", "start_pos": 86917838, "end_pos": 86904331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103497.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103497.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081795.1" } ] } }, { "isoform_ac": "A0AAA9T446-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719/entry#A0AAA9T446-1", "sequence": { "sequence": "MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYVSMWSIGDFGNLDSDGGFEGDHQLLCSIKHHGDVMDLQFLDQERIVAASSTGCVTIFLHHPNNQTLSASQQWTAAHYHTGPGSPSCSNAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIVWEVHFHPSNPDHLFTCSEDGSLWHWDASTDGPEKSSLFHQGGRNSTFLSHTISNQANVHQSLISSWLSTDPAKDRIEITSLLPNRTLSVNSLDVLGPCLVCGTDAEAIYVTRQLFS", "length": 284, "header": "tr|A0AAA9T446-1|A0AAA9T446_BOVIN Computationally mapped isoform of Nucleoporin 43 OS=Bos taurus OX=9913 GN=NUP43 PE=4 SV=1 CANONICAL=A0AAA9S719-1" }, "locus": { "chromosome": "9", "start_pos": 86917590, "end_pos": 86904331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107799.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107799.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092566.1" } ] } }, { "isoform_ac": "A0AAF6DLS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719/entry#A0AAF6DLS4-1", "sequence": { "sequence": "MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYVSMWSIGDFGNLDSDGGFEGDHQLLCSIKHHGDVMDLQFLDQERIVAASSTGCVTIFLHHPNNQTLSASQQWTAAHYHTGPGSPSCSNAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQRNEPTQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAETIWSIILCLLFDTEAIDFITGLEFEVWEVHFHPSNPDHLFTCSEDGSLWHWDASTDGPEKSSLFHQGGRNSTFLSHTISNQANVHQSLISSWLSTDPAKDRIEITSLLPNRTLSVNSLDVLGPCLVCGTDAEAIYVTRQLFS", "length": 405, "header": "tr|A0AAF6DLS4-1|A0AAF6DLS4_BOVIN Computationally mapped isoform of Nucleoporin 43 OS=Bos taurus OX=9913 GN=NUP43 PE=4 SV=1 CANONICAL=A0AAA9S719-1" }, "locus": { "chromosome": "9", "start_pos": 86917590, "end_pos": 86904331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045398.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045398.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042789.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042789.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nuclear pore outer ring", "id": "GO:0031080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S719", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S719", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S719", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S719", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S719" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 390, "end_pos": 392 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S745-1", "uniprot_ac": "A0AAA9S745", "uniprot_id": "A0AAA9S745_BOVIN", "mass": { "chemical_mass": 43529.0, "monoisotopic_mass": 43529.0 }, "refseq": {}, "gene_names": [ { "name": "CTDSPL", "type": "recommended", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ], "protein_names": [ { "name": "protein-serine/threonine phosphatase", "type": "recommended", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S745", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTDSPL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745", "locus": { "chromosome": "22", "start_pos": 11430280, "end_pos": 11307348, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053223", "url": "https://www.ensembl.org/id/ENSBTAG00000053223" } ] } } ], "crossref": [ { "id": "A0AAA9S745", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S745", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053223", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053223", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07521", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07521", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538425", "url": "https://www.ncbi.nlm.nih.gov/gene/538425", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538425", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538425", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12210", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12210", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S745", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S745-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB22", "url": "https://www.uniprot.org/uniprotkb/F1MB22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB22-1", "url": "https://www.uniprot.org/uniprotkb/F1MB22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "PPAALPRPLAYWSSSERPFQVARRRRGSETAPGPSKCEGALWLHASALALAPGLTVAACSSEVQSLLSSAATGPLLSSAFHSLPRLGPLLQSTRKCPFSRSRLTPRARRLVPEDPQSSTRALEADAEVTNPKEDEGRAPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 394, "header": "tr|A0AAA9S745-1|A0AAA9S745_BOVIN Isoform 1 of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=1 CANONICAL=A0AAA9S745-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S745-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#A0AAA9S745-1", "sequence": { "sequence": "PPAALPRPLAYWSSSERPFQVARRRRGSETAPGPSKCEGALWLHASALALAPGLTVAACSSEVQSLLSSAATGPLLSSAFHSLPRLGPLLQSTRKCPFSRSRLTPRARRLVPEDPQSSTRALEADAEVTNPKEDEGRAPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 394, "header": "tr|A0AAA9S745-1|A0AAA9S745_BOVIN Isoform 1 of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=1 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11430266, "end_pos": 11307350, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125502.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125502.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081821.1" } ] } }, { "isoform_ac": "A0AAA9S7D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#A0AAA9S7D7-1", "sequence": { "sequence": "RNHCQFQAAAGKRASKASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 266, "header": "tr|A0AAA9S7D7-1|A0AAA9S7D7_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=1 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11430266, "end_pos": 11393829, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116061.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116061.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081914.1" } ] } }, { "isoform_ac": "A0AAA9S9X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#A0AAA9S9X1-1", "sequence": { "sequence": "MLRSTVAVLYASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 260, "header": "tr|A0AAA9S9X1-1|A0AAA9S9X1_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=1 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11430266, "end_pos": 11317632, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114982.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114982.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082101.1" } ] } }, { "isoform_ac": "A0AAA9SHQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#A0AAA9SHQ3-1", "sequence": { "sequence": "MDGPAIITQVTNPKEDEGRAPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 276, "header": "tr|A0AAA9SHQ3-1|A0AAA9SHQ3_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=2 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11430266, "end_pos": 11308937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127497.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127497.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085741.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085741.2" } ] } }, { "isoform_ac": "A0AAA9SVS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#A0AAA9SVS5-1", "sequence": { "sequence": "TRRTSFFYLPASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 260, "header": "tr|A0AAA9SVS5-1|A0AAA9SVS5_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=1 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11430266, "end_pos": 11339361, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128361.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128361.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089422.1" } ] } }, { "isoform_ac": "A0AAA9T0F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#A0AAA9T0F0-1", "sequence": { "sequence": "MDGPAIITQVTNPKEDEGRAPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSR", "length": 265, "header": "tr|A0AAA9T0F0-1|A0AAA9T0F0_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=2 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11430266, "end_pos": 11308937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105664.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105664.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092247.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092247.2" } ] } }, { "isoform_ac": "F1MB22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745/entry#F1MB22-1", "sequence": { "sequence": "MDGPAIITQVTNPKEDEGRAPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVDAPPGSSPGVLPPLVEENGGLQKGDQRQIIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSQEDDVYSMLHRLCSSWIPMELFGNFLCCYRAATKWN", "length": 297, "header": "tr|F1MB22-1|A0AAA9S745_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=CTDSPL PE=4 SV=5 CANONICAL=A0AAA9S745-1" }, "locus": { "chromosome": "22", "start_pos": 11431303, "end_pos": 11308937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017828.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017828.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017828.8", "url": "https://www.ensembl.org/id/ENSBTAP00000017828.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:538425", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538425", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase II CTD heptapeptide repeat phosphatase activity", "id": "GO:0008420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008420", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S745", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] } ] }, { "uniprot_ac": "A0A3Q1MV48", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] } ] }, { "uniprot_ac": "A0A3Q1N5B2", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S454", "gene_name": "LOC112441581", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] } ] }, { "uniprot_ac": "A0AAA9S745", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2KJD7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] }, { "uniprot_ac": "Q3SWW9", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.53", "activity": "O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] } ] }, { "uniprot_ac": "Q3T0E7", "gene_name": "PPP1CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] } ] }, { "uniprot_ac": "Q3ZBF9", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] } ] }, { "uniprot_ac": "Q58DC0", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" }, { "id": "PS50969", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50969" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FCP1 homology", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 378, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.16", "ec_name": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16" }, { "id": "3.1.3.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.16" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S751-1", "uniprot_ac": "A0AAA9S751", "uniprot_id": "A0AAA9S751_BOVIN", "mass": { "chemical_mass": 78555.0, "monoisotopic_mass": 78555.0 }, "refseq": { "ac": "XP_024838080", "name": "WD repeat-containing protein 93 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838080" }, "gene_names": [ { "name": "WDR93", "type": "recommended", "evidence": [ { "id": "A0AAA9S751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751" } ] }, { "name": "WDR93", "type": "synonym", "evidence": [ { "id": "XP_024838080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838080" } ] } ], "protein_names": [ { "name": "WD repeat domain 93", "type": "synonym", "evidence": [ { "id": "A0AAA9S751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 93 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838080" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S751", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751", "locus": { "chromosome": "21", "start_pos": 21158310, "end_pos": 21105997, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055143", "url": "https://www.ensembl.org/id/ENSBTAG00000055143" } ] } } ], "crossref": [ { "id": "A0AAA9S751", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S751", "database": "AlphaFoldDB", "categories": [] }, { "id": "515609", "url": "https://www.ncbi.nlm.nih.gov/gene/515609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12219:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12219:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S751", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S751-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSSVMASPKGSRSQKMKLPIFTRKGTLEVPSPTEKDWSKDDEDDWVFKDPDQEQDSLPQPYRMINKMVNSLFDRSWEMIEARDTSKKAELRRTLPTIYHPLRESKLNTMPNCMDVSQDYVFIGGSKGFSIYNLHNAKQLYVWEKLKVDVISIWATDLGSEILIAPVDEMGIVRLFYFYKDGLYLIKAINELEDASKQTTCIKMEISKGGNFAALLLQGAGDIWLDVYKLPKESWIKEVQYPQLAVNTKKKIRQQLQLNTPDSVTADSLDTDMNISFRGDVKLSLPVQIMKIKPPKPITGTTFKSPLEAFAKIAGCRGLGSGQNHYIKASQWEKREAILRATYKKFLDGEWEPEPISMATFYFLLPSRVIPMPTGVKRSPGLACVLGVHWTDHHNFFFYSLNRTLKDKVDPEGVWPCAAPIVVSQLSPCSSYLVLACEDGVLSLWDLAQGLTLGVVALPEKCFCQSIHFLKYFLVHKGQNVYPEGSVKCHMKCVVLCTDASLHLVTASGIQNSTISLLVERPVKYLDEAICAVAPVQALPGMVLTFSRDGSVFLMDVAKSQIICSFALPRSYSLAAPWNPVFVVSLHHPCFLLRGDHPDEIGSASKAEDIPNSIFYFNFEDYPLLKNFSRNCTIPQASILAHPTFAQALPLEERCEKFFQKSIQNLAKYKVKEEEHWTRLRRYSLLLQKEDLKK", "length": 694, "header": "tr|A0AAA9S751-1|A0AAA9S751_BOVIN Isoform 1 of WD repeat domain 93 OS=Bos taurus OX=9913 GN=WDR93 PE=4 SV=1 CANONICAL=A0AAA9S751-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S751-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751/entry#A0AAA9S751-1", "sequence": { "sequence": "MLSSVMASPKGSRSQKMKLPIFTRKGTLEVPSPTEKDWSKDDEDDWVFKDPDQEQDSLPQPYRMINKMVNSLFDRSWEMIEARDTSKKAELRRTLPTIYHPLRESKLNTMPNCMDVSQDYVFIGGSKGFSIYNLHNAKQLYVWEKLKVDVISIWATDLGSEILIAPVDEMGIVRLFYFYKDGLYLIKAINELEDASKQTTCIKMEISKGGNFAALLLQGAGDIWLDVYKLPKESWIKEVQYPQLAVNTKKKIRQQLQLNTPDSVTADSLDTDMNISFRGDVKLSLPVQIMKIKPPKPITGTTFKSPLEAFAKIAGCRGLGSGQNHYIKASQWEKREAILRATYKKFLDGEWEPEPISMATFYFLLPSRVIPMPTGVKRSPGLACVLGVHWTDHHNFFFYSLNRTLKDKVDPEGVWPCAAPIVVSQLSPCSSYLVLACEDGVLSLWDLAQGLTLGVVALPEKCFCQSIHFLKYFLVHKGQNVYPEGSVKCHMKCVVLCTDASLHLVTASGIQNSTISLLVERPVKYLDEAICAVAPVQALPGMVLTFSRDGSVFLMDVAKSQIICSFALPRSYSLAAPWNPVFVVSLHHPCFLLRGDHPDEIGSASKAEDIPNSIFYFNFEDYPLLKNFSRNCTIPQASILAHPTFAQALPLEERCEKFFQKSIQNLAKYKVKEEEHWTRLRRYSLLLQKEDLKK", "length": 694, "header": "tr|A0AAA9S751-1|A0AAA9S751_BOVIN Isoform 1 of WD repeat domain 93 OS=Bos taurus OX=9913 GN=WDR93 PE=4 SV=1 CANONICAL=A0AAA9S751-1" }, "locus": { "chromosome": "21", "start_pos": 21158035, "end_pos": 21115591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090697.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090697.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081826.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081826.1" } ] } }, { "isoform_ac": "A0AAA9TAC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751/entry#A0AAA9TAC9-1", "sequence": { "sequence": "MLSSVMASPKGSRSQKMKLPIFTRKGTLEVPSPTEKDWSKDDEDDWVFKDPDQEQDSLPQPYRMINKMVNSLFDRSWEMIEARDTSKKAELRRTLPTIYHPLRESIVRLFYFYKDGLYLIKAINELEDASKQTTCIKMEISKGGNFAALLLQGAGDIWLDVYKLPKESWIKEVQYPQLAVNTKKKIRQQLQLNTPDSVTADSLDTDMNISFRGDVKLSLPVQIMKIKPPKPITGTTFKSPLEAFAKIAGCRGLGSGQNHYIKASQWEKREAILRATYKKFLDGEWEPEPISMATFYFLLPSRVIPMPTGVKRSPGLACVLGVHWTDHHNFFFYSLNRTLKDKVDPEGVWPCAAPIVVSQLSPCSSYLVLACEDGVLSLWDLAQGLTLGVVALPEKCFCQSIHFLKYFLVHKGQNVYPEGSVKCHMKCVVLCTDASLHLVTASGIQNSTISLLVERPVKYLDEAICAVAPVQALPGMVLTFSRDGSVFLMDVAKSQIICSFALPRSYSLAAPWNPVFVVSLHHPCFLLRGDHPDEIGSASKAEDIPNSIFYFNFEDYPLLKNFSRNCTIPQASILAHPTFAQALPLEERCEKFFQKSIQNLAKYKVKEEEHWTRLRRYSLLLQKEDLKK", "length": 628, "header": "tr|A0AAA9TAC9-1|A0AAA9TAC9_BOVIN Computationally mapped isoform of WD repeat domain 93 OS=Bos taurus OX=9913 GN=WDR93 PE=4 SV=1 CANONICAL=A0AAA9S751-1" }, "locus": { "chromosome": "21", "start_pos": 21158035, "end_pos": 21115591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100093.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100093.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093830.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515609", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "electron transport chain", "id": "GO:0022900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S751", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S751" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 627, "end_pos": 629, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 274, "end_pos": 276 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 512, "end_pos": 514 }, { "start_pos": 627, "end_pos": 629 }, { "start_pos": 631, "end_pos": 633 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S753-1", "uniprot_ac": "A0AAA9S753", "uniprot_id": "A0AAA9S753_BOVIN", "mass": { "chemical_mass": 24300.0, "monoisotopic_mass": 24300.0 }, "refseq": {}, "gene_names": [ { "name": "RBX1", "type": "recommended", "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase RBX1", "type": "recommended", "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.32", "type": "synonym", "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein transferase RBX1", "type": "synonym", "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 75", "type": "synonym", "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#names_and_taxonomy" } ] }, { "name": "RING-box protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753", "locus": {} } ], "crossref": [ { "id": "A0AAA9S753", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S753", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16485", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16485", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11210", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11210", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12678", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12678", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S753-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ILRISRIGIRKSNGLSGRVSTSEGFRSRPVSGKPSVRSRVQRQQEAGRPPLLLPRKNATRTGGQGVLRGAGKREAEPVLQVAVQAEEGAAAPAESVAGGFPGEGNKSESFRTSPPGSLASAWPRPAPPQPLRPPPPPGQRGWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH", "length": 223, "header": "tr|A0AAA9S753-1|A0AAA9S753_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RBX1 OS=Bos taurus OX=9913 GN=RBX1 PE=3 SV=1 CANONICAL=A0AAA9S753-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S753-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#A0AAA9S753-1", "sequence": { "sequence": "ILRISRIGIRKSNGLSGRVSTSEGFRSRPVSGKPSVRSRVQRQQEAGRPPLLLPRKNATRTGGQGVLRGAGKREAEPVLQVAVQAEEGAAAPAESVAGGFPGEGNKSESFRTSPPGSLASAWPRPAPPQPLRPPPPPGQRGWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH", "length": 223, "header": "tr|A0AAA9S753-1|A0AAA9S753_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RBX1 OS=Bos taurus OX=9913 GN=RBX1 PE=3 SV=1 CANONICAL=A0AAA9S753-1" }, "locus": { "chromosome": "5", "start_pos": 112176066, "end_pos": 112163558, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131357.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131357.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079137.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079137.1" } ] } }, { "isoform_ac": "A0AAA9TDK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753/entry#A0AAA9TDK2-1", "sequence": { "sequence": "MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQNVRFFPFPRICTNSQPLQTVKQKTAFSISCQCSVIRRFHLSY", "length": 146, "header": "tr|A0AAA9TDK2-1|A0AAA9TDK2_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RBX1 OS=Bos taurus OX=9913 GN=RBX1 PE=3 SV=2 CANONICAL=A0AAA9S753-1" }, "locus": { "chromosome": "5", "start_pos": 112174781, "end_pos": 112164182, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094627.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094627.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094847.2", "url": "https://www.ensembl.org/id/ENSBTAP00000094847.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Cul4A-RING E3 ubiquitin ligase complex", "id": "GO:0031464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "cullin-RING ubiquitin ligase complex", "id": "GO:0031461", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031461", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "NEDD8 ligase activity", "id": "GO:0061663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061663", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S753", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S753" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 168, "end_pos": 213, "start_aa": "Cys", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.32", "ec_name": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "2.3.2.32", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.32" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S763-1", "uniprot_ac": "A0AAA9S763", "uniprot_id": "A0AAA9S763_BOVIN", "mass": { "chemical_mass": 71717.0, "monoisotopic_mass": 71717.0 }, "refseq": {}, "gene_names": [ { "name": "STS", "type": "recommended", "evidence": [ { "id": "A0AAA9S763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763" } ] } ], "protein_names": [ { "name": "Steroid sulfatase", "type": "synonym", "evidence": [ { "id": "A0AAA9S763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S763", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763", "locus": { "chromosome": "X", "start_pos": 135464891, "end_pos": 135628089, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020789", "url": "https://www.ensembl.org/id/ENSBTAG00000020789" } ] } } ], "crossref": [ { "id": "A0AAA9S763", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S763", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16159", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16159", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509206", "url": "https://www.ncbi.nlm.nih.gov/gene/509206", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42693", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42693", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42693:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42693:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S763", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S763-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRN7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRN7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZN8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZN8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3U9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3U9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3U9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6M8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6M8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6M8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQKGRDMMTLLLLLLFLCETQSWAASKPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLARGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASQSQVGVFLFSASSGGLPPSEITFAKLLKDQGYSTALIGKWHLGISCHDPGDFCHHPTSHGFDYFHGLPLTNMRDCKLGEGSVFTAAFRLLVLLPMQLIALALLTLVVLKWLGLFRAPPCAFLFLFLLATLLLGLLLGFLHYFRPLNCFLMRNRDITQQPMSYDNLTQRLTADAAHFLRRMHVEMRWRALQSCVLEARGRDADAGQDRRREEKGMTEDEMLRWHHRLHGHEFENAETPFLLVLSFLHMHTALFSSKDFAGKSQHGSYGDAAEEMDWSVGQILDVLDELKLANNTLVYFSSDQGAHVEEVTVKGEVQGGSNGIYKGGKANNWEGGIRVPGIVRWPGVIQAGLEIDEPTSNMDIFPTVAKLAGSPLPQDRVIDGRDLMPLLQMRTQRSEHEFLFHYCNSYLNAVRWHPPNSTSIWKAFFFTPKFSPEGANGCFDTHVCFCYGQYVTYHDPPLLFEISRDPRERNPLTPTSEPRFWEILEAMQEAAARHARTLQDVPNQLSLGNLMWKPWLQLCCSSLGLSCQCDREDQDGRHSP", "length": 638, "header": "tr|A0AAA9S763-1|A0AAA9S763_BOVIN Isoform 1 of Steroid sulfatase OS=Bos taurus OX=9913 GN=STS PE=3 SV=2 CANONICAL=A0AAA9S763-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S763-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763/entry#A0AAA9S763-1", "sequence": { "sequence": "MPQKGRDMMTLLLLLLFLCETQSWAASKPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLARGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASQSQVGVFLFSASSGGLPPSEITFAKLLKDQGYSTALIGKWHLGISCHDPGDFCHHPTSHGFDYFHGLPLTNMRDCKLGEGSVFTAAFRLLVLLPMQLIALALLTLVVLKWLGLFRAPPCAFLFLFLLATLLLGLLLGFLHYFRPLNCFLMRNRDITQQPMSYDNLTQRLTADAAHFLRRMHVEMRWRALQSCVLEARGRDADAGQDRRREEKGMTEDEMLRWHHRLHGHEFENAETPFLLVLSFLHMHTALFSSKDFAGKSQHGSYGDAAEEMDWSVGQILDVLDELKLANNTLVYFSSDQGAHVEEVTVKGEVQGGSNGIYKGGKANNWEGGIRVPGIVRWPGVIQAGLEIDEPTSNMDIFPTVAKLAGSPLPQDRVIDGRDLMPLLQMRTQRSEHEFLFHYCNSYLNAVRWHPPNSTSIWKAFFFTPKFSPEGANGCFDTHVCFCYGQYVTYHDPPLLFEISRDPRERNPLTPTSEPRFWEILEAMQEAAARHARTLQDVPNQLSLGNLMWKPWLQLCCSSLGLSCQCDREDQDGRHSP", "length": 638, "header": "tr|A0AAA9S763-1|A0AAA9S763_BOVIN Isoform 1 of Steroid sulfatase OS=Bos taurus OX=9913 GN=STS PE=3 SV=2 CANONICAL=A0AAA9S763-1" }, "locus": { "chromosome": "Y", "start_pos": 4654301, "end_pos": 4507630, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135512.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135512.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079147.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079147.2" } ] } }, { "isoform_ac": "A0ABI0NRN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763/entry#A0ABI0NRN7-1", "sequence": { "sequence": "MAWDMMTLLLLLLFLCETQSWAASKPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLARGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASQSQVGVFLFSASSGGLPPSEITFAKLLKDQGYSTALIGKWHLGISCHDPGDFCHHPTSHGFDYFHGLPLTNMRDCKLGEGSVFTAAFRLLVLLPMQLIALALLTLVVLKWLGLFRAPPCAFLFLFLLATLLLGLLLGFLHYFRPLNCFLMRNRDITQQPMSYDNLTQRLTADAAHFLRRNAETPFLLVLSFLHMHTALFSSKDFAGKSQHGSYGDAAEEMDWSVGQILDVLDELKLANNTLVYFSSDQGAHVEEVTVKGEVQGGSNGIYKGGKANNWEGGIRVPGIVRWPGVIQAGLEIDEPTSNMDIFPTVAKLAGSPLPQDRVIDGRDLMPLLQMRTQRSEHEFLFHYCNSYLNAVRWHPPNSTSIWKAFFFTPKFSPEGANGCFDTHVCFCYGQYVTYHDPPLLFEISRDPRERNPLTPTSEPRFWEILEAMQEAAARHARTLQDVPNQLSLGNLMWKPWLQLCCSSLGLSCQCDREDQDGRHSP", "length": 582, "header": "tr|A0ABI0NRN7-1|A0ABI0NRN7_BOVIN Computationally mapped isoform of Steroid sulfatase OS=Bos taurus OX=9913 GN=STS PE=3 SV=1 CANONICAL=A0AAA9S763-1" }, "locus": { "chromosome": "Y", "start_pos": 4654301, "end_pos": 4517325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147450.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147450.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105355.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105355.1" } ] } }, { "isoform_ac": "A0ABI0NZN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763/entry#A0ABI0NZN8-1", "sequence": { "sequence": "MLPTRDMMTLLLLLLFLCETQSWAASKPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLARGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASQSQVGVFLFSASSGGLPPSEITFAKLLKDQGYSTALIGKWHLGISCHDPGDFCHHPTSHGFDYFHGLPLTNMRDCKLGEGSVFTAAFRLLVLLPMQLIALALLTLVVLKWLGLFRAPPCAFLFLFLLATLLLGLLLGFLHYFRPLNCFLMRNRDITQQPMSYDNLTQRLTADAAHFLRRNAETPFLLVLSFLHMHTALFSSKDFAGKSQHGSYGDAAEEMDWSVGQILDVLDELKLANNTLVYFSSDQGAHVEEVTVKGEVQGGSNGIYKGGKANNWEGGIRVPGIVRWPGVIQAGLEIDEPTSNMDIFPTVAKLAGSPLPQDRVIDGRDLMPLLQMRTQRSEHEFLFHYCNSYLNAVRWHPPNSTSIWKAFFFTPKFSPEGANGCFDTHVCFCYGQYVTYHDPPLLFEISRDPRERNPLTPTSEPRFWEILEAMQEAAARHARTLQDVPNQLSLGNLMWKPWLQLCCSSLGLSCQCDREDQDGRHSP", "length": 584, "header": "tr|A0ABI0NZN8-1|A0ABI0NZN8_BOVIN Computationally mapped isoform of Steroid sulfatase OS=Bos taurus OX=9913 GN=STS PE=3 SV=1 CANONICAL=A0AAA9S763-1" }, "locus": { "chromosome": "Y", "start_pos": 4654301, "end_pos": 4491498, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153028.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153028.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107186.1" } ] } }, { "isoform_ac": "A0ABI0P3U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763/entry#A0ABI0P3U9-1", "sequence": { "sequence": "MPQKGRDMMTLLLLLLFLCETQSWAASKPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLARGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASQSQVGVFLFSASSGGLPPSEITFAKLLKDQGYSTALIGKWHLGISCHDPGDFCHHPTSHGFDYFHGLPLTNMRDCKLGEGSVFTAAFRLLVLLPMQLIALALLTLVVLKWLGLFRAPPCAFLFLFLLATLLLGLLLGFLHYFRPLNCFLMRNRDITQQPMSYDNLTQRLTADAAHFLRRNAETPFLLVLSFLHMHTALFSSKDFAGKSQHGSYGDAAEEMDWSVGQILDVLDELKLANNTLVYFSSDQGAHVEEVTVKGEVQGGSNGIYKGGKANNWEGGIRVPGIVRWPGVIQAGLEIDEPTSNMDIFPTVAKLAGSPLPQDRVIDGRDLMPLLQMRTQRSEHEFLFHYCNSYLNAVRWHPPNSTSIWKAFFFTPKFSPEGANGCFDTHVCFCYGQYVTYHDPPLLFEISRDPRERNPLTPTSEPRFWEILEAMQEAAARHARTLQDVPNQLSLGNLMWKPWLQLCCSSLGLSCQCDREDQDGRHSP", "length": 585, "header": "tr|A0ABI0P3U9-1|A0ABI0P3U9_BOVIN Computationally mapped isoform of Steroid sulfatase OS=Bos taurus OX=9913 GN=STS PE=3 SV=1 CANONICAL=A0AAA9S763-1" }, "locus": { "chromosome": "Y", "start_pos": 4654301, "end_pos": 4507630, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147637.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147637.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105333.1" } ] } }, { "isoform_ac": "A0ABI0P6M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763/entry#A0ABI0P6M8-1", "sequence": { "sequence": "MPQKGRDMMTLLLLLLFLCETQSWAASKPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLARGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGKWHLGISCHDPGDFCHHPTSHGFDYFHGLPLTNMRDCKLGEGSVFTAAFRLLVLLPMQLIALALLTLVVLKWLGLFRAPPCAFLFLFLLATLLLGLLLGFLHYFRPLNCFLMRNRDITQQPMSYDNLTQRLTADAAHFLRRNAETPFLLVLSFLHMHTALFSSKDFAGKSQHGSYGDAAEEMDWSVGQILDVLDELKLANNTLVYFSSDQGAHVEEVTVKGEVQGGSNGIYKGGKANNWEGGIRVPGIVRWPGVIQAGLEIDEPTSNMDIFPTVAKLAGSPLPQDRVIDGRDLMPLLQMRTQRSEHEFLFHYCNSYLNAVRWHPPNSTSIWKAFFFTPKFSPEGANGCFDTHVCFCYGQYVTYHDPPLLFEISRDPRERNPLTPTSEPRFWEILEAMQEAAARHARTLQDVPNQLSLGNLMWKPWLQLCCSSLGLSCQCDREDQDGRHSP", "length": 544, "header": "tr|A0ABI0P6M8-1|A0ABI0P6M8_BOVIN Computationally mapped isoform of Steroid sulfatase OS=Bos taurus OX=9913 GN=STS PE=3 SV=1 CANONICAL=A0AAA9S763-1" }, "locus": { "chromosome": "Y", "start_pos": 4654301, "end_pos": 4507630, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151819.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151819.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107633.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107633.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 461, "start_aa": "Thr", "end_pos": 461, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr461", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S763", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S763", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S763" }, { "id": "PF00884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfatase N-terminal", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 169, "start_aa": "Pro", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 461 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 514, "end_pos": 516 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7A5-1", "uniprot_ac": "A0AAA9S7A5", "uniprot_id": "A0AAA9S7A5_BOVIN", "mass": { "chemical_mass": 70101.0, "monoisotopic_mass": 70101.0 }, "refseq": { "ac": "XP_015313856", "name": "cationic amino acid transporter 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313856" }, "gene_names": [ { "name": "LOC513941", "type": "recommended", "evidence": [ { "id": "A0AAA9S7A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" } ] }, { "name": "LOC513941", "type": "synonym", "evidence": [ { "id": "XP_015313856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313856" } ] } ], "protein_names": [ { "name": "Cationic amino acid transporter C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S7A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5/entry#names_and_taxonomy" } ] }, { "name": "cationic amino acid transporter 3", "type": "synonym", "evidence": [ { "id": "XP_015313856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313856" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC513941", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7A5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7A5", "database": "AlphaFoldDB", "categories": [] }, { "id": "513941", "url": "https://www.ncbi.nlm.nih.gov/gene/513941", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513941", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513941", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015313856", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313856", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTMLGQYLRQFGQKLVRRKPQFREEPESSETPPLNTLDLVVIGLDNMLGAGIYILIGGVAKYVAGPAIILFLLVAGLTTLLSGLCYVELAAGVEKPGTVYFISYVTMGQLYAFITGWNLLLYLIIAIACIARAWSSIFDSLIGNHISEALEGTFSLQMPYFLASFPDFLALGLVLLLTGLLALRVYESTLIYKVFTGLNILVLSFIILSGFIKGDLHNWKLMEQDYTLAAAGSGDAYSLGLLGSGGFVPFAFDGILQGAATCFYAFVGFAGIVNAGRKASNPQWSMPLAVMISFFICFLVCFGVSAALTLMVPYYLIQLESPLLQAFIYVGWNSAKYVMAVGTLSILLYSLLSIMFIMSQLTYAMAEDGLLFRGLAWIPVHTDAHTIIIRTTYARIIVHTVAPTGTPIMAILVPGTLAAVMVLLFDFTDLVDLMSFQSLLAYSLVTFSVLVLRYQPAQNGNKKEKTEEETETKPEVEGGPLESEPEVGTSNILQSLWFPPSTIPTRKSGQIVYGCASLVVLLLIILSLILYRWSSQVFSGDPVLTTVAVLLLLLITGVTVIIWRQPHNASTLPFRVPALPALFLVSTFMNVYLMIQMTTRTWAQFGIWMAIGFAIYFGYGIQHSLGENSDQQPAASTSQT", "length": 641, "header": "tr|A0AAA9S7A5-1|A0AAA9S7A5_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC513941 PE=3 SV=1 CANONICAL=A0AAA9S7A5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5/entry#A0AAA9S7A5-1", "sequence": { "sequence": "MSTMLGQYLRQFGQKLVRRKPQFREEPESSETPPLNTLDLVVIGLDNMLGAGIYILIGGVAKYVAGPAIILFLLVAGLTTLLSGLCYVELAAGVEKPGTVYFISYVTMGQLYAFITGWNLLLYLIIAIACIARAWSSIFDSLIGNHISEALEGTFSLQMPYFLASFPDFLALGLVLLLTGLLALRVYESTLIYKVFTGLNILVLSFIILSGFIKGDLHNWKLMEQDYTLAAAGSGDAYSLGLLGSGGFVPFAFDGILQGAATCFYAFVGFAGIVNAGRKASNPQWSMPLAVMISFFICFLVCFGVSAALTLMVPYYLIQLESPLLQAFIYVGWNSAKYVMAVGTLSILLYSLLSIMFIMSQLTYAMAEDGLLFRGLAWIPVHTDAHTIIIRTTYARIIVHTVAPTGTPIMAILVPGTLAAVMVLLFDFTDLVDLMSFQSLLAYSLVTFSVLVLRYQPAQNGNKKEKTEEETETKPEVEGGPLESEPEVGTSNILQSLWFPPSTIPTRKSGQIVYGCASLVVLLLIILSLILYRWSSQVFSGDPVLTTVAVLLLLLITGVTVIIWRQPHNASTLPFRVPALPALFLVSTFMNVYLMIQMTTRTWAQFGIWMAIGFAIYFGYGIQHSLGENSDQQPAASTSQT", "length": 641, "header": "tr|A0AAA9S7A5-1|A0AAA9S7A5_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC513941 PE=3 SV=1 CANONICAL=A0AAA9S7A5-1" }, "locus": { "chromosome": "18", "start_pos": 61139161, "end_pos": 61133284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094919.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094919.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081096.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513941", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513941", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7A5" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 575, "end_pos": 625, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 569, "end_pos": 571 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7D9-1", "uniprot_ac": "A0AAA9S7D9", "uniprot_id": "A0AAA9S7D9_BOVIN", "mass": { "chemical_mass": 27888.0, "monoisotopic_mass": 27888.0 }, "refseq": {}, "gene_names": [ { "name": "BCL7A", "type": "recommended", "evidence": [ { "id": "A0AAA9S7D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9" } ] } ], "protein_names": [ { "name": "B-cell CLL/lymphoma 7 protein family member A", "type": "recommended", "evidence": [ { "id": "A0AAA9S7D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9", "locus": { "chromosome": "17", "start_pos": 53301513, "end_pos": 53332694, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032517", "url": "https://www.ensembl.org/id/ENSBTAG00000032517" } ] } } ], "crossref": [ { "id": "A0AAA9S7D9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7D9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032517", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032517", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616240", "url": "https://www.ncbi.nlm.nih.gov/gene/616240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616240", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616240", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12767", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12767", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12767:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12767:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9933937", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933937", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9933939", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933939", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9933946", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933946", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9933947", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933947", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9934037", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9934037", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0N3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0N3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST5", "url": "https://www.uniprot.org/uniprotkb/F1MST5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST5-1", "url": "https://www.uniprot.org/uniprotkb/F1MST5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TGHKASRGPRFSTLSKSTSRPESAPSTLRSREPHRKLALLQPLPHIRGRGRAAAPAPQECVRSTAGRPAGPLSTGDPSAPAASEEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPNSAAPGDGTDTKVDEAQVDGKELPGAEDASDEQNSQSSMENSMNSSEQVERQPSGDAGLAAETSTISQDLEGVPPSKKMKLEASQQNSEEM", "length": 263, "header": "tr|A0AAA9S7D9-1|A0AAA9S7D9_BOVIN Isoform 1 of B-cell CLL/lymphoma 7 protein family member A OS=Bos taurus OX=9913 GN=BCL7A PE=3 SV=1 CANONICAL=A0AAA9S7D9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9/entry#A0AAA9S7D9-1", "sequence": { "sequence": "TGHKASRGPRFSTLSKSTSRPESAPSTLRSREPHRKLALLQPLPHIRGRGRAAAPAPQECVRSTAGRPAGPLSTGDPSAPAASEEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPNSAAPGDGTDTKVDEAQVDGKELPGAEDASDEQNSQSSMENSMNSSEQVERQPSGDAGLAAETSTISQDLEGVPPSKKMKLEASQQNSEEM", "length": 263, "header": "tr|A0AAA9S7D9-1|A0AAA9S7D9_BOVIN Isoform 1 of B-cell CLL/lymphoma 7 protein family member A OS=Bos taurus OX=9913 GN=BCL7A PE=3 SV=1 CANONICAL=A0AAA9S7D9-1" }, "locus": { "chromosome": "17", "start_pos": 53332495, "end_pos": 53304779, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094262.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094262.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081140.1" } ] } }, { "isoform_ac": "A0AAA9T5V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9/entry#A0AAA9T5V5-1", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPNSAAPGDGTDTKVDEAQVDGKELPGAEDASDEQNSQSSMENSMNSSEQVERQPSGDAGLAAETSTISQQNSIWMKDESGSLFPPFCFFWETRGDKQDSRRRITTQASVEIAGSPRQARGADTVEGEHKMTPRIRGCH", "length": 256, "header": "tr|A0AAA9T5V5-1|A0AAA9T5V5_BOVIN Computationally mapped isoform of B-cell CLL/lymphoma 7 protein family member A OS=Bos taurus OX=9913 GN=BCL7A PE=3 SV=1 CANONICAL=A0AAA9S7D9-1" }, "locus": { "chromosome": "17", "start_pos": 53331823, "end_pos": 53302517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125971.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125971.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092117.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092117.1" } ] } }, { "isoform_ac": "A0AAA9TIQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9/entry#A0AAA9TIQ3-1", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPNSAAPGDGTDTKVDEAQVDGKELPGAEGLYSREKEDNNNCKDASDEQNSQSSMENSMNSSEQVERQPSGDAGLAAETSTISQDLEGVPPSKKMKLEASQQNSEEM", "length": 224, "header": "tr|A0AAA9TIQ3-1|A0AAA9TIQ3_BOVIN Computationally mapped isoform of B-cell CLL/lymphoma 7 protein family member A OS=Bos taurus OX=9913 GN=BCL7A PE=3 SV=1 CANONICAL=A0AAA9S7D9-1" }, "locus": { "chromosome": "17", "start_pos": 53331823, "end_pos": 53304779, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098340.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098340.1" } ] } }, { "isoform_ac": "A0AAA9U0N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9/entry#A0AAA9U0N3-1", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPNSAAPGDGTDTKVDEAQVDGKELPGAEDASDEQNSQSSMENSMNSSEQVERQPSGDAGLAAETSTISQVPRSRSQRGSQLGQEPAGVLGDLEGVPPSKKMKLEASQQNSEEM", "length": 231, "header": "tr|A0AAA9U0N3-1|A0AAA9U0N3_BOVIN Computationally mapped isoform of B-cell CLL/lymphoma 7 protein family member A OS=Bos taurus OX=9913 GN=BCL7A PE=3 SV=1 CANONICAL=A0AAA9S7D9-1" }, "locus": { "chromosome": "17", "start_pos": 53331823, "end_pos": 53304779, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131671.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131671.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102646.1" } ] } }, { "isoform_ac": "F1MST5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9/entry#F1MST5-1", "sequence": { "sequence": "MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMHDDNSNQSSIADASPIKQENSSNSSPAPEPNSAAPGDGTDTKVDEAQVDGKELPGAEDASDEQNSQSSMENSMNSSEQVERQPSGDAGLAAETSTISQMVGTLWYSLSRIHEHPVAGLVTGPTVEETHR", "length": 218, "header": "tr|F1MST5-1|A0AAA9S7D9_BOVIN Computationally mapped isoform of B-cell CLL/lymphoma 7 protein family member A OS=Bos taurus OX=9913 GN=BCL7A PE=3 SV=3 CANONICAL=A0AAA9S7D9-1" }, "locus": { "chromosome": "17", "start_pos": 53331823, "end_pos": 53307681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005481.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005481.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005481.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005481.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616240", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616240", "resource": "KEGG Pathway" }, { "id": "R-BTA-9933937", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933937", "resource": "Reactome", "description": "Formation of the canonical BAF (cBAF) complex" }, { "id": "R-BTA-9933939", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933939", "resource": "Reactome", "description": "Formation of the polybromo-BAF (pBAF) complex" }, { "id": "R-BTA-9933946", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933946", "resource": "Reactome", "description": "Formation of the embryonic stem cell BAF (esBAF) complex" }, { "id": "R-BTA-9933947", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933947", "resource": "Reactome", "description": "Formation of the non-canonical BAF (ncBAF) complex" }, { "id": "R-BTA-9934037", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9934037", "resource": "Reactome", "description": "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 216, "end_pos": 218 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7G1-1", "uniprot_ac": "A0AAA9S7G1", "uniprot_id": "A0AAA9S7G1_BOVIN", "mass": { "chemical_mass": 53222.0, "monoisotopic_mass": 53222.0 }, "refseq": { "ac": "XP_024839377", "name": "T-complex protein 11 homolog isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839377" }, "gene_names": [ { "name": "TCP11", "type": "recommended", "evidence": [ { "id": "A0AAA9S7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1" } ] }, { "name": "TCP11", "type": "synonym", "evidence": [ { "id": "XP_024839377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839377" } ] } ], "protein_names": [ { "name": "T-complex 11", "type": "synonym", "evidence": [ { "id": "A0AAA9S7G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1/entry#names_and_taxonomy" } ] }, { "name": "T-complex protein 11 homolog isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024839377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839377" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCP11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1", "locus": { "chromosome": "23", "start_pos": 9078654, "end_pos": 9110972, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016891", "url": "https://www.ensembl.org/id/ENSBTAG00000016891" } ] } } ], "crossref": [ { "id": "A0AAA9S7G1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7G1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016891", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016891", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523297", "url": "https://www.ncbi.nlm.nih.gov/gene/523297", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LLXQRIR", "url": "https://omabrowser.org/oma/group/LLXQRIR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMY7", "url": "https://www.orthodb.org/?gene=F1MMY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12832", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12832", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12832:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12832:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839377", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839377", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T718", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T718", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T718-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T718-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMY7", "url": "https://www.uniprot.org/uniprotkb/F1MMY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMY7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDVEENVPVKDPGDAESRPCLRNTVNDASKLSSEIGMNRDFRMEEKVLPPGSLEGRIRETMHDAFWDHLKERLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRSEIEEALDMDLLTQEAEHGALNVPHLSKYILNMMTLLCAPVRDEAVQKLENISDPVWLLRGIFQVLGLMKMDMVNYTIQSLQPQLQEHSIQYERAKFQDLLNKQPSLLDHTARWLTRAAAQLSAPPPSGPDAADAASSPCSSPGEAASSPEPLSPTMVLSQGFLNLLLWDPEDDEFPETLLTDRARLQELEAQLRQLTILASVLLVSSSFSGSVLFGSPQFVDKLKRVTRALLEEFKSRPEEEAVLTVSEQVAQEIHQSLKNMGLAALSSDNTASLIGQLQDVARKENCVRSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFGPYYTEILKSLLPPAQVLETEVASL", "length": 478, "header": "tr|A0AAA9S7G1-1|A0AAA9S7G1_BOVIN Isoform 1 of T-complex 11 OS=Bos taurus OX=9913 GN=TCP11 PE=3 SV=1 CANONICAL=A0AAA9S7G1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1/entry#A0AAA9S7G1-1", "sequence": { "sequence": "MTDVEENVPVKDPGDAESRPCLRNTVNDASKLSSEIGMNRDFRMEEKVLPPGSLEGRIRETMHDAFWDHLKERLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRSEIEEALDMDLLTQEAEHGALNVPHLSKYILNMMTLLCAPVRDEAVQKLENISDPVWLLRGIFQVLGLMKMDMVNYTIQSLQPQLQEHSIQYERAKFQDLLNKQPSLLDHTARWLTRAAAQLSAPPPSGPDAADAASSPCSSPGEAASSPEPLSPTMVLSQGFLNLLLWDPEDDEFPETLLTDRARLQELEAQLRQLTILASVLLVSSSFSGSVLFGSPQFVDKLKRVTRALLEEFKSRPEEEAVLTVSEQVAQEIHQSLKNMGLAALSSDNTASLIGQLQDVARKENCVRSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFGPYYTEILKSLLPPAQVLETEVASL", "length": 478, "header": "tr|A0AAA9S7G1-1|A0AAA9S7G1_BOVIN Isoform 1 of T-complex 11 OS=Bos taurus OX=9913 GN=TCP11 PE=3 SV=1 CANONICAL=A0AAA9S7G1-1" }, "locus": { "chromosome": "23", "start_pos": 9110378, "end_pos": 9078835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123232.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123232.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081168.1" } ] } }, { "isoform_ac": "A0AAA9SKK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1/entry#A0AAA9SKK7-1", "sequence": { "sequence": "TSSCGPRGRGLRNTVNDASKLSSEIGMNRDFRMEEKVLPPGSLEGRIRETMHDAFWDHLKERLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRSEIEEALDMDLLTQEAEHGALNVPHLSKYILNMMTLLCAPVRDEAVQKLENISDPVWLLRGIFQVLGLMKMDMVNYTIQSLQPQLQEHSIQYERAKFQDLLNKQPSLLDHTARWLTRAAAQLSAPPPSGPDAADAASSPCSSPGEAASSPEPLSPTMVLSQGFLNLLLWDPEDDEFPETLLTDRARLQELEAQLRQLTILASVLLVSSSFSGSVLFGSPQFVDKLKRVTRALLEEFKSRPEEEAVLTVSEQVAQEIHQSLKNMGLAALSSDNTASLIGQLQDVARKENCVRSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFGPYYTEILKSLLPPAQVLETEVASL", "length": 467, "header": "tr|A0AAA9SKK7-1|A0AAA9SKK7_BOVIN Computationally mapped isoform of T-complex 11 OS=Bos taurus OX=9913 GN=TCP11 PE=3 SV=1 CANONICAL=A0AAA9S7G1-1" }, "locus": { "chromosome": "23", "start_pos": 9110716, "end_pos": 9078835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111020.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111020.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084448.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084448.1" } ] } }, { "isoform_ac": "A0AAA9T718-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1/entry#A0AAA9T718-1", "sequence": { "sequence": "MTDVEENVPVKDPGDAESRPCKPESSGPTREDKSSLRDHPSRLRNTVNDASKLSSEIGMNRDFRMEEKVLPPGSLEGRIRETMHDAFWDHLKERLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRSEIEEALDMDLLTQEAEHGALNVPHLSKYILNMMTLLCAPVRDEAVQKLENISDPVWLLRGIFQVLGLMKMDMVNYTIQSLQPQLQEHSIQYERAKFQDLLNKQPSLLDHTARWLTRAAAQLSAPPPSGPDAADAASSPCSSPGGGQQPGAPQPHHGAVPGLPEPPPLGP", "length": 298, "header": "tr|A0AAA9T718-1|A0AAA9T718_BOVIN Computationally mapped isoform of T-complex 11 OS=Bos taurus OX=9913 GN=TCP11 PE=3 SV=1 CANONICAL=A0AAA9S7G1-1" }, "locus": { "chromosome": "23", "start_pos": 9110378, "end_pos": 9081585, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100118.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100118.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092393.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092393.1" } ] } }, { "isoform_ac": "F1MMY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1/entry#F1MMY7-1", "sequence": { "sequence": "MKSWPLGPPGKSQEKGLRNTVNDASKLSSEIGMNRDFRMEEKVLPPGSLEGRIRETMHDAFWDHLKERLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRSEIEEALDMDLLTQEAEHGALNVPHLSKYILNMMTLLCAPVRDEAVQKLENISDPVWLLRGIFQVLGLMKMDMVNYTIQSLQPQLQEHSIQYERAKFQDLLNKQPSLLDHTARWLTRAAAQLSAPPPSGPDAADAASSPCSSPGEAASSPEPLSPTMVLSQGFLNLLLWDPEDDEFPETLLTDRARLQELEAQLRQLTILASVLLVSSSFSGSVLFGSPQFVDKLKRVTRALLEEFKSRPEEEAVLTVSEQVAQEIHQSLKNMGLAALSSDNTASLIGQLQDVARKENCVRSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFGPYYTEILKSLLPPAQVLETEVASL", "length": 473, "header": "tr|F1MMY7-1|A0AAA9S7G1_BOVIN Computationally mapped isoform of T-complex 11 OS=Bos taurus OX=9913 GN=TCP11 PE=3 SV=2 CANONICAL=A0AAA9S7G1-1" }, "locus": { "chromosome": "23", "start_pos": 9105993, "end_pos": 9078835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022467.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022467.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022467.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022467.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "germ cell development", "id": "GO:0007281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 182, "end_pos": 184 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7H3-1", "uniprot_ac": "A0AAA9S7H3", "uniprot_id": "A0AAA9S7H3_BOVIN", "mass": { "chemical_mass": 35260.0, "monoisotopic_mass": 35260.0 }, "refseq": { "ac": "NP_001377572", "name": "olfactory receptor family 5 subfamily H member 29", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377572" }, "gene_names": [ { "name": "OR5H29", "type": "recommended", "evidence": [ { "id": "A0AAA9S7H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3" } ] }, { "name": "OR5H29", "type": "synonym", "evidence": [ { "id": "NP_001377572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377572" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S7H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 5 subfamily H member 29", "type": "synonym", "evidence": [ { "id": "NP_001377572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377572" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377572" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5H29", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3", "locus": { "chromosome": "1", "start_pos": 42519994, "end_pos": 42519065, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057851", "url": "https://www.ensembl.org/id/ENSBTAG00000057851" } ] } } ], "crossref": [ { "id": "A0AAA9S7H3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7H3", "database": "AlphaFoldDB", "categories": [] }, { "id": "100139155", "url": "https://www.ncbi.nlm.nih.gov/gene/100139155", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100139155", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139155", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377572", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERKNATELTEVVVTGLTYQPEWQIPLFVLFLFIYIFTIMGNLGLIAVIWNDPHLHTPMYLFLGSLACVDTWLSSTVVPKMLVNIFTKNKRISLSECIVQFFSFGVSATTECFLLPTMSYDRYVAICNPLLYPAIMTNRLCMRMLISSLTGGLLHALLHTCFLFRLTFCNSNIIHQFYCDIMPLFKISCTDPSINVLVIFIFSGSIQVFTILIILVSYTLVLFTILRKKSAQGIRKAFSTCGAHLLSVSLYYGTLLFMYVRPGSTRADDQDMMDSLFYTVIIPFLNPIIYSLRNKKVINSLTIMLKRNI", "length": 309, "header": "tr|A0AAA9S7H3-1|A0AAA9S7H3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5H29 PE=3 SV=1 CANONICAL=A0AAA9S7H3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3/entry#A0AAA9S7H3-1", "sequence": { "sequence": "MERKNATELTEVVVTGLTYQPEWQIPLFVLFLFIYIFTIMGNLGLIAVIWNDPHLHTPMYLFLGSLACVDTWLSSTVVPKMLVNIFTKNKRISLSECIVQFFSFGVSATTECFLLPTMSYDRYVAICNPLLYPAIMTNRLCMRMLISSLTGGLLHALLHTCFLFRLTFCNSNIIHQFYCDIMPLFKISCTDPSINVLVIFIFSGSIQVFTILIILVSYTLVLFTILRKKSAQGIRKAFSTCGAHLLSVSLYYGTLLFMYVRPGSTRADDQDMMDSLFYTVIIPFLNPIIYSLRNKKVINSLTIMLKRNI", "length": 309, "header": "tr|A0AAA9S7H3-1|A0AAA9S7H3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5H29 PE=3 SV=1 CANONICAL=A0AAA9S7H3-1" }, "locus": { "chromosome": "1", "start_pos": 42519991, "end_pos": 42519065, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097526.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097526.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079248.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079248.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100139155", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139155", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7H3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7I8-1", "uniprot_ac": "A0AAA9S7I8", "uniprot_id": "A0AAA9S7I8_BOVIN", "mass": { "chemical_mass": 34888.0, "monoisotopic_mass": 34888.0 }, "refseq": { "ac": "XP_002694471", "name": "cathepsin O", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694471" }, "gene_names": [ { "name": "CTSO", "type": "recommended", "evidence": [ { "id": "A0AAA9S7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8" } ] }, { "name": "CTSO", "type": "synonym", "evidence": [ { "id": "XP_002694471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694471" } ] } ], "protein_names": [ { "name": "Cathepsin O", "type": "recommended", "evidence": [ { "id": "A0AAA9S7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8/entry#names_and_taxonomy" } ] }, { "name": "3.4.22.42", "type": "synonym", "evidence": [ { "id": "A0AAA9S7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8/entry#names_and_taxonomy" } ] }, { "name": "cathepsin O", "type": "synonym", "evidence": [ { "id": "XP_002694471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694471" } ] } ], "function": [ { "annotation": "Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8#function" }, { "database": "UniProtKB", "id": "ARBA00053492", "url": "https://www.uniprot.org/uniprotkb/ARBA00053492#function" }, { "database": "UniProtKB", "id": "A0AAA9SB00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB00#function" }, { "database": "UniProtKB", "id": "A0AAA9SAJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAJ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTSO", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8", "locus": { "chromosome": "17", "start_pos": 43382606, "end_pos": 43357330, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011063", "url": "https://www.ensembl.org/id/ENSBTAG00000011063" } ] } } ], "crossref": [ { "id": "A0AAA9S7I8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7I8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616804", "url": "https://www.ncbi.nlm.nih.gov/gene/616804", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616804", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616804", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694471", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694471", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELRRLWLLCCCCCFYCWGSCAALTPPFGRHPAAAFRESLNRQRYLNSLFPYENSTAVYGINQFSYLFPEEFKAIYLRSSPSRFPRFPAEEYTSISNLSLPLRFDWRDKHVVTQVRNQKTCGGCWAFSVVGAVESVCAIKGQPLEVLSVQQVIDCSYSNYGCNGGSPLSALYWLNKLQVKLVRDSEYPFQAQNGLCRYFSDSHSGSSIKGYSAYDFSGQEDKMAEALLALGPLIVVVDAMSWQDYLGGIIQHHCSSGEANHAVLVTGFDKTGSIPYWIVRNSWGTSWGIDGYVRVKMGGNVCGIADSVSAVFV", "length": 313, "header": "tr|A0AAA9S7I8-1|A0AAA9S7I8_BOVIN Isoform 1 of Cathepsin O OS=Bos taurus OX=9913 GN=CTSO PE=3 SV=1 CANONICAL=A0AAA9S7I8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8/entry#A0AAA9S7I8-1", "sequence": { "sequence": "MELRRLWLLCCCCCFYCWGSCAALTPPFGRHPAAAFRESLNRQRYLNSLFPYENSTAVYGINQFSYLFPEEFKAIYLRSSPSRFPRFPAEEYTSISNLSLPLRFDWRDKHVVTQVRNQKTCGGCWAFSVVGAVESVCAIKGQPLEVLSVQQVIDCSYSNYGCNGGSPLSALYWLNKLQVKLVRDSEYPFQAQNGLCRYFSDSHSGSSIKGYSAYDFSGQEDKMAEALLALGPLIVVVDAMSWQDYLGGIIQHHCSSGEANHAVLVTGFDKTGSIPYWIVRNSWGTSWGIDGYVRVKMGGNVCGIADSVSAVFV", "length": 313, "header": "tr|A0AAA9S7I8-1|A0AAA9S7I8_BOVIN Isoform 1 of Cathepsin O OS=Bos taurus OX=9913 GN=CTSO PE=3 SV=1 CANONICAL=A0AAA9S7I8-1" }, "locus": { "chromosome": "17", "start_pos": 43381602, "end_pos": 43357529, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108392.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108392.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079893.1" } ] } }, { "isoform_ac": "A0AAA9SAJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8/entry#A0AAA9SAJ0-1", "sequence": { "sequence": "EQGISFLIFTHNLFQRVLKESLNRQRYLNSLFPYENSTAVYGINQFSYLFPEEFKAIYLRSSPSRFPRFPAEEYTSISNLSLPLRFDWRDKHVVTQVRNQKTCGGCWAFSVVGAVESVCAIKGQPLEVLSVQQVIDCSYSNYGCNGGSPLSALYWLNKLQVKLVRDSEYPFQAQNGLCRYFSDSHSGSSIKGYSAYDFSGQEDKMAEALLALGPLIVVVDAMSWQDYLGGIIQHHCSSGEANHAVLVTGFDKTGSIPYWIVRNSWGTSWGIDGYVRVKMGGNVCGIADSVSAVFV", "length": 295, "header": "tr|A0AAA9SAJ0-1|A0AAA9SAJ0_BOVIN Computationally mapped isoform of Cathepsin O OS=Bos taurus OX=9913 GN=CTSO PE=3 SV=2 CANONICAL=A0AAA9S7I8-1" }, "locus": { "chromosome": "17", "start_pos": 43381602, "end_pos": 43361599, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096865.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096865.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079192.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079192.2" } ] } }, { "isoform_ac": "A0AAA9SB00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8/entry#A0AAA9SB00-1", "sequence": { "sequence": "RNKSTAIFLKNIFGDWNHKEARESLNRQRYLNSLFPYENSTAVYGINQFSYLFPEEFKAIYLRSSPSRFPRFPAEEYTSISNLSLPLRFDWRDKHVVTQVRNQKTCGGCWAFSVVGAVESVCAIKGQPLEVLSVQQVIDCSYSNYGCNGGSPLSALYWLNKLQVKLVRDSEYPFQAQNGLCRYFSDSHSGSSIKGYSAYDFSGQEDKMAEALLALGPLIVVVDAMSWQDYLGGIIQHHCSSGEANHAVLVTGFDKTGSIPYWIVRNSWGTSWGIDGYVRVKMGGNVCGIADSVSAVFV", "length": 298, "header": "tr|A0AAA9SB00-1|A0AAA9SB00_BOVIN Computationally mapped isoform of Cathepsin O OS=Bos taurus OX=9913 GN=CTSO PE=3 SV=1 CANONICAL=A0AAA9S7I8-1" }, "locus": { "chromosome": "17", "start_pos": 43381602, "end_pos": 43359249, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122849.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122849.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082534.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082534.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:616804", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616804", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7I8" }, { "id": "SM00645", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00645" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase C1A papain C-terminal", "eco_id": "ECO_0000259", "start_pos": 100, "end_pos": 312, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.22.42", "ec_name": "The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.", "evidence": [] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 54, "end_pos": 56 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7J0-1", "uniprot_ac": "A0AAA9S7J0", "uniprot_id": "A0AAA9S7J0_BOVIN", "mass": { "chemical_mass": 95182.0, "monoisotopic_mass": 95182.0 }, "refseq": {}, "gene_names": [ { "name": "CEP97", "type": "recommended", "evidence": [ { "id": "A0AAA9S7J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ] } ], "protein_names": [ { "name": "Centrosomal protein of 97 kDa", "type": "recommended", "evidence": [ { "id": "A0AAA9S7J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#names_and_taxonomy" } ] }, { "name": "Leucine-rich repeat and IQ domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S7J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.", "evidence": [ { "database": "UniProtKB", "id": "E1BBI2", "url": "https://www.uniprot.org/uniprotkb/E1BBI2#function" }, { "database": "UniProtKB", "id": "ARBA00058656", "url": "https://www.uniprot.org/uniprotkb/ARBA00058656#function" }, { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0#function" }, { "database": "UniProtKB", "id": "A0AAA9SI69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI69#function" }, { "database": "UniProtKB", "id": "A0AAA9T0P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P8#function" }, { "database": "UniProtKB", "id": "A0AAA9U108", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U108#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0", "locus": { "chromosome": "1", "start_pos": 46102566, "end_pos": 46066812, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013464", "url": "https://www.ensembl.org/id/ENSBTAG00000013464" } ] } } ], "crossref": [ { "id": "A0AAA9S7J0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7J0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013464", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013464", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BBI2", "url": "https://www.orthodb.org/?gene=E1BBI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U108", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U108", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U108-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U108-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBI2", "url": "https://www.uniprot.org/uniprotkb/E1BBI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBI2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAACAAAALPPGEVVNWSGQGLQKLSPNLPCEADIHTLILDKNQIIKLENLEKCKRLVQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAMEQINTCTSLQHLDLSDNNIPQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLSLRVLDGYMISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSHNEESSPVESRASLVPEHSSPIQDGQVVPESEPVIQVNSWVGISSHDDQSHAVKNNFPTPVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLSLEDDAAADESVKGPENQDLSNKEEEKALGAANENSVQMTKSAVGTEINEKDGLLPCPEPTVTSAGLKDHTHSLTSFPESVGRNVFHTQPDSEEARSQTASEKVPCRLLTQKSVPLGQDKVALQKLNEAATKLQACWRGFYARNYNPQARDVRYEIRLRRMQEHIVCLTGEIRRLKKERDEERIQKFVQEEAVRFLWNQVRSLQAWQQTVDQHLSSCHIDVPPISSTLVPSKPPLFTQSQQPSSDQNSDWFIAPDEAPQEKSLPEFPDSGFHSSLTEQVHSLQDSLDFEKSSTEGSESSTMGNSIDTVKYGKESDVGDVSEEHGEWGKEGSNNEQDNSLLEQYLTSVQQLDDADERRHFDEGMGDSKLHLPRSPERLDVLSDSASIDVAQGVSPALQYEVSQTPENCELNAEVQGQQSERDSTFQVLHVGIIV", "length": 856, "header": "tr|A0AAA9S7J0-1|A0AAA9S7J0_BOVIN Isoform 1 of Centrosomal protein of 97 kDa OS=Bos taurus OX=9913 GN=CEP97 PE=4 SV=1 CANONICAL=A0AAA9S7J0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#A0AAA9S7J0-1", "sequence": { "sequence": "MAAACAAAALPPGEVVNWSGQGLQKLSPNLPCEADIHTLILDKNQIIKLENLEKCKRLVQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAMEQINTCTSLQHLDLSDNNIPQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLSLRVLDGYMISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSHNEESSPVESRASLVPEHSSPIQDGQVVPESEPVIQVNSWVGISSHDDQSHAVKNNFPTPVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLSLEDDAAADESVKGPENQDLSNKEEEKALGAANENSVQMTKSAVGTEINEKDGLLPCPEPTVTSAGLKDHTHSLTSFPESVGRNVFHTQPDSEEARSQTASEKVPCRLLTQKSVPLGQDKVALQKLNEAATKLQACWRGFYARNYNPQARDVRYEIRLRRMQEHIVCLTGEIRRLKKERDEERIQKFVQEEAVRFLWNQVRSLQAWQQTVDQHLSSCHIDVPPISSTLVPSKPPLFTQSQQPSSDQNSDWFIAPDEAPQEKSLPEFPDSGFHSSLTEQVHSLQDSLDFEKSSTEGSESSTMGNSIDTVKYGKESDVGDVSEEHGEWGKEGSNNEQDNSLLEQYLTSVQQLDDADERRHFDEGMGDSKLHLPRSPERLDVLSDSASIDVAQGVSPALQYEVSQTPENCELNAEVQGQQSERDSTFQVLHVGIIV", "length": 856, "header": "tr|A0AAA9S7J0-1|A0AAA9S7J0_BOVIN Isoform 1 of Centrosomal protein of 97 kDa OS=Bos taurus OX=9913 GN=CEP97 PE=4 SV=1 CANONICAL=A0AAA9S7J0-1" }, "locus": { "chromosome": "1", "start_pos": 46097916, "end_pos": 46077393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090287.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090287.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081202.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081202.1" } ] } }, { "isoform_ac": "A0AAA9SI69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#A0AAA9SI69-1", "sequence": { "sequence": "MSTLSSGYPGSVVNWSGQGLQKLSPNLPCEADIHTLILDKNQIIKLENLEKCKRLVQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAMEQINTCTSLQHLDLSDNNIPQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLSLRVLDGYMISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSHNEESSPVESRASLVPEHSSPIQDGQVVPESEPVIQVNSWVGISSHDDQSHAVKNNFPTPVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLSLEDDAAADESVKGPENQDLSNKEEEKALGAANENSVQMTKSAVGTEINEKDGLLPCPEPTVTSAGLKDHTHSLTSFPESVGRNVFHTQPDSEEARSQTASEKVPCRLLTQKSVPLGQDKVALQKLNEAATKLQACWRGFYARNYNPQARDVRYEIRLRRMQEHIVCLTGEIRRLKKERDEERIQKFVQEEAVRFLWNQVRSLQAWQQTVDQHLSSCHIDVPPISSTLVPSKPPLFTQSQQPSSDQNSDWFIAPDEAPQEKSLPEFPDSGFHSSLTEQVHSLQDSLDFEKSSTEGSESSTMGNSIDTVKYGKESDVGDVSEEHGEWGKEGSNNEQDNSLLEQYLTSVQQLDDADERRHFDEGMGDSKLHLPRSPERLDVLSDSASIDVAQGVSPALQYEVSQTPENCELNAEVQGQQSERDSTFQVLHVGIIV", "length": 853, "header": "tr|A0AAA9SI69-1|A0AAA9SI69_BOVIN Computationally mapped isoform of Centrosomal protein of 97 kDa OS=Bos taurus OX=9913 GN=CEP97 PE=4 SV=1 CANONICAL=A0AAA9S7J0-1" }, "locus": { "chromosome": "1", "start_pos": 46097916, "end_pos": 46077757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102373.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102373.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083597.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083597.1" } ] } }, { "isoform_ac": "A0AAA9T0P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#A0AAA9T0P8-1", "sequence": { "sequence": "MAAACAAAALPPGEGSVVNWSGQGLQKLSPNLPCEADIHTLILDKNQIIKLENLEKCKRLVQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAMEQINTCTSLQHLDLSDNNIPQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLSLRVLDGYMISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSHNEESSPVESRASLVPEHSSPIQDGQVVPESEPVIQVNSWVGISSHDDQSHAVKNNFPTPVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLSLEDDAAADESVKGPENQDLSNKEEEKALGAANENSVQMTKSAVGTEINEKDGLLPCPEPTVTSAGLKDHTHSLTSFPESVGRNVFHTQPDSEEARSQTASEKVPCRLLTQKSVPLGQDKVALQKLNEAATKLQACWRGFYARNYNPQARDVRYEIRLRRMQEHIVCLTGEIRRLKKERDEERIQKFVQEEAVRFLWNQVRSLQAWQQTVDQHLSSCHIDVPPISSTLVPSKPPLFTQSQQPSSDQNSDWFIAPDEAPQEKSLPEFPDSGFHSSLTEQVHSLQDSLDFEKSSTEGSESSTMGNSIDTVKYGKESDVGDVSEEHGEWGKEGSNNEQDNSLLEQYLTSVQQLDDADERRHFDEGMGDSKLHLPRSPERLDVLSDSASIDVAQGVSPALQYEVSQTPENCELNAEVQGQQSERDSTFQLSASFAARSSTKENQLALH", "length": 869, "header": "tr|A0AAA9T0P8-1|A0AAA9T0P8_BOVIN Computationally mapped isoform of Centrosomal protein of 97 kDa OS=Bos taurus OX=9913 GN=CEP97 PE=4 SV=1 CANONICAL=A0AAA9S7J0-1" }, "locus": { "chromosome": "1", "start_pos": 46099854, "end_pos": 46077393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101506.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101506.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091266.1" } ] } }, { "isoform_ac": "A0AAA9U108-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#A0AAA9U108-1", "sequence": { "sequence": "MSTLSSGYPGSVVNWSGQGLQKLSPNLPCEADIHTLILDKNQIIKLENLEKCKRLVQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGYVEGLKELVHLEWLNLAGNNLKAMEQINTCTSLQHLDLSDNNIPQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLSLRVLDGYMISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSHNEESSPVESRASLVPEHSSPIQDGQVVPESEPVIQVNSWVGISSHDDQSHAVKNNFPTPVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLSLEDDAAADESVKGPENQDLSNKEEEKALGAANENSVQMTKSAVGTEINEKDGLLPCPEPTVTSAGLKDHTHSLTSFPESVGRNVFHTQPDSEEARSQTASEKVPCRLLTQKSVPLGQDKVALQKLNEAATKLQACWRGFYARNYNPQARDVRYEIRLRRMQEHIVCLTGEIRRLKKERDEERIQKFVQEEAVRFLWNQVRSLQAWQQTVDQHLSSCHIDVPPISSTLVPSKPPLFTQSQQPSSDQNSDWFIAPDEAPQEKSLPEFPDSGFHSSLTEQVHSLQDSLDFEKSSTEGSESSTMGNSIDTVKYGKESDVGDVSEEHGEWGKEGSNNEQDNSLLEQYLTSVQQLDDADERRHFDEGMGDSKLHLPRSPERLDVLSDSASIDVAQGVSPALQYEVSQTPENCELNAEVQGQQSERDSTFQLCGCKKRTTRDFFLLGMSRRKAI", "length": 868, "header": "tr|A0AAA9U108-1|A0AAA9U108_BOVIN Computationally mapped isoform of Centrosomal protein of 97 kDa OS=Bos taurus OX=9913 GN=CEP97 PE=4 SV=1 CANONICAL=A0AAA9S7J0-1" }, "locus": { "chromosome": "1", "start_pos": 46102349, "end_pos": 46077757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095488.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095488.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102835.1" } ] } }, { "isoform_ac": "E1BBI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0/entry#E1BBI2-1", "sequence": { "sequence": "MAAACAAAALPPGEGSVVNWSGQGLQKLSPNLPCEADIHTLILDKNQIIKLENLEKCKRLVQAMEQINTCTSLQHLDLSDNNIPQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRCLAILSLAENEIRDLNEVSFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLSLRVLDGYMISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSHNEESSPVESRASLVPEHSSPIQDGQVVPESEPVIQVNSWVGISSHDDQSHAVKNNFPTPVHTARYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPVSPTVELRLQGINLSLEDDAAADESVKGPENQDLSNKEEEKALGAANENSVQMTKSAVGTEINEKDGLLPCPEPTVTSAGLKDHTHSLTSFPESVGRNVFHTQPDSEEARSQTASEKVPCRLLTQKSVPLGQDKVALQKLNEAATKLQACWRGFYARNYNPQARDVRYEIRLRRMQEHIVCLTGEIRRLKKERDEERIQKFVQEEAVRFLWNQVRSLQAWQQTVDQHLSSCHIDVPPISSTLVPSKPPLFTQSQQPSSDQNSDWFIAPDEAPQEKSLPEFPDSGFHSSLTEQVHSLQDSLDFEKSSTEGSESSTMGNSIDTVKYGKESDVGDVSEEHGEWGKEGSNNEQDNSLLEQYLTSVQQLDDADERRHFDEGMGDSKLHLPRSPERLDVLSDSASIDVAQGVSPALQYEVSQTPENCELNAEVQGQQSERDSTFQVLHVGIIV", "length": 805, "header": "tr|E1BBI2-1|E1BBI2_BOVIN Computationally mapped isoform of Centrosomal protein of 97 kDa OS=Bos taurus OX=9913 GN=CEP97 PE=4 SV=2 CANONICAL=A0AAA9S7J0-1" }, "locus": { "chromosome": "1", "start_pos": 46097916, "end_pos": 46077393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017907.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017907.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017907.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017907.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 413, "start_aa": "Thr", "end_pos": 413, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr413", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-9013424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "resource": "Reactome", "description": "RHOV GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "pmid": "" }, { "name": "negative regulation of cilium assembly", "id": "GO:1902018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "pmid": "" }, { "name": "regulation of mitotic spindle assembly", "id": "GO:1901673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901673", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7J0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 413 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 }, { "start_pos": 304, "end_pos": 306 }, { "start_pos": 390, "end_pos": 392 }, { "start_pos": 422, "end_pos": 424 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7K4-1", "uniprot_ac": "A0AAA9S7K4", "uniprot_id": "A0AAA9S7K4_BOVIN", "mass": { "chemical_mass": 16111.0, "monoisotopic_mass": 16111.0 }, "refseq": {}, "gene_names": [ { "name": "LOC528470", "type": "recommended", "evidence": [ { "id": "A0AAA9S7K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ] } ], "protein_names": [ { "name": "Globin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S7K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC528470", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7K4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7K4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049600", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049600", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KPSERHC", "url": "https://omabrowser.org/oma/group/KPSERHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11442:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11442:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MDI9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDI9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7K4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VHLTFPQTNELSHCLGFWQALTPSFLMLFSPCRLLVVYPWTQRFFESFGNLPSADAIMGNAKVKAHDKKVLDSFTKGLKHVDHLKGVFALLSELHCKNLHVSPENISLLGNILVITLAQNFGKEFTPEFLAAYQKVVAGVANALT", "length": 145, "header": "tr|A0AAA9S7K4-1|A0AAA9S7K4_BOVIN Isoform 1 of Globin domain-containing protein OS=Bos taurus OX=9913 GN=LOC528470 PE=3 SV=2 CANONICAL=A0AAA9S7K4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4/entry#A0A3Q1MDI9-1", "sequence": { "sequence": "MVHLTLEGKSHCLGFWQALTPSFLMLFSPCRLLVVYPWTQRFFESFGNLPSADAIMGNAKVKAHDKKVLDSFTKGLKHVDHLKGVFALLSELHCKNLHVSPENISLLGNILVITLAQNFGKEFTPEFLAAYQKVVAGVANALT", "length": 143, "header": "tr|A0A3Q1MDI9-1|A0A3Q1MDI9_BOVIN Computationally mapped isoform of Globin domain-containing protein OS=Bos taurus OX=9913 GN=LOC528470 PE=3 SV=2 CANONICAL=A0AAA9S7K4-1" }, "locus": { "chromosome": "15", "start_pos": 48353303, "end_pos": 48351833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082427.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082427.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068484.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068484.2" } ] } }, { "isoform_ac": "A0AAA9S7K4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4/entry#A0AAA9S7K4-1", "sequence": { "sequence": "VHLTFPQTNELSHCLGFWQALTPSFLMLFSPCRLLVVYPWTQRFFESFGNLPSADAIMGNAKVKAHDKKVLDSFTKGLKHVDHLKGVFALLSELHCKNLHVSPENISLLGNILVITLAQNFGKEFTPEFLAAYQKVVAGVANALT", "length": 145, "header": "tr|A0AAA9S7K4-1|A0AAA9S7K4_BOVIN Isoform 1 of Globin domain-containing protein OS=Bos taurus OX=9913 GN=LOC528470 PE=3 SV=2 CANONICAL=A0AAA9S7K4-1" }, "locus": { "chromosome": "15", "start_pos": 48353303, "end_pos": 48351668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126182.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126182.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078141.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078141.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ], "pmid": "" }, { "name": "oxygen carrier activity", "id": "GO:0005344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "hemoglobin complex", "id": "GO:0005833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7K4" }, { "id": "PS01033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Globin", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 145, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7M2-1", "uniprot_ac": "A0AAA9S7M2", "uniprot_id": "A0AAA9S7M2_BOVIN", "mass": { "chemical_mass": 91216.0, "monoisotopic_mass": 91216.0 }, "refseq": { "ac": "NP_001071538", "name": "inactive dipeptidyl peptidase 10 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071538" }, "gene_names": [ { "name": "DPP10", "type": "recommended", "evidence": [ { "id": "A0AAA9S7M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ] }, { "name": "DPP10", "type": "synonym", "evidence": [ { "id": "NP_001071538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071538" } ] } ], "protein_names": [ { "name": "Dipeptidyl peptidase like 10", "type": "synonym", "evidence": [ { "id": "A0AAA9S7M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2/entry#names_and_taxonomy" } ] }, { "name": "dipeptidyl-peptidase 10 (non-functional)", "type": "synonym", "evidence": [ { "id": "NP_001071538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071538" } ] }, { "name": "inactive dipeptidyl peptidase 10 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001071538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071538" } ] }, { "name": "inactive dipeptidyl peptidase 10", "type": "synonym", "evidence": [ { "id": "NP_001071538", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071538" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPP10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2", "locus": { "chromosome": "2", "start_pos": 67756692, "end_pos": 66123174, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005235", "url": "https://www.ensembl.org/id/ENSBTAG00000005235" } ] } } ], "crossref": [ { "id": "A0AAA9S7M2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7M2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005235", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005235", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617222", "url": "https://www.ncbi.nlm.nih.gov/gene/617222", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617222", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617222", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11731", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11731", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11731:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11731:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00930", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00930", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071538", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM30", "url": "https://www.uniprot.org/uniprotkb/F1MM30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM30-1", "url": "https://www.uniprot.org/uniprotkb/F1MM30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAMKQEQQPTPGARASQAQPADQELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNTTTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSRKYEMTSDTWLSKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVVKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLLCKGPGVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIVKSEIKMLHIDDYELPLQLSFPKDFTDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLVDTDNIIIARFDGRGSGFQGLKILQEIHRRLGSVEVKDQIAAVKFLLKQPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVIAPIIDLKLYASAFSERYLGMPSKDESTYQASSVLHNIHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILRFFSDCLKEEIIVLPQEPEEDE", "length": 800, "header": "tr|A0AAA9S7M2-1|A0AAA9S7M2_BOVIN Isoform 1 of Dipeptidyl peptidase like 10 OS=Bos taurus OX=9913 GN=DPP10 PE=4 SV=2 CANONICAL=A0AAA9S7M2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2/entry#A0AAA9S7M2-1", "sequence": { "sequence": "MTAMKQEQQPTPGARASQAQPADQELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNTTTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSRKYEMTSDTWLSKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVVKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLLCKGPGVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIVKSEIKMLHIDDYELPLQLSFPKDFTDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLVDTDNIIIARFDGRGSGFQGLKILQEIHRRLGSVEVKDQIAAVKFLLKQPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVIAPIIDLKLYASAFSERYLGMPSKDESTYQASSVLHNIHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILRFFSDCLKEEIIVLPQEPEEDE", "length": 800, "header": "tr|A0AAA9S7M2-1|A0AAA9S7M2_BOVIN Isoform 1 of Dipeptidyl peptidase like 10 OS=Bos taurus OX=9913 GN=DPP10 PE=4 SV=2 CANONICAL=A0AAA9S7M2-1" }, "locus": { "chromosome": "2", "start_pos": 67756181, "end_pos": 66957189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118854.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118854.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082016.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082016.2" } ] } }, { "isoform_ac": "A0AAA9U0R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2/entry#A0AAA9U0R1-1", "sequence": { "sequence": "MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNTTTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSRKYEMTSDTWLSKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVVKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLLCKGPGVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIVKSEIKMLHIDDYELPLQLSFPKDFTDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLVDTDNIIIARFDGRGSGFQGLKILQEIHRRLGSVEVKDQIAAVKFLLKQPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVIAPIIDLKLYASAFSERYLGMPSKDESTYQASSVLHNIHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILRFFSDCLKEEIIVLPQEPEEDE", "length": 789, "header": "tr|A0AAA9U0R1-1|A0AAA9U0R1_BOVIN Computationally mapped isoform of Dipeptidyl peptidase like 10 OS=Bos taurus OX=9913 GN=DPP10 PE=4 SV=2 CANONICAL=A0AAA9S7M2-1" }, "locus": { "chromosome": "2", "start_pos": 67756181, "end_pos": 66957461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134751.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134751.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103249.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103249.2" } ] } }, { "isoform_ac": "F1MM30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2/entry#F1MM30-1", "sequence": { "sequence": "MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNTTTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSRKYEMTSDTWLSKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVVKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLLCKGPGVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIVKSEIKMLHIDDYELPLQLSFPKDFTDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLVDTDNIIIARFDGRGSGFQGLKILQEIHRRLGSVEVKDQIAAVKFLLKQPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVIAPIIDLKLYASAFSERYLGMPSKDESTYQASSVLHNIHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILRFFSDCLKEEIIVLPQEPEEDE", "length": 796, "header": "tr|F1MM30-1|F1MM30_BOVIN Computationally mapped isoform of Dipeptidyl peptidase like 10 OS=Bos taurus OX=9913 GN=DPP10 PE=4 SV=3 CANONICAL=A0AAA9S7M2-1" }, "locus": { "chromosome": "2", "start_pos": 67756181, "end_pos": 66123174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006894.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006894.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006894.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006894.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617222", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617222", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" }, { "name": "positive regulation of protein localization to plasma membrane", "id": "GO:1903078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" }, { "name": "regulation of potassium ion transmembrane transport", "id": "GO:1901379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901379", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" }, { "name": "potassium channel regulator activity", "id": "GO:0015459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" }, { "id": "PF00930", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00930" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dipeptidylpeptidase IV N-terminal", "eco_id": "ECO_0000259", "start_pos": 137, "end_pos": 503, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S7M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M2" }, { "id": "PF00326", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00326" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S9 prolyl oligopeptidase catalytic", "eco_id": "ECO_0000259", "start_pos": 585, "end_pos": 787, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 123, "end_pos": 125 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 346, "end_pos": 348 }, { "start_pos": 67, "end_pos": 69 }, { "start_pos": 752, "end_pos": 754 }, { "start_pos": 764, "end_pos": 766 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7N9-1", "uniprot_ac": "A0AAA9S7N9", "uniprot_id": "A0AAA9S7N9_BOVIN", "mass": { "chemical_mass": 39305.0, "monoisotopic_mass": 39305.0 }, "refseq": {}, "gene_names": [ { "name": "SH2D6", "type": "recommended", "evidence": [ { "id": "A0AAA9S7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9" } ] } ], "protein_names": [ { "name": "SH2 domain containing 6", "type": "synonym", "evidence": [ { "id": "A0AAA9S7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH2D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9", "locus": { "chromosome": "11", "start_pos": 49557431, "end_pos": 49564772, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064436", "url": "https://www.ensembl.org/id/ENSBTAG00000064436" } ] } } ], "crossref": [ { "id": "A0AAA9S7N9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7N9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14098:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14098:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S7N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKLSWRKARSGPPLPPPRCANSQAWRKDEPCPSPLSVPGTWRHRHSFLEAPEEEEEEEDKYELPPCEALLRHLTPAHLSGTEEDSLYLDHSAPLGPPTSPLPPPQPQPEMVHSLPARPTPAHHFPPKAAPSPLEALKQSWPFGRQELGEPARAVPGPLKEPDEDIYVECEPSPVPAFTQTLSSPVLTAPVPLPRISMGPRPTITPQEAQNGASKATSEAERRTSLSSVAATQNTSGAQEGNLLGQPWYSGNCDRHAAESALLRCQKDGAYTVRPSSGPRGTQPFTLAVLLHGRVFNIPIRRLADGRHYALGREGRNHEELFSSVAAMVQHYMQHPLPLLDRQSGSRQLTCLLFPTKP", "length": 358, "header": "tr|A0AAA9S7N9-1|A0AAA9S7N9_BOVIN Isoform 1 of SH2 domain containing 6 OS=Bos taurus OX=9913 GN=SH2D6 PE=4 SV=1 CANONICAL=A0AAA9S7N9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9/entry#A0AAA9S7N9-1", "sequence": { "sequence": "MEKLSWRKARSGPPLPPPRCANSQAWRKDEPCPSPLSVPGTWRHRHSFLEAPEEEEEEEDKYELPPCEALLRHLTPAHLSGTEEDSLYLDHSAPLGPPTSPLPPPQPQPEMVHSLPARPTPAHHFPPKAAPSPLEALKQSWPFGRQELGEPARAVPGPLKEPDEDIYVECEPSPVPAFTQTLSSPVLTAPVPLPRISMGPRPTITPQEAQNGASKATSEAERRTSLSSVAATQNTSGAQEGNLLGQPWYSGNCDRHAAESALLRCQKDGAYTVRPSSGPRGTQPFTLAVLLHGRVFNIPIRRLADGRHYALGREGRNHEELFSSVAAMVQHYMQHPLPLLDRQSGSRQLTCLLFPTKP", "length": 358, "header": "tr|A0AAA9S7N9-1|A0AAA9S7N9_BOVIN Isoform 1 of SH2 domain containing 6 OS=Bos taurus OX=9913 GN=SH2D6 PE=4 SV=1 CANONICAL=A0AAA9S7N9-1" }, "locus": { "chromosome": "11", "start_pos": 49564732, "end_pos": 49557898, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130222.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130222.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082038.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082038.1" } ] } }, { "isoform_ac": "A0AAA9T5T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9/entry#A0AAA9T5T3-1", "sequence": { "sequence": "MLSPAVLVPAFTQTLSSPVLTAPVPLPRISMGPRPTITPQEAQNGASKATSEGSAPNREAPSLYLNITPQLEVTRGLAERRTSLSSVAATQNTSGAQEGNLLGQPWYSGNCDRHAAESALLRCQKDGAYTVRPSSGPRGTQPFTLAVLLHGRVFNIPIRRLADGRHYALGREGRNHEELFSSVAAMVQHYMQHPLPLLDRQSGSRQLTCLLFPTKP", "length": 216, "header": "tr|A0AAA9T5T3-1|A0AAA9T5T3_BOVIN Computationally mapped isoform of SH2 domain containing 6 OS=Bos taurus OX=9913 GN=SH2D6 PE=4 SV=2 CANONICAL=A0AAA9S7N9-1" }, "locus": { "chromosome": "11", "start_pos": 49560348, "end_pos": 49557898, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133734.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133734.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093202.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093202.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 120, "start_aa": "Thr", "end_pos": 120, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr120", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N9" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 248, "end_pos": 356, "start_aa": "Trp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 120 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7S4-1", "uniprot_ac": "A0AAA9S7S4", "uniprot_id": "A0AAA9S7S4_BOVIN", "mass": { "chemical_mass": 81912.0, "monoisotopic_mass": 81912.0 }, "refseq": {}, "gene_names": [ { "name": "WDR26", "type": "recommended", "evidence": [ { "id": "A0AAA9S7S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 26", "type": "recommended", "evidence": [ { "id": "A0AAA9S7S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4", "locus": { "chromosome": "16", "start_pos": 27556059, "end_pos": 27592345, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011785", "url": "https://www.ensembl.org/id/ENSBTAG00000011785" } ] } } ], "crossref": [ { "id": "A0AAA9S7S4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7S4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22838", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22838", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22838:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22838:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17814", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17814", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S7S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM23", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TASLGEETLASASSSSDSDTGGASPPPRKKPRASAAEGAGEPGASAGRAGLSPPSSSSSSSSSSSSSSSSSSVVVVVGLPPAAAPSAAAAAAVPHRSSGHSLVSGSIMQANGAGGGGGGGGGGGGGGGGGGGGQGQTQELACLSAQNGESSPSSSSSAGDLAHANGLLPSAPSAASNNSNSLNVNNGVPGGAAAAASATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDSNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS", "length": 769, "header": "tr|A0AAA9S7S4-1|A0AAA9S7S4_BOVIN Isoform 1 of WD repeat-containing protein 26 OS=Bos taurus OX=9913 GN=WDR26 PE=4 SV=1 CANONICAL=A0AAA9S7S4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4/entry#A0AAA9S7S4-1", "sequence": { "sequence": "TASLGEETLASASSSSDSDTGGASPPPRKKPRASAAEGAGEPGASAGRAGLSPPSSSSSSSSSSSSSSSSSSVVVVVGLPPAAAPSAAAAAAVPHRSSGHSLVSGSIMQANGAGGGGGGGGGGGGGGGGGGGGQGQTQELACLSAQNGESSPSSSSSAGDLAHANGLLPSAPSAASNNSNSLNVNNGVPGGAAAAASATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDSNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS", "length": 769, "header": "tr|A0AAA9S7S4-1|A0AAA9S7S4_BOVIN Isoform 1 of WD repeat-containing protein 26 OS=Bos taurus OX=9913 GN=WDR26 PE=4 SV=1 CANONICAL=A0AAA9S7S4-1" }, "locus": { "chromosome": "16", "start_pos": 27592146, "end_pos": 27556760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132912.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132912.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079986.1" } ] } }, { "isoform_ac": "A0AAA9T7N1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4/entry#A0AAA9T7N1-1", "sequence": { "sequence": "TASLGEETLASASSSSDSDTGGASPPPRKKPRASAAEGAGEPGASAGRAGLSPPSSSSSSSSSSSSSSSSSSVVVVVGLPPAAAPSAAAAAAVPHRSSGHSLVSGSIMQANGAGGGGGGGGGGGGGGGGGGGGQGQTQELACLSAQNGESSPSSSSSAGDLAHANGLLPSAPSAASNNSNSLNVNNGVPGGAAAAASATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDSNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEEECSSMDS", "length": 707, "header": "tr|A0AAA9T7N1-1|A0AAA9T7N1_BOVIN Computationally mapped isoform of WD repeat-containing protein 26 OS=Bos taurus OX=9913 GN=WDR26 PE=4 SV=1 CANONICAL=A0AAA9S7S4-1" }, "locus": { "chromosome": "16", "start_pos": 27592146, "end_pos": 27556760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130530.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130530.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092601.1" } ] } }, { "isoform_ac": "A0AAF6DM23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4/entry#A0AAF6DM23-1", "sequence": { "sequence": "MQANGAGGGGGGGGGQGQTQELACLSAQNGESSPSSSSSAGDLAHANGLLPSAPSAASNNSNSLNVNNGVPGGAAAAASATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDSNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS", "length": 635, "header": "tr|A0AAF6DM23-1|A0AAF6DM23_BOVIN Computationally mapped isoform of WD repeat-containing protein 26 OS=Bos taurus OX=9913 GN=WDR26 PE=4 SV=1 CANONICAL=A0AAA9S7S4-1" }, "locus": { "chromosome": "16", "start_pos": 27591825, "end_pos": 27556760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034200.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034200.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034100.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034100.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S4" }, { "id": "PS50897", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50897" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTLH", "eco_id": "ECO_0000259", "start_pos": 264, "end_pos": 339, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 249, "end_pos": 251 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7U4-1", "uniprot_ac": "A0AAA9S7U4", "uniprot_id": "A0AAA9S7U4_BOVIN", "mass": { "chemical_mass": 64792.0, "monoisotopic_mass": 64792.0 }, "refseq": {}, "gene_names": [ { "name": "C1RL", "type": "recommended", "evidence": [ { "id": "A0AAA9S7U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ] } ], "protein_names": [ { "name": "Complement C1r subcomponent like", "type": "synonym", "evidence": [ { "id": "A0AAA9S7U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1RL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4", "locus": { "chromosome": "5", "start_pos": 103288050, "end_pos": 103273356, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016204", "url": "https://www.ensembl.org/id/ENSBTAG00000016204" } ] } } ], "crossref": [ { "id": "A0AAA9S7U4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7U4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24255", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24255", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24255:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24255:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RY02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPW1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRSGREKSCWLKAKGYLRRSHPTECETRTRPSQAPLPVPWLGPSPLRAQMSSSRCLVSKLRELSLGKPHSTRCPGNMLIRRQGGLGFAEADRKQPLLGWASPGRPQATGTQPHLPWPTPRWWFLLWGVLQAFPTQGSVVLLAQWLPQKLTSPGYPEPYVKGQESSTDIEAPEGYVVRLLFQDFDLEPSPDCERDSVTLTASGMDLGQFCGQQGSLLGRPPGQKEFVSSGNSLRLTFSAPASEDKTPGFHKGFLALYQAVAVNYTQPINQATGGPKAIPTPGDNPTEIQSCCQEPYYEAKPSGTLTCTAQVPWKQTQKREEAPRCVPVCGRPVVPISQTRESLGASRAELGSFPWQALTSIYGRGGGALLGDRWVLTAAHTIYPKDSILLGRNRSAQVFLGHTDTDQMLELGRHPVRRVVVHPDYHQEEPHDFHGDIALLELERSVPLGPHLLPVCLPDREALYRPGRWGYVSGFGVEMDWLSTKLKYSRLPVAPRAACEAWLRERQRPEAFTDGMFCAGDQTRPQSVCQGDSGGAFVVWDDRTQRWVATGIVSWGIGCGEGYGFYTKVLDYVDWIRGVMGEKD", "length": 585, "header": "tr|A0AAA9S7U4-1|A0AAA9S7U4_BOVIN Isoform 1 of Complement C1r subcomponent like OS=Bos taurus OX=9913 GN=C1RL PE=4 SV=2 CANONICAL=A0AAA9S7U4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4/entry#A0AAA9RY02-1", "sequence": { "sequence": "MFGEAGGRVVIKFNVYKRLAGYRMSRRSGREKSCWLKAKGYLRRSHPTECETRTRPSQAPLPVPWLGPSPLRAQMSSSRCLVSKLRELSLGKPHSTRCPGNMPQATGTQPHLPWPTPRWWFLLWGVLQAFPTQGSVVLLAQWLPQKLTSPGYPEPYVKGQESSTDIEAPEGYVVRLLFQDFDLEPSPDCERDSVTLTASGMDLGQFCGQQGSLLGRPPGQKEFVSSGNSLRLTFSAPASEDKTPGFHKGFLALYQAVAVNYTQPINQATGGPKAIPTPGDNPTEIQSCCQEPYYEAKPSGTLTCTAQVPWKQTQKREEAPRCVPVCGRPVVPISQTRESLGASRAELGSFPWQALTSIYGRGGGALLGDRWVLTAAHTIYPKDSILLGRNRSAQVFLGHTDTDQMLELGRHPVRRVVVHPDYHQEEPHDFHGDIALLELERSVPLGPHLLPVCLPDREALYRPGRWGYVSGFGVEMDWLSTKLKYSRLPVAPRAACEAWLRERQRPEAFTDGMFCAGDQTRPQSVCQGDSGGAFVVWDDRTQRWVATGIVSWGIGCGEGYGFYTKVLDYVDWIRGVMGEKD", "length": 581, "header": "tr|A0AAA9RY02-1|A0AAA9RY02_BOVIN Computationally mapped isoform of Complement C1r subcomponent like OS=Bos taurus OX=9913 GN=C1RL PE=4 SV=1 CANONICAL=A0AAA9S7U4-1" }, "locus": { "chromosome": "5", "start_pos": 103283580, "end_pos": 103273439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123968.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123968.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074691.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074691.2" } ] } }, { "isoform_ac": "A0AAA9S7U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4/entry#A0AAA9S7U4-1", "sequence": { "sequence": "MSRRSGREKSCWLKAKGYLRRSHPTECETRTRPSQAPLPVPWLGPSPLRAQMSSSRCLVSKLRELSLGKPHSTRCPGNMLIRRQGGLGFAEADRKQPLLGWASPGRPQATGTQPHLPWPTPRWWFLLWGVLQAFPTQGSVVLLAQWLPQKLTSPGYPEPYVKGQESSTDIEAPEGYVVRLLFQDFDLEPSPDCERDSVTLTASGMDLGQFCGQQGSLLGRPPGQKEFVSSGNSLRLTFSAPASEDKTPGFHKGFLALYQAVAVNYTQPINQATGGPKAIPTPGDNPTEIQSCCQEPYYEAKPSGTLTCTAQVPWKQTQKREEAPRCVPVCGRPVVPISQTRESLGASRAELGSFPWQALTSIYGRGGGALLGDRWVLTAAHTIYPKDSILLGRNRSAQVFLGHTDTDQMLELGRHPVRRVVVHPDYHQEEPHDFHGDIALLELERSVPLGPHLLPVCLPDREALYRPGRWGYVSGFGVEMDWLSTKLKYSRLPVAPRAACEAWLRERQRPEAFTDGMFCAGDQTRPQSVCQGDSGGAFVVWDDRTQRWVATGIVSWGIGCGEGYGFYTKVLDYVDWIRGVMGEKD", "length": 585, "header": "tr|A0AAA9S7U4-1|A0AAA9S7U4_BOVIN Isoform 1 of Complement C1r subcomponent like OS=Bos taurus OX=9913 GN=C1RL PE=4 SV=2 CANONICAL=A0AAA9S7U4-1" }, "locus": { "chromosome": "5", "start_pos": 103283580, "end_pos": 103273508, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094343.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094343.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082100.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082100.2" } ] } }, { "isoform_ac": "A0AAA9SD75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4/entry#A0AAA9SD75-1", "sequence": { "sequence": "MSSSRCLVSKLRELSLGKPHSTRCPGNMPQATGTQPHLPWPTPRWWFLLWGVLQAFPTQGSVVLLAQWLPQKLTSPGYPEPYVKGQESSTDIEAPEGYVVRLLFQDFDLEPSPDCERDSVTLTASGMDLGQFCGQQGSLLGRPPGQKEFVSSGNSLRLTFSAPASEDKTPGFHKGFLALYQAVAVNYTQPINQATGGPKAIPTPGDNPTEIQSCCQEPYYEAKPSGTLTCTAQVPWKQTQKREEAPRCVPVCGRPVVPISQTRESLGASRAELGSFPWQALTSIYGRGGGALLGDRWVLTAAHTIYPKDSILLGRNRSAQVFLGHTDTDQMLELGRHPVRRVVVHPDYHQEEPHDFHGDIALLELERSVPLGPHLLPVCLPDREALYRPGRWGYVSGFGVEMDWLSTKLKYSRLPVAPRAACEAWLRERQRPEAFTDGMFCAGDQTRPQSVCQGDSGGAFVVWDDRTQRWVATGIVSWGIGCGEGYGFYTKVLDYVDWIRGVMADKGTDHVVGHVMDQPCQQIHSLALIYKPASETLQPGSTWPLQCSCSQTTFSDDLLTASQGAAPGPGKAPGTLNR", "length": 578, "header": "tr|A0AAA9SD75-1|A0AAA9SD75_BOVIN Computationally mapped isoform of Complement C1r subcomponent like OS=Bos taurus OX=9913 GN=C1RL PE=4 SV=1 CANONICAL=A0AAA9S7U4-1" }, "locus": { "chromosome": "5", "start_pos": 103287282, "end_pos": 103273886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115496.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115496.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080275.1" } ] } }, { "isoform_ac": "A0AAA9SPW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4/entry#A0AAA9SPW1-1", "sequence": { "sequence": "MSSSRCLVSKLRELSLGKPHSTRCPGNMPQATGTQPHLPWPTPRWWFLLWGVLQAFPTQGSVVLLAQWLPQKLTSPGYPEPYVKGQESSTDIEAPEGYVVRLLFQDFDLEPSPDCERDSVTLTASGMDLGQFCGQQGSLLGRPPGQKEFVSSGNSLRLTFSAPASEDKTPGFHKGFLALYQAVAVNYTQPINQATGGPKAIPTPGDNPTEIQSCCQEPYYEAKPSVCGRPVVPISQTRESLGASRAELGSFPWQALTSIYGRGGGALLGDRWVLTAAHTIYPKDSILLGRNRSAQVFLGHTDTDQMLELGRHPVRRVVVHPDYHQEEPHDFHGDIALLELERSVPLGPHLLPVCLPDREALYRPGRWGYVSGFGVEMDWLSTKLKYSRLPVAPRAACEAWLRERQRPEAFTDGMFCAGDQTRPQSVCQGDSGGAFVVWDDRTQRWVATGIVSWGIGCGEGYGFYTKVLDYVDWIRGVMGEKD", "length": 482, "header": "tr|A0AAA9SPW1-1|A0AAA9SPW1_BOVIN Computationally mapped isoform of Complement C1r subcomponent like OS=Bos taurus OX=9913 GN=C1RL PE=4 SV=1 CANONICAL=A0AAA9S7U4-1" }, "locus": { "chromosome": "5", "start_pos": 103283580, "end_pos": 103273886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110830.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110830.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088333.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "pmid": "" }, { "name": "complement activation, classical pathway", "id": "GO:0006958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 137, "end_pos": 261, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S7U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U4" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 343, "end_pos": 582, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 264, "end_pos": 266 }, { "start_pos": 394, "end_pos": 396 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7V1-1", "uniprot_ac": "A0AAA9S7V1", "uniprot_id": "A0AAA9S7V1_BOVIN", "mass": { "chemical_mass": 28523.0, "monoisotopic_mass": 28523.0 }, "refseq": {}, "gene_names": [ { "name": "DNAJC12", "type": "recommended", "evidence": [ { "id": "A0AAA9S7V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 12", "type": "recommended", "evidence": [ { "id": "A0AAA9S7V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1/entry#names_and_taxonomy" } ] }, { "name": "J domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S7V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C2#function" }, { "database": "UniProtKB", "id": "ARBA00053379", "url": "https://www.uniprot.org/uniprotkb/ARBA00053379#function" }, { "database": "UniProtKB", "id": "A0AAA9S7V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1", "locus": { "chromosome": "28", "start_pos": 24248426, "end_pos": 24296594, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010932", "url": "https://www.ensembl.org/id/ENSBTAG00000010932" } ] } } ], "crossref": [ { "id": "A0AAA9S7V1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7V1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44500", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44500", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44500:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44500:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S7V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJ56", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJ56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMVLLLVPVYVVSVSAPETSGKKLWYHSKFCKMLMIPAASRPHPPHVAWSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI", "length": 245, "header": "tr|A0AAA9S7V1-1|A0AAA9S7V1_BOVIN Isoform 1 of DnaJ homolog subfamily C member 12 OS=Bos taurus OX=9913 GN=DNAJC12 PE=4 SV=1 CANONICAL=A0AAA9S7V1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1/entry#A0AAA9S7V1-1", "sequence": { "sequence": "MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMVLLLVPVYVVSVSAPETSGKKLWYHSKFCKMLMIPAASRPHPPHVAWSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI", "length": 245, "header": "tr|A0AAA9S7V1-1|A0AAA9S7V1_BOVIN Isoform 1 of DnaJ homolog subfamily C member 12 OS=Bos taurus OX=9913 GN=DNAJC12 PE=4 SV=1 CANONICAL=A0AAA9S7V1-1" }, "locus": { "chromosome": "28", "start_pos": 24283521, "end_pos": 24248849, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113426.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113426.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078219.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078219.1" } ] } }, { "isoform_ac": "A0AAA9T4C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1/entry#A0AAA9T4C2-1", "sequence": { "sequence": "MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMVGFSLMKG", "length": 107, "header": "tr|A0AAA9T4C2-1|A0AAA9T4C2_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 12 OS=Bos taurus OX=9913 GN=DNAJC12 PE=4 SV=1 CANONICAL=A0AAA9S7V1-1" }, "locus": { "chromosome": "28", "start_pos": 24283521, "end_pos": 24265504, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120107.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120107.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091360.1" } ] } }, { "isoform_ac": "A0AAF6ZJ56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1/entry#A0AAF6ZJ56-1", "sequence": { "sequence": "MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKADGVKLECFLSIPSSFSRISLNEISLPRTVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI", "length": 226, "header": "tr|A0AAF6ZJ56-1|A0AAF6ZJ56_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member C12 OS=Bos taurus OX=9913 GN=DNAJC12 PE=4 SV=1 CANONICAL=A0AAA9S7V1-1" }, "locus": { "chromosome": "28", "start_pos": 24283521, "end_pos": 24248849, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052518.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052518.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048829.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048829.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V1" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 79, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7W9-1", "uniprot_ac": "A0AAA9S7W9", "uniprot_id": "A0AAA9S7W9_BOVIN", "mass": { "chemical_mass": 9939.0, "monoisotopic_mass": 9939.0 }, "refseq": { "ac": "XP_024844565", "name": "small integral membrane protein 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844565" }, "gene_names": [ { "name": "LOC112445190", "type": "recommended", "evidence": [ { "id": "A0AAA9S7W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9" } ] }, { "name": "LOC112445190", "type": "synonym", "evidence": [ { "id": "XP_024844565", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844565" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 13", "type": "synonym", "evidence": [ { "id": "A0AAA9S7W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9/entry#names_and_taxonomy" } ] }, { "name": "small integral membrane protein 13", "type": "synonym", "evidence": [ { "id": "XP_024844565", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844565" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112445190", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7W9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7W9", "database": "AlphaFoldDB", "categories": [] }, { "id": "112445190", "url": "https://www.ncbi.nlm.nih.gov/gene/112445190", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140337", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140337", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR36877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36877:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36877:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844565", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844565", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWHNVGLTLLVFVATLLIVLLLMVCGWYFVWHLFLSKFKFLRELVGDTGSQEGDREPSGSETEEDASPSPHRIRSARQRRAPTDEGH", "length": 87, "header": "tr|A0AAA9S7W9-1|A0AAA9S7W9_BOVIN Isoform 1 of Small integral membrane protein 13 OS=Bos taurus OX=9913 GN=LOC112445190 PE=4 SV=2 CANONICAL=A0AAA9S7W9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W9/entry#A0AAA9S7W9-1", "sequence": { "sequence": "MWHNVGLTLLVFVATLLIVLLLMVCGWYFVWHLFLSKFKFLRELVGDTGSQEGDREPSGSETEEDASPSPHRIRSARQRRAPTDEGH", "length": 87, "header": "tr|A0AAA9S7W9-1|A0AAA9S7W9_BOVIN Isoform 1 of Small integral membrane protein 13 OS=Bos taurus OX=9913 GN=LOC112445190 PE=4 SV=2 CANONICAL=A0AAA9S7W9-1" }, "locus": { "chromosome": "23", "start_pos": 45184714, "end_pos": 45167688, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129867.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129867.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081335.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081335.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140337", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7Y3-1", "uniprot_ac": "A0AAA9S7Y3", "uniprot_id": "A0AAA9S7Y3_BOVIN", "mass": { "chemical_mass": 34841.0, "monoisotopic_mass": 34841.0 }, "refseq": { "ac": "NP_001377066", "name": "olfactory receptor family 8 subfamily B member 1AI", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377066" }, "gene_names": [ { "name": "OR8B1AI", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3" } ] }, { "name": "OR8B1AI", "type": "synonym", "evidence": [ { "id": "NP_001377066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377066" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 8 subfamily B member 1AI", "type": "synonym", "evidence": [ { "id": "A0AAA9S7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 8 subfamily B member 1AI", "type": "synonym", "evidence": [ { "id": "NP_001377066", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377066" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377066" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8B1AI", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3", "locus": { "chromosome": "29", "start_pos": 27158521, "end_pos": 27159450, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061347", "url": "https://www.ensembl.org/id/ENSBTAG00000061347" } ] } } ], "crossref": [ { "id": "A0AAA9S7Y3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7Y3", "database": "AlphaFoldDB", "categories": [] }, { "id": "531816", "url": "https://www.ncbi.nlm.nih.gov/gene/531816", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531816", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531816", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377066", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGNDSFTTQFILVGLTDQSVLQLPLFFLFLVMYMVTVMGNLSLIILIGLSSHLHTPMYFFLFNLSFIDLCYSTVFTLKMLINIISKKKIISYMGCMTQLYFFTFFGISECYVPTSMAYDRYVAICNPLLYKIAMSPKVCSSFMLGSYLMAFLDAMILIGGMLRLNFCDANTINHYLCDTYPLLQLSCTSTYILELEVIIVSGINIILPSLTIFVSDGLILSNILHISSTEGRSKAFRTCSSHIIAVSLFFGSSAFVYLKPSSMPMNKGKVLSVFYTNVVPMMNPLIYSLRNKDVKLALRKVLRMVKF", "length": 309, "header": "tr|A0AAA9S7Y3-1|A0AAA9S7Y3_BOVIN Isoform 1 of Olfactory receptor family 8 subfamily B member 1AI OS=Bos taurus OX=9913 GN=OR8B1AI PE=3 SV=1 CANONICAL=A0AAA9S7Y3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3/entry#A0AAA9S7Y3-1", "sequence": { "sequence": "MAPGNDSFTTQFILVGLTDQSVLQLPLFFLFLVMYMVTVMGNLSLIILIGLSSHLHTPMYFFLFNLSFIDLCYSTVFTLKMLINIISKKKIISYMGCMTQLYFFTFFGISECYVPTSMAYDRYVAICNPLLYKIAMSPKVCSSFMLGSYLMAFLDAMILIGGMLRLNFCDANTINHYLCDTYPLLQLSCTSTYILELEVIIVSGINIILPSLTIFVSDGLILSNILHISSTEGRSKAFRTCSSHIIAVSLFFGSSAFVYLKPSSMPMNKGKVLSVFYTNVVPMMNPLIYSLRNKDVKLALRKVLRMVKF", "length": 309, "header": "tr|A0AAA9S7Y3-1|A0AAA9S7Y3_BOVIN Isoform 1 of Olfactory receptor family 8 subfamily B member 1AI OS=Bos taurus OX=9913 GN=OR8B1AI PE=3 SV=1 CANONICAL=A0AAA9S7Y3-1" }, "locus": { "chromosome": "29", "start_pos": 27159450, "end_pos": 27158524, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080046.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531816", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531816", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7Y6-1", "uniprot_ac": "A0AAA9S7Y6", "uniprot_id": "A0AAA9S7Y6_BOVIN", "mass": { "chemical_mass": 6485.0, "monoisotopic_mass": 6485.0 }, "refseq": {}, "gene_names": [ { "name": "MTLN", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ] } ], "protein_names": [ { "name": "Mitoregulin", "type": "synonym", "evidence": [ { "id": "A0AAA9S7Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTLN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7Y6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7Y6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR038778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37154:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37154:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADVSERTLQLSVLVAFASGVLVGWQANRLRRRYLDWRKKRLQDKLAATQKKLDLA", "length": 56, "header": "tr|A0AAA9S7Y6-1|A0AAA9S7Y6_BOVIN Isoform 1 of Mitoregulin OS=Bos taurus OX=9913 GN=MTLN PE=4 SV=1 CANONICAL=A0AAA9S7Y6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6/entry#A0AAA9S7Y6-1", "sequence": { "sequence": "MADVSERTLQLSVLVAFASGVLVGWQANRLRRRYLDWRKKRLQDKLAATQKKLDLA", "length": 56, "header": "tr|A0AAA9S7Y6-1|A0AAA9S7Y6_BOVIN Isoform 1 of Mitoregulin OS=Bos taurus OX=9913 GN=MTLN PE=4 SV=1 CANONICAL=A0AAA9S7Y6-1" }, "locus": { "chromosome": "11", "start_pos": 1692562, "end_pos": 1692395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118930.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118930.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102167.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102167.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of sequestering of calcium ion", "id": "GO:0051284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "positive regulation of fatty acid beta-oxidation", "id": "GO:0032000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "positive regulation of protein-containing complex assembly", "id": "GO:0031334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "triglyceride homeostasis", "id": "GO:0070328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070328", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial membrane potential", "id": "GO:0010918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010918", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "striated muscle cell differentiation", "id": "GO:0051146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" }, { "name": "cellular respiration", "id": "GO:0045333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Y6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Y6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7Z0-1", "uniprot_ac": "A0AAA9S7Z0", "uniprot_id": "A0AAA9S7Z0_BOVIN", "mass": { "chemical_mass": 4901.0, "monoisotopic_mass": 4901.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "TRAF2 and NCK interacting kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z0", "locus": {} } ], "crossref": [ { "id": "A0AAA9S7Z0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7Z0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR051700", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051700", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47096", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47096", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47096:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47096:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9S7Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKQMNK", "length": 45, "header": "tr|A0AAA9S7Z0-1|A0AAA9S7Z0_BOVIN Isoform 1 of TRAF2 and NCK interacting kinase OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S7Z0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z0/entry#A0AAA9S7Z0-1", "sequence": { "sequence": "MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKQMNK", "length": 45, "header": "tr|A0AAA9S7Z0-1|A0AAA9S7Z0_BOVIN Isoform 1 of TRAF2 and NCK interacting kinase OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S7Z0-1" }, "locus": { "chromosome": "1", "start_pos": 96127541, "end_pos": 96022258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082154.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082154.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7Z5-1", "uniprot_ac": "A0AAA9S7Z5", "uniprot_id": "A0AAA9S7Z5_BOVIN", "mass": { "chemical_mass": 83540.0, "monoisotopic_mass": 83540.0 }, "refseq": { "ac": "XP_002689661", "name": "transcription factor RFX3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689661" }, "gene_names": [ { "name": "RFX3", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ] }, { "name": "RFX3", "type": "synonym", "evidence": [ { "id": "XP_002689661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689661" } ] } ], "protein_names": [ { "name": "Transcription factor RFX3", "type": "recommended", "evidence": [ { "id": "A0AAA9S7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#names_and_taxonomy" } ] }, { "name": "Regulatory factor X 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#names_and_taxonomy" } ] }, { "name": "transcription factor RFX3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689661" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RFX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5", "locus": { "chromosome": "8", "start_pos": 41294949, "end_pos": 40969230, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000819", "url": "https://www.ensembl.org/id/ENSBTAG00000000819" } ] } } ], "crossref": [ { "id": "A0AAA9S7Z5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7Z5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000819", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000819", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538070", "url": "https://www.ncbi.nlm.nih.gov/gene/538070", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057321", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057321", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538070", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538070", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCT7", "url": "https://www.orthodb.org/?gene=A0A3Q1MCT7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MW17", "url": "https://www.orthodb.org/?gene=F1MW17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04589", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04589", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25340", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25340", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689661", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCT7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Z5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T878", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T878", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T878-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T878-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW17", "url": "https://www.uniprot.org/uniprotkb/F1MW17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW17-1", "url": "https://www.uniprot.org/uniprotkb/F1MW17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLNDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELNQAFPVGCMQPVLESGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV", "length": 749, "header": "tr|A0AAA9S7Z5-1|A0AAA9S7Z5_BOVIN Isoform 1 of Transcription factor RFX3 OS=Bos taurus OX=9913 GN=RFX3 PE=4 SV=1 CANONICAL=A0AAA9S7Z5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#A0A3Q1MCT7-1", "sequence": { "sequence": "MIIFHVHCVGERRTERQRKRNCGFFTTEPPGEPHLRETIMQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLNDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELNQAFPVGCMQPVLESGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV", "length": 788, "header": "tr|A0A3Q1MCT7-1|A0A3Q1MCT7_BOVIN Computationally mapped isoform of Transcription factor RFX3 OS=Bos taurus OX=9913 GN=RFX3 PE=4 SV=2 CANONICAL=A0AAA9S7Z5-1" }, "locus": { "chromosome": "8", "start_pos": 41293945, "end_pos": 41077689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081215.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081215.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068190.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068190.2" } ] } }, { "isoform_ac": "A0AAA9S7Z5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#A0AAA9S7Z5-1", "sequence": { "sequence": "MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLNDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELNQAFPVGCMQPVLESGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV", "length": 749, "header": "tr|A0AAA9S7Z5-1|A0AAA9S7Z5_BOVIN Isoform 1 of Transcription factor RFX3 OS=Bos taurus OX=9913 GN=RFX3 PE=4 SV=1 CANONICAL=A0AAA9S7Z5-1" }, "locus": { "chromosome": "8", "start_pos": 41293945, "end_pos": 41107393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104918.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104918.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079438.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079438.1" } ] } }, { "isoform_ac": "A0AAA9SAU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#A0AAA9SAU4-1", "sequence": { "sequence": "MIYCFFEEKEHNSMENGATEEHSETIMQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLNDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELNQAFPVGCMQPVLESGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV", "length": 775, "header": "tr|A0AAA9SAU4-1|A0AAA9SAU4_BOVIN Computationally mapped isoform of Transcription factor RFX3 OS=Bos taurus OX=9913 GN=RFX3 PE=4 SV=1 CANONICAL=A0AAA9S7Z5-1" }, "locus": { "chromosome": "8", "start_pos": 41293945, "end_pos": 41036068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088658.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088658.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079282.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079282.1" } ] } }, { "isoform_ac": "A0AAA9T878-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#A0AAA9T878-1", "sequence": { "sequence": "MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLNDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELNQAFPVGCMQPVLESGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV", "length": 724, "header": "tr|A0AAA9T878-1|A0AAA9T878_BOVIN Computationally mapped isoform of Transcription factor RFX3 OS=Bos taurus OX=9913 GN=RFX3 PE=4 SV=1 CANONICAL=A0AAA9S7Z5-1" }, "locus": { "chromosome": "8", "start_pos": 41293945, "end_pos": 41107393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113312.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113312.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094162.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094162.1" } ] } }, { "isoform_ac": "F1MW17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5/entry#F1MW17-1", "sequence": { "sequence": "MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLNDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEHARPPCPSPTPGVHSDPRPSSQ", "length": 678, "header": "tr|F1MW17-1|F1MW17_BOVIN Computationally mapped isoform of Transcription factor RFX3 OS=Bos taurus OX=9913 GN=RFX3 PE=4 SV=4 CANONICAL=A0AAA9S7Z5-1" }, "locus": { "chromosome": "8", "start_pos": 41270726, "end_pos": 41107393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001085.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001085.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001085.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001085.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 390, "start_aa": "Thr", "end_pos": 390, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr390", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538070", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538070", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "type B pancreatic cell maturation", "id": "GO:0072560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072560", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "regulation of insulin secretion", "id": "GO:0050796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "positive regulation of type B pancreatic cell development", "id": "GO:2000078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "cilium-dependent cell motility", "id": "GO:0060285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" }, { "name": "epithelial cilium movement involved in determination of left/right asymmetry", "id": "GO:0060287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7Z5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Z5" }, { "id": "PS51526", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51526" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RFX-type winged-helix", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 258, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 390 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 402, "end_pos": 404 }, { "start_pos": 515, "end_pos": 517 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S806-1", "uniprot_ac": "A0AAA9S806", "uniprot_id": "A0AAA9S806_BOVIN", "mass": { "chemical_mass": 47638.0, "monoisotopic_mass": 47638.0 }, "refseq": {}, "gene_names": [ { "name": "TPRA1", "type": "recommended", "evidence": [ { "id": "A0AAA9S806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806" } ] } ], "protein_names": [ { "name": "Integral membrane protein GPR175", "type": "recommended", "evidence": [ { "id": "A0AAA9S806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPRA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806", "locus": { "chromosome": "22", "start_pos": 59930157, "end_pos": 59921386, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022575", "url": "https://www.ensembl.org/id/ENSBTAG00000022575" } ] } } ], "crossref": [ { "id": "A0AAA9S806", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S806", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022575", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022575", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR018781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0C4", "url": "https://www.orthodb.org/?gene=A0A3Q1M0C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15876:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15876:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M0C4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0C4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S806-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTWDMGASSPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFFIFLLWKLPFARAKIRVTSSPIFITFYILVFVVALVGIARAVVSMTVSTSDAATVADKILWEITRFFLLAIELSVVILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVVLPRTPLKERISLPSAWTPPPSSTSASLRPSSTWPSCAASSARSPRFSSPTNAKWTRPRSRTCTCPSPTPWPGGRARRRPGRPARSSTRPGWPTWTTWPPCPATAAASTAWTVSAGGPSTPDAAAPGAGPRGTGCGGRGAERPSGTEEGPCPLSVPTSVQPRPLPLPAPPASLGDVALTVCPRAGWPPPPCSLGPRTGLASSPPTPAPEPTPTGGPKCVYFPDLFSNKKDQGGRWWCGSVEG", "length": 445, "header": "tr|A0AAA9S806-1|A0AAA9S806_BOVIN Isoform 1 of Integral membrane protein GPR175 OS=Bos taurus OX=9913 GN=TPRA1 PE=3 SV=1 CANONICAL=A0AAA9S806-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806/entry#A0A3Q1M0C4-1", "sequence": { "sequence": "MVSPTAQTRETQKLREAKAQRGLAAGRMDTWDMGASSPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFFIFLLWKLPFARAKIRVTSSPIFITFYILVFVVALVGIARAVVSMTVSTSDAATVADKILWEITRFFLLAIELSVVILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVVLPRTPLKERISLPSRRSFYVYAGILALLNLVQGLGSALLCADIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDETEEPDMHLPQPYAVARREGPEAAGAASTQFDSAGVAYLDDVASLPCHSGSINSLDSERWRAINA", "length": 385, "header": "tr|A0A3Q1M0C4-1|A0A3Q1M0C4_BOVIN Computationally mapped isoform of Integral membrane protein GPR175 OS=Bos taurus OX=9913 GN=TPRA1 PE=3 SV=2 CANONICAL=A0AAA9S806-1" }, "locus": { "chromosome": "22", "start_pos": 59929427, "end_pos": 59922408, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085728.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085728.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063085.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063085.2" } ] } }, { "isoform_ac": "A0AAA9S806-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806/entry#A0AAA9S806-1", "sequence": { "sequence": "MDTWDMGASSPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFFIFLLWKLPFARAKIRVTSSPIFITFYILVFVVALVGIARAVVSMTVSTSDAATVADKILWEITRFFLLAIELSVVILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVVLPRTPLKERISLPSAWTPPPSSTSASLRPSSTWPSCAASSARSPRFSSPTNAKWTRPRSRTCTCPSPTPWPGGRARRRPGRPARSSTRPGWPTWTTWPPCPATAAASTAWTVSAGGPSTPDAAAPGAGPRGTGCGGRGAERPSGTEEGPCPLSVPTSVQPRPLPLPAPPASLGDVALTVCPRAGWPPPPCSLGPRTGLASSPPTPAPEPTPTGGPKCVYFPDLFSNKKDQGGRWWCGSVEG", "length": 445, "header": "tr|A0AAA9S806-1|A0AAA9S806_BOVIN Isoform 1 of Integral membrane protein GPR175 OS=Bos taurus OX=9913 GN=TPRA1 PE=3 SV=1 CANONICAL=A0AAA9S806-1" }, "locus": { "chromosome": "22", "start_pos": 59929791, "end_pos": 59925853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106861.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106861.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079454.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079454.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 272, "start_aa": "Thr", "end_pos": 272, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr272", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 408, "start_aa": "Thr", "end_pos": 408, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr408", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 414, "start_aa": "Thr", "end_pos": 414, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr414", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S806" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 272, 408, 414 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S810-1", "uniprot_ac": "A0AAA9S810", "uniprot_id": "A0AAA9S810_BOVIN", "mass": { "chemical_mass": 22296.0, "monoisotopic_mass": 22296.0 }, "refseq": { "ac": "XP_002689587", "name": "interferon beta-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689587" }, "gene_names": [ { "name": "LOC525550", "type": "recommended", "evidence": [ { "id": "A0AAA9S810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ] }, { "name": "LOC525550", "type": "synonym", "evidence": [ { "id": "XP_002689587", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689587" } ] } ], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810/entry#names_and_taxonomy" } ] }, { "name": "interferon beta-2", "type": "synonym", "evidence": [ { "id": "XP_002689587", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689587" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC525550", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810", "locus": {} } ], "crossref": [ { "id": "cd00095", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00095", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525550", "url": "https://www.ncbi.nlm.nih.gov/gene/525550", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525550", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525550", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DQANSTW", "url": "https://omabrowser.org/oma/group/DQANSTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11691", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11691", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11691:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11691:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00143", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00143", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689587", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689587", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S810-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHRCLLQMVLLLCFSTTALSRSYSLLRFQQRRSLAVCQKLLWQLPSTPQHCLEARMDFQMPEEMKQAQQFRKEDAILVIYEMLQQIFGILTRDFSSTGWSETIIEDLLEELYGQMNRLQPIQKEIMQKQNSTMGDTTVLHLRKYYFNLVQYLKSKEYNRCAWTVVRVQILRNFSFLTRLTDYLRD", "length": 186, "header": "tr|A0AAA9S810-1|A0AAA9S810_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC525550 PE=3 SV=1 CANONICAL=A0AAA9S810-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S810-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810/entry#A0AAA9S810-1", "sequence": { "sequence": "MTHRCLLQMVLLLCFSTTALSRSYSLLRFQQRRSLAVCQKLLWQLPSTPQHCLEARMDFQMPEEMKQAQQFRKEDAILVIYEMLQQIFGILTRDFSSTGWSETIIEDLLEELYGQMNRLQPIQKEIMQKQNSTMGDTTVLHLRKYYFNLVQYLKSKEYNRCAWTVVRVQILRNFSFLTRLTDYLRD", "length": 186, "header": "tr|A0AAA9S810-1|A0AAA9S810_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC525550 PE=3 SV=1 CANONICAL=A0AAA9S810-1" }, "locus": { "chromosome": "8", "start_pos": 23348279, "end_pos": 23347934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102691.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102691.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081374.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081374.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525550", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525550", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cellular response to dsRNA", "id": "GO:0071359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "negative regulation of immune system process", "id": "GO:0002683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002683", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "leukocyte activation", "id": "GO:0045321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "negative regulation of multicellular organismal process", "id": "GO:0051241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051241", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "positive regulation of biosynthetic process", "id": "GO:0009891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" }, { "name": "cytokine receptor binding", "id": "GO:0005126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005126", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S810", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S810" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 173, "end_pos": 175 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S815-1", "uniprot_ac": "A0AAA9S815", "uniprot_id": "A0AAA9S815_BOVIN", "mass": { "chemical_mass": 28688.0, "monoisotopic_mass": 28688.0 }, "refseq": {}, "gene_names": [ { "name": "DIO1", "type": "recommended", "evidence": [ { "id": "A0AAA9S815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ] } ], "protein_names": [ { "name": "Iodothyronine deiodinase", "type": "recommended", "evidence": [ { "id": "A0AAA9S815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815#function" }, { "database": "UniProtKB", "id": "RU000676", "url": "https://www.uniprot.org/uniprotkb/RU000676#function" }, { "database": "UniProtKB", "id": "A0ABI0NZ86", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ86#function" }, { "database": "UniProtKB", "id": "A0ABI0P2T8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2T8#function" }, { "database": "UniProtKB", "id": "A0ABI0P2V0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2V0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815", "locus": { "chromosome": "3", "start_pos": 92310353, "end_pos": 92330716, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064751", "url": "https://www.ensembl.org/id/ENSBTAG00000064751" } ] } } ], "crossref": [ { "id": "A0AAA9S815", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S815", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11781", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11781", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11781:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11781:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00837", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00837", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "18897", "url": "https://www.rhea-db.org/rhea/18897", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "82571", "url": "https://www.rhea-db.org/rhea/82571", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "82575", "url": "https://www.rhea-db.org/rhea/82575", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "82895", "url": "https://www.rhea-db.org/rhea/82895", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "82899", "url": "https://www.rhea-db.org/rhea/82899", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83751", "url": "https://www.rhea-db.org/rhea/83751", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83783", "url": "https://www.rhea-db.org/rhea/83783", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83795", "url": "https://www.rhea-db.org/rhea/83795", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83803", "url": "https://www.rhea-db.org/rhea/83803", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83811", "url": "https://www.rhea-db.org/rhea/83811", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83823", "url": "https://www.rhea-db.org/rhea/83823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83827", "url": "https://www.rhea-db.org/rhea/83827", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83831", "url": "https://www.rhea-db.org/rhea/83831", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83835", "url": "https://www.rhea-db.org/rhea/83835", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S815-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZ86", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZ86-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2T8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2T8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2T8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2T8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2V0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2V0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2V0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQGNRPLVLNFGSCTPSFIFKFDQFKRLIEDFGSVADFLIIYIEEAHASDGWAFKNNVDIKNHRNLQDRLRAAHLLLDRSPPCPVVVDTMTNQSSSCYAALPERLYVLQEGRVLYKGKPGPWNYHPEEVRAVLEKLHS", "length": 248, "header": "tr|A0AAA9S815-1|A0AAA9S815_BOVIN Isoform 1 of Iodothyronine deiodinase OS=Bos taurus OX=9913 GN=DIO1 PE=3 SV=2 CANONICAL=A0AAA9S815-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S815-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815/entry#A0AAA9S815-1", "sequence": { "sequence": "MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQGNRPLVLNFGSCTPSFIFKFDQFKRLIEDFGSVADFLIIYIEEAHASDGWAFKNNVDIKNHRNLQDRLRAAHLLLDRSPPCPVVVDTMTNQSSSCYAALPERLYVLQEGRVLYKGKPGPWNYHPEEVRAVLEKLHS", "length": 248, "header": "tr|A0AAA9S815-1|A0AAA9S815_BOVIN Isoform 1 of Iodothyronine deiodinase OS=Bos taurus OX=9913 GN=DIO1 PE=3 SV=2 CANONICAL=A0AAA9S815-1" }, "locus": { "chromosome": "3", "start_pos": 92330689, "end_pos": 92311329, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091872.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091872.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081380.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081380.2" } ] } }, { "isoform_ac": "A0ABI0NZ86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815/entry#A0ABI0NZ86-1", "sequence": { "sequence": "MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQG", "length": 113, "header": "tr|A0ABI0NZ86-1|A0ABI0NZ86_BOVIN Computationally mapped isoform of Iodothyronine deiodinase OS=Bos taurus OX=9913 GN=DIO1 PE=3 SV=1 CANONICAL=A0AAA9S815-1" }, "locus": { "chromosome": "3", "start_pos": 92330689, "end_pos": 92311393, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149562.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149562.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105742.1" } ] } }, { "isoform_ac": "A0ABI0P2T8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815/entry#A0ABI0P2T8-1", "sequence": { "sequence": "MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQGNRPLVLNFGSCTPSFIFKFDQFKRLIEDFGSVADFLIIYIEEAHASG", "length": 160, "header": "tr|A0ABI0P2T8-1|A0ABI0P2T8_BOVIN Computationally mapped isoform of Iodothyronine deiodinase OS=Bos taurus OX=9913 GN=DIO1 PE=3 SV=1 CANONICAL=A0AAA9S815-1" }, "locus": { "chromosome": "3", "start_pos": 92330689, "end_pos": 92311393, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105025.1" } ] } }, { "isoform_ac": "A0ABI0P2V0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815/entry#A0ABI0P2V0-1", "sequence": { "sequence": "MGLPSPGLWLKRLWVLFQVALHVAIGKVLLTLFPRRVKQNILAMGEKTGMTRNPHFSHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCSIWDFMQDGWAFKNNVDIKNHRNLQDRLRAAHLLLDRSPPCPVVVDTMTNQSSSCYAALPERLYVLQEGRVLYKGKPGPWNYHPEEVRAVLEKLHS", "length": 201, "header": "tr|A0ABI0P2V0-1|A0ABI0P2V0_BOVIN Computationally mapped isoform of Iodothyronine deiodinase OS=Bos taurus OX=9913 GN=DIO1 PE=3 SV=1 CANONICAL=A0AAA9S815-1" }, "locus": { "chromosome": "3", "start_pos": 92330689, "end_pos": 92311329, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152163.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152163.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105429.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105429.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thyroxine 5-deiodinase activity", "id": "GO:0033798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033798", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" }, { "name": "thyroxine 5'-deiodinase activity", "id": "GO:0004800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004800", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "thyroid hormone catabolic process", "id": "GO:0042404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042404", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" }, { "name": "hormone biosynthetic process", "id": "GO:0042446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042446", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" }, { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S815", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S815" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18897", "name": "", "equation": "3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B1-1" ], "evidence": [ { "id": "18897", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18897" } ] }, { "id": "82571", "name": "", "equation": "3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B1-1" ], "evidence": [ { "id": "82571", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/82571" } ] }, { "id": "82575", "name": "", "equation": "3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B2-1" ], "evidence": [ { "id": "82575", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/82575" } ] }, { "id": "82895", "name": "", "equation": "3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B1-1" ], "evidence": [ { "id": "82895", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/82895" } ] }, { "id": "82899", "name": "", "equation": "3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B2-1" ], "evidence": [ { "id": "82899", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/82899" } ] }, { "id": "83751", "name": "", "equation": "3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "83751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83751" } ] }, { "id": "83783", "name": "", "equation": "3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "83783", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83783" } ] }, { "id": "83795", "name": "", "equation": "3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B2-1" ], "evidence": [ { "id": "83795", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83795" } ] }, { "id": "83803", "name": "", "equation": "3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B2-1" ], "evidence": [ { "id": "83803", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83803" } ] }, { "id": "83811", "name": "", "equation": "3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5-triiodothyronamine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B1-1" ], "evidence": [ { "id": "83811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83811" } ] }, { "id": "83823", "name": "", "equation": "3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I3B1-1" ], "evidence": [ { "id": "83823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83823" } ] }, { "id": "83827", "name": "", "equation": "3-iodothyronamine + iodide + A + H(+) = 3,3'-diiodothyronamine + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "83827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83827" } ] }, { "id": "83831", "name": "", "equation": "3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "83831", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83831" } ] }, { "id": "83835", "name": "", "equation": "3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "83835", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83835" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q5I3B1", "gene_name": "DIO3", "activity": [ { "ec_number": "1.21.99.3", "activity": "3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2.", "evidence": [ { "id": "Q5I3B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I3B1" } ] }, { "ec_number": "1.21.99.3", "activity": "", "evidence": [ { "id": "Q5I3B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I3B1" } ] } ] }, { "uniprot_ac": "Q5I3B2", "gene_name": "DIO2", "activity": [ { "ec_number": "1.21.99.4", "activity": "3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2.", "evidence": [ { "id": "Q5I3B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I3B2" } ] }, { "ec_number": "1.21.99.4", "activity": "", "evidence": [ { "id": "Q5I3B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I3B2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S889-1", "uniprot_ac": "A0AAA9S889", "uniprot_id": "A0AAA9S889_BOVIN", "mass": { "chemical_mass": 32998.0, "monoisotopic_mass": 32998.0 }, "refseq": {}, "gene_names": [ { "name": "ALKAL1", "type": "recommended", "evidence": [ { "id": "A0AAA9S889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889" } ] } ], "protein_names": [ { "name": "ALK and LTK ligand 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S889", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALKAL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889", "locus": {} } ], "crossref": [ { "id": "A0AAA9S889", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S889", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28676", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28676", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28676:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28676:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S889", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S889-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0V6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LPSARLGGGKGYHAGPRARVCGGREGAAVLHPLTTQAQVGGAGGAPGWGRGWGRGSSSGDPHLSDWEPRLCRRAPLPRYSPRSRPGSCRLSRAGWAGRGGRQSGPCAGSPDTRRAKAGSSERLRVPVSIRALGLALFPSAAPSPRPASAPCVPPRGAQVSPAVCPLGADPPPGTRLLSGRSRAPMRPARPGAPVPALLLLALVLALRGTQGRPGGSRGAHVAGEEPKPSLPAASRSAEIFPRDLNLKDKFIKHFTGPVTFSAECSKHFHRLYHNTRDCSTPAYYKRCARLLKRLAVSPLCSQTEKTYVHFLRM", "length": 313, "header": "tr|A0AAA9S889-1|A0AAA9S889_BOVIN Isoform 1 of ALK and LTK ligand 1 OS=Bos taurus OX=9913 GN=ALKAL1 PE=3 SV=1 CANONICAL=A0AAA9S889-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S889-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889/entry#A0AAA9S889-1", "sequence": { "sequence": "LPSARLGGGKGYHAGPRARVCGGREGAAVLHPLTTQAQVGGAGGAPGWGRGWGRGSSSGDPHLSDWEPRLCRRAPLPRYSPRSRPGSCRLSRAGWAGRGGRQSGPCAGSPDTRRAKAGSSERLRVPVSIRALGLALFPSAAPSPRPASAPCVPPRGAQVSPAVCPLGADPPPGTRLLSGRSRAPMRPARPGAPVPALLLLALVLALRGTQGRPGGSRGAHVAGEEPKPSLPAASRSAEIFPRDLNLKDKFIKHFTGPVTFSAECSKHFHRLYHNTRDCSTPAYYKRCARLLKRLAVSPLCSQTEKTYVHFLRM", "length": 313, "header": "tr|A0AAA9S889-1|A0AAA9S889_BOVIN Isoform 1 of ALK and LTK ligand 1 OS=Bos taurus OX=9913 GN=ALKAL1 PE=3 SV=1 CANONICAL=A0AAA9S889-1" }, "locus": { "chromosome": "14", "start_pos": 21461164, "end_pos": 21448440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106349.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106349.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082261.1" } ] } }, { "isoform_ac": "A0AAA9U0V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889/entry#A0AAA9U0V6-1", "sequence": { "sequence": "MRPARPGAPVPALLLLALVLALRGTQGRPGGSRGAHVAGEEPKPSLPAASRSAEIFPRDLNLKDKFIKHFTGPVTFSAECSKHFHRLYHNTRDCSTPACIS", "length": 101, "header": "tr|A0AAA9U0V6-1|A0AAA9U0V6_BOVIN Computationally mapped isoform of ALK and LTK ligand 1 OS=Bos taurus OX=9913 GN=ALKAL1 PE=3 SV=1 CANONICAL=A0AAA9S889-1" }, "locus": { "chromosome": "14", "start_pos": 21460612, "end_pos": 21448448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112842.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112842.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103321.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103321.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S889", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S889", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889" } ], "pmid": "" }, { "name": "receptor tyrosine kinase binding", "id": "GO:0030971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S889", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889" } ], "pmid": "" }, { "name": "receptor signaling protein tyrosine kinase activator activity", "id": "GO:0030298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030298", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S889", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S889" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S897-1", "uniprot_ac": "A0AAA9S897", "uniprot_id": "A0AAA9S897_BOVIN", "mass": { "chemical_mass": 89395.0, "monoisotopic_mass": 89395.0 }, "refseq": { "ac": "XP_059739741", "name": "zinc finger protein 41 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739741" }, "gene_names": [ { "name": "ZNF41", "type": "recommended", "evidence": [ { "id": "A0AAA9S897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ] }, { "name": "ZNF41", "type": "synonym", "evidence": [ { "id": "XP_059739741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739741" } ] } ], "protein_names": [ { "name": "Zinc finger protein 41", "type": "synonym", "evidence": [ { "id": "A0AAA9S897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 41 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059739741", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739741" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897", "locus": { "chromosome": "X", "start_pos": 85769991, "end_pos": 85813006, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002113", "url": "https://www.ensembl.org/id/ENSBTAG00000002113" } ] } } ], "crossref": [ { "id": "A0AAA9S897", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S897", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531674", "url": "https://www.ncbi.nlm.nih.gov/gene/531674", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N471", "url": "https://www.orthodb.org/?gene=F1N471", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059739741", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739741", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S897-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N471", "url": "https://www.uniprot.org/uniprotkb/F1N471", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N471-1", "url": "https://www.uniprot.org/uniprotkb/F1N471-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAIQSYPQWSPDLAAEGQGSMCEVSFEDVTVDFSQEEWQHLDPVQQRLYWDVTLETYSHLCAVGYQVPKPEVIFRLEQGEGSWTLDKETPHHSCSDEDIGQTQQQRISGEVSFHCEKIGQSIGKDSLCSIIEELWQGNDQLERNQENRNNPLSHVKVLTKERGYEYKNIEKIIHVSTRLVPSIKRLHNFDTFGKSLKHTLNLHNHNKSNATKNFDKIFGNGNNFAHSSSFTKNENANIGTNSYELNQCEKHLDHKQVLAHHQKIHTGEKLYICTEYVNTFTQESHLFEHQRINAGEKSHECNKDENIFTQKPQIEVPQSVYTREKPFICIQCGKAFTLRSNLITHQKIHTGQKPYKCSECGKAFFHRSYLFRHMRIHTGEKPYECNECGRGFSQNSDLSIHQKTHTGEKHYACSECGKAFTRKSALRMHQRIHTGEKPYICTECGKAFIQKSHFNTHQRIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGEKPYICTECGKVFTHRTNLTTHQKTHTGEKPYMCAECGKAFSDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKSRLKIHQKSHIGERHYECNECGKAFIQKSTLSVHQRIHTGEKPYACPECGKAFIQKSHFIAHHRIHTGEKPYACSDCGKCFTKKSQLRVHQKIHTGEKPNICAECGKAFTDRSNLITHQKIHTREKPYKCSDCGKTFTWKSRLSIHQKSHTGERHYECSKCGKAFIQKATLSMHQIIHTRKKAYACTQCQKAFTDRSNLIKHQKTHSAEKL", "length": 775, "header": "tr|A0AAA9S897-1|A0AAA9S897_BOVIN Isoform 1 of Zinc finger protein 41 OS=Bos taurus OX=9913 GN=ZNF41 PE=3 SV=1 CANONICAL=A0AAA9S897-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S897-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897/entry#A0AAA9S897-1", "sequence": { "sequence": "MPAIQSYPQWSPDLAAEGQGSMCEVSFEDVTVDFSQEEWQHLDPVQQRLYWDVTLETYSHLCAVGYQVPKPEVIFRLEQGEGSWTLDKETPHHSCSDEDIGQTQQQRISGEVSFHCEKIGQSIGKDSLCSIIEELWQGNDQLERNQENRNNPLSHVKVLTKERGYEYKNIEKIIHVSTRLVPSIKRLHNFDTFGKSLKHTLNLHNHNKSNATKNFDKIFGNGNNFAHSSSFTKNENANIGTNSYELNQCEKHLDHKQVLAHHQKIHTGEKLYICTEYVNTFTQESHLFEHQRINAGEKSHECNKDENIFTQKPQIEVPQSVYTREKPFICIQCGKAFTLRSNLITHQKIHTGQKPYKCSECGKAFFHRSYLFRHMRIHTGEKPYECNECGRGFSQNSDLSIHQKTHTGEKHYACSECGKAFTRKSALRMHQRIHTGEKPYICTECGKAFIQKSHFNTHQRIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGEKPYICTECGKVFTHRTNLTTHQKTHTGEKPYMCAECGKAFSDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKSRLKIHQKSHIGERHYECNECGKAFIQKSTLSVHQRIHTGEKPYACPECGKAFIQKSHFIAHHRIHTGEKPYACSDCGKCFTKKSQLRVHQKIHTGEKPNICAECGKAFTDRSNLITHQKIHTREKPYKCSDCGKTFTWKSRLSIHQKSHTGERHYECSKCGKAFIQKATLSMHQIIHTRKKAYACTQCQKAFTDRSNLIKHQKTHSAEKL", "length": 775, "header": "tr|A0AAA9S897-1|A0AAA9S897_BOVIN Isoform 1 of Zinc finger protein 41 OS=Bos taurus OX=9913 GN=ZNF41 PE=3 SV=1 CANONICAL=A0AAA9S897-1" }, "locus": { "chromosome": "X", "start_pos": 85796103, "end_pos": 85770995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078376.1" } ] } }, { "isoform_ac": "F1N471-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897/entry#F1N471-1", "sequence": { "sequence": "LPRPCSVHRYLVSGAQPPQLPAPTVVKLLLRATSASWPKFDTYYSPRGKYPGSVTAGAGRCPQRTGGQRRRQVSFEDVTVDFSQEEWQHLDPVQQRLYWDVTLETYSHLCAVGYQVPKPEVIFRLEQGEGSWTLDKETPHHSCSDEDIGQTQQQRISGEVSFHCEKIGQSIGKDSLCSIIEELWQGNDQLERNQENRNNPLSHVKVLTKERGYEYKNIEKIIHVSTRLVPSIKRLHNFDTFGKSLKHTLNLHNHNKSNATKNFDKIFGNGNNFAHSSSFTKNENANIGTNSYELNQCEKHLDHKQVLAHHQKIHTGEKLYICTEYVNTFTQESHLFEHQRINAGEKSHECNKDENIFTQKPQIEVPQSVYTREKPFICIQCGKAFTLRSNLITHQKIHTGQKPYKCSECGKAFFHRSYLFRHMRIHTGEKPYECNECGRGFSQNSDLSIHQKTHTGEKHYACSECGKAFTRKSALRMHQRIHTGEKPYICTECGKAFIQKSHFNTHQRIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGEKPYICTECGKVFTHRTNLTTHQKTHTGEKPYMCAECGKAFSDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKSRLKIHQKSHIGERHYECNECGKAFIQKSTLSVHQRIHTGEKPYACPECGKAFIQKSHFIAHHRIHTGEKPYACSDCGKCFTKKSQLRVHQKIHTGEKPNICAECGKAFTDRSNLITHQKIHTREKPYKCSDCGKTFTWKSRLSIHQKSHTGERHYECSKCGKAFIQKATLSMHQIIHTRKKAYACTQCQKAFTDRSNLIKHQKTHSAEKL", "length": 823, "header": "tr|F1N471-1|F1N471_BOVIN Computationally mapped isoform of Zinc finger protein 41 OS=Bos taurus OX=9913 GN=ZNF41 PE=3 SV=3 CANONICAL=A0AAA9S897-1" }, "locus": { "chromosome": "X", "start_pos": 85813005, "end_pos": 85770995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002726.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002726.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002726.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002726.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S897", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 244, "end_pos": 271, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S897" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 96, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 510, "end_pos": 512 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8C5-1", "uniprot_ac": "A0AAA9S8C5", "uniprot_id": "A0AAA9S8C5_BOVIN", "mass": { "chemical_mass": 75003.0, "monoisotopic_mass": 75003.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF16", "type": "recommended", "evidence": [ { "id": "A0AAA9S8C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ] } ], "protein_names": [ { "name": "Zinc finger protein 16", "type": "synonym", "evidence": [ { "id": "A0AAA9S8C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5", "locus": { "chromosome": "14", "start_pos": 260620, "end_pos": 275766, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016203", "url": "https://www.ensembl.org/id/ENSBTAG00000016203" } ] } } ], "crossref": [ { "id": "A0AAA9S8C5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8C5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016203", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016203", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PWIPAAQ", "url": "https://omabrowser.org/oma/group/PWIPAAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJD3", "url": "https://www.orthodb.org/?gene=F1MJD3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24376", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24376", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24376:SF189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24376:SF189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJD3", "url": "https://www.uniprot.org/uniprotkb/F1MJD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJD3-1", "url": "https://www.uniprot.org/uniprotkb/F1MJD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVLSQCSPCLCTVSPSGHARSQPCPASEYALKRQQWSSQFLDHPLGPLEPRPLWSDAPAETHPGSALHGSLCCGDAEPGATSPHHQQPGWDTRTKGQEFVQKEEVSEDLESQVEISDSSGSDAPQTPELGGLHCGVEERDCGLPEDERQMHRPHQEGAFTLAQMLLRSPSGEREVDCDDIKSSCSWSPSPVECQGPPAEGRPHPLGIRSLPCSLDLPSCTGLHVAESPFICSECGKTFEGDPGLTQHQTGHTGHKSFICNECGRLFSTHTGFLQHQLTHHGEKLHMCSECGKAFCQSSSLKKHQKSHVSEKPYECSECGKTFRRSSNLIQHQRIHSGEKPYVCHACGKAFRRSSNLVKHQRVHTGEKPFECTECGRAFSQSSHMRKHQRVHTGERPYSCSECGKPFSRVSNLIKHHRVHTGEKPYKCSECGKAFSQSSSLIQHRRIHTGEKPHVCAVCGKAFSYSSVLRKHQIIHTGEKPYECGVCGKAFSHSSALVQHQGVHTGDKPYECRECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYQCSECGKSFSQRSVLIQHQRIHTGVKPYDCTACGKAFSQRSKLTKHQLIHTRE", "length": 675, "header": "tr|A0AAA9S8C5-1|A0AAA9S8C5_BOVIN Isoform 1 of Zinc finger protein 16 OS=Bos taurus OX=9913 GN=ZNF16 PE=3 SV=1 CANONICAL=A0AAA9S8C5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5/entry#A0AAA9S8C5-1", "sequence": { "sequence": "MSVLSQCSPCLCTVSPSGHARSQPCPASEYALKRQQWSSQFLDHPLGPLEPRPLWSDAPAETHPGSALHGSLCCGDAEPGATSPHHQQPGWDTRTKGQEFVQKEEVSEDLESQVEISDSSGSDAPQTPELGGLHCGVEERDCGLPEDERQMHRPHQEGAFTLAQMLLRSPSGEREVDCDDIKSSCSWSPSPVECQGPPAEGRPHPLGIRSLPCSLDLPSCTGLHVAESPFICSECGKTFEGDPGLTQHQTGHTGHKSFICNECGRLFSTHTGFLQHQLTHHGEKLHMCSECGKAFCQSSSLKKHQKSHVSEKPYECSECGKTFRRSSNLIQHQRIHSGEKPYVCHACGKAFRRSSNLVKHQRVHTGEKPFECTECGRAFSQSSHMRKHQRVHTGERPYSCSECGKPFSRVSNLIKHHRVHTGEKPYKCSECGKAFSQSSSLIQHRRIHTGEKPHVCAVCGKAFSYSSVLRKHQIIHTGEKPYECGVCGKAFSHSSALVQHQGVHTGDKPYECRECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYQCSECGKSFSQRSVLIQHQRIHTGVKPYDCTACGKAFSQRSKLTKHQLIHTRE", "length": 675, "header": "tr|A0AAA9S8C5-1|A0AAA9S8C5_BOVIN Isoform 1 of Zinc finger protein 16 OS=Bos taurus OX=9913 GN=ZNF16 PE=3 SV=1 CANONICAL=A0AAA9S8C5-1" }, "locus": { "chromosome": "14", "start_pos": 274490, "end_pos": 261624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092244.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092244.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082297.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082297.1" } ] } }, { "isoform_ac": "F1MJD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5/entry#F1MJD3-1", "sequence": { "sequence": "MTPMHRRSQPCPASEYALKRQQWSSQFLDHPLGPLEPRPLWSDAPAETHPGSALHGSLCCGDAEPGATSPHHQQPGWDTRTKGQEFVQKEEVSEDLESQVEISDSSGSDAPQTPELGGLHCGVEERDCGLPEDERQMHRPHQEGAFTLAQMLLRSPSGEREVDCDDIKSSCSWSPSPVECQGPPAEGRPHPLGIRSLPCSLDLPSCTGLHVAESPFICSECGKTFEGDPGLTQHQTGHTGHKSFICNECGRLFSTHTGFLQHQLTHHGEKLHMCSECGKAFCQSSSLKKHQKSHVSEKPYECSECGKTFRRSSNLIQHQRIHSGEKPYVCHACGKAFRRSSNLVKHQRVHTGEKPFECTECGRAFSQSSHMRKHQRVHTGERPYSCSECGKPFSRVSNLIKHHRVHTGEKPYKCSECGKAFSQSSSLIQHRRIHTGEKPHVCAVCGKAFSYSSVLRKHQIIHTGEKPYECGVCGKAFSHSSALVQHQGVHTGDKPYECRECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYQCSECGKSFSQRSVLIQHQRIHTGVKPYDCTACGKAFSQRSKLTKHQLIHTRE", "length": 661, "header": "tr|F1MJD3-1|F1MJD3_BOVIN Computationally mapped isoform of Zinc finger protein 16 OS=Bos taurus OX=9913 GN=ZNF16 PE=3 SV=3 CANONICAL=A0AAA9S8C5-1" }, "locus": { "chromosome": "14", "start_pos": 275647, "end_pos": 261624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052907.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052907.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049457.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049457.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P17020-1", "protein_name": "Zinc finger protein 16", "gene_name": "ZNF16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAACGTPCCSDTELEAICPHYQQPDCDTRTEDKEFLHKEDIHEDLESQAEISENYAGDVSQVPELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDSRFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNECGKTFQGNPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSDFSRHQSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPFSRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTGEKPYRCSVCGKAFSHSSALIQHQGVHTGDKPYACHECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYKCSECGKAFSQRSVLIQHQRIHTGVKPYDCAACGKAFSQRSKLIKHQLIHTRE", "length": 682 }, "evidence": [ { "id": "A0AAA9S8C5", "url": "https://omabrowser.org/oma/group/A0AAA9S8C5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 257, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 576, "end_pos": 578 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8E4-1", "uniprot_ac": "A0AAA9S8E4", "uniprot_id": "A0AAA9S8E4_BOVIN", "mass": { "chemical_mass": 35274.0, "monoisotopic_mass": 35274.0 }, "refseq": { "ac": "NP_001376807", "name": "olfactory receptor family 2 subfamily A member 66", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376807" }, "gene_names": [ { "name": "OR2A66", "type": "recommended", "evidence": [ { "id": "A0AAA9S8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4" } ] }, { "name": "OR2A66", "type": "synonym", "evidence": [ { "id": "NP_001376807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376807" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2A2", "type": "synonym", "evidence": [ { "id": "NP_001376807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376807" } ] }, { "name": "olfactory receptor family 2 subfamily A member 66", "type": "synonym", "evidence": [ { "id": "NP_001376807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376807" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376807" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2A66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4", "locus": { "chromosome": "4", "start_pos": 107458674, "end_pos": 107457742, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060882", "url": "https://www.ensembl.org/id/ENSBTAG00000060882" } ] } } ], "crossref": [ { "id": "A0AAA9S8E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15420", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15420", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511400", "url": "https://www.ncbi.nlm.nih.gov/gene/511400", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511400", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511400", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376807", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGNQSQITEFILVGFQLSKNMELLLFGIFSLLYVCNLLANGMILGLICFDPRLHSPMYFFLSHLAIIDISFPSSNLPTFLENLVKHTKSISFDPCTVQMLFNLTFGSIECLILLAMSYDRYVAICHPLQYTVIMNWRVCSILAIACWVCGFALALVQVILLLRLPFCGPQKVNHFLCDIRSVLKLACGDIWMNEMFLFADGVLILVGPLALVLVSYMHILWAILKIQSKEGRKKAFSTCSSHLCVVGFYFGLAMIVYMVPDNSQQEEHLKILFLFYTLFNPLLNPLVYSVRNAQVKAAFHRVLQKKRTM", "length": 310, "header": "tr|A0AAA9S8E4-1|A0AAA9S8E4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A66 PE=3 SV=1 CANONICAL=A0AAA9S8E4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4/entry#A0AAA9S8E4-1", "sequence": { "sequence": "MEGNQSQITEFILVGFQLSKNMELLLFGIFSLLYVCNLLANGMILGLICFDPRLHSPMYFFLSHLAIIDISFPSSNLPTFLENLVKHTKSISFDPCTVQMLFNLTFGSIECLILLAMSYDRYVAICHPLQYTVIMNWRVCSILAIACWVCGFALALVQVILLLRLPFCGPQKVNHFLCDIRSVLKLACGDIWMNEMFLFADGVLILVGPLALVLVSYMHILWAILKIQSKEGRKKAFSTCSSHLCVVGFYFGLAMIVYMVPDNSQQEEHLKILFLFYTLFNPLLNPLVYSVRNAQVKAAFHRVLQKKRTM", "length": 310, "header": "tr|A0AAA9S8E4-1|A0AAA9S8E4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A66 PE=3 SV=1 CANONICAL=A0AAA9S8E4-1" }, "locus": { "chromosome": "4", "start_pos": 107458671, "end_pos": 107457742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090682.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090682.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080197.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080197.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511400", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511400", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8H6-1", "uniprot_ac": "A0AAA9S8H6", "uniprot_id": "A0AAA9S8H6_BOVIN", "mass": { "chemical_mass": 23844.0, "monoisotopic_mass": 23844.0 }, "refseq": { "ac": "XP_005223383", "name": "cyclin-dependent kinase inhibitor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" }, "gene_names": [ { "name": "CDKN1A", "type": "recommended", "evidence": [ { "id": "A0AAA9S8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ] }, { "name": "CDKN1A", "type": "synonym", "evidence": [ { "id": "XP_005223383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" } ] }, { "name": "CIP1", "type": "synonym", "evidence": [ { "id": "XP_005223383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" } ] }, { "name": "SDI1", "type": "synonym", "evidence": [ { "id": "XP_005223383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" } ] }, { "name": "WAF1", "type": "synonym", "evidence": [ { "id": "XP_005223383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" } ] }, { "name": "p21", "type": "synonym", "evidence": [ { "id": "XP_005223383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" } ] } ], "protein_names": [ { "name": "Cyclin-dependent kinase inhibitor 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6/entry#names_and_taxonomy" } ] }, { "name": "CDK-interacting protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6/entry#names_and_taxonomy" } ] }, { "name": "cyclin-dependent kinase inhibitor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383" } ] }, { "name": "p21", "type": "synonym", "evidence": [ { "id": "A0AAA9S8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDKN1A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6", "locus": { "chromosome": "23", "start_pos": 10590589, "end_pos": 10573376, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008353", "url": "https://www.ensembl.org/id/ENSBTAG00000008353" } ] } } ], "crossref": [ { "id": "A0AAA9S8H6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8H6", "database": "AlphaFoldDB", "categories": [] }, { "id": "513497", "url": "https://www.ncbi.nlm.nih.gov/gene/513497", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46778", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46778", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46778:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46778:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02234", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02234", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005223383", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223383", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVLLRTSRAGSRGPDALGHSGAAGWKGPESLNHRHTWRSATCQPEQLYSLSTGAMSELSRDAHQIPRSSKACRCLFGPVDSEQLRQDCDALMASCVQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPVGPRDDLGGGKRPSPSSALLQGTSQEDHLDLSLSCTLVTRSPERPEGTPGGPGPSQGRKRRQTSMTDFYHSKRRLICSKRKP", "length": 216, "header": "tr|A0AAA9S8H6-1|A0AAA9S8H6_BOVIN Isoform 1 of Cyclin-dependent kinase inhibitor 1 OS=Bos taurus OX=9913 GN=CDKN1A PE=3 SV=1 CANONICAL=A0AAA9S8H6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6/entry#A0AAA9S8H6-1", "sequence": { "sequence": "MEVLLRTSRAGSRGPDALGHSGAAGWKGPESLNHRHTWRSATCQPEQLYSLSTGAMSELSRDAHQIPRSSKACRCLFGPVDSEQLRQDCDALMASCVQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPVGPRDDLGGGKRPSPSSALLQGTSQEDHLDLSLSCTLVTRSPERPEGTPGGPGPSQGRKRRQTSMTDFYHSKRRLICSKRKP", "length": 216, "header": "tr|A0AAA9S8H6-1|A0AAA9S8H6_BOVIN Isoform 1 of Cyclin-dependent kinase inhibitor 1 OS=Bos taurus OX=9913 GN=CDKN1A PE=3 SV=1 CANONICAL=A0AAA9S8H6-1" }, "locus": { "chromosome": "23", "start_pos": 10588828, "end_pos": 10573687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090218.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090218.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078458.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078458.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 182, "start_aa": "Thr", "end_pos": 182, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr182", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "PCNA-p21 complex", "id": "GO:0070557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070557", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "cellular response to UV-B", "id": "GO:0071493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071493", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "import into nucleus", "id": "GO:0051170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "positive regulation of reactive oxygen species metabolic process", "id": "GO:2000379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000379", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "negative regulation of DNA biosynthetic process", "id": "GO:2000279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000279", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "tissue regeneration", "id": "GO:0042246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "positive regulation of fibroblast proliferation", "id": "GO:0048146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway", "id": "GO:0097193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cellular senescence", "id": "GO:0090398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090398", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "wound healing", "id": "GO:0042060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "DNA damage response, signal transduction by p53 class mediator", "id": "GO:0030330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030330", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cellular response to cell-matrix adhesion", "id": "GO:0071460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071460", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "replicative senescence", "id": "GO:0090399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "negative regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904706", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "negative regulation of cardiac muscle tissue regeneration", "id": "GO:1905179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase inhibitor activity", "id": "GO:0004861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "cyclin binding", "id": "GO:0030332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030332", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" }, { "name": "molecular function activator activity", "id": "GO:0140677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H6" }, { "id": "PF02234", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-dependent kinase inhibitor", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 123, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 182 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8J2-1", "uniprot_ac": "A0AAA9S8J2", "uniprot_id": "A0AAA9S8J2_BOVIN", "mass": { "chemical_mass": 35513.0, "monoisotopic_mass": 35513.0 }, "refseq": {}, "gene_names": [ { "name": "SHISA4", "type": "recommended", "evidence": [ { "id": "A0AAA9S8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2" } ] } ], "protein_names": [ { "name": "Shisa family member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9S8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHISA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2", "locus": { "chromosome": "16", "start_pos": 80578808, "end_pos": 80582153, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059995", "url": "https://www.ensembl.org/id/ENSBTAG00000059995" } ] } } ], "crossref": [ { "id": "A0AAA9S8J2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8J2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31395", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31395:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "HQEQGFSGRGRRRARQLAGRGPRGPPQQGPAAAGAGRPGGTARTRTPARGVAGAEPGGRGAGAGSAQAGEPRPEQAERSRGAGGRAGPRSWAAASSCAPRARRAAPCRPPGSAGPRRSPRSRSWCWGRPWVRAGGAAGGLGARPGGAREIPAEPRRFRVRGKALAGEDCLWYLDRNGSWHPGFNCEFFTFCCGTCYQRYCCRDLSLLITERQQKHCLAFSPKTIAGIASAVILFVAVVASTISCFLCSCCYLYRRRQQLQSPFEGQEIPMTGVPVQPVYPYPQDPKAGPAPPQPGFMYPPSGPAPQYPLYPAGPPVYNPAAPPPYVPPQPSYPGA", "length": 335, "header": "tr|A0AAA9S8J2-1|A0AAA9S8J2_BOVIN Isoform 1 of Shisa family member 4 OS=Bos taurus OX=9913 GN=SHISA4 PE=4 SV=1 CANONICAL=A0AAA9S8J2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2/entry#A0AAA9S8J2-1", "sequence": { "sequence": "HQEQGFSGRGRRRARQLAGRGPRGPPQQGPAAAGAGRPGGTARTRTPARGVAGAEPGGRGAGAGSAQAGEPRPEQAERSRGAGGRAGPRSWAAASSCAPRARRAAPCRPPGSAGPRRSPRSRSWCWGRPWVRAGGAAGGLGARPGGAREIPAEPRRFRVRGKALAGEDCLWYLDRNGSWHPGFNCEFFTFCCGTCYQRYCCRDLSLLITERQQKHCLAFSPKTIAGIASAVILFVAVVASTISCFLCSCCYLYRRRQQLQSPFEGQEIPMTGVPVQPVYPYPQDPKAGPAPPQPGFMYPPSGPAPQYPLYPAGPPVYNPAAPPPYVPPQPSYPGA", "length": 335, "header": "tr|A0AAA9S8J2-1|A0AAA9S8J2_BOVIN Isoform 1 of Shisa family member 4 OS=Bos taurus OX=9913 GN=SHISA4 PE=4 SV=1 CANONICAL=A0AAA9S8J2-1" }, "locus": { "chromosome": "16", "start_pos": 80581976, "end_pos": 80579443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090017.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090017.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078474.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078474.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J2" }, { "id": "PF13908", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shisa N-terminal", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 216, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8K0-1", "uniprot_ac": "A0AAA9S8K0", "uniprot_id": "A0AAA9S8K0_BOVIN", "mass": { "chemical_mass": 196774.0, "monoisotopic_mass": 196774.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD26", "type": "recommended", "evidence": [ { "id": "A0AAA9S8K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain containing 26", "type": "synonym", "evidence": [ { "id": "A0AAA9S8K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8K0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0", "locus": { "chromosome": "13", "start_pos": 17640546, "end_pos": 17708305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008288", "url": "https://www.ensembl.org/id/ENSBTAG00000008288" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008288", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008288", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533620", "url": "https://www.ncbi.nlm.nih.gov/gene/533620", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BLC3", "url": "https://www.orthodb.org/?gene=E1BLC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3X6J9", "url": "https://www.orthodb.org/?gene=G3X6J9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24147:SF60", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24147:SF60", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14915", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14915", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8K0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLC3", "url": "https://www.uniprot.org/uniprotkb/E1BLC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLC3-1", "url": "https://www.uniprot.org/uniprotkb/E1BLC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6J9", "url": "https://www.uniprot.org/uniprotkb/G3X6J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6J9-1", "url": "https://www.uniprot.org/uniprotkb/G3X6J9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKIFGFGSKKGESPLGSSISPGRDGGHRINLQPGYRIRDKDLGKIHKAAIVGNVAKVQQILLLGKNGLNDRDKMNRTALHLACANGHSAVVTLLLERKCLLNLCDNENRTALMKAVECQEEECATLLLEHGADPNVMDVSGNTALHYAVFCQNISLAAKLLSYDANIEARNKDDLTPLSLAVSERKQQMVEFLAKKEANIHAVDKMQSIRQLISEYKEERPKTPPENSNPEDESSEEDSLSRFSNKPGVDSWPTSDDEDLDLETKNVLKPSLTKLMNASQQSRRNIEAKCGIVRPESTTFSEDNNSDSEIEDVVETIPEPSPGVQGFSHPAFPSAEPLPQPLKSLAGLGLTKEGATKPEIVDKESDTDIIERAPQEQINHDHLSSVDATHKNNRSDMMSALGLGEEEDIESPWDSESISESLPQKYVDLLSGAAGQRGKNTLNGQVEDVSYIPSCMIGSRNFKMAKLEEPRHVGIPVAHMDSPEKYPNVKPAVLVKDSVPSKTVGMKDLQTSSSDIHPVECVLLSPSCYSLACLPSPSLGLYLSAELDLEMTSEEEEEKPVGDKNNHSQVEEEKKKHKSSEVEISDNVCDTADESGLIQQRKSGGNSSQEFAAMENEGSDSSDPDVHRKEVKKKDNSKWTPEGCVTAPIFEKTDSLTGGLLHVNDDSILSEVDQDDDRPAKKTSNENNKVKEQINSVDDLDDLTQSSETASEDGELLYYKNSMLLIEQLDTGCKDSVSLLKIRDTILSYERLVELKKSHCELLKGKIKKMESKVRGLQKELSETKEVKSQLEHQKVEWERELGSLRFTLKQEEEQRRNADMLYEKIREQLRRKEDQYSKEVEMKQQLELTLRALEMELKTVRNDLNQVIEERNDTQKQLSRERNARILQDEILANHLAKQKEIEMANKEMNSEVSDSCEEAKDLLHKNHMLQEEIAMLRLEMDAVKIQNQEKEKKYFEDIEIVKGKNDDLQKAIKVNEETLTKTVSHYTGQLNALTAENTMLNSKLENEKESKQRLETEVESYRSRLAAASHDHDQCQTSKRDLELAFQRARDEWLHLQDKMKSDAANLKDNNEMLSQQLSRAESKFNNLEIKLHHTRDSLREKILMLERVQRDLSQTECQKQEIEHMYQNEQGKVNKYIGKQESLEERLSQLQSENMLLRQQLDDAQNKADSKEKTVISIQDQFQQIVRKLHAESEKQGLMLEERNKELVKECDHLKERMYQYENEKAEREAGVRQLQQELADTLKKQSMSEASLEVLSRYRANLEVEAQDLKKKLGQLTSQLQEAQDQLTEAVRCAEKTQDRVQKLEIENAELQTTVKKQAGKIEQLQKNLLSTRSSEDEKEQLKKYIELKQSLENSLDQEKKKNSELEKEITGFKKLLKMTRRKLNEYENGELSFHGDLKTSQTEMDIQINKLKHKIEDLTAELEAASSKCLHLDAKNQVLREELLSMKGMQKKCEKLEEKKKKLEQEVVHLRSHIEMNMIEHSQVEQYKREIEERARQDLVEKLKEVNLFLQIQAASQENLEQLQEKNNASIRSQMELRIKDLESELSKVKTLQEDSHKAELEKYKQLYLVELEVRKSLEGKLDKTHERLAVISTKLEVEKEQNRSLLSTLSTRPVLEPPCVGNFNNPVVLNGNLTPRANVGFSTSIPRPSNNSMETYLTKMRQELDRSITRELREAAAEFESESYGLSPLGATDGSNLSEDLLLKTSQEYVQILKKKYMI", "length": 1726, "header": "tr|A0AAA9S8K0-1|A0AAA9S8K0_BOVIN Isoform 1 of Ankyrin repeat domain containing 26 OS=Bos taurus OX=9913 GN=ANKRD26 PE=4 SV=1 CANONICAL=A0AAA9S8K0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0/entry#A0AAA9S8K0-1", "sequence": { "sequence": "MKKIFGFGSKKGESPLGSSISPGRDGGHRINLQPGYRIRDKDLGKIHKAAIVGNVAKVQQILLLGKNGLNDRDKMNRTALHLACANGHSAVVTLLLERKCLLNLCDNENRTALMKAVECQEEECATLLLEHGADPNVMDVSGNTALHYAVFCQNISLAAKLLSYDANIEARNKDDLTPLSLAVSERKQQMVEFLAKKEANIHAVDKMQSIRQLISEYKEERPKTPPENSNPEDESSEEDSLSRFSNKPGVDSWPTSDDEDLDLETKNVLKPSLTKLMNASQQSRRNIEAKCGIVRPESTTFSEDNNSDSEIEDVVETIPEPSPGVQGFSHPAFPSAEPLPQPLKSLAGLGLTKEGATKPEIVDKESDTDIIERAPQEQINHDHLSSVDATHKNNRSDMMSALGLGEEEDIESPWDSESISESLPQKYVDLLSGAAGQRGKNTLNGQVEDVSYIPSCMIGSRNFKMAKLEEPRHVGIPVAHMDSPEKYPNVKPAVLVKDSVPSKTVGMKDLQTSSSDIHPVECVLLSPSCYSLACLPSPSLGLYLSAELDLEMTSEEEEEKPVGDKNNHSQVEEEKKKHKSSEVEISDNVCDTADESGLIQQRKSGGNSSQEFAAMENEGSDSSDPDVHRKEVKKKDNSKWTPEGCVTAPIFEKTDSLTGGLLHVNDDSILSEVDQDDDRPAKKTSNENNKVKEQINSVDDLDDLTQSSETASEDGELLYYKNSMLLIEQLDTGCKDSVSLLKIRDTILSYERLVELKKSHCELLKGKIKKMESKVRGLQKELSETKEVKSQLEHQKVEWERELGSLRFTLKQEEEQRRNADMLYEKIREQLRRKEDQYSKEVEMKQQLELTLRALEMELKTVRNDLNQVIEERNDTQKQLSRERNARILQDEILANHLAKQKEIEMANKEMNSEVSDSCEEAKDLLHKNHMLQEEIAMLRLEMDAVKIQNQEKEKKYFEDIEIVKGKNDDLQKAIKVNEETLTKTVSHYTGQLNALTAENTMLNSKLENEKESKQRLETEVESYRSRLAAASHDHDQCQTSKRDLELAFQRARDEWLHLQDKMKSDAANLKDNNEMLSQQLSRAESKFNNLEIKLHHTRDSLREKILMLERVQRDLSQTECQKQEIEHMYQNEQGKVNKYIGKQESLEERLSQLQSENMLLRQQLDDAQNKADSKEKTVISIQDQFQQIVRKLHAESEKQGLMLEERNKELVKECDHLKERMYQYENEKAEREAGVRQLQQELADTLKKQSMSEASLEVLSRYRANLEVEAQDLKKKLGQLTSQLQEAQDQLTEAVRCAEKTQDRVQKLEIENAELQTTVKKQAGKIEQLQKNLLSTRSSEDEKEQLKKYIELKQSLENSLDQEKKKNSELEKEITGFKKLLKMTRRKLNEYENGELSFHGDLKTSQTEMDIQINKLKHKIEDLTAELEAASSKCLHLDAKNQVLREELLSMKGMQKKCEKLEEKKKKLEQEVVHLRSHIEMNMIEHSQVEQYKREIEERARQDLVEKLKEVNLFLQIQAASQENLEQLQEKNNASIRSQMELRIKDLESELSKVKTLQEDSHKAELEKYKQLYLVELEVRKSLEGKLDKTHERLAVISTKLEVEKEQNRSLLSTLSTRPVLEPPCVGNFNNPVVLNGNLTPRANVGFSTSIPRPSNNSMETYLTKMRQELDRSITRELREAAAEFESESYGLSPLGATDGSNLSEDLLLKTSQEYVQILKKKYMI", "length": 1726, "header": "tr|A0AAA9S8K0-1|A0AAA9S8K0_BOVIN Isoform 1 of Ankyrin repeat domain containing 26 OS=Bos taurus OX=9913 GN=ANKRD26 PE=4 SV=1 CANONICAL=A0AAA9S8K0-1" }, "locus": { "chromosome": "13", "start_pos": 17708161, "end_pos": 17641395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135225.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135225.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080252.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080252.1" } ] } }, { "isoform_ac": "E1BLC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0/entry#E1BLC3-1", "sequence": { "sequence": "MKKIFGFGSKKGESPLGSSISPGRDGGHRINLQPGYRIRDKDLGKIHKAAIVGNVAKVQQILLLGKNGLNDRDKMNRTALHLACANGHSAVVTLLLERKCLLNLCDNENRTALMKAVECQEEECATLLLEHGADPNVMDVSGNTALHYAVFCQNISLAAKLLSYDANIEARNKDDLTPLSLAVSERKQQMVEFLAKKEANIHAVDKMQSIRQLISEYKEERPKTPPENSNPEDESSEEDSLSRFSNKPGVDSWPTSDDEDLDLETKNVLKPSLTKLMNASQQSRRNIEAKCGIVRPESTTFSEDNNSDSEIEDVVETIPEPSPGVQGFSHPAFPSAEPLPQPLKSLAGLGLTKEGATKPEIVDKESDTDIIERAPQEQINHDHLSSVDATHKNNRSDMMSALGLGEEEDIESPWDSESISESLPQKYVDLLSGAAGQRGKNTLNGQVEDVSYIPSCMIGSRNFKMAKLEEPRHVGIPVAHMDSPEKYPNVKPAVLVKDSVPSKTVGMKDLQTSSSDLSAELDLEMTSEEEEEKPVGDKNNHSQVEEEKKKHKSSEVEISDNVCDTADESGLIQQRKSGGNSSQEFAAMENEGSDSSDPDVHRKEVKKKDNSKWTPEGCVTAPIFEKTDSLTGGLLHVNDDSILSEVDQDDDRPAKKTSNENNKVKEQINSVDDLDDLTQSSETASEDGELLYYKNSMLLIEQLDTGCKDSVSLLKIRDTILSYERLVELKKSHCELLKGKIKKMESKVRGLQKELSETKEVKSQLEHQKVEWERELGSLRFTLKQEEEQRRNADMLYEKIREQLRRKEDQYSKEVEMKQQLELTLRALEMELKTVRNDLNQVIEERNDTQKQLSRERNARILQDEILANHLAKQKEIEMANKEMNSEVSDSCEEAKDLLHKNHMLQEEIAMLRLEMDAVKIQNQEKEKKYFEDIEIVKGKNDDLQKAIKVNEETLTKTVSHYTGQLNALTAENTMLNSKLENEKESKQRLETEVESYRSRLAAASHDHDQCQTSKRDLELAFQRARDEWLHLQDKMKSDAANLKDNNEMLSQQLSRAESKFNNLEIKLHHTRDSLREKILMLERVQRDLSQTECQKQEIEHMYQNEQGKVNKYIGKQESLEERLSQLQSENMLLRQQLDDAQNKADSKEKTVISIQDQFQQIVRKLHAESEKQGLMLEERNKELVKECDHLKERMYQYENEKAEREAGVRQLQQELADTLKKQSMSEASLEVLSRYRANLEVEAQDLKKKLGQLTSQLQEAQDQLTEAVRCAEKTQDRVQKLEIENAELQTTVKKQAGKIEQLQKNLLSTRSSEDEKEQLKKYIELKQSLENSLDQEKKKNSELEKEITGFKKLLKMTRRKLNEYENGELSFHGDLKTSQTEMDIQINKLKHKIEDLTAELEAASSKCLHLDAKNQVLREELLSMKGMQKKCEKLEEKKKKLEQEVVHLRSHIEMNMIEHSQVEQYKREIEERARQDLVEKLKEVNLFLQIQAASQENLEQLQEKNNASIRSQMELRIKDLESELSKVKTLQEDSHKAELEKYKQLYLVELEVRKSLEGKLDKTHERLAVISTKLEVEKEQNRSLLSTLSTRPVLEPPCVGNFNNPVVLNGNLTPRANVGFSTSIPRPSNNSMETYLTKMRQELDRSITRELREAAAEFESESYGLSPLGATDGSNLSEDLLLKTSQEYVQILKKKYMI", "length": 1699, "header": "tr|E1BLC3-1|A0AAA9S8K0_BOVIN Computationally mapped isoform of Ankyrin repeat domain containing 26 OS=Bos taurus OX=9913 GN=ANKRD26 PE=4 SV=4 CANONICAL=A0AAA9S8K0-1" }, "locus": { "chromosome": "13", "start_pos": 17708161, "end_pos": 17641395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022622.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022622.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022622.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022622.7" } ] } }, { "isoform_ac": "G3X6J9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0/entry#G3X6J9-1", "sequence": { "sequence": "MKKIFGFGSKKGESPLGSSISPGRDGGHRINLQPGYRIRDKDLGKIHKAAIVGNVAKVQQILLLGKNGLNDRDKMNRTALHLACANGHSAVVTLLLERKCLLNLCDNENRTALMKAVECQEEECATLLLEHGADPNVMDVSGNTALHYAVFCQNISLAAKLLSYDANIEARNKDDLTPLSLAVSERKQQMVEFLAKKEANIHAVDKMQSIRQLISEYKEERPKTPPENSNPEDESSEEDSLSRFSNKPGVDSWPTSDDEDLDLETKNVLKPSLTKLMNASQQSRRNIEAKCGIVRPESTTFSEDNNSDSEIEDVVETIPEPSPGVQGFSHPAFPSAEPLPQPLKSLAGLGLTKEGATKPEIVDKESDTDIIERAPQEQINHDHLSSVDATHKNNRSDMMSALGLGEEEDIESPWDSESISESLPQKYVDLLSGAAGQRGKNTLNGQVEDSPEKYPNVKPAVLVKDSVPSKTVGMKDLQTSSSDLSAELDLEMTSEEEEEKPVGDKNNHSQVEEEKKKHKSSEVEISDNVCDTADESGLIQQRKSGGNSSQEFAAMENEGSDSSDPDVHRKEVKKKDNSKWTPEGCVTAPIFEKTDSLTGGLLHVNDDSILSEVDQDDDRPAKKTSNENNKVKEQINSVDDLDDLTQSSETASEDGELLYYKNSMLLIEQLDTGCKDSVSLLKIRDTILSYERLVELKKSHCELLKGKIKKMESKVRGLQKELSETKEVKSQLEHQKVEWERELGSLRFTLKQEEEQRRNADMLYEKIREQLRRKEDQYSKEVEMKQQLELTLRALEMELKTVRNDLNQVIEERNDTQKQLSRERNARILQDEILANHLAKQKEIEMANKEMNSEVSDSCEEAKDLLHKNHMLQEEIAMLRLEMDAVKIQNQEKEKKYFEDIEIVKGKNDDLQKAIKVNEETLTKTVSHYTGQLNALTAENTMLNSKLENEKESKQRLETEVESYRSRLAAASHDHDQCQTSKRDLELAFQRARDEWLHLQDKMKSDAANLKDNNEMLSQQLSRAESKFNNLEIKLHHTRDSLREKILMLERVQRDLSQTECQKQEIEHMYQNEQGKVNKYIGKQESLEERLSQLQSENMLLRQQLDDAQNKADSKEKTVISIQDQFQQIVRKLHAESEKQGLMLEERNKELVKECDHLKERMYQYENEKAEREAGVRQLQQELADTLKKQSMSEASLEVLSRYRANLEVEAQDLKKKLGQLTSQLQEAQDQLTEAVRCAEKTQDRVQKLEIENAELQTTVKKQAGKIEQLQKNLLSTRSSEDEKEQLKKYIELKQSLENSLDQEKKKNSELEKEITGFKKLLKMTRRKLNEYENGELSFHGDLKTSQTEMDIQINKLKHKIEDLTAELEAASSKCLHLDAKNQVLREELLSMKGMQKKCEKLEEKKKKLEQEVVHLRSHIEMNMIEHSQVEQYKREIEERARQDLVEKLKEVNLFLQIQAASQENLEQLQEKNNASIRSQMELRIKDLESELSKVKTLQEDSHKAELEKYKQLYLVELEVRKSLEGKLDKTHERLAVISTKLEVEKEQNRSLLSTLSTRPVLEPPCVGNFNNPVVLNGNLTPRANVGFSTSIPRPSNNSMETYLTKMRQELDRSITRELREAAAEFESESYGLSPLGATDGSNLSEDLLLKTSQEYVQILKKKYMI", "length": 1666, "header": "tr|G3X6J9-1|G3X6J9_BOVIN Computationally mapped isoform of Ankyrin repeat domain containing 26 OS=Bos taurus OX=9913 GN=ANKRD26 PE=4 SV=3 CANONICAL=A0AAA9S8K0-1" }, "locus": { "chromosome": "13", "start_pos": 17708161, "end_pos": 17641395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008040.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008040.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008040.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008040.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9696264", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "resource": "Reactome", "description": "RND3 GTPase cycle" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" }, { "id": "R-BTA-9696273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "resource": "Reactome", "description": "RND1 GTPase cycle" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1534, "end_pos": 1536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1609, "end_pos": 1611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1639, "end_pos": 1641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1657, "end_pos": 1659, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1703, "end_pos": 1705, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" }, { "start_pos": 607, "end_pos": 609, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" }, { "start_pos": 874, "end_pos": 876, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0" }, { "id": "PF14915", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCDC144C-like coiled-coil", "eco_id": "ECO_0000259", "start_pos": 808, "end_pos": 1284, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K0" }, { "id": "PF12001", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF3496", "eco_id": "ECO_0000259", "start_pos": 1538, "end_pos": 1645, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 1534, "end_pos": 1536 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 1609, "end_pos": 1611 }, { "start_pos": 1639, "end_pos": 1641 }, { "start_pos": 1657, "end_pos": 1659 }, { "start_pos": 1703, "end_pos": 1705 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 394, "end_pos": 396 }, { "start_pos": 567, "end_pos": 569 }, { "start_pos": 607, "end_pos": 609 }, { "start_pos": 76, "end_pos": 78 }, { "start_pos": 874, "end_pos": 876 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8K3-1", "uniprot_ac": "A0AAA9S8K3", "uniprot_id": "A0AAA9S8K3_BOVIN", "mass": { "chemical_mass": 69493.0, "monoisotopic_mass": 69493.0 }, "refseq": { "ac": "XP_024856893", "name": "collagen alpha-3(IX) chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856893" }, "gene_names": [ { "name": "COL9A3", "type": "recommended", "evidence": [ { "id": "A0AAA9S8K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3" } ] }, { "name": "COL9A3", "type": "synonym", "evidence": [ { "id": "XP_024856893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856893" } ] } ], "protein_names": [ { "name": "Collagen type IX alpha 3 chain", "type": "synonym", "evidence": [ { "id": "A0AAA9S8K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3/entry#names_and_taxonomy" } ] }, { "name": "collagen alpha-3(IX) chain", "type": "synonym", "evidence": [ { "id": "XP_024856893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856893" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL9A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3", "locus": { "chromosome": "13", "start_pos": 54545391, "end_pos": 54564703, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015581", "url": "https://www.ensembl.org/id/ENSBTAG00000015581" } ] } } ], "crossref": [ { "id": "A0AAA9S8K3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8K3", "database": "AlphaFoldDB", "categories": [] }, { "id": "789493", "url": "https://www.ncbi.nlm.nih.gov/gene/789493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789493", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789493", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF866", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF866", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856893", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKPPPTQVGWLNGGLVRGPAGRELASGRPTTSPARRAQLEAPASAASSAQSATAAMAGAPTLALLLLGQLLAATVILTEAQKVGPRGPPGPQGPPGKPGKDGIDGEVGPPGLPGPVGPKGAPGKPGKPGEAGLPGLPGVDGLTGQDGPPGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGLPGGIGLRGPPGPSGLPGLPGPPGPPGPPGHPGVLPEGATDLQCPAICPPGPPGPPGMPGFKGPTGYKGEPGEVGKDGEKGDPGPPGPPGIPGTVGLQGPRGLRGLSGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKGDLGRPGPKGIPGMSGPSGEPGMPGKDGQDGVPGLDGEKGEAGRHGAPGEKGPNGLPGLPGRAGSKGEKGELGRPGELGEAGPSGEPGVPGDVGMPGERGEAGHRGSAGALGPQGPPGAPGVRGFQGRKGSIGDPGLPGPQGLRGGVGDRGPGGAAGPKGDQGIAGADGLPGDKGELGPSGPVGPKGESGSRGELGPKGIQGPNGTSGVDGVPGPPGPVGLQGVRGVPGITGKPGVPGKEASEQHIRELCGGLVSEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGNQGDRGDKGSAGEGLDGPDGDQGLQGPQGVPGISKDGRDGAHGEPGLPGDPGLPGAVGAQGPPGICDTSACQGAVMAAVGEKSGPRSS", "length": 740, "header": "tr|A0AAA9S8K3-1|A0AAA9S8K3_BOVIN Isoform 1 of Collagen type IX alpha 3 chain OS=Bos taurus OX=9913 GN=COL9A3 PE=4 SV=1 CANONICAL=A0AAA9S8K3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3/entry#A0AAA9S8K3-1", "sequence": { "sequence": "MQKPPPTQVGWLNGGLVRGPAGRELASGRPTTSPARRAQLEAPASAASSAQSATAAMAGAPTLALLLLGQLLAATVILTEAQKVGPRGPPGPQGPPGKPGKDGIDGEVGPPGLPGPVGPKGAPGKPGKPGEAGLPGLPGVDGLTGQDGPPGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGLPGGIGLRGPPGPSGLPGLPGPPGPPGPPGHPGVLPEGATDLQCPAICPPGPPGPPGMPGFKGPTGYKGEPGEVGKDGEKGDPGPPGPPGIPGTVGLQGPRGLRGLSGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKGDLGRPGPKGIPGMSGPSGEPGMPGKDGQDGVPGLDGEKGEAGRHGAPGEKGPNGLPGLPGRAGSKGEKGELGRPGELGEAGPSGEPGVPGDVGMPGERGEAGHRGSAGALGPQGPPGAPGVRGFQGRKGSIGDPGLPGPQGLRGGVGDRGPGGAAGPKGDQGIAGADGLPGDKGELGPSGPVGPKGESGSRGELGPKGIQGPNGTSGVDGVPGPPGPVGLQGVRGVPGITGKPGVPGKEASEQHIRELCGGLVSEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGNQGDRGDKGSAGEGLDGPDGDQGLQGPQGVPGISKDGRDGAHGEPGLPGDPGLPGAVGAQGPPGICDTSACQGAVMAAVGEKSGPRSS", "length": 740, "header": "tr|A0AAA9S8K3-1|A0AAA9S8K3_BOVIN Isoform 1 of Collagen type IX alpha 3 chain OS=Bos taurus OX=9913 GN=COL9A3 PE=4 SV=1 CANONICAL=A0AAA9S8K3-1" }, "locus": { "chromosome": "13", "start_pos": 54564504, "end_pos": 54546016, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098614.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098614.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078486.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789493", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789493", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "male gonad development", "id": "GO:0008584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3" } ], "pmid": "" }, { "name": "female gonad development", "id": "GO:0008585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008585", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 539, "end_pos": 541 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8L1-1", "uniprot_ac": "A0AAA9S8L1", "uniprot_id": "A0AAA9S8L1_BOVIN", "mass": { "chemical_mass": 42074.0, "monoisotopic_mass": 42074.0 }, "refseq": { "ac": "XP_005214994", "name": "protein FAM217B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214994" }, "gene_names": [ { "name": "FAM217B", "type": "recommended", "evidence": [ { "id": "A0AAA9S8L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1" } ] }, { "name": "FAM217B", "type": "synonym", "evidence": [ { "id": "XP_005214994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214994" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 217 member B", "type": "synonym", "evidence": [ { "id": "A0AAA9S8L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1/entry#names_and_taxonomy" } ] }, { "name": "protein FAM217B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214994" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM217B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1", "locus": { "chromosome": "13", "start_pos": 56599623, "end_pos": 56614384, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045509", "url": "https://www.ensembl.org/id/ENSBTAG00000045509" } ] } } ], "crossref": [ { "id": "ENSBTAG00000045509", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045509", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538877", "url": "https://www.ncbi.nlm.nih.gov/gene/538877", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538877", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538877", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RPSYYAF", "url": "https://omabrowser.org/oma/group/RPSYYAF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N0Y7", "url": "https://www.orthodb.org/?gene=G3N0Y7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22145:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22145:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214994", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0Y7", "url": "https://www.uniprot.org/uniprotkb/G3N0Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0Y7-1", "url": "https://www.uniprot.org/uniprotkb/G3N0Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNAGPSRTKVQHPKNSRKRQSKPQVPHISSQLKSSLRGGVPQPTEDKLKESISPEGNPERSPLGPRYHGLSGNKLFLDFESMKIIKEDDEEEDSASDLSDSERIAIPPSPLTPPDLHLRAEEIDPVHFDLHPGQGPTWPEYCYPDFLPPPCNSWDLRDMAMLLHSERRTEAVPKTGGLLGKYIDRLVQLEWLQIQTIQCEKGKVAKGRPPTGTSGALKSPGRSKLMPSALSRPHQEGPLKSGPSRKKDMLCKEVHPFCYTGEASPRPLDVLSSSRLCSQKQTPEVQTEKKKKKSNKSPRLQPWDLSCGDGGPKIESNGNLRAPRPPAMILDPTDGCRAARAPAHTGLKKKGNVSHCAHATISSEKKLKTNGGKQNTYKFKK", "length": 381, "header": "tr|A0AAA9S8L1-1|A0AAA9S8L1_BOVIN Isoform 1 of Family with sequence similarity 217 member B OS=Bos taurus OX=9913 GN=FAM217B PE=4 SV=1 CANONICAL=A0AAA9S8L1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1/entry#A0AAA9S8L1-1", "sequence": { "sequence": "MNAGPSRTKVQHPKNSRKRQSKPQVPHISSQLKSSLRGGVPQPTEDKLKESISPEGNPERSPLGPRYHGLSGNKLFLDFESMKIIKEDDEEEDSASDLSDSERIAIPPSPLTPPDLHLRAEEIDPVHFDLHPGQGPTWPEYCYPDFLPPPCNSWDLRDMAMLLHSERRTEAVPKTGGLLGKYIDRLVQLEWLQIQTIQCEKGKVAKGRPPTGTSGALKSPGRSKLMPSALSRPHQEGPLKSGPSRKKDMLCKEVHPFCYTGEASPRPLDVLSSSRLCSQKQTPEVQTEKKKKKSNKSPRLQPWDLSCGDGGPKIESNGNLRAPRPPAMILDPTDGCRAARAPAHTGLKKKGNVSHCAHATISSEKKLKTNGGKQNTYKFKK", "length": 381, "header": "tr|A0AAA9S8L1-1|A0AAA9S8L1_BOVIN Isoform 1 of Family with sequence similarity 217 member B OS=Bos taurus OX=9913 GN=FAM217B PE=4 SV=1 CANONICAL=A0AAA9S8L1-1" }, "locus": { "chromosome": "13", "start_pos": 56603934, "end_pos": 56602792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127111.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127111.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075941.1" } ] } }, { "isoform_ac": "A0AAA9TGI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1/entry#A0AAA9TGI8-1", "sequence": { "sequence": "MPRSEQVTRSRHTSWRPRRSPKSGASTGGGKSGTRHCRVNSRSWLLQHSSGGKAPCPNIRGGKKSLPLLSASSNRLSKNISSTTEKTVYPTLNDDQPCDCFKKGNRVNESYQKTSNMNAGPSRTKVQHPKNSRKRQSKPQVPHISSQLKSSLRGGVPQPTEDKLKESISPEGNPERSPLGPRYHGLSGNKLFLDFESMKIIKEDDEEEDSASDLSDSERIAIPPSPLTPPDLHLRAEEIDPVHFDLHPGQGPTWPEYCYPDFLPPPCNSWDLRDMAMLLHSERRTEAVPKTGGLLGKYIDRLVQLEWLQIQTIQCEKGKVAKGRPPTGTSGALKSPGRSKLMPSALSRPHQEGPLKSGPSRKKDMLCKEVHPFCYTGEASPRPLDVLSSSRLCSQKQTPEVQTEKKKKKSNKSPRLQPWDLSCGDGGPKIESNGNLRAPRPPAMILDPTDGCRAARAPAHTGLKKKGNVSHCAHATISSEKKLKTNGGKQNTYKFKK", "length": 497, "header": "tr|A0AAA9TGI8-1|A0AAA9TGI8_BOVIN Computationally mapped isoform of Family with sequence similarity 217 member B OS=Bos taurus OX=9913 GN=FAM217B PE=4 SV=1 CANONICAL=A0AAA9S8L1-1" }, "locus": { "chromosome": "13", "start_pos": 56608939, "end_pos": 56602792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091725.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091725.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097302.1" } ] } }, { "isoform_ac": "G3N0Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L1/entry#G3N0Y7-1", "sequence": { "sequence": "MRRRNRRAVSLPTLRPLLWCPGTCSATLGRVRCNRRCRGRSGPAARSPRPPPGPSSPPPGFPLWARKKKKKAGFQDKCLLARTLLGAAAERRVAAAALGFLRVRGRECPPRGPAQRPLPGRALLTRPRLVGATSRRASAPPLVTRPARTPAAQRSRLPPAQPRVTCPPRPRNSSGGKAPCPNIRGGKKSLPLLSASSNRLSKNISSTTEKTVYPTLNDDQPCDCFKKGNRVNESYQKTSNMNAGPSRTKVQHPKNSRKRQSKPQVPHISSQLKSSLRGGVPQPTEDKLKESISPEGNPERSPLGPRYHGLSGNKLFLDFESMKIIKEDDEEEDSASDLSDSERIAIPPSPLTPPDLHLRAEEIDPVHFDLHPGQGPTWPEYCYPDFLPPPCNSWDLRDMAMLLHSERRTEAVPKTGGLLGKYIDRLVQLEWLQIQTIQCEKGKVAKGRPPTGTSGALKSPGRSKLMPSALSRPHQEGPLKSGPSRKKDMLCKEVHPFCYTGEASPRPLDVLSSSRLCSQKQTPEVQTEKKKKKSNKSPRLQPWDLSCGDGGPKIESNGNLRAPRPPAMILDPTDGCRAARAPAHTGLKKKGNVSHCAHATISSEKKLKTNGGKQNTYKFKK", "length": 621, "header": "tr|G3N0Y7-1|G3N0Y7_BOVIN Computationally mapped isoform of Family with sequence similarity 217 member B OS=Bos taurus OX=9913 GN=FAM217B PE=4 SV=2 CANONICAL=A0AAA9S8L1-1" }, "locus": { "chromosome": "13", "start_pos": 56608352, "end_pos": 56602792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066184.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066184.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055507.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055507.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 112, "start_aa": "Thr", "end_pos": 112, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr112", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 137, "start_aa": "Thr", "end_pos": 137, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr137", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538877", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538877", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LU95-1", "protein_name": "Protein FAM217B", "gene_name": "Fam217b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDFHQKSSMNAGSSWNQEQHSKTSSGKRQSRSQGLQASSHLGSSLLGISQPAADKLIRTISTEGRQDQERTVLSSRCQAASGSKLFLEFQSMKIIKDGTDEDSASDLSDSERVAIPPSPFTPPDLNLRAEEIDPVSFSLYPDPRLAEPEHCYPDFLPPPFSSWDLQDMAVAMNTECRSEALPRATGFLGKYIDRLLQLEWLQVQTVQCEKARAAKARPPGASGMLKSPRRGKLLTSVLSKPLLSPEGIPKPGPSRKKGFHHEEIHPSYYTFETSPRSVDGPGRPRLCSQKQAPEVRMEKKKKSSKAPKLHLCAPPCAEGSPALEANGNIRIPTKSAVLDPRDSCGASRSQAHLDLKKKGNANNYGLTSSSREKKLKTNGGKQSMYKLK", "length": 389 }, "evidence": [ { "id": "A0AAA9S8L1", "url": "https://omabrowser.org/oma/group/A0AAA9S8L1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2AJW5-1", "protein_name": "Family with sequence similarity 217, member B", "gene_name": "Fam217b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRDCHQKSSINAGSSWNQVQHSKTTSGKRQSGSQGPHVSSQLRSSLLGISQPAAEKLMETVPTEGIQEQAALSSRYQAASGSKLFLDFHSMEIMKGADEDSASDLSDSERVAIPPSPFTPPELNLRAEEIDPVSFSLHPELSQAESRQTYPDFLPPPFNSWDLRDMAVVMNSECRSEALPRATGFLGKYIDRLLQLEWLQVQTVQCEKARAAKAKPPGASGVLKSPGRGKLLTSALSKPLPSPEGISKSGPSRKKGFRHEEAHPSYYAFETLPNSVDGPGRPRLCSQKQAPELRMEKKKKSSKGPKLQPRAPPCAEGNPAMEANGNIRIPRQSAVLLDPVDSHRASRTQAHVDLKKKGSANTCGYAPSSSEKKLKTNGAKQSTYKLK", "length": 387 }, "evidence": [ { "id": "A0AAA9S8L1", "url": "https://omabrowser.org/oma/group/A0AAA9S8L1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZSF0-1", "protein_name": "Family with sequence similarity 217, member B", "gene_name": "Fam217b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLEGRLPSVSLLSVFFCFQFRWLFSFSEDKGNKEVTSPAVIIRQQIEQEDSEHCREEGRAAAKGCSINAGSSWNQVQPLKISSGKRPSELQGPRVSSQPRSSLLGISQPAADKLVETIPREGRQEQAELSSRYQAASGGRLFLDFHSMEIIKGGADEDSASDLSDSERVAIPPSPFTPPDLNLRAEEIDPVSFSLHPEPSQAESGHCYPDFLPPPFNSWDLRDMAVVLNTECRTEALPRATGLLGKYIDRLLQLEWLQVQTVQGEKARAAKAKLPGAAGGLKSPGRGKLLTSSLSKPLPSPEGISKPGPSRKKGFRHEEAHPSYYAFETLPNSGDGPGRPRLCSQKQAPEPRMEKKKKSSKGPKPQLRAPPCVEGNPAMEANGNIRIPKQSPVLLDPVGSYRASRTQAHVDLKKKGSANNCGCAPSSGEKKLKTNGAKQSTYKLK", "length": 445 }, "evidence": [ { "id": "A0AAA9S8L1", "url": "https://omabrowser.org/oma/group/A0AAA9S8L1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RJ11-1", "protein_name": "Family with sequence similarity 217 member B", "gene_name": "FAM217B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNAGPSWTKAQHAKNPARRRQSKPQGPPGSSQLKSSPGGGGPQRTEGKRKEGTSSGGNPERALGASGNRSFLDFPSLEIIKGDADDSDSASDLSDSERVPVLPSPLTPPDLRLRAEEIDPAHEHLRPGQGPAKPDLRYPDFLPAPFNSWDLRDMAVLLHSERRAEAGPRAGGLLGRYIDRLVQLEWLQIQTIQCEKGKGPKARPPTAPGASGALKSPGRSKLMASALSRPPQEGPRKSGPSRKKDLPLEEVQPSCRAFEAPPAPLDALSSGRLCSQKQSLNMRPEEKRKKPSKSSQLQPWDLSCADRDSSGPKLESKGNLRVPRPSAGILDSADSYKACRAQAHALLKKKGNANHCARAPVSSEKKLKTNGVKCINSNKN", "length": 380 }, "evidence": [ { "id": "A0AAA9S8L1", "url": "https://omabrowser.org/oma/group/A0AAA9S8L1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9NTX9-1", "protein_name": "Protein FAM217B", "gene_name": "FAM217B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNAGPSWNKVQHSKNSSGKRQSKSQVPHASSQPRSSLTAVTQPTEEKLKESISPEARRKRNPLGSRCQGASGNKLFLDFQSMKIIKENADEDSASDLSDSERIPIPPSPLTPPDLNLRAEEIDPVYFDLHPGQGHTKPEYYYPNFLPSPFSSWDLRDMALLLNAENKTEAVPRVGGLLGKYIDRLIQLEWLQVQTVQCEKAKGGKARPPTAPGTSGALKSPGRSKLIASALSKPLPHQEGASKSGPSRKKAFHHEEIHPSHYAFETSPRPIDVLGGTRFCSQRQTLEMRTEEKKKKSSKSTKLQRWDLSGSGSSSKVETSGHIRVPKQAAVILDSADSCKASKTQAHAHPRKKGKAESCGHATVSSEKKLKTNGVKQNTYKLK", "length": 383 }, "evidence": [ { "id": "A0AAA9S8L1", "url": "https://omabrowser.org/oma/group/A0AAA9S8L1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 112, 137 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 }, { "start_pos": 352, "end_pos": 354 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8L5-1", "uniprot_ac": "A0AAA9S8L5", "uniprot_id": "A0AAA9S8L5_BOVIN", "mass": { "chemical_mass": 39558.0, "monoisotopic_mass": 39558.0 }, "refseq": {}, "gene_names": [ { "name": "DMRTC2", "type": "recommended", "evidence": [ { "id": "A0AAA9S8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ] } ], "protein_names": [ { "name": "DMRT like family C2", "type": "synonym", "evidence": [ { "id": "A0AAA9S8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DMRTC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5", "locus": { "chromosome": "18", "start_pos": 51367681, "end_pos": 51373336, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019273", "url": "https://www.ensembl.org/id/ENSBTAG00000019273" } ] } } ], "crossref": [ { "id": "A0AAA9S8L5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8L5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019273", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019273", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PLPWTPM", "url": "https://omabrowser.org/oma/group/PLPWTPM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKG3", "url": "https://www.orthodb.org/?gene=F1MKG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12322", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12322", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12322:SF124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12322:SF124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00751", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00751", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKG3", "url": "https://www.uniprot.org/uniprotkb/F1MKG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKG3-1", "url": "https://www.uniprot.org/uniprotkb/F1MKG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSMDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS", "length": 373, "header": "tr|A0AAA9S8L5-1|A0AAA9S8L5_BOVIN Isoform 1 of DMRT like family C2 OS=Bos taurus OX=9913 GN=DMRTC2 PE=3 SV=1 CANONICAL=A0AAA9S8L5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5/entry#A0AAA9S8L5-1", "sequence": { "sequence": "MGSMDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS", "length": 373, "header": "tr|A0AAA9S8L5-1|A0AAA9S8L5_BOVIN Isoform 1 of DMRT like family C2 OS=Bos taurus OX=9913 GN=DMRTC2 PE=3 SV=1 CANONICAL=A0AAA9S8L5-1" }, "locus": { "chromosome": "18", "start_pos": 51372681, "end_pos": 51368127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119062.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119062.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081610.1" } ] } }, { "isoform_ac": "A0AAA9SZD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5/entry#A0AAA9SZD4-1", "sequence": { "sequence": "MRDSTRRAIGWIDSPARGEADRRSMDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS", "length": 394, "header": "tr|A0AAA9SZD4-1|A0AAA9SZD4_BOVIN Computationally mapped isoform of DMRT like family C2 OS=Bos taurus OX=9913 GN=DMRTC2 PE=3 SV=1 CANONICAL=A0AAA9S8L5-1" }, "locus": { "chromosome": "18", "start_pos": 51373187, "end_pos": 51368127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109662.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109662.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090781.1" } ] } }, { "isoform_ac": "F1MKG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5/entry#F1MKG3-1", "sequence": { "sequence": "MDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS", "length": 370, "header": "tr|F1MKG3-1|F1MKG3_BOVIN Computationally mapped isoform of DMRT like family C2 OS=Bos taurus OX=9913 GN=DMRTC2 PE=3 SV=1 CANONICAL=A0AAA9S8L5-1" }, "locus": { "chromosome": "18", "start_pos": 51371886, "end_pos": 51368127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025660.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025660.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025660.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025660.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8CGW9-1", "protein_name": "Doublesex- and mab-3-related transcription factor C2", "gene_name": "Dmrtc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPSETAALHHCSADSSPADEARVPQSTELIPRRPVSRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLAQGLMKGATPLKAPLRVKKGAIRPGIPSGKENIAPQPQSPHGAVPLVLTPPGKENYGPLLLSRPPEALPLPWTPVPPGPWGPGHWLPPGLSMPPPVVCRLLCQEPAVPLHPFPGFDPGTSLRLPTHGTLPTCPGSRSVLTAPLSGEPQGPPNLPHTCSTLILQSCGTPDSLLLQPQAPGASCLAWTSGPSERQLQREAAEALVGLKDSSQAPRLTPSVPPNPAWISLLHPCGPPAPPGGRGFQPVGPPLRPSPGSSVSLHIGRLGSISLLS", "length": 370 }, "evidence": [ { "id": "A0AAA9S8L5", "url": "https://omabrowser.org/oma/group/A0AAA9S8L5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IXT2-1", "protein_name": "Doublesex- and mab-3-related transcription factor C2", "gene_name": "DMRTC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPSDMPAGYHCPLDSAPWDETRDPQSTELIPRRAISRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNHFRKGTTQPQVPSGKENIAPQPQTPHGAVLLAPTPPGKNSCGPLLLSHPPEASPLSWTPVPPGPWVPGHWLPPGFSMPPPVVCRLLYQEPAVSLPPFPGFDPGTSLQLPTHGPFTTCPGSHPVLTAPLSGEPQGPPSQPRTHSTLILQPCGTPDPLQLQPQASGASCLARTSGPSEWQLQQEAAEALVGLKDSSQAPRVTPSVPPNPAWISLLHPCGPPAPAGGRGFQPVGPCLRPSPAPSVALHIGRLGSISLLS", "length": 367 }, "evidence": [ { "id": "A0AAA9S8L5", "url": "https://omabrowser.org/oma/group/A0AAA9S8L5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" }, { "name": "XY body", "id": "GO:0001741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" }, { "name": "adult locomotory behavior", "id": "GO:0008344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008344", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L5" }, { "id": "PS50809", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50809" }, { "id": "PRU00070", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00070" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DM", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 92, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8N5-1", "uniprot_ac": "A0AAA9S8N5", "uniprot_id": "A0AAA9S8N5_BOVIN", "mass": { "chemical_mass": 30681.0, "monoisotopic_mass": 30681.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Mucin-21", "type": "recommended", "evidence": [ { "id": "A0AAA9S8N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8N5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5", "locus": {} } ], "crossref": [ { "id": "A0AAA9S8N5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8N5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF05647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8N5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSEESSTTSDTGSSVTSGESSTTSDTGSSMTSGESSTTSDTGSSVTSGESSTTSDTGSSVTSGGASTTSSTGSSGTSGGASTTSSTGSSGTSGGASTTSDTGSSGTSGGASTTSDTGSSGTSGGASTTSDTGSSGTSGRTSTTSSTGSSGTSGGASTTSDSGSSGTSGRASTTSDTGSSTASSGTSTASKTGSSATTGGSDTSFPTGTHTTSNKSSTSAGTPVEDVKPSGSLKPWEIFLITLVSVVVVVGFFAGLFFCVRNSLSLRNVLDTAVYRPHGPNLGRGPGGNHGAHHRPGRSPARSWNRPISSVTMEMRESHSGF", "length": 322, "header": "tr|A0AAA9S8N5-1|A0AAA9S8N5_BOVIN Isoform 1 of Mucin-21 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S8N5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5/entry#A0AAA9S8N5-1", "sequence": { "sequence": "MTSEESSTTSDTGSSVTSGESSTTSDTGSSMTSGESSTTSDTGSSVTSGESSTTSDTGSSVTSGGASTTSSTGSSGTSGGASTTSSTGSSGTSGGASTTSDTGSSGTSGGASTTSDTGSSGTSGGASTTSDTGSSGTSGRTSTTSSTGSSGTSGGASTTSDSGSSGTSGRASTTSDTGSSTASSGTSTASKTGSSATTGGSDTSFPTGTHTTSNKSSTSAGTPVEDVKPSGSLKPWEIFLITLVSVVVVVGFFAGLFFCVRNSLSLRNVLDTAVYRPHGPNLGRGPGGNHGAHHRPGRSPARSWNRPISSVTMEMRESHSGF", "length": 322, "header": "tr|A0AAA9S8N5-1|A0AAA9S8N5_BOVIN Isoform 1 of Mucin-21 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S8N5-1" }, "locus": { "chromosome": "23", "start_pos": 28106677, "end_pos": 28105355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092870.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092870.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079714.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5" }, { "id": "PF14654", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14654" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mucin catalytic TM and cytoplasmic tail", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 308, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N5" }, { "id": "PF05647", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05647" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tandem-repeating region of mucin epiglycanin-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 91, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8N6-1", "uniprot_ac": "A0AAA9S8N6", "uniprot_id": "A0AAA9S8N6_BOVIN", "mass": { "chemical_mass": 52360.0, "monoisotopic_mass": 52360.0 }, "refseq": {}, "gene_names": [ { "name": "SMTNL1", "type": "recommended", "evidence": [ { "id": "A0AAA9S8N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6" } ] } ], "protein_names": [ { "name": "Smoothelin like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S8N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMTNL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6", "locus": { "chromosome": "15", "start_pos": 80814028, "end_pos": 80791129, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027524", "url": "https://www.ensembl.org/id/ENSBTAG00000027524" } ] } } ], "crossref": [ { "id": "A0AAA9S8N6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8N6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027524", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027524", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21260", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21260", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614015", "url": "https://www.ncbi.nlm.nih.gov/gene/614015", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614015", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614015", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EWPESPS", "url": "https://omabrowser.org/oma/group/EWPESPS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPV6", "url": "https://www.orthodb.org/?gene=E1BPV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPV6", "url": "https://www.uniprot.org/uniprotkb/E1BPV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPV6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGCVCLLFPEMEQKAGKSSEDGATVPPAAEAPEPAGSGGSAEEETAGPAESAARAGPATAGQQERAPAEDAVSAECQADGLGEVKAESQGEVELQQEDPGQGETAAAHGKTDRKDQTDSEPAGAEGDRETASASEEQSADEKEARLGSRETVDASREVQAEPKQASGAQEAEAGGGEAEGPQEEGGKTEEPQAEAREEAGAPAAQPDSPKAAVEDEAKPEPQEEEEPGSPDEEQDQGAGAEAEDGAGGPPSSPEGWPESPTEEGGSASPEGLSPDTAASEELGPSASDSSPSDVPQSPTEPPPSEEKKKEKAPERRVSAPTRPRGPRAQNRKAIVDKFGGAAAGPTALFRNTKAAGAAVGGVRNMLLEWCRAMTRSYEHVDIQNFSSSWGSGMAFCALIHKFFPDAFDYAALDPAQRRHNFTLAFSTAECFSDAGNWRRTEQWVKPTKSPLACDSYSILYYFTFRPCPVACGILVPQTGIKPSLLALEAESLNHWPTSKVP", "length": 502, "header": "tr|A0AAA9S8N6-1|A0AAA9S8N6_BOVIN Isoform 1 of Smoothelin like 1 OS=Bos taurus OX=9913 GN=SMTNL1 PE=4 SV=1 CANONICAL=A0AAA9S8N6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6/entry#A0AAA9S8N6-1", "sequence": { "sequence": "MTGCVCLLFPEMEQKAGKSSEDGATVPPAAEAPEPAGSGGSAEEETAGPAESAARAGPATAGQQERAPAEDAVSAECQADGLGEVKAESQGEVELQQEDPGQGETAAAHGKTDRKDQTDSEPAGAEGDRETASASEEQSADEKEARLGSRETVDASREVQAEPKQASGAQEAEAGGGEAEGPQEEGGKTEEPQAEAREEAGAPAAQPDSPKAAVEDEAKPEPQEEEEPGSPDEEQDQGAGAEAEDGAGGPPSSPEGWPESPTEEGGSASPEGLSPDTAASEELGPSASDSSPSDVPQSPTEPPPSEEKKKEKAPERRVSAPTRPRGPRAQNRKAIVDKFGGAAAGPTALFRNTKAAGAAVGGVRNMLLEWCRAMTRSYEHVDIQNFSSSWGSGMAFCALIHKFFPDAFDYAALDPAQRRHNFTLAFSTAECFSDAGNWRRTEQWVKPTKSPLACDSYSILYYFTFRPCPVACGILVPQTGIKPSLLALEAESLNHWPTSKVP", "length": 502, "header": "tr|A0AAA9S8N6-1|A0AAA9S8N6_BOVIN Isoform 1 of Smoothelin like 1 OS=Bos taurus OX=9913 GN=SMTNL1 PE=4 SV=1 CANONICAL=A0AAA9S8N6-1" }, "locus": { "chromosome": "15", "start_pos": 80809391, "end_pos": 80805386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131915.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131915.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081635.1" } ] } }, { "isoform_ac": "A0AAA9SLS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6/entry#A0AAA9SLS6-1", "sequence": { "sequence": "MEQKAGKSSEDGATVPPAAEAPEPAGSGGSAEEETAGPAESAARAGPATAGQQERAPAEDAVSAECQADGLGEVKAESQGEVELQQEDPGQGETAAAHGKTDRKDQTDSEPAGAEGDRETASASEEQSADEKEARLGSRETVDASREVQAEPKQASGAQEAEAGGGEAEGPQEEGGKTEEPQAEAREEAGAPAAQPDSPKAAVEDEAKPEPQEEEEPGSPDEEQDQGAGAEAEDGAGGPPSSPEGWPESPTEEGGSASPEGLSPDTAASEELGPSASDSSPSDVPQSPTEPPPSEEKKKEKAPERRVSAPTRPRGPRAQNRKAIVDKFGGAAAGPTALFRNTKAAGAAVGGVRNMLLEWCRAMTRSYEHVDIQNFSSSWGSGMAFCALIHKFFPDAFDYAALDPAQRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK", "length": 466, "header": "tr|A0AAA9SLS6-1|A0AAA9SLS6_BOVIN Computationally mapped isoform of Smoothelin like 1 OS=Bos taurus OX=9913 GN=SMTNL1 PE=3 SV=1 CANONICAL=A0AAA9S8N6-1" }, "locus": { "chromosome": "15", "start_pos": 80813918, "end_pos": 80805419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129472.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129472.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086209.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086209.1" } ] } }, { "isoform_ac": "A0AAA9TWZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6/entry#A0AAA9TWZ2-1", "sequence": { "sequence": "MTGCVCLLFPEMEQKAGKSSEDGATVPPAAEAPEPAGSGGSAEEETAGPAESAARAGPATAGQQERAPAEDAVSAECQADGLGEVKAESQGEVELQQEDPGQGETAAAHGKTDRKDQTDSEPAGAEGDRETASASEEQSADEKEARLGSRETVDASREVQAEPKQASGAQEAEAGGGEAEGPQEEGGKTEEPQAEAREEAGAPAAQPDSPKAAVEDEAKPEPQEEEVTERVEPGSPDEEQDQGAGAEAEDGAGGPPSSPEGWPESPTEEGGSASPEGLSPDTAASEELGPSASDSSPSDVPQSPTEPPPSEEKKKEKAPERRVSAPTRPRGPRAQNRKAIVDKFGGAAAGPTALFRNTKAAGAAVGGVRNMLLEWCRAMTRSYEHVDIQNFSSSWGSGMAFCALIHKFFPDAFDYAALDPAQRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK", "length": 482, "header": "tr|A0AAA9TWZ2-1|A0AAA9TWZ2_BOVIN Computationally mapped isoform of Smoothelin like 1 OS=Bos taurus OX=9913 GN=SMTNL1 PE=3 SV=1 CANONICAL=A0AAA9S8N6-1" }, "locus": { "chromosome": "15", "start_pos": 80813918, "end_pos": 80805386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115352.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115352.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101986.1" } ] } }, { "isoform_ac": "E1BPV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6/entry#E1BPV6-1", "sequence": { "sequence": "MEQKAGKSSEDGATVPPAAEAPEPAGSGGSAEEETAGPAESAARAGPATAGQQERAPAEDAVSAECQADGLGEVKAESQGEVELQQEDPGQGETAAAHGKTDRKDQTDSEPAGAEGDRETASASEEQSADEKEARLGSRETVDASREVQAEPKQASGAQEAEAGGGEAEGPQEEGGKTEEPQAEAREEAGAPAAQPDSPKAAVEDEAKPEPQEEEVTERVEPGSPDEEQDQGAGAEAEDGAGGPPSSPEGWPESPTEEGGSASPEGLSPDTAASEELGPSASSDSSPSDVPQSPTEPPPSEEKKKEKAPERRVSAPTRPRGPRAQNRKAIVDKFGGAAAGPTALFRNTKAAGAAVGGVRNMLLEWCRAMTRSYEHVDIQNFSSSWGSGMAFCALIHKFFPDAFDYAALDPAQRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK", "length": 472, "header": "tr|E1BPV6-1|A0AAA9S8N6_BOVIN Computationally mapped isoform of Smoothelin like 1 OS=Bos taurus OX=9913 GN=SMTNL1 PE=4 SV=4 CANONICAL=A0AAA9S8N6-1" }, "locus": { "chromosome": "15", "start_pos": 80813918, "end_pos": 80805419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043836.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043836.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041378.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041378.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 347, "start_aa": "Thr", "end_pos": 347, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr347", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614015", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614015", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZP11-1", "protein_name": "Smoothelin-like 1", "gene_name": "Smtnl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQTEGNPSEDGTTVSPTAGNLATPGSQGTAEEVAEGTVGTNDKEEPPDGAEHLCKAASEGGISGGCQVEASILEELKTDSQGEARGKEEAKADLAEEKGGKEDTTVSSQEDTGKKEETKPEPSEVTEKEEAVLPLEKQKVDEKETNLESKEKSDVNDKAEPESKEDAGAEVTVKEAETESQKKADVKDQAEPQLQEVDGKEARSDTKELVEPGSPTEEQEEQGKENESEERAAVIPSSPEDWPESPTDEGTSLSPDGLGPESTASGETSASASESSPSEVPESPTEPLPSEKKKERAPERRVSAPTRPRGPRAQNRKAIMDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPTKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK", "length": 462 }, "evidence": [ { "id": "A0AAA9S8N6", "url": "https://omabrowser.org/oma/group/A0AAA9S8N6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A8MU46-1", "protein_name": "Smoothelin-like protein 1", "gene_name": "SMTNL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK", "length": 494 }, "evidence": [ { "id": "A0AAA9S8N6", "url": "https://omabrowser.org/oma/group/A0AAA9S8N6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99LM3-1", "protein_name": "Smoothelin-like protein 1", "gene_name": "Smtnl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQTEGNSSEDGTTVSPTAGNLETPGSQGIAEEVAEGTVGTSDKEGPSDWAEHLCKAASKSGESGGSPGEASILDELKTDLQGEARGKDEAQGDLAEEKVGKEDTTAASQEDTGKKEETKPEPNEVREKEEAMLASEKQKVDEKETNLESKEKSDVNDKAKPEPKEDAGAEVTVNEAETESQEEADVKDQAKPELPEVDGKETGSDTKELVEPESPTEEQEQGKENESEERAAVIPSSPEEWPESPTDEGPSLSPDGLAPESTGETSPSASESSPSEVPGSPTEPQPSEKKKDRAPERRVSAPSRPRGPRAQNRKAIMDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCALIHKFFPEAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK", "length": 459 }, "evidence": [ { "id": "A0AAA9S8N6", "url": "https://omabrowser.org/oma/group/A0AAA9S8N6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "contractile muscle fiber", "id": "GO:0043292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043292", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N6" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 361, "end_pos": 463, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 347 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 385, "end_pos": 387 }, { "start_pos": 421, "end_pos": 423 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8P6-1", "uniprot_ac": "A0AAA9S8P6", "uniprot_id": "A0AAA9S8P6_BOVIN", "mass": { "chemical_mass": 6720.0, "monoisotopic_mass": 6720.0 }, "refseq": { "ac": "XP_024837767", "name": "cortexin domain-containing 1 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837767" }, "gene_names": [ { "name": "CTXND1", "type": "recommended", "evidence": [ { "id": "A0AAA9S8P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6" } ] }, { "name": "CTXND1", "type": "synonym", "evidence": [ { "id": "XP_024837767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837767" } ] } ], "protein_names": [ { "name": "Cortexin domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S8P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6/entry#names_and_taxonomy" } ] }, { "name": "cortexin domain-containing 1 protein", "type": "synonym", "evidence": [ { "id": "XP_024837767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837767" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTXND1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6", "locus": { "chromosome": "21", "start_pos": 26155447, "end_pos": 26155626, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069252", "url": "https://www.ensembl.org/id/ENSBTAG00000069252" } ] } } ], "crossref": [ { "id": "A0AAA9S8P6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "107131603", "url": "https://www.ncbi.nlm.nih.gov/gene/107131603", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:107131603", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:107131603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR16736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16736:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16736:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024837767", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837767", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDPTPEPVYVDVDKGLTLACFVFLCLFLVVMIIRCAKVIMDPYSAIPTSTWEEQHLDD", "length": 59, "header": "tr|A0AAA9S8P6-1|A0AAA9S8P6_BOVIN Isoform 1 of Cortexin domain containing 1 OS=Bos taurus OX=9913 GN=CTXND1 PE=4 SV=1 CANONICAL=A0AAA9S8P6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6/entry#A0AAA9S8P6-1", "sequence": { "sequence": "MEDPTPEPVYVDVDKGLTLACFVFLCLFLVVMIIRCAKVIMDPYSAIPTSTWEEQHLDD", "length": 59, "header": "tr|A0AAA9S8P6-1|A0AAA9S8P6_BOVIN Isoform 1 of Cortexin domain containing 1 OS=Bos taurus OX=9913 GN=CTXND1 PE=4 SV=1 CANONICAL=A0AAA9S8P6-1" }, "locus": { "chromosome": "21", "start_pos": 26155626, "end_pos": 26155450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109261.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109261.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081645.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081645.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:107131603", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:107131603", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8P8-1", "uniprot_ac": "A0AAA9S8P8", "uniprot_id": "A0AAA9S8P8_BOVIN", "mass": { "chemical_mass": 8029.0, "monoisotopic_mass": 8029.0 }, "refseq": { "ac": "XP_059733216", "name": "large ribosomal subunit protein eL38-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733216" }, "gene_names": [ { "name": "LOC107131456", "type": "recommended", "evidence": [ { "id": "A0AAA9S8P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8" } ] }, { "name": "LOC107131456", "type": "synonym", "evidence": [ { "id": "XP_059733216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733216" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL38", "type": "recommended", "evidence": [ { "id": "A0AAA9S8P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L38", "type": "synonym", "evidence": [ { "id": "A0AAA9S8P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL38-like", "type": "synonym", "evidence": [ { "id": "XP_059733216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733216" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC107131456", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8", "locus": {} } ], "crossref": [ { "id": "A0AAA9S8P8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8P8", "database": "AlphaFoldDB", "categories": [] }, { "id": "107131456", "url": "https://www.ncbi.nlm.nih.gov/gene/107131456", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:107131456", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:107131456", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10965", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10965", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10965:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10965:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059733216", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733216", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCKTEEIEDNRLTAGRKDAKSVKIKKNKDDVKFSVRCSRYLYTLVITDNKKAETLKQTEPPGSAVKERK", "length": 70, "header": "tr|A0AAA9S8P8-1|A0AAA9S8P8_BOVIN Isoform 1 of Large ribosomal subunit protein eL38 OS=Bos taurus OX=9913 GN=LOC107131456 PE=3 SV=1 CANONICAL=A0AAA9S8P8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8/entry#A0AAA9S8P8-1", "sequence": { "sequence": "MPCKTEEIEDNRLTAGRKDAKSVKIKKNKDDVKFSVRCSRYLYTLVITDNKKAETLKQTEPPGSAVKERK", "length": 70, "header": "tr|A0AAA9S8P8-1|A0AAA9S8P8_BOVIN Isoform 1 of Large ribosomal subunit protein eL38 OS=Bos taurus OX=9913 GN=LOC107131456 PE=3 SV=1 CANONICAL=A0AAA9S8P8-1" }, "locus": { "chromosome": "18", "start_pos": 60153118, "end_pos": 60152909, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135143.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135143.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079732.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:107131456", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:107131456", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8P8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8Q9-1", "uniprot_ac": "A0AAA9S8Q9", "uniprot_id": "A0AAA9S8Q9_BOVIN", "mass": { "chemical_mass": 27915.0, "monoisotopic_mass": 27915.0 }, "refseq": { "ac": "XP_002697763", "name": "proteasome subunit alpha-type 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697763" }, "gene_names": [ { "name": "PSMA8", "type": "recommended", "evidence": [ { "id": "A0AAA9S8Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ] }, { "name": "PSMA8", "type": "synonym", "evidence": [ { "id": "XP_002697763", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697763" } ] } ], "protein_names": [ { "name": "Proteasome subunit alpha type", "type": "recommended", "evidence": [ { "id": "A0AAA9S8Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9/entry#names_and_taxonomy" } ] }, { "name": "proteasome subunit alpha-type 8", "type": "synonym", "evidence": [ { "id": "XP_002697763", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697763" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9", "locus": { "chromosome": "24", "start_pos": 30635286, "end_pos": 30668998, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017698", "url": "https://www.ensembl.org/id/ENSBTAG00000017698" } ] } } ], "crossref": [ { "id": "A0AAA9S8Q9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8Q9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017698", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017698", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03755", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03755", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614703", "url": "https://www.ncbi.nlm.nih.gov/gene/614703", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614703", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614703", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AGTHSEW", "url": "https://omabrowser.org/oma/group/AGTHSEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD83", "url": "https://www.orthodb.org/?gene=E1BD83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10584", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10584", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697763", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697763", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD83", "url": "https://www.uniprot.org/uniprotkb/E1BD83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD83-1", "url": "https://www.uniprot.org/uniprotkb/E1BD83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINKARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIANDNEAIKLAIRALLEVVQSGGKNIELAIIRRNQPLKMFSAKEIELQVNEIEKEKEEAEKKKSKKTT", "length": 250, "header": "tr|A0AAA9S8Q9-1|A0AAA9S8Q9_BOVIN Isoform 1 of Proteasome subunit alpha type OS=Bos taurus OX=9913 GN=PSMA8 PE=3 SV=1 CANONICAL=A0AAA9S8Q9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9/entry#A0AAA9S8Q9-1", "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINKARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIANDNEAIKLAIRALLEVVQSGGKNIELAIIRRNQPLKMFSAKEIELQVNEIEKEKEEAEKKKSKKTT", "length": 250, "header": "tr|A0AAA9S8Q9-1|A0AAA9S8Q9_BOVIN Isoform 1 of Proteasome subunit alpha type OS=Bos taurus OX=9913 GN=PSMA8 PE=3 SV=1 CANONICAL=A0AAA9S8Q9-1" }, "locus": { "chromosome": "24", "start_pos": 30657276, "end_pos": 30636290, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126220.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126220.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078545.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078545.1" } ] } }, { "isoform_ac": "E1BD83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9/entry#E1BD83-1", "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINKARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIANDNEAIKLAIRALLEVVQSGGKNIELAIIRRNQPLKDSGTAVPKPQGHRTTDSRVSSPAPRHTYMFSAKEIELQVNEIEKEKEEAEKKKSKKTT", "length": 278, "header": "tr|E1BD83-1|E1BD83_BOVIN Computationally mapped isoform of Proteasome subunit alpha type OS=Bos taurus OX=9913 GN=PSMA8 PE=3 SV=4 CANONICAL=A0AAA9S8Q9-1" }, "locus": { "chromosome": "24", "start_pos": 30657276, "end_pos": 30636290, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023541.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023541.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023541.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023541.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614703", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614703", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M6I7-1", "protein_name": "Proteasome subunit alpha type", "gene_name": "Psma8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVISRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAISNDNEAIKLAIKALLEVVQSGGKNIELAIIRRDQPLKMFSAKEIELEVTEIEREKDEAEKKKSKKST", "length": 250 }, "evidence": [ { "id": "A0AAA9S8Q9", "url": "https://omabrowser.org/oma/group/A0AAA9S8Q9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SBA5-1", "protein_name": "Proteasome subunit alpha type", "gene_name": "PSMA8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVAIRGTDIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIANDNEAIKLAIRALLEVVQSGGKNIELAIIRRNQPLKMFSAKEIELQVNEIEKEKEEAEKKKSKKTA", "length": 250 }, "evidence": [ { "id": "A0AAA9S8Q9", "url": "https://omabrowser.org/oma/group/A0AAA9S8Q9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P30186-1", "protein_name": "Proteasome subunit alpha type-7-A", "gene_name": "PAD1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARYDRAITVFSPDGHLFQVEYALEAVRKGNAAVGVRGTDTVVLAVEKKSTPKLQDSRSARKIVSLDNHIALACAGLKADARVLINKARIECQSHRLTLEDPVTVEYITRYIAGLQQKYTQSGGVRPFGLSTLIVGFDPYTRIPALYQTDPSGTFSAWKANATGRNSNSIREFLEKNYKESAGQETVKLAIRALLEVVESGGKNIEVAVMTREEGVLKQLEEEEIDIIVAEIEAEKAAAEAAKKGPAKET", "length": 250 }, "evidence": [ { "id": "A0AAA9S8Q9", "url": "https://omabrowser.org/oma/group/A0AAA9S8Q9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8TAA3-1", "protein_name": "Proteasome subunit alpha-type 8", "gene_name": "PSMA8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKKSV", "length": 256 }, "evidence": [ { "id": "A0AAA9S8Q9", "url": "https://omabrowser.org/oma/group/A0AAA9S8Q9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CWH6-1", "protein_name": "Proteasome subunit alpha type-8", "gene_name": "Psma8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVISRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAISNDKEAIKLAIKALLEVVQSGGKNIELAIIRRDQPLKMFSAKEIELEVSEIEREKDEAEKTKSKKST", "length": 250 }, "evidence": [ { "id": "A0AAA9S8Q9", "url": "https://omabrowser.org/oma/group/A0AAA9S8Q9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" }, { "name": "proteasome core complex, alpha-subunit complex", "id": "GO:0019773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019773", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" }, { "name": "spermatoproteasome complex", "id": "GO:1990111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990111", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" }, { "name": "regulation of meiosis I", "id": "GO:0060631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Q9" }, { "id": "PS00388", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00388" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Proteasome alpha-type subunits", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 27, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8U8-1", "uniprot_ac": "A0AAA9S8U8", "uniprot_id": "A0AAA9S8U8_BOVIN", "mass": { "chemical_mass": 21128.0, "monoisotopic_mass": 21128.0 }, "refseq": { "ac": "XP_002688283", "name": "COMM domain-containing protein 8 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688283" }, "gene_names": [ { "name": "COMMD8", "type": "recommended", "evidence": [ { "id": "A0AAA9S8U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ] }, { "name": "COMMD8", "type": "synonym", "evidence": [ { "id": "XP_002688283", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688283" } ] } ], "protein_names": [ { "name": "COMM domain containing 8", "type": "synonym", "evidence": [ { "id": "A0AAA9S8U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8/entry#names_and_taxonomy" } ] }, { "name": "COMM domain-containing protein 8 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002688283", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688283" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COMMD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8", "locus": { "chromosome": "6", "start_pos": 66095491, "end_pos": 66110973, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001348", "url": "https://www.ensembl.org/id/ENSBTAG00000001348" } ] } } ], "crossref": [ { "id": "A0AAA9S8U8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8U8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001348", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001348", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04756", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04756", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507292", "url": "https://www.ncbi.nlm.nih.gov/gene/507292", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507292", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507292", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KLCHRVV", "url": "https://omabrowser.org/oma/group/KLCHRVV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N7D3", "url": "https://www.orthodb.org/?gene=F1N7D3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16231:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16231:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22838", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22838", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002688283", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688283", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7D3", "url": "https://www.uniprot.org/uniprotkb/F1N7D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7D3-1", "url": "https://www.uniprot.org/uniprotkb/F1N7D3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPEEGTPLWRLQKLPAERGLQLLHKIIDGICGRTYPLYQDYHSVWDSTEWMHVLEDITTFFKAVVGKNLSDEEISQQLNQLNSSHQEAIMKCLKSRKDEIKKTLLEEIVDISSARLQDFDWQIKLALSSDKIASLQMPLLNLYLDVKENGEVKPYSVEMSKEELQKLINSLEAANKVVLQLK", "length": 183, "header": "tr|A0AAA9S8U8-1|A0AAA9S8U8_BOVIN Isoform 1 of COMM domain containing 8 OS=Bos taurus OX=9913 GN=COMMD8 PE=4 SV=1 CANONICAL=A0AAA9S8U8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8/entry#A0AAA9S8U8-1", "sequence": { "sequence": "MEPEEGTPLWRLQKLPAERGLQLLHKIIDGICGRTYPLYQDYHSVWDSTEWMHVLEDITTFFKAVVGKNLSDEEISQQLNQLNSSHQEAIMKCLKSRKDEIKKTLLEEIVDISSARLQDFDWQIKLALSSDKIASLQMPLLNLYLDVKENGEVKPYSVEMSKEELQKLINSLEAANKVVLQLK", "length": 183, "header": "tr|A0AAA9S8U8-1|A0AAA9S8U8_BOVIN Isoform 1 of COMM domain containing 8 OS=Bos taurus OX=9913 GN=COMMD8 PE=4 SV=1 CANONICAL=A0AAA9S8U8-1" }, "locus": { "chromosome": "6", "start_pos": 66109757, "end_pos": 66096692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132569.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132569.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081708.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081708.1" } ] } }, { "isoform_ac": "F1N7D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8/entry#F1N7D3-1", "sequence": { "sequence": "MEPEEGTPLWRLQKLPAERGLQHSPCTRNTGARCWEYRGDLERQAVILCGWQKKLLLHKIIDGICGRTYPLYQDYHSVWDSTEWMHVLEDITTFFKAVVGKNLSDEEISQQLNQLNSSHQEAIMKCLKSRKDEIKKTLLEEIVDISSARLQDFDWQIKLALSSDKIASLQMPLLNLYLDVKENGEVKPYSVEMSKEELQKLINSLEAANKVVLQLK", "length": 216, "header": "tr|F1N7D3-1|F1N7D3_BOVIN Computationally mapped isoform of COMM domain containing 8 OS=Bos taurus OX=9913 GN=COMMD8 PE=4 SV=2 CANONICAL=A0AAA9S8U8-1" }, "locus": { "chromosome": "6", "start_pos": 66109757, "end_pos": 66096692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039626.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039626.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039416.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039416.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507292", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507292", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480XDE4-1", "protein_name": "COMM domain containing 8", "gene_name": "COMMD8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPEEGTPLWRLQKLPAELGPQLLHKIIDGFCGRTYPLYKDYQSVWDSTEWMHVLEDITEFFKAVVGKNLTDEEISQQLNQLNSSHQEAIMKCLKSRKDEIKQALLEEIVGISSAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKENGEVKPYSVEMSKEELQNLINSLEAANKVVLQLK", "length": 183 }, "evidence": [ { "id": "A0AAA9S8U8", "url": "https://omabrowser.org/oma/group/A0AAA9S8U8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7EZP4-1", "protein_name": "COMM domain-containing protein 8", "gene_name": "Commd8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEAEDGTPPLWRLQKLPPEQGPPLLHKIIDGMCGRAYPAYHDYHSVWDLTEWKHVLEDVTMFFKAVVGKNFSDEETLQQLNQLNSCHQEAVMKCLKSRKNEIKQALLGEIVDISCAQLKDFDWQLKLALSSDKIATLQMPLLNLHLDVKENGEVKPYSVEMSKEELQSLISSLEAANKVVLQLK", "length": 184 }, "evidence": [ { "id": "A0AAA9S8U8", "url": "https://omabrowser.org/oma/group/A0AAA9S8U8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B0K015-1", "protein_name": "COMM domain containing 8", "gene_name": "Commd8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRRGRDDYSWDPGDRMAAKEIYAGLGMAQAWLLHKIIDGICGRAYPAHQDYHSVWNSTEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCHQEAVMKCLKSRKNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDGEVKPYSVEMSKEELQSLISSLEAANKVVLQLK", "length": 193 }, "evidence": [ { "id": "A0AAA9S8U8", "url": "https://omabrowser.org/oma/group/A0AAA9S8U8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CZG3-1", "protein_name": "COMM domain-containing protein 8", "gene_name": "Commd8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPEEGTPLWRLQKLPPEQGAGLLHKIIDGFCGRAYPAHQDYHSVWNSAEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCHQEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPYTVEMSKEELQSLISSLEAANKVVLQLK", "length": 183 }, "evidence": [ { "id": "A0AAA9S8U8", "url": "https://omabrowser.org/oma/group/A0AAA9S8U8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX08-1", "protein_name": "COMM domain-containing protein 8", "gene_name": "COMMD8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK", "length": 183 }, "evidence": [ { "id": "A0AAA9S8U8", "url": "https://omabrowser.org/oma/group/A0AAA9S8U8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GIV5-1", "protein_name": "COMM domain containing 8", "gene_name": "COMMD8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLQLLEKLPPGRALEFLHNIVDGICGRGYPRYQDYSGVWSLAEWMEVLEETRTYFKTAVGKNVTDEEAVQQMNELNANYQEAIIKCLKARKEEIRNALVETVNAISSAQLQDFDWQLKLALSSDKISMLQMPLLNLDLDVRENGEIKPISIEMNKEELQNLINALEAANKIVLQLK", "length": 176 }, "evidence": [ { "id": "A0AAA9S8U8", "url": "https://omabrowser.org/oma/group/A0AAA9S8U8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "NF-kappaB binding", "id": "GO:0051059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U8" }, { "id": "PS51269", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51269" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COMM", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 183, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8V8-1", "uniprot_ac": "A0AAA9S8V8", "uniprot_id": "A0AAA9S8V8_BOVIN", "mass": { "chemical_mass": 63741.0, "monoisotopic_mass": 63741.0 }, "refseq": { "ac": "XP_005204275", "name": "potassium voltage-gated channel subfamily A member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204275" }, "gene_names": [ { "name": "KCNA3", "type": "recommended", "evidence": [ { "id": "A0AAA9S8V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ] }, { "name": "KCNA3", "type": "synonym", "evidence": [ { "id": "XP_005204275", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204275" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily A member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S8V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8/entry#names_and_taxonomy" } ] }, { "name": "potassium voltage-gated channel subfamily A member 3", "type": "synonym", "evidence": [ { "id": "XP_005204275", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204275" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8", "locus": { "chromosome": "3", "start_pos": 32767640, "end_pos": 32744983, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047879", "url": "https://www.ensembl.org/id/ENSBTAG00000047879" } ] } } ], "crossref": [ { "id": "A0AAA9S8V8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8V8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047879", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047879", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525507", "url": "https://www.ncbi.nlm.nih.gov/gene/525507", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525507", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525507", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INHSAFK", "url": "https://omabrowser.org/oma/group/INHSAFK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7K3", "url": "https://www.orthodb.org/?gene=E1B7K3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005204275", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204275", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7K3", "url": "https://www.uniprot.org/uniprotkb/E1B7K3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7K3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7K3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEHLSLLRSPPQPSARQRAHPPQQPASGGGAHTLVNPGYTEPAAGSELPPDMTVVPGDHLLEPEAADGGGDPPQGGCGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKYYTASPSQEQFEASSNSTSGGPTGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQCLHVGSCQHLSPSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQAPFKTGNSTATCTTNNNPNSCVNIKKIFTDV", "length": 576, "header": "tr|A0AAA9S8V8-1|A0AAA9S8V8_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily A member 3 OS=Bos taurus OX=9913 GN=KCNA3 PE=4 SV=1 CANONICAL=A0AAA9S8V8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8/entry#A0AAA9S8V8-1", "sequence": { "sequence": "MDEHLSLLRSPPQPSARQRAHPPQQPASGGGAHTLVNPGYTEPAAGSELPPDMTVVPGDHLLEPEAADGGGDPPQGGCGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKYYTASPSQEQFEASSNSTSGGPTGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQCLHVGSCQHLSPSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQAPFKTGNSTATCTTNNNPNSCVNIKKIFTDV", "length": 576, "header": "tr|A0AAA9S8V8-1|A0AAA9S8V8_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily A member 3 OS=Bos taurus OX=9913 GN=KCNA3 PE=4 SV=1 CANONICAL=A0AAA9S8V8-1" }, "locus": { "chromosome": "3", "start_pos": 32764132, "end_pos": 32762405, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127860.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127860.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082479.1" } ] } }, { "isoform_ac": "E1B7K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8/entry#E1B7K3-1", "sequence": { "sequence": "MDEHLSLLRSPPQPSARQRAHPPQQPASGGGAHTLVNPGYTEPAAGSELPPDMTVVPGDHLLEPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKYYTASPSQEQFEASSNSTSGGPTGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQCLHVGSCQHLSPSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQAPFKTGNSTATCTTNNNPNSCVNIKKIFTDV", "length": 513, "header": "tr|E1B7K3-1|E1B7K3_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily A member 3 OS=Bos taurus OX=9913 GN=KCNA3 PE=4 SV=2 CANONICAL=A0AAA9S8V8-1" }, "locus": { "chromosome": "3", "start_pos": 32747028, "end_pos": 32745301, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064709.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064709.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056292.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056292.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 287, "start_aa": "Thr", "end_pos": 287, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr287", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:525507", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525507", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PI60-1", "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "KCNA3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDERRSLLHSPAASSAGRPPSSSHHNLGYTEQPPPGAPQPPPGHEEEEGEEAEEGSMTVVGGAGDPLPEEPQHPHPLLGGERYEHPAPPAAGPAGHPAEVSGEHECCERVVINISGLRFETQLKTLAQFPETLLGDPRKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFIREEQRPLPEKEFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDDHDYEGTGGTFGTGGGPLPPDVFTNSSSSAVSMVSSFTDPFFVVETLCIIWFSFELLVRFFACPSKATFSKNIMNIIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFSSIPDAFWWAVVTMTTVGYGDMHPITIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSTEEMRKARSNSTLSKSEYMVIEEGGINHSAFKQAAFKTGNCTTTNNPNCVNIKKIFTDV", "length": 580 }, "evidence": [ { "id": "A0AAA9S8V8", "url": "https://omabrowser.org/oma/group/A0AAA9S8V8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P15384-1", "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "Kcna3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVVPGDHLLEPEAAGGGGGDPPQGGCVSGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV", "length": 525 }, "evidence": [ { "id": "A0AAA9S8V8", "url": "https://omabrowser.org/oma/group/A0AAA9S8V8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P16390-1", "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "Kcna3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV", "length": 528 }, "evidence": [ { "id": "A0AAA9S8V8", "url": "https://omabrowser.org/oma/group/A0AAA9S8V8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P22001-1", "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "KCNA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV", "length": 575 }, "evidence": [ { "id": "A0AAA9S8V8", "url": "https://omabrowser.org/oma/group/A0AAA9S8V8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" }, { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" }, { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8V8" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 205, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 287 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 539, "end_pos": 541 }, { "start_pos": 552, "end_pos": 554 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8W1-1", "uniprot_ac": "A0AAA9S8W1", "uniprot_id": "A0AAA9S8W1_BOVIN", "mass": { "chemical_mass": 53432.0, "monoisotopic_mass": 53432.0 }, "refseq": { "ac": "XP_024846642", "name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846642" }, "gene_names": [ { "name": "NAPEPLD", "type": "recommended", "evidence": [ { "id": "A0AAA9S8W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ] }, { "name": "NAPE-PLD", "type": "synonym", "evidence": [ { "id": "XP_024846642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846642" } ] }, { "name": "NAPEPLD", "type": "synonym", "evidence": [ { "id": "XP_024846642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846642" } ] } ], "protein_names": [ { "name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "type": "recommended", "evidence": [ { "id": "A0AAA9S8W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.54", "type": "synonym", "evidence": [ { "id": "A0AAA9S8W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1/entry#names_and_taxonomy" } ] }, { "name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024846642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846642" } ] } ], "function": [ { "annotation": "D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YZQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "database": "UniProtKB", "id": "ARBA00045525", "url": "https://www.uniprot.org/uniprotkb/ARBA00045525#function" }, { "database": "UniProtKB", "id": "A0AAF7AEE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAPEPLD", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1", "locus": { "chromosome": "4", "start_pos": 44427621, "end_pos": 44483520, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014171", "url": "https://www.ensembl.org/id/ENSBTAG00000014171" } ] } } ], "crossref": [ { "id": "A0AAA9S8W1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8W1", "database": "AlphaFoldDB", "categories": [] }, { "id": "541291", "url": "https://www.ncbi.nlm.nih.gov/gene/541291", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15032", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15032", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15032:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15032:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12706", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12706", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846642", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846642", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "45528", "url": "https://www.rhea-db.org/rhea/45528", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45532", "url": "https://www.rhea-db.org/rhea/45532", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45536", "url": "https://www.rhea-db.org/rhea/45536", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45540", "url": "https://www.rhea-db.org/rhea/45540", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45544", "url": "https://www.rhea-db.org/rhea/45544", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45552", "url": "https://www.rhea-db.org/rhea/45552", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45556", "url": "https://www.rhea-db.org/rhea/45556", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45592", "url": "https://www.rhea-db.org/rhea/45592", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45596", "url": "https://www.rhea-db.org/rhea/45596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45608", "url": "https://www.rhea-db.org/rhea/45608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45612", "url": "https://www.rhea-db.org/rhea/45612", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45616", "url": "https://www.rhea-db.org/rhea/45616", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45620", "url": "https://www.rhea-db.org/rhea/45620", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53164", "url": "https://www.rhea-db.org/rhea/53164", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56464", "url": "https://www.rhea-db.org/rhea/56464", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56548", "url": "https://www.rhea-db.org/rhea/56548", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AEE7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AEE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRRRALRRCLQLLAPLAEPARRGRGRRNSGAGLRGPSRCAGAPWPVAEELQQQKRRRARPTAPRAWSSPKNMDENETNQLLMTSNQYPKEAVRKRQNSRNSGGSDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPSLLRWVITERDHSSVPCSKELDKELPVLKPYFIDDPEEAGVRGAGLRVTWLGHATVMVEMDELILLTDPIFSARASPSQRMGPKRFRRAPCTVEELPRIDAVLVSHNHYDHLDCNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCSAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVKIHIDVQAKKSVAIHWGTFALANEHYLEPPAKLCEALEKYRLKTEDFLVLKHGESRYLNTDDEDVE", "length": 464, "header": "tr|A0AAA9S8W1-1|A0AAA9S8W1_BOVIN Isoform 1 of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Bos taurus OX=9913 GN=NAPEPLD PE=3 SV=1 CANONICAL=A0AAA9S8W1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1/entry#A0AAA9S8W1-1", "sequence": { "sequence": "MVRRRALRRCLQLLAPLAEPARRGRGRRNSGAGLRGPSRCAGAPWPVAEELQQQKRRRARPTAPRAWSSPKNMDENETNQLLMTSNQYPKEAVRKRQNSRNSGGSDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPSLLRWVITERDHSSVPCSKELDKELPVLKPYFIDDPEEAGVRGAGLRVTWLGHATVMVEMDELILLTDPIFSARASPSQRMGPKRFRRAPCTVEELPRIDAVLVSHNHYDHLDCNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCSAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVKIHIDVQAKKSVAIHWGTFALANEHYLEPPAKLCEALEKYRLKTEDFLVLKHGESRYLNTDDEDVE", "length": 464, "header": "tr|A0AAA9S8W1-1|A0AAA9S8W1_BOVIN Isoform 1 of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Bos taurus OX=9913 GN=NAPEPLD PE=3 SV=1 CANONICAL=A0AAA9S8W1-1" }, "locus": { "chromosome": "4", "start_pos": 44482842, "end_pos": 44427828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134557.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134557.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078595.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078595.1" } ] } }, { "isoform_ac": "A0AAF6YZQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1/entry#A0AAF6YZQ1-1", "sequence": { "sequence": "MSSPKNMDENETNQLLMTSNQYPKEAVRKRQNSRNSGGSDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPSLLRWVITERDHSSVPCSKELDKELPVLKPYFIDDPEEAGVRGAGLRVTWLGHATVMVEMDELILLTDPIFSARASPSQRMGPKRFRRAPCTVEELPRIDAVLVSHNHYDHLDCNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCSAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVKIHIDVQAKKSVAIHWGTFALANEHYLEPPAKLCEALEKYRLKTEDFLVLKHGESRYLNTDDEDVE", "length": 398, "header": "tr|A0AAF6YZQ1-1|A0AAF6YZQ1_BOVIN Computationally mapped isoform of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Bos taurus OX=9913 GN=NAPEPLD PE=3 SV=1 CANONICAL=A0AAA9S8W1-1" }, "locus": { "chromosome": "4", "start_pos": 44482255, "end_pos": 44427828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018833.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018833.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018833.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018833.4" } ] } }, { "isoform_ac": "A0AAF7AEE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1/entry#A0AAF7AEE7-1", "sequence": { "sequence": "MGSQRVGHGSSPKNMDENETNQLLMTSNQYPKEAVRKRQNSRNSGGSDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPSLLRWVITERDHSSVPCSKELDKELPVLKPYFIDDPEEAGVRGAGLRVTWLGHATVMVEMDELILLTDPIFSARASPSQRMGPKRFRRAPCTVEELPRIDAVLVSHNHYDHLDCNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCSAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVKIHIDVQAKKSVAIHWGTFALANEHYLEPPAKLCEALEKYRLKTEDFLVLKHGESRYLNTDDEDVE", "length": 406, "header": "tr|A0AAF7AEE7-1|A0AAF7AEE7_BOVIN Computationally mapped isoform of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Bos taurus OX=9913 GN=NAPEPLD PE=3 SV=1 CANONICAL=A0AAA9S8W1-1" }, "locus": { "chromosome": "4", "start_pos": 44483321, "end_pos": 44427828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086672.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086672.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067871.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067871.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "N-acylphosphatidylethanolamine-specific phospholipase D activity", "id": "GO:0070290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070290", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "bile acid binding", "id": "GO:0032052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "smooth endoplasmic reticulum membrane", "id": "GO:0030868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030868", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "hippocampal mossy fiber to CA3 synapse", "id": "GO:0098686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098686", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "temperature homeostasis", "id": "GO:0001659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "phospholipid catabolic process", "id": "GO:0009395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009395", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "positive regulation of brown fat cell differentiation", "id": "GO:0090336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "N-acylphosphatidylethanolamine metabolic process", "id": "GO:0070292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070292", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" }, { "name": "host-mediated modulation of intestinal microbiota composition", "id": "GO:0048874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "45528", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45528", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45528" } ] }, { "id": "45532", "name": "", "equation": "N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45532", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45532" } ] }, { "id": "45536", "name": "", "equation": "N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45536", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45536" } ] }, { "id": "45540", "name": "", "equation": "N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45540", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45540" } ] }, { "id": "45544", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45544", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45544" } ] }, { "id": "45552", "name": "", "equation": "N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-tetradecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45552", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45552" } ] }, { "id": "45556", "name": "", "equation": "N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-dodecanoylethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45556", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45556" } ] }, { "id": "45592", "name": "", "equation": "N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45592" } ] }, { "id": "45596", "name": "", "equation": "N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45596" } ] }, { "id": "45608", "name": "", "equation": "N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-decanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45608" } ] }, { "id": "45612", "name": "", "equation": "N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45612", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45612" } ] }, { "id": "45616", "name": "", "equation": "N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45616" } ] }, { "id": "45620", "name": "", "equation": "N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-butanoyl ethanolamine + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "45620", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45620" } ] }, { "id": "53164", "name": "", "equation": "N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1-acyl-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "53164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53164" } ] }, { "id": "56464", "name": "", "equation": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "56464", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56464" } ] }, { "id": "56548", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S8W1-1", "Q58CN9-1" ], "evidence": [ { "id": "56548", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56548" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S8W1", "gene_name": "NAPEPLD", "activity": [ { "ec_number": "3.1.4.54", "activity": "an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+).", "evidence": [ { "id": "A0AAA9S8W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ] }, { "ec_number": "3.1.4.54", "activity": "", "evidence": [ { "id": "A0AAA9S8W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" } ] } ] }, { "uniprot_ac": "Q58CN9", "gene_name": "NAPEPLD", "activity": [ { "ec_number": "3.1.4.54", "activity": "an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+).", "evidence": [ { "id": "Q58CN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CN9" } ] }, { "ec_number": "3.1.4.54", "activity": "", "evidence": [ { "id": "Q58CN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CN9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W1" }, { "id": "PF12706", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12706" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Metallo-beta-lactamase", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 414, "start_aa": "Leu", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 189, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 189, "end_pos": 189, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 191, "amino_acid": "Arg", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 191, "end_pos": 191, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 193, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 193, "end_pos": 193, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 194, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 194, "end_pos": 194, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 197, "amino_acid": "Val", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 197, "end_pos": 197, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 199, "amino_acid": "Trp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 199, "end_pos": 199, "start_aa": "Trp", "end_aa": "Trp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 201, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 201, "end_pos": 201, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 202, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 202, "end_pos": 202, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 257, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 257, "end_pos": 257, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 265, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 265, "end_pos": 265, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 288, "amino_acid": "Trp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 288, "end_pos": 288, "start_aa": "Trp", "end_aa": "Trp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 296, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 296, "end_pos": 296, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1#function" }, { "id": "A0AAF6YZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZQ1" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 347, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 347, "end_pos": 347, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7#function" }, { "id": "A0AAF7AEE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEE7" }, { "id": "PIRSR038896-51", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038896-51" } ], "binding_site_uniprot": 355, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 355, "end_pos": 355, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.4.54", "ec_name": "an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+).", "evidence": [ { "id": "3.1.4.54", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.54" }, { "id": "3.1.4.54", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.54" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8W4-1", "uniprot_ac": "A0AAA9S8W4", "uniprot_id": "A0AAA9S8W4_BOVIN", "mass": { "chemical_mass": 34594.0, "monoisotopic_mass": 34594.0 }, "refseq": { "ac": "XP_002693775", "name": "olfactory receptor 4A47", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693775" }, "gene_names": [ { "name": "OR4A2B", "type": "recommended", "evidence": [ { "id": "A0AAA9S8W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4" } ] }, { "name": "OR4A2B", "type": "synonym", "evidence": [ { "id": "XP_002693775", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693775" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S8W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4A47", "type": "synonym", "evidence": [ { "id": "XP_002693775", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693775" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4A2B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S8W4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8W4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523060", "url": "https://www.ncbi.nlm.nih.gov/gene/523060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523060", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002693775", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693775", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQRINVTEFVLLGLTQSPQGQKILFVIFLLIYLVTMVGNLLIVLTVVSSPTLHVPMYFFLGNLSFMDAVYSTTVTPNMIIDLFYVKKTISFQACMIQLFTEHLFGGAEILLLVVMAYDRYVAICKPLHYMTIMNQWVCTLLLLLAWTGGFLHAIIHILFVYNLPFCGPNVIDHFGCDMYPLLKLACTDIHIIGFSVLANDGAICVVLFTLLLVSYGVILRSLKNLSQEGRRKALSTCGSHVTVVVLFFVPCVFLYVRPPSTLPTDKSLAVFYTIVTPMLNPLIYTLRNEEMQNAMKKLWIRRRK", "length": 305, "header": "tr|A0AAA9S8W4-1|A0AAA9S8W4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A2B PE=3 SV=2 CANONICAL=A0AAA9S8W4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4/entry#A0AAA9S8W4-1", "sequence": { "sequence": "MEQRINVTEFVLLGLTQSPQGQKILFVIFLLIYLVTMVGNLLIVLTVVSSPTLHVPMYFFLGNLSFMDAVYSTTVTPNMIIDLFYVKKTISFQACMIQLFTEHLFGGAEILLLVVMAYDRYVAICKPLHYMTIMNQWVCTLLLLLAWTGGFLHAIIHILFVYNLPFCGPNVIDHFGCDMYPLLKLACTDIHIIGFSVLANDGAICVVLFTLLLVSYGVILRSLKNLSQEGRRKALSTCGSHVTVVVLFFVPCVFLYVRPPSTLPTDKSLAVFYTIVTPMLNPLIYTLRNEEMQNAMKKLWIRRRK", "length": 305, "header": "tr|A0AAA9S8W4-1|A0AAA9S8W4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A2B PE=3 SV=2 CANONICAL=A0AAA9S8W4-1" }, "locus": { "chromosome": "15", "start_pos": 78356111, "end_pos": 78355197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096436.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096436.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080356.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080356.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523060", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8W4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 285, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8X1-1", "uniprot_ac": "A0AAA9S8X1", "uniprot_id": "A0AAA9S8X1_BOVIN", "mass": { "chemical_mass": 53402.0, "monoisotopic_mass": 53402.0 }, "refseq": { "ac": "XP_024837941", "name": "REST corepressor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837941" }, "gene_names": [ { "name": "RCOR1", "type": "recommended", "evidence": [ { "id": "A0AAA9S8X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ] }, { "name": "RCOR1", "type": "synonym", "evidence": [ { "id": "XP_024837941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837941" } ] } ], "protein_names": [ { "name": "REST corepressor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024837941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837941" } ] }, { "name": "REST corepressor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S8X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RCOR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1", "locus": { "chromosome": "21", "start_pos": 67435237, "end_pos": 67320697, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002336", "url": "https://www.ensembl.org/id/ENSBTAG00000002336" } ] } } ], "crossref": [ { "id": "A0AAA9S8X1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8X1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002336", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002336", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506525", "url": "https://www.ncbi.nlm.nih.gov/gene/506525", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506525", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506525", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFFVSYR", "url": "https://omabrowser.org/oma/group/HFFVSYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKY8", "url": "https://www.orthodb.org/?gene=F1MKY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00249", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00249", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20878", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20878", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214815", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024837941", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837941", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY8", "url": "https://www.uniprot.org/uniprotkb/F1MKY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY8-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAMVEKGPEVSGKRRGRNNASSAAASAAAAASAAASAAAAASAAAASSVAAASAAASASAAAAPNNGQNKSLAAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARRQKREREESEDELEETNGNNPIDMEIDQNKESKKEVPPTETIPQIKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDLELVSIKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEENGPSNQKPVKSPDSSIKMPEEDDEAASVLDVRYASAS", "length": 486, "header": "tr|A0AAA9S8X1-1|A0AAA9S8X1_BOVIN Isoform 1 of REST corepressor 1 OS=Bos taurus OX=9913 GN=RCOR1 PE=3 SV=1 CANONICAL=A0AAA9S8X1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1/entry#A0AAA9S8X1-1", "sequence": { "sequence": "MPAMVEKGPEVSGKRRGRNNASSAAASAAAAASAAASAAAAASAAAASSVAAASAAASASAAAAPNNGQNKSLAAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARRQKREREESEDELEETNGNNPIDMEIDQNKESKKEVPPTETIPQIKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDLELVSIKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEENGPSNQKPVKSPDSSIKMPEEDDEAASVLDVRYASAS", "length": 486, "header": "tr|A0AAA9S8X1-1|A0AAA9S8X1_BOVIN Isoform 1 of REST corepressor 1 OS=Bos taurus OX=9913 GN=RCOR1 PE=3 SV=1 CANONICAL=A0AAA9S8X1-1" }, "locus": { "chromosome": "21", "start_pos": 67434233, "end_pos": 67320896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122264.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122264.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078605.1" } ] } }, { "isoform_ac": "F1MKY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1/entry#F1MKY8-1", "sequence": { "sequence": "MPAMVEKGPEVSGKRRGRNNASSAAASAAAAASAAASAAAAASAAAASSVAAASAAASASAAAAPNNGQNKSLAAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARRQKREREESEDELEETNGNNPIDMEIDQNKESKKEVPPTETIPQIKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDLELVSIKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEENGPSNQKPVKSPDSSIKMPEEDDEVSSQPAPAELA", "length": 484, "header": "tr|F1MKY8-1|F1MKY8_BOVIN Computationally mapped isoform of REST corepressor 1 OS=Bos taurus OX=9913 GN=RCOR1 PE=3 SV=4 CANONICAL=A0AAA9S8X1-1" }, "locus": { "chromosome": "21", "start_pos": 67432655, "end_pos": 67320896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003016.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003016.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003016.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003016.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506525", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506525", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "resource": "Reactome", "description": "HDACs deacetylate histones" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "M0R3J8-1", "protein_name": "REST corepressor 1", "gene_name": "Rcor1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAMVEKGPEVSGKRRGRNTASAAASAAAASAASAAASAAASAGTASASAAATASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEPNGSNPVDIDIDPNRESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSIKRQIQNMKQTNSALKEKLAGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFSIDEVLQEWEAEHGKEEANGPTNQKPAKSPESSVKIQEEEDEAASVLDVRYASAS", "length": 481 }, "evidence": [ { "id": "A0AAA9S8X1", "url": "https://omabrowser.org/oma/group/A0AAA9S8X1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UKL0-1", "protein_name": "REST corepressor 1", "gene_name": "RCOR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS", "length": 485 }, "evidence": [ { "id": "A0AAA9S8X1", "url": "https://omabrowser.org/oma/group/A0AAA9S8X1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "positive regulation of megakaryocyte differentiation", "id": "GO:0045654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "histone methyltransferase complex", "id": "GO:0035097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035097", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "DNA repair complex", "id": "GO:1990391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990391", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" }, { "id": "PS51156", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51156" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ELM2", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 190, "start_aa": "Gly", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X1" }, { "id": "PS51293", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51293" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SANT", "eco_id": "ECO_0000259", "start_pos": 191, "end_pos": 242, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 20, "end_pos": 22 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8X8-1", "uniprot_ac": "A0AAA9S8X8", "uniprot_id": "A0AAA9S8X8_BOVIN", "mass": { "chemical_mass": 36129.0, "monoisotopic_mass": 36129.0 }, "refseq": { "ac": "NP_001377579", "name": "olfactory receptor family 6 subfamily C member 277", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377579" }, "gene_names": [ { "name": "OR6C277", "type": "recommended", "evidence": [ { "id": "A0AAA9S8X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8" } ] }, { "name": "OR6C277", "type": "synonym", "evidence": [ { "id": "NP_001377579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377579" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S8X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 6 subfamily C member 277", "type": "synonym", "evidence": [ { "id": "NP_001377579", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377579" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377579" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C277", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8", "locus": { "chromosome": "5", "start_pos": 58018151, "end_pos": 58019086, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064972", "url": "https://www.ensembl.org/id/ENSBTAG00000064972" } ] } } ], "crossref": [ { "id": "A0AAA9S8X8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8X8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140445", "url": "https://www.ncbi.nlm.nih.gov/gene/100140445", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140445", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140445", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377579", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNHTPVFSFILQGLTDNLQMQILTFIFLLITYMLNIIGNLVIITLILVDSHLKTAMYFFLQNFSFLEISFTSACIPRFLYSILTGDRTITYNACLSQLFFTYMFGVTEFFLLATMSYDRYVAICKPLHYMTIMNHRFCKMLTFCCWITTFLIVFPPFCLGLNLEFCDSVIDHFFCDFYPLLKISCSDPWFMEEITLVCCVLIFIMTLTCVVLSYICIIRTVLRFPSAQQRTKAFSTCSSHFIVVSITYGSCIFVYIKPSSKDEVTINKQVVILTTSISPMLNPFIYTLRNKQVKQAFKDLLKRILLVSKN", "length": 311, "header": "tr|A0AAA9S8X8-1|A0AAA9S8X8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C277 PE=3 SV=1 CANONICAL=A0AAA9S8X8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8/entry#A0AAA9S8X8-1", "sequence": { "sequence": "MRNHTPVFSFILQGLTDNLQMQILTFIFLLITYMLNIIGNLVIITLILVDSHLKTAMYFFLQNFSFLEISFTSACIPRFLYSILTGDRTITYNACLSQLFFTYMFGVTEFFLLATMSYDRYVAICKPLHYMTIMNHRFCKMLTFCCWITTFLIVFPPFCLGLNLEFCDSVIDHFFCDFYPLLKISCSDPWFMEEITLVCCVLIFIMTLTCVVLSYICIIRTVLRFPSAQQRTKAFSTCSSHFIVVSITYGSCIFVYIKPSSKDEVTINKQVVILTTSISPMLNPFIYTLRNKQVKQAFKDLLKRILLVSKN", "length": 311, "header": "tr|A0AAA9S8X8-1|A0AAA9S8X8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C277 PE=3 SV=1 CANONICAL=A0AAA9S8X8-1" }, "locus": { "chromosome": "5", "start_pos": 58019086, "end_pos": 58018154, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129249.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129249.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081739.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140445", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140445", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8X8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8Z6-1", "uniprot_ac": "A0AAA9S8Z6", "uniprot_id": "A0AAA9S8Z6_BOVIN", "mass": { "chemical_mass": 35096.0, "monoisotopic_mass": 35096.0 }, "refseq": { "ac": "NP_001377470", "name": "olfactory receptor family 4 subfamily L member 19", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377470" }, "gene_names": [ { "name": "OR4L19", "type": "recommended", "evidence": [ { "id": "A0AAA9S8Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6" } ] }, { "name": "OR4L19", "type": "synonym", "evidence": [ { "id": "NP_001377470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377470" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S8Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4K13", "type": "synonym", "evidence": [ { "id": "NP_001377470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377470" } ] }, { "name": "olfactory receptor family 4 subfamily L member 19", "type": "synonym", "evidence": [ { "id": "NP_001377470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377470" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377470" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4L19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6", "locus": { "chromosome": "10", "start_pos": 27503759, "end_pos": 27502818, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058477", "url": "https://www.ensembl.org/id/ENSBTAG00000058477" } ] } } ], "crossref": [ { "id": "A0AAA9S8Z6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S8Z6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788100", "url": "https://www.ncbi.nlm.nih.gov/gene/788100", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788100", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788100", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377470", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLLNNRSSVSEFVLVGLSTSQETQILFFAIFFLVYVAIIVGNLLIVISVIVDNHLHSPMYFFLANLSFFDLCLSSAATPKVISDFLRKHKTISWWGCMTQMFFMHFFGGGEMSLLIAMAVDRYVAICKPLHYKTIMSHRVLTGFLLLSWVIGLIHTTSQMVFTVGLPFCGPNVLDSFFCDLPLVIKLACTETYILELLVIVNSGLLSLLCFILLLISYVVMLVTIWKHSSSASSKALSTLSAHITVVTLFFGPAIFIYAFPFNGYSVDKFLSMFYSIITPLLNPIIYTLRNQEMKAAIKRLSKHHIGAGLTH", "length": 313, "header": "tr|A0AAA9S8Z6-1|A0AAA9S8Z6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4L19 PE=3 SV=1 CANONICAL=A0AAA9S8Z6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6/entry#A0AAA9S8Z6-1", "sequence": { "sequence": "MDLLNNRSSVSEFVLVGLSTSQETQILFFAIFFLVYVAIIVGNLLIVISVIVDNHLHSPMYFFLANLSFFDLCLSSAATPKVISDFLRKHKTISWWGCMTQMFFMHFFGGGEMSLLIAMAVDRYVAICKPLHYKTIMSHRVLTGFLLLSWVIGLIHTTSQMVFTVGLPFCGPNVLDSFFCDLPLVIKLACTETYILELLVIVNSGLLSLLCFILLLISYVVMLVTIWKHSSSASSKALSTLSAHITVVTLFFGPAIFIYAFPFNGYSVDKFLSMFYSIITPLLNPIIYTLRNQEMKAAIKRLSKHHIGAGLTH", "length": 313, "header": "tr|A0AAA9S8Z6-1|A0AAA9S8Z6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4L19 PE=3 SV=1 CANONICAL=A0AAA9S8Z6-1" }, "locus": { "chromosome": "10", "start_pos": 27503756, "end_pos": 27502818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098403.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098403.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082533.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788100", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788100", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 66, "end_pos": 68 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S911-1", "uniprot_ac": "A0AAA9S911", "uniprot_id": "A0AAA9S911_BOVIN", "mass": { "chemical_mass": 103122.0, "monoisotopic_mass": 103122.0 }, "refseq": {}, "gene_names": [ { "name": "FBXO11", "type": "recommended", "evidence": [ { "id": "A0AAA9S911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ] } ], "protein_names": [ { "name": "F-box only protein 11", "type": "recommended", "evidence": [ { "id": "A0AAA9S911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911", "locus": { "chromosome": "11", "start_pos": 30143483, "end_pos": 30255619, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001425", "url": "https://www.ensembl.org/id/ENSBTAG00000001425" } ] } } ], "crossref": [ { "id": "A0AAA9S911", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S911", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001425", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001425", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19676", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19676", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22091", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22091", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508172", "url": "https://www.ncbi.nlm.nih.gov/gene/508172", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9Q3", "url": "https://www.orthodb.org/?gene=E1B9Q3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22990", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22990", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22990:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22990:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S911-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q3", "url": "https://www.uniprot.org/uniprotkb/E1B9Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQPPPPPPPPPPLPQERNNAGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPYLKYLPMLQEETVLKMDTQGQLTL", "length": 921, "header": "tr|A0AAA9S911-1|A0AAA9S911_BOVIN Isoform 1 of F-box only protein 11 OS=Bos taurus OX=9913 GN=FBXO11 PE=4 SV=1 CANONICAL=A0AAA9S911-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S911-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911/entry#A0AAA9S911-1", "sequence": { "sequence": "MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQPPPPPPPPPPLPQERNNAGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPYLKYLPMLQEETVLKMDTQGQLTL", "length": 921, "header": "tr|A0AAA9S911-1|A0AAA9S911_BOVIN Isoform 1 of F-box only protein 11 OS=Bos taurus OX=9913 GN=FBXO11 PE=4 SV=1 CANONICAL=A0AAA9S911-1" }, "locus": { "chromosome": "11", "start_pos": 30255420, "end_pos": 30144487, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082551.1" } ] } }, { "isoform_ac": "A0AAA9TNA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911/entry#A0AAA9TNA9-1", "sequence": { "sequence": "MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQPPPPPPPPPPLPQERNNAGERDMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN", "length": 920, "header": "tr|A0AAA9TNA9-1|A0AAA9TNA9_BOVIN Computationally mapped isoform of F-box only protein 11 OS=Bos taurus OX=9913 GN=FBXO11 PE=4 SV=1 CANONICAL=A0AAA9S911-1" }, "locus": { "chromosome": "11", "start_pos": 30255420, "end_pos": 30144642, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126004.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126004.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098753.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098753.1" } ] } }, { "isoform_ac": "E1B9Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911/entry#E1B9Q3-1", "sequence": { "sequence": "MHLESSWTRDQICDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN", "length": 864, "header": "tr|E1B9Q3-1|E1B9Q3_BOVIN Computationally mapped isoform of F-box only protein 11 OS=Bos taurus OX=9913 GN=FBXO11 PE=4 SV=4 CANONICAL=A0AAA9S911-1" }, "locus": { "chromosome": "11", "start_pos": 30236989, "end_pos": 30144642, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001868.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001868.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001868.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001868.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "protein-arginine N-methyltransferase activity", "id": "GO:0016274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016274", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "negative regulation of epithelial to mesenchymal transition", "id": "GO:0010719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010719", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S911", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 810, "end_pos": 812, "annotation": "n_glycosylation_sequon" }, { "start_pos": 856, "end_pos": 858, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 152, "end_pos": 198, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S911" }, { "id": "PS51157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBR-type", "eco_id": "ECO_0000259", "start_pos": 832, "end_pos": 904, "start_aa": "Gly", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 368, "end_pos": 370 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 810, "end_pos": 812 }, { "start_pos": 856, "end_pos": 858 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S951-1", "uniprot_ac": "A0AAA9S951", "uniprot_id": "A0AAA9S951_BOVIN", "mass": { "chemical_mass": 27265.0, "monoisotopic_mass": 27265.0 }, "refseq": { "ac": "XP_005209211", "name": "ADP-ribosylation factor-like protein 10 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209211" }, "gene_names": [ { "name": "ARL10", "type": "recommended", "evidence": [ { "id": "A0AAA9S951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" } ] }, { "name": "ARL10", "type": "synonym", "evidence": [ { "id": "XP_005209211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209211" } ] } ], "protein_names": [ { "name": "ADP ribosylation factor like GTPase 10", "type": "synonym", "evidence": [ { "id": "A0AAA9S951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-like protein 10 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209211" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S951", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951", "locus": { "chromosome": "7", "start_pos": 37856332, "end_pos": 37840059, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025345", "url": "https://www.ensembl.org/id/ENSBTAG00000025345" } ] } } ], "crossref": [ { "id": "A0AAA9S951", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S951", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04162", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04162", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614282", "url": "https://www.ncbi.nlm.nih.gov/gene/614282", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "THALVYV", "url": "https://omabrowser.org/oma/group/THALVYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR47575", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47575", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47575:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47575:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209211", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209211", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S951", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S951-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPRPLSPLVLALGGAAAVLGSVLFILWKTYFGSGRERRWDGGEAWWGAEPAGLPQWDEWDPEDEEDVEPALEELEQREVLVLGLDGSGKSTFLRVLAGKPPLEGHIPTWGFNSVRLPTRNFEVDLLEIGGSQNLRFYWKEFVNEVDVLVFMVDSADRLRLPWARQELHKLLDKDPDLPVVVVANKQDLSEAMSMVELQQELGLQAVDSQRELFLLAASIAPAGTSFENPGTVHIWKLLLELLS", "length": 244, "header": "tr|A0AAA9S951-1|A0AAA9S951_BOVIN Isoform 1 of ADP ribosylation factor like GTPase 10 OS=Bos taurus OX=9913 GN=ARL10 PE=4 SV=1 CANONICAL=A0AAA9S951-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S951-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951/entry#A0AAA9S951-1", "sequence": { "sequence": "MAPRPLSPLVLALGGAAAVLGSVLFILWKTYFGSGRERRWDGGEAWWGAEPAGLPQWDEWDPEDEEDVEPALEELEQREVLVLGLDGSGKSTFLRVLAGKPPLEGHIPTWGFNSVRLPTRNFEVDLLEIGGSQNLRFYWKEFVNEVDVLVFMVDSADRLRLPWARQELHKLLDKDPDLPVVVVANKQDLSEAMSMVELQQELGLQAVDSQRELFLLAASIAPAGTSFENPGTVHIWKLLLELLS", "length": 244, "header": "tr|A0AAA9S951-1|A0AAA9S951_BOVIN Isoform 1 of ADP ribosylation factor like GTPase 10 OS=Bos taurus OX=9913 GN=ARL10 PE=4 SV=1 CANONICAL=A0AAA9S951-1" }, "locus": { "chromosome": "7", "start_pos": 37846093, "end_pos": 37840132, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128413.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128413.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080453.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S951", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S951", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S951", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9S951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951#function" }, { "id": "A0AAA9S951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 109, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 109, "end_pos": 109, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951#function" }, { "id": "A0AAA9S951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S951" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 91, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 91, "end_pos": 91, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S977-1", "uniprot_ac": "A0AAA9S977", "uniprot_id": "A0AAA9S977_BOVIN", "mass": { "chemical_mass": 56227.0, "monoisotopic_mass": 56227.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF2", "type": "recommended", "evidence": [ { "id": "A0AAA9S977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ] } ], "protein_names": [ { "name": "Zinc finger protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9S977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9T4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Z6#function" }, { "database": "UniProtKB", "id": "A0AAA9SZU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977", "locus": { "chromosome": "11", "start_pos": 1985582, "end_pos": 1975215, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055838", "url": "https://www.ensembl.org/id/ENSBTAG00000055838" } ] } } ], "crossref": [ { "id": "A0AAA9S977", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S977", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S977-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCVCLLCVQRRPCSDKCGLGKLYPHPSVCVFRVGTVSSGLSACPHYMSDPGSAVGSLEASFAPPDSALLCKESTLEGMAAVSPTRCQDPVTFEDVAVVFTDEEWRRLVPTQRDLYKEVMLENYKSIVSLGLPVPGPDVIFQLKRGDEPWLVEFHGFEGKEGAENVSLDWETKPEIQGASEEEKSEGSLKENLGRKGPPSPKVEVYVLDGRLGTEKESPTVEACKKPPSLEESLRHRATPPKKFLTKERDQECSNCGKTFFDHSSLIRHQRTHTGEKPYDCPECGKAFSHRSSLSRHLMSHTGESPYECNACGKAFFDRSSLTVHQRIHTGEKPFKCSECGKAFFDRSSLTRHQRIHTGESPYECNQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGEPRYQCSECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECSVCGKVFSSKSSVIQHQRRYAKQGID", "length": 502, "header": "tr|A0AAA9S977-1|A0AAA9S977_BOVIN Isoform 1 of Zinc finger protein 2 OS=Bos taurus OX=9913 GN=ZNF2 PE=3 SV=1 CANONICAL=A0AAA9S977-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S977-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977/entry#A0AAA9S977-1", "sequence": { "sequence": "MCVCLLCVQRRPCSDKCGLGKLYPHPSVCVFRVGTVSSGLSACPHYMSDPGSAVGSLEASFAPPDSALLCKESTLEGMAAVSPTRCQDPVTFEDVAVVFTDEEWRRLVPTQRDLYKEVMLENYKSIVSLGLPVPGPDVIFQLKRGDEPWLVEFHGFEGKEGAENVSLDWETKPEIQGASEEEKSEGSLKENLGRKGPPSPKVEVYVLDGRLGTEKESPTVEACKKPPSLEESLRHRATPPKKFLTKERDQECSNCGKTFFDHSSLIRHQRTHTGEKPYDCPECGKAFSHRSSLSRHLMSHTGESPYECNACGKAFFDRSSLTVHQRIHTGEKPFKCSECGKAFFDRSSLTRHQRIHTGESPYECNQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGEPRYQCSECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECSVCGKVFSSKSSVIQHQRRYAKQGID", "length": 502, "header": "tr|A0AAA9S977-1|A0AAA9S977_BOVIN Isoform 1 of Zinc finger protein 2 OS=Bos taurus OX=9913 GN=ZNF2 PE=3 SV=1 CANONICAL=A0AAA9S977-1" }, "locus": { "chromosome": "11", "start_pos": 1984722, "end_pos": 1975523, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095052.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095052.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082625.1" } ] } }, { "isoform_ac": "A0AAA9SZU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977/entry#A0AAA9SZU4-1", "sequence": { "sequence": "MAAVSPTRCQDPVTFEDVAVVFTDEEWRRLVPTQRDLYKEVMLENYKSIVSLDWETKPEIQGASEEEKSEGSLKENLGRKGPPSPKVEVYVLDGRLGTEKESPTVEACKKPPSLEESLRHRATPPKKFLTKERDQECSNCGKTFFDHSSLIRHQRTHTGEKPYDCPECGKAFSHRSSLSRHLMSHTGESPYECNACGKAFFDRSSLTVHQRIHTGEKPFKCSECGKAFFDRSSLTRHQRIHTGESPYECNQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGEPRYQCSECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECSVCGKVFSSKSSVIQHQRRYAKQGID", "length": 387, "header": "tr|A0AAA9SZU4-1|A0AAA9SZU4_BOVIN Computationally mapped isoform of Zinc finger protein 2 OS=Bos taurus OX=9913 GN=ZNF2 PE=3 SV=1 CANONICAL=A0AAA9S977-1" }, "locus": { "chromosome": "11", "start_pos": 1984722, "end_pos": 1980213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116080.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116080.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088903.1" } ] } }, { "isoform_ac": "A0AAA9T4Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977/entry#A0AAA9T4Z6-1", "sequence": { "sequence": "MSSFETRPQISPRDSALLCKESTLEGMAAVSPTRCQDPVTFEDVAVVFTDEEWRRLVPTQRDLYKEVMLENYKSIVSLGLPVPGPDVIFQLKRGDEPWLVEFHGFEGKEGAENVSLDWETKPEIQGASEEEKSEGSLKENLGRKGPPSPKVEVYVLDGRLGTEKESPTVEACKKPPSLEESLRHRATPPKKFLTKERDQECSNCGKTFFDHSSLIRHQRTHTGEKPYDCPECGKAFSHRSSLSRHLMSHTGESPYECNACGKAFFDRSSLTVHQRIHTGEKPFKCSECGKAFFDRSSLTRHQRIHTGESPYECNQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGEPRYQCSECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECSVCGKVFSSKSSVIQHQRRYAKQGID", "length": 451, "header": "tr|A0AAA9T4Z6-1|A0AAA9T4Z6_BOVIN Computationally mapped isoform of Zinc finger protein 2 OS=Bos taurus OX=9913 GN=ZNF2 PE=3 SV=1 CANONICAL=A0AAA9S977-1" }, "locus": { "chromosome": "11", "start_pos": 1984722, "end_pos": 1979343, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117841.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117841.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090804.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090804.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S977", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 250, "end_pos": 277, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S977" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 161, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S986-1", "uniprot_ac": "A0AAA9S986", "uniprot_id": "A0AAA9S986_BOVIN", "mass": { "chemical_mass": 65160.0, "monoisotopic_mass": 65160.0 }, "refseq": {}, "gene_names": [ { "name": "FAM149B1", "type": "recommended", "evidence": [ { "id": "A0AAA9S986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 149 member B1", "type": "synonym", "evidence": [ { "id": "A0AAA9S986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S986", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM149B1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986", "locus": { "chromosome": "28", "start_pos": 29287847, "end_pos": 29237038, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019130", "url": "https://www.ensembl.org/id/ENSBTAG00000019130" } ] } } ], "crossref": [ { "id": "A0AAA9S986", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S986", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR022194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31997:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31997:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S986", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S986-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z638", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z638", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z638-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z638-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSRYTRKAVPQNLELKRITKHALNHHPLPEQLDEISSTNDSHEKDLSSQSESDITQESLFTSADTGNSTSAFPSYTSTGISTEGSSDFSWGYGELDQNATEKVQAMFTAIDELLYEQELSVHTKSLREECQQWTRSFPHLRILGRQIITPSEGYGLYPRSPSAVSASREATLSQERDSTIFGIRGKKLHFSSSYGPKASSIAKSPCLCSMEREEDCIIFSEGIIEEYLAFDHTDMEEEFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDDVWSKVLSCMEQLTRTHWEGFASDDESNVAITRPASQSPCVLSELQPLVLPRVPQSKVLSVTSHPMSLCQAASGHQPNVNGLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTIFSTRNWPNRALKLSTSFLSYTVQSARRRNPPPRTLHPISTSHSRAGTPRLMDEIRRGSRVPVAADSLSSPSPLPLSRNNLLPPIGTAEAEHLSTVGPQRQTKTHSDSSRARSAVVDEPNHQQPQEKLLLPDFFSRPNTTQSFLVLSYMDLQNLKTEVDQSLEPGRDRSTNEENLLRAAGNTWEDFTNQCSVIS", "length": 584, "header": "tr|A0AAA9S986-1|A0AAA9S986_BOVIN Isoform 1 of Family with sequence similarity 149 member B1 OS=Bos taurus OX=9913 GN=FAM149B1 PE=3 SV=1 CANONICAL=A0AAA9S986-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S986-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986/entry#A0AAA9S986-1", "sequence": { "sequence": "MTSRYTRKAVPQNLELKRITKHALNHHPLPEQLDEISSTNDSHEKDLSSQSESDITQESLFTSADTGNSTSAFPSYTSTGISTEGSSDFSWGYGELDQNATEKVQAMFTAIDELLYEQELSVHTKSLREECQQWTRSFPHLRILGRQIITPSEGYGLYPRSPSAVSASREATLSQERDSTIFGIRGKKLHFSSSYGPKASSIAKSPCLCSMEREEDCIIFSEGIIEEYLAFDHTDMEEEFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDDVWSKVLSCMEQLTRTHWEGFASDDESNVAITRPASQSPCVLSELQPLVLPRVPQSKVLSVTSHPMSLCQAASGHQPNVNGLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTIFSTRNWPNRALKLSTSFLSYTVQSARRRNPPPRTLHPISTSHSRAGTPRLMDEIRRGSRVPVAADSLSSPSPLPLSRNNLLPPIGTAEAEHLSTVGPQRQTKTHSDSSRARSAVVDEPNHQQPQEKLLLPDFFSRPNTTQSFLVLSYMDLQNLKTEVDQSLEPGRDRSTNEENLLRAAGNTWEDFTNQCSVIS", "length": 584, "header": "tr|A0AAA9S986-1|A0AAA9S986_BOVIN Isoform 1 of Family with sequence similarity 149 member B1 OS=Bos taurus OX=9913 GN=FAM149B1 PE=3 SV=1 CANONICAL=A0AAA9S986-1" }, "locus": { "chromosome": "28", "start_pos": 29286843, "end_pos": 29237189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082635.1" } ] } }, { "isoform_ac": "A0AAA9SA49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986/entry#A0AAA9SA49-1", "sequence": { "sequence": "MELDQNATEKVQAMFTAIDELLYEQELSVHTKSLREECQQWTRSFPHLRILGRQIITPSEGYGLYPRSPSAVSASREATLSQERDSTIFGIRGKKLHFSSSYGPKASSIAKSPCLCSMEREEDCIIFSEGIIEEYLAFDHTDMEEEFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDDVWSKVLSCMEQLTRTHWEGFASDDESNVAITRPASQSPCVLSELQPLVLPRVPQSKVLSVTSHPMSLCQAASGHQPNVNGLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTIFSTRNWPNRALKLSTSFLSYTVQSARRRNPPPRTLHPISTSHSRAGTPRLMDEIRRGSRVPVAADSLSSPSPLPLSRNNLLPPIGTAEAEHLSTVGPQRQTKTHSDSSRARSAVVDEPNHQQPQEKLLLPDFFSRPNTTQSFLPDTQYRRVCAAEYPHQARPGPQLHGSTKSQNRSGPISRTRQGP", "length": 484, "header": "tr|A0AAA9SA49-1|A0AAA9SA49_BOVIN Computationally mapped isoform of Family with sequence similarity 149 member B1 OS=Bos taurus OX=9913 GN=FAM149B1 PE=3 SV=1 CANONICAL=A0AAA9S986-1" }, "locus": { "chromosome": "28", "start_pos": 29286764, "end_pos": 29243280, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126087.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126087.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079042.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079042.1" } ] } }, { "isoform_ac": "A0AAA9TIN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986/entry#A0AAA9TIN1-1", "sequence": { "sequence": "MTSRYTRKAVPQNLELKRITKHALNHHPLPEQLDEISSTNDSHEKDLSSQSESDITQESLFTSADTGNSTSAFPSYTSTGISTEGSSDFSWGYGELDQNATEKVQAMFTAIDELLYEQELSVHTKSLREECQQWTRSFPHLRILGRQIITPSEGYGLYPRSPSAVSASREATLSQERDSTIFGIRGKKLHFSSSYGPKASSIAKSPCLCSMEREEDCIIFSEGIIEEYLAFDHTDMEEEFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDDVWSKVLSCMEQLTRTHWEGFASDDESNVAITRPASQSPCVLSELQPLVLPRVPQSKVLSVTSHPMSLCQAASGHQPNVNGLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTIFSTRNWPNRALKLSTSFLSYTVQSARRRNPPPRTLHPISTSHSRAGTPRLMDEIRRGSRVPVAADSLSSPSPLPLSRNNLLPPIGTAEAEHLSTVGPQRQTKTHSDSSRARSAVVDEPNHQQPQEKLLLPDFFSRPNTTQSFLPDTQYRRVCAAEYPHQARPGRGSAGTGGVMALILLQSC", "length": 572, "header": "tr|A0AAA9TIN1-1|A0AAA9TIN1_BOVIN Computationally mapped isoform of Family with sequence similarity 149 member B1 OS=Bos taurus OX=9913 GN=FAM149B1 PE=3 SV=1 CANONICAL=A0AAA9S986-1" }, "locus": { "chromosome": "28", "start_pos": 29285549, "end_pos": 29237189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096763.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096763.1" } ] } }, { "isoform_ac": "A0AAF6Z638-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986/entry#A0AAF6Z638-1", "sequence": { "sequence": "MTSRYTRKAVPQNLELKRITKHALNHHPLPEQLDEISSTNDSHEKDLSSQRILGRQIITPSEGYGLYPRSPSAVSASREATLSQERDSTIFGIRGKKLHFSSSYGPKASSIAKSPCLCSMEREEDCIIFSEGIIEEYLAFDHTDMEEEFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDDVWSKVLSCMEQLTRTHWEGFASDDESNVAITRPASQSPCVLSELQPLVLPRVPQSKVLSVTSHPMSLCQAASGHQPNVNGLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTIFSTRNWPNRALKLSTSFLSYTVQSARRRNPPPRTLHPISTSHSRAGTPRLMDEIRRGSRVPVAADSLSSPSPLPLSRNNLLPPIGTAEAEHLSTVGPQRQTKTHSDSSRARSAVVDEPNHQQPQEKLLLPDFFSRPNTTQSFLPDTQYRRVCAAEYPHQARPGRGSAGTGPQLHGSTKSQNRSGPISRTRQGP", "length": 493, "header": "tr|A0AAF6Z638-1|A0AAF6Z638_BOVIN Computationally mapped isoform of Family with sequence similarity 149 member B1 OS=Bos taurus OX=9913 GN=FAM149B1 PE=3 SV=1 CANONICAL=A0AAA9S986-1" }, "locus": { "chromosome": "28", "start_pos": 29286764, "end_pos": 29237189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025465.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025465.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025465.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025465.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S986", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S986", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 528, "end_pos": 530, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S986" }, { "id": "PF12516", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12516" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF3719", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 179, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 368, "end_pos": 370 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 528, "end_pos": 530 }, { "start_pos": 68, "end_pos": 70 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S987-1", "uniprot_ac": "A0AAA9S987", "uniprot_id": "A0AAA9S987_BOVIN", "mass": { "chemical_mass": 43946.0, "monoisotopic_mass": 43946.0 }, "refseq": { "ac": "XP_002689205", "name": "sperm microtubule associated protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689205" }, "gene_names": [ { "name": "THEG", "type": "recommended", "evidence": [ { "id": "A0AAA9S987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987" } ] }, { "name": "THEG", "type": "synonym", "evidence": [ { "id": "XP_002689205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689205" } ] } ], "protein_names": [ { "name": "Sperm microtubule associated protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987/entry#names_and_taxonomy" } ] }, { "name": "sperm microtubule associated protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689205", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689205" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S987", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THEG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987", "locus": {} } ], "crossref": [ { "id": "A0AAA9S987", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S987", "database": "AlphaFoldDB", "categories": [] }, { "id": "788788", "url": "https://www.ncbi.nlm.nih.gov/gene/788788", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788788", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788788", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR15901", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15901", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15901:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15901:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689205", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689205", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S987", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S987-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDHQQNSFYNHHTSEAEDQPERGQDDVSLGLQGTIYENVGSKDPKFQGLDDRDLKLEDQEEEIPPEEVAGEESVDAQNPEEALLELERVLEKDVEEGVPEMRRLSISQRIPRTSTSPERKKRRRLFELAKPKTNWQILKDRMGCCCRGHAWVSPRMRSLQFCIYWPSVYWTERFLEDTTLTITVPEVSRRVEELARPKRFYSEYYNNNRTTSIWPIPRSTLEYRASNRLRELATPKVRNNIWSINMSEVSQVSRAAQMAIPSSRIIRLAKPKAPATLLEEWDPVPKPKPHVSDYNRLLHLAMPKVQSDKCVPDRDPRWEVLEVTKKAVASPRILSLAKPRVRKDLNEGYDPSHVSPAALVAQASPRLYELATPKTITKKA", "length": 381, "header": "tr|A0AAA9S987-1|A0AAA9S987_BOVIN Isoform 1 of Sperm microtubule associated protein 2 OS=Bos taurus OX=9913 GN=THEG PE=4 SV=1 CANONICAL=A0AAA9S987-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S987-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S987/entry#A0AAA9S987-1", "sequence": { "sequence": "MGDHQQNSFYNHHTSEAEDQPERGQDDVSLGLQGTIYENVGSKDPKFQGLDDRDLKLEDQEEEIPPEEVAGEESVDAQNPEEALLELERVLEKDVEEGVPEMRRLSISQRIPRTSTSPERKKRRRLFELAKPKTNWQILKDRMGCCCRGHAWVSPRMRSLQFCIYWPSVYWTERFLEDTTLTITVPEVSRRVEELARPKRFYSEYYNNNRTTSIWPIPRSTLEYRASNRLRELATPKVRNNIWSINMSEVSQVSRAAQMAIPSSRIIRLAKPKAPATLLEEWDPVPKPKPHVSDYNRLLHLAMPKVQSDKCVPDRDPRWEVLEVTKKAVASPRILSLAKPRVRKDLNEGYDPSHVSPAALVAQASPRLYELATPKTITKKA", "length": 381, "header": "tr|A0AAA9S987-1|A0AAA9S987_BOVIN Isoform 1 of Sperm microtubule associated protein 2 OS=Bos taurus OX=9913 GN=THEG PE=4 SV=1 CANONICAL=A0AAA9S987-1" }, "locus": { "chromosome": "7", "start_pos": 43077170, "end_pos": 43067110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093478.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093478.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078703.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078703.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788788", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788788", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 209, "end_pos": 211 }, { "start_pos": 246, "end_pos": 248 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9B8-1", "uniprot_ac": "A0AAA9S9B8", "uniprot_id": "A0AAA9S9B8_BOVIN", "mass": { "chemical_mass": 50562.0, "monoisotopic_mass": 50562.0 }, "refseq": { "ac": "XP_059733249", "name": "zinc finger and SCAN domain-containing protein 5B-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733249" }, "gene_names": [ { "name": "LOC532036", "type": "recommended", "evidence": [ { "id": "A0AAA9S9B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8" } ] }, { "name": "LOC532036", "type": "synonym", "evidence": [ { "id": "XP_059733249", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733249" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain containing 5B", "type": "recommended", "evidence": [ { "id": "A0AAA9S9B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and SCAN domain-containing protein 5B-like", "type": "synonym", "evidence": [ { "id": "XP_059733249", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733249" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC532036", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9B8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9B8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532036", "url": "https://www.ncbi.nlm.nih.gov/gene/532036", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532036", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532036", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059733249", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733249", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENQTRGRGPVTDSPGAESSASAPRQDTRRENPDSDLEVLRVRFRTFSSSDVSDPIKALRRLRELCGLWLRPDLHTKEQMVDRLVPEQFVKCMPPDIQVLVKSSGAETCKDLEEVLRKKQKLKKRAVVRVQGEDFLMPVSGVQMLGSEINEGHSEGDRARKPQSTVSVVPPDEGQQESQDRQHLPGAKNLSRGQGQKALPPETIPETGELEGQTPSKENLEKDLLKDTGVTRTLPSQEPELLQDREGDVSTLSGSRRGPLKNRRHVKRKRDSSPSCQDMGQEAATCLDQGEFSEQLGSRSVGSSGSVGPTSLPEGAETPGRAPSECKVCKKSFPYQSQLTLHQRTHTGERPFQCDICARGFMQLLDLQVHQRIHTGKKPYSCDICLKKFTHDFTLRAHKRTHTQEKAFRCEHCDRAFGHRGNLKVHRRTHYRIKPYVCPESQLPSVSWGL", "length": 451, "header": "tr|A0AAA9S9B8-1|A0AAA9S9B8_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC532036 PE=4 SV=1 CANONICAL=A0AAA9S9B8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8/entry#A0AAA9S9B8-1", "sequence": { "sequence": "MAENQTRGRGPVTDSPGAESSASAPRQDTRRENPDSDLEVLRVRFRTFSSSDVSDPIKALRRLRELCGLWLRPDLHTKEQMVDRLVPEQFVKCMPPDIQVLVKSSGAETCKDLEEVLRKKQKLKKRAVVRVQGEDFLMPVSGVQMLGSEINEGHSEGDRARKPQSTVSVVPPDEGQQESQDRQHLPGAKNLSRGQGQKALPPETIPETGELEGQTPSKENLEKDLLKDTGVTRTLPSQEPELLQDREGDVSTLSGSRRGPLKNRRHVKRKRDSSPSCQDMGQEAATCLDQGEFSEQLGSRSVGSSGSVGPTSLPEGAETPGRAPSECKVCKKSFPYQSQLTLHQRTHTGERPFQCDICARGFMQLLDLQVHQRIHTGKKPYSCDICLKKFTHDFTLRAHKRTHTQEKAFRCEHCDRAFGHRGNLKVHRRTHYRIKPYVCPESQLPSVSWGL", "length": 451, "header": "tr|A0AAA9S9B8-1|A0AAA9S9B8_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC532036 PE=4 SV=1 CANONICAL=A0AAA9S9B8-1" }, "locus": { "chromosome": "18", "start_pos": 63684212, "end_pos": 63681286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092405.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092405.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079990.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079990.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 311, "start_aa": "Thr", "end_pos": 311, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr311", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532036", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532036", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 325, "end_pos": 352, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9B8" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 122, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 311 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9D3-1", "uniprot_ac": "A0AAA9S9D3", "uniprot_id": "A0AAA9S9D3_BOVIN", "mass": { "chemical_mass": 141546.0, "monoisotopic_mass": 141546.0 }, "refseq": { "ac": "XP_024856643", "name": "junctional cadherin 5-associated protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856643" }, "gene_names": [ { "name": "JCAD", "type": "recommended", "evidence": [ { "id": "A0AAA9S9D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3" } ] }, { "name": "JCAD", "type": "synonym", "evidence": [ { "id": "XP_024856643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856643" } ] }, { "name": "KIAA1462", "type": "synonym", "evidence": [ { "id": "XP_024856643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856643" } ] } ], "protein_names": [ { "name": "Junctional cadherin 5 associated", "type": "synonym", "evidence": [ { "id": "A0AAA9S9D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3/entry#names_and_taxonomy" } ] }, { "name": "junctional cadherin 5-associated protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856643" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JCAD", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3", "locus": { "chromosome": "13", "start_pos": 35027792, "end_pos": 35064475, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001204", "url": "https://www.ensembl.org/id/ENSBTAG00000001204" } ] } } ], "crossref": [ { "id": "784675", "url": "https://www.ncbi.nlm.nih.gov/gene/784675", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR34757", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34757", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34757:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34757:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856643", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856643", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIE6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ACK8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ACK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ACK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYSVEDLLISHGYKLSRKLPAPHEDDGERRQPARTTVPAGPGLLNGCDDGPAALPRGKASPGTGLLSDPESRRLGPRGHGERPSTAAAARISEAGFYHQPVLAWSSQPLTGRSHAYWRRREQEAREDPGGRGPVPSLPTHPREGPWEVGGRSEHVMKKAVWEDELGMAGPARWQDVSVRSWNQPPRLGRQMSDGVGEKLFQDLYPFMLGEHGLTSQSKGKSQSLPRVLSPESLSCMEVPIPLSDGHLPGVPKVPLQPPNCASNLESTRNPKKAGTSAPLPQPRFGRPLKPPSYGSQPHSKAGAENGSYTDSRQLDPGAAHSARTNSARQDLYGPDPGLEPPVYVPPPSYKSPPQPAAHPCPEEAVSRHEGRGRRVPQHPMERPAAGGQPLSGSRGAGSEWGASPCSPVGVPPQPHHTTAYDGSILIIPFDDPRIRHIKLPRPHGFWEDVKLDGAVPAPDPRSLQQEGAVWGPSGKERGPAPADPSPSWLWGQPPRNGENGSSPDQRDPCIVTQRKQPDVSGSPQEYPESLVSSPSPQGESSCEMQTQLRKFEAGLQPKRSSKKKTSETIFCLVSIPVKSESQLPGTDTNNNDLKQSASLQEQSVLSLSSTDLELQALTGSMATRTELPRPDPGGPGRGRQADDLRFPSPAKHRALAWPGPWPGHHFRDQQTQTSFAHEPQSLQPLPGERPGGSPDPVLPPRCLDPAPFEVQMHMALASSDPNQRPGAHSPKSQGSLSPSSNSAFSGSSWPRNQGPVPRASLGQQGSDGPGRRASPVSRGEVIKGETTGPCNSRQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEGSSGSSSDGSGSEDSDTELPWGSCARPAPQLPGLLKDIVPEDPRTRPGRVKSKSESWSEEGRPRSPRPWQAEGRGSVWLSPPGSWIAEDGDREVEDRVAQLAVSPRPVKRAISSGLNDAKPEPPPDPAEQREPLPSQELPGSRGAVELSAAGPPRAGGGEQGSTRAPLSLAGKSRGLSAPDLRSVGLTLVQEHSTSQLAGSPGDANAIEIPPNESLEARAARILGIEVAVESLLPGAQRAGQRRHPEPDGSALRPESPRQEAAASLAQPNESTAPADAFYGRRKCGWTKSPLFVGERDSTRQVPRASEPADVDGAVPTKAPETPPSPLESQPFLPKDVETKPPFRSTLFHFIERTPNLAFSEKKLRNTSRVIESLQEKLVSPPRKADPDRLTRMKEVSSVSRMRLLTSRAADSAEEPKAERGPGAWLGGLVAPSAGHKLSDPQGALSLEADGHPAARRENGGRDFWCPGEESGRGAGVQVAFDVLRTSKCLVGR", "length": 1320, "header": "tr|A0AAA9S9D3-1|A0AAA9S9D3_BOVIN Isoform 1 of Junctional cadherin 5 associated OS=Bos taurus OX=9913 GN=JCAD PE=4 SV=1 CANONICAL=A0AAA9S9D3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3/entry#A0AAA9S9D3-1", "sequence": { "sequence": "MYSVEDLLISHGYKLSRKLPAPHEDDGERRQPARTTVPAGPGLLNGCDDGPAALPRGKASPGTGLLSDPESRRLGPRGHGERPSTAAAARISEAGFYHQPVLAWSSQPLTGRSHAYWRRREQEAREDPGGRGPVPSLPTHPREGPWEVGGRSEHVMKKAVWEDELGMAGPARWQDVSVRSWNQPPRLGRQMSDGVGEKLFQDLYPFMLGEHGLTSQSKGKSQSLPRVLSPESLSCMEVPIPLSDGHLPGVPKVPLQPPNCASNLESTRNPKKAGTSAPLPQPRFGRPLKPPSYGSQPHSKAGAENGSYTDSRQLDPGAAHSARTNSARQDLYGPDPGLEPPVYVPPPSYKSPPQPAAHPCPEEAVSRHEGRGRRVPQHPMERPAAGGQPLSGSRGAGSEWGASPCSPVGVPPQPHHTTAYDGSILIIPFDDPRIRHIKLPRPHGFWEDVKLDGAVPAPDPRSLQQEGAVWGPSGKERGPAPADPSPSWLWGQPPRNGENGSSPDQRDPCIVTQRKQPDVSGSPQEYPESLVSSPSPQGESSCEMQTQLRKFEAGLQPKRSSKKKTSETIFCLVSIPVKSESQLPGTDTNNNDLKQSASLQEQSVLSLSSTDLELQALTGSMATRTELPRPDPGGPGRGRQADDLRFPSPAKHRALAWPGPWPGHHFRDQQTQTSFAHEPQSLQPLPGERPGGSPDPVLPPRCLDPAPFEVQMHMALASSDPNQRPGAHSPKSQGSLSPSSNSAFSGSSWPRNQGPVPRASLGQQGSDGPGRRASPVSRGEVIKGETTGPCNSRQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEGSSGSSSDGSGSEDSDTELPWGSCARPAPQLPGLLKDIVPEDPRTRPGRVKSKSESWSEEGRPRSPRPWQAEGRGSVWLSPPGSWIAEDGDREVEDRVAQLAVSPRPVKRAISSGLNDAKPEPPPDPAEQREPLPSQELPGSRGAVELSAAGPPRAGGGEQGSTRAPLSLAGKSRGLSAPDLRSVGLTLVQEHSTSQLAGSPGDANAIEIPPNESLEARAARILGIEVAVESLLPGAQRAGQRRHPEPDGSALRPESPRQEAAASLAQPNESTAPADAFYGRRKCGWTKSPLFVGERDSTRQVPRASEPADVDGAVPTKAPETPPSPLESQPFLPKDVETKPPFRSTLFHFIERTPNLAFSEKKLRNTSRVIESLQEKLVSPPRKADPDRLTRMKEVSSVSRMRLLTSRAADSAEEPKAERGPGAWLGGLVAPSAGHKLSDPQGALSLEADGHPAARRENGGRDFWCPGEESGRGAGVQVAFDVLRTSKCLVGR", "length": 1320, "header": "tr|A0AAA9S9D3-1|A0AAA9S9D3_BOVIN Isoform 1 of Junctional cadherin 5 associated OS=Bos taurus OX=9913 GN=JCAD PE=4 SV=1 CANONICAL=A0AAA9S9D3-1" }, "locus": { "chromosome": "13", "start_pos": 35050085, "end_pos": 35034139, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121861.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121861.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080540.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080540.1" } ] } }, { "isoform_ac": "A0AAA9SB38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3/entry#A0AAA9SB38-1", "sequence": { "sequence": "MYSVEDLLISHGYKLSRKLPAPHEDDGERRQPARTTVPAGPGLLNGCDDGPAALPRGKASPGTGLLSDPESRRLGPRGHGERPSTAAAARISEAGFYHQPVLAWSSQPLTGRSHAYWRRREQEAREDPGGRGPVPSLPTHPREGPWEVGGRSEHVMKKAVWEDELGMAGPARWQDVSVRSWNQPPRLGRQMSDGVGEKLFQDLYPFMLGEHGLTSQSKGKSQSLPRVLSPESLSCMEVPIPLSDGHLPGVPKVPLQPPNCASNLESTRNPKKAGTSAPLPQPRFGRPLKPPSYGSQPHSKAGAENGSYTDSRQLDPGAAHSARTNSARQDLYGPDPGLEPPVYVPPPSYKSPPQPAAHPCPEEAVSRHEGRGRRVPQHPMERPAAGGQPLSGSRGAGSEWGASPCSPVGVPPQPHHTTAYDGSILIIPFDDPRIRHIKLPRPHGFWEDVKLDGAVPAPDPRSLQQEGAVWGPSGKERGPAPADPSPSWLWGQPPRNGENGSSPDQRDPCIVTQRKQPDVSGSPQEYPESLVSSPSPQGESSCEMQTQLRKFEAGLQPKRSSKKKTSETIFCLVSIPVKSESQLPGTDTNNNDLKQSASLQEQSVLSLSSTDLELQALTGSMATRTELPRPDPGGPGRGRQADDLRFPSPAKHRALAWPGPWPGHHFRDQQTQTSFAHEPQSLQPLPGERPGGSPDPVLPPRCLDPAPFEVQMHMALASSDPNQRPGAHSPKSQGSLSPSSNSAFSGSSWPRNQGPVPRASLGQQGSDGPGRRASPVSRGEVIKGETTGPCNSRQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEGSSGSSSDGSGSEDSDTELPWGSCARPAPQLPGLLKDIVPEDPRTRPGRVKSKSESWSEEGRPRSPRPWQAEGRGSVWLSPPGSWIAEDGDREVEDRVAQLAVSPRPVKRAISSGLNDAKPEPPPDPAEQREPLPSQELPGSRGAVELSAAGPPRAGGGEQGSTRAPLSLAGKSRGLSAPDLRSVGLTLVQEHSTSQLAGSPGDANAIEIPPNESLEARAARILGIEVAVESLLPGAQRAGQRRHPEPDGSALRPESPRQEAAASLAQPNESTAPADAFYGRRKCGWTKSPLFVGERDSTRQVPRASEPADVDGAVPTKAPETPPSPLESQPFLPKDVETKPPFRSTLFHFIERTPNLAFSEKKLRNTSRVIESLQEKLVSPPRKADPDRLTRMKEVSSVSRMRLLTSRAADSAEEPKAERGPGAWLGGLVAPSAGHKLSDPQGALSLEADGHPAARRENGGRDFWCPDNRHSPR", "length": 1301, "header": "tr|A0AAA9SB38-1|A0AAA9SB38_BOVIN Computationally mapped isoform of Junctional cadherin 5 associated OS=Bos taurus OX=9913 GN=JCAD PE=4 SV=1 CANONICAL=A0AAA9S9D3-1" }, "locus": { "chromosome": "13", "start_pos": 35050085, "end_pos": 35033819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126236.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126236.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081114.1" } ] } }, { "isoform_ac": "A0AAF6YIE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3/entry#A0AAF6YIE6-1", "sequence": { "sequence": "MYSVEDLLISHGYKLSRKLPAPHEDDGERRQPARTTVPAGPGLLNGCDDGPAALPRGKASPGTGLLSDPESRRLGPRGHGERPSTAAAARISEAGFYHQPVLAWSSQPLTGRSHAYWRRREQEAREDPGGRGPVPSLPTHPREGPWEVGGRSEHVMKKAVWEDELGMAGPARWQDVSVRSWNQPPRLGRQMSDGVGEKLFQDLYPFMLGEHGLTSQSKGKSQSLPRVLSPESLSCMEVPIPLSDGHLPGVPKVPLQPPNCASNLESTRNPKKAGTSAPLPQPRFGRPLKPPSYGSQPHSKAGAENGSYTDSRQLDPGAAHSARTNSARQDLYGPDPGLEPPVYVPPPSYKSPPQPAAHPCPEEAVSRHEGRGRRVPQHPMERPAAGGQPLSGSRGAGSEWGASPCSPVGVPPQPHHTTAYDGSILIIPFDDPRIRHIKLPRPHGFWEDVKLDGAVPAPDPRSLQQEGAVWGPSGKERGPAPADPSPSWLWGQPPRNGENGSSPDQRDPCIVTQRKQPDVSGSPQEYPESLVSSPSPQGESSCEMQTQLRKFEAGLQPKRSSKKKTSETIFCLVSIPVKSESQLPGTDTNNNDLKQSASLQEQSVLSLSSTDLELQALTGSMATRTELPRPDPGGPGRGRQADDLRFPSPAKHRALAWPGPWPGHHFRDQQTQTSFAHEPQSLQPLPGERPGGSPDPVLPPRCLDPAPFEVQMHMALASSDPNQRPGAHSPKSQGSLSPSSNSAFSGSSWPRNQGPVPRASLGQQGSDGPGRRASPVSRGEVIKGETTGPCNSRQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEGSSGSSSDGSGSEDSDTELPWGSCARPAPQLPGLLKDIVPEDPRTRPGRVKSKSESWSEEGRPRSPRPWQAEGRGSVWLSPPGSWIAEDGDREVEDRVAQLAVSPRPVKRAISSGLNDAKPEPPPDPAEQREPLPSQELPGSRGAVELSAAGPPRAGGGEQGSTRAPLSLAGKSRGLSAPDLRSVGLTLVQEHSTSQLAGSPGDANAIEIPPNESLEARAARILGIEVAVESLLPGAQRAGQRRHPEPDGSALRPESPRQEAAASLAQPNESTAPADAFYGRRKCGWTKSPLFVGERDSTRQVPRASEPADVDGAVPTKAPETPPSPLESQPFLPKDVETKPPFRSTLFHFIERTPNLAFSEKKLRNTSRVIESLQEKLVSPPRKADPDRLTRMKEIPMTQAGWRGCDGTPLECGAASFADG", "length": 1248, "header": "tr|A0AAF6YIE6-1|A0AAF6YIE6_BOVIN Computationally mapped isoform of Junctional cadherin 5 associated OS=Bos taurus OX=9913 GN=JCAD PE=4 SV=1 CANONICAL=A0AAA9S9D3-1" }, "locus": { "chromosome": "13", "start_pos": 35050085, "end_pos": 35028785, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001595.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001595.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001595.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001595.6" } ] } }, { "isoform_ac": "A0AAF7ACK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3/entry#A0AAF7ACK8-1", "sequence": { "sequence": "MYSVEDLLISHGYKLSRKLPAPHEDDGERRQPARTTVPAGPGLLNGCDDGPAALPRGKASPGTGLLSDPESRRLGPRGHGERPSTAAAARISEAGFYHQPVLAWSSQPLTGRSHAYWRRREQEAREDPGGRGPVPSLPTHPREGPWEVGGRSEHVMKKAVWEDELGMAGPARWQDVSVRSWNQPPRLGRQMSDGVGEKLFQDLYPFMLGEHGLTSQSKGKSQSLPRVLSPESLSCMEVPIPLSDGHLPGVPKVPLQPPNCASNLESTRNPKKAGTSAPLPQPRFGRPLKPPSYGSQPHSKAGAENGSYTDSRQLDPGAAHSARTNSARQDLYGPDPGLEPPVYVPPPSYKSPPQPAAHPCPEEAVSRHEGRGRRVPQHPMERPAAGGQPLSGSRGAGSEWGASPCSPVGVPPQPHHTTAYDGSILIIPFDDPRIRHIKLPRPHGFWEDVKLDGAVPAPDPRSLQQEGAVWGPSGKERGPAPADPSPSWLWGQPPRNGENGSSPDQRDPCIVTQRKQPDVSGSPQEYPESLVSSPSPQGESSCEMQTQLRKFEAGLQPKRSSKKKTSETIFCLVSIPVKSESQLPGTDTNNNDLKQSASLQEQSVLSLSSTDLELQALTGSMATRTELPRPDPGGPGRGRQADDLRFPSPAKHRALAWPGPWPGHHFRDQQTQTSFAHEPQSLQPLPGERPGGSPDPVLPPRCLDPAPFEVQMHMALASSDPNQRPGAHSPKSQGSLSPSSNSAFSGSSWPRNQGPVPRASLGQQGSDGPGRRASPVSRGEVIKGETTGPCNSRQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEGSSGSSSDGSGSEDSDTELPWGSCARPAPQLPGLLKDIVPEDPRTRPGRVKSKSESWSEEGRPRSPRPWQAEGRGSVWLSPPGSWIAEDGDREVEDRVAQLAVSPRPVKRAISSGLNDAKPEPPPDPAEQREPLPSQELPGSRGAVELSAAGPPRAGGGEQGSTRAPLSLAGKSRGLSAPDLRSVGLTLVQEHSTSQLAGSPGDANAIEIPPNESLEARAARILGIEVAVESLLPGAQRAGQRRHPEPDGSALRPESPRQEAAASLAQPNESTAPADAFYGRRKCGWTKSPLFVGERDSTRQVPRASEPADVDGAVPTKAPETPPSPLESQPFLPKDVETKPPFRSTLFHFIERTPNLAFSEKKLRNTSRVIESLQEKLVSPPRKADPDRLTRMKEVSSVSRMRLLTSRAADSAEEPKAERGPGAWLGGLVAPSAGHKLSDPQGALSLEADGHPAARRENGGRDFWCPAMPARV", "length": 1300, "header": "tr|A0AAF7ACK8-1|A0AAF7ACK8_BOVIN Computationally mapped isoform of Junctional cadherin 5 associated OS=Bos taurus OX=9913 GN=JCAD PE=4 SV=1 CANONICAL=A0AAA9S9D3-1" }, "locus": { "chromosome": "13", "start_pos": 35050085, "end_pos": 35033898, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066527.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066527.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1096, "end_pos": 1098, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1193, "end_pos": 1195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 499, "end_pos": 501, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 1096, "end_pos": 1098 }, { "start_pos": 1193, "end_pos": 1195 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 499, "end_pos": 501 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9E6-1", "uniprot_ac": "A0AAA9S9E6", "uniprot_id": "A0AAA9S9E6_BOVIN", "mass": { "chemical_mass": 15824.0, "monoisotopic_mass": 15824.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Core Histone H2A/H2B/H3 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9S9E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9E6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9E6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22910", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22910", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPEPAKSPPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPHTGISSKAMGIMNSFVNDIFESIAGEASRLAHYNKCSTITSREIQTTVSLLLPGELAKHAVSKGTKAVTKYTSSRNEKTGNSLHSTPGLLPWGN", "length": 145, "header": "tr|A0AAA9S9E6-1|A0AAA9S9E6_BOVIN Isoform 1 of Core Histone H2A/H2B/H3 domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S9E6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6/entry#A0AAA9S9E6-1", "sequence": { "sequence": "MPEPAKSPPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPHTGISSKAMGIMNSFVNDIFESIAGEASRLAHYNKCSTITSREIQTTVSLLLPGELAKHAVSKGTKAVTKYTSSRNEKTGNSLHSTPGLLPWGN", "length": 145, "header": "tr|A0AAA9S9E6-1|A0AAA9S9E6_BOVIN Isoform 1 of Core Histone H2A/H2B/H3 domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S9E6-1" }, "locus": { "chromosome": "20", "start_pos": 31159617, "end_pos": 31111292, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093596.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093596.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080028.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080028.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9E6" }, { "id": "PF00125", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Core Histone H2A/H2B/H3", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 99, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9F1-1", "uniprot_ac": "A0AAA9S9F1", "uniprot_id": "A0AAA9S9F1_BOVIN", "mass": { "chemical_mass": 27151.0, "monoisotopic_mass": 27151.0 }, "refseq": { "ac": "XP_024855140", "name": "protein YIPF4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855140" }, "gene_names": [ { "name": "YIPF4", "type": "recommended", "evidence": [ { "id": "A0AAA9S9F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ] }, { "name": "YIPF4", "type": "synonym", "evidence": [ { "id": "XP_024855140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855140" } ] } ], "protein_names": [ { "name": "Protein YIPF", "type": "recommended", "evidence": [ { "id": "A0AAA9S9F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1/entry#names_and_taxonomy" } ] }, { "name": "protein YIPF4", "type": "synonym", "evidence": [ { "id": "XP_024855140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855140" } ] } ], "function": [ { "annotation": "Involved in the maintenance of the Golgi structure.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1#function" }, { "database": "UniProtKB", "id": "ARBA00037720", "url": "https://www.uniprot.org/uniprotkb/ARBA00037720#function" }, { "database": "UniProtKB", "id": "F1MHD7", "url": "https://www.uniprot.org/uniprotkb/F1MHD7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YIPF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1", "locus": { "chromosome": "11", "start_pos": 14919173, "end_pos": 14885108, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033041", "url": "https://www.ensembl.org/id/ENSBTAG00000033041" } ] } } ], "crossref": [ { "id": "A0AAA9S9F1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9F1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033041", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033041", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615287", "url": "https://www.ncbi.nlm.nih.gov/gene/615287", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615287", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615287", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SWIITMW", "url": "https://omabrowser.org/oma/group/SWIITMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MHD7", "url": "https://www.orthodb.org/?gene=F1MHD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21236:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21236:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024855140", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855140", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9F1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHD7", "url": "https://www.uniprot.org/uniprotkb/F1MHD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHD7-1", "url": "https://www.uniprot.org/uniprotkb/F1MHD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPPGPPPAYTPTNGDFTFVSSADAEELSGSIAPPDVKLNLGGDFIKESTATTFLRQRGYGWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPILLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 244, "header": "tr|A0AAA9S9F1-1|A0AAA9S9F1_BOVIN Isoform 1 of Protein YIPF OS=Bos taurus OX=9913 GN=YIPF4 PE=3 SV=1 CANONICAL=A0AAA9S9F1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9F1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1/entry#A0AAA9S9F1-1", "sequence": { "sequence": "MQPPGPPPAYTPTNGDFTFVSSADAEELSGSIAPPDVKLNLGGDFIKESTATTFLRQRGYGWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPILLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 244, "header": "tr|A0AAA9S9F1-1|A0AAA9S9F1_BOVIN Isoform 1 of Protein YIPF OS=Bos taurus OX=9913 GN=YIPF4 PE=3 SV=1 CANONICAL=A0AAA9S9F1-1" }, "locus": { "chromosome": "11", "start_pos": 14918169, "end_pos": 14885307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129136.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129136.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080033.1" } ] } }, { "isoform_ac": "F1MHD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1/entry#F1MHD7-1", "sequence": { "sequence": "MRFNFSKELSGSIAPPDVKLNLGGDFIKESTATTFLRQRGYGWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPILLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 225, "header": "tr|F1MHD7-1|F1MHD7_BOVIN Computationally mapped isoform of Protein YIPF OS=Bos taurus OX=9913 GN=YIPF4 PE=3 SV=4 CANONICAL=A0AAA9S9F1-1" }, "locus": { "chromosome": "11", "start_pos": 14918169, "end_pos": 14897444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010857.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010857.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010857.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010857.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615287", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615287", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5M7T4-1", "protein_name": "Protein YIPF4", "gene_name": "Yipf4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQPPGPPPAYAPANGDFTFVSSADAEDLSGSIAAPDVKLNLGVSGDFIKESTATTFLRQRGYGWLLEVEDEDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPILLVVGSFEMVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 246 }, "evidence": [ { "id": "A0AAA9S9F1", "url": "https://omabrowser.org/oma/group/A0AAA9S9F1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZJD7-1", "protein_name": "Protein YIPF4", "gene_name": "YIPF4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQPPGPQQPPPPPLFTPNNGDFTFVSSADAEDPSGSITTPDVKLNLGGEFIKESSATTFLRQRGYGWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFKVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPVLLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 249 }, "evidence": [ { "id": "A0AAA9S9F1", "url": "https://omabrowser.org/oma/group/A0AAA9S9F1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6NYF1-1", "protein_name": "Protein YIPF4", "gene_name": "yipf4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQFSPTNGDFTFVSSTDAEELSGTIDAPDITLNMGPESNRDTYATTFLRQRGYGWLLEVEEEESEDTKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLLFSMISIYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVSYGQVLGVIGYSLLPLIVIAPLLLVIGGFEVVSTLIKLFGVFWAAYSAASLLVGDEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 237 }, "evidence": [ { "id": "A0AAA9S9F1", "url": "https://omabrowser.org/oma/group/A0AAA9S9F1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8C407-1", "protein_name": "Protein YIPF4", "gene_name": "Yipf4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQPPGPPPAYAPANGDFTFVSSADAEDLSGSIAAPDVKLNLGVSGDFIKESTATTFLRQRGYGWLLEVEDEDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPILLVVGSFEMVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 246 }, "evidence": [ { "id": "A0AAA9S9F1", "url": "https://omabrowser.org/oma/group/A0AAA9S9F1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BSR8-1", "protein_name": "Protein YIPF4", "gene_name": "YIPF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQPPGPPPAYAPTNGDFTFVSSADAEDLSGSIASPDVKLNLGGDFIKESTATTFLRQRGYGWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLAVVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIVIAPVLLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSLYTGV", "length": 244 }, "evidence": [ { "id": "A0AAA9S9F1", "url": "https://omabrowser.org/oma/group/A0AAA9S9F1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ], "pmid": "" }, { "name": "vesicle fusion with Golgi apparatus", "id": "GO:0048280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048280", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F1" }, { "id": "PF04893", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Yip1", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 239, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9J9-1", "uniprot_ac": "A0AAA9S9J9", "uniprot_id": "A0AAA9S9J9_BOVIN", "mass": { "chemical_mass": 112497.0, "monoisotopic_mass": 112497.0 }, "refseq": {}, "gene_names": [ { "name": "C25H16orf96", "type": "recommended", "evidence": [ { "id": "A0AAA9S9J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9" } ] } ], "protein_names": [ { "name": "Chromosome 16 open reading frame 96", "type": "synonym", "evidence": [ { "id": "A0AAA9S9J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C25H16orf96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9J9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9J9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR032013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47080", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47080", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47080:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47080:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16043", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16043", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9J9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFSLKFSELVNIAIPQCGVVNFKALHFLLHGILEHIHMAELEKDLSGDEDFLQASVSVTFPSREGDAQPTLSPLKRLGNIFDHLVSRVDMLESQLAALRDMPSTAQLVESSQGTRQPAQELWNLIRLRKKVEGNEEAVAKSIRTLQDLLTDIYALKVSVETLGKEVAMLKDVFEKVDPPQIDAFSEDLRGQNRKMSALQREVTSLQSKVTAIPKPEDLVLWSSLHEAMFIPVSEGYSELWQIAELASETAVAQTAEDRGGGRPSHFSEAIQHPRFLETVWQYQAPGQLLEEEPAQAALLLGAEGPDQPQVPEPAPGPGPVLGPRPAPGPGPSPGPGPAPGPGPLSGPGPVFGPRPAPGPGPAFGPGPAPELEPALGLQPTPSGSWTVPPQGWPPPRGFPGTSPGPFWGFQPGLRPMGFPPLGSAWPRSQQSMYYPGDMSKLSALSEKEEESSSVEREGPRDRALRAEVPPGGLPKGFRSAVQQMKPSAALMAAAAASYTSDVATSAARAAKATAKLIRDAPATKLATVATAAATAGPLGVLAEFLGAGPSRGAFSGAEVEDLLEVEDEDLLSPAYSSVFVSPDTALSQAMLAAKHATTPEDKKKAVRYSMSHIAQMPVRHDTLKEEFAQLSSNLQQRMTYLANMGASSKLGSTLDILQEKIGNLQKSRMKEEELERVWGHQIEMIKDHHIVLDRAVNRLQIRLDELKVVYAQLRNLEMYKADRNEMEQELKEKADKSSLAGKASRADLDTVAMQLNEMIQGMLFRVVASEDDWKKAVEHLDKDVRTKLVPSDLDDLKKDMDEVWKVVRKLLIEGFHFDPDNAAGFRRKLFERVKCISCNRPVEMMTSPQLITIRNTHLLPWLRPASANSYEYLQRQQMREQQQLQKLQNLGVPERSLDSLGTPQDWGDCPRNDTNLEFKPYGLSTVYPYGDPELLDYDSAEVDLLGVDGILYKGRMTSKDKTRPLTSAEKELAAPALGQEHPKGHLLCAFEVPLSGKRGSTHCPSGVRPGATESRLWCPPSPHLPPLT", "length": 1029, "header": "tr|A0AAA9S9J9-1|A0AAA9S9J9_BOVIN Isoform 1 of Chromosome 16 open reading frame 96 OS=Bos taurus OX=9913 GN=C25H16orf96 PE=4 SV=1 CANONICAL=A0AAA9S9J9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9J9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9/entry#A0AAA9S9J9-1", "sequence": { "sequence": "MSFSLKFSELVNIAIPQCGVVNFKALHFLLHGILEHIHMAELEKDLSGDEDFLQASVSVTFPSREGDAQPTLSPLKRLGNIFDHLVSRVDMLESQLAALRDMPSTAQLVESSQGTRQPAQELWNLIRLRKKVEGNEEAVAKSIRTLQDLLTDIYALKVSVETLGKEVAMLKDVFEKVDPPQIDAFSEDLRGQNRKMSALQREVTSLQSKVTAIPKPEDLVLWSSLHEAMFIPVSEGYSELWQIAELASETAVAQTAEDRGGGRPSHFSEAIQHPRFLETVWQYQAPGQLLEEEPAQAALLLGAEGPDQPQVPEPAPGPGPVLGPRPAPGPGPSPGPGPAPGPGPLSGPGPVFGPRPAPGPGPAFGPGPAPELEPALGLQPTPSGSWTVPPQGWPPPRGFPGTSPGPFWGFQPGLRPMGFPPLGSAWPRSQQSMYYPGDMSKLSALSEKEEESSSVEREGPRDRALRAEVPPGGLPKGFRSAVQQMKPSAALMAAAAASYTSDVATSAARAAKATAKLIRDAPATKLATVATAAATAGPLGVLAEFLGAGPSRGAFSGAEVEDLLEVEDEDLLSPAYSSVFVSPDTALSQAMLAAKHATTPEDKKKAVRYSMSHIAQMPVRHDTLKEEFAQLSSNLQQRMTYLANMGASSKLGSTLDILQEKIGNLQKSRMKEEELERVWGHQIEMIKDHHIVLDRAVNRLQIRLDELKVVYAQLRNLEMYKADRNEMEQELKEKADKSSLAGKASRADLDTVAMQLNEMIQGMLFRVVASEDDWKKAVEHLDKDVRTKLVPSDLDDLKKDMDEVWKVVRKLLIEGFHFDPDNAAGFRRKLFERVKCISCNRPVEMMTSPQLITIRNTHLLPWLRPASANSYEYLQRQQMREQQQLQKLQNLGVPERSLDSLGTPQDWGDCPRNDTNLEFKPYGLSTVYPYGDPELLDYDSAEVDLLGVDGILYKGRMTSKDKTRPLTSAEKELAAPALGQEHPKGHLLCAFEVPLSGKRGSTHCPSGVRPGATESRLWCPPSPHLPPLT", "length": 1029, "header": "tr|A0AAA9S9J9-1|A0AAA9S9J9_BOVIN Isoform 1 of Chromosome 16 open reading frame 96 OS=Bos taurus OX=9913 GN=C25H16orf96 PE=4 SV=1 CANONICAL=A0AAA9S9J9-1" }, "locus": { "chromosome": "25", "start_pos": 3732348, "end_pos": 3702039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080605.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 381, "start_aa": "Thr", "end_pos": 381, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr381", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 913, "end_pos": 915, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J9" }, { "id": "PF16043", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4795", "eco_id": "ECO_0000259", "start_pos": 692, "end_pos": 863, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 381 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 913, "end_pos": 915 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9K5-1", "uniprot_ac": "A0AAA9S9K5", "uniprot_id": "A0AAA9S9K5_BOVIN", "mass": { "chemical_mass": 35546.0, "monoisotopic_mass": 35546.0 }, "refseq": { "ac": "NP_001377213", "name": "olfactory receptor family 8 subfamily G member 3F", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213" }, "gene_names": [ { "name": "OR8G3F", "type": "recommended", "evidence": [ { "id": "A0AAA9S9K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5" } ] }, { "name": "OR8G3F", "type": "synonym", "evidence": [ { "id": "NP_001377213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S9K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 8G2", "type": "synonym", "evidence": [ { "id": "NP_001377213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213" } ] }, { "name": "olfactory receptor family 8 subfamily G member 3F", "type": "synonym", "evidence": [ { "id": "NP_001377213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213" } ] }, { "name": "putative olfactory receptor 8G3-like 2", "type": "synonym", "evidence": [ { "id": "NP_001377213", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8G3F", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5", "locus": { "chromosome": "29", "start_pos": 27261271, "end_pos": 27260318, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000067517", "url": "https://www.ensembl.org/id/ENSBTAG00000067517" } ] } } ], "crossref": [ { "id": "A0AAA9S9K5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9K5", "database": "AlphaFoldDB", "categories": [] }, { "id": "781277", "url": "https://www.ncbi.nlm.nih.gov/gene/781277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781277", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377213", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPGNHSSVTEFILAGLTEQPQLQLPLFLLFLGIYVVTMVGNLGMITLTGLSSHLHTPMYYFLTNLSFIDLCQSTVITPKMLVSFVTEKNIISYPECMTQLYFFIIFAISESHMLAVMAYDRYVAICNPLLYNITMSYYICFCLTVGVYILGITGSTVHTGFMLRLFFCNTNIINHYFCDLFPLLELSCSSIYVNELLVIFLSAFNILIPALVILSSYIFIISSILQIHSKEGRSKAFSTCSSHISAVAIFYGSTAFMYLQPSSVSSMDQGKVSSVFYTIIVPMLNPLIYSLRNRDVKFALKKILDCAKHVGTEPIS", "length": 317, "header": "tr|A0AAA9S9K5-1|A0AAA9S9K5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G3F PE=3 SV=1 CANONICAL=A0AAA9S9K5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5/entry#A0AAA9S9K5-1", "sequence": { "sequence": "MDPGNHSSVTEFILAGLTEQPQLQLPLFLLFLGIYVVTMVGNLGMITLTGLSSHLHTPMYYFLTNLSFIDLCQSTVITPKMLVSFVTEKNIISYPECMTQLYFFIIFAISESHMLAVMAYDRYVAICNPLLYNITMSYYICFCLTVGVYILGITGSTVHTGFMLRLFFCNTNIINHYFCDLFPLLELSCSSIYVNELLVIFLSAFNILIPALVILSSYIFIISSILQIHSKEGRSKAFSTCSSHISAVAIFYGSTAFMYLQPSSVSSMDQGKVSSVFYTIIVPMLNPLIYSLRNRDVKFALKKILDCAKHVGTEPIS", "length": 317, "header": "tr|A0AAA9S9K5-1|A0AAA9S9K5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G3F PE=3 SV=1 CANONICAL=A0AAA9S9K5-1" }, "locus": { "chromosome": "29", "start_pos": 27261268, "end_pos": 27260318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099554.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099554.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080091.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080091.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781277", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781277", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9L4-1", "uniprot_ac": "A0AAA9S9L4", "uniprot_id": "A0AAA9S9L4_BOVIN", "mass": { "chemical_mass": 48082.0, "monoisotopic_mass": 48082.0 }, "refseq": {}, "gene_names": [ { "name": "AADAT", "type": "recommended", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] } ], "protein_names": [ { "name": "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2-aminoadipate aminotransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2-aminoadipate transaminase", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.39", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.4", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.63", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.73", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.7", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Alpha-aminoadipate aminotransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Glycine transaminase AADAT", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine aminotransferase II", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine--glyoxylate transaminase AADAT", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine--oxoglutarate aminotransferase II", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine--oxoglutarate transaminase 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Kynurenine--oxoglutarate transaminase II", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] }, { "name": "Methionine--glyoxylate transaminase AADAT", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4#function" }, { "database": "UniProtKB", "id": "ARBA00056991", "url": "https://www.uniprot.org/uniprotkb/ARBA00056991#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9L4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9L4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010326", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010326", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MKS7", "url": "https://www.orthodb.org/?gene=F1MKS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42790", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42790", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42790:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42790:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00155", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "14089", "url": "https://www.rhea-db.org/rhea/14089", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22884", "url": "https://www.rhea-db.org/rhea/22884", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "65560", "url": "https://www.rhea-db.org/rhea/65560", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "65896", "url": "https://www.rhea-db.org/rhea/65896", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66044", "url": "https://www.rhea-db.org/rhea/66044", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66052", "url": "https://www.rhea-db.org/rhea/66052", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66060", "url": "https://www.rhea-db.org/rhea/66060", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66068", "url": "https://www.rhea-db.org/rhea/66068", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66076", "url": "https://www.rhea-db.org/rhea/66076", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66092", "url": "https://www.rhea-db.org/rhea/66092", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69096", "url": "https://www.rhea-db.org/rhea/69096", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69104", "url": "https://www.rhea-db.org/rhea/69104", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69112", "url": "https://www.rhea-db.org/rhea/69112", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69116", "url": "https://www.rhea-db.org/rhea/69116", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69120", "url": "https://www.rhea-db.org/rhea/69120", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69124", "url": "https://www.rhea-db.org/rhea/69124", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69128", "url": "https://www.rhea-db.org/rhea/69128", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70047", "url": "https://www.rhea-db.org/rhea/70047", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKS7", "url": "https://www.uniprot.org/uniprotkb/F1MKS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKS7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNYTRFITAKSAARKPYSIRVMYEKLDKAPKSVISLATGVPNPNMFPFKTAVITIENGKAIQFDEELMKKALQYSQSAGLPELLSWLKQLQVKLHNPPTIHYAPSQGQMDLCVTCGSLEGLYKVFEMIVNPGDNILVNEPVYSGTIHALQPLGCNMINVSSDEHGIIPDSLREILSKWKPEDSKDPEKNSPKCLYTVPNGNNPSGNSLTAERKREIYELARKYDFLIIEDDPYYFMQFNKPWAPTFLSMDVDGRVIRADSFSKVLSSGLRVGFITGPKPLIERIVLHIQVSTLHTSTFTQLLVSQLLHQWGEEGFLTHIDRVTDFYRKQRDALLAAADKWLSGLAEWQVPTAGMFLWVKIKGIHDVRKLIEEKAVKNEIFMLPGYGFYIDSSAPCPYFRASFSSASPEQMDMAFQRLAQLIEESL", "length": 425, "header": "tr|A0AAA9S9L4-1|A0AAA9S9L4_BOVIN Isoform 1 of Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S9L4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#A0AAA9S9L4-1", "sequence": { "sequence": "MNYTRFITAKSAARKPYSIRVMYEKLDKAPKSVISLATGVPNPNMFPFKTAVITIENGKAIQFDEELMKKALQYSQSAGLPELLSWLKQLQVKLHNPPTIHYAPSQGQMDLCVTCGSLEGLYKVFEMIVNPGDNILVNEPVYSGTIHALQPLGCNMINVSSDEHGIIPDSLREILSKWKPEDSKDPEKNSPKCLYTVPNGNNPSGNSLTAERKREIYELARKYDFLIIEDDPYYFMQFNKPWAPTFLSMDVDGRVIRADSFSKVLSSGLRVGFITGPKPLIERIVLHIQVSTLHTSTFTQLLVSQLLHQWGEEGFLTHIDRVTDFYRKQRDALLAAADKWLSGLAEWQVPTAGMFLWVKIKGIHDVRKLIEEKAVKNEIFMLPGYGFYIDSSAPCPYFRASFSSASPEQMDMAFQRLAQLIEESL", "length": 425, "header": "tr|A0AAA9S9L4-1|A0AAA9S9L4_BOVIN Isoform 1 of Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9S9L4-1" }, "locus": { "chromosome": "8", "start_pos": 2000436, "end_pos": 1963625, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113582.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113582.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078834.1" } ] } }, { "isoform_ac": "F1MKS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4/entry#F1MKS7-1", "sequence": { "sequence": "MNYTRFITAKSAARKPYSIRVMYEKLDKAPKSVISLATGVPNPNMFPFKTAVITIENGKAIQFDEELMKKALQYSQSAGLPELLSWLKQLQVKLHNPPTIHYAPSQGQMDLCVTCGSLEGLYKVFEMIVNPGDNILVNEPVYSGTIHALQPLGCNMINVSSDEHGIIPDSLREILSKWKPEDSKDPEKNSPKCLYTVPNGNNPSGNSLTAERKREIYELARKYDFLIIEDDPYYFMQFNKPWAPTFLSMDVDGRVIRADSFSKVLLQIKVTGLPLSIFSLLVSQLLHQWGEEGFLTHIDRVTDFYRKQRDALLAAADKWLSGLAEWQVPTAGMFLWVKIKGIHDVRKLIEEKAVKNEIFMLPGYGFYIDSSAPCPYFRASFSSASPEQMDMVNGVFLGVFLIYLLSHIIKYALH", "length": 414, "header": "tr|F1MKS7-1|F1MKS7_BOVIN Computationally mapped isoform of Aminoadipate aminotransferase OS=Bos taurus OX=9913 GN=AADAT PE=3 SV=3 CANONICAL=A0AAA9S9L4-1" }, "locus": { "chromosome": "8", "start_pos": 2000436, "end_pos": 1964203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013637.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013637.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013637.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013637.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "kynurenine-glyoxylate transaminase activity", "id": "GO:0047315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" }, { "name": "kynurenine-oxoglutarate transaminase activity", "id": "GO:0016212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" }, { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" }, { "name": "2-aminoadipate transaminase activity", "id": "GO:0047536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047536", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" }, { "name": "glycine:2-oxoglutarate aminotransferase activity", "id": "GO:0047958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047958", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" }, { "name": "methionine-glyoxylate transaminase activity", "id": "GO:0050094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "alpha-amino acid metabolic process", "id": "GO:1901605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14089", "name": "", "equation": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "14089", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14089" } ] }, { "id": "22884", "name": "", "equation": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "22884", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22884" } ] }, { "id": "65560", "name": "", "equation": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TKC4-1", "A0AAF6YGX9-1", "Q5E9N4-1", "Q0P5G4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1", "A0AAA9S197-1" ], "evidence": [ { "id": "65560", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65560" } ] }, { "id": "65896", "name": "", "equation": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YGX9-1", "Q5E9N4-1", "Q0P5G4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "65896", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65896" } ] }, { "id": "66044", "name": "", "equation": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "66044", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66044" } ] }, { "id": "66052", "name": "", "equation": "indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "66052", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66052" } ] }, { "id": "66060", "name": "", "equation": "2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "66060", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66060" } ] }, { "id": "66068", "name": "", "equation": "4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "66068", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66068" } ] }, { "id": "66076", "name": "", "equation": "2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "66076", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66076" } ] }, { "id": "66092", "name": "", "equation": "3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "66092", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66092" } ] }, { "id": "69096", "name": "", "equation": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69096", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69096" } ] }, { "id": "69104", "name": "", "equation": "2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69104", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69104" } ] }, { "id": "69112", "name": "", "equation": "L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69112", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69112" } ] }, { "id": "69116", "name": "", "equation": "L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69116", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69116" } ] }, { "id": "69120", "name": "", "equation": "glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69120", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69120" } ] }, { "id": "69124", "name": "", "equation": "L-tryptophan + glyoxylate = indole-3-pyruvate + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69124", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69124" } ] }, { "id": "69128", "name": "", "equation": "L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "69128", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69128" } ] }, { "id": "70047", "name": "", "equation": "2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9N4-1", "A0AAA9S9L4-1", "A0A3Q1LKR3-1" ], "evidence": [ { "id": "70047", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70047" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LKR3", "gene_name": "AADAT", "activity": [ { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.39", "activity": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.4", "activity": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.73", "activity": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.63", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.73", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.39", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0A3Q1LKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKR3" } ] } ] }, { "uniprot_ac": "A0AAA9S197", "gene_name": "LOC104968656", "activity": [ { "ec_number": "2.6.1.64", "activity": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "4.4.1.13", "activity": "", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] }, { "ec_number": "2.6.1.64", "activity": "", "evidence": [ { "id": "A0AAA9S197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S197" } ] } ] }, { "uniprot_ac": "A0AAA9S9L4", "gene_name": "", "activity": [ { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.39", "activity": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.4", "activity": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.73", "activity": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.39", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.63", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.73", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.4", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" } ] } ] }, { "uniprot_ac": "A0AAA9TKC4", "gene_name": "KYAT1", "activity": [ { "ec_number": "2.6.1.64", "activity": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine.", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "2.6.1.64", "activity": "", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] }, { "ec_number": "4.4.1.13", "activity": "", "evidence": [ { "id": "A0AAA9TKC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC4" } ] } ] }, { "uniprot_ac": "A0AAF6YGX9", "gene_name": "", "activity": [ { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "2.6.1.63", "activity": "", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] }, { "ec_number": "4.4.1.13", "activity": "", "evidence": [ { "id": "A0AAF6YGX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGX9" } ] } ] }, { "uniprot_ac": "Q0P5G4", "gene_name": "KYAT3", "activity": [ { "ec_number": "4.4.1.13", "activity": "an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+).", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] }, { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] }, { "ec_number": "2.6.1.7", "activity": "", "evidence": [ { "id": "Q0P5G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5G4" } ] } ] }, { "uniprot_ac": "Q5E9N4", "gene_name": "AADAT", "activity": [ { "ec_number": "2.6.1.63", "activity": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.39", "activity": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.7", "activity": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.4", "activity": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] }, { "ec_number": "2.6.1.73", "activity": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "Q5E9N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L4" }, { "id": "PF00155", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminotransferase class I/classII large", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 417, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.6.1.63", "ec_name": "L-kynurenine + glyoxylate = kynurenate + glycine + H2O.", "evidence": [ { "id": "2.6.1.63", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63" } ] }, { "ec_number": "2.6.1.39", "ec_name": "L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.", "evidence": [ { "id": "2.6.1.39", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39" }, { "id": "2.6.1.39", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.39" } ] }, { "ec_number": "2.6.1.7", "ec_name": "L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O.", "evidence": [ { "id": "2.6.1.7", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7" }, { "id": "2.6.1.7", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.7" } ] }, { "ec_number": "2.6.1.4", "ec_name": "glycine + 2-oxoglutarate = glyoxylate + L-glutamate.", "evidence": [ { "id": "2.6.1.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4" }, { "id": "2.6.1.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.4" } ] }, { "ec_number": "2.6.1.73", "ec_name": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine.", "evidence": [ { "id": "2.6.1.73", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9L5-1", "uniprot_ac": "A0AAA9S9L5", "uniprot_id": "A0AAA9S9L5_BOVIN", "mass": { "chemical_mass": 11216.0, "monoisotopic_mass": 11216.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Serine peptidase inhibitor Kazal type 14 (putative)", "type": "synonym", "evidence": [ { "id": "A0AAA9S9L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9L5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9L5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47499:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47499:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00050", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00050", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIPFEVLCSQLFFIPIYLALPSVSGPPRWWLPHGNIKVKCPYKKVDFSWFQGTVNPCPGLYQPICGNNLITYDDPCILCVESMKSQGKIRLLHDGQCE", "length": 99, "header": "tr|A0AAA9S9L5-1|A0AAA9S9L5_BOVIN Isoform 1 of Serine peptidase inhibitor Kazal type 14 (putative) OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S9L5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5/entry#A0AAA9S9L5-1", "sequence": { "sequence": "MAIPFEVLCSQLFFIPIYLALPSVSGPPRWWLPHGNIKVKCPYKKVDFSWFQGTVNPCPGLYQPICGNNLITYDDPCILCVESMKSQGKIRLLHDGQCE", "length": 99, "header": "tr|A0AAA9S9L5-1|A0AAA9S9L5_BOVIN Isoform 1 of Serine peptidase inhibitor Kazal type 14 (putative) OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S9L5-1" }, "locus": { "chromosome": "7", "start_pos": 59445509, "end_pos": 59438071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122998.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122998.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081981.1" } ] } }, { "isoform_ac": "A0AAA9TIQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5/entry#A0AAA9TIQ7-1", "sequence": { "sequence": "MAIPFEVLCSQLFFIPIYLALPSVSGPPRWWLPHGNIKEISGENTST", "length": 47, "header": "tr|A0AAA9TIQ7-1|A0AAA9TIQ7_BOVIN Computationally mapped isoform of Serine peptidase inhibitor Kazal type 14 (putative) OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S9L5-1" }, "locus": { "chromosome": "7", "start_pos": 59445493, "end_pos": 59438071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088836.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088836.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097022.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097022.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L5" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 99, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9N2-1", "uniprot_ac": "A0AAA9S9N2", "uniprot_id": "A0AAA9S9N2_BOVIN", "mass": { "chemical_mass": 72797.0, "monoisotopic_mass": 72797.0 }, "refseq": { "ac": "NP_001421966", "name": "A-kinase anchor protein 10, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421966" }, "gene_names": [ { "name": "AKAP10", "type": "recommended", "evidence": [ { "id": "A0AAA9S9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ] }, { "name": "AKAP10", "type": "synonym", "evidence": [ { "id": "NP_001421966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421966" } ] } ], "protein_names": [ { "name": "A-kinase anchor protein 10, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9S9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#names_and_taxonomy" } ] }, { "name": "A kinase (PRKA) anchor protein 10", "type": "synonym", "evidence": [ { "id": "NP_001421966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421966" } ] }, { "name": "A-kinase anchor protein 10, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001421966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421966" } ] }, { "name": "A-kinase anchor protein 10", "type": "synonym", "evidence": [ { "id": "NP_001421966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421966" } ] }, { "name": "Dual specificity A kinase-anchoring protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9S9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#names_and_taxonomy" } ] }, { "name": "Protein kinase A-anchoring protein 10", "type": "synonym", "evidence": [ { "id": "A0AAA9S9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2#function" }, { "database": "UniProtKB", "id": "ARBA00055118", "url": "https://www.uniprot.org/uniprotkb/ARBA00055118#function" }, { "database": "UniProtKB", "id": "A0AAA9TCJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ0#function" }, { "database": "UniProtKB", "id": "A0AAA9TJR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR4#function" }, { "database": "UniProtKB", "id": "F1MP39", "url": "https://www.uniprot.org/uniprotkb/F1MP39#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKAP10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2", "locus": { "chromosome": "19", "start_pos": 33784099, "end_pos": 33740771, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003439", "url": "https://www.ensembl.org/id/ENSBTAG00000003439" } ] } } ], "crossref": [ { "id": "A0AAA9S9N2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9N2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003439", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003439", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08721", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08721", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08735", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08735", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12804", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12804", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513802", "url": "https://www.ncbi.nlm.nih.gov/gene/513802", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MP39", "url": "https://www.orthodb.org/?gene=F1MP39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13155:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13155:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421966", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP39", "url": "https://www.uniprot.org/uniprotkb/F1MP39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP39-1", "url": "https://www.uniprot.org/uniprotkb/F1MP39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGAGPSPRQSPRALRPDPGPAMSFFRRKVKSKEQEKTPDVKSVKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQEAKSSLSKTLEQVLHDTMVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKPETTAAFVTESLNRRLEDSGSAHLEGIDLNNRTSNSQNHLLSQESDSAHLLHLETARTGTHWGSLETQESSRLMVASRSSPSSPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVSAQSIVFSAMEHEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGSGSLTAPGSMGPPDDSHPGAADSATSQSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQCDQPLEKSTKI", "length": 655, "header": "tr|A0AAA9S9N2-1|A0AAA9S9N2_BOVIN Isoform 1 of A-kinase anchor protein 10, mitochondrial OS=Bos taurus OX=9913 GN=AKAP10 PE=4 SV=2 CANONICAL=A0AAA9S9N2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#A0AAA9S9N2-1", "sequence": { "sequence": "MRGAGPSPRQSPRALRPDPGPAMSFFRRKVKSKEQEKTPDVKSVKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQEAKSSLSKTLEQVLHDTMVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKPETTAAFVTESLNRRLEDSGSAHLEGIDLNNRTSNSQNHLLSQESDSAHLLHLETARTGTHWGSLETQESSRLMVASRSSPSSPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVSAQSIVFSAMEHEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGSGSLTAPGSMGPPDDSHPGAADSATSQSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQCDQPLEKSTKI", "length": 655, "header": "tr|A0AAA9S9N2-1|A0AAA9S9N2_BOVIN Isoform 1 of A-kinase anchor protein 10, mitochondrial OS=Bos taurus OX=9913 GN=AKAP10 PE=4 SV=2 CANONICAL=A0AAA9S9N2-1" }, "locus": { "chromosome": "19", "start_pos": 33782395, "end_pos": 33740799, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129866.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129866.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080637.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080637.2" } ] } }, { "isoform_ac": "A0AAA9TCJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#A0AAA9TCJ0-1", "sequence": { "sequence": "MKSKEQEKTPDVKSVKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQEAKSSLSKTLEQVLHDTMVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKPETTAAFVTESLNRRLEDSGSAHLEGIDLNNRTSNSQNHLLSQESDSAHLLHLETARTGTHWGSLETQESSRLMVASRSSPSSPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVSAQSIVFSAMEHEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGSGSLTAPGSMGPPDDSHPGAADSATSQSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQCDQPLEKSTKI", "length": 626, "header": "tr|A0AAA9TCJ0-1|A0AAA9TCJ0_BOVIN Computationally mapped isoform of A-kinase anchor protein 10, mitochondrial OS=Bos taurus OX=9913 GN=AKAP10 PE=4 SV=1 CANONICAL=A0AAA9S9N2-1" }, "locus": { "chromosome": "19", "start_pos": 33782395, "end_pos": 33748132, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097071.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097071.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095771.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095771.1" } ] } }, { "isoform_ac": "A0AAA9TJR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#A0AAA9TJR4-1", "sequence": { "sequence": "MRGAGPSPRQSPRALRPDPGPAMSFFRRKVKSKEQEKTPDVKSVKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQEAKSSLSKTLEQVLHDTMVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKPETTAAFVTESLNRRLEDSGSAHLEGIDLNNRTSNSQNHLLSQESDSAHLLHLETARTGTHWGSLETQESSRLMVASRSSPSSPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVSAQSIVFSAMEHEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGSGSLTAPGSMGPPDDSHPGAADSATSQSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGDVGLIPSLGRPHMLRSN", "length": 622, "header": "tr|A0AAA9TJR4-1|A0AAA9TJR4_BOVIN Computationally mapped isoform of A-kinase anchor protein 10, mitochondrial OS=Bos taurus OX=9913 GN=AKAP10 PE=4 SV=2 CANONICAL=A0AAA9S9N2-1" }, "locus": { "chromosome": "19", "start_pos": 33778249, "end_pos": 33740799, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099506.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099506.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096494.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096494.2" } ] } }, { "isoform_ac": "F1MP39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2/entry#F1MP39-1", "sequence": { "sequence": "MRGAGPSPRQSPRALRPDPGPAMSFFRRKVKSKEQEKTPDVKSVKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQEAKSSLSKTLEQVLHDTMVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKPETTAAFVTESLNRRLEDSGSAHLEGIDLNNRTSNSQNHLLSQESDSAHLLHLETARTGTHWGSLETQESSRLMVASRSSPSSPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVDPNCFVSAQSIVFSAMEHEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKSSVKKASVKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAQCDQPLEKSTKI", "length": 597, "header": "tr|F1MP39-1|A0AAA9S9N2_BOVIN Computationally mapped isoform of A-kinase anchor protein 10, mitochondrial OS=Bos taurus OX=9913 GN=AKAP10 PE=4 SV=2 CANONICAL=A0AAA9S9N2-1" }, "locus": { "chromosome": "19", "start_pos": 33782395, "end_pos": 33740799, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043861.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043861.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041402.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041402.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase A binding", "id": "GO:0051018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9N2" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 362, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9Q1-1", "uniprot_ac": "A0AAA9S9Q1", "uniprot_id": "A0AAA9S9Q1_BOVIN", "mass": { "chemical_mass": 9145.0, "monoisotopic_mass": 9145.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9S9Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q1", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9Q1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9S9Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "PGKNTGVGCHFLLQCMKVKSESEVAHTCLELPKGSLEKCLIISSHLSKIAAANSTNQRWKNLTLASLQRSSENIDIPGSPRNKK", "length": 84, "header": "tr|A0AAA9S9Q1-1|A0AAA9S9Q1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S9Q1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q1/entry#A0AAA9S9Q1-1", "sequence": { "sequence": "PGKNTGVGCHFLLQCMKVKSESEVAHTCLELPKGSLEKCLIISSHLSKIAAANSTNQRWKNLTLASLQRSSENIDIPGSPRNKK", "length": 84, "header": "tr|A0AAA9S9Q1-1|A0AAA9S9Q1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S9Q1-1" }, "locus": { "chromosome": "2", "start_pos": 74969424, "end_pos": 74968775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113884.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113884.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080652.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080652.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 53, "end_pos": 55 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9R1-1", "uniprot_ac": "A0AAA9S9R1", "uniprot_id": "A0AAA9S9R1_BOVIN", "mass": { "chemical_mass": 117440.0, "monoisotopic_mass": 117440.0 }, "refseq": { "ac": "XP_024844212", "name": "X-linked retinitis pigmentosa GTPase regulator isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844212" }, "gene_names": [ { "name": "RPGR", "type": "recommended", "evidence": [ { "id": "A0AAA9S9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ] }, { "name": "RPGR", "type": "synonym", "evidence": [ { "id": "XP_024844212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844212" } ] } ], "protein_names": [ { "name": "X-linked retinitis pigmentosa GTPase regulator", "type": "recommended", "evidence": [ { "id": "A0AAA9S9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1/entry#names_and_taxonomy" } ] }, { "name": "X-linked retinitis pigmentosa GTPase regulator isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024844212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844212" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPGR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1", "locus": {} } ], "crossref": [ { "id": "A0AAA9S9R1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9R1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045867", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045867", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513263", "url": "https://www.ncbi.nlm.nih.gov/gene/513263", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513263", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513263", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR22872", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22872", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22872:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22872:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844212", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844212", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD33", "url": "https://www.uniprot.org/uniprotkb/F1MD33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD33-1", "url": "https://www.uniprot.org/uniprotkb/F1MD33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPREWLWGSKGLSAPASELRHCLRPSRVDAADFLAEEQAFHSAITMGEPDKMVPDSGAVFTFGKTKFAENMPSKFWFKRDIPISLSCGDEHTAITTGNNKLFMFGSNNWGQLGLGSKATVNKPTCIKALKPEKVKFVACGRNHTLILTGGGQVYATGGNNEGQLGLGDTDERSAFHLISFFTSQHKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLQNITNICVPHQVTIGKPISWISCGYYHSAFVTTEGELYTFGEPESGKLGLPPKLLVNHKVPQLVPGISEKVIQVACGGGHTVVLTEKAVYTFGLGQFGQLGLGTFTFETSEPKVIESVKDKKISHVCCGENHTALITESGLLYTFGDGRHGKLGLGMENFTNQFVPTLCSSFLKYIVHLVACGGCHMLVFATPRLGMAEDIESDEINYSYLPSAIYVPISDPPLENVLQRSLSARVRRREREKSPDSLRMTGILPPVEGTSPQPICFSPHLIPFSMSASNLLVRTICEDENSMPPMEPDYFQHKVTKEKDTDSLSAEDSESLGETADVLNMTHMLHLNSNEKLKLSPIQKQKKQEIIEKPKQHTTYTESDDSNEYENEEISPKVTEGRVYKQLLAQGMYAMPVAISMETFSDEDVGDDSDQQSPQTSTSAEGLQKGTFRHENKHDVYPLNTEEIEKESDEGQSQKDSEANEIVSEMESDLVKMTDLKDIRKTEENRKNTDTFFDDLPNRYMNIEDEEDKDFVKESKGDKQDMIFDSEQASIEEENSYLEGESESQQSIADGFQQSESIEFNSVEKDDDEVETNQNLWYSRTFIKQRHEEARHRLSRIMAKYEFKCDRLSRIPEEQEEDSEGSGVEEQEIEANEEECGEKEKEETELLSDDLTDRAEDHELFENNLAEETDKYTEGKKEDTGDDKSVPKDDHSDTDNSVKKDEKVNREERAIHEYNENPKGNMCDRAKSSSSEILEDNESTPTKDIKKSKIFLFKRMSLMSQKIVQINNEPLPEIKPIGDQIAFKRNKKDANQNHMGQNHQDTSPPNMERRSKSCTIL", "length": 1046, "header": "tr|A0AAA9S9R1-1|A0AAA9S9R1_BOVIN Isoform 1 of X-linked retinitis pigmentosa GTPase regulator OS=Bos taurus OX=9913 GN=RPGR PE=4 SV=1 CANONICAL=A0AAA9S9R1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1/entry#A0AAA9S9R1-1", "sequence": { "sequence": "MPREWLWGSKGLSAPASELRHCLRPSRVDAADFLAEEQAFHSAITMGEPDKMVPDSGAVFTFGKTKFAENMPSKFWFKRDIPISLSCGDEHTAITTGNNKLFMFGSNNWGQLGLGSKATVNKPTCIKALKPEKVKFVACGRNHTLILTGGGQVYATGGNNEGQLGLGDTDERSAFHLISFFTSQHKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLQNITNICVPHQVTIGKPISWISCGYYHSAFVTTEGELYTFGEPESGKLGLPPKLLVNHKVPQLVPGISEKVIQVACGGGHTVVLTEKAVYTFGLGQFGQLGLGTFTFETSEPKVIESVKDKKISHVCCGENHTALITESGLLYTFGDGRHGKLGLGMENFTNQFVPTLCSSFLKYIVHLVACGGCHMLVFATPRLGMAEDIESDEINYSYLPSAIYVPISDPPLENVLQRSLSARVRRREREKSPDSLRMTGILPPVEGTSPQPICFSPHLIPFSMSASNLLVRTICEDENSMPPMEPDYFQHKVTKEKDTDSLSAEDSESLGETADVLNMTHMLHLNSNEKLKLSPIQKQKKQEIIEKPKQHTTYTESDDSNEYENEEISPKVTEGRVYKQLLAQGMYAMPVAISMETFSDEDVGDDSDQQSPQTSTSAEGLQKGTFRHENKHDVYPLNTEEIEKESDEGQSQKDSEANEIVSEMESDLVKMTDLKDIRKTEENRKNTDTFFDDLPNRYMNIEDEEDKDFVKESKGDKQDMIFDSEQASIEEENSYLEGESESQQSIADGFQQSESIEFNSVEKDDDEVETNQNLWYSRTFIKQRHEEARHRLSRIMAKYEFKCDRLSRIPEEQEEDSEGSGVEEQEIEANEEECGEKEKEETELLSDDLTDRAEDHELFENNLAEETDKYTEGKKEDTGDDKSVPKDDHSDTDNSVKKDEKVNREERAIHEYNENPKGNMCDRAKSSSSEILEDNESTPTKDIKKSKIFLFKRMSLMSQKIVQINNEPLPEIKPIGDQIAFKRNKKDANQNHMGQNHQDTSPPNMERRSKSCTIL", "length": 1046, "header": "tr|A0AAA9S9R1-1|A0AAA9S9R1_BOVIN Isoform 1 of X-linked retinitis pigmentosa GTPase regulator OS=Bos taurus OX=9913 GN=RPGR PE=4 SV=1 CANONICAL=A0AAA9S9R1-1" }, "locus": { "chromosome": "X", "start_pos": 105008655, "end_pos": 104948627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092300.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092300.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080662.1" } ] } }, { "isoform_ac": "F1MD33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1/entry#F1MD33-1", "sequence": { "sequence": "MGEPDKMVPDSGAVFTFGKTKFAENMPSKFWFKRDIPISLSCGDEHTAITTGNNKLFMFGSNNWGQLGLGSKATVNKPTCIKALKPEKVKFVACGRNHTLILTGGGQVYATGGNNEGQLGLGDTDERSAFHLISFFTSQHKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLQNITNICVPHQVTIGKPISWISCGYYHSAFVTTEGELYTFGEPESGKLGLPPKLLVNHKVPQLVPGISEKVIQVACGGGHTVVLTEKAVYTFGLGQFGQLGLGTFTFETSEPKVIESVKDKKISHVCCGENHTALITVSAMMELI", "length": 319, "header": "tr|F1MD33-1|A0AAA9S9R1_BOVIN Computationally mapped isoform of X-linked retinitis pigmentosa GTPase regulator OS=Bos taurus OX=9913 GN=RPGR PE=4 SV=5 CANONICAL=A0AAA9S9R1-1" }, "locus": { "chromosome": "X", "start_pos": 104967522, "end_pos": 104948762, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005090.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005090.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005090.8", "url": "https://www.ensembl.org/id/ENSBTAP00000005090.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513263", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513263", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" }, { "name": "photoreceptor distal connecting cilium", "id": "GO:0120206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120206", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" }, { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 549, "end_pos": 551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 966, "end_pos": 968, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R1" }, { "id": "PF25390", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RCC1-like", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 408, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 221, "end_pos": 223 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 426, "end_pos": 428 }, { "start_pos": 549, "end_pos": 551 }, { "start_pos": 966, "end_pos": 968 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9R4-1", "uniprot_ac": "A0AAA9S9R4", "uniprot_id": "A0AAA9S9R4_BOVIN", "mass": { "chemical_mass": 50332.0, "monoisotopic_mass": 50332.0 }, "refseq": {}, "gene_names": [ { "name": "PSMC3", "type": "recommended", "evidence": [ { "id": "A0AAA9S9R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ] } ], "protein_names": [ { "name": "26S proteasome regulatory subunit 6A", "type": "recommended", "evidence": [ { "id": "A0AAA9S9R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome AAA-ATPase subunit RPT5", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4/entry#names_and_taxonomy" } ] }, { "name": "Proteasome 26S subunit ATPase 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4/entry#names_and_taxonomy" } ] }, { "name": "Tat-binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9S9R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4#function" }, { "database": "UniProtKB", "id": "ARBA00055806", "url": "https://www.uniprot.org/uniprotkb/ARBA00055806#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4", "locus": { "chromosome": "15", "start_pos": 77250375, "end_pos": 77258617, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021744", "url": "https://www.ensembl.org/id/ENSBTAG00000021744" } ] } } ], "crossref": [ { "id": "A0AAA9S9R4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9R4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021744", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MWE0", "url": "https://www.orthodb.org/?gene=F1MWE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16450", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16450", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17862", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17862", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1169091", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1234176", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1236978", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174084", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174154", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174184", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-187577", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187577", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-195253", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871837", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-349425", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-349425", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-350562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4608870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641258", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5358346", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5607761", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607761", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5607764", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607764", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5610780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5610785", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610785", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5632684", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5668541", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5676590", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676590", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5687128", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687128", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68867", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69481", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69481", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69601", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75815", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75815", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854050", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854050", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8939236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8939902", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939902", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8941858", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941858", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948751", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9762114", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762114", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9766229", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9766229", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9929356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9929491", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929491", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9932298", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWE0", "url": "https://www.uniprot.org/uniprotkb/F1MWE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWE0-1", "url": "https://www.uniprot.org/uniprotkb/F1MWE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQEMLLLRMVNLLPKLESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA", "length": 448, "header": "tr|A0AAA9S9R4-1|A0AAA9S9R4_BOVIN Isoform 1 of 26S proteasome regulatory subunit 6A OS=Bos taurus OX=9913 GN=PSMC3 PE=1 SV=1 CANONICAL=A0AAA9S9R4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4/entry#A0AAA9S9R4-1", "sequence": { "sequence": "MQEMLLLRMVNLLPKLESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA", "length": 448, "header": "tr|A0AAA9S9R4-1|A0AAA9S9R4_BOVIN Isoform 1 of 26S proteasome regulatory subunit 6A OS=Bos taurus OX=9913 GN=PSMC3 PE=1 SV=1 CANONICAL=A0AAA9S9R4-1" }, "locus": { "chromosome": "15", "start_pos": 77258418, "end_pos": 77250428, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129102.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129102.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082034.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082034.1" } ] } }, { "isoform_ac": "F1MWE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4/entry#F1MWE0-1", "sequence": { "sequence": "VNLLPKLESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKLLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA", "length": 397, "header": "tr|F1MWE0-1|F1MWE0_BOVIN Computationally mapped isoform of Proteasome 26S subunit, ATPase 3 OS=Bos taurus OX=9913 GN=PSMC3 PE=1 SV=4 CANONICAL=A0AAA9S9R4-1" }, "locus": { "chromosome": "15", "start_pos": 77256299, "end_pos": 77250428, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028983.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028983.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028983.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028983.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1169091", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "resource": "Reactome", "description": "Activation of NF-kappaB in B cells" }, { "id": "R-BTA-1234176", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "resource": "Reactome", "description": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" }, { "id": "R-BTA-1236978", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "resource": "Reactome", "description": "Cross-presentation of soluble exogenous antigens (endosomes)" }, { "id": "R-BTA-174084", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174084", "resource": "Reactome", "description": "Autodegradation of Cdh1 by Cdh1:APC/C" }, { "id": "R-BTA-174154", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174154", "resource": "Reactome", "description": "APC/C:Cdc20 mediated degradation of Securin" }, { "id": "R-BTA-174178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "resource": "Reactome", "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "id": "R-BTA-174184", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "resource": "Reactome", "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "id": "R-BTA-187577", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187577", "resource": "Reactome", "description": "SCF(Skp2)-mediated degradation of p27/p21" }, { "id": "R-BTA-195253", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-BTA-202424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "resource": "Reactome", "description": "Downstream TCR signaling" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2871837", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "resource": "Reactome", "description": "FCERI mediated NF-kB activation" }, { "id": "R-BTA-349425", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-349425", "resource": "Reactome", "description": "Autodegradation of the E3 ubiquitin ligase COP1" }, { "id": "R-BTA-350562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350562", "resource": "Reactome", "description": "Regulation of ornithine decarboxylase (ODC)" }, { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-450408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450408", "resource": "Reactome", "description": "AUF1 (hnRNP D0) binds and destabilizes mRNA" }, { "id": "R-BTA-4608870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-BTA-4641257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-BTA-5358346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "resource": "Reactome", "description": "Hedgehog ligand biogenesis" }, { "id": "R-BTA-5607761", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607761", "resource": "Reactome", "description": "Dectin-1 mediated noncanonical NF-kB signaling" }, { "id": "R-BTA-5607764", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607764", "resource": "Reactome", "description": "CLEC7A (Dectin-1) signaling" }, { "id": "R-BTA-5610780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610780", "resource": "Reactome", "description": "Degradation of GLI1 by the proteasome" }, { "id": "R-BTA-5610785", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610785", "resource": "Reactome", "description": "GLI3 is processed to GLI3R by the proteasome" }, { "id": "R-BTA-5632684", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" }, { "id": "R-BTA-5668541", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "resource": "Reactome", "description": "TNFR2 non-canonical NF-kB pathway" }, { "id": "R-BTA-5676590", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676590", "resource": "Reactome", "description": "NIK-->noncanonical NF-kB signaling" }, { "id": "R-BTA-5687128", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687128", "resource": "Reactome", "description": "MAPK6/MAPK4 signaling" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-68867", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "resource": "Reactome", "description": "Assembly of the pre-replicative complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" }, { "id": "R-BTA-69481", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69481", "resource": "Reactome", "description": "G2/M Checkpoints" }, { "id": "R-BTA-69601", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "resource": "Reactome", "description": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A" }, { "id": "R-BTA-75815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75815", "resource": "Reactome", "description": "Ubiquitin-dependent degradation of Cyclin D" }, { "id": "R-BTA-8852276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852276", "resource": "Reactome", "description": "The role of GTSE1 in G2/M progression after G2 checkpoint" }, { "id": "R-BTA-8854050", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854050", "resource": "Reactome", "description": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" }, { "id": "R-BTA-8939236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939236", "resource": "Reactome", "description": "RUNX1 regulates transcription of genes involved in differentiation of HSCs" }, { "id": "R-BTA-8939902", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939902", "resource": "Reactome", "description": "Regulation of RUNX2 expression and activity" }, { "id": "R-BTA-8941858", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941858", "resource": "Reactome", "description": "Regulation of RUNX3 expression and activity" }, { "id": "R-BTA-8948751", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9020702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "resource": "Reactome", "description": "Interleukin-1 signaling" }, { "id": "R-BTA-9755511", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" }, { "id": "R-BTA-9762114", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762114", "resource": "Reactome", "description": "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" }, { "id": "R-BTA-9766229", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9766229", "resource": "Reactome", "description": "Degradation of CDH1" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" }, { "id": "R-BTA-9929356", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "resource": "Reactome", "description": "GSK3B-mediated proteasomal degradation of PD-L1(CD274)" }, { "id": "R-BTA-9929491", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929491", "resource": "Reactome", "description": "SPOP-mediated proteasomal degradation of PD-L1(CD274)" }, { "id": "R-BTA-9931269", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "resource": "Reactome", "description": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)" }, { "id": "R-BTA-9932298", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "resource": "Reactome", "description": "Degradation of CRY and PER proteins" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "proteasome accessory complex", "id": "GO:0022624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022624", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "proteasome regulatory particle, base subcomplex", "id": "GO:0008540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "host-mediated perturbation of viral transcription", "id": "GO:0043921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043921", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" }, { "name": "proteasome-activating activity", "id": "GO:0036402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036402", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9R4" }, { "id": "SM00382", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AAA+ ATPase", "eco_id": "ECO_0000259", "start_pos": 228, "end_pos": 367, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 383, "end_pos": 385 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9T9-1", "uniprot_ac": "A0AAA9S9T9", "uniprot_id": "A0AAA9S9T9_BOVIN", "mass": { "chemical_mass": 17674.0, "monoisotopic_mass": 17674.0 }, "refseq": {}, "gene_names": [ { "name": "SMIM28", "type": "recommended", "evidence": [ { "id": "A0AAA9S9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 28", "type": "synonym", "evidence": [ { "id": "A0AAA9S9T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9", "locus": { "chromosome": "9", "start_pos": 76176649, "end_pos": 76173130, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055950", "url": "https://www.ensembl.org/id/ENSBTAG00000055950" } ] } } ], "crossref": [ { "id": "A0AAA9S9T9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9S9T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ALLGSSWGKFGHAGRGTYEWLTSEPSLPLLETQLQGTQKRSSTREDVEPFLFILLPATVLLFLAFLLLFLYRHCQTPRPQGQVSVLDLPEHPPAGEMTDFLPGLPWSSEQTSPYSPLPPEAALLSKVCSPPSYEEATKDAPGEQALDAGIQCGVGSPGLDKQI", "length": 163, "header": "tr|A0AAA9S9T9-1|A0AAA9S9T9_BOVIN Isoform 1 of Small integral membrane protein 28 OS=Bos taurus OX=9913 GN=SMIM28 PE=4 SV=2 CANONICAL=A0AAA9S9T9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9T9/entry#A0AAA9S9T9-1", "sequence": { "sequence": "ALLGSSWGKFGHAGRGTYEWLTSEPSLPLLETQLQGTQKRSSTREDVEPFLFILLPATVLLFLAFLLLFLYRHCQTPRPQGQVSVLDLPEHPPAGEMTDFLPGLPWSSEQTSPYSPLPPEAALLSKVCSPPSYEEATKDAPGEQALDAGIQCGVGSPGLDKQI", "length": 163, "header": "tr|A0AAA9S9T9-1|A0AAA9S9T9_BOVIN Isoform 1 of Small integral membrane protein 28 OS=Bos taurus OX=9913 GN=SMIM28 PE=4 SV=2 CANONICAL=A0AAA9S9T9-1" }, "locus": { "chromosome": "9", "start_pos": 76176680, "end_pos": 76173136, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108368.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108368.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080191.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080191.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9V2-1", "uniprot_ac": "A0AAA9S9V2", "uniprot_id": "A0AAA9S9V2_BOVIN", "mass": { "chemical_mass": 27688.0, "monoisotopic_mass": 27688.0 }, "refseq": {}, "gene_names": [ { "name": "CYYR1", "type": "recommended", "evidence": [ { "id": "A0AAA9S9V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2" } ] } ], "protein_names": [ { "name": "Cysteine and tyrosine-rich protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S9V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYYR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2", "locus": { "chromosome": "1", "start_pos": 9984682, "end_pos": 9869543, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050914", "url": "https://www.ensembl.org/id/ENSBTAG00000050914" } ] } } ], "crossref": [ { "id": "A0AAA9S9V2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9V2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR022640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR38490", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38490", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR38490:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38490:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10873", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10873", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCEPGWPRTLDLLLSLPPDRPGDRQRDLGHNAALRGRPGSPRKLPARWPGHRATPLSRALPAPSDRPPAPPSSPGAGVAFGSQLSLQTGSACPSVLARHLRPPVWMDARRVPGCPGVLLPKLVLLFVCAEDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRTTHINAISSYPVAPPPYNYDHEMEYCADLPPPYSPTPAQRSPPPPYPGNSRK", "length": 258, "header": "tr|A0AAA9S9V2-1|A0AAA9S9V2_BOVIN Isoform 1 of Cysteine and tyrosine-rich protein 1 OS=Bos taurus OX=9913 GN=CYYR1 PE=3 SV=2 CANONICAL=A0AAA9S9V2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2/entry#A0AAA9S9V2-1", "sequence": { "sequence": "MKCEPGWPRTLDLLLSLPPDRPGDRQRDLGHNAALRGRPGSPRKLPARWPGHRATPLSRALPAPSDRPPAPPSSPGAGVAFGSQLSLQTGSACPSVLARHLRPPVWMDARRVPGCPGVLLPKLVLLFVCAEDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRTTHINAISSYPVAPPPYNYDHEMEYCADLPPPYSPTPAQRSPPPPYPGNSRK", "length": 258, "header": "tr|A0AAA9S9V2-1|A0AAA9S9V2_BOVIN Isoform 1 of Cysteine and tyrosine-rich protein 1 OS=Bos taurus OX=9913 GN=CYYR1 PE=3 SV=2 CANONICAL=A0AAA9S9V2-1" }, "locus": { "chromosome": "1", "start_pos": 9983174, "end_pos": 9869545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108825.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108825.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082856.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082856.2" } ] } }, { "isoform_ac": "A0AAA9T0X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2/entry#A0AAA9T0X4-1", "sequence": { "sequence": "MKCEPGWPRTLDLLLSLPPDRPGDRQRDLGHNAALRGRPGSPRKLPARWPGHRATPLSRALPAPSDRPPAPPSSPGAGVAFGSQLSLQTGSACPSVLARHLRPPVWMDARRVPGCPGVLLPKLVLLFVCAEDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRTTHINAISSYPEHLHEAGIVVNFIYVSIPSVQ", "length": 238, "header": "tr|A0AAA9T0X4-1|A0AAA9T0X4_BOVIN Computationally mapped isoform of Cysteine and tyrosine-rich protein 1 OS=Bos taurus OX=9913 GN=CYYR1 PE=3 SV=1 CANONICAL=A0AAA9S9V2-1" }, "locus": { "chromosome": "1", "start_pos": 9974626, "end_pos": 9869545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125114.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125114.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090206.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090206.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 242, "start_aa": "Thr", "end_pos": 242, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr242", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 242 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9V3-1", "uniprot_ac": "A0AAA9S9V3", "uniprot_id": "A0AAA9S9V3_BOVIN", "mass": { "chemical_mass": 59671.0, "monoisotopic_mass": 59671.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF157", "type": "recommended", "evidence": [ { "id": "A0AAA9S9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" } ] } ], "protein_names": [ { "name": "Zinc finger protein 157", "type": "synonym", "evidence": [ { "id": "A0AAA9S9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF157", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3", "locus": { "chromosome": "X", "start_pos": 85740042, "end_pos": 85706807, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065841", "url": "https://www.ensembl.org/id/ENSBTAG00000065841" } ] } } ], "crossref": [ { "id": "A0AAA9S9V3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9V3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAAGSSIYFDCSPYTHTSPALEGGLVSRVNMPANRKSPQRFPALVPGQPGGSFEGSVSFEDVAVDFTRQEWHTLDLAQRTMHRDVMLENYSNLASVGLCVAKPEMIFKLERGEELWILEEESSDNGYTGSFSLPGANSSVWGNSLRHDNDLQHRKIQTLDQTVKYQKAFYKRMSFVGHKRTHTGERNFECNECGKTYCRKSNLIEHLRIHTGERPYKCGECAKTFSARSYLIAHQKTHTGEKPFECDECGKSFGRKSQLILHQRTHTGERPYECTECGKTFSEKATLMIHQRTHTGEKPYECGECGKTFRVKISLTQHERTHTGEKPYECGACGKNFGAKKSLNQHQRIHTGEKPYKCGECGKFFRLKMTLNNHQRTHTGEKPYQCNECGKSFSVHSSLGIHQRIHTGEKPYECNKCGNAFYVKARLIEHQRMHSGEKPYECSDCGKIFSMKKSLCQHQRTHTGEKLCERNAFSVKVCLINTGEPFECQECGKAFWQKAHLTEHQRTHLGQPLPCTVEKASLR", "length": 524, "header": "tr|A0AAA9S9V3-1|A0AAA9S9V3_BOVIN Isoform 1 of Zinc finger protein 157 OS=Bos taurus OX=9913 GN=ZNF157 PE=3 SV=1 CANONICAL=A0AAA9S9V3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3/entry#A0AAA9S9V3-1", "sequence": { "sequence": "MEAAGSSIYFDCSPYTHTSPALEGGLVSRVNMPANRKSPQRFPALVPGQPGGSFEGSVSFEDVAVDFTRQEWHTLDLAQRTMHRDVMLENYSNLASVGLCVAKPEMIFKLERGEELWILEEESSDNGYTGSFSLPGANSSVWGNSLRHDNDLQHRKIQTLDQTVKYQKAFYKRMSFVGHKRTHTGERNFECNECGKTYCRKSNLIEHLRIHTGERPYKCGECAKTFSARSYLIAHQKTHTGEKPFECDECGKSFGRKSQLILHQRTHTGERPYECTECGKTFSEKATLMIHQRTHTGEKPYECGECGKTFRVKISLTQHERTHTGEKPYECGACGKNFGAKKSLNQHQRIHTGEKPYKCGECGKFFRLKMTLNNHQRTHTGEKPYQCNECGKSFSVHSSLGIHQRIHTGEKPYECNKCGNAFYVKARLIEHQRMHSGEKPYECSDCGKIFSMKKSLCQHQRTHTGEKLCERNAFSVKVCLINTGEPFECQECGKAFWQKAHLTEHQRTHLGQPLPCTVEKASLR", "length": 524, "header": "tr|A0AAA9S9V3-1|A0AAA9S9V3_BOVIN Isoform 1 of Zinc finger protein 157 OS=Bos taurus OX=9913 GN=ZNF157 PE=3 SV=1 CANONICAL=A0AAA9S9V3-1" }, "locus": { "chromosome": "X", "start_pos": 85740042, "end_pos": 85709817, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135796.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135796.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080706.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080706.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 216, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V3" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 129, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9V5-1", "uniprot_ac": "A0AAA9S9V5", "uniprot_id": "A0AAA9S9V5_BOVIN", "mass": { "chemical_mass": 44706.0, "monoisotopic_mass": 44706.0 }, "refseq": { "ac": "XP_010814882", "name": "soluble calcium-activated nucleotidase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814882" }, "gene_names": [ { "name": "CANT1", "type": "recommended", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] }, { "name": "CANT1", "type": "synonym", "evidence": [ { "id": "XP_010814882", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814882" } ] } ], "protein_names": [ { "name": "Soluble calcium-activated nucleotidase 1", "type": "recommended", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.6", "type": "synonym", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5/entry#names_and_taxonomy" } ] }, { "name": "Apyrase homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5/entry#names_and_taxonomy" } ] }, { "name": "soluble calcium-activated nucleotidase 1", "type": "synonym", "evidence": [ { "id": "XP_010814882", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814882" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CANT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5", "locus": { "chromosome": "19", "start_pos": 53406888, "end_pos": 53391298, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009991", "url": "https://www.ensembl.org/id/ENSBTAG00000009991" } ] } } ], "crossref": [ { "id": "A0AAA9S9V5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9V5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009991", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009991", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518086", "url": "https://www.ncbi.nlm.nih.gov/gene/518086", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518086", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518086", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M2J3", "url": "https://www.orthodb.org/?gene=A0A3Q1M2J3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BGL5", "url": "https://www.orthodb.org/?gene=E1BGL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13023:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13023:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010814882", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814882", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36799", "url": "https://www.rhea-db.org/rhea/36799", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M2J3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2J3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGL5", "url": "https://www.uniprot.org/uniprotkb/E1BGL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGL5-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVQLSNPPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILPSFVGAAVLWLLYTHRPPPGRPPLPNTHNWKLVQPPAARYNDTYPLSAPQRTPGGTRYRIAVIADLDTKSRAQEENTWVSYLKKGHLTLSDSGDRVAVEWDQGHEVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSRAVPWVILSDGDGSVGKGFKAEWLAVKDEHLYVGGLGKEWTTATGEVLNENPEWVKVVGCRGSVGHENWVSSYNALRAAAGIRPPGYLIHESACWSDTLQRWFFLPRRASHERYSEKDDERRGTNLLLSATQDFGDITVQHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGQIATYIMAFTLDGRFLLPETKIGSVKYEGIEFI", "length": 401, "header": "tr|A0AAA9S9V5-1|A0AAA9S9V5_BOVIN Isoform 1 of Soluble calcium-activated nucleotidase 1 OS=Bos taurus OX=9913 GN=CANT1 PE=3 SV=1 CANONICAL=A0AAA9S9V5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5/entry#A0A3Q1M2J3-1", "sequence": { "sequence": "MESCVSQGFHGSFDQDSCDYGHPPSLLRFLREELQANVCQKSRQNLDQEVPPPFSLMPVQLSNPPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILPSFVGAAVLWLLYTHRPPPGRPPLPNTHNWKLVQPPAARYNDTYPLSAPQRTPGGTRYRIAVIADLDTKSRAQEENTWVSYLKKGHLTLSDSGDRVAVEWDQGHEVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSRAVPWVILSDGDGSVGKGFKAEWLAVKDEHLYVGGLGKEWTTATGEVLNENPEWVKVVGCRGSVGHENWVSSYNALRAAAGIRPPGYLIHESACWSDTLQRWFFLPRRASHERYSEKDDERRGTNLLLSATQDFGDITVQHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGQIATYIMAFTLDGRFLLPETKIGSVKYEGIEFI", "length": 457, "header": "tr|A0A3Q1M2J3-1|A0A3Q1M2J3_BOVIN Computationally mapped isoform of Soluble calcium-activated nucleotidase 1 OS=Bos taurus OX=9913 GN=CANT1 PE=3 SV=1 CANONICAL=A0AAA9S9V5-1" }, "locus": { "chromosome": "19", "start_pos": 53405884, "end_pos": 53400196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079464.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079464.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067641.1" } ] } }, { "isoform_ac": "A0AAA9S9V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5/entry#A0AAA9S9V5-1", "sequence": { "sequence": "MPVQLSNPPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILPSFVGAAVLWLLYTHRPPPGRPPLPNTHNWKLVQPPAARYNDTYPLSAPQRTPGGTRYRIAVIADLDTKSRAQEENTWVSYLKKGHLTLSDSGDRVAVEWDQGHEVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSRAVPWVILSDGDGSVGKGFKAEWLAVKDEHLYVGGLGKEWTTATGEVLNENPEWVKVVGCRGSVGHENWVSSYNALRAAAGIRPPGYLIHESACWSDTLQRWFFLPRRASHERYSEKDDERRGTNLLLSATQDFGDITVQHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGQIATYIMAFTLDGRFLLPETKIGSVKYEGIEFI", "length": 401, "header": "tr|A0AAA9S9V5-1|A0AAA9S9V5_BOVIN Isoform 1 of Soluble calcium-activated nucleotidase 1 OS=Bos taurus OX=9913 GN=CANT1 PE=3 SV=1 CANONICAL=A0AAA9S9V5-1" }, "locus": { "chromosome": "19", "start_pos": 53405884, "end_pos": 53402163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119193.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119193.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078930.1" } ] } }, { "isoform_ac": "E1BGL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5/entry#E1BGL5-1", "sequence": { "sequence": "MGASLHSSPISYGCLRVPPPFSLMPVQLSNPPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILPSFVGAAVLWLLYTHRPPPGRPPLPNTHNWKLVQPPAARYNDTYPLSAPQRTPGGTRYRIAVIADLDTKSRAQEENTWVSYLKKGHLTLSDSGDRVAVEWDQGHEVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSRAVPWVILSDGDGSVGKGFKAEWLAVKDEHLYVGGLGKEWTTATGEVLNENPEWVKVVGCRGSVGHENWVSSYNALRAAAGIRPPGYLIHESACWSDTLQRWFFLPRRASHERYSEKDDERRGTNLLLSATQDFGDITVQHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGQIATYIMAFTLDGRFLLPETKIGSVKYEGIEFI", "length": 424, "header": "tr|E1BGL5-1|A0AAA9S9V5_BOVIN Computationally mapped isoform of Soluble calcium-activated nucleotidase 1 OS=Bos taurus OX=9913 GN=CANT1 PE=3 SV=2 CANONICAL=A0AAA9S9V5-1" }, "locus": { "chromosome": "19", "start_pos": 53405884, "end_pos": 53392160, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013171.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013171.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013171.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013171.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:518086", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518086", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" }, { "name": "nucleoside diphosphate phosphatase activity", "id": "GO:0017110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017110", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" }, { "name": "GDP phosphatase activity", "id": "GO:0004382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004382", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" }, { "name": "UDP phosphatase activity", "id": "GO:0045134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045134", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" }, { "name": "ADP phosphatase activity", "id": "GO:0043262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteoglycan biosynthetic process", "id": "GO:0030166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36799", "name": "", "equation": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB25-1", "E1BPW0-1", "O18956-1", "G5E5P3-1", "A0AAA9S9V5-1", "A0JND9-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "G3MZH7-1" ], "evidence": [ { "id": "36799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36799" } ] }, { "id": "R-BTA-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, tertiary granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P24627-1", "Q3SZH7-1", "A0AAA9S4U4-1", "A0AAA9S9V5-1", "O46414-1", "P25326-1", "F1MMR6-1", "P80189-1", "P52176-1", "Q17QB3-1", "A7YWG4-1", "F1MJ59-1", "F6RY99-1", "A0A140T8A5-1" ], "evidence": [ { "id": "R-BTA-6798745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798745" } ] }, { "id": "R-BTA-6798749", "name": "Exocytosis of specific granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, specific granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P24627-1", "A0AAA9S9V5-1", "F1N1G1-1", "Q0II59-1", "F1MMR6-1", "P05689-1", "P80189-1", "A7YWG4-1", "E1BPI3-1", "F1MJ59-1", "F6RY99-1", "A6BMK7-1", "Q2KJ64-1" ], "evidence": [ { "id": "R-BTA-6798749", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798749" } ] }, { "id": "R-BTA-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "P80227-1", "A0JNA3-1", "F1MMD5-1", "Q32PF2-1", "Q3SZH7-1", "A0AAA9S4U4-1", "A0AAA9S9V5-1", "P07688-1", "O46414-1", "P25326-1", "P80177-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "F1MMR6-1", "A0ABI0NJH4-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P05689-1", "P46196-1", "P52176-1", "P62935-1", "P68103-1", "Q17QB3-1", "Q3T0Q4-1", "Q27970-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A0AAA9SYX5-1", "A1A4J1-1", "E1BB52-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "A0A3Q1NDQ7-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6800434" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A3Q1LR63", "gene_name": "HK3", "activity": [ { "ec_number": "2.7.1.1", "activity": "D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] } ] }, { "uniprot_ac": "A0A3Q1LTT9", "gene_name": "MAPK14", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0A452DJA8", "gene_name": "PNP", "activity": [ { "ec_number": "2.4.2.1", "activity": "adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine.", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9S4U4", "gene_name": "ALDOC", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] } ] }, { "uniprot_ac": "A0AAA9S9V5", "gene_name": "CANT1", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] } ] }, { "uniprot_ac": "A0AAA9SYX5", "gene_name": "KCMF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9SYX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9SYX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX5" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4J1", "gene_name": "PFKL", "activity": [ { "ec_number": "2.7.1.11", "activity": "beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+).", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] } ] }, { "uniprot_ac": "A6BMK7", "gene_name": "NEU1", "activity": [ { "ec_number": "3.2.1.18", "activity": "Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.", "evidence": [ { "id": "A6BMK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6BMK7" } ] }, { "ec_number": "3.2.1.18", "activity": "", "evidence": [ { "id": "A6BMK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6BMK7" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "E1BPW0", "gene_name": "ENTPD5", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "E1BPW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPW0" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "E1BPW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPW0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHT1", "gene_name": "AGL", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] } ] }, { "uniprot_ac": "F1MJ59", "gene_name": "NIT2", "activity": [ { "ec_number": "3.5.1.3", "activity": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+).", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] }, { "ec_number": "3.5.1.3", "activity": "", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMR6", "gene_name": "CTSD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] } ] }, { "uniprot_ac": "F1MQ78", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.34", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] } ] }, { "uniprot_ac": "F1N1G1", "gene_name": "HPSE", "activity": [ { "ec_number": "3.2.1.166", "activity": "endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.", "evidence": [ { "id": "F1N1G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1G1" } ] }, { "ec_number": "3.2.1.166", "activity": "", "evidence": [ { "id": "F1N1G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1G1" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "G5E5P3", "gene_name": "ENTPD5", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "G5E5P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5P3" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "G5E5P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5P3" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "O46414", "gene_name": "FTH1", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "P05689", "gene_name": "CTSZ", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] } ] }, { "uniprot_ac": "P07688", "gene_name": "CTSB", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P24627", "gene_name": "LTF", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "P24627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P24627" } ] } ] }, { "uniprot_ac": "P25326", "gene_name": "CTSS", "activity": [ { "ec_number": "3.4.22.27", "activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] }, { "ec_number": "3.4.22.27", "activity": "", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P52176", "gene_name": "MMP9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P80177", "gene_name": "MIF", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.2.1", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] } ] }, { "uniprot_ac": "P80189", "gene_name": "LYS", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] } ] }, { "uniprot_ac": "P80227", "gene_name": "APEH", "activity": [ { "ec_number": "3.4.19.1", "activity": "Internal cleavage of oxidized and glycated proteins.", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] }, { "ec_number": "3.4.19.1", "activity": "", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] } ] }, { "uniprot_ac": "Q0II59", "gene_name": "PDXK", "activity": [ { "ec_number": "2.7.1.35", "activity": "pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+).", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] } ] }, { "uniprot_ac": "Q0VCM4", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] } ] }, { "uniprot_ac": "Q17QB3", "gene_name": "ASAH1", "activity": [ { "ec_number": "3.5.1.23", "activity": "an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid.", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.23", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] } ] }, { "uniprot_ac": "Q27970", "gene_name": "CAPN1", "activity": [ { "ec_number": "3.4.22.52", "activity": "Broad endopeptidase specificity.", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] }, { "ec_number": "3.4.22.52", "activity": "", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] } ] }, { "uniprot_ac": "Q2KJ64", "gene_name": "ARG1", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] } ] }, { "uniprot_ac": "Q32PF2", "gene_name": "ACLY", "activity": [ { "ec_number": "2.3.3.8", "activity": "oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA.", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] } ] }, { "uniprot_ac": "Q3SWY3", "gene_name": "IMPDH2", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZ62", "gene_name": "PGAM1", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] } ] }, { "uniprot_ac": "Q3SZH7", "gene_name": "LTA4H", "activity": [ { "ec_number": "3.3.2.6", "activity": "leukotriene A4 + H2O = leukotriene B4.", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] }, { "ec_number": "3.4.11.4", "activity": "Release of the N-terminal residue from a tripeptide.", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] }, { "ec_number": "3.3.2.6", "activity": "", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] } ] }, { "uniprot_ac": "Q3T0A3", "gene_name": "CFD", "activity": [ { "ec_number": "3.4.21.46", "activity": "Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.", "evidence": [ { "id": "Q3T0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A3" } ] }, { "ec_number": "3.4.21.46", "activity": "", "evidence": [ { "id": "Q3T0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A3" } ] } ] }, { "uniprot_ac": "Q3T0Q4", "gene_name": "NME2", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] } ] }, { "uniprot_ac": "Q3T0V9", "gene_name": "DERA", "activity": [ { "ec_number": "4.1.2.4", "activity": "2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.", "evidence": [ { "id": "Q3T0V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V9" } ] }, { "ec_number": "4.1.2.4", "activity": "", "evidence": [ { "id": "Q3T0V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V9" } ] } ] }, { "uniprot_ac": "Q3ZBD7", "gene_name": "GPI", "activity": [ { "ec_number": "5.3.1.9", "activity": "alpha-D-fructose 6-phosphate = beta-D-fructose 6-phosphate.", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] }, { "ec_number": "5.3.1.9", "activity": "", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] }, { "ec_number": "5.1.3.-", "activity": "", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q58DK5", "gene_name": "ALAD", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+).", "evidence": [ { "id": "Q58DK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK5" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "Q58DK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK5" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5#function" }, { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 168, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 168, "end_pos": 168, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5#function" }, { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 169, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 169, "end_pos": 169, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5#function" }, { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 191, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 191, "end_pos": 191, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5#function" }, { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 192, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 192, "end_pos": 192, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5#function" }, { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 215, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 215, "end_pos": 215, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3#function" }, { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 224, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 224, "end_pos": 224, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3#function" }, { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 225, "amino_acid": "Tyr", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 225, "end_pos": 225, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5#function" }, { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 238, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 238, "end_pos": 238, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3#function" }, { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 271, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 271, "end_pos": 271, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5#function" }, { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 284, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 284, "end_pos": 284, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5#function" }, { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 307, "amino_acid": "Tyr", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 307, "end_pos": 307, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3#function" }, { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 340, "amino_acid": "Pro", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 340, "end_pos": 340, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5#function" }, { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 345, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 345, "end_pos": 345, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5#function" }, { "id": "E1BGL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGL5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 368, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 368, "end_pos": 368, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5#function" }, { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 396, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 396, "end_pos": 396, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3#function" }, { "id": "A0A3Q1M2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2J3" }, { "id": "PIRSR609283-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609283-1" } ], "binding_site_uniprot": 401, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 401, "end_pos": 401, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.6", "ec_name": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "3.6.1.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6" }, { "id": "3.6.1.6", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.6" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9V9-1", "uniprot_ac": "A0AAA9S9V9", "uniprot_id": "A0AAA9S9V9_BOVIN", "mass": { "chemical_mass": 31828.0, "monoisotopic_mass": 31828.0 }, "refseq": {}, "gene_names": [ { "name": "FBXO36", "type": "recommended", "evidence": [ { "id": "A0AAA9S9V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9" } ] } ], "protein_names": [ { "name": "F-box protein 36", "type": "synonym", "evidence": [ { "id": "A0AAA9S9V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9V9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9", "locus": { "chromosome": "2", "start_pos": 118069148, "end_pos": 117961885, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010338", "url": "https://www.ensembl.org/id/ENSBTAG00000010338" } ] } } ], "crossref": [ { "id": "A0AAA9S9V9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9V9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22106", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22106", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14381:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14381:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9V9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9V9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3J4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASWLPETLFEIVGQGPAPSKDYYQLLVTRFQVIFRWWKISLRSEYRSTKPGETKETHEDFLEKSHLQVQIALIFGSRILDYVFNLCEGKFDFLERLSDSLLLNIISYLDLEDIARLSQTSRRFAKKESRMHGSKAGPHQGQAKGGESGLLGLLKLWVGSGSWYDQLGPHTSCACRTNCGSRSSGAPVTTSPPTCEPWPRTWVGDRCTSPTSCSSSGTSARGSSGREASEAVSSRCTSSRRRGVGGTAVFSFCVRPLPLPSLKGTAADSRCHRVLAHARSTLPASARSFA", "length": 290, "header": "tr|A0AAA9S9V9-1|A0AAA9S9V9_BOVIN Isoform 1 of F-box protein 36 OS=Bos taurus OX=9913 GN=FBXO36 PE=4 SV=1 CANONICAL=A0AAA9S9V9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9V9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9/entry#A0AAA9S9V9-1", "sequence": { "sequence": "MASWLPETLFEIVGQGPAPSKDYYQLLVTRFQVIFRWWKISLRSEYRSTKPGETKETHEDFLEKSHLQVQIALIFGSRILDYVFNLCEGKFDFLERLSDSLLLNIISYLDLEDIARLSQTSRRFAKKESRMHGSKAGPHQGQAKGGESGLLGLLKLWVGSGSWYDQLGPHTSCACRTNCGSRSSGAPVTTSPPTCEPWPRTWVGDRCTSPTSCSSSGTSARGSSGREASEAVSSRCTSSRRRGVGGTAVFSFCVRPLPLPSLKGTAADSRCHRVLAHARSTLPASARSFA", "length": 290, "header": "tr|A0AAA9S9V9-1|A0AAA9S9V9_BOVIN Isoform 1 of F-box protein 36 OS=Bos taurus OX=9913 GN=FBXO36 PE=4 SV=1 CANONICAL=A0AAA9S9V9-1" }, "locus": { "chromosome": "2", "start_pos": 118062299, "end_pos": 117962262, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133457.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133457.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082091.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082091.1" } ] } }, { "isoform_ac": "A0AAA9SP70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9/entry#A0AAA9SP70-1", "sequence": { "sequence": "MASWLPETLFEIVGQGPAPSKDYYQLLVTRFQVIFRWWKISLRSEYRSTKPGETKETHEDFLEKSHLQVQIALIFGSRILDYVFNLCEGKFDFLERLSDSLLLNIISYLDLEDIARLSQTSRRFAKKESRMHGSKAGPHQGQAKGGESGLLGLLKLWVGSGSWYDQLGPHTSYNRRMDVGEPSPGVTPNHQCEKKCCFLLHSFGCY", "length": 206, "header": "tr|A0AAA9SP70-1|A0AAA9SP70_BOVIN Computationally mapped isoform of F-box protein 36 OS=Bos taurus OX=9913 GN=FBXO36 PE=4 SV=1 CANONICAL=A0AAA9S9V9-1" }, "locus": { "chromosome": "2", "start_pos": 118059232, "end_pos": 117962262, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117288.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117288.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085776.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085776.1" } ] } }, { "isoform_ac": "A0AAA9T3J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9/entry#A0AAA9T3J4-1", "sequence": { "sequence": "ERSVPFTSAGSCNDVSQGDGGRSSQEVIFRWWKISLRSEYRSTKPGETKETHEDFLEKSHLQVQIALIFGSRILDYVFNLCEGKFDFLERLSDSLLLNIISYLDLEDIARLSQTSRRFAKLCMSDELWEQIVRSSCDHITPDMRALAQDMGWRQMYFTNKLQLQRHLRKRKQRQGSQRSSQL", "length": 182, "header": "tr|A0AAA9T3J4-1|A0AAA9T3J4_BOVIN Computationally mapped isoform of F-box protein 36 OS=Bos taurus OX=9913 GN=FBXO36 PE=4 SV=1 CANONICAL=A0AAA9S9V9-1" }, "locus": { "chromosome": "2", "start_pos": 118062130, "end_pos": 117979782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092017.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092017.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091210.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091210.1" } ] } }, { "isoform_ac": "A0AAA9TYV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9/entry#A0AAA9TYV6-1", "sequence": { "sequence": "MLWPAVKLELKNAKSLQSCPTLCDPIDGSPSGSPVPGILQVIFRWWKISLRSEYRSTKPGETKETHEDFLEKSHLQVQIALIFGSRILDYVFNLCEGKFDFLERLSDSLLLNIISYLDLEDIARLSQTSRRFAKLCMSDELWEQIVRSSCDHITPDMRALAQDMGWRQMYFTNKLQLQRHLRKRKQRQGSQRSSQL", "length": 196, "header": "tr|A0AAA9TYV6-1|A0AAA9TYV6_BOVIN Computationally mapped isoform of F-box protein 36 OS=Bos taurus OX=9913 GN=FBXO36 PE=4 SV=1 CANONICAL=A0AAA9S9V9-1" }, "locus": { "chromosome": "2", "start_pos": 118062130, "end_pos": 117997517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103522.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V9" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 91, "end_pos": 124, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9Y1-1", "uniprot_ac": "A0AAA9S9Y1", "uniprot_id": "A0AAA9S9Y1_BOVIN", "mass": { "chemical_mass": 14689.0, "monoisotopic_mass": 14689.0 }, "refseq": {}, "gene_names": [ { "name": "POLR1H", "type": "recommended", "evidence": [ { "id": "A0AAA9S9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ] } ], "protein_names": [ { "name": "DNA-directed RNA polymerase I subunit RPA12", "type": "recommended", "evidence": [ { "id": "A0AAA9S9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase I subunit H", "type": "synonym", "evidence": [ { "id": "A0AAA9S9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1#function" }, { "database": "UniProtKB", "id": "ARBA00044497", "url": "https://www.uniprot.org/uniprotkb/ARBA00044497#function" }, { "database": "UniProtKB", "id": "A0AAF6ZFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" } ] }, { "annotation": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "database": "UniProtKB", "id": "PIRNR005586", "url": "https://www.uniprot.org/uniprotkb/PIRNR005586#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLR1H", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1", "locus": { "chromosome": "23", "start_pos": 28917109, "end_pos": 28920646, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031792", "url": "https://www.ensembl.org/id/ENSBTAG00000031792" } ] } } ], "crossref": [ { "id": "A0AAA9S9Y1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9Y1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10507", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10507", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11239:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11239:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPLPPGTKFAINYDVTANRQAERRGSLARPALATSLPRRAGVLACGVGFPFSPVPDFEGKVVKTSVVFNKLGTAMPLSMEEGPEFQGPVVDRRCSRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKFQEKEDS", "length": 134, "header": "tr|A0AAA9S9Y1-1|A0AAA9S9Y1_BOVIN Isoform 1 of DNA-directed RNA polymerase I subunit RPA12 OS=Bos taurus OX=9913 GN=POLR1H PE=3 SV=1 CANONICAL=A0AAA9S9Y1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1/entry#A0AAA9S9Y1-1", "sequence": { "sequence": "MVPLPPGTKFAINYDVTANRQAERRGSLARPALATSLPRRAGVLACGVGFPFSPVPDFEGKVVKTSVVFNKLGTAMPLSMEEGPEFQGPVVDRRCSRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKFQEKEDS", "length": 134, "header": "tr|A0AAA9S9Y1-1|A0AAA9S9Y1_BOVIN Isoform 1 of DNA-directed RNA polymerase I subunit RPA12 OS=Bos taurus OX=9913 GN=POLR1H PE=3 SV=1 CANONICAL=A0AAA9S9Y1-1" }, "locus": { "chromosome": "23", "start_pos": 28920623, "end_pos": 28917306, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128649.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128649.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080733.1" } ] } }, { "isoform_ac": "A0AAF6ZFE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1/entry#A0AAF6ZFE9-1", "sequence": { "sequence": "SVMDLAGICSSFQSDLDFCPDCGSVLPLPGVQDAVACTRCGFSINVRDFEGKVVKTSVVFNKLGTAMPLSMEEGPEFQGPVVDRRCSRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKFQEKEDS", "length": 125, "header": "tr|A0AAF6ZFE9-1|A0AAF6ZFE9_BOVIN Computationally mapped isoform of DNA-directed RNA polymerase subunit OS=Bos taurus OX=9913 GN=POLR1H PE=3 SV=1 CANONICAL=A0AAA9S9Y1-1" }, "locus": { "chromosome": "23", "start_pos": 28920244, "end_pos": 28917306, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045075.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045075.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042491.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042491.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "RNA polymerase I complex", "id": "GO:0005736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005736", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase complex", "id": "GO:0000428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000428", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "DNA-directed RNA polymerase activity", "id": "GO:0003899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transcription elongation by RNA polymerase I", "id": "GO:0006362", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006362", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y1" }, { "id": "PS51133", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51133" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TFIIS-type", "eco_id": "ECO_0000259", "start_pos": 91, "end_pos": 131, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 114, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 114, "end_pos": 114, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 117, "amino_acid": "Gln", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 117, "end_pos": 117, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 19, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 19, "end_pos": 19, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 22, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 22, "end_pos": 22, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 37, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 37, "end_pos": 37, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 40, "amino_acid": "Arg", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 40, "end_pos": 40, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 86, "amino_acid": "Phe", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 86, "end_pos": 86, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9#function" }, { "id": "A0AAF6ZFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFE9" }, { "id": "PIRSR005586-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR005586-1" } ], "binding_site_uniprot": 89, "amino_acid": "Pro", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 89, "end_pos": 89, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9Z3-1", "uniprot_ac": "A0AAA9S9Z3", "uniprot_id": "A0AAA9S9Z3_BOVIN", "mass": { "chemical_mass": 61992.0, "monoisotopic_mass": 61992.0 }, "refseq": {}, "gene_names": [ { "name": "MGAT3", "type": "recommended", "evidence": [ { "id": "A0AAA9S9Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ] } ], "protein_names": [ { "name": "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9S9Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MGAT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3", "locus": { "chromosome": "5", "start_pos": 110912544, "end_pos": 110871469, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012503", "url": "https://www.ensembl.org/id/ENSBTAG00000012503" } ] } } ], "crossref": [ { "id": "A0AAA9S9Z3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012503", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012503", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520087", "url": "https://www.ncbi.nlm.nih.gov/gene/520087", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520087", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520087", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BJA5", "url": "https://www.orthodb.org/?gene=E1BJA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12224:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12224:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04724", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04724", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-975574", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975574", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJA5", "url": "https://www.uniprot.org/uniprotkb/E1BJA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFSRMKMKRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGSPDLLRTPLYSHSPLLQPLSPSKATEELHRMDFVLPEDTTEYFVRTKAGGVCFKPGTKMLEKPPSGRPEEKVEAGDGASSSARGPGRQLLSTRERAGSRGGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPLGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQTVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLDNPYREPKSTAAGGWRNKGSEGRPPARGKLDVVEG", "length": 541, "header": "tr|A0AAA9S9Z3-1|A0AAA9S9Z3_BOVIN Isoform 1 of Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MGAT3 PE=4 SV=1 CANONICAL=A0AAA9S9Z3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3/entry#A0AAA9S9Z3-1", "sequence": { "sequence": "MGFSRMKMKRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGSPDLLRTPLYSHSPLLQPLSPSKATEELHRMDFVLPEDTTEYFVRTKAGGVCFKPGTKMLEKPPSGRPEEKVEAGDGASSSARGPGRQLLSTRERAGSRGGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPLGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQTVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLDNPYREPKSTAAGGWRNKGSEGRPPARGKLDVVEG", "length": 541, "header": "tr|A0AAA9S9Z3-1|A0AAA9S9Z3_BOVIN Isoform 1 of Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MGAT3 PE=4 SV=1 CANONICAL=A0AAA9S9Z3-1" }, "locus": { "chromosome": "5", "start_pos": 110908310, "end_pos": 110904240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119656.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119656.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082128.1" } ] } }, { "isoform_ac": "A0AAA9TB24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3/entry#A0AAA9TB24-1", "sequence": { "sequence": "MKMKRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGSPDLLRTPLYSHSPLLQPLSPSKATEELHRMDFVLPEDTTEYFVRTKAGGVCFKPGTKMLEKPPSGRPEEKVEAGDGASSSARGPGRQLLSTRERAGSRGGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPLGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQTVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLDNPYREPKSTAAGGWRNKGSEGRPPARGKLDVVEG", "length": 536, "header": "tr|A0AAA9TB24-1|A0AAA9TB24_BOVIN Computationally mapped isoform of Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MGAT3 PE=4 SV=1 CANONICAL=A0AAA9S9Z3-1" }, "locus": { "chromosome": "5", "start_pos": 110908310, "end_pos": 110906703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118154.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118154.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081337.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081337.1" } ] } }, { "isoform_ac": "A0AAA9TGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3/entry#A0AAA9TGS8-1", "sequence": { "sequence": "MMKMKRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGSPDLLRTPLYSHSPLLQPLSPSKATEELHRMDFVLPEDTTEYFVRTKAGGVCFKPGTKMLEKPPSGRPEEKVEAGDGASSSARGPGRQLLSTRERAGSRGGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPLGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQTVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLDNPYREPKSTAAGGWRNKGSEGRPPARGKLDVVEG", "length": 537, "header": "tr|A0AAA9TGS8-1|A0AAA9TGS8_BOVIN Computationally mapped isoform of Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MGAT3 PE=4 SV=1 CANONICAL=A0AAA9S9Z3-1" }, "locus": { "chromosome": "5", "start_pos": 110908310, "end_pos": 110871640, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097400.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097400.1" } ] } }, { "isoform_ac": "E1BJA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3/entry#E1BJA5-1", "sequence": { "sequence": "MKMKRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGSPDLLRTPLYSHSPLLQPLSPSKATEELHRMDFVLPEDTTEYFVRTKAGGVCFKPGTKMLEKPPSGRPEEKVEAGDGASSSARGPGRQLLSTRERAGSRGGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPLGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQTVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLDNPYREPKSTAAGGLQSPGRRPQVQN", "length": 527, "header": "tr|E1BJA5-1|A0AAA9S9Z3_BOVIN Computationally mapped isoform of Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MGAT3 PE=4 SV=4 CANONICAL=A0AAA9S9Z3-1" }, "locus": { "chromosome": "5", "start_pos": 110912389, "end_pos": 110906703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016591.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016591.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016591.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016591.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520087", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520087", "resource": "KEGG Pathway" }, { "id": "R-BTA-975574", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975574", "resource": "Reactome", "description": "Reactions specific to the hybrid N-glycan synthesis pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "id": "GO:0003830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003830", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "pmid": "" }, { "name": "glycosyltransferase activity", "id": "GO:0016757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "pmid": "" }, { "name": "N-acetylglucosamine metabolic process", "id": "GO:0006044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006044", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00085FR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00104PH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00123NG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00247PL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00301IL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00330GX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00348IY", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G00349CA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00357HK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00361YF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00369RM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00383YF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00463XD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00468KU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00504PZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00565QJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G00584KG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00584LL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00666EC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00669WU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00695JO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00706YM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00709CF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00745XU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00748RT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00817BI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00826SV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00842OY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00864TV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00884ZO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00951UF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00966RI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01001RL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01079TS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G01092NQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01163CA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01186OB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01233YR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01239JD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01275YS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01367ZS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G01385UC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01454UB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01472KD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01521YU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01571OF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01657DW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G01674EC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01685IB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01701XV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01733NS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01772UL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01868JD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01912KI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01923XE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01954BU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01962HY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01978EJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02025MF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02057LB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02117MY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02290KA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02407HJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G02441OB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02494HC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G02630BJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02681BC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02684XX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02841EM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02900JI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03021PP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03061OY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03081NO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03175VZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03219BR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03272YQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03404VQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03473UD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03583SA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03595ET", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G03622FE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03679BF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03682TM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03695SF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G03744SM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G03750RD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03764XL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03802LT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G03818JD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G03889MY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03941LE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03962UN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G03974HM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03984TW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04019SU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04078TP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04105TN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04118JZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04139WS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04163JP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04209KR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04261UG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G04292RV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04315TN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04355NX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04360YI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04379SJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04420BS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04453SY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04477MN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04528DU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04544OS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04595ZA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04607LO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04717US", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04719BG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04745QB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04751SB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04767HS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04800YX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04820ZR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04861MP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04964UA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05027SR", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G05043WP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05081PF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05107UT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05136IK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05178EM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05307LM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05356QG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05365PX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05395ZW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05553PQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05667QP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05794RZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G05817PZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05837QA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G05840XL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05850WN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05871NN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05919HM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G05951CP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G06017WG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06043RU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06078SG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06098RX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G06138VL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06142UM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06276SU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G06314LQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06317MJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G06404ZJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06407UW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06428EP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06446LG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06535JA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06589PI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06619XB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06705NF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G06772YH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G06816PT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06857RO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G06945SR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07140RV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07209EH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07218NO", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G07228BR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07262RR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07374NR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07414JA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07415VH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07417LG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07429FY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07462LM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G07558KL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07589QZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07666IB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07757CG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07800ED", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07865ET", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08070PH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08076GP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G08083RQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08111FJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08191RW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08240HN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08305OV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G08344IT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08371QU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08550XN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G08597BP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08627LE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G08627VP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G08703ZO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G08774YL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08826KQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08896RO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08926XV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G08977WW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G09032EY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09089WF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G09125WG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09130LO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09142NP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09255AF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09320DG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09326PI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G09344ZL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G09352OR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09365FC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09446VC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09453OL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09538YE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09571HJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09605DV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09650BK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09652ZI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G09664GG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09666WO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09713JE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09820OL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09843LS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10006KY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10026RE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10154BC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10194GS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10240SH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10270EI", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G10303AO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10317HK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10374DW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10409DZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10429ZB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10438OU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10483PN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10507XI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10562QT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10564DZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10580RD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10618UB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10641UB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G10650OV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10663SB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10733HY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10819DS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10820KD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10828WL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10843VM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10898KH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10920IN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11010YY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11012KS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11179AM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11182ZX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11192EU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11192KF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G11200NG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11202LT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11256DQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11265WN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G11287YT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11318MQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11332WD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11441NW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11477VF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11535IB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G11540FP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11551UU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11641YE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G11683GE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11801TI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11948QD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11970DE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11983UH", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G12061NJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12085IM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12086GM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G12146BU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12150CK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12164FF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12187FG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12266SO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12318EJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12586PN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12704ID", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12740VA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12762FV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12772BG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12845LL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12902VJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12925HU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12976MZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13030IT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13064UV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13077RN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13095WF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13123UI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13173KH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13185SY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13196IZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13251BI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13366PY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13370OX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13484HA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13521NM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13634RR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13672YG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13687TQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13696DW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13745OH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13753JW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13810MT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13849JB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13849RQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13865MD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G13872SB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13876TM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13968LT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14010WM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14035PE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14047MI", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G14054GG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14057WB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14127XU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14190WK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14196TN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14281OH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14301PU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14443NT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14478ZZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14739HI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14741HG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14772AX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14809NR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14840SZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14846OX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14854WL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14920YO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14959WS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14963SG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14998JE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14998UC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15025FT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15065YV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15103WJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15111ZN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15164ZG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15265TQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G15310YY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15410OI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15525QB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15571KX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15677VA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15687EU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15688CE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15705XB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15717HW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15720UK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15807GH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G15860LG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15887VX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15898FJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G15987FM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15988BO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16011FK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16057DE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16289YK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16293AI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16341ZC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16379FL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16397GM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16402DK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16425UP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16475ZM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16486ID", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16542VW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16546ZZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16606QC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16633EB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16743OM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16778ZK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16797FX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16873EF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16943PO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16946UG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16976BN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17032PX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17044PM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17101AZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17172ZR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17259TC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17264LS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17266HP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17361WJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17441OD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17469LP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17473NR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17483AZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17483QF", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G17545ER", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17594CH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17621NP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17644VM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17655LC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17769YX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17799CZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17801HD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17807LO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17843GH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17848HM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17856XT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17867XD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17882EL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17927PV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17960CK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17987CU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18026EK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18043EY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18080BJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18129IO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18144ZF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18147RC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18157KC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18199UJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18211PK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18216ZD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18365AZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18391PU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18393MZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18420EN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G18422YU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18430SJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18512IC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18544KO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18562HB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18578CO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18630TP", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G18731YY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18733MI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18756YE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18803CK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18806VU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G18814PP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18862IC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18875WG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18883GY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18890TE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18942HR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18958EQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19099PA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19206WR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19221SF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19267AT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19271GD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19273EM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19293KL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G19430NR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19511ID", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19526IZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19561MR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19648XQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19668AC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19677BZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19689QF", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G19790PJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G19894RH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19906BM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19940DW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19941RO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19962YD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20054JA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20079RG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G20088JQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G20096RP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G20147UM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20167OW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G20168MP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20180NF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G20197BG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20297OI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G20494RJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G20508DJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20564XL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20737NH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G20744OH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20895FL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20966TZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G20983SP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21021HG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21098ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21159AT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21167SG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21168XK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21179ZG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21195ZJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21218WO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21236IX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21251LN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21280KW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21361AZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21380FF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21391VZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21393DK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21432UE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21451CA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21457YV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21498SM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21508HF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21550DG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21679ID", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21729HC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21733DU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21751SS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21767ND", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21788RU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21838QU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21858EN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21901SY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21969LH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G22011DS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22022NY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G22078MT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22098NU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22120QI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G22137OG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G22152RD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G22170TU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G22204JI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G22260JR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22265BO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G22267WV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22330AF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22367YH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22387ST", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G22533WA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G22558JP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G22587DK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22607MW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22638DS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22650VK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22678XU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G22787UZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22795QB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22868PF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22893QE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G22906YL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23008ZY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23025EY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G23060KN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23072OZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23142ED", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23210FC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23228DD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23307DT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23322BE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23343YD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23362IZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23378YH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23394RR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23402XL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23419AQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23503KU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23572BH", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G23577TY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G23581SB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G23643IM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23661JI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23689AE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23713VB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23773ZI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23833ZQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G23901NY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G23914JN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23980PE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G24000JV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G24078MY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G24131KD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24292VT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24364HL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24371XA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24382RE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G24416SU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24422GQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24531RS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24541XL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G24694RX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G24744SN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24758NZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G24849NM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24888ZY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G24914SY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G24930XV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24936MG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25019NQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25067BP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25069TE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25140TA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G25164FO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G25180HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25200CR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25251YZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25264CN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25317UI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25403ZF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25426UG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25520XG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25614IV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25657HD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25764FB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25787HL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25822UT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25890BU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25926OL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25961NT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25967ER", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26014MK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26027SF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26069FK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G26070CR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26072HQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26109NE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26123CC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26150FI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26215AL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26229WS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26274XD", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G26275JI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26341ZJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26371XR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26399DO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G26403JU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26413UF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26566WH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G26644DW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26646BT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26789EP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26798CI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26891DY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26891RG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26896YH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26911EP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26919JW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G26945GA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G26999VA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G27017AZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G27123NH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27196XM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27225SN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G27241WX", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G27263RW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G27270KD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G27293OK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27323FR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27445YH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G27459KS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27461ST", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27485TQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27501HT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27571QK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G27576NC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G27591RM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G27739MC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27802PW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G27898DU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G27901SD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G28106QA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28136CO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28183PJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G28213WT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G28222JZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28263CO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G28371QL", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G28373XJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28433TM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28449NP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28570RY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28659UB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G28678TH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28789PR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G28845EU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28846QB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G28870UM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29025AG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29080UT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29192AY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29244NH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29378QK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29468MY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29481QM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29526MI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29539MT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29610GQ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G29633ZY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G29649MR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29713JZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29721UX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29752WB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29829UF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29884LW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29895JE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G29904GH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G29954VQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29957LS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G29965TU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30005SW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30013YE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30085SO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30149NP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G30159WR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30195UO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30202PY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G30242JS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30243PD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30265AO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G30282AD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30309QX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30333DL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30346SO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30400UW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G30447IO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30482TE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30519RC", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G30553TG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30579TY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30590GW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30623ZE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30644AZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30660KE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30804NF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G30821DO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30837TR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30864MF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30878SA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30915AU", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G30968MT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30973LD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G30980DP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31020MO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G31040SL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G31097EL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G31105VN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G31146VU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31220IW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G31231LV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G31329VE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31333ML", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31337VE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31411IU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G31426KU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31456BO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G31495XA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31561GU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31577VK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G31601BZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G31670BC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31679YU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31700GV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31701OO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31739SV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G31824MM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G31859DB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32065KX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32107HF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32116UD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G32144XK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32146GG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32169DS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32205YW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32332OM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32340YV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G32378BV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32386AG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32395UL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32429DG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32452EX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32489DL", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G32490LW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G32514NN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32525MO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32525PS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32532CU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32615ZF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G32646BW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32705EO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32711TF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32727OR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32768NF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32799YM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G32808NL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G32820BV", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G32871YT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G32898UF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G32977ZV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G32995JP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33013AY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33070ZL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G33150PJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33200MA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G33226VI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G33230CR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33234RY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33251FY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33262YZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33279YE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33295DT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33339PQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33342UZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G33387VL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33487SK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33502UB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33578EQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33660HO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G33709IR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33718MC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33733QM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G33748AU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G33753EI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33780DA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G33785ND", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G33806LP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33851AM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33854YU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G33892NB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G33947BV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33981FE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G33991ME", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34029JA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34129PR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34211EA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34225AE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34259YJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34277BH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34317IP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34424TR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34462PB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34527RW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G34549PC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34561BL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34621DB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34702PI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G34753FI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34768FN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34851VW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34883GV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34962ER", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34985DS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G34988BO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35036QD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35247EJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35383IJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G35502ZW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35523WT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35610QW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35619UY", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G35626TC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35645TY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35655SC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35662PP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35679TE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35687VS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35698OP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35724PH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35734MQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35754WD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35872TD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35911CD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35912PE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35952BG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G35986YT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36115SK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36138QU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36155VO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36167NI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36182DP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36201JW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36255NB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36259JQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36286FT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36293DS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36348OS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36388QQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36399IB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36498AN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36501YX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G36525YB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36537XZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36651MN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36656LV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36727NJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36747XY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36756NY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36816DT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36936QT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36961BD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G37002FU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G37022IM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37046CZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37140SO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G37291PT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G37318XK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G37348LW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37465NJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37491LV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37676KD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37689LY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37780QM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37783EW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37841WI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37885IZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G38001FQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38002QN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38002XF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38047QV", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G38109CU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38112KT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G38208CY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38322BG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G38549YL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38643HC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G38659HF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G38748VM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38753OV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38773BX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G38800CP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G38835AV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38843SX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38883QO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G38908KI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G38930WU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G38951VC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G38955TH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G38956YE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39029JR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39032NB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39062YR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39075QA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39116LG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39125OY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39167RG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39181YB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39186HR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39340CD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39374GZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39401OQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39408YK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39444QC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39465KG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39472EX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39492DS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39515DI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39540XG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39565DV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39566TW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39623FZ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G39687OP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G39716GO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39757QQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39758CF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39765RY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39797QC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39944FZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39945EK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40012WS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40013GE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40044ME", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G40069AV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40074SP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40136EV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40181EN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G40182HE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40189YT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40212MM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40221OX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40239DI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40268BC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40289AW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G40289RO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G40317YZ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G40330AQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40358EZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40463TJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40467RH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40475CA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40540DD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40558VT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40732RC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40734VV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40735XY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40791GU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40806JH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G40820FX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40849ON", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40963VD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41045PG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41063JS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41107EH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41182NJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G41274AJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41276XE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G41323XJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41331JX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G41489AY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41535JH", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G41611UG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G41658RK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41706FJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41731DX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41817BL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G41859XD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41865ZJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41878UL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41879EJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41937ED", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G41974MG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42023VI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42024LG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42097JO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42100WR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42173FT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42193NQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G42200QF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42295MA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42316LP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42324WH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42332HD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G42365XA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G42372YG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42413IW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42475PM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42477ZH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G42501PR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42530JA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42629JY", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G42648OU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42671TR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42673EN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42686NP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G42797TX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42823ZD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42826YI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42862VU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42866WF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42989XH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G43057CV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G43073RP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43131ZX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43157UW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G43230KT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43265RC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G43279WN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43290KL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43343WJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G43428WA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43433FA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43447HY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43460JV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43502GT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43505GC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G43549OX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43563XU", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G43610AB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43677TG", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G43814TV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43821JZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43901MM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43953LS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43997BS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44021SN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44132BD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44187XB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44202NB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44204WA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44207BG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44218WP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44306WZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44325XR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44326UJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44354BF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44362OF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44466VN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44536GS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G44647TG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44659VQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44780MA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44809MP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44909WI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G44923ZR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44992KB", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G44996SV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45000ZN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45045RU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45058LS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G45108QT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45189BK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45256SO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45258LH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45285RN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45293XC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45358WU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45367OE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G45442AV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45503YQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45523IL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G45590UB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45686NF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G45712IO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45734UD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45737TL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45756OH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45772IP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G45830EE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G45848EE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G45882FV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G45893DQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45924HV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46069XA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46081MO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46095FZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46208AF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46314PI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46328MP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G46394FV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46567HU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G46606FL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46627AU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46654QM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46750WJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G46764NJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46769UK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G46817RD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46923KZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46991EQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47000SB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47011KD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47027YN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47031UJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47122WR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47253VG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47260LO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47280ZG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47296XJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47351YJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47421EN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47527ML", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47533LE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47675LW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G47679MT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47699LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47736AN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47760AX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47795WI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47823SP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47927EW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47934SA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47936PQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48099DP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48105QY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48115MG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48202AJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48209XU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48265DV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48275DN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48296OD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48399DW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48417IK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48421GV", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G48435YB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48602PL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48648VZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48654YJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48698GX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48713OY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48727OO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48761VJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48779BH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48800IV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48802KI", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G48837AB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48872RO", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G48912RQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49035IR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49094OZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49106NZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49224NN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49236XV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49280JI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49282JI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49299ZV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49301OD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49317WN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49367OZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49380CI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49427FH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49462EF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49478IU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49481MA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49588KJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49601RS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49669MC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49768YY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49827WK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49830JU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49839AV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49861OY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49877FC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49923GC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49928PT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49980RY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49994RB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50008TR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50032MO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50036VV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50071YW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G50078RT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50112PT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G50171PU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50205RT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50240CR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G50293EM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50343XZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50383SB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50392AV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G50399JL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50432VO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50658WG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50735MY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50779LX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50785UU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50791ES", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G50817TZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50869YE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50901FO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G51004EY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G51007QO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G51013PJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51066TO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51117HW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G51243XN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51274LI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G51302HQ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G51347IO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51353BD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51358LW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51429SM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51448NK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51490BW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51497BL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51539FX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51683DQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51850PT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51880YN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51891DI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51947SS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G51956RJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51971TR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52021KR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52112MC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52153CS", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G52187WF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52231BF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G52238TO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52303GC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52333AW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G52351WJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G52360PJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52367SW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52393JB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G52497YI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52627IB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52637RD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52671WK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52674YL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G52793JJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G52801WH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52802XR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52932JK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52934AK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G52935OC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52965YW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52993TN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53000RQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53098FA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53108IN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53118DD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53149XZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53178HH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G53214SL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53219PO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53267EL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53342MA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53428UB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53460CX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53466SI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53471VF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G53520XD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53565EY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53605PF", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G53682XE", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G53709ZS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53718RP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53733BK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53743EA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53765TP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53767IX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53800FZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53802DN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53870ES", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53908VX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53931MC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53966GL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53975EE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53989JC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53996MC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54000LQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54170UG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54191CU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54274NA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54278AD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54299QJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54332AN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54341KJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54346KI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54394XF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54411RI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54547RU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54575IS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54577VQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54590FS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54627SJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54842UT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G54945YG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54961LR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55015QS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55036RV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55052CN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55067DH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G55084NR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55157XP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55327VV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55359NC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55396DW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55396WO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55452NM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55496WU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55601HX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55715VV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55758XD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55773UK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55785MZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56039JB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G56062OE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56063TJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56134WS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56271ML", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56341HY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56492JP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56505IP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56558EP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56586OT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56615HF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56748EO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G56784HS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56791SN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56830SM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56845UM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56869RQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56891ZN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56952FZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57001PH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57040DY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G57044IA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57052CH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57097HI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57112FM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57149GY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57204IX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57239MG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57390CG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57565PX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57607BW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G57611UV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57616BR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57626SM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G57627IF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57671LP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G57707WO", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G57729TT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57740WC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G57826CO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G57943ZV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57976DO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58039DV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G58281SK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58284AM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58454XF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58483GX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58561KE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58570WR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58585VB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58777MN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G58801CZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G58811EL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G58814UM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58816JP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58897VR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G58906EB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G58955OJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59128IS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59272DZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G59277TZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59356QU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59377NB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59430MJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59471TH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G59483DM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G59529PB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G59566HR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59622PB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G59626FR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59679CG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G59683UM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G59784AY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G59922XB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G59942FB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G60002AN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60065IV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60091HT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60137DJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60199KP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60264PM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60284TY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G60297HX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60320IS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60358PW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G60390SH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60512QS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60534NQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60546VQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G60663ZP", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G60667OL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60704KF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60708JN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G60721MK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G60947HQ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G60956VN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G60972PW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G61055SH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61059KD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G61071ZB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61096LS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61133SM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61158LP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61231NM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61274OD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61278VW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61357GY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61400EK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61431VC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G61443KH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G61500DM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61519GA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61542DY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61627IG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61684ET", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61718WP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61768GE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61794OV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G61819UR", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G61842MB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61862FV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G61956VN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G61958FQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G61963QJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G61983AR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62088FQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62187QU", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G62232KJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62254QB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G62260EJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62270QG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62316AI", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G62339AO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G62360SN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G62364JZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62415QZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62480RR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62489DB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62710LV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62720NT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62738GM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62781GE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62828UD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62837IG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62846AZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62880PC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G62881HL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G62998IM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G63019NZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G63046OH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G63075AF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63100TS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63111RL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63176TU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63378BN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63480NF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63517NT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G63561NG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G63634EO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G63708BZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63710WS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63782AK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63796IY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G63807DH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G63831UM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G63974SF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64001CI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64058SS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G64083HN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64126JS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64139XJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G64140DB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64188CP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64196PV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G64239AX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64257JI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G64321QR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G64477EK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64574OD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64592EN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G64661YG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64697JB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G64713KE", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G64823DM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G64863JJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G64900ET", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G64968YN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65186SE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G65219TP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65272MH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65365UP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G65419YA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65463BF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65464VJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G65515HD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G65516CQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G65550TC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65603XA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65645WO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65683ZU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65731WH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65779NI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65780VF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65855MN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G65937DK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65968DD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66006LF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66031SE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66122ZT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G66133JV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66152NM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G66265KN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G66281YY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G66313YW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66341WM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66344IV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G66348MF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G66364XV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G66408GD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G66495KL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66733MH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66751BK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G66770EM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G66807CI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G66987MV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G66992XO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G66998OZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67140YI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G67167QM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G67289UM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G67308WB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67358EC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G67452TN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67499DD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67555IZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67556VZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G67610IY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G67634LE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67662PT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G67761EU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G67850XJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G67888MA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G67915MO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G67917AQ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G67942CH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G67964ZP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G67966YH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G67996UU", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G68045UG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68177CS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68189FR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68316HS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G68325JZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68357WI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68395LV", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G68405FW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68427HB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68429EK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G68474GP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68572OG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68607FX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68639SS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G68641SL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68654BA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68659PK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68676CY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68691YG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68694NT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68722WQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68778FY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68891KC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G68901IK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G68946DB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G68946ST", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G68957QP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G68959TR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G68979CW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69077TN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G69098HL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G69148CH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G69299PB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69315KN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69332JU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69384SX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G69457SW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G69485SE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69655CC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69704YD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G69736FR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69747YU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G69956XT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69957XS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G69964CA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69983FE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G69991JV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G69994YJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70036UQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70052MF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G70081QS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70193YQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70229DF", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G70258ML", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70408IO", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G70486AZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G70555UC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G70584KM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G70594XD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G70602JC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G70634FB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G70640QN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70647ZZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G70695OC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70732DF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70743LN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70812GK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70819AR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G70856RV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G70945OS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71013KY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71108TK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71145QW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71226JJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G71255YR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G71265RV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G71272JH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71293OQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71295UC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71323VY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71333AK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71380NP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71457DK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71562CD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71602GO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71606HZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71626LI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71670JD", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G71754ZD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71797UT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G71850TH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71865NO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G71869FP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71885XA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71922QL", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G71923IX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71943TB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G71944BB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G72043OX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G72073OC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G72108NZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72108VJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G72121YB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72233LJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G72294VT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72335YL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72356JA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G72645FS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G72676IN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G72698LT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72703LD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72718TT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G72730KA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72758KY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G72771HB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G72821WX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72854TO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G72902CL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G72905QH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G72937LG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73057DA", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G73063NN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73092FQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73095MB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73150IZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73161WI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73181DZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73224TY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73233BD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73266RH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73302KW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73312RB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G73367DT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73370VW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73489KE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73510FE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73539WK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73605IH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73643TI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G73849MH", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G73868PD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G73907HE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G73925VP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G73946CG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G73964QN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74058GD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74083UN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74111MH", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G74242UP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74246AM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G74256AQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74324QB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74325TG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74362TD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G74372YP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G74388HZ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G74396ZF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74409IY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74459BD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G74465ET", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G74479RH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74483WI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G74514LS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74517GR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74554WD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74574VX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74594TP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74645FT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74712KJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G74733FS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74752PS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74764RU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74782AW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74836FN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74851KS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74864OW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G74891FV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G74910NC", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G74916CC", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G74922NM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G74961IU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75027OL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75039HL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75041IL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75064IS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75068EM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75073DE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75140UB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75143LK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75159YA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75185KR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G75237AB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75299EE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75345ZM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G75359YM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75412QZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75469AF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75472NY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75515IJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75544YR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75554MB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75595FQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75596TV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75601RG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75632DB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G75782XF", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G75851WY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G75860QV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G75886KR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75899KQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G75937YG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G76004QW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76008KR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G76020SE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76057YA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76087MP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76107TS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76130EW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76230IU", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G76241TN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G76283SF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G76297WR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76323CE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G76336UP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76397RF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G76422GC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G76459TW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G76518ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76519VT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76528ZS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G76583MP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76599ZU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76802ZU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G76807JB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G76824BS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G76887WW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G76965FZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76975IV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G76980RS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77018RW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77136ZM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77225CQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77253ZO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G77263LH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77281QV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77371VZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77408FM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77445IQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77467SI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G77498XG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77507FD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77541VZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77572QA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77696JC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G77700FV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77859TT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G77887RB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77903BI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G77922WZ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G77995GQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G78034VF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78071LY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78085XU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G78098WY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78211AM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78255XL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78300IO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78322UH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G78368CZ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G78399ZX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78454ZT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G78497UW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78603IZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G78625LN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G78656QZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78759UO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78768UQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78786BU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G78838PJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78890BA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78903AJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G78956IC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G78961ZT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79014VD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79051IT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G79077OL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79088TX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79089IH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G79115EW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G79198BK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79198HM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79345TW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79349EV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79388JI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79469HB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79508LR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79523YN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G79591YI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79690UD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79745PG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79801ZZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G79815MA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G79967SA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G80005YU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G80030LD", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G80031DC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G80064DH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G80098ET", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80099PR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80180SI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G80291NS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G80357RX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G80368BJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80398VF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80439QE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G80578OK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80678MA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G80685EK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80733LA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G80748AR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G80759CD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G80848DN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81101GO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81150TA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81157IG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81180VS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G81294QU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81324MV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81326IN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G81331ZW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81348LS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81353SK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81392TU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81397TP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81424HL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G81430ON", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81436EU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81456UA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81499XS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G81617NU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81654JV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81707CP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G81728BG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G81795JQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G81804CZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81898FC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81939AD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G81999RZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82126PQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82138AT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82159VB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82188BV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G82233UN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G82261XI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82350CE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82413XV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G82420AC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82494AO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G82526LU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82549MI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G82557QP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G82659LR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G82665EP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G82680EC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82719GT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G82753OZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82805YZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82861UH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G82907NZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G82933ZI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83003BM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83042OA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83153LR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83159ZN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83194SP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83211YC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83238RE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83354CN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G83364CO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83374IQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G83393QM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83416NA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83423JP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83432MQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G83433HW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83437IN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G83499UD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83538KX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G83555KF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83682YJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83689NL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G83705SY", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G83710OS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83864PP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83879QG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G83880IN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G83945MQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84121WW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G84122EI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84198AN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84222WV", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G84228XL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84260SO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84316BO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84377QA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84423SZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G84440YT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G84441GS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84454HO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84456HG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84718MC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84754BQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84817HK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G84838NP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85075CJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G85085MS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85100QD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G85102OH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G85116ZD", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G85196GZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85207ZD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G85219EY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G85250EQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85287WC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85304RG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G85317AM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G85450ZF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85453OX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85471HV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85501TK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85526SO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85530IT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G85626MC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G85627UH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85657EG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85702AE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85723NH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G85767HW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85785GS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85790MP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85856NQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G85890MM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G85891RL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85893DL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86005HP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86083OF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86120MH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G86135ET", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86266CW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G86282KU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86445KR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G86471BL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86476SQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86477WA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G86490WA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G86517XT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G86522OD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G86546JM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86563OV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G86632ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G86646KC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86713OE", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G86731GD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86766IO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86782SC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86788TP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86912FM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86912UU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G86928UZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G86942VM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G86997OW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87022AY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87140NS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87158OD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87202LK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G87290LM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87299HQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87402BD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87422CM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87505EW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87513SK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87544CM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87558RR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G87598ZK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G87632FZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G87639RD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87641EM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87642KR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G87649YD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87721BR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G87777GG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87854BA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87888LG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87918MM", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G87924KN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87937HR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G87941OV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G88030NF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88038QS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G88097CV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88176UG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88289CZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88304RN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G88310CR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88362BO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88370LG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88651GV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G88711NV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G88757PX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88807WA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G88827CD", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G88844KJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G88876JD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G88885UE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88897CI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G88963CA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G89001GU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G89038KG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89091LQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G89119YB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89168IV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89168LM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89177YT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G89282EC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89451OH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G89455DQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89532UK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89617FK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G89620UQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G89623PK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G89663TB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89669IB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G89685ZW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89722NR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89794YL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89814XX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89841WS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G89845CN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G89891DR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G89955WO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G90033AN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G90125QJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90172SA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G90223PU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90363CW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G90443NH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G90443WR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G90481BK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G90484GL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G90505XK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90556HS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G90601SD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90618SW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G90621CY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90651NI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G90670ZD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G90719YN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G90766ZI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G90913OZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90941ZH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90947VT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G90999CW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G91022KO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G91023GB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G91060UC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91074JT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91103IY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91151XY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91180QG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G91215YF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91223HN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91405EV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91443KB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G91452KP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91513OX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91550OH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91574ZW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91590EX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91591WO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91611ZT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91616GP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91623TN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G91650DK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G91676UJ", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G91827TX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G91832SW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91884EQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91959FP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G91972CK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G91977ZB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92008YL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92034PX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92067KW", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G92129PT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92143CS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92172MH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G92177FO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92186BR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92233MO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92279JC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92345EN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92372TK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92381BV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92575UZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92602UC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92607UN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G92696SZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92697XR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92744LQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92749SJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G92760YI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92779QW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92782XB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92918JF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G92940AF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92970XQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G92985IP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93058GD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93148GC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93154HG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93193OD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G93204KY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93237CR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G93266DC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93317NJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93385YJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G93396XX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93405VL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93464IM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93500PH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93600HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93711GC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G93789YX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G93867TX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G93876QO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93926FR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93934MI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G93943KM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G94027HD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G94045IP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94152LN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G94163JU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94232LU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94286MI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94373HA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G94437IW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94483MH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G94506PU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G94547KR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G94827FB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G94838KN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G95010JN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95028EM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95030RK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95061TN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G95147ON", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95151DV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95198OA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G95271EU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95298UR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95375WT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G95415LS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95447BJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95499ZQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95511KK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95578GP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95617FJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G95627ZE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95640VH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95710IM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G95738WX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95782RB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95800DS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95801CS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G95842MF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G95861WO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95898GD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G95901MC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G95944OM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G95998QK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G96014TN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G96060VZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G96091LW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G96127PC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G96133SC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G96137SX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G96279GC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G96293XW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96391AF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96400HO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G96489SM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96547KG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G96587VR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G96671TO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G96680QM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G96743TG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G96832KC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G96852SM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G96863JM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G96866DI", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G96881RJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G96886RH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G96886RU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G96893BL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G96930UE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G96953KB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G96988DW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97067GW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97078FW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97093EP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97100OV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G97105ZG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97201CX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G97390YU", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G97392KG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G97487DU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G97545UW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97564QK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G97570UX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97628LQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97673HZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G97693ZT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97723JK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97793YM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G97814YJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G97846KQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G97885PU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G97904TF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G97910HZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98030BR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98093OC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98114SN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98131ZY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98140IX", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G98190RD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98204RT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G98217YG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98243KG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98348QS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G98355BE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G98415RH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G98453EN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98552UD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G98566CZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98590PE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98601DU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G98602UY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G98668GO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98705PP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98732QD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98739YW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G98803VP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98826ZZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G98891YJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G98900RH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G98950NS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G98961TI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99003YY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99035PG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99066II", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99067GT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G99135AC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G99220PE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99331MG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G99368BW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99382AP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99403CC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99420ZQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G99468UC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99476KG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99493HM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G99567WP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99607LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99647DZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99651QK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99676LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99770NO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99777VA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99829YW", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G99902FH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99927HL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99952ON", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G99954ZJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G99996FL", "type": "N-linked", "subtype": "Core-fucosylated" } ], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 249, "end_pos": 251 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 405, "end_pos": 407 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA16-1", "uniprot_ac": "A0AAA9SA16", "uniprot_id": "A0AAA9SA16_BOVIN", "mass": { "chemical_mass": 88049.0, "monoisotopic_mass": 88049.0 }, "refseq": {}, "gene_names": [ { "name": "XRRA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SA16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16" } ] } ], "protein_names": [ { "name": "X-ray radiation resistance-associated protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SA16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in the response of cells to X-ray radiation.", "evidence": [ { "database": "UniProtKB", "id": "E1BMB0", "url": "https://www.uniprot.org/uniprotkb/E1BMB0#function" }, { "database": "UniProtKB", "id": "ARBA00056245", "url": "https://www.uniprot.org/uniprotkb/ARBA00056245#function" }, { "database": "UniProtKB", "id": "F1MD61", "url": "https://www.uniprot.org/uniprotkb/F1MD61#function" }, { "database": "UniProtKB", "id": "A0AAA9SA16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16#function" }, { "database": "UniProtKB", "id": "A0AAA9T6L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XRRA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16", "locus": { "chromosome": "15", "start_pos": 54150612, "end_pos": 54223182, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006610", "url": "https://www.ensembl.org/id/ENSBTAG00000006610" } ] } } ], "crossref": [ { "id": "A0AAA9SA16", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006610", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006610", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "369019", "url": "https://www.ncbi.nlm.nih.gov/gene/369019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BMB0", "url": "https://www.orthodb.org/?gene=E1BMB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22710", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22710", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22710:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22710:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SA16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMB0", "url": "https://www.uniprot.org/uniprotkb/E1BMB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMB0-1", "url": "https://www.uniprot.org/uniprotkb/E1BMB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD61", "url": "https://www.uniprot.org/uniprotkb/F1MD61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD61-1", "url": "https://www.uniprot.org/uniprotkb/F1MD61-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAELYKLDDGKPHLSNCFPAKNLLRTPEEAGRGHWLVARKGGLKKKPKNVAETTAEGQEGQKVSFEVEGKKGSRQENQVDTPGHMLDLAFLLKHHCVKDPSDLCSINVSGLKFSKAKEKDFKHFNSVIYINASENLLPLEAFHTFPVLKELELAFNGIKTVYVKYGDFKSLEFLDLSFNSLTAEAICDLGILPHLRVLLLTGNGLTSLPPSLAVAEQEASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSETTKVCALPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTMEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDPTFVEPKGIQKNAQALQHMLKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRWPSISMESCARKRQRIPSCCQIW", "length": 778, "header": "tr|A0AAA9SA16-1|A0AAA9SA16_BOVIN Isoform 1 of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=4 SV=1 CANONICAL=A0AAA9SA16-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16/entry#A0AAA9SA16-1", "sequence": { "sequence": "MASAELYKLDDGKPHLSNCFPAKNLLRTPEEAGRGHWLVARKGGLKKKPKNVAETTAEGQEGQKVSFEVEGKKGSRQENQVDTPGHMLDLAFLLKHHCVKDPSDLCSINVSGLKFSKAKEKDFKHFNSVIYINASENLLPLEAFHTFPVLKELELAFNGIKTVYVKYGDFKSLEFLDLSFNSLTAEAICDLGILPHLRVLLLTGNGLTSLPPSLAVAEQEASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSETTKVCALPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTMEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDPTFVEPKGIQKNAQALQHMLKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRWPSISMESCARKRQRIPSCCQIW", "length": 778, "header": "tr|A0AAA9SA16-1|A0AAA9SA16_BOVIN Isoform 1 of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=4 SV=1 CANONICAL=A0AAA9SA16-1" }, "locus": { "chromosome": "15", "start_pos": 54213757, "end_pos": 54151616, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109805.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109805.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082923.1" } ] } }, { "isoform_ac": "A0AAA9SC64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16/entry#A0AAA9SC64-1", "sequence": { "sequence": "MLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSEIAKEDAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTMEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDPTFVEPKGIQKNAQALQHMLKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRSVFGTTAPPQARPALSGSQPKLGRFLEFMDEFYQEPTASDLKG", "length": 515, "header": "tr|A0AAA9SC64-1|A0AAA9SC64_BOVIN Computationally mapped isoform of X-ray radiation resistance associated 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=4 SV=1 CANONICAL=A0AAA9SA16-1" }, "locus": { "chromosome": "15", "start_pos": 54182704, "end_pos": 54155684, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133652.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133652.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079821.1" } ] } }, { "isoform_ac": "A0AAA9T6L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16/entry#A0AAA9T6L9-1", "sequence": { "sequence": "MASAELYKLDDGKPHLSNCFPAKNLLRTPEEGRGHWLVARKGGLKKKPKNVAETTAEGQEGQKVSFEVEGKKGSRQENQVDTPGHMLDLAFLLKHHCVKDPSDLCSINAKEKDFKHFNSVIYINASENLLPLEAFHTFPVLKELELAFNGIKTVYVKYGDFKSLEFLDLSFNSLTAEAICDLGILPHLRVLLLTGNGLTSLPPSLAVAEQEASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTGVPPLLKSFLQERLGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTMEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDPTFVEPKGIQKNAQALQHMLKHPLVYRSSKPRLDTLQKHYVPKEKREPSCASGQNSGW", "length": 595, "header": "tr|A0AAA9T6L9-1|A0AAA9T6L9_BOVIN Computationally mapped isoform of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=4 SV=1 CANONICAL=A0AAA9SA16-1" }, "locus": { "chromosome": "15", "start_pos": 54213757, "end_pos": 54155899, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092229.1" } ] } }, { "isoform_ac": "E1BMB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16/entry#E1BMB0-1", "sequence": { "sequence": "MASAELYKLDDGKPHLSNCFPAKNLLRTPEEGRGHWLVARKGGLKKKPKNVAETTAEGQEGQKVSFEVEGKKGSRQENQVDTPGHMLDLAFLLKHHCVKDPSDLCSINVSGLKFSKAKEKDFKHFNSVIYINASENLLPLEAFHTFPVLKELELAFNGIKTVYVKYGDFKSLEVSWREASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSETTKVCALPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTMEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDPTFVEPKGIQKNAQALQHMLKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRSVFGTTAPPQARPALSGSQPKLGRFLEFMDEFYQEPTASDLKG", "length": 756, "header": "tr|E1BMB0-1|A0AAA9SA16_BOVIN Computationally mapped isoform of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=4 SV=3 CANONICAL=A0AAA9SA16-1" }, "locus": { "chromosome": "15", "start_pos": 54213757, "end_pos": 54155684, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061445.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061445.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053271.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053271.3" } ] } }, { "isoform_ac": "F1MD61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16/entry#F1MD61-1", "sequence": { "sequence": "MASAELYKLDDGKPHLSNCFPAKNLLRTPEEAGRGHWLVARKGGLKKKPKNVAETTAEGQEGQKVSFEVEGKKGSRQENQVDTPGHMLDLAFLLKHHCVKDPSDLCSINVSGLKFSKAKEKDFKHFNSVIYINASENLLPLGLCAHREASVTSLTTKRYILRFPALETLMLDDNKLSNPNCFVSLAGLKRLKKLSLDQNRIFRIPYLQQVQLRDGSGDWVGGRGSPRKQPQSMLQSKSWIYEASDDQPDYTILPMKKDVDRTEVVFSSYPGFSTSETTKVCALPPIFEILPVKSLKARNQTLAPPFPELRYLSLAYNKIAKEDAILPVALFPSLCELIFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKAKHHILMPRKDSRKVKTQVPKVPKQPMILPHPSVMIKSPSKEMLESEAELTMEPPPTKTISVEREMPIEGLGGPPMPHRTFVPLPPICSDSTVHSEETSPRSDAAGRLSADQLSDEDTKSTESIFLTQVSGLSSSIFQRDDSEIKEKEQRPPSTAPREAKRTQKKPPSASFPRKYHGYEELLTAKPDPTFVEPKGIQKNAQALQHMLKHPLVYRSSKPRLDTLQKHYVPKEKRTRRIPVPPRRKTRAQLLDDILIRMRDTQNITEAPLGAVLRQRTEQRLVNQKQFLEAKKLLKEFRARYRRLVRCSLRSVFGTTAPPQARPALSGSQPKLGRFLEFMDEFYQEPTASDLKG", "length": 726, "header": "tr|F1MD61-1|A0AAA9SA16_BOVIN Computationally mapped isoform of X-ray radiation resistance-associated protein 1 OS=Bos taurus OX=9913 GN=XRRA1 PE=4 SV=4 CANONICAL=A0AAA9SA16-1" }, "locus": { "chromosome": "15", "start_pos": 54213757, "end_pos": 54155684, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008701.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008701.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008701.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008701.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 133, "end_pos": 135 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 708, "end_pos": 710 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA39-1", "uniprot_ac": "A0AAA9SA39", "uniprot_id": "A0AAA9SA39_BOVIN", "mass": { "chemical_mass": 68955.0, "monoisotopic_mass": 68955.0 }, "refseq": {}, "gene_names": [ { "name": "NEPRO", "type": "recommended", "evidence": [ { "id": "A0AAA9SA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ] } ], "protein_names": [ { "name": "Nucleolus and neural progenitor protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEPRO", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39", "locus": { "chromosome": "1", "start_pos": 57724643, "end_pos": 57741141, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005723", "url": "https://www.ensembl.org/id/ENSBTAG00000005723" } ] } } ], "crossref": [ { "id": "A0AAA9SA39", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005723", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005723", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516064", "url": "https://www.ncbi.nlm.nih.gov/gene/516064", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516064", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516064", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N1N1", "url": "https://www.orthodb.org/?gene=F1N1N1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34761", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34761", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34761:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34761:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1N1", "url": "https://www.uniprot.org/uniprotkb/F1N1N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1N1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1N1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDSAQGPSPAPAPPFALYLPVTSTHLPSYGPSTWSGLAPPLPLPLLPPKMATLLPGPEPWNRVRIPKAGSRSAVTVQNPDTALDLCIAAIIKECCRITLSLKSRTLDAETDVLCAILYSNHNRMGRHKPHLALRQVEQCLKRLKNMNLEGSIQDLSESFSSNENQPINTKACVIPSQPVVELVLMKILGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKDVLKRLVSLYEPLFGLLQEVSRIQPLPYFKGFTFPSDIVEFLGEPYFEVFKKKMPTAFVAKGVTKLLNKLFLTKEQSQRSGEETLLRISEKAKQMKINIQNNMDLGQPVKSKKILKEKSSEFDVRAFCKQLKQKAIQEKSFEFKYSPSKLKATKHSSQKAIGTPCVKSLVQRFREAETFTQLSEEIQMAILWCRSKKLKAQTAFLGNKLLKSNRLKHVEAQGSSLPKKLQCIKTSICNCLLHGLGMKTSKHHLRQRRSQNKFSLKGRKQRKLQSTLLKEIQQPPQGTQSATDVIKGRLSDSTVRRTDLYPNNKQVNRRVSNPVIQTKETQTHEKLTESNENKTDSWTVMQGNKHNTSGSTKETDDIDDIFALMGV", "length": 612, "header": "tr|A0AAA9SA39-1|A0AAA9SA39_BOVIN Isoform 1 of Nucleolus and neural progenitor protein OS=Bos taurus OX=9913 GN=NEPRO PE=4 SV=1 CANONICAL=A0AAA9SA39-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39/entry#A0AAA9SA39-1", "sequence": { "sequence": "MKDSAQGPSPAPAPPFALYLPVTSTHLPSYGPSTWSGLAPPLPLPLLPPKMATLLPGPEPWNRVRIPKAGSRSAVTVQNPDTALDLCIAAIIKECCRITLSLKSRTLDAETDVLCAILYSNHNRMGRHKPHLALRQVEQCLKRLKNMNLEGSIQDLSESFSSNENQPINTKACVIPSQPVVELVLMKILGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKDVLKRLVSLYEPLFGLLQEVSRIQPLPYFKGFTFPSDIVEFLGEPYFEVFKKKMPTAFVAKGVTKLLNKLFLTKEQSQRSGEETLLRISEKAKQMKINIQNNMDLGQPVKSKKILKEKSSEFDVRAFCKQLKQKAIQEKSFEFKYSPSKLKATKHSSQKAIGTPCVKSLVQRFREAETFTQLSEEIQMAILWCRSKKLKAQTAFLGNKLLKSNRLKHVEAQGSSLPKKLQCIKTSICNCLLHGLGMKTSKHHLRQRRSQNKFSLKGRKQRKLQSTLLKEIQQPPQGTQSATDVIKGRLSDSTVRRTDLYPNNKQVNRRVSNPVIQTKETQTHEKLTESNENKTDSWTVMQGNKHNTSGSTKETDDIDDIFALMGV", "length": 612, "header": "tr|A0AAA9SA39-1|A0AAA9SA39_BOVIN Isoform 1 of Nucleolus and neural progenitor protein OS=Bos taurus OX=9913 GN=NEPRO PE=4 SV=1 CANONICAL=A0AAA9SA39-1" }, "locus": { "chromosome": "1", "start_pos": 57741065, "end_pos": 57725647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080293.1" } ] } }, { "isoform_ac": "A0AAA9SDY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39/entry#A0AAA9SDY6-1", "sequence": { "sequence": "MALRLLDLCIAAIIKECCRITLSLKSRTLDAETDVLCAILYSNHNRMGRHKPHLALRQVEQCLKRLKNMNLEGSIQDLSESFSSNENQPINTKACVIPSQPVVELVLMKILGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKDVLKRLVSLYEPLFGLLQEVSRIQPLPYFKGFTFPSDIVEFLGEPYFEVFKKKMPTAFVAKGVTKLLNKLFLTKEQSQRSGEETLLRISEKAKQMKINIQNNMDLGQPVKSKKILKEKSSEFDVRAFCKQLKQKAIQEKSFEFKYSPSKLKATKHSSQKAIGTPCVKSLVQRFREAETFTQLSEEIQMAILWCRSKKLKAQTAFLGNKLLKSNRLKHVEAQGSSLPKKLQCIKTSICNCLLHGLGMKTSKHHLRQRRSQNKFSLKGRKQRKLQSTLLKEIQQPPQGTQSATDVIKGRLSDSTVRRTDLYPNNKQVNRRVSNPVIQTKETQTHEKLTESNENKTDSWTVMQGNKHNTSGSTKETDDIDDIFALMGV", "length": 534, "header": "tr|A0AAA9SDY6-1|A0AAA9SDY6_BOVIN Computationally mapped isoform of Nucleolus and neural progenitor protein OS=Bos taurus OX=9913 GN=NEPRO PE=4 SV=1 CANONICAL=A0AAA9SA39-1" }, "locus": { "chromosome": "1", "start_pos": 57740277, "end_pos": 57725647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115386.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115386.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081802.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081802.1" } ] } }, { "isoform_ac": "A0AAA9SQC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39/entry#A0AAA9SQC9-1", "sequence": { "sequence": "MSMESVMPSKHLILCRPLLLLPSIFPNIRVFSNESALHIRWPKYWSFSFNTSPSNEHPGLISFRMDWLDLLAVQDLCIAAIIKECCRITLSLKSRTLDAETDVLCAILYSNHNRMGRHKPHLALRQVEQCLKRLKNMNLEGSIQDLSESFSSNENQPINTKACVIPSQPVVELVLMKILGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKDVLKRLVSLYEPLFGLLQEVSRIQPLPYFKGFTFPSDIVEFLGEPYFEVFKKKMPTAFVAKGVTKLLNKLFLTKEQSQRSGEETLLRISEKAKQMKINIQNNMDLGQPVKSKKILKEKSSEFDVRAFCKQLKQKAIQEKSFEFKYSPSKLKATKHSSQKAIGTPCVKSLVQRFREAETFTQLSEEIQMAILWCRSKKLKAQTAFLGNKLLKSNRLKHVEAQGSSLPKKLQCIKTSICNCLLHGLGMKTSKHHLRQRRSQNKFSLKGRKQRKLQSTLLKEIQQPPQGTQSATDVIKGRLSDSTVRRTDLYPNNKQVNRRVSNPVIQTKETQTHEKLTESNENKTDSWTVMQGNKHNTSGSTKETDDIDDIFALMGV", "length": 602, "header": "tr|A0AAA9SQC9-1|A0AAA9SQC9_BOVIN Computationally mapped isoform of Nucleolus and neural progenitor protein OS=Bos taurus OX=9913 GN=NEPRO PE=4 SV=1 CANONICAL=A0AAA9SA39-1" }, "locus": { "chromosome": "1", "start_pos": 57738919, "end_pos": 57725647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105874.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105874.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087572.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087572.1" } ] } }, { "isoform_ac": "F1N1N1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39/entry#F1N1N1-1", "sequence": { "sequence": "MDWLDLLAVQDLCIAAIIKECCRITLSLKSRTLDAETDVLCAILYSNHNRMGRHKPHLALRQVEQCLKRLKNMNLEGSIQDLSESFSSNENQPINTKACVIPSQPVVELVLMKILGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKDVLKRLVSLYEPLFGLLQEVSRIQPLPYFKGFTFPSDIVEFLGEPYFEVFKKKMPTAFVAKGVTKLLNKLFLTKEQSQRSGEETLLRISEKAKQMKINIQNNMDLGQPVKSKKILKEKSSEFDVRAFCKQLKQKAIQEKSFEFKYSPSKLKATKHSSQKAIGTPCVKSLVQRFREAETFTQLSEEIQMAILWCRSKKLKAQTAFLGNKLLKSNRLKHVEAQGSSLPKKLQCIKTSICNCLLHGLGMKTSKHHLRQRRSQNKFSLKGRKQRKLQSTLLKEIQQPPQGTQSATDVIKGRLSDSTVRRTDLYPNNKQVNRRVSNPVIQTKETQTHEKLTESNENKTDSWTVMQGNKHNTSGSTKETDDIDDIFALMGV", "length": 538, "header": "tr|F1N1N1-1|A0AAA9SA39_BOVIN Computationally mapped isoform of Nucleolus and neural progenitor protein OS=Bos taurus OX=9913 GN=NEPRO PE=4 SV=4 CANONICAL=A0AAA9SA39-1" }, "locus": { "chromosome": "1", "start_pos": 57738727, "end_pos": 57725647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007523.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007523.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007523.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007523.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516064", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516064", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "pmid": "" }, { "name": "ribonuclease MRP complex", "id": "GO:0000172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000172", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "pmid": "" }, { "name": "positive regulation of Notch signaling pathway", "id": "GO:0045747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045747", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA39" }, { "id": "PF14780", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14780" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolus and neural progenitor protein-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 251, "start_aa": "Trp", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 578, "end_pos": 580 }, { "start_pos": 592, "end_pos": 594 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5V8-1", "uniprot_ac": "A0AAA9S5V8", "uniprot_id": "A0AAA9S5V8_BOVIN", "mass": { "chemical_mass": 33776.0, "monoisotopic_mass": 33776.0 }, "refseq": {}, "gene_names": [ { "name": "RGR", "type": "recommended", "evidence": [ { "id": "A0AAA9S5V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ] } ], "protein_names": [ { "name": "RPE-retinal G protein-coupled receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9S5V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8#function" }, { "database": "UniProtKB", "id": "ARBA00057095", "url": "https://www.uniprot.org/uniprotkb/ARBA00057095#function" }, { "database": "UniProtKB", "id": "A0AAA9TPJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPJ6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8", "locus": { "chromosome": "28", "start_pos": 39227371, "end_pos": 39202110, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015681", "url": "https://www.ensembl.org/id/ENSBTAG00000015681" } ] } } ], "crossref": [ { "id": "A0AAA9S5V8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5V8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15072", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15072", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RWSSRAAPAPAACRASQRPRRGRSRQLCSQPGGPSTPRSRSALSGLSLNILTILSFCKTPELRTPSHLLVLSLALADSGISLNALVAATSSLLRRWPYGSEGCQAHGFQGFVTALASICSSAAVAWGRYHHFCTRSRLDWNTAVSLVFFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSRGDRNFTSFLFTMAFFNFLLPLFITVVSYRLMEQKLGKTSRPPVNTVLPARTLLLGWGPYALLYLYATIADATSISPKLQMVPALIAKAVPTVNAMNYALGSEMVHRGIWQCLSPQRREHSREQ", "length": 306, "header": "tr|A0AAA9S5V8-1|A0AAA9S5V8_BOVIN Isoform 1 of RPE-retinal G protein-coupled receptor OS=Bos taurus OX=9913 GN=RGR PE=4 SV=1 CANONICAL=A0AAA9S5V8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8/entry#A0AAA9S5V8-1", "sequence": { "sequence": "RWSSRAAPAPAACRASQRPRRGRSRQLCSQPGGPSTPRSRSALSGLSLNILTILSFCKTPELRTPSHLLVLSLALADSGISLNALVAATSSLLRRWPYGSEGCQAHGFQGFVTALASICSSAAVAWGRYHHFCTRSRLDWNTAVSLVFFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSRGDRNFTSFLFTMAFFNFLLPLFITVVSYRLMEQKLGKTSRPPVNTVLPARTLLLGWGPYALLYLYATIADATSISPKLQMVPALIAKAVPTVNAMNYALGSEMVHRGIWQCLSPQRREHSREQ", "length": 306, "header": "tr|A0AAA9S5V8-1|A0AAA9S5V8_BOVIN Isoform 1 of RPE-retinal G protein-coupled receptor OS=Bos taurus OX=9913 GN=RGR PE=4 SV=1 CANONICAL=A0AAA9S5V8-1" }, "locus": { "chromosome": "28", "start_pos": 39226846, "end_pos": 39202143, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104167.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104167.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080602.1" } ] } }, { "isoform_ac": "A0AAA9TPJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8/entry#A0AAA9TPJ6-1", "sequence": { "sequence": "MAESGTLPTGFGELEVLAVGTVLLVEALSGLSLNILTILSFCKTPELRTPSHLLVLSLALADSGISLNALVAATSSLLRRWPYGSEGCQAHGFQGFVTALASICSSAAVAWGRYHHFCTRSRLDWNTAVSLVFFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSRGDRNFTSFLFTMAFFNFLLPLFITVVSYRLMEQKLGKTSRPPVPALIAKAVPTVNAMNYALGSEMVHRGIWQCLSPQRREHSREQ", "length": 253, "header": "tr|A0AAA9TPJ6-1|A0AAA9TPJ6_BOVIN Computationally mapped isoform of RPE-retinal G protein-coupled receptor OS=Bos taurus OX=9913 GN=RGR PE=4 SV=1 CANONICAL=A0AAA9S5V8-1" }, "locus": { "chromosome": "28", "start_pos": 39226846, "end_pos": 39216775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096382.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096382.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100326.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100326.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "pmid": "" }, { "name": "photoreceptor activity", "id": "GO:0009881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "pmid": "" }, { "name": "phototransduction", "id": "GO:0007602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5V8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 280, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S920-1", "uniprot_ac": "A0AAA9S920", "uniprot_id": "A0AAA9S920_BOVIN", "mass": { "chemical_mass": 37631.0, "monoisotopic_mass": 37631.0 }, "refseq": {}, "gene_names": [ { "name": "FAHD2A", "type": "recommended", "evidence": [ { "id": "A0AAA9S920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" } ] } ], "protein_names": [ { "name": "Fumarylacetoacetate hydrolase domain containing 2A", "type": "synonym", "evidence": [ { "id": "A0AAA9S920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S920", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAHD2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920", "locus": { "chromosome": "11", "start_pos": 2165623, "end_pos": 2153786, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011553", "url": "https://www.ensembl.org/id/ENSBTAG00000011553" } ] } } ], "crossref": [ { "id": "A0AAA9S920", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S920", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051121", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051121", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42796", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42796", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42796:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42796:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S920", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S920-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAQ6J790", "url": "https://www.uniprot.org/uniprotkb/A0AAQ6J790", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAQ6J790-1", "url": "https://www.uniprot.org/uniprotkb/A0AAQ6J790-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGSSGRRLLTTVLQAQRWPFQPSRNMRLVQFQAPHLAGPHLGLESGNGGGVIDLNAFEPTLPKTMVEFLEQGEATLSVVRRALATQLPVLPRSEVTFLAPVTRPDKVVCVGMNYADHCREQNVPVPKEPIIFSKFASAIVGPYDNIILPPESQEVDWEVELAVVIGKRGKYIKATDAMAHVAGFTVAHDVSARDWQMGRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVNGEVMQSSNTNQMVFKTEELITWVSQFVTLYPGDIILTGTPPGVGVFRKPPVFLKKGDEVQCEIEELGVIINKDVFPGVRGHSHPVGKESRYIHMITPEKQC", "length": 341, "header": "tr|A0AAA9S920-1|A0AAA9S920_BOVIN Isoform 1 of Fumarylacetoacetate hydrolase domain containing 2A OS=Bos taurus OX=9913 GN=FAHD2A PE=3 SV=1 CANONICAL=A0AAA9S920-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S920-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920/entry#A0AAA9S920-1", "sequence": { "sequence": "MLGSSGRRLLTTVLQAQRWPFQPSRNMRLVQFQAPHLAGPHLGLESGNGGGVIDLNAFEPTLPKTMVEFLEQGEATLSVVRRALATQLPVLPRSEVTFLAPVTRPDKVVCVGMNYADHCREQNVPVPKEPIIFSKFASAIVGPYDNIILPPESQEVDWEVELAVVIGKRGKYIKATDAMAHVAGFTVAHDVSARDWQMGRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVNGEVMQSSNTNQMVFKTEELITWVSQFVTLYPGDIILTGTPPGVGVFRKPPVFLKKGDEVQCEIEELGVIINKDVFPGVRGHSHPVGKESRYIHMITPEKQC", "length": 341, "header": "tr|A0AAA9S920-1|A0AAA9S920_BOVIN Isoform 1 of Fumarylacetoacetate hydrolase domain containing 2A OS=Bos taurus OX=9913 GN=FAHD2A PE=3 SV=1 CANONICAL=A0AAA9S920-1" }, "locus": { "chromosome": "11", "start_pos": 2164619, "end_pos": 2157106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128293.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128293.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078649.1" } ] } }, { "isoform_ac": "A0AAQ6J790-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920/entry#A0AAQ6J790-1", "sequence": { "sequence": "MELMLGSSGRRLLTTVLQAQRWPFQPSRNMRLVQFQAPHLAGPHLGLESGNGGGVIDLNAFEPTLPKTMVEFLEQGEATLSVVRRALATQLPVLPRSEVTFLAPVTRPDKVVCVGMNYADHCREQNVPVPKEPIIFSKFASAIVGPYDNIILPPESQEVDWEVELAVVIGKRGKYIKATDAMAHVAGFTVAHDVSARDWQMGRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVNGEVMQSSNTNQMVFKTEELITWVSQFVTLYPGDIILTGTPPGVGVFRKPPVFLKKGDEVQCEIEELGVIINKVV", "length": 317, "header": "tr|A0AAQ6J790-1|A0AAQ6J790_BOVIN Computationally mapped isoform of Fumarylacetoacetate hydrolase domain containing 2A OS=Bos taurus OX=9913 GN=FAHD2A PE=3 SV=1 CANONICAL=A0AAA9S920-1" }, "locus": { "chromosome": "11", "start_pos": 2164378, "end_pos": 2156933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015354.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015354.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015354.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015354.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S920", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S920", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" } ], "pmid": "" }, { "name": "oxaloacetate tautomerase activity", "id": "GO:0050163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050163", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S920", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "oxaloacetate metabolic process", "id": "GO:0006107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006107", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S920", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S920" }, { "id": "PF01557", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01557" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fumarylacetoacetase-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 107, "end_pos": 312, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S733-1", "uniprot_ac": "A0AAA9S733", "uniprot_id": "A0AAA9S733_BOVIN", "mass": { "chemical_mass": 55706.0, "monoisotopic_mass": 55706.0 }, "refseq": {}, "gene_names": [ { "name": "RORC", "type": "recommended", "evidence": [ { "id": "A0AAA9S733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ] } ], "protein_names": [ { "name": "RAR related orphan receptor C", "type": "synonym", "evidence": [ { "id": "A0AAA9S733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RORC", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733", "locus": { "chromosome": "3", "start_pos": 18977805, "end_pos": 18953039, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017405", "url": "https://www.ensembl.org/id/ENSBTAG00000017405" } ] } } ], "crossref": [ { "id": "A0AAA9S733", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S733", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017405", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017405", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06968", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06968", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527470", "url": "https://www.ncbi.nlm.nih.gov/gene/527470", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NVEHHEV", "url": "https://omabrowser.org/oma/group/NVEHHEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKH1", "url": "https://www.orthodb.org/?gene=A0A3Q1LKH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM20", "url": "https://www.orthodb.org/?gene=A0A3Q1MM20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45805", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45805", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45805:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45805:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM20", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM20-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S733-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQREQAAKTPPMGAQGADTLACTLGLPDGQLPLGSSPDLPEASACPPSLLRAPGCGPSYSNSLAKTGLNGASYHLEYSPERGKAEGRENFYGIGSQLAPDRGGLHSEDPRRPGLGEPGRGLDSYFTPSFRSTPEVPYASLTEIEHLVQNVCKSYRDTCQLRLEDLLRQRSNIFSREEVAGYQRKSMWEMWGRCAHRLTEAIQYVVEFAKRLPGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNDTVFFEGKYGGVELFRALGCSELISSIFDFSRSLSALRFSEDEIALYTALVLINANRPGLQEKRKVEQLQCNLELAFHHHLCKTHRQGILAKLPPKGKLRSLCSQHVEKLQTFQHLHPIVVQAAFPPLYKELFSTEIESPEGLSK", "length": 497, "header": "tr|A0AAA9S733-1|A0AAA9S733_BOVIN Isoform 1 of RAR related orphan receptor C OS=Bos taurus OX=9913 GN=RORC PE=3 SV=1 CANONICAL=A0AAA9S733-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733/entry#A0A3Q1LKH1-1", "sequence": { "sequence": "MSGRSASHSFPLPAVGPGAPSSSLFPPLGPAPCPPGQPGQQGRHQGSCPMDRAPQRHHRASQGKRPCSLTELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQREQAAKTPPMGAQGADTLACTLGLPDGQLPLGSSPDLPEASACPPSLLRAPGCGPSYSNSLAKTGLNGASYHLEYSPERGKAEGRENFYGIGSQLAPDRGGLHSEDPRRPGLGEPGRGLDSYFTPSFRSTPEVPYASLTEIEHLVQNVCKSYRDTCQLRLEDLLRQRSNIFSREEVAGYQRKSMWEMWGRCAHRLTEAIQYVVEFAKRLPGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNDTVFFEGKYGGVELFRALGCSELISSIFDFSRSLSALRFSEDEIALYTALVLINANRPGLQEKRKVEQLQCNLELAFHHHLCKTHRQGILAKLPPKGKLRSLCSQHVEKLQTFQHLHPIVVQAAFPPLYKELFSTEIESPEGLSK", "length": 575, "header": "tr|A0A3Q1LKH1-1|A0A3Q1LKH1_BOVIN Computationally mapped isoform of RAR related orphan receptor C OS=Bos taurus OX=9913 GN=RORC PE=3 SV=2 CANONICAL=A0AAA9S733-1" }, "locus": { "chromosome": "3", "start_pos": 18977215, "end_pos": 18953307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073179.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073179.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057152.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057152.2" } ] } }, { "isoform_ac": "A0A3Q1MM20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733/entry#A0A3Q1MM20-1", "sequence": { "sequence": "MQKGQCPSCHLFCLSSRPQTLFLPSLPVSPPDVGTLCQPLLSPACCRARCSLLLSLPSPGPCSLPSWAARAARTAPRELPHGQGPTETSPSLAGDGGSCPASKDDKELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQREQAAKTPPMGAQGADTLACTLGLPDGQLPLGSSPDLPEASACPPSLLRAPGCGPSYSNSLAKTGLNGASYHLEYSPERGKAEGRENFYGIGSQLAPDRGGLHSEDPRRPGLGEPGRGLDSYFTPSFRSTPEVPYASLTEIEHLVQNVCKSYRDTCQLRLEDLLRQRSNIFSREEVAGYQRKSMWEMWGRCAHRLTEAIQYVVEFAKRLPGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNDTVFFEGKYGGVELFRALGCSELISSIFDFSRSLSALRFSEDEIALYTALVLINANRPGLQEKRKVEQLQCNLELAFHHHLCKTHRQGILAKLPPKGKLRSLCSQHVEKLQTFQHLHPIVVQAAFPPLYKELFSTEIESPEGLSK", "length": 611, "header": "tr|A0A3Q1MM20-1|A0A3Q1MM20_BOVIN Computationally mapped isoform of RAR related orphan receptor C OS=Bos taurus OX=9913 GN=RORC PE=3 SV=1 CANONICAL=A0AAA9S733-1" }, "locus": { "chromosome": "3", "start_pos": 18977215, "end_pos": 18953213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072859.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072859.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070415.1" } ] } }, { "isoform_ac": "A0AAA9S733-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733/entry#A0AAA9S733-1", "sequence": { "sequence": "MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQREQAAKTPPMGAQGADTLACTLGLPDGQLPLGSSPDLPEASACPPSLLRAPGCGPSYSNSLAKTGLNGASYHLEYSPERGKAEGRENFYGIGSQLAPDRGGLHSEDPRRPGLGEPGRGLDSYFTPSFRSTPEVPYASLTEIEHLVQNVCKSYRDTCQLRLEDLLRQRSNIFSREEVAGYQRKSMWEMWGRCAHRLTEAIQYVVEFAKRLPGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNDTVFFEGKYGGVELFRALGCSELISSIFDFSRSLSALRFSEDEIALYTALVLINANRPGLQEKRKVEQLQCNLELAFHHHLCKTHRQGILAKLPPKGKLRSLCSQHVEKLQTFQHLHPIVVQAAFPPLYKELFSTEIESPEGLSK", "length": 497, "header": "tr|A0AAA9S733-1|A0AAA9S733_BOVIN Isoform 1 of RAR related orphan receptor C OS=Bos taurus OX=9913 GN=RORC PE=3 SV=1 CANONICAL=A0AAA9S733-1" }, "locus": { "chromosome": "3", "start_pos": 18977215, "end_pos": 18959097, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095499.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095499.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077975.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0Q7K3-1", "protein_name": "RAR related orphan receptor C", "gene_name": "RORC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQREQAAKSPPAGAQGADPLACPLGLPDGQLPLGSSPDLPEASACPPGLLRAPSCGPSYSNSLVKAGLNGASYHLEYSPERGKAEGRENFYGTGSQLAPDRCGLRFEDPRHPGLGEPGRGPDSYCSPSFRSTPEAPYASLTEIEHLVQNVCKSYRDTCQLRLEDLLRQRSNIFSREEVAGYQRKSMWEMWERCAHRLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNHTVFFEGKYGGMELFRALGCSELISSIFDFSRSLSALRFSEDEIALYTALVLINANRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQGILAKLPPKGKLRSLCSQHVEKLQTFQHLHPIVVQVAFPPLYKELFSTEIESSDGLSE", "length": 497 }, "evidence": [ { "id": "A0AAA9S733", "url": "https://omabrowser.org/oma/group/A0AAA9S733/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P31396-1", "protein_name": "Probable nuclear hormone receptor HR3", "gene_name": "Hr3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYTQRMFDMWSSVTSKLEAHANNLGQSNVQSPAGQNNSSGSIKAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSYSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELFSIDSQQDLT", "length": 487 }, "evidence": [ { "id": "A0AAA9S733", "url": "https://omabrowser.org/oma/group/A0AAA9S733/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P51449-1", "protein_name": "Nuclear receptor ROR-gamma", "gene_name": "RORC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK", "length": 518 }, "evidence": [ { "id": "A0AAA9S733", "url": "https://omabrowser.org/oma/group/A0AAA9S733/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P51450-1", "protein_name": "Nuclear receptor ROR-gamma", "gene_name": "Rorc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK", "length": 516 }, "evidence": [ { "id": "A0AAA9S733", "url": "https://omabrowser.org/oma/group/A0AAA9S733/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "oxysterol binding", "id": "GO:0008142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008142", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" }, { "name": "cellular response to sterol", "id": "GO:0036315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S733", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 248, "end_pos": 487, "start_aa": "Glu", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S733" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 82, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 352, "end_pos": 354 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA25-1", "uniprot_ac": "A0AAA9SA25", "uniprot_id": "A0AAA9SA25_BOVIN", "mass": { "chemical_mass": 37086.0, "monoisotopic_mass": 37086.0 }, "refseq": { "ac": "XP_005212562", "name": "sideroflexin-5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212562" }, "gene_names": [ { "name": "SFXN5", "type": "recommended", "evidence": [ { "id": "A0AAA9SA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ] }, { "name": "SFXN5", "type": "synonym", "evidence": [ { "id": "XP_005212562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212562" } ] } ], "protein_names": [ { "name": "Sidoreflexin", "type": "recommended", "evidence": [ { "id": "A0AAA9SA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#names_and_taxonomy" } ] }, { "name": "sideroflexin-5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212562" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SFXN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25", "locus": { "chromosome": "11", "start_pos": 11498287, "end_pos": 11371517, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057495", "url": "https://www.ensembl.org/id/ENSBTAG00000057495" } ] } } ], "crossref": [ { "id": "A0AAA9SA25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528468", "url": "https://www.ncbi.nlm.nih.gov/gene/528468", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MSZ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MSZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11153:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212562", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212562", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADTATTASAAAASAANASTDAPPFQLGKPRFQQTSFFGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLHPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL", "length": 340, "header": "tr|A0AAA9SA25-1|A0AAA9SA25_BOVIN Isoform 1 of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=2 CANONICAL=A0AAA9SA25-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MSZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#A0A3Q1MSZ0-1", "sequence": { "sequence": "MADTATTASAAAASAANASTDAPPFQLGKPRFQQTSFFGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLHPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEDAQQHALAASWSLRSTVGRGAGASSQPQIMCYKCTEGDRNKPVRA", "length": 360, "header": "tr|A0A3Q1MSZ0-1|A0A3Q1MSZ0_BOVIN Computationally mapped isoform of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=2 CANONICAL=A0AAA9SA25-1" }, "locus": { "chromosome": "11", "start_pos": 11495302, "end_pos": 11371661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082793.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082793.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073276.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073276.2" } ] } }, { "isoform_ac": "A0AAA9S8S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#A0AAA9S8S8-1", "sequence": { "sequence": "MADTATTASAAAASAANASTDAPPFQLGKPRFQQTSFFGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLHPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL", "length": 318, "header": "tr|A0AAA9S8S8-1|A0AAA9S8S8_BOVIN Computationally mapped isoform of Sideroflexin 5 OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=1 CANONICAL=A0AAA9SA25-1" }, "locus": { "chromosome": "11", "start_pos": 11495354, "end_pos": 11371661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082449.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082449.1" } ] } }, { "isoform_ac": "A0AAA9SA25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#A0AAA9SA25-1", "sequence": { "sequence": "MADTATTASAAAASAANASTDAPPFQLGKPRFQQTSFFGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLHPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL", "length": 340, "header": "tr|A0AAA9SA25-1|A0AAA9SA25_BOVIN Isoform 1 of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=2 CANONICAL=A0AAA9SA25-1" }, "locus": { "chromosome": "11", "start_pos": 11495354, "end_pos": 11371661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134006.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134006.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082165.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082165.2" } ] } }, { "isoform_ac": "A0AAA9SN57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#A0AAA9SN57-1", "sequence": { "sequence": "MADTATTASAAAASAANASTDAPPFQLGKPRFQQTSFFGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLHPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVGQLSCRRVPGCSSLCKALCAWQPSAWPCHWPSASSLRCQRSKQAS", "length": 253, "header": "tr|A0AAA9SN57-1|A0AAA9SN57_BOVIN Computationally mapped isoform of Sideroflexin 5 OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=1 CANONICAL=A0AAA9SA25-1" }, "locus": { "chromosome": "11", "start_pos": 11495295, "end_pos": 11371661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121884.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121884.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085322.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085322.1" } ] } }, { "isoform_ac": "A0AAA9SRA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#A0AAA9SRA0-1", "sequence": { "sequence": "MPRPMHRPSSWANPASSRHPSLVASGTSWTSSTLAHSLSLRDVSERLCNCWKTISMGPCTQGLPMSSSGAHRKSSRLFYTRTPMRRSSCLLECQVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL", "length": 315, "header": "tr|A0AAA9SRA0-1|A0AAA9SRA0_BOVIN Computationally mapped isoform of Sideroflexin 5 OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=1 CANONICAL=A0AAA9SA25-1" }, "locus": { "chromosome": "11", "start_pos": 11495354, "end_pos": 11371710, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087874.1" } ] } }, { "isoform_ac": "A0AAA9THA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25/entry#A0AAA9THA6-1", "sequence": { "sequence": "MADTATTASAAAASAANASTDAPPFQLGKPRFQQTSFFGRFRHFLDIIDPRTLFVTELWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL", "length": 314, "header": "tr|A0AAA9THA6-1|A0AAA9THA6_BOVIN Computationally mapped isoform of Sideroflexin 5 OS=Bos taurus OX=9913 GN=SFXN5 PE=3 SV=1 CANONICAL=A0AAA9SA25-1" }, "locus": { "chromosome": "11", "start_pos": 11495354, "end_pos": 11371661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124264.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124264.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097626.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" }, { "name": "citrate transport", "id": "GO:0015746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" }, { "name": "mitochondrial transmembrane transport", "id": "GO:1990542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "citrate transmembrane transporter activity", "id": "GO:0015137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015137", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" }, { "name": "monoatomic ion transmembrane transporter activity", "id": "GO:0015075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015075", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 140, "end_pos": 142 }, { "start_pos": 153, "end_pos": 155 }, { "start_pos": 17, "end_pos": 19 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6E6-1", "uniprot_ac": "A0AAA9S6E6", "uniprot_id": "A0AAA9S6E6_BOVIN", "mass": { "chemical_mass": 11647.0, "monoisotopic_mass": 11647.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Pleckstrin homology domain containing A5", "type": "synonym", "evidence": [ { "id": "A0AAA9S6E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6", "locus": {} } ], "crossref": [ { "id": "A0AAA9S6E6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6E6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9S6E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAADLNLEWICSLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINSEHHLSVPCQNTSSLITVVMKNGRNS", "length": 103, "header": "tr|A0AAA9S6E6-1|A0AAA9S6E6_BOVIN Isoform 1 of Pleckstrin homology domain containing A5 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6E6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6/entry#A0AAA9S6E6-1", "sequence": { "sequence": "MAADLNLEWICSLPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINSEHHLSVPCQNTSSLITVVMKNGRNS", "length": 103, "header": "tr|A0AAA9S6E6-1|A0AAA9S6E6_BOVIN Isoform 1 of Pleckstrin homology domain containing A5 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9S6E6-1" }, "locus": { "chromosome": "5", "start_pos": 90862727, "end_pos": 90782906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081558.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081558.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6E6" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 44, "start_aa": "Cys", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S5S5-1", "uniprot_ac": "A0AAA9S5S5", "uniprot_id": "A0AAA9S5S5_BOVIN", "mass": { "chemical_mass": 35968.0, "monoisotopic_mass": 35968.0 }, "refseq": { "ac": "XP_024842610", "name": "V-set and transmembrane domain-containing protein 4 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842610" }, "gene_names": [ { "name": "VSTM4", "type": "recommended", "evidence": [ { "id": "A0AAA9S5S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5" } ] }, { "name": "VSTM4", "type": "synonym", "evidence": [ { "id": "XP_024842610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842610" } ] } ], "protein_names": [ { "name": "V-set and transmembrane domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9S5S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5/entry#names_and_taxonomy" } ] }, { "name": "V-set and transmembrane domain-containing protein 4 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024842610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842610" } ] } ], "function": [ { "annotation": "Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5#function" }, { "database": "UniProtKB", "id": "ARBA00059484", "url": "https://www.uniprot.org/uniprotkb/ARBA00059484#function" }, { "database": "UniProtKB", "id": "F1N6Z3", "url": "https://www.uniprot.org/uniprotkb/F1N6Z3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VSTM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5", "locus": { "chromosome": "28", "start_pos": 43287483, "end_pos": 43376898, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006288", "url": "https://www.ensembl.org/id/ENSBTAG00000006288" } ] } } ], "crossref": [ { "id": "A0AAA9S5S5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S5S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006288", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006288", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100336454", "url": "https://www.ncbi.nlm.nih.gov/gene/100336454", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336454", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336454", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDFCLAI", "url": "https://omabrowser.org/oma/group/GDFCLAI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12207:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12207:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842610", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842610", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Z3", "url": "https://www.uniprot.org/uniprotkb/F1N6Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Z3-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLALAVAVLLARAPAPEVCGALNVTVSPGPVVDYLEGENATLLCHVSQKRRKDSLLAVRWFFARPDSQEALMVKMTKLRIVQYYGNFSRSAYRQRLRLLEERRGALYTLSVLTLQPTDQGHYVCKVQEISKHRNKWTAWSNGSSGTEMRVISLKSSEDSSVEKKKETWAFFEDLYVYAVLVCCVGILSVLLFTLTIIWQSVFSKRKSRVRHYLVKCPQNSSGETVTSVTSLAPLQPKKGKRRKEKADVPPAVPAKAPIATTFHKPKLLKPQRKVTLPKIAEENLTYAELELIKPHRAAKGIPTSTVYAQILFEENKL", "length": 319, "header": "tr|A0AAA9S5S5-1|A0AAA9S5S5_BOVIN Isoform 1 of V-set and transmembrane domain-containing protein 4 OS=Bos taurus OX=9913 GN=VSTM4 PE=4 SV=1 CANONICAL=A0AAA9S5S5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5/entry#A0AAA9S5S5-1", "sequence": { "sequence": "MRLLALAVAVLLARAPAPEVCGALNVTVSPGPVVDYLEGENATLLCHVSQKRRKDSLLAVRWFFARPDSQEALMVKMTKLRIVQYYGNFSRSAYRQRLRLLEERRGALYTLSVLTLQPTDQGHYVCKVQEISKHRNKWTAWSNGSSGTEMRVISLKSSEDSSVEKKKETWAFFEDLYVYAVLVCCVGILSVLLFTLTIIWQSVFSKRKSRVRHYLVKCPQNSSGETVTSVTSLAPLQPKKGKRRKEKADVPPAVPAKAPIATTFHKPKLLKPQRKVTLPKIAEENLTYAELELIKPHRAAKGIPTSTVYAQILFEENKL", "length": 319, "header": "tr|A0AAA9S5S5-1|A0AAA9S5S5_BOVIN Isoform 1 of V-set and transmembrane domain-containing protein 4 OS=Bos taurus OX=9913 GN=VSTM4 PE=4 SV=1 CANONICAL=A0AAA9S5S5-1" }, "locus": { "chromosome": "28", "start_pos": 43376825, "end_pos": 43288487, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128355.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128355.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080563.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080563.1" } ] } }, { "isoform_ac": "F1N6Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5/entry#F1N6Z3-1", "sequence": { "sequence": "MRLLALAVAVLLARAPAPEVCGALNVTVSPGPVVDYLEGENATLLCHVSQKRRKDSLLAVRWFFARPDSQEALMVKMTKLRIVQYYGNFSRSAYRQRLRLLEERRGALYTLSVLTLQPTDQGHYVCKVQEISKHRNKWTAWSNGSSGTEMRVISLKSSEDSSVEKKKETWAFFEDLYVYAVLVCCVGILSVLLFTLTIIWQSVFSKRKSRVRHYLVKCPQNSSGETVTSVTSLAPLQPKKGKRRKEKADVPPAVPAKAPIATTFHKPKLLKPQRKVTLIVKVHRRLRSQLPAGCGSAAGSQPQLRRMLLRVMLPQPEIPMCH", "length": 322, "header": "tr|F1N6Z3-1|F1N6Z3_BOVIN Computationally mapped isoform of V-set and transmembrane domain-containing protein 4 OS=Bos taurus OX=9913 GN=VSTM4 PE=4 SV=4 CANONICAL=A0AAA9S5S5-1" }, "locus": { "chromosome": "28", "start_pos": 43376825, "end_pos": 43297942, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008254.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008254.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008254.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008254.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336454", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336454", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480KSS8-1", "protein_name": "V-set and transmembrane domain-containing protein 4", "gene_name": "VSTM4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLLALTAAVLLARAPAPEVCGALNVTVSPGPVVDYLEGENATLLCHVSQKRRKDSLLAVRWFFARPDAQEVLMVKMTKLRMVQYYGNFSRSAYRQRLRLLEQRRGTLYTLSVLTLRPADQGHYVCKVQEISKHRNKWTAWSNGSSATEMRVISLKASEDSSFEKKKETWAFFEDLYVYAVLVCCVGILSVLLFTLTIIWQSLFSKRKSRVRHYLVKCPQNSSGETVTSVTSLAPLQPKKGKRRKEKADVPPAVPAKAPIAATFHKPKLLKPQRKVALPKIAEENLTYAELELIKPNQAAKGVPTSTVYAQILFEENKL", "length": 319 }, "evidence": [ { "id": "A0AAA9S5S5", "url": "https://omabrowser.org/oma/group/A0AAA9S5S5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1C946-1", "protein_name": "V-set and transmembrane domain-containing protein 4", "gene_name": "VSTM4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLLATALAALLASAPAPDVCKALNVTVSPGPTVRYSEGDNATLYCHISQKRKTDNLLAVRWVFAVSPTQEYLMIKMTKFGSVQYYGNYTHHFHKQRLRLHKEKHGTMYKFLILSLQQTDQGHYICKVQEIGKHRNKWTAWSNGTAATEIRVISSKASDDPTYKKKHEAWKFFEDLYVYAVFVCSIGIISVLLFTLVILCQSLLNKRRCTVKHYLVKCPQNSSGETVTSVTSMSPLQPKKLKKRKEKAELPPAIPEKAPIANIPKPKLLKPQRKLMLPKIAEENLTYAELELMKPIQEAKGIPSTTVYAQILFEENKM", "length": 318 }, "evidence": [ { "id": "A0AAA9S5S5", "url": "https://omabrowser.org/oma/group/A0AAA9S5S5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8IW00-1", "protein_name": "V-set and transmembrane domain-containing protein 4", "gene_name": "VSTM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLLALAAAALLARAPAPEVCAALNVTVSPGPVVDYLEGENATLLCHVSQKRRKDSLLAVRWFFAHSFDSQEALMVKMTKLRVVQYYGNFSRSAKRRRLRLLEEQRGALYRLSVLTLQPSDQGHYVCRVQEISRHRNKWTAWSNGSSATEMRVISLKASEESSFEKTKETWAFFEDLYVYAVLVCCVGILSILLFMLVIVWQSVFNKRKSRVRHYLVKCPQNSSGETVTSVTSLAPLQPKKGKRQKEKPDIPPAVPAKAPIAPTFHKPKLLKPQRKVTLPKIAEENLTYAELELIKPHRAAKGAPTSTVYAQILFEENKL", "length": 320 }, "evidence": [ { "id": "A0AAA9S5S5", "url": "https://omabrowser.org/oma/group/A0AAA9S5S5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S5S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5S5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 154, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 221, "end_pos": 223 }, { "start_pos": 25, "end_pos": 27 }, { "start_pos": 285, "end_pos": 287 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7L4-1", "uniprot_ac": "A0AAA9S7L4", "uniprot_id": "A0AAA9S7L4_BOVIN", "mass": { "chemical_mass": 23252.0, "monoisotopic_mass": 23252.0 }, "refseq": { "ac": "XP_002690485", "name": "zinc finger BED domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690485" }, "gene_names": [ { "name": "ZBED3", "type": "recommended", "evidence": [ { "id": "A0AAA9S7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ] }, { "name": "ZBED3", "type": "synonym", "evidence": [ { "id": "XP_002690485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690485" } ] } ], "protein_names": [ { "name": "Zinc finger BED-type containing 3", "type": "synonym", "evidence": [ { "id": "A0AAA9S7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4/entry#names_and_taxonomy" } ] }, { "name": "zinc finger BED domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "XP_002690485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690485" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBED3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4", "locus": { "chromosome": "10", "start_pos": 8228202, "end_pos": 8253305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065804", "url": "https://www.ensembl.org/id/ENSBTAG00000065804" } ] } } ], "crossref": [ { "id": "ENSBTAG00000052845", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052845", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615651", "url": "https://www.ncbi.nlm.nih.gov/gene/615651", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615651", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615651", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDSCVIT", "url": "https://omabrowser.org/oma/group/RDSCVIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV58", "url": "https://www.orthodb.org/?gene=A0A3Q1LV58", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35827:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35827:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02892", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02892", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV58-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSEEPAVTMDETGGPDAAAGRLGAPYSEAWGYFHLAPARPGHAAGPWATCRLCGEQVGRGPGWHASTPALWKHLRSAHRRELAESAARRSPPAAPGPVAAAEGDWARLLEQMGALAVRGSLRERELARREAAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARQREVSRREGALAPAPAPSLHAPLKDEPEGEPRDGCVITKVLL", "length": 214, "header": "tr|A0AAA9S7L4-1|A0AAA9S7L4_BOVIN Isoform 1 of Zinc finger BED-type containing 3 OS=Bos taurus OX=9913 GN=ZBED3 PE=4 SV=1 CANONICAL=A0AAA9S7L4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4/entry#A0A3Q1LV58-1", "sequence": { "sequence": "MRSEEPAVTMDETGGPDAAAGRLGAPYSEAWGYFHLAPARPGHAAGPWATCRLCGEQVGRGPGWHASTPALWKHLRSAHRRELAESAARRSPPAAPGPVAAAEGDWARLLEQMGALAVRGSLRERELARREAAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARQREVSRREGALAPAPAPSLHAPLKDEPEGEPRDGCVITKVLLPNYVLLLGSSTWRAATVTFVPKTDYLQPCVLFPANETERGLKWLVQDDSSPIQSLPPDAVFPAAVPLPLLLTHPS", "length": 289, "header": "tr|A0A3Q1LV58-1|A0A3Q1LV58_BOVIN Computationally mapped isoform of Zinc finger BED-type containing 3 OS=Bos taurus OX=9913 GN=ZBED3 PE=4 SV=2 CANONICAL=A0AAA9S7L4-1" }, "locus": { "chromosome": "10", "start_pos": 8235638, "end_pos": 8233440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078442.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078442.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061078.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061078.2" } ] } }, { "isoform_ac": "A0AAA9S7L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4/entry#A0AAA9S7L4-1", "sequence": { "sequence": "MRSEEPAVTMDETGGPDAAAGRLGAPYSEAWGYFHLAPARPGHAAGPWATCRLCGEQVGRGPGWHASTPALWKHLRSAHRRELAESAARRSPPAAPGPVAAAEGDWARLLEQMGALAVRGSLRERELARREAAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARQREVSRREGALAPAPAPSLHAPLKDEPEGEPRDGCVITKVLL", "length": 214, "header": "tr|A0AAA9S7L4-1|A0AAA9S7L4_BOVIN Isoform 1 of Zinc finger BED-type containing 3 OS=Bos taurus OX=9913 GN=ZBED3 PE=4 SV=1 CANONICAL=A0AAA9S7L4-1" }, "locus": { "chromosome": "10", "start_pos": 8229130, "end_pos": 8228489, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125205.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125205.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101066.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101066.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615651", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615651", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4V7E3-1", "protein_name": "Zinc finger, BED-type containing 3", "gene_name": "Zbed3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSEEPRKTMEDSRRPDDPAEQGGPCPAPAGPSYSEAWGYFHLDPAQPRHRMMSAWATCRLCGEQVGGLPSFQMWTRALWRHLSDTHLRELKKSAAPSVKPATSCPPQHSSTVAAEGDWALLLEQMGALAVRGSLREVELERRETALKQAELELERRHQALQQEALCLEQARSQLQAEREAFSAWMKKQSPNANSNAQVPALPSSPPLPSSPPLLPKEDPDIHDDDNDVITKVVQ", "length": 235 }, "evidence": [ { "id": "A0AAA9S7L4", "url": "https://omabrowser.org/oma/group/A0AAA9S7L4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96IU2-1", "protein_name": "Zinc finger BED domain-containing protein 3", "gene_name": "ZBED3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSGEPACTMDQARGLDDAAARGGQCPGLGPAPTPTPPGRLGAPYSEAWGYFHLAPGRPGHPSGHWATCRLCGEQVGRGPGFHAGTSALWRHLRSAHRRELESSGAGSSPPAAPCPPPPGPAAAPEGDWARLLEQMGALAVRGSRRERELERRELAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARLRDVSRREGALGWAPAAPPPLKDDPEGDRDGCVITKVLL", "length": 234 }, "evidence": [ { "id": "A0AAA9S7L4", "url": "https://omabrowser.org/oma/group/A0AAA9S7L4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D0L1-1", "protein_name": "Zinc finger BED domain-containing protein 3", "gene_name": "Zbed3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKSKKPLKITMEDSRRLNDPAEQGGLCPAPVGPSYSEAWGYFHLDPAQPRHRMMSAWATCRLCGLQVGGLPNFQMWTRALCQHLSDVHLPELKKSAAPSSPTTMPCPPPPSPTMAAEGDWARLLEQMGELAMRGSQRELELERREAALMQAELELERKRQALKQEAQSVEQERHQLQVEREALSKWIKKQSPGAQVPEPPSPLPLLPKEDPDIHDNNSDNDMVTKVLL", "length": 228 }, "evidence": [ { "id": "A0AAA9S7L4", "url": "https://omabrowser.org/oma/group/A0AAA9S7L4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" }, { "name": "response to glucose", "id": "GO:0009749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009749", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S7L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7L4" }, { "id": "PS50808", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50808" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BED-type", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 86, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S8G0-1", "uniprot_ac": "A0AAA9S8G0", "uniprot_id": "A0AAA9S8G0_BOVIN", "mass": { "chemical_mass": 183607.0, "monoisotopic_mass": 183607.0 }, "refseq": { "ac": "NP_001193672", "name": "thrombospondin type-1 domain-containing protein 7A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193672" }, "gene_names": [ { "name": "THSD7A", "type": "recommended", "evidence": [ { "id": "A0AAA9S8G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ] }, { "name": "THSD7A", "type": "synonym", "evidence": [ { "id": "NP_001193672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193672" } ] } ], "protein_names": [ { "name": "Thrombospondin type-1 domain-containing protein 7A", "type": "recommended", "evidence": [ { "id": "A0AAA9S8G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0/entry#names_and_taxonomy" } ] }, { "name": "thrombospondin type-1 domain-containing protein 7A precursor", "type": "synonym", "evidence": [ { "id": "NP_001193672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193672" } ] }, { "name": "thrombospondin, type I, domain containing 7A", "type": "synonym", "evidence": [ { "id": "NP_001193672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193672" } ] } ], "function": [ { "annotation": "Plays a role in actin cytoskeleton rearrangement.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0#function" }, { "database": "UniProtKB", "id": "ARBA00055483", "url": "https://www.uniprot.org/uniprotkb/ARBA00055483#function" }, { "database": "UniProtKB", "id": "F1MLQ7", "url": "https://www.uniprot.org/uniprotkb/F1MLQ7#function" }, { "database": "UniProtKB", "id": "G3MZL9", "url": "https://www.uniprot.org/uniprotkb/G3MZL9#function" } ] }, { "annotation": "The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0#function" }, { "database": "UniProtKB", "id": "ARBA00056892", "url": "https://www.uniprot.org/uniprotkb/ARBA00056892#function" }, { "database": "UniProtKB", "id": "F1MLQ7", "url": "https://www.uniprot.org/uniprotkb/F1MLQ7#function" }, { "database": "UniProtKB", "id": "G3MZL9", "url": "https://www.uniprot.org/uniprotkb/G3MZL9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THSD7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0", "locus": { "chromosome": "4", "start_pos": 19514167, "end_pos": 19990087, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007680", "url": "https://www.ensembl.org/id/ENSBTAG00000007680" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007680", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007680", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782187", "url": "https://www.ncbi.nlm.nih.gov/gene/782187", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782187", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782187", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MLQ7", "url": "https://www.orthodb.org/?gene=F1MLQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZL9", "url": "https://www.orthodb.org/?gene=G3MZL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11311:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11311:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23308", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23308", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193672", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLQ7", "url": "https://www.uniprot.org/uniprotkb/F1MLQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLQ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZL9", "url": "https://www.uniprot.org/uniprotkb/G3MZL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZL9-1", "url": "https://www.uniprot.org/uniprotkb/G3MZL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPAGRSASRSRGTAGRHPAVLPLLLLLLLCPGAYGAAAPGEAEAPILYLWKTGPWGRCMGDGCGPGGIQTRAVWCAHVEGWTTLHTNCKPAERPSNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECVKGEEGIQVREITCIEKEKDVPAEDIICEYFEPKPLLEQACLIPCRQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSGPCEAEERMYSLQVGPWSTCSMPHSRQVRQARRRGKSKERDKDRGKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCTNKTGKAADLSFCQQEKLPMTFQACVMTKECQVSEWSEWSPCSKTCHDPASPKGTRMRARLIRQFPIGSEKKCPELEEEEPCVSQGDGVAPCATYSWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGVQTREAYCVQANENLLSLNTHKDKEAPKPVDLKSCTGPVPNTTQLCHIPCPIECEVSPWTAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGGTGNCPHLLEAIPCEEPSCYDWKAVRLGDCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDVPCPRDCVLSMWSAWSSCSHTCSGKTTEGKQTRARSILAYAGEEGGVQCPNTSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTAWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCRKDCIVTPYSDWTSCPSSCKEGDSGIKKQTRHRVIIQPPANGGRDCADPLYEEKACEAPQVCQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLRYAGPVPALTQACQMPCQDDCQLTSWSRFSSCNGDCGAVRTRKRAIVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKAEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCSQYIWVTEPWSICKVTFVNTRDNCGEGVQTRKVRCMQNTADGPSDHVEDYLCDPEEMPLGSRECKLPCPEDCVVSEWGPWTRCSLPCNQSTFRQRAADPIRQPAEEGRACPDTVEKEPCNLNKNCFHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVNLKYCEELGLEKTWQMNMSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPALMEQSKPCPVKPCYQWRYGPWSACQVQDAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCTDIEPAIDGNKKAVLEETCTQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRAVIIQELENQHLCPEQKLETKPCDDGQCYEYKWMASAWKGSSRTVWCQRSDGVNVTGGCLVVRQPDADRSCNPPCSQPHSYCSETRTCSCEEGYTEVMSSNGTLEQCTLIPVMLIPTVEDKRGDVKTSRAVHPTQPSSNPVGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM", "length": 1647, "header": "tr|A0AAA9S8G0-1|A0AAA9S8G0_BOVIN Isoform 1 of Thrombospondin type-1 domain-containing protein 7A OS=Bos taurus OX=9913 GN=THSD7A PE=4 SV=1 CANONICAL=A0AAA9S8G0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0/entry#A0AAA9S8G0-1", "sequence": { "sequence": "MGLPAGRSASRSRGTAGRHPAVLPLLLLLLLCPGAYGAAAPGEAEAPILYLWKTGPWGRCMGDGCGPGGIQTRAVWCAHVEGWTTLHTNCKPAERPSNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECVKGEEGIQVREITCIEKEKDVPAEDIICEYFEPKPLLEQACLIPCRQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSGPCEAEERMYSLQVGPWSTCSMPHSRQVRQARRRGKSKERDKDRGKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCTNKTGKAADLSFCQQEKLPMTFQACVMTKECQVSEWSEWSPCSKTCHDPASPKGTRMRARLIRQFPIGSEKKCPELEEEEPCVSQGDGVAPCATYSWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGVQTREAYCVQANENLLSLNTHKDKEAPKPVDLKSCTGPVPNTTQLCHIPCPIECEVSPWTAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGGTGNCPHLLEAIPCEEPSCYDWKAVRLGDCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDVPCPRDCVLSMWSAWSSCSHTCSGKTTEGKQTRARSILAYAGEEGGVQCPNTSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTAWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCRKDCIVTPYSDWTSCPSSCKEGDSGIKKQTRHRVIIQPPANGGRDCADPLYEEKACEAPQVCQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLRYAGPVPALTQACQMPCQDDCQLTSWSRFSSCNGDCGAVRTRKRAIVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKAEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCSQYIWVTEPWSICKVTFVNTRDNCGEGVQTRKVRCMQNTADGPSDHVEDYLCDPEEMPLGSRECKLPCPEDCVVSEWGPWTRCSLPCNQSTFRQRAADPIRQPAEEGRACPDTVEKEPCNLNKNCFHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVNLKYCEELGLEKTWQMNMSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPALMEQSKPCPVKPCYQWRYGPWSACQVQDAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCTDIEPAIDGNKKAVLEETCTQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRAVIIQELENQHLCPEQKLETKPCDDGQCYEYKWMASAWKGSSRTVWCQRSDGVNVTGGCLVVRQPDADRSCNPPCSQPHSYCSETRTCSCEEGYTEVMSSNGTLEQCTLIPVMLIPTVEDKRGDVKTSRAVHPTQPSSNPVGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM", "length": 1647, "header": "tr|A0AAA9S8G0-1|A0AAA9S8G0_BOVIN Isoform 1 of Thrombospondin type-1 domain-containing protein 7A OS=Bos taurus OX=9913 GN=THSD7A PE=4 SV=1 CANONICAL=A0AAA9S8G0-1" }, "locus": { "chromosome": "4", "start_pos": 19989888, "end_pos": 19519084, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078441.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078441.1" } ] } }, { "isoform_ac": "F1MLQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0/entry#F1MLQ7-1", "sequence": { "sequence": "MGLPAGRSASRSRGTAGRHPAVLPLLLLLLLCPGAYGAAAPGEAEAPILYLWKTGPWGRCMGDGCGPGGIQTRAVWCAHVEGWTTLHTNCKPAERPSNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECVKGEEGIQVREITCIEKEKDVPAEDIICEYFEPKPLLEQACLIPCRQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSGPCEAEERMYSLQVGPWSTCSMPHSRQVRQARRRGKSKERDKDRGKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCTNKTGKAADLSFCQQEKLPMTFQACVMTKECQVSEWSEWSPCSKTCHDPASPKGTRMRARLIRQFPIGSEKKCPELEEEEPCVSQGDGVAPCATYSWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGVQTREAYCVQANENLLSLNTHKDKEAPKPVDLKSCTGPVPNTTQLCHIPCPIECEVSPWTAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGGTGNCPHLLEAIPCEEPSCYDWKAVRLGDCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDVPCPRDCVLSMWSAWSSCSHTCSGKTTEGKQTRARSILAYAGEEGGVQCPNTSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTAWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCRKDCIVTPYSDWTSCPSSCKEGDSGIKKQTRHRVIIQPPANGGRDCADPLYEEKACEAPQVCQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLRYAGPVPALTQACQMPCQDDCQLTSWSRFSSCNGDCGAVRTRKRAIVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKAEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCSQYIWVTEPWSICKVTFVNTRDNCGEGVQTRKVRCMQNTADGPSDHVEDYLCDPEEMPLGSRECKLPCPEDCVVSEWGPWTRCSLPCNQSTFRQRAADPIRQPAEEGRACPDTVEKEPCNLNKNCFHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVNLKYCEELGLEKTWQMNMSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPALMEQSKPCPVKPCYQWRYGPWSACQVQDAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCTDIEPAIDGNKKAVLEETCTQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRAVIIQELENQHLCPEQKLETKPCDDGQCYEYKWMASAWKGSSRTVWCQRSDGVNVTGGCLVVRQPDADRSCNPPCSQPHSYCSETRTCSCEEGYTEVMSSNGTLEQCTLIPVMLIPTVEDKRGDVKTSRAVHPTQPSSNPVGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADILRVLKEEQSVNTSVRNQVRQPSSLGLVAM", "length": 1676, "header": "tr|F1MLQ7-1|F1MLQ7_BOVIN Computationally mapped isoform of Thrombospondin type-1 domain-containing protein 7A OS=Bos taurus OX=9913 GN=THSD7A PE=4 SV=3 CANONICAL=A0AAA9S8G0-1" }, "locus": { "chromosome": "4", "start_pos": 19989888, "end_pos": 19514724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010106.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010106.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010106.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010106.7" } ] } }, { "isoform_ac": "G3MZL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0/entry#G3MZL9-1", "sequence": { "sequence": "MGLPAGRSASRSRGTAGRHPAVLPLLLLLLLCPGAYGAAAPGEAEAPILYLWKTGPWGRCMGDGCGPGGIQTRAVWCAHVEGWTTLHTNCKPAERPSNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECVKGEEGIQVREITCIEKEKDVPAEDIICEYFEPKPLLEQACLIPCRQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSGPCEAEERMYSLQVGPWSTCSMPHSRQVRQARRRGKSKERDKDRGKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCTNKTGKAADLSFCQQEKLPMTFQACVMTKECQVSEWSEWSPCSKTCHDPASPKGTRMRARLIRQFPIGSEKKCPELEEEEPCVSQGDGVAPCATYSWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGVQTREAYCVQANENLLSLNTHKDKEAPKPVDLKSCTGPVPNTTQLCHIPCPIECEVSPWTAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGGTGNCPHLLEAIPCEEPSCYDWKAVRLGDCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDVPCPRDCVLSMWSAWSSCSHTCSGKTTEGKQTRARSILAYAGEEGGVQCPNTSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTAWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCRKDCIVTPYSDWTSCPSSCKEGDSGIKKQTRHRVIIQPPANGGRDCADPLYEEKACEAPQVCQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLRYAGPVPALTQACQMPCQDDCQLTSWSRFSSCNGDCGAVRTRKRAIVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKAEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQVYEVVPCHSDCSQYIWVTEPWSICKVTFVNTRDNCGEGVQTRKVRCMQNTADGPSDHVEDYLCDPEEMPLGSRECKLPCPEDCVVSEWGPWTRCSLPCNQSTFRQRAADPIRQPAEEGRACPDTVEKEPCNLNKNCFHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVNLKYCEELGLEKTWQMNMSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPALMEQSKPCPVKPCYQWRYGPWSACQVQDAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCTDIEPAIDGNKKAVLEETCTQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRAVIIQELENQHLCPEQKLETKPCDDGQCYEYKWMASAWKGSSRTVWCQRSDGVNVTGGCLVVRQPDADRSCNPPCSQPHSYCSEMGD", "length": 1521, "header": "tr|G3MZL9-1|G3MZL9_BOVIN Computationally mapped isoform of Thrombospondin type-1 domain-containing protein 7A OS=Bos taurus OX=9913 GN=THSD7A PE=4 SV=3 CANONICAL=A0AAA9S8G0-1" }, "locus": { "chromosome": "4", "start_pos": 19989888, "end_pos": 19519935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065400.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065400.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055019.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055019.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782187", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782187", "resource": "KEGG Pathway" }, { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S8G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1033, "end_pos": 1035, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1172, "end_pos": 1174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1215, "end_pos": 1217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1266, "end_pos": 1268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1356, "end_pos": 1358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1490, "end_pos": 1492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1537, "end_pos": 1539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 669, "end_pos": 671, "annotation": "n_glycosylation_sequon" }, { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 958, "end_pos": 960, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S8G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" }, { "id": "PF19028", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spondin-like TSP1", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 237, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S8G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G0" }, { "id": "PF23308", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23308" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thrombospondin type-1", "eco_id": "ECO_0000259", "start_pos": 1509, "end_pos": 1548, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1033, "end_pos": 1035 }, { "start_pos": 1172, "end_pos": 1174 }, { "start_pos": 1215, "end_pos": 1217 }, { "start_pos": 1266, "end_pos": 1268 }, { "start_pos": 1356, "end_pos": 1358 }, { "start_pos": 1490, "end_pos": 1492 }, { "start_pos": 1537, "end_pos": 1539 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 441, "end_pos": 443 }, { "start_pos": 490, "end_pos": 492 }, { "start_pos": 669, "end_pos": 671 }, { "start_pos": 707, "end_pos": 709 }, { "start_pos": 958, "end_pos": 960 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9A9-1", "uniprot_ac": "A0AAA9S9A9", "uniprot_id": "A0AAA9S9A9_BOVIN", "mass": { "chemical_mass": 73813.0, "monoisotopic_mass": 73813.0 }, "refseq": {}, "gene_names": [ { "name": "NEK11", "type": "recommended", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase Nek11", "type": "recommended", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#names_and_taxonomy" } ] }, { "name": "Never in mitosis A-related kinase 11", "type": "synonym", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MHW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHW8#function" }, { "database": "UniProtKB", "id": "ARBA00055453", "url": "https://www.uniprot.org/uniprotkb/ARBA00055453#function" }, { "database": "UniProtKB", "id": "E1BJU4", "url": "https://www.uniprot.org/uniprotkb/E1BJU4#function" }, { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9#function" }, { "database": "UniProtKB", "id": "A0A3Q1LUV8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUV8#function" }, { "database": "UniProtKB", "id": "A0A3Q1M9F6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEK11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9", "locus": { "chromosome": "1", "start_pos": 138565105, "end_pos": 138838351, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009258", "url": "https://www.ensembl.org/id/ENSBTAG00000009258" } ] } } ], "crossref": [ { "id": "A0AAA9S9A9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S9A9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009258", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009258", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614924", "url": "https://www.ncbi.nlm.nih.gov/gene/614924", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUV8", "url": "https://www.orthodb.org/?gene=A0A3Q1LUV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9F6", "url": "https://www.orthodb.org/?gene=A0A3Q1M9F6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHW8", "url": "https://www.orthodb.org/?gene=A0A3Q1MHW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BJU4", "url": "https://www.orthodb.org/?gene=E1BJU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44899", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44899", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44899:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44899:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-69601", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LUV8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUV8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9F6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9F6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHW8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJU4", "url": "https://www.uniprot.org/uniprotkb/E1BJU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJU4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKFREAAKCVSGSIAVSTCPKSLIARRYMLQQKLGSGSFGTVFLVSDKKAKQGEELKVLKEICIGELNPNETVQATLEAQLLSKLNHPAIVKFHANFVEQDKFCIITEYCEGRDLDCKIQEYKEAGKTFPESQIIEWFIQLLLGVDYMHERKILHRDLKSKNIFLKNNKLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFTGSNFLSIVLKIVEGDTPSLPERYPRQLNAIMESMLNKSPSLRPSAIEILKLPYIDEQLQDLMCRYSEMALEDKNLNSQEEATYIINAVQKKIHLQTLRALSEVQKMTPRERMRVRKVQAADEEARKLKRLVEEKYEENNKRMRELRSRNFQRQTVDVLHKKIEHLMGMEEKERQPERRSCPLEEDGERRPGRVEECDDPASDNLPESQPIPSLDLCTLGSNVEDTIADLGDHEIPEDPLVAEEYYADVFDSCSEESEESEEGKTVFSVKDEEVEDEGPQPVYRTNQQDSDTEALARCLEHVLGCTTLDTRTVTSSAPDTPSEPTIFNSAMARTRMKHMRESAVQKLGAEVFEEVYSYLKRARQQGASEAEVWAALETVVPRASDCFEVDQLLYFEEQLLITRAEGVTLPQNHHE", "length": 647, "header": "tr|A0AAA9S9A9-1|A0AAA9S9A9_BOVIN Isoform 1 of Serine/threonine-protein kinase Nek11 OS=Bos taurus OX=9913 GN=NEK11 PE=3 SV=2 CANONICAL=A0AAA9S9A9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#A0A3Q1LUV8-1", "sequence": { "sequence": "MLKFREAAKCVSGSIAVSTCPKSLIARRYMLQQKLGSGSFGTVFLVSDKKAKQGEELKVLKEICIGELNPNETVQATLEAQLLSKLNHPAIVKFHANFVEQDKFCIITEYCEGRDLDCKIQEYKEAGKTFPESQIIEWFIQLLLGVDYMHERKILHRDLKSKNIFLKNNKLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWQKKIHLQTLRALSEVQKMTPRERMRVRKVQAADEEARKLKRLVEEKYEENNKRMRELRSRNFQRQTVDVLHKKIEHLMGMEEKERQPERRSCPLEEDGERRPGRVEECDDPASDNLPESQPIPSLDLCTLGSNVEDTIADLGDHEIPEDPLVAEEYYADVFDSCSEESEESEEGKTVFSVKDEEVEDEGPQPVYRTNQQDSDTEALARCLEHVLGCTTLDTRTVTSSAPDTPSEPTIFNSAMARTRMKHMRESAVQKLGAEVFEEVYSYLKRARQQGASEAEVWAALETVVPRASDCFEVDQLLYFEEQLLITRAEGVTLPQNHHE", "length": 542, "header": "tr|A0A3Q1LUV8-1|A0A3Q1LUV8_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek11 OS=Bos taurus OX=9913 GN=NEK11 PE=3 SV=2 CANONICAL=A0AAA9S9A9-1" }, "locus": { "chromosome": "1", "start_pos": 138835180, "end_pos": 138565422, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076529.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076529.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060959.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060959.2" } ] } }, { "isoform_ac": "A0A3Q1M9F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#A0A3Q1M9F6-1", "sequence": { "sequence": "MLKFREAAKCVSGSIAVSTCPKSLIARRYMLQQKLGSGSFGTVFLVSDKKAKQGEELKVLKEICIGELNPNETVQATLEAQLLSKLNHPAIVKFHANFVEQDKFCIITEYCEGRDLDCKIQEYKEAGKTFPESQIIEWFIQLLLGVDYMHERKILHRDLKSKNIFLKNNKLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFTGSNFLSIVLKIVEGDTPSLPERYPRQLNAIMESMLNKSPSLRPSAIEILKLPYIDEQLQDLMCRYSEMALEDKNLNSQEEATYIINAVQKKIHLQTLRALSEVQKMTPRERMRVRKVQAADEEARKLKRLVEEKYEENNKRMRELRSRNFQRQTVDVLHKKIEHLMGMEEKERQPERRSCPLEEDGERRPGRVEECDDPASDNLPESQPIPSLDLCTLGSNVEDTIADLGDHATNS", "length": 469, "header": "tr|A0A3Q1M9F6-1|A0A3Q1M9F6_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek11 OS=Bos taurus OX=9913 GN=NEK11 PE=3 SV=2 CANONICAL=A0AAA9S9A9-1" }, "locus": { "chromosome": "1", "start_pos": 138835180, "end_pos": 138709120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082686.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082686.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065076.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065076.2" } ] } }, { "isoform_ac": "A0A3Q1MHW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#A0A3Q1MHW8-1", "sequence": { "sequence": "MLKFREAAKCVSGSIAVSTCPKSLIARRYMLQQKLGSGSFGTVFLVSDKKAKQGEELKVLKEICIGELNPNETVQATLEAQLLSKLNHPAIVKFHANFVEQDKFCIITEYCEGRDLDCKIQEYKEAGKTFPESQIIEWFIQLLLGVDYMHERKILHRDLKSKNIFLKNNKLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFTGSNFLSIVLKIVEGDTPSLPERYPRQLNAIMESMLNKSPSLRPSAIEILKLPYIDEQLQDLMCRYSEMALEDKNLNSQEEATYIINAVQKKIHLQTLRALSEVQKMTPRERMRVRKVQAADEEARKLKRLVEEKYEENNKRMRELRSRNFQRQTVDVLHECDDPASDNLPESQPIPSLDLCTLGSNVEDTIADLGDHEIPEDPLVAEEYYADVFDSCSEESEESEEGKTVFSVKDEEVEDEGPQPVYRTNQQDSDTEALARCLEHVLGCTTLDTRTVTSSAPDTPSEPTIFNSAMARTRMKHMRESAVQKLGAEVFEEVYSYLKRARQQGASEAEVWAALETVVPRASDCFEVDQLLYFEEQLLITRAEGVTLPQNHHEATVRSKQVPVDKAPVKIHQHCR", "length": 634, "header": "tr|A0A3Q1MHW8-1|A0A3Q1MHW8_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek11 OS=Bos taurus OX=9913 GN=NEK11 PE=3 SV=2 CANONICAL=A0AAA9S9A9-1" }, "locus": { "chromosome": "1", "start_pos": 138835180, "end_pos": 138565356, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073290.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073290.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073895.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073895.2" } ] } }, { "isoform_ac": "A0AAA9S9A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#A0AAA9S9A9-1", "sequence": { "sequence": "MLKFREAAKCVSGSIAVSTCPKSLIARRYMLQQKLGSGSFGTVFLVSDKKAKQGEELKVLKEICIGELNPNETVQATLEAQLLSKLNHPAIVKFHANFVEQDKFCIITEYCEGRDLDCKIQEYKEAGKTFPESQIIEWFIQLLLGVDYMHERKILHRDLKSKNIFLKNNKLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFTGSNFLSIVLKIVEGDTPSLPERYPRQLNAIMESMLNKSPSLRPSAIEILKLPYIDEQLQDLMCRYSEMALEDKNLNSQEEATYIINAVQKKIHLQTLRALSEVQKMTPRERMRVRKVQAADEEARKLKRLVEEKYEENNKRMRELRSRNFQRQTVDVLHKKIEHLMGMEEKERQPERRSCPLEEDGERRPGRVEECDDPASDNLPESQPIPSLDLCTLGSNVEDTIADLGDHEIPEDPLVAEEYYADVFDSCSEESEESEEGKTVFSVKDEEVEDEGPQPVYRTNQQDSDTEALARCLEHVLGCTTLDTRTVTSSAPDTPSEPTIFNSAMARTRMKHMRESAVQKLGAEVFEEVYSYLKRARQQGASEAEVWAALETVVPRASDCFEVDQLLYFEEQLLITRAEGVTLPQNHHE", "length": 647, "header": "tr|A0AAA9S9A9-1|A0AAA9S9A9_BOVIN Isoform 1 of Serine/threonine-protein kinase Nek11 OS=Bos taurus OX=9913 GN=NEK11 PE=3 SV=2 CANONICAL=A0AAA9S9A9-1" }, "locus": { "chromosome": "1", "start_pos": 138835180, "end_pos": 138565422, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115351.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115351.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080515.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080515.2" } ] } }, { "isoform_ac": "E1BJU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9/entry#E1BJU4-1", "sequence": { "sequence": "MLKFREAAKCVSGSIAVSTCPKSLIARRYMLQQKLGSGSFGTVFLVSDKKAKQGEELKVLKEICIGELNPNETVQATLEAQLLSKLNHPAIVKFHANFVEQDKFCIITEYCEGRDLDCKIQEYKEAGKTFPESQIIEWFIQLLLGVDYMHERKILHRDLKSKNIFLKNNKLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFTGSNFLSIVLKIVEGDTPSLPERYPRQLNAIMESMLNKSPSLRPSAIEILKLPYIDEQLQDLMCRYSEMALEDKNLNSQEEATYIINAVQKKIHLQTLRALSEVQKMTPRERMRVRKVQAADEEARKLKRLVEEKYEENNKRMRELRSRNFQRQTVDVLHKKIEHLMGMEEKERQPERRSCPLEEDGERRPGRVEECDDPASDNLPESQPIPSLDLCTLGSNVEDTIADLGDHEIPEDPLVAEEYYADVFDSCSEESEESEEGKTVFSVKDEEVEDEGPQPVYRTNQQDSDTEALARCLEHVLGCTTLDPLCRSWERRCLRRSTVTSREQGSREPARQRSGQLWKQWYLEPVTVLRLTNYSTLRSSC", "length": 599, "header": "tr|E1BJU4-1|E1BJU4_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek11 OS=Bos taurus OX=9913 GN=NEK11 PE=3 SV=4 CANONICAL=A0AAA9S9A9-1" }, "locus": { "chromosome": "1", "start_pos": 138835180, "end_pos": 138565469, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012197.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012197.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012197.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012197.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-69601", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "resource": "Reactome", "description": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitotic intra-S DNA damage checkpoint signaling", "id": "GO:0031573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031573", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" }, { "name": "regulation of mitotic cell cycle phase transition", "id": "GO:1901990", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901990", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-9943676", "name": "NEK11 phosphorylates CDC25A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-BTA-9943711" ], "enzyme_list": [ "A7MBD1-1", "A0AAA9S9A9-1" ], "evidence": [ { "id": "R-BTA-9943676", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9943676" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-9943711", "participant_name": "phospho-CDC25A [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000099007", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000009586", "database": "ENSEMBL", "url": "" }, { "id": "27062", "database": "VGNC", "url": "" }, { "id": "A7MBD1", "database": "UniProt", "url": "" }, { "id": "NP_001094570.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000098992", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 287, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 269, "end_pos": 271 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S9X4-1", "uniprot_ac": "A0AAA9S9X4", "uniprot_id": "A0AAA9S9X4_BOVIN", "mass": { "chemical_mass": 152639.0, "monoisotopic_mass": 152639.0 }, "refseq": {}, "gene_names": [ { "name": "CEMIP", "type": "recommended", "evidence": [ { "id": "A0AAA9S9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ] } ], "protein_names": [ { "name": "hyaluronoglucosaminidase", "type": "recommended", "evidence": [ { "id": "A0AAA9S9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.35", "type": "synonym", "evidence": [ { "id": "A0AAA9S9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEMIP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4", "locus": { "chromosome": "21", "start_pos": 26792143, "end_pos": 26633806, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007431", "url": "https://www.ensembl.org/id/ENSBTAG00000007431" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007431", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007431", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13938", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13938", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NM28", "url": "https://www.orthodb.org/?gene=A0A3Q1NM28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKX1", "url": "https://www.orthodb.org/?gene=E1BKX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15535", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15535", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15535:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15535:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13330", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13330", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15711", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15711", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24606", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24606", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2160916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NM28", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NM28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NM28-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NM28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SER6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SER6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SER6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SER6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKX1", "url": "https://www.uniprot.org/uniprotkb/E1BKX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BKX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAAHRPDVSFRVMLTIGWFILAHFPGTASTGSAECPDQWPELQPWNPGHDPAHYVYIGQGRALLLTSSATVYSIRISDGGKLVIKDQDEAIVLRTRHILIDSGGELHAGSALCPFQGNFSIVLYGRADDGIQLDPYFGLKYIGVDRGGTLELHGQKKLSWTFLNKTLHPGGLEEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLAQYLNAVPDGRILSVAVNDEGSRNLDDVARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHHGSAAARVFKLFRTEHGELFNVSSSSEWVQDVEWTEWFEHDQVSYTKGGEKISDLGVTHPGKICNRPIDIQATTLDGVNLTTEVVYKRGQDYRFVCYDRGQACQSYRVRFLCGKPVRPKLTVTIDTNVNSTILHLEDNVQSWKPGDTLVVASTDYSMYQAEEFQVLPCRTCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIVVMGEMEAECYPYSNHLCNFFDFDTFGGHIKFALGFKAAHLEGVELKHMGQQLIGQYPIHFHLAGDVDEKGGYDPPTYVKDLSIHHTFSRCVTVHGSNGLLVKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKTITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSAGMYSPGYSEHIPLGKFLNNRAHSNYRAGMIIDNGVKTTQASAKDKRPFLSIISARYSPHQDADPLKPREPAIIKHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKTNNLRMKIIKNDFPNHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPSELTIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGIFVKTSQMDKVEQSHPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSVKGCERIKIKALIPKNAGISDCAATAYPKFTEKAIVDVPMPKKLFGSLLTKDHFLEVKMESAKQRFFHLLNDLAYIQVDGKKYPSLEDGIQVVVIDGRHGQVLNHTGFRNAILQGIPWQLFNYVATIPDNSIVLMASKGRYTSRGPWTRVLEKLGAHKGLKLKEKMVFVGFKGSFRPTWVTLDTEDHHAKIFQVVPIPVVRKKKL", "length": 1360, "header": "tr|A0AAA9S9X4-1|A0AAA9S9X4_BOVIN Isoform 1 of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP PE=3 SV=1 CANONICAL=A0AAA9S9X4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NM28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4/entry#A0A3Q1NM28-1", "sequence": { "sequence": "MLRALCLPPQPPQRTCAGGTRHKARAFCFRPSCLLRLTELTQSTSPGAGREHSARMGAAHRPDVSFRVMLTIGWFILAHFPGTASTGNSSLGERKQSHHWTGSAECPDQWPELQPWNPGHDPAHYVYIGQGRALLLTSSATVYSIRISDGGKLVIKDQDEAIVLRTRHILIDSGGELHAGSALCPFQGNFSIVLYGRADDGIQLDPYFGLKYIGVDRGGTLELHGQKKLSWTFLNKTLHPGGLEEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLAQYLNAVPDGRILSVAVNDEGSRNLDDVARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHHGSAAARVFKLFRTEHGELFNVSSSSEWVQDVEWTEWFEHDQVSYTKGGEKISDLGVTHPGKICNRPIDIQATTLDGVNLTTEVVYKRGQDYRFVCYDRGQACQSYRVRFLCGKPVRPKLTVTIDTNVNSTILHLEDNVQSWKPGDTLVVASTDYSMYQAEEFQVLPCRTCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIVVMGEMEAECYPYSNHLCNFFDFDTFGGHIKFALGFKAAHLEGVELKHMGQQLIGQYPIHFHLAGDVDEKGGYDPPTYVKDLSIHHTFSRCVTVHGSNGLLVKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKTITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSAGMYSPGYSEHIPLGKFLNNRAHSNYRAGMIIDNGVKTTQASAKDKRPFLSIISARYSPHQDADPLKPREPAIIKHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKTNNLRMKIIKNDFPNHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPSELTIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGIFVKTSQMDKVEQSHPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSVKGCERIKIKALIPKNAGISDCAATAYPKFTEKAIVDVPMPKKLFGSLLKTKDHFLEVKMESAKQRFFHLLNDLAYIQVDGKKYPSLEDGIQVVVIDGRHGQVLNHTGFRNAILQGIPWQLFNYVATIPDNSIVLMASKGRYTSRGPWTRVLEKLGAHKGLKLKEKMVFVGFKGSFRPTWVTLDTEDHHAKIFQVVPIPVVRKKKL", "length": 1431, "header": "tr|A0A3Q1NM28-1|A0A3Q1NM28_BOVIN Computationally mapped isoform of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP PE=3 SV=2 CANONICAL=A0AAA9S9X4-1" }, "locus": { "chromosome": "21", "start_pos": 26791139, "end_pos": 26724115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067950.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067950.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073581.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073581.2" } ] } }, { "isoform_ac": "A0AAA9S9X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4/entry#A0AAA9S9X4-1", "sequence": { "sequence": "MGAAHRPDVSFRVMLTIGWFILAHFPGTASTGSAECPDQWPELQPWNPGHDPAHYVYIGQGRALLLTSSATVYSIRISDGGKLVIKDQDEAIVLRTRHILIDSGGELHAGSALCPFQGNFSIVLYGRADDGIQLDPYFGLKYIGVDRGGTLELHGQKKLSWTFLNKTLHPGGLEEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLAQYLNAVPDGRILSVAVNDEGSRNLDDVARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHHGSAAARVFKLFRTEHGELFNVSSSSEWVQDVEWTEWFEHDQVSYTKGGEKISDLGVTHPGKICNRPIDIQATTLDGVNLTTEVVYKRGQDYRFVCYDRGQACQSYRVRFLCGKPVRPKLTVTIDTNVNSTILHLEDNVQSWKPGDTLVVASTDYSMYQAEEFQVLPCRTCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIVVMGEMEAECYPYSNHLCNFFDFDTFGGHIKFALGFKAAHLEGVELKHMGQQLIGQYPIHFHLAGDVDEKGGYDPPTYVKDLSIHHTFSRCVTVHGSNGLLVKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKTITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSAGMYSPGYSEHIPLGKFLNNRAHSNYRAGMIIDNGVKTTQASAKDKRPFLSIISARYSPHQDADPLKPREPAIIKHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKTNNLRMKIIKNDFPNHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPSELTIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGIFVKTSQMDKVEQSHPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSVKGCERIKIKALIPKNAGISDCAATAYPKFTEKAIVDVPMPKKLFGSLLTKDHFLEVKMESAKQRFFHLLNDLAYIQVDGKKYPSLEDGIQVVVIDGRHGQVLNHTGFRNAILQGIPWQLFNYVATIPDNSIVLMASKGRYTSRGPWTRVLEKLGAHKGLKLKEKMVFVGFKGSFRPTWVTLDTEDHHAKIFQVVPIPVVRKKKL", "length": 1360, "header": "tr|A0AAA9S9X4-1|A0AAA9S9X4_BOVIN Isoform 1 of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP PE=3 SV=1 CANONICAL=A0AAA9S9X4-1" }, "locus": { "chromosome": "21", "start_pos": 26791139, "end_pos": 26725980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094199.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094199.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082106.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082106.1" } ] } }, { "isoform_ac": "A0AAA9SER6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4/entry#A0AAA9SER6-1", "sequence": { "sequence": "MGAAHRPDVSFRVMLTIGWFILAHFPGTASTGSAECPDQWPELQPWNPGHDPAHYVYIGQGRALLLTSSATVYSIRISDGGKLVIKDQDEAIVLRTRHILIDSGGELHAGSALCPFQGNFSIVLYGRFDTYRSKKESERLAQYLNAVPDGRILSVAVNDEGSRNLDDVARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHHGSAAARVFKLFRTEHGELFNVSSSSEWVQDVEWTEWFEHDQVSYTKGGEKISDLGVTHPGKICNRPIDIQATTLDGVNLTTEVVYKRGQDYRFVCYDRGQACQSYRVRFLCGKPVRPKLTVTIDTNVNSTILHLEDNVQSWKPGDTLVVASTDYSMYQAEEFQVLPCRTCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIVVMGEMEAECYPYSNHLCNFFDFDTFGGHIKFALGFKAAHLEGVELKHMGQQLIGQYPIHFHLAGDVDEKGGYDPPTYVKDLSIHHTFSRCVTVHGSNGLLVKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKTITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSAGMYSPGYSEHIPLGKFLNNRAHSNYRAGMIIDNGVKTTQASAKDKRPFLSIISARYSPHQDADPLKPREPAIIKHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKTNNLRMKIIKNDFPNHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPSELTIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGIFVKTSQMDKVEQSHPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSVKGCERIKIKALIPKNAGISDCAATAYPKFTEKAIVDVPMPKKLFGSLLTKDHFLEVKMESAKQRFFHLLNDLAYIQVDGKKYPSLEDGIQVVVIDGRHGQVLNHTGFRNAILQGIPWQLFNYVATIPDNSIVLMASKGRYTSRGPWTRVLEKLGAHKGLKLKEKMVFVGFKGSFRPTWVTLDTEDHHAKIFQVVPIPVVRKKKL", "length": 1281, "header": "tr|A0AAA9SER6-1|A0AAA9SER6_BOVIN Computationally mapped isoform of Cell migration inducing hyaluronidase 1 OS=Bos taurus OX=9913 GN=CEMIP PE=3 SV=1 CANONICAL=A0AAA9S9X4-1" }, "locus": { "chromosome": "21", "start_pos": 26791139, "end_pos": 26725980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125019.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125019.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080893.1" } ] } }, { "isoform_ac": "E1BKX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4/entry#E1BKX1-1", "sequence": { "sequence": "MGSRGPEKHMPGEHSARMGAAHRPDVSFRVMLTIGWFILAHFPGTASTGSAECPDQWPELQPWNPGHDPAHYVYIGQGRALLLTSSATVYSIRISDGGKLVIKDQDEAIVLRTRHILIDSGGELHAGSALCPFQGNFSIVLYGRADDGIQLDPYFGLKYIGVDRGGTLELHGQKKLSWTFLNKTLHPGGLEEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLAQYLNAVPDGRILSVAVNDEGSRNLDDVARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHHGSAAARVFKLFRTEHGELFNVSSSSEWVQDVEWTEWFEHDQVSYTKGGEKISDLGVTHPGKICNRPIDIQATTLDGVNLTTEVVYKRGQDYRFVCYDRGQACQSYRVRFLCGKPVRPKLTVTIDTNVNSTILHLEDNVQSWKPGDTLVVASTDYSMYQAEEFQVLPCRTCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIVVMGEMEAECYPYSNHLCNFFDFDTFGGHIKFALGFKAAHLEGVELKHMGQQLIGQYPIHFHLAGDVDEKGGYDPPTYVKDLSIHHTFSRCVTVHGSNGLLVKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKTITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSAGMYSPGYSEHIPLGKFLNNRAHSNYRAGMIIDNGVKTTQASAKDKRPFLSIISARYSPHQDADPLKPREPAIIKHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKTNNLRMKIIKNDFPNHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPSELTIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGIFVKTSQMDKVEQSHPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSVKGCERIKIKALIPKNAGISDCAATAYPKFTEKAIVDVPMPKKLFGSLLKTKDHFLEVKMESAKQRFFHLLNDLAYIQVDGKKYPSLEDGIQVVVIDGRHGQVLNHTGFRNAILQGIPWQLFNYVATIPDNSIVLMASKGRYTSRGPWTRVLEKLGAHKGLKLKEKMVFVGFKGSFRPTWVTLDTEDHHAKIFQVVPIPVVRKKKL", "length": 1378, "header": "tr|E1BKX1-1|A0AAA9S9X4_BOVIN Computationally mapped isoform of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP PE=3 SV=2 CANONICAL=A0AAA9S9X4-1" }, "locus": { "chromosome": "21", "start_pos": 26791139, "end_pos": 26723633, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009776.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009776.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009776.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009776.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2160916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "resource": "Reactome", "description": "Hyaluronan degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "clathrin-coated vesicle membrane", "id": "GO:0030665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030665", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "clathrin-coated endocytic vesicle", "id": "GO:0045334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "positive regulation of release of sequestered calcium ion into cytosol", "id": "GO:0051281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "positive regulation of protein targeting to membrane", "id": "GO:0090314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090314", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "hyaluronan catabolic process", "id": "GO:0030214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "hyalurononglucosaminidase activity", "id": "GO:0004415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004415", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "clathrin heavy chain binding", "id": "GO:0032050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "ER retention sequence binding", "id": "GO:0046923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" }, { "name": "hydrolase activity, acting on glycosyl bonds", "id": "GO:0016798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016798", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1259, "end_pos": 1261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 889, "end_pos": 891, "annotation": "n_glycosylation_sequon" }, { "start_pos": 921, "end_pos": 923, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-5693356", "name": "CEMIP hydrolyzes HA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [ "R-ALL-2160894" ], "enzyme_list": [ "A0AAA9S9X4-1" ], "evidence": [ { "id": "R-BTA-5693356", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693356" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2160894", "participant_name": "(HA)50 [plasma membrane]", "crossref": [ { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S9X4", "gene_name": "CEMIP", "activity": [ { "ec_number": "3.2.1.35", "activity": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "A0AAA9S9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ] }, { "ec_number": "3.2.1.35", "activity": "", "evidence": [ { "id": "A0AAA9S9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X4" }, { "id": "PS51484", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51484" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G8", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 166, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.35", "ec_name": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "3.2.1.35", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.35" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 1259, "end_pos": 1261 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 889, "end_pos": 891 }, { "start_pos": 921, "end_pos": 923 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S6N0-1", "uniprot_ac": "A0AAA9S6N0", "uniprot_id": "A0AAA9S6N0_BOVIN", "mass": { "chemical_mass": 112768.0, "monoisotopic_mass": 112768.0 }, "refseq": { "ac": "XP_010814854", "name": "caspase recruitment domain-containing protein 14 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814854" }, "gene_names": [ { "name": "CARD14", "type": "recommended", "evidence": [ { "id": "A0AAA9S6N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ] }, { "name": "CARD14", "type": "synonym", "evidence": [ { "id": "XP_010814854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814854" } ] } ], "protein_names": [ { "name": "Caspase recruitment domain-containing protein 14", "type": "recommended", "evidence": [ { "id": "A0AAA9S6N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0/entry#names_and_taxonomy" } ] }, { "name": "caspase recruitment domain-containing protein 14 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010814854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814854" } ] } ], "function": [ { "annotation": "Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "E1BHS1", "url": "https://www.uniprot.org/uniprotkb/E1BHS1#function" }, { "database": "UniProtKB", "id": "ARBA00058570", "url": "https://www.uniprot.org/uniprotkb/ARBA00058570#function" }, { "database": "UniProtKB", "id": "A0A3Q1MGF0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGF0#function" }, { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0#function" }, { "database": "UniProtKB", "id": "A0AAA9STD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CARD14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0", "locus": { "chromosome": "19", "start_pos": 52430398, "end_pos": 52460270, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015261", "url": "https://www.ensembl.org/id/ENSBTAG00000015261" } ] } } ], "crossref": [ { "id": "A0AAA9S6N0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S6N0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015261", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015261", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06736", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06736", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523360", "url": "https://www.ncbi.nlm.nih.gov/gene/523360", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523360", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523360", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BHS1", "url": "https://www.orthodb.org/?gene=E1BHS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14559", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14559", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14559:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14559:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010814854", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814854", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGF0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGF0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRV5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRV5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHS1", "url": "https://www.uniprot.org/uniprotkb/E1BHS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHS1-1", "url": "https://www.uniprot.org/uniprotkb/E1BHS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLAEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGPKQEVGAREPCPKGKQRLVRMFALCPRDDSNGSSSESQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCFSSGCPEILEVDQGGSLGAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKSSGGAQKLVRIVSMDRTKASPLWSSFEGSQLDPSRVEDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKKALQRLGTTEDQLLEAARQEEAELDKVPCLYSSLAPESWSDLDALLGCVRLAITDEQRKVVWTE", "length": 997, "header": "tr|A0AAA9S6N0-1|A0AAA9S6N0_BOVIN Isoform 1 of Caspase recruitment domain-containing protein 14 OS=Bos taurus OX=9913 GN=CARD14 PE=4 SV=1 CANONICAL=A0AAA9S6N0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0/entry#A0A3Q1MGF0-1", "sequence": { "sequence": "MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLAEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGVSAQEVGAREPCPKGKQRLVRMFALCPRDDSNGSSSESQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCFSSGCPEILEVDQGGSLGAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKQSSGGAQKLVRIVSMDRTKASPLWSSFEGSQLDPSRVEGEVDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKKALQRLGTTEDQLLEAARQEEAELDKVPCLYSSLAPESWSDLDALLGCVRLAITDEQRKVVWTE", "length": 1002, "header": "tr|A0A3Q1MGF0-1|A0AAA9S6N0_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 14 OS=Bos taurus OX=9913 GN=CARD14 PE=4 SV=1 CANONICAL=A0AAA9S6N0-1" }, "locus": { "chromosome": "19", "start_pos": 52452126, "end_pos": 52431402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068087.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068087.2" } ] } }, { "isoform_ac": "A0A3Q1MRV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0/entry#A0A3Q1MRV5-1", "sequence": { "sequence": "MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLAEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGPKQEVGAREPCPKGKQRLVRMFALCPRDDSNGSSSESQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCFSSGCPEILEVDQGGSLGAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKQSSGGAQKLVRIVSMDRTKASPLWSSFEGSQLDPSRVEDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKTKVLQPAPRSNPEDSKEGSAAARYHRGPAPGGRQAGGG", "length": 972, "header": "tr|A0A3Q1MRV5-1|A0AAA9S6N0_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 14 OS=Bos taurus OX=9913 GN=CARD14 PE=4 SV=1 CANONICAL=A0AAA9S6N0-1" }, "locus": { "chromosome": "19", "start_pos": 52452126, "end_pos": 52431529, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074938.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074938.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074596.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074596.1" } ] } }, { "isoform_ac": "A0AAA9S6N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0/entry#A0AAA9S6N0-1", "sequence": { "sequence": "MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLAEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGPKQEVGAREPCPKGKQRLVRMFALCPRDDSNGSSSESQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCFSSGCPEILEVDQGGSLGAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKSSGGAQKLVRIVSMDRTKASPLWSSFEGSQLDPSRVEDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKKALQRLGTTEDQLLEAARQEEAELDKVPCLYSSLAPESWSDLDALLGCVRLAITDEQRKVVWTE", "length": 997, "header": "tr|A0AAA9S6N0-1|A0AAA9S6N0_BOVIN Isoform 1 of Caspase recruitment domain-containing protein 14 OS=Bos taurus OX=9913 GN=CARD14 PE=4 SV=1 CANONICAL=A0AAA9S6N0-1" }, "locus": { "chromosome": "19", "start_pos": 52452126, "end_pos": 52431402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112556.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112556.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081649.1" } ] } }, { "isoform_ac": "A0AAA9STD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0/entry#A0AAA9STD9-1", "sequence": { "sequence": "MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLAEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGSQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCFSSGCPEILEVDQGGSLGAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKQSSGGAQKLVRIVSMDRTKASPLWSSFEGSQLDPSRVEDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKKALQRLGTTEDQLLEAARQEEAELDKVPCLYSSLAPESWSDLDALLGCVRLAITDEQRKVVWTE", "length": 962, "header": "tr|A0AAA9STD9-1|A0AAA9STD9_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 14 OS=Bos taurus OX=9913 GN=CARD14 PE=4 SV=1 CANONICAL=A0AAA9S6N0-1" }, "locus": { "chromosome": "19", "start_pos": 52452126, "end_pos": 52431402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109786.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109786.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087404.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087404.1" } ] } }, { "isoform_ac": "E1BHS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0/entry#E1BHS1-1", "sequence": { "sequence": "MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLPFDRRSWGVGHPARTVPSFRKAEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGPKQEVGAREPCPKGKQRLVRMFALCPRDDSNGSSSESQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCFSSGCPEILEVDQGGSLGAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKQSSGGAQKLVRIVSMDRTKASPLWSSFEGSQLDPSRVEDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKKALQRLGTTEDQLLEAARQEEAELDKVPCLYSSLAPESWSDLDALLGCVRLAITDEQRKVVWTE", "length": 1019, "header": "tr|E1BHS1-1|E1BHS1_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 14 OS=Bos taurus OX=9913 GN=CARD14 PE=4 SV=2 CANONICAL=A0AAA9S6N0-1" }, "locus": { "chromosome": "19", "start_pos": 52452126, "end_pos": 52431402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020297.4", "url": "https://www.ensembl.org/id/ENSBTAT00000020297.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020297.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020297.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 597, "start_aa": "Thr", "end_pos": 597, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr597", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523360", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523360", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" }, { "name": "CARD domain binding", "id": "GO:0050700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 587, "end_pos": 589, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 734, "end_pos": 736, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S6N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" }, { "id": "PS50209", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50209" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CARD", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 107, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 855, "end_pos": 987, "start_aa": "Tyr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S6N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6N0" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 566, "end_pos": 656, "start_aa": "Gln", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 597 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 446, "end_pos": 448 }, { "start_pos": 587, "end_pos": 589 }, { "start_pos": 64, "end_pos": 66 }, { "start_pos": 734, "end_pos": 736 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S7C0-1", "uniprot_ac": "A0AAA9S7C0", "uniprot_id": "A0AAA9S7C0_BOVIN", "mass": { "chemical_mass": 16099.0, "monoisotopic_mass": 16099.0 }, "refseq": {}, "gene_names": [ { "name": "IL1F10", "type": "recommended", "evidence": [ { "id": "A0AAA9S7C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ] } ], "protein_names": [ { "name": "Interleukin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9S7C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.", "evidence": [ { "database": "UniProtKB", "id": "E1BD32", "url": "https://www.uniprot.org/uniprotkb/E1BD32#function" }, { "database": "UniProtKB", "id": "ARBA00034096", "url": "https://www.uniprot.org/uniprotkb/ARBA00034096#function" }, { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL1F10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0", "locus": { "chromosome": "11", "start_pos": 46771504, "end_pos": 46759723, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018012", "url": "https://www.ensembl.org/id/ENSBTAG00000018012" } ] } } ], "crossref": [ { "id": "A0AAA9S7C0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9S7C0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018012", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018012", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615702", "url": "https://www.ncbi.nlm.nih.gov/gene/615702", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615702", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615702", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QFYFEQS", "url": "https://omabrowser.org/oma/group/QFYFEQS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD32", "url": "https://www.orthodb.org/?gene=E1BD32", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10078", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10078", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10078:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10078:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00340", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00340", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9007892", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9007892", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9014826", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9014826", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD32", "url": "https://www.uniprot.org/uniprotkb/E1BD32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD32-1", "url": "https://www.uniprot.org/uniprotkb/E1BD32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLIKDAEQKALYMRDGQFLVGDPNADNCHAETICILPNRGLERTKFPIFLGVQGGSRCLACVETGEGPSLQLEDVNIEDLYKGGEEATRFTFFQRSSGPAFRLEAAAWPGWFLSGSSEPQQPLRLTKESEPSARTEFYFEQSR", "length": 144, "header": "tr|A0AAA9S7C0-1|A0AAA9S7C0_BOVIN Isoform 1 of Interleukin-1 OS=Bos taurus OX=9913 GN=IL1F10 PE=3 SV=1 CANONICAL=A0AAA9S7C0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0/entry#A0AAA9S7C0-1", "sequence": { "sequence": "MTLIKDAEQKALYMRDGQFLVGDPNADNCHAETICILPNRGLERTKFPIFLGVQGGSRCLACVETGEGPSLQLEDVNIEDLYKGGEEATRFTFFQRSSGPAFRLEAAAWPGWFLSGSSEPQQPLRLTKESEPSARTEFYFEQSR", "length": 144, "header": "tr|A0AAA9S7C0-1|A0AAA9S7C0_BOVIN Isoform 1 of Interleukin-1 OS=Bos taurus OX=9913 GN=IL1F10 PE=3 SV=1 CANONICAL=A0AAA9S7C0-1" }, "locus": { "chromosome": "11", "start_pos": 46771011, "end_pos": 46762328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095474.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095474.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081112.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081112.1" } ] } }, { "isoform_ac": "E1BD32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0/entry#E1BD32-1", "sequence": { "sequence": "MCSLPMAKYYIIKDAEQKALYMRDGQFLVGDPNADNCHAETICILPNRGLERTKFPIFLGVQGGSRCLACVETGEGPSLQLEDVNIEDLYKGGEEATRFTFFQRSSGPAFRLEAAAWPGWFLSGSSEPQQPLRLTKESEPSARTEFYFEQSR", "length": 152, "header": "tr|E1BD32-1|E1BD32_BOVIN Computationally mapped isoform of Interleukin-1 OS=Bos taurus OX=9913 GN=IL1F10 PE=3 SV=1 CANONICAL=A0AAA9S7C0-1" }, "locus": { "chromosome": "11", "start_pos": 46771011, "end_pos": 46767775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023975.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023975.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023975.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023975.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615702", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615702", "resource": "KEGG Pathway" }, { "id": "R-BTA-9007892", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9007892", "resource": "Reactome", "description": "Interleukin-38 signaling" }, { "id": "R-BTA-9014826", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9014826", "resource": "Reactome", "description": "Interleukin-36 pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A9I5-1", "protein_name": "Interleukin-1", "gene_name": "Il1f10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCSLPMARYYIIKDAYQKALYTRNGQLLVGDPDSENCEPEKVCVLPNRGLDRSKVPIFLGIQGGSCCLACVKTREGPLLQLEDVNIEDLYKGGEQTTRFTFFQRSLGSAFRLEAAACPGWFLCGPAEPQQPVQLIQESEPSTRTEFYFEQSR", "length": 152 }, "evidence": [ { "id": "A0AAA9S7C0", "url": "https://omabrowser.org/oma/group/A0AAA9S7C0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IHF9-1", "protein_name": "Interleukin-1", "gene_name": "Il1f10", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MCSLPMARYYIIKDAHQKVLYTRNGQLLVGDPDADNCSAEKICILPNRGLDRSKVPIFLGIQGGSCCLACVETREGPSLKLEDVSIEDLYKGGEQTTRFTFFQRSLGSAFRLEAAACPGWFLCGPVEPQQPVQLTKESEPSTLTEFYFEQSR", "length": 152 }, "evidence": [ { "id": "A0AAA9S7C0", "url": "https://omabrowser.org/oma/group/A0AAA9S7C0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8R459-1", "protein_name": "Interleukin-1 family member 10", "gene_name": "Il1f10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCSLPMARYYIIKDAHQKALYTRNGQLLLGDPDSDNYSPEKVCILPNRGLDRSKVPIFLGMQGGSCCLACVKTREGPLLQLEDVNIEDLYKGGEQTTRFTFFQRSLGSAFRLEAAACPGWFLCGPAEPQQPVQLTKESEPSTHTEFYFEMSR", "length": 152 }, "evidence": [ { "id": "A0AAA9S7C0", "url": "https://omabrowser.org/oma/group/A0AAA9S7C0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WWZ1-1", "protein_name": "Interleukin-1 family member 10", "gene_name": "IL1F10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW", "length": 152 }, "evidence": [ { "id": "A0AAA9S7C0", "url": "https://omabrowser.org/oma/group/A0AAA9S7C0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" }, { "name": "interleukin-1 receptor binding", "id": "GO:0005149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9S885-1", "uniprot_ac": "A0AAA9S885", "uniprot_id": "A0AAA9S885_BOVIN", "mass": { "chemical_mass": 276031.0, "monoisotopic_mass": 276031.0 }, "refseq": { "ac": "XP_010809977", "name": "centrosome-associated protein CEP250 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809977" }, "gene_names": [ { "name": "CEP250", "type": "recommended", "evidence": [ { "id": "A0AAA9S885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ] }, { "name": "CEP250", "type": "synonym", "evidence": [ { "id": "XP_010809977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809977" } ] } ], "protein_names": [ { "name": "Centrosomal protein 250", "type": "synonym", "evidence": [ { "id": "A0AAA9S885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885/entry#names_and_taxonomy" } ] }, { "name": "centrosome-associated protein CEP250 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010809977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809977" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP250", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885", "locus": { "chromosome": "13", "start_pos": 64747871, "end_pos": 64699760, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006021", "url": "https://www.ensembl.org/id/ENSBTAG00000006021" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507479", "url": "https://www.ncbi.nlm.nih.gov/gene/507479", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR055167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507479", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507479", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DQDLRHQ", "url": "https://omabrowser.org/oma/group/DQDLRHQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKP6", "url": "https://www.orthodb.org/?gene=E1BKP6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23159", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23159", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23159:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23159:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010809977", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010809977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S885-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NN27", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NN27-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKP6", "url": "https://www.uniprot.org/uniprotkb/E1BKP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKP6-1", "url": "https://www.uniprot.org/uniprotkb/E1BKP6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METGGPGLNNMKPRSLQLVLEEQVLALQQQMAENQAASWRKLKSSQEAQQRQAALVRKLQAKVLQYRSWCQELEKRLEATGCRCENLVEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLGLWREVVTFRRHFLEMKSATDRDLTELKAEHARLSGSLLTSCLRLTVGVPPSRESDGSGRLNGNEPSQLMLLLAKTQELEREAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRATMEILEANHAELMEHEASLSRNAQEEKLSLQQVIQDITQAMVEEEDSMAQGSSHESSLQLDPGGFSSRFDSQQPDKAVSLVRSVLTQRRQAVQDLRQQLSGCQEAVSSWQQQHHQWEEEGEALRQRLQQLTGERDTLAGQTVDLQGEVDSLSRERELLQKTREELQQQLEVLEQEAWRLRRTNMELQLQGDSAQGEKEEQQEELHLAVRERERLQETLVVLEARQSESLSELICLREALESSRLEGELLRQEQTEVTAALARAEQSIVELSSAENSLKAEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEQEKQSVCRRMEAAEQARSTLQVDLAEAERSREALWEKNSHLEAQLQKTEETRAELQADLRGIQEEKEEIQEKLSETYHQQEAASAQIEQLKQETTRQEEMLAREVQEKEALAREKAALEVRLQAVERDRQELAEQLLGLSSAKEVLESSLFEAQQQNSLTEVTKGQLEVQIQTVTQAKEVIQGEVKCLQLELDTERSRAEQARDTAARQLAQAEQEGQAALQQLKSAHEEEVNRLQEKWEEERSRHRQELEKVLESLEREKMELEARLREQQAEMEAMRAQREEERAEAESALCQMQLETEKERMSLLETLLQTQKELAEASQQLERLRQDMKVQQLKEQETTGMLQTQLQEAQQALEQAAQQHRDSLATLQQEGRVLLQDKTDLQKQVEDLKSQLLSKEASQRFVDQEVQEKLREAQECSRIQKELEREKASLTLSLVEKEQRLLVLQEADSVQQQELSSLRQDMQEAQAGQKELSTQVELLKQEVKEKEADFLAQETQLLEELEASRVTEQQLRASLWAQETKVAQLQLRLRSTESRLEALVAEQQPGHQAQVQLASLYSVLQQALGSACESRLELNGGGDSAPSLWGPEPDQNGARILFKRGPLLTALSVEAVAAALHKLHQDLWKTQQARDDLRDQAQKLEQRLSDMEAEKSQVHTELQALQRQLSQNEEEKSKWEGKQNSLESELMELRETVASLQSRLQQAELQGVEAQNERKLLQAAKESLTAQVEHLQASITEARAQASAAVALEEDLRMARSALKLKNEEVASERQRAQALQEQGELKVAQGKALQENLARLAQALSEREGEVETLQGKIEELEKQREMQKAVLEVLSLDLKKRNREVDLQQGQIQELEECRSVLEHLPVAVQEREQQLALQRERIRELEKDRETQTSILEHHLLELEKKVQVIESQKGQIQDLKKQLVTTECLALELEEKRHKTESQQKAIEELEGQREAQRVALTHLTLDLEERSQELLAQGNRIQELEGHSTLLASELQEKEQEAMAQQDQIRDLQRQKERLSQDLERREQELVLLKERTQSLEDQRSRQTKILEEDLEQIKLALRERGRELVSQRQLRQEWAEEGKGQSKAQRGSLEHMKLILRDKEKEVECQQEHIQELREHRDQLEQELQGLHRKVSETSLLLTQREQEIAVLQQHLQEAQDQGELKEQELQGQLEETQRVLVQRTQELQALQQQEAQDQEKNVKEQADSLQTALEQAHAALEERRAELEEHKEHARRLQEELAVEGRRSQALEEVLGDLRAEAREQEKVLRALQQQCADQAQEHEAEARGLRDSWLQAEALLDARDRELEALRAEGQASQRQEEAARGQAEALQKALGQAQAALREKEQHLHGQAELSRNLEASTATLQAALDSCQAQARQLEETLRKREGEIQDGDLRHQETVQQLQQALAQRDKELRELRRQGQLLEKSLAQEKQERRHEREGEEVRGLRESLRELQRTLAQKEDELLELREAQQRKDLEDAPHSHKTSPREEPSSPLDSSGPRLQRELERLQRALRQTEAREIEWREKAQHLALSLAQSKASVSSLQEAALLLQASVLERDSEQQRLQDELELTRQALEKERLHSLGLTSQAEQGPGGEPGIRLGEVSEVKMEPSPEAEEKQRWEQRLEHLQRAVAQLEVDRSRLQHHNTQLRTTLEQVERERRKLKRESMRASRAGVLESSGATTPSPTPQDGRGGQKVSSDATHMAELQKEVALLRAQLALERKQKQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPILLCRSPSPAQGASR", "length": 2408, "header": "tr|A0AAA9S885-1|A0AAA9S885_BOVIN Isoform 1 of Centrosomal protein 250 OS=Bos taurus OX=9913 GN=CEP250 PE=4 SV=1 CANONICAL=A0AAA9S885-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S885-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885/entry#A0AAA9S885-1", "sequence": { "sequence": "METGGPGLNNMKPRSLQLVLEEQVLALQQQMAENQAASWRKLKSSQEAQQRQAALVRKLQAKVLQYRSWCQELEKRLEATGCRCENLVEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLGLWREVVTFRRHFLEMKSATDRDLTELKAEHARLSGSLLTSCLRLTVGVPPSRESDGSGRLNGNEPSQLMLLLAKTQELEREAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRATMEILEANHAELMEHEASLSRNAQEEKLSLQQVIQDITQAMVEEEDSMAQGSSHESSLQLDPGGFSSRFDSQQPDKAVSLVRSVLTQRRQAVQDLRQQLSGCQEAVSSWQQQHHQWEEEGEALRQRLQQLTGERDTLAGQTVDLQGEVDSLSRERELLQKTREELQQQLEVLEQEAWRLRRTNMELQLQGDSAQGEKEEQQEELHLAVRERERLQETLVVLEARQSESLSELICLREALESSRLEGELLRQEQTEVTAALARAEQSIVELSSAENSLKAEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEQEKQSVCRRMEAAEQARSTLQVDLAEAERSREALWEKNSHLEAQLQKTEETRAELQADLRGIQEEKEEIQEKLSETYHQQEAASAQIEQLKQETTRQEEMLAREVQEKEALAREKAALEVRLQAVERDRQELAEQLLGLSSAKEVLESSLFEAQQQNSLTEVTKGQLEVQIQTVTQAKEVIQGEVKCLQLELDTERSRAEQARDTAARQLAQAEQEGQAALQQLKSAHEEEVNRLQEKWEEERSRHRQELEKVLESLEREKMELEARLREQQAEMEAMRAQREEERAEAESALCQMQLETEKERMSLLETLLQTQKELAEASQQLERLRQDMKVQQLKEQETTGMLQTQLQEAQQALEQAAQQHRDSLATLQQEGRVLLQDKTDLQKQVEDLKSQLLSKEASQRFVDQEVQEKLREAQECSRIQKELEREKASLTLSLVEKEQRLLVLQEADSVQQQELSSLRQDMQEAQAGQKELSTQVELLKQEVKEKEADFLAQETQLLEELEASRVTEQQLRASLWAQETKVAQLQLRLRSTESRLEALVAEQQPGHQAQVQLASLYSVLQQALGSACESRLELNGGGDSAPSLWGPEPDQNGARILFKRGPLLTALSVEAVAAALHKLHQDLWKTQQARDDLRDQAQKLEQRLSDMEAEKSQVHTELQALQRQLSQNEEEKSKWEGKQNSLESELMELRETVASLQSRLQQAELQGVEAQNERKLLQAAKESLTAQVEHLQASITEARAQASAAVALEEDLRMARSALKLKNEEVASERQRAQALQEQGELKVAQGKALQENLARLAQALSEREGEVETLQGKIEELEKQREMQKAVLEVLSLDLKKRNREVDLQQGQIQELEECRSVLEHLPVAVQEREQQLALQRERIRELEKDRETQTSILEHHLLELEKKVQVIESQKGQIQDLKKQLVTTECLALELEEKRHKTESQQKAIEELEGQREAQRVALTHLTLDLEERSQELLAQGNRIQELEGHSTLLASELQEKEQEAMAQQDQIRDLQRQKERLSQDLERREQELVLLKERTQSLEDQRSRQTKILEEDLEQIKLALRERGRELVSQRQLRQEWAEEGKGQSKAQRGSLEHMKLILRDKEKEVECQQEHIQELREHRDQLEQELQGLHRKVSETSLLLTQREQEIAVLQQHLQEAQDQGELKEQELQGQLEETQRVLVQRTQELQALQQQEAQDQEKNVKEQADSLQTALEQAHAALEERRAELEEHKEHARRLQEELAVEGRRSQALEEVLGDLRAEAREQEKVLRALQQQCADQAQEHEAEARGLRDSWLQAEALLDARDRELEALRAEGQASQRQEEAARGQAEALQKALGQAQAALREKEQHLHGQAELSRNLEASTATLQAALDSCQAQARQLEETLRKREGEIQDGDLRHQETVQQLQQALAQRDKELRELRRQGQLLEKSLAQEKQERRHEREGEEVRGLRESLRELQRTLAQKEDELLELREAQQRKDLEDAPHSHKTSPREEPSSPLDSSGPRLQRELERLQRALRQTEAREIEWREKAQHLALSLAQSKASVSSLQEAALLLQASVLERDSEQQRLQDELELTRQALEKERLHSLGLTSQAEQGPGGEPGIRLGEVSEVKMEPSPEAEEKQRWEQRLEHLQRAVAQLEVDRSRLQHHNTQLRTTLEQVERERRKLKRESMRASRAGVLESSGATTPSPTPQDGRGGQKVSSDATHMAELQKEVALLRAQLALERKQKQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPILLCRSPSPAQGASR", "length": 2408, "header": "tr|A0AAA9S885-1|A0AAA9S885_BOVIN Isoform 1 of Centrosomal protein 250 OS=Bos taurus OX=9913 GN=CEP250 PE=4 SV=1 CANONICAL=A0AAA9S885-1" }, "locus": { "chromosome": "13", "start_pos": 64746867, "end_pos": 64707426, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135945.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135945.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078366.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078366.1" } ] } }, { "isoform_ac": "A0ABI0NN27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885/entry#A0ABI0NN27-1", "sequence": { "sequence": "METGGPGLNNMKPRSLQLVLEEQVLALQQQMAENQAASWRKLKSSQEAQQRQAALVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWESVEKPNLEQLLIRLEEEQQRCENLVEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLGLWREVVTFRRHFLEMKSATDRDLTELKAEHARLSGSLLTSCLRLTVGVPPSRESDGSGRLNGNEPSQLMLLLAKTQELEREAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRATMEILVCDPLFCEGVGSGPVGSSFMDKE", "length": 340, "header": "tr|A0ABI0NN27-1|A0ABI0NN27_BOVIN Computationally mapped isoform of Centrosomal protein 250 OS=Bos taurus OX=9913 GN=CEP250 PE=4 SV=1 CANONICAL=A0AAA9S885-1" }, "locus": { "chromosome": "13", "start_pos": 64713413, "end_pos": 64707426, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140568.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140568.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104156.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104156.1" } ] } }, { "isoform_ac": "E1BKP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885/entry#E1BKP6-1", "sequence": { "sequence": "MEEAEELPGGPAEASSSREEAAGQGVTVPELVPGAGEAAGSHWGTDPSKVGKRGKAKPGTAANPIGRGTTECRCENLVEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLGLWREVVTFRRHFLEMKSATDRDLTELKAEHARLSGSLLTSCLRLTVGVPPSRESDGSGRLNGNEPSQLMLLLAKTQELEREAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRATMEILEANHAELMEHEASLSRNAQEEKLSLQQVIQDITQAMVEEEDSMAQGSSHESSLQLDPGGFSSRFDSQQPDKAVSLVRSVLTQRRQAVQDLRQQLSGCQEAVSSWQQQHHQWEEEGEALRQRLQQLTGERDTLAGQTVDLQGEVDSLSRERELLQKTREELQQQLEVLEQEAWRLRRTNMELQLQGDSAQGEKEEQQEELHLAVRERERLQETLVVLEARQSESLSELICLREALESSRLEGELLRQEQTEVTAALARAEQSIVELSSAENSLKAEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEQEKQSVCRRMEAAEQARSTLQVDLAEAERSREALWEKNSHLEAQLQKTEETRAELQADLRGIQEEKEEIQEKLSETYHQQEAASAQIEQLKQETTRQEEMLAREVQEKEALAREKAALEVRLQAVERDRQELAEQLLGLSSAKEVLESSLFEAQQQNSLTEVTKGQLEVQIQTVTQAKEVIQGEVKCLQLELDTERSRAEQARDTAARQLAQAEQEGQAALQQLKSAHEEEVNRLQEKWEEERSRHRQELEKVLESLEREKMELEARLREQQAEMEAMRAQREEERAEAESALCQMQLETEKERMSLLETLLQTQKELAEASQQLERLRQDMKVQQLKEQETTGMLQTQLQEAQQALEQAAQQHRDSLATLQQEGRVLLQDKTDLQKQVEDLKSQLLSKEASQRFVDQEVQEKLREAQECSRIQKELEREKASLTLSLVEKEQRLLVLQEADSVQQQELSSLRQDMQEAQAGQKELSTQVELLKQEVKEKEADFLAQETQLLEELEASRVTEQQLRASLWAQETKVAQLQLRLRSTESRLEALVAEQQPGHQAQVQLASLYSVLQQALGSACESRLELNGGGDSAPSLWGPEPDQNGARILFKRGPLLTALSVEAVAAALHKLHQDLWKTQQARDDLRDQAQKLEQRLSDMEAEKSQVHTELQALQRQLSQNEEEKSKWEGKQNSLESELMELRETVASLQSRLQQAELQGVEAQNERKLLQAAKESLTAQVEHLQASITEARAQASAAVALEEDLRMARSALKLKNEEVASERQRAQALQEQGELKVAQGKALQENLARLAQALSEREGEVETLQGKIEELEKQREMQKAVLEVLSLDLKKRNREVDLQQGQIQELEECRSVLEHLPVAVQEREQQLALQRERIRELEKDRETQTSILEHHLLELEKKVQVIESQKGQIQDLKKQLVTTECLALELEEKRHKTESQQKAIEELEGQREAQRVALTHLTLDLEERSQELLAQGNRIQELEGHSTLLASELQEKEQEAMAQQDQIRDLQRQKERLSQDLERREQELVLLKERTQSLEDQRSRQTKILEEDLEQIKLALRERGRELVSQRQLRQEWAEEGKGQSKAQRGSLEHMKLILRDKEKEVECQQEHIQELREHRDQLEQELQGLHRKVSETSLLLTQREQEIAVLQQHLQEAQDQGELKEQELQGQLEETQRVLVQRTQELQALQQQEAQDQEKNVKEQADSLQTALEQAHAALEERRAELEEHKEHARRLQEELAVEGRRSQALEEVLGDLRAEAREQEKVLRALQQQCADQAQEHEAEARGLRDSWLQAEALLDARDRELEALRAEGQASQRQEEAARGQAEALQKALGQAQAALREKEQHLHGQAELSRNLEASTATLQAALDSCQAQARQLEETLRKREGEIQDGDLRHQETVQQLQQALAQRDKELRELRRQGQLLEKSLAQEKQERRHEREGEEVRGLRESLRELQRTLAQKEDELLELREAQQRKDLEDAPHSHKTSPREEPSSPLDSSGPRLQRELERLQRALRQTEAREIEWREKAQHLALSLAQSKASVSSLQEAALLLQASVLERDSEQQRLQDELELTRQALEKERLHSLGLTSQAEQGPGGEPGIRLGEVSEVKMEPSPEAEEKQRWEQRLEHLQRAVAQLEVDRSRLQHHNTQLRTTLEQVERERRKLKRESMRASRAGVLESSGATTPSPTPQDGRGGQKVSSDATHMAELQKEVALLRAQLALERKQKQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPILLCRSPSPAQGASR", "length": 2398, "header": "tr|E1BKP6-1|E1BKP6_BOVIN Computationally mapped isoform of Centrosomal protein 250 OS=Bos taurus OX=9913 GN=CEP250 PE=4 SV=4 CANONICAL=A0AAA9S885-1" }, "locus": { "chromosome": "13", "start_pos": 64746867, "end_pos": 64707539, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007911.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007911.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007911.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007911.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2298, "start_aa": "Thr", "end_pos": 2298, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2298", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507479", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507479", "resource": "KEGG Pathway" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LVR8-1", "protein_name": "Centrosome-associated protein CEP250 isoform X1", "gene_name": "Cep250", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METGSPGLNMKPKSLQLVLEEQVLALQHQMAENQAASWQKLKNSQEAQKRQATLVRKLQAKVLQYRSWCQELEKRLEATGGLIPQRWEGVEEPNLEQLLVRLEEEQQRCESLVEVNTELRLHMEKADVVNKALREDVEKLTVDWSRARDELIRKESQWRLEQEFFKGYLKGEHDRLLNLWREVVTFRRHFLKMKSATDRDLTELKAEHAKLSGSLLTCCLRLTVRAQSRESSGSGRTENEPAQLLLLVAKTQALEKEAHEKSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMETLETNHAELMEHEVSLSRNAQEEMLSLQHVIKDIAQVLASVEEEDTVTHSSDHESSLQLDCSGFSPFDPQNPDKALTLVRSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHRQWEEEGEALRERLHKLTGERDALAGQTVDLQGEVDSLSKERELLQKARGELQEQLEVLEQEAWRLRRVNMELQLQGDSAQGEKQEQQEELHMAVRERELLQEMLVSLEAKQSESLSELMTLREALESSRLEGELLRQEQVEVTAAWARAEQSIAELSASENSLKAEVADLRAAAVKLGALNEALALDKVGLNQQLLQLEQENQSVCSRAEAAEHLRSALQVDLAEAERHREALWEKNTQLQTQLQKAEESGAELQAELKSIREEKEELKEKLSEAHHQQEAATAQLEQLHQDTERQQETLARAVQEKETLVRERATLEVRLQAVERDRQDLTEQVLGLRSAKEQLESNLFETQQQNSVIEVTKGQLEIQVQTITQAKEVIQGEVKCLKLELDAERSRAEQERDAVARQLAQAEQEGQAALEQQKVAHEEELNRLQEKWEKERSLLQQELEKALETLERERTELEVRLREQQTETEALRAQREEERTHADSTLYQMQLETEKERVSLLETLLQTQKELADATQQLERLRKDMKIQKLQEQETTDMLQTQLQGAQQELKEATQQHSEEHAAFRKDREDLQKQVEDLKSQLVTQDDSHRLVKQEIQEKMKEVQEYSRIQKELEKEKASLALSLVEKEGRLLILQEADSVRQQELNSLRQDIQEAQEGQRELSVQVELLRQEVKEKEADFVAREAQLLEELEASRITEQQLRASLWTQEAKTTQLQLQLRSTESQLEVLAAEQQPENQAQAQLASLYSVLQQALGSACESRPELRGGGDSAPSLWGPEPDQNGARRPFKRGSLLTALSAEAVALALQKLHQDLWKAQQARDDLRDQIQKLKQHLTDTEAQKSQVHSDLQDLQRQLSQSQEEKSKWEGKQNSLESELRDLHETVASLQSRLRQAELQKMEAQNEQELLQASKEKLTAQVERLQAFVAEAHAQASAASVLEEDLRTARSALKLKNEEVESERERAQALQEQSELKVAQGKALQENLALLAQTLSNREREVETLQTEIQELEKQREMQKAALELLSLDLKQRSQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQQLSVQQDQIRELEKDRETQRSVLEHQLLELEKKAQVIESQRGQIQDLKKQLVTLECLALELEESHHKVEGQQQVIAELESQREMQRVALTHLTLDLEERSQDLQAQSSQLHELESHGTHLARELQERDQEVKAQRQQIEELQKQKEQLTQDLERKGQELMLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERGQEMASQRQLMLERADNGQSPGKAQRGSLEHLKLILREKEKEVECQHERIQELEEHVGQVEQQLQGLHRKMGETSLLLTHREQEVATLQRHLQEAKDQGELKEQALQGQLEEAQRALAQRDQELEALQQEQQQTLAQEESMKQKTGALQAALEQAQVTLKERQGELEEHRERAQRLQEELVLEGRQVRALEEVLADLRSEIREHEKAVLALQQQCAEQAQEHEAEARTLQDSWLRAQATLSEQEQELAALRAENQYSRHQEEAAWGQAEALQEALSKAQAALQDKEQSLLEQAELSCTLEASTTALQASLDNCQSRARQLEEALKIREGEIQAQGLQHQEVTQQLQQALSQKEEKLRQQEEQRQLLEKALTQSSQENGIQEKQSLEQERKEDTGGLVASLRELQRTLAQKEEEILMLREAQQRQSLEASSPSHRAFPAEKPAPQLCQELERLQNALRQTEAREIEWREKAQDLARSLAQSKASNNSLQEIAMLLQASVLERESEQQRLQEELVLSRQALEEQQSHGSHSTSRADRGPKAGQDVHPGKVVVAEPSPGVEEKEQWTQRLERLQQAVAQLEFDRSKLQHHNAQLRITLELVERERRKLKRDSMRASRAGSLEMKEAMASSPAQQDGRAAQRGSSDSMRVVELQREVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETRKLDESLSQSLASPEPVLLHPSLDTAQTTPR", "length": 2425 }, "evidence": [ { "id": "A0AAA9S885", "url": "https://omabrowser.org/oma/group/A0AAA9S885/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZC94-1", "protein_name": "Centrosomal protein 250", "gene_name": "CEP250", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAREAARGQACLRRRLHGAEEAQQQQAVLVRKLQEKLLQYRSWCRELEQRLEAGGVSVQGSLSYRWETTEDHSLEKALLQLEEEQQRCENLAEVNTLLREHLDKANEVNLALKEDVGKLTADWMRAREELELKESEWRSEREFYDSYLRGEHNRLLSLWRQVLTFRRHFLEMKTATDRDLSELKAEQMRLSGSILVSCFRLNSGVQLWESVTLGRPVLKDQAQQQVEREINQEALEVMCLQVDEDLEKKELQDRVMELSALLVQSQKQNEEKEKTVKTLNDTVEMLEASRLEVEYEASLTKNAKEENLALQKLIKEITEVVLDDSDSTVGIVQRPESSNVLSCLSSLDAEHAFVLVQETLARRQKAIQALKEELSTRQDSISFLQHQHRQQEEKCKKLQQRLEQLEEENKMSNSHQQHLKSLVLALKCDCENLEKIRGELQQKLELSEQEASRLRQSNTELQLKEDSAQGEKVEQQLAMERAHHDHELVLKDLAALEEKHSLLQNELVAAREKLEESHLQRDLLKQEKHELTVALEKAEKSVAALTGAQNKLNSEIADLHTAAAKMSSINEALALDKVELNKLVLQLEQENELLSDKVNEMERAKVSEQEKITLYKRTNEELCAEKSHLEKLLKKAEEQQEELQMQLRILAEEKEETLEKLNQVYRQQESASSGLEQLRQQSSRQEDAVAKVSKEKEFLVHEKAALEVRLAAVERDRQGLSEQLAEARSVKDTLESSLFEAQQQLSHLEITKSQLEIQLHTVIQAKEVIQGEVKCLQYELETERCLMKQEQENMAQRLIQIEEQHNNTLKLQQTDHEVEINKLLQDLASEREGRQLELQEMLELWEKEKAEAEGQHEKKLFDMKEKVATMQAQQEEERTRVESANQEILTEKENEKKALLETLLQTQGELTEACHQLEQLRQEVKEQQEYEQNITEKLQAELQETHCKIKMVENMHKEEMENIKEEKNILLQQRDDLQKQVEELTSQLAASEESHQAIGHKAQQELSEAQELSRQKVLEVVHLQKILEEERGQWEEVEHQNKELQVCLQSLEGERSRWEEVERHNTEFQASLKALESERERLSLSLEQKELSLKTLEENNLVQQNEVSKLHSAIQQAQQLHSDHRREIQELNNQVQTLQEVVLEKEASLAAREKQLLQDLEESRAGERCLRDSLHVLEAEMAELHLRLCSTENRAKALATECQQANNAHCEAQSQLDKLHLVLHHVLCDSTDKSSDLVAWSSEQDHVWGLTVSQAKDLHVELTVDRVAAALQDLRQDLKQTQQDLNDAGKKVQDLELELSKRQAERDHFSAHNQELQKQLAQSQEETQMVEGKKNSLQAALQAEAAALKKEAITLHQEVASLERKLESAEKQKKDVLHERDRLQAVEEKLMWEIKILQESVTASETRANTAADMNHSLEQELQTTLSVLKTKNKEVDAQWEKIQMLQKEAADVKALQENLIQVNAILSKREGEMKLYQEQMRMLENQKEMHKTTLDQVIKDIKEKKEKTESQQEQIQELEKQQELQRTAISKMSKDLEDRDKEIRSQQEEIWELEKQQELQRTVVSKMTKDLAHRDQEIQSQQEEIQELEKERELQRTAASKMSKDLKERDEKIRSQQELIEELEKQQELQRTALSKMSKNLEERDQEIKSQQELIEELKKQQELQRTVVSRMSKNLEDRDQEIKSLQELIQELEKQREIQRTAVSKMNKDLEERDQEIRSQQEEIQELEKQRELQRTILSKMSKDLEEKDQVIKFQEGKVMILEQHGTSQVRSLLVDLDHMKGNLKEKNLELMSLNQQIKELEMEREEVKSLHTSLEQLRAVLRDRENESDSQRDQLRLFQQYKEHQEEYLQELQDKVEKMTLSLSKKDQELESQQKQIQEAEEVMEKKLKTVCDQLEQTLETLKEKERLLDIQKQQTREYEEKTEQMNVLCRDLEYTKAILREKDLMIESQKELIETFQKQEDDSMQQKEILQHLKGALKEQEQETLSLRKQCEAFKEKEEKHKTDQVILQETKITLKERERKIEVLEKAVSKLQQQNDDTMMQTTAIVQKLQCAESSLAARDQEIASLKEHVQELQKQKESEAKQVKSLQQDLNKMSKTMKKNNLQILKQSEQINVFHICEESRKVALTSCQNQVSLLEEVVRKRDEDNETLVQKLQHQEEELKTLQNLQLMLSEKKEEIKRHREEEKFPEEALHGSEWETKAQGEQKKSEDEEIRGLHEDLQYVQQTLTKKDEEIKYQRDRVKYLEKTLAGKEKELRRQSELLKQLTSALHWKDEGETLKKQIQKLQKWEEEEAENRRVLQERDQFLQRQKELAQQLEDERKVKGEELKRVIAILKQTESGEIEWKEKAQALTLALSKSEMTNGTLREEIAILQSMVSERDKDRFHLQEAFEGGENLSWLLEKKLLWQRLECLQQAVARLEHEKSELKQLNVELKITLEQVEHERRRLKRSCRRQSQPNANRFSLSESDEDKMPASRKEEARALCSQLAELQNQVTLLQQQLAQERKYKQDYIECCAKTSQELLDLHQELSYSLEAVIREPKAAVLEAETQKLDLSLNHTLALISLDCRSPERQLLHSAVRSTTRDGLR", "length": 2594 }, "evidence": [ { "id": "A0AAA9S885", "url": "https://omabrowser.org/oma/group/A0AAA9S885/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M7J7-1", "protein_name": "Centrosomal protein 250", "gene_name": "Cep250", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METGSPGLNMKPQSLQLVLEEQVLALQQQMAQNQAASWRKLKNSQEAQKRQATLVRKLQAKVLQYRSWCQDLEKRLEATGGLIPQRWESVEEPNLEQLLIRLEEEQQRCESLVEVNTELRLHMEKADVVNKALQEDVEKLTVDWSRARDELMRKESQWRMEQEFFKGYLRGEHGRLLSVWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQSRDSSGSGRSDESEPAQLLLLVAKTQALEKEAHEKSQELMQLKSQGDLEKAELQDRVTELSALLTQSQKQNKDYEEMVKALRGTMEILETNHAELMEHEASLSRNAQEEKLSLQHVIKDITQALASVEEEDTVTQTPGSENSLQSDYNDLSQFDSQDPNKALTLVHSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHNQWEEEGKALRERLQKLTGERDALAGQTVDLQGEVDSLSKERELLQTARGELQQQLEVLEQEAWRLRRVNVELQLQGDSAQGEKLEQQEELHLAVRERERLQETLVGLEAKQSESLSELIALREALESSRLAGELLKQEQEEVAAALARAEQSIVELSSSENSLKAEVADLRAAAVKLGALNEALALDKVALNQQLLQLEQENQSMCSRVEAAEQLRSALQVDLAEAERSREALWEEKTHLETQLRKAEETGAELQAELRGAREEKEELKEKLNEAHHQQEAATAQLQQLHQDAERQEEALARAGQEKEALVRERAALEVRLQAVERDRQDLAEQVLGLRSAKEQLEGNLFEAQQQNSVIQVTKSQLEVQIQTIIQAKEVIQGEVKCLKLELDTERSHAEQERDAVARQLAQAEQEGQAALERQKVAHEEEVNRLQEKWEKERALLQQKLDKTLETLERERTELEMKLREQHTETEALRAQREEERTQADSALYQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGMLQAQLRGAQQELKEAIQQHRDDLAAFQKDKIDLQKQVEDLTSQLVTHNDSQRLVKQEIEEKVREAQECSRIQKELEKEKASLTLSLVEKEKRLLVLQEADSVRQRELVSLRQDIQEAQEGQRELGVQVELLRQEVKEKEADFVAREAQLLEELEASRIAERQVRASLWAQEAKAAQLQLQLRSTEAQLEALVAEQQPENQAQAQLRSLYSVLQQALGSACERRPELRGGGDSVPTPWGSDPDQNGASRLLKRGPLLTALSAEAVALALQKLHQDLWKAQQARDDLRDQVQKLVQRLTDTEAQKSQVHSELQDLQRQLSQSQEEKSKWEGKQNSLESELRDLHETMASLQSRLRQAELQKMEAQNDRELLQASKEKLSAQVEHLQACVTEARAQASAAGVLEEDLRTARSALKLKNEEIESERERAQALQEQGELKVAQGKALQENLTLLAQTLSNREREVETLQAEVQELEKQREMQKAALELLSLDLKKRSREVDLQQEQIQELEQCRSVLEHLPMAVQEREQKLSVQRDQIRELENDREAQRTALEHQLLDLEQKAQVIESQRGQIQDLKKQLGTLECLALELEESHRKVEGQQKVITELEGQRELQRVALTHLTLDLEERSQELQTQSSQLHELENHSTRLAKELQERDQEVMSQRQQIEELQKQKEQLTQDLERKGQELVLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERGQELASQWQLMQERAEDGKSPSKAQRGSLEHLKLILRDKEKEVECQQERIQELQEHMGQLEQQLQGLHRKVGETSLLLTHREQETATLQQRLQEAKEQGELREQVLQGQLEEAQRALAQRDHELEALRQEQQQTRGQEESMKQKTSALQAALEQAHVTLKERQGELEEHRGQVQRLQEELIVEGRQVRALEEVLGDLRAESREHEKTVLALQQRCAEQAQEHEAEARTLQDSWLQAQATLAEQEQELEALRAENQYSRQQEEAAFGQAEALQEALSKAQATLQEKEQRLLEQAELSCTLEASTATLQATLDTCQARARQLEEALRVREGEIQTQALQHQEAMQHLQQELCQKEEDLRQQDEQRQLLEKAVAQRSQENGIQEKQSLEQEKEEETRGLLESLKELQLTVAQKEEEILMLREAQQRQNQEASSPSHRSFPAEKPSLQLLLAQQDLERLQNALRQTEAREIEWREKAQGLALSLAQSKASISSLQEIAMFLQASVLERESEQQRLQEELVLSRQALEEQQSRGPHSSSRADQGPKAGQDTEPGEVIEAEPSPGVGEKEQLRQRLERLQQAVAELEVDRSKLQCHNAQLRTTLEQVERERRKLKRDSLRASRAGSLEARETMNSSPTQQDGRGSQRGSSDSMLMVELQREVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETKKLDESLNQSLTSPAPFLHPSLDTTQNTHR", "length": 2428 }, "evidence": [ { "id": "A0AAA9S885", "url": "https://omabrowser.org/oma/group/A0AAA9S885/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q60952-1", "protein_name": "Centrosome-associated protein CEP250", "gene_name": "Cep250", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METGSPGLNMKPQSLQLVLEGQVLALQQQMAENQAASWRKLKNSQEAQKRQATLVRKLQAKVLQYRSWCQDLEKRLEATGGLIPQRWESVEEPNLEQLLIRLEEEQQRCESLVEVNTELRLHMEKADVVNKALQEDVEKLTVDWSRARDELVRKESQWRMEQEFFKGYLRGEHGRLLNLWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQSRESSGSGRTEESEPARLLLLVAKTQALEKEAHEKSQELMQLKSHGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMEILETNHAELMEHEASLSRNAQEEKLSLQQVIKAITQALASVEEEDTVTQSSGHEDSLQSDCNGLSQFDPQDPDRALTLVQSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHDQWEEEGRALREKLQKLTGERDALAGQTVGLQGEVDSLSRERELLQKARGELQQQLEVLEQEAWRLRRMNMELQLQGDSAQGEKLEQQEELHLAVRERERLQETLVGLEAKQSESLSELLTLREALESSRLEGELLKQERVEVAAALARAEQSIVELSGSENSLKAEVADLRAAAVKLGALNEALALDKVELNQQLLQLEQENQSLCSRVEAAEQLRSALQVDLAEAERRREALWEKKTQLETQLQKAEEAGAELQAELRGTREEKEELKDKLSEAHHQQETATAHLEQLHQDAERQEETLARAVQEKEALVRERAALEVRLQAVERDRQDLTEHVLGLRSAKEQLESNLFEAQQQNSVIQVTKGQLEVQIQTIIQAKEVIQGEVKCLKLELDAERTRAEQEWDAVARQLAQAEQEGQASLERQKVAHEEEVNRLQEKWEKERSWLQQELDKTLETLERERAELETKLREQQTEMEAIRAQREEERSQADSALYQMQLETEKERVSLLETLLRTQKELADASQQLERLRQDMKIQKLKEQETTGMLQAQLQETQQELKEAAQQHRDDLAAFQKDKLDLQKQVEDLMSQLVAHDDSQRLVKEEIEEKVKVAQECSRIQKELEKENASLALSLVEKEKRLLILQEADSVRQQELSSLRQDIQEAQEGQRELGVQVELLRQEVKEKEADFVAREAQLLEELEASRVAEQQLRASLWAQEAKATQLQLQLRSTESQLEALVAEQQPENQAQAQLASLCSVLQQALGSACESRPELRGGGDSAPTLWGPDPDQNGASRLFKRWSLPTALSPEAVALALQKLHQDVWKARQARDDLRDQVQKLVQRLTDTEAQKSQVHSELQDLQRQLSQSQEEKSKWEGRQNSLESELRDLHETAASLQSRLRQAELQKMEAQNDRELLQASKEKLSAQVEHLQACVAEAQAQADAAAVLEEDLRTARSALKLKNEELESERERAQALQEQGELKVAQGKALQENLALLAQTLSNREREVETLQAEVQELEKQREMQKAALELLSLDLKKRSREVDLQQEQIQELEQCRSVLEHLPMAVQEREQKLSVQRDQIRELENDREAQRSVLEHQLLDLEQKAQVIESQRGQIQDLKKQLGTLECLALELEESHHKVESQQKMITELEGQREMQRVALTHLTLDLEERSQELQAQSSQLHELENHSTHLAKELQERDQEVTSQRQQIDELQKQQEQLAQALERKGQELVLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERSQELASQWQLVHERADDGKSPSKGQRGSLEHLKLILRDKEKEVECQQERIQELQGHMGQLEQQLQGLHRKVGETSLLLTHREQETATLQQHLQEAKEQGELREQVLQGQLEEAQRDLAQRDHELETLRQEKQQTQDQEESMKLKTSALQAALEQAHATLKERQGELEEHREQVRRLQEELEVEGRQVRALEEVLGDLRAESREHEKAVLALQQRCAEQAQEHEAEARTLQDSWLQAQATLTEQEQELAALRAENQYSRRQEEAAVSQAEALQEALSKAQAALQEKEQSLLEQAELSHTLEASTAALQATLDTCQASARQLEEALRIREGEIQAQALQHHEVTQHLQQELCQKKEELRQLLEKAGARRSQENGIQEKQSLEQERQEETRRLLESLKELQLTVAQREEEILMLREASSPRHRALPAEKPALQPLPAQQELERLQTALRQTEAREIEWREKAQDLALSLAQSKASISSLQEITMFLQASVLERESEQQRLQEELVLSRQALEEQQSGGPHSTSRADQGPKVGQGSQSGEVETEPSPGVEEKERLTQRLERLQQAVAELEVDRSKLQCHNAQLRTALEQVERERRKLKRDSVRASRAGSLEARETMTSSPTQQDGRGSQRGSSDSVLVVELQREVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETRKLDESLNQSLTSPGPCLLHPSLDTTQNTHR", "length": 2414 }, "evidence": [ { "id": "A0AAA9S885", "url": "https://omabrowser.org/oma/group/A0AAA9S885/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BV73-1", "protein_name": "Centrosome-associated protein CEP250", "gene_name": "CEP250", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR", "length": 2442 }, "evidence": [ { "id": "A0AAA9S885", "url": "https://omabrowser.org/oma/group/A0AAA9S885/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of centriole-centriole cohesion", "id": "GO:0030997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030997", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "positive regulation of protein localization to centrosome", "id": "GO:1904781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "detection of light stimulus involved in visual perception", "id": "GO:0050908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050908", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "protein localization to centrosome", "id": "GO:0071539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "centriole-centriole cohesion", "id": "GO:0010457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "spindle pole centrosome", "id": "GO:0031616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9S885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" }, { "id": "PF25774", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25774" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP250 coiled coil", "eco_id": "ECO_0000259", "start_pos": 2099, "end_pos": 2193, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S885" }, { "id": "PF15035", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rootletin-like coiled-coil", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 187, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 2298 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBK8-1", "uniprot_ac": "A0AAA9SBK8", "uniprot_id": "A0AAA9SBK8_BOVIN", "mass": { "chemical_mass": 114712.0, "monoisotopic_mass": 114712.0 }, "refseq": {}, "gene_names": [ { "name": "ULK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9SBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9SBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ULK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8", "locus": { "chromosome": "17", "start_pos": 45177727, "end_pos": 45199589, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012987", "url": "https://www.ensembl.org/id/ENSBTAG00000012987" } ] } } ], "crossref": [ { "id": "A0AAA9SBK8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012987", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012987", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14202", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14202", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526310", "url": "https://www.ncbi.nlm.nih.gov/gene/526310", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NIS1", "url": "https://www.orthodb.org/?gene=A0A3Q1NIS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MFB2", "url": "https://www.orthodb.org/?gene=F1MFB2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24348", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24348", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24348:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24348:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21127", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21127", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5357905", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8934903", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934903", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NIS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFB2", "url": "https://www.uniprot.org/uniprotkb/F1MFB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFB2-1", "url": "https://www.uniprot.org/uniprotkb/F1MFB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPGRGGLEAVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQGVLPTTSHCLFCVLQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASATVKKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQELQKTLTSPAEAAGFLHGSRDSGGSSKDSSCDTDDFVMVPAQFPGDLVAEAAGAKPPPDSLMCSGSSLAASTGLDSRGRTPSPSPPCGSSLSPSGRTGTFSSSRCGASVPIPVPTQVQNYQRIEQNLQSPTQYQTARSSAIRRSGSTSPLGFARASPSPPSHAEHGAALARKLSLGGGRPYTPSPQVGTIPERPGWSGAPSPQASEMRGGRSPRPGSSAPEHSPHTSGLGYRLHSAPNLSDLHVVRPKLPKPPTDPLGVAFGHPQASPPQPSHGLQSCRPLRGSPKLPDFLQRNPLPPILGSPTKTVPVFEFTKTPSSQNLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGPGLRPTEDTKGAFGRSLSTGRLTDLLLKAAFGTQAPDSGSTDSLQEKPMEIAPSAGFGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGPRTTMFSVGSSSSLSSAGSSSARHLAPGAYSEATLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLMEQEHTEILHSLRFTLVFVQHILEIAALKGSASEAAGGPEDQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRKLNELYKTSVVSCQSLSLRLQRFFLDKQRLLDRIQSVTAEKLIFSHAVQTVQSAALDEMFHRREDCVQRYHKALLLMEGLQQILTDQADVENIAKCKLCIERRLSALLTGICA", "length": 1070, "header": "tr|A0AAA9SBK8-1|A0AAA9SBK8_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=ULK1 PE=4 SV=1 CANONICAL=A0AAA9SBK8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NIS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8/entry#A0A3Q1NIS1-1", "sequence": { "sequence": "MKTSWLCTTFRRAPTFPGTPIATGTSTFPRREVWLLCGPPEVSDPVVPKEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASATVKKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQELQKTLTSPAEAAGFLHGSRDSGGSSKDSSCDTDDFVMVPAQFPGDLVAEAAGAKPPPDSLMCSGSSLAASTGLDSRGRTPSPSPPCGSSLSPSGRTGTFSSSRCGASVPIPVPTQVQNYQRIEQNLQSPTQYQTARSSAIRRSGSTSPLGFARASPSPPSHAEHGAALARKLSLGGGRPYTPSPQVGTIPERPGWSGAPSPQASEMRGGRSPRPGSSAPEHSPHTSGLGYRLHSAPNLSDLHVVRPKLPKPPTDPLGVAFGHPQASPPQPSHGLQSCRPLRGSPKLPDFLQRNPLPPILGSPTKTVPVFEFTKTPSSQNLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGPGLRPTEDTKGAFGRSLSTGRLTDLLLKAAFGTQAPDSGSTDSLQEKPMEIAPSAGFGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGPRTTMFSVGSSSSLSSAGSSSARHLAPGAYSEATLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLMEQEHTEILHSLRFTLVFVQHILEIAALKGSASEAAGGPEDQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRKLNELYKTSVVSCQSLSLRLQRFFLDKQRLLDRIQSVTAEKLIFSHAVQTVQSAALDEMFHRREDCVQRYHKALLLMEGLQQILTDQADVENIAKCKLCIERRLSALLTGICA", "length": 1022, "header": "tr|A0A3Q1NIS1-1|A0AAA9SBK8_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=ULK1 PE=4 SV=2 CANONICAL=A0AAA9SBK8-1" }, "locus": { "chromosome": "17", "start_pos": 45198800, "end_pos": 45178372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085931.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085931.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071958.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071958.2" } ] } }, { "isoform_ac": "A0AAA9SBK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8/entry#A0AAA9SBK8-1", "sequence": { "sequence": "MEPGRGGLEAVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQGVLPTTSHCLFCVLQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASATVKKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQELQKTLTSPAEAAGFLHGSRDSGGSSKDSSCDTDDFVMVPAQFPGDLVAEAAGAKPPPDSLMCSGSSLAASTGLDSRGRTPSPSPPCGSSLSPSGRTGTFSSSRCGASVPIPVPTQVQNYQRIEQNLQSPTQYQTARSSAIRRSGSTSPLGFARASPSPPSHAEHGAALARKLSLGGGRPYTPSPQVGTIPERPGWSGAPSPQASEMRGGRSPRPGSSAPEHSPHTSGLGYRLHSAPNLSDLHVVRPKLPKPPTDPLGVAFGHPQASPPQPSHGLQSCRPLRGSPKLPDFLQRNPLPPILGSPTKTVPVFEFTKTPSSQNLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGPGLRPTEDTKGAFGRSLSTGRLTDLLLKAAFGTQAPDSGSTDSLQEKPMEIAPSAGFGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGPRTTMFSVGSSSSLSSAGSSSARHLAPGAYSEATLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLMEQEHTEILHSLRFTLVFVQHILEIAALKGSASEAAGGPEDQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRKLNELYKTSVVSCQSLSLRLQRFFLDKQRLLDRIQSVTAEKLIFSHAVQTVQSAALDEMFHRREDCVQRYHKALLLMEGLQQILTDQADVENIAKCKLCIERRLSALLTGICA", "length": 1070, "header": "tr|A0AAA9SBK8-1|A0AAA9SBK8_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=ULK1 PE=4 SV=1 CANONICAL=A0AAA9SBK8-1" }, "locus": { "chromosome": "17", "start_pos": 45199433, "end_pos": 45178372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092460.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092460.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080858.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080858.1" } ] } }, { "isoform_ac": "A0AAA9TGF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8/entry#A0AAA9TGF9-1", "sequence": { "sequence": "MCWMGVGGLMGPWRPHPQSSSCVWASSGHVRRAPTFPGTPIATGTSTFPRREVWLLCGPPEVSDPVVPKEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASATVKKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQELQKTLTSPAEAAGFLHGSRDSGGSSKDSSCDTDDFVMVPAQFPGDLVAEAAGAKPPPDSLMCSGSSLAASTGLDSRGRTPSPSPPCGSSLSPSGRTGTFSSSRCGASVPIPVPTQVQNYQRIEQNLQSPTQYQTARSSAIRRSGSTSPLGFARASPSPPSHAEHGAALARKLSLGGGRPYTPSPQVGTIPERPGWSGAPSPQASEMRGGRSPRPGSSAPEHSPHTSGLGYRLHSAPNLSDLHVVRPKLPKPPTDPLGVAFGHPQASPPQPSHGLQSCRPLRGSPKLPDFLQRNPLPPILGSPTKTVPVFEFTKTPSSQNLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGPGLRPTEDTKGAFGRSLSTGRLTDLLLKAAFGTQAPDSGSTDSLQEKPMEIAPSAGFGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGPRTTMFSVGSSSSLSSAGSSSARHLAPGAYSEATLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLMEQEHTEILHSLRFTLVFVQHILEIAALKGSASEAAGGPEDQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRKLNELYKTSVVSCQSLSLRLQRFFLDKQRLLDRIQSVTAEKLIFSHAVQTVQSAALDEMFHRREDCVQRYHKALLLMEGLQQILTDQADVENIAKCKLCIERRLSALLTGICA", "length": 1042, "header": "tr|A0AAA9TGF9-1|A0AAA9TGF9_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=ULK1 PE=4 SV=1 CANONICAL=A0AAA9SBK8-1" }, "locus": { "chromosome": "17", "start_pos": 45198590, "end_pos": 45178372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102904.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102904.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095257.1" } ] } }, { "isoform_ac": "F1MFB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8/entry#F1MFB2-1", "sequence": { "sequence": "MEPGRGGLEAVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASATVKKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQELQKTLTSPAEAAGFLHGSRDSGGSSKDSSCDTDDFVMVPAQFPGDLVAEAAGAKPPPDSLMCSGSSLAASTGLDSRGRTPSPSPPCGSSLSPSGRTGTFSSSRCGASVPIPVPTQVQNYQRIEQNLQSPTQYQTARSSAIRRSGSTSPLGFARASPSPPSHAEHGAALARKLSLGGGRPYTPSPQVGTIPERPGWSGAPSPQASEMRGGRSPRPGSSAPEHSPHTSGLGYRLHSAPNLSDLHVVRPKLPKPPTDPLGVAFGHPQASPPQPSHGLQSCRPLRGSPKLPDFLQRNPLPPILGSPTKTVPVFEFTKTPSSQNLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGPGLRPTEDTKGAFGRSLSTGRLTDLLLKAAFGTQAPDSGSTDSLQEKPMEIAPSAGFGGNLHPGARAGGASSPSPVVFTVGSPPSGTTPPQGPRTTMFSVGSSSSLSSAGSSSARHLAPGAYSEATLEVPAPGHCCSFADPVTANLEGAVTFEAPDLPEETLMEQEHTEILHSLRFTLVFVQHILEIAALKGSASEAAGGPEDQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRKLNELYKTSVVSCQSLSLRLQRFFLDKQRLLDRIQSVTAEKLIFSHAVQTENRGPRFQVSLQVQSAALDEMFHRREDCVQRYHKALLLMEGLQQILTDQADVENIAKCKLCIERRLSALLTGICA", "length": 1067, "header": "tr|F1MFB2-1|F1MFB2_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=ULK1 PE=4 SV=4 CANONICAL=A0AAA9SBK8-1" }, "locus": { "chromosome": "17", "start_pos": 45199433, "end_pos": 45178372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017268.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017268.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017268.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017268.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-5357905", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "resource": "Reactome", "description": "Regulation of TNFR1 signaling" }, { "id": "R-BTA-8854214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "resource": "Reactome", "description": "TBC/RABGAPs" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" }, { "id": "R-BTA-8934903", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934903", "resource": "Reactome", "description": "Receptor Mediated Mitophagy" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "regulation of macroautophagy", "id": "GO:0016241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016241", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "negative regulation of protein-containing complex assembly", "id": "GO:0031333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "cellular response to stress", "id": "GO:0033554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033554", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "negative regulation of collateral sprouting", "id": "GO:0048671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048671", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "Atg1/ULK1 kinase complex", "id": "GO:1990316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990316", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "omegasome membrane", "id": "GO:1903349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903349", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" }, { "name": "phagophore assembly site", "id": "GO:0000407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000407", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 675, "end_pos": 677, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "F1MTL5-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-1632857", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632857" } ] }, { "id": "R-BTA-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5665868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5665868" } ] }, { "id": "R-BTA-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5672008", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672008" } ] }, { "id": "R-BTA-5672010", "name": "Active MTORC1 phosphorylates ULK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SX43-1", "A0AAA9SBK8-1", "A0A3Q1MEZ6-1" ], "evidence": [ { "id": "R-BTA-5672010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672010" } ] }, { "id": "R-BTA-5672011", "name": "p-AMPK:AMP binds the ULK complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5672011", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672011" } ] }, { "id": "R-BTA-5672817", "name": "Active MTORC1 binds the ULK1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SX43-1", "A0AAA9SBK8-1", "A0A3Q1MEZ6-1" ], "evidence": [ { "id": "R-BTA-5672817", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672817" } ] }, { "id": "R-BTA-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SX43-1", "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "A0A3Q1MEZ6-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5673768", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673768" } ] }, { "id": "R-BTA-5675790", "name": "MTORC1 dissociates from ULK complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SX43-1", "A0AAA9SBK8-1", "A0A3Q1MEZ6-1" ], "evidence": [ { "id": "R-BTA-5675790", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675790" } ] }, { "id": "R-BTA-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5675868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675868" } ] }, { "id": "R-BTA-5679205", "name": "ULK1 phosphorylates Beclin-1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "F1MTL5-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5679205", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5679205" } ] }, { "id": "R-BTA-5679239", "name": "ULK complex translocates to the ER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5679239", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5679239" } ] }, { "id": "R-BTA-5683925", "name": "ULK1 is dephosphorylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1" ], "evidence": [ { "id": "R-BTA-5683925", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683925" } ] }, { "id": "R-BTA-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "recycling endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHP2-1", "A0AAA9SBK8-1", "F2Z4D5-1" ], "evidence": [ { "id": "R-BTA-8854759", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854759" } ] }, { "id": "R-BTA-8876446", "name": "p-ULK1 phosphorylates DENND3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-8876435" ], "output_participant_list": [ "R-BTA-8876434" ], "enzyme_list": [ "A0AAA9SBK8-1" ], "evidence": [ { "id": "R-BTA-8876446", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876446" } ] }, { "id": "R-BTA-8948136", "name": "ULK1 Translocates to the mitochondria", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial outer membrane", "input_participant_list": [ "R-BTA-1632847" ], "output_participant_list": [ "R-BTA-8948145" ], "enzyme_list": [ "A0AAA9SBK8-1" ], "evidence": [ { "id": "R-BTA-8948136", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948136" } ] }, { "id": "R-BTA-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial outer membrane", "input_participant_list": [ "R-BTA-8934922" ], "output_participant_list": [ "R-BTA-8948140" ], "enzyme_list": [ "A0AAA9SBK8-1" ], "evidence": [ { "id": "R-BTA-8948146", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948146" } ] }, { "id": "R-BTA-9819106", "name": "ULK1 phosphorylates RIPK1 at S357", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "E1B9D9-1" ], "evidence": [ { "id": "R-BTA-9819106", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9819106" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-1632847", "participant_name": "ULK1 [cytosol]", "crossref": [ { "id": "F1MFB2", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000012987", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000017268", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000017268", "database": "ENSEMBL", "url": "" }, { "id": "XP_010812127.1", "database": "RefSeq", "url": "" }, { "id": "36658", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8876434", "participant_name": "phospho-DENND3 [cytosol]", "crossref": [ { "id": "A0A3Q1MCL3", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000066520", "database": "ENSEMBL", "url": "" }, { "id": "27998", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000087265", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000006132", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-8876435", "participant_name": "DENND3 [cytosol]", "crossref": [ { "id": "A0A3Q1MCL3", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006132", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000066520", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000087265", "database": "ENSEMBL", "url": "" }, { "id": "27998", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8934922", "participant_name": "FUNDC1 [mitochondrial outer membrane]", "crossref": [ { "id": "F1N5S9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000001637", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000002144", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000002144", "database": "ENSEMBL", "url": "" }, { "id": "NP_001098452.1", "database": "RefSeq", "url": "" }, { "id": "29143", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8948140", "participant_name": "phospho-FUNDC1 [mitochondrial outer membrane]", "crossref": [ { "id": "ENSBTAP00000002144", "database": "ENSEMBL", "url": "" }, { "id": "F1N5S9", "database": "UniProt", "url": "" }, { "id": "NP_001098452.1", "database": "RefSeq", "url": "" }, { "id": "29143", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000002144", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000001637", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-8948145", "participant_name": "ULK1 [mitochondrial outer membrane]", "crossref": [ { "id": "XP_010812127.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000017268", "database": "ENSEMBL", "url": "" }, { "id": "F1MFB2", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000012987", "database": "ENSEMBL", "url": "" }, { "id": "36658", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000017268", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0AAA9SBK8", "gene_name": "ULK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "E1B9D9", "gene_name": "TRAF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B9D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B9D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D9" } ] } ] }, { "uniprot_ac": "F1MTL5", "gene_name": "PIK3C3", "activity": [ { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "F1MTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "F1MTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK8" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 293, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 576, "end_pos": 578 }, { "start_pos": 675, "end_pos": 677 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCB7-1", "uniprot_ac": "A0AAA9SCB7", "uniprot_id": "A0AAA9SCB7_BOVIN", "mass": { "chemical_mass": 74855.0, "monoisotopic_mass": 74855.0 }, "refseq": {}, "gene_names": [ { "name": "LEO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ] } ], "protein_names": [ { "name": "RNA polymerase-associated protein LEO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LEO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7", "locus": { "chromosome": "10", "start_pos": 58440881, "end_pos": 58403720, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013830", "url": "https://www.ensembl.org/id/ENSBTAG00000013830" } ] } } ], "crossref": [ { "id": "A0AAA9SCB7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCB7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013830", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013830", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507524", "url": "https://www.ncbi.nlm.nih.gov/gene/507524", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJ29", "url": "https://www.orthodb.org/?gene=A0A3Q1NJ29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23146:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23146:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LW51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJ29", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJ29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGNYVFRNMDSDSGSGSDSDQENVASGSNASGSESDQDERDDAGKPSNKELFGDDSEDEGASHHSGSDNHSEGSDNRSEASEHSDHEDNDPSDVDQHSGSETRNDNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSEDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEERPQISDEEKMQNSDDERPQPSDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAESDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDRAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD", "length": 659, "header": "tr|A0AAA9SCB7-1|A0AAA9SCB7_BOVIN Isoform 1 of RNA polymerase-associated protein LEO1 OS=Bos taurus OX=9913 GN=LEO1 PE=3 SV=1 CANONICAL=A0AAA9SCB7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7/entry#A0A3Q1LW51-1", "sequence": { "sequence": "MADMEDLFGSDADSDPERKDSDSGSGSDSDQENVASGSNASGSESDQDERDDAGKPSNKELFGDDSEDEGASHHSGSDNHSEGSDNRSEASEHSDHEDNDPSDVDQHSGSETRNDNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSEDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEERPQISDEEKMQNSDDERPQPSDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAESDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIRGG", "length": 603, "header": "tr|A0A3Q1LW51-1|A0A3Q1LW51_BOVIN Computationally mapped isoform of RNA polymerase-associated protein LEO1 OS=Bos taurus OX=9913 GN=LEO1 PE=3 SV=3 CANONICAL=A0AAA9SCB7-1" }, "locus": { "chromosome": "10", "start_pos": 58439981, "end_pos": 58404152, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075873.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075873.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061429.3", "url": "https://www.ensembl.org/id/ENSBTAP00000061429.3" } ] } }, { "isoform_ac": "A0A3Q1NJ29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7/entry#A0A3Q1NJ29-1", "sequence": { "sequence": "MADMEDLFGSDADSDPERKDSDSGSGSDSDQENVASGSNASGSESDQDERDDAGKPSNKELFGDDSEDEGASHHSGSDNHSEGSDNRSEASEHSDHEDNDPSDVDQHSGSETRNDNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSEDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEERPQISDEEKMQNSDDERPQPSDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAESDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDRAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD", "length": 608, "header": "tr|A0A3Q1NJ29-1|A0AAA9SCB7_BOVIN Computationally mapped isoform of RNA polymerase-associated protein LEO1 OS=Bos taurus OX=9913 GN=LEO1 PE=3 SV=2 CANONICAL=A0AAA9SCB7-1" }, "locus": { "chromosome": "10", "start_pos": 58440078, "end_pos": 58404152, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069682.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069682.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072092.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072092.2" } ] } }, { "isoform_ac": "A0AAA9SCB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7/entry#A0AAA9SCB7-1", "sequence": { "sequence": "MNGNYVFRNMDSDSGSGSDSDQENVASGSNASGSESDQDERDDAGKPSNKELFGDDSEDEGASHHSGSDNHSEGSDNRSEASEHSDHEDNDPSDVDQHSGSETRNDNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSEDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEERPQISDEEKMQNSDDERPQPSDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAESDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDRAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD", "length": 659, "header": "tr|A0AAA9SCB7-1|A0AAA9SCB7_BOVIN Isoform 1 of RNA polymerase-associated protein LEO1 OS=Bos taurus OX=9913 GN=LEO1 PE=3 SV=1 CANONICAL=A0AAA9SCB7-1" }, "locus": { "chromosome": "10", "start_pos": 58440078, "end_pos": 58404553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132132.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132132.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083769.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083769.1" } ] } }, { "isoform_ac": "A0AAA9SIF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7/entry#A0AAA9SIF2-1", "sequence": { "sequence": "MYPDSDSGSGSDSDQENVASGSNASGSESDQDERDDAGKPSNKELFGDDSEDEGASHHSGSDNHSEGSDNRSEASEHSDHEDNDPSDVDQHSGSETRNDNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSEDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEERPQISDEEKMQNSDDERPQPSDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEAESDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDRAQRLLKAKKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD", "length": 652, "header": "tr|A0AAA9SIF2-1|A0AAA9SIF2_BOVIN Computationally mapped isoform of RNA polymerase-associated protein LEO1 OS=Bos taurus OX=9913 GN=LEO1 PE=3 SV=1 CANONICAL=A0AAA9SCB7-1" }, "locus": { "chromosome": "10", "start_pos": 58440078, "end_pos": 58403919, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108315.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108315.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083695.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 326, "start_aa": "Thr", "end_pos": 326, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr326", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "transcription elongation by RNA polymerase II", "id": "GO:0006368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006368", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" }, { "name": "stem cell population maintenance", "id": "GO:0019827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" }, { "name": "endodermal cell fate commitment", "id": "GO:0001711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001711", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" }, { "name": "negative regulation of myeloid cell differentiation", "id": "GO:0045638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045638", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" }, { "name": "mRNA 3'-end processing", "id": "GO:0031124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Cdc73/Paf1 complex", "id": "GO:0016593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 326 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 30, "end_pos": 32 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAY2-1", "uniprot_ac": "A0AAA9SAY2", "uniprot_id": "A0AAA9SAY2_BOVIN", "mass": { "chemical_mass": 57740.0, "monoisotopic_mass": 57740.0 }, "refseq": {}, "gene_names": [ { "name": "TRIT1", "type": "recommended", "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ] } ], "protein_names": [ { "name": "tRNA dimethylallyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.75", "type": "synonym", "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#names_and_taxonomy" } ] }, { "name": "Isopentenyl-diphosphate:tRNA isopentenyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA). TRIT1 is therefore required for selenoprotein expression.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW8#function" }, { "database": "UniProtKB", "id": "ARBA00057810", "url": "https://www.uniprot.org/uniprotkb/ARBA00057810#function" }, { "database": "UniProtKB", "id": "A0AAA9RZZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZZ8#function" }, { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2", "locus": { "chromosome": "3", "start_pos": 106249621, "end_pos": 106204771, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013832", "url": "https://www.ensembl.org/id/ENSBTAG00000013832" } ] } } ], "crossref": [ { "id": "A0AAA9SAY2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR018022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11088", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11088", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11088:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11088:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01715", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01715", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "26482", "url": "https://www.rhea-db.org/rhea/26482", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAAARAVSVGPGLQSLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQRLCQHHMISFVDPLVMNYTVVDFRNKATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNAKPQEMGTEKVIDRKVELEKEDGHVLHKRLSQVDPEMAAKLHPHDKRKVARKVKSESEVAQSCPTLSNPMDCSPSGSSAHGIFQARVLEWGAIAFSDSRSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHAEQTVLDERLDKRVDNMLAAGLLDELRDFHKRYNEKKVAENSQDYQHGIFQSIGFKEFHEYLITEGKCTPEIRNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGTSVPPVYGLEVSDVSKWEESVLEPALEIVRSFIQGHKPAATPVKMPGSETENKRSYHMCELCDRIIIGDREWAAHMKSKSHLHQLKKRRRLDSDAVTTVESQSVSPDHDKELKEKESLGQNDKELKASI", "length": 515, "header": "tr|A0AAA9SAY2-1|A0AAA9SAY2_BOVIN Isoform 1 of tRNA dimethylallyltransferase OS=Bos taurus OX=9913 GN=TRIT1 PE=3 SV=1 CANONICAL=A0AAA9SAY2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#A0AAA9RZZ8-1", "sequence": { "sequence": "MAAAAAARAVSVGPGLQSLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQPQEMGTEKVIDRKVELEKEDGHVLHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHAEQTDERLDKRVDNMLAAGLLDELRDFHKRYNEKKVAENSQDYQHGIFQSIGFKEFHEYLITEGKCTPEIRNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGTSVPPVYGLEVSDVSKWEESVLEPALEIVRSFIQGHKPAATPVKMPGSETENKRSYHMCELCDRIIIGDREWAAHMKSKSHLHQLKKRRRLDSDAVTTVESQSVSPDHDKELKEKESLGQNDKELKASI", "length": 385, "header": "tr|A0AAA9RZZ8-1|A0AAA9SAY2_BOVIN Computationally mapped isoform of tRNA dimethylallyltransferase OS=Bos taurus OX=9913 GN=TRIT1 PE=3 SV=1 CANONICAL=A0AAA9SAY2-1" }, "locus": { "chromosome": "3", "start_pos": 106248220, "end_pos": 106204847, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120021.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120021.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079176.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079176.1" } ] } }, { "isoform_ac": "A0AAA9SAW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#A0AAA9SAW8-1", "sequence": { "sequence": "MAAAAAARAVSVGPGLQSLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQRLCQHHMISFVDPLVMNYTVVDFRNKATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNAKPQEMGTEKVIDRKVELEKEDGHVLHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHAEQTVLDERLDKRVDNMLAAGLLDELRDFHKRYNEKKVAENSQDYQHGIFQSIGFKEFHEYLITEGKCTPEIRNQLLKKGPGTSVPPVYGLEVSDVSKWEESVLEPALEIVRSFIQGHKPAATPVKMPGSETENKRSYHMCELCDRIIIGDREWAAHMKSKSHLHQLKKRRRLDSDAVTTVESQSVSPDHDKELKEKESLGQNDKELKASI", "length": 441, "header": "tr|A0AAA9SAW8-1|A0AAA9SAY2_BOVIN Computationally mapped isoform of tRNA dimethylallyltransferase OS=Bos taurus OX=9913 GN=TRIT1 PE=3 SV=2 CANONICAL=A0AAA9SAY2-1" }, "locus": { "chromosome": "3", "start_pos": 106248220, "end_pos": 106204847, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099515.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099515.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082491.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082491.2" } ] } }, { "isoform_ac": "A0AAA9SAY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#A0AAA9SAY2-1", "sequence": { "sequence": "MAAAAAARAVSVGPGLQSLQRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQRLCQHHMISFVDPLVMNYTVVDFRNKATALIEDIFARDKIPIVVGGTNYYIESLLWKVLVNAKPQEMGTEKVIDRKVELEKEDGHVLHKRLSQVDPEMAAKLHPHDKRKVARKVKSESEVAQSCPTLSNPMDCSPSGSSAHGIFQARVLEWGAIAFSDSRSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHAEQTVLDERLDKRVDNMLAAGLLDELRDFHKRYNEKKVAENSQDYQHGIFQSIGFKEFHEYLITEGKCTPEIRNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGTSVPPVYGLEVSDVSKWEESVLEPALEIVRSFIQGHKPAATPVKMPGSETENKRSYHMCELCDRIIIGDREWAAHMKSKSHLHQLKKRRRLDSDAVTTVESQSVSPDHDKELKEKESLGQNDKELKASI", "length": 515, "header": "tr|A0AAA9SAY2-1|A0AAA9SAY2_BOVIN Isoform 1 of tRNA dimethylallyltransferase OS=Bos taurus OX=9913 GN=TRIT1 PE=3 SV=1 CANONICAL=A0AAA9SAY2-1" }, "locus": { "chromosome": "3", "start_pos": 106248220, "end_pos": 106204847, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119486.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119486.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082510.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082510.1" } ] } }, { "isoform_ac": "A0AAA9T5C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2/entry#A0AAA9T5C2-1", "sequence": { "sequence": "KLQKIGIEALKQVTKRYARKQNRWVKNRFLSRPGTSVPPVYGLEVSDVSKWEESVLEPALEIVRSFIQGHKPAATPVKMPGSETENKRSYHMCELCDRIIIGDREWAAHMKSKSHLHQLKKRRRLDSDAVTTVESQSVSPDHDKELKEKESLGQNDKELKASI", "length": 163, "header": "tr|A0AAA9T5C2-1|A0AAA9T5C2_BOVIN Computationally mapped isoform of tRNA isopentenyltransferase 1 OS=Bos taurus OX=9913 GN=TRIT1 PE=4 SV=1 CANONICAL=A0AAA9SAY2-1" }, "locus": { "chromosome": "3", "start_pos": 106248220, "end_pos": 106242001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112147.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112147.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093023.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" }, { "name": "tRNA dimethylallyltransferase activity", "id": "GO:0052381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052381", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" }, { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" }, { "name": "mitochondrial tRNA modification", "id": "GO:0070900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "26482", "name": "", "equation": "adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SAY2-1" ], "evidence": [ { "id": "26482", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26482" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SAY2", "gene_name": "TRIT1", "activity": [ { "ec_number": "2.5.1.75", "activity": "adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate.", "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ] }, { "ec_number": "2.5.1.75", "activity": "", "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY2" }, { "id": "PF12171", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Zinc finger double-stranded RNA binding", "eco_id": "ECO_0000259", "start_pos": 443, "end_pos": 467, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.75", "ec_name": "adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate.", "evidence": [ { "id": "2.5.1.75", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.75" }, { "id": "2.5.1.75", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.75" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE70-1", "uniprot_ac": "A0AAA9SE70", "uniprot_id": "A0AAA9SE70_BOVIN", "mass": { "chemical_mass": 33230.0, "monoisotopic_mass": 33230.0 }, "refseq": {}, "gene_names": [ { "name": "HOXB6", "type": "recommended", "evidence": [ { "id": "A0AAA9SE70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" } ] } ], "protein_names": [ { "name": "Homeobox B6", "type": "synonym", "evidence": [ { "id": "A0AAA9SE70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70#function" }, { "database": "UniProtKB", "id": "ARBA00003263", "url": "https://www.uniprot.org/uniprotkb/ARBA00003263#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOXB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70", "locus": { "chromosome": "19", "start_pos": 37897080, "end_pos": 37887739, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050006", "url": "https://www.ensembl.org/id/ENSBTAG00000050006" } ] } } ], "crossref": [ { "id": "A0AAA9SE70", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE70", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017995", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017995", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45659", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45659", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45659:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45659:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SSWRVNGQSAQDCSLIPFFKARTYSIFYANIRKAKHPLSQVREGEATALRLGQYYLEDEEETERSSPPPFLPPLSIGGKKPQGLQSGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFAASSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEPPPFHPEPRKSDCAQDKSVFGEAEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKPAE", "length": 294, "header": "tr|A0AAA9SE70-1|A0AAA9SE70_BOVIN Isoform 1 of Homeobox B6 OS=Bos taurus OX=9913 GN=HOXB6 PE=3 SV=1 CANONICAL=A0AAA9SE70-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70/entry#A0AAA9SE70-1", "sequence": { "sequence": "SSWRVNGQSAQDCSLIPFFKARTYSIFYANIRKAKHPLSQVREGEATALRLGQYYLEDEEETERSSPPPFLPPLSIGGKKPQGLQSGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFAASSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEPPPFHPEPRKSDCAQDKSVFGEAEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKPAE", "length": 294, "header": "tr|A0AAA9SE70-1|A0AAA9SE70_BOVIN Isoform 1 of Homeobox B6 OS=Bos taurus OX=9913 GN=HOXB6 PE=3 SV=1 CANONICAL=A0AAA9SE70-1" }, "locus": { "chromosome": "19", "start_pos": 37896076, "end_pos": 37887938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091902.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091902.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080685.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SE70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE70" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 274, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC39-1", "uniprot_ac": "A0AAA9SC39", "uniprot_id": "A0AAA9SC39_BOVIN", "mass": { "chemical_mass": 96953.0, "monoisotopic_mass": 96953.0 }, "refseq": { "ac": "XP_010820510", "name": "Fanconi anemia group B protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820510" }, "gene_names": [ { "name": "FANCB", "type": "recommended", "evidence": [ { "id": "A0AAA9SC39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ] }, { "name": "FANCB", "type": "synonym", "evidence": [ { "id": "XP_010820510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820510" } ] } ], "protein_names": [ { "name": "FA complementation group B", "type": "synonym", "evidence": [ { "id": "A0AAA9SC39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39/entry#names_and_taxonomy" } ] }, { "name": "Fanconi anemia group B protein", "type": "synonym", "evidence": [ { "id": "XP_010820510", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820510" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FANCB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39", "locus": { "chromosome": "X", "start_pos": 128689391, "end_pos": 128628255, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016433", "url": "https://www.ensembl.org/id/ENSBTAG00000016433" } ] } } ], "crossref": [ { "id": "A0AAA9SC39", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016433", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016433", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616549", "url": "https://www.ncbi.nlm.nih.gov/gene/616549", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616549", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616549", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LAFHRVC", "url": "https://omabrowser.org/oma/group/LAFHRVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3X787", "url": "https://www.orthodb.org/?gene=G3X787", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28450:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28450:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28312", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28312", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010820510", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820510", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X787", "url": "https://www.uniprot.org/uniprotkb/G3X787", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X787-1", "url": "https://www.uniprot.org/uniprotkb/G3X787-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSTEQERFCCYNGEVLIFHLSEGNFVDEGPKKTPVLHVRRMVFGRGPEGFVQKSTGFFSIKEEYSHLKIMCCDCVSDFRTGINLPYVMIQCIKEENIFKYFLLFLHGTNKFEKCLSFRLGYELKDSIRVLNGPLVLWRHGQTFFYISSQTGKVVTVPMNFSSVEWAGEIENLGMVLLGPKRCYLSAEGCTPKPSKSDYATWNTHFCAYSLERAEIISDTYIIPPAYTSMITFVHVYSTEIVNDQLRMSLIALTQKNQLISFLNGTPTSVCQLPFGDPCAVQLVDSGEEELLFIISFKSSHACAVWEKSFQVAAKWEKIRSVLIDDFFGTGTEQVLLLFKDSWNSDCRSSFEIMGHDAFNCSGETLDCNEDDLFDDKHGNCYLVVLPLERRLKVGFISIWELQQHLLLKEKIISKSYKALMNLFQRKDDSTLSAEEECLVTLCGEEENPVCTFNEKLSDNFQDLEQLVEKIWYRVIEDSLVIGVKATSSWKVSLNHVTLLLSVDQGSNSTFPLIKCQNKIFKLTRNSSPVLSSVPYEVGSEVKRIKLSVDSKEEKEESVVCEQPLKKEYVQMITAVTALPPLLTFSNFCCIVLLQMRENGNSSEAHYVQCGRIVLSVEDLSSGKCVLTFPERKPIEHMEDLFTLLAAWHRACFQITSPMFALTSVRVWLLEHMKCEVLKEFPEIWFCKRPGSFYGTLFNWKQRTPFEGILVVYSRNQTVLFQCLHDLSTVLPINSFFKYLELESEDFLIGHLAVALEKELVTLGSPPSALVKVETSLVQNCEVSKEKSSDDGAALSDIEKSIHLYRKELQREKEQMLGTNLKVSGALYREMTLKLAEVQLNSDLAAKQLTDL", "length": 852, "header": "tr|A0AAA9SC39-1|A0AAA9SC39_BOVIN Isoform 1 of FA complementation group B OS=Bos taurus OX=9913 GN=FANCB PE=4 SV=1 CANONICAL=A0AAA9SC39-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39/entry#A0A3Q1LLT4-1", "sequence": { "sequence": "MSSTEQERFCCYNGEVLIFHLSEGNFVDEGPKKTPVLHVRRMVFGRGPEGFVQKSTGFFSIKEEYSHLKIMCCDCVSDFRTGINLPYVMIQCIKEENIFKYFLLFLHGTNKFEKCLSFRLGYELKDSIRVLNGPLVLWRHGQTFFYISSQTGKVVTVPMNFSSVEWAGEIENLGMVLLGPKRCYLSAEGCTPKPSKSDYATWNTHFCAYSLERAEIISDTYIIPPAYTSMITFVHVYSTEIVNDQLRMSLIALTQKNQLISFLNGTPTSVCQLPFGDPCAVQLVDSGEEELLFIISFKSSHACAVWEKSFQVAAKWEKIRSVLIDDFFGTGTEQVLLLFKDSWNSDCRSSFEIMGHDAFNCSGETLDCNEDDLFDDKHGNCYLVVLPLERRLKVGFISIWELQQHLLLKEKIISKSYKALMNLFQRKDDSTLSAEEECLVTLCGEEENPVCTFNEKLSDNFQDLEQLVEKIWYRVIEDSLVIGVKATSSWKVSLNHVTLLLSVDQGSNSTFPLIKCQNKIFKLTRNSSPVLSSVPYEVGSEVKRIKLSVDSKEEKEESVVCEQPLKKEYVQMITAVTALPPLLTFSNFCCIVLLQMRENGNSSEAHYVQCGRIVLSVEDLSSGKCVLTFPERKPIEHMEDLFTLLAAWHRACFQITSPMFALTSVRVWLLEHMKCEVLKEFPEIWFCKRPGSFYGTLFNWKQRTPFEGILVVYSRNQTVLFQCLHDLSTVLPINSFFKYLELESEDFLIGHLAVALEKELVTLGSPPSALVKVETSLVQNCEVSKEKSSDDGAALSDIEKSIHLYRKELQREKEQMLGTNLKDSSTARNDPAQILGWDPSHADHCEEGE", "length": 849, "header": "tr|A0A3Q1LLT4-1|A0AAA9SC39_BOVIN Computationally mapped isoform of FA complementation group B OS=Bos taurus OX=9913 GN=FANCB PE=4 SV=1 CANONICAL=A0AAA9SC39-1" }, "locus": { "chromosome": "X", "start_pos": 128689188, "end_pos": 128644820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082853.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082853.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057749.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057749.2" } ] } }, { "isoform_ac": "A0AAA9SC39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39/entry#A0AAA9SC39-1", "sequence": { "sequence": "MSSTEQERFCCYNGEVLIFHLSEGNFVDEGPKKTPVLHVRRMVFGRGPEGFVQKSTGFFSIKEEYSHLKIMCCDCVSDFRTGINLPYVMIQCIKEENIFKYFLLFLHGTNKFEKCLSFRLGYELKDSIRVLNGPLVLWRHGQTFFYISSQTGKVVTVPMNFSSVEWAGEIENLGMVLLGPKRCYLSAEGCTPKPSKSDYATWNTHFCAYSLERAEIISDTYIIPPAYTSMITFVHVYSTEIVNDQLRMSLIALTQKNQLISFLNGTPTSVCQLPFGDPCAVQLVDSGEEELLFIISFKSSHACAVWEKSFQVAAKWEKIRSVLIDDFFGTGTEQVLLLFKDSWNSDCRSSFEIMGHDAFNCSGETLDCNEDDLFDDKHGNCYLVVLPLERRLKVGFISIWELQQHLLLKEKIISKSYKALMNLFQRKDDSTLSAEEECLVTLCGEEENPVCTFNEKLSDNFQDLEQLVEKIWYRVIEDSLVIGVKATSSWKVSLNHVTLLLSVDQGSNSTFPLIKCQNKIFKLTRNSSPVLSSVPYEVGSEVKRIKLSVDSKEEKEESVVCEQPLKKEYVQMITAVTALPPLLTFSNFCCIVLLQMRENGNSSEAHYVQCGRIVLSVEDLSSGKCVLTFPERKPIEHMEDLFTLLAAWHRACFQITSPMFALTSVRVWLLEHMKCEVLKEFPEIWFCKRPGSFYGTLFNWKQRTPFEGILVVYSRNQTVLFQCLHDLSTVLPINSFFKYLELESEDFLIGHLAVALEKELVTLGSPPSALVKVETSLVQNCEVSKEKSSDDGAALSDIEKSIHLYRKELQREKEQMLGTNLKVSGALYREMTLKLAEVQLNSDLAAKQLTDL", "length": 852, "header": "tr|A0AAA9SC39-1|A0AAA9SC39_BOVIN Isoform 1 of FA complementation group B OS=Bos taurus OX=9913 GN=FANCB PE=4 SV=1 CANONICAL=A0AAA9SC39-1" }, "locus": { "chromosome": "X", "start_pos": 128661954, "end_pos": 128644820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101655.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101655.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079801.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079801.1" } ] } }, { "isoform_ac": "G3X787-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39/entry#G3X787-1", "sequence": { "sequence": "MSSTEQERFCCYNGEVLIFHLSEGNFVDEGPKKTPVLHVRRMVFGRGPEGFVQKSTGFFSIKEEYSHLKIMCCDCVSDFRTGINLPYVMIQCIKEENIFKYFLLFLHGTNKFEKCLSFRLGYELKDSIRVLNGPLVLWRHGQTFFYISSQTGKVVTVPMNFSSVEWAGEIENLGMVLLGPKRCYLSAEGCTPKPSKSDYATWNTHFCAYSLERAEIISDTYIIPPAYTSMITFVHVYSTEIVNDQLRMSLIALTQKNQLISFLNGTPTSVCQLPFGDPCAVQLVDSGEEELLFIISFKSSHACAVWEKSFQVAAKWEKIRSVLIDDFFGTGTEQVLLLFKDSWNSDCRSSFEIMGHDAFNCSGETLDCNEDDLFDDKHGNCYLVVLPLERRLKVGFISIWELQQHLLLKEKIISKSYKALMNLFQRKDDSTLSAEEECLVTLCGEEENPVCTFNEKLSDNFQDLEQLVEKIWYRVIEDSLVIGVKATSSWKVSLNHVTLLLSVDQGSNSTFPLIKCQNKIFKLTRNSSPVLSSVPYEVGSEVKRIKLSVDSKEEKEESVVCEQPLKKEYVQMITAVTALPPLLTFSNFCCIVLLQMRENGNSSEAHYVQCGRIVLSVEDLSSGKCVLTFPERKPIEHMEDLFTLLAAWHRACFQITSPMFALTSVRVWLLEHMKCEVLKEFPEIWFCKRPGSFYGTLFNWKQRTPFEGILVVYSRNQTVLFQCLHDLSTVLPINSFFKYLELESEDFLIGHLAVALEKELVTLGSPPSALVKVETSLVQNCEVSKEKSSDDGAALSDIEKSIHLYRKELQREKEQMLGTNLKLRLGP", "length": 827, "header": "tr|G3X787-1|G3X787_BOVIN Computationally mapped isoform of FA complementation group B OS=Bos taurus OX=9913 GN=FANCB PE=4 SV=3 CANONICAL=A0AAA9SC39-1" }, "locus": { "chromosome": "X", "start_pos": 128689157, "end_pos": 128644820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021852.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021852.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021852.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021852.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616549", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616549", "resource": "KEGG Pathway" }, { "id": "R-BTA-6783310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" }, { "id": "R-BTA-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X9C3-1", "protein_name": "Fanconi anemia complementation group B", "gene_name": "FANCB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCGEIKMLLSEQQHVLAYNGELLVFQLSKAKRVEGAADRTAKLCVRRMAFDRDAQLFVQKSSGAFSVRAKHSETEIVCCDCATRSKTGVVLPCVLVKMKKHNGVVEHLLLLLHSSDRFEQCCHFRLDYELKEDVRLFAGPSVLWRHANKLFYVSSDTCTVLSAPVQLSSIAWMGEIEGEGTVVLGIRAACLPESEDGDEFSTSDRAIWGSEFFGYAIEMQKMLTGARFMPHAYSRVVSSVCVCKSERLQKQLRISAAAITQKNQLIWFQDGVPKGVCELPYEKPCLIKTAVTSSNDLLFIVSFSSGNICVVQRENLQVTSKWQKVKSVLVDDFIGSGTEQLLLLFNDDSNTDALNMFKITDFGKINYESGINYKDDVPAAEGLQENGLLTIQALETRLQAGLASVRELQQHLGLKKRVILQSCRALIDLVEGRNHILPSAKKEGLVSLWDDVGKPHSVSKEPSLTPKLQDHFIEKLWQRVVGDNLVVGVKLTESFCLSVSDISLSLVMDQDFSLISPIIECRNKIIKLNKVFSALSVSSCQIEPPQKKMKLDLRSKNDLKEEFHKRCSRTQLDKANTVTAVTSLSPLLAFHRVCCAVLLHAKKQKHQNGDLQKSKRMTLLCGKILLSLEDISNGKYSLNMLKDNSYCTGSMEDIAAILAVSIRSSFQILSSDCTLTRVNSWLLGEMECVPFKECHDMVFAHKAGNVYGTVFSWTLKSPFEGVLTLFCRSLTVLFQCLHSLIRVLPPRCDVKLMKSGSKGVLTEQLVLALEKEMFTSRSFLSSKESKAENNLTWWNEPGKKINDAPVASLLDSEDGVQQFRERLQNEKEQCMLSMNETMDGTLYQEVALKVAEAQLSSDMIVWRLSKS", "length": 867 }, "evidence": [ { "id": "A0AAA9SC39", "url": "https://omabrowser.org/oma/group/A0AAA9SC39/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JZ95-1", "protein_name": "Fanconi anemia group B protein", "gene_name": "Fancb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDGNQATPFNEQAKCLCYNGEILVFYLSKGDFEMPTDTSVLYVKRMAYDRETGTFVLISKGFLIIKEKASDLKILCCKCVSDFRTRINLPCILIQYKKYNSGAFKYYILFLHNSNKFEKYLSFKLNHALDESLKIFDGPIVLWQYLNKFFYISSQIGKVTNISVNLSSIEWVGEVENFGLIFLGLPEPPEAKCTHKLSESDYEFSNSTLCAYALTTQEILSNSYLIPLAYSNVITHVHVCAAEMVDDKLRMSLIALTRKNQLVLFQDGIPVRVCQLPFLDPCSVQILDSGKENRYFIVSFNSKACAVSEKKFKVVAKWKQVSIILTNDFLGVGTDQVLVIFEDVLNTDQLTSFAITDLIRITYSTEPLNCSQEPYPEDEHENYYLVLPALEAQLKASIVFLNKLQKHISFKDEFIVNSWKDFLNSIYGKVHSMSSNEEDCVVPFCDEDENSIHTPEENLSENFQEPKHIVEQTWCRVLDDDLVVGVKVTSLKISPNEMTLSLIMNQGNRSSFQLTKCQSQVTRLSMNSFPEAYLMPVETGPDIKRIKLTSSSKEEENSFCGQSPKAESTHVITAVTSLSPHLVFNKLCCTLLLNISDRDNGENSVHDCMVCDNLEFNLQDLFSMNHLLAFPEKESIEHMEDLLSLLAVLHKYCFHVTSPTGALNLMKVCLLKHMKCEIINGFREIYLYKKHQNYGTLFSWEPRTTFEGILTVYCRNQGVLFQCLDHIIKFLPEICFFKYLKLGNEDFIINNLSSTLEKELVTFCSLSTSAFEYVRDGFMHQCQTSKTNSCATTASEGMDKICLHKQEVQREKVIQDLNLKVNGCSYVEMTLALAETQLKSDLNVVKLTNL", "length": 850 }, "evidence": [ { "id": "A0AAA9SC39", "url": "https://omabrowser.org/oma/group/A0AAA9SC39/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0M142-1", "protein_name": "FA complementation group B", "gene_name": "Fancb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPFNEQAKFLCYNGEVLVFQLSGGEFADLEKPTDPSVLGVKRMIFDRETSTFLLISTVFLNINEKDSHLKILCCNCVSDFRTRINLPCILIQCRKYNSKAFKYYILFLHSPNQLEKLLSFELNHALDERAKIFDGPIVFWQYLNQFFYISSEIGKVTNISVSLSSIEWIGEIENFGLGFLGLADPSGDKYKCTRKLSESDYEFSNSSFCAYALKSQEMLSNSYLIPLAYSTVVTRVHVCAAEMVNKQLKMSLIALTRKNQLILFQNGIPVRTCQLPFLDPRSVQILDAGKRNRFFIVSFLSKACAVSEKKFKVVAKWEQLSLVLVNDFAGVGTEQVLVVFEDSLDADQLTSFTVTDFVKIWYSTKPLDCCEDPLAEEEHENYYLVLPALEAQLDNSFIFLNQFQQHISFKDKFIANSWKALLNSVYGNVDSMPSDEEVQLEQGGLVPFCDEDENSVPTPEENLPDNFPEPEHVIEQTWCHVLDDDLVVGVKVTSLKPSDGMTLSLIMDQANRSSFHLMKCQSQLISLSMNSFPETYLLSKETGPEIKRMKLTSGSQEEESSFCGQSAKAESTYVITAITSLSPLLVFNKLSCTVLLNVSDRDNPKNTVHDYVFCGHLDFNLQDLFSKNHLLAFPKKQSIEQTENLFSLLTALPKYAFCVTSPTHAPNLMKVWLLKHMKCAKIQECTEIYLYKKLRNCEALFSWEQRTAFEGILTIYCRSLGVLFQCLDHLIKVIPEICSFKYLRFENEDFLVDHLSSTLEAELVTFCSVSTSAFEYVRGGCMYNCSTSKTDNRATTFSGRRAKIRHYKRQVQREKILKHLNRTVNVSSYAEMTLALAEIQLRSDLIVKTLTDL", "length": 853 }, "evidence": [ { "id": "A0AAA9SC39", "url": "https://omabrowser.org/oma/group/A0AAA9SC39/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SQU9-1", "protein_name": "FA complementation group B", "gene_name": "FANCB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSNEQERLLCYNGEVLVFCLSKGNFVDKGPAKITMIHVRRMTFDRGTGVFVQKSTGSFSIKEEYSHLKIMCCNSVSDFRTGINLPYVMIQCNKENNIFRYFLLFLHSTNKFEKRLSFRLGYELKDSIRVLNGPLVLWRHVQTFFYISSQTGRVVTVSFNFSSIDWVGEIENLGIVLLGLKRYYLSEEGCTPKPSKSDYATWNTPFCVYSLEREEVLSDTYLIPPVYSSVVTCVHVCATEIVDNQLRLSLIALTQKNQLISFQNGTPKSVCQLPFEDPCAVHLMDSGGGNLHFIVSFRSNDACAVRAKNFQVVDKWEKMSSILVDDFLGTGTEQVLLLFKDSLSSDCLSSFKITNLDNINYSSQPVDCSQDDLFDNEQDNCSLMIPPLERRLKVSVYVCFQELQQNLLLKEKILSKSYKAFTNLFQGKDDSTPSAKEDYLVTLCGKEENPVCTSDEKLSENFQDSKQLVEKIWYRVIEDSLVVGVKTTSSLKVSLSHVTLSLSMHRACNSSFPGIKCQNRVLQLNRNSSPPPCLVPYEVRSEVKRIKLSVDSEQEEEKKESLVCEQPSEKDCVQMITAVTSLSPLLAFSNFCCIVLLQIRERENANYSKVHYVHCGRIFLSLEDLSSGKYLLTFPKKKPLEHMEDLFALLAVLHRACFQITSRSYALTSVKSWLLEHMECEVIKEFPEVCFCKRPGNFYGTFFSWKERTPFEGILIVYFRNQTVLFQCLHNLSRVLPVNSFFKNLKLGSEDILIDHLTLALEKELVTLGSLSSASAKVESNLVQSSEASEEKSSNVAASSDREERIHLYREELQREKQQTLGTNLNVSGALYREMTLKLAEVQLKSDLAAQKLTDL", "length": 856 }, "evidence": [ { "id": "A0AAA9SC39", "url": "https://omabrowser.org/oma/group/A0AAA9SC39/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NB91-1", "protein_name": "Fanconi anemia group B protein", "gene_name": "FANCB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSKQAMSSNEQERLLCYNGEVLVFQLSKGNFADKEPTKTPILHVRRMVFDRGTKVFVQKSTGFFTIKEENSHLKIMCCNCVSDFRTGINLPYIVIEKNKKNNVFEYFLLILHSTNKFEMRLSFKLGYEMKDGLRVLNGPLILWRHVKAFFFISSQTGKVVSVSGNFSSIQWAGEIENLGMVLLGLKECCLSEEECTQEPSKSDYAIWNTKFCVYSLESQEVLSDIYIIPPAYSSVVTYVHICATEIIKNQLRISLIALTRKNQLISFQNGTPKNVCQLPFGDPCAVQLMDSGGGNLFFVVSFISNNACAVWKESFQVAAKWEKLSLVLIDDFIGSGTEQVLLLFKDSLNSDCLTSFKITDLGKINYSSEPSDCNEDDLFEDKQENRYLVVPPLETGLKVCFSSFRELRQHLLLKEKIISKSYKALINLVQGKDDNTSSAEEKECLVPLCGEEENSVHILDEKLSDNFQDSEQLVEKIWYRVIDDSLVVGVKTTSSLKLSLNDVTLSLLMDQAHDSRFRLLKCQNRVIKLSTNPFPAPYLMPCEIGLEAKRVTLTPDSKKEESFVCEHPSKKECVQIITAVTSLSPLLTFSKFCCTVLLQIMERESGNCPKDRYVVCGRVFLSLEDLSTGKYLLTFPKKKPIEHMEDLFALLAAFHKSCFQITSPGYALNSMKVWLLEHMKCEIIKEFPEVYFCERPGSFYGTLFTWKQRTPFEGILIIYSRNQTVMFQCLHNLIRILPINCFLKNLKSGSENFLIDNMAFTLEKELVTLSSLSSAIAKHESNFMQRCEVSKGKSSVVAAALSDRRENIHPYRKELQREKKKMLQTNLKVSGALYREITLKVAEVQLKSDFAAQKLSNL", "length": 859 }, "evidence": [ { "id": "A0AAA9SC39", "url": "https://omabrowser.org/oma/group/A0AAA9SC39/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "pmid": "" }, { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via homologous recombination", "id": "GO:1905168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "pmid": "" }, { "name": "replication-born double-strand break repair via sister chromatid exchange", "id": "GO:1990414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990414", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 601, "end_pos": 603, "annotation": "n_glycosylation_sequon" }, { "start_pos": 716, "end_pos": 718, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 508, "end_pos": 510 }, { "start_pos": 526, "end_pos": 528 }, { "start_pos": 601, "end_pos": 603 }, { "start_pos": 716, "end_pos": 718 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBY1-1", "uniprot_ac": "A0AAA9SBY1", "uniprot_id": "A0AAA9SBY1_BOVIN", "mass": { "chemical_mass": 252677.0, "monoisotopic_mass": 252677.0 }, "refseq": { "ac": "NP_001193484", "name": "bridge-like lipid transfer protein family member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193484" }, "gene_names": [ { "name": "KIAA0100", "type": "recommended", "evidence": [ { "id": "A0AAA9SBY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1" } ] }, { "name": "KIAA0100", "type": "synonym", "evidence": [ { "id": "NP_001193484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193484" } ] } ], "protein_names": [ { "name": "KIAA0100", "type": "synonym", "evidence": [ { "id": "A0AAA9SBY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1/entry#names_and_taxonomy" } ] }, { "name": "bridge-like lipid transfer protein family member 2", "type": "synonym", "evidence": [ { "id": "NP_001193484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193484" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA0100", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1", "locus": { "chromosome": "19", "start_pos": 20060814, "end_pos": 20091057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011988", "url": "https://www.ensembl.org/id/ENSBTAG00000011988" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011988", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011988", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517133", "url": "https://www.ncbi.nlm.nih.gov/gene/517133", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517133", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517133", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WASFETK", "url": "https://omabrowser.org/oma/group/WASFETK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNA5", "url": "https://www.orthodb.org/?gene=A0A3Q1LNA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BD97", "url": "https://www.orthodb.org/?gene=E1BD97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15678:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15678:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193484", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNA5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD97", "url": "https://www.uniprot.org/uniprotkb/E1BD97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD97-1", "url": "https://www.uniprot.org/uniprotkb/E1BD97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLFFSALLALLLLGLSALFLVRWLVVRLATKWCQQKLQAELKIGSFFWIQNVSLKFQQHQQTVEIDSLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSSLFAPFSQSTGAHQKELAFSPSLLKICQLFSIHVDSINIMVLKVATSESLWHIQIRESSFLLDSDGKRLKCEVSLSQINSKVLKSGQLEDTCLAELSLALKLCLEVGISSGQLKAITVDVWTLHAELHEGLFHSQLLRQGTGLAPKPLPGSELTEDLAEPTLPGLYLLQQLPDQVKVKMEITSVVLSMNSQKRHLNWTLKLLHFLYHRDEDQLPLRSFTANSDVAQMSTELLLKDGLLLSQSRQRIVCLNCLKANVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHMLALETQESSSSVLKQRKDRAFPQILAPIIFSTSISNVNVSIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEVSDTCAQCLSRIFSLMGPQSGKSAVSRESSFGESVSLLWKVDLKVEDMNLFTLSALVGASEIRLDTLTVLGSAETSTVGVQGLVLALVKSVTEKMQPCCKAPDIPTPVLSFSMLSVTYHSSIRSLEVQCGSGLTLLWSPPDHMYLYQHVLATLQCRDLLRTTLFPETVPLVELETAATPSEPEGCPPESSPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFSFKEVEVQLLPELEEMILHRNPFPGLQTLRNRVWLLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHGGSRSQASPSSAPLPPDILLKVQHFSWVFLDDIFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEHKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPERVLEQVRELDPGSPFPAEGIDLVIQWCRMLKCSVKTFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILPLGLPWGNVAIERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWNHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVTLRAPEFLPEVPLGQFHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGVQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQATVHLMASPAEENADHCLDPLVTKTHLLSLSSLTYQRHSSRTAEEEPSTRVGDSAFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPHLPAKKPKQSVPSSAPTPPPVSTPSFSGQPDKGSSGGAYMLKKLIEETDRFVVFTEEESGVSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCILDGMQYFATTESSPTEQDGPQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQIQRIISRCNCRMYYISYSHDIDPELATQIKPPEVPENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNLKLQLQLNQEKANLQLESEELNILIRCFKDFQLQQANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRIMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDTAPLGPGKGVAQGLNRSSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGNKNPGKKSIFGRRK", "length": 2232, "header": "tr|A0AAA9SBY1-1|A0AAA9SBY1_BOVIN Isoform 1 of KIAA0100 OS=Bos taurus OX=9913 GN=KIAA0100 PE=4 SV=1 CANONICAL=A0AAA9SBY1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1/entry#A0A3Q1LNA5-1", "sequence": { "sequence": "MSPSPSAKGTCSLALESRNRWLVVRLATKWCQQKLQAELKIGSFFWIQNVSLKFQQHQQTVEIDSLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSSLFAPFSQSTGAHQKELAFSPSLLKICQLFSIHVDSINIMVLKVATSESLWHIQIRESSFLLDSDGKRLKCEVSLSQINSKVLKSGQLEDTCLAELSLALKLCLEVGISSGQLKAITVDVWTLHAELHEGLFHSQLLRQGTGLAPKPLPGSELTEDLAEPTLPGLYLLQQLPDQVKVKMEITSVVLSMNSQKRHLNWTLKLLHFLYHRDEDQLPLRSFTANSDVAQMSTELLLKDGLLLSQSRQRIVCLNCLKANVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHMLALETQESSSSVLKQRKDRAFPQILAPIIFSTSISNVNVSIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEVSDTCAQCLSRIFSLMGPQSGKSAVSRESSFGESVSLLWKVDLKVEDMNLFTLSALVGASEIRLDTLTVLGSAETSTVGVQGLVLALVKSVTEKMQPCCKAPDIPTPVLSFSMLSVTYHSSIRSLEVQCGSGLTLLWSPPDHMYLYQHVLATLQCRDLLRTTLFPETVPLVELETAATPSEPEGCPPESSPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFSFKEVEVQLLPELEEMILHRNPFPGLQTLRNRVWLLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHGGSRSQASPSSAPLPPDILLKVQHFSWVFLDDIFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEHKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPERVLEQVRELDPGSPFPAEGIDLVIQWCRMLKCSVKTFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILPLGLPWGNVAIERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWNHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVTLRAPEFLPEVPLGQFHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGVQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQATVHLMASPAEENADHCLDPLVTKTHLLSLSSLTYQRHSSRTAEEEPSTRVGDSAFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPHLPAKKPKQSVPSSAPTPPPVSTPSFSGQPDKGSSGGAYMLKKLIEETDRFVVFTEEESGVSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCILDGMQYFATTESSPTEQDGPQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQIQRIISRCNCRMYYISYSHDIDPELATQIKPPEVPENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNLKLQLQLNQEKANLQLESEELNILIRCFKDFQLQQANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRIMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDTAPLGPGKGVAQGLNRSSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGNKNPGKKSIFGRRK", "length": 2229, "header": "tr|A0A3Q1LNA5-1|A0AAA9SBY1_BOVIN Computationally mapped isoform of KIAA0100 OS=Bos taurus OX=9913 GN=KIAA0100 PE=4 SV=2 CANONICAL=A0AAA9SBY1-1" }, "locus": { "chromosome": "19", "start_pos": 20087751, "end_pos": 20061347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066745.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066745.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058280.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058280.2" } ] } }, { "isoform_ac": "A0AAA9RZF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1/entry#A0AAA9RZF4-1", "sequence": { "sequence": "MSVVGRYPALSFWSHAFTSRKQPVGPAGSRASGGAGQGDGWLAGWRAAGGGAQARQRFLAQRSPCACCWSARGGAARSWRGGRREGVAPRQGGGRSQAGPGPGPEPGRAGAGMPLFFSALLALLLLGLSALFLVRWLVVRLATKWCQQKLQAELKIGSFFWIQNVSLKFQQHQQTVEIDSLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSSLFAPFSQSTGAHQKELAFSPSLLKICQLFSIHVDSINIMVLKVATSESLWHIQIRESSFLLDSDGKRLKCEVSLSQINSKVLKSGQLEDTCLAELSLALKLCLEVGISSGQLKAITVDVWTLHAELHEGLFHSQLLRQGTGLAPKPLPGSELTEDLAEPTLPGLYLLQQLPDQVKVKMEITSVVLSMNSQKRHLNWTLKLLHFLYHRDEDQLPLRSFTANSDVAQMSTELLLKDGLLLSQSRQRIVCLNCLKANVQFRCARFQVTTIDLSASLVLNTCIIHYRHQEFSHWLHMLALETQESSSSVLKQRKDRAFPQILAPIIFSTSISNVNVSIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEVSDTCAQCLSRIFSLMGPQSGKSAVSRESSFGESVSLLWKVDLKVEDMNLFTLSALVGASEIRLDTLTVLGSAETSTVGVQGLVLALVKSVTEKMQPCCKAPDIPTPVLSFSMLSVTYHSSIRSLEVQCGSGLTLLWSPPDHMYLYQHVLATLQCRDLLRTTLFPETVPLVELETAATPSEPEGCPPESSPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFSFKEVEVQLLPELEEMILHRNPFPGLQTLRNRVWLLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHGGSRSQASPSSAPLPPDILLKVQHFSWVFLDDIFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEHKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPERVLEQVRELDPGSPFPAEGIDLVIQWCRMLKCSVKTFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILPLGLPWGNVAIERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWNHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVTLRAPEFLPEVPLGQFHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGVQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQATVHLMASPAEENADHCLDPLVTKTHLLSLSSLTYQRHSSRTAEEEPSTRVGDSAFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPHLPAKKPKQSVPSSAPTPPPVSTPSFSGQPDKGSSGGAYMLKKLIEETDRFVVFTEEESGVSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCILDGMQYFATTESSPTEQDGPQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQIQRIISRCNCRMYYISYSHDIDPELATQIKPPEVPENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNLKLQLQLNQEKANLQLESEELNILIRCFKDFQLQQANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRIMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDTAPLGPGKGVAQGLNRSSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGNKNPGKKSIFGRRK", "length": 2351, "header": "tr|A0AAA9RZF4-1|A0AAA9SBY1_BOVIN Computationally mapped isoform of KIAA0100 OS=Bos taurus OX=9913 GN=KIAA0100 PE=4 SV=1 CANONICAL=A0AAA9SBY1-1" }, "locus": { "chromosome": "19", "start_pos": 20088488, "end_pos": 20061347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107514.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107514.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075177.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075177.1" } ] } }, { "isoform_ac": "A0AAA9SBY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1/entry#A0AAA9SBY1-1", "sequence": { "sequence": "MPLFFSALLALLLLGLSALFLVRWLVVRLATKWCQQKLQAELKIGSFFWIQNVSLKFQQHQQTVEIDSLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSSLFAPFSQSTGAHQKELAFSPSLLKICQLFSIHVDSINIMVLKVATSESLWHIQIRESSFLLDSDGKRLKCEVSLSQINSKVLKSGQLEDTCLAELSLALKLCLEVGISSGQLKAITVDVWTLHAELHEGLFHSQLLRQGTGLAPKPLPGSELTEDLAEPTLPGLYLLQQLPDQVKVKMEITSVVLSMNSQKRHLNWTLKLLHFLYHRDEDQLPLRSFTANSDVAQMSTELLLKDGLLLSQSRQRIVCLNCLKANVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHMLALETQESSSSVLKQRKDRAFPQILAPIIFSTSISNVNVSIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEVSDTCAQCLSRIFSLMGPQSGKSAVSRESSFGESVSLLWKVDLKVEDMNLFTLSALVGASEIRLDTLTVLGSAETSTVGVQGLVLALVKSVTEKMQPCCKAPDIPTPVLSFSMLSVTYHSSIRSLEVQCGSGLTLLWSPPDHMYLYQHVLATLQCRDLLRTTLFPETVPLVELETAATPSEPEGCPPESSPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFSFKEVEVQLLPELEEMILHRNPFPGLQTLRNRVWLLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHGGSRSQASPSSAPLPPDILLKVQHFSWVFLDDIFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEHKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPERVLEQVRELDPGSPFPAEGIDLVIQWCRMLKCSVKTFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILPLGLPWGNVAIERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWNHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVTLRAPEFLPEVPLGQFHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGVQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQATVHLMASPAEENADHCLDPLVTKTHLLSLSSLTYQRHSSRTAEEEPSTRVGDSAFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPHLPAKKPKQSVPSSAPTPPPVSTPSFSGQPDKGSSGGAYMLKKLIEETDRFVVFTEEESGVSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCILDGMQYFATTESSPTEQDGPQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQIQRIISRCNCRMYYISYSHDIDPELATQIKPPEVPENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNLKLQLQLNQEKANLQLESEELNILIRCFKDFQLQQANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRIMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDTAPLGPGKGVAQGLNRSSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGNKNPGKKSIFGRRK", "length": 2232, "header": "tr|A0AAA9SBY1-1|A0AAA9SBY1_BOVIN Isoform 1 of KIAA0100 OS=Bos taurus OX=9913 GN=KIAA0100 PE=4 SV=1 CANONICAL=A0AAA9SBY1-1" }, "locus": { "chromosome": "19", "start_pos": 20088152, "end_pos": 20061347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103739.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103739.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082892.1" } ] } }, { "isoform_ac": "E1BD97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1/entry#E1BD97-1", "sequence": { "sequence": "MTGNHGCVWKLQPFTLEWLVVRLATKWCQQKLQAELKIGSFFWIQNVSLKFQQHQQTVEIDSLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSSLFAPFSQSTGAHQKELAFSPSLLKICQLFSIHVDSINIMVLKVATSESLWHIQIRESSFLLDSDGKRLKCEVSLSQINSKVLKSGQLEDTCLAELSLALKLCLEVGISSGQLKAITVDVWTLHAELHEGLFHSQLLRQGTGLAPKPLPGSELTEDLAEPTLPGLYLLQQLPDQVKVKMEITSVVLSMNSQKRHLNWTLKLLHFLYHRDEDQLPLRSFTANSDVAQMSTELLLKDGLLLSQSRQRIVCLNCLKANVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHMLALETQESSSSVLKQRKDRAFPQILAPIIFSTSISNVNVSIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEVSDTCAQCLSRIFSLMGPQSGKSAVSRESSFGESVSLLWKVDLKVEDMNLFTLSALVGASEIRLDTLTVLGSAETSTVGVQGLVLALVKSVTEKMQPCCKAPDIPTPVLSFSMLSVTYHSSIRSLEVQCGSGLTLLWSPPDHMYLYQHVLATLQCRDLLRTTLFPETVPLVELETAATPSEPEGCPPESSPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFSFKEVEVQLLPELEEMILHRNPFPGLQTLRNRVWLLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHGGSRSQASPSSAPLPPDILLKVQHFSWVFLDDIFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEHKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPERVLEQVRELDPGSPFPAEGIDLVIQWCRMLKCSVKTFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILPLGLPWGNVAIERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWNHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVTLRAPEFLPEVPLGQFHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGVQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQATVHLMASPAEENADHCLDPLVTKTHLLSLSSLTYQRHSSRTAEEEPSTRVGDSAFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPHLPAKKPKQSVPSSAPTPPPVSTPSFSGQPDKGSSGGAYMLKKLIEETDRFVVFTEEESGVSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCILDGMQYFATTESSPTEQDGPQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQIQRIISRCNCRMYYISYSHDIDPELATQIKPPEVPENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNLKLQLQLNQEKANLQLESEELNILIRCFKDFQLQQANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRIMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDTAPLGPGKGVAQGLNRSSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGNKNPGKKSIFGRRK", "length": 2226, "header": "tr|E1BD97-1|A0AAA9SBY1_BOVIN Computationally mapped isoform of KIAA0100 OS=Bos taurus OX=9913 GN=KIAA0100 PE=4 SV=4 CANONICAL=A0AAA9SBY1-1" }, "locus": { "chromosome": "19", "start_pos": 20090998, "end_pos": 20061347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015910.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015910.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015910.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015910.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1509, "start_aa": "Thr", "end_pos": 1509, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1509", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1515, "start_aa": "Thr", "end_pos": 1515, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1515", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 708, "start_aa": "Thr", "end_pos": 708, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr708", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517133", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517133", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AND3-1", "protein_name": "KIAA0100", "gene_name": "KIAA0100", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPLFFSALLALLLVALIALFLGRWLVVRLATSWCQRKLKAELKIGSFFWIQNVSLKFQQHQQTVEIDSLRISSKLLSHDLPHYVALCFGEVRIRTDLQKVSGLFAPFSQNAGVHQKELSFSPSLLKIFCQLFSIHVDSVNIMVLKVATSESLWHIQIRDCSFLLDSDGKRLKCGVSLSQINSKVLKSGQLEDTCLAELSLALELCLEVGISSWQLKAITVDVWTLHAELHEGLFHSQLLRQGPGLAPKPVPGSEVTENLAEPTLPGLYLLQQLPDQVKVKMEITSVVLSMNSQKRHLNWTLKLLHFLYHRDEDQLPLRSFTANSDLAQMSTELLLKDGLLLSQSRQRIVCLNSLKASVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHMLTPEAQESSSSVLKQRKKRTFPQILAPIIFSTSISNVNVSIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGRQSGQSAVPRESSFGDLVSLLWKVDLKVEDMNLFTLSSLVGASEIRLDTLTVLGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRALEVQCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATLFPETVPLLALETPGTASEPEGCPPESSPPKRLLNLTLEVSTAKLTAFVAENKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPVLQTLRNRVWFLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHRGTHAQASPSPAPLPPDLLLKVQHFSWVFLDDIFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEHKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPERVVEQVRELDPGSPFPAEGMDLVIQWCRMLKCSVKTFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGDVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQSVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWNHLSFHWKPGQFVFKGDLDVNVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVYLMASPTEENADHCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSTRVGDPAFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPQMPAKKPKQNAGTSAPAPPPVSTPSFSGQPDKGSSGGTYMLQKLIEETDRFVVFTEEESGVSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVHENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQQANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRIMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAAPLGPGKGVAQGLNRSSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLKLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGAEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGNKNPGKKSIFGRRK", "length": 2233 }, "evidence": [ { "id": "A0AAA9SBY1", "url": "https://omabrowser.org/oma/group/A0AAA9SBY1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AME7-1", "protein_name": "Bridge-like lipid transfer protein family member 2", "gene_name": "KIAA0100", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLPPGLSLPLPAALLGLGLVLLLAGLLARWLACRLAVTWCRQKLQAELKIGSFGFFWAQNISLTFQREQQTVEIDNIWISSKLSRELPRYFELCFGEVRIRTDLQKSHGLQSSFPEAPKEADDGKNKADLALKPSLLRLLSQLFSIHMDSINIMVLHVATSESLWHIQASKTRLLLNGDGKSLNCEVNLTKVNSKVLRSSQLDDTCLAELALALSISLEISSKRRLVGVRLSVRTLQAELHEGLFCSPLLHRVIARAPQPSPDSAESLKSPSLLSRDTLQLIPKRVEVKLESTSVVLSMNSQKRHLTWSLKLLQFLYQREEEQIPLRNFTPTSDLDQMSVDLHLEDGLLLSQSRQRIVCLNSLKTSVQVTAIDLSAAVLLNTCIIHYRHQEFSHWLGLLAQEHRHHSAPVPSQGHKGRCYPQIIAPIILSASLSNVNVSVQLGDTPPFALGFNSISADYQHLRPQSVHQRAMLAVDHLCWRVGNDSHIQRAPHPPNMHVWGEALILDSFNLQGSYNQPLGMSSAQSDTLFLDCTIRGLQVESSDTCTECLARVLPLFCPQPSEAELAQQLSSAQSEPWILLWKVDLKVEDVNLFTLSAVVGALELRLDTLTVLGSAESCTVSVQGMVLALVKSITEKMQPCCKAPAIPNPVANLSMLSITYHSSIRSLEVQCGEGLAVLWSPPDHMHLYHHTLATLQCLEALRSAIGHGTPPSLTPQSPASPMATPTETLEPLQPDGAPPKRLLSLSLELSSAKVTAFVSEANYISLAAERTSVSWHGGALHGYCPELAAGFDGHSIFSFKEVEVKLLPELEEVILHRCAFPTLHTLRNRGWAFSFASVTIEFPYQYDFSRTLDAAVGVQKWLKGLHRRGRPAGTALPPDLLLKVTHFSWVFLDDVFEVKLRDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLEKKNIEIYIQRSRRLYANTPMRRALLTWTLSHLELVAMADESFHGTERVVEQMRDIDSVSPFPPEGLEMVTQWCRMMKGSIGSFFVRIRDYPRYLFEIRNWQLSGRLIGAEQCGQACSRRRQVLKLGLPWGDATVERNMPPLKFYHDFHSEISQYTIVWGPCWDPAWTLIGQCVDLLTKPSEDPSAPLSWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGNLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHGVVLRSPEFLPEVPVGQQYDSYRAFRSENLNLSIRMDLTRLSEEHSQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNMKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQVECCQGHIFTRGTQRLIPQAGTVMRRLISEWSITQMVSDLSQVTVHLMASTCDENADHRLDTLVKKTHLLSLSSLTYQRHSNRTAEEELPLRDGDDGFHTHQLHLVDLRASWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDTQLQAKKLKRGPLSAHSAPAKVTAPITSGRSERASSGGAYMLQKLIEETDKFVVFTEEESGASEQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEREHGQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVSTTTDWNQPSEAQQTQQVQRIISRCSCRMYYISYSHDIDPELATQIKPPETPANQEKEDLLKKQEGAVDTFTLIHHDLEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSNVKSLQDDSKNESLLDLNHKLQQQLSQEKADLQLESEELNILIRCFKDFQLQRANKMELRKQPEDVSVARRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWVTMNNLLPNAVYKVVLRPQSSCQSGRQLALRIFSKVRPPVGGISIKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGRNVEEEEVGDEEDKSKLVTTGIPVVKPRQLIGADDSLGPGKGVTQGLNRTSGVRRSFRKAPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPAAGAEARGKLENKSDGTIQQQEEDEKARLLIGLSVGEKNPSKKSIFGRRK", "length": 2245 }, "evidence": [ { "id": "A0AAA9SBY1", "url": "https://omabrowser.org/oma/group/A0AAA9SBY1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q14667-1", "protein_name": "Bridge-like lipid transfer protein family member 2", "gene_name": "BLTP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLFFSALLVLLLVALSALFLGRWLVVRLATKWCQRKLQAELKIGSFRFFWIQNVSLKFQQHQQTVEIDNLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSDLSAPFSQSAGVDQKELSFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQISRSRFLLDSDGKRLICEVSLCKINSKVLKSGQLEDTCLVELSLALDLCLKVGISSRHLTAITVDVWTLHAELHEGLFQSQLLCQGPSLASKPVPCSEVTENLVEPTLPGLFLLQQLPDQVKVKMENTSVVLSMNSQKRHLTWTLKLLQFLYHRDEDQLPLRSFTANSDMAQMSTELLLEDGLLLSQSRQRIVCLNSLKASVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHLLALETQGSSSPVLKQRKKRTFPQILAPIIFSTSISNVNISIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGASEVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHQGTRAWASPSPVPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTEENADHCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDGDPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPQMPAKKPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSVGDKNPGKKSIFGRRK", "length": 2235 }, "evidence": [ { "id": "A0AAA9SBY1", "url": "https://omabrowser.org/oma/group/A0AAA9SBY1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SYL3-1", "protein_name": "Bridge-like lipid transfer protein family member 2", "gene_name": "Bltp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLFLSALLVLLLVALSALFLGRWLVVRLATRWCQRKLQAELKIGSFRFFWIQNVSLKFQQHQQTVEIDNLWISSKLLSHDLPNYVALCFGEVRIRTDLQKVSSLSAPFSQNTEVEQKELSLSPSLLKIFCQLFSIHVDAINIMVLKVATSESLWHIQISRSRFLLDSDGKSLICKVNLSKINSKVLKSGQLEDTCLVELSLALDLRLQVSVSSWHLTAVTVDVWTLHAELHEGLFHSQLLCHAPGRISKSVSCSDLTENFAEPTLPGLYLLQRLPDQVKVKMENTSVVLSMNSQKRHLTWTLKLLHFLYHRDEDQLPLRSFTANYDMAQMSTELLLEDGLLLSQSRQRIVCLNSLKANVQVTTIDLSASLVLNTCIIHYRHQEFSHWLLMLALETQGASSPDLKQRKKRTFPQILAPIIFSTSVSNVSISIQLGDTPPFALGFNSISLDYQHLRPQSIHQRAVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSNTLFLDCTIRGLQVEISDICAQCLSRVLSLVIPQSERSAVSRKSSLGESVTLLWKVDLKVEDMNLFTLSALVGASELRLDTLTVLGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLGLSMLSLTYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVRATLQCRDLLRATVFPEIIESHSLNTPQSTWEPEDHLPESSLPRRLLTLTLEVSTAKLTAFVAEDKFITLAAESVSLNRHGGSLQAYCPELAAGFDGNSIFNLKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSLGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHRGTHAWASPSPAPLPPDLLLKVQHFSWVFLDDIFEVKLHDNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLELVALADASFHGPEHVIEQVRELDPGSPFPAEGMDLVTQWCRMLKCNVKTFLVRIRDYPRYLFEIRDWRLMGRLAGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFRGDLDVNVRTASKYDDCCFLHLPDLCMTLDLQWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSGTISQPRILVYSSTLRWMQNFWATWTSITRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISEWSVTQMVSDLSQVTVHLMASPTEENADHCLDPLITKTHLLSLSSLTYQRHSNRTTEEELSARDGDPAFHTHQLYLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPQMSAKKPKRGIPPSAQVPPHVSTPSFSGRPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRERSLDSVQELMESGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVHENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRHLEKQMYSIMKSLQDDSKNENLLDLNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAIYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLSHRFFHRMMGFFFPGRNVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGSGKGVAQGLTRSSGVRRSFRKLPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLETKCDLNMQQQEEEKARLLIGLSVGDKNPGKKSIFGRRK", "length": 2234 }, "evidence": [ { "id": "A0AAA9SBY1", "url": "https://omabrowser.org/oma/group/A0AAA9SBY1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1156, "end_pos": 1158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1253, "end_pos": 1255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1479, "end_pos": 1481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1940, "end_pos": 1942, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2079, "end_pos": 2081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2109, "end_pos": 2111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2149, "end_pos": 2151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 727, "end_pos": 729, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY1" }, { "id": "SM01214", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit", "eco_id": "ECO_0000259", "start_pos": 1025, "end_pos": 1157, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 708, 1509, 1515 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1156, "end_pos": 1158 }, { "start_pos": 1253, "end_pos": 1255 }, { "start_pos": 1479, "end_pos": 1481 }, { "start_pos": 1940, "end_pos": 1942 }, { "start_pos": 2079, "end_pos": 2081 }, { "start_pos": 2109, "end_pos": 2111 }, { "start_pos": 2149, "end_pos": 2151 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 426, "end_pos": 428 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 727, "end_pos": 729 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCN4-1", "uniprot_ac": "A0AAA9SCN4", "uniprot_id": "A0AAA9SCN4_BOVIN", "mass": { "chemical_mass": 68445.0, "monoisotopic_mass": 68445.0 }, "refseq": {}, "gene_names": [ { "name": "MATN4", "type": "recommended", "evidence": [ { "id": "A0AAA9SCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4" } ] } ], "protein_names": [ { "name": "Matrilin-4", "type": "recommended", "evidence": [ { "id": "A0AAA9SCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Major component of the extracellular matrix of cartilage.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LP67", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP67#function" }, { "database": "UniProtKB", "id": "ARBA00055899", "url": "https://www.uniprot.org/uniprotkb/ARBA00055899#function" }, { "database": "UniProtKB", "id": "E1BDF3", "url": "https://www.uniprot.org/uniprotkb/E1BDF3#function" }, { "database": "UniProtKB", "id": "A0AAA9SCN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MATN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4", "locus": { "chromosome": "13", "start_pos": 73636238, "end_pos": 73650595, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011279", "url": "https://www.ensembl.org/id/ENSBTAG00000011279" } ] } } ], "crossref": [ { "id": "A0AAA9SCN4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011279", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011279", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01475", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01475", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LP67", "url": "https://www.orthodb.org/?gene=A0A3Q1LP67", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDF3", "url": "https://www.orthodb.org/?gene=E1BDF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10393", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10393", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LP67", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP67-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF3", "url": "https://www.uniprot.org/uniprotkb/E1BDF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGLLRWPLLLLLLQPWETQLQLAGPRCSSGPLDLVFVIDSSRSVRPFEFETMRQFLVGLLRSLDVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRAVVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEAHVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLNEHVFLVESFDLIQEFGRQFQGRLCRKDLCAQGGHGCQHQCVSTRGTFHCACNPGYQLAADNKSCMALDLCTEGDHGCEHQCVSMPGSYFCRCQAGFVLQQEQRSCRAIDHCSFGNHSCQHDCVSIYGGPQCRCREGYDLLPDGRSCQARDLCNGVDHGCEFQCVSEGFSYRCVCPEGRQLQADGKSCSRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDNISVWAARAKEEGIVMYAVGVGKAVEEELREIASEPAELHVSYSPDFSTMTHLLENLKGSICPEEGIGAGTELRSPCECESLVEFQGRTLGALESLSQKLAQLTARLEDLENQLATQK", "length": 622, "header": "tr|A0AAA9SCN4-1|A0AAA9SCN4_BOVIN Isoform 1 of Matrilin-4 OS=Bos taurus OX=9913 GN=MATN4 PE=4 SV=1 CANONICAL=A0AAA9SCN4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4/entry#A0A3Q1LP67-1", "sequence": { "sequence": "MRGLLYSLLPLLLLLLQPWETQLQLAGPRCSSGPLDLVFVIDSSRSVRPFEFETMRQFLVGLLRSLDVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRAVVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEAHVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLNEHVFLVESFDLIQEFGRQFQGRLCRKDLCAQGGHGCQHQCVSTRGTFHCACNPGYQLAADNKSCMAIDHCSFGNHSCQHDCVSIYGGPQCRCREGYDLLPDGRSCQARDLCNGVDHGCEFQCVSEGFSYRCVCPEGRQLQADGKSCSRIGCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDNISVWAARAKEEGIVMYAVGVGKAVEEELREIASEPAELHVSYSPDFSTMTHLLENLKGSICPEEGIGAGTELRSPCECESLVEFQGRTLGALESLSQKLAQLTARLEDLENQLATQK", "length": 585, "header": "tr|A0A3Q1LP67-1|A0AAA9SCN4_BOVIN Computationally mapped isoform of Matrilin-4 OS=Bos taurus OX=9913 GN=MATN4 PE=4 SV=2 CANONICAL=A0AAA9SCN4-1" }, "locus": { "chromosome": "13", "start_pos": 73648337, "end_pos": 73636539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073214.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073214.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058696.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058696.2" } ] } }, { "isoform_ac": "A0AAA9SCN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4/entry#A0AAA9SCN4-1", "sequence": { "sequence": "MRGLLRWPLLLLLLQPWETQLQLAGPRCSSGPLDLVFVIDSSRSVRPFEFETMRQFLVGLLRSLDVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRAVVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEAHVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLNEHVFLVESFDLIQEFGRQFQGRLCRKDLCAQGGHGCQHQCVSTRGTFHCACNPGYQLAADNKSCMALDLCTEGDHGCEHQCVSMPGSYFCRCQAGFVLQQEQRSCRAIDHCSFGNHSCQHDCVSIYGGPQCRCREGYDLLPDGRSCQARDLCNGVDHGCEFQCVSEGFSYRCVCPEGRQLQADGKSCSRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDNISVWAARAKEEGIVMYAVGVGKAVEEELREIASEPAELHVSYSPDFSTMTHLLENLKGSICPEEGIGAGTELRSPCECESLVEFQGRTLGALESLSQKLAQLTARLEDLENQLATQK", "length": 622, "header": "tr|A0AAA9SCN4-1|A0AAA9SCN4_BOVIN Isoform 1 of Matrilin-4 OS=Bos taurus OX=9913 GN=MATN4 PE=4 SV=1 CANONICAL=A0AAA9SCN4-1" }, "locus": { "chromosome": "13", "start_pos": 73648337, "end_pos": 73636539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104568.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104568.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083149.1" } ] } }, { "isoform_ac": "E1BDF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4/entry#E1BDF3-1", "sequence": { "sequence": "MRGLLRWPLLLLLLQPWETQLQLAGPRCSSGPLDLVFVIDSSRSVRPFEFETMRQFLVGLLRSLDVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRAVVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEAHVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLNEHVFLVESFDLIQEFGRQFQGRLCTLDLCTEGDHGCEHQCVSMPGSYFCRCQAGFVLQQEQRSCRAIDHCSFGNHSCQHDCVSIYGGPQCRCREGYDLLPDGRSCQARDLCNGVDHGCEFQCVSEGFSYRCVCPEGRQLQADGKSCSRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDNISVWAARAKEEGIVMYAVGVGKAVEEELREIASEPAELHVSYSPDFSTMTHLLENLKGSICPEEGIGAGTELRSPCECESLVEFQGRTLGALESLSQKLAQLTARLEDLENQLATQK", "length": 581, "header": "tr|E1BDF3-1|A0AAA9SCN4_BOVIN Computationally mapped isoform of Matrilin-4 OS=Bos taurus OX=9913 GN=MATN4 PE=4 SV=4 CANONICAL=A0AAA9SCN4-1" }, "locus": { "chromosome": "13", "start_pos": 73648337, "end_pos": 73636539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014986.8", "url": "https://www.ensembl.org/id/ENSBTAT00000014986.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014986.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014986.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN4" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 213, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 505, "end_pos": 507 }, { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAW6-1", "uniprot_ac": "A0AAA9SAW6", "uniprot_id": "A0AAA9SAW6_BOVIN", "mass": { "chemical_mass": 10035.0, "monoisotopic_mass": 10035.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "KRAB domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SAW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SAW6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052265", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052265", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232:SF157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232:SF157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9843940", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843940", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LPC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKENVSGIALSQLTFKDVFIDFTPEEWECLDPAQRTLYKDVMVETLRILLWVRITSFRSGGILWGTSACSLCVSWEPLFFLLRSKPC", "length": 87, "header": "tr|A0AAA9SAW6-1|A0AAA9SAW6_BOVIN Isoform 1 of KRAB domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SAW6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6/entry#A0A3Q1LPC3-1", "sequence": { "sequence": "ACWNVFSFPTQLTFKDVFIDFTPEEWECLDPAQRTLYKDVMVETLRILLWVRITSFRSGGILWGTSACSLCVSWEPLFFLLRSKPC", "length": 86, "header": "tr|A0A3Q1LPC3-1|A0AAA9SAW6_BOVIN Computationally mapped isoform of KRAB domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SAW6-1" }, "locus": { "chromosome": "18", "start_pos": 58998498, "end_pos": 58998238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085586.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085586.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056755.2" } ] } }, { "isoform_ac": "A0AAA9SAW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6/entry#A0AAA9SAW6-1", "sequence": { "sequence": "MKENVSGIALSQLTFKDVFIDFTPEEWECLDPAQRTLYKDVMVETLRILLWVRITSFRSGGILWGTSACSLCVSWEPLFFLLRSKPC", "length": 87, "header": "tr|A0AAA9SAW6-1|A0AAA9SAW6_BOVIN Isoform 1 of KRAB domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SAW6-1" }, "locus": { "chromosome": "18", "start_pos": 59002743, "end_pos": 58998238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133789.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133789.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083242.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083242.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9843940", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843940", "resource": "Reactome", "description": "Regulation of endogenous retroelements by KRAB-ZFP proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW6" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 87, "start_aa": "Leu", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE66-1", "uniprot_ac": "A0AAA9SE66", "uniprot_id": "A0AAA9SE66_BOVIN", "mass": { "chemical_mass": 40575.0, "monoisotopic_mass": 40575.0 }, "refseq": { "ac": "XP_005218357", "name": "leucine-rich repeat-containing protein 74B isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218357" }, "gene_names": [ { "name": "LRRC74B", "type": "recommended", "evidence": [ { "id": "A0AAA9SE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66" } ] }, { "name": "LRRC74B", "type": "synonym", "evidence": [ { "id": "XP_005218357", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218357" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 74B", "type": "synonym", "evidence": [ { "id": "A0AAA9SE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 74B isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005218357", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218357" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC74B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66", "locus": { "chromosome": "17", "start_pos": 72349415, "end_pos": 72362315, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053023", "url": "https://www.ensembl.org/id/ENSBTAG00000053023" } ] } } ], "crossref": [ { "id": "A0AAA9SE66", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053023", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053023", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530264", "url": "https://www.ncbi.nlm.nih.gov/gene/530264", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530264", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530264", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QGPEANW", "url": "https://omabrowser.org/oma/group/QGPEANW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQ15", "url": "https://www.orthodb.org/?gene=A0A3Q1LQ15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24114:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24114:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218357", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218357", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ15", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ15-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGPLQEPGEKEGQEEGAAAASGCPAGVREAKKGLDADSDSDQETEGARKPGELGKDTLYLRSCRAYSVVPASCFLRQGSAPELSLRHRGLGPQGARALAHALNSNPCIKRLDLRDNGLCGAGAEALAGALSRSCSICDVDLSENRLGAEGAQAICAALAVSPAVQRLQLAGNGLEEQAAQCLAELLLAHTGLKSLDLSYNQLNDQAGETLGPALAENTGLMELNVSWNHLRGLGAIAIARGLEANIFLRVLDISYNGCGDSGASAVGEALKTNNVLEELYMSNNRISAAGALSLGLGLRVNQTLRILAVSRNPMRSEGCSGVLKSVQANPQSVLELLDFSDIQVNREFDDLASSVKVILPGLCIKMAARRVEYKKELLAIFTPSE", "length": 386, "header": "tr|A0AAA9SE66-1|A0AAA9SE66_BOVIN Isoform 1 of Leucine rich repeat containing 74B OS=Bos taurus OX=9913 GN=LRRC74B PE=4 SV=1 CANONICAL=A0AAA9SE66-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66/entry#A0A3Q1LQ15-1", "sequence": { "sequence": "MRGPLQEPGEKEGQEEGAAAASGCPAGVREAKKGLDADSDSDQETEGARKPGELGKDTLYLRSCRAYSVVPASCFLRQGSAPELSLRHRGLGPQGARALAHALNSNPCIKRLDLRDNGLCGAGAEALAGALSRSCSICDVDLSENRLGAEGAQAICAALAVSPAVQRLQLAGNGLEEQAAQCLAELLLAHTGLKSLDLSYNQLNDQAGETLGPALAENTGLMELNVSWNHLRGLGAIAIARGLEANIFLRVLDISYNGCGDSGASAVGEALKTNNVLEELYMSNNRISAAGALSLGLGLRVNQTLRILADIQVNREFDDLASSVKVILPGLCIKMAARRVEYKKELLAIFTPSE", "length": 354, "header": "tr|A0A3Q1LQ15-1|A0AAA9SE66_BOVIN Computationally mapped isoform of Leucine rich repeat containing 74B OS=Bos taurus OX=9913 GN=LRRC74B PE=4 SV=2 CANONICAL=A0AAA9SE66-1" }, "locus": { "chromosome": "17", "start_pos": 72362237, "end_pos": 72350419, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070032.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070032.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059120.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059120.2" } ] } }, { "isoform_ac": "A0AAA9SE66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE66/entry#A0AAA9SE66-1", "sequence": { "sequence": "MRGPLQEPGEKEGQEEGAAAASGCPAGVREAKKGLDADSDSDQETEGARKPGELGKDTLYLRSCRAYSVVPASCFLRQGSAPELSLRHRGLGPQGARALAHALNSNPCIKRLDLRDNGLCGAGAEALAGALSRSCSICDVDLSENRLGAEGAQAICAALAVSPAVQRLQLAGNGLEEQAAQCLAELLLAHTGLKSLDLSYNQLNDQAGETLGPALAENTGLMELNVSWNHLRGLGAIAIARGLEANIFLRVLDISYNGCGDSGASAVGEALKTNNVLEELYMSNNRISAAGALSLGLGLRVNQTLRILAVSRNPMRSEGCSGVLKSVQANPQSVLELLDFSDIQVNREFDDLASSVKVILPGLCIKMAARRVEYKKELLAIFTPSE", "length": 386, "header": "tr|A0AAA9SE66-1|A0AAA9SE66_BOVIN Isoform 1 of Leucine rich repeat containing 74B OS=Bos taurus OX=9913 GN=LRRC74B PE=4 SV=1 CANONICAL=A0AAA9SE66-1" }, "locus": { "chromosome": "17", "start_pos": 72362237, "end_pos": 72350419, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098083.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098083.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080680.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530264", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530264", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0L3X2-1", "protein_name": "Leucine rich repeat containing 74B", "gene_name": "Lrrc74b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVSVVVSPGKEHAKVVVHLQTRPGFPDDRRVGGGTVTGPRDHLLSVDQIRLVKEARGPPTSLGRVPGSELCALVCVPDWVVRVNMKGPCKEVQKNEDQEGEAAATGPQAETLEAKKSWTANSHSALETEGTHGLGERVMADLYLESCRANSVVPVSRLLRQGSASELNLQHRGLGPQGIRALASTLTSNLYIKRLDLRDNELGGAGAEALADVLRKNSVISDVDLSENQIGAAGLQAICTALTLNPTVQKMQLQGNRLEEKAAQHLAALLLRHTGLKSLDLSYNQLNDLAGETLGPAVAENTGLTELNLSWNHLRGLGAIAFARGLEANIFLKVLDISHNGFGDSGACAVGEALRVNNVLEELNMRNNRISTSGALKLGLGLQVNQTLRVLIISKNPICSDGCVGLLKSVRSNKSSGLELLDVSGIQVSRECDELASSMSEAFPGLCIKHCTSRRKDWPQATIPAVICTKWL", "length": 474 }, "evidence": [ { "id": "A0AAA9SE66", "url": "https://omabrowser.org/oma/group/A0AAA9SE66/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RKA1-1", "protein_name": "Leucine rich repeat containing 74B", "gene_name": "LRRC74B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRDPCEGPGEKEELEEGAAATGHPAEVLEAKCSDVDSDSDLETEGTHKLGELVKDTLYLRSCQAHNVVPASCFLRQGSAPELNLRHRGLGPQGARALASSLMSNPYIKRLDLRDNGLCGAGAEALADALSKNSSISDVDLSENQLGAVGAQAVCAALVMNPAIQRVQLAGNGLEEQAAQYLAELLLANTGLKSLDLSYNQLNDQAGETLGPALAENAGLTELNMSWNHLRGSGAVAFARGLEASIFLRVLDISYNGCGDPGASAVGEALKTNNVLEELNLSNNRISALGALSLGQGLQVNRTLRILVVSRNPMRSEGCSALLKSVRANPLSAAELLDFSDIQVNREFDDLAGSLKLILPRLCIKTAAHRVEYRRELLPIFRPSK", "length": 384 }, "evidence": [ { "id": "A0AAA9SE66", "url": "https://omabrowser.org/oma/group/A0AAA9SE66/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14BP6-1", "protein_name": "Leucine-rich repeat-containing protein 74B", "gene_name": "Lrrc74b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGPCEVQKNEDQEGEAAATGPQAETLEAERSWTADSHSALEAEGTHGLGERVMATLYLKSCRANSVVPVSCLLRQEGASELNLRHRGLGPQGVRALASVLTSNPYIKRLDLRDNGLCGAGAEALADVLRKNSIISDVDLSENQIGAAGLQAICTALALNPTVEKMQLQGNRLEEQAAQHLAALLLHHRGLKSLDLSYNQLNDLAGEILGPAVAENTGLTELNLSWNHLRGLGATAFARGLEANIFLKVLDISHNGFGDSGASAIGDALRVNNVLEELNMRNNRISVSGALKLGLGLQVNQTLRILIISKNPIRSDGCVGLLKSVRNNKSSALELLDVSDIQVSRECEDLASSMSEILPGLCIKRYTSRRKDWPQASTPSQPASAPSDSGL", "length": 391 }, "evidence": [ { "id": "A0AAA9SE66", "url": "https://omabrowser.org/oma/group/A0AAA9SE66/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZQY2-1", "protein_name": "Leucine-rich repeat-containing protein 74B", "gene_name": "LRRC74B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRGSCERSGEDEEQKEEAMVACGRLSGVPEAEQGPEANWDSDLETEGTDGLGELVRDTLYLRSCRAHSVVPISCFLRQGSAQELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQALCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGPGAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSRNPMRSEGCFGLLKSVQDNPASALELLDFSDIQVNAEFDGLASSVRGILPELCIKTGACRVEYKKELLPVFRSALPASVPK", "length": 392 }, "evidence": [ { "id": "A0AAA9SE66", "url": "https://omabrowser.org/oma/group/A0AAA9SE66/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 302, "end_pos": 304 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBZ4-1", "uniprot_ac": "A0AAA9SBZ4", "uniprot_id": "A0AAA9SBZ4_BOVIN", "mass": { "chemical_mass": 14883.0, "monoisotopic_mass": 14883.0 }, "refseq": {}, "gene_names": [ { "name": "EFCAB10", "type": "recommended", "evidence": [ { "id": "A0AAA9SBZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4" } ] } ], "protein_names": [ { "name": "EF-hand calcium binding domain 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SBZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4", "locus": { "chromosome": "4", "start_pos": 46662195, "end_pos": 46685816, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053355", "url": "https://www.ensembl.org/id/ENSBTAG00000053355" } ] } } ], "crossref": [ { "id": "A0AAA9SBZ4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22976", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22976", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100296545", "url": "https://www.ncbi.nlm.nih.gov/gene/100296545", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21847", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21847", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21847:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21847:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF24548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24548", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LQN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9K3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVNKRTQEI", "length": 128, "header": "tr|A0AAA9SBZ4-1|A0AAA9SBZ4_BOVIN Isoform 1 of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0A3Q1LQN3-1", "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPGLMLKLKLQYFGHLMRRTDSLEKTLMLGKTEGGRRGQQRMRWLDERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVNKRTQEIWSAF", "length": 176, "header": "tr|A0A3Q1LQN3-1|A0AAA9SBZ4_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=2 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685023, "end_pos": 46670697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067337.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067337.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062500.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062500.2" } ] } }, { "isoform_ac": "A0AAA9S9K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9S9K3-1", "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVNKRTQEICEKTKGKDSESCQSAAEQLLLH", "length": 150, "header": "tr|A0AAA9S9K3-1|A0AAA9SBZ4_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685023, "end_pos": 46669197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124537.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124537.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082761.1" } ] } }, { "isoform_ac": "A0AAA9SBZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9SBZ4-1", "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVNKRTQEI", "length": 128, "header": "tr|A0AAA9SBZ4-1|A0AAA9SBZ4_BOVIN Isoform 1 of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685023, "end_pos": 46670707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081032.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081032.1" } ] } }, { "isoform_ac": "A0AAA9SNT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9SNT2-1", "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVPKKWTRHRRTTAVTAQ", "length": 137, "header": "tr|A0AAA9SNT2-1|A0AAA9SNT2_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685023, "end_pos": 46662567, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131390.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131390.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085606.1" } ] } }, { "isoform_ac": "A0AAA9THW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9THW7-1", "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPALKTLGLCTAEEVLKDDGHGVTFDKFRNEVNKRTQEIWSAF", "length": 77, "header": "tr|A0AAA9THW7-1|A0AAA9THW7_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685023, "end_pos": 46670697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095795.1" } ] } }, { "isoform_ac": "A0AAA9TNK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9TNK3-1", "sequence": { "sequence": "MTWCPGLSQSGARQVTGRKGRSRATATLPGRLATAQLDAMEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVNKRTQEIWSAF", "length": 171, "header": "tr|A0AAA9TNK3-1|A0AAA9TNK3_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=1 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685537, "end_pos": 46670697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100117.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100117.1" } ] } }, { "isoform_ac": "A0AAA9TXF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9TXF7-1", "sequence": { "sequence": "MEARSSRELQARNYLEKHRIMDLLTYLTSALLFFRPERPREYLISILERLRIARLSGVALPFFMDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVKTTGTIDTSKRISPLCDTAVLGQTLPVLKEATVWGR", "length": 157, "header": "tr|A0AAA9TXF7-1|A0AAA9TXF7_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46685023, "end_pos": 46667997, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102742.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102742.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101892.1" } ] } }, { "isoform_ac": "A0AAA9TXM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4/entry#A0AAA9TXM7-1", "sequence": { "sequence": "MDNSNIASMFEMLDSSNKGSISFVQYKEALKTLGLCTAEEVLKDDGHGVTFDKFRNEVCICPASLQAFARKL", "length": 72, "header": "tr|A0AAA9TXM7-1|A0AAA9TXM7_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 10 OS=Bos taurus OX=9913 GN=EFCAB10 PE=4 SV=1 CANONICAL=A0AAA9SBZ4-1" }, "locus": { "chromosome": "4", "start_pos": 46672118, "end_pos": 46669049, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117229.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117229.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102232.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102232.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TNK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNK3" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ4" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 99, "start_aa": "Met", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SCG1-1", "uniprot_ac": "A0AAA9SCG1", "uniprot_id": "A0AAA9SCG1_BOVIN", "mass": { "chemical_mass": 21397.0, "monoisotopic_mass": 21397.0 }, "refseq": {}, "gene_names": [ { "name": "BORCS8", "type": "recommended", "evidence": [ { "id": "A0AAA9SCG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1" } ] } ], "protein_names": [ { "name": "BLOC-1 related complex subunit 8", "type": "synonym", "evidence": [ { "id": "A0AAA9SCG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BORCS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1", "locus": { "chromosome": "7", "start_pos": 4082503, "end_pos": 4065383, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025817", "url": "https://www.ensembl.org/id/ENSBTAG00000025817" } ] } } ], "crossref": [ { "id": "A0AAA9SCG1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCG1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025817", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025817", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BEF6", "url": "https://www.orthodb.org/?gene=E1BEF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21146:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21146:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10167", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10167", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P301", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P301", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P301-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P301-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEF6", "url": "https://www.uniprot.org/uniprotkb/E1BEF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEF6-1", "url": "https://www.uniprot.org/uniprotkb/E1BEF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3Q8", "url": "https://www.uniprot.org/uniprotkb/G3N3Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3Q8-1", "url": "https://www.uniprot.org/uniprotkb/G3N3Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEPEMQLKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNATAQGHRSQCLVRDGHVIQREVFPEDFAGKVRKVPSSFSEKSVCRLGVQTAHVADWETAVWGEAQAFQDLCSLPQCPSHTIWPHVPS", "length": 189, "header": "tr|A0AAA9SCG1-1|A0AAA9SCG1_BOVIN Isoform 1 of BLOC-1 related complex subunit 8 OS=Bos taurus OX=9913 GN=BORCS8 PE=3 SV=1 CANONICAL=A0AAA9SCG1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1/entry#A0AAA9SCG1-1", "sequence": { "sequence": "MEEPEMQLKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNATAQGHRSQCLVRDGHVIQREVFPEDFAGKVRKVPSSFSEKSVCRLGVQTAHVADWETAVWGEAQAFQDLCSLPQCPSHTIWPHVPS", "length": 189, "header": "tr|A0AAA9SCG1-1|A0AAA9SCG1_BOVIN Isoform 1 of BLOC-1 related complex subunit 8 OS=Bos taurus OX=9913 GN=BORCS8 PE=3 SV=1 CANONICAL=A0AAA9SCG1-1" }, "locus": { "chromosome": "7", "start_pos": 4081771, "end_pos": 4065595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110971.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110971.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081561.1" } ] } }, { "isoform_ac": "A0ABI0P301-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1/entry#A0ABI0P301-1", "sequence": { "sequence": "GRGYYGRTRDAAQGEERRSPKRVRGQTVWRWQAGLCLSQGAVVSWAHPNWTVASTASLDSQTPAGSPSLTAVSWAVEWRPSLQQSLVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNATAQGHR", "length": 183, "header": "tr|A0ABI0P301-1|A0ABI0P301_BOVIN Computationally mapped isoform of BLOC-1 related complex subunit 8 OS=Bos taurus OX=9913 GN=BORCS8 PE=3 SV=1 CANONICAL=A0AAA9SCG1-1" }, "locus": { "chromosome": "7", "start_pos": 4072702, "end_pos": 4065582, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137200.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137200.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104901.1" } ] } }, { "isoform_ac": "E1BEF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1/entry#E1BEF6-1", "sequence": { "sequence": "MQTSGSGPRNRAVATMEEPEMQLKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNATAQGHSPEEPLPPSSA", "length": 134, "header": "tr|E1BEF6-1|A0AAA9SCG1_BOVIN Computationally mapped isoform of BLOC-1 related complex subunit 8 OS=Bos taurus OX=9913 GN=BORCS8 PE=3 SV=3 CANONICAL=A0AAA9SCG1-1" }, "locus": { "chromosome": "7", "start_pos": 4074350, "end_pos": 4065214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036515.7", "url": "https://www.ensembl.org/id/ENSBTAT00000036515.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036372.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036372.6" } ] } }, { "isoform_ac": "G3N3Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1/entry#G3N3Q8-1", "sequence": { "sequence": "MPGAWQLCVTFPLYLSICISLLLEPLSRVRPFGITWTVSPPGSSVRGILQAGILKWVAVPFSSFTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNATAQGHSPEEPLPPSSA", "length": 170, "header": "tr|G3N3Q8-1|G3N3Q8_BOVIN Computationally mapped isoform of BLOC-1 related complex subunit 8 OS=Bos taurus OX=9913 GN=BORCS8 PE=3 SV=1 CANONICAL=A0AAA9SCG1-1" }, "locus": { "chromosome": "7", "start_pos": 4074350, "end_pos": 4065927, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063112.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063112.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056567.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056567.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA72-1", "uniprot_ac": "A0AAA9SA72", "uniprot_id": "A0AAA9SA72_BOVIN", "mass": { "chemical_mass": 94936.0, "monoisotopic_mass": 94936.0 }, "refseq": {}, "gene_names": [ { "name": "ZCCHC14", "type": "recommended", "evidence": [ { "id": "A0AAA9SA72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72" } ] } ], "protein_names": [ { "name": "Zinc finger CCHC-type containing 14", "type": "synonym", "evidence": [ { "id": "A0AAA9SA72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZCCHC14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72", "locus": { "chromosome": "18", "start_pos": 12991195, "end_pos": 13036375, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014267", "url": "https://www.ensembl.org/id/ENSBTAG00000014267" } ] } } ], "crossref": [ { "id": "A0AAA9SA72", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014267", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014267", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09558", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09558", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528171", "url": "https://www.ncbi.nlm.nih.gov/gene/528171", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042344", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042344", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMP1", "url": "https://www.orthodb.org/?gene=A0A3Q1MMP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BM00", "url": "https://www.orthodb.org/?gene=E1BM00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16195:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16195:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25479", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25479", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26034", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26034", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MMP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMP1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BM00", "url": "https://www.uniprot.org/uniprotkb/E1BM00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BM00-1", "url": "https://www.uniprot.org/uniprotkb/E1BM00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGLCSSCLSVTPRTEPPVSSVGNSLENALHTSTHSTEGSLPKRPGGKLSRVTVEKIDLKGLSHKKNERNVECSFEVLWSDSSITSVTKSSSEVTEFISKLSQLYPEENLEKFIPCLAGPDSFYVERNHMDLEADLRYLASLPSHVLKNDHVKKFFSTSSPTQQLQSPSPGNPSLSKVGTMMGVSGRPVCGVAGIPSSQGSAQHHVQHSASAAALPHCSHSGGAGSALAYRTPMDSSPAILMPSSLQAPQTQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSEKRCLNPSAPPPVSSSGVARVPPTSHVGPVQTVRGSHAAALRVEVEQAPHQTAREGSSSECSSSSPSPMGVQAREESSDSAEENDRRVEIHLEGPDKEKPVMLLNHFTSSSARPTAQVLPVQNEAGSTPSGHHSLPPQMMTAASHIAPIRMLNSVHKAERGSTDMKLLSSSVHSLLSLEERSKVSGPRSSIKVDKSFGNTMMDVLPSSTPHQPMQVLSGLAESSSVSPTVSFGPRTKVVHASALDRVMKPAQQPALVVEASTAAAGTSSTVFHVARPPIKLLVSSSVPADSAISGQTSCSNNVQISVPPAIINPRTALYTANTKAAFSAMSSVPVGPLQGSFCANSNTAASSSHPSPSFANMATVPSCPAPSSSPALSSVPESSFYSSSGGGGGGGSSPGNLPASAQNHHHHHHHQQQPVPQQPAPAPPPGCVVCTSCGCSGSCGSSGLTVSYASYFQHPFSGPSVFPFPFLPFSPVCGSGYMGAQQYGGGAFPVVHSPYGGGVGPEPVLGGQSAFTVPPVQNFMGAAGVYQAQGLVGSSNGSSHKKSGNLSCYNCGATGHRAQDCKQPSMDFNRQGKGSRGGEIQTGVSFL", "length": 907, "header": "tr|A0AAA9SA72-1|A0AAA9SA72_BOVIN Isoform 1 of Zinc finger CCHC-type containing 14 OS=Bos taurus OX=9913 GN=ZCCHC14 PE=4 SV=1 CANONICAL=A0AAA9SA72-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72/entry#A0A3Q1MMP1-1", "sequence": { "sequence": "MVEKRCPLQRDGVYRWFSELPSPQRVEFLCGLLDLCIPLELRFLGSCLEDLARKDYHSLRDSEIKANNPADLGSLTNLTDEVVRSKLLVSLALLGSEQREAAGVLYRTLTHIDSIIHNYGLQLNEGRTGDEFLLLFTMASNHPAFSFHQKQVLRQELTQIQSSLSGGGGGPGGKSALPTCPACHKVTPRTEPPVSSVGNSLENALHTSTHSTEGSLPKRPGGKLSRVTVEKIDLKGLSHKKNERNVECSFELSQLYPEENLEKFIPCLAGPDSFYVERNHMDLEADLRYLASLPSHVLKNDHVKKFFSTSSPTQQLQSPSPGNPSLSKVGTMMGVSGRPVCGVAGIPSSQGSAQHHVQHSASAAALPHCSHSGGAGSALAYRTPMDSSPAILMPSSLQAPQTQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSEKRCLNPSAPPPVSSSGVARVPPTSHVGPVQTVRGSHAAALRVEVEQAPHQTAREGSSSECSSSSPSPMGVQAREESSDSAEENDRRVEIHLEGPDKEKPVMLLNHFTSSSARPTAQVLPVQNEAGSTPSGHHSLPPQMMTAASHIAPIRMLNSVHKAERGSTDMKLLSSSVHSLLSLEERSKVSGPRSSIKVDKSFGNTMMDVLPSSTPHQPMQVLSGLAESSSVSPTVSFGPRTKVVHASALDRVMKPAQQPALVVEASTAAAGTSSTVFHVARPPIKLLVSSSVPADSAISGQTSCSNNVQISVPPAIINPRTALYTANTKAAFSAMSSVPVGPLQGSFCANSNTAASSSHPSPSFANMATVPSCPAPSSSPALSSVPESSFYSSSGGGGGGGSSPGNLPASAQNHHHHHHHQQQPVPQQPAPAPPPGCVVCTSCGCSGSCGSSGLTVSYASYFQHPFSGPSVFPFPFLPFSPVCGSGYMGAQQYGGGAFPVVHSPYGGGVGPEPVLGGQSAFTVPPVQNFMGAAGVYQAQGLVGSSNGSSHKKSGNLSCYNCGATGHRAQDCKQPSMDFNRQGTFRLKYAPPAESLDSTD", "length": 1059, "header": "tr|A0A3Q1MMP1-1|A0AAA9SA72_BOVIN Computationally mapped isoform of Zinc finger CCHC-type containing 14 OS=Bos taurus OX=9913 GN=ZCCHC14 PE=4 SV=2 CANONICAL=A0AAA9SA72-1" }, "locus": { "chromosome": "18", "start_pos": 13036176, "end_pos": 12992199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074957.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074957.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072440.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072440.2" } ] } }, { "isoform_ac": "A0AAA9SA72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72/entry#A0AAA9SA72-1", "sequence": { "sequence": "MAAGLCSSCLSVTPRTEPPVSSVGNSLENALHTSTHSTEGSLPKRPGGKLSRVTVEKIDLKGLSHKKNERNVECSFEVLWSDSSITSVTKSSSEVTEFISKLSQLYPEENLEKFIPCLAGPDSFYVERNHMDLEADLRYLASLPSHVLKNDHVKKFFSTSSPTQQLQSPSPGNPSLSKVGTMMGVSGRPVCGVAGIPSSQGSAQHHVQHSASAAALPHCSHSGGAGSALAYRTPMDSSPAILMPSSLQAPQTQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSEKRCLNPSAPPPVSSSGVARVPPTSHVGPVQTVRGSHAAALRVEVEQAPHQTAREGSSSECSSSSPSPMGVQAREESSDSAEENDRRVEIHLEGPDKEKPVMLLNHFTSSSARPTAQVLPVQNEAGSTPSGHHSLPPQMMTAASHIAPIRMLNSVHKAERGSTDMKLLSSSVHSLLSLEERSKVSGPRSSIKVDKSFGNTMMDVLPSSTPHQPMQVLSGLAESSSVSPTVSFGPRTKVVHASALDRVMKPAQQPALVVEASTAAAGTSSTVFHVARPPIKLLVSSSVPADSAISGQTSCSNNVQISVPPAIINPRTALYTANTKAAFSAMSSVPVGPLQGSFCANSNTAASSSHPSPSFANMATVPSCPAPSSSPALSSVPESSFYSSSGGGGGGGSSPGNLPASAQNHHHHHHHQQQPVPQQPAPAPPPGCVVCTSCGCSGSCGSSGLTVSYASYFQHPFSGPSVFPFPFLPFSPVCGSGYMGAQQYGGGAFPVVHSPYGGGVGPEPVLGGQSAFTVPPVQNFMGAAGVYQAQGLVGSSNGSSHKKSGNLSCYNCGATGHRAQDCKQPSMDFNRQGKGSRGGEIQTGVSFL", "length": 907, "header": "tr|A0AAA9SA72-1|A0AAA9SA72_BOVIN Isoform 1 of Zinc finger CCHC-type containing 14 OS=Bos taurus OX=9913 GN=ZCCHC14 PE=4 SV=1 CANONICAL=A0AAA9SA72-1" }, "locus": { "chromosome": "18", "start_pos": 13027441, "end_pos": 12993231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099991.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099991.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079071.1" } ] } }, { "isoform_ac": "E1BM00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72/entry#E1BM00-1", "sequence": { "sequence": "MVEKRCPLQRDGVYRWFSELPSPQRVEFLCGLLDLCIPLELRFLGSCLEDLARKDYHSLRDSEIKANNPADLGSLTNLTDEVVRSKLLVSLALLGSEQREAAGVLYRTLTHIDSIIHNYGLQLNEGRTGDEFLLLFTMASNHPAFSFHQKQVLRQELTQIQSSLSGGGGGPGGKSALPTCPACHKVTPRTEPPVSSVGNSLENALHTSTHSTEGSLPKRPGGKLSRVTVEKIDLKGLSHKKNERNVECSFEVLWSDSSITSVTKSSSEVTEFISKLSQLYPEENLEKFIPCLAGPDSFYVERNHMDLEADLRYLASLPSHVLKNDHVKKFFSTSSPTQQLQSPSPGNPSLSKVGTMMGVSGRPVCGVAGIPSSQGSAQHHVQHSASAAALPHCSHSGGAGSALAYRTPMDSSPAILMPSSLQAPQTQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSEKRCLNPSAPPPVSSSGVARVPPTSHVGPVQTVRGSHAAALRVEVEQAPHQTAREGSSSECSSSSPSPMGVQAREESSDSAEENDRRVEIHLEGPDKEKPVMLLNHFTSSSARPTAQVLPVQNEAGSTPSGHHSLPPQMMTAASHIAPIRMLNSVHKAERGSTDMKLLSSSVHSLLSLEERSKVSGPRSSIKVDKSFGNTMMDVLPSSTPHQPMQVLSGLAESSSVSPTVSFGPRTKVVHASALDRVMKPAQQPALVVEASTAAAGTSSTVFHVARPPIKLLVSSSVPADSAISGQTSCSNNVQISVPPAIINPRTALYTANTKAAFSAMSSVPVGPLQGSFCANSNTAASSSHPSPSFANMATVPSCPAPSSSPALSSVPESSFYSSSGGGGGGGSSPGNLPASAQNHHHHHHHQQQPVPQQPAPAPPPGCVVCTSCGCSGSCGSSGLTVSYASYFQHPFSGPSVFPFPFLPFSPVCGSGYMGAQQYGGGAFPVVHSPYGGGVGPEPVLGGQSAFTVPPVQNFMGAAGVYQAQGLVGSSNGSSHKKSGNLSCYNCGATGHRAQDCKQPSMDFNRQGKGSRGGEIQTGVSFL", "length": 1081, "header": "tr|E1BM00-1|A0AAA9SA72_BOVIN Computationally mapped isoform of Zinc finger CCHC-type containing 14 OS=Bos taurus OX=9913 GN=ZCCHC14 PE=4 SV=3 CANONICAL=A0AAA9SA72-1" }, "locus": { "chromosome": "18", "start_pos": 13036176, "end_pos": 12993231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018957.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018957.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018957.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018957.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 544, "start_aa": "Thr", "end_pos": 544, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr544", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 856, "end_pos": 858, "annotation": "n_glycosylation_sequon" }, { "start_pos": 865, "end_pos": 867, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA72" }, { "id": "PS50158", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC-type", "eco_id": "ECO_0000259", "start_pos": 868, "end_pos": 883, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 544 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 856, "end_pos": 858 }, { "start_pos": 865, "end_pos": 867 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB72-1", "uniprot_ac": "A0AAA9SB72", "uniprot_id": "A0AAA9SB72_BOVIN", "mass": { "chemical_mass": 42534.0, "monoisotopic_mass": 42534.0 }, "refseq": {}, "gene_names": [ { "name": "KCNMB3", "type": "recommended", "evidence": [ { "id": "A0AAA9SB72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ] } ], "protein_names": [ { "name": "Potassium calcium-activated channel subfamily M regulatory beta subunit 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SB72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS02#function" }, { "database": "UniProtKB", "id": "RU368097", "url": "https://www.uniprot.org/uniprotkb/RU368097#function" }, { "database": "UniProtKB", "id": "F1MXB6", "url": "https://www.uniprot.org/uniprotkb/F1MXB6#function" }, { "database": "UniProtKB", "id": "A0AAA9TVH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH2#function" }, { "database": "UniProtKB", "id": "A0A3Q1MEI0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI0#function" }, { "database": "UniProtKB", "id": "A0A3Q1MS62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS62#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNMB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72", "locus": { "chromosome": "1", "start_pos": 87884590, "end_pos": 87792827, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009235", "url": "https://www.ensembl.org/id/ENSBTAG00000009235" } ] } } ], "crossref": [ { "id": "A0AAA9SB72", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009235", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009235", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539609", "url": "https://www.ncbi.nlm.nih.gov/gene/539609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CEKYSAA", "url": "https://omabrowser.org/oma/group/CEKYSAA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEI0", "url": "https://www.orthodb.org/?gene=A0A3Q1MEI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MXB6", "url": "https://www.orthodb.org/?gene=F1MXB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10258:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10258:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03185", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03185", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MEI0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS62-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T163", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T163", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T163-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T163-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXB6", "url": "https://www.uniprot.org/uniprotkb/F1MXB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXB6-1", "url": "https://www.uniprot.org/uniprotkb/F1MXB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSARGGTAFGMGEGRAIPPENEGRVSVLKAPSGLPCPLPQEAAPPALAAVRGPGRSALTLTSPRGPPGQPRRRPRRPSAGGGVAQPCPQALGGRRRRSGPGAPRRSAGRAPLPPRAPYAQPARPPAQAPRPHSPPRSAPAPHASGARREGGEVTRPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKYDQMVIFHCLFWPLLTLLGGVLIGGMVRLTQYLSFLCEKHSTAFRGEKYWQKK", "length": 390, "header": "tr|A0AAA9SB72-1|A0AAA9SB72_BOVIN Isoform 1 of Potassium calcium-activated channel subfamily M regulatory beta subunit 3 OS=Bos taurus OX=9913 GN=KCNMB3 PE=4 SV=2 CANONICAL=A0AAA9SB72-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#A0A3Q1MEI0-1", "sequence": { "sequence": "MGWPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKYDQMVIFHCLFWPLLTLLGGVLIGGMVRLTQYLSFLCEKHSTAFRGEVALHNCGFWILGFSELQMENIWEKIQKVPKSRT", "length": 264, "header": "tr|A0A3Q1MEI0-1|A0A3Q1MEI0_BOVIN Computationally mapped isoform of Calcium-activated potassium channel subunit beta OS=Bos taurus OX=9913 GN=KCNMB3 PE=3 SV=2 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87884244, "end_pos": 87865241, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076265.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076265.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069420.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069420.2" } ] } }, { "isoform_ac": "A0A3Q1MS62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#A0A3Q1MS62-1", "sequence": { "sequence": "MSHLAQERCWHAVSKSLEKNMPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKYDQMVIFHCLFWPLLTLLGGVLIGGMVRLTQYLSFLCEKHSTAFRGEHCAQQPRYATT", "length": 260, "header": "tr|A0A3Q1MS62-1|A0A3Q1MS62_BOVIN Computationally mapped isoform of Calcium-activated potassium channel subunit beta OS=Bos taurus OX=9913 GN=KCNMB3 PE=3 SV=2 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87872146, "end_pos": 87847483, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077570.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077570.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057283.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057283.2" } ] } }, { "isoform_ac": "A0AAA9SB72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#A0AAA9SB72-1", "sequence": { "sequence": "MPSARGGTAFGMGEGRAIPPENEGRVSVLKAPSGLPCPLPQEAAPPALAAVRGPGRSALTLTSPRGPPGQPRRRPRRPSAGGGVAQPCPQALGGRRRRSGPGAPRRSAGRAPLPPRAPYAQPARPPAQAPRPHSPPRSAPAPHASGARREGGEVTRPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKYDQMVIFHCLFWPLLTLLGGVLIGGMVRLTQYLSFLCEKHSTAFRGEKYWQKK", "length": 390, "header": "tr|A0AAA9SB72-1|A0AAA9SB72_BOVIN Isoform 1 of Potassium calcium-activated channel subfamily M regulatory beta subunit 3 OS=Bos taurus OX=9913 GN=KCNMB3 PE=4 SV=2 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87939807, "end_pos": 87793026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117225.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117225.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080715.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080715.2" } ] } }, { "isoform_ac": "A0AAA9SS02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#A0AAA9SS02-1", "sequence": { "sequence": "MGWPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKYDQMVIFHCLFWPLLTLLGGVLIGGMVRLTQYLSFLCEKHSTAFRGEVSGKVLHMAQHQFKLWRVGRSKGRSRETLRWWPN", "length": 265, "header": "tr|A0AAA9SS02-1|A0AAA9SB72_BOVIN Computationally mapped isoform of Potassium calcium-activated channel subfamily M regulatory beta subunit 3 OS=Bos taurus OX=9913 GN=KCNMB3 PE=4 SV=1 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87870660, "end_pos": 87865241, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085783.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085783.1" } ] } }, { "isoform_ac": "A0AAA9T163-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#A0AAA9T163-1", "sequence": { "sequence": "MATQSSILAWKIPWMEEPAYLDGLSSECKISLCCIKSAHTPQVNGRGDHPFTMGWPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKWPSTTVGSGYLASANCRWKIFGRKSRKFQKAELEFATHRQLFTQPLMILGIVSNLELTKYTGGCA", "length": 301, "header": "tr|A0AAA9T163-1|A0AAA9T163_BOVIN Computationally mapped isoform of Potassium calcium-activated channel subfamily M regulatory beta subunit 3 OS=Bos taurus OX=9913 GN=KCNMB3 PE=4 SV=1 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87884341, "end_pos": 87822876, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092539.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092539.1" } ] } }, { "isoform_ac": "A0AAA9TVH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#A0AAA9TVH2-1", "sequence": { "sequence": "MQPFSIPVQITLQGGQRRQGRPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKRDVTDCKVKQTLTVSDEHKQ", "length": 171, "header": "tr|A0AAA9TVH2-1|A0AAA9TVH2_BOVIN Computationally mapped isoform of Calcium-activated potassium channel subunit beta OS=Bos taurus OX=9913 GN=KCNMB3 PE=3 SV=1 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87873827, "end_pos": 87859818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117774.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117774.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100571.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100571.1" } ] } }, { "isoform_ac": "F1MXB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72/entry#F1MXB6-1", "sequence": { "sequence": "MQPFSIPVQITLQGGQRRQGRPAFSTSGTRRNTDHNDGDPPDVHRKLPSSAGEDRAMLLGFAMMGFSVLMFFVLGVTILKPFLLSTQREESNCTIIHVHTMDDWTDCAFTCGMDCRGQGKYPCLQLFVKLTHSGQKVLLHYNEEAVQINSKCFYTPKCHQHRNDLLSGALDIKEFFDHKNGTPFSCFYSPDSQSEDVILIKKYDQMVIFHCLFWPLLTLLGGVLIGGMVRLTQYLSFLCEKHSTAFRGEVSGKVLHMAQHQFKLWRVGRSKGRSRETLRWWPN", "length": 283, "header": "tr|F1MXB6-1|F1MXB6_BOVIN Computationally mapped isoform of Calcium-activated potassium channel subunit beta OS=Bos taurus OX=9913 GN=KCNMB3 PE=3 SV=2 CANONICAL=A0AAA9SB72-1" }, "locus": { "chromosome": "1", "start_pos": 87870660, "end_pos": 87859818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045571.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045571.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042950.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042950.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539609", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IRB9-1", "protein_name": "Calcium-activated potassium channel subunit beta-3 isoform X1", "gene_name": "kcnmb3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLLNQSPRGSFSVPVNITLQGARRRHMRDVIHHQAQLHDSGGNWRKERELKCNEKARAQIPDSSVGEDRAVLLGFLMMTCSILMYLMVGILMVKPCIHSDWISSVNCSLVHIDLSDEVMDCRGIVNFKCLRALVNITTSNKTSSLQLYYDEDAVNSRLKTNSFSQCFYTPKCQRNKTEQETEARNIKQALITQRENLTCFLSPSHPEDAICRRKYNLEMALYYLLWPSLMLFGGIVLVGLVKLNQHLALLCSEISRDEFLDNQSNQAEGRIYQLLKCRSGETAEQHKPLS", "length": 290 }, "evidence": [ { "id": "A0AAA9SB72", "url": "https://omabrowser.org/oma/group/A0AAA9SB72/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A7VL23-1", "protein_name": "Calcium-activated potassium channel subunit beta-3", "gene_name": "Kcnmb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQPFSIPVQITLQGGRRRQGRTALPASGISNGDPLKVHPKLPSSAGEDRATLLGIAMMASSVLMFFLLGTTVLKPFMLSSPREESNCTTVHTHIADDWLDFAFTCEGSCQGQGTYPCLQVFVNLSHSGQKVLLHYDEEAIRTNPKCFYTPKCHGDRDHLLNSALDIKEFFDHNNGTFPCFYSPDGPLGVVLRKSGHKVVFHCLFWPLLTLLGGALIVGLVRLTQHLSFQCEKYRAVVRA", "length": 239 }, "evidence": [ { "id": "A0AAA9SB72", "url": "https://omabrowser.org/oma/group/A0AAA9SB72/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q7U0-1", "protein_name": "Calcium-activated potassium channel subunit beta", "gene_name": "Kcnmb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQPFSIPVQITLQGGRRRQGRTALPASGKINGDPLKVHPKLPSSAGEDRAMLLGVAMMASSVLMFFLLGTTVLKPFMLRSPREESNCTTVHTHIVDDGLDFSFTCEGSCQDHGRSPCLQVFVNLSHSGQKVLLHYDDEAIRTNPKCFYTPKCHGDRDDLLNSVLDIKEFFDHNNGTFPCFYSPDGPLGVVLRKSGHKVVFHCLFWPLLTLLGGALIVGLVRLTQHLSFQCEQYSTVVRA", "length": 239 }, "evidence": [ { "id": "A0AAA9SB72", "url": "https://omabrowser.org/oma/group/A0AAA9SB72/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPA1-1", "protein_name": "Calcium-activated potassium channel subunit beta-3", "gene_name": "KCNMB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS", "length": 279 }, "evidence": [ { "id": "A0AAA9SB72", "url": "https://omabrowser.org/oma/group/A0AAA9SB72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "potassium channel regulator activity", "id": "GO:0015459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ], "pmid": "" }, { "name": "calcium-activated potassium channel activity", "id": "GO:0015269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015269", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of calcium ion", "id": "GO:0005513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 315, "end_pos": 317 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAH4-1", "uniprot_ac": "A0AAA9SAH4", "uniprot_id": "A0AAA9SAH4_BOVIN", "mass": { "chemical_mass": 60929.0, "monoisotopic_mass": 60929.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC181", "type": "recommended", "evidence": [ { "id": "A0AAA9SAH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 181", "type": "recommended", "evidence": [ { "id": "A0AAA9SAH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Microtubule-binding protein that is essential for the integrity and function of the manchette, facilitating proper sperm head shaping and subsequent flagellum formation during spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4#function" }, { "database": "UniProtKB", "id": "ARBA00094222", "url": "https://www.uniprot.org/uniprotkb/ARBA00094222#function" }, { "database": "UniProtKB", "id": "A0AAA9SCG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG9#function" }, { "database": "UniProtKB", "id": "A0AAA9TB82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB82#function" }, { "database": "UniProtKB", "id": "F1MKX2", "url": "https://www.uniprot.org/uniprotkb/F1MKX2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC181", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4", "locus": { "chromosome": "16", "start_pos": 37060066, "end_pos": 37082749, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020264", "url": "https://www.ensembl.org/id/ENSBTAG00000020264" } ] } } ], "crossref": [ { "id": "A0AAA9SAH4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020264", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020264", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540268", "url": "https://www.ncbi.nlm.nih.gov/gene/540268", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MKX2", "url": "https://www.orthodb.org/?gene=F1MKX2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14320", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14320", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14320:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14320:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKX2", "url": "https://www.uniprot.org/uniprotkb/F1MKX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKX2-1", "url": "https://www.uniprot.org/uniprotkb/F1MKX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDRETRRCHGSRVLAAAAQVLGFPLPHCQSLKRGEAHAPGHLCDSSRCVFTQMACGNEENINQDLKENETEIEHTKQLSDPDKSLKDEVSLRRNDFISVPSIQPLDPISDSDSENSLQESKLESHQDLEEEEDEELRRYIMEKIIQANRLLQNQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTYKNYFANESNVSGKLSQLCISNEFRQENVILSLTDGNCEENKDRKILMERDGKFELVNLQDIKSQGVLPPINNANSTEGEPQQLSPRSPNSSVSGVKKEEPVAKVHALAPSSTEEPLTYIPQPPPNPKTYPSSAVNSDRSKGNGKSNQRTQSADVSPATSTFCLSPRQKELKKRLEQKREKLKKEEDQKKIEEEKEKKKENDMVFKAWLQKKREQVLEMRRIQRAKQIEDMNSRQENRDPQQAFRLWLKKKHEEQLKERKTEELRKQEECLVFLKGTEGRDRAFKQWLRRKQIEKLAEQQAVKERARQLRLEAKRSKQLQCHLYNMSEAKSFRFTDHYN", "length": 524, "header": "tr|A0AAA9SAH4-1|A0AAA9SAH4_BOVIN Isoform 1 of Coiled-coil domain-containing protein 181 OS=Bos taurus OX=9913 GN=CCDC181 PE=3 SV=1 CANONICAL=A0AAA9SAH4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4/entry#A0AAA9SAH4-1", "sequence": { "sequence": "MKDRETRRCHGSRVLAAAAQVLGFPLPHCQSLKRGEAHAPGHLCDSSRCVFTQMACGNEENINQDLKENETEIEHTKQLSDPDKSLKDEVSLRRNDFISVPSIQPLDPISDSDSENSLQESKLESHQDLEEEEDEELRRYIMEKIIQANRLLQNQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTYKNYFANESNVSGKLSQLCISNEFRQENVILSLTDGNCEENKDRKILMERDGKFELVNLQDIKSQGVLPPINNANSTEGEPQQLSPRSPNSSVSGVKKEEPVAKVHALAPSSTEEPLTYIPQPPPNPKTYPSSAVNSDRSKGNGKSNQRTQSADVSPATSTFCLSPRQKELKKRLEQKREKLKKEEDQKKIEEEKEKKKENDMVFKAWLQKKREQVLEMRRIQRAKQIEDMNSRQENRDPQQAFRLWLKKKHEEQLKERKTEELRKQEECLVFLKGTEGRDRAFKQWLRRKQIEKLAEQQAVKERARQLRLEAKRSKQLQCHLYNMSEAKSFRFTDHYN", "length": 524, "header": "tr|A0AAA9SAH4-1|A0AAA9SAH4_BOVIN Isoform 1 of Coiled-coil domain-containing protein 181 OS=Bos taurus OX=9913 GN=CCDC181 PE=3 SV=1 CANONICAL=A0AAA9SAH4-1" }, "locus": { "chromosome": "16", "start_pos": 37082550, "end_pos": 37060182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131666.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131666.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080442.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080442.1" } ] } }, { "isoform_ac": "A0AAA9SCG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4/entry#A0AAA9SCG9-1", "sequence": { "sequence": "MNENKDTDSKDSGEYEDDFEKDLEWLINEKEKSGASIMEMACGNEENINQDLKENETEIEHTKQLSDPDKSLKDEVSLRRNDFISVPSIQPLDPISDSDSENSLQESKLESHQDLEEEEDEELRRYIMEKIIQANRLLQNQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTYKNYFANESNVSGKLSQLCISNEFRQENVILSLTDGNCEENKDRKILMERDGKFELVNLQDIKSQGVLPPINNANSTEGEPQQLSPRSPNSSVSGVKKEEPVAKVHALAPSSTEEPLTYIPQPPPNPKTYPSSAVNSDRSKGNGKSNQRTQSADVSPATSTFCLSPRQKELKKRLEQKREKLKKEEDQKKIEEEKEKKKENDMVFKAWLQKKREQVLEMRRIQRAKQIEDMNSRFLSHVRLFATSWTLAHQAPLSMGILQEKKLELVAMPSSRGSSRPRDGIQVLLHCRWILYQLSHQGSPRILEWIAYPFSRGLSDPVFEPGSLGLPAVQILILVYYVCKYVFLD", "length": 517, "header": "tr|A0AAA9SCG9-1|A0AAA9SCG9_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 181 OS=Bos taurus OX=9913 GN=CCDC181 PE=3 SV=1 CANONICAL=A0AAA9SAH4-1" }, "locus": { "chromosome": "16", "start_pos": 37075789, "end_pos": 37065579, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128393.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128393.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081229.1" } ] } }, { "isoform_ac": "A0AAA9TB82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4/entry#A0AAA9TB82-1", "sequence": { "sequence": "MNENKDTDSKDSGEYEDDFEKDLEWLINEKEKSGASIMEMACGNEENINQDLKENETEIEHTKQLSDPDKSLKDEVSLRRNDFISVPSIQPLDPISDSDSENSLQESKLESHQDLEEEEDEELRRYIMEKIIQANRLLQNQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTYKNYFANESNVSGKLSQLCISNEFRQENVILSLTDGNCEENKDRKILMERDGKFELVNLQDIKSQGVLPPINNANSTEGEPQQLSPRSPNSSVSGVKKEEPVAKVHALAPSSTEEPLTYIPQPPPNPKTYPSSAVNSDRSKGNGKSNQRTQSADVSPATSTFCLSPRQKELKKRLEQKREKLKKEIKNCGSGIQNGAGWPLWIWFQMCSCITENLNFLNCVKLKYITRPLQNTICQLQPDGLKVSPCSYLTISDTSQSLLKKHRYFLLASILILTNNSVICTFCLYICLPYFVMPWNTIQMLLEFVSPGQ", "length": 481, "header": "tr|A0AAA9TB82-1|A0AAA9SAH4_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 181 OS=Bos taurus OX=9913 GN=CCDC181 PE=3 SV=1 CANONICAL=A0AAA9SAH4-1" }, "locus": { "chromosome": "16", "start_pos": 37075789, "end_pos": 37070390, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094831.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094831.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093334.1" } ] } }, { "isoform_ac": "F1MKX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4/entry#F1MKX2-1", "sequence": { "sequence": "MSGLSLFFNKQKMNENKDTDSKDSGEYEDDFEKDLEWLINEKEKSGASIMEMACGNEENINQDLKENETEIEHTKQLSDPDKSLKDEVSLRRNDFISVPSIQPLDPISDSDSENSLQESKLESHQDLEEEEDEELRRYIMEKIIQANRLLQNQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTYKNYFANESNVSGKLSQLCISNEFRQENVILSLTDGNCEENKDRKILMERDGKFELVNLQDIKSQGVLPPINNANSTEGEPQQLSPRSPNSSVSGVKKEEPVAKVHALAPSSTEEPLTYIPQPPPNPKTYPSSAVNSDRSKGNGKSNQRTQSADVSPATSTFCLSPRQKELKKRLEQKREKLKKEEDQKKIEEEKEKKKENDMVFKAWLQKKREQVLEMRRIQRAKQIEDMNSRQENRDPQQAFRLWLKKKHEEQLKERKTEELRKQEECLVFLKGTEGRDRAFKQWLRRKQIEKLAEQQAVKERARQLRLEAKRSKQLQCHLYNMSEAKSFRFTDHYN", "length": 522, "header": "tr|F1MKX2-1|F1MKX2_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 181 OS=Bos taurus OX=9913 GN=CCDC181 PE=3 SV=4 CANONICAL=A0AAA9SAH4-1" }, "locus": { "chromosome": "16", "start_pos": 37076122, "end_pos": 37060182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027004.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027004.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027004.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027004.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "manchette assembly", "id": "GO:1905198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" }, { "name": "sperm flagellum assembly", "id": "GO:0120316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120316", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 192, "end_pos": 194 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDW3-1", "uniprot_ac": "A0AAA9SDW3", "uniprot_id": "A0AAA9SDW3_BOVIN", "mass": { "chemical_mass": 27668.0, "monoisotopic_mass": 27668.0 }, "refseq": {}, "gene_names": [ { "name": "COA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SDW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3" } ] } ], "protein_names": [ { "name": "Cytochrome c oxidase assembly factor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SDW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3", "locus": { "chromosome": "4", "start_pos": 77465906, "end_pos": 77370974, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012968", "url": "https://www.ensembl.org/id/ENSBTAG00000012968" } ] } } ], "crossref": [ { "id": "A0AAA9SDW3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012968", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012968", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505736", "url": "https://www.ncbi.nlm.nih.gov/gene/505736", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR014807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47148", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47148", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47148:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47148:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08695", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08695", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRY0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRY0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NL33", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NL33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NL33-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NL33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLSRAPGGECNHGSLKVEEGNRKNQRESHVRRTKPPLKMEEGTVSQGRWMTSTRWKVKERNSSVKLPEKCPGASLLDSGVLQKLPSWAAFLRWFSRKLGYEVAKSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 245, "header": "tr|A0AAA9SDW3-1|A0AAA9SDW3_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=1 CANONICAL=A0AAA9SDW3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0A3Q1LRY0-1", "sequence": { "sequence": "MCPGASLLDSGVLQKLPSWAAFLRWFSRKLGYEVAKSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 176, "header": "tr|A0A3Q1LRY0-1|A0AAA9SDW3_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=1 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77403976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112545.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112545.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097451.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097451.1" } ] } }, { "isoform_ac": "A0A3Q1MBM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0A3Q1MBM6-1", "sequence": { "sequence": "MESQRKKFFCKAPRKVSWSFSAGLRSSTKAAFLWKDHGLQGQTDGRHCSAMEELRDSKLSSGDSDVQRLRLHRETASLLPAQSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 222, "header": "tr|A0A3Q1MBM6-1|A0AAA9SDW3_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=2 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77410761, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084872.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084872.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068129.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068129.2" } ] } }, { "isoform_ac": "A0A3Q1NL33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0A3Q1NL33-1", "sequence": { "sequence": "MSWSFSAGLRSSTKAAFLSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 158, "header": "tr|A0A3Q1NL33-1|A0AAA9SDW3_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=2 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77394737, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069965.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069965.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073092.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073092.2" } ] } }, { "isoform_ac": "A0AAA9S1S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0AAA9S1S3-1", "sequence": { "sequence": "PLEEVTSEVSTAPRGACPPAGVCPTHPHTLHFRKGLSRSLWLGVSTPDRLTSTREKRVGVLELLCWTPEFYKSCLLETFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 183, "header": "tr|A0AAA9S1S3-1|A0AAA9SDW3_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=1 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77371173, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102777.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102777.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079822.1" } ] } }, { "isoform_ac": "A0AAA9SDW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0AAA9SDW3-1", "sequence": { "sequence": "MLLSRAPGGECNHGSLKVEEGNRKNQRESHVRRTKPPLKMEEGTVSQGRWMTSTRWKVKERNSSVKLPEKCPGASLLDSGVLQKLPSWAAFLRWFSRKLGYEVAKSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 245, "header": "tr|A0AAA9SDW3-1|A0AAA9SDW3_BOVIN Isoform 1 of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=1 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77395040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124605.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124605.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081998.1" } ] } }, { "isoform_ac": "A0AAA9SLE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0AAA9SLE4-1", "sequence": { "sequence": "MLLSRAPGGECPGASLLDSGVLQKLPSWAAFLRWFSRKLGYEVAKSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 185, "header": "tr|A0AAA9SLE4-1|A0AAA9SLE4_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=1 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77395040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129068.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129068.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086074.1" } ] } }, { "isoform_ac": "A0AAA9SS78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3/entry#A0AAA9SS78-1", "sequence": { "sequence": "MESQRKKFFCKAPRKVSWSFSAGLRSSTKAAFLSLGSRMSMPLGKQVFFAGVAASGSCAILYYLVQKTFSRASYYQLALEQLHSHPEALEALGTPLNVHYLRLTDKYNFVDIADAKLKIPVSGPKSEGHLYVSSSRDAPFKRWNLQEVFLELKDGQQIPLFKPSRDNDEVKKE", "length": 173, "header": "tr|A0AAA9SS78-1|A0AAA9SS78_BOVIN Computationally mapped isoform of Cytochrome c oxidase assembly factor 1 OS=Bos taurus OX=9913 GN=COA1 PE=4 SV=1 CANONICAL=A0AAA9SDW3-1" }, "locus": { "chromosome": "4", "start_pos": 77465637, "end_pos": 77410761, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127301.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127301.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086962.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086962.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE11-1", "uniprot_ac": "A0AAA9SE11", "uniprot_id": "A0AAA9SE11_BOVIN", "mass": { "chemical_mass": 28329.0, "monoisotopic_mass": 28329.0 }, "refseq": {}, "gene_names": [ { "name": "PLEKHB2", "type": "recommended", "evidence": [ { "id": "A0AAA9SE11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain containing B2", "type": "synonym", "evidence": [ { "id": "A0AAA9SE11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11", "locus": { "chromosome": "2", "start_pos": 1969794, "end_pos": 1920611, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000941", "url": "https://www.ensembl.org/id/ENSBTAG00000000941" } ] } } ], "crossref": [ { "id": "A0AAA9SE11", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE11", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000941", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000941", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUK3", "url": "https://www.orthodb.org/?gene=A0A3Q1LUK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14309", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14309", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14309:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14309:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LUK3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFVKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDAQTRQSVEDKVHMPVDCINIRMGRECRDIQPPDGKPKDCMLQIVCRDGKTISLCAESTDDCLLSTTGPPGPPSPSNLWIHPHQRFARCTLRMRAWKFTLQDSRTNTAYVGSEVMYDETAVASSPPPYTAYAAPTPEQAYGYGPYSGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRERYRDNDSDLALGMLAGAATGMALGSLFWVF", "length": 253, "header": "tr|A0AAA9SE11-1|A0AAA9SE11_BOVIN Isoform 1 of Pleckstrin homology domain containing B2 OS=Bos taurus OX=9913 GN=PLEKHB2 PE=4 SV=1 CANONICAL=A0AAA9SE11-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11/entry#A0A3Q1LUK3-1", "sequence": { "sequence": "MAFVKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDAQTRQSVEDKVHMPVDCINIRMGRECRDIQPPDGKPKDCMLQIVCRDGKTISLCAESTDDCLAWKFTLQDSRTNTAYVGSEVMYDETAVASSPPPYTAYAAPTPEGFMDSSLPTKSSFVSGTETTTATWRWACWPEQPQAWPWGLCSGSSRVCGTSACIASDTPCAII", "length": 204, "header": "tr|A0A3Q1LUK3-1|A0AAA9SE11_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing B2 OS=Bos taurus OX=9913 GN=PLEKHB2 PE=4 SV=1 CANONICAL=A0AAA9SE11-1" }, "locus": { "chromosome": "2", "start_pos": 1967183, "end_pos": 1936228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077157.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077157.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060820.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060820.1" } ] } }, { "isoform_ac": "A0AAA9SE11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11/entry#A0AAA9SE11-1", "sequence": { "sequence": "MAFVKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDAQTRQSVEDKVHMPVDCINIRMGRECRDIQPPDGKPKDCMLQIVCRDGKTISLCAESTDDCLLSTTGPPGPPSPSNLWIHPHQRFARCTLRMRAWKFTLQDSRTNTAYVGSEVMYDETAVASSPPPYTAYAAPTPEQAYGYGPYSGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRERYRDNDSDLALGMLAGAATGMALGSLFWVF", "length": 253, "header": "tr|A0AAA9SE11-1|A0AAA9SE11_BOVIN Isoform 1 of Pleckstrin homology domain containing B2 OS=Bos taurus OX=9913 GN=PLEKHB2 PE=4 SV=1 CANONICAL=A0AAA9SE11-1" }, "locus": { "chromosome": "2", "start_pos": 1967128, "end_pos": 1936228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115318.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115318.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081828.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081828.1" } ] } }, { "isoform_ac": "A0AAA9TJ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11/entry#A0AAA9TJ46-1", "sequence": { "sequence": "MAFVKSGWLLRQSTILKRWKKNWFDLWSDGHLIYYDAQTRQSVEDKVHMPVDCINIRMGRECRDIQPPDGKPKDCMLQIVCRDGKTISLCAESTDDCFRRMAMVHTVVHTHQELKLSMLQMDRLMLYPISTRMQGFMDSSLPTKSSFVSGTETTTATWRWACWPEQPQAWPWGLCSGSSRVCGTSACIASDTPCAII", "length": 197, "header": "tr|A0AAA9TJ46-1|A0AAA9TJ46_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing B2 OS=Bos taurus OX=9913 GN=PLEKHB2 PE=4 SV=1 CANONICAL=A0AAA9SE11-1" }, "locus": { "chromosome": "2", "start_pos": 1967183, "end_pos": 1936228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092874.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092874.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097187.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 170, "start_aa": "Thr", "end_pos": 170, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr170", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SE11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE11" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 123, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 170 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 228, "end_pos": 230 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDG4-1", "uniprot_ac": "A0AAA9SDG4", "uniprot_id": "A0AAA9SDG4_BOVIN", "mass": { "chemical_mass": 104909.0, "monoisotopic_mass": 104909.0 }, "refseq": {}, "gene_names": [ { "name": "DDHD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4" } ] } ], "protein_names": [ { "name": "DDHD domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDHD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4", "locus": { "chromosome": "10", "start_pos": 65675250, "end_pos": 65741132, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019924", "url": "https://www.ensembl.org/id/ENSBTAG00000019924" } ] } } ], "crossref": [ { "id": "A0AAA9SDG4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019924", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019924", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "338047", "url": "https://www.ncbi.nlm.nih.gov/gene/338047", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:338047", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338047", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DNKKSWW", "url": "https://omabrowser.org/oma/group/DNKKSWW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV01", "url": "https://www.orthodb.org/?gene=A0A3Q1LV01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVM4", "url": "https://www.orthodb.org/?gene=A0A3Q1LVM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMR4", "url": "https://www.orthodb.org/?gene=A0A3Q1MMR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1C0", "url": "https://www.orthodb.org/?gene=F1N1C0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N1K0", "url": "https://www.orthodb.org/?gene=G3N1K0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23509", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23509", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23509:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23509:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02862", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02862", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LV01", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV01-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMR4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C0", "url": "https://www.uniprot.org/uniprotkb/F1N1C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1C0-1", "url": "https://www.uniprot.org/uniprotkb/F1N1C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1K0", "url": "https://www.uniprot.org/uniprotkb/G3N1K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1K0-1", "url": "https://www.uniprot.org/uniprotkb/G3N1K0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDVVYHLPPFSLPSLFKWRGYKESTDAAGLKRKRSQAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVIQNKDNTLVELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 937, "header": "tr|A0AAA9SDG4-1|A0AAA9SDG4_BOVIN Isoform 1 of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=1 CANONICAL=A0AAA9SDG4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0A3Q1LV01-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDVVYHLPPFSLPSLFKWRGYKESTDAAGLKRKRSQAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 909, "header": "tr|A0A3Q1LV01-1|A0AAA9SDG4_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=1 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65677424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083152.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083152.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061006.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061006.1" } ] } }, { "isoform_ac": "A0A3Q1LVM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0A3Q1LVM4-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 875, "header": "tr|A0A3Q1LVM4-1|A0AAA9SDG4_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=2 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65677424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073715.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073715.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059371.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059371.2" } ] } }, { "isoform_ac": "A0A3Q1MMR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0A3Q1MMR4-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDGSGISYSAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 882, "header": "tr|A0A3Q1MMR4-1|A0AAA9SDG4_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=2 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65677424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085985.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085985.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070741.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070741.2" } ] } }, { "isoform_ac": "A0AAA9S0Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0AAA9S0Q2-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSACLTSPVHKRTLY", "length": 827, "header": "tr|A0AAA9S0Q2-1|A0AAA9SDG4_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=1 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65680347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104494.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104494.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078552.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078552.1" } ] } }, { "isoform_ac": "A0AAA9S3C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0AAA9S3C3-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVIQNKDNTLGLTSPVHKRTLY", "length": 855, "header": "tr|A0AAA9S3C3-1|A0AAA9SDG4_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=1 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65680347, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079602.1" } ] } }, { "isoform_ac": "A0AAA9SDG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0AAA9SDG4-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDVVYHLPPFSLPSLFKWRGYKESTDAAGLKRKRSQAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVIQNKDNTLVELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 937, "header": "tr|A0AAA9SDG4-1|A0AAA9SDG4_BOVIN Isoform 1 of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=1 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65677424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123560.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123560.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084177.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084177.1" } ] } }, { "isoform_ac": "A0AAA9TL32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#A0AAA9TL32-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRSPFFKFRVTLSFQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 835, "header": "tr|A0AAA9TL32-1|A0AAA9TL32_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=1 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65677424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110513.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110513.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099131.1" } ] } }, { "isoform_ac": "F1N1C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#F1N1C0-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSACDSGFLLAHIDCLSSSR", "length": 832, "header": "tr|F1N1C0-1|A0AAA9SDG4_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=4 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65683190, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026549.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026549.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026549.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026549.7" } ] } }, { "isoform_ac": "G3N1K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4/entry#G3N1K0-1", "sequence": { "sequence": "MNYPGHGSPRSSERNGGRGGDGAAWELGSDTEPAFGGSVCRFDHLPVGEPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDDNYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPLVPSNSGGGGAAGGGPGERKRTRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQATGARARAQDPDGDHVCGPASPAGPASSSVEDEDEDRVCGFCSRIAGHGREMEELVNIERVCVRGGLYEVDVTQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSRFRGQQMQESFDIEVSKPIDGKDASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPNFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEYMKPSFLHPAKDPTSISENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSETSRDSIEDEKKPVASPPMTTVATQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDNNVKPSLDPV", "length": 832, "header": "tr|G3N1K0-1|G3N1K0_BOVIN Computationally mapped isoform of DDHD domain containing 1 OS=Bos taurus OX=9913 GN=DDHD1 PE=3 SV=3 CANONICAL=A0AAA9SDG4-1" }, "locus": { "chromosome": "10", "start_pos": 65740945, "end_pos": 65677424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065952.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065952.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055746.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055746.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:338047", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338047", "resource": "KEGG Pathway" }, { "id": "R-BTA-1483166", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "resource": "Reactome", "description": "Synthesis of PA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R7G4-1", "protein_name": "DDHD domain containing 1", "gene_name": "DDHD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNYPGRGSQLSPEHNGRGGGGASWELGSDAEPAFGSSVRCFDHLTAGDPGDDEVPLALLRGEPGLHLAPGAEDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSSSLHPPQQPPLVPSNSGGGGAAGGGPGERKRIRPGGAAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQAADARAQAQDPEGDHAVGPPSATGQASGSLEDHEGDRVCGFCPRITGHGREMEELVNIERVCVRGGLYEVDVNQGECYPVYWNQSDKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLSCFRGQQMQESFDIDVSKPIDGKNAIHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLDDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYVTKRRLREIEERLHGLKASSVTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYECMKPSFLHPAKEPTSVSENEGISTVPSPVTSPVLARRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTSQPSETRDAVEDEKKPVTSPPTTTVAVQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVMQNKDNTLGELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHDKHDNNAKPNLDPI", "length": 903 }, "evidence": [ { "id": "A0AAA9SDG4", "url": "https://omabrowser.org/oma/group/A0AAA9SDG4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80YA3-1", "protein_name": "Phospholipase DDHD1", "gene_name": "Ddhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTSHIVFVVHGIGQKMDQGRIIKNTAMMREAARKMEEKHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMMGWNPGGLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEDRLHGLKAPSISQTPALKFKVENFFCMGSPLAVFLALRGIRPGNSGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPNFLNPAKEPTSVSDSENIAAIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSEPSKDSLEDDKKPSASPSTTTVATQTLPHSGSGFLDSAYFRLQESFFYLPQLLFPENVMQSKDDSLVELEHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDTEAKPSLGSL", "length": 547 }, "evidence": [ { "id": "A0AAA9SDG4", "url": "https://omabrowser.org/oma/group/A0AAA9SDG4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NEL9-1", "protein_name": "Phospholipase DDHD1", "gene_name": "DDHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNYPGRGSPRSPEHNGRGGGGGAWELGSDARPAFGGGVCCFEHLPGGDPDDGDVPLALLRGEPGLHLAPGTDDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSLSLHPPQQPPLVPTNSGGGGATGGSPGERKRTRLGGPAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQTTGARPQGGDRDGDHVCSPTGPASSSGEDDDEDRACGFCQSTTGHEPEMVELVNIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLNCFRGQQMQENFDIEVSKSIDGKDAVHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLKEIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPSFLNPAKEPTSVSENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTTQSSETSKDSMEDEKKPVASPSATTVGTQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVMQNKDNALVELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDDDAKPNLDPI", "length": 900 }, "evidence": [ { "id": "A0AAA9SDG4", "url": "https://omabrowser.org/oma/group/A0AAA9SDG4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4" } ], "pmid": "" }, { "name": "phospholipase activity", "id": "GO:0004620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004620", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 715, "end_pos": 717, "annotation": "n_glycosylation_sequon" }, { "start_pos": 725, "end_pos": 727, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDG4" }, { "id": "PS51043", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DDHD", "eco_id": "ECO_0000259", "start_pos": 648, "end_pos": 923, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 282, "end_pos": 284 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 715, "end_pos": 717 }, { "start_pos": 725, "end_pos": 727 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBQ8-1", "uniprot_ac": "A0AAA9SBQ8", "uniprot_id": "A0AAA9SBQ8_BOVIN", "mass": { "chemical_mass": 219822.0, "monoisotopic_mass": 219822.0 }, "refseq": {}, "gene_names": [ { "name": "EML5", "type": "recommended", "evidence": [ { "id": "A0AAA9SBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" } ] } ], "protein_names": [ { "name": "EMAP like 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EML5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8", "locus": { "chromosome": "10", "start_pos": 100301923, "end_pos": 100460203, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009994", "url": "https://www.ensembl.org/id/ENSBTAG00000009994" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "537305", "url": "https://www.ncbi.nlm.nih.gov/gene/537305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AVAPCLE", "url": "https://omabrowser.org/oma/group/AVAPCLE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWI2", "url": "https://www.orthodb.org/?gene=A0A3Q1LWI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7B8", "url": "https://www.orthodb.org/?gene=F1N7B8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13720:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13720:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03451", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03451", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23409", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23409", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LWI2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWI2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7B8", "url": "https://www.uniprot.org/uniprotkb/F1N7B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7B8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7B8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERALVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDGEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPVRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDVYGVAQRYKKLGECVGSLSFITHLDWSSDSRYLQTNDGNGKRLLYRMPGGKEVASKEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIVKLFRYPCLRKGAKFKKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLADSNSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQYKEKQKSGTSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLALHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGYHQYGVCAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYMGTLGKSDTMMCAVYGRTEDMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHVDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSGEAEKIGWASWTSVLGFCCEAIWPVIGEVTDVTASCLTSDKTVLATGDDLGFVKLFRYPAKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGIKPHLQQKEPSTDERQTFVGKVMPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELVFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAVNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRAGHNQRIFVAEFRPDSDSQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKEKPSKEGGAVKLWDQELRRCRAFRLETGQASDCVRSVCRGKGKILVGTRSAEIIEVGEKNAVCSVLVSGHVDGPVWGLATHPSRDFFLSAAEDGTVRLWDIADRKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRFLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADGRHLQVSTGCYKRHVYEVPSGKHLMDQAAIDRITWATWTSILGDEVMGIWSRHAEKADVSCACVSRSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVANIRFTSGDRHVVSAGGDDCSLFVWKCVHMPH", "length": 1977, "header": "tr|A0AAA9SBQ8-1|A0AAA9SBQ8_BOVIN Isoform 1 of EMAP like 5 OS=Bos taurus OX=9913 GN=EML5 PE=3 SV=1 CANONICAL=A0AAA9SBQ8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8/entry#A0A3Q1LWI2-1", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERALVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDGEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPVRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDVYGVAQRYKKLGECVGSLSFITHLDWSSDSRYLQTNDGNGKRLLYRMPGGKEVASKEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIVKLFRYPCLRKGAKFKKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLADSNSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQYKEKQKSGTSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLALHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGYHQYGVCAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYMGTLGKSDTMMCAVYGRTEDMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHVDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSGEAEKIGWASWTSVLGFCCEAIWPVIGEVTDVTASCLTSDKTVLATGDDLGFVKLFRYPAKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGIKPHLQQKEPSTDERPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELVFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVATAPSIHIWDAVNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRAGHNQRIFVAEFRPDSDSQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKEKPSKEGGAVKLWDQELRRCRAFRLETGQASDCVRSVCRGKGKILVGTRSAEIIEVGEKNAVCSVLVSGHVDGPVWGLATHPSRDFFLSAAEDGTVRLWDIADRKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRFLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADGRHLQVSTGCYKRHVYEVPSGKHLMDQAAIDRITWATWTSILGDEVMGIWSRHAEKADVSCACVSRSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVANIRFTSGDRHVVSAGGDDCSLFVWKCVHMPH", "length": 1962, "header": "tr|A0A3Q1LWI2-1|A0AAA9SBQ8_BOVIN Computationally mapped isoform of EMAP like 5 OS=Bos taurus OX=9913 GN=EML5 PE=3 SV=1 CANONICAL=A0AAA9SBQ8-1" }, "locus": { "chromosome": "10", "start_pos": 100460004, "end_pos": 100303443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065054.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065054.1" } ] } }, { "isoform_ac": "A0AAA9SBQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8/entry#A0AAA9SBQ8-1", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERALVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDGEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPVRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDVYGVAQRYKKLGECVGSLSFITHLDWSSDSRYLQTNDGNGKRLLYRMPGGKEVASKEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIVKLFRYPCLRKGAKFKKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLADSNSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQYKEKQKSGTSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLALHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGYHQYGVCAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYMGTLGKSDTMMCAVYGRTEDMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHVDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSGEAEKIGWASWTSVLGFCCEAIWPVIGEVTDVTASCLTSDKTVLATGDDLGFVKLFRYPAKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGIKPHLQQKEPSTDERQTFVGKVMPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELVFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAVNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRAGHNQRIFVAEFRPDSDSQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKEKPSKEGGAVKLWDQELRRCRAFRLETGQASDCVRSVCRGKGKILVGTRSAEIIEVGEKNAVCSVLVSGHVDGPVWGLATHPSRDFFLSAAEDGTVRLWDIADRKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRFLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADGRHLQVSTGCYKRHVYEVPSGKHLMDQAAIDRITWATWTSILGDEVMGIWSRHAEKADVSCACVSRSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVANIRFTSGDRHVVSAGGDDCSLFVWKCVHMPH", "length": 1977, "header": "tr|A0AAA9SBQ8-1|A0AAA9SBQ8_BOVIN Isoform 1 of EMAP like 5 OS=Bos taurus OX=9913 GN=EML5 PE=3 SV=1 CANONICAL=A0AAA9SBQ8-1" }, "locus": { "chromosome": "10", "start_pos": 100460004, "end_pos": 100303443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106389.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106389.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079663.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079663.1" } ] } }, { "isoform_ac": "A0AAA9TYK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8/entry#A0AAA9TYK9-1", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERALVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDGEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPVRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDVYGVAQRYKKLGECVGSLSFITHLDWSSDSRYLQTNDGNGKRLLYRMPGGKEVASKEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIVKLFRYPCLRKGAKFKKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLADSNSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQYKEKQKSGTSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLALHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGYHQYGVCAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYMGTLGKSDTMMCAVYGRTEDMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHVDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSGEAEKIGWASWTSVLGFCCEAIWPVIGEVTDVTASCLTSDKTVLATGDDLGFVKLFRYPAKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGIKPHLQQKEPSTDERQGVVRGSRPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELVFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAVNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRAGHNQRIFVAEFRPDSDSQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKEKPSKEGGAVKLWDQELRRCRAFRLETGQASDCVRSVCRGKGKILVGTRSAEIIEVGEKNAVCSVLVSGHVDGPVWGLATHPSRDFFLSAAEDGTVRLWDIADRKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRFLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADGRHLQVSTGCYKRHVYEVPSGKHLMDQAAIDRITWATWTSILGDEVMGIWSRHAEKADVSCACVSRSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVANIRFTSGDRHVVSAGGDDCSLFVWKCVHMPH", "length": 1977, "header": "tr|A0AAA9TYK9-1|A0AAA9TYK9_BOVIN Computationally mapped isoform of EMAP like 5 OS=Bos taurus OX=9913 GN=EML5 PE=3 SV=1 CANONICAL=A0AAA9SBQ8-1" }, "locus": { "chromosome": "10", "start_pos": 100460004, "end_pos": 100303443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102592.1" } ] } }, { "isoform_ac": "F1N7B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8/entry#F1N7B8-1", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERALVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDGEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPVRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDVYGVAQRYKKLGECVGSLSFITHLDWSSDSRYLQTNDGNGKRLLYRMPGGKEVASKEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIVKLFRYPCLRKGAKFKKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLADSNSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQYKEKQKSGTSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLALHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGYHQYGVCAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYMGTLGKSDTMMCAVYGRTEDMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHVDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSGEAEKIGWASWTSVLGFCCEAIWPVIGEVTDVTASCLTSDKTVLATGDDLGFVKLFRYPAKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGIKPHLQQKEPSTDERPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELVFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAVNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRAGHNQRIFVAEFRPDSDSQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKEKPSKEGGAVKLWDQELRRCRAFRLETGQASDCVRSVCRGKGKILVGTRSAEIIEVGEKNAVCSVLVSGHVDGPVWGLATHPSRDFFLSAAEDGTVRLWDIADRKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRFLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADGRHLQVSTGCYKRHVYEVPSGKHLMDQAAIDRITWATWTSILGDEVMGIWSRHAEKADVSCACVSRSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVANIRFTSGDRHVVSAGGDDCSLFVWKCVHMPH", "length": 1969, "header": "tr|F1N7B8-1|F1N7B8_BOVIN Computationally mapped isoform of EMAP like 5 OS=Bos taurus OX=9913 GN=EML5 PE=3 SV=3 CANONICAL=A0AAA9SBQ8-1" }, "locus": { "chromosome": "10", "start_pos": 100460004, "end_pos": 100303443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061574.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061574.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053622.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053622.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537305", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q05BV3-1", "protein_name": "Echinoderm microtubule-associated protein-like 5", "gene_name": "EML5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLGIKPHLQQKEPSIDERPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHTPH", "length": 1969 }, "evidence": [ { "id": "A0AAA9SBQ8", "url": "https://omabrowser.org/oma/group/A0AAA9SBQ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6ED65-1", "protein_name": "Echinoderm microtubule-associated protein-like 5", "gene_name": "Eml5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETEQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMDEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECVGSLSFITHLDWSSDSKYLQTNDGSGKRLLYKMPGGKEVTSKEEVKGMHWASWTCVAGLEVNGIWPKYSDINDINSVDGNYVGQVLVTADDYGVVKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLTESNSDESDSDLSDVPELDSEIEQETQLTYHRQVYKEDLPQLKEQCKEKQKSATSKRRERAPGNSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDPSIHVWDTETIKPLSILKGYHQYGICAVDFSADGKRLASVGIDDSHTIVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYVGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDVFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRADLAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPVTLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPGSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKISWATWTSVLGLCCEGIWPIIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPAKGKFGKFKKYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTSEVERHREKKNCDSEESDTDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGVKPHLQQKEPSVDERQGVVRGSRPPVSRAPPQPEKLQSNNVGKKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRCSHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRVVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQVTDCVRSVCRGKGKILVGTRNSEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSRHLQVSSGCYKRHVYEVPSGKHLVDHAAIDRITWATWTSILGDEVMGIWSRHAEKADVTCACVSHSGISLVTGDDFGMVKLYDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSVFVWKCVHTPH", "length": 1977 }, "evidence": [ { "id": "A0AAA9SBQ8", "url": "https://omabrowser.org/oma/group/A0AAA9SBQ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BQM8-1", "protein_name": "Echinoderm microtubule-associated protein-like 5", "gene_name": "Eml5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFFRGHSDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGRMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNSCEEGFATGGRDGCIRLWDLTFKPITVIDLRETEQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNVDGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGAYLAVGCNDSSVDIYGVAQRYKKVGECVGSLSFITHLDWSSDSRYLQTNDGSGKRLLYKMPGGKEVTSKEEIKGMHWASWTCVAGLEVNGIWPKYSDINDINSVDGNYVGQVLVTADDYGVVKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLAESNSDESDSDLSDVPELDSEIEQETQLTYHRQVYKEDLPQLKEQCKEKQKSATSKRRERTPGTSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDPSIHVWDTETIKPLSILKGYHQYGICAVDFSADGKRLASVGIDDSHTIVLWDWKKGEKLSVTRGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGKKGYVGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDVFLVKTVKAHDGPVFSMHALEKGFVTGGKDGMVALWDDSFERCLKTYAIKRADLAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDIISDIRFSPGSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLLQVNTGAKEQLFFEAPRGKRQTIPSVEVEKISWATWTSVLGLCCEGIWPVIGEVTEVTASCLTSDKMVLATGDDLGFVKLFRYPAKGKFGKFKKYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTNEVESHREKKYCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGVKPHLQQKEPSVDERQGVVRGSRPPVSRAPPQPEKLQSNNVGKKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGDDIIYHTASIGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRCSHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFWTLAGRALLSKKGLLSSLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRVVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQVTDCVRSVCRGKGKILVGTRNSEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSRHLQVSSGCYKRHVYEVPSGKHLVDHAAIDRITWATWTSILGDEVMGIWSRHAEKADVTCACVSHSGISLVTGDDFGMVKLYDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHMPH", "length": 1977 }, "evidence": [ { "id": "A0AAA9SBQ8", "url": "https://omabrowser.org/oma/group/A0AAA9SBQ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1582, "end_pos": 1584, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" }, { "id": "PF23409", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23409" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EML-like first beta-propeller", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 307, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBQ8" }, { "id": "PF23414", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23414" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EML-like second beta-propeller", "eco_id": "ECO_0000259", "start_pos": 328, "end_pos": 592, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1582, "end_pos": 1584 }, { "start_pos": 428, "end_pos": 430 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAA4-1", "uniprot_ac": "A0AAA9SAA4", "uniprot_id": "A0AAA9SAA4_BOVIN", "mass": { "chemical_mass": 47342.0, "monoisotopic_mass": 47342.0 }, "refseq": { "ac": "XP_002697641", "name": "adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697641" }, "gene_names": [ { "name": "SLC35B3", "type": "recommended", "evidence": [ { "id": "A0AAA9SAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ] }, { "name": "SLC35B3", "type": "synonym", "evidence": [ { "id": "XP_002697641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697641" } ] } ], "protein_names": [ { "name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SAA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4/entry#names_and_taxonomy" } ] }, { "name": "adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002697641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697641" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC35B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4", "locus": { "chromosome": "23", "start_pos": 47180230, "end_pos": 47158309, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009157", "url": "https://www.ensembl.org/id/ENSBTAG00000009157" } ] } } ], "crossref": [ { "id": "A0AAA9SAA4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009157", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009157", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527615", "url": "https://www.ncbi.nlm.nih.gov/gene/527615", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527615", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527615", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YNRTTQF", "url": "https://omabrowser.org/oma/group/YNRTTQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXE3", "url": "https://www.orthodb.org/?gene=A0A3Q1LXE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BLS0", "url": "https://www.orthodb.org/?gene=E1BLS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10778", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10778", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10778:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10778:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08449", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08449", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-174362", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174362", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-727802", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-727802", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697641", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697641", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXE3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLS0", "url": "https://www.uniprot.org/uniprotkb/E1BLS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLS0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAPGEEAAAAAAAEAEVASAGVGEEETQEDLAQQAEGGLNKGEETNKDNFGSTECGKTRTMDLKFNSSRKYISITVPSKTQAMSPHIKSIDDIVVLGINLSRFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAALCMSLGLIWFTLADSTVAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCSKDPIRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGFLVVLGIFLNVYSKNMDKMRLPSAYDLINRVMDLRKSRTLAQTV", "length": 430, "header": "tr|A0AAA9SAA4-1|A0AAA9SAA4_BOVIN Isoform 1 of Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Bos taurus OX=9913 GN=SLC35B3 PE=3 SV=1 CANONICAL=A0AAA9SAA4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4/entry#A0A3Q1LXE3-1", "sequence": { "sequence": "MDLAQQAEGGLNKGEETNKDNFGSTECGKTRTMDLKFNSSRKYISITVPSKTQAMSPHIKSIDDIVVLGINLSRFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAALCMSLGLIWFTLADSTVAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCSKDPIRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGFLVVLGIFLNVYSKNMDKMRLPSAYDLINRVMDLRKSRTLAQTV", "length": 401, "header": "tr|A0A3Q1LXE3-1|A0AAA9SAA4_BOVIN Computationally mapped isoform of Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Bos taurus OX=9913 GN=SLC35B3 PE=3 SV=2 CANONICAL=A0AAA9SAA4-1" }, "locus": { "chromosome": "23", "start_pos": 47179385, "end_pos": 47160507, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069836.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069836.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065430.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065430.2" } ] } }, { "isoform_ac": "A0AAA9SAA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4/entry#A0AAA9SAA4-1", "sequence": { "sequence": "MRAPGEEAAAAAAAEAEVASAGVGEEETQEDLAQQAEGGLNKGEETNKDNFGSTECGKTRTMDLKFNSSRKYISITVPSKTQAMSPHIKSIDDIVVLGINLSRFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAALCMSLGLIWFTLADSTVAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCSKDPIRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGFLVVLGIFLNVYSKNMDKMRLPSAYDLINRVMDLRKSRTLAQTV", "length": 430, "header": "tr|A0AAA9SAA4-1|A0AAA9SAA4_BOVIN Isoform 1 of Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Bos taurus OX=9913 GN=SLC35B3 PE=3 SV=1 CANONICAL=A0AAA9SAA4-1" }, "locus": { "chromosome": "23", "start_pos": 47179385, "end_pos": 47158373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111467.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111467.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083015.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083015.1" } ] } }, { "isoform_ac": "E1BLS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4/entry#E1BLS0-1", "sequence": { "sequence": "MRAPGEEAAAAAAAEAEVASAGVGEEETQEDLAQQAEGGLNKGEETNKDNFGSTECGKTRTMDLKFNSSRKYISITVPSKTQAMSPHIKSIDDIVVLGINLSRFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAALCMSLGLIWFTLADSTVAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCSKDPIRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYLHLQAQPTAGQKYSRKEKVQNVEKGMCGLVS", "length": 413, "header": "tr|E1BLS0-1|E1BLS0_BOVIN Computationally mapped isoform of Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Bos taurus OX=9913 GN=SLC35B3 PE=3 SV=2 CANONICAL=A0AAA9SAA4-1" }, "locus": { "chromosome": "23", "start_pos": 47179257, "end_pos": 47158373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012065.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012065.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012065.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012065.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527615", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527615", "resource": "KEGG Pathway" }, { "id": "R-BTA-174362", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174362", "resource": "Reactome", "description": "Transport and metabolism of PAPS" }, { "id": "R-BTA-727802", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-727802", "resource": "Reactome", "description": "Transport of nucleotide sugars" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A9F6-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "SLC35B3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDLKFNNSRKYVSITVPSKTQAMSPHIKSIDDIVVLGINLSRFNKLTQFFICVAGVFVFYLIYGYLQELIFSMEGFKPYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAALCMSLGLIWFTLADSTVAPNFNLTGVILISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCSKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIKLPSLYDLISKTMEARKSRTLAQTV", "length": 369 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MBW9-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "Slc35b3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDLKFNNSRKYVSITVPSKTQTMSPHIKSVDDIVVLGINLSKFNKLTQFFICVAGVFVFYLIYGYLQELIFSMEGFKPYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNLADVSAAVCMSLGLIWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHSASNSEMVLYSYSIGFVYILLGLSCTSGLGPAVAFCSKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIRLPSVYNLINKAMDVKKARTLAQTV", "length": 369 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6ACP7-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "Slc35b3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLKFNNSRKYVSITVPSKTQTMSPHIKSVEDVVVLGVNLSRFKKLTQFLICVAGVFVFYLIYGYLQELIFSMEGFKPYGWYLTLVQFAFYSVFGLIELQLTQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNLADVSAAVCMSLGLIWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLSCTSGLGPALAFCSKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFLFFAKPFTFQYIWSGLLVVLGIFLNVYSKNMDKIRLPSVYSVIKKAMDMKKSRTLAQTV", "length": 369 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1P4W7-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "SLC35B3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDLKFTSARKYVSISVPSKSQTMSPHIKSVDDVIVLGINLSKFNKPAQFFICVSGVFMFYLIYGYLQELIFSVEGFKPFGWYLTLVQFGFYSVFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMVGGVFIQGKRYNIADVSAALCMSLGLIWFTLADSTVAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNGSNSEMVLYSYSIGFLYILLGLTCTSGLSPAVAFCSQHPIQTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFLFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIKLPSLHGIWKKNVEERKTRTLSQTV", "length": 369 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q922Q5-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "Slc35b3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLKFNNSRKYVSISVPSKTQAMSPHIKSVEDVVVLGVNLSKFSKLTQFLICVAGVFVFYLIYGYLQELIFSVEGFKPYGWYLTLVQFAFYSVFGLIELQLTQDRRRRIPGKTYMLIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNLADVSAAVCMSLGLIWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLSCTSGLGPAVAFCSKNPVGTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTVVLSFLFFAKPFTFQYIWSGLLVVLGIFLNVYSKNMDKIRLPSVYNMIKKAMDMKKSRTLAQTV", "length": 369 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H1N7-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "SLC35B3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLTQQAKDIQNITVQETNKNNSESIECSKITMDLKFNNSRKYISITVPSKTQTMSPHIKSVDDVVVLGMNLSKFNKLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNVADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCAKNPVRTYGYAFLFSLTGYFGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIRLPSLYDLINKSVEARKSRTLAQTV", "length": 401 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VVD9-1", "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "Papst2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYIDTSASSRMTDNKGSVITINGGESAGNSPPSQRKSSTSESPPELRILCFDLTYYNRTTQFLLSCAGVFFLYILYGYLQELIFTVEGFKPYGWFLTLVQFGYYIGFGLVERRLEGYRISGGSFWNIEPEPRCIPMRTYLILAALTLGTMGLSNSSLGYLNYPTQVIFKCCKLIPVLVGSILIQGKRYGLLDFAAATCMCIGLAWFTLADSQMTPNFNLLGVAMISGALLCDAAIGNVQEKAMREFKAPSSEVVFYSYGLGFVYLFVIMLVTGNFFSGFAFCLEHPVETFGYGFLFSLSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSKRNKLTLADVRQRIKQFGAKVARSPSRKFLIEV", "length": 396 }, "evidence": [ { "id": "A0AAA9SAA4", "url": "https://omabrowser.org/oma/group/A0AAA9SAA4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" }, { "name": "3'-phosphoadenosine 5'-phosphosulfate transport", "id": "GO:0046963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046963", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" }, { "name": "5'-adenylyl sulfate transmembrane transport", "id": "GO:1902558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902558", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "id": "GO:0046964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046964", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDA3-1", "uniprot_ac": "A0AAA9SDA3", "uniprot_id": "A0AAA9SDA3_BOVIN", "mass": { "chemical_mass": 50329.0, "monoisotopic_mass": 50329.0 }, "refseq": { "ac": "XP_024849863", "name": "testican-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849863" }, "gene_names": [ { "name": "SPOCK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ] }, { "name": "SPOCK1", "type": "synonym", "evidence": [ { "id": "XP_024849863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849863" } ] } ], "protein_names": [ { "name": "Testican-3", "type": "recommended", "evidence": [ { "id": "A0AAA9SDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#names_and_taxonomy" } ] }, { "name": "SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#names_and_taxonomy" } ] }, { "name": "testican-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024849863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849863" } ] } ], "function": [ { "annotation": "May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ01", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ01#function" }, { "database": "UniProtKB", "id": "ARBA00053745", "url": "https://www.uniprot.org/uniprotkb/ARBA00053745#function" }, { "database": "UniProtKB", "id": "A0AAA9SJS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJS5#function" }, { "database": "UniProtKB", "id": "F1MVT9", "url": "https://www.uniprot.org/uniprotkb/F1MVT9#function" }, { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPOCK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3", "locus": { "chromosome": "7", "start_pos": 48366666, "end_pos": 48947295, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003502", "url": "https://www.ensembl.org/id/ENSBTAG00000003502" } ] } } ], "crossref": [ { "id": "A0AAA9SDA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003502", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003502", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00191", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00191", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511211", "url": "https://www.ncbi.nlm.nih.gov/gene/511211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MVT9", "url": "https://www.orthodb.org/?gene=F1MVT9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13866", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13866", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13866:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13866:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10591", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10591", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024849863", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849863", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ01", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ01-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVT9", "url": "https://www.uniprot.org/uniprotkb/F1MVT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVT9-1", "url": "https://www.uniprot.org/uniprotkb/F1MVT9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAIAVLAAAAAAWCLLQVESRHLDALAGGAGPNNGNFLDNDQWLSTVSEYERDKYWNRFRDEESSTEEATSSNDDYFRNWNPNKPFDQALDPAKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGTVVHKHWVGPSNLVKCKPCPAAQSAMVCGSDGHTYTSKCKLEFHACSTGRSLTTLCDGPCPCLPEPEPPKHKAEKNACTDKELRNLASRLKDWFGALHEDANRVINPTSSETAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVNCEEEQETSGDFGSGGSVVLLDDLEDEQDLGPKDRLGKPRVHARAVTEDDEDEDDDKEDEVGYIW", "length": 451, "header": "tr|A0AAA9SDA3-1|A0AAA9SDA3_BOVIN Isoform 1 of Testican-3 OS=Bos taurus OX=9913 GN=SPOCK1 PE=1 SV=1 CANONICAL=A0AAA9SDA3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#A0A3Q1LZ01-1", "sequence": { "sequence": "MPAIAVLAAAAAAWCLLQVESRHLDALAGGAGPNNGNFLDNDQWLSTVSEYERDKYWNRFRDDDYFRNWNPNKPFDQALDPAKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGTVVHKHWVGPSNLVKCKPCPAAQSAMVCGSDGHTYTSKCKLEFHACSTGRSLTTLCDGPCPCLPEPEPPKHKAEKNACTDKELRNLASRLKDWFGALHEDANRVINPTSSETAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVNCEEEQETSGDFGSGGSVVLLDDLEDEQDLGPKDRLGKPRVHARAVTEDDEDEDDDKEDEVGYIW", "length": 439, "header": "tr|A0A3Q1LZ01-1|A0AAA9SDA3_BOVIN Computationally mapped isoform of Testican-3 OS=Bos taurus OX=9913 GN=SPOCK1 PE=1 SV=1 CANONICAL=A0AAA9SDA3-1" }, "locus": { "chromosome": "7", "start_pos": 48947295, "end_pos": 48367046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082014.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082014.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066032.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066032.2" } ] } }, { "isoform_ac": "A0AAA9SDA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#A0AAA9SDA3-1", "sequence": { "sequence": "MPAIAVLAAAAAAWCLLQVESRHLDALAGGAGPNNGNFLDNDQWLSTVSEYERDKYWNRFRDEESSTEEATSSNDDYFRNWNPNKPFDQALDPAKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGTVVHKHWVGPSNLVKCKPCPAAQSAMVCGSDGHTYTSKCKLEFHACSTGRSLTTLCDGPCPCLPEPEPPKHKAEKNACTDKELRNLASRLKDWFGALHEDANRVINPTSSETAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVNCEEEQETSGDFGSGGSVVLLDDLEDEQDLGPKDRLGKPRVHARAVTEDDEDEDDDKEDEVGYIW", "length": 451, "header": "tr|A0AAA9SDA3-1|A0AAA9SDA3_BOVIN Isoform 1 of Testican-3 OS=Bos taurus OX=9913 GN=SPOCK1 PE=1 SV=1 CANONICAL=A0AAA9SDA3-1" }, "locus": { "chromosome": "7", "start_pos": 48947295, "end_pos": 48367046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117611.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117611.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081527.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081527.1" } ] } }, { "isoform_ac": "A0AAA9SJS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#A0AAA9SJS5-1", "sequence": { "sequence": "MFHCSLSLPREKLQVGIFLPLDDYFRNWNPNKPFDQALDPAKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGTVVHKHWVGPSNLVKCKPCPAAQSAMVCGSDGHTYTSKCKLEFHACSTGRSLTTLCDGPCPCLPEPEPPKHKAEKNACTDKELRNLASRLKDWFGALHEDANRVINPTSSETAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVNCEEEQETSGDFGSGGSVVLLDDLEDEQDLGPKDRLGKPRVHARAVTEDDEDEDDDKEDEVGYIW", "length": 398, "header": "tr|A0AAA9SJS5-1|A0AAA9SJS5_BOVIN Computationally mapped isoform of Testican-3 OS=Bos taurus OX=9913 GN=SPOCK1 PE=1 SV=1 CANONICAL=A0AAA9SDA3-1" }, "locus": { "chromosome": "7", "start_pos": 48764745, "end_pos": 48367046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122544.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122544.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085584.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085584.1" } ] } }, { "isoform_ac": "A0AAA9SXH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#A0AAA9SXH5-1", "sequence": { "sequence": "MPAIAVLAAAAAAWCLLQVESRHLDALAGGAGPNNGNFLDNDQWLSTVSEYERDKYWNRFRDDDYFRNWNPNKPFDQALDPAKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGTVVHKHWVGPSNLVKCKPCPAAQSAMVCGSDGHTYTSKCKLEFHACSTGRSLTTLCDGPCPCLPEPEPPKHKAEKNGFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVNCEEEQETSGDFGSGGSVVLLDDLEDEQDLGPKDRLGKPRVHARAVTEDDEDEDDDKEDEVGYIW", "length": 400, "header": "tr|A0AAA9SXH5-1|A0AAA9SXH5_BOVIN Computationally mapped isoform of SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 OS=Bos taurus OX=9913 GN=SPOCK1 PE=1 SV=1 CANONICAL=A0AAA9SDA3-1" }, "locus": { "chromosome": "7", "start_pos": 48947295, "end_pos": 48367046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110422.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110422.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088777.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088777.1" } ] } }, { "isoform_ac": "F1MVT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3/entry#F1MVT9-1", "sequence": { "sequence": "RWSCCFCFAESSLWPLCSEEHVHLNLWGECKHVVCLFPTCLFEYKYKLNLPGGPNSYPLAFLASALDPAKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGTVVHKHWVGPSNLVKCKPCPAAQSAMVCGSDGHTYTSKCKLEFHACSTGRSLTTLCDGPCPCLPEPEPPKHKAEKNACTDKELRNLASRLKDWFGALHEDANRVINPTSSETAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVNCEEEQETSGDFGSGGSVVLLDDLEDEQDLGPKDRLGKPRVHARAVTEDDEDEDDDKEDEVGYIW", "length": 426, "header": "tr|F1MVT9-1|A0AAA9SDA3_BOVIN Computationally mapped isoform of Testican-3 OS=Bos taurus OX=9913 GN=SPOCK1 PE=1 SV=4 CANONICAL=A0AAA9SDA3-1" }, "locus": { "chromosome": "7", "start_pos": 48569922, "end_pos": 48367046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004556.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004556.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004556.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004556.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" }, { "name": "metalloendopeptidase inhibitor activity", "id": "GO:0008191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008191", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of neuron projection development", "id": "GO:0010977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" }, { "name": "negative regulation of cell-substrate adhesion", "id": "GO:0010812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010812", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 142, "end_pos": 193, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA3" }, { "id": "PS51162", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51162" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thyroglobulin type-1", "eco_id": "ECO_0000259", "start_pos": 322, "end_pos": 388, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE34-1", "uniprot_ac": "A0AAA9SE34", "uniprot_id": "A0AAA9SE34_BOVIN", "mass": { "chemical_mass": 53092.0, "monoisotopic_mass": 53092.0 }, "refseq": {}, "gene_names": [ { "name": "PRR5", "type": "recommended", "evidence": [ { "id": "A0AAA9SE34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34" } ] } ], "protein_names": [ { "name": "Proline rich 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SE34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34", "locus": { "chromosome": "5", "start_pos": 115320963, "end_pos": 115267547, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039784", "url": "https://www.ensembl.org/id/ENSBTAG00000039784" } ] } } ], "crossref": [ { "id": "A0AAA9SE34", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039784", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039784", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR013745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZK5", "url": "https://www.orthodb.org/?gene=A0A3Q1LZK5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32428:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32428:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08539", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08539", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZK5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZK5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEB7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T497", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T497", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T497-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T497-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RGA5", "url": "https://www.uniprot.org/uniprotkb/F6RGA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RGA5-1", "url": "https://www.uniprot.org/uniprotkb/F6RGA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPPGGRGRPLPRRAPPTACAVHPDGGIRGGHPRLAAPSSGGSRPPGHRSGWACPRPRRPPPAGLRRPRRPGGRGRVGRPARARGAERGGATAAPSPGPGLRLCAAAAAAEAARGPRLKFMSSPSLSDLGKREPAAATAADERGTQQRRACANATWDSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAVFYPVQGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 502, "header": "tr|A0AAA9SE34-1|A0AAA9SE34_BOVIN Isoform 1 of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=1 CANONICAL=A0AAA9SE34-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#A0A3Q1LZK5-1", "sequence": { "sequence": "PGQERAGRRHRRGRAGHAAAPGLRQRHLGQHPQRGDCRLPAQGAARPGAFQPERRCPAAAEDGAGVLLHGVPTEPAADERHGDPARQDPLLRGDRARSHSWPLCPRRPSARRGRRLTGPRALEGQARTEAAGLAGGDLGLLLQRRAAHPAGGLLPRAGERPGPGGGRASALRGPPAPAHAASSRDGRKAAASPGPQEDLRNAQYPTRRRVSVCDGHPSLFRGSHVGPSLLGTRGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 484, "header": "tr|A0A3Q1LZK5-1|A0AAA9SE34_BOVIN Computationally mapped isoform of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=2 CANONICAL=A0AAA9SE34-1" }, "locus": { "chromosome": "5", "start_pos": 115320493, "end_pos": 115294659, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070034.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070034.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066299.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066299.2" } ] } }, { "isoform_ac": "A0A3Q1MEB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#A0A3Q1MEB7-1", "sequence": { "sequence": "MRTPWDGHRVQVIRLKFMSSPSLSDLGKREPAAATAADERGTQQRRACANATWDSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAVFYPVQGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 399, "header": "tr|A0A3Q1MEB7-1|A0AAA9SE34_BOVIN Computationally mapped isoform of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=1 CANONICAL=A0AAA9SE34-1" }, "locus": { "chromosome": "5", "start_pos": 115320493, "end_pos": 115269062, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073741.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073741.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068835.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068835.2" } ] } }, { "isoform_ac": "A0AAA9SE34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#A0AAA9SE34-1", "sequence": { "sequence": "MGPPGGRGRPLPRRAPPTACAVHPDGGIRGGHPRLAAPSSGGSRPPGHRSGWACPRPRRPPPAGLRRPRRPGGRGRVGRPARARGAERGGATAAPSPGPGLRLCAAAAAAEAARGPRLKFMSSPSLSDLGKREPAAATAADERGTQQRRACANATWDSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAVFYPVQGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 502, "header": "tr|A0AAA9SE34-1|A0AAA9SE34_BOVIN Isoform 1 of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=1 CANONICAL=A0AAA9SE34-1" }, "locus": { "chromosome": "5", "start_pos": 115320493, "end_pos": 115267687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115809.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115809.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083662.1" } ] } }, { "isoform_ac": "A0AAA9T497-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#A0AAA9T497-1", "sequence": { "sequence": "MKFMSSPSLSDLGKREPAAATAADERGTQQRRACANATWDSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAVFYPVQGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 385, "header": "tr|A0AAA9T497-1|A0AAA9T497_BOVIN Computationally mapped isoform of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=2 CANONICAL=A0AAA9SE34-1" }, "locus": { "chromosome": "5", "start_pos": 115320493, "end_pos": 115294627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116741.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116741.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091334.1" } ] } }, { "isoform_ac": "A0AAA9TVS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#A0AAA9TVS6-1", "sequence": { "sequence": "MRTPWDGHRVQVIRLKFMSSPSLSDLGKREPAAATAADERGTQQRRACANATWDSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQGGDGISTWALQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAVFYPVQGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 410, "header": "tr|A0AAA9TVS6-1|A0AAA9TVS6_BOVIN Computationally mapped isoform of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=1 CANONICAL=A0AAA9SE34-1" }, "locus": { "chromosome": "5", "start_pos": 115320493, "end_pos": 115269062, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108940.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108940.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102450.1" } ] } }, { "isoform_ac": "F6RGA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34/entry#F6RGA5-1", "sequence": { "sequence": "MSSPSLSDLGKREPAAATAADERGTQQRRACANATWDSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEDAGLAHAQSHPTAARELSRLSSRRRRRGPQGTFVCRPSSLGGQKLLDSLAETWDFFFSDVLPTLQAVFYPVQGKEPSVRQLALLHFRNTITLGVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTKDYLRLETLIQKVVSPYLGTYGLYSGEGAFTHSCILEKHYLRRSRSGDVLAKNPVVRSKSYNTPLLNPVAEHEAEGAAAGGAGVRRHSVSEMTSCPEPQGFADTPGPGPAGAFGTSPSSPPSGPCANRLYPPAQPPKPGPGAARGSPASSSPENLVDQILESVDSDSEGIFIDFGRGGGSGTSEFDGAGGRQSVV", "length": 423, "header": "tr|F6RGA5-1|F6RGA5_BOVIN Computationally mapped isoform of Proline rich 5 OS=Bos taurus OX=9913 GN=PRR5 PE=3 SV=1 CANONICAL=A0AAA9SE34-1" }, "locus": { "chromosome": "5", "start_pos": 115320493, "end_pos": 115294636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057307.3", "url": "https://www.ensembl.org/id/ENSBTAT00000057307.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049385.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049385.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "TORC2 signaling", "id": "GO:0038203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "TORC2 complex", "id": "GO:0031932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD41-1", "uniprot_ac": "A0AAA9SD41", "uniprot_id": "A0AAA9SD41_BOVIN", "mass": { "chemical_mass": 39424.0, "monoisotopic_mass": 39424.0 }, "refseq": { "ac": "XP_005208870", "name": "ELAV-like protein 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208870" }, "gene_names": [ { "name": "ELAVL3", "type": "recommended", "evidence": [ { "id": "A0AAA9SD41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" } ] }, { "name": "ELAVL3", "type": "synonym", "evidence": [ { "id": "XP_005208870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208870" } ] } ], "protein_names": [ { "name": "ELAV-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SD41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41/entry#names_and_taxonomy" } ] }, { "name": "ELAV-like protein 3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005208870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208870" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELAVL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41", "locus": { "chromosome": "7", "start_pos": 15827840, "end_pos": 15844369, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014412", "url": "https://www.ensembl.org/id/ENSBTAG00000014412" } ] } } ], "crossref": [ { "id": "A0AAA9SD41", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014412", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014412", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12655", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12655", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12772", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12772", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12776", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12776", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520376", "url": "https://www.ncbi.nlm.nih.gov/gene/520376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520376", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M098", "url": "https://www.orthodb.org/?gene=A0A3Q1M098", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4V6", "url": "https://www.orthodb.org/?gene=F1N4V6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208870", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208870", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M098", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M098", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M098-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M098-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4V6", "url": "https://www.uniprot.org/uniprotkb/F1N4V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4V6-1", "url": "https://www.uniprot.org/uniprotkb/F1N4V6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVTILGAMESQVAGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTQLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA", "length": 366, "header": "tr|A0AAA9SD41-1|A0AAA9SD41_BOVIN Isoform 1 of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL3 PE=3 SV=1 CANONICAL=A0AAA9SD41-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M098-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41/entry#A0A3Q1M098-1", "sequence": { "sequence": "MESQVAGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTQLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA", "length": 359, "header": "tr|A0A3Q1M098-1|A0AAA9SD41_BOVIN Computationally mapped isoform of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL3 PE=3 SV=2 CANONICAL=A0AAA9SD41-1" }, "locus": { "chromosome": "7", "start_pos": 15836802, "end_pos": 15828844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076403.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076403.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061382.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061382.2" } ] } }, { "isoform_ac": "A0AAA9SD41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41/entry#A0AAA9SD41-1", "sequence": { "sequence": "MVTILGAMESQVAGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTQLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA", "length": 366, "header": "tr|A0AAA9SD41-1|A0AAA9SD41_BOVIN Isoform 1 of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL3 PE=3 SV=1 CANONICAL=A0AAA9SD41-1" }, "locus": { "chromosome": "7", "start_pos": 15843987, "end_pos": 15828844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099799.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099799.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080236.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080236.1" } ] } }, { "isoform_ac": "F1N4V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41/entry#F1N4V6-1", "sequence": { "sequence": "MTRKQKPKEEPRLSLRTYSHMVAELPPVCWPVIRNSSEVQHIQQILGAMESQVAGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTQLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKRFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA", "length": 400, "header": "tr|F1N4V6-1|F1N4V6_BOVIN Computationally mapped isoform of ELAV-like protein OS=Bos taurus OX=9913 GN=ELAVL3 PE=3 SV=4 CANONICAL=A0AAA9SD41-1" }, "locus": { "chromosome": "7", "start_pos": 15840382, "end_pos": 15828844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019169.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019169.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019169.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019169.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520376", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" } ], "pmid": "" }, { "name": "protein-RNA adaptor activity", "id": "GO:0140517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" } ], "pmid": "" }, { "name": "mRNA 3'-UTR AU-rich region binding", "id": "GO:0035925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD41" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 116, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 289, "end_pos": 291 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE71-1", "uniprot_ac": "A0AAA9SE71", "uniprot_id": "A0AAA9SE71_BOVIN", "mass": { "chemical_mass": 69543.0, "monoisotopic_mass": 69543.0 }, "refseq": {}, "gene_names": [ { "name": "PEX5L", "type": "recommended", "evidence": [ { "id": "A0AAA9SE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ] } ], "protein_names": [ { "name": "PEX5-related protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#names_and_taxonomy" } ] }, { "name": "PEX5-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#names_and_taxonomy" } ] }, { "name": "Peroxin-5-related protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#names_and_taxonomy" } ] }, { "name": "Tetratricopeptide repeat-containing Rab8b-interacting protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SE71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M223", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M223#function" }, { "database": "UniProtKB", "id": "ARBA00056540", "url": "https://www.uniprot.org/uniprotkb/ARBA00056540#function" }, { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71#function" }, { "database": "UniProtKB", "id": "F1MSB4", "url": "https://www.uniprot.org/uniprotkb/F1MSB4#function" }, { "database": "UniProtKB", "id": "A0AAA9TFK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFK1#function" }, { "database": "UniProtKB", "id": "A0A3Q1NEZ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEZ3#function" }, { "database": "UniProtKB", "id": "A0AAA9TLB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB0#function" }, { "database": "UniProtKB", "id": "A0AAA9TLX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX4#function" }, { "database": "UniProtKB", "id": "A0AAA9TWA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PEX5L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71", "locus": { "chromosome": "1", "start_pos": 87382423, "end_pos": 87028846, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013219", "url": "https://www.ensembl.org/id/ENSBTAG00000013219" } ] } } ], "crossref": [ { "id": "A0AAA9SE71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531027", "url": "https://www.ncbi.nlm.nih.gov/gene/531027", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531027", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531027", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M223", "url": "https://www.orthodb.org/?gene=A0A3Q1M223", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSB4", "url": "https://www.orthodb.org/?gene=F1MSB4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10130:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10130:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M223", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M223", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M223-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M223-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NEZ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NEZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSB4", "url": "https://www.uniprot.org/uniprotkb/F1MSB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSB4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYQGHMQKSKEKGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 626, "header": "tr|A0AAA9SE71-1|A0AAA9SE71_BOVIN Isoform 1 of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=2 CANONICAL=A0AAA9SE71-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M223-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0A3Q1M223-1", "sequence": { "sequence": "MYQGHMQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 567, "header": "tr|A0A3Q1M223-1|A0AAA9SE71_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=3 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87029045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071359.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071359.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064035.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064035.3" } ] } }, { "isoform_ac": "A0A3Q1NEZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0A3Q1NEZ3-1", "sequence": { "sequence": "MYQGHMQVVGVTLKKKWHCLQKSDLTLALLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 589, "header": "tr|A0A3Q1NEZ3-1|A0A3Q1NEZ3_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=1 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87029045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079053.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079053.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070252.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070252.2" } ] } }, { "isoform_ac": "A0AAA9SE71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0AAA9SE71-1", "sequence": { "sequence": "MYQGHMQKSKEKGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 626, "header": "tr|A0AAA9SE71-1|A0AAA9SE71_BOVIN Isoform 1 of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=2 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87029045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099535.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099535.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084429.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084429.2" } ] } }, { "isoform_ac": "A0AAA9TFK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0AAA9TFK1-1", "sequence": { "sequence": "MQMSYLKSKEKGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 625, "header": "tr|A0AAA9TFK1-1|A0AAA9TFK1_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=2 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87101296, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115452.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115452.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097343.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097343.2" } ] } }, { "isoform_ac": "A0AAA9TLB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0AAA9TLB0-1", "sequence": { "sequence": "MYQGHMQKSKEKGYGKLSSDEDLEIIVDQKQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 591, "header": "tr|A0AAA9TLB0-1|A0AAA9TLB0_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=2 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87029045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126314.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126314.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097726.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097726.2" } ] } }, { "isoform_ac": "A0AAA9TLX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0AAA9TLX4-1", "sequence": { "sequence": "MQMSYLKSKEKGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTADIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 560, "header": "tr|A0AAA9TLX4-1|A0AAA9TLX4_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=2 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87101296, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123592.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123592.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097300.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097300.2" } ] } }, { "isoform_ac": "A0AAA9TWA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#A0AAA9TWA7-1", "sequence": { "sequence": "MYQGHMQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 602, "header": "tr|A0AAA9TWA7-1|A0AAA9TWA7_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=1 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87029045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127218.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127218.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102903.1" } ] } }, { "isoform_ac": "F1MSB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71/entry#F1MSB4-1", "sequence": { "sequence": "MYQGHMQVVGVTLKKKWHCLQKSDLTLALGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQSKAKKLEASSKTSSLKKKADGSDLISADAEQRGQALRGSETASLDLNIQTQLEKWDDVKFHGDRNSKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVPPTQARLTKEQRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACEALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDVIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP", "length": 624, "header": "tr|F1MSB4-1|F1MSB4_BOVIN Computationally mapped isoform of PEX5-related protein OS=Bos taurus OX=9913 GN=PEX5L PE=3 SV=4 CANONICAL=A0AAA9SE71-1" }, "locus": { "chromosome": "1", "start_pos": 87336584, "end_pos": 87029045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017592.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017592.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017592.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017592.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531027", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531027", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" }, { "name": "peroxisome targeting sequence binding", "id": "GO:0000268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" }, { "name": "peroxisome matrix targeting signal-1 binding", "id": "GO:0005052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein import into peroxisome matrix, docking", "id": "GO:0016560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016560", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAC7-1", "uniprot_ac": "A0AAA9SAC7", "uniprot_id": "A0AAA9SAC7_BOVIN", "mass": { "chemical_mass": 32999.0, "monoisotopic_mass": 32999.0 }, "refseq": { "ac": "XP_024840289", "name": "UDP-N-acetylglucosamine transporter TMEM241", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840289" }, "gene_names": [ { "name": "TMEM241", "type": "recommended", "evidence": [ { "id": "A0AAA9SAC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ] }, { "name": "TMEM241", "type": "synonym", "evidence": [ { "id": "XP_024840289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840289" } ] } ], "protein_names": [ { "name": "Transmembrane protein 241", "type": "synonym", "evidence": [ { "id": "A0AAA9SAC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#names_and_taxonomy" } ] }, { "name": "UDP-N-acetylglucosamine transporter TMEM241", "type": "synonym", "evidence": [ { "id": "XP_024840289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840289" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM241", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7", "locus": { "chromosome": "24", "start_pos": 33287875, "end_pos": 33165431, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010037", "url": "https://www.ensembl.org/id/ENSBTAG00000010037" } ] } } ], "crossref": [ { "id": "A0AAA9SAC7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010037", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010037", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614734", "url": "https://www.ncbi.nlm.nih.gov/gene/614734", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR050186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614734", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614734", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCI4", "url": "https://www.orthodb.org/?gene=A0A3Q1MCI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024840289", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840289", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3I6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYI0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCMKKCLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 296, "header": "tr|A0AAA9SAC7-1|A0AAA9SAC7_BOVIN Isoform 1 of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0A3Q1MCI4-1", "sequence": { "sequence": "MCMKKCLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMG", "length": 276, "header": "tr|A0A3Q1MCI4-1|A0AAA9SAC7_BOVIN Computationally mapped isoform of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=2 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33275705, "end_pos": 33169089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078969.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078969.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068064.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068064.2" } ] } }, { "isoform_ac": "A0AAA9S3I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0AAA9S3I6-1", "sequence": { "sequence": "TASLPPSTLYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 281, "header": "tr|A0AAA9S3I6-1|A0AAA9SAC7_BOVIN Computationally mapped isoform of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33286871, "end_pos": 33165448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086572.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086572.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076657.1" } ] } }, { "isoform_ac": "A0AAA9SAC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0AAA9SAC7-1", "sequence": { "sequence": "MCMKKCLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 296, "header": "tr|A0AAA9SAC7-1|A0AAA9SAC7_BOVIN Isoform 1 of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33286871, "end_pos": 33169089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111478.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111478.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079129.1" } ] } }, { "isoform_ac": "A0AAA9SRI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0AAA9SRI6-1", "sequence": { "sequence": "MCMKKCLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 270, "header": "tr|A0AAA9SRI6-1|A0AAA9SRI6_BOVIN Computationally mapped isoform of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33286871, "end_pos": 33169089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078670.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078670.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086586.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086586.1" } ] } }, { "isoform_ac": "A0AAA9SYI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0AAA9SYI0-1", "sequence": { "sequence": "MCMKKCLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCARTSRSRGGQVRVETPVKTVFILHRKRSRKADVLTYVVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 300, "header": "tr|A0AAA9SYI0-1|A0AAA9SYI0_BOVIN Computationally mapped isoform of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33286871, "end_pos": 33169089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135104.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135104.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088407.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088407.1" } ] } }, { "isoform_ac": "A0AAA9TJU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0AAA9TJU3-1", "sequence": { "sequence": "FVPSTAERWSGFPQYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 286, "header": "tr|A0AAA9TJU3-1|A0AAA9TJU3_BOVIN Computationally mapped isoform of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33286871, "end_pos": 33170882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081106.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081106.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098736.1" } ] } }, { "isoform_ac": "A0AAA9TS36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7/entry#A0AAA9TS36-1", "sequence": { "sequence": "TTFLSAREGSWIKLNGIRYVLSVLKFTYPTLFQGWQTLVGGLLLHVSWKLGWVEINSRSRSDVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNAAEVIICGHQKCFRKEKTSPPKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKLNKLSDIDQQYLNYLFSVVLLALAAHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTMKLKSFMAPGQCAAWIFFAKVITSGLSMLLFDTILTRETMGCLLLGGFGEALLVFSERKGS", "length": 290, "header": "tr|A0AAA9TS36-1|A0AAA9TS36_BOVIN Computationally mapped isoform of Transmembrane protein 241 OS=Bos taurus OX=9913 GN=TMEM241 PE=4 SV=1 CANONICAL=A0AAA9SAC7-1" }, "locus": { "chromosome": "24", "start_pos": 33286871, "end_pos": 33165653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071581.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071581.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100143.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100143.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614734", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614734", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "pmid": "" }, { "name": "GDP-mannose transmembrane transporter activity", "id": "GO:0005458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005458", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine transmembrane transporter activity", "id": "GO:0005462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005462", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GDP-mannose transmembrane transport", "id": "GO:1990570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990570", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE38-1", "uniprot_ac": "A0AAA9SE38", "uniprot_id": "A0AAA9SE38_BOVIN", "mass": { "chemical_mass": 28513.0, "monoisotopic_mass": 28513.0 }, "refseq": {}, "gene_names": [ { "name": "SAMD12", "type": "recommended", "evidence": [ { "id": "A0AAA9SE38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38" } ] } ], "protein_names": [ { "name": "Sterile alpha motif domain containing 12", "type": "synonym", "evidence": [ { "id": "A0AAA9SE38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAMD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38", "locus": { "chromosome": "14", "start_pos": 46157719, "end_pos": 45625029, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043996", "url": "https://www.ensembl.org/id/ENSBTAG00000043996" } ] } } ], "crossref": [ { "id": "A0AAA9SE38", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000043996", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043996", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783254", "url": "https://www.ncbi.nlm.nih.gov/gene/783254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCN1", "url": "https://www.orthodb.org/?gene=A0A3Q1MCN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPB7", "url": "https://www.orthodb.org/?gene=A0A3Q1MPB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N763", "url": "https://www.orthodb.org/?gene=F1N763", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20843", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20843", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20843:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20843:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MCN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCN1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPB7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRR9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRR9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXW0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXW0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N763", "url": "https://www.uniprot.org/uniprotkb/F1N763", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N763-1", "url": "https://www.uniprot.org/uniprotkb/F1N763-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQGDRLTQESNPHLLHCERLILYHLSRGFSINAVSLPSCCPASQYEHGLFLTERLTHGTARRYPWSIDRLTRLTEKPPIQSRLRAVENLSLLWIFK", "length": 248, "header": "tr|A0AAA9SE38-1|A0AAA9SE38_BOVIN Isoform 1 of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0A3Q1MCN1-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQVRKHTHTISAPVTVPPCLVLFGIWRFLRSAVLPG", "length": 188, "header": "tr|A0A3Q1MCN1-1|A0AAA9SE38_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=2 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 45885145, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077026.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077026.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068607.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068607.2" } ] } }, { "isoform_ac": "A0A3Q1MPB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0A3Q1MPB7-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQEGDQLDSLKEAAVLWPSLVMGSEDEGQILNSPLENQLTLGKSLNCF", "length": 200, "header": "tr|A0A3Q1MPB7-1|A0AAA9SE38_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=2 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46157717, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080587.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080587.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071488.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071488.2" } ] } }, { "isoform_ac": "A0AAA9RTU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0AAA9RTU8-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQGDRLTQESNPHLLHCERLILYQMPGLFAFAHMFQAKGPKPTEEK", "length": 198, "header": "tr|A0AAA9RTU8-1|A0AAA9SE38_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46055441, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101032.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101032.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075423.1" } ] } }, { "isoform_ac": "A0AAA9SE38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0AAA9SE38-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQGDRLTQESNPHLLHCERLILYHLSRGFSINAVSLPSCCPASQYEHGLFLTERLTHGTARRYPWSIDRLTRLTEKPPIQSRLRAVENLSLLWIFK", "length": 248, "header": "tr|A0AAA9SE38-1|A0AAA9SE38_BOVIN Isoform 1 of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46065903, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105121.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105121.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081853.1" } ] } }, { "isoform_ac": "A0AAA9SFK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0AAA9SFK7-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQGPARLFSRASCTLLYSHKQSMRVSVSPHSCQHLLLYVFFIITILICVKWNVTVILICISLTTNDIEHLFKCLLAICVSSLGKHLL", "length": 239, "header": "tr|A0AAA9SFK7-1|A0AAA9SFK7_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 45887982, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126100.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126100.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084154.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084154.1" } ] } }, { "isoform_ac": "A0AAA9SWV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0AAA9SWV5-1", "sequence": { "sequence": "MSLLLGGRRQEETMRAYWLPSPLRTPALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQASAEGSP", "length": 183, "header": "tr|A0AAA9SWV5-1|A0AAA9SWV5_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=2 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46065706, "end_pos": 45626286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118877.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118877.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088546.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088546.2" } ] } }, { "isoform_ac": "A0AAA9TGV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0AAA9TGV5-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQGGEHPPPQTIKKAGSGRNETSGAENTCDFSHQRAGEQTSAEGSP", "length": 198, "header": "tr|A0AAA9TGV5-1|A0AAA9TGV5_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46065706, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105627.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105627.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096097.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096097.1" } ] } }, { "isoform_ac": "A0ABI0NRR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0ABI0NRR9-1", "sequence": { "sequence": "AIPLWGWGLPPRRARGALPGLWEERKLQSPGCSAPSQEPAASLCVTAAALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQASAEGSP", "length": 205, "header": "tr|A0ABI0NRR9-1|A0ABI0NRR9_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46065706, "end_pos": 45624959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147954.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147954.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106448.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106448.1" } ] } }, { "isoform_ac": "A0ABI0NXW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#A0ABI0NXW0-1", "sequence": { "sequence": "MAVEALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQGCYMSRVNTEQSSLCSTPQPRVLHKCS", "length": 181, "header": "tr|A0ABI0NXW0-1|A0ABI0NXW0_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=1 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46065716, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139148.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139148.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104655.1" } ] } }, { "isoform_ac": "F1N763-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38/entry#F1N763-1", "sequence": { "sequence": "MAVEVLLHWGGNGELGDAELASMEEPTVEPRGLACWHDHVLCGDAFVVCLNIWVPSLREPPVGQDSLKEEGALHCGLNPRGIDHPAHGEGIKLQIEGEGVESQSIKNKTFQKVLDQKGTPKRLQTEAETTKSATVKLSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENLRQLILQQVLQLKVREEVRNLQLLTQASAEGSP", "length": 228, "header": "tr|F1N763-1|F1N763_BOVIN Computationally mapped isoform of Sterile alpha motif domain containing 12 OS=Bos taurus OX=9913 GN=SAMD12 PE=4 SV=4 CANONICAL=A0AAA9SE38-1" }, "locus": { "chromosome": "14", "start_pos": 46065706, "end_pos": 45625228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061009.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061009.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053661.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053661.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SE38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE38" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 143, "start_aa": "Trp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 240, "end_pos": 242 }, { "start_pos": 40, "end_pos": 42 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAQ7-1", "uniprot_ac": "A0AAA9SAQ7", "uniprot_id": "A0AAA9SAQ7_BOVIN", "mass": { "chemical_mass": 76761.0, "monoisotopic_mass": 76761.0 }, "refseq": {}, "gene_names": [ { "name": "ATF6", "type": "recommended", "evidence": [ { "id": "A0AAA9SAQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ] } ], "protein_names": [ { "name": "Activating transcription factor 6", "type": "synonym", "evidence": [ { "id": "A0AAA9SAQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7", "locus": { "chromosome": "3", "start_pos": 7616413, "end_pos": 7846328, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005227", "url": "https://www.ensembl.org/id/ENSBTAG00000005227" } ] } } ], "crossref": [ { "id": "A0AAA9SAQ7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAQ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005227", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14700", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14700", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDS9", "url": "https://www.orthodb.org/?gene=A0A3Q1MDS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MDD8", "url": "https://www.orthodb.org/?gene=F1MDD8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46164", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46164", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46164:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46164:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381033", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381033", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9909505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MDS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDD8", "url": "https://www.uniprot.org/uniprotkb/F1MDD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDD8-1", "url": "https://www.uniprot.org/uniprotkb/F1MDD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SGEPAGVAGTMESPFSPGLPHRPDEDWDSALFAELGYFTDTDDLQLDAANETYESNFDNLDFDLDLMPWETGIWDVNNQFCTVKDIKTEPQPLSPASSSCSISSPQSVDSYSSTQHVPEELDLSSTSQMSPLSLYGESSNNPSSAEPLKEDKPIIGPKSKTENGLTPKKKIQINSKPSIQPKPLLLPAAPKTQTNPSVPAKTIIIQTLPTLMPLAKQQPIISIHPAPTKGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYSRLPLRNTRHKATHFVHLCFRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAAPEAAHVVSTIPESLQ", "length": 689, "header": "tr|A0AAA9SAQ7-1|A0AAA9SAQ7_BOVIN Isoform 1 of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=2 CANONICAL=A0AAA9SAQ7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#A0A3Q1MDS9-1", "sequence": { "sequence": "MESPFSPGLPHRPDEDWDSALFAELGYFTDTDDLQLDAANETYESNFDNLDFDLDLMPWETGIWDVNNQFCTDIKTEPQPLSPASSSCSISSPQSVDSYSSTQHVPEELDLSSTSQMSPLSLYGESSNNPSSAEPLKEDKPIIGPKSKTENGLTPKKKIQINSKPSIQPKPLLLPAAPKTQTNPSVPAKTIIIQTLPTLMPLAKQQPIISIHPAPTKGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININGGSVVKNPPANAGDTGSIPGSGRSPGRGNGNPPKYSCWRILWPEESGGLHDSMVLQRVGHDEAHML", "length": 654, "header": "tr|A0A3Q1MDS9-1|A0AAA9SAQ7_BOVIN Computationally mapped isoform of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=2 CANONICAL=A0AAA9SAQ7-1" }, "locus": { "chromosome": "3", "start_pos": 7846013, "end_pos": 7664327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080686.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080686.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069108.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069108.2" } ] } }, { "isoform_ac": "A0AAA9RUA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#A0AAA9RUA8-1", "sequence": { "sequence": "MESPFSPGLPHRPDEDWDSALFAELGYFTDTDDLQLDAANETYESNFDNLDFDLDLMPWETGIWDVNNQFCTDIKTEPQPLSPASSSCSISSPQSVDSYSSTQHVPEELDLSSTSQMSPLSLYGESSNNPSSAEPLKEDKPIIGPKSKTENGLTPKKKIQINSKPSIQPKPLLLPAAPKTQTNPSVPAKTIIIQTLPTLMPLAKQQPIISIHPAPTKGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININGVLPYVSGKSQVRSVFCVSICSMPAC", "length": 614, "header": "tr|A0AAA9RUA8-1|A0AAA9SAQ7_BOVIN Computationally mapped isoform of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=1 CANONICAL=A0AAA9SAQ7-1" }, "locus": { "chromosome": "3", "start_pos": 7846013, "end_pos": 7622165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130028.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130028.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075697.1" } ] } }, { "isoform_ac": "A0AAA9RY04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#A0AAA9RY04-1", "sequence": { "sequence": "MSVKCCLIRITIVLAVSSGKVPDSALFAELGYFTDTDDLQLDAANETYESNFDNLDFDLDLMPWETGIWDVNNQFCTDIKTEPQPLSPASSSCSISSPQSVDSYSSTQHVPEELDLSSTSQMSPLSLYGESSNNPSSAEPLKEDKPIIGPKSKTENGLTPKKKIQINSKPSIQPKPLLLPAAPKTQTNPSVPAKTIIIQTLPTLMPLAKQQPIISIHPAPTKGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAAPEAAHVVSTIPESLQ", "length": 662, "header": "tr|A0AAA9RY04-1|A0AAA9SAQ7_BOVIN Computationally mapped isoform of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=1 CANONICAL=A0AAA9SAQ7-1" }, "locus": { "chromosome": "3", "start_pos": 7845786, "end_pos": 7617012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113308.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113308.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076016.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076016.1" } ] } }, { "isoform_ac": "A0AAA9SA82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#A0AAA9SA82-1", "sequence": { "sequence": "SGEPAGVAGTMESPFSPGLPHRPDEDWGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAAPEAAHVVSTIPESLQ", "length": 467, "header": "tr|A0AAA9SA82-1|A0AAA9SA82_BOVIN Computationally mapped isoform of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=1 CANONICAL=A0AAA9SAQ7-1" }, "locus": { "chromosome": "3", "start_pos": 7846043, "end_pos": 7617012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088304.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088304.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080823.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080823.1" } ] } }, { "isoform_ac": "A0AAA9SAQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#A0AAA9SAQ7-1", "sequence": { "sequence": "SGEPAGVAGTMESPFSPGLPHRPDEDWDSALFAELGYFTDTDDLQLDAANETYESNFDNLDFDLDLMPWETGIWDVNNQFCTVKDIKTEPQPLSPASSSCSISSPQSVDSYSSTQHVPEELDLSSTSQMSPLSLYGESSNNPSSAEPLKEDKPIIGPKSKTENGLTPKKKIQINSKPSIQPKPLLLPAAPKTQTNPSVPAKTIIIQTLPTLMPLAKQQPIISIHPAPTKGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYSRLPLRNTRHKATHFVHLCFRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAAPEAAHVVSTIPESLQ", "length": 689, "header": "tr|A0AAA9SAQ7-1|A0AAA9SAQ7_BOVIN Isoform 1 of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=2 CANONICAL=A0AAA9SAQ7-1" }, "locus": { "chromosome": "3", "start_pos": 7846043, "end_pos": 7617012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127760.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127760.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080990.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080990.2" } ] } }, { "isoform_ac": "F1MDD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7/entry#F1MDD8-1", "sequence": { "sequence": "MESPFSPGLPHRPDEDWDSALFAELGYFTDTDDLQLDAANETYESNFDNLDFDLDLMPWETGIWDVNNQFCTDIKTEPQPLSPASSSCSISSPQSVDSYSSTQHVPEELDLSSTSQMSPLSLYGESSNNPSSAEPLKEDKPIIGPKSKTENGLTPKKKIQINSKPSIQPKPLLLPAAPKTQTNPSVPAKTIIIQTLPTLMPLAKQQPIISIHPAPTKGQTVVLSQPTVVQLQAPGVLPSPQPVLAVAGATTQLPNHVVNVVPAPVANSPANGKLSVTKPVLQSTMKNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALLENEKLKKENGSLKRQLDEVVSENQRLKVPSPKRRAICVMIVLAFVILNYGPMSMLEQDSKRMNPSVNPTNQRRHLLGFSAKEEQDTSDDIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTSRPKMSIVLPAININGNFCPAEVFLQKGHDQYLAKAKSHVFILILPDLTMLFDMVDYSRFFSLPFLFLKTSHLQKS", "length": 649, "header": "tr|F1MDD8-1|F1MDD8_BOVIN Computationally mapped isoform of Activating transcription factor 6 OS=Bos taurus OX=9913 GN=ATF6 PE=3 SV=4 CANONICAL=A0AAA9SAQ7-1" }, "locus": { "chromosome": "3", "start_pos": 7846013, "end_pos": 7671920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061155.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061155.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053726.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053726.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-381033", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381033", "resource": "Reactome", "description": "ATF6 (ATF6-alpha) activates chaperones" }, { "id": "R-BTA-9909505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909505", "resource": "Reactome", "description": "Modulation of host responses by IFN-stimulated genes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "positive regulation of ATF6-mediated unfolded protein response", "id": "GO:1903893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 492, "end_pos": 494, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 603, "end_pos": 605, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ7" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 306, "end_pos": 369, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 352, "end_pos": 354 }, { "start_pos": 492, "end_pos": 494 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 603, "end_pos": 605 }, { "start_pos": 662, "end_pos": 664 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDD2-1", "uniprot_ac": "A0AAA9SDD2", "uniprot_id": "A0AAA9SDD2_BOVIN", "mass": { "chemical_mass": 77458.0, "monoisotopic_mass": 77458.0 }, "refseq": {}, "gene_names": [ { "name": "ADGRL4", "type": "recommended", "evidence": [ { "id": "A0AAA9SDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ] } ], "protein_names": [ { "name": "Adhesion G protein-coupled receptor L4", "type": "recommended", "evidence": [ { "id": "A0AAA9SDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Endothelial orphan receptor that acts as a key regulator of angiogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S674#function" }, { "database": "UniProtKB", "id": "ARBA00056160", "url": "https://www.uniprot.org/uniprotkb/ARBA00056160#function" }, { "database": "UniProtKB", "id": "A0A3Q1MMW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMW0#function" }, { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2#function" }, { "database": "UniProtKB", "id": "A0AAA9SF02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF02#function" }, { "database": "UniProtKB", "id": "F1N570", "url": "https://www.uniprot.org/uniprotkb/F1N570#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADGRL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2", "locus": { "chromosome": "3", "start_pos": 65809581, "end_pos": 65667463, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019733", "url": "https://www.ensembl.org/id/ENSBTAG00000019733" } ] } } ], "crossref": [ { "id": "A0AAA9SDD2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019733", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019733", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15437", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15437", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535066", "url": "https://www.ncbi.nlm.nih.gov/gene/535066", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PYMNVDG", "url": "https://omabrowser.org/oma/group/PYMNVDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEG7", "url": "https://www.orthodb.org/?gene=A0A3Q1MEG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMW0", "url": "https://www.orthodb.org/?gene=A0A3Q1MMW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N570", "url": "https://www.orthodb.org/?gene=F1N570", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16489", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16489", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MEG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S674", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S674-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S674-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N570", "url": "https://www.uniprot.org/uniprotkb/F1N570", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N570-1", "url": "https://www.uniprot.org/uniprotkb/F1N570-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLR", "length": 689, "header": "tr|A0AAA9SDD2-1|A0AAA9SDD2_BOVIN Isoform 1 of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=1 CANONICAL=A0AAA9SDD2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#A0A3Q1MEG7-1", "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSKKNIIDYSKMSLVVSDV", "length": 631, "header": "tr|A0A3Q1MEG7-1|A0A3Q1MEG7_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=4 SV=3 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65807096, "end_pos": 65667544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073076.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073076.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069404.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069404.3" } ] } }, { "isoform_ac": "A0A3Q1MMW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#A0A3Q1MMW0-1", "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLR", "length": 638, "header": "tr|A0A3Q1MMW0-1|A0AAA9SDD2_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=1 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65807101, "end_pos": 65667544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071367.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071367.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070808.1" } ] } }, { "isoform_ac": "A0AAA9S674-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#A0AAA9S674-1", "sequence": { "sequence": "MGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLR", "length": 682, "header": "tr|A0AAA9S674-1|A0AAA9SDD2_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=1 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65807101, "end_pos": 65668337, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091011.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091011.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079344.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079344.1" } ] } }, { "isoform_ac": "A0AAA9S9W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#A0AAA9S9W3-1", "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLR", "length": 631, "header": "tr|A0AAA9S9W3-1|A0AAA9SDD2_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=1 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65807101, "end_pos": 65667544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117299.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117299.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080716.1" } ] } }, { "isoform_ac": "A0AAA9SDD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#A0AAA9SDD2-1", "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLR", "length": 689, "header": "tr|A0AAA9SDD2-1|A0AAA9SDD2_BOVIN Isoform 1 of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=1 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65807101, "end_pos": 65667544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127973.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127973.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081565.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081565.1" } ] } }, { "isoform_ac": "A0AAA9SF02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#A0AAA9SF02-1", "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVALSPPGSSVHVDSPVKNTGVGCYANSRGPSRPRDCISCIEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLR", "length": 728, "header": "tr|A0AAA9SF02-1|A0AAA9SF02_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=1 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65807101, "end_pos": 65667544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126568.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126568.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082414.1" } ] } }, { "isoform_ac": "F1N570-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2/entry#F1N570-1", "sequence": { "sequence": "MRLLPLLVGFSTLLNCCCTQNCTKTPCHPNAKCEIRNGREGCYCNTGYSGNGVTICEDDNECGNLTQSCGENANCTNTQGSYYCMCAPGFRSSNNQDKFITNDGTICVEIVNPDCHLDNACVAENINKTLTKIRHIEEPVALLREVYRNSLKDLSPMDIIAYTEVLAESSPLLGYMNSSNSAKDTSSNSTLTEFVKTLNNFVQKDTFTVWDKLSTNQRITHLTKLIHTAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSHHIKYIHPHMNMDGDNIKIFPKRKTAYDSNGSVAVAFLYYKSIGPLFSSSDNLLEPQSYDKAEEERRVISSVISLSISSNPPTLYELEKVTFTLSHIKTTDKYKSQCAFWNYLPDTMNGSWSSEGCELTHSNDTHTSCRCNHLTHFAILMSSGSSIGIKDYNILTRITQLGIIISLICLALCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIVAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCILSRKIQEEYYRLFKNVPCCFGCLRHHWMKPLFFRMRFHIRLLTFLSDK", "length": 713, "header": "tr|F1N570-1|F1N570_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor L4 OS=Bos taurus OX=9913 GN=ADGRL4 PE=3 SV=3 CANONICAL=A0AAA9SDD2-1" }, "locus": { "chromosome": "3", "start_pos": 65809469, "end_pos": 65667544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026299.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026299.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026299.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026299.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AGR4-1", "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "ADGRL4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLLPLLVGFSTLLNCSYTQNCTKKPCVPNARCEIRNGAEGCYCNIGFSGNGVSICEDDNECGNLTQSCGENANCTNTEGSYYCMCEPGFRSSNNQDKFITNDGTTCIEIVNADCHLDNACIAANINKTLTKMRHIGEPVALLQEIYRNSAKDLSPVDVITYIEVLAESSTLLGYMNSTANSAKDTLSNSTLTEFVKTVNNFVQRDTFIVWDKLSMHHRTTHLTKLIHAAEQATLRISQNFQKTTQFDTNSSDIALKAFFFDSYHMKHIHPHMNVDGDDIRIFPKRKAAYNSNGNVAVAFLHYKSIGPLFSSSDNFLLEPQSYDEAEEDGRVISSVISVSISSNPPTLYELEKITFTLSHVKTADKDSSRCAFWNYLPDTMNGSWSSEGCELMYSNETHTSCRCNHLTHFAILMSSGSSVGIKDYNTLTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAEFVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR", "length": 691 }, "evidence": [ { "id": "A0AAA9SDD2", "url": "https://omabrowser.org/oma/group/A0AAA9SDD2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZDM3-1", "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "ADGRL4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKLLPFLVLVSSLLDYGYATASCNMTCHKDARCEVQGGTQGCYCSQGYTGNGITFCYDDNECENATQPCGEHANCTNTVGSYFCMCAPGFKSSNGQKTFVPNDGTSCVENPEAKCVLYKDCVTEHVNKTLAEIRRLKTPLEMLQEINRNTLGPLLPVDVISYIEALSYSSLNTMQYSVPDNEALRNTTINVLVSTVNNFLQKDKITIWEELPVDNQRQSLTKLLHTAEQATLLMSQNFKKTTQLDANASDIALKVFAFDSHHMKHIHPHVYTEGDYVKISPKKKEEYQPNGTVAVVFLRYSNIGSLLSSPKNRSSKDSSEQRETVSSSVIAVAISSNPPTLYELEKITFTLKYTKTADKDIKCAFWNYSADTMNGNWATEGCELTHSNSTHISCKCNHLTHFAVLMSSGGSVGVSNYNILTRITQLGIIISLICLSMCIFTFWFFSEIQSTRTTIHKNLCCSLFLAELIFLIGINMNNNKLICSITAGLLHYFLLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYVFGYVSPAVVVGISAALGYKYYGTTEVCWLSTKNNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAMLKPEVSCYENIRSCARGALALLFLLGATWIFGVLHVVQGSVVTAYLFTVFNAFQGMFIFIFLCVLSRKIQEEYYRLFKNVPCCFGCLR", "length": 683 }, "evidence": [ { "id": "A0AAA9SDD2", "url": "https://omabrowser.org/oma/group/A0AAA9SDD2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7SY09-1", "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "adgrl4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKLLLFAAWFSSLLDPCRFLDICQSCHPNADCDDICKCRTGYTGNGISDCRDDNECETVPEICGLHANCTNYVGGYYCNCLSGFISNGTEQFQTNDGTSCNDINECEEDRKCGPNSKCHNNIGSFICSCLRGYTSPAGPWFMPNHGTDCIENSKIHCHQDHKCTKETVNSTLERMTNLSISERLKEIRYQTSAALSPVLLISYIEAMVSSKLNSGDVSKDSKEHVNETITNLVFSVNNLVEKDEKVEWKKINEDLRMYYVTKLLHTAEKETLALSAGYTHATQMQVHAGDVEMKLYTFEPRQAQKHPLSANIQGNSISLSTKKARHANNNGSTSVVFLIYHSIGDLLKPADDPGVADYSRYAAAGEITVNSPVIAAAISNQKTLPLNDVTFTLKHTQEIDPARDETKCAFWEYSPSMMGHWSLDGCIRTRVNTTHTSCSCNHLTHFAILMSSARANLLAHYNVLTRITQLGMVISLICLSMCIFTFWFFRDIQNTRTTIHKNLCCSLFMAQFIFLIGINKSAHKWFCSLIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHRNFYAFGYGSPAVVVAISATLGYKYYGTSSVCWLSTENNFIWSFIGPAILIILVNLLAFAVIIYKVYRHTAVKKPEISHYENIRSCARGAIALLFVLGVTWAFGVMYILYETTLTAYLFTFANVFQGMFIFIFLCVLSRRIQEEYYRLFKNMPCCFECLR", "length": 727 }, "evidence": [ { "id": "A0AAA9SDD2", "url": "https://omabrowser.org/oma/group/A0AAA9SDD2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q923X1-1", "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "Adgrl4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLLPLLVGFSTLLNCSYTQNCSKTTCLPNAKCEVHNGVEACFCSQGYSGNGVTICEDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPNDGSYCQDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPNDGSYCQESMNSNCHLEHACIAANINKTLKRIGPITEQTTLLQEIYRNSEAELSLMDIVTYIEILTESSSLLGHPNSTTSYKDAHFNSTLTEFGETINNFVERSTHKMWDQLPTNHRRLHLTKLMHTAELVTLQIAQNTQKNSQFDMNSTDLALKVFAFDSTHMKHAHPHMNVDGGYVKISPRRKAAHGTTGNVVVAFLCYKSIGPLLSSSDNFLLDTQNDNSEGKEKVISSVISASISSNPPTLYELEKITFTLSHVKLSDKHRTQCAFWNYSVDAMNNGSWSTEGCELTHSNDTHTSCRCSHLTHFAILMSSTSSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLIGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR", "length": 739 }, "evidence": [ { "id": "A0AAA9SDD2", "url": "https://omabrowser.org/oma/group/A0AAA9SDD2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ESC1-1", "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "Adgrl4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLLLLLVGLSTLLNHSYTQNCKTPCLPNAKCEVLDEVAACFCSTGYTGNGITICEDVDECNETSVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDGSYCQDVDECNETSVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDGSYCQEIVNSNCHLEHDCIAANINKTLKRIGPITEQLTLLHEIYKNSEAELSLVDIVTYIEILTESSSLQGYIKNTTSPKDAYFGSALTEFGKTVNNFVEKNTHEMWDQLPTNRRRLHLTKLMHAAEHVTLQISQNIQKNTQFDMNSTDLALKVFVFDSVHMKHTHPHMNVDGGYVKISPRRKSAYDPNGNVIVAFLCYRSIGPLLSSSDDFLLGAQSDNSKGKEKVISSVISASISSNPPTLYELEKITFTLSHVKLSDKHQTQCAFWNYSVDDMNNGSWSSEGCELTYSNDTHTSCRCSHLTHFAILMSPSTSIEVKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAQLVFLVGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIYLYLIVVGLIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWTFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFECLR", "length": 738 }, "evidence": [ { "id": "A0AAA9SDD2", "url": "https://omabrowser.org/oma/group/A0AAA9SDD2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9HBW9-1", "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "ADGRL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYCNMGFSGNGVTICEDDNECGNLTQSCGENANCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTISAKDTLSNSTLTEFVKTVNNFVQRDTFVVWDKLSVNHRRTHLTKLMHTVEQATLRISQSFQKTTEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDGDYINIFPKRKAAYDSNGNVAVAFVYYKSIGPLLSSSDNFLLKPQNYDNSEEEERVISSVISVSMSSNPPTLYELEKITFTLSHRKVTDRYRSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGPSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR", "length": 690 }, "evidence": [ { "id": "A0AAA9SDD2", "url": "https://omabrowser.org/oma/group/A0AAA9SDD2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 96, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 426, "end_pos": 667, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD2" }, { "id": "PS50221", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50221" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAIN-B", "eco_id": "ECO_0000259", "start_pos": 244, "end_pos": 418, "start_aa": "Thr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 21, "end_pos": 23 }, { "start_pos": 249, "end_pos": 251 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 394, "end_pos": 396 }, { "start_pos": 64, "end_pos": 66 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBA5-1", "uniprot_ac": "A0AAA9SBA5", "uniprot_id": "A0AAA9SBA5_BOVIN", "mass": { "chemical_mass": 24868.0, "monoisotopic_mass": 24868.0 }, "refseq": { "ac": "XP_003586080", "name": "THAP domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586080" }, "gene_names": [ { "name": "THAP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SBA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" } ] }, { "name": "THAP2", "type": "synonym", "evidence": [ { "id": "XP_003586080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586080" } ] } ], "protein_names": [ { "name": "THAP domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SBA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5/entry#names_and_taxonomy" } ] }, { "name": "THAP domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_003586080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586080" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THAP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5", "locus": { "chromosome": "5", "start_pos": 1313379, "end_pos": 1294605, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052417", "url": "https://www.ensembl.org/id/ENSBTAG00000052417" } ] } } ], "crossref": [ { "id": "A0AAA9SBA5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052417", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052417", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781850", "url": "https://www.ncbi.nlm.nih.gov/gene/781850", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781850", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781850", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RGTSEHI", "url": "https://omabrowser.org/oma/group/RGTSEHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MWE2", "url": "https://www.orthodb.org/?gene=A0A3Q1MWE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47696", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47696", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47696:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47696:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003586080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWE2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCTPTGPSNLKSSISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKAACLVKNLETNNALRKGTSEYILPAALNSLALEDFKILEQDQQGKTLS", "length": 216, "header": "tr|A0AAA9SBA5-1|A0AAA9SBA5_BOVIN Isoform 1 of THAP domain containing 2 OS=Bos taurus OX=9913 GN=THAP2 PE=4 SV=1 CANONICAL=A0AAA9SBA5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MWE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5/entry#A0A3Q1MWE2-1", "sequence": { "sequence": "MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCTPTGPSNLKSSISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKAACLVKNLETNNALRKGTSEYILPAALNSLALEDFKILEQDQQEFSTEARWL", "length": 220, "header": "tr|A0A3Q1MWE2-1|A0AAA9SBA5_BOVIN Computationally mapped isoform of THAP domain containing 2 OS=Bos taurus OX=9913 GN=THAP2 PE=4 SV=2 CANONICAL=A0AAA9SBA5-1" }, "locus": { "chromosome": "5", "start_pos": 1312375, "end_pos": 1294809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074615.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074615.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059729.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059729.2" } ] } }, { "isoform_ac": "A0AAA9SBA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5/entry#A0AAA9SBA5-1", "sequence": { "sequence": "MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCTPTGPSNLKSSISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKAACLVKNLETNNALRKGTSEYILPAALNSLALEDFKILEQDQQGKTLS", "length": 216, "header": "tr|A0AAA9SBA5-1|A0AAA9SBA5_BOVIN Isoform 1 of THAP domain containing 2 OS=Bos taurus OX=9913 GN=THAP2 PE=4 SV=1 CANONICAL=A0AAA9SBA5-1" }, "locus": { "chromosome": "5", "start_pos": 1307339, "end_pos": 1294809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117648.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117648.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082662.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781850", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781850", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3H4R1-1", "protein_name": "THAP domain-containing protein 2 isoform X5", "gene_name": "LOC100760567", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPTNCAAAGCAATYNKHINVSFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNDSFTPSGPCTLKPNSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKMCLQRERRATRRWVKATCFVKNLEASNMLPKGIAEHILPTALSSLPLEDCKLLEQDQQGKTLPVL", "length": 216 }, "evidence": [ { "id": "A0AAA9SBA5", "url": "https://omabrowser.org/oma/group/A0AAA9SBA5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LLL1-1", "protein_name": "THAP domain containing 2", "gene_name": "THAP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNVLKKNSCTPTGPASLKSNITSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANNLLPKGTSEHILPTALSSLPLEDFKILEQDQ", "length": 209 }, "evidence": [ { "id": "A0AAA9SBA5", "url": "https://omabrowser.org/oma/group/A0AAA9SBA5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D305-1", "protein_name": "THAP domain-containing protein 2", "gene_name": "Thap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTNCAAAGCAATYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSLKLKSRNLLKTNNSFPPTGPCNLKLNGSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRKKMKTCLQRERRATRRWIKATCFVKSLEASNMLPKGISEQILPTALSNLPLEDLKSLEQDQQDKTVPIL", "length": 217 }, "evidence": [ { "id": "A0AAA9SBA5", "url": "https://omabrowser.org/oma/group/A0AAA9SBA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0W7-1", "protein_name": "THAP domain-containing protein 2", "gene_name": "THAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEASCFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQVLLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANSVLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTKSTFI", "length": 228 }, "evidence": [ { "id": "A0AAA9SBA5", "url": "https://omabrowser.org/oma/group/A0AAA9SBA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA5" }, { "id": "PS50950", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50950" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THAP-type", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 80, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 19, "end_pos": 21 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAR4-1", "uniprot_ac": "A0AAA9SAR4", "uniprot_id": "A0AAA9SAR4_BOVIN", "mass": { "chemical_mass": 17497.0, "monoisotopic_mass": 17497.0 }, "refseq": {}, "gene_names": [ { "name": "C20H5orf47", "type": "recommended", "evidence": [ { "id": "A0AAA9SAR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4" } ] } ], "protein_names": [ { "name": "Chromosome 20 C5orf47 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SAR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C20H5orf47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4", "locus": { "chromosome": "20", "start_pos": 5720066, "end_pos": 5702545, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054459", "url": "https://www.ensembl.org/id/ENSBTAG00000054459" } ] } } ], "crossref": [ { "id": "A0AAA9SAR4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054459", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054459", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100295594", "url": "https://www.ncbi.nlm.nih.gov/gene/100295594", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100295594", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295594", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VWNSVYK", "url": "https://omabrowser.org/oma/group/VWNSVYK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MXC8", "url": "https://www.orthodb.org/?gene=A0A3Q1MXC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR38655", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38655", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR38655:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38655:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15730", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15730", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MXC8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXC8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVGRELERDRARFVYVTRFGSHQCGGVLALGGRRAQGPKNAGLKHGHSQEKPRAAAPGSPGAGELPLGFRSGALAASSPAPSSSEPSAHAGLTQKNLAKEFDFPIPLSETSKIMKKKNKKVLVWNGVYKIISKMLEENEKYRLRLKCQQLSRENSKDTK", "length": 161, "header": "tr|A0AAA9SAR4-1|A0AAA9SAR4_BOVIN Isoform 1 of Chromosome 20 C5orf47 homolog OS=Bos taurus OX=9913 GN=C20H5orf47 PE=4 SV=1 CANONICAL=A0AAA9SAR4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4/entry#A0A3Q1MXC8-1", "sequence": { "sequence": "MDSPPVGLGTKRRVRTALRDCPEKPQKCNEGLTQKNLAKEFDFPIPLSETSKIMKKKNKKVLVWNGVYKIISKMLEENEKYRLRLKCQQLSRENSKDTK", "length": 99, "header": "tr|A0A3Q1MXC8-1|A0AAA9SAR4_BOVIN Computationally mapped isoform of Chromosome 20 C5orf47 homolog OS=Bos taurus OX=9913 GN=C20H5orf47 PE=4 SV=1 CANONICAL=A0AAA9SAR4-1" }, "locus": { "chromosome": "20", "start_pos": 5716286, "end_pos": 5703047, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000086827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060346.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060346.1" } ] } }, { "isoform_ac": "A0AAA9SAR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR4/entry#A0AAA9SAR4-1", "sequence": { "sequence": "MAAVGRELERDRARFVYVTRFGSHQCGGVLALGGRRAQGPKNAGLKHGHSQEKPRAAAPGSPGAGELPLGFRSGALAASSPAPSSSEPSAHAGLTQKNLAKEFDFPIPLSETSKIMKKKNKKVLVWNGVYKIISKMLEENEKYRLRLKCQQLSRENSKDTK", "length": 161, "header": "tr|A0AAA9SAR4-1|A0AAA9SAR4_BOVIN Isoform 1 of Chromosome 20 C5orf47 homolog OS=Bos taurus OX=9913 GN=C20H5orf47 PE=4 SV=1 CANONICAL=A0AAA9SAR4-1" }, "locus": { "chromosome": "20", "start_pos": 5716286, "end_pos": 5702545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126184.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126184.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082433.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082433.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100295594", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295594", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAV1-1", "uniprot_ac": "A0AAA9SAV1", "uniprot_id": "A0AAA9SAV1_BOVIN", "mass": { "chemical_mass": 37594.0, "monoisotopic_mass": 37594.0 }, "refseq": {}, "gene_names": [ { "name": "BNIP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SAV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ] } ], "protein_names": [ { "name": "BCL2 interacting protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SAV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BNIP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1", "locus": { "chromosome": "10", "start_pos": 50607733, "end_pos": 50507873, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013493", "url": "https://www.ensembl.org/id/ENSBTAG00000013493" } ] } } ], "crossref": [ { "id": "A0AAA9SAV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N6R4", "url": "https://www.orthodb.org/?gene=F1N6R4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12112:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12112:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-525793", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NJ00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJ00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJ00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPV6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPV6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVK7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVK7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6R4", "url": "https://www.uniprot.org/uniprotkb/F1N6R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6R4-1", "url": "https://www.uniprot.org/uniprotkb/F1N6R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGVELKEEWQDEDFPIPLPEDDSIEADILAVTGPESQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDDLDTPSEDSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQYEEEKLKKKKKRVDQELNGKQDEPKNEQ", "length": 326, "header": "tr|A0AAA9SAV1-1|A0AAA9SAV1_BOVIN Isoform 1 of BCL2 interacting protein 2 OS=Bos taurus OX=9913 GN=BNIP2 PE=4 SV=1 CANONICAL=A0AAA9SAV1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NJ00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1/entry#A0A3Q1NJ00-1", "sequence": { "sequence": "MEGVELKEEWQDEDFPIPLPEDDSIEADILAVTGPESQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDDLDTPSEDSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQYEEEKLKKKKKRVDQELNGKQDEPKNEQTSMQA", "length": 331, "header": "tr|A0A3Q1NJ00-1|A0AAA9SAV1_BOVIN Computationally mapped isoform of BCL2 interacting protein 2 OS=Bos taurus OX=9913 GN=BNIP2 PE=4 SV=2 CANONICAL=A0AAA9SAV1-1" }, "locus": { "chromosome": "10", "start_pos": 50607669, "end_pos": 50564941, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066357.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066357.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072052.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072052.2" } ] } }, { "isoform_ac": "A0AAA9SAV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1/entry#A0AAA9SAV1-1", "sequence": { "sequence": "MEGVELKEEWQDEDFPIPLPEDDSIEADILAVTGPESQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDDLDTPSEDSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQYEEEKLKKKKKRVDQELNGKQDEPKNEQ", "length": 326, "header": "tr|A0AAA9SAV1-1|A0AAA9SAV1_BOVIN Isoform 1 of BCL2 interacting protein 2 OS=Bos taurus OX=9913 GN=BNIP2 PE=4 SV=1 CANONICAL=A0AAA9SAV1-1" }, "locus": { "chromosome": "10", "start_pos": 50577460, "end_pos": 50564941, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110627.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110627.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082470.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082470.1" } ] } }, { "isoform_ac": "A0ABI0NPV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1/entry#A0ABI0NPV6-1", "sequence": { "sequence": "MQLTDFGTVDYQEFVVDIESRLRMEGVELKEEWQDEDFPIPLPEDDSIEADILAVTGPESQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDDLDTPSEDSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQVDQELNGKQDEPKNEQ", "length": 337, "header": "tr|A0ABI0NPV6-1|A0ABI0NPV6_BOVIN Computationally mapped isoform of BCL2 interacting protein 2 OS=Bos taurus OX=9913 GN=BNIP2 PE=4 SV=1 CANONICAL=A0AAA9SAV1-1" }, "locus": { "chromosome": "10", "start_pos": 50577460, "end_pos": 50508028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150290.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150290.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105223.1" } ] } }, { "isoform_ac": "A0ABI0NVK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1/entry#A0ABI0NVK7-1", "sequence": { "sequence": "MEHLQENYFKLEAFRSGTIMQTAGRIYLTFSQLLNQLEIIDSPSAMIKMERLNEEDFGTVDYQEFVVDIESRLRMEGVELKEEWQDEDFPIPLPEDDSIEADILAVTGPESQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDDLDTPSEDSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQVDQELNGKQDEPKNEQ", "length": 388, "header": "tr|A0ABI0NVK7-1|A0ABI0NVK7_BOVIN Computationally mapped isoform of BCL2 interacting protein 2 OS=Bos taurus OX=9913 GN=BNIP2 PE=4 SV=1 CANONICAL=A0AAA9SAV1-1" }, "locus": { "chromosome": "10", "start_pos": 50577460, "end_pos": 50513569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153111.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153111.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105518.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105518.1" } ] } }, { "isoform_ac": "F1N6R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1/entry#F1N6R4-1", "sequence": { "sequence": "MQLTLRGLEKVGVLSLPSERLSVSGSAAVLAAVAQGLGPGLAAVREEQAALGATFCDLAVSPTSPAWRGEEDEEAKASSGDFGTVDYQEFVVDIESRLRMEGVELKEEWQDEDFPIPLPEDDSIEADILAVTGPESQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDDLDTPSEDSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQVDQELNGKQDEPKNEQ", "length": 413, "header": "tr|F1N6R4-1|F1N6R4_BOVIN Computationally mapped isoform of BCL2 interacting protein 2 OS=Bos taurus OX=9913 GN=BNIP2 PE=4 SV=3 CANONICAL=A0AAA9SAV1-1" }, "locus": { "chromosome": "10", "start_pos": 50577460, "end_pos": 50508028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017939.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017939.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017939.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017939.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-525793", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-525793", "resource": "Reactome", "description": "Myogenesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "pmid": "" }, { "name": "spindle pole centrosome", "id": "GO:0031616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV1" }, { "id": "PS50191", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRAL-TRIO", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 304, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCN5-1", "uniprot_ac": "A0AAA9SCN5", "uniprot_id": "A0AAA9SCN5_BOVIN", "mass": { "chemical_mass": 66779.0, "monoisotopic_mass": 66779.0 }, "refseq": { "ac": "XP_024839965", "name": "zinc finger protein 397 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839965" }, "gene_names": [ { "name": "ZNF397", "type": "recommended", "evidence": [ { "id": "A0AAA9SCN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ] }, { "name": "ZNF397", "type": "synonym", "evidence": [ { "id": "XP_024839965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839965" } ] } ], "protein_names": [ { "name": "Zinc finger protein 397", "type": "recommended", "evidence": [ { "id": "A0AAA9SCN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 397 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839965" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF397", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5", "locus": { "chromosome": "24", "start_pos": 21768421, "end_pos": 21783976, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010252", "url": "https://www.ensembl.org/id/ENSBTAG00000010252" } ] } } ], "crossref": [ { "id": "A0AAA9SCN5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010252", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010252", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506448", "url": "https://www.ncbi.nlm.nih.gov/gene/506448", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIB9", "url": "https://www.orthodb.org/?gene=A0A452DIB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF85", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF85", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839965", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839965", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIB9", "url": "https://www.uniprot.org/uniprotkb/A0A452DIB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIB9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S304", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S304", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S304-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S304-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVESRAVSTPVPQNSQEQELILVKVEESRSWGQKLKQSGSARSCQELFRQQFRKFCYQETPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEEAVTLLEDLEREFDDPGQQVGTGRCDMLWEKECTDSSMWHHHKNGVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPCLPPKSVSNKQGPQSPKDERRQPVLEISGCENNESAIKKDISGEKSQRLSQEPSFGGFSEHKSSLEWQQGSAPGETLRRSPSQRASFSPVIFTHKLLANRDHPEPQRNLILSTNSVTYQKVPTEERPYRCDICGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGEKPYECNECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGEEAYICSECGKAFRHRSVLTRHQRVHTVK", "length": 582, "header": "tr|A0AAA9SCN5-1|A0AAA9SCN5_BOVIN Isoform 1 of Zinc finger protein 397 OS=Bos taurus OX=9913 GN=ZNF397 PE=3 SV=1 CANONICAL=A0AAA9SCN5-1" }, "isoforms": [ { "isoform_ac": "A0A452DIB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5/entry#A0A452DIB9-1", "sequence": { "sequence": "MAVESRAVSTPVPQNSQEQELILVKVEESRSWGQKLKQSGSARSCQELFRQQFRKFCYQETPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEEAVTLLEDLEREFDDPGQQVGTGRCDMLWEKECTDSSMWHHHKNGVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPCLPPKSGCENNESAIKKDISGEKSQRLSQEPSFGGFSEHKSSLEWQQGSAPGETLRRSPSQRASFSPVIFTHKLLANRDHPEPQRNLILSTNSVTYQKVPTEERPYRCDICGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGEKPYECNECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGEEAYICSECGKAFRHRSVLTRHQRVHTVK", "length": 560, "header": "tr|A0A452DIB9-1|A0AAA9SCN5_BOVIN Computationally mapped isoform of Zinc finger protein 397 OS=Bos taurus OX=9913 GN=ZNF397 PE=3 SV=1 CANONICAL=A0AAA9SCN5-1" }, "locus": { "chromosome": "24", "start_pos": 21783891, "end_pos": 21779528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013542.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013542.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013542.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013542.5" } ] } }, { "isoform_ac": "A0AAA9S304-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5/entry#A0AAA9S304-1", "sequence": { "sequence": "MAVESRAVSTPVPQNSQEQELILVKVEESRSWGQKLKQSGSARSCQELFRQQFRKFCYQETPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEEAVTLLEDLEREFDDPGQQVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPCLPPKSEFSRRACSQQTTCTQISNTDFSSCKTYY", "length": 213, "header": "tr|A0AAA9S304-1|A0AAA9SCN5_BOVIN Computationally mapped isoform of Zinc finger protein 397 OS=Bos taurus OX=9913 GN=ZNF397 PE=3 SV=1 CANONICAL=A0AAA9SCN5-1" }, "locus": { "chromosome": "24", "start_pos": 21783891, "end_pos": 21768439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092309.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092309.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076481.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076481.1" } ] } }, { "isoform_ac": "A0AAA9S8J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5/entry#A0AAA9S8J1-1", "sequence": { "sequence": "MAVESRAVSTPVPQNSQEQELILVKVEESRSWGQKLKQSGSARSCQELFRQQFRKFCYQETPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEEAVTLLEDLEREFDDPGQQVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPCLPPKSGKKKLIWKLIRPLVSRIGN", "length": 204, "header": "tr|A0AAA9S8J1-1|A0AAA9SCN5_BOVIN Computationally mapped isoform of Zinc finger protein 397 OS=Bos taurus OX=9913 GN=ZNF397 PE=3 SV=1 CANONICAL=A0AAA9SCN5-1" }, "locus": { "chromosome": "24", "start_pos": 21783891, "end_pos": 21783009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088638.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088638.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079666.1" } ] } }, { "isoform_ac": "A0AAA9SCN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5/entry#A0AAA9SCN5-1", "sequence": { "sequence": "MAVESRAVSTPVPQNSQEQELILVKVEESRSWGQKLKQSGSARSCQELFRQQFRKFCYQETPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEEAVTLLEDLEREFDDPGQQVGTGRCDMLWEKECTDSSMWHHHKNGVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPCLPPKSVSNKQGPQSPKDERRQPVLEISGCENNESAIKKDISGEKSQRLSQEPSFGGFSEHKSSLEWQQGSAPGETLRRSPSQRASFSPVIFTHKLLANRDHPEPQRNLILSTNSVTYQKVPTEERPYRCDICGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGEKPYECNECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGEEAYICSECGKAFRHRSVLTRHQRVHTVK", "length": 582, "header": "tr|A0AAA9SCN5-1|A0AAA9SCN5_BOVIN Isoform 1 of Zinc finger protein 397 OS=Bos taurus OX=9913 GN=ZNF397 PE=3 SV=1 CANONICAL=A0AAA9SCN5-1" }, "locus": { "chromosome": "24", "start_pos": 21783891, "end_pos": 21779528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129196.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129196.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081287.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081287.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 333, "end_pos": 360, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN5" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 132, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 }, { "start_pos": 399, "end_pos": 401 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAW0-1", "uniprot_ac": "A0AAA9SAW0", "uniprot_id": "A0AAA9SAW0_BOVIN", "mass": { "chemical_mass": 21574.0, "monoisotopic_mass": 21574.0 }, "refseq": {}, "gene_names": [ { "name": "CRYGN", "type": "recommended", "evidence": [ { "id": "A0AAA9SAW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0" } ] } ], "protein_names": [ { "name": "Gamma-crystallin N", "type": "recommended", "evidence": [ { "id": "A0AAA9SAW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0/entry#names_and_taxonomy" } ] }, { "name": "Gamma-N-crystallin", "type": "synonym", "evidence": [ { "id": "A0AAA9SAW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Crystallins are the dominant structural components of the vertebrate eye lens. Also plays an important role for integrity and function of auditory nuclei.", "evidence": [ { "database": "UniProtKB", "id": "E1BDQ1", "url": "https://www.uniprot.org/uniprotkb/E1BDQ1#function" }, { "database": "UniProtKB", "id": "ARBA00055919", "url": "https://www.uniprot.org/uniprotkb/ARBA00055919#function" }, { "database": "UniProtKB", "id": "A0AAA9RSB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSB0#function" }, { "database": "UniProtKB", "id": "A0AAA9SAW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0#function" }, { "database": "UniProtKB", "id": "A0AAA9TV96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV96#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRYGN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0", "locus": { "chromosome": "4", "start_pos": 113974405, "end_pos": 113991343, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003019", "url": "https://www.ensembl.org/id/ENSBTAG00000003019" } ] } } ], "crossref": [ { "id": "A0AAA9SAW0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519041", "url": "https://www.ncbi.nlm.nih.gov/gene/519041", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519041", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519041", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WQAHSAN", "url": "https://omabrowser.org/oma/group/WQAHSAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDQ1", "url": "https://www.orthodb.org/?gene=E1BDQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11818:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11818:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RSB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDQ1", "url": "https://www.uniprot.org/uniprotkb/E1BDQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDQ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGEADTLEITLYEGKHFTGRKLEVFGDCDNFQDHGFMNRVNSVRVESGAWVCFDHPDFRGQQFILEHGDYPDFYRWNGHNDHMGSCRPVRMHGEHFRLEIFEGCNFTGQCLEFKEDCPFLQSRGWTKNCVNAIKAYGDGAWVLYEEPNYRGRMYLVERGDFRSFSDWEAPSARVQSLRRVANF", "length": 184, "header": "tr|A0AAA9SAW0-1|A0AAA9SAW0_BOVIN Isoform 1 of Gamma-crystallin N OS=Bos taurus OX=9913 GN=CRYGN PE=3 SV=1 CANONICAL=A0AAA9SAW0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0/entry#A0AAA9RSB0-1", "sequence": { "sequence": "MAQRSGKITLYEGKHFTGRKLEVFGDCDNFQDHGFMNRVNSVRVESGAWVCFDHPDFRGQQFILEHGDYPDFYRWNGHNDHMGSCRPVRMHGEHFRLEIFEGCNFTGQCLEFKEDCPFLQSRGWTKNCVNAIKAYGDGAWVLYEEPNYRGRMYLVERGDFRSFSDWEAPSARVQSLRRVANF", "length": 182, "header": "tr|A0AAA9RSB0-1|A0AAA9SAW0_BOVIN Computationally mapped isoform of Gamma-crystallin N OS=Bos taurus OX=9913 GN=CRYGN PE=3 SV=1 CANONICAL=A0AAA9SAW0-1" }, "locus": { "chromosome": "4", "start_pos": 113980489, "end_pos": 113974522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098201.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098201.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075396.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075396.1" } ] } }, { "isoform_ac": "A0AAA9SAW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0/entry#A0AAA9SAW0-1", "sequence": { "sequence": "MDGEADTLEITLYEGKHFTGRKLEVFGDCDNFQDHGFMNRVNSVRVESGAWVCFDHPDFRGQQFILEHGDYPDFYRWNGHNDHMGSCRPVRMHGEHFRLEIFEGCNFTGQCLEFKEDCPFLQSRGWTKNCVNAIKAYGDGAWVLYEEPNYRGRMYLVERGDFRSFSDWEAPSARVQSLRRVANF", "length": 184, "header": "tr|A0AAA9SAW0-1|A0AAA9SAW0_BOVIN Isoform 1 of Gamma-crystallin N OS=Bos taurus OX=9913 GN=CRYGN PE=3 SV=1 CANONICAL=A0AAA9SAW0-1" }, "locus": { "chromosome": "4", "start_pos": 113991321, "end_pos": 113974522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095110.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095110.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083236.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083236.1" } ] } }, { "isoform_ac": "A0AAA9TV96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0/entry#A0AAA9TV96-1", "sequence": { "sequence": "MQQITLYEGKHFTGRKLEVFGDCDNFQDHGFMNRVNSVRVESGAWVCFDHPDFRGQQFILEHGDYPDFYRWNGHNDHMGSCRPVRMHGEHFRLEIFEGCNFTGQCLEFKEDCPFLQSRGWTKNCVNAIKAYGDGAWVLYEEPNYRGRMYLVERGDFRSFSDWEAPSARVQSLRRVANF", "length": 178, "header": "tr|A0AAA9TV96-1|A0AAA9TV96_BOVIN Computationally mapped isoform of Gamma-crystallin N OS=Bos taurus OX=9913 GN=CRYGN PE=3 SV=1 CANONICAL=A0AAA9SAW0-1" }, "locus": { "chromosome": "4", "start_pos": 113978595, "end_pos": 113974522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101044.1" } ] } }, { "isoform_ac": "E1BDQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0/entry#E1BDQ1-1", "sequence": { "sequence": "MQITLYEGKHFTGRKLEVFGDCDNFQDHGFMNRVNSVRVESGAWVCFDHPDFRGQQFILEHGDYPDFYRWNGHNDHMGSCRPVRMHGEHFRLEIFEGCNFTGQCLEFKEDCPFLQSRGWTKNCVNAIKAYGDGAWVLYEEPNYRGRMYLVERGDFRSFSDWEAPSARVQSLRRVANF", "length": 177, "header": "tr|E1BDQ1-1|A0AAA9SAW0_BOVIN Computationally mapped isoform of Gamma-crystallin N OS=Bos taurus OX=9913 GN=CRYGN PE=3 SV=3 CANONICAL=A0AAA9SAW0-1" }, "locus": { "chromosome": "4", "start_pos": 113982163, "end_pos": 113974522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003927.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003927.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003927.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003927.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519041", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519041", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A9V8-1", "protein_name": "Crystallin gamma N", "gene_name": "CRYGN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQCSGKITFYEGKCFSGRKLEVCGTCSSFQQRGFPHRVNSIRVQSGAWVCFDHPELHGQQFVLEHGEYPHWQRWNGRGDRMGSCRPVGMVSRGTAVCIPGGARVGLGSLQLRCSAEMGAQVSRCCSLCYGMRPECSDCSFSCLLISPGDISECSGGCHSLWVLFLVVLLTRPRCSQHGQHYRIQLFEGSCFGGRSMELTEDCSCLRGRGWEQPHVNAVRVYGDGAWVLYEEPNYGGRMYVVERGEFGNFRAWQGFSANVQSVRRVINYF", "length": 270 }, "evidence": [ { "id": "A0AAA9SAW0", "url": "https://omabrowser.org/oma/group/A0AAA9SAW0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZEG1-1", "protein_name": "Gamma-crystallin N", "gene_name": "Crygn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQRSGKITLYEGKHFTGRKLEVFGDCDNFQDRGFMNRVNSIRVESGAWVCFDHPDFRGQQFILEHGDYPEFFRWNGHNDHMGSCRPVGMHGEHFRIDIFEGCNFTGQCLEFVEDCPFLQSRGWAKSCVNAIKVYGDGAWVLYEEPNYRGRMYVVERGDFRSFSDWEAHSARVQSLRRVLNFF", "length": 183 }, "evidence": [ { "id": "A0AAA9SAW0", "url": "https://omabrowser.org/oma/group/A0AAA9SAW0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHL5-1", "protein_name": "Gamma-crystallin N", "gene_name": "Crygn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQRSGKITLYEGKHFTGRKLEVFGDCDNFQDQGFMNRVNSIRVESGAWVCFDHPDFRGQQFILEHGDYPEFFRWNGHNDHMGSCRPVGMHGEHFRIDIFEGCNFTGQCLEFVEDCPFLQSRGWAKSCVNAIKVYGDGAWVLYEEPNYRGRMYVLERGDYRCFSDWGAHSARVQSLRRVLNFF", "length": 183 }, "evidence": [ { "id": "A0AAA9SAW0", "url": "https://omabrowser.org/oma/group/A0AAA9SAW0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXF5-1", "protein_name": "Gamma-crystallin N", "gene_name": "CRYGN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQSRGWVKNCVNTIKVYGDGAAWSPRSFGAEDFQLSSSLQSDQGPEEATTKPATTQPPFLTANL", "length": 182 }, "evidence": [ { "id": "A0AAA9SAW0", "url": "https://omabrowser.org/oma/group/A0AAA9SAW0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of eye lens", "id": "GO:0005212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0" } ], "pmid": "" }, { "name": "lens development in camera-type eye", "id": "GO:0002088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAW0" }, { "id": "PS50915", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta/gamma crystallin 'Greek key'", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 48, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAL6-1", "uniprot_ac": "A0AAA9SAL6", "uniprot_id": "A0AAA9SAL6_BOVIN", "mass": { "chemical_mass": 53624.0, "monoisotopic_mass": 53624.0 }, "refseq": {}, "gene_names": [ { "name": "SCTR", "type": "recommended", "evidence": [ { "id": "A0AAA9SAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ] } ], "protein_names": [ { "name": "Secretin receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCTR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6", "locus": { "chromosome": "2", "start_pos": 71244652, "end_pos": 71319499, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013619", "url": "https://www.ensembl.org/id/ENSBTAG00000013619" } ] } } ], "crossref": [ { "id": "A0AAA9SAL6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013619", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013619", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15275", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15275", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047037", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047037", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MJJ2", "url": "https://www.orthodb.org/?gene=F1MJJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RSJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJJ2", "url": "https://www.uniprot.org/uniprotkb/F1MJJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJJ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MJJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPRLPPLPGLLLLACAVHAAWRLDIPDHGWILGRPPSLACSWLPGPHVTFPLTSERVGTPPRLCDVLRVLRVERDQCLQELSRESVEHPAPGCRGLWDNTSCWPSSALGQTVEVACPRFLWMLVGRNGSMFRNCTQGGWSETFPRPDLACGVNVNDSSNEKRYEYLLKLKIMYTVGYSSSLVMLLVALSILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDATHCDAHRVGCKLVMVFFQYCIMANYSWLLVEGLYLHTLLVISFFSERKWLQGFVALGWGSPAIFVASWAVTRHFLEDVGCWDINANASIWWVIRGPVILSILINFILFINILRILMRKLRTQETRGNEVNHYKRLAKSTLLLIPLFGIHYIIFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLRELPLRPVAPSSSFSNGIKASTSEQSRATHRTSVI", "length": 471, "header": "tr|A0AAA9SAL6-1|A0AAA9SAL6_BOVIN Isoform 1 of Secretin receptor OS=Bos taurus OX=9913 GN=SCTR PE=3 SV=1 CANONICAL=A0AAA9SAL6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6/entry#A0AAA9RSJ4-1", "sequence": { "sequence": "MSVGLGTSGSSWSPQTRSREELAEKREGSRVGTPPRLCDVLRVLRVERDQCLQELSRESVEHPAPGCRGLWDNTSCWPSSALGQTVEVACPRFLWMLVGRNGSMFRNCTQGGWSETFPRPDLACGVNVNDSSNEKRYEYLLKLKIMYTVGYSSSLVMLLVALSILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDATHCDAHRVGCKLVMVFFQYCIMANYSWLLVEGLYLHTLLVISFFSERKWLQGFVALGWGSPAIFVASWAVTRHFLEDVGCWDINANASIWWVIRGPVILSILINFILFINILRILMRKLRTQETRGNEVNHYKRLAKSTLLLIPLFGIHYIIFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLRELPLRPVAPSSSFSNGIKASTSEQSRATHRTSVI", "length": 444, "header": "tr|A0AAA9RSJ4-1|A0AAA9SAL6_BOVIN Computationally mapped isoform of Secretin receptor OS=Bos taurus OX=9913 GN=SCTR PE=3 SV=1 CANONICAL=A0AAA9SAL6-1" }, "locus": { "chromosome": "2", "start_pos": 71318685, "end_pos": 71244908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095189.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095189.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075573.1" } ] } }, { "isoform_ac": "A0AAA9SAL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6/entry#A0AAA9SAL6-1", "sequence": { "sequence": "MRPRLPPLPGLLLLACAVHAAWRLDIPDHGWILGRPPSLACSWLPGPHVTFPLTSERVGTPPRLCDVLRVLRVERDQCLQELSRESVEHPAPGCRGLWDNTSCWPSSALGQTVEVACPRFLWMLVGRNGSMFRNCTQGGWSETFPRPDLACGVNVNDSSNEKRYEYLLKLKIMYTVGYSSSLVMLLVALSILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDATHCDAHRVGCKLVMVFFQYCIMANYSWLLVEGLYLHTLLVISFFSERKWLQGFVALGWGSPAIFVASWAVTRHFLEDVGCWDINANASIWWVIRGPVILSILINFILFINILRILMRKLRTQETRGNEVNHYKRLAKSTLLLIPLFGIHYIIFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLRELPLRPVAPSSSFSNGIKASTSEQSRATHRTSVI", "length": 471, "header": "tr|A0AAA9SAL6-1|A0AAA9SAL6_BOVIN Isoform 1 of Secretin receptor OS=Bos taurus OX=9913 GN=SCTR PE=3 SV=1 CANONICAL=A0AAA9SAL6-1" }, "locus": { "chromosome": "2", "start_pos": 71319300, "end_pos": 71244908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135497.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135497.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083133.1" } ] } }, { "isoform_ac": "A0AAA9T3I5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6/entry#A0AAA9T3I5-1", "sequence": { "sequence": "MAMSQGLGHEQYHVELASRPAATNGQPGGCRGLWDNTSCWPSSALGQTVEVACPRFLWMLVGRNGSMFRNCTQGGWSETFPRPDLACGVNVNDSSNEKRYEYLLKLKIMYTVGYSSSLVMLLVALSILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDATHCDAHRVGCKLVMVFFQYCIMANYSWLLVEGLYLHTLLVISFFSERKWLQGFVALGWGSPAIFVASWAVTRHFLEDVGCWDINANASIWWVIRGPVILSILINFILFINILRILMRKLRTQETRGNEVNHYKRLAKSTLLLIPLFGIHYIIFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLRELPLRPVAPSSSFSNGIKASTSEQSRATHRTSVI", "length": 407, "header": "tr|A0AAA9T3I5-1|A0AAA9T3I5_BOVIN Computationally mapped isoform of Secretin receptor OS=Bos taurus OX=9913 GN=SCTR PE=3 SV=1 CANONICAL=A0AAA9SAL6-1" }, "locus": { "chromosome": "2", "start_pos": 71285841, "end_pos": 71244908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127865.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127865.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091034.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091034.1" } ] } }, { "isoform_ac": "F1MJJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6/entry#F1MJJ2-1", "sequence": { "sequence": "MCCGCCGWRGTSACRSSPGRAWSIQPQAAGGYGTTPAAGRPLHWDRQWKWHARGSSGCSWAGMCCRGNPAGSVKRGVQTDSPASRDTLSDNHFWIPGSSMFRNCTQGGWSETFPRPDLACGVNVNDSSNEKRYEYLLKLKIMYTVGYSSSLVMLLVALSILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDATHCDAHRVGCKLVMVFFQYCIMANYSWLLVEGLYLHTLLVISFFSERKWLQGFVALGWGSPAIFVASWAVTRHFLEDVGCWDINANASIWWVIRGPVILSILINFILFINILRILMRKLRTQETRGNEVNHYKRLAKSTLLLIPLFGIHYIIFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWRQWHLRELPLRPVAPSSSFSNGIKASTSEQSRATHRTSVI", "length": 440, "header": "tr|F1MJJ2-1|A0AAA9SAL6_BOVIN Computationally mapped isoform of Secretin receptor OS=Bos taurus OX=9913 GN=SCTR PE=3 SV=3 CANONICAL=A0AAA9SAL6-1" }, "locus": { "chromosome": "2", "start_pos": 71304111, "end_pos": 71244908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018103.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018103.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018103.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018103.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "secretin receptor activity", "id": "GO:0015055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" }, { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" }, { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" }, { "id": "PS50227", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50227" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 1", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 155, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL6" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 170, "end_pos": 420, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 319, "end_pos": 321 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBD1-1", "uniprot_ac": "A0AAA9SBD1", "uniprot_id": "A0AAA9SBD1_BOVIN", "mass": { "chemical_mass": 25454.0, "monoisotopic_mass": 25454.0 }, "refseq": {}, "gene_names": [ { "name": "SSBP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ] } ], "protein_names": [ { "name": "Single-stranded DNA-binding protein, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.", "evidence": [ { "database": "UniProtKB", "id": "F1N1S0", "url": "https://www.uniprot.org/uniprotkb/F1N1S0#function" }, { "database": "UniProtKB", "id": "ARBA00045894", "url": "https://www.uniprot.org/uniprotkb/ARBA00045894#function" }, { "database": "UniProtKB", "id": "A0AAA9RUM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUM4#function" }, { "database": "UniProtKB", "id": "A0AAA9RVX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVX3#function" }, { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1#function" }, { "database": "UniProtKB", "id": "A0AAA9TCB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB2#function" }, { "database": "UniProtKB", "id": "A0AAA9T435", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T435#function" }, { "database": "UniProtKB", "id": "A0ABI0NXV2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXV2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSBP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1", "locus": { "chromosome": "4", "start_pos": 105038909, "end_pos": 105003734, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010931", "url": "https://www.ensembl.org/id/ENSBTAG00000010931" } ] } } ], "crossref": [ { "id": "A0AAA9SBD1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010931", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010931", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04496", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04496", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515765", "url": "https://www.ncbi.nlm.nih.gov/gene/515765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011344", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011344", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1S0", "url": "https://www.orthodb.org/?gene=F1N1S0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10302", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10302", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10302:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10302:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00436", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00436", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9913635", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913635", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RUM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T435", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T435", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T435-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T435-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXV2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXV2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1S0", "url": "https://www.uniprot.org/uniprotkb/F1N1S0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1S0-1", "url": "https://www.uniprot.org/uniprotkb/F1N1S0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GGLILSSFSRGTAILCFAHVAKSWADLGNSSNTVISFHYKVKISAGWLHFHDALRGLSGSSFSRALSPGSTRKRFPAWRLCGPESQVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIADNIIFLSDQIKEKP", "length": 226, "header": "tr|A0AAA9SBD1-1|A0AAA9SBD1_BOVIN Isoform 1 of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#A0AAA9RUM4-1", "sequence": { "sequence": "MFRRPVVQKHHAAAAKSLQSCPTLCDPRDGSPPGWDSPGKNTGVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIADNIIFLSDQIKEKP", "length": 183, "header": "tr|A0AAA9RUM4-1|A0AAA9SBD1_BOVIN Computationally mapped isoform of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105014655, "end_pos": 105004787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120807.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120807.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074636.1" } ] } }, { "isoform_ac": "A0AAA9RVX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#A0AAA9RVX3-1", "sequence": { "sequence": "MFRRPVVQVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIAGKFLQ", "length": 139, "header": "tr|A0AAA9RVX3-1|A0AAA9SBD1_BOVIN Computationally mapped isoform of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105021585, "end_pos": 105004787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075249.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075249.1" } ] } }, { "isoform_ac": "A0AAA9SBD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#A0AAA9SBD1-1", "sequence": { "sequence": "GGLILSSFSRGTAILCFAHVAKSWADLGNSSNTVISFHYKVKISAGWLHFHDALRGLSGSSFSRALSPGSTRKRFPAWRLCGPESQVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIADNIIFLSDQIKEKP", "length": 226, "header": "tr|A0AAA9SBD1-1|A0AAA9SBD1_BOVIN Isoform 1 of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105014655, "end_pos": 105003734, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117773.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117773.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080775.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080775.1" } ] } }, { "isoform_ac": "A0AAA9T435-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#A0AAA9T435-1", "sequence": { "sequence": "SGVSPVVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIAGKALLHSEPVWYLT", "length": 146, "header": "tr|A0AAA9T435-1|A0AAA9T435_BOVIN Computationally mapped isoform of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105011442, "end_pos": 105007489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132074.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132074.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092556.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092556.1" } ] } }, { "isoform_ac": "A0AAA9TCB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#A0AAA9TCB2-1", "sequence": { "sequence": "MFRRPVVQVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIAVKGMVFPEVMYRCESWTVKKNER", "length": 157, "header": "tr|A0AAA9TCB2-1|A0AAA9TCB2_BOVIN Computationally mapped isoform of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105038296, "end_pos": 105004787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134347.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134347.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095696.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095696.1" } ] } }, { "isoform_ac": "A0ABI0NXV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#A0ABI0NXV2-1", "sequence": { "sequence": "MFRRPVVQVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIADNIIFLSDQIKEKP", "length": 148, "header": "tr|A0ABI0NXV2-1|A0ABI0NXV2_BOVIN Computationally mapped isoform of Single-stranded DNA-binding protein OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=1 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105014655, "end_pos": 105004787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141045.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141045.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105713.1" } ] } }, { "isoform_ac": "F1N1S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1/entry#F1N1S0-1", "sequence": { "sequence": "MLLLLSRFSRVRLCATPETAAHQAGILQVLRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGENETYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYVEGKVDYGEYTDKNNVRRQATTIIADNIIFLSDQIKEKP", "length": 168, "header": "tr|F1N1S0-1|A0AAA9SBD1_BOVIN Computationally mapped isoform of Single-stranded DNA-binding protein, mitochondrial OS=Bos taurus OX=9913 GN=SSBP1 PE=3 SV=2 CANONICAL=A0AAA9SBD1-1" }, "locus": { "chromosome": "4", "start_pos": 105014655, "end_pos": 105007119, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014520.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014520.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014520.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014520.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" }, { "id": "R-BTA-9913635", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913635", "resource": "Reactome", "description": "Strand-asynchronous mitochondrial DNA replication" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial DNA replication", "id": "GO:0090297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ], "pmid": "" }, { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 29, "end_pos": 31 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB16-1", "uniprot_ac": "A0AAA9SB16", "uniprot_id": "A0AAA9SB16_BOVIN", "mass": { "chemical_mass": 295779.0, "monoisotopic_mass": 295779.0 }, "refseq": {}, "gene_names": [ { "name": "CEP295", "type": "recommended", "evidence": [ { "id": "A0AAA9SB16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ] } ], "protein_names": [ { "name": "Centrosomal protein 295", "type": "synonym", "evidence": [ { "id": "A0AAA9SB16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP295", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16", "locus": { "chromosome": "29", "start_pos": 1085526, "end_pos": 1145458, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001902", "url": "https://www.ensembl.org/id/ENSBTAG00000001902" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001902", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001902", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR060287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21553", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21553", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21553:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21553:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28375", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28375", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RVC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T014", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T014", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T014-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T014-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK79", "url": "https://www.uniprot.org/uniprotkb/F1MK79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK79-1", "url": "https://www.uniprot.org/uniprotkb/F1MK79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4A0", "url": "https://www.uniprot.org/uniprotkb/F1N4A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4A0-1", "url": "https://www.uniprot.org/uniprotkb/F1N4A0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEVTAARRWPPRSRPNGCSEAAVGRAAGPSVSEPRFLRPGFRLPEPSYLKYYMKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQVVESDMLTIDSGPLTSEDKPLSFSTDSEKEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQQTGVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGSNAKQSGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGETFSRCTAAPESLQEAFIKRKKAFIERSSQRQKEIKDKVHASGYSQTKTITEKTTGSFVSDLKGMSKVRVSLPEDKKTAQPHTHERAVGLYLQLAEMRKQKEDKAKQDAHAQNRARTKEFHKKTLEKLRARNIC", "length": 2613, "header": "tr|A0AAA9SB16-1|A0AAA9SB16_BOVIN Isoform 1 of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=1 CANONICAL=A0AAA9SB16-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#A0AAA9RVC4-1", "sequence": { "sequence": "MTEVTAARRWPPRSRPNGCSEAAVGRAAGPSVSEPRFLRPGFRLPEPSYLKYYMKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQVVESDMLTIDSGPLTSEDKPLSFSTDSEKEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQQTGVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRVDFDFPELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGETFSRCTAAPESLQEAFIKRKKAFIERSSQRQKEIKDKVHASGYSQTKTITEKTTGSFVSDLKGMSKVRVSLPEDKKTAQPHTHERAVGLYLQLAEMRKQKEDKAKQDAHAQNRARTKEFHKKTLEKLRARNIC", "length": 2561, "header": "tr|A0AAA9RVC4-1|A0AAA9SB16_BOVIN Computationally mapped isoform of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=1 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1145365, "end_pos": 1091862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115257.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115257.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074930.1" } ] } }, { "isoform_ac": "A0AAA9SB16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#A0AAA9SB16-1", "sequence": { "sequence": "MTEVTAARRWPPRSRPNGCSEAAVGRAAGPSVSEPRFLRPGFRLPEPSYLKYYMKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQVVESDMLTIDSGPLTSEDKPLSFSTDSEKEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQQTGVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGSNAKQSGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGETFSRCTAAPESLQEAFIKRKKAFIERSSQRQKEIKDKVHASGYSQTKTITEKTTGSFVSDLKGMSKVRVSLPEDKKTAQPHTHERAVGLYLQLAEMRKQKEDKAKQDAHAQNRARTKEFHKKTLEKLRARNIC", "length": 2613, "header": "tr|A0AAA9SB16-1|A0AAA9SB16_BOVIN Isoform 1 of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=1 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1145365, "end_pos": 1091862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120635.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120635.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080656.1" } ] } }, { "isoform_ac": "A0AAA9SSL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#A0AAA9SSL3-1", "sequence": { "sequence": "MTEVTAARRWPPRSRPNGCSEAAVGRAAGPSVSEPRFLRPGFRLPEPSYLKYYMKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQVVESDMLTIDSGPLTSEDKPLSFSTDSEKEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRVDFDFPELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGETFSRCTAAPESLQEAFIKRKKAFIERSSQRQKEIKDKVHASGYSQTKTITEKTTGSFVSDLKGMSKVRVSLPEDKKTAQPHTHERAVGLYLQLAEMRKQKEDKAKQDAHAQNRARTKEFHKKTLEKLRARNIC", "length": 2566, "header": "tr|A0AAA9SSL3-1|A0AAA9SSL3_BOVIN Computationally mapped isoform of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=1 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1145365, "end_pos": 1091862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106245.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106245.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086984.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086984.1" } ] } }, { "isoform_ac": "A0AAA9SYM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#A0AAA9SYM1-1", "sequence": { "sequence": "MTEVTAARRWPPRSRPNGCSEAAVGRAAGPSVSEPRFLRPGFRLPEPSYLKYYMKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQQTGVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRVDFDFPELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGGMCIRLVNPHPFMKT", "length": 2462, "header": "tr|A0AAA9SYM1-1|A0AAA9SYM1_BOVIN Computationally mapped isoform of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=1 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1145365, "end_pos": 1092646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120896.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120896.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088457.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088457.1" } ] } }, { "isoform_ac": "A0AAA9T014-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#A0AAA9T014-1", "sequence": { "sequence": "LQEWLPHLHDQKNIGPADRSNCDDYQLLSEGSNAKQSGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGETFSRCTAAPESLQEAFIKRKKAFIERSSQRQKEIKDKVHASGYSQTKTITEKTTGSFVSDLKGMSKVRVSLPEDKKTAQPHTHERAVGLYLQLAEMRKQKEDKAKQDAHAQNRARTKEFHKKTLEKLRARNIC", "length": 766, "header": "tr|A0AAA9T014-1|A0AAA9T014_BOVIN Computationally mapped isoform of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=1 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1114986, "end_pos": 1091862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100425.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100425.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089725.1" } ] } }, { "isoform_ac": "F1MK79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#F1MK79-1", "sequence": { "sequence": "MTEVTAARRWPPRSRPNGCSEAAVGRAAGPSVSEPRFLRPGFRLPEPSYLKYYMKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQVVESDMLTIDSGPLTSEDKPLSFSTDSEKEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQQTGVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRVDFDFPELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGDYTFN", "length": 2483, "header": "tr|F1MK79-1|A0AAA9SB16_BOVIN Computationally mapped isoform of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=4 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1145365, "end_pos": 1092076, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052635.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052635.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049270.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049270.4" } ] } }, { "isoform_ac": "F1N4A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16/entry#F1N4A0-1", "sequence": { "sequence": "MKMKRKGVNAGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRTEWVESQTQKIKNLEKLYLASLRNMGEGHQQAKENEPDLNALAHRAAERKKKAEMRHKEALKVQKNQKEMLMKQKTWHIKARKEALLVEKERSAKIASLPPPPPALFENVEVKKTNVKTNSSTYHHLCTFVNREVDTKQPDPHLAAEEEAKRLEELQKQAAQEKMEQSEKAHARGFQAMKKIHLAQNQEKLMKELQQLQQEDLARRRLMVARMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKPLPAVIDQIQDEELDLSMEHESLGETENIPMTEAETVHSSEADVPSAVKTHQIPSKILFKKLLNKIRSQKSLWTIKSVSEEEGEMITTVSEAESKALTVESGATVSEDRTLSSGQEQVVESDMLTIDSGPLTSEDKPLSFSTDSEKEQEMKTTQPLIAPSSILLHPQEEAVRVRMAARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQQTGVSTAPTSYTICSDEDRHRQMIHIYQQQLLQQNRFHKQSVETARKRLLEYQTMLRGKYPSMSATPVIPDSVTSVPPPKSERPSVPSEHEDQGQRPKLSPDKQPVQISKLEQDSQVSRQSRFPQRQVETTEALVTSDVLAKQALESEEHQKQLSQTEVQQRDYKLVAKDSQMLSRALSHDKPLTVQDARERAETSGATAFQSLDSQQVFSENNESVSSKLIEPSSFLPLVAEHSFSSLPTKVESGEIQQPSSTASKGVVSVSHSVAGQMQDKSLPFSENIIAQQSNLKALQEQLDLQKEVLRTRQEAQEQLLLCKQKELEGQTGLSIFLPLVPLNSFASLPSAQAESRRIQESSPTNKETGVSSGHPGVPQLQDRLNLKFFQEQLKTQRDSLQARREAQEVLCVHKQNELDGRVWAEQTGSSSLPPQVAQHTFTSLPSAGPQSGKIQDQYSSKTEKEHFSIQTEMPTSQDGSLGFPQQFQPLHDCLKLLQEQLITQRDALQARHEAQVELLSRKQRDLEDAKSVQMSSSFLPVVTQHSLASQVSAKTEPRRIQNFYFSERDSVIPSNNLVMPASQDASLSFPQYSLPRQENLTALHNQSHVQRVILGDKQETQEFVHKQSELEKIFPSEQTGTSLSQGAESERCQEYMSFRSDSTVPLSHWKIPRSQERLLGFSRHTQPLQGNLEGQQEQLDREEEALQFSQRSQGNVSSGQICPSFTPRLGQLSLTSLPSAESREPLSAESESRTPSSRFHIPVLQDRLWKLSQLIQPQQDNLKSLQEQLATQREAIIQSRQEAQQEFLLHKQGEWKGRVSPEQVGTSSFLPQVIQPLAPLPPSKAGRIQEPCSTKSDNIVSSGHSEIPRLPDRLLGLPQPVLPQQDYPVTFQQEHLYAQTNPLPCSEKIQRELVLPRQYTLEGKSPKHFVQPHHGDLKAYQRQLDIQREVQEEFLLQTLSKLEKGVSAEQTTTSSSLSHVALPVADSKGMPKCFPARSDLAVSSSHPEILRPQERPLHLSQAVLPQQDHVSTQLGLQGEVLRFSEKAQEELLRGNHTKLIEGDASGQPVPSLFLPKEREHSFIPLPFAEVKSQNIRELYSAKIECAAPSSASVSPRLQDRILSFSQPIFAQQDNWGLQKQLELQKEVLPFSQKAQEVLLVPTQTALQQQTHKHRETLKDFFKDSQESKPTVENDFETQKLQEWLPHLHDQKNIGPADRSNCDDYQLLSEGVHQDKELGRKSSKPPVVKIRGGLDLNQHELSAIQEVESPTSGRTSILGKPDFYQDRDPLRVSISREQSFLGSPLDRDPFGHLHPVAQENICGDDSDKAVKVKEAVVENYAVLSYAVEREGHTYLDPNVKLDVKAETQEIYHEPLSSITVSTGSFLSYENIDLSLTEPESFPEHVDHREQEPPAGKEEETNVLSSRVPSTQDIYQRQDSQDVHKPLLCAVETLTSGQTHIQQMRDNYINETNLMTEKTDFRVDFDFPELEHNFPNLHRQLFKPLEPHPDFDLLSCFSGISQDSKDFNQRSGSSCESLRATPSPKSMASFTALRRASLHSSNTSLNQQPDPNLACDTAQSFAVEDIEGSEQSFRQLRPEYSSQEGSQHADLPSIFSIEARASSQDVENQNCSSEHELLQNKQKSVHFQLSVGNLQSSVFNSSGEANVFHQLNLQHGTTCGSTSSEWSIKDQPEGRKERLGFEKLSERLDTVLQGQGLTDDKKETCDLNPHIEETDSHLCVRTVEMGTSIQIPYSLTVQNEKCLQDSTMAGIPTIVGNPSQLAQSELFVNSGSFSLQRSIPVWETESGHGIMEEPELTLTSTSDISIAEMDFANLTLEEKRENEAKSCFQVSEFLPLLSETENSDYPAMSEHPLERPTVCGETFSRCTAAPESLQEAFIKRKKAFIERSSQRQKEIKDKVHASGYSQTKTITEKTTGSFVSDLKGMSKVRVSLPEDKKTAQPHTHERAVGLYLQLAEMRKQKEDKAKQDAHAQNRARTKEFHKSTS", "length": 2538, "header": "tr|F1N4A0-1|F1N4A0_BOVIN Computationally mapped isoform of Centrosomal protein 295 OS=Bos taurus OX=9913 GN=CEP295 PE=4 SV=4 CANONICAL=A0AAA9SB16-1" }, "locus": { "chromosome": "29", "start_pos": 1140147, "end_pos": 1085647, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002475.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002475.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002475.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002475.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1877, "start_aa": "Thr", "end_pos": 1877, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1877", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2140, "start_aa": "Thr", "end_pos": 2140, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2140", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of establishment of protein localization", "id": "GO:1904951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904951", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "positive regulation of centriole elongation", "id": "GO:1903724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "positive regulation of centrosome duplication", "id": "GO:0010825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010825", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "regulation of centriole replication", "id": "GO:0046599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046599", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "mitotic spindle microtubule", "id": "GO:1990498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990498", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1199, "end_pos": 1201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1205, "end_pos": 1207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1315, "end_pos": 1317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1655, "end_pos": 1657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2075, "end_pos": 2077, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2161, "end_pos": 2163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2229, "end_pos": 2231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2259, "end_pos": 2261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2432, "end_pos": 2434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 821, "end_pos": 823, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB16" }, { "id": "PF28375", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28375" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centrosomal protein of 295 kDa-like", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 663, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1877, 2140 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1199, "end_pos": 1201 }, { "start_pos": 1205, "end_pos": 1207 }, { "start_pos": 1315, "end_pos": 1317 }, { "start_pos": 1655, "end_pos": 1657 }, { "start_pos": 2075, "end_pos": 2077 }, { "start_pos": 2161, "end_pos": 2163 }, { "start_pos": 2229, "end_pos": 2231 }, { "start_pos": 2259, "end_pos": 2261 }, { "start_pos": 2432, "end_pos": 2434 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 821, "end_pos": 823 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC71-1", "uniprot_ac": "A0AAA9SC71", "uniprot_id": "A0AAA9SC71_BOVIN", "mass": { "chemical_mass": 30348.0, "monoisotopic_mass": 30348.0 }, "refseq": {}, "gene_names": [ { "name": "BCL2L13", "type": "recommended", "evidence": [ { "id": "A0AAA9SC71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71" } ] } ], "protein_names": [ { "name": "BCL2 like 13", "type": "synonym", "evidence": [ { "id": "A0AAA9SC71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL2L13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71", "locus": { "chromosome": "5", "start_pos": 109133400, "end_pos": 109082265, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013956", "url": "https://www.ensembl.org/id/ENSBTAG00000013956" } ] } } ], "crossref": [ { "id": "A0AAA9SC71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013956", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15758", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15758", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15758:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15758:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RW03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNK0", "url": "https://www.uniprot.org/uniprotkb/F1MNK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNK0-1", "url": "https://www.uniprot.org/uniprotkb/F1MNK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSTTVPLGFHYETKYVVLSYLGLLSQEKLQEQPASSPQGVQQDTVSQSLDQEVLLKVKTEIEEELKSLDKEISEAFASTGFDRHTSPVFSPANPDSSVEDCLAHLGEKAAQELRAPLLGALQTLLSRPVTYQAYRECTLETTVHASGWNKILVPLILLRQMLLELTKRGQEPLGALLQFGVTFLEDHAAEYIIQQGGWGTVFNLESEEECPAGAAEDSNDIYILPSDSSTHVSPPESPSTATASWQAESLPVSLSASQSWHTESLPGLGTQEKEGGF", "length": 279, "header": "tr|A0AAA9SC71-1|A0AAA9SC71_BOVIN Isoform 1 of BCL2 like 13 OS=Bos taurus OX=9913 GN=BCL2L13 PE=3 SV=2 CANONICAL=A0AAA9SC71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RW03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71/entry#A0AAA9RW03-1", "sequence": { "sequence": "MASSTTVPLGFHYETKYVVLSYLGLLSQEKLQEQPASSPQGVQQDTVSQSLDQEVLLKVKTEIEEELKSLDKEISEGHRL", "length": 80, "header": "tr|A0AAA9RW03-1|A0AAA9SC71_BOVIN Computationally mapped isoform of BCL2 like 13 OS=Bos taurus OX=9913 GN=BCL2L13 PE=3 SV=1 CANONICAL=A0AAA9SC71-1" }, "locus": { "chromosome": "5", "start_pos": 109131323, "end_pos": 109090655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102820.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102820.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075207.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075207.1" } ] } }, { "isoform_ac": "A0AAA9SC71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71/entry#A0AAA9SC71-1", "sequence": { "sequence": "MASSTTVPLGFHYETKYVVLSYLGLLSQEKLQEQPASSPQGVQQDTVSQSLDQEVLLKVKTEIEEELKSLDKEISEAFASTGFDRHTSPVFSPANPDSSVEDCLAHLGEKAAQELRAPLLGALQTLLSRPVTYQAYRECTLETTVHASGWNKILVPLILLRQMLLELTKRGQEPLGALLQFGVTFLEDHAAEYIIQQGGWGTVFNLESEEECPAGAAEDSNDIYILPSDSSTHVSPPESPSTATASWQAESLPVSLSASQSWHTESLPGLGTQEKEGGF", "length": 279, "header": "tr|A0AAA9SC71-1|A0AAA9SC71_BOVIN Isoform 1 of BCL2 like 13 OS=Bos taurus OX=9913 GN=BCL2L13 PE=3 SV=2 CANONICAL=A0AAA9SC71-1" }, "locus": { "chromosome": "5", "start_pos": 109132098, "end_pos": 109090655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118891.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118891.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083716.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083716.2" } ] } }, { "isoform_ac": "A0AAA9TV39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71/entry#A0AAA9TV39-1", "sequence": { "sequence": "MASSTTVPLGFHYETKYVVLSYLGLLSQEKLQEQPASSPQGVQQDTVSQSLDQEVLLKVKTEIEEELKSLDKEISEAFASTGFDRHTSPVFSPANPDSSVEDCLAHLGEKAAQELRAPLLGALQTLLSRAPSLTWSQRRSAPRVPRRTATTSTFCPATAPRTVPRSRPPR", "length": 170, "header": "tr|A0AAA9TV39-1|A0AAA9TV39_BOVIN Computationally mapped isoform of BCL2 like 13 OS=Bos taurus OX=9913 GN=BCL2L13 PE=4 SV=2 CANONICAL=A0AAA9SC71-1" }, "locus": { "chromosome": "5", "start_pos": 109131439, "end_pos": 109090655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099730.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099730.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100992.2", "url": "https://www.ensembl.org/id/ENSBTAP00000100992.2" } ] } }, { "isoform_ac": "A0AAA9TYW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71/entry#A0AAA9TYW9-1", "sequence": { "sequence": "MASSTTVPLGFHYETKYVVLSYLGLLSQEKLQEQPASSPQDFGASDFATTNASGADETRPGAAGRAAAVRRDVPGGPRGRVHHPAGWLGHRL", "length": 92, "header": "tr|A0AAA9TYW9-1|A0AAA9TYW9_BOVIN Computationally mapped isoform of BCL2 like 13 OS=Bos taurus OX=9913 GN=BCL2L13 PE=4 SV=1 CANONICAL=A0AAA9SC71-1" }, "locus": { "chromosome": "5", "start_pos": 109131323, "end_pos": 109090655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097700.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097700.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103837.1" } ] } }, { "isoform_ac": "F1MNK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71/entry#F1MNK0-1", "sequence": { "sequence": "MASSTTVPLGFHYETKYVVLSYLGLLSQEKLQEQPASSPQGVQQDTVSQSLDQEVLLKVKTEIEEELKSLDKEISEDFGASDFATTNASGADETRPGAAGRAAAVRRDVPGGPRGRVHHPAGWLGHRL", "length": 128, "header": "tr|F1MNK0-1|A0AAA9SC71_BOVIN Computationally mapped isoform of BCL2 like 13 OS=Bos taurus OX=9913 GN=BCL2L13 PE=3 SV=2 CANONICAL=A0AAA9SC71-1" }, "locus": { "chromosome": "5", "start_pos": 109131323, "end_pos": 109090655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018555.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018555.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018555.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018555.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC71" }, { "id": "PF00452", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00452" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bcl-2 Bcl-2 homology region 1-3", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 200, "start_aa": "Leu", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDK5-1", "uniprot_ac": "A0AAA9SDK5", "uniprot_id": "A0AAA9SDK5_BOVIN", "mass": { "chemical_mass": 99752.0, "monoisotopic_mass": 99752.0 }, "refseq": {}, "gene_names": [ { "name": "PLCD3", "type": "recommended", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] } ], "protein_names": [ { "name": "Phosphoinositide phospholipase C", "type": "recommended", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.11", "type": "synonym", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling.", "evidence": [ { "database": "UniProtKB", "id": "E1BJE0", "url": "https://www.uniprot.org/uniprotkb/E1BJE0#function" }, { "database": "UniProtKB", "id": "ARBA00055041", "url": "https://www.uniprot.org/uniprotkb/ARBA00055041#function" }, { "database": "UniProtKB", "id": "A0AAA9RXG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXG8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLCD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5", "locus": { "chromosome": "19", "start_pos": 44781284, "end_pos": 44802191, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006052", "url": "https://www.ensembl.org/id/ENSBTAG00000006052" } ] } } ], "crossref": [ { "id": "A0AAA9SDK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006052", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006052", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00275", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00275", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08630", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08630", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13363", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13363", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16218", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16218", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJE0", "url": "https://www.orthodb.org/?gene=E1BJE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00387", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00387", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09279", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09279", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855204", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "33179", "url": "https://www.rhea-db.org/rhea/33179", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RXG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE0", "url": "https://www.uniprot.org/uniprotkb/E1BJE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE0-1", "url": "https://www.uniprot.org/uniprotkb/E1BJE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLCGSWRSRRRQPEEPLVPAQVATPVGLASPPASQEGNIKRPGLRALKKMGLSEDEDVRAMLRGSRFCKIRSPTWQKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAIREGHQSEGLRHFGGAFEPARCLTIAFKGRRKNLDLVAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKNLLRMVNLDMNDMYAYGLFKVGTCHHSDLCLPQPWESSVPFPRPRLLWRVASFCRKAASGPYSTLSPREATEPGWEPGPRAPSSPSGRAQECDRSKNERLEGPEIEEFLRRLLKRPELEEIFHRYSGEDRVLSASELLEFLEDQGEHKATLAHAQQLIHTYELNETAKQHELMTLDGFMMYLLSPEGAALDLAHTRVFQDMDQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVREHAFTVSPYPVILSLENHCGLEQQAAMARHLHTILGDMLVTQTLDSQNPEELPSPERLKGRVLVKGKKLPDTRSENGCILSEREEEDEEEDEEEELGAVEQRRRAKQISPELSALAVYCCATRLRTLRPPPVPPQPCQVSSLSERKAKKLIREAGNSFVRHNARHLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYILKPVRLRSPNTTFDPECPGPPRTTLTIQVLTAQQLPKLNTEKPNSIVDPLVRIEIHGVPADCARKKTNYVLNNGFNPRWGQTLEFQLRVPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFVHICIRSRATLGSAGASLCPTPALRSGGRDGGPAPPSSR", "length": 885, "header": "tr|A0AAA9SDK5-1|A0AAA9SDK5_BOVIN Isoform 1 of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCD3 PE=4 SV=1 CANONICAL=A0AAA9SDK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5/entry#A0AAA9RXG8-1", "sequence": { "sequence": "MRKVPQGLSEDEDVRAMLRGSRFCKIRSPTWQKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAIREGHQSEGLRHFGGAFEPARCLTIAFKGRRKNLDLVAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKNLLRMVNLDMNDMYAYGLFKECDRSKNERLEGPEIEEFLRRLLKRPELEEIFHRYSGEDRVLSASELLEFLEDQGEHKATLAHAQQLIHTYELNETAKQHELMTLDGFMMYLLSPEGAALDLAHTRVFQDMDQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVREHAFTVSPYPVILSLENHCGLEQQAAMARHLHTILGDMLVTQTLDSQNPEELPSPERLKGRVLVKGKKLPDTRSENGCILSEREEEDEEEDEEEELGAVEQRRRAKQISPELSALAVYCCATRLRTLRPPPVPPQPCQVSSLSERKAKKLIREAGNSFVRHNARHLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYILKPVRLRSPNTTFDPECPGPPRTTLTIQVLTAQQLPKLNTEKPNSIVDPLVRIEIHGVPADCARKKTNYVLNNGFNPRWGQTLEFQLRVPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFVHICIRSRATLGSAGASLCPTPALRSGGRDGGPAPPSSR", "length": 771, "header": "tr|A0AAA9RXG8-1|A0AAA9SDK5_BOVIN Computationally mapped isoform of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCD3 PE=4 SV=1 CANONICAL=A0AAA9SDK5-1" }, "locus": { "chromosome": "19", "start_pos": 44792365, "end_pos": 44781738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107970.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107970.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078203.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078203.1" } ] } }, { "isoform_ac": "A0AAA9SDK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5/entry#A0AAA9SDK5-1", "sequence": { "sequence": "MLCGSWRSRRRQPEEPLVPAQVATPVGLASPPASQEGNIKRPGLRALKKMGLSEDEDVRAMLRGSRFCKIRSPTWQKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAIREGHQSEGLRHFGGAFEPARCLTIAFKGRRKNLDLVAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKNLLRMVNLDMNDMYAYGLFKVGTCHHSDLCLPQPWESSVPFPRPRLLWRVASFCRKAASGPYSTLSPREATEPGWEPGPRAPSSPSGRAQECDRSKNERLEGPEIEEFLRRLLKRPELEEIFHRYSGEDRVLSASELLEFLEDQGEHKATLAHAQQLIHTYELNETAKQHELMTLDGFMMYLLSPEGAALDLAHTRVFQDMDQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVREHAFTVSPYPVILSLENHCGLEQQAAMARHLHTILGDMLVTQTLDSQNPEELPSPERLKGRVLVKGKKLPDTRSENGCILSEREEEDEEEDEEEELGAVEQRRRAKQISPELSALAVYCCATRLRTLRPPPVPPQPCQVSSLSERKAKKLIREAGNSFVRHNARHLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYILKPVRLRSPNTTFDPECPGPPRTTLTIQVLTAQQLPKLNTEKPNSIVDPLVRIEIHGVPADCARKKTNYVLNNGFNPRWGQTLEFQLRVPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFVHICIRSRATLGSAGASLCPTPALRSGGRDGGPAPPSSR", "length": 885, "header": "tr|A0AAA9SDK5-1|A0AAA9SDK5_BOVIN Isoform 1 of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCD3 PE=4 SV=1 CANONICAL=A0AAA9SDK5-1" }, "locus": { "chromosome": "19", "start_pos": 44802105, "end_pos": 44781738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081907.1" } ] } }, { "isoform_ac": "E1BJE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5/entry#E1BJE0-1", "sequence": { "sequence": "MLCGSWRSRRRQPEEPLVPAQVATPVGLASPPASQEGNIKRPGLRALKKMGLSEDEDVRAMLRGSRFCKIRSPTWQKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAIREGHQSEGLRHFGGAFEPARCLTIAFKGRRKNLDLVAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKNLLRMVNLDMNDMYAYGLFKECDRSKNERLEGPEIEEFLRRLLKRPELEEIFHRYSGEDRVLSASELLEFLEDQGEHKATLAHAQQLIHTYELNETAKQHELMTLDGFMMYLLSPEGAALDLAHTRVFQDMDQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVREHAFTVSPYPVILSLENHCGLEQQAAMARHLHTILGDMLVTQTLDSQNPEELPSPENFPCVYISPVDSDLLFQVVDKEDPVNTCSTCTSFRLKGRVLVKGKKLPDTRSENGCILSEREEEDEEEDEEEELGAVEQRRRAKQISPELSALAVYCCATRLRTLRPPPVPPQPCQVSSLSERKAKKLIREAGNSFVRHNARHLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYILKPVRLRSPNTTFDPECPGPPRTTLTIQVLTAQQLPKLNTEKPNSIVDPLVRIEIHGVPADCARKKTNYVLNNGFNPRWGQTLEFQLRVPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFVHICIRSRATLGSAGASLCPTPALRSGGRDGGPAPPSSR", "length": 849, "header": "tr|E1BJE0-1|E1BJE0_BOVIN Computationally mapped isoform of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCD3 PE=4 SV=3 CANONICAL=A0AAA9SDK5-1" }, "locus": { "chromosome": "19", "start_pos": 44802105, "end_pos": 44781738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034821.5", "url": "https://www.ensembl.org/id/ENSBTAT00000034821.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034705.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034705.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 867, "start_aa": "Thr", "end_pos": 867, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr867", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1855204", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 712, "end_pos": 714, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33179", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SDK5-1", "A0AAA9S613-1", "G3N0S6-1", "F1MF11-1", "E1BH60-1", "A0A3Q1NG43-1", "P10895-1", "A0AAF6YYJ2-1", "P10894-1", "P21671-1", "P08487-1", "Q07722-1", "Q1RML2-1", "A7MB47-1", "F1MSD7-1", "E1B7M6-1", "A0A3Q1MTC3-1", "A0AAA9SMQ6-1" ], "evidence": [ { "id": "33179", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33179" } ] }, { "id": "R-BTA-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10895-1", "A0A3Q1NG43-1", "A0AAA9S613-1", "F1MF11-1", "A0AAA9SDK5-1" ], "evidence": [ { "id": "R-BTA-1855221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855221" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MTC3", "gene_name": "PLCL1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A3Q1MTC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTC3" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A3Q1MTC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTC3" } ] } ] }, { "uniprot_ac": "A0A3Q1NG43", "gene_name": "PLCE1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A3Q1NG43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG43" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A3Q1NG43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG43" } ] } ] }, { "uniprot_ac": "A0AAA9S613", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9S613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S613" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9S613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S613" } ] } ] }, { "uniprot_ac": "A0AAA9SDK5", "gene_name": "PLCD3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] } ] }, { "uniprot_ac": "A0AAA9SMQ6", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9SMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9SMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ6" } ] } ] }, { "uniprot_ac": "A0AAF6YYJ2", "gene_name": "PLCZ1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAF6YYJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYJ2" } ] } ] }, { "uniprot_ac": "A7MB47", "gene_name": "CNOT9", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A7MB47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB47" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A7MB47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB47" } ] } ] }, { "uniprot_ac": "E1B7M6", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "E1B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "E1B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M6" } ] } ] }, { "uniprot_ac": "E1BH60", "gene_name": "PLCL2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "E1BH60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH60" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "E1BH60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH60" } ] } ] }, { "uniprot_ac": "F1MF11", "gene_name": "PLCH1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "F1MF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1MF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ] } ] }, { "uniprot_ac": "F1MSD7", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "F1MSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1MSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD7" } ] } ] }, { "uniprot_ac": "G3N0S6", "gene_name": "PLCH2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "G3N0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0S6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "G3N0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0S6" } ] } ] }, { "uniprot_ac": "P08487", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P08487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08487" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P08487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08487" } ] } ] }, { "uniprot_ac": "P10894", "gene_name": "PLCB1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10894" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10894" } ] } ] }, { "uniprot_ac": "P10895", "gene_name": "PLCD1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P10895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10895" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10895" } ] } ] }, { "uniprot_ac": "P21671", "gene_name": "PLCD4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "P21671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21671" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P21671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21671" } ] } ] }, { "uniprot_ac": "Q07722", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q07722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07722" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q07722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07722" } ] } ] }, { "uniprot_ac": "Q1RML2", "gene_name": "PLCZ1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "Q1RML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML2" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q1RML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 707, "end_pos": 834, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" }, { "id": "PS50008", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50008" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PI-PLC Y-box", "eco_id": "ECO_0000259", "start_pos": 593, "end_pos": 709, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.4.11", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "3.1.4.11", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11" }, { "id": "3.1.4.11", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.11" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 867 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 368, "end_pos": 370 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 712, "end_pos": 714 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBM0-1", "uniprot_ac": "A0AAA9SBM0", "uniprot_id": "A0AAA9SBM0_BOVIN", "mass": { "chemical_mass": 59862.0, "monoisotopic_mass": 59862.0 }, "refseq": {}, "gene_names": [ { "name": "TSBP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SBM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0" } ] } ], "protein_names": [ { "name": "Testis expressed basic protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SBM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSBP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0", "locus": { "chromosome": "23", "start_pos": 27000146, "end_pos": 26924545, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057407", "url": "https://www.ensembl.org/id/ENSBTAG00000057407" } ] } } ], "crossref": [ { "id": "A0AAA9SBM0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14368", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14368", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14368:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14368:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9RYL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVLEIVLAVILTLLGFAILAILLTRWTRRKQNEIDISRYSSEQSAGLLDYEDDRGFWNLYSTESDISYDNREGYNRNYTPSTSSLAPSQPNIVLPQESVSDTNDLKATPELLPGTVGPIMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYTGPSAEATPHAVTCPPSMLRGLPLAPIRIAQVLTMDSSGKVTLSPMVIFPGYMDGELIKKSDSKAQILKSGSTTKFQSSREENKEELQKKISFTDSDEVVIAEHKRELSNFQDAELQKGKIEMEVKVKDSNAGIPIGQGSQVKKSETRILKGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRILKGQGSQVKKSETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVEKSETRISNGQTAQEKESSEDKEKEDNEKRDTGKDKEENDAKNKNVHGEKDKVQGKNNLTIKDKKVETSQRAKPSKVVKYNKKEEQ", "length": 544, "header": "tr|A0AAA9SBM0-1|A0AAA9SBM0_BOVIN Isoform 1 of Testis expressed basic protein 1 OS=Bos taurus OX=9913 GN=TSBP1 PE=4 SV=1 CANONICAL=A0AAA9SBM0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0/entry#A0AAA9RYL6-1", "sequence": { "sequence": "MAVLEIVLAVILTLLGFAILAILLTRWTRRKQNEIDISRYSSEQSAGLLDYEDDRGFWNLYSTESEGYNRNYTPSTSSLAPSQPNIVLPQESVSDTNDLKATPELLPGTVGPIMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYTGPSACPPSMLRGLPLAPIRIAQVLTMDSSGKVTLSPMVIFPGYMDGELIKKSDSKAQILKSGSTTKFQSSREENKEELQKKISFTDSDEVVIAEHKRELSNFQDAELQKGKIEMEVKVKDSNAGIPIGQGSQVKKSETRILKGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRILKGQGSQVKKSETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVEKSETRISNGQTAQEKESSEDKEKEDNEKRDTGKDKEENDAKNKNVHGEKDKVQGKNNLTIKDKKVETSQRAKPSKVVKYNKKEEQ", "length": 529, "header": "tr|A0AAA9RYL6-1|A0AAA9SBM0_BOVIN Computationally mapped isoform of Testis expressed basic protein 1 OS=Bos taurus OX=9913 GN=TSBP1 PE=4 SV=1 CANONICAL=A0AAA9SBM0-1" }, "locus": { "chromosome": "23", "start_pos": 26992537, "end_pos": 26924545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107888.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107888.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077698.1" } ] } }, { "isoform_ac": "A0AAA9SBM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0/entry#A0AAA9SBM0-1", "sequence": { "sequence": "MAVLEIVLAVILTLLGFAILAILLTRWTRRKQNEIDISRYSSEQSAGLLDYEDDRGFWNLYSTESDISYDNREGYNRNYTPSTSSLAPSQPNIVLPQESVSDTNDLKATPELLPGTVGPIMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYTGPSAEATPHAVTCPPSMLRGLPLAPIRIAQVLTMDSSGKVTLSPMVIFPGYMDGELIKKSDSKAQILKSGSTTKFQSSREENKEELQKKISFTDSDEVVIAEHKRELSNFQDAELQKGKIEMEVKVKDSNAGIPIGQGSQVKKSETRILKGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRILKGQGSQVKKSETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVEKSETRISNGQTAQEKESSEDKEKEDNEKRDTGKDKEENDAKNKNVHGEKDKVQGKNNLTIKDKKVETSQRAKPSKVVKYNKKEEQ", "length": 544, "header": "tr|A0AAA9SBM0-1|A0AAA9SBM0_BOVIN Isoform 1 of Testis expressed basic protein 1 OS=Bos taurus OX=9913 GN=TSBP1 PE=4 SV=1 CANONICAL=A0AAA9SBM0-1" }, "locus": { "chromosome": "23", "start_pos": 26992537, "end_pos": 26924545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096577.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096577.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079615.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079615.1" } ] } }, { "isoform_ac": "A0AAA9TUV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0/entry#A0AAA9TUV4-1", "sequence": { "sequence": "MAVLEIVLAVILTLLGFAILAILLTRWTRRKQNEIDISRYSSEQSAGLLDYEDDRGFWNLYSTESDISYDNREGYNRNYTPSTSSLAPSQPNIVLPQESVSDTNDLKATPELLPGTVGPIMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYTGPSACPPSMLRGLPLAPIMISQRTSRIAQVLTMDSSGKVTLSPMVIFPGYMDGELIKKSDSKAQILKSGSTTKFQSSREENKEELQKKISFTDSDEVVIAEHKRELSNFQDAELQKGKIEMEVKVKDSNAGIPIGQGSQVKKSETRILKGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRILKGQGSQVKKSETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVEKSETRISNGQTAQEKESSEDKEKEDNEKRDTGKDKEENDAKNKNVHGEKDKVQGKNNLTIKDKKVETSQRAKPSKVVKYNKKEEQ", "length": 543, "header": "tr|A0AAA9TUV4-1|A0AAA9TUV4_BOVIN Computationally mapped isoform of Testis expressed basic protein 1 OS=Bos taurus OX=9913 GN=TSBP1 PE=4 SV=1 CANONICAL=A0AAA9SBM0-1" }, "locus": { "chromosome": "23", "start_pos": 26992537, "end_pos": 26924545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107271.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107271.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102405.1" } ] } }, { "isoform_ac": "A0AAA9TZ85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBM0/entry#A0AAA9TZ85-1", "sequence": { "sequence": "MAVLEIVLAVILTLLGFAILAILLTRWTRRKQNEIDISRYSSEQSAGLLDYEDDRGFWNLYSTESEGYNRNYTPSTSSLAPSQPNIVLPQESVSDTNDLKATPELLPGTVGPIMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYTGPSACPPSMLRGLPLAPIMISQRTSRIAQVLTMDSSGKVTLSPMVIFPGYMDGELIKKSDSKAQILKSGSTTKFQSSREENKEELQKKISFTDSDEVVIAEHKRELSNFQDAELQKGKIEMEVKVKDSNAGIPIGQGSQVKKSETRILKGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRILKGQGSQVKKSETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKNETRIPIGQGSQVKKSETRIPIGQGSQVKKNETRIPIGQGSQVKKSECLRNILIYHH", "length": 449, "header": "tr|A0AAA9TZ85-1|A0AAA9TZ85_BOVIN Computationally mapped isoform of Testis expressed basic protein 1 OS=Bos taurus OX=9913 GN=TSBP1 PE=4 SV=1 CANONICAL=A0AAA9SBM0-1" }, "locus": { "chromosome": "23", "start_pos": 27000146, "end_pos": 26924545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107781.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107781.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102026.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 311, "end_pos": 313 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 386, "end_pos": 388 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAD1-1", "uniprot_ac": "A0AAA9SAD1", "uniprot_id": "A0AAA9SAD1_BOVIN", "mass": { "chemical_mass": 118607.0, "monoisotopic_mass": 118607.0 }, "refseq": { "ac": "XP_005209910", "name": "E3 ubiquitin-protein ligase Topors isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209910" }, "gene_names": [ { "name": "TOPORS", "type": "recommended", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ] }, { "name": "TOPORS", "type": "synonym", "evidence": [ { "id": "XP_005209910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209910" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase Topors", "type": "recommended", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase Topors isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209910" } ] }, { "name": "RING-type E3 ubiquitin transferase Topors", "type": "synonym", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] }, { "name": "SUMO1-protein E3 ligase Topors", "type": "synonym", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] }, { "name": "Topoisomerase I-binding RING finger protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] }, { "name": "Topoisomerase I-binding arginine/serine-rich protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] }, { "name": "Tumor suppressor p53-binding protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOPORS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1", "locus": { "chromosome": "8", "start_pos": 11533039, "end_pos": 11522164, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005905", "url": "https://www.ensembl.org/id/ENSBTAG00000005905" } ] } } ], "crossref": [ { "id": "A0AAA9SAD1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005905", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005905", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16574", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16574", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523321", "url": "https://www.ncbi.nlm.nih.gov/gene/523321", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523321", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523321", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DCVIVGF", "url": "https://omabrowser.org/oma/group/DCVIVGF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N329", "url": "https://www.orthodb.org/?gene=F1N329", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46077", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46077", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46077:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46077:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4085377", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085377", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4755510", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4755510", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005209910", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209910", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N329", "url": "https://www.uniprot.org/uniprotkb/F1N329", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N329-1", "url": "https://www.uniprot.org/uniprotkb/F1N329-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRDKGSQQPPGSPLSREEGEAPRPTPAPEGRRRSRRVRLRGSCRHRPSLLGRRELATSAPVRPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFATPEVRRFRYRTTMTRERSASVHSPSSTVNRRTTTPPDSGVLFEGLSISARPRDGEIPPFMRQISVRRPTTTDERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDVNVATVSQAPWDDETPGPSYSSSEQVHAAMSSLLNTSDSSDEELVTARATSQIQGVQTNEDLNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEVELGSYEKMETMKTQEQEQSYSSGDSDVSRCSSPRSVVGKDEQINKGRCDSGTKINSKKEEKRSISLSSLRDLSSSLRGDRVYSPYTRRHRKRGRSRSSDSYSQSRSGHDQKNRRKHHGKKRMKGKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESSSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPELRIQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSKTASTGPDRVRNEKPGGKRKYKTRHLEGTNDVAQPCHEFASKVKEGHYSKSSSKLDGGYKNESDSFSDSRSSDRETKHKRRKRRTRSLSVEIVYEGKATDTTRHHKKKKKKHKRKHKRHHGDNASHSPVVITIDSDSDKDCEVKEDIECDPSGPQGPLQSEVLAPFESKDVVTIEDEFGVLSKECDITILNNNLNNANKTVDNISPQAASIGQTLDVREESTLASDLENQPSTVSFQTEPSRTSSLMSVSLGRDHDVS", "length": 1040, "header": "tr|A0AAA9SAD1-1|A0AAA9SAD1_BOVIN Isoform 1 of E3 ubiquitin-protein ligase Topors OS=Bos taurus OX=9913 GN=TOPORS PE=4 SV=1 CANONICAL=A0AAA9SAD1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#A0AAA9RYM4-1", "sequence": { "sequence": "MASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFATPEVRRFRYRTTMTRERSASVHSPSSTVNRRTTTPPDSGVLFEGLSISARPRDGEIPPFMRQISVRRPTTTDERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDVNVATVSQAPWDDETPGPSYSSSEQVHAAMSSLLNTSDSSDEELVTARATSQIQGVQTNEDLNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEVELGSYEKMETMKTQEQEQSYSSGDSDVSRCSSPRSVVGKDEQINKGRCDSGTKINSKKEEKRSISLSSLRDLSSSLRGDRVYSPYTRRHRKRGRSRSSDSYSQSRSGHDQKNRRKHHGKKRMKGKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESSSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPELRIQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSKTASTGPDRVRNEKPGGKRKYKTRHLEGTNDVAQPCHEFASKVKEGHYSKSSSKLDGGYKNESDSFSDSRSSDRETKHKRRKRRTRSLSVEIVYEGKATDTTRHHKKKKKKHKRKHKRHHGDNASHSPVVITIDSDSDKDCEVKEDIECDPSGPQGPLQSEVLAPFESKDVVTIEDEFGVLSKECDITILNNNLNNANKTVDNISPQAASIGQTLDVREESTLASDLENQPSTVSFQTEPSRTSSLMSVSLGRDHDVS", "length": 970, "header": "tr|A0AAA9RYM4-1|A0AAA9SAD1_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase Topors OS=Bos taurus OX=9913 GN=TOPORS PE=4 SV=1 CANONICAL=A0AAA9SAD1-1" }, "locus": { "chromosome": "8", "start_pos": 11532296, "end_pos": 11529387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117727.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117727.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076376.1" } ] } }, { "isoform_ac": "A0AAA9SAD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#A0AAA9SAD1-1", "sequence": { "sequence": "MRDKGSQQPPGSPLSREEGEAPRPTPAPEGRRRSRRVRLRGSCRHRPSLLGRRELATSAPVRPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFATPEVRRFRYRTTMTRERSASVHSPSSTVNRRTTTPPDSGVLFEGLSISARPRDGEIPPFMRQISVRRPTTTDERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDVNVATVSQAPWDDETPGPSYSSSEQVHAAMSSLLNTSDSSDEELVTARATSQIQGVQTNEDLNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEVELGSYEKMETMKTQEQEQSYSSGDSDVSRCSSPRSVVGKDEQINKGRCDSGTKINSKKEEKRSISLSSLRDLSSSLRGDRVYSPYTRRHRKRGRSRSSDSYSQSRSGHDQKNRRKHHGKKRMKGKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESSSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPELRIQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSKTASTGPDRVRNEKPGGKRKYKTRHLEGTNDVAQPCHEFASKVKEGHYSKSSSKLDGGYKNESDSFSDSRSSDRETKHKRRKRRTRSLSVEIVYEGKATDTTRHHKKKKKKHKRKHKRHHGDNASHSPVVITIDSDSDKDCEVKEDIECDPSGPQGPLQSEVLAPFESKDVVTIEDEFGVLSKECDITILNNNLNNANKTVDNISPQAASIGQTLDVREESTLASDLENQPSTVSFQTEPSRTSSLMSVSLGRDHDVS", "length": 1040, "header": "tr|A0AAA9SAD1-1|A0AAA9SAD1_BOVIN Isoform 1 of E3 ubiquitin-protein ligase Topors OS=Bos taurus OX=9913 GN=TOPORS PE=4 SV=1 CANONICAL=A0AAA9SAD1-1" }, "locus": { "chromosome": "8", "start_pos": 11532296, "end_pos": 11522546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118216.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118216.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080388.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080388.1" } ] } }, { "isoform_ac": "F1N329-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1/entry#F1N329-1", "sequence": { "sequence": "MGSQQPPGSPLSREEGEAPRPTPAPEGRRRSRRVRLRGSCRHRPSLLGRRELATSAPVRPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFATPEVRRFRYRTTMTRERSASVHSPSSTVNRRTTTPPDSGVLFEGLSISARPRDGEIPPFMRQISVRRPTTTDERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDVNVATVSQAPWDDETPGPSYSSSEQVHAAMSSLLNTSDSSDEELVTARATSQIQGVQTNEDLNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEVELGSYEKMETMKTQEQEQSYSSGDSDVSRCSSPRSVVGKDEQINKGRCDSGTKINSKKEEKRSISLSSLRDLSSSLRGDRVYSPYTRRHRKRGRSRSSDSYSQSRSGHDQKNRRKHHGKKRMKGKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESSSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPELRIQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSKTASTGPDRVRNEKPGGKRKYKTRHLEGTNDVAQPCHEFASKVKEGHYSKSSSKLDGGYKNESDSFSDSRSSDRETKHKRRKRRTRSLSVEIVYEGKATDTTRHHKKKKKKHKRKHKRHHGDNASHSPVVITIDSDSDKDCEVKEDIECDPSGPQGPLQSEVLAPFESKDVVTIEDEFGVLSKECDITILNNNLNNANKTVDNISPQAASIGQTLDVREESTLASDLENQPSTVSFQTEPSRTSSLMSVSLGRDHDVS", "length": 1037, "header": "tr|F1N329-1|F1N329_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase Topors OS=Bos taurus OX=9913 GN=TOPORS PE=4 SV=3 CANONICAL=A0AAA9SAD1-1" }, "locus": { "chromosome": "8", "start_pos": 11532296, "end_pos": 11522213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048966.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048966.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045917.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045917.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523321", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523321", "resource": "KEGG Pathway" }, { "id": "R-BTA-3899300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "resource": "Reactome", "description": "SUMOylation of transcription cofactors" }, { "id": "R-BTA-4085377", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085377", "resource": "Reactome", "description": "SUMOylation of SUMOylation proteins" }, { "id": "R-BTA-4755510", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4755510", "resource": "Reactome", "description": "SUMOylation of immune response proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M1P6B6-1", "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "toporsa", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASPQIKERPSGVVLNTISKGASPESKCPICLDHFKNISYLDVCLHKFCFCCIHEWSKNKAECPLCKQPFNSFYHTIKSEDDYKRFDLRPTENGSFGNMAGQRFRYRTTLTGDRRPVQRRTSPPPDHGIIFEGLRGSLPQRHNRDLHSMIRRLTVRQRRESEGRSLRSLQDQEVVKFRRALYRRGVQVQSVQDGGRTRETSAEFFKRNPACLHRLVPWLRRELTVLYGAHGSLVNIVQHIIMTLITRHNLDDQAVQHELRPFLLSHTEHFLHEFLSFARSPFNMEAYDQRAVYDLPRPSGESSSSENSVIAISEDESESLVSGAQDFATPRVTSSQTAWDDETPGPSYSSERSQVLPVHVRDSDSDSSVGEAVMPIAAVRHQDHPANPSTIQPEEDHSSSNDEDCVIIGYVKPVAERTPELVQLSSDSENSETEQNASPRNSQAPQHIRFISDSDASPTASQRPLRGPASSSRSFEDTSIQLRKNSKYDNTFSGSREGSSQSKRIHSSSHRKKQPLCKESKNKQRGEKETSRHSSSYWHSYSYYSHDNSRKAYTETSSSYTSYYRSVNDQFGSRSHGKRRCRDLLDRSRSRSNSRISQSNRRNRSRSRSNSRISRSNQRNRSHSRSNSGKSQSNRRNRSCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNQRNRRHSRSNSRISQSSRQNRSLSRSNSRKGYSNRRNRNHSRSSSRVSQSSQRNRSHSRSNFRIKSSSYKSQDEKYQRSLSRSLYSNNDVRSRSRSSSRINTSSRQDRRRSRSSSRMNSSSSRQTSCHDKYGKKRMYKTKHHEKPSRQSSSKSVGDSDEVGGKKKKKKHTKRRKTRSPSIDDRSEGHSQRHHKRKKKHKKKSKRHNSKERTRKLSPVLITITTDSDGESADPSEPSTSSVCAIRSTVLIANMATEAFLDNEHQSTAGTENSSVGDAGNYP", "length": 999 }, "evidence": [ { "id": "A0AAA9SAD1", "url": "https://omabrowser.org/oma/group/A0AAA9SAD1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XIL9-1", "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "TOPORS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSELPRGVAKATRRRRHPAGEERRDGPGNICSRPRHGLKTPSSRTRTRSEGSAEVSAVVGPANTTNAAREFSEDSSFLPKASNSKLHQTMPTDASPDSKCPICLDRFDNVAYLDRCLHRFCFRCVQEWSKNKAECPLCKQPFFSIFHTVRAEDDFKEYILRPSENGSFASPDGRRFRYRTTLTRERRTSSYHRGNSSSRRTLSPPDNGILFEGLSSQPVRQRDGEIQQMIRRLASRRQASAEGRSLRQIQEEDMINFRRALYRTGVRVRSIQDGGRYRDISAEFFRHNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFADDLKPFLLNRTEHFLHEFISFARCPFNLEAYDQHVNYDCPAPSYDEGSRSDSSIITISPDEADPQGPEHSSSMSGVGQAPWDDETPGPSYSISEEVRATVASPLEMSESSDEDSARKRTTLRPQLQAGVDSNESDSSSDNCVIIGYVKPLAERTPELVELSSDSEESIREEKREDVKKEQSIQARSWSDSEPSRASSPRSPLYKENVSSCRSSLSSAVEKTESKADDKNKDKVKDLSPHNSVWSPFPETDTTSSPYRKNRSKVKNLSPLDSIRSLSPETDTVCSPYSKNKGKVKDLSPLDSVRSLSPEMGTVCSPYSQRLPRRRKTRSPQTYSQKSRDSHGHRSRREHPSKCQSKKRRSRSRDGSEYSSKRSRRRSRTCDTSLSLKSQRGSLSRESTTSREVSRSRSRSKGHGKRRSRSRDSDYYYRRDNYQSRYQWGYAFYSRKTVGDGSSCRKRTQSKAHYSRQSASPEFRIQSFTERTDPHSQRGLHERHYYYYERCRSRSRSSTRSRTPSGGTDRLKSEKPGGKRKYKTRHLENAVKESTSMEREKDPKKTFSKFRDCCKNEDSLSDNQVSSETKHKKKKKKMRSPSVEIVYEGKVTDTMKHAKKKKKKHKKKHRKHHMSNSAHSSPVVITIDSDSSKEPESTECDSSVTWTGTTHLNERECESPSSFLGITGCEDVYRVSKETRGVVKKYSIPTRGRDLDGDITNAGAELVEATERADRSIDLADTASGNTETVVSQEAQAAPSSQLSSPRTSLLGHPERPPLILRLPKRLVNRSCWFESLEKNM", "length": 1126 }, "evidence": [ { "id": "A0AAA9SAD1", "url": "https://omabrowser.org/oma/group/A0AAA9SAD1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q80Z37-1", "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "Topors", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQPPPPGSPLSREEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYSPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSSDSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHGKKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTRHLEGTSEEAQPAREFTSKGKDSHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVKAGIECSNGSLPQPIQDGAFETKDVVTIEDELGVLDKDCDVTALADDLSTSQTVENCDSPAVPVEQTLDVREESTFASDLESQSSNVSIQAEPSRPVPSPRTSLSSVSPGRDCDVS", "length": 1033 }, "evidence": [ { "id": "A0AAA9SAD1", "url": "https://omabrowser.org/oma/group/A0AAA9SAD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NS56-1", "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "TOPORS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS", "length": 1045 }, "evidence": [ { "id": "A0AAA9SAD1", "url": "https://omabrowser.org/oma/group/A0AAA9SAD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "SUMO transferase activity", "id": "GO:0019789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "DNA topoisomerase binding", "id": "GO:0044547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044547", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "antigen binding", "id": "GO:0003823", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003823", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:0008630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "protein sumoylation", "id": "GO:0016925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "maintenance of protein location in nucleus", "id": "GO:0051457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "gamma-tubulin complex", "id": "GO:0000930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 760, "end_pos": 762, "annotation": "n_glycosylation_sequon" }, { "start_pos": 780, "end_pos": 782, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 905, "end_pos": 907, "annotation": "n_glycosylation_sequon" }, { "start_pos": 980, "end_pos": 982, "annotation": "n_glycosylation_sequon" }, { "start_pos": 985, "end_pos": 987, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-351657" ], "output_participant_list": [ "R-BTA-4086071" ], "enzyme_list": [ "A0AAA9SAD1-1" ], "evidence": [ { "id": "R-BTA-4085994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085994" } ] }, { "id": "R-BTA-4551683", "name": "SUMOylation of TOPORS with SUMO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-2993791" ], "output_participant_list": [ "R-BTA-4551754" ], "enzyme_list": [ "A0AAA9SAD1-1" ], "evidence": [ { "id": "R-BTA-4551683", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551683" } ] }, { "id": "R-BTA-4755478", "name": "TOPORS SUMOylates IKBKE with SUMO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-4755521" ], "output_participant_list": [ "R-BTA-4755535" ], "enzyme_list": [ "F1MQ36-1", "A0AAA9SAD1-1" ], "evidence": [ { "id": "R-BTA-4755478", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4755478" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-2993791", "participant_name": "TOPORS [nucleoplasm]", "crossref": [ { "id": "F1N329", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000005905", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000045917", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000048966", "database": "ENSEMBL", "url": "" }, { "id": "NP_001179507.2", "database": "RefSeq", "url": "" }, { "id": "36222", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-351657", "participant_name": "SIN3A [nucleoplasm]", "crossref": [ { "id": "F1MTR3", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000009985", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000013167", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000013167", "database": "ENSEMBL", "url": "" }, { "id": "34624", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-4086071", "participant_name": "SIN3A [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000013167", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000009985", "database": "ENSEMBL", "url": "" }, { "id": "34624", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000013167", "database": "ENSEMBL", "url": "" }, { "id": "F1MTR3", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-BTA-4551754", "participant_name": "TOPORS [nucleoplasm]", "crossref": [ { "id": "ENSBTAP00000045917", "database": "ENSEMBL", "url": "" }, { "id": "NP_001179507.2", "database": "RefSeq", "url": "" }, { "id": "F1N329", "database": "UniProt", "url": "" }, { "id": "36222", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000048966", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000005905", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-4755521", "participant_name": "phospho-p-S172-IKBKE [nucleoplasm]", "crossref": [ { "id": "F1MQ36", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000010408", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000013738", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000013738", "database": "ENSEMBL", "url": "" }, { "id": "30101", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-4755535", "participant_name": "phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000013738", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000010408", "database": "ENSEMBL", "url": "" }, { "id": "F1MQ36", "database": "UniProt", "url": "" }, { "id": "30101", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000013738", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SAD1", "gene_name": "TOPORS", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" } ] } ] }, { "uniprot_ac": "F1MQ36", "gene_name": "IKBKE", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ36" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "F1MQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ36" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAD1" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 106, "end_pos": 145, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 444, "end_pos": 446 }, { "start_pos": 473, "end_pos": 475 }, { "start_pos": 760, "end_pos": 762 }, { "start_pos": 780, "end_pos": 782 }, { "start_pos": 82, "end_pos": 84 }, { "start_pos": 843, "end_pos": 845 }, { "start_pos": 905, "end_pos": 907 }, { "start_pos": 980, "end_pos": 982 }, { "start_pos": 985, "end_pos": 987 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCH8-1", "uniprot_ac": "A0AAA9SCH8", "uniprot_id": "A0AAA9SCH8_BOVIN", "mass": { "chemical_mass": 58508.0, "monoisotopic_mass": 58508.0 }, "refseq": {}, "gene_names": [ { "name": "CDCA7", "type": "recommended", "evidence": [ { "id": "A0AAA9SCH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ] } ], "protein_names": [ { "name": "Cell division cycle associated 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SCH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDCA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8", "locus": { "chromosome": "2", "start_pos": 23340522, "end_pos": 23377081, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003458", "url": "https://www.ensembl.org/id/ENSBTAG00000003458" } ] } } ], "crossref": [ { "id": "A0AAA9SCH8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "614893", "url": "https://www.ncbi.nlm.nih.gov/gene/614893", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31169:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31169:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10497", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10497", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RZU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U086", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U086", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U086-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U086-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL92", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YL92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YL92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDSVRPPRRQPTRLPPPWDSPRKNTGVGCHFLRQCVKVKSESEVAQSCPTLSDPMDCSPPGSSIHGIFQQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 516, "header": "tr|A0AAA9SCH8-1|A0AAA9SCH8_BOVIN Isoform 1 of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9RZU9-1", "sequence": { "sequence": "MDARRARRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 332, "header": "tr|A0AAA9RZU9-1|A0AAA9SCH8_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23353591, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104380.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104380.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078183.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078183.1" } ] } }, { "isoform_ac": "A0AAA9SBX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9SBX1-1", "sequence": { "sequence": "MQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 368, "header": "tr|A0AAA9SBX1-1|A0AAA9SBX1_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23376477, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131091.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131091.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082882.1" } ] } }, { "isoform_ac": "A0AAA9SCH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9SCH8-1", "sequence": { "sequence": "MSDSVRPPRRQPTRLPPPWDSPRKNTGVGCHFLRQCVKVKSESEVAQSCPTLSDPMDCSPPGSSIHGIFQQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 516, "header": "tr|A0AAA9SCH8-1|A0AAA9SCH8_BOVIN Isoform 1 of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23361881, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106782.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106782.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079951.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079951.1" } ] } }, { "isoform_ac": "A0AAA9SKD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9SKD9-1", "sequence": { "sequence": "MRLSSSSSSRFDQIYGRPCGNKQVRQLERWGQDSKVQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSKGRRKMRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 409, "header": "tr|A0AAA9SKD9-1|A0AAA9SKD9_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23376882, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110798.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110798.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083075.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083075.1" } ] } }, { "isoform_ac": "A0AAA9SRL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9SRL3-1", "sequence": { "sequence": "MDARRARQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 453, "header": "tr|A0AAA9SRL3-1|A0AAA9SRL3_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23353591, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122122.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122122.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088007.1" } ] } }, { "isoform_ac": "A0AAA9SV37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9SV37-1", "sequence": { "sequence": "MRLSSSSSSRFDQIYGRPCGNKQVRQLERWGQDSKVQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 482, "header": "tr|A0AAA9SV37-1|A0AAA9SV37_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23376882, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110148.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110148.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090333.1" } ] } }, { "isoform_ac": "A0AAA9TMH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9TMH7-1", "sequence": { "sequence": "MDARRARPFLQQQDGALNGTWNVTVYANGNRNGGSAPGEQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 485, "header": "tr|A0AAA9TMH7-1|A0AAA9TMH7_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23353591, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105677.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105677.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098190.1" } ] } }, { "isoform_ac": "A0AAA9U086-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAA9U086-1", "sequence": { "sequence": "MDCSPPGSSIHGIFQQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSESEVQDVLDHCGFLQKPRPDVTNELASIFHADSDDESFCGFSESEIQDGMRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 461, "header": "tr|A0AAA9U086-1|A0AAA9U086_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23356427, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116525.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116525.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103299.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103299.1" } ] } }, { "isoform_ac": "A0AAF6YL92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8/entry#A0AAF6YL92-1", "sequence": { "sequence": "MDARRARQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG", "length": 324, "header": "tr|A0AAF6YL92-1|A0AAF6YL92_BOVIN Computationally mapped isoform of Cell division cycle associated 7 OS=Bos taurus OX=9913 GN=CDCA7 PE=4 SV=1 CANONICAL=A0AAA9SCH8-1" }, "locus": { "chromosome": "2", "start_pos": 23353591, "end_pos": 23341777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004495.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004495.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004495.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004495.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hemi-methylated DNA-binding", "id": "GO:0044729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH8" }, { "id": "PF10497", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10497" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Zinc-finger", "eco_id": "ECO_0000259", "start_pos": 408, "end_pos": 505, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 473, "end_pos": 475 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC48-1", "uniprot_ac": "A0AAA9SC48", "uniprot_id": "A0AAA9SC48_BOVIN", "mass": { "chemical_mass": 30115.0, "monoisotopic_mass": 30115.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101907579", "type": "recommended", "evidence": [ { "id": "A0AAA9SC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48" } ] } ], "protein_names": [ { "name": "Cystatin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101907579", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48", "locus": {} } ], "crossref": [ { "id": "A0AAA9SC48", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC48", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009073", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009073", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101907579", "url": "https://www.ncbi.nlm.nih.gov/gene/101907579", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101907579", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907579", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11414:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11414:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S073", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S073", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S073-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S073-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNI0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXA6", "url": "https://www.uniprot.org/uniprotkb/F1MXA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXA6-1", "url": "https://www.uniprot.org/uniprotkb/F1MXA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LALSQSQGLNSPRLSSVSRPFPVSIRAEDNSCVRTTVGLREGRCTQRGKGPSTAHARSFIPTSPSFFLCFSLPPSLSLFLSSLPLALCSFFLFLLPPPHLSLSLECAFHNGSNPSEGNEHGSCPGEADVLQVTQARANQPTNQLMSKSCIPTILSIHPGRQQPEMGRWERVVRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 274, "header": "tr|A0AAA9SC48-1|A0AAA9SC48_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S073-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#A0AAA9S073-1", "sequence": { "sequence": "MSGALHCIPTILSIHPGRQQPEMGRWERVVRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 132, "header": "tr|A0AAA9S073-1|A0AAA9SC48_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85142248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129397.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129397.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077025.1" } ] } }, { "isoform_ac": "A0AAA9SC48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#A0AAA9SC48-1", "sequence": { "sequence": "LALSQSQGLNSPRLSSVSRPFPVSIRAEDNSCVRTTVGLREGRCTQRGKGPSTAHARSFIPTSPSFFLCFSLPPSLSLFLSSLPLALCSFFLFLLPPPHLSLSLECAFHNGSNPSEGNEHGSCPGEADVLQVTQARANQPTNQLMSKSCIPTILSIHPGRQQPEMGRWERVVRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 274, "header": "tr|A0AAA9SC48-1|A0AAA9SC48_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85138257, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109884.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109884.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081092.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081092.1" } ] } }, { "isoform_ac": "A0AAA9SLA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#A0AAA9SLA6-1", "sequence": { "sequence": "MTGEVEVIKIPQEPCVWCGRQPCKQTITAVCCIPTILSIHPGRQQPEMGRWERVVRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 157, "header": "tr|A0AAA9SLA6-1|A0AAA9SLA6_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85130727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107608.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107608.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084699.1" } ] } }, { "isoform_ac": "A0AAA9SNI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#A0AAA9SNI0-1", "sequence": { "sequence": "MKMGLFCLSDNHQRPPLTSALRLRVCLSFKNQSPGRPLPQPLCSLDLGCCIPTILSIHPGRQQPEMGRWERVVRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 175, "header": "tr|A0AAA9SNI0-1|A0AAA9SNI0_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85141324, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088704.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088704.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084412.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084412.1" } ] } }, { "isoform_ac": "A0AAA9T0R2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#A0AAA9T0R2-1", "sequence": { "sequence": "MSKRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 105, "header": "tr|A0AAA9T0R2-1|A0AAA9T0R2_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85140215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134605.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134605.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090129.1" } ] } }, { "isoform_ac": "A0AAA9T3I9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#A0AAA9T3I9-1", "sequence": { "sequence": "MHAAREGPQHSSCCIPTILSIHPGRQQPEMGRWERVVRPTTEMMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 139, "header": "tr|A0AAA9T3I9-1|A0AAA9T3I9_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=1 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85139195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106353.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106353.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092339.1" } ] } }, { "isoform_ac": "F1MXA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48/entry#F1MXA6-1", "sequence": { "sequence": "MMCGAPPTKQLAAAEIQAIADKVKSPLEEKENKKFLVFNAVEFKSQGVAGRTFFTKVQMDDDFVHIQVFESLPQENKPVALTSYQIHKGRQDEVTCF", "length": 97, "header": "tr|F1MXA6-1|A0AAA9SC48_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC101907579 PE=3 SV=3 CANONICAL=A0AAA9SC48-1" }, "locus": { "chromosome": "8", "start_pos": 85146224, "end_pos": 85145934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089795.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101907579", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907579", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC48" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 178, "end_pos": 274, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBC4-1", "uniprot_ac": "A0AAA9SBC4", "uniprot_id": "A0AAA9SBC4_BOVIN", "mass": { "chemical_mass": 20175.0, "monoisotopic_mass": 20175.0 }, "refseq": {}, "gene_names": [ { "name": "YEATS4", "type": "recommended", "evidence": [ { "id": "A0AAA9SBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ] } ], "protein_names": [ { "name": "YEATS domain containing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1B5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1B5#function" }, { "database": "UniProtKB", "id": "ARBA00057736", "url": "https://www.uniprot.org/uniprotkb/ARBA00057736#function" }, { "database": "UniProtKB", "id": "A0AAA9S8D2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8D2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YEATS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4", "locus": { "chromosome": "5", "start_pos": 44086259, "end_pos": 44110850, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002256", "url": "https://www.ensembl.org/id/ENSBTAG00000002256" } ] } } ], "crossref": [ { "id": "A0AAA9SBC4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBC4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16909", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16909", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47573", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47573", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47573:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47573:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S1B5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1B5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8D2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8D2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQTKEI", "length": 173, "header": "tr|A0AAA9SBC4-1|A0AAA9SBC4_BOVIN Isoform 1 of YEATS domain containing 4 OS=Bos taurus OX=9913 GN=YEATS4 PE=4 SV=1 CANONICAL=A0AAA9SBC4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4/entry#A0AAA9S1B5-1", "sequence": { "sequence": "MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETESAAAAAKSLQLCLTLCDPRDGTPPGSTILGILQARILDCRT", "length": 212, "header": "tr|A0AAA9S1B5-1|A0AAA9SBC4_BOVIN Computationally mapped isoform of YEATS domain containing 4 OS=Bos taurus OX=9913 GN=YEATS4 PE=4 SV=1 CANONICAL=A0AAA9SBC4-1" }, "locus": { "chromosome": "5", "start_pos": 44110582, "end_pos": 44086902, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116017.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116017.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079664.1" } ] } }, { "isoform_ac": "A0AAA9S8D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4/entry#A0AAA9S8D2-1", "sequence": { "sequence": "MDVVAKEEATWRAGRSWLGVHPLPTQGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQTKEI", "length": 236, "header": "tr|A0AAA9S8D2-1|A0AAA9SBC4_BOVIN Computationally mapped isoform of YEATS domain containing 4 OS=Bos taurus OX=9913 GN=YEATS4 PE=4 SV=1 CANONICAL=A0AAA9SBC4-1" }, "locus": { "chromosome": "5", "start_pos": 44110275, "end_pos": 44086745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121122.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121122.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080187.1" } ] } }, { "isoform_ac": "A0AAA9SBC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4/entry#A0AAA9SBC4-1", "sequence": { "sequence": "MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQTKEI", "length": 173, "header": "tr|A0AAA9SBC4-1|A0AAA9SBC4_BOVIN Isoform 1 of YEATS domain containing 4 OS=Bos taurus OX=9913 GN=YEATS4 PE=4 SV=1 CANONICAL=A0AAA9SBC4-1" }, "locus": { "chromosome": "5", "start_pos": 44110582, "end_pos": 44086745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101798.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101798.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082688.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082688.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex", "id": "GO:0035267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via homologous recombination", "id": "GO:1905168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "histone H3K18ac reader activity", "id": "GO:0140044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140044", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" }, { "name": "histone H3K27ac reader activity", "id": "GO:0140119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140119", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBC4" }, { "id": "PS51037", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YEATS", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 173, "start_aa": "Arg", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB04-1", "uniprot_ac": "A0AAA9SB04", "uniprot_id": "A0AAA9SB04_BOVIN", "mass": { "chemical_mass": 68913.0, "monoisotopic_mass": 68913.0 }, "refseq": {}, "gene_names": [ { "name": "EIF2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#names_and_taxonomy" } ] }, { "name": "eIF-2A", "type": "synonym", "evidence": [ { "id": "A0AAA9SB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1S4#function" }, { "database": "UniProtKB", "id": "ARBA00003993", "url": "https://www.uniprot.org/uniprotkb/ARBA00003993#function" }, { "database": "UniProtKB", "id": "PIRNR017222", "url": "https://www.uniprot.org/uniprotkb/PIRNR017222#function" }, { "database": "UniProtKB", "id": "A0AAA9S2G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G9#function" }, { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04#function" }, { "database": "UniProtKB", "id": "A0A3Q1LW11", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW11#function" }, { "database": "UniProtKB", "id": "A0A3Q1M2B7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B7#function" }, { "database": "UniProtKB", "id": "F1MBF0", "url": "https://www.uniprot.org/uniprotkb/F1MBF0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04", "locus": { "chromosome": "1", "start_pos": 117556217, "end_pos": 117597974, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009106", "url": "https://www.ensembl.org/id/ENSBTAG00000009106" } ] } } ], "crossref": [ { "id": "A0AAA9SB04", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009106", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009106", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RCCAYSP", "url": "https://omabrowser.org/oma/group/RCCAYSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LW11", "url": "https://www.orthodb.org/?gene=A0A3Q1LW11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2B7", "url": "https://www.orthodb.org/?gene=A0A3Q1M2B7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MBF0", "url": "https://www.orthodb.org/?gene=F1MBF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13227", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13227", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13227:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13227:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LW11", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW11-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2B7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2B7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBF0", "url": "https://www.uniprot.org/uniprotkb/F1MBF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBF0-1", "url": "https://www.uniprot.org/uniprotkb/F1MBF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKAYTFSKDGTLFAWGNGEKINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTASKDDTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQVFSAFFIWAHSYYHPSPFYYKQLFNQIKEYIDFKTSFEIRKDRGIRGSW", "length": 613, "header": "tr|A0AAA9SB04-1|A0AAA9SB04_BOVIN Isoform 1 of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=1 CANONICAL=A0AAA9SB04-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#A0A3Q1LW11-1", "sequence": { "sequence": "MRKHGIQLYTCECRQETYHSVRGSEGLYMVNGPPHFTESTVFPRESGKNCKAYTFSKDGTLFAWGNGEKINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTASKDDTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQLEKIQKEKALLQELEDLELGI", "length": 596, "header": "tr|A0A3Q1LW11-1|A0A3Q1LW11_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=1 CANONICAL=A0AAA9SB04-1" }, "locus": { "chromosome": "1", "start_pos": 117588446, "end_pos": 117556976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087180.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087180.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061378.1" } ] } }, { "isoform_ac": "A0A3Q1M2B7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#A0A3Q1M2B7-1", "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKAYTFSKDGTLFAWGNGEKINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTASKDDTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKAKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQLEKIQKEKALLQELEDLELGI", "length": 546, "header": "tr|A0A3Q1M2B7-1|A0A3Q1M2B7_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=1 CANONICAL=A0AAA9SB04-1" }, "locus": { "chromosome": "1", "start_pos": 117597936, "end_pos": 117556976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081430.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081430.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064153.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064153.1" } ] } }, { "isoform_ac": "A0AAA9S2G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#A0AAA9S2G9-1", "sequence": { "sequence": "MGFPRESGKNCKAYTFSKDGTLFAWGNGEKINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTASKDDTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQLEKIQKEKALLQELEDLELGI", "length": 557, "header": "tr|A0AAA9S2G9-1|A0AAA9SB04_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=1 CANONICAL=A0AAA9SB04-1" }, "locus": { "chromosome": "1", "start_pos": 117583127, "end_pos": 117556976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133624.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133624.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076303.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076303.1" } ] } }, { "isoform_ac": "A0AAA9SB04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#A0AAA9SB04-1", "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKAYTFSKDGTLFAWGNGEKINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTASKDDTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQVFSAFFIWAHSYYHPSPFYYKQLFNQIKEYIDFKTSFEIRKDRGIRGSW", "length": 613, "header": "tr|A0AAA9SB04-1|A0AAA9SB04_BOVIN Isoform 1 of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=1 CANONICAL=A0AAA9SB04-1" }, "locus": { "chromosome": "1", "start_pos": 117597936, "end_pos": 117560033, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130633.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130633.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083275.1" } ] } }, { "isoform_ac": "A0AAA9T1S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#A0AAA9T1S4-1", "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKAYTFSKDGTLFAWGNGEKINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTDTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQLEKIQKEKALLQELEDLELGI", "length": 524, "header": "tr|A0AAA9T1S4-1|A0AAA9T1S4_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=1 CANONICAL=A0AAA9SB04-1" }, "locus": { "chromosome": "1", "start_pos": 117597936, "end_pos": 117556976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105572.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105572.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090357.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090357.1" } ] } }, { "isoform_ac": "F1MBF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04/entry#F1MBF0-1", "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRINVISVTKKGLLHSFDLPKAVCLEFSPKNTVLATWQPYTASKDDTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDEPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKKYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKAITYQVVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARIDKSPDMPPAPAQQSTPRSTISQSTSGDPETDRKIKNLKKKLRAIEQLKEQAAAGKQLEKNQLEKIQKEKALLQELEDLELGI", "length": 560, "header": "tr|F1MBF0-1|F1MBF0_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 2A OS=Bos taurus OX=9913 GN=EIF2A PE=1 SV=2 CANONICAL=A0AAA9SB04-1" }, "locus": { "chromosome": "1", "start_pos": 117597936, "end_pos": 117556976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012002.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012002.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012002.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012002.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AUH4-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "EIF2A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPSAPLLTVRGSEGLYLVNGPPHFTESTVFPRESGKNCKAYTFSKDGTLFAWGNGERINVINVTTKELLHSFDLPKAVCLEFSPKNTILATWQPYTTSKDGAAGIPNLQLYDMKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLKKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFDGPHAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSVLHKYDVPSNAELWQVSWQPFLDGIFPEKSITYQAVPSDVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPQPGNEKPLSKTALKNQRKHEAKKAAKQEARSDKSPDMAPSPAPQNTPRNTVSHSTSGDPEIDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKEKALLQELEDLELGI", "length": 585 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6GH40-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "Eif2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFSFRDKMAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPREPGKNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNSACFLREPRAMCLKYQEKAPQTCLQSDLIETVPQKVFLDTIANKLHLQKVNDFNLSPGTQPFKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVAWNPSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLYKYDVPSNGELWQVSWQPFLDGIFPAKTITYQAVPSEVPSEEPKVATAYRPPALRNKPVTSSKLHEEEPPQNMKPHPSSDKPLSKTALKNQRKHEAKKAAKQEARNDLAPTPVPQSAPRSTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV", "length": 628 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53235-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSQFFLKTSQDIELFQSYPTFEQSNTNSKDFPVISSVLSPCGRFLALSTKENVKVFTGPCLDNVLLTMKLSDVYDLHFSPAGNYLSTWERASIQDPNHKNVKVWYLNKPFKKDCVSEDIVPAYEYQAKSQSGWFLQFSKLDNYGLRLFKHDLKIVKLSSANADNFDFQSPFAVLSDDETSQHFTTYLISPAEHPTICTFTPEKGGKPAQLIIWALSEGKITKKIASKTFFKADSCQLKWNPLGNAILCLAITDFDSSNKSYYGENTLYLLSFQGVNGTLGGNSVRVSLTTGPVHDFTWSPTSRQFGVIAGYMPATISFFDLRGNVVHSLPQQAKNTMLFSPSGHYILIAGFGNLQGSVEILDRLDKFKCVSKFDATNTSVCKWSPGGEFIMTATTSPRLRVDNGVKIWHVSGSLVFVKEFKELLKVDWRSPCNYKTLENKDEAFFENHIINNWEPLPDSTTSSLDPKISNKSELQIHSSVQEYISQHPSREASSNGNGSKAKAGGAYKPPHARRTGGGRIVPGVPPGAAKKTIPGLVPGMSANKDANTKNRRRRANKKSSETSPDSTPAPSAPASTNAPTNNKETSPEEKKIRSLLKKLRAIETLKERQAVGDKLEDTQVLKIQTEEKVLKDLEKLGWKDE", "length": 642 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5ZKC1-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "EIF2A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPPAPLLAVRGSEGLFMVNGPPSFTESAVFQRDSGRNCKAVAFSKDGSLFAWCNGEKVNIVNVTSAGLLRSFDLPKVVCLEFSPKNNILATWQAYSAAKDGTAGAPNLQLYDVKTGKCLKSFIQKKMQNWCPCWADDESICARNVNNEVHFFENNNFNTIANKLHLQKVNDFVLSPGAQPTKVAVYVPGSKGAPSFVRLYQYPNFGGPQSALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAIVQLPKNGPIYDVVWNPNSVEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHIVTATCAPRLRVSNGYKIWHYTGSVLHNYEVPSNEEMWQVSWQPFLDGVFPVKAVKYQAVPSELPSAEPKPAQAYRPPALRNKPVTSSKLHEDEPPQNMKPQSGSSEKPLSKTALKNQKKHEPKKAAKQEAKADCSQESTQSSASQNTPRSAVPVVTSGDPEIDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKESALLQELEDLELGL", "length": 586 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BJW6-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "Eif2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV", "length": 581 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BY44-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "EIF2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVNIISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGIFPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPLSKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI", "length": 585 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CAT3-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSSPSLEILVREAEGFTVWNGPPFTNGQPTLKLERVSCSNTKFSVDGSKLMAMKSDGVISIYDATSLTEVRSFTIANVTAAELSPCGTYLQTFQKPTTPQEKNVSIWNTETGDLAHSHYQKSITKASWPSIRFCPDESSACRLATNEVQFFDPKDFSKGITSRIRVPGIAAFELSKTPASHVAVFVPESKGSPGSVQIFGCGEELQSQPSARRSFFRCSSVQFSWNHGSTGLLVVVQSDVDKTNQSYYGETKLHYLTIDGTHEGLVPLRKEGPVHDVQWSFSGSEFAVVYGFMPACVTIFDKNCKPLMELGEGPYNTLRWNPKGRVLCVAGFGNLPGDMAFWDVVNKKQLGSNKAEWSVTSEWSPDGRYFLTASTAPRRQIDNGMKIFNYDGKRYYKKMFERLYQAEWKPESPERFGDISELIKSVESLKLGEGKSQGQGSAQKKTIAPNPIAQKPAAYRPPHAKHAAAVQAELLGISTTGEMSKNALKNKKKRENKKAAAAAAAASGSNNA", "length": 513 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VNX8-1", "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "eIF2A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAAADLVVPTLAIRSSVAVELWSSAGSKQPFEHKPHLPREETKSSRSICFSSNGRYFAYSNGQEVKVLQASRDSAASWPVICVLPRPKAFYLQFSPRGSYLCTWEHYAITKDRPEGSPNLLVYEVATGVEVFAIVQKNQADWQPSWSADESIFALVVGGEALFYDLGEGAEKGFATTSRKIGGSRGGMLSLGPGNCPPFLAFYTPGAKGAPSMCKLYKYPALGQNQTVACKSFFQADRVEMLWNKRGSGLLLLTSTEVDKSGASYYGNQAVHFMATKGDTCSVPLSKEGPVHCVKWSPKATEFVVVYGFMPSKAALYNLKCDVVFDFGEGPRNCAYFNPFGNLIALAGFGNLPGAVEVWDVSKREKLANLKCADTTVFEWHPNGEWFVTATTAPRLRISNGFKVYHYSGALLHETMWPQGQELLGIEWQQFADKTFSEPKITKAKHEGIKSSQPEASKKAYTPPHLRLLKEGKNPEKYLPQPSIPGLAPTAAAGGVNGNKRNNKNKQRSARKDVNVVNGGDADSAPTEVVDQAAPVARQSPVFVAAEERKPQHTPRQKYQPDNAADQPPNSYGQGHPNGQHISDKERKIRSVAKKLSDIKKLKVRRSQGENLELNQLNKIKMEAQYLDELKALKQSA", "length": 638 }, "evidence": [ { "id": "A0AAA9SB04", "url": "https://omabrowser.org/oma/group/A0AAA9SB04/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" }, { "name": "ribosome assembly", "id": "GO:0042255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "eukaryotic translation initiation factor 2 complex", "id": "GO:0005850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005850", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB04" }, { "id": "PF08662", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08662" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Translation initiation factor beta propellor-like", "eco_id": "ECO_0000259", "start_pos": 216, "end_pos": 411, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 282, "end_pos": 284 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB92-1", "uniprot_ac": "A0AAA9SB92", "uniprot_id": "A0AAA9SB92_BOVIN", "mass": { "chemical_mass": 60067.0, "monoisotopic_mass": 60067.0 }, "refseq": {}, "gene_names": [ { "name": "TRIM55", "type": "recommended", "evidence": [ { "id": "A0AAA9SB92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ] } ], "protein_names": [ { "name": "RING-type E3 ubiquitin transferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SB92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAA9SB92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92", "locus": { "chromosome": "14", "start_pos": 30516186, "end_pos": 30469091, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021009", "url": "https://www.ensembl.org/id/ENSBTAG00000021009" } ] } } ], "crossref": [ { "id": "A0AAA9SB92", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB92", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021009", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021009", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16760", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16760", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19832", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19832", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CDIHEDE", "url": "https://omabrowser.org/oma/group/CDIHEDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCL8", "url": "https://www.orthodb.org/?gene=E1BCL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S383", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S383", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S383-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S383-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCL8", "url": "https://www.uniprot.org/uniprotkb/E1BCL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCL8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGIYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEDERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLESTCTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKISEASKAFQMEKIEHDYENMNHFTVNLNREEKIIREIDFYREDEDEEEEGEEGEGEGEEEGVEVEEAEDVQTESSGGDQSPEKGLEPSPPTLELQAAPEAPPVPSPDPPPALLPAMEAPVTQGEVVPTGSQQTTESETPVPAATDTAEPLLYPSWYKGQTRKSTANPPSAPGSGSLARVGPSGSKDVHARKAEGAEAAARERAAVSGKDASSPAATSQAGFENPPLQRQAAASGSGNGADSEPARHVFSFSWLNSLSE", "length": 544, "header": "tr|A0AAA9SB92-1|A0AAA9SB92_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM55 PE=4 SV=1 CANONICAL=A0AAA9SB92-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S383-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#A0AAA9S383-1", "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGIYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEDERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLESTCTIEAGFENPPLQRQAAASGSGNGADSEPARHVFSFSWLNSLSE", "length": 240, "header": "tr|A0AAA9S383-1|A0AAA9SB92_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM55 PE=4 SV=1 CANONICAL=A0AAA9SB92-1" }, "locus": { "chromosome": "14", "start_pos": 30515273, "end_pos": 30469248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077730.1" } ] } }, { "isoform_ac": "A0AAA9SB92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#A0AAA9SB92-1", "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGIYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEDERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLESTCTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKISEASKAFQMEKIEHDYENMNHFTVNLNREEKIIREIDFYREDEDEEEEGEEGEGEGEEEGVEVEEAEDVQTESSGGDQSPEKGLEPSPPTLELQAAPEAPPVPSPDPPPALLPAMEAPVTQGEVVPTGSQQTTESETPVPAATDTAEPLLYPSWYKGQTRKSTANPPSAPGSGSLARVGPSGSKDVHARKAEGAEAAARERAAVSGKDASSPAATSQAGFENPPLQRQAAASGSGNGADSEPARHVFSFSWLNSLSE", "length": 544, "header": "tr|A0AAA9SB92-1|A0AAA9SB92_BOVIN Isoform 1 of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM55 PE=4 SV=1 CANONICAL=A0AAA9SB92-1" }, "locus": { "chromosome": "14", "start_pos": 30515273, "end_pos": 30469248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118010.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118010.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081165.1" } ] } }, { "isoform_ac": "A0AAA9TD10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#A0AAA9TD10-1", "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGIYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEDERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLESTCNDEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQSGNLSFCRISEASKAFQMEKIEHDYENMNHFTVNLNREEKIIREIDFYREDEDEEEEGEEGEGEGEEEGVEVEEAEDVQTESSGGDQSPEKGLEPSPPTLELQAAPEAPPVPSPDPPPALLPAMEAPVTQVTQL", "length": 412, "header": "tr|A0AAA9TD10-1|A0AAA9TD10_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM55 PE=4 SV=2 CANONICAL=A0AAA9SB92-1" }, "locus": { "chromosome": "14", "start_pos": 30495865, "end_pos": 30469248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129637.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129637.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095981.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095981.2" } ] } }, { "isoform_ac": "A0AAA9TKV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#A0AAA9TKV0-1", "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGIYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEDERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLESTCTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKISEASKAFQMEKIEHDYENMNHFTVNLNREEKIIREIDFYREDEDEEEEGEEGEGEGEEEGVEVEEAEDVQTESSGGDQSPEKGLEPSPPTLELQAAPEAPPVPSPDPPPALLPAMEAPVTQGEVVPTGSQQTTESETPVPAATDTAEPLLYPSWYKGQTRKSTANPPSAPGSGSLARVGPSGSKDVHARKAEGAEAAARERAAVSGKDASSPAATSQELGICLALLAFLILHYIWRQIQCLIFTLMGWI", "length": 536, "header": "tr|A0AAA9TKV0-1|A0AAA9TKV0_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM55 PE=4 SV=1 CANONICAL=A0AAA9SB92-1" }, "locus": { "chromosome": "14", "start_pos": 30515161, "end_pos": 30469248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091600.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091600.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099074.1" } ] } }, { "isoform_ac": "E1BCL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92/entry#E1BCL8-1", "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGIYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEDERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLESTCTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKISEASKAFQMEKIEHDYENMNHFTVNLNREEKIIREIDFYREDEDEEEEGEEGEGEGEEEGVEVEEAEDVQTESSGGDQSPEKGLEPSPPTLELQAAPEAPPVPSPDPPPALLPAMEAPVTQAGFENPPLQRQAAASGSGNGADSEPARHVFSFSWLNSLSE", "length": 448, "header": "tr|E1BCL8-1|E1BCL8_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=TRIM55 PE=4 SV=3 CANONICAL=A0AAA9SB92-1" }, "locus": { "chromosome": "14", "start_pos": 30515273, "end_pos": 30469248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027975.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027975.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027975.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027975.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3X8Y1-1", "protein_name": "Tripartite motif-containing 55", "gene_name": "Trim55", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHLYGILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKIVEASKAFQMEKLEQGYEIMSNFTVNLNREEKIIREIDFSREEEEEEDAGEIDEEGEGEDAVEVEEAENVQIASSGEEESLEKAAEPSQLPAELQVAPEPLPASSPEPFSSMPPAADVLVTQGEVVPIGSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKTSSNPPCTHGSEGLGQIGPLGIEDSSVQSAEVAEAATNEQAAVSGKESSSTAATSQIGFEAPSPQGQSAALGSGGGADPEPARHVFSFSWLNSLNE", "length": 545 }, "evidence": [ { "id": "A0AAA9SB92", "url": "https://omabrowser.org/oma/group/A0AAA9SB92/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5PQN5-1", "protein_name": "Tripartite motif-containing protein 55", "gene_name": "Trim55", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHLYSILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKITEASKAFQMEKIEQGYEIMNNFTVNLNREEKIIREIDFSREEEDEDDEGEVDEEGEGEDAVEVEEAENVQVASSGEEETLEKAAEPSELAAEIQAASGPLLASSPDSVSSLPPAADVLVTQGEVVPTDSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKMISNPPHTPGGEGLSQIGPSAAEDSSVQSAEVAEAAANEQAAVSGKESSSTAATSQIGFEASSPQGQAAALGSGGGADSEPARHVFSFSWLNSLNE", "length": 545 }, "evidence": [ { "id": "A0AAA9SB92", "url": "https://omabrowser.org/oma/group/A0AAA9SB92/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BYV6-1", "protein_name": "Tripartite motif-containing protein 55", "gene_name": "TRIM55", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQGEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE", "length": 548 }, "evidence": [ { "id": "A0AAA9SB92", "url": "https://omabrowser.org/oma/group/A0AAA9SB92/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" }, { "name": "regulation of microtubule cytoskeleton organization", "id": "GO:0070507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 119, "end_pos": 161, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SB92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" }, { "id": "PS51262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COS", "eco_id": "ECO_0000259", "start_pos": 268, "end_pos": 326, "start_aa": "Met", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SB92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB92" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 82, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 256, "end_pos": 258 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCI8-1", "uniprot_ac": "A0AAA9SCI8", "uniprot_id": "A0AAA9SCI8_BOVIN", "mass": { "chemical_mass": 129118.0, "monoisotopic_mass": 129118.0 }, "refseq": { "ac": "NP_001192386", "name": "zinc finger protein 687", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192386" }, "gene_names": [ { "name": "ZNF687", "type": "recommended", "evidence": [ { "id": "A0AAA9SCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ] }, { "name": "ZNF687", "type": "synonym", "evidence": [ { "id": "NP_001192386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192386" } ] } ], "protein_names": [ { "name": "Zinc finger protein 687", "type": "recommended", "evidence": [ { "id": "A0AAA9SCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 687", "type": "synonym", "evidence": [ { "id": "NP_001192386", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192386" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BQ01", "url": "https://www.uniprot.org/uniprotkb/E1BQ01#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9S5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M5#function" }, { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8#function" }, { "database": "UniProtKB", "id": "A0AAA9TCS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF687", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8", "locus": { "chromosome": "3", "start_pos": 19508959, "end_pos": 19518757, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007318", "url": "https://www.ensembl.org/id/ENSBTAG00000007318" } ] } } ], "crossref": [ { "id": "A0AAA9SCI8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007318", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007318", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "787675", "url": "https://www.ncbi.nlm.nih.gov/gene/787675", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041697", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787675", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787675", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PKVPSCQ", "url": "https://omabrowser.org/oma/group/PKVPSCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BQ01", "url": "https://www.orthodb.org/?gene=E1BQ01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47222:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47222:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9940951", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192386", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ01", "url": "https://www.uniprot.org/uniprotkb/E1BQ01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ01-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGSGKPEPSVGGESGEATAAPAGDGPGGPTQASDHSLPPPDVSAVSVIVKNTVCPEQSESLAGSSGGEGARAGGVTKEGPLGPRLMQNGFGGPEPSLPGTPRSPAPPSGGTWKEKSLEGKAPLDLFAHFGPEPGEHPDPLPPSAPSPPREGALTPPAFPSPFELTRENGPALLPPSSPPLLGTLKQESCSPLHPQSLAQPGSGTSPEATGVPASASPSQVAGVSFFKKSPGHQSPLASPKGPSCQPLKEEEDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTRVPSDPDPPAPLAEGGFLAEANLLKLSPATPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKTMPKNVLGLVPQALPKAEGRTGLGTGGQKVNGASVVMVQPSKPATGPGAAGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLAVPPALGPPALPALGKGEGAVTTSAITAVAAEAPVLPLSTEPPATPATSTYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHLYTQHPSFHTQQAKMIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRPGEETAGKGAGGALLTPKTEPEELAVSRAGTAAPTEESSSTSEEEEPPSSPEPPRPTKRPRRELGSKGMKGGGGGPGGWTCGLCHSWFPERDEYVGHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGAQSPGRGSALARGPGARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGAPGSGGHGPLRYRGGGSAEQSLMVGLRVDGGAQQCLDCGLCFASPGSLSRHRFISHKKKRGVGSASALGLGDGEEEAPPPSRSDPDGGESPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1236, "header": "tr|A0AAA9SCI8-1|A0AAA9SCI8_BOVIN Isoform 1 of Zinc finger protein 687 OS=Bos taurus OX=9913 GN=ZNF687 PE=3 SV=1 CANONICAL=A0AAA9SCI8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8/entry#A0AAA9S5M5-1", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGSGKPEPSVGGESGEATAAPAGDGPGGPTQASDHSLPPPDVSAVSVIVKNTVCPEQSESLAGSSGGEGARAGGVTKEGPLGPRLMQNGFGGPEPSLPGTPRSPAPPSGGTWKEKSLEGKAPLDLFAHFGPEPGEHPDPLPPSAPSPPREGALTPPAFPSPFELTRENGPALLPPSSPPLLGTLKQESCSPLHPQSLAQPGSGTSPEATGVPASASPSQVAGVSFFKKSPGHQSPLASPKGPSCQPLKEEEDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTRVPSDPDPPAPLAEGGFLAEANLLKLSPATPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKTMPKNVLGLVPQALPKAEGRTGLGTGGQKVNGASVVMVQPSKPATGPGAAGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLAVPPALGPPALPALGKGEGAVTTSAITAVAAEAPVLPLSTEPPATPATSTYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHLYTQHPSFHTQQAKMIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRPGEETAGKGAGGALLTPKTEPEELAVSRAGTAAPTEESSSTSEEEEPPSSPEPPRPTKRPRRELGSKGMKGGGGGPGGWTCGLCHSWFPERDEYVGHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGAQSPGRGSALARGPGARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGAPGSGGHGPLRYRGGGSAEQSLMVGLRVDGGAQQCLDCGLCFASPGSLSRHRFISHKKKRGVGSASALGLGDGEEEAPPPSRSDPDGGESPLPASGGPLTCKNT", "length": 1204, "header": "tr|A0AAA9S5M5-1|A0AAA9SCI8_BOVIN Computationally mapped isoform of Zinc finger protein 687 OS=Bos taurus OX=9913 GN=ZNF687 PE=3 SV=1 CANONICAL=A0AAA9SCI8-1" }, "locus": { "chromosome": "3", "start_pos": 19515575, "end_pos": 19509518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110583.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110583.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081222.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081222.1" } ] } }, { "isoform_ac": "A0AAA9SCI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8/entry#A0AAA9SCI8-1", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGSGKPEPSVGGESGEATAAPAGDGPGGPTQASDHSLPPPDVSAVSVIVKNTVCPEQSESLAGSSGGEGARAGGVTKEGPLGPRLMQNGFGGPEPSLPGTPRSPAPPSGGTWKEKSLEGKAPLDLFAHFGPEPGEHPDPLPPSAPSPPREGALTPPAFPSPFELTRENGPALLPPSSPPLLGTLKQESCSPLHPQSLAQPGSGTSPEATGVPASASPSQVAGVSFFKKSPGHQSPLASPKGPSCQPLKEEEDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTRVPSDPDPPAPLAEGGFLAEANLLKLSPATPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKTMPKNVLGLVPQALPKAEGRTGLGTGGQKVNGASVVMVQPSKPATGPGAAGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLAVPPALGPPALPALGKGEGAVTTSAITAVAAEAPVLPLSTEPPATPATSTYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHLYTQHPSFHTQQAKMIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRPGEETAGKGAGGALLTPKTEPEELAVSRAGTAAPTEESSSTSEEEEPPSSPEPPRPTKRPRRELGSKGMKGGGGGPGGWTCGLCHSWFPERDEYVGHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGAQSPGRGSALARGPGARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGAPGSGGHGPLRYRGGGSAEQSLMVGLRVDGGAQQCLDCGLCFASPGSLSRHRFISHKKKRGVGSASALGLGDGEEEAPPPSRSDPDGGESPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1236, "header": "tr|A0AAA9SCI8-1|A0AAA9SCI8_BOVIN Isoform 1 of Zinc finger protein 687 OS=Bos taurus OX=9913 GN=ZNF687 PE=3 SV=1 CANONICAL=A0AAA9SCI8-1" }, "locus": { "chromosome": "3", "start_pos": 19515575, "end_pos": 19510664, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122586.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122586.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083832.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083832.1" } ] } }, { "isoform_ac": "A0AAA9TCS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8/entry#A0AAA9TCS3-1", "sequence": { "sequence": "MEVCPSQCARTSERECLGPIAMGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGSGKPEPSVGGESGEATAAPAGDGPGGPTQASDHSLPPPDVSAVSVIVKNTVCPEQSESLAGSSGGEGARAGGVTKEGPLGPRLMQNGFGGPEPSLPGTPRSPAPPSGGTWKEKSLEGKAPLDLFAHFGPEPGEHPDPLPPSAPSPPREGALTPPAFPSPFELTRENGPALLPPSSPPLLGTLKQESCSPLHPQSLAQPGSGTSPEATGVPASASPSQVAGVSFFKKSPGHQSPLASPKGPSCQPLKEEEDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTRVPSDPDPPAPLAEGGFLAEANLLKLSPATPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKTMPKNVLGLVPQALPKAEGRTGLGTGGQKVNGASVVMVQPSKPATGPGAAGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLAVPPALGPPALPALGKGEGAVTTSAITAVAAEAPVLPLSTEPPATPATSTYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHLYTQHPSFHTQQAKMIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRPGEETAGKGAGGALLTPKTEPEELAVSRAGTAAPTEESSSTSEEEEPPSSPEPPRPTKRPRRELGSKGMKGGGGGPGGWTCGLCHSWFPERDEYVGHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGAQSPGRGSALARGPGARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGAPGSGGHGPLRYRGGGSAEQSLMVGLRVDGGAQQCLDCGLCFASPGSLSRHRFISHKKKRGVGSASALGLGDGEEEAPPPSRSDPDGGESPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1257, "header": "tr|A0AAA9TCS3-1|A0AAA9TCS3_BOVIN Computationally mapped isoform of Zinc finger protein 687 OS=Bos taurus OX=9913 GN=ZNF687 PE=3 SV=1 CANONICAL=A0AAA9SCI8-1" }, "locus": { "chromosome": "3", "start_pos": 19515722, "end_pos": 19510664, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094541.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094541.1" } ] } }, { "isoform_ac": "E1BQ01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8/entry#E1BQ01-1", "sequence": { "sequence": "MHEEYEWIPCCCLGPIAMGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGSGKPEPSVGGESGEATAAPAGDGPGGPTQASDHSLPPPDVSAVSVIVKNTVCPEQSESLAGSSGGEGARAGGVTKEGPLGPRLMQNGFGGPEPSLPGTPRSPAPPSGGTWKEKSLEGKAPLDLFAHFGPEPGEHPDPLPPSAPSPPREGALTPPAFPSPFELTRENGPALLPPSSPPLLGTLKQESCSPLHPQSLAQPGSGTSPEATGVPASASPSQVAGVSFFKKSPGHQSPLASPKGPSCQPLKEEEDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTRVPSDPDPPAPLAEGGFLAEANLLKLSPATPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKTMPKNVLGLVPQALPKAEGRTGLGTGGQKVNGASVVMVQPSKPATGPGAAGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLAVPPALGPPALPALGKGEGAVTTSAITAVAAEAPVLPLSTEPPATPATSTYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHLYTQHPSFHTQQAKMIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRPGEETAGKGAGGALLTPKTEPEELAVSRAGTAAPTEESSSTSEEEEPPSSPEPPRPTKRPRRELGSKGMKGGGGGPGGWTCGLCHSWFPERDEYVGHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGAQSPGRGSALARGPGARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGAPGSGGHGPLRYRGGGSAEQSLMVGLRVDGGAQQCLDCGLCFASPGSLSRHRFISHKKKRGVGSASALGLGDGEEEAPPPSRSDPDGGESPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1253, "header": "tr|E1BQ01-1|A0AAA9SCI8_BOVIN Computationally mapped isoform of Zinc finger protein 687 OS=Bos taurus OX=9913 GN=ZNF687 PE=3 SV=2 CANONICAL=A0AAA9SCI8-1" }, "locus": { "chromosome": "3", "start_pos": 19516056, "end_pos": 19510664, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033811.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033811.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033720.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033720.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 378, "start_aa": "Thr", "end_pos": 378, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr378", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 661, "start_aa": "Thr", "end_pos": 661, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr661", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:787675", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787675", "resource": "KEGG Pathway" }, { "id": "R-BTA-9940951", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "resource": "Reactome", "description": "Interaction of NuRD complexes with transcription factors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1ALB3-1", "protein_name": "Zinc finger protein 687", "gene_name": "ZNF687", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDTNEAIHSGHDEAEAHIKPVPGEPGPPDHVLPHTDITAVSVIVKNTVCPEQLDALDGRSKDGHGLGSRLLQNGFGAAELPRSPAARSVEAVASSNGECWVKEKGPKPLDIFSHFSPDPNEDSAANLIDRARECKPKEKSLAVPSLSPSPTPSLDCKEPGGEGAEGLPPPFPQPFEGSQAGAVSGPPPSVPCIKKEESDSEEAAREANPKALSAALGENPLEHLKSVTVRYSAGDSPITSWPGSDPSLGSGASSLPEVKHSPSSPREPFFKPSSPVVQSPRIPTSPKQLDDITLKEEREALEKSMGSPQSMSSAEEEEEEEEGNTNDSPSSNSSRPLKVRIKTIKTSCGSITRTVTRVSSDSEPGSARGSAEQSSEDAALEAEKEDGVALEVPREKLDLSSPLKAIEGPKIVSVQLGNGTKIKGTVLPVSTIQNASSAMLIAASVAQQKSVVLPAKTGKAVTKNIINLVPQALPKADTRTNASPVTQTTSVTTTANQKLNGTTVVMVQPQKPSPTVAGTVISRSQSSLVEAFNKILNSKNLLPTYKPNLSPPADASLALPPFGYRCLECGDSFALEKSLARHYDRRSMRIEVTCNHCTKRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPIALDQMIGQPDITPLVSVASFPAGKVAGVTQDALSAANGAPELPILPLSSSGSEQSNYSCFRCLECKEQCKDKAGLAAHFQQAVATGTTSSTVCTTCPMIMSNRCSFSAHQRMHKNRPPHVCPECGGNFLLANFETHLKESCLHFSRRVGYRCPSCAVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSAPSAHAHVYTQHPGFGNQQSKMIYKCAMCDTVFTHKPLLSSHFDQHLLNQRVSVFKCPDCPLLFAQKRTMLEHLKNTHQPPKPREEPTKKAAVLLTPKQEPMETPVPKISDESSSSTEEDDPPSSPELRKAKRSRFQRKATSKPKGSGWTCGVCHSWFPERDEYVSHMKKDHGKSVKKFPCHLCERSFCSAPSLRRHVRVNHEGIKRVYPCRFCTEGKRTFSSRLILEKHIQVRHGIKVTDQTKSQEVIIARIGAGAVQVPGRKRKLSSDDGDSCSEEPDSTTPPSKNPKGDRKAPFRCRKCGYVASSAADFQEHIPQHRTDESSHQCRECGLCFTSQVSLNRHRFITHKKKKGAGEAEEPGPRSPLEGAPHAADGALSCTVCGRSFDSQLNLKTHFRTHGMAFIRARQNVSPEN", "length": 1257 }, "evidence": [ { "id": "A0AAA9SCI8", "url": "https://omabrowser.org/oma/group/A0AAA9SCI8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZT56-1", "protein_name": "Zinc finger protein 687", "gene_name": "Zfp687", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGLLANGEYESGQLGLGARRELRERGGRSGEKQEVAAAAGRAAAAAAAVAAGTGGGRRVSARTRIGTSLGPVTMGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGQGKPESSVGGDSKDREAATATENDPESAAEASDHGLPQPPDTSTVSVIVKNTVCPEQSETLTGNSEEETKAGDVTKEGPVGSCLMQNGFGGPEPSLSETPHSSAPASGDAWEEKAGEGKTCLDLFAHFGSEPGDHTDPLPPEPSLPRDGDMAPPPFSTPFELAPENGSTLLPPTSLLPQGALKQESCSPHHSQGLTQRNSGSSPEAAGVPASVSPPQVAGVSFKQSPGHQSPPASPVKAPSCKPLKEEDEGTVDKSPPRSPQSPSSGAEAADEDSNDSPTSSSSSRPLKVRIKTIKTSCGNITRTVTRVPSEPDPPAPLAEGAFLAEASFLKLSPVTPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGNATSPKTMTKNVLGLVPQTLPKAEVRTGFTLGGQKVNGASVVMVQPSKSATGPGTAGGSVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVPGPLALPVLGKGEGAVTSSTITTVATEAPVLPLPTEPPAPPAASVYTCFRCLECKEQCRDKAGMAAHFQQLGPPALGSTSNVCPSCPMMLPNRCSFSAHQRTHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQASHCEVFHKCPICPMAFKSAPSAHAHLYSQHPSFLTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRVGEEAAGKGAGGALLTPKTEPEELAVSQAEAAPATEESSSTSEEELPSSPDPPRPAKRARRELGNKGIKGGGGGPGGWTCGVCHSWCPERDEYVTHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGTQSSGRGGSLVRGSGGRAQGPGRKRRQSSDSCSEEPDSTTPPAKSLRGGPGSGGHGPLRYRSSGSAEQSLVGLRVDGGTQQCLDCGLCFASPGSLSRHRFISHKKRRAGGKASVLGLGDGEEEAPPLRSDPEGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1309 }, "evidence": [ { "id": "A0AAA9SCI8", "url": "https://omabrowser.org/oma/group/A0AAA9SCI8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H2Z9-1", "protein_name": "Zinc finger protein 687", "gene_name": "Znf687", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGQGKPEPSEGGDSGDRAATATTEDDPESPAEASEHGLLQPPDTSTVSVIVKNTVCPEQSETLTENSGEEETKAGGVTKGGPVGSCLMQNGFGGPEPPLSETPHSPAPANGDAWKEKAMEGKTPLDLFAHFGSEPGDHPDPLPPEPSPSQDGDMIPPPFSTPFELAPENGSTLLPPGSLLPEGALKQENCSPPHSQGLTQRSSGSSPEAAGIPASASPPQVAGMSFKQSPGHQSPPASPEKASSCKPLKEEDEGTVDKSPPRSPQSPSSGAEAADEDSNDSPTSSSSARPLKVRIKTIKTSCGNITRTVTRVPSEPDPPAPLPEGAFLAEASFLKLSPVTPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGNVTSPKTMTKSVLGLVPQTLPKAEVRTTLGLGGQKVNGASVVMVQPSKSATGPGTAGGSVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVPGPLALPVLGKGEGAVTSSTITTVATEAPVLPLPTEPPALPTASVYTCFRCLECKEQCRDKAGMAAHFQQLGPPALGSTSNMCPSCPMMLPNRCSFSAHQRTHKNRPPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGINSIKSHIQASHCEVFHKCPICPMAFKSAPSAHAHLYSQHPSFLTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKSTHQSGRLGEEAVGKGAGGALLTPKTEPEELAVSRAEAAPATEESSSSSEEELPSSPEPPRPTKRPRRDLGSKGIKGGGGGPGGWTCGLCHSWFPERDDYVAHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGTQSPSGRGGTLVRGSGGRAQGPGRKRRQSSDSCSEEPDSTTPPAKSLRGGPGSGGHGPLRYRSSGSVEQSIVVGLRVDGGTQQCLDCGLCFASPGSLSRHRFISHKKRRAGGKASALGMADGEEEAPPLRSDPEGGDSPLPVSGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1238 }, "evidence": [ { "id": "A0AAA9SCI8", "url": "https://omabrowser.org/oma/group/A0AAA9SCI8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8N1G0-1", "protein_name": "Zinc finger protein 687", "gene_name": "ZNF687", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGPGKPEPGVGSESEDTAAASAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPGTPHSPAPPSGGTWKEKGMEGKTPLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQSPLASPKVPVCQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTQVPSDPDPPAPLAEGAFLAEASLLKLSPATPTSEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGTATSPKMIAKNVLGLVPQALPKADGRAGLGTGGQKVNGASVVMVQPSKTATGPSTGGGTVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVSGPLALPALGKGEGAITSSAITTVAAEAPVLPLSTEPPAAPATSAYTCFRCLECKEQCRDKAGMAAHFQQLGPPAPGATSNVCPTCPMMLPNRCSFSAHQRMHKNRPPHVCPECGGNFLQANFQTHLREACLHVSRRVGYRCPSCSVVFGGVNSIKSHIQTSHCEVFHKCPICPMAFKSGPSAHAHLYSQHPSFQTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRLEETAGKGAGGALLTPKTEPEELAVSQGGAAPATEESSSSSEEEEVPSSPEPPRPAKRPRRELGSKGLKGGGGGPGGWTCGLCHSWFPERDEYVAHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLQLGAQSPGRGTTLARGSSARAQGPGRKRRQSSDSCSEEPDSTTPPAKSPRGGPGSGGHGPLRYRSSSSTEQSLMMGLRVEDGAQQCLDCGLCFASPGSLSRHRFISHKKRRGVGKASALGLGDGEEEAPPSRSDPDGGDSPLPASGGPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGAVGDN", "length": 1237 }, "evidence": [ { "id": "A0AAA9SCI8", "url": "https://omabrowser.org/oma/group/A0AAA9SCI8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D2D7-1", "protein_name": "Zinc finger protein 687", "gene_name": "Znf687", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDMKTPDFDDLLAAFDIPDIDANEAIHSGPEENEGPGGQGKPEPSVGGDSKDREEAAAAENDPESPAEASDHGLPQPPDTSTVSVIVKNTVCPEQSESLTGDSGEEETKAGGITKEGPVGSCLMQNGFGGPEPSLSENPHSSAHASGNAWKDKAVEGKTCLDLFAHFGSEPGDHPDPLPPEPSQPRGGDMAPPPFSTPFELAPENGSTLLPPASLLPQGALKQESCSPHHSQGLTQRGPGSSPETAGIPASVSPPQVAGVSFKQSPGHQSPPASPVKAPSCKPLKEEDEGTVDKSPPRSPQSPSSGAEAADEDSNDSPTSSSSSRPLKVRIKTIKTSCGNITRTVTRVPSEPDPPAPLAEGAFLAETSFLKLSPVTPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGGNATSPKTMTKSVLGLVPQTLPKAEVRTGFSLGGQKVNGASVVMVQPSKSATGPGTAGGSVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAGLALPPTGYRCLECGDAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVALDQMVGQPDITPLLPVAVPPVPGPLALPVLGKGEGAVTSSTITTVATEAPVLPLPTEPPAPPTASVYTCFRCLECKEQCRDKAGMAAHFQQLGPPALGSTSNVCPSCPMMLPNRCSFSAHQRTHKNRAPHVCPECGGNFLQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQASHCEVFHKCPICPMAFKSAPSAHAHLYSQHPSFLTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHLLPQRVSVFKCPSCPLLFAQKRTMLEHLKNTHQSGRVGEEAVGKGAGGALLTPKTEPEELAVSQAEAAPATEESSSSSEEELPSSPEPPRPTKRARRGELGNKGIKGGGGGPGGWTCGLCHSWCPERDEYVTHMKKEHGKSVKKFPCRLCERSFCSAPSLRRHVRVNHEGIKRVYPCRYCTEGKRTFSSRLILEKHVQVRHGLPLGTQSSGRGGSLARGSGGRAQGPGRKRRQSSDSCSEEPDSTTPPAKSLRGGPGSGGHGPLRYRSSGSAEQSLVGLRVDGGTQQCLDCGLCFASPGSLSRHRFISHKKRRAGGKASVLGLGDGEEAAPPLRSDPEGGDSPLPAPGDPLTCKVCGKSCDSPLNLKTHFRTHGMAFIRARQGGSGDN", "length": 1237 }, "evidence": [ { "id": "A0AAA9SCI8", "url": "https://omabrowser.org/oma/group/A0AAA9SCI8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 532, "end_pos": 550, "start_aa": "Tyr", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 67, 378, 661 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 316, "end_pos": 318 }, { "start_pos": 340, "end_pos": 342 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 516, "end_pos": 518 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA50-1", "uniprot_ac": "A0AAA9SA50", "uniprot_id": "A0AAA9SA50_BOVIN", "mass": { "chemical_mass": 187414.0, "monoisotopic_mass": 187414.0 }, "refseq": {}, "gene_names": [ { "name": "CC2D2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ] } ], "protein_names": [ { "name": "Coiled-coil and C2 domain containing 2A", "type": "synonym", "evidence": [ { "id": "A0AAA9SA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CC2D2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50", "locus": { "chromosome": "6", "start_pos": 110751412, "end_pos": 110620058, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018638", "url": "https://www.ensembl.org/id/ENSBTAG00000018638" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018638", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018638", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517240", "url": "https://www.ncbi.nlm.nih.gov/gene/517240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041510", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041510", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056288", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056288", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8U8", "url": "https://www.orthodb.org/?gene=E1B8U8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZR0", "url": "https://www.orthodb.org/?gene=G3MZR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20837:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20837:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24656", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24656", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U8", "url": "https://www.uniprot.org/uniprotkb/E1B8U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZR0", "url": "https://www.uniprot.org/uniprotkb/G3MZR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZR0-1", "url": "https://www.uniprot.org/uniprotkb/G3MZR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSKEEKVKIISEEFIDDGEDAEEERQKKPLKIPRQKRKKQLPTASREEMVLENSPVDDQQEPVQKGPDTRLLGMTSRRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLQEIPTPRPRRLRSPTEKESETEFGTELDREVQRTQQDHDSQGHSRVKFHDSVRKIKSKPPVPPGFPSAEEAYNFFTFNFDPEPEESEEKPKAKNRHGANREEKEGEEEEPPVQEGVSKTDEEEWLDGKDVEDLLLGLDHTAEDFVAVRPADYQSVHVRLQKEKELLFVPSRRTVPTYKKLPENVQPRYLEDEGLYIGARPEVPRTNQNIMENRLLTQEPGRRWFGDDGRILALPNPIKPVPSRPPMLTQEQDIKAELETLYKKAVKYIHRSQHLIGSGDAPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARRQRNKAKFLTDKLHALRSAVQMGLNPAKTPKTLETTPKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDQKADEEAYEAEIQAEINELLEEHTEEYEQRMEVYRVTLQQWKAWKKAQRAKKKKKKQEAEEHPADEEREEPGPGEEPEKPAPPEPVDRAVIEQQVRERAAQSRRRPGEPTLVPELSLAGSVTPNDQCPRVEVMRREDIKRRSLFLKVTFNNKEVSRTESRPLGADFRVHFGQIFNLQIFNWPESLTLQVYETVGHSGTTLLAEVFLPIPETTVVSGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGGNQLILMTSGKVSNSVAWAIGENGIPLIPPLSQQNIGFRSALKRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPSNGPLMQLISVATSGESYIPDFFRLEQLQQEFNFVSDEELNRSKRFRLLLLRSQEVPEFRHYKQIPLYDREIMEKVFQDYEKRLRDRNVIETKDHIDTHRATVAKYLQQVRESVINRFLIAKHHFLLSDLVVEEEVPNISSEGSGILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPTASKFHQTSRSSRTFTEKHAASPTTHSPAHSADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTGSLQSVKDDVFINIFDEVLYDVLEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERSMMMDRGFDSVRSLSEGSYITLFITLEPQLVPGESVREKMGDMLKKFDSQEDEKLLQATEKFRAECALKFPNRQCLTTVVDVSGKTVFVTRYLKPLNPPQELLDAYPNNPQATAELVARYVSLIPFLPDTVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSMGKKAWLVTGNAIPEGPTAYVLTREQSHYLIWNPCSGHFYGQFDTFCPLKSVSCLIGPDNIWFNIQQYDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQRTDKVAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSMLRHFLPLLERNQEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIEAVYSTGVHNIDAPNVEFALAVYVHPYPRNVLSVWIYVASLIRNR", "length": 1632, "header": "tr|A0AAA9SA50-1|A0AAA9SA50_BOVIN Isoform 1 of Coiled-coil and C2 domain containing 2A OS=Bos taurus OX=9913 GN=CC2D2A PE=4 SV=1 CANONICAL=A0AAA9SA50-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50/entry#A0AAA9S8A0-1", "sequence": { "sequence": "MKSKEEKVKIISEEFIDDGEDAEEERQKKPLKIPRQKRKKQLPTASREEMVLENSPVDDQQEPVQKGPDTRLLGMTSRRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLQEIPTPRPRRLRSPTEKESETEFGTELDREVQRTQQDHDSQGHSRVKFHDSVRKIKSKPPVPPGFPSAEEAYNFFTFNFDPEPEESEEKPKAKNRHGANREEKEGEEEEPPVQEGVSKTDEEEWLDGKDVEDLLLGLDHTAEDFVAVRPADYQSVHVRLQKEKELLFVPSRRTVPTYKKLPENVQPRYLEDEGLYIGARPEVPRTNQNIMENRLLTQEPGRRWFGDDGRILALPNPIKPVPSRPPMLTQEQDIKAELETLYKKAVKYIHRSQHLIGSGDAPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARRQRNKAKFLTDKLHALRSAVQMGLNPAKTPKTLETTPKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDQKADEEAYEAEIQAEINELLEEHTEEYEQRMEVYRVTLQQWKAWKKAQRAKKKKKKQEAEEHPADEEREEPGPGEEPEKPAPPEPVDRAVIEQQVRERAAQSRRRPGEPTLVPELSLAGSVTPNDQCPRVEVMRREDIKRRSLFLKVTFNNKEVSRTESRPLGADFRVHFGQIFNLQIFNWPESLTLQVYETVGHSGTTLLAEVFLPIPETTVVSGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGGNQLILMTSGKVSNSVAWAIGENGIPLIPPLSQQNIGFRSALKRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPSNGPLMQLISVATSGESYIPDFFRLEQLQQEFNFVSDEELNRSKRFRLLLLRSQEVPEFRHYKQIPLYDREIMEKVFQDYEKRLRDRNVIETKDHIDTHRATVAKYLQQVRESVINRFLIAKHHFLLSDLVVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPTASKFHQTSRSSRTFTEKHAASPTTHSPAHSADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTGSLQSVKDDVFINIFDEVLYDVLEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERSMMMDRGFDSVRSLSEGSYITLFITLEPQLVPGESVREKFDSQEDEKLLQATEKFRAECALKFPNRQCLTTVVDVSGKTVFVTRYLKPLNPPQELLDAYPNNPQATAELVARYVSLIPFLPDTVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSMGKKAWLVTGNAIPEGPTAYVLTREQSHYLIWNPCSGHFYGQFDTFCPLKSVSCLIGPDNIWFNIQQYDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQRTDKVAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSMLRHFLPLLERNQEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIEAVYSTGVHNIDAPNVEFALAVYVHPYPRNVLSVWIYVASLIRNR", "length": 1620, "header": "tr|A0AAA9S8A0-1|A0AAA9SA50_BOVIN Computationally mapped isoform of Coiled-coil and C2 domain containing 2A OS=Bos taurus OX=9913 GN=CC2D2A PE=4 SV=1 CANONICAL=A0AAA9SA50-1" }, "locus": { "chromosome": "6", "start_pos": 110751107, "end_pos": 110627975, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123923.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123923.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079564.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079564.1" } ] } }, { "isoform_ac": "A0AAA9SA50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50/entry#A0AAA9SA50-1", "sequence": { "sequence": "MKSKEEKVKIISEEFIDDGEDAEEERQKKPLKIPRQKRKKQLPTASREEMVLENSPVDDQQEPVQKGPDTRLLGMTSRRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLQEIPTPRPRRLRSPTEKESETEFGTELDREVQRTQQDHDSQGHSRVKFHDSVRKIKSKPPVPPGFPSAEEAYNFFTFNFDPEPEESEEKPKAKNRHGANREEKEGEEEEPPVQEGVSKTDEEEWLDGKDVEDLLLGLDHTAEDFVAVRPADYQSVHVRLQKEKELLFVPSRRTVPTYKKLPENVQPRYLEDEGLYIGARPEVPRTNQNIMENRLLTQEPGRRWFGDDGRILALPNPIKPVPSRPPMLTQEQDIKAELETLYKKAVKYIHRSQHLIGSGDAPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARRQRNKAKFLTDKLHALRSAVQMGLNPAKTPKTLETTPKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDQKADEEAYEAEIQAEINELLEEHTEEYEQRMEVYRVTLQQWKAWKKAQRAKKKKKKQEAEEHPADEEREEPGPGEEPEKPAPPEPVDRAVIEQQVRERAAQSRRRPGEPTLVPELSLAGSVTPNDQCPRVEVMRREDIKRRSLFLKVTFNNKEVSRTESRPLGADFRVHFGQIFNLQIFNWPESLTLQVYETVGHSGTTLLAEVFLPIPETTVVSGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGGNQLILMTSGKVSNSVAWAIGENGIPLIPPLSQQNIGFRSALKRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPSNGPLMQLISVATSGESYIPDFFRLEQLQQEFNFVSDEELNRSKRFRLLLLRSQEVPEFRHYKQIPLYDREIMEKVFQDYEKRLRDRNVIETKDHIDTHRATVAKYLQQVRESVINRFLIAKHHFLLSDLVVEEEVPNISSEGSGILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPTASKFHQTSRSSRTFTEKHAASPTTHSPAHSADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTGSLQSVKDDVFINIFDEVLYDVLEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERSMMMDRGFDSVRSLSEGSYITLFITLEPQLVPGESVREKMGDMLKKFDSQEDEKLLQATEKFRAECALKFPNRQCLTTVVDVSGKTVFVTRYLKPLNPPQELLDAYPNNPQATAELVARYVSLIPFLPDTVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSMGKKAWLVTGNAIPEGPTAYVLTREQSHYLIWNPCSGHFYGQFDTFCPLKSVSCLIGPDNIWFNIQQYDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQRTDKVAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSMLRHFLPLLERNQEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIEAVYSTGVHNIDAPNVEFALAVYVHPYPRNVLSVWIYVASLIRNR", "length": 1632, "header": "tr|A0AAA9SA50-1|A0AAA9SA50_BOVIN Isoform 1 of Coiled-coil and C2 domain containing 2A OS=Bos taurus OX=9913 GN=CC2D2A PE=4 SV=1 CANONICAL=A0AAA9SA50-1" }, "locus": { "chromosome": "6", "start_pos": 110751107, "end_pos": 110627975, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112876.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112876.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080303.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080303.1" } ] } }, { "isoform_ac": "A0AAA9TSL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50/entry#A0AAA9TSL2-1", "sequence": { "sequence": "MKSKEEKVKIISEEFIDDGEDAEEERQKKPLKIPRQKRKKQLPTASREEMVLENSPVDDQQEPVQKGPDTRLLGMTSRRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLQEIPTPRPRRLRSPTEKESETEFGTELDREVQRTQQDHDSQGHSRVKFHDSVRKIKSKPPVPPGFPSAEEAYNFFTFNFDPEPEESEEKPKAKNRHGANREEKEGEEEEPPVQEGDEEEWLDGKDVEDLLLGLDHTAEDFVAVRPADYQSVHVRLQKEKELLFVPSRRTVPTYKKLPENVQPRYLEDEGLYIGARPEVPRTNQNIMENRLLTQEPGRRWFGDDGRILALPNPIKPVPSRPPMLTQEQDIKAELETLYKKAVKYIHRSQHLIGSGDAPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARRQRNKAKFLTDKLHALRSAVQMGLNPAKTPKTLETTPKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDQKADEEAYEAEIQAEINELLEEHTEEYEQRMEVYRVTLQQWKAWKKAQRAKKKKKKQEAEEHPADEEREEPGPGEEPEKPAPPEPVDRAVIEQQVRERAAQSRRRPGEPTLVPELSLAGSVTPNDQCPRVEVMRREDIKRRSLFLKVTFNNKEVSRTESRPLGADFRVHFGQIFNLQIFNWPESLTLQVYETVGHSGTTLLAEVFLPIPETTVVSGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGGNQLILMTSGKVSNSVAWAIGENGIPLIPPLSQQNIGFRSALKRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPSNGPLMQLISVATSGESYIPDFFRLEQLQQEFNFVSDEELNRSKRFRLLLLRSQEVPEFRHYKQIPLYDREIMEKVFQDYEKRLRDRNVIETKDHIDTHRATVAKYLQQVRESVINRFLIAKHHFLLSDLVVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPTASKFHQTSRSSRTFTEKHAASPTTHSPAHSADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTGSLQSVKDDVFINIFDEVLYDVLEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARFDSQEDEKLLQATEKFRAECALKFPNRQCLTTVVDVSGKTVFVTRYLKPLNPPQELLDAYPNNPQATAELVARYVSLIPFLPDTVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSMGKKAWLVTGNAIPEGPTAYVLTREQSHYLIWNPCSGHFYGQFDTFCPLKSVSCLIGPDNIWFNIQQYDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQRTDKVAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSMLRHFLPLLERNQEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIEAVYSTGVHNIDAPNVEFALAVYVHPYPRNVLSVWIYVASLIRNR", "length": 1557, "header": "tr|A0AAA9TSL2-1|A0AAA9TSL2_BOVIN Computationally mapped isoform of Coiled-coil and C2 domain containing 2A OS=Bos taurus OX=9913 GN=CC2D2A PE=4 SV=2 CANONICAL=A0AAA9SA50-1" }, "locus": { "chromosome": "6", "start_pos": 110751107, "end_pos": 110627975, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114069.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114069.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101593.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101593.2" } ] } }, { "isoform_ac": "E1B8U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50/entry#E1B8U8-1", "sequence": { "sequence": "MKSKEEKVKIISELPTASREEMVLENSPVDDQQEPVQKGPDTRLLGMTSRRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLQEIPTPRPRRLRSPTEKESETEFGTELDREVQRTQQDHDSQGHSRVKFHDSVRKIKSKPPVPPGFPSAEEAYNFFTFNFDPEPEESEEKPKAKNRHGANREEKEGEEEEPPVQEGDEEEWLDGKDVEDLLLGLDHTAEDFVAVRPADYQSVHVRLQKEKELLFVPSRRTVPTYKKLPENVQPRYLEDEGLYIGARPEVPRTNQNIMENRLLTQEPGRRWFGDDGRILALPNPIKPVPSRPPMLTQEQDIKAELETLYKKAVKYIHRSQHLIGSGDAPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARRQRNKAKFLTDKLHALRSAVQMGLNPAKTPKTLETTPKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDQKADEEAYEAEIQAEINELLEEHTEEYEQRMEVYRVTLQQWKAWKKAQRAKKKKKKQEAEEHPADEEREEPGPGEEPEKPAPPEPVDRAVIEQQVRERAAQSRRRPGEPTLVPELSLAGSVTPNDQCPRVEVMRREDIKRRSLFLKVTFNNKEVSRTESRPLGADFRVHFGQIFNLQIFNWPESLTLQVYETVGHSGTTLLAEVFLPIPETTVVSGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGGNQLILMTSGKVSNSVAWAIGENGIPLIPPLSQQNIGFRSALKRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPSNGPLMQLISVATSGESYIPDFFRLEQLQQEFNFVSDEELNRSKRFRLLLLRSQEVPEFRHYKQIPLYDREIMEKVFQDYEKRLRDRNVIETKDHIDTHRATVAKYLQQVRESVINRFLIAKHHFLLSDLVVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPTASKFHQTSRSSRTFTEKHAASPTTHSPAHSADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTGSLQSVKDDVFINIFDEVLYDVLEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERSMMMDRGFDSVRSLSEGSYITLFITLEPQLVPGESVREKFDSQEDEKLLQATEKFRAECALKFPNRQCLTTVVDVSGKTVFVTRYLKPLNPPQELLDAYPNNPQATAELVARYVSLIPFLPDTVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSMGKKAWLVTGNAIPEGPTAYVLTREQSHYLIWNPCSGHFYGQFDTFCPLKSVSCLIGPDNIWFNIQQYDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQRTDKVAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSMLRHFLPLLERNQEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIEAVYSTGVHNIDAPNVEFALAVYVHPYPRNVLSVWIYVASLIRNR", "length": 1588, "header": "tr|E1B8U8-1|E1B8U8_BOVIN Computationally mapped isoform of Coiled-coil and C2 domain containing 2A OS=Bos taurus OX=9913 GN=CC2D2A PE=4 SV=4 CANONICAL=A0AAA9SA50-1" }, "locus": { "chromosome": "6", "start_pos": 110751107, "end_pos": 110627975, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024802.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024802.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024802.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024802.7" } ] } }, { "isoform_ac": "G3MZR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50/entry#G3MZR0-1", "sequence": { "sequence": "MVLENSPVDDQQEPVQKGPDTRLLGMTSRRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLQEIPTPRPRRLRSPTEKESETEFGTELDREVQRTQQDHDSQGHSRVKFHDSVRKIKSKPPVPPGFPSAEEAYNFFTFNFDPEPEESEEKPKAKNRHGANREEKEGEEEEPPVQEGVSKTDEEEWLDGKDVEDLLLGLDHTAEDFVAVRPADYQSVHVRLQKEKELLFVPSRRTVPTYKKLPENVQPRYLEDEGLYIGARPEVPRTNQNIMENRLLTQEPGRRWFGDDGRILALPNPIKPVPSRPPMLTQEQDIKAELETLYKKAVKYIHRSQHLIGSGDAPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARRQRNKAKFLTDKLHALRSAVQMGLNPAKTPKTLETTPKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDQKADEEAYEAEIQAEINELLEEHTEEYEQRMEVYRVTLQQWKAWKKAQRAKKKKKKQEAEEHPADEEREEPGPGEEPEKPAPPEPVDRAVIEQQVRERAAQSRRRPGEPTLVPELSLAGSVTPNDQCPRVEVMRREDIKRRSLFLKVTFNNKEVSRTESRPLGADFRVHFGQIFNLQIFNWPESLTLQVYETVGHSGTTLLAEVFLPIPETTVVSGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGGNQLILMTSGKVSNSVAWAIGENGIPLIPPLSQQNIGFRSALKRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPSNGPLMQLISVATSGESYIPDFFRLEQLQQEFNFVSDEELNRSKRFRLLLLRSQEVPEFRHYKQIPLYDREIMEKVFQDYEKRLRDRNVIETKDHIDTHRATVAKYLQQVRESVINRFLIAKHHFLLSDLVVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPTASKFHQTSRSSRTFTEKHAASPTTHSPAHSADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTGSLQSVKDDVFINIFDEVLYDVLEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERSMMMDRGFDSVRSLSEGSYITLFITLEPQLVPGESVREKFDSQEDEKLLQATEKFRAECALKFPNRQCLTTVVDVSGKTVFVTRYLKPLNPPQELLDAYPNNPQATAELVARYVSLIPFLPDTVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSMGKKAWLVTGNAIPEGPTAYVLTREQSHYLIWNPCSGHFYGQFDTFCPLKSVSCLIGPDNIWFNIQQYDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQRTDKVAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSMLRHFLPLLERNQEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIEAVYSTGVHNIDAPNVEFALAVYVHPYPRNVLSVWIYVASLIRNR", "length": 1571, "header": "tr|G3MZR0-1|G3MZR0_BOVIN Computationally mapped isoform of Coiled-coil and C2 domain containing 2A OS=Bos taurus OX=9913 GN=CC2D2A PE=4 SV=3 CANONICAL=A0AAA9SA50-1" }, "locus": { "chromosome": "6", "start_pos": 110751107, "end_pos": 110633078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065167.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065167.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055063.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055063.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1409, "start_aa": "Thr", "end_pos": 1409, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1409", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "pmid": "" }, { "name": "protein localization to ciliary transition zone", "id": "GO:1904491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1004, "end_pos": 1006, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1041, "end_pos": 1043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 907, "end_pos": 909, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA50" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 1031, "end_pos": 1209, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1409 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1004, "end_pos": 1006 }, { "start_pos": 1041, "end_pos": 1043 }, { "start_pos": 907, "end_pos": 909 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAC0-1", "uniprot_ac": "A0AAA9SAC0", "uniprot_id": "A0AAA9SAC0_BOVIN", "mass": { "chemical_mass": 68861.0, "monoisotopic_mass": 68861.0 }, "refseq": { "ac": "XP_024841651", "name": "ectonucleoside triphosphate diphosphohydrolase 7 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841651" }, "gene_names": [ { "name": "ENTPD7", "type": "recommended", "evidence": [ { "id": "A0AAA9SAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ] }, { "name": "ENTPD7", "type": "synonym", "evidence": [ { "id": "XP_024841651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841651" } ] } ], "protein_names": [ { "name": "nucleoside-triphosphate phosphatase", "type": "recommended", "evidence": [ { "id": "A0AAA9SAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.15", "type": "synonym", "evidence": [ { "id": "A0AAA9SAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0/entry#names_and_taxonomy" } ] }, { "name": "ectonucleoside triphosphate diphosphohydrolase 7 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024841651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841651" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ENTPD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0", "locus": { "chromosome": "26", "start_pos": 20655969, "end_pos": 20622746, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047077", "url": "https://www.ensembl.org/id/ENSBTAG00000047077" } ] } } ], "crossref": [ { "id": "A0AAA9SAC0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd24045", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd24045", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100300490", "url": "https://www.ncbi.nlm.nih.gov/gene/100300490", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100300490", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300490", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HESIGFM", "url": "https://omabrowser.org/oma/group/HESIGFM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3MYV7", "url": "https://www.orthodb.org/?gene=G3MYV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11782", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11782", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11782:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11782:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01150", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01150", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850843", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024841651", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841651", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SA21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYV7", "url": "https://www.uniprot.org/uniprotkb/G3MYV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYV7-1", "url": "https://www.uniprot.org/uniprotkb/G3MYV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARISFSFLCPASWYFTVPTVSPFSRQRVAFLGLFFISCLLLLMLIMDFRHWGASSPRDRQYERYLARVGDLEATDTEDPDLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVRKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDEADAEAPQELVTGRRRTVGILDMGGASLQIAYEVPTSTSVLSPQEEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGHKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWAACGAMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQEGVRQAHGNWFRLSFVYNHYLFFACILVVLLAIILYLLRLRRIHHRQTRASAPLNLLWIEEVVPMIGVQVGP", "length": 604, "header": "tr|A0AAA9SAC0-1|A0AAA9SAC0_BOVIN Isoform 1 of nucleoside-triphosphate phosphatase OS=Bos taurus OX=9913 GN=ENTPD7 PE=3 SV=1 CANONICAL=A0AAA9SAC0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0/entry#A0AAA9SA21-1", "sequence": { "sequence": "MQRRSELHSFEGGYSSTFQQCPGVIEISFSFLCPASWYFTVPTVSPFSRQRVAFLGLFFISCLLLLMLIMDFRHWGASSPRDRQYERYLARVGDLEATDTEDPDLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVRKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDEADAEAPQELVTGRRRTVGILDMGGASLQIAYEVPTSTSVLSPQEEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGHKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWAACGAMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQEGVRQAHGNWFRLSFVYNHYLFFACILVVLLAIILYLLRLRRIHHRQTRASAPLNLLWIEEVVPMIGVQVGP", "length": 627, "header": "tr|A0AAA9SA21-1|A0AAA9SAC0_BOVIN Computationally mapped isoform of nucleoside-triphosphate phosphatase OS=Bos taurus OX=9913 GN=ENTPD7 PE=3 SV=1 CANONICAL=A0AAA9SAC0-1" }, "locus": { "chromosome": "26", "start_pos": 20654965, "end_pos": 20623504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122894.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122894.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079009.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079009.1" } ] } }, { "isoform_ac": "A0AAA9SAC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0/entry#A0AAA9SAC0-1", "sequence": { "sequence": "MARISFSFLCPASWYFTVPTVSPFSRQRVAFLGLFFISCLLLLMLIMDFRHWGASSPRDRQYERYLARVGDLEATDTEDPDLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVRKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDEADAEAPQELVTGRRRTVGILDMGGASLQIAYEVPTSTSVLSPQEEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGHKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWAACGAMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQEGVRQAHGNWFRLSFVYNHYLFFACILVVLLAIILYLLRLRRIHHRQTRASAPLNLLWIEEVVPMIGVQVGP", "length": 604, "header": "tr|A0AAA9SAC0-1|A0AAA9SAC0_BOVIN Isoform 1 of nucleoside-triphosphate phosphatase OS=Bos taurus OX=9913 GN=ENTPD7 PE=3 SV=1 CANONICAL=A0AAA9SAC0-1" }, "locus": { "chromosome": "26", "start_pos": 20654965, "end_pos": 20623363, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088776.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088776.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079124.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079124.1" } ] } }, { "isoform_ac": "G3MYV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0/entry#G3MYV7-1", "sequence": { "sequence": "MARISFSFLCPASWYFTVPTVSPFSRQRVAFLGLFFISCLLLLMLIMDFRHWGASSPRDRQYERYLARVGDLEATDTEDPDLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVRKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDEADAEAPQELVTGRRRTVGILDMGGASLQIAYEVPTSTSVLSPQEEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGHKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWAACGAMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRCSLFWTISDELLIFGACFFKLNTVTSQGSTAGRCPTGPW", "length": 567, "header": "tr|G3MYV7-1|G3MYV7_BOVIN Computationally mapped isoform of nucleoside-triphosphate phosphatase OS=Bos taurus OX=9913 GN=ENTPD7 PE=3 SV=3 CANONICAL=A0AAA9SAC0-1" }, "locus": { "chromosome": "26", "start_pos": 20654772, "end_pos": 20623363, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000062934.4", "url": "https://www.ensembl.org/id/ENSBTAT00000062934.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054746.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054746.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100300490", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300490", "resource": "KEGG Pathway" }, { "id": "R-BTA-8850843", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850843", "resource": "Reactome", "description": "Phosphate bond hydrolysis by NTPDase proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MB94-1", "protein_name": "nucleoside-triphosphate phosphatase", "gene_name": "Entpd7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFIPCLLLLLLTMDLGHRGTSSPQDRQYERYLARVGDLEATNTEDPNLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVKKHKETPLYILCTAGMRLLPERQQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDESDADTSLDSAVGRRRTVGILDMGGASLQIAYEVPTSTSVLSPKQEEEAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEELVLNETLNKNRLLGQKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGKGDWATCRTVLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLAQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQGGVRQAHGSWFRLSFVYNHYLFFACTLVVLLAIVLYLLRIHRIHRRQTRASAPLDLLWIEQVVPMMGVQVEP", "length": 604 }, "evidence": [ { "id": "A0AAA9SAC0", "url": "https://omabrowser.org/oma/group/A0AAA9SAC0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZNB5-1", "protein_name": "nucleoside-triphosphate phosphatase", "gene_name": "Entpd7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFIPCLLLLLLIMDLRHWTTSLPRDRQYERYLARVGDLEATNTEDPNLSYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVKKHRETPLYILCTAGMRLLPERQQVAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDESDADTSVDSASGRRRTVGILDMGGASLQIAYEVPTSASVLPPKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGQRTGLSPDNPFLDPCLPVGLTDVVERNSQVLHFRGKGDWATCRTMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMTWSVLAQRFKNGLFSSHADEHRLKYQCFKSAWMYEVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQGGVRQAHGSWFRLSFVYNHYLFFACTLVVLLAIVLYLLRIHRIHRRQTRASAPLDLLWIEQVVPMIGVQVGP", "length": 604 }, "evidence": [ { "id": "A0AAA9SAC0", "url": "https://omabrowser.org/oma/group/A0AAA9SAC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S8W2-1", "protein_name": "nucleoside-triphosphate phosphatase", "gene_name": "ENTPD7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARISFSYLCPASWYFTVPTVSPFPRQRVAFLGLFFISCLLLLMLFMDFRHWGTSLPRDRQYERYLARVGDLEATDTEDPNLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHSSDYLRPLLSFAAAHVPVRKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDESDAEAPQELATGRRRTVGILDMGGASLQIAYEVPTSTSVLPPQQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLHKNRLLGQKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWVACRAMLNPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQEGVRQVHGTWFRLSFVYNHYLFFACILVVLLAIILYLLRLRRIHHRQTRASAPLNLLWIEEVVPMIGAEVGP", "length": 604 }, "evidence": [ { "id": "A0AAA9SAC0", "url": "https://omabrowser.org/oma/group/A0AAA9SAC0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P40009-1", "protein_name": "Golgi apyrase", "gene_name": "YND1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQKWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSEYWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKGNWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGNDDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIFHRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMKSSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD", "length": 630 }, "evidence": [ { "id": "A0AAA9SAC0", "url": "https://omabrowser.org/oma/group/A0AAA9SAC0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q3TCT4-1", "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 7", "gene_name": "Entpd7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFIPCVLLLLLIMDLRHWATSLPRDRQYERYLARVGDLEATNTEDPNLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVKKHRETPLYILCTAGMRLLPERQQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDESDSDTSVDSAAGRRRTVGILDMGGASLQIAYEVPTSASDLPPKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGQKTGLSPDNPFLDPCLPVGLTDMVKRNNQVLHFRGKGDWASCRTLLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGHYHGPTFAKAAQDYCGMAWPVLAQRFKNGLFSSHADEHRLKYQCFKSAWMYEVLHEGFHFPYDYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQGQGGVRPAHGSWLRLSFVYNHYLFFACTLVVLLAIVLYLLRIHRIHRRQTRASAPLDLLWIEQVVPMIGVQVGP", "length": 606 }, "evidence": [ { "id": "A0AAA9SAC0", "url": "https://omabrowser.org/oma/group/A0AAA9SAC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQZ7-1", "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 7", "gene_name": "ENTPD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFISCLLLLMLIIDFRHWSASLPRDRQYERYLARVGELEATDTEDPNLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVKKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDESDAEATQELAAGRRRTVGILDMGGASLQIAYEVPTSTSVLPAKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGQKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWVSCGAMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLRTAQLVYDREVQWTLGAILYKTRFLPLRDLRQEGVRQAHGSWFRLSFVYNHYLFFACILVVLLAIFLYLLRLRRIHHRQTRASAPLDLLWLEEVVPMMGVQVGP", "length": 604 }, "evidence": [ { "id": "A0AAA9SAC0", "url": "https://omabrowser.org/oma/group/A0AAA9SAC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "CTPase activity", "id": "GO:0043273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043273", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "ribonucleoside triphosphate phosphatase activity", "id": "GO:0017111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017111", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "GDP phosphatase activity", "id": "GO:0004382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004382", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "UDP phosphatase activity", "id": "GO:0045134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045134", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "nucleobase-containing small molecule catabolic process", "id": "GO:0034656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034656", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "GTP metabolic process", "id": "GO:0046039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "T-helper 17 cell differentiation", "id": "GO:0072539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "CTP catabolic process", "id": "GO:0006254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006254", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "UTP catabolic process", "id": "GO:0046052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "UDP catabolic process", "id": "GO:0006256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006256", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "CTP metabolic process", "id": "GO:0046036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8851494", "name": "NTPDase7 hydrolyzes nucleoside triphosphates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endocytic vesicle lumen, endocytic vesicle membrane", "input_participant_list": [ "R-ALL-8851517" ], "output_participant_list": [ "R-ALL-5228597", "R-ALL-8851513" ], "enzyme_list": [ "A0AAA9SAC0-1" ], "evidence": [ { "id": "R-BTA-8851494", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8851494" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5228597", "participant_name": "H+ [endocytic vesicle lumen]", "crossref": [ { "id": "8145820", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8851513", "participant_name": "Pi [endocytic vesicle lumen]", "crossref": [ { "id": "43474", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8851517", "participant_name": "H2O [endocytic vesicle lumen]", "crossref": [ { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SAC0", "gene_name": "ENTPD7", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "A0AAA9SAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.15", "ec_name": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "3.6.1.15", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 330, "end_pos": 332 }, { "start_pos": 394, "end_pos": 396 }, { "start_pos": 411, "end_pos": 413 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA51-1", "uniprot_ac": "A0AAA9SA51", "uniprot_id": "A0AAA9SA51_BOVIN", "mass": { "chemical_mass": 38296.0, "monoisotopic_mass": 38296.0 }, "refseq": {}, "gene_names": [ { "name": "RPUSD3", "type": "recommended", "evidence": [ { "id": "A0AAA9SA51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ] } ], "protein_names": [ { "name": "RNA pseudouridine synthase D3", "type": "synonym", "evidence": [ { "id": "A0AAA9SA51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPUSD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51", "locus": { "chromosome": "22", "start_pos": 16886849, "end_pos": 16878548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007968", "url": "https://www.ensembl.org/id/ENSBTAG00000007968" } ] } } ], "crossref": [ { "id": "A0AAA9SA51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA51", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007968", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007968", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02869", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02869", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MN91", "url": "https://www.orthodb.org/?gene=F1MN91", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21600", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21600", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21600:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21600:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00849", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00849", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZI0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZI0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN91", "url": "https://www.uniprot.org/uniprotkb/F1MN91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN91-1", "url": "https://www.uniprot.org/uniprotkb/F1MN91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TSAFPSGAKAKLRFLTTRSLAIQIDSQSDQSACCGRSRGSPSGHKHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTVFPSQLQAHMALQLCPVLGDHTYSARVGTVLGQRFLLPVESTKPQRQVLDEALLGRLCLTASQAARLPLHLHLHCLRLPGARPRDPPIELLAPLPSYFSRTLQCLGLHYQ", "length": 355, "header": "tr|A0AAA9SA51-1|A0AAA9SA51_BOVIN Isoform 1 of RNA pseudouridine synthase D3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=4 SV=1 CANONICAL=A0AAA9SA51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51/entry#A0AAA9SA51-1", "sequence": { "sequence": "TSAFPSGAKAKLRFLTTRSLAIQIDSQSDQSACCGRSRGSPSGHKHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTVFPSQLQAHMALQLCPVLGDHTYSARVGTVLGQRFLLPVESTKPQRQVLDEALLGRLCLTASQAARLPLHLHLHCLRLPGARPRDPPIELLAPLPSYFSRTLQCLGLHYQ", "length": 355, "header": "tr|A0AAA9SA51-1|A0AAA9SA51_BOVIN Isoform 1 of RNA pseudouridine synthase D3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=4 SV=1 CANONICAL=A0AAA9SA51-1" }, "locus": { "chromosome": "22", "start_pos": 16886632, "end_pos": 16878747, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089513.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089513.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082198.1" } ] } }, { "isoform_ac": "A0AAA9TYV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51/entry#A0AAA9TYV8-1", "sequence": { "sequence": "MGGWRVLGQASGGWRRGLGIRATSTAAGFGTKARHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTGGSGAPARLE", "length": 244, "header": "tr|A0AAA9TYV8-1|A0AAA9TYV8_BOVIN Computationally mapped isoform of RNA pseudouridine synthase D3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=4 SV=1 CANONICAL=A0AAA9SA51-1" }, "locus": { "chromosome": "22", "start_pos": 16882009, "end_pos": 16878902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118178.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118178.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102696.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102696.1" } ] } }, { "isoform_ac": "A0ABI0NZI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51/entry#A0ABI0NZI0-1", "sequence": { "sequence": "MGGWRVLGQASGGWRRGLGIRATSTAAGFGTKARHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTVFPSQLQAHMALQLCPVLGDHTYSARVGTVLGQRFLLPVESTKPQRQVLDEALLGRLCLTASQAARLPLHLHLHCLRLPGARPRDPPIELLAPLPSYFSRTLQCLGLHYQ", "length": 344, "header": "tr|A0ABI0NZI0-1|A0ABI0NZI0_BOVIN Computationally mapped isoform of RNA pseudouridine synthase D3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=4 SV=1 CANONICAL=A0AAA9SA51-1" }, "locus": { "chromosome": "22", "start_pos": 16886632, "end_pos": 16878902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149916.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149916.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107091.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107091.1" } ] } }, { "isoform_ac": "F1MN91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51/entry#F1MN91-1", "sequence": { "sequence": "MGGWRVLGQASGGWRRGLGIRATSTAAGFGTKARHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDRKGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTVFPSQLQAHMALQLCPVLGDHTYSARVGTVLGQRFLLPVESTKPQRQVLDEALLGRLCLTASQAARLPLHLHLHCLRLPGARPRDPPIELLAPLPSYFSRTLQCLGLHYQ", "length": 329, "header": "tr|F1MN91-1|A0AAA9SA51_BOVIN Computationally mapped isoform of RNA pseudouridine synthase D3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=4 SV=2 CANONICAL=A0AAA9SA51-1" }, "locus": { "chromosome": "22", "start_pos": 16886632, "end_pos": 16878902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010478.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010478.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010478.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010478.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" }, { "name": "pseudouridine synthase activity", "id": "GO:0009982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA pseudouridine synthesis", "id": "GO:1990481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990481", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial translation", "id": "GO:0070131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070131", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" }, { "name": "pseudouridine synthesis", "id": "GO:0001522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001522", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" }, { "name": "enzyme-directed rRNA pseudouridine synthesis", "id": "GO:0000455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000455", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA51" }, { "id": "PF00849", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00849" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pseudouridine synthase RsuA/RluA-like", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 256, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA71-1", "uniprot_ac": "A0AAA9SA71", "uniprot_id": "A0AAA9SA71_BOVIN", "mass": { "chemical_mass": 17489.0, "monoisotopic_mass": 17489.0 }, "refseq": {}, "gene_names": [ { "name": "RAMP3", "type": "recommended", "evidence": [ { "id": "A0AAA9SA71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ] } ], "protein_names": [ { "name": "Receptor activity-modifying protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SA71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAMP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71", "locus": { "chromosome": "4", "start_pos": 76470713, "end_pos": 76493750, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020704", "url": "https://www.ensembl.org/id/ENSBTAG00000020704" } ] } } ], "crossref": [ { "id": "A0AAA9SA71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA71", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14076", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14076", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14076:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14076:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPLFEFPETHSKFPLAIYFTYGESPPVGGCNEKRMLAMLPRCGKTFAEKMKKVEVWKWCNLSEFIVYYESFTNCTEVETNVVGCYWPNPLAESFIASVHRQFFQNCSVDRQDWEDPPDEILIPLITVPVLLTIAMTGVVVWRSKHTEQVL", "length": 151, "header": "tr|A0AAA9SA71-1|A0AAA9SA71_BOVIN Isoform 1 of Receptor activity-modifying protein 3 OS=Bos taurus OX=9913 GN=RAMP3 PE=3 SV=2 CANONICAL=A0AAA9SA71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71/entry#A0AAA9SA71-1", "sequence": { "sequence": "MEPLFEFPETHSKFPLAIYFTYGESPPVGGCNEKRMLAMLPRCGKTFAEKMKKVEVWKWCNLSEFIVYYESFTNCTEVETNVVGCYWPNPLAESFIASVHRQFFQNCSVDRQDWEDPPDEILIPLITVPVLLTIAMTGVVVWRSKHTEQVL", "length": 151, "header": "tr|A0AAA9SA71-1|A0AAA9SA71_BOVIN Isoform 1 of Receptor activity-modifying protein 3 OS=Bos taurus OX=9913 GN=RAMP3 PE=3 SV=2 CANONICAL=A0AAA9SA71-1" }, "locus": { "chromosome": "4", "start_pos": 76485665, "end_pos": 76471666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092736.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092736.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080324.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080324.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "receptor internalization", "id": "GO:0031623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031623", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "response to amyloid-beta", "id": "GO:1904645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904645", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of calcium-mediated signaling", "id": "GO:0050850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050850", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of protein localization to plasma membrane", "id": "GO:1903078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of receptor recycling", "id": "GO:0001921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001921", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "cellular response to estradiol stimulus", "id": "GO:0071392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071392", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "adrenomedullin receptor signaling pathway", "id": "GO:1990410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "regulation of G protein-coupled receptor signaling pathway", "id": "GO:0008277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway involved in heart process", "id": "GO:0086103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086103", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "positive regulation of cAMP/PKA signal transduction", "id": "GO:0141163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141163", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "amylin receptor 3 signaling pathway", "id": "GO:0150061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150061", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "amylin receptor complex 3", "id": "GO:0150058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150058", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "adrenomedullin receptor complex", "id": "GO:1903143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903143", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "adrenomedullin receptor activity", "id": "GO:0001605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "amylin receptor activity", "id": "GO:0097643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097643", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" }, { "name": "signaling receptor regulator activity", "id": "GO:0030545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030545", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 61, "end_pos": 63 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA75-1", "uniprot_ac": "A0AAA9SA75", "uniprot_id": "A0AAA9SA75_BOVIN", "mass": { "chemical_mass": 193991.0, "monoisotopic_mass": 193991.0 }, "refseq": { "ac": "XP_059739009", "name": "synaptotagmin-like protein 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739009" }, "gene_names": [ { "name": "SYTL2", "type": "recommended", "evidence": [ { "id": "A0AAA9SA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ] }, { "name": "SYTL2", "type": "synonym", "evidence": [ { "id": "XP_059739009", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739009" } ] } ], "protein_names": [ { "name": "Synaptotagmin-like protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75/entry#names_and_taxonomy" } ] }, { "name": "synaptotagmin-like protein 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059739009", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739009" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYTL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75", "locus": { "chromosome": "29", "start_pos": 9862424, "end_pos": 9741771, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000460", "url": "https://www.ensembl.org/id/ENSBTAG00000000460" } ] } } ], "crossref": [ { "id": "ENSBTAG00000000460", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000460", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04020", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04020", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08393", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08393", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614406", "url": "https://www.ncbi.nlm.nih.gov/gene/614406", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MY23", "url": "https://www.orthodb.org/?gene=F1MY23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739009", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739009", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY23", "url": "https://www.uniprot.org/uniprotkb/F1MY23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY23-1", "url": "https://www.uniprot.org/uniprotkb/F1MY23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKVKDDQQLKNMSGQWFYEAKAKRHRDRIHGADIIRASMRKKRPQVADEQSKDRANRAKESWVNNVHKDAFLPPELTGVVEEPEEDVAPASPSSSVVNPASTMIDASQENTRKSAISPAKPRKNPFNSSMLPEDHLSQQTKNEQSKNGKTGLFQTSKEGELSESKEESSILDISSQKLEKPKQTLPGPESGFPIKAPVPKPRKMIYKSQDLKQDDNQPFPRQRTDSLTTRGAPRGILKRNSSSSSTDSETVRFHQNFEPKSKIVSLGLTIHERISEKEHSLEDDSPSNSLEPLKHVRFSAVKDELPQSSGLVHGREVGEFSVLESDRLKNGTEDAGLTDEVWNDPQPSQYTNGLPFQSSASSPSPSKNETSQPTTSGSFPINEHPSSKEFLTTRAQSTENSHTINEHKTSSSELSKNPADELSCTEPELSQVPDCSSRDHQQGKPPLLQALRAKTSSHSGPYATEIRKTTDDSISKVLDWFNRSSYSDDSVASLQYPQDIEPKEKPDSKPQIAVALVTEDASQEGNGLIALLPTKVELTPVGPDSTFQVEEHTLPSGNCQDNNVHIKPRSINLFPQGKESLGMLQPFEIYSPNQESKTKDYSQGSKNIGKAVGVLIPANKCSYSVHKGPHAEDQVLCNIKDAGSLGEEEPQLRVYEKNIRKSEVNFDSSTIIQEPSLKAHAKAESESKGRDTSILKSSLEPENIESPPGAASGVSPWKKLEVQVPEAGEVPQNRVQREKYKRVSDRISFWESTKAAIHKEPPPPFSQERPSAKARQPVMSMDSLPMSRGKCNTQVTTKQVILDNDGQAAHVSGFYSSKKPKETRPQISGPSKNDPSADQSGTVSLFQNKTTEPVKRLPVTDSLHSEKDITFPPLHHPSNVGIEMHTSLEKDRSLIGERNPNFKVMSLQERINEPNTEQVYNHSQFENLRRFWDLGANPNCQDNIEKNTTTISQKNSVLFNSQKHKEFSDVTSSGNSTHEREMLLDQKEIPAREEIEKLNSKGTLQVLPDDTTFPWRPPRKSTHQLPRYESSKENMGKNTECFVTPMFKGENDDSDQELEEIQESIVKTSVSSKDYKDTLNDSLQKLLFEASSPVLQPSGGNVQEKQVFEPDVSENRTWPQETDFAAPEEEAKRPKEISNEHIDKTVAPPKAYLNTLTASLDKLLKEATGSPPSPLQTKCEPTTTGISSESEESSVDENRIEQSQNTSADEREKMASFPEGTETWGNSSLSQEAQSGSEEEPSPVLKILERSAARKMPSKSLEDISSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVSSQPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASEGSYQLSRHKKSPSSLTNLSSNSGMTSLSSVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK", "length": 1736, "header": "tr|A0AAA9SA75-1|A0AAA9SA75_BOVIN Isoform 1 of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=4 SV=1 CANONICAL=A0AAA9SA75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75/entry#A0AAA9SA75-1", "sequence": { "sequence": "MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKVKDDQQLKNMSGQWFYEAKAKRHRDRIHGADIIRASMRKKRPQVADEQSKDRANRAKESWVNNVHKDAFLPPELTGVVEEPEEDVAPASPSSSVVNPASTMIDASQENTRKSAISPAKPRKNPFNSSMLPEDHLSQQTKNEQSKNGKTGLFQTSKEGELSESKEESSILDISSQKLEKPKQTLPGPESGFPIKAPVPKPRKMIYKSQDLKQDDNQPFPRQRTDSLTTRGAPRGILKRNSSSSSTDSETVRFHQNFEPKSKIVSLGLTIHERISEKEHSLEDDSPSNSLEPLKHVRFSAVKDELPQSSGLVHGREVGEFSVLESDRLKNGTEDAGLTDEVWNDPQPSQYTNGLPFQSSASSPSPSKNETSQPTTSGSFPINEHPSSKEFLTTRAQSTENSHTINEHKTSSSELSKNPADELSCTEPELSQVPDCSSRDHQQGKPPLLQALRAKTSSHSGPYATEIRKTTDDSISKVLDWFNRSSYSDDSVASLQYPQDIEPKEKPDSKPQIAVALVTEDASQEGNGLIALLPTKVELTPVGPDSTFQVEEHTLPSGNCQDNNVHIKPRSINLFPQGKESLGMLQPFEIYSPNQESKTKDYSQGSKNIGKAVGVLIPANKCSYSVHKGPHAEDQVLCNIKDAGSLGEEEPQLRVYEKNIRKSEVNFDSSTIIQEPSLKAHAKAESESKGRDTSILKSSLEPENIESPPGAASGVSPWKKLEVQVPEAGEVPQNRVQREKYKRVSDRISFWESTKAAIHKEPPPPFSQERPSAKARQPVMSMDSLPMSRGKCNTQVTTKQVILDNDGQAAHVSGFYSSKKPKETRPQISGPSKNDPSADQSGTVSLFQNKTTEPVKRLPVTDSLHSEKDITFPPLHHPSNVGIEMHTSLEKDRSLIGERNPNFKVMSLQERINEPNTEQVYNHSQFENLRRFWDLGANPNCQDNIEKNTTTISQKNSVLFNSQKHKEFSDVTSSGNSTHEREMLLDQKEIPAREEIEKLNSKGTLQVLPDDTTFPWRPPRKSTHQLPRYESSKENMGKNTECFVTPMFKGENDDSDQELEEIQESIVKTSVSSKDYKDTLNDSLQKLLFEASSPVLQPSGGNVQEKQVFEPDVSENRTWPQETDFAAPEEEAKRPKEISNEHIDKTVAPPKAYLNTLTASLDKLLKEATGSPPSPLQTKCEPTTTGISSESEESSVDENRIEQSQNTSADEREKMASFPEGTETWGNSSLSQEAQSGSEEEPSPVLKILERSAARKMPSKSLEDISSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVSSQPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASEGSYQLSRHKKSPSSLTNLSSNSGMTSLSSVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK", "length": 1736, "header": "tr|A0AAA9SA75-1|A0AAA9SA75_BOVIN Isoform 1 of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=4 SV=1 CANONICAL=A0AAA9SA75-1" }, "locus": { "chromosome": "29", "start_pos": 9861497, "end_pos": 9796272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092588.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092588.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080818.1" } ] } }, { "isoform_ac": "A0AAA9SJB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75/entry#A0AAA9SJB3-1", "sequence": { "sequence": "MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKVKDDQQLKNMSGQWFYEAKAKRHRDRIHGADIIRASMRKKRPQVADEQSKDRANRAKESWVNNVHKDAFLPPELTGVVEEPEEDVAPASPSSSVVNPASTMIDASQENTRKSAISPAKPRKNPFNSSMLPEDHLSQQTKNEQSKNGKTGLFQTSKEGELSESKEESSILDISSQKLEKPKQTLPGPESGFPIKAPVPKPRKMIYKSQDLKQDDNQPFPRQRTDSLTTRGAPRGILKRNSSSSSTDSETVRFHQNFEPKSKIVSLGLTIHERISEKEHSLEDDSPSNSLEPLKHVRFSAVKDELPQSSGLVHGREVGEFSVLESDRLKNGTEDAGLTDEVWNDPQPSQYTNGLPFQSSASSPSPSKNETSQPTTSGSFPINEHPSSKEFLTTRAQSTENSHTINEHKTSSSELSKNPADELSCTEPELSQVPDCSSRDHQQGSEEEPSPVLKILERSAARKMPSKSLEDISSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVSSQPDNQFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK", "length": 903, "header": "tr|A0AAA9SJB3-1|A0AAA9SJB3_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=4 SV=1 CANONICAL=A0AAA9SA75-1" }, "locus": { "chromosome": "29", "start_pos": 9861497, "end_pos": 9796272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124412.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124412.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082676.1" } ] } }, { "isoform_ac": "A0AAA9SUT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75/entry#A0AAA9SUT7-1", "sequence": { "sequence": "MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKVKDDQQLKNMSGQWFYEAKAKRHRDRIHGADIIRASMRKKRPQVADEQSKDRANRAKESWVNNVHKDAFLPPELTGVVEEPEEDVAPASPSSSVVNPASTMIDASQENTRKSAISPAKPRKNPFNSSMLPEDHLSQQTKNEQSKNGKTGLFQTSKEGELSESKEESSILDISSQKLEKPKQTLPGPESGFPIKAPVPKPRKMIYKSQDLKQDDNQPFPRQRTDSLTTRGAPRGILKRNSSSSSTDSETVRFHQNFEPKSKIVSLGLTIHERISEKEHSLEDDSPSNSLEPLKHVRFSAVKDELPQSSGLVHGREVGEFSVLESDRLKNGTEDAGLTDEVWNDPQPSQYTNGLPFQSSASSPSPSKNETSQPTTSGSFPINEHPSSKEFLTTRAQSTENSHTINEHKTSSSELSKNPADELSCTEPELSQVPDCSSRDHQQGKPPLLQALRAKTSSHSGPYATEIRKTTDDSISKVLDWFNRSSYSDDSVASLQYPQDIEPKEKPDSKPQIAVALVTEDASQEGNGLIALLPTKVELTPVGPDSTFQVEEHTLPSGNCQDNNVHIKPRSINLFPQGKESLGMLQPFEIYSPNQESKTKDYSQGSKNIGKAVGVLIPANKCSYSVHKGPHAEDQVLCNIKDAGSLGEEEPQLRVYEKNIRKSEVNFDSSTIIQEPSLKAHAKAESESKGRDTSILKSSLEPENIESPPGAASGVSPWKKLEVQVPEAGEVPQNRVQREKYKRVSDRISFWESTKAAIHKEPPPPFSQERPSAKARQPVMSMDSLPMSRGKCNTQVTTKQVILDNDGQAAHVSGFYSSKKPKETRPQISGPSKNDPSADQSGTVSLFQNKTTEPVKRLPVTDSLHSEKDITFPPLHHPSNVGIEMHTSLEKDRSLIGERNPNFKVMSLQERINEPNTEQVYNHSQFENLRRFWDLGANPNCQDNIEKNTTTISQKNSVLFNSQKHKEFSDVTSSGNSTHEREMLLDQKEIPAREEIEKLNSKGTLQVLPDDTTFPWRPPRKSTHQLPRYESSKENMGKNTECFVTPMFKGENDDSDQELEEIQESIVKTSVSSKDYKDTLNDSLQKLLFEASSPVLQPSGGNVQEKQVFEPDVSENRTWPQETDFAAPEEEAKRPKEISNEHIDKTVAPPKAYLNTLTASLDKLLKEATGSPPSPLQTKCEPTTTGISSESEESSVDENRIEQSQNTSADEREKMASFPEGTETWGNSSLSQEAQSGSEEEPSPVLKILERSAARKMPSKSLEDISSDSSNQAKVDNLPEELVRSAEDVSTVSSQPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASEGSYQLSRHKKSPSSLTNLSSNSGMTSLSSVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK", "length": 1720, "header": "tr|A0AAA9SUT7-1|A0AAA9SUT7_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=4 SV=1 CANONICAL=A0AAA9SA75-1" }, "locus": { "chromosome": "29", "start_pos": 9861497, "end_pos": 9796272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116694.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116694.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086931.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086931.1" } ] } }, { "isoform_ac": "A0AAA9T1I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75/entry#A0AAA9T1I8-1", "sequence": { "sequence": "MSDDRETDTASEGSYQLSRHKKSPSSLTNLSSNSGMTSLSSVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK", "length": 365, "header": "tr|A0AAA9T1I8-1|A0AAA9T1I8_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=4 SV=1 CANONICAL=A0AAA9SA75-1" }, "locus": { "chromosome": "29", "start_pos": 9861497, "end_pos": 9840705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119765.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119765.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090265.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090265.1" } ] } }, { "isoform_ac": "F1MY23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75/entry#F1MY23-1", "sequence": { "sequence": "MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKVKDDQQLKNMSGQWFYEAKAKRHRDRIHGADIIRASMRKKRPQVADEQSKDRANRAKESWVNNVHKDAFLPPELTGVVEEPEEDVAPASPSSSVVNPASTMIDASQENTRKSAISPAKPRKNPFNSSMLPEDHLSQQTKNEQSKNGKTGLFQTSKEGELSESKEESSILDISSQKLEKPKQTLPGPESGFPIKAPVPKPRKMIYKSQDLKQDDNQPFPRQRTDSLTTRGAPRGILKRNSSSSSTDSETVRFHQNFEPKSKIVSLGLTIHERISEKEHSLEDDSPSNSLEPLKHVRFSAVKDELPQSSGLVHGREVGEFSVLESDRLKNGTEDAGLTDEVWNDPQPSQYTNGLPFQSSASSPSPSKNETSQPTTSGSFPINEHPSSKEFLTTRAQSTENSHTINEHKTSSSELSKNPAGSEEEPSPVLKILERSAARKMPSKSLEDISSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVSSQPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASEGSYQLSRHKKSPSSLTNLSSNSGMTSLSSVSGSVMSVYSGDFGNLEVKGSIQFAIDYVDSLKELHVFVAQCKDLAAADIKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKINKQILKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLKWYPLKRKTAPVPLEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLTEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVKSPNTWIEAILPLRMLLIAKISK", "length": 920, "header": "tr|F1MY23-1|A0AAA9SA75_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=4 SV=4 CANONICAL=A0AAA9SA75-1" }, "locus": { "chromosome": "29", "start_pos": 9861497, "end_pos": 9796272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030378.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030378.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030362.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030362.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1012, "end_pos": 1014, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1117, "end_pos": 1119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1152, "end_pos": 1154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1242, "end_pos": 1244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1263, "end_pos": 1265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1517, "end_pos": 1519, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1646, "end_pos": 1648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 519, "end_pos": 521, "annotation": "n_glycosylation_sequon" }, { "start_pos": 885, "end_pos": 887, "annotation": "n_glycosylation_sequon" }, { "start_pos": 958, "end_pos": 960, "annotation": "n_glycosylation_sequon" }, { "start_pos": 984, "end_pos": 986, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 1430, "end_pos": 1555, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA75" }, { "id": "PS50916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RabBD", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 57, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1012, "end_pos": 1014 }, { "start_pos": 1117, "end_pos": 1119 }, { "start_pos": 1152, "end_pos": 1154 }, { "start_pos": 1242, "end_pos": 1244 }, { "start_pos": 1263, "end_pos": 1265 }, { "start_pos": 1400, "end_pos": 1402 }, { "start_pos": 1517, "end_pos": 1519 }, { "start_pos": 1646, "end_pos": 1648 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 367, "end_pos": 369 }, { "start_pos": 405, "end_pos": 407 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 519, "end_pos": 521 }, { "start_pos": 885, "end_pos": 887 }, { "start_pos": 958, "end_pos": 960 }, { "start_pos": 984, "end_pos": 986 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA89-1", "uniprot_ac": "A0AAA9SA89", "uniprot_id": "A0AAA9SA89_BOVIN", "mass": { "chemical_mass": 33375.0, "monoisotopic_mass": 33375.0 }, "refseq": {}, "gene_names": [ { "name": "YAE1", "type": "recommended", "evidence": [ { "id": "A0AAA9SA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89" } ] } ], "protein_names": [ { "name": "YAE1 maturation factor of ABCE1", "type": "synonym", "evidence": [ { "id": "A0AAA9SA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YAE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89", "locus": { "chromosome": "4", "start_pos": 81269839, "end_pos": 81291765, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064967", "url": "https://www.ensembl.org/id/ENSBTAG00000064967" } ] } } ], "crossref": [ { "id": "A0AAA9SA89", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA89", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR18829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18829:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18829:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTSKYQGTKASGGNQDLPGTRDHPVNPSRRSDTVHIYAHAQQCREPGCLSSSRPSDRKELPTLPASGGPVVASVMSWVQAASLVQGPEEERDVFDEEADESLLVQREWRSHMQRRVKEGYRDGIDAGKAVTLQQGFNQGYKEGAEVIINYGQLRGTLSALLSWCHLHDNSSALISKINNLLDAVGQCEEYVLRHLKSITSQPHVVDLLDSLQDMDLCHVAPAEEKIDEVKDERFCENNAEFNKNCSKNLSQVDCSSLKCCRAQEHACPENPSLTWILEQTASLVKQLGVSVDILQHLKQL", "length": 301, "header": "tr|A0AAA9SA89-1|A0AAA9SA89_BOVIN Isoform 1 of YAE1 maturation factor of ABCE1 OS=Bos taurus OX=9913 GN=YAE1 PE=4 SV=1 CANONICAL=A0AAA9SA89-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89/entry#A0AAA9SA89-1", "sequence": { "sequence": "MGTSKYQGTKASGGNQDLPGTRDHPVNPSRRSDTVHIYAHAQQCREPGCLSSSRPSDRKELPTLPASGGPVVASVMSWVQAASLVQGPEEERDVFDEEADESLLVQREWRSHMQRRVKEGYRDGIDAGKAVTLQQGFNQGYKEGAEVIINYGQLRGTLSALLSWCHLHDNSSALISKINNLLDAVGQCEEYVLRHLKSITSQPHVVDLLDSLQDMDLCHVAPAEEKIDEVKDERFCENNAEFNKNCSKNLSQVDCSSLKCCRAQEHACPENPSLTWILEQTASLVKQLGVSVDILQHLKQL", "length": 301, "header": "tr|A0AAA9SA89-1|A0AAA9SA89_BOVIN Isoform 1 of YAE1 maturation factor of ABCE1 OS=Bos taurus OX=9913 GN=YAE1 PE=4 SV=1 CANONICAL=A0AAA9SA89-1" }, "locus": { "chromosome": "4", "start_pos": 81291566, "end_pos": 81287367, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097443.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097443.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082994.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082994.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA89" }, { "id": "PF09811", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09811" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Essential protein Yae1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 158, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 245, "end_pos": 247 }, { "start_pos": 249, "end_pos": 251 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA91-1", "uniprot_ac": "A0AAA9SA91", "uniprot_id": "A0AAA9SA91_BOVIN", "mass": { "chemical_mass": 11676.0, "monoisotopic_mass": 11676.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SA91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91", "locus": {} } ], "crossref": [ { "id": "A0AAA9SA91", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA91", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GNKVEQSPTLSVQEGNSSVITCTYTDGNSAYFPWYKQEPGKGPQFLIAIRSNKGKEEDQRLTVLLNKTTKRLSLHITTTEAGDSAVYFCAASTQCFPGIFCLYSNL", "length": 106, "header": "tr|A0AAA9SA91-1|A0AAA9SA91_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SA91-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91/entry#A0AAA9SA91-1", "sequence": { "sequence": "GNKVEQSPTLSVQEGNSSVITCTYTDGNSAYFPWYKQEPGKGPQFLIAIRSNKGKEEDQRLTVLLNKTTKRLSLHITTTEAGDSAVYFCAASTQCFPGIFCLYSNL", "length": 106, "header": "tr|A0AAA9SA91-1|A0AAA9SA91_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SA91-1" }, "locus": { "chromosome": "10", "start_pos": 25098573, "end_pos": 25098256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117595.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117595.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080833.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080833.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA91" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 92, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SA92-1", "uniprot_ac": "A0AAA9SA92", "uniprot_id": "A0AAA9SA92_BOVIN", "mass": { "chemical_mass": 49757.0, "monoisotopic_mass": 49757.0 }, "refseq": {}, "gene_names": [ { "name": "HHLA2", "type": "recommended", "evidence": [ { "id": "A0AAA9SA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" } ] } ], "protein_names": [ { "name": "HHLA2 member of B7 family", "type": "synonym", "evidence": [ { "id": "A0AAA9SA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HHLA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92", "locus": { "chromosome": "1", "start_pos": 53120214, "end_pos": 52988393, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018397", "url": "https://www.ensembl.org/id/ENSBTAG00000018397" } ] } } ], "crossref": [ { "id": "A0AAA9SA92", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SA92", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00099", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00099", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101908484", "url": "https://www.ncbi.nlm.nih.gov/gene/101908484", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101908484", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101908484", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR25466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25466:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25466:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAQAVLAFFFTLIPSLCGPQDASFSHVSMNEQIVTGRLGEDVILPCSFESGPNVVIHWKNQDTNVYSYYRDSDQLEKQDPRYVNRISLFHGEIHNGNASLSFRRLTLQDEGIYVCYVGTSLGKITKKIVLKVGAFVTPVMKYEKNTTNSFLICNVLSVFPYPIITWKVDNNTSISENNGKEVGSLGPFHINSRVNITGSNSSYQCEIENPLLKQTWTGRWTRKDVLHKMQSENVLLSCKPENSFFPPNQDFTVTWYRVESGSALLLAYFKNSSQETLINQPRLSWKEELINSRDFSLTVKDLHLSDSGEYLCDISSNESTLLTSQTLHVEASPRAPAGIIVPVLVAVVSAVLLLSVAPRAVRSKRCIGFHRERHPPTNQDSSSAGTTEENVVLLLLLLLSRFSCVRLCATPQTAAHQAPPSLGFSRQEHWSGLPFPSPMHESEK", "length": 445, "header": "tr|A0AAA9SA92-1|A0AAA9SA92_BOVIN Isoform 1 of HHLA2 member of B7 family OS=Bos taurus OX=9913 GN=HHLA2 PE=4 SV=1 CANONICAL=A0AAA9SA92-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92/entry#A0AAA9SA92-1", "sequence": { "sequence": "MKAQAVLAFFFTLIPSLCGPQDASFSHVSMNEQIVTGRLGEDVILPCSFESGPNVVIHWKNQDTNVYSYYRDSDQLEKQDPRYVNRISLFHGEIHNGNASLSFRRLTLQDEGIYVCYVGTSLGKITKKIVLKVGAFVTPVMKYEKNTTNSFLICNVLSVFPYPIITWKVDNNTSISENNGKEVGSLGPFHINSRVNITGSNSSYQCEIENPLLKQTWTGRWTRKDVLHKMQSENVLLSCKPENSFFPPNQDFTVTWYRVESGSALLLAYFKNSSQETLINQPRLSWKEELINSRDFSLTVKDLHLSDSGEYLCDISSNESTLLTSQTLHVEASPRAPAGIIVPVLVAVVSAVLLLSVAPRAVRSKRCIGFHRERHPPTNQDSSSAGTTEENVVLLLLLLLSRFSCVRLCATPQTAAHQAPPSLGFSRQEHWSGLPFPSPMHESEK", "length": 445, "header": "tr|A0AAA9SA92-1|A0AAA9SA92_BOVIN Isoform 1 of HHLA2 member of B7 family OS=Bos taurus OX=9913 GN=HHLA2 PE=4 SV=1 CANONICAL=A0AAA9SA92-1" }, "locus": { "chromosome": "1", "start_pos": 53120111, "end_pos": 53094660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096347.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096347.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083000.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083000.1" } ] } }, { "isoform_ac": "A0AAA9TUW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92/entry#A0AAA9TUW6-1", "sequence": { "sequence": "MKAQAVLAFFFTLIPSLCGPQDASFSHVSMNEQIVTGRLGEDVILPCSFESGPNVVIHWKNQDTNVYSYYRDSDQLEKQDPRYVNRISLFHGEIHNGNASLSFRRLTLQDEGIYVCYVGTSLGKITKKIVLKVGAFVTPVMKYEKNTTNSFLICNVLSVFPYPIITWKVDNNTSISENNGKEVGSLGPFHINSRVNITGSNSSYQCEIENPLLKQTWTGRWTRKDVLHKMQSENVLLSCKPENSFFPPNQDFTVTWYRVESGSALLLAYFKNSSQETLINQPRLSWKEELINSRDFSLTVKDLHLSDSGEYLCDISSNESTLLTSQTLHVEASPRAPAGIIVPVLVAVVSAVLLLSVAPRAVRSKRCIGFHRERHPPTNQDSSSAGTTEENVALSDYLPNTGTEDRS", "length": 407, "header": "tr|A0AAA9TUW6-1|A0AAA9TUW6_BOVIN Computationally mapped isoform of HHLA2 member of B7 family OS=Bos taurus OX=9913 GN=HHLA2 PE=4 SV=2 CANONICAL=A0AAA9SA92-1" }, "locus": { "chromosome": "1", "start_pos": 53110208, "end_pos": 53094660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107389.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107389.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101161.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101161.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101908484", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101908484", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" } ], "pmid": "" }, { "name": "positive regulation of activated T cell proliferation", "id": "GO:0042104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SA92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA92" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 126, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 172, "end_pos": 174 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 201, "end_pos": 203 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAA1-1", "uniprot_ac": "A0AAA9SAA1", "uniprot_id": "A0AAA9SAA1_BOVIN", "mass": { "chemical_mass": 8015.0, "monoisotopic_mass": 8015.0 }, "refseq": { "ac": "NP_001397341", "name": "small leucine-rich protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397341" }, "gene_names": [ { "name": "SMLR1", "type": "recommended", "evidence": [ { "id": "A0AAA9SAA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1" } ] }, { "name": "SMLR1", "type": "synonym", "evidence": [ { "id": "NP_001397341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397341" } ] } ], "protein_names": [ { "name": "Small leucine rich protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SAA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1/entry#names_and_taxonomy" } ] }, { "name": "small leucine-rich protein 1", "type": "synonym", "evidence": [ { "id": "NP_001397341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397341" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMLR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1", "locus": { "chromosome": "9", "start_pos": 68934584, "end_pos": 68925188, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059877", "url": "https://www.ensembl.org/id/ENSBTAG00000059877" } ] } } ], "crossref": [ { "id": "A0AAA9SAA1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "100848729", "url": "https://www.ncbi.nlm.nih.gov/gene/100848729", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:100848729", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848729", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFRTKLM", "url": "https://omabrowser.org/oma/group/YFRTKLM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "NP_001397341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001397341", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPVLSELLSELPGWFLFSGIFLPVTLLLLLLIAYFRIKLMEVNEELSQTPDHQHSLNAGSSPYQRKKRT", "length": 70, "header": "tr|A0AAA9SAA1-1|A0AAA9SAA1_BOVIN Isoform 1 of Small leucine rich protein 1 OS=Bos taurus OX=9913 GN=SMLR1 PE=4 SV=1 CANONICAL=A0AAA9SAA1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA1/entry#A0AAA9SAA1-1", "sequence": { "sequence": "MSPVLSELLSELPGWFLFSGIFLPVTLLLLLLIAYFRIKLMEVNEELSQTPDHQHSLNAGSSPYQRKKRT", "length": 70, "header": "tr|A0AAA9SAA1-1|A0AAA9SAA1_BOVIN Isoform 1 of Small leucine rich protein 1 OS=Bos taurus OX=9913 GN=SMLR1 PE=4 SV=1 CANONICAL=A0AAA9SAA1-1" }, "locus": { "chromosome": "9", "start_pos": 68931885, "end_pos": 68925279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094158.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094158.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080350.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080350.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848729", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848729", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "H3BR10-1", "protein_name": "Small leucine-rich protein 1", "gene_name": "SMLR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSKGRSPRRKQVQTQRKAALVLSVTPMVPVGSVWLAMSSVLSAFMRELPGWFLFFGVFLPVTLLLLLLIAYFRIKLIEVNEELSQNCDRQHNPKDGSSLYQRMKWT", "length": 107 }, "evidence": [ { "id": "A0AAA9SAA1", "url": "https://omabrowser.org/oma/group/A0AAA9SAA1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "J3QMJ4-1", "protein_name": "Small leucine-rich protein 1", "gene_name": "Smlr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSVLAIFLQELPGPVLVLGIFLPVTLLLLLLLAYFRIKLMAVEEELAHTSDRQNKFGSSLRKRMR", "length": 66 }, "evidence": [ { "id": "A0AAA9SAA1", "url": "https://omabrowser.org/oma/group/A0AAA9SAA1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAB5-1", "uniprot_ac": "A0AAA9SAB5", "uniprot_id": "A0AAA9SAB5_BOVIN", "mass": { "chemical_mass": 97418.0, "monoisotopic_mass": 97418.0 }, "refseq": {}, "gene_names": [ { "name": "FYB1", "type": "recommended", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ] } ], "protein_names": [ { "name": "FYN-binding protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#names_and_taxonomy" } ] }, { "name": "Adhesion and degranulation promoting adaptor protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#names_and_taxonomy" } ] }, { "name": "FYB-120/130", "type": "synonym", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#names_and_taxonomy" } ] }, { "name": "FYN-T-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#names_and_taxonomy" } ] }, { "name": "SLAP-130", "type": "synonym", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#names_and_taxonomy" } ] }, { "name": "SLP-76-associated phosphoprotein", "type": "synonym", "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5#function" }, { "database": "UniProtKB", "id": "ARBA00059917", "url": "https://www.uniprot.org/uniprotkb/ARBA00059917#function" }, { "database": "UniProtKB", "id": "A0AAA9TC11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC11#function" }, { "database": "UniProtKB", "id": "F6QWZ8", "url": "https://www.uniprot.org/uniprotkb/F6QWZ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FYB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5", "locus": { "chromosome": "20", "start_pos": 35332224, "end_pos": 35152760, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001492", "url": "https://www.ensembl.org/id/ENSBTAG00000001492" } ] } } ], "crossref": [ { "id": "A0AAA9SAB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00174", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00174", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11867", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11867", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16830", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16830", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16830:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16830:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QWZ8", "url": "https://www.uniprot.org/uniprotkb/F6QWZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QWZ8-1", "url": "https://www.uniprot.org/uniprotkb/F6QWZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQINLIYQCVKTGQTTGFKKGSTVCIANLHIHCPSYSIFGVAVCHAHQLFHKKMDGKADVKSLMAKFNTGGNPTEEVSVNNRPFKVPGQNSPSGVQAKKNLFNNQGNASPPAGLSNVPKFGSPKPPLGVKPSPEEKPDKEPKPPFLKPAGVSPRFGPQANSATRDSEVKAGFLKPVGPKPINLPKEDAKPAFPWPPGAKPSLPSVNQDHDLKPGPKPGSMPPALENEPKQVLSKLAGAKGKFLSASQDLDPKPLFPKPVFGQKPPMNTEDPQEDESPTKTAAPQRGPLVPLAAKAKSGPLKPAREEPENKEHGGETSVSPFPGVVLKPAANRGAPGGLPKNTEEKREDRKMDAAKNIFLNKITQEESAPGAPPAKFLKTPSKLTSTGPWSQNQDKEKGDKNSATPKQKPLPSLFTLGPPPPKPSRPPHVDLSKFRKATSGNSTNKGPMTFSTTALPPPPPSHPASQPPLPASHPTQLPAPSLPPRNIKPPLDLKGPVNEENQDSVMHSDGTGNLDEEQESEGETYEDIDTSKEKEKKREKEEKKRLELEKKEQKEREKKEQEIKKKFKLTGPIQVIHQAKACCDVKGGKNELSFKQGENIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKGCLSALSTRLLEDDQEVYDDVAEQENVSSHSQSGSGGMFPPPPDDDIYDGIEEEDAANGSTLQVEEKSNTWSWGILKMLKGKDDKKKSIREKPKDSESDNDEGSSFPSPPKQVDMGDEVYDDVDASDFPPPPIEISQGAKTKAEEKDPKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVAPSLSSKKWGNRDLQIKPGESLEVIQNTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND", "length": 890, "header": "tr|A0AAA9SAB5-1|A0AAA9SAB5_BOVIN Isoform 1 of FYN-binding protein 1 OS=Bos taurus OX=9913 GN=FYB1 PE=4 SV=1 CANONICAL=A0AAA9SAB5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#A0AAA9SAB5-1", "sequence": { "sequence": "MQINLIYQCVKTGQTTGFKKGSTVCIANLHIHCPSYSIFGVAVCHAHQLFHKKMDGKADVKSLMAKFNTGGNPTEEVSVNNRPFKVPGQNSPSGVQAKKNLFNNQGNASPPAGLSNVPKFGSPKPPLGVKPSPEEKPDKEPKPPFLKPAGVSPRFGPQANSATRDSEVKAGFLKPVGPKPINLPKEDAKPAFPWPPGAKPSLPSVNQDHDLKPGPKPGSMPPALENEPKQVLSKLAGAKGKFLSASQDLDPKPLFPKPVFGQKPPMNTEDPQEDESPTKTAAPQRGPLVPLAAKAKSGPLKPAREEPENKEHGGETSVSPFPGVVLKPAANRGAPGGLPKNTEEKREDRKMDAAKNIFLNKITQEESAPGAPPAKFLKTPSKLTSTGPWSQNQDKEKGDKNSATPKQKPLPSLFTLGPPPPKPSRPPHVDLSKFRKATSGNSTNKGPMTFSTTALPPPPPSHPASQPPLPASHPTQLPAPSLPPRNIKPPLDLKGPVNEENQDSVMHSDGTGNLDEEQESEGETYEDIDTSKEKEKKREKEEKKRLELEKKEQKEREKKEQEIKKKFKLTGPIQVIHQAKACCDVKGGKNELSFKQGENIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKGCLSALSTRLLEDDQEVYDDVAEQENVSSHSQSGSGGMFPPPPDDDIYDGIEEEDAANGSTLQVEEKSNTWSWGILKMLKGKDDKKKSIREKPKDSESDNDEGSSFPSPPKQVDMGDEVYDDVDASDFPPPPIEISQGAKTKAEEKDPKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVAPSLSSKKWGNRDLQIKPGESLEVIQNTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND", "length": 890, "header": "tr|A0AAA9SAB5-1|A0AAA9SAB5_BOVIN Isoform 1 of FYN-binding protein 1 OS=Bos taurus OX=9913 GN=FYB1 PE=4 SV=1 CANONICAL=A0AAA9SAB5-1" }, "locus": { "chromosome": "20", "start_pos": 35331220, "end_pos": 35161994, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130627.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130627.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079119.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079119.1" } ] } }, { "isoform_ac": "A0AAA9TC11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#A0AAA9TC11-1", "sequence": { "sequence": "MATLAEVFFYWSLVCGEREVTMMAPPLAMTQHPASIAAQHSSKGTPHHGLPHSHPLWSSSHSQQLSLPWDCSPIPMLLLSATVHFSGLASLFRDGKADVKSLMAKFNTGGNPTEEVSVNNRPFKVPGQNSPSGVQAKKNLFNNQGNASPPAGLSNVPKFGSPKPPLGVKPSPEEKPDKEPKPPFLKPAGVSPRFGPQANSATRDSEVKAGFLKPVGPKPINLPKEDAKPAFPWPPGAKPSLPSVNQDHDLKPGPKPGSMPPALENEPKQVLSKLAGAKGKFLSASQDLDPKPLFPKPVFGQKPPMNTEDPQEDESPTKTAAPQRGPLVPLAAKAKSGPLKPAREEPENKEHGGETSVSPFPGVVLKPAANRGAPGGLPKNTEEKREDRKMDAAKNIFLNKITQEESAPGAPPAKFLKTPSKLTSTGPWSQNQDKEKGDKNSATPKQKPLPSLFTLGPPPPKPSRPPHVDLSKFRKATSGNSTNKGPMTFSTTALPPPPPSHPASQPPLPASHPTQLPAPSLPPRNIKPPLDLKGPVNEENQDSVMHSDGTGNLDEEQESEGETYEDIDTSKEKEKKREKEEKKRLELEKKEQKEREKKEQEIKKKFKLTGPIQVIHQAKACCDVKGGKNELSFKQGENIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKGCLSALSTRLLEDDQEVYDDVAEQENVSSHSQSGSGGMFPPPPDDDIYDGIEEEDAANGFPSPPKQVDMGDEVYDDVDASDFPPPPIEISQGAKTKAEEKDPKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVAPSLSSKKWGNRDLQIKPGESLEVIQNTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND", "length": 883, "header": "tr|A0AAA9TC11-1|A0AAA9TC11_BOVIN Computationally mapped isoform of FYN-binding protein 1 OS=Bos taurus OX=9913 GN=FYB1 PE=4 SV=1 CANONICAL=A0AAA9SAB5-1" }, "locus": { "chromosome": "20", "start_pos": 35331220, "end_pos": 35152824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119137.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119137.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094375.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094375.1" } ] } }, { "isoform_ac": "F6QWZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5/entry#F6QWZ8-1", "sequence": { "sequence": "MNEPAAEKASWKSYSIFGVAVCHAHQLFHKKMDGKADVKSLMAKFNTGGNPTEEVSVNNRPFKVPGQNSPSGVQAKKNLFNNQGNASPPAGLSNVPKFGSPKPPLGVKPSPEEKPDKEPKPPFLKPAGVSPRFGPQANSATRDSEVKAGFLKPVGPKPINLPKEDAKPAFPWPPGAKPSLPSVNQDHDLKPGPKPGSMPPALENEPKQVLSKLAGAKGKFLSASQDLDPKPLFPKPVFGQKPPMNTEDPQEDESPTKTAAPQRGPLVPLAAKAKSGPLKPAREEPENKEHGGETSVSPFPGVVLKPAANRGAPGGLPKNTEEKREDRKMDAAKNIFLNKITQEESAPGAPPAKFLKTPSKLTSTGPWSQNQDKEKGDKNSATPKQKPLPSLFTLGPPPPKPSRPPHVDLSKFRKATSGNSTNKGPMTFSTTALPPPPPSHPASQPPLPASHPTQLPAPSLPPRNIKPPLDLKGPVNEENQDSVMHSDGTGNLDEEQESEGETYEDIDTSKEKEKKREKEEKKRLELEKKEQKEREKKEQEIKKKFKLTGPIQVIHQAKACCDVKGGKNELSFKQGENIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKGCLSALSTRLLEDDQEVYDDVAEQENVSSHSQSGSGGMFPPPPDDDIYDGIEEEDAANGFPSPPKQVDMGDEVYDDVDASDFPPPPIEISQGAKTKAEEKDPKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVAPSLSSKKWGNRDLQIKPGESLEVIQNTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND", "length": 822, "header": "tr|F6QWZ8-1|F6QWZ8_BOVIN Computationally mapped isoform of FYN-binding protein 1 OS=Bos taurus OX=9913 GN=FYB1 PE=4 SV=1 CANONICAL=A0AAA9SAB5-1" }, "locus": { "chromosome": "20", "start_pos": 35331220, "end_pos": 35159601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001953.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001953.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001953.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001953.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "pmid": "" }, { "name": "anchoring junction", "id": "GO:0070161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 667, "end_pos": 669, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB5" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 574, "end_pos": 635, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 441, "end_pos": 443 }, { "start_pos": 667, "end_pos": 669 }, { "start_pos": 699, "end_pos": 701 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAB7-1", "uniprot_ac": "A0AAA9SAB7", "uniprot_id": "A0AAA9SAB7_BOVIN", "mass": { "chemical_mass": 204193.0, "monoisotopic_mass": 204193.0 }, "refseq": { "ac": "XP_002691187", "name": "transmembrane protein 131 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691187" }, "gene_names": [ { "name": "TMEM131", "type": "recommended", "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" } ] }, { "name": "TMEM131", "type": "synonym", "evidence": [ { "id": "XP_002691187", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691187" } ] } ], "protein_names": [ { "name": "Transmembrane protein 131", "type": "synonym", "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 131 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_002691187", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691187" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM131", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7", "locus": { "chromosome": "11", "start_pos": 3112471, "end_pos": 3298376, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006744", "url": "https://www.ensembl.org/id/ENSBTAG00000006744" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006744", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540861", "url": "https://www.ncbi.nlm.nih.gov/gene/540861", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055435", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055435", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056311", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056311", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540861", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540861", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NQHTNRT", "url": "https://omabrowser.org/oma/group/NQHTNRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH73", "url": "https://www.orthodb.org/?gene=F1MH73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22050:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22050:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12371", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12371", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19532", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24495", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24495", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24498", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24498", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691187", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691187", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH73", "url": "https://www.uniprot.org/uniprotkb/F1MH73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH73-1", "url": "https://www.uniprot.org/uniprotkb/F1MH73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKRAGGGAAGSAAAASTSAVAGLEPAAGRGGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFIQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAVTVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNGSGYIFTLFFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGILSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRTTIISSLPEFEKSSLSDQSSVILASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPRVQPGIAMQEDAWDTDWDLHQSLFKGWMGIKENSGHKLSAMFEVNTDLQKNILSKVSAELSWPSLLSSPRLVRFPLTNTNCSSEEEIMLENPADVPIYIQFIPLALYSSPSIFVDKLISRFNLSKVAKIDLRTQEFQVFRNTAHPLQSSTGFTEGLSRHLVLNLILKPGEKKSVKVKFTPVHNRTVSSLIIIRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTEGMRLREPNFTLKRTFKVENTGQLPIHIETIEVSGYSCEGYGFKVVNCQEFALSANASKDIVILFTPDFTASRVIRELKFITASGSEFVFVLNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSASRPGAGSHKQCSPSVHPHSSHSNRNSADVENVRAKNSASASGRTNAQSASKASPLVFESHSMAQGHTAGRKSKGARQGQHSSQHHGHSPLEQHSPPPPPPVPQQQEPQPERLSPAPLAPPPHPEHPGSTRHSSEDSDITSLIEAMDKDFEHHDAPPLDVFTEQPPSPLSKSKGKGKPPQRKVKPPKKQEEKEKKGKGRALEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHENEMSQVKQKSKKVLNVKKEIPADVKPSCLELPYTAPLESKQRRNLPTKIPLPTTLTSGSKPRNSQKTKGTSKLVDSRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPPPTSPSPPAAPCPFTSRGSYSSIVHGSPGSDSKAKQPSGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSSKTDFSSSLGISHTPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQPSQRSWNELSSGPSYLWDSPATEPSPSWPASSSSPTHTATPILGSTSSLWSSTPFSSSIWSSSLHSTLPFTSPTSALPSISLMGPESAPAAHAPSAASPSDDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1876, "header": "tr|A0AAA9SAB7-1|A0AAA9SAB7_BOVIN Isoform 1 of Transmembrane protein 131 OS=Bos taurus OX=9913 GN=TMEM131 PE=3 SV=1 CANONICAL=A0AAA9SAB7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7/entry#A0AAA9SAB7-1", "sequence": { "sequence": "MGKRAGGGAAGSAAAASTSAVAGLEPAAGRGGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFIQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAVTVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNGSGYIFTLFFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGILSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRTTIISSLPEFEKSSLSDQSSVILASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPRVQPGIAMQEDAWDTDWDLHQSLFKGWMGIKENSGHKLSAMFEVNTDLQKNILSKVSAELSWPSLLSSPRLVRFPLTNTNCSSEEEIMLENPADVPIYIQFIPLALYSSPSIFVDKLISRFNLSKVAKIDLRTQEFQVFRNTAHPLQSSTGFTEGLSRHLVLNLILKPGEKKSVKVKFTPVHNRTVSSLIIIRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTEGMRLREPNFTLKRTFKVENTGQLPIHIETIEVSGYSCEGYGFKVVNCQEFALSANASKDIVILFTPDFTASRVIRELKFITASGSEFVFVLNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSASRPGAGSHKQCSPSVHPHSSHSNRNSADVENVRAKNSASASGRTNAQSASKASPLVFESHSMAQGHTAGRKSKGARQGQHSSQHHGHSPLEQHSPPPPPPVPQQQEPQPERLSPAPLAPPPHPEHPGSTRHSSEDSDITSLIEAMDKDFEHHDAPPLDVFTEQPPSPLSKSKGKGKPPQRKVKPPKKQEEKEKKGKGRALEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHENEMSQVKQKSKKVLNVKKEIPADVKPSCLELPYTAPLESKQRRNLPTKIPLPTTLTSGSKPRNSQKTKGTSKLVDSRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPPPTSPSPPAAPCPFTSRGSYSSIVHGSPGSDSKAKQPSGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSSKTDFSSSLGISHTPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQPSQRSWNELSSGPSYLWDSPATEPSPSWPASSSSPTHTATPILGSTSSLWSSTPFSSSIWSSSLHSTLPFTSPTSALPSISLMGPESAPAAHAPSAASPSDDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1876, "header": "tr|A0AAA9SAB7-1|A0AAA9SAB7_BOVIN Isoform 1 of Transmembrane protein 131 OS=Bos taurus OX=9913 GN=TMEM131 PE=3 SV=1 CANONICAL=A0AAA9SAB7-1" }, "locus": { "chromosome": "11", "start_pos": 3298177, "end_pos": 3113475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089177.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089177.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083030.1" } ] } }, { "isoform_ac": "A0AAA9TNN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7/entry#A0AAA9TNN4-1", "sequence": { "sequence": "MYVSLLNYLDAFVENQVDHKCTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAVTVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNGSGYIFTLFFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGILSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRTTIISSLPEFEKSSLSDQSSVILASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPRVQPGIAMQEDAWDTDWDLHQSLFKGWMGIKENSGHKLSAMFEVNTDLQKNILSKVSAELSWPSLLSSPRLVRFPLTNTNCSSEEEIMLENPADVPIYIQFIPLALYSSPSIFVDKLISRFNLSKVAKIDLRTQEFQVFRNTAHPLQSSTGFTEGLSRHLVLNLILKPGEKKSVKVKFTPVHNRTVSSLIIIRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTEGMRLREPNFTLKRTFKVENTGQLPIHIETIEVSGYSCEGYGFKVVNCQEFALSANASKDIVILFTPDFTASRVIRELKFITASGSEFVFVLNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSASRPGAGSHKQCSPSVHPHSSHSNRNSADVENVRAKNSASASGRTNAQSASKASPLVFESHSMAQGHTAGRKSKGARQGQHSSQHHGHSPLEQHSPPPPPPVPQQQEPQPERLSPAPLAPPPHPEHPGSTRHSSEDSDITSLIEAMDKDFEHHDAPPLDVFTEQPPSPLSKSKGKGKPPQRKVKPPKKQEEKEKKGKGRALEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHENEMSQVKQKSKKVLNVKKEIPADVKPSCLELPYTAPLESKQRRNLPTKIPLPTTLTSGSKPRNSQKTKGTSKLVDSRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPPPTSPSPPAAPCPFTSRGSYSSIVHGSPGSDSKAKQPSGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSSKTDFSSSLGISHTPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQPSQRSWNELSSGPSYLWDSPATEPSPSWPASSSSPTHTATPILGSTSSLWSSTPFSSSIWSSSLHSTLPFTSPTSALPSISLMGPESAPAAHAPSAASPSDDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1815, "header": "tr|A0AAA9TNN4-1|A0AAA9TNN4_BOVIN Computationally mapped isoform of Transmembrane protein 131 OS=Bos taurus OX=9913 GN=TMEM131 PE=3 SV=1 CANONICAL=A0AAA9SAB7-1" }, "locus": { "chromosome": "11", "start_pos": 3231609, "end_pos": 3113475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106162.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106162.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098651.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098651.1" } ] } }, { "isoform_ac": "A0AAA9TUS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7/entry#A0AAA9TUS4-1", "sequence": { "sequence": "MGKRAGGGAAGSAAAASTSAVAGLEPAAGRGGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFIQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAVTVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNGSGYIFTLFFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGILSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRTTIISSLPEFEKSSLSDQSSVILASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPRVQPGIAMQEDAWDTDWDLHQSLFKGWMGIKENSGHKLSAMFEVNTDLQKNILSKVSAELSWPSLLSSPRLVRFPLTNTNCSSEEEIMLENPADVPIYIQFIPLALYSSPSIFVDKLISRFNLSKVAKIDLRTQEFQVFRNTAHPLQSSTGFTEGLSRHLVLNLILKPGEKKSVKVKFTPVHNRTVSSLIIIRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTEGMRLREPNFTLKRTFKVENTGQLPIHIETIEVSGYSCEGYGFKVVNCQEFALSANASKDIVILFTPDFTASRVIRELKFITASGSEFVFVLNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSASRPGAGSHKQCSPSVHPHSSHSNRNSADVENVRAKNSASASGRTNAQSASKASPLVFESHSMAQGHTAGRKSKGARQGQHSSQHHGHSPLEQHSPPPPPPVPQQQEPQPERLSPAPLAPPPHPEHPGSTRHSSEDSDITSLIEAMDKDFEHHDAPPLDVFTEQPPSPLSKSKGKGKPPQRKVKPPKKQEEKEKKGKGRALEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHENEMSQVKQKSKKVLNVKKEIPADVKPSCLELPYTAPLESKQRRNLPTKIPLPTTLTSGSKPRNSQKTKGTSKLVDSRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPPPTSPSPPAAPCPFTSRGSYSSIVHGSPGSDSKAKQPSGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSSKTDFSSSLGISHTPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQPSQRSWNELSSGPSYLWDSPATEPSPSWPASSSSPTHTATPILGSTSSLWSSTPFSSSIWSSSLHSTLPFTSPTSALPSISLMGPESAPAAHAPSAASPSDDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1837, "header": "tr|A0AAA9TUS4-1|A0AAA9TUS4_BOVIN Computationally mapped isoform of Transmembrane protein 131 OS=Bos taurus OX=9913 GN=TMEM131 PE=3 SV=1 CANONICAL=A0AAA9SAB7-1" }, "locus": { "chromosome": "11", "start_pos": 3298177, "end_pos": 3113475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122038.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122038.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102379.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102379.1" } ] } }, { "isoform_ac": "F1MH73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7/entry#F1MH73-1", "sequence": { "sequence": "MMEGFYSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAVTVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNGSGYIFTLFFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGILSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRTTIISSLPEFEKSSLSDQSSVILASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPRVQPGIAMQEDAWDTDWDLHQSLFKGWMGIKENSGHKLSAMFEVNTDLQKNILSKVSAELSWPSLLSSPRLVRFPLTNTNCSSEEEIMLENPADVPIYIQFIPLALYSSPSIFVDKLISRFNLSKVAKIDLRTQEFQVFRNTAHPLQSSTGFTEGLSRHLVLNLILKPGEKKSVKVKFTPVHNRTVSSLIIIRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTEGMRLREPNFTLKRTFKVENTGQLPIHIETIEVSGYSCEGYGFKVVNCQEFALSANASKDIVILFTPDFTASRVIRELKFITASGSEFVFVLNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSASRPGAGSHKQCSPSVHPHSSHSNRNSADVENVRAKNSASASGRTNAQSASKASPLVFESHSMAQGHTAGRKSKGARQGQHSSQHHGHSPLEQHSPPPPPPVPQQQEPQPERLSPAPLAPPPHPEHPGSTRHSSEDSDITSLIEAMDKDFEHHDAPPLDVFTEQPPSPLSKSKGKGKPPQRKVKPPKKQEEKEKKGKGRALEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHENEMSQVKQKSKKVLNVKKEIPADVKPSCLELPYTAPLESKQRRNLPTKIPLPTTLTSGSKPRNSQKTKGTSKLVDSRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPPPTSPSPPAAPCPFTSRGSYSSIVHGSPGSDSKAKQPSGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSSKTDFSSSLGISHTPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQPSQRSWNELSSGPSYLWDSPATEPSPSWPASSSSPTHTATPILGSTSSLWSSTPFSSSIWSSSLHSTLPFTSPTSALPSISLMGPESAPAAHAPSAASPSDDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1787, "header": "tr|F1MH73-1|A0AAA9SAB7_BOVIN Computationally mapped isoform of Transmembrane protein 131 OS=Bos taurus OX=9913 GN=TMEM131 PE=3 SV=3 CANONICAL=A0AAA9SAB7-1" }, "locus": { "chromosome": "11", "start_pos": 3240790, "end_pos": 3113475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008872.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008872.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008872.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008872.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1656, "start_aa": "Thr", "end_pos": 1656, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1656", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 362, "start_aa": "Thr", "end_pos": 362, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr362", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540861", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540861", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZM29-1", "protein_name": "Transmembrane protein 131", "gene_name": "Tmem131", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKRAGGGAAAAAASASSGARLEPAAGRGGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFIQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPVINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSRDADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPVTLKASESKYTKVASISFDASRAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIQDSPADPVERPIYLTNTFSFAILIHDVLLPEEARTMFQVHNFSKPVLILPNESGYIFTLFFMPSTSSMHIDNNILLVTNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASSILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRSTVIASLPELEKSSLPDQSPVTLASGHFAVFRVKLTAKKLEGVHDGAIQITTDYEILTIPVKAVVAVGSLTCFPKHMVLPPSFPGKIVHQSLNVMNSFSQKVKIQQIRSLSEDVRFYYRRLRGNREDLEPGKKSKIANIYFDPGLQCGDHCYIGLPFLSKSEPKVQPGVAMQEDLWDADWEAHQSLFKAWMGIKENAGHRLNAMFEVNTDLQKNIISKVSAELSWPSVLSSPRLVRFPLTNTNCSSEEEISVENPADVPVYVQFIPLALYSNPSVFADKLVSRFNLSKVAKLDLRTLEFQVYRNSAHPLQSPTGFTEGLSRHFILNLILKPGEKKSVTVKFTPLHNRTVSSLIIVRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCIDRLKLREPNFTLKRTFKVENAGHLEIRVETIEISGYACEGYGFKVVNCQEFALSANASRDIVILFTPDFTASRVIRELKFVTSSGSEFVFVLNASLPYHMLAACAEALPRPNWELALYIIISGVMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLGCEHSHGRGFYSNSSSRPGTGSHRQCGTSVHPHSSHGSKNSADVDNVRTRNSSSMSSRTSPQAATSQSTSKTSPLVSEAAAATQGHTASRKSKGAKQGQHNSQHHSHSPLEQHSQPPPPVPQHQEPPPERLSPAPLTHPPHPERASTTRHSSEDSDITSLIEAMDKDFEHHDSPSLDVFTEQPPSPLSKNKGKGKSLQQRKAKPPKKQEEKEKRGKGKPQEEELKDTLADDDSSSTTTETSNPDTEPLLREDTEKHKGRPAMPEKQESELSQGKPKSKKLLNAKKEIPTDVKGGSFELPYTPSLENKQRRSLSKIPLPTTLTSGSKSRNPQKTKGTDKLVGSRPAALSKLLPNSQELSSTSSSEGEKDSPPPEWDAVPVHKPSSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPLPTAPCPFTSRGSYSSVVNSSGSDTKAKQPNGSKSKLTKAASLPGKNGNPTFAAVAAGYDKSPGGNGFAKISSNKSEFSSSLGISHIPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGAVFSKLSRSCSQSSQRSWNELSSGPSYLWDAPAADPSPSWPVPASSSSTTHTATSILGNTSGLWSTTPFSSSIWSSNINSNLPFSTPTNTLSGIGLMGTENSTPAHAPASSPADDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1873 }, "evidence": [ { "id": "A0AAA9SAB7", "url": "https://omabrowser.org/oma/group/A0AAA9SAB7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O70472-1", "protein_name": "Transmembrane protein 131", "gene_name": "Tmem131", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKRAGGAAAAAAAASTSSAAGLEPAAGRGGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFIQSESIIEVLRFDDGGLLQTETTLGLGSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPVTLKASESKYTKVASISFDASRAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIQDSPADPVERPIYLTNTFSFAILIHDVLLPEEARIMFQVHNFSQPVLILPNESGYIFTLFFMPSTSSMHIDNNILLVTNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASSILFAIINSNPIELAIKSWHIIGDGLSIELVATERGNRSTVIASLPELERSSLPDQSPVTLASGHFAVFRVKLTAKKLEGVHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNREDLEPGKKSKIANIYFDPGLQCGDHCYIGLPFLSKSEPKVQPGVAMQEDLWDADWDAHQSLFKAWMGIKENAGHRLNAMFEVNTDLQKNIVSKVSAELSWPSVLSSPRLLKFPLTNTNCSSEEEISLENPADVPVYVQFIPLALYSNPSVFADKLVSRFNLSKVAKLDLRTLEFQVYRNSAHPLQSPTGFTEGLSRHFILNLILKPGEKKSVKVKFTPLHNRTVSSLIIVRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCIDRLKLREPNFTLKRTFKVENTGQLEIRVETIEISGYACEGYGFKVVNCQEFALSANASRDIVILFTPDFTASRVIRELKFVTSSGSEFVFVLNASLPYHMLAACAEALPRPNWELALYIIISGVMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLGCEHSHGRGFYSNASSRPGTGSHRQCGTSVHPHSSHGSKNSADVDNVRTRNSSSMSSRTSPQAAASQSTSKTSPLVSETAAATQGHTASRKSRGAKQGQHSSQHHSHSHSPLEQHSQPPPPVPQHQEPPPERLSPAPLTHPSHPERASTTRHSSEDSDITSLIEAMDKDFDHHDSSPLDVFTEQPPSPMSKSKGKGKSLQQRKAKPPKKQEEKEKRGKGKPQEDELKDALADDDSSSTTTETSNPDTEPLLREDTEKHKGRPAVPEKQESELSQGKPKSKKLLNAKKEIPTDVKGSSFELPYTPSLENKQRRNLPTKIPLPTTLASGSKSRNPPKTKGTNKLVENRPVALSKFLPSSQELGNTSSSEGEKDSPPPEWDAVPVHKPSSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSLPTAPCPFTSRGSYSSVVNSSGSDTKAKQTSSSKSKLTKAASLPGKNGNPTFAAVAAGYDKSPGGNGFAKISSNKSDFSSSLGISHIPVDSDGSDSSGLWSPVSNPNSPDFTPLNSFSAFGNSFNLTGAVFSKLSRSCSQSSQRSWNEFNSGPSYLWDSPATDPSPSWPASSSSPTHTATSILGNSSGLWSTTPFSSSIWSSNINSNLPFSTPTNALSSISLMGTENSAAAHTPSASGPADDLGQTYNPWRIWSPTVGRRSSDPWSNSHFPHEN", "length": 1877 }, "evidence": [ { "id": "A0AAA9SAB7", "url": "https://omabrowser.org/oma/group/A0AAA9SAB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92545-1", "protein_name": "Transmembrane protein 131", "gene_name": "TMEM131", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKLEIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTMFKVHNFSKPVLILPNESGYIFTLLFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVLPPKIEERFIDFGVLSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVAVERGNRTTIISSLPEFEKSSLSDQSSVTLASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIPVKAVIAVGSLTCFPKHVVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPKVQPGVAMQEDMWDADWDLHQSLFKGWTGIKENSGHRLSAIFEVNTDLQKNIISKITAELSWPSILSSPRHLKFPLTNTNCSSEEEITLENPADVPVYVQFIPLALYSNPSVFVDKLVSRFNLSKVAKIDLRTLEFQVFRNSAHPLQSSTGFMEGLSRHLILNLILKPGEKKSVKVKFTPVHNRTVSSLIIVRNNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTDSLKLREPNFTLKRTFKVENTGQLQIHIETIEISGYSCEGYGFKVVNCQEFTLSANASRDIIILFTPDFTASRVIRELKFITTSGSEFVFILNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSSSRPSAGSHKQCGPSVHPHSSHSNRNSADVENVRAKNSSSTSSRTSAQAASSQSANKTSPLVLDSNTVTQGHTAGRKSKGAKQSQHGSQHHAHSPLEQHPQPPLPPPVPQPQEPQPERLSPAPLAHPSHPERASSARHSSEDSDITSLIEAMDKDFDHHDSPALEVFTEQPPSPLPKSKGKGKPLQRKVKPPKKQEEKEKKGKGKPQEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHESEMSQVKQKSKKLLNIKKEIPTDVKPSSLELPYTPPLESKQRRNLPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDNRPPALAKFLPNSQELGNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSPPAAPCPFVARGSYSSIVNSSSSSDPKIKQPNGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSSNKTGFSSSLGISHAPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSKLGLSRSCNQASQRSWNEFNSGPSYLWESPATDPSPSWPASSGSPTHTATSVLGNTSGLWSTTPFSSSIWSSNLSSALPFTTPANTLASIGLMGTENSPAPHAPSTSSPADDLGQTYNPWRIWSPTIGRRSSDPWSNSHFPHEN", "length": 1883 }, "evidence": [ { "id": "A0AAA9SAB7", "url": "https://omabrowser.org/oma/group/A0AAA9SAB7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V7H4-1", "protein_name": "Transmembrane protein 131 homolog", "gene_name": "Tmem131", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPTQVQMRPLLRIFAEPILLILIFLFTLGAKGEKVLQETFLGLQEAPIHDLGDLRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADLLIHTSFGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMYNPHERPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIKVAEQELDIFIPVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKLDVRNDESRQLFGSYLRQIPGLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTSPGADQPFTVLVRAEIFHGGLTFDRNATRFVTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEVTLVGDPRILIQPDESVELLRLNLLNDQVPFKSFLRIETNVTVFKLPLVSCSGRLHVSTQPIVLNFRQESLEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNWFFKHPKTVYSQSTFLGCRATAIGHPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADATFGTLKVWTPYEVIRVRVKFEASVGHLEIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGISFALPVGLRFKDFNAKGTTIAPQTLTKVGRIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGNGNSGVINNNLLYDGVELRQRTELFRQLRRQLSSMSLTLHSEELPPLELDFSITIEWPKLVQFQPIPPTPAIEVGQVQRQWITLTNPSQSPLLLDYFLSDPAFARRTQLSLPHEVIDVSSTSCYLTDKEVFSLPEAGDPILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGCQSGNEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASLLVRPGWESSLKNAALVVLLASFGLVLVAAVFDAKAIMVQQNAYDAARNKGPLQPTFNLRNIVKLQAEEAAAKAESVQQQQKVKNGQLKELRKRTVVNSTNSKSKSKSSWSPWSMDMNALSKHLQKAKPKTVVSTPVTPPAASAPAAAPVPLPEAKPVKKSSTPSPQGVPISVQVRPQKKVKPTPAVVLGTTKPKQEVSTPVADQHEKSLAKSSPPQQENISPKPNKPPEQRVLKEQNGSAKKMGKTPGRERERERRSKDQKLTNGTGAGVGFRKPERKQRQKLNFGQTTNSTSPPESPDALKCISNPWETSSRVSFRDVLRTPQMAPTDNGFDWNHATSSSDLGPIGDNRKNATPPMVTSLWEPLSATASNSLFANTEVDFITPDAIYEQREREKPQWEQRSDLVMRQQLLLQQPQKLEFQLRQQEKISLLANMDPSNWATNWSPLGYSTWPNATAGIGVMRPPPGLEQSARQTHNLAQEQVSAGPASGTGAALHGESLPTQYDPFTSPSSIWSDTWRQSSQRNNHNHMN", "length": 1567 }, "evidence": [ { "id": "A0AAA9SAB7", "url": "https://omabrowser.org/oma/group/A0AAA9SAB7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "collagen biosynthetic process", "id": "GO:0032964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032964", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1011, "end_pos": 1013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1058, "end_pos": 1060, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1095, "end_pos": 1097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1542, "end_pos": 1544, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1725, "end_pos": 1727, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 599, "end_pos": 601, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 885, "end_pos": 887, "annotation": "n_glycosylation_sequon" }, { "start_pos": 946, "end_pos": 948, "annotation": "n_glycosylation_sequon" }, { "start_pos": 958, "end_pos": 960, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" }, { "id": "PF24495", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24495" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TMEM131 second Ig-like", "eco_id": "ECO_0000259", "start_pos": 208, "end_pos": 297, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" }, { "id": "PF24501", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24501" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TMEM131L fifth Ig-like", "eco_id": "ECO_0000259", "start_pos": 1022, "end_pos": 1086, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" }, { "id": "PF24499", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24499" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TMEM131L fourth Ig-like", "eco_id": "ECO_0000259", "start_pos": 835, "end_pos": 971, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" }, { "id": "PF24498", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24498" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TMEM131L third Ig-like", "eco_id": "ECO_0000259", "start_pos": 435, "end_pos": 534, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" }, { "id": "PF12371", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12371" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transmembrane protein 131-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 108, "end_pos": 190, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB7" }, { "id": "PF19532", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19532" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transmembrane protein 131-like second Ig-like", "eco_id": "ECO_0000259", "start_pos": 341, "end_pos": 391, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 362, 1656 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1011, "end_pos": 1013 }, { "start_pos": 1058, "end_pos": 1060 }, { "start_pos": 1095, "end_pos": 1097 }, { "start_pos": 1542, "end_pos": 1544 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 1725, "end_pos": 1727 }, { "start_pos": 189, "end_pos": 191 }, { "start_pos": 222, "end_pos": 224 }, { "start_pos": 289, "end_pos": 291 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 494, "end_pos": 496 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 599, "end_pos": 601 }, { "start_pos": 843, "end_pos": 845 }, { "start_pos": 885, "end_pos": 887 }, { "start_pos": 946, "end_pos": 948 }, { "start_pos": 958, "end_pos": 960 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAB9-1", "uniprot_ac": "A0AAA9SAB9", "uniprot_id": "A0AAA9SAB9_BOVIN", "mass": { "chemical_mass": 11060.0, "monoisotopic_mass": 11060.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SAB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SAB9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07699", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07699", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "PKFPPSVTLFPPSTEELSTYTATLVCLISDFYPGNVTVAWKADGSPVTRGVVTSQASQQSSSKYVASSYLTLTGSEWKPKSSYSCEVTHEGSTVTKTVKPSACS", "length": 104, "header": "tr|A0AAA9SAB9-1|A0AAA9SAB9_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SAB9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9/entry#A0AAA9SAB9-1", "sequence": { "sequence": "PKFPPSVTLFPPSTEELSTYTATLVCLISDFYPGNVTVAWKADGSPVTRGVVTSQASQQSSSKYVASSYLTLTGSEWKPKSSYSCEVTHEGSTVTKTVKPSACS", "length": 104, "header": "tr|A0AAA9SAB9-1|A0AAA9SAB9_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SAB9-1" }, "locus": { "chromosome": "17", "start_pos": 71937668, "end_pos": 71937357, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114054.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114054.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082277.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB9" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 99, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 35, "end_pos": 37 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAC2-1", "uniprot_ac": "A0AAA9SAC2", "uniprot_id": "A0AAA9SAC2_BOVIN", "mass": { "chemical_mass": 39793.0, "monoisotopic_mass": 39793.0 }, "refseq": { "ac": "XP_005214454", "name": "ankyrin repeat domain-containing protein 16 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214454" }, "gene_names": [ { "name": "ANKRD16", "type": "recommended", "evidence": [ { "id": "A0AAA9SAC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2" } ] }, { "name": "ANKRD16", "type": "synonym", "evidence": [ { "id": "XP_005214454", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214454" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain-containing protein 16", "type": "recommended", "evidence": [ { "id": "A0AAA9SAC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 16 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214454", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214454" } ] } ], "function": [ { "annotation": "Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI93#function" }, { "database": "UniProtKB", "id": "ARBA00053725", "url": "https://www.uniprot.org/uniprotkb/ARBA00053725#function" }, { "database": "UniProtKB", "id": "A0AAA9TYC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC0#function" }, { "database": "UniProtKB", "id": "A0AAA9SAC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2#function" }, { "database": "UniProtKB", "id": "A0AAA9TAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH4#function" }, { "database": "UniProtKB", "id": "G5E660", "url": "https://www.uniprot.org/uniprotkb/G5E660#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2", "locus": { "chromosome": "13", "start_pos": 42905552, "end_pos": 42879702, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039071", "url": "https://www.ensembl.org/id/ENSBTAG00000039071" } ] } } ], "crossref": [ { "id": "A0AAA9SAC2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039071", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039071", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507779", "url": "https://www.ncbi.nlm.nih.gov/gene/507779", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G5E660", "url": "https://www.orthodb.org/?gene=G5E660", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24173:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24173:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198:SF185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198:SF185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214454", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214454", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E660", "url": "https://www.uniprot.org/uniprotkb/G5E660", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E660-1", "url": "https://www.uniprot.org/uniprotkb/G5E660-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPADPRRLCRLVQDGRLCTLREELQAAGHAGCAGPAGDTLLHCAARHGRRDVLAYLVEAWDLDIEAANRDYKRPLHEAASMGHRNCVRYLLGRRAAVDCLKKADWTPLMMACTRRNLEVIRDLVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLAVCPSAWRTESKIGRTPLHTAAMHGCLEAVEVLLQRCQYEPDCRDRCGLTPFMDAVQCGHTDVARLLLKKHKACVSAEDSLGAQAIHRAAVTGQDEAIRFLVSELGVDVDARAGSTHLTALHFAAKEGHVSTVQTLLSLGADINSKDERNRSAYSALNVSSVRDPPPPQPPRPPDREDPRLGCDSAPGPPRPPASFGSVEEQSRS", "length": 364, "header": "tr|A0AAA9SAC2-1|A0AAA9SAC2_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 16 OS=Bos taurus OX=9913 GN=ANKRD16 PE=4 SV=1 CANONICAL=A0AAA9SAC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2/entry#A0AAA9SAC2-1", "sequence": { "sequence": "MAAPADPRRLCRLVQDGRLCTLREELQAAGHAGCAGPAGDTLLHCAARHGRRDVLAYLVEAWDLDIEAANRDYKRPLHEAASMGHRNCVRYLLGRRAAVDCLKKADWTPLMMACTRRNLEVIRDLVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLAVCPSAWRTESKIGRTPLHTAAMHGCLEAVEVLLQRCQYEPDCRDRCGLTPFMDAVQCGHTDVARLLLKKHKACVSAEDSLGAQAIHRAAVTGQDEAIRFLVSELGVDVDARAGSTHLTALHFAAKEGHVSTVQTLLSLGADINSKDERNRSAYSALNVSSVRDPPPPQPPRPPDREDPRLGCDSAPGPPRPPASFGSVEEQSRS", "length": 364, "header": "tr|A0AAA9SAC2-1|A0AAA9SAC2_BOVIN Isoform 1 of Ankyrin repeat domain-containing protein 16 OS=Bos taurus OX=9913 GN=ANKRD16 PE=4 SV=1 CANONICAL=A0AAA9SAC2-1" }, "locus": { "chromosome": "13", "start_pos": 42904949, "end_pos": 42879712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124058.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124058.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080377.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080377.1" } ] } }, { "isoform_ac": "A0AAA9SI93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2/entry#A0AAA9SI93-1", "sequence": { "sequence": "MAAPADPRRLCRLVQDGRLCTLREELQAAGHAGCAGPAGDTLLHCAARHGRRDVLAYLVEAWDLDIEAANRDYKRPLHEAASMGHRNCVRYLLGRRAAVDCLKKADWTPLMMACTRRNLEVIRDLVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLAVCPSAWRTESKIGRTPLHTAAMHGCLEAVEVLLQRCQYEPDCRDRCGLTPFMDAVQCGHTDVARLLLKKHKACVSAEDSLGAQAIHRAAVTGQDEAIRFLVSELGVDVDARAGSTHLTALHFAAKPCTWPARGSTQPVSSSSAPGS", "length": 306, "header": "tr|A0AAA9SI93-1|A0AAA9SI93_BOVIN Computationally mapped isoform of Ankyrin repeat domain-containing protein 16 OS=Bos taurus OX=9913 GN=ANKRD16 PE=4 SV=1 CANONICAL=A0AAA9SAC2-1" }, "locus": { "chromosome": "13", "start_pos": 42892856, "end_pos": 42879712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130375.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130375.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085955.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085955.1" } ] } }, { "isoform_ac": "A0AAA9TAH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2/entry#A0AAA9TAH4-1", "sequence": { "sequence": "MAAPADPRRLCRLVQDGRLCTLREELQAAGHAGCAGPAGDTLLHCAARHGRRDVLAYLVEAWDLDIEAANRDYKRPLHEAASMGHRNCVRYLLGRRAAVDCLKKADWTPLMMACTRRNLEVIRDLVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLAVCPSAWRTESKIGRTPLHTAAMHGCLEAVEVLLQRCQYEPDCRDRCGLTPFMDAVQCGHTDVARLLLKKHKACVSAEDSLGAQAIHRAAVTGQDEAIRFLVSELGVDVDARAGSTHLTALHFAAKEGHVSTVQTLLSLGADINSKDERNRSGDMALIPGCRRSHGEGNGNPLQHSCLGNPRTEEPDGIQSMASHRVRYD", "length": 359, "header": "tr|A0AAA9TAH4-1|A0AAA9TAH4_BOVIN Computationally mapped isoform of Ankyrin repeat domain-containing protein 16 OS=Bos taurus OX=9913 GN=ANKRD16 PE=4 SV=1 CANONICAL=A0AAA9SAC2-1" }, "locus": { "chromosome": "13", "start_pos": 42894414, "end_pos": 42879712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123750.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123750.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093005.1" } ] } }, { "isoform_ac": "A0AAA9TYC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2/entry#A0AAA9TYC0-1", "sequence": { "sequence": "MAAPADPRRLCRLVQDGRLCTLREELQAAGHAGCAGPAGDTLLHCAARHGRRDVLAYLVEAWDLDIEAANRDYKRPLHEAASMGHRNCVRYLLGRRAAVDCLKKADWTPLMMACTRRNLEVIRDLVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLAVCPSAWRTESKIGRTPLHTAAMHGCLEAVEVLLQRCQYEPDCRDRCGLTPFMDAVQCGHTDVARLLLKKHKACVSAEDSLGAQAIHRAAVTGQDEAIRFLVSELGVDVDARAGSTHLTALHFAAKEGHVSTVQTLLSLGADINSKDERNRSGGGPPPALGMRRLASWLDDSPLHSQTLSRVSDSLFLPSSGLDDGDEVCVWNP", "length": 363, "header": "tr|A0AAA9TYC0-1|A0AAA9TYC0_BOVIN Computationally mapped isoform of Ankyrin repeat domain-containing protein 16 OS=Bos taurus OX=9913 GN=ANKRD16 PE=4 SV=1 CANONICAL=A0AAA9SAC2-1" }, "locus": { "chromosome": "13", "start_pos": 42893216, "end_pos": 42879712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125793.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125793.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101672.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101672.1" } ] } }, { "isoform_ac": "G5E660-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2/entry#G5E660-1", "sequence": { "sequence": "MAAPADPRRLCRLVQDGRLCTLREELQAAGHAGCAGPAGDTLLHCAARHGRRDVLAYLVEAWDLDIEAANRDYKRPLHEAASMGHRNCVRYLLGRRAAVDCLKKADWTPLMMACTRRNLEVIRDLVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLAVCPSAWRTESKIGRTPLHTAAMHGCLEAVEVLLQRCQYEPDCRDRCGLTPFMDAVQCGHTDVARLLLKKHKACVSAEDSLGAQAIHRAAVTGQDEAIRFLVSELGVDVDARAGSTHLTALHFAAKEGHVSTVQTLLSLGADINSKDERNRSALHLACAGQHAACVQFLLSSGLQDSPDVTGTLAQHLTRSPNVLQCFNHSTM", "length": 362, "header": "tr|G5E660-1|G5E660_BOVIN Computationally mapped isoform of Ankyrin repeat domain-containing protein 16 OS=Bos taurus OX=9913 GN=ANKRD16 PE=4 SV=3 CANONICAL=A0AAA9SAC2-1" }, "locus": { "chromosome": "13", "start_pos": 42892942, "end_pos": 42879712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055083.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055083.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047681.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047681.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 309, "end_pos": 311 }, { "start_pos": 317, "end_pos": 319 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAC3-1", "uniprot_ac": "A0AAA9SAC3", "uniprot_id": "A0AAA9SAC3_BOVIN", "mass": { "chemical_mass": 21740.0, "monoisotopic_mass": 21740.0 }, "refseq": { "ac": "XP_059733095", "name": "SIGLEC family-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733095" }, "gene_names": [ { "name": "SIGLECL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3" } ] }, { "name": "SIGLECL1", "type": "synonym", "evidence": [ { "id": "XP_059733095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733095" } ] } ], "protein_names": [ { "name": "SIGLEC family like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SAC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3/entry#names_and_taxonomy" } ] }, { "name": "SIGLEC family-like protein 1", "type": "synonym", "evidence": [ { "id": "XP_059733095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733095" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SIGLECL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3", "locus": { "chromosome": "18", "start_pos": 57361531, "end_pos": 57346540, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065998", "url": "https://www.ensembl.org/id/ENSBTAG00000065998" } ] } } ], "crossref": [ { "id": "A0AAA9SAC3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAC3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112442407", "url": "https://www.ncbi.nlm.nih.gov/gene/112442407", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112442407", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112442407", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12035:SF113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12035:SF113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059733095", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733095", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPGLRLAPTRLLDSSCSLKKTLQCSCSFRGTPMPSVQWWVGGTPVAMNHTGFRVTSTTLGPWANSTIHLTKLPETGTSLLCEGRNPEGTHALTILLKSGRSPLVAQTFMKGLIRGVFYGAIGVTLLFLCLVPLIAKHIRMKQAKKIAAMKAEKSPKRARQGLETSLRLKEPGKSRVTPSPEQQILDPSPQTSKKSRIN", "length": 200, "header": "tr|A0AAA9SAC3-1|A0AAA9SAC3_BOVIN Isoform 1 of SIGLEC family like 1 OS=Bos taurus OX=9913 GN=SIGLECL1 PE=4 SV=1 CANONICAL=A0AAA9SAC3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3/entry#A0AAA9SAC3-1", "sequence": { "sequence": "MAPPGLRLAPTRLLDSSCSLKKTLQCSCSFRGTPMPSVQWWVGGTPVAMNHTGFRVTSTTLGPWANSTIHLTKLPETGTSLLCEGRNPEGTHALTILLKSGRSPLVAQTFMKGLIRGVFYGAIGVTLLFLCLVPLIAKHIRMKQAKKIAAMKAEKSPKRARQGLETSLRLKEPGKSRVTPSPEQQILDPSPQTSKKSRIN", "length": 200, "header": "tr|A0AAA9SAC3-1|A0AAA9SAC3_BOVIN Isoform 1 of SIGLEC family like 1 OS=Bos taurus OX=9913 GN=SIGLECL1 PE=4 SV=1 CANONICAL=A0AAA9SAC3-1" }, "locus": { "chromosome": "18", "start_pos": 57361239, "end_pos": 57355674, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125162.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125162.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080859.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080859.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 45, "start_aa": "Thr", "end_pos": 45, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:112442407", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112442407", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 45 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 50, "end_pos": 52 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAG8-1", "uniprot_ac": "A0AAA9SAG8", "uniprot_id": "A0AAA9SAG8_BOVIN", "mass": { "chemical_mass": 20288.0, "monoisotopic_mass": 20288.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC12", "type": "recommended", "evidence": [ { "id": "A0AAA9SAG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 12", "type": "synonym", "evidence": [ { "id": "A0AAA9SAG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8", "locus": { "chromosome": "22", "start_pos": 52585071, "end_pos": 52546385, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011311", "url": "https://www.ensembl.org/id/ENSBTAG00000011311" } ] } } ], "crossref": [ { "id": "A0AAA9SAG8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31551:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31551:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08315", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08315", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRDRCRTVFRPSATITPGPLSFPTSATPSSLRSEEGPWWPRDKEDGEPNTKQLREGEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLEKRTQRAIAELIRERLKGQEENLASAVATTAATEPEACDSD", "length": 178, "header": "tr|A0AAA9SAG8-1|A0AAA9SAG8_BOVIN Isoform 1 of Coiled-coil domain containing 12 OS=Bos taurus OX=9913 GN=CCDC12 PE=4 SV=1 CANONICAL=A0AAA9SAG8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8/entry#A0AAA9SAG8-1", "sequence": { "sequence": "MNRDRCRTVFRPSATITPGPLSFPTSATPSSLRSEEGPWWPRDKEDGEPNTKQLREGEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLEKRTQRAIAELIRERLKGQEENLASAVATTAATEPEACDSD", "length": 178, "header": "tr|A0AAA9SAG8-1|A0AAA9SAG8_BOVIN Isoform 1 of Coiled-coil domain containing 12 OS=Bos taurus OX=9913 GN=CCDC12 PE=4 SV=1 CANONICAL=A0AAA9SAG8-1" }, "locus": { "chromosome": "22", "start_pos": 52584765, "end_pos": 52547107, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114134.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114134.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079170.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079170.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 28, "start_aa": "Thr", "end_pos": 28, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 28 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAI6-1", "uniprot_ac": "A0AAA9SAI6", "uniprot_id": "A0AAA9SAI6_BOVIN", "mass": { "chemical_mass": 34695.0, "monoisotopic_mass": 34695.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SAI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SAI6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGNDSFVTEFILLGLTDQPDLQLPLLFLFLGMYIVTVLGNLGLIILIVLNSHLHTPMYFFLFNLSSIDICYSSVFTPKMLLNFISKKNIISYTGCMTQLYFYCFFVISECYLLTSMAYDRYVAICKPLLYNVVMSPKVCSSLMLASYLMAFSGAMVHTGCMLRLNFCDANTINHFFCDILPLLQLSCTSTYINELGMFIMAGINIIVPSITIFVSYGLIFSNIFHISSMEGRSKALSTCSSHIIAVSLFFGSMSFVYLKPSAGCMDERSISSVFYTNVVAMRTPLFYSFRNKDVKTALRKTVSGIQF", "length": 309, "header": "tr|A0AAA9SAI6-1|A0AAA9SAI6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SAI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6/entry#A0AAA9SAI6-1", "sequence": { "sequence": "MAPGNDSFVTEFILLGLTDQPDLQLPLLFLFLGMYIVTVLGNLGLIILIVLNSHLHTPMYFFLFNLSSIDICYSSVFTPKMLLNFISKKNIISYTGCMTQLYFYCFFVISECYLLTSMAYDRYVAICKPLLYNVVMSPKVCSSLMLASYLMAFSGAMVHTGCMLRLNFCDANTINHFFCDILPLLQLSCTSTYINELGMFIMAGINIIVPSITIFVSYGLIFSNIFHISSMEGRSKALSTCSSHIIAVSLFFGSMSFVYLKPSAGCMDERSISSVFYTNVVAMRTPLFYSFRNKDVKTALRKTVSGIQF", "length": 309, "header": "tr|A0AAA9SAI6-1|A0AAA9SAI6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SAI6-1" }, "locus": { "chromosome": "29", "start_pos": 27122291, "end_pos": 27109045, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128801.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128801.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080457.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080457.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAI9-1", "uniprot_ac": "A0AAA9SAI9", "uniprot_id": "A0AAA9SAI9_BOVIN", "mass": { "chemical_mass": 90319.0, "monoisotopic_mass": 90319.0 }, "refseq": {}, "gene_names": [ { "name": "ARHGAP24", "type": "recommended", "evidence": [ { "id": "A0AAA9SAI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 24", "type": "recommended", "evidence": [ { "id": "A0AAA9SAI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9/entry#names_and_taxonomy" } ] }, { "name": "Rho-type GTPase-activating protein 24", "type": "synonym", "evidence": [ { "id": "A0AAA9SAI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9#function" }, { "database": "UniProtKB", "id": "ARBA00058502", "url": "https://www.uniprot.org/uniprotkb/ARBA00058502#function" }, { "database": "UniProtKB", "id": "A0AAA9T7B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7B0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9", "locus": { "chromosome": "6", "start_pos": 100887281, "end_pos": 100005717, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003959", "url": "https://www.ensembl.org/id/ENSBTAG00000003959" } ] } } ], "crossref": [ { "id": "A0AAA9SAI9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003959", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003959", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04390", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04390", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13379", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13379", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539902", "url": "https://www.ncbi.nlm.nih.gov/gene/539902", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QNAMKCG", "url": "https://omabrowser.org/oma/group/QNAMKCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MHI2", "url": "https://www.orthodb.org/?gene=F1MHI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15228:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15228:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7B0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7B0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHI2", "url": "https://www.uniprot.org/uniprotkb/F1MHI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHI2-1", "url": "https://www.uniprot.org/uniprotkb/F1MHI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGARTELSALLSIHSVFLEEAQRCIEKYQDCQERERKPLATAGIEQRKSISLIMEENNDSMENSPQGPGRNNAVKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVLEHPCNEESPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIGKHDRLFPKDAELQSKPQDGVSNNNNDLQKKALMGQLQNKENNNTNDSPVRRCSWDKPESPQRSSMDNGSPTALPGSKTNSPRNSIHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEALEKAQTTPNGSLQARRTSSLKGSGTKMGTHSVQNGTVRMGILNSDTLGNPGNGRSMSWLPNGYVTLRDNKQKEQAGESGQHNRLSTYDNVHQQFSAMSLDDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPADYENKSDRRSVGGRSSRATSSSDNSETFVSNNTSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 803, "header": "tr|A0AAA9SAI9-1|A0AAA9SAI9_BOVIN Isoform 1 of Rho GTPase-activating protein 24 OS=Bos taurus OX=9913 GN=ARHGAP24 PE=4 SV=1 CANONICAL=A0AAA9SAI9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9/entry#A0AAA9SAI9-1", "sequence": { "sequence": "MLGARTELSALLSIHSVFLEEAQRCIEKYQDCQERERKPLATAGIEQRKSISLIMEENNDSMENSPQGPGRNNAVKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVLEHPCNEESPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIGKHDRLFPKDAELQSKPQDGVSNNNNDLQKKALMGQLQNKENNNTNDSPVRRCSWDKPESPQRSSMDNGSPTALPGSKTNSPRNSIHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEALEKAQTTPNGSLQARRTSSLKGSGTKMGTHSVQNGTVRMGILNSDTLGNPGNGRSMSWLPNGYVTLRDNKQKEQAGESGQHNRLSTYDNVHQQFSAMSLDDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPADYENKSDRRSVGGRSSRATSSSDNSETFVSNNTSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 803, "header": "tr|A0AAA9SAI9-1|A0AAA9SAI9_BOVIN Isoform 1 of Rho GTPase-activating protein 24 OS=Bos taurus OX=9913 GN=ARHGAP24 PE=4 SV=1 CANONICAL=A0AAA9SAI9-1" }, "locus": { "chromosome": "6", "start_pos": 100886779, "end_pos": 100005738, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101541.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101541.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082355.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082355.1" } ] } }, { "isoform_ac": "A0AAA9T7B0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9/entry#A0AAA9T7B0-1", "sequence": { "sequence": "MKAGGKSISLIMEENNDSMENSPQGPGRNNAVKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVLEHPCNEESPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIGKHDRLFPKDAELQSKPQDGVSNNNNDLQKKALMGQLQNKENNNTNDSPVRRCSWDKPESPQRSSMDNGSPTALPGSKTNSPRNSIHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEALEKAQTTPNGSLQARRTSSLKGSGTKMGTHSVQNGTVRMGILNSDTLGNPGNGRSMSWLPNGYVTLRDNKQKEQAGESGQHNRLSTYDNVHQQFSAMSLDDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPADYENKSDRRSVGGRSSRATSSSDNSETFVSNNTSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 760, "header": "tr|A0AAA9T7B0-1|A0AAA9T7B0_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 24 OS=Bos taurus OX=9913 GN=ARHGAP24 PE=4 SV=1 CANONICAL=A0AAA9SAI9-1" }, "locus": { "chromosome": "6", "start_pos": 100886779, "end_pos": 100430510, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109012.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109012.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091716.1" } ] } }, { "isoform_ac": "A0AAA9TRJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9/entry#A0AAA9TRJ3-1", "sequence": { "sequence": "MMPEDRNTGERPSGALASTTFIPKTTYRRIKRCFSFRKGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIGKHDRLFPKDAELQSKPQDGVSNNNNDLQKKALMGQLQNKENNNTNDSPVRRCSWDKPESPQRSSMDNGSPTALPGSKTNSPRNSIHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEALEKAQTTPNGSLQARRTSSLKGSGTKMGTHSVQNGTVRMGILNSDTLGNPGNGRSMSWLPNGYVTLRDNKQKEQAGESGQHNRLSTYDNVHQQFSAMSLDDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPADYENKSDRRSVGGRSSRATSSSDNSETFVSNNTSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 657, "header": "tr|A0AAA9TRJ3-1|A0AAA9TRJ3_BOVIN Computationally mapped isoform of Rho GTPase activating protein 24 OS=Bos taurus OX=9913 GN=ARHGAP24 PE=4 SV=1 CANONICAL=A0AAA9SAI9-1" }, "locus": { "chromosome": "6", "start_pos": 100886779, "end_pos": 100822251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097415.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097415.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101198.1" } ] } }, { "isoform_ac": "F1MHI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9/entry#F1MHI2-1", "sequence": { "sequence": "MTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMIGKHDRLFPKDAELQSKPQDGVSNNNNDLQKKALMGQLQNKENNNTNDSPVRRCSWDKPESPQRSSMDNGSPTALPGSKTNSPRNSIHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEALEKAQTTPNGSLQARRTSSLKGSGTKMGTHSVQNGTVRMGILNSDTLGNPGNGRSMSWLPNGYVTLRDNKQKEQAGESGQHNRLSTYDNVHQQFSAMSLDDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPADYENKSDRRSVGGRSSRATSSSDNSETFVSNNTSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 654, "header": "tr|F1MHI2-1|F1MHI2_BOVIN Computationally mapped isoform of Rho GTPase activating protein 24 OS=Bos taurus OX=9913 GN=ARHGAP24 PE=4 SV=3 CANONICAL=A0AAA9SAI9-1" }, "locus": { "chromosome": "6", "start_pos": 100886779, "end_pos": 100814644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005165.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005165.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005165.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005165.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IRU6-1", "protein_name": "Rho GTPase-activating protein 24", "gene_name": "arhgap24", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEQASSAGSSPQHGRGSAKLEVLRCGWLRKQGGFVKTWHTRWFVLRGDQLYYYKDEDETKALGTIFLPGNRVTEHPSNGEEGGKFLFEVIPGGDRERMTSNHETYLLMASTQNDMEDWVKSIRRVIWAPFGGGIFGQKLEETVRYERRYGNKMAPMLVEQCVDFIRNWGLREEGLFRLPGQANLVKELQDAFDCGEKPSFDCNTDVHTVASLLKLYLRELPEPVIPFSKYEEFLACTKLLSKDQEAGMKELRRQVEALPVVNYNLLKYICKFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPVTIMEGTVLVQQLMAVLIGQHDVLFPAEEEHSSTLELVNNNNNETQKQPTNGQLQNKENNNTTGARQCTWDAPESPNRTPLDNGSPRSGSPRNGFTGQKFEVTRSPPLAVKKNPAFSKGSGIVTNGSFSSSSSSSGDASQDKTQTLPNMGTLHARRTGAIKGSGTKMGVQNGVVRMGVSSTDVTNGTINARNGLWVPNGHVTMRDGKSREPEHQQNRLSTYDNVQIHQQQMTQPSLSSSCEDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFFGSNFEDPLLDGPVQEENRLALEDREQRTSNGGGRGSRGTSNSSENSDTFPVTNGPTNHSALHSLVSSLKQEMLKQKNEYEARIKSLEHRNLELEAVMANLHEELDQEKKKYTMVEIKLRNAERAKDDAEKRNEMLQKEMEQFFSTFGDLTADPRRPDRANTIWIQ", "length": 752 }, "evidence": [ { "id": "A0AAA9SAI9", "url": "https://omabrowser.org/oma/group/A0AAA9SAI9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XM50-1", "protein_name": "Rho GTPase-activating protein 24", "gene_name": "ARHGAP24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYFTSHCPACLSASMSVIFPFKLLFSPYCLHPRNICGMFRILFLAVTASVQPNAHLHSSALNAFQAVSVSSGEKSNTQSKLLIGELLRSSMDEHNGSAEMPSVSQGRHGTIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDEIKPLGAIFLPGNRVIEHPCNEESPGKFLFEVVPGGDRERMTANHETYLLMASTQNDMEDWVKSIRRVIWAPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYDDFLSCAKMLSKEEEMGLIELVKQVKSLPAVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHEELFPKDADPEVGPEVCNNNNEMPKKAIVGQLQNKENNNTKETAVRRCSWDKPESPQRGSMDNESPTALPGSKTSSPRNSVQKLDVTRSPPLMVKKNPAFNKGSGIVTNGSFSSSVESHEKSQTLPTCTMQARRTSSLKGAVTKMGTQSMQNGGVRMGVSSTDGLTNTLSNRSPGWAPNGSVTLRDNKQKESVSESGQHNRLSTYDNVHQQFSTVNSDDKQSVDSATWSTSSCEISLPEHSNSCRSSTTTCPEQDFFAGNFEDSVLDGPPQEDLSNTGDYENKSDRRSVGGHSSRATSSSDNSETFVANSTNNHSALHSLVSSLKQEMAKQKLEYETRIKSLEQRNLTLETEMIALHEELDQERKKFTMVEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRPERGNTIWIQ", "length": 836 }, "evidence": [ { "id": "A0AAA9SAI9", "url": "https://omabrowser.org/oma/group/A0AAA9SAI9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RW15-1", "protein_name": "Rho GTPase-activating protein 24", "gene_name": "ARHGAP24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEENHDSTENPQQSQGQNKAMKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNRVLEHPCNEESPGKFLFEVVPGGNRERMTANHESYLLMASTQNDMEDWVRSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPAVNYNLLKYICRFLDEVQSYSGINKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDHLFPKDAELQSKPQDGVSSNNNDLQKKATMGQLQNKENTTTKDSPGRRCSWDKSESPQRSSVDNGSPTAPSGSKTNSPRNSLHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSHAEGLEKAQSTPNGSLQARRTSSLKGSGTKMGTHSVQNGTVRLGLLNTDALGNPANGRSMSWLPNGYVTLRDNKQKEQAGESGQHNRLSTYDNVHQQFSAGSLDDKQSVDSATWSTSSCEISLPENSTSCRSSTTTCPEQDFYGGTFEDPVLDGPPQDDLAQPGDYENKSDRRSVGGRSSRATSSSDNSETFVANNTSTHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 749 }, "evidence": [ { "id": "A0AAA9SAI9", "url": "https://omabrowser.org/oma/group/A0AAA9SAI9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5U2Z7-1", "protein_name": "Rho GTPase-activating protein 24", "gene_name": "Arhgap24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEENCDSTENPHSQGRQNATKCGWLRKQGGFVKTWHTRWFVLKGDQLHYFKDEDETKPLGTIFLPGNKVIEHPCNEESPGKFLFEVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELTKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQSKPQEGPNSNNNDGHKKVTMGQLQNKENNNTKESPVRRCSWDKPESPQRSSMDNGSPTALSGSKTNSPRNSIHKLDVSRSPPLTVKKNPAFNKGSGIVTNGSFSSSNAEGVEKTQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSLMNLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLNLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ", "length": 748 }, "evidence": [ { "id": "A0AAA9SAI9", "url": "https://omabrowser.org/oma/group/A0AAA9SAI9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C4V1-1", "protein_name": "Rho GTPase-activating protein 24", "gene_name": "Arhgap24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEERCESTESPQGQGRKNTKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLHGNKVIEHPCNEENPGKFLFDVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELMKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQSKPQDGPNSNNNDGHKKATMGQLQNKENNNTKESPVRRCSWDKPESPQRSSVDNGSPTALSGSKTNSPRNSIHKLDISRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGVEKPQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSSMSLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYVGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ", "length": 747 }, "evidence": [ { "id": "A0AAA9SAI9", "url": "https://omabrowser.org/oma/group/A0AAA9SAI9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N264-1", "protein_name": "Rho GTPase-activating protein 24", "gene_name": "ARHGAP24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ", "length": 748 }, "evidence": [ { "id": "A0AAA9SAI9", "url": "https://omabrowser.org/oma/group/A0AAA9SAI9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "anchoring junction", "id": "GO:0070161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "negative regulation of ruffle assembly", "id": "GO:1900028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900028", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "wound healing, spreading of epidermal cells", "id": "GO:0035313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035313", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" }, { "name": "negative regulation of Rac protein signal transduction", "id": "GO:0035021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" }, { "start_pos": 695, "end_pos": 697, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 73, "end_pos": 179, "start_aa": "Asn", "end_aa": "Trp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI9" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 383, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 419, "end_pos": 421 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 444, "end_pos": 446 }, { "start_pos": 490, "end_pos": 492 }, { "start_pos": 509, "end_pos": 511 }, { "start_pos": 534, "end_pos": 536 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 622, "end_pos": 624 }, { "start_pos": 664, "end_pos": 666 }, { "start_pos": 691, "end_pos": 693 }, { "start_pos": 692, "end_pos": 694 }, { "start_pos": 695, "end_pos": 697 }, { "start_pos": 728, "end_pos": 730 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAL0-1", "uniprot_ac": "A0AAA9SAL0", "uniprot_id": "A0AAA9SAL0_BOVIN", "mass": { "chemical_mass": 43430.0, "monoisotopic_mass": 43430.0 }, "refseq": { "ac": "NP_001025017", "name": "2',5'-oligoadenylate synthetase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" }, "gene_names": [ { "name": "OAS1Z", "type": "recommended", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ] }, { "name": "OAS1Z", "type": "synonym", "evidence": [ { "id": "NP_001025017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" } ] }, { "name": "OAS1", "type": "synonym", "evidence": [ { "id": "NP_001025017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" } ] } ], "protein_names": [ { "name": "2'-5' oligoadenylate synthase", "type": "recommended", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0/entry#names_and_taxonomy" } ] }, { "name": "2',5'-oligoadenylate synthetase 1", "type": "synonym", "evidence": [ { "id": "NP_001025017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" } ] }, { "name": "2'-5' oligoadenylate synthetase 1z", "type": "synonym", "evidence": [ { "id": "NP_001025017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" } ] }, { "name": "2.7.7.84", "type": "synonym", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Data indicate that the expression profiles of ISG15, MX1, MX2, and OAS1 could be a useful diagnostic biomarker of gestation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001025017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" }, { "database": "PubMed", "id": "23384108", "url": "https://glygen.org/publication/PubMed/23384108" } ] }, { "annotation": "Polymorphisms in OAS1 gene in cattle are associated with reproductive traits and it can be chosen as a candidate gene for improvement of reproductive performance of cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_001025017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" }, { "database": "PubMed", "id": "29277982", "url": "https://glygen.org/publication/PubMed/29277982" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OAS1Z", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0", "locus": { "chromosome": "17", "start_pos": 61391707, "end_pos": 61402685, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063501", "url": "https://www.ensembl.org/id/ENSBTAG00000063501" } ] } } ], "crossref": [ { "id": "A0AAA9SAL0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAL0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519922", "url": "https://www.ncbi.nlm.nih.gov/gene/519922", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519922", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519922", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11258:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11258:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001025017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "34407", "url": "https://www.rhea-db.org/rhea/34407", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKLRKTQANKLDKFIKDHLLPHEEFQRQVNEAIDIICTFLKETCFQESTHPVRVSKVVKGGSSGKGTTLKDLSDADLVVFLTNLTSFQENFEHRVRFIKEIRRQLEAYQRQKTFEVEFEVLKQRKRKRRALSFVLRSPWFCQGVKFDVLPAFDALAKYSQSQAQVTEDYKPNPQIYVQLIQECENLRREGEFSPCFTELQRAFLKERPAKLKSLIRLVKHWYQQCKKRHGKKLPSQYALELLTIYAWEQEGSKTKFRTAEGFRTVLELVLKHQDLCIYWKKYYDFENPIITQCLKRQLEKPRPVILDPADPTGNVAGREPQRWQLLAQEVTVWLKYSCCKNRNGSPVSPWNVPVTPPHYLSDLILMAC", "length": 369, "header": "tr|A0AAA9SAL0-1|A0AAA9SAL0_BOVIN Isoform 1 of 2'-5' oligoadenylate synthase OS=Bos taurus OX=9913 GN=OAS1Z PE=3 SV=1 CANONICAL=A0AAA9SAL0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0/entry#A0AAA9SAL0-1", "sequence": { "sequence": "MKKLRKTQANKLDKFIKDHLLPHEEFQRQVNEAIDIICTFLKETCFQESTHPVRVSKVVKGGSSGKGTTLKDLSDADLVVFLTNLTSFQENFEHRVRFIKEIRRQLEAYQRQKTFEVEFEVLKQRKRKRRALSFVLRSPWFCQGVKFDVLPAFDALAKYSQSQAQVTEDYKPNPQIYVQLIQECENLRREGEFSPCFTELQRAFLKERPAKLKSLIRLVKHWYQQCKKRHGKKLPSQYALELLTIYAWEQEGSKTKFRTAEGFRTVLELVLKHQDLCIYWKKYYDFENPIITQCLKRQLEKPRPVILDPADPTGNVAGREPQRWQLLAQEVTVWLKYSCCKNRNGSPVSPWNVPVTPPHYLSDLILMAC", "length": 369, "header": "tr|A0AAA9SAL0-1|A0AAA9SAL0_BOVIN Isoform 1 of 2'-5' oligoadenylate synthase OS=Bos taurus OX=9913 GN=OAS1Z PE=3 SV=1 CANONICAL=A0AAA9SAL0-1" }, "locus": { "chromosome": "17", "start_pos": 61402579, "end_pos": 61395240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082376.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 356, "start_aa": "Thr", "end_pos": 356, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr356", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Differential neutrophil gene expression in early bovine pregnancy.", "journal": "Reproductive biology and endocrinology : RB&E", "date": "2013-02-05", "authors": "Kizaki Keiichiro, Shichijo-Kizaki Ayumi, Furusawa Tadashi, Takahashi Toru, Hosoe Misa, Hashizume Kazuyoshi", "evidence": [ { "database": "RefSeq", "id": "NP_001025017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" } ], "reference": [ { "type": "PubMed", "id": "23384108", "url": "https://glygen.org/publication/PubMed/23384108" } ] }, { "title": "Association analysis of novel polymorphisms in 2', 5'-oligoadenylate synthetase gene with reproductive traits in indigenous and cross-bred cattle of Indian Origin.", "journal": "Reproduction in domestic animals = Zuchthygiene", "date": "2018-04", "authors": "Alex R, Ramesha K P, Singh U, Kumar S, Alyethodi R R, Deb R, Rai S, Sharma S, Sengar G S, Kumar A, Prakash B", "evidence": [ { "database": "RefSeq", "id": "NP_001025017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025017" } ], "reference": [ { "type": "PubMed", "id": "29277982", "url": "https://glygen.org/publication/PubMed/29277982" } ] } ], "pathway": [ { "id": "bta:519922", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519922", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ], "pmid": "" }, { "name": "2'-5'-oligoadenylate synthetase activity", "id": "GO:0001730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "34407", "name": "", "equation": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SAL0-1", "F1N009-1", "F1MV66-1", "F1N3B8-1" ], "evidence": [ { "id": "34407", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34407" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SAL0", "gene_name": "OAS1Z", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" } ] } ] }, { "uniprot_ac": "F1MV66", "gene_name": "OAS1Y", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "F1MV66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV66" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "F1MV66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV66" } ] } ] }, { "uniprot_ac": "F1N009", "gene_name": "OAS1X", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "F1N009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N009" } ] } ] }, { "uniprot_ac": "F1N3B8", "gene_name": "OAS2", "activity": [ { "ec_number": "2.7.7.84", "activity": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "F1N3B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B8" } ] }, { "ec_number": "2.7.7.84", "activity": "", "evidence": [ { "id": "F1N3B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3B8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" }, { "id": "PF10421", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10421" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "2'-5'-oligoadenylate synthetase 1", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 355, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAL0" }, { "id": "PF01909", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01909" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Polymerase nucleotidyl transferase", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 106, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.84", "ec_name": "3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate.", "evidence": [ { "id": "2.7.7.84", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84" }, { "id": "2.7.7.84", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.84" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 356 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 344, "end_pos": 346 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SAM7-1", "uniprot_ac": "A0AAA9SAM7", "uniprot_id": "A0AAA9SAM7_BOVIN", "mass": { "chemical_mass": 149081.0, "monoisotopic_mass": 149081.0 }, "refseq": {}, "gene_names": [ { "name": "DENND5A", "type": "recommended", "evidence": [ { "id": "A0AAA9SAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ] } ], "protein_names": [ { "name": "DENN domain containing 5A", "type": "synonym", "evidence": [ { "id": "A0AAA9SAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENND5A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7", "locus": { "chromosome": "15", "start_pos": 43469479, "end_pos": 43375016, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006322", "url": "https://www.ensembl.org/id/ENSBTAG00000006322" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006322", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006322", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01757", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01757", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17690", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17690", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17692", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17692", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784484", "url": "https://www.ncbi.nlm.nih.gov/gene/784484", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784484", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784484", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQPYLHA", "url": "https://omabrowser.org/oma/group/QQPYLHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUN3", "url": "https://www.orthodb.org/?gene=A0A3Q1MUN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N6W4", "url": "https://www.orthodb.org/?gene=F1N6W4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46070:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46070:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MUN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6W4", "url": "https://www.uniprot.org/uniprotkb/F1N6W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6W4-1", "url": "https://www.uniprot.org/uniprotkb/F1N6W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGGGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASSFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADSRDLSGMEDGDGTPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIVCQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGSLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYEFLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAKKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGIFLDSERRKSDASSVMSPLKISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNLLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNRPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNELVPEENWHMRARNFCRFVTAINNNPRNIGKDGKFQMLVCLGARVVMKVSLTKGPAHARCYLDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI", "length": 1308, "header": "tr|A0AAA9SAM7-1|A0AAA9SAM7_BOVIN Isoform 1 of DENN domain containing 5A OS=Bos taurus OX=9913 GN=DENND5A PE=3 SV=2 CANONICAL=A0AAA9SAM7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7/entry#A0A3Q1MUN3-1", "sequence": { "sequence": "MLNLVGETVFLTEEHLLHTPLGREDHIEALCQYIQASKARDGASSFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADSRDLSGMEDGDGTPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIVCQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGSLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYEFLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAKKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGIFLDSERRKSDASSVMSPLKISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNLLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNRPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNELVPEENWHMRARNFCRFVTAINNNPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI", "length": 1279, "header": "tr|A0A3Q1MUN3-1|A0A3Q1MUN3_BOVIN Computationally mapped isoform of DENN domain containing 5A OS=Bos taurus OX=9913 GN=DENND5A PE=3 SV=2 CANONICAL=A0AAA9SAM7-1" }, "locus": { "chromosome": "15", "start_pos": 43468475, "end_pos": 43380807, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069720.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069720.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074326.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074326.2" } ] } }, { "isoform_ac": "A0AAA9SAM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7/entry#A0AAA9SAM7-1", "sequence": { "sequence": "MSGGGGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASSFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADSRDLSGMEDGDGTPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIVCQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGSLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYEFLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAKKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGIFLDSERRKSDASSVMSPLKISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNLLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNRPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNELVPEENWHMRARNFCRFVTAINNNPRNIGKDGKFQMLVCLGARVVMKVSLTKGPAHARCYLDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI", "length": 1308, "header": "tr|A0AAA9SAM7-1|A0AAA9SAM7_BOVIN Isoform 1 of DENN domain containing 5A OS=Bos taurus OX=9913 GN=DENND5A PE=3 SV=2 CANONICAL=A0AAA9SAM7-1" }, "locus": { "chromosome": "15", "start_pos": 43468475, "end_pos": 43375215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103286.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103286.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080504.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080504.2" } ] } }, { "isoform_ac": "A0AAA9T7N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7/entry#A0AAA9T7N9-1", "sequence": { "sequence": "MSGGGGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASSFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADSRDLSGMEDGDGTPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIVCQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGSLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYEFLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAKKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGIFLDSERRKSDASSVMSPLKISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNLLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNRPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNELVPEENWHMRARNFCRFVTAINNNPRNIGKDGKFQMLVCLGARYCSPVAQRAGSQPCRNPGEVPGVGSIL", "length": 1257, "header": "tr|A0AAA9T7N9-1|A0AAA9T7N9_BOVIN Computationally mapped isoform of DENN domain containing 5A OS=Bos taurus OX=9913 GN=DENND5A PE=3 SV=2 CANONICAL=A0AAA9SAM7-1" }, "locus": { "chromosome": "15", "start_pos": 43466615, "end_pos": 43375215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124608.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124608.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092611.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092611.2" } ] } }, { "isoform_ac": "F1N6W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7/entry#F1N6W4-1", "sequence": { "sequence": "MSGGGGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADSRDLSGMEDGDGTPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIVCQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGSLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYEFLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAKKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGIFLDSERRKSDASSVMSPLKISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNLLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNRPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNELVPEENWHMRARNFCRFVTAINNNPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI", "length": 1266, "header": "tr|F1N6W4-1|F1N6W4_BOVIN Computationally mapped isoform of DENN domain containing 5A OS=Bos taurus OX=9913 GN=DENND5A PE=3 SV=3 CANONICAL=A0AAA9SAM7-1" }, "locus": { "chromosome": "15", "start_pos": 43468475, "end_pos": 43375215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008297.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008297.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008297.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008297.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784484", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784484", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RT22-1", "protein_name": "DENN domain containing 5A", "gene_name": "DENND5A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGGSGGGSSAPGRFADYFVICGLDTETGLEPDELSALCQYIQASKTRDGASRFISSATEGENFDQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADSREPQFHSFIITREDGSRTFGFSLTFFEEVTSKQICSAMQTLYHMHNAEYDILHTPPTNDKDSCSSTGDCNGTSISKLQRFNSYDISRDTLYVSKCICLITPMSFMKACKKVLEQLHQAVTSPQPPPLPLESYIYNILYEVPLPPAGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVVQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEISEILTAFGIPPEGNLHYSESASKMKSLRACDLVSDKRNGNVAGSPLNSYELLKENETIARLQALVKRTGVSLEKLEVREETSSKKDLKIQCDEEEFKIYQLNIQIREIFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDEDDKDPILRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTIDEAEKSIELRLAKIDHTAVHPHLLDMKIGQGKYELGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNLGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQIKQDRSCTAFVLEDRASVYSASTQIWAFQTTRRPTLHKGKSALWSHLLHYLENRQRKTTSGSFSTSGILLDSERRKSDTSPGMSPLRISLVQDMRHIQNISEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETGVLQIPRNILEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSNTEADERQCRTPPLQQSPSMIRRLVTISPNNKPKLNTGQIQEAIGEAVNGIVKHFHKPEKERGSLTLLLCGESGLVSALEQVFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNEMVPEENWQTRARNFCRFITAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAQMYEDIALIKDHTLVNSLIRVLQTLQEFNITLEASLVKGIDI", "length": 1323 }, "evidence": [ { "id": "A0AAA9SAM7", "url": "https://omabrowser.org/oma/group/A0AAA9SAM7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8M3B1L1-1", "protein_name": "DENN domain-containing protein 5A isoform X1", "gene_name": "dennd5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTGFSSSSCRFADYFVICGLDTESGLEPDELSALCQYIQATKFTDGARGKLASANEGENFEQSPLRRTFKSKVLAHYPDNVEWNPFDQDAVGMLCMPKGLSFRTQTDTREPQFHSFIITREDGSRTYGFALTFFEEVTSKQICSAMQTLYHMHNAEQYDILHTPPTPRSPEDPRPTTQQLHASPALSRLQRFNSYDISRDTLYVSKCICLITPMAFAHACRKVLEQLHQAVTSPQPPPLPLESYVYNVLYEVPLPPAGRSLKFSGVYRPVICQRPSTAELPLFDFPLQEVFELLGLENILQLFTCALLEIQILLYSQHYQRLMTVAESITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGQDDRTKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFIQEISEVLLAFGLSPEANPQCSEGQSKIRGFRCGDMASDKRNGNLAGSPLNSFLLRENQTIARLQALVKRTGVSLEKLDVKDDASTNKDTKVQCEEEEMKMHQLNIRVREVFANRFSQMFSDYEVFVIQPSQDKESWFSNRDQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDSKILCHDDEDKEHTLRVFDSRVDKIRMINVRTPTLRTSMYQKCTNIDEAEKAIEVRLCKIDHTALHPHLLDMKIGQGRYEPGFFPRLQSDVLSTGPTSNKWAKRSAPAQWRRKDRQKQHAEHLYLDNDQREHVECLFSELQLLLALDYYWFSQSFRPCLKSVKVDVKYIQEARNLGTTLRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVSITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQESKEKRDATPAGLGPPGIIHDTERRKSDASCAMPPLKVSLIQDMRHIQNISEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTIMIPYHVVIIPSKKLGGSMFTANPWVCVSGELAETGVLQVPKNTLEITFECQNLGKLTTVQMGHDNSGLYAKWLVECVMVRNGITGHTYKFPCGRWLGKGVDDGSLERILVGELVTNMESDERMCRTPPMQQSPGMMRRFVTISPNSKPKLNTGQIQESVGEAINGIVKHFHKPEKERGSLTLLLCGEYGLVWALEQVFQHGFKSPRLFKNVFIWDFLEKAQVYFESAERSQMTQDENWQMRVRHFCHFMRAINSTPRNIGKDGKFQMLVCLGARDHLLHHWIALLAECPITAQMYEDVALLKDHSLVNSLIRVLQTLQEFNITLEASLVKGIGI", "length": 1323 }, "evidence": [ { "id": "A0AAA9SAM7", "url": "https://omabrowser.org/oma/group/A0AAA9SAM7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3V7Q0-1", "protein_name": "DENN domain-containing protein 5A", "gene_name": "Dennd5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKKNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWLSNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAVMSPLRVSLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTSLVKGIDI", "length": 1287 }, "evidence": [ { "id": "A0AAA9SAM7", "url": "https://omabrowser.org/oma/group/A0AAA9SAM7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6IQ26-1", "protein_name": "DENN domain-containing protein 5A", "gene_name": "DENND5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI", "length": 1287 }, "evidence": [ { "id": "A0AAA9SAM7", "url": "https://omabrowser.org/oma/group/A0AAA9SAM7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PAL8-1", "protein_name": "DENN domain-containing protein 5A", "gene_name": "Dennd5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAVMSPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVECVMVRNEVTGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTSLVKGIDI", "length": 1287 }, "evidence": [ { "id": "A0AAA9SAM7", "url": "https://omabrowser.org/oma/group/A0AAA9SAM7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W0E1-1", "protein_name": "Pinstripe, isoform A", "gene_name": "pns", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTTRENVVSSRLSKLMLSSGSGNGSGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDTGLEPDRFAGDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIRVYLPPTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATSYEPCVLSQDSQQGFEKRLNCIDIEVTPPSEILANRAAYFRSFPLLEKGVLNQECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANLTTADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSVQRQETLAPSEIQHQLGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREISSIWRLYVQLMDEINGTALGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSITQGIRIASQC", "length": 1449 }, "evidence": [ { "id": "A0AAA9SAM7", "url": "https://omabrowser.org/oma/group/A0AAA9SAM7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1295, "end_pos": 1297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" }, { "start_pos": 740, "end_pos": 742, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 786, "end_pos": 788, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" }, { "id": "PS50095", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50095" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PLAT", "eco_id": "ECO_0000259", "start_pos": 957, "end_pos": 1065, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" }, { "id": "PS50826", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50826" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RUN", "eco_id": "ECO_0000259", "start_pos": 790, "end_pos": 953, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM7" }, { "id": "PS50211", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UDENN", "eco_id": "ECO_0000259", "start_pos": 60, "end_pos": 601, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1295, "end_pos": 1297 }, { "start_pos": 469, "end_pos": 471 }, { "start_pos": 740, "end_pos": 742 }, { "start_pos": 763, "end_pos": 765 }, { "start_pos": 786, "end_pos": 788 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAP3-1", "uniprot_ac": "A0AAA9SAP3", "uniprot_id": "A0AAA9SAP3_BOVIN", "mass": { "chemical_mass": 28586.0, "monoisotopic_mass": 28586.0 }, "refseq": { "ac": "XP_005228331", "name": "spindlin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228331" }, "gene_names": [ { "name": "SPIN4", "type": "recommended", "evidence": [ { "id": "A0AAA9SAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3" } ] }, { "name": "SPIN4", "type": "synonym", "evidence": [ { "id": "XP_005228331", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228331" } ] } ], "protein_names": [ { "name": "Spindlin family member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3/entry#names_and_taxonomy" } ] }, { "name": "spindlin-4", "type": "synonym", "evidence": [ { "id": "XP_005228331", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228331" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPIN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3", "locus": { "chromosome": "X", "start_pos": 96827202, "end_pos": 96823951, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057744", "url": "https://www.ensembl.org/id/ENSBTAG00000057744" } ] } } ], "crossref": [ { "id": "A0AAA9SAP3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "540146", "url": "https://www.ncbi.nlm.nih.gov/gene/540146", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540146", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540146", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HGKKDEW", "url": "https://omabrowser.org/oma/group/HGKKDEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02513", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02513", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228331", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228331", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPPTVPPMGVDGVSAYLMKKRHTHRKQRRKPTFLTRRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILPERVPTPRIDSRLADSLIGKAVGHVFEGEHGTKDEWKGMVLARAPVMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSNYYFPAAEREPGEVVDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP", "length": 249, "header": "tr|A0AAA9SAP3-1|A0AAA9SAP3_BOVIN Isoform 1 of Spindlin family member 4 OS=Bos taurus OX=9913 GN=SPIN4 PE=3 SV=1 CANONICAL=A0AAA9SAP3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3/entry#A0AAA9SAP3-1", "sequence": { "sequence": "MSPPTVPPMGVDGVSAYLMKKRHTHRKQRRKPTFLTRRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILPERVPTPRIDSRLADSLIGKAVGHVFEGEHGTKDEWKGMVLARAPVMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSNYYFPAAEREPGEVVDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP", "length": 249, "header": "tr|A0AAA9SAP3-1|A0AAA9SAP3_BOVIN Isoform 1 of Spindlin family member 4 OS=Bos taurus OX=9913 GN=SPIN4 PE=3 SV=1 CANONICAL=A0AAA9SAP3-1" }, "locus": { "chromosome": "X", "start_pos": 96825374, "end_pos": 96824628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103792.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103792.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082412.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082412.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540146", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540146", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZPC2-1", "protein_name": "Spindlin family member 4", "gene_name": "SPIN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPPTVPPMGVDGVSAYLMKKRHTHRKQRRKPAFLTGRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILPERVPTPRIDSRLADSLIGKAVGHVFEGEHGTKDEWKGMVLARAPVMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSSYYFPAAEREPGEAVDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKSS", "length": 249 }, "evidence": [ { "id": "A0AAA9SAP3", "url": "https://omabrowser.org/oma/group/A0AAA9SAP3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I9Q8-1", "protein_name": "Spindlin-4", "gene_name": "LOC100767892", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSPPTVPPTGVDGVSAYLMKKRHTHKKQRRKPTFLTHRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEVLPERVPSPRVDSRLADSLVGKAVGHVFEGEHGKKDEWKGMVLARAPIMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSNYYFPTAEQEPGEVLDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP", "length": 249 }, "evidence": [ { "id": "A0AAA9SAP3", "url": "https://omabrowser.org/oma/group/A0AAA9SAP3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q56A73-1", "protein_name": "Spindlin-4", "gene_name": "SPIN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPPTVPPMGVDGVSAYLMKKRHTHRKQRRKPTFLTRRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILPERVPTPRIDSRLADSLIGKAVEHVFEGEHGTKDEWKGMVLARAPVMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSNYYFPTAEQEPGEVVDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP", "length": 249 }, "evidence": [ { "id": "A0AAA9SAP3", "url": "https://omabrowser.org/oma/group/A0AAA9SAP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K1L2-1", "protein_name": "Spindlin-4", "gene_name": "Spin4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPPTVPPTGVDGVSAYLMKKRHTHKKQRRKPTFLTHRNIVGCRIQHGWKEGNEPVEQWKGTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILPERVPSPRIDSRLADSLVGKAVGHVFEGEHGKKDEWKGMVLARAPIMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIPDSNYYFPAAEQEPGEVLDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHIYVYGLVKTP", "length": 249 }, "evidence": [ { "id": "A0AAA9SAP3", "url": "https://omabrowser.org/oma/group/A0AAA9SAP3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "gamete generation", "id": "GO:0007276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAP4-1", "uniprot_ac": "A0AAA9SAP4", "uniprot_id": "A0AAA9SAP4_BOVIN", "mass": { "chemical_mass": 25712.0, "monoisotopic_mass": 25712.0 }, "refseq": { "ac": "XP_002696114", "name": "B-cell antigen receptor complex-associated protein beta chain isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696114" }, "gene_names": [ { "name": "CD79B", "type": "recommended", "evidence": [ { "id": "A0AAA9SAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ] }, { "name": "CD79B", "type": "synonym", "evidence": [ { "id": "XP_002696114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696114" } ] } ], "protein_names": [ { "name": "B-cell antigen receptor complex-associated protein beta chain", "type": "recommended", "evidence": [ { "id": "A0AAA9SAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#names_and_taxonomy" } ] }, { "name": "B-cell antigen receptor complex-associated protein beta chain isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002696114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696114" } ] }, { "name": "B-cell-specific glycoprotein B29", "type": "synonym", "evidence": [ { "id": "A0AAA9SAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#names_and_taxonomy" } ] }, { "name": "Ig-beta", "type": "synonym", "evidence": [ { "id": "A0AAA9SAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#names_and_taxonomy" } ] }, { "name": "Immunoglobulin-associated B29 protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4#function" }, { "database": "UniProtKB", "id": "ARBA00056166", "url": "https://www.uniprot.org/uniprotkb/ARBA00056166#function" }, { "database": "UniProtKB", "id": "A0AAA9SE00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE00#function" }, { "database": "UniProtKB", "id": "F1MMQ7", "url": "https://www.uniprot.org/uniprotkb/F1MMQ7#function" }, { "database": "UniProtKB", "id": "A0AAA9SZW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZW2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD79B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4", "locus": { "chromosome": "19", "start_pos": 48131531, "end_pos": 48136252, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044204", "url": "https://www.ensembl.org/id/ENSBTAG00000044204" } ] } } ], "crossref": [ { "id": "A0AAA9SAP4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044204", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044204", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509801", "url": "https://www.ncbi.nlm.nih.gov/gene/509801", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509801", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509801", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PVHFICY", "url": "https://omabrowser.org/oma/group/PVHFICY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMQ7", "url": "https://www.orthodb.org/?gene=F1MMQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14334:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14334:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5690714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5690714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002696114", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696114", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0C1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0C1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMQ7", "url": "https://www.uniprot.org/uniprotkb/F1MMQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMQ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSALIPGLNNWLVLGLLLLSGEKVLADKTDDLLRDPKGNTCSRIWQHPRFVAKKRGSTVEIRCHVEDDGLVSWFRKPKPDSEPKTLHAEQGRILQSHNKSEAVLTILSVQFQDNGIYFCKQECAKGTQRTEHGCGTELRVMGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 229, "header": "tr|A0AAA9SAP4-1|A0AAA9SAP4_BOVIN Isoform 1 of B-cell antigen receptor complex-associated protein beta chain OS=Bos taurus OX=9913 GN=CD79B PE=4 SV=1 CANONICAL=A0AAA9SAP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#A0AAA9SAP4-1", "sequence": { "sequence": "MAGSALIPGLNNWLVLGLLLLSGEKVLADKTDDLLRDPKGNTCSRIWQHPRFVAKKRGSTVEIRCHVEDDGLVSWFRKPKPDSEPKTLHAEQGRILQSHNKSEAVLTILSVQFQDNGIYFCKQECAKGTQRTEHGCGTELRVMGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 229, "header": "tr|A0AAA9SAP4-1|A0AAA9SAP4_BOVIN Isoform 1 of B-cell antigen receptor complex-associated protein beta chain OS=Bos taurus OX=9913 GN=CD79B PE=4 SV=1 CANONICAL=A0AAA9SAP4-1" }, "locus": { "chromosome": "19", "start_pos": 48135436, "end_pos": 48132535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110685.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110685.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079240.1" } ] } }, { "isoform_ac": "A0AAA9SE00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#A0AAA9SE00-1", "sequence": { "sequence": "MATCTLAKRLGSGSIAVPPALLPRPSWMSGEKVLADKTDDLLRDPKGNTCSRIWQHPRFVAKKRGSTVEIRCHVEDDGLVSWFRKPKPDSEPKTLHAEQGRILQSHNKSEAVLTILSVQFQDNGIYFCKQECAKGTQRTEHGCGTELRVMGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 236, "header": "tr|A0AAA9SE00-1|A0AAA9SE00_BOVIN Computationally mapped isoform of B-cell antigen receptor complex-associated protein beta chain OS=Bos taurus OX=9913 GN=CD79B PE=4 SV=1 CANONICAL=A0AAA9SAP4-1" }, "locus": { "chromosome": "19", "start_pos": 48135969, "end_pos": 48132535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112541.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112541.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084361.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084361.1" } ] } }, { "isoform_ac": "A0AAA9SZW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#A0AAA9SZW2-1", "sequence": { "sequence": "MAGSALIPGLNNWLVLGLLLLSAGEKVLADKTDDLLRDPKGNTCSRIWQHPRFVAKKRGSTVEIRCHVEDDGLVSWFRKPKPDSEPKTLHAEQGRILQSHNKSEAVLTILSVQFQDNGIYFCKQECAKGTQRTEHGCGTELRVMGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 230, "header": "tr|A0AAA9SZW2-1|A0AAA9SZW2_BOVIN Computationally mapped isoform of B-cell antigen receptor complex-associated protein beta chain OS=Bos taurus OX=9913 GN=CD79B PE=4 SV=1 CANONICAL=A0AAA9SAP4-1" }, "locus": { "chromosome": "19", "start_pos": 48135436, "end_pos": 48132535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101786.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101786.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089662.1" } ] } }, { "isoform_ac": "A0AAA9T0C1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#A0AAA9T0C1-1", "sequence": { "sequence": "MAGSALIPGLNNWLVLGLLLLSGEKVLADKTDDLLRDPKGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 125, "header": "tr|A0AAA9T0C1-1|A0AAA9T0C1_BOVIN Computationally mapped isoform of CD79b molecule OS=Bos taurus OX=9913 GN=CD79B PE=4 SV=1 CANONICAL=A0AAA9SAP4-1" }, "locus": { "chromosome": "19", "start_pos": 48135436, "end_pos": 48132535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132150.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132150.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091143.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091143.1" } ] } }, { "isoform_ac": "F1MMQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4/entry#F1MMQ7-1", "sequence": { "sequence": "MAGSALIPGLNNWLVLGLLLLSGNTCSRIWQHPRFVAKKRGSTVEIRCHVEDDGLVSWFRKPKPDSEPKTLHAEQGRILQSHNKSEAVLTILSVQFQDNGIYFCKQECAKGTQRTEHGCGTELRVMGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 212, "header": "tr|F1MMQ7-1|F1MMQ7_BOVIN Computationally mapped isoform of B-cell antigen receptor complex-associated protein beta chain OS=Bos taurus OX=9913 GN=CD79B PE=4 SV=3 CANONICAL=A0AAA9SAP4-1" }, "locus": { "chromosome": "19", "start_pos": 48135436, "end_pos": 48132535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061488.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061488.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053195.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053195.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509801", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509801", "resource": "KEGG Pathway" }, { "id": "R-BTA-5690714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5690714", "resource": "Reactome", "description": "CD22 mediated BCR regulation" }, { "id": "R-BTA-983695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983695", "resource": "Reactome", "description": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4ID76-1", "protein_name": "Uncharacterized protein cd79b isoform X1", "gene_name": "cd79b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVLICMFLRSIFTALDLHLLAEAGLCSGELYSFCSLSVTDVYITFRGGFEDFNIMHHFLLGFSVMALIYLSAEGSIIVFQKPRFIGVKTGRTVIIYCVPSNPTRGPARVQWFKNKNYQSSLTNDQRITINDRNNDKNASITLKKVETEDSGTYVCKLNDTFGPGTALQVSRYSEPHAVLMRSRVKDVIIFLQAFLLVLCIVVPLVRLYKLEKKEEAEYEEPEDDHIYEGLEIEQVGGDVYEDISTFAQSSDAAWQVESPCQE", "length": 263 }, "evidence": [ { "id": "A0AAA9SAP4", "url": "https://omabrowser.org/oma/group/A0AAA9SAP4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A4X1T0R0-1", "protein_name": "B-cell antigen receptor complex-associated protein beta chain", "gene_name": "CD79B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGPALSPGLSNWLVLLLLLLSGETVLEAETKELRDPKGGACSRIWQHPRFVARKRGSMVEIRCYVEDPGIVSWLRKQEADLEPKIFPPEEGRIIQNQTTSEATLIIQGVQFQDNGVYYCKQECSKEPLRTEQGCGTELRVMGFSTLAQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKPGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 228 }, "evidence": [ { "id": "A0AAA9SAP4", "url": "https://omabrowser.org/oma/group/A0AAA9SAP4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8J8XPU7-1", "protein_name": "B-cell antigen receptor complex-associated protein beta chain", "gene_name": "Cd79b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLPSRVPGEMVPPLGLNLHGRKGPNGEEVERRKVAARADTQLHVLPQTLLGLRDRAVTMATLVLSPVPCHWLMFLLLLLSGEPVPAMTKSDQPPIFQGSPCSKIWQHPRFAAKKRSSMVKFHCHTDYSGVMTWFRQKGNQRPQELFPEDGHISQTRNGSVYTLTLQNIQYEDNGIYFCQQKCNSTEPDVTDGCGTELLVLGFSTLDQLKRRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLNIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 287 }, "evidence": [ { "id": "A0AAA9SAP4", "url": "https://omabrowser.org/oma/group/A0AAA9SAP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P15530-1", "protein_name": "B-cell antigen receptor complex-associated protein beta chain", "gene_name": "Cd79b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLVLSSMPCHWLLFLLLLFSGEPVPAMTSSDLPLNFQGSPCSQIWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCDSANHNVTDSCGTELLVLGFSTLDQLKRRNTLKDGIILIQTLLIILFIIVPIFLLLDKDDGKAGMEEDHTYEGLNIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 228 }, "evidence": [ { "id": "A0AAA9SAP4", "url": "https://omabrowser.org/oma/group/A0AAA9SAP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P40259-1", "protein_name": "B-cell antigen receptor complex-associated protein beta chain", "gene_name": "CD79B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE", "length": 229 }, "evidence": [ { "id": "A0AAA9SAP4", "url": "https://omabrowser.org/oma/group/A0AAA9SAP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8AV16-1", "protein_name": "B-cell antigen receptor complex-associated protein beta chain", "gene_name": "CD79B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGDFCRRLWVLQVNLWLMAVAAGGIPTDGNSTSNRTGSECVGMWQHPRYIAAKKNTSVHFICYTSQPHAMQWYKALGNGKEFHVLDQSSDRFSINNTNDRISFTISRISYEDNGIYVCDSKNLTEEKRQPNSCGTEIRVMSRSNIQQIQNRNTLKDTIIIIQTILLVIFISVPMLLFLEKGDRKERPEEDHTYEGLEVEQIATYEDITPFRDMKAKWTVGEHPGEE", "length": 226 }, "evidence": [ { "id": "A0AAA9SAP4", "url": "https://omabrowser.org/oma/group/A0AAA9SAP4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "B cell differentiation", "id": "GO:0030183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "B cell receptor complex", "id": "GO:0019815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "IgM B cell receptor complex", "id": "GO:0071755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071755", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAP4" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 121, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAT5-1", "uniprot_ac": "A0AAA9SAT5", "uniprot_id": "A0AAA9SAT5_BOVIN", "mass": { "chemical_mass": 8941.0, "monoisotopic_mass": 8941.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM238L", "type": "recommended", "evidence": [ { "id": "A0AAA9SAT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5" } ] } ], "protein_names": [ { "name": "Transmembrane protein 238 like", "type": "synonym", "evidence": [ { "id": "A0AAA9SAT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM238L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5", "locus": { "chromosome": "19", "start_pos": 29755720, "end_pos": 29755959, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065177", "url": "https://www.ensembl.org/id/ENSBTAG00000065177" } ] } } ], "crossref": [ { "id": "A0AAA9SAT5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28613", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28613", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28613:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28613:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPGKLWGTCRLGRCALFFGLALLLDVVGLVLLLVGIFASLDFWDFLIYTGSLILAFSLLFWIAWYTLNMEVPLEKLDL", "length": 79, "header": "tr|A0AAA9SAT5-1|A0AAA9SAT5_BOVIN Isoform 1 of Transmembrane protein 238 like OS=Bos taurus OX=9913 GN=TMEM238L PE=4 SV=1 CANONICAL=A0AAA9SAT5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5/entry#A0AAA9SAT5-1", "sequence": { "sequence": "MLPGKLWGTCRLGRCALFFGLALLLDVVGLVLLLVGIFASLDFWDFLIYTGSLILAFSLLFWIAWYTLNMEVPLEKLDL", "length": 79, "header": "tr|A0AAA9SAT5-1|A0AAA9SAT5_BOVIN Isoform 1 of Transmembrane protein 238 like OS=Bos taurus OX=9913 GN=TMEM238L PE=4 SV=1 CANONICAL=A0AAA9SAT5-1" }, "locus": { "chromosome": "19", "start_pos": 29755959, "end_pos": 29755723, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113510.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113510.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083210.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083210.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "id": "GO:0070059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAU5-1", "uniprot_ac": "A0AAA9SAU5", "uniprot_id": "A0AAA9SAU5_BOVIN", "mass": { "chemical_mass": 34064.0, "monoisotopic_mass": 34064.0 }, "refseq": {}, "gene_names": [ { "name": "OR2AT2B", "type": "recommended", "evidence": [ { "id": "A0AAA9SAU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SAU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2AT2B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SAU5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd13954", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13954", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242:SF253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242:SF253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEATTCNGSVGGSPVFYLVGIPSLPESLFLPVFLIFLLFYLLILMGNALILVAVVAESSLHKPMYFFLINLSALDILFTTTTVPKMLSLFLFGDHFLSFTSCLLQMYLFQSFTCSEAFILVAMAYDRYVAICRPLHYTALMTPQTNAALAASAWLTALLLPIPAVVQTSQMAYDNIARIYHCFCDHLALVQASCSDTTPQTLMGFCIAMVVSFLPLLLVLLSYAHILASVLRIGSREGRSKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIVGNVVYAILTPVLNPLIYTLRNKDVKAAITKVT", "length": 310, "header": "tr|A0AAA9SAU5-1|A0AAA9SAU5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2AT2B PE=3 SV=1 CANONICAL=A0AAA9SAU5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5/entry#A0AAA9SAU5-1", "sequence": { "sequence": "MEATTCNGSVGGSPVFYLVGIPSLPESLFLPVFLIFLLFYLLILMGNALILVAVVAESSLHKPMYFFLINLSALDILFTTTTVPKMLSLFLFGDHFLSFTSCLLQMYLFQSFTCSEAFILVAMAYDRYVAICRPLHYTALMTPQTNAALAASAWLTALLLPIPAVVQTSQMAYDNIARIYHCFCDHLALVQASCSDTTPQTLMGFCIAMVVSFLPLLLVLLSYAHILASVLRIGSREGRSKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIVGNVVYAILTPVLNPLIYTLRNKDVKAAITKVT", "length": 310, "header": "tr|A0AAA9SAU5-1|A0AAA9SAU5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2AT2B PE=3 SV=1 CANONICAL=A0AAA9SAU5-1" }, "locus": { "chromosome": "15", "start_pos": 54328756, "end_pos": 54327827, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092006.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092006.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083221.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083221.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 295, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 70, "end_pos": 72 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAU8-1", "uniprot_ac": "A0AAA9SAU8", "uniprot_id": "A0AAA9SAU8_BOVIN", "mass": { "chemical_mass": 27849.0, "monoisotopic_mass": 27849.0 }, "refseq": {}, "gene_names": [ { "name": "TNFSF18", "type": "recommended", "evidence": [ { "id": "A0AAA9SAU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ] } ], "protein_names": [ { "name": "Tumor necrosis factor ligand superfamily member 18", "type": "recommended", "evidence": [ { "id": "A0AAA9SAU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8/entry#names_and_taxonomy" } ] }, { "name": "Glucocorticoid-induced TNF-related ligand", "type": "synonym", "evidence": [ { "id": "A0AAA9SAU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8#function" }, { "database": "UniProtKB", "id": "ARBA00059256", "url": "https://www.uniprot.org/uniprotkb/ARBA00059256#function" }, { "database": "UniProtKB", "id": "A0AAA9TDR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR7#function" }, { "database": "UniProtKB", "id": "G3N2P4", "url": "https://www.uniprot.org/uniprotkb/G3N2P4#function" }, { "database": "UniProtKB", "id": "A0AAA9TQ68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFSF18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8", "locus": { "chromosome": "16", "start_pos": 40651795, "end_pos": 40788904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047412", "url": "https://www.ensembl.org/id/ENSBTAG00000047412" } ] } } ], "crossref": [ { "id": "A0AAA9SAU8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15267:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15267:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2P4", "url": "https://www.uniprot.org/uniprotkb/G3N2P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2P4-1", "url": "https://www.uniprot.org/uniprotkb/G3N2P4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKTPPTRLHRPWDSPGKNTGVGCHFLLQCMKVKSESEVTQSCPTLRDTMDYSLPGSSIHGISQLSFLQTMSLSHMENMPLSHSSLQGAQRPSWKQWLFYSTVIIVLLLCSFSALIFTFLPLKTAQGPCVAKFGPLPSKWQMPSPEPSCVNKTADWRLKILQNGLYLIYGQVAPNTAYKGRAPFEVQLRKNEDPIQALTNNSMIQNVGGAYEFHAGDVIDLIFNAEHQVLKNKTYWGIFLLTNPQFIS", "length": 248, "header": "tr|A0AAA9SAU8-1|A0AAA9SAU8_BOVIN Isoform 1 of Tumor necrosis factor ligand superfamily member 18 OS=Bos taurus OX=9913 GN=TNFSF18 PE=3 SV=1 CANONICAL=A0AAA9SAU8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8/entry#A0AAA9SAU8-1", "sequence": { "sequence": "MEKTPPTRLHRPWDSPGKNTGVGCHFLLQCMKVKSESEVTQSCPTLRDTMDYSLPGSSIHGISQLSFLQTMSLSHMENMPLSHSSLQGAQRPSWKQWLFYSTVIIVLLLCSFSALIFTFLPLKTAQGPCVAKFGPLPSKWQMPSPEPSCVNKTADWRLKILQNGLYLIYGQVAPNTAYKGRAPFEVQLRKNEDPIQALTNNSMIQNVGGAYEFHAGDVIDLIFNAEHQVLKNKTYWGIFLLTNPQFIS", "length": 248, "header": "tr|A0AAA9SAU8-1|A0AAA9SAU8_BOVIN Isoform 1 of Tumor necrosis factor ligand superfamily member 18 OS=Bos taurus OX=9913 GN=TNFSF18 PE=3 SV=1 CANONICAL=A0AAA9SAU8-1" }, "locus": { "chromosome": "16", "start_pos": 40768390, "end_pos": 40654566, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091393.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091393.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080585.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080585.1" } ] } }, { "isoform_ac": "A0AAA9TDR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8/entry#A0AAA9TDR7-1", "sequence": { "sequence": "MSQPDLNFTITGSLPFFSGKKPAAMSCWSLGEVAPRFCFKCPTRLHRPWDSPGKNTGVGCHFLLQCMKVKSESEVTQSCPTLRDTMDYSLPGSSIHGISQTAQGPCVAKFGPLPSKWQMPSPEPSCVNKTADWRLKILQNGLYLIYGQVAPNTAYKGRAPFEVQLRKNEDPIQALTNNSMIQNVGGAYEFHAGDVIDLIFNAEHQVLKNKTYWGIFLLTNPQFIS", "length": 225, "header": "tr|A0AAA9TDR7-1|A0AAA9TDR7_BOVIN Computationally mapped isoform of Tumor necrosis factor ligand superfamily member 18 OS=Bos taurus OX=9913 GN=TNFSF18 PE=3 SV=1 CANONICAL=A0AAA9SAU8-1" }, "locus": { "chromosome": "16", "start_pos": 40788876, "end_pos": 40654566, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096272.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096272.1" } ] } }, { "isoform_ac": "A0AAA9TQ68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8/entry#A0AAA9TQ68-1", "sequence": { "sequence": "MEKTPLSFLQTMSLSHMENMPLSHSSLQGAQRPSWKQWLFYSTVIIVLLLCSFSALIFTFLPLKTAQGPCVAKFGPLPSKWQMPSPEPSCVNKTADWRLKILQNGLYLIYGQVAPNTAYKGRAPFEVQLRKNEDPIQALTNNSMIQNVGGAYEFHAGDVIDLIFNAEHQVLKNKTYWGIFLLTNPQFIS", "length": 189, "header": "tr|A0AAA9TQ68-1|A0AAA9TQ68_BOVIN Computationally mapped isoform of Tumor necrosis factor ligand superfamily member 18 OS=Bos taurus OX=9913 GN=TNFSF18 PE=3 SV=1 CANONICAL=A0AAA9SAU8-1" }, "locus": { "chromosome": "16", "start_pos": 40768390, "end_pos": 40654566, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109455.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109455.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099432.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099432.1" } ] } }, { "isoform_ac": "G3N2P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8/entry#G3N2P4-1", "sequence": { "sequence": "MSQPDLNFTITGSLPFFSGKKPAAMSCWSLGEVAPRFCFKCLSFLQTMSLSHMENMPLSHSSLQGAQRPSWKQWLFYSTVIIVLLLCSFSALIFTFLPLKTAQGPCVAKFGPLPSKWQMPSPEPSCVNKTADWRLKILQNGLYLIYGQVAPNTAYKGRAPFEVQLRKNEDPIQALTNNSMIQNVGGAYEFHAGDVIDLIFNAEHQVLKNKTYWGIFLLTNPQFIS", "length": 225, "header": "tr|G3N2P4-1|G3N2P4_BOVIN Computationally mapped isoform of Tumor necrosis factor ligand superfamily member 18 OS=Bos taurus OX=9913 GN=TNFSF18 PE=3 SV=1 CANONICAL=A0AAA9SAU8-1" }, "locus": { "chromosome": "16", "start_pos": 40788876, "end_pos": 40654566, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064406.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064406.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056161.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056161.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of cell adhesion", "id": "GO:0045785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "positive regulation of leukocyte migration", "id": "GO:0002687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002687", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "T cell proliferation involved in immune response", "id": "GO:0002309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002309", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" }, { "name": "regulation of macromolecule metabolic process", "id": "GO:0060255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU8" }, { "id": "PS50049", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50049" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THD", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 241, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 232, "end_pos": 234 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAV4-1", "uniprot_ac": "A0AAA9SAV4", "uniprot_id": "A0AAA9SAV4_BOVIN", "mass": { "chemical_mass": 30939.0, "monoisotopic_mass": 30939.0 }, "refseq": { "ac": "XP_002686167", "name": "V-set domain-containing T-cell activation inhibitor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686167" }, "gene_names": [ { "name": "VTCN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ] }, { "name": "VTCN1", "type": "synonym", "evidence": [ { "id": "XP_002686167", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686167" } ] } ], "protein_names": [ { "name": "V-set domain containing T cell activation inhibitor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4/entry#names_and_taxonomy" } ] }, { "name": "V-set domain-containing T-cell activation inhibitor 1", "type": "synonym", "evidence": [ { "id": "XP_002686167", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686167" } ] } ], "function": [ { "annotation": "Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZR3#function" }, { "database": "UniProtKB", "id": "ARBA00057839", "url": "https://www.uniprot.org/uniprotkb/ARBA00057839#function" }, { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4#function" }, { "database": "UniProtKB", "id": "A0AAA9TY64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY64#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VTCN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4", "locus": { "chromosome": "3", "start_pos": 26066037, "end_pos": 26012214, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062774", "url": "https://www.ensembl.org/id/ENSBTAG00000062774" } ] } } ], "crossref": [ { "id": "A0AAA9SAV4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20984", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20984", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539919", "url": "https://www.ncbi.nlm.nih.gov/gene/539919", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539919", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539919", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYIVTSK", "url": "https://omabrowser.org/oma/group/CYIVTSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002686167", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686167", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6R6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6R6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6R6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLGQVIFWSIISIIIILAGAIVFIIGFGISGRRSITVTTLTSAGNIGEDGILSCTFEPDIKLADIVIQWLKEGVMGLVHEFKEGKDVLSDQDEMFRGRTAVFSDQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSIPEVNVDYNASSESLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSILYNVTINNTYSCMIENNIAKATGDIKVTDSEIKRRSHLQLLNSKASLRVSASSAIDWVLLPLCFYLTLK", "length": 282, "header": "tr|A0AAA9SAV4-1|A0AAA9SAV4_BOVIN Isoform 1 of V-set domain containing T cell activation inhibitor 1 OS=Bos taurus OX=9913 GN=VTCN1 PE=3 SV=1 CANONICAL=A0AAA9SAV4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4/entry#A0AAA9SAV4-1", "sequence": { "sequence": "MASLGQVIFWSIISIIIILAGAIVFIIGFGISGRRSITVTTLTSAGNIGEDGILSCTFEPDIKLADIVIQWLKEGVMGLVHEFKEGKDVLSDQDEMFRGRTAVFSDQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSIPEVNVDYNASSESLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSILYNVTINNTYSCMIENNIAKATGDIKVTDSEIKRRSHLQLLNSKASLRVSASSAIDWVLLPLCFYLTLK", "length": 282, "header": "tr|A0AAA9SAV4-1|A0AAA9SAV4_BOVIN Isoform 1 of V-set domain containing T cell activation inhibitor 1 OS=Bos taurus OX=9913 GN=VTCN1 PE=3 SV=1 CANONICAL=A0AAA9SAV4-1" }, "locus": { "chromosome": "3", "start_pos": 26065989, "end_pos": 26012289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081038.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081038.1" } ] } }, { "isoform_ac": "A0AAA9SZR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4/entry#A0AAA9SZR3-1", "sequence": { "sequence": "MSGWWSFSIISIIIILAGAIVFIIGFGISGRRSITVTTLTSAGNIGEDGILSCTFEPDIKLADIVIQWLKEGVMGLVHEFKEGKDVLSDQDEMFRGRTAVFSDQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSIPEVNVDYNASSESLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSILYNVTINNTYSCMIENNIAKATGDIKVTDSEIKRRSHLQLLNSKASLRVSASSAIDWVLLPLCFYLTLK", "length": 279, "header": "tr|A0AAA9SZR3-1|A0AAA9SZR3_BOVIN Computationally mapped isoform of V-set domain containing T cell activation inhibitor 1 OS=Bos taurus OX=9913 GN=VTCN1 PE=3 SV=1 CANONICAL=A0AAA9SAV4-1" }, "locus": { "chromosome": "3", "start_pos": 26065989, "end_pos": 26044959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105748.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105748.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089603.1" } ] } }, { "isoform_ac": "A0AAA9TY64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4/entry#A0AAA9TY64-1", "sequence": { "sequence": "IISIIIILAGAIVFIIGFGISGRRSITVTTLTSAGNIGEDGILSCTFEPDIKLADIVIQWLKEGVMGLVHEFKEGKDVLSDQDEMFRGRTAVFSDQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSIPEVNVDYNASSESLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSILYNVTINNTYSCMIENNIAKATGDIKVTDSEIKRRSHLQLLNSKASLRVSASSAIDWVLLPLCFYLTLK", "length": 271, "header": "tr|A0AAA9TY64-1|A0AAA9TY64_BOVIN Computationally mapped isoform of V-set domain containing T cell activation inhibitor 1 OS=Bos taurus OX=9913 GN=VTCN1 PE=3 SV=2 CANONICAL=A0AAA9SAV4-1" }, "locus": { "chromosome": "3", "start_pos": 26065989, "end_pos": 26045571, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093537.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093537.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103297.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103297.2" } ] } }, { "isoform_ac": "A0ABI0P6R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4/entry#A0ABI0P6R6-1", "sequence": { "sequence": "MASLGQVIFWSIISIIIILAGAIVFIIGFGISAFSIPEVNVDYNASSESLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSILYNVTINNTYSCMIENNIAKATGDIKVTDSEIKRRSHLQLLNSKASLRVSASSAIDWVLLPLCFYLTLK", "length": 166, "header": "tr|A0ABI0P6R6-1|A0ABI0P6R6_BOVIN Computationally mapped isoform of V-set domain containing T cell activation inhibitor 1 OS=Bos taurus OX=9913 GN=VTCN1 PE=4 SV=1 CANONICAL=A0AAA9SAV4-1" }, "locus": { "chromosome": "3", "start_pos": 26065989, "end_pos": 26012289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019233.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019233.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106958.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539919", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539919", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SAY4-1", "protein_name": "V-set domain containing T cell activation inhibitor 1", "gene_name": "VTCN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASLGQVVFWSIISIIIILAGAIAFIIGFGISGRHSITVTTLTSAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVTGLVHEFKKGKDDLSDQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNAKLEYKTGAFSIPEVNVDSNASSESLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNPENVTMKVVSVLYNVTINTTYSCMIENDIAKATGDIRVTDSEIKRQSHLQLLNSKASLCLSSFVAISWVLLPLCPYLMLK", "length": 282 }, "evidence": [ { "id": "A0AAA9SAV4", "url": "https://omabrowser.org/oma/group/A0AAA9SAV4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q501W4-1", "protein_name": "V-set domain-containing T-cell activation inhibitor 1", "gene_name": "Vtcn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASLGQIIFWSIINVIIILAGAIVLIIGFGISGKHFITVTTFTSAGNIGEDGTLSCTFEPDIKLNGIVIQWLKEGIKGLVHEFKEGKDDLSQQHEMFRGRTAVFADQVVVGNASLRLKNVQLTDAGTYTCYIHTSKGKGNANLEYKTGAFSMPEINVDYNASSESLRCEAPRWFPQPTVAWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTDSEVKRRSQLELLNSGPSPCVSSVSAAGWALLSLSCCLMLR", "length": 282 }, "evidence": [ { "id": "A0AAA9SAV4", "url": "https://omabrowser.org/oma/group/A0AAA9SAV4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TSP5-1", "protein_name": "V-set domain containing T-cell activation inhibitor 1", "gene_name": "Vtcn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLGQIIFWSIINIIIILAGAIALIIGFGISGKHFITVTTFTSAGNIGEDGTLSCTFEPDIKLNGIVIQWLKEGIKGLVHEFKEGKDDLSQQHEMFRGRTAVFADQVVVGNASLRLKNVQLTDAGTYTCYIRTSKGKGNANLEYKTGAFSMPEINVDYNASSESLRCEAPRWFPQPTVAWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTDSEVKRRSQLQLLNSGPSPCVFSSAFVAGWALLSLSCCLMLR", "length": 283 }, "evidence": [ { "id": "A0AAA9SAV4", "url": "https://omabrowser.org/oma/group/A0AAA9SAV4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z7D3-1", "protein_name": "V-set domain-containing T-cell activation inhibitor 1", "gene_name": "VTCN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK", "length": 282 }, "evidence": [ { "id": "A0AAA9SAV4", "url": "https://omabrowser.org/oma/group/A0AAA9SAV4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" }, { "name": "negative regulation of T cell proliferation", "id": "GO:0042130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042130", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" }, { "name": "negative regulation of T cell activation", "id": "GO:0050868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050868", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" }, { "name": "regulation of T cell proliferation", "id": "GO:0042129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042129", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAV4" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 132, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 160, "end_pos": 162 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 220, "end_pos": 222 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB03-1", "uniprot_ac": "A0AAA9SB03", "uniprot_id": "A0AAA9SB03_BOVIN", "mass": { "chemical_mass": 132096.0, "monoisotopic_mass": 132096.0 }, "refseq": {}, "gene_names": [ { "name": "CATSPERG", "type": "recommended", "evidence": [ { "id": "A0AAA9SB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" } ] } ], "protein_names": [ { "name": "Cation channel sperm associated auxiliary subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9SB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CATSPERG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03", "locus": { "chromosome": "18", "start_pos": 48178203, "end_pos": 48147915, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000621", "url": "https://www.ensembl.org/id/ENSBTAG00000000621" } ] } } ], "crossref": [ { "id": "A0AAA9SB03", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB03", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR028246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14327", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14327", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14327:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14327:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15064", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15064", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22846", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22846", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22851", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22851", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SB03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T556", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T556", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T556-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T556-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPVGPAPWPRLRVLWALWALLVVLLAPWRLWAIQETQECTWQVVLNNLESVGKNDAIDHFVDQELYTVDKVFDLLVDAPIDRDETYLGFPYYLKINYSCTGEVSSEALVRKGHLTGLKPVVLVTFQSPVNFHRWKIEQLQIQMEAAPFRSPERCDAEEVCLMSWYTPMPIKNGSVVMRVDVSSNGLGPFIPNKRFHVNINGFLERGRDHELQFTVGNELFHLIPRHFVNVPSRPLWYTVDQTPVLILGGIPEEKAILLTDTNFKDFFLVELSIDSCWVGSFYCPQASFTATIYDAIATESTLFIRQNQLIYYFTGTYTTLYENNHGSGEGWVRVLANECIKRLCPVHFHSNGSEYVMALTAGKNEGYVHFGTITDGLVSFKLLPRDRSVCNAILVDNCSITWAVFIAGDYNLLMLVEIVGPTSSKYFQVVSYDLVSDYLVVLYTIPEFIPDARGLEFLMILGTESYTNFPMVPKGMSYNPYNNLLLIWGNFLLQSFNSENFIYLADFPKELSIKYLVNSFRGDMAIVTENEEIWYLLEGSYQVYQLFPSKAWEVYISLQVLQQSSRYAPNETMVTLFYEDNKLYQLVYLIDNQQGRLIKRLMPVEQLLMYQQISKEYVLERQGSHLTLSFSNFCPFTVMRLQELPNPQIYTRQERYRAQPPRVLEPWGFHSENSLAVYQGLVYYLLSLHSKYDKPYADPVHDPTWRWWKNKKQDQDYYFYLANNWRSTGSVHVDMTSYEKIYDLKAENELPERIFLDKGTSYSFSVFLTTRKPEVQHAGPSFQVLSPVDLAVVLADPDCIEAMVKEKVLVNRNSVLFWVTLSDKRSCFDQGISGHHLMKTSMLVKVLGSSGHCFQNTNRGPRMQSNLMVPVLIGCPPGKRLAFDITYTLQYNRVQNKHYFDCVKVDPEMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSYVLKVVGGGPTLDTIKEYSEEEIYRFNSPLDKTGSLIWTTENTTTTEDLAFNIMSHNSLGIEWLCLENSPCHDTIPHNIFAPEFFFKVLVSNRGVDESTYCDYQLTFLLHIHGLPLSARRAFLILLVSASLFVGLVILYIVCCLLSPYMVKVCNILRWKINSIIGLESNYTYSTPSDSRAFSHSGTVSWRSSRLNSRVVYKGAEENKAET", "length": 1149, "header": "tr|A0AAA9SB03-1|A0AAA9SB03_BOVIN Isoform 1 of Cation channel sperm associated auxiliary subunit gamma OS=Bos taurus OX=9913 GN=CATSPERG PE=4 SV=2 CANONICAL=A0AAA9SB03-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03/entry#A0AAA9SB03-1", "sequence": { "sequence": "MFPVGPAPWPRLRVLWALWALLVVLLAPWRLWAIQETQECTWQVVLNNLESVGKNDAIDHFVDQELYTVDKVFDLLVDAPIDRDETYLGFPYYLKINYSCTGEVSSEALVRKGHLTGLKPVVLVTFQSPVNFHRWKIEQLQIQMEAAPFRSPERCDAEEVCLMSWYTPMPIKNGSVVMRVDVSSNGLGPFIPNKRFHVNINGFLERGRDHELQFTVGNELFHLIPRHFVNVPSRPLWYTVDQTPVLILGGIPEEKAILLTDTNFKDFFLVELSIDSCWVGSFYCPQASFTATIYDAIATESTLFIRQNQLIYYFTGTYTTLYENNHGSGEGWVRVLANECIKRLCPVHFHSNGSEYVMALTAGKNEGYVHFGTITDGLVSFKLLPRDRSVCNAILVDNCSITWAVFIAGDYNLLMLVEIVGPTSSKYFQVVSYDLVSDYLVVLYTIPEFIPDARGLEFLMILGTESYTNFPMVPKGMSYNPYNNLLLIWGNFLLQSFNSENFIYLADFPKELSIKYLVNSFRGDMAIVTENEEIWYLLEGSYQVYQLFPSKAWEVYISLQVLQQSSRYAPNETMVTLFYEDNKLYQLVYLIDNQQGRLIKRLMPVEQLLMYQQISKEYVLERQGSHLTLSFSNFCPFTVMRLQELPNPQIYTRQERYRAQPPRVLEPWGFHSENSLAVYQGLVYYLLSLHSKYDKPYADPVHDPTWRWWKNKKQDQDYYFYLANNWRSTGSVHVDMTSYEKIYDLKAENELPERIFLDKGTSYSFSVFLTTRKPEVQHAGPSFQVLSPVDLAVVLADPDCIEAMVKEKVLVNRNSVLFWVTLSDKRSCFDQGISGHHLMKTSMLVKVLGSSGHCFQNTNRGPRMQSNLMVPVLIGCPPGKRLAFDITYTLQYNRVQNKHYFDCVKVDPEMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSYVLKVVGGGPTLDTIKEYSEEEIYRFNSPLDKTGSLIWTTENTTTTEDLAFNIMSHNSLGIEWLCLENSPCHDTIPHNIFAPEFFFKVLVSNRGVDESTYCDYQLTFLLHIHGLPLSARRAFLILLVSASLFVGLVILYIVCCLLSPYMVKVCNILRWKINSIIGLESNYTYSTPSDSRAFSHSGTVSWRSSRLNSRVVYKGAEENKAET", "length": 1149, "header": "tr|A0AAA9SB03-1|A0AAA9SB03_BOVIN Isoform 1 of Cation channel sperm associated auxiliary subunit gamma OS=Bos taurus OX=9913 GN=CATSPERG PE=4 SV=2 CANONICAL=A0AAA9SB03-1" }, "locus": { "chromosome": "18", "start_pos": 48177282, "end_pos": 48147944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108524.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108524.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081083.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081083.2" } ] } }, { "isoform_ac": "A0AAA9T556-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03/entry#A0AAA9T556-1", "sequence": { "sequence": "MFPVGPAPWPRLRVLWALWALLVVLLAPWRLWAIQETQECTWQVVLNNLESVGKNDAIDHFVDQELYTVDKVFDLLVDAPIDRDETYLGFPYYLKINYSCTGEVSSEALVRKGHLTGLKPVVLVTFQSPVNFHRWKIEQLQIQMEAAPFRSPERCDAEEVCLMSWYTPMPIKNGSVVMRVDVSSNGLGPFIPNKRFHVNINGFLERGRDHELQFTVGNELFHLIPRHFVNVPSRPLWYTVDQTPVLILGGIPEEKAILLTDTNFKDFFLVELSIDSCWVGSFYCPQASFTATIYDAIATESTLFIRQNQLIYYFTGTYTTLYENNHGSGEGWVRVLANECIKRLCPVHFHSNGSEYVMALTAGKNEGYVHFGTITDGLVSFKLLPRDRSVCNAILVSDYLVVLYTIPEFIPDARGLEFLMILGTESYTNFPMVPKGMSYNPYNNLLLIWGNFLLQSFNSENFIYLADFPKELSIKYLVNSFRGDMAIVTENEEIWYLLEGSYQVYQLFPSKAWEVYISLQVLQQSSRYAPNETMVTLFYEDNKLYQLVYLIDNQQGRLIKRLMPVEQLLMYQQISKEYVLERQGSHLTLSFSNFCPFTVMRLQELPNPQIYTRQERYRAQPPRVLEPWGFHSENSLAVYQGLVYYLLSLHSKYDKPYADPVHDPTWRWWKNKKQDQDYYFYLANNWRSTGSVHVDMTSYEKIYDLKAENELPERIFLDKGTSYSFSWCRGAGFAGPSFQVLSPVDLAVVLADPDCIEAMVKEKVLVNRNSVLFWVTLSDKRSCFDQGISGHHLMKTSMLVKVLGSSGHCFQNTNRGPRMQSNLMVPVLIGCPPGKRLAFDITYTLQYNRVQNKHYFDCVKVDPEMPCFLFRDIFYPFFLIQDLVTGDSGSFQGSYVLKVVGGGPTLDTIKEYSEEEIYRFNSPLDKTGSLIWTTENTTTTEDLAFNIMSHNSLGIEWLCLENSPCHDTIPHNIFAPEFFFKVLVSNRGVDESTYCDYQLTFLLHIHGLPLSARRAFLILLVSASLFVGLVILYIVCCLLSPYMVKVCNILRWKINSIIGLESNYTYSTPSDSRAFSHSGTVSWRSSRLNSRVVYKGAEENKAET", "length": 1104, "header": "tr|A0AAA9T556-1|A0AAA9T556_BOVIN Computationally mapped isoform of Cation channel sperm associated auxiliary subunit gamma OS=Bos taurus OX=9913 GN=CATSPERG PE=4 SV=2 CANONICAL=A0AAA9SB03-1" }, "locus": { "chromosome": "18", "start_pos": 48177282, "end_pos": 48147944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090861.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090861.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1113, "start_aa": "Thr", "end_pos": 1113, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1113", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 423, "start_aa": "Thr", "end_pos": 423, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr423", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "CatSper complex", "id": "GO:0036128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036128", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1108, "end_pos": 1110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 398, "end_pos": 400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" }, { "start_pos": 981, "end_pos": 983, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" }, { "id": "PF22846", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22846" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CATSPERG C-terminal", "eco_id": "ECO_0000259", "start_pos": 899, "end_pos": 1100, "start_aa": "His", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" }, { "id": "PF22851", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22851" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CATSPERG Ig-like", "eco_id": "ECO_0000259", "start_pos": 750, "end_pos": 873, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" }, { "id": "PF22840", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22840" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CATSPERG N-terminal", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 199, "start_aa": "Cys", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB03" }, { "id": "PF15064", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15064" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CATSPERG beta-propeller", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 646, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 423, 1113 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1108, "end_pos": 1110 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 398, "end_pos": 400 }, { "start_pos": 571, "end_pos": 573 }, { "start_pos": 97, "end_pos": 99 }, { "start_pos": 981, "end_pos": 983 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB06-1", "uniprot_ac": "A0AAA9SB06", "uniprot_id": "A0AAA9SB06_BOVIN", "mass": { "chemical_mass": 35673.0, "monoisotopic_mass": 35673.0 }, "refseq": {}, "gene_names": [ { "name": "OR9K2J", "type": "recommended", "evidence": [ { "id": "A0AAA9SB06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SB06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9K2J", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06", "locus": {} } ], "crossref": [ { "id": "A0AAA9SB06", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB06", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SB06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDRETSNHSEVTDFILVGFKVHPEFHILLFLFFLLVYAMILLGNVGMMVIIITDPRLNTPMYFFLGNLSFVDLFYSSVIAPKAMSNFWSESKSISYAGCVTQLFLFDLFIVSEGFLLAVMAYDRFIAICNPLLYSVQMSTHLCVQFVAGSYFFGCISSVLQTIMTFTLSFCASRNIDHFYCDERPLLRISCSDLYIPNMVSFFLCTIIILPTIIVIIVSYIYIVSTVLKIRSTEGRKKVFSTCSSHLGVVSVLYGAIIFMYVIPDRFPELSKVASLCYTLVTPMLNPLIYSLRNKDVKEALRKILGKNLFLFI", "length": 314, "header": "tr|A0AAA9SB06-1|A0AAA9SB06_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9K2J PE=3 SV=1 CANONICAL=A0AAA9SB06-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06/entry#A0AAA9SB06-1", "sequence": { "sequence": "MGDRETSNHSEVTDFILVGFKVHPEFHILLFLFFLLVYAMILLGNVGMMVIIITDPRLNTPMYFFLGNLSFVDLFYSSVIAPKAMSNFWSESKSISYAGCVTQLFLFDLFIVSEGFLLAVMAYDRFIAICNPLLYSVQMSTHLCVQFVAGSYFFGCISSVLQTIMTFTLSFCASRNIDHFYCDERPLLRISCSDLYIPNMVSFFLCTIIILPTIIVIIVSYIYIVSTVLKIRSTEGRKKVFSTCSSHLGVVSVLYGAIIFMYVIPDRFPELSKVASLCYTLVTPMLNPLIYSLRNKDVKEALRKILGKNLFLFI", "length": 314, "header": "tr|A0AAA9SB06-1|A0AAA9SB06_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9K2J PE=3 SV=1 CANONICAL=A0AAA9SB06-1" }, "locus": { "chromosome": "5", "start_pos": 59530212, "end_pos": 59529271, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126491.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126491.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080646.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB06" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 291, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 68, "end_pos": 70 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB14-1", "uniprot_ac": "A0AAA9SB14", "uniprot_id": "A0AAA9SB14_BOVIN", "mass": { "chemical_mass": 60097.0, "monoisotopic_mass": 60097.0 }, "refseq": {}, "gene_names": [ { "name": "NUP58", "type": "recommended", "evidence": [ { "id": "A0AAA9SB14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ] } ], "protein_names": [ { "name": "Nucleoporin 58", "type": "synonym", "evidence": [ { "id": "A0AAA9SB14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUP58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14", "locus": { "chromosome": "12", "start_pos": 33892576, "end_pos": 33925972, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015225", "url": "https://www.ensembl.org/id/ENSBTAG00000015225" } ] } } ], "crossref": [ { "id": "A0AAA9SB14", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB14", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR024882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13437", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13437", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13437:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13437:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15967", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15967", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R537", "url": "https://www.uniprot.org/uniprotkb/F6R537", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R537-1", "url": "https://www.uniprot.org/uniprotkb/F6R537-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTGFSFGSSTLGSSTVAAGGSSTGGGFSFGTGTSSNPTVGLNFGTLGSTATPATTSASGGFGTSLFGSKPATGFTLGGTTTGTAATTSASTIGFSLGFSKPAASATPFALPIASTSASSLTLSSALTSTPAASTGFTLNNLSGTAATTTTASTGLSLGGALTGLGGSLFQGTSTASSVMFGLFVGLGQSALGLTLGTTAATSAAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDETLPAVICQDVDNLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAASGLQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHENTAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFEARRAEAKKWQNAPRVTTGPTPFSNMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGAPFGSGIGTGLQSSGLGSSNLGGFGASSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR", "length": 593, "header": "tr|A0AAA9SB14-1|A0AAA9SB14_BOVIN Isoform 1 of Nucleoporin 58 OS=Bos taurus OX=9913 GN=NUP58 PE=4 SV=1 CANONICAL=A0AAA9SB14-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14/entry#A0AAA9SB14-1", "sequence": { "sequence": "MSTGFSFGSSTLGSSTVAAGGSSTGGGFSFGTGTSSNPTVGLNFGTLGSTATPATTSASGGFGTSLFGSKPATGFTLGGTTTGTAATTSASTIGFSLGFSKPAASATPFALPIASTSASSLTLSSALTSTPAASTGFTLNNLSGTAATTTTASTGLSLGGALTGLGGSLFQGTSTASSVMFGLFVGLGQSALGLTLGTTAATSAAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDETLPAVICQDVDNLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAASGLQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHENTAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFEARRAEAKKWQNAPRVTTGPTPFSNMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGAPFGSGIGTGLQSSGLGSSNLGGFGASSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR", "length": 593, "header": "tr|A0AAA9SB14-1|A0AAA9SB14_BOVIN Isoform 1 of Nucleoporin 58 OS=Bos taurus OX=9913 GN=NUP58 PE=4 SV=1 CANONICAL=A0AAA9SB14-1" }, "locus": { "chromosome": "12", "start_pos": 33925851, "end_pos": 33897824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083286.1" } ] } }, { "isoform_ac": "F6R537-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14/entry#F6R537-1", "sequence": { "sequence": "MSTGFSFGSSTLGSSTVAAGGSSTGGGFSFGTGTSSNPTVGLNFGTLGSTATPATTSASGGFGTSLFGSKPATGFTLGGTTTAITKTITGLTLGTAATTSASTIGFSLGFSKPAASATPFALPIASTSASSLTLSSALTSTPAASTGFTLNNLSGTAATTTTASTGLSLGGALTGLGGSLFQGTSTASSGLGQSALGLTLGTTAATSAAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDETLPAVICQDVDNLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAASGLQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHENTAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFEARRAEAKKWQNAPRVTTGPTPFSNMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGAPFGSGIGTGLQSSGLGSSNLGGFGASSGFGCSTTGASTFGFGTTNKPSGSLSAGNKSQVLTGFRKPSMTEVNELGRKIQF", "length": 568, "header": "tr|F6R537-1|F6R537_BOVIN Computationally mapped isoform of Nucleoporin 58 OS=Bos taurus OX=9913 GN=NUP58 PE=4 SV=1 CANONICAL=A0AAA9SB14-1" }, "locus": { "chromosome": "12", "start_pos": 33925851, "end_pos": 33892579, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032888.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032888.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032816.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032816.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 447, "start_aa": "Thr", "end_pos": 447, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr447", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 52, "start_aa": "Thr", "end_pos": 52, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr52", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural constituent of nuclear pore", "id": "GO:0017056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017056", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ], "pmid": "" }, { "name": "nuclear localization sequence binding", "id": "GO:0008139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB14" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 52, 447 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 548, "end_pos": 550 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB34-1", "uniprot_ac": "A0AAA9SB34", "uniprot_id": "A0AAA9SB34_BOVIN", "mass": { "chemical_mass": 41988.0, "monoisotopic_mass": 41988.0 }, "refseq": { "ac": "XP_005208984", "name": "caytaxin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208984" }, "gene_names": [ { "name": "ATCAY", "type": "recommended", "evidence": [ { "id": "A0AAA9SB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ] }, { "name": "ATCAY", "type": "synonym", "evidence": [ { "id": "XP_005208984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208984" } ] }, { "name": "caytaxin", "type": "synonym", "evidence": [ { "id": "XP_005208984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208984" } ] } ], "protein_names": [ { "name": "ATCAY kinesin light chain interacting caytaxin", "type": "synonym", "evidence": [ { "id": "A0AAA9SB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34/entry#names_and_taxonomy" } ] }, { "name": "caytaxin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208984" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATCAY", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34", "locus": { "chromosome": "7", "start_pos": 20079578, "end_pos": 20119357, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018375", "url": "https://www.ensembl.org/id/ENSBTAG00000018375" } ] } } ], "crossref": [ { "id": "A0AAA9SB34", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB34", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509463", "url": "https://www.ncbi.nlm.nih.gov/gene/509463", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12112:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12112:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208984", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208984", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTTEATLRMENMDVKEEWHDEALPRPLPEETGMDLLGSPTEDTSSPPNTLNFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVAAAKNMPGDSADLFGDGSAEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMRVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEYVLPRSEEKAEAGLAEDRSALATEDQETSMS", "length": 371, "header": "tr|A0AAA9SB34-1|A0AAA9SB34_BOVIN Isoform 1 of ATCAY kinesin light chain interacting caytaxin OS=Bos taurus OX=9913 GN=ATCAY PE=4 SV=1 CANONICAL=A0AAA9SB34-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34/entry#A0AAA9SB34-1", "sequence": { "sequence": "MGTTEATLRMENMDVKEEWHDEALPRPLPEETGMDLLGSPTEDTSSPPNTLNFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVAAAKNMPGDSADLFGDGSAEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMRVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEYVLPRSEEKAEAGLAEDRSALATEDQETSMS", "length": 371, "header": "tr|A0AAA9SB34-1|A0AAA9SB34_BOVIN Isoform 1 of ATCAY kinesin light chain interacting caytaxin OS=Bos taurus OX=9913 GN=ATCAY PE=4 SV=1 CANONICAL=A0AAA9SB34-1" }, "locus": { "chromosome": "7", "start_pos": 20116626, "end_pos": 20080582, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107068.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107068.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082580.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082580.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "pmid": "" }, { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "pmid": "" }, { "name": "negative regulation of glutamate metabolic process", "id": "GO:2000212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB34" }, { "id": "PS50191", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRAL-TRIO", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 328, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB40-1", "uniprot_ac": "A0AAA9SB40", "uniprot_id": "A0AAA9SB40_BOVIN", "mass": { "chemical_mass": 34746.0, "monoisotopic_mass": 34746.0 }, "refseq": { "ac": "XP_059739050", "name": "KATNB1-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739050" }, "gene_names": [ { "name": "LOC784488", "type": "recommended", "evidence": [ { "id": "A0AAA9SB40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40" } ] }, { "name": "LOC784488", "type": "synonym", "evidence": [ { "id": "XP_059739050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739050" } ] } ], "protein_names": [ { "name": "Katanin p80 subunit C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SB40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40/entry#names_and_taxonomy" } ] }, { "name": "KATNB1-like protein 1", "type": "synonym", "evidence": [ { "id": "XP_059739050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739050" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC784488", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40", "locus": {} } ], "crossref": [ { "id": "A0AAA9SB40", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB40", "database": "AlphaFoldDB", "categories": [] }, { "id": "784488", "url": "https://www.ncbi.nlm.nih.gov/gene/784488", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784488", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784488", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14682", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14682", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14682:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14682:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13925", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13925", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739050", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739050", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASETHNVKKRNFCNHTEDHSIDLPRKRISNFTNKNMKEVKKSPKQLATYITRTVGQAVKSPGKLRKVIYRRKKVHHPIQNPCYRKKQSPKSGGCVMANKENELACAGHLPEKLRPDSRTYLINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCIDLLPLVKSLLKSRFEEYIIVGLNWLQAVIKRWWSELSSKTEIMNDGNIQILKQQLSGLWEQENHLTLVPGYTGNIAKDVDAYLLQLH", "length": 304, "header": "tr|A0AAA9SB40-1|A0AAA9SB40_BOVIN Isoform 1 of Katanin p80 subunit C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC784488 PE=4 SV=1 CANONICAL=A0AAA9SB40-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40/entry#A0AAA9SB40-1", "sequence": { "sequence": "MASETHNVKKRNFCNHTEDHSIDLPRKRISNFTNKNMKEVKKSPKQLATYITRTVGQAVKSPGKLRKVIYRRKKVHHPIQNPCYRKKQSPKSGGCVMANKENELACAGHLPEKLRPDSRTYLINTSDSGSSQTESPSSKYSGFFSEVSQDHETMAQVLFSRNLRLNVALTFWRKRSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCIDLLPLVKSLLKSRFEEYIIVGLNWLQAVIKRWWSELSSKTEIMNDGNIQILKQQLSGLWEQENHLTLVPGYTGNIAKDVDAYLLQLH", "length": 304, "header": "tr|A0AAA9SB40-1|A0AAA9SB40_BOVIN Isoform 1 of Katanin p80 subunit C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC784488 PE=4 SV=1 CANONICAL=A0AAA9SB40-1" }, "locus": { "chromosome": "29", "start_pos": 30569023, "end_pos": 30568112, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120112.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120112.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082585.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082585.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784488", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784488", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB40" }, { "id": "PF13925", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13925" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Katanin p80 subunit C-terminal", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 299, "start_aa": "Gln", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 31, "end_pos": 33 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB48-1", "uniprot_ac": "A0AAA9SB48", "uniprot_id": "A0AAA9SB48_BOVIN", "mass": { "chemical_mass": 76219.0, "monoisotopic_mass": 76219.0 }, "refseq": {}, "gene_names": [ { "name": "NCKIPSD", "type": "recommended", "evidence": [ { "id": "A0AAA9SB48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ] } ], "protein_names": [ { "name": "NCK interacting protein with SH3 domain", "type": "synonym", "evidence": [ { "id": "A0AAA9SB48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCKIPSD", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48", "locus": { "chromosome": "22", "start_pos": 51214042, "end_pos": 51201286, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021850", "url": "https://www.ensembl.org/id/ENSBTAG00000021850" } ] } } ], "crossref": [ { "id": "A0AAA9SB48", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB48", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021850", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021850", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11849", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11849", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018556", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018556", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BG80", "url": "https://www.orthodb.org/?gene=E1BG80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13357:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13357:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG80", "url": "https://www.uniprot.org/uniprotkb/E1BG80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG80-1", "url": "https://www.uniprot.org/uniprotkb/E1BG80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNAAMRDGGKYSLEQRGILQKLIHHRKETLSRRGPSAPSAAAMTPSTSDHHLDAAATRQPNGMCRAGFERQHSLPSSEYLGADGGLYQIPPQPRRAAPTTPPPPVKRRDRDALMVLGSGGRNTTPSGGSSVSSGGSVSSTSLDTLYTGSSSSELGPSCSPTPPPVPRRGALTAVSQAQPPPCKVPNPEPPTEEEAAAAVVETAPAPALDELEALGALNLGATEEKAVAEPAVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQASVPASSPVMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRVSLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAPDQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSILKFLQDVFASPTTAAIFYHTDMMALIDITVRHIADLSPGDKHRHRLPDLQATLRRILAEEEASPQCQMDRMIVQEMCKEFPVLGEAPS", "length": 700, "header": "tr|A0AAA9SB48-1|A0AAA9SB48_BOVIN Isoform 1 of NCK interacting protein with SH3 domain OS=Bos taurus OX=9913 GN=NCKIPSD PE=4 SV=1 CANONICAL=A0AAA9SB48-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48/entry#A0AAA9SB48-1", "sequence": { "sequence": "MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNAAMRDGGKYSLEQRGILQKLIHHRKETLSRRGPSAPSAAAMTPSTSDHHLDAAATRQPNGMCRAGFERQHSLPSSEYLGADGGLYQIPPQPRRAAPTTPPPPVKRRDRDALMVLGSGGRNTTPSGGSSVSSGGSVSSTSLDTLYTGSSSSELGPSCSPTPPPVPRRGALTAVSQAQPPPCKVPNPEPPTEEEAAAAVVETAPAPALDELEALGALNLGATEEKAVAEPAVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQASVPASSPVMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRVSLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAPDQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSILKFLQDVFASPTTAAIFYHTDMMALIDITVRHIADLSPGDKHRHRLPDLQATLRRILAEEEASPQCQMDRMIVQEMCKEFPVLGEAPS", "length": 700, "header": "tr|A0AAA9SB48-1|A0AAA9SB48_BOVIN Isoform 1 of NCK interacting protein with SH3 domain OS=Bos taurus OX=9913 GN=NCKIPSD PE=4 SV=1 CANONICAL=A0AAA9SB48-1" }, "locus": { "chromosome": "22", "start_pos": 51213038, "end_pos": 51201358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126183.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126183.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082595.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082595.1" } ] } }, { "isoform_ac": "E1BG80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48/entry#E1BG80-1", "sequence": { "sequence": "MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNAAMRDGGKYSLEQRGILQKLIHHRKETLSRRGPSAPSAAAMTPSTSDHHLDAAATRQPNGMCRAGFERQHSLPSSEYLGADGGLYQIPPQPRRAAPTTPPPPVKRRDRDALMVLGSGGRNTTPSGGSSVSSGGSVSSTSLDTLYTGSSSSELGPSCSPTPPPVPRRGALTAVSQAQPPPCKVPNPEPPTEEEAAAAVVETAPAPALDELEALGALNLGATEEKAVAEPAVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHIQASVPASSPVMEQVLLSLVEGKTDADPEVCKKMCKRNEFESVLALVAYYQMEHRVSLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLSIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAPDQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSILKFLQDVFASPTTAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAVVRSTPYLQHRHRLPDLQATLRRILAEEEASPQCQMDRMIVQEMCKEFPVLGEAPS", "length": 663, "header": "tr|E1BG80-1|A0AAA9SB48_BOVIN Computationally mapped isoform of NCK interacting protein with SH3 domain OS=Bos taurus OX=9913 GN=NCKIPSD PE=4 SV=4 CANONICAL=A0AAA9SB48-1" }, "locus": { "chromosome": "22", "start_pos": 51213038, "end_pos": 51201358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029131.8", "url": "https://www.ensembl.org/id/ENSBTAT00000029131.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029131.7", "url": "https://www.ensembl.org/id/ENSBTAP00000029131.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 235, "start_aa": "Thr", "end_pos": 235, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr235", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2029482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "resource": "Reactome", "description": "Regulation of actin dynamics for phagocytic cup formation" }, { "id": "R-BTA-5663213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663213", "resource": "Reactome", "description": "RHO GTPases Activate WASPs and WAVEs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ], "pmid": "" }, { "name": "COP9 signalosome", "id": "GO:0008180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008180", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "Arp2/3 complex binding", "id": "GO:0071933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071933", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB48" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 58, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 235 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB58-1", "uniprot_ac": "A0AAA9SB58", "uniprot_id": "A0AAA9SB58_BOVIN", "mass": { "chemical_mass": 41845.0, "monoisotopic_mass": 41845.0 }, "refseq": {}, "gene_names": [ { "name": "ANTKMT", "type": "recommended", "evidence": [ { "id": "A0AAA9SB58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58" } ] } ], "protein_names": [ { "name": "Adenine nucleotide translocase lysine methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SB58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANTKMT", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58", "locus": { "chromosome": "25", "start_pos": 621501, "end_pos": 619145, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049482", "url": "https://www.ensembl.org/id/ENSBTAG00000049482" } ] } } ], "crossref": [ { "id": "A0AAA9SB58", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB58", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049482", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049482", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530342", "url": "https://www.ncbi.nlm.nih.gov/gene/530342", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060324", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BNU4", "url": "https://www.orthodb.org/?gene=E1BNU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13610", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13610", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13610:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13610:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SB58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNU4", "url": "https://www.uniprot.org/uniprotkb/E1BNU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNU4-1", "url": "https://www.uniprot.org/uniprotkb/E1BNU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSAVGGPGPPETAPGLGGRSGCAGRRLSRASPSQAARASAASPRGPALPPAGGPRSGTRGTGVCSNSPRLGDARYARRAVWPEPLRVAPEPATRARDPGETGRERTDRFRRLGAAIAPPLPASATRVGQARSWKELRGAGRGRRGGAVSGPGWRVRILGLSRGGSLRRDAPKPVPRSHGAGRPGRGADGAARAAAGPVGAAAGGGGLGPGRLRRVGAAAAARLPPRAAAPAGAVCRRECQAGGARVVVAARPSWEDSGPGLWGRQDCKDCVLAAHRCGLRPAVGYELNPWLVGLARLRAWRAGCAGSVRYHREDLWKVSLRDCHNVSVFLAPSVLPLLEDKLQAELPAGARVVSGRFPLPTWQPVAVVGEGLDRVWAYDIHRGGPAGQAVPGPSSASVLGTPNSQNG", "length": 408, "header": "tr|A0AAA9SB58-1|A0AAA9SB58_BOVIN Isoform 1 of Adenine nucleotide translocase lysine methyltransferase OS=Bos taurus OX=9913 GN=ANTKMT PE=3 SV=2 CANONICAL=A0AAA9SB58-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58/entry#A0AAA9SB58-1", "sequence": { "sequence": "MPSAVGGPGPPETAPGLGGRSGCAGRRLSRASPSQAARASAASPRGPALPPAGGPRSGTRGTGVCSNSPRLGDARYARRAVWPEPLRVAPEPATRARDPGETGRERTDRFRRLGAAIAPPLPASATRVGQARSWKELRGAGRGRRGGAVSGPGWRVRILGLSRGGSLRRDAPKPVPRSHGAGRPGRGADGAARAAAGPVGAAAGGGGLGPGRLRRVGAAAAARLPPRAAAPAGAVCRRECQAGGARVVVAARPSWEDSGPGLWGRQDCKDCVLAAHRCGLRPAVGYELNPWLVGLARLRAWRAGCAGSVRYHREDLWKVSLRDCHNVSVFLAPSVLPLLEDKLQAELPAGARVVSGRFPLPTWQPVAVVGEGLDRVWAYDIHRGGPAGQAVPGPSSASVLGTPNSQNG", "length": 408, "header": "tr|A0AAA9SB58-1|A0AAA9SB58_BOVIN Isoform 1 of Adenine nucleotide translocase lysine methyltransferase OS=Bos taurus OX=9913 GN=ANTKMT PE=3 SV=2 CANONICAL=A0AAA9SB58-1" }, "locus": { "chromosome": "25", "start_pos": 620982, "end_pos": 619147, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113905.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113905.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079420.1" } ] } }, { "isoform_ac": "A0AAA9SSB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58/entry#A0AAA9SSB0-1", "sequence": { "sequence": "MEQDDPAEALTELRERRPGPLELLQVAAGSGLAVYAVWALLLQPGFRRVPLRLQVPYVGASARQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRPAVGYELNPWLVGLARLRAWRAGCAGSVRYHREDLWKLPLLEDKLQAELPAGARVVSGRFPLPTWQPVAVVGEGLDRVWAYDIHRGGPAGQAVPGPSSASVLGTPNSQNG", "length": 209, "header": "tr|A0AAA9SSB0-1|A0AAA9SSB0_BOVIN Computationally mapped isoform of Adenine nucleotide translocase lysine methyltransferase OS=Bos taurus OX=9913 GN=ANTKMT PE=3 SV=1 CANONICAL=A0AAA9SB58-1" }, "locus": { "chromosome": "25", "start_pos": 620982, "end_pos": 619682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113578.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113578.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085903.1" } ] } }, { "isoform_ac": "E1BNU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58/entry#E1BNU4-1", "sequence": { "sequence": "MEQDDPAEALTELRERRPGPLELLQVAAGSGLAVYAVWALLLQPGFRRVPLRLQVPYVGASARQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRPAVGYELNPWLVGLARLRAWRAGCAGSVRYHREDLWKVSLRDCHNVSVFLAPSVVGLGFADFMGRPGHPV", "length": 169, "header": "tr|E1BNU4-1|E1BNU4_BOVIN Computationally mapped isoform of Adenine nucleotide translocase lysine methyltransferase OS=Bos taurus OX=9913 GN=ANTKMT PE=3 SV=2 CANONICAL=A0AAA9SB58-1" }, "locus": { "chromosome": "25", "start_pos": 620686, "end_pos": 619682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074975.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074975.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064081.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064081.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58" } ], "pmid": "" }, { "name": "regulation of mitochondrial ATP synthesis coupled proton transport", "id": "GO:1905706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905706", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-lysine N-methyltransferase activity", "id": "GO:0016279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016279", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 326, "end_pos": 328 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB62-1", "uniprot_ac": "A0AAA9SB62", "uniprot_id": "A0AAA9SB62_BOVIN", "mass": { "chemical_mass": 52409.0, "monoisotopic_mass": 52409.0 }, "refseq": { "ac": "XP_024840576", "name": "carbohydrate sulfotransferase 12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840576" }, "gene_names": [ { "name": "CHST12", "type": "recommended", "evidence": [ { "id": "A0AAA9SB62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ] }, { "name": "CHST12", "type": "synonym", "evidence": [ { "id": "XP_024840576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840576" } ] } ], "protein_names": [ { "name": "Carbohydrate sulfotransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SB62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "A0AAA9SB62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62/entry#names_and_taxonomy" } ] }, { "name": "carbohydrate sulfotransferase 12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024840576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840576" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62", "locus": { "chromosome": "25", "start_pos": 40821646, "end_pos": 40846455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020898", "url": "https://www.ensembl.org/id/ENSBTAG00000020898" } ] } } ], "crossref": [ { "id": "A0AAA9SB62", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB62", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020898", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513030", "url": "https://www.ncbi.nlm.nih.gov/gene/513030", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VPMLKMY", "url": "https://omabrowser.org/oma/group/VPMLKMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0AAF6DM19", "url": "https://www.orthodb.org/?gene=A0AAF6DM19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840576", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840576", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM19", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGVSDSCFLRARRPVSTRSRSERAQGKAWASMDTMTKSRLFRLWLVLGSAFMVLLIIVYWDNMGPAHFNLHTALSRPHALKPFPSPNSASGDVFTSSLEILESFVREKQGPLLSKRVEQPSLPASSKPVLGNLEESVRGYDWSSHAAQQSADPDARQAERRSVLRGFCANDSFVFPTKERSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSQSLSDQGTPYRDPLDIPREYVHNSSTHLTFNKFWRRYGKFSRHLMKIKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYQKFAVPMLKRYSNHTSLPASVSEAFSTGLRLSFATFIQYLLDPHTEQLAPFNEHWRQVHRLCHPCQIDYDFVGKLETLDQDAAQLLRLLKVDKLLQFPPSYRNRTASSWEEGWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 451, "header": "tr|A0AAA9SB62-1|A0AAA9SB62_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST12 PE=3 SV=1 CANONICAL=A0AAA9SB62-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62/entry#A0AAA9SB62-1", "sequence": { "sequence": "MVGVSDSCFLRARRPVSTRSRSERAQGKAWASMDTMTKSRLFRLWLVLGSAFMVLLIIVYWDNMGPAHFNLHTALSRPHALKPFPSPNSASGDVFTSSLEILESFVREKQGPLLSKRVEQPSLPASSKPVLGNLEESVRGYDWSSHAAQQSADPDARQAERRSVLRGFCANDSFVFPTKERSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSQSLSDQGTPYRDPLDIPREYVHNSSTHLTFNKFWRRYGKFSRHLMKIKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYQKFAVPMLKRYSNHTSLPASVSEAFSTGLRLSFATFIQYLLDPHTEQLAPFNEHWRQVHRLCHPCQIDYDFVGKLETLDQDAAQLLRLLKVDKLLQFPPSYRNRTASSWEEGWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 451, "header": "tr|A0AAA9SB62-1|A0AAA9SB62_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST12 PE=3 SV=1 CANONICAL=A0AAA9SB62-1" }, "locus": { "chromosome": "25", "start_pos": 40831229, "end_pos": 40822754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118532.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118532.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083334.1" } ] } }, { "isoform_ac": "A0AAF6DM19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62/entry#A0AAF6DM19-1", "sequence": { "sequence": "MDTMTKSRLFRLWLVLGSAFMVLLIIVYWDNMGPAHFNLHTALSRPHALKPFPSPNSASGDVFTSSLEILESFVREKQGPLLSKRVEQPSLPASSKPVLGNLEESVRGYDWSSHAAQQSADPDARQAERRSVLRGFCANDSFVFPTKERSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSQSLSDQGTPYRDPLDIPREYVHNSSTHLTFNKFWRRYGKFSRHLMKIKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYQKFAVPMLKRYSNHTSLPASVSEAFSTGLRLSFATFIQYLLDPHTEQLAPFNEHWRQVHRLCHPCQIDYDFVGKLETLDQDAAQLLRLLKVDKLLQFPPSYRNRTASSWEEGWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 419, "header": "tr|A0AAF6DM19-1|A0AAF6DM19_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST12 PE=3 SV=1 CANONICAL=A0AAA9SB62-1" }, "locus": { "chromosome": "25", "start_pos": 40824010, "end_pos": 40822754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027841.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027841.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027841.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027841.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QL27-1", "protein_name": "Carbohydrate sulfotransferase", "gene_name": "chst12a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALSQSKSTKMGKSRLFRIFMIVGAVFMILLIIIYWDDVGASNFYLHTTISGPHPSRLSPQGRRGPEKKVEEDKESSFLTDIDAFVNQFLEGTADPTEQVRGEPPPGDPHNQSSEKSDEKFVPRREWKIHLSPIDPEKKQKQENRKQLIQDVCGNKSVFDFPGKNRTFDDIPNKELDHLIVDDRHGIIYCYVPKVACTNWKRIMIVLSESLLVDGVPYQDPLDVPQELIHNSSLHFTFNKFWKRYGKFSRHLMKIKLKKYTKFLFVRDPFVRLISAYRNKFEQENEDFYKRFALVMLKKYSNYTDPPASVVDAFAAGIRPSFSNFVQYLLDPSTEKEMPFNEHWRQMYRLCHPCQINYDFVGKLETLDEDAEHLLRILRVDNIVEFPESHRNRTVSSWEQDWFANIPLETRKELYRLYEADFKLFGYSKPEKLLHE", "length": 436 }, "evidence": [ { "id": "A0AAA9SB62", "url": "https://omabrowser.org/oma/group/A0AAA9SB62/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3GVF2-1", "protein_name": "Carbohydrate sulfotransferase", "gene_name": "Chst12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTKPRLFRLWLVLGSALMILLIIVYWDNVGTAHFYLHTSLSRPHILEPLPTPGLGGENVFTSDVDEFLDTLLSSDAKQNDLSRRKTEQPPVLAPSKPVLSHMEENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCANASLAFPTKDRTFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNSSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 419 }, "evidence": [ { "id": "A0AAA9SB62", "url": "https://omabrowser.org/oma/group/A0AAA9SB62/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q498S0-1", "protein_name": "Carbohydrate sulfotransferase", "gene_name": "Chst12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKPRLFRLWLALGSALMILLIIVYWDNVGTAHFYLHTSLSRPHILEPLPTQGLAEENVLASDVDEFLDTLLSSDAKHNDLSRRKTEQPPVLTPSKPVLSHMEENVRGYDWSTHDAQQNPDRDRQQAERRSLLRDFCANASLAFPTKDRSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNTSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRSLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 419 }, "evidence": [ { "id": "A0AAA9SB62", "url": "https://omabrowser.org/oma/group/A0AAA9SB62/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99LL3-1", "protein_name": "Carbohydrate sulfotransferase 12", "gene_name": "Chst12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKPRLFRLWLVLGSALMILLIIVYWDNVGTAHFYLHTSLSRPHILEPLPTQGLVEENVFTSDVDEFLDTLLSSDAKHNDLSRRKTEQPPVPAPSKPVLSHMEENVRGYDWSTHDAHQNPDRDRQQAERRSLLRDFCANASLAFPTKDRSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNTSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRFLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 419 }, "evidence": [ { "id": "A0AAA9SB62", "url": "https://omabrowser.org/oma/group/A0AAA9SB62/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NRB3-1", "protein_name": "Carbohydrate sulfotransferase 12", "gene_name": "CHST12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTKARLFRLWLVLGSVFMILLIIVYWDSAGAAHFYLHTSFSRPHTGPPLPTPGPDRDRELTADSDVDEFLDKFLSAGVKQSDLPRKETEQPPAPGSMEESVRGYDWSPRDARRSPDQGRQQAERRSVLRGFCANSSLAFPTKERAFDDIPNSELSHLIVDDRHGAIYCYVPKVACTNWKRVMIVLSGSLLHRGAPYRDPLRIPREHVHNASAHLTFNKFWRRYGKLSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASAREAFRAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLQLLQVDRQLRFPPSYRNRTASSWEEDWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD", "length": 414 }, "evidence": [ { "id": "A0AAA9SB62", "url": "https://omabrowser.org/oma/group/A0AAA9SB62/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "carbohydrate biosynthetic process", "id": "GO:0016051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "pmid": "" }, { "name": "chondroitin sulfate proteoglycan biosynthetic process", "id": "GO:0050650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "pmid": "" }, { "name": "dermatan sulfate proteoglycan biosynthetic process", "id": "GO:0050651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050651", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chondroitin 4-sulfotransferase activity", "id": "GO:0047756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "pmid": "" }, { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 246, "end_pos": 248 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 407, "end_pos": 409 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB67-1", "uniprot_ac": "A0AAA9SB67", "uniprot_id": "A0AAA9SB67_BOVIN", "mass": { "chemical_mass": 37882.0, "monoisotopic_mass": 37882.0 }, "refseq": { "ac": "XP_002697739", "name": "CD226 antigen", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697739" }, "gene_names": [ { "name": "CD226", "type": "recommended", "evidence": [ { "id": "A0AAA9SB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ] }, { "name": "CD226", "type": "synonym", "evidence": [ { "id": "XP_002697739", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697739" } ] } ], "protein_names": [ { "name": "CD226 antigen", "type": "synonym", "evidence": [ { "id": "XP_002697739", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697739" } ] }, { "name": "CD226 molecule", "type": "synonym", "evidence": [ { "id": "A0AAA9SB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD226", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67", "locus": { "chromosome": "24", "start_pos": 7412272, "end_pos": 7296283, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009266", "url": "https://www.ensembl.org/id/ENSBTAG00000009266" } ] } } ], "crossref": [ { "id": "A0AAA9SB67", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB67", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009266", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009266", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615496", "url": "https://www.ncbi.nlm.nih.gov/gene/615496", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615496", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615496", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BI17", "url": "https://www.orthodb.org/?gene=E1BI17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47011:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47011:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697739", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697739", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI17", "url": "https://www.uniprot.org/uniprotkb/E1BI17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI17-1", "url": "https://www.uniprot.org/uniprotkb/E1BI17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDHLTLLLAILYVYTAPCEEIFWDTTVKLAKNMTLECVYPLADTVTQMEWFKIKMERESMAIFNPAFHGIIREAYTDRVYFSNHTMASNDMTLSFHNASEADVGFYSCLLHTFPHGTWEKVIQVVPPDNFEDAGPPNSQMVSEPGKNITLTCEPRENHLLEEVSWEKIQPQQIDLLISCNLSQGRNYTSKYPRQILSNCNKGMKKAFVTMPNVIGSDSGLYRCGFKASTGEKETFVMRLTVTNGETKNSYIPFVAGGAVLLFLLVILITTITVITYKRKKRQQKRGLFKDVWITQNRATNNYRNPFPPNPPAGGAGEDIYVNHPVFCLGPRARV", "length": 334, "header": "tr|A0AAA9SB67-1|A0AAA9SB67_BOVIN Isoform 1 of CD226 molecule OS=Bos taurus OX=9913 GN=CD226 PE=4 SV=1 CANONICAL=A0AAA9SB67-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67/entry#A0AAA9SB67-1", "sequence": { "sequence": "MDHLTLLLAILYVYTAPCEEIFWDTTVKLAKNMTLECVYPLADTVTQMEWFKIKMERESMAIFNPAFHGIIREAYTDRVYFSNHTMASNDMTLSFHNASEADVGFYSCLLHTFPHGTWEKVIQVVPPDNFEDAGPPNSQMVSEPGKNITLTCEPRENHLLEEVSWEKIQPQQIDLLISCNLSQGRNYTSKYPRQILSNCNKGMKKAFVTMPNVIGSDSGLYRCGFKASTGEKETFVMRLTVTNGETKNSYIPFVAGGAVLLFLLVILITTITVITYKRKKRQQKRGLFKDVWITQNRATNNYRNPFPPNPPAGGAGEDIYVNHPVFCLGPRARV", "length": 334, "header": "tr|A0AAA9SB67-1|A0AAA9SB67_BOVIN Isoform 1 of CD226 molecule OS=Bos taurus OX=9913 GN=CD226 PE=4 SV=1 CANONICAL=A0AAA9SB67-1" }, "locus": { "chromosome": "24", "start_pos": 7383640, "end_pos": 7301497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097327.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097327.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080710.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080710.1" } ] } }, { "isoform_ac": "A0AAA9TFJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67/entry#A0AAA9TFJ2-1", "sequence": { "sequence": "MDHLTLLLAILYVYTAPCEEIFWDTTVKLAKNMTLECVYPLADTVTQMEWFKIKMERESMAIFNPAFHGIIREAYTDRVYFSNHTMASNDMTLSFHNASEADVGFYSCLLHTFPHGTWEKVIQVVPPDNFEDAGPPNSQMVSEPGKNITLTCEPRENHLLEEVSWEKIQPQQIDLLISCNLSQGRNYTSKYPRQILSNCNKGMKKAFVTMPNVIGSDSGLYRCGFKASTGEKETFVMRLTVTNGETKNSYIPFVAGGAVLLFLLVILITTITVITYKRKKRQQKRGLFKDVWITQNRVLSLLMHLASEGCRLL", "length": 313, "header": "tr|A0AAA9TFJ2-1|A0AAA9TFJ2_BOVIN Computationally mapped isoform of CD226 molecule OS=Bos taurus OX=9913 GN=CD226 PE=4 SV=1 CANONICAL=A0AAA9SB67-1" }, "locus": { "chromosome": "24", "start_pos": 7411501, "end_pos": 7301497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090969.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090969.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096914.1" } ] } }, { "isoform_ac": "E1BI17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67/entry#E1BI17-1", "sequence": { "sequence": "MDHLTLLLAILYVYTAPCEEIFWDTTVKLAKNMTLECVYPLADTVTQMEWFKIKMERESMAIFNPAFHGIIREAYTDRVYFSNHTMASNDMTLSFHNASEADVGFYSCLLHTFPHGTWEKVIQVVPPDNFEDAGPPNSQMVSEPGKNITLTCEPRENHLLEEVSWEKIQPQQIDLLISCNLSQGRNYTSKYPRQILSNCNKGMKKAFVTMPNVIGSDSGLYRCGFKASTGEKETFVMRLTVTNERKGNRKEAYLKTSGSHRIGQPTTTEIPSLPIHRQVVQERTFMSTTRSSVLDQGLESKPIIGECK", "length": 308, "header": "tr|E1BI17-1|A0AAA9SB67_BOVIN Computationally mapped isoform of CD226 molecule OS=Bos taurus OX=9913 GN=CD226 PE=4 SV=3 CANONICAL=A0AAA9SB67-1" }, "locus": { "chromosome": "24", "start_pos": 7383665, "end_pos": 7301497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012208.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012208.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012208.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012208.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615496", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of T cell receptor signaling pathway", "id": "GO:0050862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050862", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell cytokine production", "id": "GO:0002729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target", "id": "GO:0002860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002860", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "positive regulation of immunoglobulin mediated immune response", "id": "GO:0002891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "positive regulation of mast cell activation", "id": "GO:0033005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" }, { "name": "positive regulation of Fc receptor mediated stimulatory signaling pathway", "id": "GO:0060369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060369", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB67" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 108, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 186, "end_pos": 188 }, { "start_pos": 32, "end_pos": 34 }, { "start_pos": 83, "end_pos": 85 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB84-1", "uniprot_ac": "A0AAA9SB84", "uniprot_id": "A0AAA9SB84_BOVIN", "mass": { "chemical_mass": 71646.0, "monoisotopic_mass": 71646.0 }, "refseq": { "ac": "XP_005226082", "name": "cationic amino acid transporter 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226082" }, "gene_names": [ { "name": "SLC7A2", "type": "recommended", "evidence": [ { "id": "A0AAA9SB84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ] }, { "name": "SLC7A2", "type": "synonym", "evidence": [ { "id": "XP_005226082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226082" } ] } ], "protein_names": [ { "name": "Cationic amino acid transporter 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SB84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84/entry#names_and_taxonomy" } ] }, { "name": "Low affinity cationic amino acid transporter 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SB84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 7 member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SB84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84/entry#names_and_taxonomy" } ] }, { "name": "cationic amino acid transporter 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005226082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226082" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC7A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84", "locus": { "chromosome": "27", "start_pos": 19714928, "end_pos": 19786832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010085", "url": "https://www.ensembl.org/id/ENSBTAG00000010085" } ] } } ], "crossref": [ { "id": "A0AAA9SB84", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB84", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010085", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010085", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538708", "url": "https://www.ncbi.nlm.nih.gov/gene/538708", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538708", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538708", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRVWFSM", "url": "https://omabrowser.org/oma/group/TRVWFSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MF81", "url": "https://www.orthodb.org/?gene=A0A3Q1MF81", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B968", "url": "https://www.orthodb.org/?gene=E1B968", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF94", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF94", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005226082", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226082", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "32143", "url": "https://www.rhea-db.org/rhea/32143", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70935", "url": "https://www.rhea-db.org/rhea/70935", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71199", "url": "https://www.rhea-db.org/rhea/71199", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71203", "url": "https://www.rhea-db.org/rhea/71203", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MF81", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF81-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B968", "url": "https://www.uniprot.org/uniprotkb/E1B968", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B968-1", "url": "https://www.uniprot.org/uniprotkb/E1B968-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIPCRAALSFARCLVRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFFRTYFKMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEDFLKNISASARDPPSENGTSVYGAGGFMPYGFAGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAVMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPGLSYEQPKYCSEKEALGSCANRTSKSKSQVTMLPGQGFSLRTLFNPSLLPTKQSASLVSFLVGFLAFLILGLSVLTTHSVHTIARLEAWSLALLVLFLALCVAIVLIIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSVWMALGFLIYFAYGIRHSLEGTPRDEEDDDEDMYSDNINAATEEKSAMQDGDHHQRNLSLPFIFHEKTSEC", "length": 659, "header": "tr|A0AAA9SB84-1|A0AAA9SB84_BOVIN Isoform 1 of Cationic amino acid transporter 2 OS=Bos taurus OX=9913 GN=SLC7A2 PE=3 SV=1 CANONICAL=A0AAA9SB84-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MF81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84/entry#A0A3Q1MF81-1", "sequence": { "sequence": "MIPCRAALSFARCLVRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFFRTYFKMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEDFLKNISASARDPPSENGTSVYGAGGFMPYGFAGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAVMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPGLSYEQPKYCSEKEALGSCANRTSKSKSQVTMLPGQGFSLRTLFNPSLLPTKQSASLVSFLVGFLAFLILGLSVLTTHSVHTIARLEAWSLALLVLFLALCVAIVLIIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSVWMALAPNIP", "length": 598, "header": "tr|A0A3Q1MF81-1|A0A3Q1MF81_BOVIN Computationally mapped isoform of Cationic amino acid transporter 2 OS=Bos taurus OX=9913 GN=SLC7A2 PE=3 SV=2 CANONICAL=A0AAA9SB84-1" }, "locus": { "chromosome": "27", "start_pos": 19744874, "end_pos": 19715472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075823.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075823.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069189.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069189.2" } ] } }, { "isoform_ac": "A0AAA9SB84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84/entry#A0AAA9SB84-1", "sequence": { "sequence": "MIPCRAALSFARCLVRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFFRTYFKMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEDFLKNISASARDPPSENGTSVYGAGGFMPYGFAGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAVMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPGLSYEQPKYCSEKEALGSCANRTSKSKSQVTMLPGQGFSLRTLFNPSLLPTKQSASLVSFLVGFLAFLILGLSVLTTHSVHTIARLEAWSLALLVLFLALCVAIVLIIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSVWMALGFLIYFAYGIRHSLEGTPRDEEDDDEDMYSDNINAATEEKSAMQDGDHHQRNLSLPFIFHEKTSEC", "length": 659, "header": "tr|A0AAA9SB84-1|A0AAA9SB84_BOVIN Isoform 1 of Cationic amino acid transporter 2 OS=Bos taurus OX=9913 GN=SLC7A2 PE=3 SV=1 CANONICAL=A0AAA9SB84-1" }, "locus": { "chromosome": "27", "start_pos": 19744874, "end_pos": 19719911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095174.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095174.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083354.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083354.1" } ] } }, { "isoform_ac": "E1B968-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84/entry#E1B968-1", "sequence": { "sequence": "MIPCRAALSFARCLVRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFFRTYFKMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEDFLKNISASARDPPSENGTSVYGAGGFMPYGFAGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATLTAGVISAVMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPGLSYEQPKYCSEKEALGSCANRTSKSKSQVTMLPGQGFSLRTLFNPSLLPTKQSASLVSFLVGFLAFLILGLSVLTTHSVHTIARLEAWSLALLVLFLALCVAIVLIIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSVWMALGFLIYFAYGIRHSLEGTPRDEEDDDEDMYSDNINAATEEKSAMQDGDHHQRNLSLPFIFHEKTSEC", "length": 658, "header": "tr|E1B968-1|E1B968_BOVIN Computationally mapped isoform of Cationic amino acid transporter 2 OS=Bos taurus OX=9913 GN=SLC7A2 PE=3 SV=4 CANONICAL=A0AAA9SB84-1" }, "locus": { "chromosome": "27", "start_pos": 19744874, "end_pos": 19719911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013304.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013304.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013304.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013304.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 106, "start_aa": "Thr", "end_pos": 106, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr106", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538708", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538708", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BGS3-1", "protein_name": "Cationic amino acid transporter 2", "gene_name": "SLC7A2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIPCRATLSFARCLIRRKVVTLDSLEDSKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFRTYFKMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPVIATLSSGAVAAVMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPGLSYEQPKYCPEKEALGSCASAASKSKSQVTVLPERGFSLRAFFSPSLLPTKQSASLVSFLVGFLAFLILGLSILTTYGVHAIARLEAWSLALLVLFLVLCVAVVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSIWMALGFLIYFAYGIRHSLEGNSRDEDEDEDTHSNNVHTAAEEKSAIQANDHHQRHLSLPFIFHEKTSEC", "length": 658 }, "evidence": [ { "id": "A0AAA9SB84", "url": "https://omabrowser.org/oma/group/A0AAA9SB84/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B5D5N9-1", "protein_name": "Cationic amino acid transporter 2", "gene_name": "Slc7a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIPCRAVLTFTRCLIRRKIVTLDSLEDSKLCRCLTTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYEQPKYTPEKDILESCTNATSKSESQVTMLQGQGFSLRTLFNPSALPTRQSASLVSFLVGFLAFLIAGLSILTTYGVQAIARLEAWSLALLALFLVLCAAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMVLGFLIYFAYGIRHSLEGNPRDEEEDEDVCPDNVNAAAEEKSAMQANDHHQRNLSLPFILHEKTSEC", "length": 657 }, "evidence": [ { "id": "A0AAA9SB84", "url": "https://omabrowser.org/oma/group/A0AAA9SB84/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P18581-1", "protein_name": "Cationic amino acid transporter 2", "gene_name": "Slc7a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIPCRAVLTFARCLIRRKIVTLDSLEDSKLCRCLTTVDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVRWSPAKYVVSAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYDQPKYTPEKETLESCTNATLKSESQVTMLQGQGFSLRTLFSPSALPTRQSASLVSFLVGFLAFLILGLSILTTYGVQAIARLEAWSLALLALFLVLCVAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSIWMALGFLIYFAYGIRHSLEGNPRDEEDDEDAFSDNINAATEEKSAMQANDHHQRNLSLPFILHEKTSEC", "length": 657 }, "evidence": [ { "id": "A0AAA9SB84", "url": "https://omabrowser.org/oma/group/A0AAA9SB84/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P52569-1", "protein_name": "Cationic amino acid transporter 2", "gene_name": "SLC7A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF", "length": 658 }, "evidence": [ { "id": "A0AAA9SB84", "url": "https://omabrowser.org/oma/group/A0AAA9SB84/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8W4K3-1", "protein_name": "Cationic amino acid transporter 4, vacuolar", "gene_name": "CAT4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNSLVRRKQVDSVHLIKNDGPHQLAKKLSAVDLVAIGVGTTIGAGVYILVGTVAREHTGPALAVSFFIAGVAAALSACCYAELASRCPSAGSAYHYAYICLGEGIAWLVGWALVLDYTIGGSAIARGITPNLASFFGGLDNLPVFLARQTIPGVGIVVDPCAALLIMIVTILLCFGIKESSTVQAIVTSVNVCTLVFIIVVGGYLACKTGWVGYDLPSGYFPFGLNGILAGSAVVFFSYIGFDTVTSTAEEVKNPQRDLPLGIGIALLICCILYMLLSVVIVGLVPYYSLNPDTPISSAFGDSGMQWAAYILTTGAITALCASLLGSLLAQPRIFMAMARDGLLPAFFSEISPRTQVPVKSTIAIGVLAAALAFFMDVAQLSEMVSVGTLMAFTAVAVCVLVLRYVPPDGVPLSSSSQTLSDTDESRAETENFLVDAIESSDSPLLGNETARDEKYFGKRRKIAAWSIALVCIGVLGLASAASAERLPSFPRFTICGVSAVILLGSLITLGYIDEDEERHNFGHKGGFLCPFVPYLPVLCILINTYLIINIGAGTWIRVLIWLLIGSMIYIFYGRSHSLLNNAVYVPTMTCTRKTTDHLA", "length": 600 }, "evidence": [ { "id": "A0AAA9SB84", "url": "https://omabrowser.org/oma/group/A0AAA9SB84/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VVM0-1", "protein_name": "Cationic amino acid transporter C-terminal domain-containing protein", "gene_name": "anon-WO0118547.111", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEEFAEYYGMPSWSVTNAFRVLTRKKPLEDSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQLCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLAIFLAYGIRHSRLRQREQRNNSIAMMRDCSNSALLGGQENSKYSNEVPLILMHSTS", "length": 630 }, "evidence": [ { "id": "A0AAA9SB84", "url": "https://omabrowser.org/oma/group/A0AAA9SB84/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "L-arginine transmembrane transporter activity", "id": "GO:0061459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" }, { "name": "L-ornithine transmembrane transporter activity", "id": "GO:0000064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" }, { "name": "L-lysine transmembrane transporter activity", "id": "GO:0015189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "L-arginine import across plasma membrane", "id": "GO:0097638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097638", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" }, { "name": "L-ornithine transmembrane transport", "id": "GO:1903352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 645, "end_pos": 647, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32143", "name": "", "equation": "L-arginine(in) = L-arginine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "32143", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32143" } ] }, { "id": "70935", "name": "", "equation": "L-lysine(in) = L-lysine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "70935", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70935" } ] }, { "id": "71199", "name": "", "equation": "L-ornithine(in) = L-ornithine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71199", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71199" } ] }, { "id": "71203", "name": "", "equation": "L-homoarginine(in) = L-homoarginine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71203", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71203" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SB84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB84" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 556, "end_pos": 606, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 106 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 227, "end_pos": 229 }, { "start_pos": 239, "end_pos": 241 }, { "start_pos": 457, "end_pos": 459 }, { "start_pos": 645, "end_pos": 647 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBB2-1", "uniprot_ac": "A0AAA9SBB2", "uniprot_id": "A0AAA9SBB2_BOVIN", "mass": { "chemical_mass": 81490.0, "monoisotopic_mass": 81490.0 }, "refseq": { "ac": "XP_015328959", "name": "coiled-coil domain-containing protein 138 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328959" }, "gene_names": [ { "name": "CCDC138", "type": "recommended", "evidence": [ { "id": "A0AAA9SBB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2" } ] }, { "name": "CCDC138", "type": "synonym", "evidence": [ { "id": "XP_015328959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328959" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 138", "type": "synonym", "evidence": [ { "id": "A0AAA9SBB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 138 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015328959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328959" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC138", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2", "locus": { "chromosome": "11", "start_pos": 44616607, "end_pos": 44646081, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000157", "url": "https://www.ensembl.org/id/ENSBTAG00000000157" } ] } } ], "crossref": [ { "id": "A0AAA9SBB2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000157", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000157", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507644", "url": "https://www.ncbi.nlm.nih.gov/gene/507644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507644", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507644", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BJX9", "url": "https://www.orthodb.org/?gene=E1BJX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34523:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34523:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015328959", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJX9", "url": "https://www.uniprot.org/uniprotkb/E1BJX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJX9-1", "url": "https://www.uniprot.org/uniprotkb/E1BJX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAPPRVRGLFPKKHESASLPGAGHVVRHGAYSPHSPAPPRAVARETTSVAAMEPRVVKPPGQDLVVERLKSRYGLAGGCLSEPGRRRQDVAERRRRPPRTPEDLDIFCCGDKVGPSLRCFSDERRRRPTSPRGVLTVNWQDDELDSFQDLKEPETEEEFTGNDSRVSTSKINRQSFKETDKANAWPANVASRSKSWADYCSDGSDSPSKHIGWPASRAPRKPGLLPRQVSQIYDELLQIHQKLQCETAAQQEFAEELQKRERFLVEREELLFRHEGALSEVKDVREEVLMRFQIMKEQHDAEVEHLTEVLRERNKESKRLRSSFDALKGLNDSLKKQLNEVSEENRKLEVQAKRVQARLDNLQRKYEFMTIQRLKGNPQATHEAKSLKQEKVPASKPCKVSLNGQVYELLTVFMDWISDHHLSKLKNEESGMDGEKPLPTFGSQRSDIQEKCVKLLPLMTEQLQWLPFVNARLHEPFVKFIYWSLRQLDAGTQHSTMTATLRRLGEDIFRGVVTKGVQDVALEHSVESRPRTAAFFKSTSLPLRFVSTLIVLKTVTQADFLAQAFDSLCLDLQADEGKSLFLQLQAVPVVLSHLKLSSRGLLPSVMDSLLQMTVESSALQPFLEACSCSLFFRTCSVLLRAPKLDLHVLEKLSIILQKLSKIKSNKKLFELFTIHLMLQEIQRTTHPEHAFLCINLNSTLFNLGLTKCSSLATSTNP", "length": 718, "header": "tr|A0AAA9SBB2-1|A0AAA9SBB2_BOVIN Isoform 1 of Coiled-coil domain containing 138 OS=Bos taurus OX=9913 GN=CCDC138 PE=4 SV=1 CANONICAL=A0AAA9SBB2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2/entry#A0AAA9SBB2-1", "sequence": { "sequence": "MPAPPRVRGLFPKKHESASLPGAGHVVRHGAYSPHSPAPPRAVARETTSVAAMEPRVVKPPGQDLVVERLKSRYGLAGGCLSEPGRRRQDVAERRRRPPRTPEDLDIFCCGDKVGPSLRCFSDERRRRPTSPRGVLTVNWQDDELDSFQDLKEPETEEEFTGNDSRVSTSKINRQSFKETDKANAWPANVASRSKSWADYCSDGSDSPSKHIGWPASRAPRKPGLLPRQVSQIYDELLQIHQKLQCETAAQQEFAEELQKRERFLVEREELLFRHEGALSEVKDVREEVLMRFQIMKEQHDAEVEHLTEVLRERNKESKRLRSSFDALKGLNDSLKKQLNEVSEENRKLEVQAKRVQARLDNLQRKYEFMTIQRLKGNPQATHEAKSLKQEKVPASKPCKVSLNGQVYELLTVFMDWISDHHLSKLKNEESGMDGEKPLPTFGSQRSDIQEKCVKLLPLMTEQLQWLPFVNARLHEPFVKFIYWSLRQLDAGTQHSTMTATLRRLGEDIFRGVVTKGVQDVALEHSVESRPRTAAFFKSTSLPLRFVSTLIVLKTVTQADFLAQAFDSLCLDLQADEGKSLFLQLQAVPVVLSHLKLSSRGLLPSVMDSLLQMTVESSALQPFLEACSCSLFFRTCSVLLRAPKLDLHVLEKLSIILQKLSKIKSNKKLFELFTIHLMLQEIQRTTHPEHAFLCINLNSTLFNLGLTKCSSLATSTNP", "length": 718, "header": "tr|A0AAA9SBB2-1|A0AAA9SBB2_BOVIN Isoform 1 of Coiled-coil domain containing 138 OS=Bos taurus OX=9913 GN=CCDC138 PE=4 SV=1 CANONICAL=A0AAA9SBB2-1" }, "locus": { "chromosome": "11", "start_pos": 44645882, "end_pos": 44616972, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079484.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079484.1" } ] } }, { "isoform_ac": "A0AAA9TBD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2/entry#A0AAA9TBD4-1", "sequence": { "sequence": "MEPRVVKPPGQDLVVERLKSRYGLAGGCLSEPGRRRQDVAERRRRPPRTPEDLDIFCCGDKVGPSLRCFSDERRRRPTSPRGVLTVNWQDDELDSFQDLKEPETEEEFTGNDSRVSTSKINRQSFKETDKANAWPANVASRSKSWADYCSDGSDSPSKHIGWPASRAPRKPGLLPRQVSQIYDELLQIHQKLQCETAAQQEFAEELQKRERFLVEREELLFRHEGALSEVKDVREEVLMRFQIMKELNEVSEENRKLEVQAKRVQARLDNLQRKYEFMTIQRLKGNPQATHEAKSLKQEKVPASKPCKVSLNGQVYELLTVFMDWISDHHLSKLKNEESGMDGEKPLPTFGSQRSDIQEKCVKLLPLMTEQLQWLPFVNARLHEPFVKFIYWSLRQLDAGTQHSTMTATLRRLGEDIFRGVVTKGVQDVALEHSVESRPRTAAFFKSTSLPLRFVSTLIVLKTVTQADFLAQAFDSLCLDLQADEGKSLFLQLQAVPVVLSHLKLSSRGLLPSVMDSLLQMTVESSALQPFLEACSCSLFFRTCSVLLRAPKLDLHVLEKLSIILQKLSKIKSNKKLFELFTIHLMLQEIQRTTHPEHAFLCINLNSTLFNLGLTKCSSLATSTNP", "length": 626, "header": "tr|A0AAA9TBD4-1|A0AAA9TBD4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 138 OS=Bos taurus OX=9913 GN=CCDC138 PE=4 SV=1 CANONICAL=A0AAA9SBB2-1" }, "locus": { "chromosome": "11", "start_pos": 44645726, "end_pos": 44616972, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093394.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093394.1" } ] } }, { "isoform_ac": "E1BJX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2/entry#E1BJX9-1", "sequence": { "sequence": "MCCWAVRGQQFCRGVFTLGKTNGSLDDELDSFQDLKEPETEEEFTGNDSRVSTSKINRQSFKETDKANAWPANVASRSKSWADYCSDGSDSPSKHIGWPASRAPRKPGLLPRQVSQIYDELLQIHQKLQCETAAQQEFAEELQKRERFLVEREELLFRHEGALSEVKDVREEVLMRFQIMKEQHDAEVEHLTEVLRERNKESKRLRSSFDALKGLNDSLKKQLNEVSEENRKLEVQAKRVQARLDNLQRKYEFMTIQRLKGNPQATHEAKSLKQEKVPASKPCKVSLNGQVYELLTVFMDWISDHHLSKLKNEESGMDGEKPLPTFGSQRSDIQEKCVKLLPLMTEQLQWLPFVNARLHEPFVKFIYWSLRQLDAGTQHSTMTATLRRLGEDIFRGVVTKGVQDVALEHSVESRPRTAAFFKSTSLPLRFVSTLIVLKTVTQADFLAQAFDSLCLDLQADEGKSLFLQLQAVPVVLSHLKLSSRGLLPSVMDSLLQMTVESSALQPFLEACSCSLFFRTCSVLLRAPKLDLHVLEKLSIILQKLSKIKSNKKLFELFTIHLMLQEIQRTTHPEHAFLCINLNSTLFNLGLTKCSSLATSTNP", "length": 602, "header": "tr|E1BJX9-1|A0AAA9SBB2_BOVIN Computationally mapped isoform of Coiled-coil domain containing 138 OS=Bos taurus OX=9913 GN=CCDC138 PE=4 SV=4 CANONICAL=A0AAA9SBB2-1" }, "locus": { "chromosome": "11", "start_pos": 44644224, "end_pos": 44616972, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000181.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000181.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000181.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000181.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507644", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507644", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2" }, { "id": "PF21035", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21035" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Coiled-coil", "eco_id": "ECO_0000259", "start_pos": 415, "end_pos": 704, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB2" }, { "id": "PF21037", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Coiled-coil-domain-containing protein 138 coiled-coil", "eco_id": "ECO_0000259", "start_pos": 316, "end_pos": 374, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 698, "end_pos": 700 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBB4-1", "uniprot_ac": "A0AAA9SBB4", "uniprot_id": "A0AAA9SBB4_BOVIN", "mass": { "chemical_mass": 24345.0, "monoisotopic_mass": 24345.0 }, "refseq": { "ac": "XP_059740635", "name": "transcription cofactor HES-6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740635" }, "gene_names": [ { "name": "HES6", "type": "recommended", "evidence": [ { "id": "A0AAA9SBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ] }, { "name": "HES6", "type": "synonym", "evidence": [ { "id": "XP_059740635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740635" } ] } ], "protein_names": [ { "name": "Transcription cofactor HES-6", "type": "recommended", "evidence": [ { "id": "A0AAA9SBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4/entry#names_and_taxonomy" } ] }, { "name": "Hairy and enhancer of split 6", "type": "synonym", "evidence": [ { "id": "A0AAA9SBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4/entry#names_and_taxonomy" } ] }, { "name": "transcription cofactor HES-6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059740635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740635" } ] } ], "function": [ { "annotation": "Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4#function" }, { "database": "UniProtKB", "id": "ARBA00055708", "url": "https://www.uniprot.org/uniprotkb/ARBA00055708#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HES6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4", "locus": { "chromosome": "3", "start_pos": 117549881, "end_pos": 117552090, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054800", "url": "https://www.ensembl.org/id/ENSBTAG00000054800" } ] } } ], "crossref": [ { "id": "A0AAA9SBB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054800", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054800", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531384", "url": "https://www.ncbi.nlm.nih.gov/gene/531384", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EDESCYG", "url": "https://omabrowser.org/oma/group/EDESCYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSS2", "url": "https://www.orthodb.org/?gene=A0A3Q1LSS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059740635", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSS2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSS2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPLLAPGRDRAGREDEDGCEARGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFRDLLGDALSAPPAAPGRSNWLVGGALESPLPSPRGSGDDQSSDLEEVPEAELSRAPPAEGTDSVPAALGSLTSARLAQSVWRPW", "length": 225, "header": "tr|A0AAA9SBB4-1|A0AAA9SBB4_BOVIN Isoform 1 of Transcription cofactor HES-6 OS=Bos taurus OX=9913 GN=HES6 PE=4 SV=1 CANONICAL=A0AAA9SBB4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4/entry#A0A3Q1LSS2-1", "sequence": { "sequence": "MAPLLAPGRDRAGREDEDGCEARGDRKVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFRDLLGDALSAPPAAPGRSNWLVGGALESPLPSPRGSGDDQSSDLEEVPEAELSRAPPAEGTDSVPAALGSLTSARLAQSVWRPW", "length": 196, "header": "tr|A0A3Q1LSS2-1|A0A3Q1LSS2_BOVIN Computationally mapped isoform of Hes family bHLH transcription factor 6 OS=Bos taurus OX=9913 GN=HES6 PE=4 SV=2 CANONICAL=A0AAA9SBB4-1" }, "locus": { "chromosome": "3", "start_pos": 117551891, "end_pos": 117550815, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068417.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068417.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060322.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060322.2" } ] } }, { "isoform_ac": "A0AAA9SBB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4/entry#A0AAA9SBB4-1", "sequence": { "sequence": "MAPLLAPGRDRAGREDEDGCEARGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFRDLLGDALSAPPAAPGRSNWLVGGALESPLPSPRGSGDDQSSDLEEVPEAELSRAPPAEGTDSVPAALGSLTSARLAQSVWRPW", "length": 225, "header": "tr|A0AAA9SBB4-1|A0AAA9SBB4_BOVIN Isoform 1 of Transcription cofactor HES-6 OS=Bos taurus OX=9913 GN=HES6 PE=4 SV=1 CANONICAL=A0AAA9SBB4-1" }, "locus": { "chromosome": "3", "start_pos": 117551891, "end_pos": 117550815, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104449.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104449.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080758.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SIU5-1", "protein_name": "Transcription cofactor HES-6", "gene_name": "HES6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPLLAPGRDRAGREDEDGCEARGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLRESSSFRDLLGDALSGPPGVHGRSNWPVGGPLGSPLPSPRGSGDDQSSDLEEAPEAELSRATVEGPELVPVALGSLTAAHMAHSVWRPW", "length": 224 }, "evidence": [ { "id": "A0AAA9SBB4", "url": "https://omabrowser.org/oma/group/A0AAA9SBB4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96HZ4-1", "protein_name": "Transcription cofactor HES-6", "gene_name": "HES6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW", "length": 224 }, "evidence": [ { "id": "A0AAA9SBB4", "url": "https://omabrowser.org/oma/group/A0AAA9SBB4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JHE6-1", "protein_name": "Transcription cofactor HES-6", "gene_name": "Hes6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPSQAPSRDRAGQEDEDRWEARGDRKARKPLVEKKRRARINESLQELRLLLAGTEVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVSAELLNHLLESMPLREGSSFQDLLGDSLAGLPGGSGRSSWPPGGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVPAEGPDLVSTSLGSLTAARRAQSVWRPW", "length": 224 }, "evidence": [ { "id": "A0AAA9SBB4", "url": "https://omabrowser.org/oma/group/A0AAA9SBB4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "transcription regulator inhibitor activity", "id": "GO:0140416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 77, "start_aa": "Asp", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB4" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 129, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBB5-1", "uniprot_ac": "A0AAA9SBB5", "uniprot_id": "A0AAA9SBB5_BOVIN", "mass": { "chemical_mass": 116162.0, "monoisotopic_mass": 116162.0 }, "refseq": { "ac": "XP_059732333", "name": "huntingtin-interacting protein 1-related protein isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732333" }, "gene_names": [ { "name": "HIP1R", "type": "recommended", "evidence": [ { "id": "A0AAA9SBB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ] }, { "name": "HIP1R", "type": "synonym", "evidence": [ { "id": "XP_059732333", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732333" } ] } ], "protein_names": [ { "name": "Huntingtin-interacting protein 1-related protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SBB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5/entry#names_and_taxonomy" } ] }, { "name": "huntingtin-interacting protein 1-related protein isoform X4", "type": "synonym", "evidence": [ { "id": "XP_059732333", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732333" } ] } ], "function": [ { "annotation": "Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TRR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR7#function" }, { "database": "UniProtKB", "id": "ARBA00059997", "url": "https://www.uniprot.org/uniprotkb/ARBA00059997#function" }, { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5#function" }, { "database": "UniProtKB", "id": "F1MUI0", "url": "https://www.uniprot.org/uniprotkb/F1MUI0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIP1R", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5", "locus": { "chromosome": "17", "start_pos": 52670416, "end_pos": 52697383, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021595", "url": "https://www.ensembl.org/id/ENSBTAG00000021595" } ] } } ], "crossref": [ { "id": "A0AAA9SBB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17014", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17014", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508291", "url": "https://www.ncbi.nlm.nih.gov/gene/508291", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MUI0", "url": "https://www.orthodb.org/?gene=F1MUI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10407", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10407", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10407:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10407:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27524", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27524", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059732333", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732333", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUI0", "url": "https://www.uniprot.org/uniprotkb/F1MUI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUI0-1", "url": "https://www.uniprot.org/uniprotkb/F1MUI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNEAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSAILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNIYTKLLLTKIAFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPAVVADLFEQTFGPPNGSMKDDRDLQIEALKREVEMLRSELDKIKLEAQRFISQLKGQVNALEAELEEQRKQKQKALVDNEQLRHELAQLRAAQVEGERNQGLREEAEKKASATEARYNKLKEKHSELVNTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLVFQVEQVKRESEMKLEEQSDQLEKLKRELEAKAGELVRVQEALSRTEQSGSELSSRLDALSADRDELSRVVQQREADLLAAQSLAREKEAALSQERQRISRERDELQGRLADKESQEQGLQQRLLDEQFAMLRATAAEAERILQDAVGKLDDPLHLRCTSSPDYLVSRAQAALDAVSALEKGHAQYLTSRADASGLVAALTRFSHLTADTIVHGSATSHLAPTDPADRLIDTCRECGARALELMGQLQEQQALLQARPGLVRTPLQGILQLGQELKPKSLDVREEELGAMVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTASTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKADKHSPHLSRLQECSRTVNEMAANVVASTKSGQEQVEDRDTMDFSGLSLIKLKKQEMETQVRALELEKTLEVERVRLGELRRQHYLLAGAVGTPGEEEPSQPSATPHSGTKKPPLAQKPTVAPRQDHQLDKKDGSYAAQVVN", "length": 1038, "header": "tr|A0AAA9SBB5-1|A0AAA9SBB5_BOVIN Isoform 1 of Huntingtin-interacting protein 1-related protein OS=Bos taurus OX=9913 GN=HIP1R PE=1 SV=1 CANONICAL=A0AAA9SBB5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5/entry#A0AAA9SBB5-1", "sequence": { "sequence": "MNEAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSAILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNIYTKLLLTKIAFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPAVVADLFEQTFGPPNGSMKDDRDLQIEALKREVEMLRSELDKIKLEAQRFISQLKGQVNALEAELEEQRKQKQKALVDNEQLRHELAQLRAAQVEGERNQGLREEAEKKASATEARYNKLKEKHSELVNTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLVFQVEQVKRESEMKLEEQSDQLEKLKRELEAKAGELVRVQEALSRTEQSGSELSSRLDALSADRDELSRVVQQREADLLAAQSLAREKEAALSQERQRISRERDELQGRLADKESQEQGLQQRLLDEQFAMLRATAAEAERILQDAVGKLDDPLHLRCTSSPDYLVSRAQAALDAVSALEKGHAQYLTSRADASGLVAALTRFSHLTADTIVHGSATSHLAPTDPADRLIDTCRECGARALELMGQLQEQQALLQARPGLVRTPLQGILQLGQELKPKSLDVREEELGAMVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTASTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKADKHSPHLSRLQECSRTVNEMAANVVASTKSGQEQVEDRDTMDFSGLSLIKLKKQEMETQVRALELEKTLEVERVRLGELRRQHYLLAGAVGTPGEEEPSQPSATPHSGTKKPPLAQKPTVAPRQDHQLDKKDGSYAAQVVN", "length": 1038, "header": "tr|A0AAA9SBB5-1|A0AAA9SBB5_BOVIN Isoform 1 of Huntingtin-interacting protein 1-related protein OS=Bos taurus OX=9913 GN=HIP1R PE=1 SV=1 CANONICAL=A0AAA9SBB5-1" }, "locus": { "chromosome": "17", "start_pos": 52692859, "end_pos": 52671420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081187.1" } ] } }, { "isoform_ac": "A0AAA9TRR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5/entry#A0AAA9TRR7-1", "sequence": { "sequence": "MNSIKNVPARVLNRRPGHSLEAEREQFDKTQASGGAAGGRAGGRRPLPFPSHTSFEPGLRPSPGRPRPLSPGRLCSPGCISVTATPAPRPPPPRAQVNRKRAPAPGPEAARGAGVAGTEMPPGTETQLRGPGGPGTGQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSAILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNIYTKLLLTKIAFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPAVVADLFEQTFGPPNGSMKDDRDLQIEALKREVEMLRSELDKIKLEAQRFISQLKGQVNALEAELEEQRKQKQKALVDNEQLRHELAQLRAAQVEGERNQGLREEAEKKASATEARYNKLKEKHSELVNTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLVFQVEQVKRESEMKLEEQSDQLEKLKRELEAKAGELVRVQEALSRTEQSGSELSSRLDALSADRDELSRVVQQREADLLAAQSLAREKEAALSQERQRISRERDELQGRLADKESQEQGLQQRLLDEQFAMLRATAAEAERILQDAVGKLDDPLHLRCTSSPDYLVSRAQAALDAVSALEKGHAQYLTSRADASGLVAALTRFSHLTADTIVHGSATSHLAPTDPADRLIDTCRECGARALELMGQLQEQQALLQARPGLVRTPLQGILQLGQELKPKSLDVREEELGAMVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTASTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKADKHSPHLSRLQECSRTVNEMAANVVASTKSGQEQVEDRDTMDFSGLSLIKLKKQEMETQVRALELEKTLEVERVRLGELRRQHYLLAGAVGTPGEEEPSQPSATPHSGTKKPPLAQKPTVAPRQDHQLDKKDGSYAAQVVN", "length": 1173, "header": "tr|A0AAA9TRR7-1|A0AAA9TRR7_BOVIN Computationally mapped isoform of Huntingtin-interacting protein 1-related protein OS=Bos taurus OX=9913 GN=HIP1R PE=1 SV=1 CANONICAL=A0AAA9SBB5-1" }, "locus": { "chromosome": "17", "start_pos": 52697276, "end_pos": 52671420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119519.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119519.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101067.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101067.1" } ] } }, { "isoform_ac": "F1MUI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5/entry#F1MUI0-1", "sequence": { "sequence": "MNSIKNVPARVLNRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSAILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNIYTKLLLTKIAFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPAVVADLFEQTFGPPNGSMKDDRDLQIEALKREVEMLRSELDKIKLEAQRFISQLKGQVNALEAELEEQRKQKQKALVDNEQLRHELAQLRAAQVEGERNQGLREEAEKKASATEARYNKLKEKHSELVNTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLVFQVEQVKRESEMKLEEQSDQLEKLKRELEAKAGELVRVQEALSRTEQSGSELSSRLDALSADRDELSRVVQQREADLLAAQSLAREKEAALSQERQRISRERDELQGRLADKESQEQGLQQRLLDEQFAMLRATAAEAERILQDAVGKLDDPLHLRCTSSPDYLVSRAQAALDAVSALEKGHAQYLTSRADASGLVAALTRFSHLTADTIVHGSATSHLAPTDPADRLIDTCRECGARALELMGQLQEQQALLQARPGLVRTPLQGILQLGQELKPKSLDVREEELGAMVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTASTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKADKHSPHLSRLQECSRTVNEMAANVVASTKSGQEQVEDRDTMDFSGLSLIKLKKQEMETQLDKKDGSYAAQVVN", "length": 998, "header": "tr|F1MUI0-1|F1MUI0_BOVIN Computationally mapped isoform of Huntingtin-interacting protein 1-related protein OS=Bos taurus OX=9913 GN=HIP1R PE=1 SV=3 CANONICAL=A0AAA9SBB5-1" }, "locus": { "chromosome": "17", "start_pos": 52697276, "end_pos": 52671420, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028783.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028783.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028783.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028783.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 989, "start_aa": "Thr", "end_pos": 989, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr989", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate binding", "id": "GO:0005547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005547", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4-bisphosphate binding", "id": "GO:0043325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "clathrin adaptor activity", "id": "GO:0035615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "clathrin light chain binding", "id": "GO:0032051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "regulation of endocytosis", "id": "GO:0030100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030100", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "membrane organization", "id": "GO:0061024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "negative regulation of actin filament polymerization", "id": "GO:0030837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "positive regulation of cellular component organization", "id": "GO:0051130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051130", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "positive regulation of transport", "id": "GO:0051050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "regulation of gastric acid secretion", "id": "GO:0060453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060453", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "positive regulation of clathrin coat assembly", "id": "GO:1905445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905445", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "positive regulation of platelet-derived growth factor receptor-beta signaling pathway", "id": "GO:2000588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000588", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "clathrin coat assembly", "id": "GO:0048268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway", "id": "GO:0097193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "digestive system development", "id": "GO:0055123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "id": "GO:1901030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "negative regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:0034316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034316", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" }, { "name": "endocytic patch", "id": "GO:0061645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061645", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" }, { "id": "PS50942", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50942" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ENTH", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 123, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB5" }, { "id": "PS50945", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50945" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "I/LWEQ", "eco_id": "ECO_0000259", "start_pos": 743, "end_pos": 984, "start_aa": "Ser", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 989 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBG6-1", "uniprot_ac": "A0AAA9SBG6", "uniprot_id": "A0AAA9SBG6_BOVIN", "mass": { "chemical_mass": 85066.0, "monoisotopic_mass": 85066.0 }, "refseq": { "ac": "XP_002695456", "name": "serine/threonine-protein kinase BRSK1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695456" }, "gene_names": [ { "name": "BRSK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ] }, { "name": "BRSK1", "type": "synonym", "evidence": [ { "id": "XP_002695456", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695456" } ] } ], "protein_names": [ { "name": "BR serine/threonine kinase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein kinase BRSK1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002695456", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695456" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRSK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6", "locus": { "chromosome": "18", "start_pos": 62166528, "end_pos": 62190532, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015226", "url": "https://www.ensembl.org/id/ENSBTAG00000015226" } ] } } ], "crossref": [ { "id": "A0AAA9SBG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015226", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015226", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14081", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14081", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538009", "url": "https://www.ncbi.nlm.nih.gov/gene/538009", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538009", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538009", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MXK4", "url": "https://www.orthodb.org/?gene=F1MXK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21115", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21115", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21122", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21122", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695456", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695456", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12801", "url": "https://www.rhea-db.org/rhea/12801", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53904", "url": "https://www.rhea-db.org/rhea/53904", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXK4", "url": "https://www.uniprot.org/uniprotkb/F1MXK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXK4-1", "url": "https://www.uniprot.org/uniprotkb/F1MXK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSGGKDGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPTGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDSSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTPPRSLQPAPGRPDPELTSSPRRGPPKDKKLLATNGSPLP", "length": 777, "header": "tr|A0AAA9SBG6-1|A0AAA9SBG6_BOVIN Isoform 1 of BR serine/threonine kinase 1 OS=Bos taurus OX=9913 GN=BRSK1 PE=3 SV=1 CANONICAL=A0AAA9SBG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6/entry#A0AAA9SBG6-1", "sequence": { "sequence": "MSSGGKDGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPTGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDSSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTPPRSLQPAPGRPDPELTSSPRRGPPKDKKLLATNGSPLP", "length": 777, "header": "tr|A0AAA9SBG6-1|A0AAA9SBG6_BOVIN Isoform 1 of BR serine/threonine kinase 1 OS=Bos taurus OX=9913 GN=BRSK1 PE=3 SV=1 CANONICAL=A0AAA9SBG6-1" }, "locus": { "chromosome": "18", "start_pos": 62190056, "end_pos": 62167532, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089851.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089851.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083431.1" } ] } }, { "isoform_ac": "F1MXK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6/entry#F1MXK4-1", "sequence": { "sequence": "LTLGKGPESPDGDVSVPERKDEVAGGGGEEEEAEERGRHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPTGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDSSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTPPRSLQPAPGRPDPELTSSPRRGPPKDKKLLATNGSPLP", "length": 789, "header": "tr|F1MXK4-1|F1MXK4_BOVIN Computationally mapped isoform of BR serine/threonine kinase 1 OS=Bos taurus OX=9913 GN=BRSK1 PE=3 SV=4 CANONICAL=A0AAA9SBG6-1" }, "locus": { "chromosome": "18", "start_pos": 62190532, "end_pos": 62167532, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020255.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020255.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020255.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020255.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 530, "start_aa": "Thr", "end_pos": 530, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr530", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538009", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538009", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "tau-protein kinase activity", "id": "GO:0050321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "regulation of axonogenesis", "id": "GO:0050770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "synaptic vesicle cycle", "id": "GO:0099504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099504", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "associative learning", "id": "GO:0008306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008306", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "G2/M transition of mitotic cell cycle", "id": "GO:0000086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "response to UV", "id": "GO:0009411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "establishment of cell polarity", "id": "GO:0030010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "centrosome duplication", "id": "GO:0051298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization involved in establishment of planar polarity", "id": "GO:0090176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 772, "end_pos": 774, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12801", "name": "", "equation": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LJI4-1", "A0A3Q1NDU7-1", "P35508-1", "A0ABI0NQQ4-1", "G5E5D4-1", "A0AAA9T8T9-1" ], "evidence": [ { "id": "12801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12801" } ] }, { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "53904", "name": "", "equation": "L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LJI4-1", "A0A3Q1NDU7-1", "P35508-1", "A0ABI0NQQ4-1", "G5E5D4-1", "A0AAA9T8T9-1" ], "evidence": [ { "id": "53904", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53904" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJI4", "gene_name": "GSK3A", "activity": [ { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJI4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0A3Q1LJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJI4" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NDU7", "gene_name": "GSK3B", "activity": [ { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 285, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBG6" }, { "id": "PS50030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA", "eco_id": "ECO_0000259", "start_pos": 314, "end_pos": 356, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 530 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 772, "end_pos": 774 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBH7-1", "uniprot_ac": "A0AAA9SBH7", "uniprot_id": "A0AAA9SBH7_BOVIN", "mass": { "chemical_mass": 29187.0, "monoisotopic_mass": 29187.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SBH7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ISSASVRNATRPDMNTSQDEEDSGSSDVSSSTENTYSDTLNSMTSLLEQFLLHKYKMKQPIMKENMLKIIHPRYHNRFAEILKRASEHEAVFAVDLKEVDSTTHSYDLVSKLNLPNNGRVWDGRGLPKTGLLMTVLGVVFVKGNCAAEEDIWKFLNMMRVYAGRKHFIYGEPRKLITKDFVTMKYLEYRQVANSDPPRYEFLWGPRAHAETSKMKVLEFLAKVNDTVPSAFSSQYEEALQDEEERFLRCKGELP", "length": 254, "header": "tr|A0AAA9SBH7-1|A0AAA9SBH7_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SBH7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7/entry#A0AAA9SBH7-1", "sequence": { "sequence": "ISSASVRNATRPDMNTSQDEEDSGSSDVSSSTENTYSDTLNSMTSLLEQFLLHKYKMKQPIMKENMLKIIHPRYHNRFAEILKRASEHEAVFAVDLKEVDSTTHSYDLVSKLNLPNNGRVWDGRGLPKTGLLMTVLGVVFVKGNCAAEEDIWKFLNMMRVYAGRKHFIYGEPRKLITKDFVTMKYLEYRQVANSDPPRYEFLWGPRAHAETSKMKVLEFLAKVNDTVPSAFSSQYEEALQDEEERFLRCKGELP", "length": 254, "header": "tr|A0AAA9SBH7-1|A0AAA9SBH7_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SBH7-1" }, "locus": { "chromosome": "NKLS02002207.1", "start_pos": 274850, "end_pos": 272910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086551.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086551.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079561.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079561.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH7" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 238, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBJ1-1", "uniprot_ac": "A0AAA9SBJ1", "uniprot_id": "A0AAA9SBJ1_BOVIN", "mass": { "chemical_mass": 30096.0, "monoisotopic_mass": 30096.0 }, "refseq": {}, "gene_names": [ { "name": "SNAI1", "type": "recommended", "evidence": [ { "id": "A0AAA9SBJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ] } ], "protein_names": [ { "name": "Snail family transcriptional repressor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SBJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNAI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1", "locus": { "chromosome": "13", "start_pos": 78042572, "end_pos": 78036445, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014554", "url": "https://www.ensembl.org/id/ENSBTAG00000014554" } ] } } ], "crossref": [ { "id": "A0AAA9SBJ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014554", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014554", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504492", "url": "https://www.ncbi.nlm.nih.gov/gene/504492", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504492", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504492", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRKAFNC", "url": "https://omabrowser.org/oma/group/TRKAFNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BMI0", "url": "https://www.orthodb.org/?gene=E1BMI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMI0", "url": "https://www.uniprot.org/uniprotkb/E1BMI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMI0-1", "url": "https://www.uniprot.org/uniprotkb/E1BMI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRSFLVRKSAGSRRRPNYSELHDSSPELTFQQPYDQAHLLAAIPPPEVLNPTASLPTLIWDSLLAPQAQPISWASLLPQEIPKAGELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSASSLEAEGYAAFPGLGQLPKQLTGLSVAKDPQSRKAFNCKYCNKEYISLGALKMHIRSHTLPCVCSTCGKAFSRPWLLQGHVRTHTGLQSPGPEFSEQGVNEEELVGLSHQTLRACYAEARQSWQSRLHGRPFPSPLAPAPRCWWPGSWWPCPRRLSP", "length": 275, "header": "tr|A0AAA9SBJ1-1|A0AAA9SBJ1_BOVIN Isoform 1 of Snail family transcriptional repressor 1 OS=Bos taurus OX=9913 GN=SNAI1 PE=3 SV=1 CANONICAL=A0AAA9SBJ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1/entry#A0AAA9SBJ1-1", "sequence": { "sequence": "MPRSFLVRKSAGSRRRPNYSELHDSSPELTFQQPYDQAHLLAAIPPPEVLNPTASLPTLIWDSLLAPQAQPISWASLLPQEIPKAGELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSASSLEAEGYAAFPGLGQLPKQLTGLSVAKDPQSRKAFNCKYCNKEYISLGALKMHIRSHTLPCVCSTCGKAFSRPWLLQGHVRTHTGLQSPGPEFSEQGVNEEELVGLSHQTLRACYAEARQSWQSRLHGRPFPSPLAPAPRCWWPGSWWPCPRRLSP", "length": 275, "header": "tr|A0AAA9SBJ1-1|A0AAA9SBJ1_BOVIN Isoform 1 of Snail family transcriptional repressor 1 OS=Bos taurus OX=9913 GN=SNAI1 PE=3 SV=1 CANONICAL=A0AAA9SBJ1-1" }, "locus": { "chromosome": "13", "start_pos": 78040167, "end_pos": 78036533, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134122.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134122.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079579.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079579.1" } ] } }, { "isoform_ac": "E1BMI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1/entry#E1BMI0-1", "sequence": { "sequence": "MPRSFLVRKSAGSRRRPNYSELHDSSPELTFQQPYDQAHLLAAIPPPEVLNPTASLPTLIWDSLLAPQAQPISWASLLPQEIPKAGELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSASSLEAEGYAAFPGLGQLPKQLTGLSVAKDPQSRKAFNCKYCNKEYISLGALKMHIRSHTLPCVCSTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCKTCSRTFSRMSLLHKHQESGCSGGPR", "length": 264, "header": "tr|E1BMI0-1|A0AAA9SBJ1_BOVIN Computationally mapped isoform of Snail family transcriptional repressor 1 OS=Bos taurus OX=9913 GN=SNAI1 PE=3 SV=1 CANONICAL=A0AAA9SBJ1-1" }, "locus": { "chromosome": "13", "start_pos": 78041745, "end_pos": 78036533, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019345.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019345.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019345.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019345.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504492", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504492", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1ULE4-1", "protein_name": "Snail family transcriptional repressor 1", "gene_name": "SNAI1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPRSFLVRKPACSRRRPNYSELHDSSPEFTFQQPYDQAHLLAAIPPPEVLNPTASLPTLIWDSLLAPQAQPIGWASLLPQEIPRAVELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSASSLEAESYAAFPGLGQLPKQLAGLSVAKDPQSRKAFNCKYCNKEYVSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCSRAFADRSNLRAHLQTHSDVKKYQCKTCSRTFSRMSLLHKHQESGCSGGPR", "length": 264 }, "evidence": [ { "id": "A0AAA9SBJ1", "url": "https://omabrowser.org/oma/group/A0AAA9SBJ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HET7-1", "protein_name": "Zinc finger protein SNAI1 isoform X1", "gene_name": "Snai1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPRSFLVRKASDPRRKPNYSELQDACVEFIFQQPYDQAHLLAAIPPPEVLNPAASLPTLIWDSLLVPQVQPVAWATLPPRESPRAAELTSLSDEDSGKSSQPPSPPSPAPSSFSSTSASSLDSEAFVSFPGLGQLPKQLARLSVAKDPQSRKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCATCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGGPR", "length": 264 }, "evidence": [ { "id": "A0AAA9SBJ1", "url": "https://omabrowser.org/oma/group/A0AAA9SBJ1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95863-1", "protein_name": "Zinc finger protein SNAI1", "gene_name": "SNAI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGCPR", "length": 264 }, "evidence": [ { "id": "A0AAA9SBJ1", "url": "https://omabrowser.org/oma/group/A0AAA9SBJ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q02085-1", "protein_name": "Zinc finger protein SNAI1", "gene_name": "Snai1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRSFLVRKPSDPRRKPNYSELQDACVEFTFQQPYDQAHLLAAIPPPEVLNPAASLPTLIWDSLLVPQVRPVAWATLPLRESPKAVELTSLSDEDSGKSSQPPSPPSPAPSSFSSTSASSLEAEAFIAFPGLGQLPKQLARLSVAKDPQSRKIFNCKYCNKEYLSLGALKMHIRSHTLPCVCTTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQESGCSGGPR", "length": 264 }, "evidence": [ { "id": "A0AAA9SBJ1", "url": "https://omabrowser.org/oma/group/A0AAA9SBJ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "negative regulation of vitamin D biosynthetic process", "id": "GO:0010957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010957", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:1902230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902230", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "mesoderm formation", "id": "GO:0001707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001707", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "osteoblast differentiation", "id": "GO:0001649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "positive regulation of epithelial to mesenchymal transition", "id": "GO:0010718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010718", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "negative regulation of DNA damage response, signal transduction by p53 class mediator", "id": "GO:0043518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043518", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "epithelial to mesenchymal transition involved in endocardial cushion formation", "id": "GO:0003198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "regulation of bicellular tight junction assembly", "id": "GO:2000810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000810", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "heterochromatin organization", "id": "GO:0070828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070828", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBJ1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 154, "end_pos": 177, "start_aa": "Phe", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCQ9-1", "uniprot_ac": "A0AAA9SCQ9", "uniprot_id": "A0AAA9SCQ9_BOVIN", "mass": { "chemical_mass": 59515.0, "monoisotopic_mass": 59515.0 }, "refseq": {}, "gene_names": [ { "name": "UAP1L1", "type": "recommended", "evidence": [ { "id": "A0AAA9SCQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9" } ] } ], "protein_names": [ { "name": "UDP-N-acetylglucosamine pyrophosphorylase 1 like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SCQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UAP1L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9", "locus": { "chromosome": "11", "start_pos": 106115897, "end_pos": 106108011, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048054", "url": "https://www.ensembl.org/id/ENSBTAG00000048054" } ] } } ], "crossref": [ { "id": "A0AAA9SCQ9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCQ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048054", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048054", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04193", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04193", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3N337", "url": "https://www.orthodb.org/?gene=G3N337", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11952:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11952:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N337", "url": "https://www.uniprot.org/uniprotkb/G3N337", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N337-1", "url": "https://www.uniprot.org/uniprotkb/G3N337-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEADLRARLQRASQEHLLRFCAELAPEPRAALLAQLEALEPEALRQHCQRAAAACARRPGPPPDLAARLQPLPLERVGSASEGDPQTRRLWEEEGFHQIALNKVAVLLLAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVEQLAGERYGTRCTVPWYIMTSEFTLEPTAKFFKEHDFFHLDPNNVIMFEQRMLPAVSFDGRAILERKDKVAMAPDGNGGLYSALEDHQILEDMERRGVEFVHVYCVDNILVRLADPLFIGFCVLRGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPEVAQLRAPGGGLLYNAGNICNHFFTRDFLRTVTRELEPLLQPHVAVKKVPCVDEHGNPVKPLQPNGIKMEKFVFDVLPFAKNFMAFQVLREEEFSPLKNADSADRDNPSTSRRALLAQHCRWALRAGARFLDVHGAQLPEQLRGWRSTCEAASSGPHSSWTRPWPGSCGPDPCQPWGPRLRTQPHLGSRQGSCSAILAADRRPQNGAGFLHKGGRPPATRALGAG", "length": 537, "header": "tr|A0AAA9SCQ9-1|A0AAA9SCQ9_BOVIN Isoform 1 of UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 OS=Bos taurus OX=9913 GN=UAP1L1 PE=3 SV=1 CANONICAL=A0AAA9SCQ9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9/entry#A0AAA9SBK5-1", "sequence": { "sequence": "MASEADLRARLQRASQEHLLRFCAELAPEPRAALLAQLEALEPEALRQHCQRAAAACARRPGPPPDLAARLQPLPLERVGSASEGDPQTRRLWEEEGFHQIALNKVAVLLLAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVEQLAGERYGTRCTVPWYIMTSEFTLEPTAKFFKEHDFFHLDPNNVIMFEQRMLPAVSFDGRAILERKDKVAMAPDGNGGLYSALEDHQILEDMERRGVEFVHVYCVDNILVRLADPLFIGFCVLRGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPEVAQLRAPGGGLLYNAGNICNHFFTRDFLRTVTRELEPLLQPHVAVKKVPCVDEHGNPVKPLQPNGIKMEKFVFDVLPFAKNFMAFQVLREEEFSPLKNADSADRDNPSTSRRALLAQHCRWALRAGARFLDVHGAQLPEQLRSHVPHHLSPRQLLIEATEF", "length": 474, "header": "tr|A0AAA9SBK5-1|A0AAA9SCQ9_BOVIN Computationally mapped isoform of UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 OS=Bos taurus OX=9913 GN=UAP1L1 PE=3 SV=1 CANONICAL=A0AAA9SCQ9-1" }, "locus": { "chromosome": "11", "start_pos": 106114461, "end_pos": 106108207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132784.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132784.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080853.1" } ] } }, { "isoform_ac": "A0AAA9SCQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9/entry#A0AAA9SCQ9-1", "sequence": { "sequence": "MASEADLRARLQRASQEHLLRFCAELAPEPRAALLAQLEALEPEALRQHCQRAAAACARRPGPPPDLAARLQPLPLERVGSASEGDPQTRRLWEEEGFHQIALNKVAVLLLAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVEQLAGERYGTRCTVPWYIMTSEFTLEPTAKFFKEHDFFHLDPNNVIMFEQRMLPAVSFDGRAILERKDKVAMAPDGNGGLYSALEDHQILEDMERRGVEFVHVYCVDNILVRLADPLFIGFCVLRGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPEVAQLRAPGGGLLYNAGNICNHFFTRDFLRTVTRELEPLLQPHVAVKKVPCVDEHGNPVKPLQPNGIKMEKFVFDVLPFAKNFMAFQVLREEEFSPLKNADSADRDNPSTSRRALLAQHCRWALRAGARFLDVHGAQLPEQLRGWRSTCEAASSGPHSSWTRPWPGSCGPDPCQPWGPRLRTQPHLGSRQGSCSAILAADRRPQNGAGFLHKGGRPPATRALGAG", "length": 537, "header": "tr|A0AAA9SCQ9-1|A0AAA9SCQ9_BOVIN Isoform 1 of UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 OS=Bos taurus OX=9913 GN=UAP1L1 PE=3 SV=1 CANONICAL=A0AAA9SCQ9-1" }, "locus": { "chromosome": "11", "start_pos": 106113167, "end_pos": 106108207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110505.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110505.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081309.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081309.1" } ] } }, { "isoform_ac": "A0AAA9SCV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9/entry#A0AAA9SCV4-1", "sequence": { "sequence": "MASEADLRARLQRASQEHLLRFCAELAPEPRAALLAQLEALEPEALRQHCQRAAAACARRPGPPPDLAARLQPLPLERVGSASEGDPQTRRLWEEEGFHQIALNKVAVLLLAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVEQLAGERYGTRCTVPWYIMTSEFTLEPTAKFFKEHDFFHLDPNNVIMFEQRMLPAVSFDGRAILERKDKVAMAPDGNGGLYSALEDHQILEDMERRGVEFVHVYCVDNILVRLADPLFIGFCVLRGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPEVAQLRAPGGGLLYNAGNICNHFFTRDFLRTVTRELEPLLQPHVAVKKVPCVDEHGNPVKPLQPNGIKMEKFVFDVLPFAKNFMAFQVLREEEFSPLKNADSADRDNPSTSRRALLAQHCRWALRAGARFLDVHGAQLPEQLSLPGSAEPPAICEISPLVSYAGEEPRAPSSLTQTAAN", "length": 491, "header": "tr|A0AAA9SCV4-1|A0AAA9SCV4_BOVIN Computationally mapped isoform of UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 OS=Bos taurus OX=9913 GN=UAP1L1 PE=3 SV=2 CANONICAL=A0AAA9SCQ9-1" }, "locus": { "chromosome": "11", "start_pos": 106114445, "end_pos": 106108207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133018.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133018.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081354.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081354.2" } ] } }, { "isoform_ac": "A0AAA9TI64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9/entry#A0AAA9TI64-1", "sequence": { "sequence": "MASEADLRARLQRASQEHLLRFCAELAPEPRAALLAQLEALEPEALRQHCQRAAAACARRPGPPPDLAARLQPLPLERVGSASEGDPQTRRLWEEEGFHQIALNKVAVLLLAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVEQLAGERYGTRCTVPWYIMTSEFTLEPTAKFFKEHDFFHLDPNNVIMFEQRMLPAVSFDGRAILERKDKVAMAPDGNGGLYSALEDHQILEDMERRGVEFVHVYCVDNILVRLADPLFIGFCVLRGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPEVAQLRAPGGGLLYNAGNICNHFFTRDFLRTVTRELEPLLQPHVAVKKVPCVDEHGNPVKPLQPNGIKMEKFVFDVLPFAKSVQKLSLFLPPPPSCGSSEAQQAGKNFMAFQVLREEEFSPLKNADSADRDNPSTSRRALLAQHCRWALRAGARFLDVHGAQLPEQLSLPGSAEPPAICEISPLVSYAGEGLEKYLRGREFRPPLILDEAMARELRP", "length": 529, "header": "tr|A0AAA9TI64-1|A0AAA9TI64_BOVIN Computationally mapped isoform of UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Bos taurus OX=9913 GN=UAP1L1 PE=3 SV=1 CANONICAL=A0AAA9SCQ9-1" }, "locus": { "chromosome": "11", "start_pos": 106113001, "end_pos": 106108207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119879.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119879.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097977.1" } ] } }, { "isoform_ac": "G3N337-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9/entry#G3N337-1", "sequence": { "sequence": "MASEADLRARLQRASQEHLLRFCAELAPEPRAALLAQLEALEPEALRQHCQRAAAACARRPGPPPDLAARLQPLPLERVGSASEGDPQTRRLWEEEGFHQIALNKVAVLLLAGGQGTRLGVTYPKGMYQVGLPSQKTLYQLQAERIRRVEQLAGERYGTRCTVPWYIMTSEFTLEPTAKFFKEHDFFHLDPNNVIMFEQRMLPAVSFDGRAILERKDKVAMAPDGNGGLYSALEDHQILEDMERRGVEFVHVYCVDNILVRLADPLFIGFCVLRGADCGAKVVEKAYPEEPVGVVCQVDGVPQVVEYSEISPEVAQLRAPGGGLLYNAGNICNHFFTRDFLRTVTRELEPLLQPHVAVKKVPCVDEHGNPVKPLQPNGIKMEKFVFDVLPFAKNFMAFQVLREEEFSPLKNADSADRDNPSTSRRALLAQHCRWALRAGARFLDVHGAQLPEQLSPGAVSGDTDLFVAIESATTLLMGNISS", "length": 482, "header": "tr|G3N337-1|G3N337_BOVIN Computationally mapped isoform of UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 OS=Bos taurus OX=9913 GN=UAP1L1 PE=3 SV=3 CANONICAL=A0AAA9SCQ9-1" }, "locus": { "chromosome": "11", "start_pos": 106115875, "end_pos": 106108207, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065653.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065653.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056310.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056310.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "uridylyltransferase activity", "id": "GO:0070569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070569", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine diphosphorylase activity", "id": "GO:0003977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "UDP-N-acetylglucosamine biosynthetic process", "id": "GO:0006048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006048", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBL0-1", "uniprot_ac": "A0AAA9SBL0", "uniprot_id": "A0AAA9SBL0_BOVIN", "mass": { "chemical_mass": 134691.0, "monoisotopic_mass": 134691.0 }, "refseq": {}, "gene_names": [ { "name": "ABI3BP", "type": "recommended", "evidence": [ { "id": "A0AAA9SBL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0" } ] } ], "protein_names": [ { "name": "ABI family member 3 binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SBL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABI3BP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0", "locus": { "chromosome": "1", "start_pos": 45188783, "end_pos": 45477184, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026836", "url": "https://www.ensembl.org/id/ENSBTAG00000026836" } ] } } ], "crossref": [ { "id": "A0AAA9SBL0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBL0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23197:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23197:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21731", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21731", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSSLGCLLLCGSIALALGNAQKLPKGKRPNLKVHINTTSDSIFLKFLRPSPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIVDAEPKYLIVVRPAPPPSQKKSCSGKKRARKPLQLVVGTLSPSSVFLSWGFLINPHHDWTLPSQCPNDRYYTIRYREKDKEKKWIFQLCPATETIVENLKPDTVYEFGVKDNVEGGIWSKIFNHKTIVGSKSKVNGKIQSTYDQVHSVPAYVPRKLIPVTIIKQVIQNVTHRASTKSPDKTPYGGTILVHLVIPGLNETTVKLPTSIMFEISEAIKTQLAKNETLALPAESKTPEVEKIPALPITVTPESVPRTTKPTVSSALDISETTLASSEKPGIVPTSKISEDSKILLPQTATYDVFSSPTTSDEPEISEPHTATSDLLLDSVPPKTSRTLEQPRATLAPSETPFISQKLEIFTSPEMQPTTPAPLQTTSVPSTPKRRLRPKTPRTKAERTTSPGTVTSKISKSPEPRRTTMAPSKTQFISLKPKVPLSPEVTDSKPAPEPEIFPPSQPPIEPGMLETKSSTTLAPPKTKRPGRRPRPKTTPSPDVPKSKPALEPATVPLEPLVPTIVFEPVTSETEAPATSIVPATDIEPVTLRTEAPRTTLAPKTSQRTRTRRPRPRPKHKTTPRPETPQTKLDFEPITPGTSLAPTTTTTTKRPRGPRPKPKTTPHPEAPQTKLASKQIPRTPPKPKTSPHPRIPQTQSAPKVFQRVTLKPKTSPSPEVSYTPPVPRDVLLPHKPDPEVSQSEPAPLETRGSPLIPMISPSTSQEELQTTLAPHRLYTTTMRPRTPDKPHIRPGVKQVPLPSGTGRNVSMDSSHPTKKPGTRRPPLPPRPMPPRRKPLPPNNVTGKPGSAGIISSDRVTSPPLRATLIPTEAPLERMETDKKQPTAPASGEDLDNITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWDKPLNDTVTEYEVISRENGSFSGKNKSIQTTNQTFSTVENLKPDTSYEFQVKPINPLGEGPPSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW", "length": 1224, "header": "tr|A0AAA9SBL0-1|A0AAA9SBL0_BOVIN Isoform 1 of ABI family member 3 binding protein OS=Bos taurus OX=9913 GN=ABI3BP PE=4 SV=1 CANONICAL=A0AAA9SBL0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0/entry#A0AAA9SBL0-1", "sequence": { "sequence": "MLSSLGCLLLCGSIALALGNAQKLPKGKRPNLKVHINTTSDSIFLKFLRPSPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIVDAEPKYLIVVRPAPPPSQKKSCSGKKRARKPLQLVVGTLSPSSVFLSWGFLINPHHDWTLPSQCPNDRYYTIRYREKDKEKKWIFQLCPATETIVENLKPDTVYEFGVKDNVEGGIWSKIFNHKTIVGSKSKVNGKIQSTYDQVHSVPAYVPRKLIPVTIIKQVIQNVTHRASTKSPDKTPYGGTILVHLVIPGLNETTVKLPTSIMFEISEAIKTQLAKNETLALPAESKTPEVEKIPALPITVTPESVPRTTKPTVSSALDISETTLASSEKPGIVPTSKISEDSKILLPQTATYDVFSSPTTSDEPEISEPHTATSDLLLDSVPPKTSRTLEQPRATLAPSETPFISQKLEIFTSPEMQPTTPAPLQTTSVPSTPKRRLRPKTPRTKAERTTSPGTVTSKISKSPEPRRTTMAPSKTQFISLKPKVPLSPEVTDSKPAPEPEIFPPSQPPIEPGMLETKSSTTLAPPKTKRPGRRPRPKTTPSPDVPKSKPALEPATVPLEPLVPTIVFEPVTSETEAPATSIVPATDIEPVTLRTEAPRTTLAPKTSQRTRTRRPRPRPKHKTTPRPETPQTKLDFEPITPGTSLAPTTTTTTKRPRGPRPKPKTTPHPEAPQTKLASKQIPRTPPKPKTSPHPRIPQTQSAPKVFQRVTLKPKTSPSPEVSYTPPVPRDVLLPHKPDPEVSQSEPAPLETRGSPLIPMISPSTSQEELQTTLAPHRLYTTTMRPRTPDKPHIRPGVKQVPLPSGTGRNVSMDSSHPTKKPGTRRPPLPPRPMPPRRKPLPPNNVTGKPGSAGIISSDRVTSPPLRATLIPTEAPLERMETDKKQPTAPASGEDLDNITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWDKPLNDTVTEYEVISRENGSFSGKNKSIQTTNQTFSTVENLKPDTSYEFQVKPINPLGEGPPSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW", "length": 1224, "header": "tr|A0AAA9SBL0-1|A0AAA9SBL0_BOVIN Isoform 1 of ABI family member 3 binding protein OS=Bos taurus OX=9913 GN=ABI3BP PE=4 SV=1 CANONICAL=A0AAA9SBL0-1" }, "locus": { "chromosome": "1", "start_pos": 45477086, "end_pos": 45189787, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111814.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111814.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082778.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082778.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of connective tissue replacement involved in inflammatory response wound healing", "id": "GO:1904597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0" } ], "pmid": "" }, { "name": "positive regulation of cardiocyte differentiation", "id": "GO:1905209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1014, "end_pos": 1016, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1027, "end_pos": 1029, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1034, "end_pos": 1036, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1041, "end_pos": 1043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 839, "end_pos": 841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 874, "end_pos": 876, "annotation": "n_glycosylation_sequon" }, { "start_pos": 927, "end_pos": 929, "annotation": "n_glycosylation_sequon" }, { "start_pos": 981, "end_pos": 983, "annotation": "n_glycosylation_sequon" }, { "start_pos": 992, "end_pos": 994, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL0" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 214, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1014, "end_pos": 1016 }, { "start_pos": 1027, "end_pos": 1029 }, { "start_pos": 1034, "end_pos": 1036 }, { "start_pos": 1041, "end_pos": 1043 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 66, "end_pos": 68 }, { "start_pos": 839, "end_pos": 841 }, { "start_pos": 874, "end_pos": 876 }, { "start_pos": 927, "end_pos": 929 }, { "start_pos": 981, "end_pos": 983 }, { "start_pos": 992, "end_pos": 994 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBL2-1", "uniprot_ac": "A0AAA9SBL2", "uniprot_id": "A0AAA9SBL2_BOVIN", "mass": { "chemical_mass": 35455.0, "monoisotopic_mass": 35455.0 }, "refseq": { "ac": "NP_001377036", "name": "olfactory receptor family 8 subfamily K member 61", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377036" }, "gene_names": [ { "name": "OR8K61", "type": "recommended", "evidence": [ { "id": "A0AAA9SBL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2" } ] }, { "name": "OR8K61", "type": "synonym", "evidence": [ { "id": "NP_001377036", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377036" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SBL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 8K3", "type": "synonym", "evidence": [ { "id": "NP_001377036", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377036" } ] }, { "name": "olfactory receptor family 8 subfamily K member 61", "type": "synonym", "evidence": [ { "id": "NP_001377036", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377036" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377036" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8K61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2", "locus": { "chromosome": "15", "start_pos": 79171790, "end_pos": 79170849, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066736", "url": "https://www.ensembl.org/id/ENSBTAG00000066736" } ] } } ], "crossref": [ { "id": "A0AAA9SBL2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15413", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15413", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528577", "url": "https://www.ncbi.nlm.nih.gov/gene/528577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377036", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTQNLTVPNEFILMGITDRPELQAPLFGLFLIIYVTSAVGNLGMVILTKVDSRLQTPMYFLLRHLALTDLGYSTAVGPKMLANFILSQNSISYYMCATQLAFFIMFIISEFFILAVMSYDRYVAICQPLLYTVIMSQRVCWILVAIPYIYSTFVSLIITVKIFNLSFCGYNVIKHFYCDCLPLISLVCSNTQEIELIILIFAGVNVILSLPIILMSYLLILVAILRMNSAEGRHKAFSTCGSHLTVVTVFFGALIFMYAQPESRHSFDTDKTASIFYTLVIPMLNPLIYSLRNKDVKYALQNVWNKLCNISS", "length": 313, "header": "tr|A0AAA9SBL2-1|A0AAA9SBL2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8K61 PE=3 SV=1 CANONICAL=A0AAA9SBL2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2/entry#A0AAA9SBL2-1", "sequence": { "sequence": "MKTQNLTVPNEFILMGITDRPELQAPLFGLFLIIYVTSAVGNLGMVILTKVDSRLQTPMYFLLRHLALTDLGYSTAVGPKMLANFILSQNSISYYMCATQLAFFIMFIISEFFILAVMSYDRYVAICQPLLYTVIMSQRVCWILVAIPYIYSTFVSLIITVKIFNLSFCGYNVIKHFYCDCLPLISLVCSNTQEIELIILIFAGVNVILSLPIILMSYLLILVAILRMNSAEGRHKAFSTCGSHLTVVTVFFGALIFMYAQPESRHSFDTDKTASIFYTLVIPMLNPLIYSLRNKDVKYALQNVWNKLCNISS", "length": 313, "header": "tr|A0AAA9SBL2-1|A0AAA9SBL2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8K61 PE=3 SV=1 CANONICAL=A0AAA9SBL2-1" }, "locus": { "chromosome": "15", "start_pos": 79171787, "end_pos": 79170849, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109651.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109651.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079605.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528577", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 }, { "start_pos": 310, "end_pos": 312 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBL3-1", "uniprot_ac": "A0AAA9SBL3", "uniprot_id": "A0AAA9SBL3_BOVIN", "mass": { "chemical_mass": 39166.0, "monoisotopic_mass": 39166.0 }, "refseq": { "ac": "XP_005211330", "name": "TBC1 domain family member 21 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211330" }, "gene_names": [ { "name": "TBC1D21", "type": "recommended", "evidence": [ { "id": "A0AAA9SBL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ] }, { "name": "TBC1D21", "type": "synonym", "evidence": [ { "id": "XP_005211330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211330" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 21", "type": "recommended", "evidence": [ { "id": "A0AAA9SBL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3/entry#names_and_taxonomy" } ] }, { "name": "Male germ cell Rab GTPase-activating protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SBL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3/entry#names_and_taxonomy" } ] }, { "name": "TBC1 domain family member 21 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005211330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211330" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3", "locus": { "chromosome": "10", "start_pos": 20704207, "end_pos": 20690589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007800", "url": "https://www.ensembl.org/id/ENSBTAG00000007800" } ] } } ], "crossref": [ { "id": "A0AAA9SBL3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBL3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007800", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007800", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506254", "url": "https://www.ncbi.nlm.nih.gov/gene/506254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NIACDIQ", "url": "https://omabrowser.org/oma/group/NIACDIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957:SF489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957:SF489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211330", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211330", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK40", "url": "https://www.uniprot.org/uniprotkb/F1MK40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK40-1", "url": "https://www.uniprot.org/uniprotkb/F1MK40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTLSPENSLSARQSASFILVKRKPPIDKTEWDGFFDENGHLAKSRDFICVNILERGLHPTVRTEAWKFLTGYYSWQSSQDERLTVDSTRRKNYEALCQMYQKIQPLLENLHRNFIETRNSITYDIKKLYDKDPLGNVLLDKKRLEKILLLSYVCNTQAEYQQGFHEMVMIFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNTLINFLDPVFAEHLKGKGAGAVPSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVRQQVLQESMTGDDILLACNNLIDLDADELISAACIVYAELIQKDVPQSLKDFFL", "length": 336, "header": "tr|A0AAA9SBL3-1|A0AAA9SBL3_BOVIN Isoform 1 of TBC1 domain family member 21 OS=Bos taurus OX=9913 GN=TBC1D21 PE=4 SV=1 CANONICAL=A0AAA9SBL3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3/entry#A0AAA9SBL3-1", "sequence": { "sequence": "MTTLSPENSLSARQSASFILVKRKPPIDKTEWDGFFDENGHLAKSRDFICVNILERGLHPTVRTEAWKFLTGYYSWQSSQDERLTVDSTRRKNYEALCQMYQKIQPLLENLHRNFIETRNSITYDIKKLYDKDPLGNVLLDKKRLEKILLLSYVCNTQAEYQQGFHEMVMIFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNTLINFLDPVFAEHLKGKGAGAVPSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVRQQVLQESMTGDDILLACNNLIDLDADELISAACIVYAELIQKDVPQSLKDFFL", "length": 336, "header": "tr|A0AAA9SBL3-1|A0AAA9SBL3_BOVIN Isoform 1 of TBC1 domain family member 21 OS=Bos taurus OX=9913 GN=TBC1D21 PE=4 SV=1 CANONICAL=A0AAA9SBL3-1" }, "locus": { "chromosome": "10", "start_pos": 20704088, "end_pos": 20690715, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111462.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111462.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080865.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080865.1" } ] } }, { "isoform_ac": "A0AAA9SDJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3/entry#A0AAA9SDJ1-1", "sequence": { "sequence": "MTTLSPENSLSARQSASFILGLHPTVRTEAWKFLTGYYSWQSSQDERLTVDSTRRKNYEALCQMYQKIQPLLENLHRNFIETRNSITYDIKKLYDKDPLGNVLLDKKRLEKILLLSYVCNTQAEYQQGFHEMVMIFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNTLINFLDPVFAEHLKGKGAGAVPSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVRQQVLQESMTGDDILLACNNLIDLDADELISAACIVYAELIQKDVPQSLKDFFL", "length": 300, "header": "tr|A0AAA9SDJ1-1|A0AAA9SDJ1_BOVIN Computationally mapped isoform of TBC1 domain family member 21 OS=Bos taurus OX=9913 GN=TBC1D21 PE=4 SV=1 CANONICAL=A0AAA9SBL3-1" }, "locus": { "chromosome": "10", "start_pos": 20704088, "end_pos": 20690715, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093584.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093584.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080405.1" } ] } }, { "isoform_ac": "F1MK40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3/entry#F1MK40-1", "sequence": { "sequence": "MTTLSPENSLSARQSASFILVKRKPPIDKTEWDGFFDENGHLAKSRDFICVNILERGLHPTVRTEAWKFLTGYYSWQSSQDERLTVDSTRRKNYEALCQMYQKIQPLLENLHRNFIETRNSIKYQQGFHEMVMIFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNTLINFLDPVFAEHLKGKGAGAVPSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVRQQVLQESMTGDDILLACNNLIDLDADELISAACIVYAELIQKDVPQSLKDFFL", "length": 299, "header": "tr|F1MK40-1|A0AAA9SBL3_BOVIN Computationally mapped isoform of TBC1 domain family member 21 OS=Bos taurus OX=9913 GN=TBC1D21 PE=4 SV=1 CANONICAL=A0AAA9SBL3-1" }, "locus": { "chromosome": "10", "start_pos": 20704088, "end_pos": 20690715, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047313.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047313.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044529.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044529.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TLT3-1", "protein_name": "TBC1 domain family member 21", "gene_name": "TBC1D21", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTTLSPENSLSARQSASFILVKRKPPIDKTEWDGFFDENGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYYSWQSSQDERLTVDSTRRKNYEALCQMYEKIQPLLENLHRNFTETRNNITYDIQKLYDKDPLGNVLIDKKRLEKILLLSYVCNTEAEYQQGFHDMVMLFHLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNILINFLDPVFSDHLKGKGAGAVQSLFPWFCLCFQHAFKSFDDVWRLWEVLLTGKPCRNSQVLVAYSMLQMVREQVLQESMTGDDILLACNNLIDLDADELISAACIVYAELIQKDVPQPLKDFLL", "length": 336 }, "evidence": [ { "id": "A0AAA9SBL3", "url": "https://omabrowser.org/oma/group/A0AAA9SBL3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MZW4-1", "protein_name": "TBC1 domain family member 21", "gene_name": "Tbc1d21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTLSPENSLSARRSATFILEKRNPPIDKTEWDSFFDENGHLAKTRDFICVNILERGLHPFVRTEAWKFLTGYYSWQSSRDERLMVDANRRRNYKVLCQMYEKIRPLLENLHGNFTETRNNIAYDIQKLYDKDPLGNVLVDKKKLEKTLLLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNSLIALLDPEFAEHLKGKGSGAVQSLFPWFCLCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLESMSGDAILLACNNLIDLDADELISAACLVYAELMQKEIPGPLKDFFL", "length": 336 }, "evidence": [ { "id": "A0AAA9SBL3", "url": "https://omabrowser.org/oma/group/A0AAA9SBL3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E9PT72-1", "protein_name": "TBC1 domain family member 21", "gene_name": "Tbc1d21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTLSPENSLSARRSATFILEKKNPPIDKAEWDSFFDENGHLAKSRDFICVNILERGLHPLVRADAWKFLTGYYSWQSSRDERLMVDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETRNNIVYDIQKLYDKDPLGNVLVDKKKLEKTLLLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNNLITLLDPQFADHLKGKGSGAVQSLFPWFCLCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLECMSGDAILMACNKLIDLDADELISAACVVYSELIQKEVPQALKDFFL", "length": 336 }, "evidence": [ { "id": "A0AAA9SBL3", "url": "https://omabrowser.org/oma/group/A0AAA9SBL3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IYX1-1", "protein_name": "TBC1 domain family member 21", "gene_name": "TBC1D21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRNNIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL", "length": 336 }, "evidence": [ { "id": "A0AAA9SBL3", "url": "https://omabrowser.org/oma/group/A0AAA9SBL3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D9D3-1", "protein_name": "TBC1 domain family member 21", "gene_name": "Tbc1d21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTLSPENSLSARRSATFILEKRNPPIDKAEWDSFFDENGHLAKSRDFICINILERGLHPFVRTEAWKFLTGYYSWQSSRDERLMVDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETRNNIAYDIQRLYDKDPLGNVLIDKKKLEKTLLLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNSLITLLDPEFAEHLKGKGSGAVQSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLECMSGDAILMACNNLIDLDADELISAACVVYSELMQKEVPQPLKEFLL", "length": 336 }, "evidence": [ { "id": "A0AAA9SBL3", "url": "https://omabrowser.org/oma/group/A0AAA9SBL3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" }, { "name": "plasma membrane to endosome transport", "id": "GO:0048227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL3" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 265, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBT0-1", "uniprot_ac": "A0AAA9SBT0", "uniprot_id": "A0AAA9SBT0_BOVIN", "mass": { "chemical_mass": 28078.0, "monoisotopic_mass": 28078.0 }, "refseq": {}, "gene_names": [ { "name": "NPW", "type": "recommended", "evidence": [ { "id": "A0AAA9SBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0" } ] } ], "protein_names": [ { "name": "Neuropeptide W", "type": "recommended", "evidence": [ { "id": "A0AAA9SBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPW", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SBT0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28553", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28553", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28553:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28553:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15180", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15180", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AHVLRRGLGSSSPFIPPPPFREPGRYRGGEQGRGRRAVIARPAGPNSPPAAPALRLLHAARADPTEPVPGPRLRADVDVSTLARGTRVRGPGRGATASRRLLALLWLLLLPPSAGAWYKHVASPRYHTVGRAAGLLMGLRRSPYMWRRAAGPLTWDTLGLGALPQGPSARSTLSPGPAALDALLLPSGAQRPWEARRRSSGAGLRVSAPRNLPAPESARQPEWRPGAYSWILAEQARAFGESPAQPRSAQGTAFASPRLAPKQS", "length": 264, "header": "tr|A0AAA9SBT0-1|A0AAA9SBT0_BOVIN Isoform 1 of Neuropeptide W OS=Bos taurus OX=9913 GN=NPW PE=3 SV=1 CANONICAL=A0AAA9SBT0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0/entry#A0AAA9SBT0-1", "sequence": { "sequence": "AHVLRRGLGSSSPFIPPPPFREPGRYRGGEQGRGRRAVIARPAGPNSPPAAPALRLLHAARADPTEPVPGPRLRADVDVSTLARGTRVRGPGRGATASRRLLALLWLLLLPPSAGAWYKHVASPRYHTVGRAAGLLMGLRRSPYMWRRAAGPLTWDTLGLGALPQGPSARSTLSPGPAALDALLLPSGAQRPWEARRRSSGAGLRVSAPRNLPAPESARQPEWRPGAYSWILAEQARAFGESPAQPRSAQGTAFASPRLAPKQS", "length": 264, "header": "tr|A0AAA9SBT0-1|A0AAA9SBT0_BOVIN Isoform 1 of Neuropeptide W OS=Bos taurus OX=9913 GN=NPW PE=3 SV=1 CANONICAL=A0AAA9SBT0-1" }, "locus": { "chromosome": "25", "start_pos": 1571104, "end_pos": 1570050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129250.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129250.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082847.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082847.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBU3-1", "uniprot_ac": "A0AAA9SBU3", "uniprot_id": "A0AAA9SBU3_BOVIN", "mass": { "chemical_mass": 46749.0, "monoisotopic_mass": 46749.0 }, "refseq": {}, "gene_names": [ { "name": "AGER", "type": "recommended", "evidence": [ { "id": "A0AAA9SBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ] } ], "protein_names": [ { "name": "Advanced glycosylation end product-specific receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#names_and_taxonomy" } ] }, { "name": "Receptor for advanced glycosylation end products", "type": "synonym", "evidence": [ { "id": "A0AAA9SBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AGER", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3", "locus": { "chromosome": "23", "start_pos": 27209270, "end_pos": 27206155, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014420", "url": "https://www.ensembl.org/id/ENSBTAG00000014420" } ] } } ], "crossref": [ { "id": "A0AAA9SBU3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014420", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014420", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N306", "url": "https://www.orthodb.org/?gene=F1N306", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZD3", "url": "https://www.orthodb.org/?gene=G3MZD3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N2L6", "url": "https://www.orthodb.org/?gene=G3N2L6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N301", "url": "https://www.orthodb.org/?gene=G3N301", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11973:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11973:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-445989", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445989", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-879415", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879415", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-933542", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-933542", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N306", "url": "https://www.uniprot.org/uniprotkb/F1N306", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N306-1", "url": "https://www.uniprot.org/uniprotkb/F1N306-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZD3", "url": "https://www.uniprot.org/uniprotkb/G3MZD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZD3-1", "url": "https://www.uniprot.org/uniprotkb/G3MZD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2L6", "url": "https://www.uniprot.org/uniprotkb/G3N2L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2L6-1", "url": "https://www.uniprot.org/uniprotkb/G3N2L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N301", "url": "https://www.uniprot.org/uniprotkb/G3N301", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N301-1", "url": "https://www.uniprot.org/uniprotkb/G3N301-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDQNITARIGKPVVLNCKGAPKKPPQQLEWKLVSGAPVSPLLGTPVRFAPPPAHLPSSSVLSQRACTVEAPLLCPQNTGRTEAWKVLSPQGDPWDSVARVLPNGSLLLPAVGIQDEGTFRCRATSRSGKETKSNYRVRVYQIPGKPEIVDPASELMAGVPNKVGTCVSEGGYPAGTLNWLLDGKTLIPDGKGVSVKEETKRHPKTGLFTLHSELMVTPARGGALHPTFSCSFTPGLPRRRALHTAPIQLRVWSERRGGEGPNVDAVPLKEVQLVVEPEGGAVAPGGTVTLTCEAPAQPPPQIHWIKDGRPLPLPPGPMLLLPEVGPEDQGTYSCVATHPSHGPQESRAVSVSIIETGEEGTTAGSVEGPGLETLALTLGILGGLGTVALLIGVIVWHRRRQRKGQERKVPENQEEEEEERAELNQPEEPEAAESSTGGP", "length": 440, "header": "tr|A0AAA9SBU3-1|A0AAA9SBU3_BOVIN Isoform 1 of Advanced glycosylation end product-specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=1 CANONICAL=A0AAA9SBU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#A0AAA9SBU3-1", "sequence": { "sequence": "MGDQNITARIGKPVVLNCKGAPKKPPQQLEWKLVSGAPVSPLLGTPVRFAPPPAHLPSSSVLSQRACTVEAPLLCPQNTGRTEAWKVLSPQGDPWDSVARVLPNGSLLLPAVGIQDEGTFRCRATSRSGKETKSNYRVRVYQIPGKPEIVDPASELMAGVPNKVGTCVSEGGYPAGTLNWLLDGKTLIPDGKGVSVKEETKRHPKTGLFTLHSELMVTPARGGALHPTFSCSFTPGLPRRRALHTAPIQLRVWSERRGGEGPNVDAVPLKEVQLVVEPEGGAVAPGGTVTLTCEAPAQPPPQIHWIKDGRPLPLPPGPMLLLPEVGPEDQGTYSCVATHPSHGPQESRAVSVSIIETGEEGTTAGSVEGPGLETLALTLGILGGLGTVALLIGVIVWHRRRQRKGQERKVPENQEEEEEERAELNQPEEPEAAESSTGGP", "length": 440, "header": "tr|A0AAA9SBU3-1|A0AAA9SBU3_BOVIN Isoform 1 of Advanced glycosylation end product-specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=1 CANONICAL=A0AAA9SBU3-1" }, "locus": { "chromosome": "23", "start_pos": 27209102, "end_pos": 27206407, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129413.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129413.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079701.1" } ] } }, { "isoform_ac": "A0AAA9TRC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#A0AAA9TRC6-1", "sequence": { "sequence": "MAAGAVVGAWMLVLSLWGTVMGDQNITARIGKPVVLNCKGAPKKPPQQLEWKLNTGRTEAWKVLSPQGDPWDSVARVLPNGSLLLPAVGIQDEGTFRCRATSRSGKETKSNYRVRVYRCENLQSCGL", "length": 127, "header": "tr|A0AAA9TRC6-1|A0AAA9TRC6_BOVIN Computationally mapped isoform of Advanced glycosylation end-product specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=1 CANONICAL=A0AAA9SBU3-1" }, "locus": { "chromosome": "23", "start_pos": 27206986, "end_pos": 27206174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115199.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115199.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099862.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099862.1" } ] } }, { "isoform_ac": "F1N306-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#F1N306-1", "sequence": { "sequence": "MAAGAVVGAWMLVLSLWGTVMGDQNITARIGKPVVLNCKGAPKKPPQQLEWKLNTGRTEAWKVLSPQGDPWDSVARVLPNGSLLLPAVGIQDEGTFRCRATSRSGKETKSNYRVRVYQIPGKPEIVDPASELMAGVPNKVGTCVSEGGYPAGTLNWLLDGKTLIPDGKGVSVKEETKRHPKTGLFTLHSELMVTPARGGALHPTFSCSFTPGLPRRRALHTAPIQLRVWNAVPLKEVQLVVEPEGGAVAPGGTVTLTCEAPAQPPPQIHWIKDGRPLPLPPGPMLLLPEVGPEDQGTYSCVATHPSHGPQESRAVSVSIIGSVEGPGLETLALTLGILGGLGTVALLIGVIVWHRRRQRKGQERKVPENQEEEEEERAELNQPEEPEAAESSTGGP", "length": 396, "header": "tr|F1N306-1|F1N306_BOVIN Computationally mapped isoform of Advanced glycosylation end product-specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=2 CANONICAL=A0AAA9SBU3-1" }, "locus": { "chromosome": "23", "start_pos": 27209102, "end_pos": 27206174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019179.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019179.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019179.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019179.3" } ] } }, { "isoform_ac": "G3MZD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#G3MZD3-1", "sequence": { "sequence": "MAAGAVVGAWMLVLSLWGTVMGDQNITARIGKPVVLNCKGAPKKPPQQLEWKLNTGRTEAWKVLSPQGDPWDSVARVLPNGSLLLPAVGIQDEGTFRCRATSRSGKETKSNYRVRVYQIPGKPEIVDPASELMAGVPNKVGTCVSEGGYPAGTLNWLLDGKTLIPDGKGVSVKEETKRHPKTGLFTLHSELMVTPARGGALHPTFSCSFTPGLPRRRALHTAPIQLRVWSERRGGEGPNVDAVPLKEVQLVVEPEGGAVAPGGTVTLTCEAPAQPPPQIHWIKDKQARRGRLQALWKGRGWKP", "length": 303, "header": "tr|G3MZD3-1|G3MZD3_BOVIN Computationally mapped isoform of Advanced glycosylation end product-specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=2 CANONICAL=A0AAA9SBU3-1" }, "locus": { "chromosome": "23", "start_pos": 27208783, "end_pos": 27206174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066156.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066156.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054930.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054930.2" } ] } }, { "isoform_ac": "G3N2L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#G3N2L6-1", "sequence": { "sequence": "MAAGAVVGAWMLVLSLWGTVMGDQNITARIGKPVVLNCKGAPKKPPQQLEWKLNTGRTEAWKVLSPQGDPWDSVARVLPNGSLLLPAVGIQDEGTFRCRATSRSGKETKSNYRVRVYQIPGKPEIVDPASELMAGVPNKVGTCVSEGGYPAGTLNWLLDGKTLIPDGKGVSVKEETKRHPKTGLFTLHSELMVTPARGGALHPTFSCSFTPGLPRRRALHTAPIQLRVWSERRGGEGPNVDAVPLKEVQLVVEPEGGAVAPGGTVTLTCEAPAQPPPQIHWIKDVSDLRGGWQALWKGRGWKP", "length": 303, "header": "tr|G3N2L6-1|G3N2L6_BOVIN Computationally mapped isoform of Advanced glycosylation end product-specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=2 CANONICAL=A0AAA9SBU3-1" }, "locus": { "chromosome": "23", "start_pos": 27208783, "end_pos": 27206174, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063820.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063820.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056131.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056131.2" } ] } }, { "isoform_ac": "G3N301-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3/entry#G3N301-1", "sequence": { "sequence": "MRGLSGAGQRAGAERRPSLTTESESIRFLGSQKLLILPLNSWLVSPIRQILYHLSNWILLFPEMMKLIFPQVGTCVSEGGYPAGTLNWLLDGKTLIPDGKGVSVKEETKRHPKTGLFTLHSELMVTPARGGALHPTFSCSFTPGLPRRRALHTAPIQLRVWSERRGGEGPNVDAVPLKEVQLVVEPEGGAVAPGGTVTLTCEAPAQPPPQIHWIKDGRPLPLPPGPMLLLPEVGPEDQGTYSCVATHPSHGPQESRAVSVSIIETGEEGTTAGSVEGPGLETLALTLGILGGLGTVALLIGVIVWHRRRQRKGQERKVPENQEEEEEERAELNQPEEPEAAESSTGGP", "length": 348, "header": "tr|G3N301-1|G3N301_BOVIN Computationally mapped isoform of Advanced glycosylation end-product specific receptor OS=Bos taurus OX=9913 GN=AGER PE=4 SV=1 CANONICAL=A0AAA9SBU3-1" }, "locus": { "chromosome": "23", "start_pos": 27209102, "end_pos": 27206753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065259.2", "url": "https://www.ensembl.org/id/ENSBTAT00000065259.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056272.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056272.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-445989", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445989", "resource": "Reactome", "description": "TAK1-dependent IKK and NF-kappa-B activation" }, { "id": "R-BTA-879415", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879415", "resource": "Reactome", "description": "Advanced glycosylation endproduct receptor signaling" }, { "id": "R-BTA-933542", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-933542", "resource": "Reactome", "description": "TRAF6 mediated NF-kB activation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 47, "go_terms": [ { "name": "positive regulation of dendritic cell differentiation", "id": "GO:2001200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "negative regulation of interleukin-10 production", "id": "GO:0032693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "regulation of T cell mediated cytotoxicity", "id": "GO:0001914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "regulation of CD4-positive, alpha-beta T cell activation", "id": "GO:2000514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "microglial cell activation", "id": "GO:0001774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "learning or memory", "id": "GO:0007611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007611", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "astrocyte activation", "id": "GO:0048143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048143", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "negative regulation of long-term synaptic potentiation", "id": "GO:1900272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900272", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "cellular response to amyloid-beta", "id": "GO:1904646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904646", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of chemokine production", "id": "GO:0032722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032722", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "negative regulation of long-term synaptic depression", "id": "GO:1900453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900453", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of p38MAPK cascade", "id": "GO:1900745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900745", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of interleukin-1 beta production", "id": "GO:0032731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "transcytosis", "id": "GO:0045056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045056", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of activated T cell proliferation", "id": "GO:0042104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair", "id": "GO:2000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of heterotypic cell-cell adhesion", "id": "GO:0034116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated DNA replication", "id": "GO:2000105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000105", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of interleukin-12 production", "id": "GO:0032735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "glucose mediated signaling pathway", "id": "GO:0010255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of monocyte extravasation", "id": "GO:2000439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000439", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "regulation of spontaneous synaptic transmission", "id": "GO:0150003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150003", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of amyloid precursor protein catabolic process", "id": "GO:1902993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "negative regulation of blood circulation", "id": "GO:1903523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903523", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of endothelin production", "id": "GO:1904472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904472", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "transport across blood-brain barrier", "id": "GO:0150104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of cell differentiation", "id": "GO:0045597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "negative regulation of biosynthetic process", "id": "GO:0009890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009890", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "positive regulation of multicellular organismal process", "id": "GO:0051240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051240", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "phagocytic cup", "id": "GO:0001891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "S100 protein binding", "id": "GO:0044548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044548", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBU3" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 139, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBV7-1", "uniprot_ac": "A0AAA9SBV7", "uniprot_id": "A0AAA9SBV7_BOVIN", "mass": { "chemical_mass": 17412.0, "monoisotopic_mass": 17412.0 }, "refseq": { "ac": "XP_059739869", "name": "ARL14 effector protein-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739869" }, "gene_names": [ { "name": "LOC112441485", "type": "recommended", "evidence": [ { "id": "A0AAA9SBV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7" } ] }, { "name": "LOC112441485", "type": "synonym", "evidence": [ { "id": "XP_059739869", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739869" } ] } ], "protein_names": [ { "name": "ARF7 effector protein C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SBV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7/entry#names_and_taxonomy" } ] }, { "name": "ARL14 effector protein-like", "type": "synonym", "evidence": [ { "id": "XP_059739869", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739869" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112441485", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7", "locus": {} } ], "crossref": [ { "id": "112441485", "url": "https://www.ncbi.nlm.nih.gov/gene/112441485", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029264", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029264", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112441485", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441485", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLDENCL", "url": "https://omabrowser.org/oma/group/CLDENCL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46536", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46536", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46536:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46536:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14949", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14949", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739869", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739869", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEQAEKSSSVRERPARQSSPEKPSEKELKQMKCLDPQLKRLSFQNPWPQVANFNPEVRQQIKKGQMAKKNELVPEKREVNKYDEKGRLTFNKADLCDCLDEGCLGCFYPCPKCKSTKCGPTCRCNRRWAYDTIVDENGEVISKMPFDLSD", "length": 151, "header": "tr|A0AAA9SBV7-1|A0AAA9SBV7_BOVIN Isoform 1 of ARF7 effector protein C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC112441485 PE=4 SV=1 CANONICAL=A0AAA9SBV7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7/entry#A0AAA9SBV7-1", "sequence": { "sequence": "MSEQAEKSSSVRERPARQSSPEKPSEKELKQMKCLDPQLKRLSFQNPWPQVANFNPEVRQQIKKGQMAKKNELVPEKREVNKYDEKGRLTFNKADLCDCLDEGCLGCFYPCPKCKSTKCGPTCRCNRRWAYDTIVDENGEVISKMPFDLSD", "length": 151, "header": "tr|A0AAA9SBV7-1|A0AAA9SBV7_BOVIN Isoform 1 of ARF7 effector protein C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC112441485 PE=4 SV=1 CANONICAL=A0AAA9SBV7-1" }, "locus": { "chromosome": "X", "start_pos": 123990486, "end_pos": 123990034, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117875.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117875.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080984.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080984.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112441485", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441485", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBV7" }, { "id": "PF14949", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14949" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ARF7 effector protein C-terminal", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 136, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBW6-1", "uniprot_ac": "A0AAA9SBW6", "uniprot_id": "A0AAA9SBW6_BOVIN", "mass": { "chemical_mass": 35064.0, "monoisotopic_mass": 35064.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "C2H2-type domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SBW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SBW6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKHLARFQIIIKKKETTGIKLYKFSIYGQVLMHHSSFNRHMTSHTTPKSCEYQEYEEKPYKCKECGKAFKHRQSRHTHEKIHSGEKPYDCKKCGKAFKLRQSIQRHERIHTGEKPYECKRCGKAFRYYHNFQKHERTHTGEKPYRCKHCDKALSSLRYCRIHEITHTGEKPYKCKQCGKAFSCPSYFIKHERIHSGLKPYEYKQCGKAFSCASYIRRHERTHTGEKPYECKKCGKAFSCSSSFRKHERTHTGEKLYECKQCGKAFSNSRSFQSHERRHSGEKPYTGKNCDKKSSM", "length": 296, "header": "tr|A0AAA9SBW6-1|A0AAA9SBW6_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SBW6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6/entry#A0AAA9SBW6-1", "sequence": { "sequence": "MGKHLARFQIIIKKKETTGIKLYKFSIYGQVLMHHSSFNRHMTSHTTPKSCEYQEYEEKPYKCKECGKAFKHRQSRHTHEKIHSGEKPYDCKKCGKAFKLRQSIQRHERIHTGEKPYECKRCGKAFRYYHNFQKHERTHTGEKPYRCKHCDKALSSLRYCRIHEITHTGEKPYKCKQCGKAFSCPSYFIKHERIHSGLKPYEYKQCGKAFSCASYIRRHERTHTGEKPYECKKCGKAFSCSSSFRKHERTHTGEKLYECKQCGKAFSNSRSFQSHERRHSGEKPYTGKNCDKKSSM", "length": 296, "header": "tr|A0AAA9SBW6-1|A0AAA9SBW6_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SBW6-1" }, "locus": { "chromosome": "7", "start_pos": 13003758, "end_pos": 13001744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079967.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079967.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082877.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082877.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 88, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBX5-1", "uniprot_ac": "A0AAA9SBX5", "uniprot_id": "A0AAA9SBX5_BOVIN", "mass": { "chemical_mass": 21264.0, "monoisotopic_mass": 21264.0 }, "refseq": {}, "gene_names": [ { "name": "PRR3", "type": "recommended", "evidence": [ { "id": "A0AAA9SBX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5" } ] } ], "protein_names": [ { "name": "Proline-rich protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SBX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5/entry#names_and_taxonomy" } ] }, { "name": "MHC class I region proline-rich protein CAT56", "type": "synonym", "evidence": [ { "id": "A0AAA9SBX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5", "locus": { "chromosome": "23", "start_pos": 28415008, "end_pos": 28421221, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006914", "url": "https://www.ensembl.org/id/ENSBTAG00000006914" } ] } } ], "crossref": [ { "id": "A0AAA9SBX5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBX5", "database": "AlphaFoldDB", "categories": [] }, { "id": "525344", "url": "https://www.ncbi.nlm.nih.gov/gene/525344", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47398:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47398:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00642", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00642", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DME9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DME9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK93", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK93-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMQAIAATTMPKRKKQNQQQQLQQQPPLPERDETGDEEDGSPIGPPSLLGPPPMANGKPGDPKSAFHRGPPGSRGPMIPPLLSLPPPPRGRGPIRGGLGPRSGPYGRGWWGVNAEPPFPGPGHGGPSRGGFHKEQRNPRRLKSWSLIKNTCPPKDGPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYHPGVNGPPL", "length": 196, "header": "tr|A0AAA9SBX5-1|A0AAA9SBX5_BOVIN Isoform 1 of Proline-rich protein 3 OS=Bos taurus OX=9913 GN=PRR3 PE=4 SV=1 CANONICAL=A0AAA9SBX5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5/entry#A0AAA9SBX5-1", "sequence": { "sequence": "MMQAIAATTMPKRKKQNQQQQLQQQPPLPERDETGDEEDGSPIGPPSLLGPPPMANGKPGDPKSAFHRGPPGSRGPMIPPLLSLPPPPRGRGPIRGGLGPRSGPYGRGWWGVNAEPPFPGPGHGGPSRGGFHKEQRNPRRLKSWSLIKNTCPPKDGPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYHPGVNGPPL", "length": 196, "header": "tr|A0AAA9SBX5-1|A0AAA9SBX5_BOVIN Isoform 1 of Proline-rich protein 3 OS=Bos taurus OX=9913 GN=PRR3 PE=4 SV=1 CANONICAL=A0AAA9SBX5-1" }, "locus": { "chromosome": "23", "start_pos": 28420991, "end_pos": 28416186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079734.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079734.1" } ] } }, { "isoform_ac": "A0AAA9SSY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5/entry#A0AAA9SSY1-1", "sequence": { "sequence": "MMQAIAATTMPKRKKQNQQQQLQQQPPLPERDETGDEEDGSPIAFHRGPPGSRGPMIPPLLSLPPPPRGRGPIRGGLGPRSGPYGRGWWGVNAEPPFPGPGHGGPSRGGFHKEQRNPRRLKSWSLIKNTCPPKDGPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYHPGVNGPPL", "length": 175, "header": "tr|A0AAA9SSY1-1|A0AAA9SSY1_BOVIN Computationally mapped isoform of Proline-rich protein 3 OS=Bos taurus OX=9913 GN=PRR3 PE=4 SV=1 CANONICAL=A0AAA9SBX5-1" }, "locus": { "chromosome": "23", "start_pos": 28420991, "end_pos": 28416186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109946.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109946.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087098.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087098.1" } ] } }, { "isoform_ac": "A0AAF6DME9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5/entry#A0AAF6DME9-1", "sequence": { "sequence": "MPKRKKQNQQQQLQQQPPLPERDETGDEEDGSPIGEEPWRGPPSLLGPPPMANGKPGDPKSAFHRGPPGSRGPMIPPLLSLPPPPRGRGPIRGGLGPRSGPYGRGWWGVNAEPPFPGPGHGGPSRGGFHKEQRNPRRLKSWSLIKNTCPPKDGPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYHPGVNGPPL", "length": 193, "header": "tr|A0AAF6DME9-1|A0AAF6DME9_BOVIN Computationally mapped isoform of Proline-rich protein 3 OS=Bos taurus OX=9913 GN=PRR3 PE=4 SV=1 CANONICAL=A0AAA9SBX5-1" }, "locus": { "chromosome": "23", "start_pos": 28420045, "end_pos": 28416186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009075.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009075.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009075.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009075.7" } ] } }, { "isoform_ac": "A0ABI0NK93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5/entry#A0ABI0NK93-1", "sequence": { "sequence": "MMQAFHRGPPGSRGPMIPPLLSLPPPPRGRGPIRGGLGPRSGPYGRGWWGVNAEPPFPGPGHGGPSRGGFHKEQRNPRRLKSWSLIKNTCPPKDGPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYHPGVNGPPL", "length": 135, "header": "tr|A0ABI0NK93-1|A0ABI0NK93_BOVIN Computationally mapped isoform of Proline-rich protein 3 OS=Bos taurus OX=9913 GN=PRR3 PE=4 SV=1 CANONICAL=A0AAA9SBX5-1" }, "locus": { "chromosome": "23", "start_pos": 28420991, "end_pos": 28416186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145654.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145654.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104767.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104767.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX5" }, { "id": "PS50103", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50103" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C3H1-type", "eco_id": "ECO_0000259", "start_pos": 163, "end_pos": 191, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBZ5-1", "uniprot_ac": "A0AAA9SBZ5", "uniprot_id": "A0AAA9SBZ5_BOVIN", "mass": { "chemical_mass": 19248.0, "monoisotopic_mass": 19248.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SBZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SBZ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19339:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19339:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SBZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "KETLLGNKHLIRLTLLLPIAFLNRNNGQQIKHFPEFLLLQEGENFTTYCNSSSILRSLQWYKQSPGGSLVLLMILVKGGEQDGRLNATTVPKEGCSSLHISSSQTTDSGTYFCAVQHSAPQVPAASTQTLHGAQPLLQPQSHHEATTQHLRCLMLLTYISTVLTTDTFWPYRL", "length": 173, "header": "tr|A0AAA9SBZ5-1|A0AAA9SBZ5_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SBZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5/entry#A0AAA9SBZ5-1", "sequence": { "sequence": "KETLLGNKHLIRLTLLLPIAFLNRNNGQQIKHFPEFLLLQEGENFTTYCNSSSILRSLQWYKQSPGGSLVLLMILVKGGEQDGRLNATTVPKEGCSSLHISSSQTTDSGTYFCAVQHSAPQVPAASTQTLHGAQPLLQPQSHHEATTQHLRCLMLLTYISTVLTTDTFWPYRL", "length": 173, "header": "tr|A0AAA9SBZ5-1|A0AAA9SBZ5_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SBZ5-1" }, "locus": { "chromosome": "10", "start_pos": 23339526, "end_pos": 23316668, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104043.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104043.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081403.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBZ5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 131, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 44, "end_pos": 46 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC18-1", "uniprot_ac": "A0AAA9SC18", "uniprot_id": "A0AAA9SC18_BOVIN", "mass": { "chemical_mass": 72903.0, "monoisotopic_mass": 72903.0 }, "refseq": { "ac": "XP_015317046", "name": "nuclear RNA export factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317046" }, "gene_names": [ { "name": "NXF2", "type": "recommended", "evidence": [ { "id": "A0AAA9SC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" } ] }, { "name": "NXF2", "type": "synonym", "evidence": [ { "id": "XP_015317046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317046" } ] } ], "protein_names": [ { "name": "Nuclear RNA export factor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18/entry#names_and_taxonomy" } ] }, { "name": "nuclear RNA export factor 2", "type": "synonym", "evidence": [ { "id": "XP_015317046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317046" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NXF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18", "locus": {} } ], "crossref": [ { "id": "A0AAA9SC18", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC18", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005319", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005319", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14342", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14342", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613789", "url": "https://www.ncbi.nlm.nih.gov/gene/613789", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613789", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613789", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10662:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10662:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03943", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03943", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015317046", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317046", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6I2", "url": "https://www.uniprot.org/uniprotkb/G3X6I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6I2-1", "url": "https://www.uniprot.org/uniprotkb/G3X6I2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSERKHQRKNTHPTKNNGTYKNEEYRGGDSSPEGRNEGWSSFQDDFDKRSPRYEDNEYETQPSHHSDDDGSMVMRNVHEGPKERHFPYSFRGNGRRVRWRREGNICVTVWGNGKPVMRKMRENTQDGAQGSWFKVTIPHGKKYDKMWLMNSIQSLCSVCFTPVDFHYVKNGARFFVQKASTASALMDVSYKIYDEENQKIPIFVNPSAVPYSVRNKLRPEKMEKLKLAFNKRFDVSQQSLDLQKLRFDPNLMGHDIEIILNQRNCMAAALQIIKKNFPELLSLNLSCNKLYHLDGLSDIVHMVPTIKILNLSNNELNSMWELNKMKGLKLEELWLRGNPLCNRFPDQSTYLSAVIECFPKLLRLDGQELPSTVVTDSHPPCATKPSKENNKEPDTLKNMILQFLKQYYLIYDSGNRYGLLSAYHHKACFSLTIPFHSEDPGLSSLCAYFKDSRNMKKVKDPNLRVQQLKHTNSDIVRALCMLPKTQHDLSSFLVDMWFQTGTMLCFSVNGMFKEVEGGSQECVRAFTRTFIITPTSSSSLCIVNDELFVMEARPKNTQSAVSIPVPTPSTSSVATLSEEQQQMVQAFSTQSGMNCQWSQKCLQDNDWNYTRAGQVFCMFKTEGKIPEEAFKEIP", "length": 634, "header": "tr|A0AAA9SC18-1|A0AAA9SC18_BOVIN Isoform 1 of Nuclear RNA export factor 2 OS=Bos taurus OX=9913 GN=NXF2 PE=3 SV=1 CANONICAL=A0AAA9SC18-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SC18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18/entry#A0AAA9SC18-1", "sequence": { "sequence": "MSERKHQRKNTHPTKNNGTYKNEEYRGGDSSPEGRNEGWSSFQDDFDKRSPRYEDNEYETQPSHHSDDDGSMVMRNVHEGPKERHFPYSFRGNGRRVRWRREGNICVTVWGNGKPVMRKMRENTQDGAQGSWFKVTIPHGKKYDKMWLMNSIQSLCSVCFTPVDFHYVKNGARFFVQKASTASALMDVSYKIYDEENQKIPIFVNPSAVPYSVRNKLRPEKMEKLKLAFNKRFDVSQQSLDLQKLRFDPNLMGHDIEIILNQRNCMAAALQIIKKNFPELLSLNLSCNKLYHLDGLSDIVHMVPTIKILNLSNNELNSMWELNKMKGLKLEELWLRGNPLCNRFPDQSTYLSAVIECFPKLLRLDGQELPSTVVTDSHPPCATKPSKENNKEPDTLKNMILQFLKQYYLIYDSGNRYGLLSAYHHKACFSLTIPFHSEDPGLSSLCAYFKDSRNMKKVKDPNLRVQQLKHTNSDIVRALCMLPKTQHDLSSFLVDMWFQTGTMLCFSVNGMFKEVEGGSQECVRAFTRTFIITPTSSSSLCIVNDELFVMEARPKNTQSAVSIPVPTPSTSSVATLSEEQQQMVQAFSTQSGMNCQWSQKCLQDNDWNYTRAGQVFCMFKTEGKIPEEAFKEIP", "length": 634, "header": "tr|A0AAA9SC18-1|A0AAA9SC18_BOVIN Isoform 1 of Nuclear RNA export factor 2 OS=Bos taurus OX=9913 GN=NXF2 PE=3 SV=1 CANONICAL=A0AAA9SC18-1" }, "locus": { "chromosome": "X", "start_pos": 50450967, "end_pos": 50431716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126222.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126222.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083650.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083650.1" } ] } }, { "isoform_ac": "G3X6I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18/entry#G3X6I2-1", "sequence": { "sequence": "MSERKHQRKNTHPTKNNGTYKNEEYRGGDSSPEGRNEGWSSFQDDFDKRSPRYEDNEYETQPSHHSDDDGSMVMRNVHEGPKERHFPYSFRGNGRRVRWRREGNICVTVWGNGKPVMRKMRENTQDGAQGSWFKVTIPHGKKYDKMWLMNSIQSLCSVCFTPVDFHYVKNGARFFVQKASTASALMDVSYKIYDEENQKIPIFVNPSAVPYSVRNKLRPEKMEKLKLAFNKRFDVSQQSLDLQKLRFDPNLMGHDIEIILNQRNCMAAALQIIKKNFPELLSLNLSCNKLYHLDGLSDIVHMVPTIKILNLSNNELNSMWELNKMKGLKLEELWLRGNPLCNRFPDQSTYLSAVIECFPKLLRLDGQELPSTVVTDSHPPCATKPSKENNKEPDTLKNMILQFLKQSSLCAYFKDSRNMKKVKDPNLRVQQLKHTNSDIVRALCMLPKTQHDLSSFLVDMWFQTGTMLCFSVNGMFKEVEGGSQECVRAFTRTFIITPTSSSSLCIVNDELFVMEARPKNTQSAVSIPVPTPSTSSVATLSEEQQQMVQAFSTQSGMNCQWSQKCLQDNDWNYTRAGQVFCMFKTEGKIPEEAFKEIP", "length": 598, "header": "tr|G3X6I2-1|G3X6I2_BOVIN Computationally mapped isoform of Nuclear RNA export factor 2 OS=Bos taurus OX=9913 GN=NXF2 PE=3 SV=3 CANONICAL=A0AAA9SC18-1" }, "locus": { "chromosome": "X", "start_pos": 50450967, "end_pos": 50431716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006996.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006996.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006996.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006996.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 567, "start_aa": "Thr", "end_pos": 567, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr567", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:613789", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613789", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 608, "end_pos": 610, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" }, { "id": "PS50177", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50177" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTF2", "eco_id": "ECO_0000259", "start_pos": 399, "end_pos": 549, "start_aa": "Met", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC18" }, { "id": "PS51281", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51281" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TAP-C", "eco_id": "ECO_0000259", "start_pos": 578, "end_pos": 633, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 567 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 17, "end_pos": 19 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 310, "end_pos": 312 }, { "start_pos": 608, "end_pos": 610 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC24-1", "uniprot_ac": "A0AAA9SC24", "uniprot_id": "A0AAA9SC24_BOVIN", "mass": { "chemical_mass": 45230.0, "monoisotopic_mass": 45230.0 }, "refseq": { "ac": "XP_024844922", "name": "melanoma-associated antigen B2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844922" }, "gene_names": [ { "name": "LOC788278", "type": "recommended", "evidence": [ { "id": "A0AAA9SC24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24" } ] }, { "name": "LOC788278", "type": "synonym", "evidence": [ { "id": "XP_024844922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844922" } ] } ], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SC24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24/entry#names_and_taxonomy" } ] }, { "name": "melanoma-associated antigen B2", "type": "synonym", "evidence": [ { "id": "XP_024844922", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844922" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC788278", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24", "locus": {} } ], "crossref": [ { "id": "A0AAA9SC24", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC24", "database": "AlphaFoldDB", "categories": [] }, { "id": "788278", "url": "https://www.ncbi.nlm.nih.gov/gene/788278", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788278", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788278", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844922", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844922", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SC24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRGQKSKHRAREKRRQARAEIQGLHDQATTSRGEETTSSSPPDSESAPSSLSAAGTPKGPPGAQGTTSAAAGAIRKRSGGGGTARSRSGVGGTARSRSGVGAEGQVQGGENSSQASAAAEISHTDLLTMESENLVKYMLLKYKMRELIKRSEMVKVIHRRYKAQFSEILSRASEHMEMVFGLVLKEVRPNSHCYTLVSNLDLSDSESMRGDWGLPKNGLLMPLLGVIYLNGHRASEEEVWKFLNILGIYDGRMHFIFGDTRKLITENLVQEEYLEYNQVPGSNPPRYEFLWGPKALTENSKTKVLQFLTKVNDLVPDALLPHYEEALREEAERTGARAATGTGPSASASADPSASARPGTSAAARAGTSASAMADMSALAGAGPLASARDGTSAAARDGTSAAARDGTSASTSAHSRATSSHSSGP", "length": 427, "header": "tr|A0AAA9SC24-1|A0AAA9SC24_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC788278 PE=4 SV=1 CANONICAL=A0AAA9SC24-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SC24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24/entry#A0AAA9SC24-1", "sequence": { "sequence": "MPRGQKSKHRAREKRRQARAEIQGLHDQATTSRGEETTSSSPPDSESAPSSLSAAGTPKGPPGAQGTTSAAAGAIRKRSGGGGTARSRSGVGGTARSRSGVGAEGQVQGGENSSQASAAAEISHTDLLTMESENLVKYMLLKYKMRELIKRSEMVKVIHRRYKAQFSEILSRASEHMEMVFGLVLKEVRPNSHCYTLVSNLDLSDSESMRGDWGLPKNGLLMPLLGVIYLNGHRASEEEVWKFLNILGIYDGRMHFIFGDTRKLITENLVQEEYLEYNQVPGSNPPRYEFLWGPKALTENSKTKVLQFLTKVNDLVPDALLPHYEEALREEAERTGARAATGTGPSASASADPSASARPGTSAAARAGTSASAMADMSALAGAGPLASARDGTSAAARDGTSAAARDGTSASTSAHSRATSSHSSGP", "length": 427, "header": "tr|A0AAA9SC24-1|A0AAA9SC24_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC788278 PE=4 SV=1 CANONICAL=A0AAA9SC24-1" }, "locus": { "chromosome": "NKLS02001410.1", "start_pos": 157244, "end_pos": 155964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132341.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132341.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081067.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081067.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788278", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788278", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC24" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 327, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC38-1", "uniprot_ac": "A0AAA9SC38", "uniprot_id": "A0AAA9SC38_BOVIN", "mass": { "chemical_mass": 40866.0, "monoisotopic_mass": 40866.0 }, "refseq": { "ac": "NP_001421915", "name": "2-Hydroxyacid oxidase 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421915" }, "gene_names": [ { "name": "HAO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] }, { "name": "HAO1", "type": "synonym", "evidence": [ { "id": "NP_001421915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421915" } ] } ], "protein_names": [ { "name": "(S)-2-hydroxy-acid oxidase", "type": "recommended", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38/entry#names_and_taxonomy" } ] }, { "name": "1.1.3.15", "type": "synonym", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38/entry#names_and_taxonomy" } ] }, { "name": "2-Hydroxyacid oxidase 1 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421915" } ] }, { "name": "hydroxyacid oxidase (glycolate oxidase) 1", "type": "synonym", "evidence": [ { "id": "NP_001421915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421915" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38", "locus": { "chromosome": "13", "start_pos": 50564456, "end_pos": 50715110, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019811", "url": "https://www.ensembl.org/id/ENSBTAG00000019811" } ] } } ], "crossref": [ { "id": "A0AAA9SC38", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019811", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019811", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02809", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02809", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533957", "url": "https://www.ncbi.nlm.nih.gov/gene/533957", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000262", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000262", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RIWFRPK", "url": "https://omabrowser.org/oma/group/RIWFRPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC79", "url": "https://www.orthodb.org/?gene=E1BC79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10578", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10578", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10578:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10578:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01070", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01070", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-389661", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389661", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421915", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16789", "url": "https://www.rhea-db.org/rhea/16789", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67940", "url": "https://www.rhea-db.org/rhea/67940", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SC38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC79", "url": "https://www.uniprot.org/uniprotkb/E1BC79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC79-1", "url": "https://www.uniprot.org/uniprotkb/E1BC79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSRLVCISDYEQHAKSVLQKSIYDYYKSGANDQETLADNIAAFSRWKLYPRMLRNIAEIDLSTSVLGQKVSMPICVGATAMQCMAHVDGELATVRACRSLGTGMMLSSWATSSIEEVAEAGPEAIRWLQLYIYKDREVTKQLVRRAERMGYKAIFVTVDTPYLGNRFDDVRNRFKMPPQLRMKNFETNDLAFSPKENFGDKSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAKAAVKHGLDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLASQGEKGVQDVLEILKEEFWLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370, "header": "tr|A0AAA9SC38-1|A0AAA9SC38_BOVIN Isoform 1 of (S)-2-hydroxy-acid oxidase OS=Bos taurus OX=9913 GN=HAO1 PE=1 SV=1 CANONICAL=A0AAA9SC38-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SC38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38/entry#A0AAA9SC38-1", "sequence": { "sequence": "MSSRLVCISDYEQHAKSVLQKSIYDYYKSGANDQETLADNIAAFSRWKLYPRMLRNIAEIDLSTSVLGQKVSMPICVGATAMQCMAHVDGELATVRACRSLGTGMMLSSWATSSIEEVAEAGPEAIRWLQLYIYKDREVTKQLVRRAERMGYKAIFVTVDTPYLGNRFDDVRNRFKMPPQLRMKNFETNDLAFSPKENFGDKSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAKAAVKHGLDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLASQGEKGVQDVLEILKEEFWLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370, "header": "tr|A0AAA9SC38-1|A0AAA9SC38_BOVIN Isoform 1 of (S)-2-hydroxy-acid oxidase OS=Bos taurus OX=9913 GN=HAO1 PE=1 SV=1 CANONICAL=A0AAA9SC38-1" }, "locus": { "chromosome": "13", "start_pos": 50715076, "end_pos": 50652817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100132.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100132.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081082.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081082.1" } ] } }, { "isoform_ac": "E1BC79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38/entry#E1BC79-1", "sequence": { "sequence": "MSSRLVCISDYEQHAKSVLQKSIYDYYKSGANDQETLADNIAAFSRWKLYPRMLRNIAEIDLSTSVLGQKVSMPICVGATAMQCMAHVDGELATVRACRSLGTGMMLSSWATSSIEEVAEAGPEAIRWLQLYIYKDREVTKQLVRRAERMGYKAIFVTVDTPYLGNRFDDVRNRFKMPPQLRMKNFETNDLAFSPKENFGDKSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAKAAVKHGLDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLASQGEKGVQDVLEILKEEFWLAMALSGCQNVKVIDKTLKADTCEEERHQSSSDSFSCLSMMVKTWL", "length": 387, "header": "tr|E1BC79-1|E1BC79_BOVIN Computationally mapped isoform of (S)-2-hydroxy-acid oxidase OS=Bos taurus OX=9913 GN=HAO1 PE=1 SV=3 CANONICAL=A0AAA9SC38-1" }, "locus": { "chromosome": "13", "start_pos": 50715076, "end_pos": 50564502, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061291.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061291.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053733.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053733.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-389661", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389661", "resource": "Reactome", "description": "Glyoxylate metabolism and glycine degradation" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QIP9-1", "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "Hao1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLLRLVCINDYEEHARSVLQKSVYDYYKSGANDQETLADNIRAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICAGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREVSRQLVKRAEKMGYKAIFVTVDTPYLGNRFDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVTQAIDPSLSWDDIKWLRRLTSLPIVVKGILRGDDAREAVKHGVDGILVSNHGARQLDGVPATIDALPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B0BNF9-1", "protein_name": "2-Hydroxyacid oxidase 1", "gene_name": "Hao1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPRLVCISDYEQHARTVLQKSVYDYYKSGANDQETLADNIRAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREVSSQLVKRAEQMGYKAIFVTVDTPYLGNRFDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDIKWLRRLTSLPIVVKGILRGDDAQEAVKHGVDGILVSNHGARQLDGVPATIDALPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGARAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BRR7-1", "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "HAO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGKPVCVADFEHYAKTFLPKSVYDYYRSGADDQETLADNVAAFSRWKLYPRVLRDVSVMDLSTSVLGQKISMPVCVAATAMQRMAHPDGETATAKACHAMGTGMMLSSWATSSIEEVAEAAPGGLRWLQLYVYKDREVTKSLVKRAERAGYKGIFVTVDTPFLGRRIDDVRNKFQLPPHLRLKNFSSNNLDFSGRDFGEDSGLAVYVANAIDASVNWEDIKWLRGLTSLPIVAKGILRADDAKEAVKLGVDGILVSNHGARQLDGVPATIDILPEIVEAVEGKVEVFLDGGIRKGTDILKALALGAKAVFIGRPLIWGLVYQGEEGAKEVLQMLKEEFRLAMALTGCRTVKEIGRTLIRRHEVLLSKI", "length": 369 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LVF1-1", "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "HAO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFTRLVCISDYEQHAKSILQKSIYDYYKSGANDQETLADNIAAFSRWKLYPRMLRNVAEVDLSTSVLGQRVSMPICVGATAMQCMAHEDGELATVRACRTLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKQLVQRAERMGYKAIFVTVDTPYLGNRFDDVRNRFKLPSQLRMKNFETNDLAFSPKENFGDNSGLAAYVAKAIDPSISWEDIKWLRRLTTLPIVAKGILRGDDAKEVVKHGLDGILVSNHGARQLDGVPATIDALPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLASQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P00175-1", "protein_name": "L-lactate dehydrogenase (cytochrome)", "gene_name": "CYB2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLKYKPLLKISKNCEAAILRASKTRLNTIRAYGSTVPKSKSFEQDSRKRTQSWTALRVGAILAATSSVAYLNWHNGQIDNEPKLDMNKQKISPAEVAKHNKPDDCWVVINGYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKKLGPLQGSMPPELVCPPYAPGETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGANDEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATALCKLGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFSNTKAGPKAMKKTNVEESQGASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVLSNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA", "length": 591 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54E41-1", "protein_name": "2-Hydroxyacid oxidase", "gene_name": "haox", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENQFKNNNNSSSIETSNQFSNKKTNRLDSFVSVSELHEEAKRLLPKMAYDYYASGSNDQITLAENENAFSRIKLVPRSLVDVSKVNTKTRIFGRDISTPILIAPWAMQRMASQRGELDTVEASKEFNTIMTLSSLSTTSVEDLSSATNGNPGWFQLYVFKDRKVSEELVKRAESIGYSALVLTVDTPFLGKRTADFKNSFKLPNGLSLKIFEKLMLSNLDGGLNQYIATMIDPSLTWNDLKWLKSITKLPILVKGIMCPKDAELALQYGADGIIVSNHGGRQLDTCPSTIEVLPYISKVVRGRVPLILDGGIRRGTDVLKALAFGANAVCIGRPIIWGLSTGGKDGVLKVLNLLNSELQLAMALTGITNISDINNSIIWDQNKYIKL", "length": 388 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9LRR9-1", "protein_name": "Glycolate oxidase 1", "gene_name": "GLO1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEITNVTEYDAIAKQKLPKMVYDYYASGAEDQWTLQENRNAFARILFRPRILIDVSKIDMTTTVLGFKISMPIMVAPTAMQKMAHPDGEYATARAASAAGTIMTLSSWATSSVEEVASTGPGIRFFQLYVYKNRNVVEQLVRRAERAGFKAIALTVDTPRLGRRESDIKNRFTLPPNLTLKNFEGLDLGKMDEANDSGLASYVAGQIDRTLSWKDVQWLQTITKLPILVKGVLTGEDARIAIQAGAAGIIVSNHGARQLDYVPATISALEEVVKATQGRIPVFLDGGVRRGTDVFKALALGASGIFIGRPVVFSLAAEGEAGVRKVLQMLRDEFELTMALSGCRSLKEISRNHITTEWDTPRPSARL", "length": 367 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UJM8-1", "protein_name": "2-Hydroxyacid oxidase 1", "gene_name": "HAO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WU19-1", "protein_name": "2-Hydroxyacid oxidase 1", "gene_name": "Hao1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPRLVCISDYEQHVRSVLQKSVYDYYRSGANDQETLADNIQAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREISRQIVKRAEKQGYKAIFVTVDTPYLGNRIDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDITWLRRLTSLPIVVKGILRGDDAKEAVKHGVDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI", "length": 370 }, "evidence": [ { "id": "A0AAA9SC38", "url": "https://omabrowser.org/oma/group/A0AAA9SC38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "FMN binding", "id": "GO:0010181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010181", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ], "pmid": "" }, { "name": "(S)-2-hydroxy-acid oxidase activity", "id": "GO:0003973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003973", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16789", "name": "", "equation": "a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SC38-1", "Q3ZBW2-1" ], "evidence": [ { "id": "16789", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16789" } ] }, { "id": "67940", "name": "", "equation": "2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SC38-1", "Q3ZBW2-1" ], "evidence": [ { "id": "67940", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67940" } ] }, { "id": "R-BTA-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-389822" ], "output_participant_list": [], "enzyme_list": [ "A0AAA9SC38-1" ], "evidence": [ { "id": "R-BTA-389842", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389842" } ] }, { "id": "R-BTA-389862", "name": "Conversion of glyoxylate to oxalate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-389678" ], "output_participant_list": [ "R-ALL-389819" ], "enzyme_list": [ "A0AAA9SC38-1" ], "evidence": [ { "id": "R-BTA-389862", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389862" } ] }, { "id": "R-BTA-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033235" } ] }, { "id": "R-BTA-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033236" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-389678", "participant_name": "glyoxylate [peroxisomal matrix]", "crossref": [ { "id": "36655", "database": "ChEBI", "url": "" }, { "id": "ZINC000004658554", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-389819", "participant_name": "OX [peroxisomal matrix]", "crossref": [ { "id": "144-62-7", "database": "CAS", "url": "" }, { "id": "4538", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "71081", "database": "PubChem Compound", "url": "" }, { "id": "30623", "database": "ChEBI", "url": "" }, { "id": "C00209", "database": "KEGG Gene", "url": "" }, { "id": "OXALATE", "database": "AraCyc", "url": "" } ] }, { "participant_id": "R-ALL-389822", "participant_name": "glycolate [peroxisomal matrix]", "crossref": [ { "id": "29805", "database": "ChEBI", "url": "" }, { "id": "79-14-1", "database": "CAS", "url": "" }, { "id": "5460308", "database": "PubChem Compound", "url": "" }, { "id": "C00160", "database": "KEGG Gene", "url": "" }, { "id": "GLYCOLLATE", "database": "AraCyc", "url": "" }, { "id": "ZINC000004658557", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LQH8", "gene_name": "GNPAT", "activity": [ { "ec_number": "2.3.1.42", "activity": "dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LTU2", "gene_name": "PEX10", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LYY4", "gene_name": "CRAT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] } ] }, { "uniprot_ac": "A0AAA9SAI8", "gene_name": "TYSND1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "A0AAA9SAI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI8" } ] } ] }, { "uniprot_ac": "A0AAA9SC38", "gene_name": "HAO1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] } ] }, { "uniprot_ac": "A0AAA9SND8", "gene_name": "EHHADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] } ] }, { "uniprot_ac": "A0AAA9SXG3", "gene_name": "DAO", "activity": [ { "ec_number": "1.4.3.3", "activity": "D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+).", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] } ] }, { "uniprot_ac": "A0AAA9TBR3", "gene_name": "PAOX", "activity": [ { "ec_number": "1.5.3.13", "activity": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2.", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] }, { "ec_number": "1.5.3.13", "activity": "", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TYP4", "gene_name": "PECR", "activity": [ { "ec_number": "1.3.1.38", "activity": "a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+).", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] }, { "ec_number": "1.3.1.38", "activity": "", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] } ] }, { "uniprot_ac": "A0AAA9TZC7", "gene_name": "ECI2", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "F1MV74", "gene_name": "SCP2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] } ] }, { "uniprot_ac": "F1MVP8", "gene_name": "HACL1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] } ] }, { "uniprot_ac": "F1MYR5", "gene_name": "NOS2", "activity": [ { "ec_number": "1.14.13.39", "activity": "2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O.", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] } ] }, { "uniprot_ac": "F6RWU6", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "succinyl-CoA + H2O = succinate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] } ] }, { "uniprot_ac": "O19094", "gene_name": "CROT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "Q24K02", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] } ] }, { "uniprot_ac": "Q29448", "gene_name": "HMGCL", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] } ] }, { "uniprot_ac": "Q29RU9", "gene_name": "PIPOX", "activity": [ { "ec_number": "1.5.3.1", "activity": "sarcosine + O2 + H2O = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+).", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] } ] }, { "uniprot_ac": "Q3SX23", "gene_name": "LONP2", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] }, { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] } ] }, { "uniprot_ac": "Q3SZP5", "gene_name": "ACOX1", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "Q3SZP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZP5" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "Q3SZP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZP5" } ] } ] }, { "uniprot_ac": "Q3ZBW2", "gene_name": "HAO2", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" }, { "id": "PS51349", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51349" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FMN hydroxy acid dehydrogenase", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 365, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.3.15", "ec_name": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "1.1.3.15", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15" }, { "id": "1.1.3.15", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.3.15" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC54-1", "uniprot_ac": "A0AAA9SC54", "uniprot_id": "A0AAA9SC54_BOVIN", "mass": { "chemical_mass": 14285.0, "monoisotopic_mass": 14285.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ubiquitin-like protein ATG12", "type": "recommended", "evidence": [ { "id": "A0AAA9SC54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ubiquitin-like protein involved in autophagic vesicle formation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54#function" }, { "database": "UniProtKB", "id": "RU361201", "url": "https://www.uniprot.org/uniprotkb/RU361201#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54", "locus": {} } ], "crossref": [ { "id": "A0AAA9SC54", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC54", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13385:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13385:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SC54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEESALQFPPSTAPEAEGPKEVSPETATPEPTSSATVSLGTEEPVADTKKKSNILLKAVGDTPIMKTKKWAVERTQTIQGLIDFIKKFLKLVASEQPLLNNSLGPMESESVPKETLSPCGPLFLGTIGFSDTL", "length": 134, "header": "tr|A0AAA9SC54-1|A0AAA9SC54_BOVIN Isoform 1 of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SC54-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SC54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54/entry#A0AAA9SC54-1", "sequence": { "sequence": "MAEESALQFPPSTAPEAEGPKEVSPETATPEPTSSATVSLGTEEPVADTKKKSNILLKAVGDTPIMKTKKWAVERTQTIQGLIDFIKKFLKLVASEQPLLNNSLGPMESESVPKETLSPCGPLFLGTIGFSDTL", "length": 134, "header": "tr|A0AAA9SC54-1|A0AAA9SC54_BOVIN Isoform 1 of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SC54-1" }, "locus": { "chromosome": "15", "start_pos": 31629499, "end_pos": 31628233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120339.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120339.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079811.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079811.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC54" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC75-1", "uniprot_ac": "A0AAA9SC75", "uniprot_id": "A0AAA9SC75_BOVIN", "mass": { "chemical_mass": 36542.0, "monoisotopic_mass": 36542.0 }, "refseq": {}, "gene_names": [ { "name": "MFNG", "type": "recommended", "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ] } ], "protein_names": [ { "name": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.222", "type": "synonym", "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75/entry#names_and_taxonomy" } ] }, { "name": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFNG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75", "locus": { "chromosome": "5", "start_pos": 75879294, "end_pos": 75903492, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015043", "url": "https://www.ensembl.org/id/ENSBTAG00000015043" } ] } } ], "crossref": [ { "id": "A0AAA9SC75", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC75", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10811", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10811", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "70511", "url": "https://www.rhea-db.org/rhea/70511", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70531", "url": "https://www.rhea-db.org/rhea/70531", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6C9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQCRLLRGLAGVLLTLLCMGLLSLRYRSSPSPQRVPDTPELSPPSPRPSELQLHDVFIAVKTTQAFHHSRLELLLNTWVSRTREQTFIFTDSPDEGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDAFLASGLRWFCHVDDDNYLNPRALLKLLKTFPQTRDVYVGRPSLNRPIHASEPQPHNRTKLVQFWFATGGAGFCINRKLALKMAPWASGSHFMDTSALIRLPDDCTVGYIVECKLGGHLQSCPLFHSHLETLQLLEAAQLPEQVTLSYGVFEGKLNVIKLHGPFSPEEDPSRVHHEKRWTGRNTSWNQDCREKYQ", "length": 323, "header": "tr|A0AAA9SC75-1|A0AAA9SC75_BOVIN Isoform 1 of O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MFNG PE=3 SV=1 CANONICAL=A0AAA9SC75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SC75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75/entry#A0AAA9SC75-1", "sequence": { "sequence": "MQCRLLRGLAGVLLTLLCMGLLSLRYRSSPSPQRVPDTPELSPPSPRPSELQLHDVFIAVKTTQAFHHSRLELLLNTWVSRTREQTFIFTDSPDEGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDAFLASGLRWFCHVDDDNYLNPRALLKLLKTFPQTRDVYVGRPSLNRPIHASEPQPHNRTKLVQFWFATGGAGFCINRKLALKMAPWASGSHFMDTSALIRLPDDCTVGYIVECKLGGHLQSCPLFHSHLETLQLLEAAQLPEQVTLSYGVFEGKLNVIKLHGPFSPEEDPSRVHHEKRWTGRNTSWNQDCREKYQ", "length": 323, "header": "tr|A0AAA9SC75-1|A0AAA9SC75_BOVIN Isoform 1 of O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MFNG PE=3 SV=1 CANONICAL=A0AAA9SC75-1" }, "locus": { "chromosome": "5", "start_pos": 75903318, "end_pos": 75880298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105277.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105277.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081123.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081123.1" } ] } }, { "isoform_ac": "A0AAA9T6C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75/entry#A0AAA9T6C9-1", "sequence": { "sequence": "MQCRLLRGLAGVLLTLLCMGLLSLRYRSSPSPQRVPDTPELSPPSPRPSELQLHDVFIAVKTTQAFHHSRLELLLNTWVSRTREQTFIFTDSPDEGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDAFLASGLRWFCHVDDDNYLNPRALLKLLKTFPQTRDVYVGRPSLNRPIHASEPQPHNRTKLVQFWFATGGAGFCINRKLALKMAPWASGSHFMDTSALIRLPDDCTVGYIVECKLGGHLQSCPLFHSHLETLQLLEAAQLPEQVTLSYGVFEGKLNVIKLHGPFSPEEDPSR", "length": 300, "header": "tr|A0AAA9T6C9-1|A0AAA9T6C9_BOVIN Computationally mapped isoform of O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase OS=Bos taurus OX=9913 GN=MFNG PE=3 SV=1 CANONICAL=A0AAA9SC75-1" }, "locus": { "chromosome": "5", "start_pos": 75903318, "end_pos": 75882232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117411.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117411.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093435.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093435.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ], "pmid": "" }, { "name": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "id": "GO:0033829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "marginal zone B cell differentiation", "id": "GO:0002315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ], "pmid": "" }, { "name": "regulation of Notch signaling pathway", "id": "GO:0008593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "70511", "name": "", "equation": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJ92-1", "F1MQG2-1", "A0AAA9SC75-1" ], "evidence": [ { "id": "70511", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70511" } ] }, { "id": "70531", "name": "", "equation": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJ92-1", "F1MQG2-1", "A0AAA9SC75-1" ], "evidence": [ { "id": "70531", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70531" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SC75", "gene_name": "MFNG", "activity": [ { "ec_number": "2.4.1.222", "activity": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ] }, { "ec_number": "2.4.1.222", "activity": "", "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" } ] } ] }, { "uniprot_ac": "F1MQG2", "gene_name": "RFNG", "activity": [ { "ec_number": "2.4.1.222", "activity": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "F1MQG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQG2" } ] }, { "ec_number": "2.4.1.222", "activity": "", "evidence": [ { "id": "F1MQG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQG2" } ] } ] }, { "uniprot_ac": "Q2KJ92", "gene_name": "LFNG", "activity": [ { "ec_number": "2.4.1.222", "activity": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "Q2KJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ92" } ] }, { "ec_number": "2.4.1.222", "activity": "", "evidence": [ { "id": "Q2KJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ92" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC75" }, { "id": "PF02434", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02434" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fringe-like glycosyltransferase", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 300, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G01002UX", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G01758EA", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G01854VF", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G09106ES", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G10016UC", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G17931GP", "type": "O-linked", "subtype": "O-fucose core 2" }, { "glytoucan_ac": "G17988BN", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G19968XU", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G21971UP", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G26238GL", "type": "O-linked", "subtype": "O-fucose core 2" }, { "glytoucan_ac": "G30868KJ", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G34964CV", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G39294YF", "type": "O-linked", "subtype": "O-fucose core 2" }, { "glytoucan_ac": "G47722SQ", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G48998UF", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G54574KG", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G60605ZN", "type": "O-linked", "subtype": "O-fucose core 2" }, { "glytoucan_ac": "G70593HA", "type": "O-linked", "subtype": "O-fucose core 2" }, { "glytoucan_ac": "G85661BQ", "type": "O-linked", "subtype": "O-fucose core, other" } ], "enzyme_annotation": [ { "ec_number": "2.4.1.222", "ec_name": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "2.4.1.222", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222" }, { "id": "2.4.1.222", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.222" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 311, "end_pos": 313 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC85-1", "uniprot_ac": "A0AAA9SC85", "uniprot_id": "A0AAA9SC85_BOVIN", "mass": { "chemical_mass": 88790.0, "monoisotopic_mass": 88790.0 }, "refseq": { "ac": "XP_005219104", "name": "centrosomal protein of 89 kDa isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219104" }, "gene_names": [ { "name": "CEP89", "type": "recommended", "evidence": [ { "id": "A0AAA9SC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ] }, { "name": "CEP89", "type": "synonym", "evidence": [ { "id": "XP_005219104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219104" } ] } ], "protein_names": [ { "name": "Centrosomal protein 89", "type": "synonym", "evidence": [ { "id": "A0AAA9SC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 89 kDa isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005219104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219104" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85", "locus": { "chromosome": "18", "start_pos": 43315273, "end_pos": 43398182, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004864", "url": "https://www.ensembl.org/id/ENSBTAG00000004864" } ] } } ], "crossref": [ { "id": "A0AAA9SC85", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC85", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004864", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004864", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512749", "url": "https://www.ncbi.nlm.nih.gov/gene/512749", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ENQQMRE", "url": "https://omabrowser.org/oma/group/ENQQMRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNK9", "url": "https://www.orthodb.org/?gene=A0A3Q1MNK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MIX9", "url": "https://www.orthodb.org/?gene=F1MIX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36170:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36170:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005219104", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219104", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNK9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNK9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIX9", "url": "https://www.uniprot.org/uniprotkb/F1MIX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIX9-1", "url": "https://www.uniprot.org/uniprotkb/F1MIX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLGFRRGHKRKYKHIIHGLLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILSTTLTGRTVAIPQPRRRAHSESDMTSMEKDSLIEPYATTSELRHQPHWQNETGRRSSLPSFEMLGYEEDEDTDSHLSSSRRQSGDASACKEEGSLCDATYATPHRNQVPSSHGVDTEDEESISEQDGFPGSPIPPENTQGKDGKHSVLKLKDEKPPLCEKPPLCPDITGRTRQRCIEITKEKLEELKEENLHLNNANQALTHELNIIKKTMKDLQLKLERMKKENVKPKEVEKASSQEVVAAPELHYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKKESLNIEGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDELIASLQEEMRVFRIRAQEVVKENEKLHQELNKSSPVTNEEWRQLQTQAELVLEENKLLIEQLEIQQRKAKDTHRERLQEVSKLTKQLMLLETKTQSQEKELTESKEQLAILRTECQELQIQLDSKVAMEVHTSIVNEFKSQLQKEEEKENAEMEELMEKLAALQVQKKSLLLEKKNLMAKNKALEAELEKAQKINRRSQKKIDVLKKQVEKAMENEMSAHQYLANLVGLAENVTQERDNLVFLAKCLESENHGVLNRMTEDSIRLGRLKEKIKGYKKQMALKLDDMNHHLTEQQEDFASKSAQYQQEMRHLHRMLLDKQDILDKALQQKREVEGELEVVWESTSKENRRIRELLQATLERTGPWENTRVSEDHCLDVISQQAMLDAVT", "length": 771, "header": "tr|A0AAA9SC85-1|A0AAA9SC85_BOVIN Isoform 1 of Centrosomal protein 89 OS=Bos taurus OX=9913 GN=CEP89 PE=4 SV=1 CANONICAL=A0AAA9SC85-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MNK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85/entry#A0A3Q1MNK9-1", "sequence": { "sequence": "MLLGFRRGHKRKYKHIIHGLLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILSTTLTGRTVAIPQPRRRAHSESDMTSMEKDSLIEPYATTSELRHQPHWQNETGRRSSLPSFEMLGYEEDEDTDSHLSSSRRQSGDASACKEEGSLCDATYATPHRNQVPSSHGVDTEDEESISEQDGFPGSPIPPENTQGKDGKHSVLKLKDEKPPLCEKPPLCPDITGRTRQRCIEITKEKLEELKEENLHLNNANQALTHELNIIKKTMKDLQLKLERMKKENVKPKEVEKASSQEVVAAPELHYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKKESLNIEGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDELIASLQEEMRVFRIRAQEVVKENEKLHQELNKSSPVTNEEWRQLQTQAELVLEENKLLIEQLEIQQRKAKDTHRERLQEVSKLTKQLMLLETKTQSQEKELTESKEQLAILRTECQELQIQLDSKVAMEVHTSIVNEFKSQLQKEEEKENAEMEELMEKLAALQVQKKSLLLEKKNLMAKNKALEAELEKAQKINRRSQKKIDVLKKQVEKAMENEMSAHQYLANLVGLAENVTQERDNLVFLGYKKQMALKLDDMNHHLTEQQEDFASKSAQYQQEMRHLHRMLLDKQDILDKALQQKREVEGELEVVWESTSKENRRIRELLQATLERTGPWENTRVSEDHCLDVISQQAMLDAVT", "length": 741, "header": "tr|A0A3Q1MNK9-1|A0A3Q1MNK9_BOVIN Computationally mapped isoform of Centrosomal protein 89 OS=Bos taurus OX=9913 GN=CEP89 PE=4 SV=1 CANONICAL=A0AAA9SC85-1" }, "locus": { "chromosome": "18", "start_pos": 43398104, "end_pos": 43316277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075824.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075824.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072848.1" } ] } }, { "isoform_ac": "A0AAA9SC85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85/entry#A0AAA9SC85-1", "sequence": { "sequence": "MLLGFRRGHKRKYKHIIHGLLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILSTTLTGRTVAIPQPRRRAHSESDMTSMEKDSLIEPYATTSELRHQPHWQNETGRRSSLPSFEMLGYEEDEDTDSHLSSSRRQSGDASACKEEGSLCDATYATPHRNQVPSSHGVDTEDEESISEQDGFPGSPIPPENTQGKDGKHSVLKLKDEKPPLCEKPPLCPDITGRTRQRCIEITKEKLEELKEENLHLNNANQALTHELNIIKKTMKDLQLKLERMKKENVKPKEVEKASSQEVVAAPELHYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKKESLNIEGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDELIASLQEEMRVFRIRAQEVVKENEKLHQELNKSSPVTNEEWRQLQTQAELVLEENKLLIEQLEIQQRKAKDTHRERLQEVSKLTKQLMLLETKTQSQEKELTESKEQLAILRTECQELQIQLDSKVAMEVHTSIVNEFKSQLQKEEEKENAEMEELMEKLAALQVQKKSLLLEKKNLMAKNKALEAELEKAQKINRRSQKKIDVLKKQVEKAMENEMSAHQYLANLVGLAENVTQERDNLVFLAKCLESENHGVLNRMTEDSIRLGRLKEKIKGYKKQMALKLDDMNHHLTEQQEDFASKSAQYQQEMRHLHRMLLDKQDILDKALQQKREVEGELEVVWESTSKENRRIRELLQATLERTGPWENTRVSEDHCLDVISQQAMLDAVT", "length": 771, "header": "tr|A0AAA9SC85-1|A0AAA9SC85_BOVIN Isoform 1 of Centrosomal protein 89 OS=Bos taurus OX=9913 GN=CEP89 PE=4 SV=1 CANONICAL=A0AAA9SC85-1" }, "locus": { "chromosome": "18", "start_pos": 43398104, "end_pos": 43316277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110995.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110995.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083736.1" } ] } }, { "isoform_ac": "F1MIX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85/entry#F1MIX9-1", "sequence": { "sequence": "MLLGFRRGHKRKYKHIIHGLLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILSTTLTGRTVAIPQPRRRAHSESDMTSMEKDSLIEPYATTSELRHQPHWQNETGRRSSLPSFEMLGYEEDEDTDSHLSSSRRQSGDASACKEEGSLCDATYATPHRNQVPSSHGVDTEDEESISEQDGFPGSPIPPENTQGKDITGRTRQRCIEITKEKLEELKEENLHLNNANQALTHELNIIKKTMKDLQLKLERMKKENVKPKEVEKASSQEVVAAPELHYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKKESLNIEGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDELIASLQEEMRVFRIRAQEVVKENEKLHQELNKSSPVTNEEWRQLQTQAELVLEENKLLIEQLEIQQRKAKDTHRERLQEVSKLTKQLMLLETKTQSQEKELTESKEQLAILRTECQELQIQLDSKVAMEVHTSIVNEFKSQLQKEEEKENAEMEELMEKLAALQVQKKSLLLEKKNLMAKNKALEAELEKAQKINRRSQKKIDVLKKQVEKAMENEMSAHQYLANLVGLAENVTQERDNLVFLAKCLESENHGVLNRMTEDSIRLGRLKEKIKGYKKQMALKLDDMNHHLTEQQEDFASKSAQYQQEMRHLHRMLLDKQDILDKALQQKREVEGELEVVWESTSKENRRIRELLQATLERTGPWENTRVSEDHCLDVISQQAMLDAVT", "length": 747, "header": "tr|F1MIX9-1|F1MIX9_BOVIN Computationally mapped isoform of Centrosomal protein 89 OS=Bos taurus OX=9913 GN=CEP89 PE=4 SV=4 CANONICAL=A0AAA9SC85-1" }, "locus": { "chromosome": "18", "start_pos": 43398104, "end_pos": 43316277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006395.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006395.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006395.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006395.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 357, "start_aa": "Thr", "end_pos": 357, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr357", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZG8-1", "protein_name": "Centrosomal protein 89", "gene_name": "Cep89", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLSFRRNRRSQFNHIIHGFLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILATTLTGQTVAIPQPRQRSRSESDASQVEKDSFIEPYATTSELRLRQSWQNEPKRTSLPSFETLGYREDEDAETQVSSSCRESESTTWKDVGDGRGAAYAVPLRRQRKVSSSQKLVRKGDASEQDWLSDSSSSSSTPQDTQQKDVKPSVPNLEDEKVPLCKKTPPSPDVAGRIHQRYTKITKEKFDELKEETVHLYTANQALSLELSTLRQAMKDLQLKLKIVEKDNRKLKETEKASSQEVVTPELLCLRKQSQDLVDENEGLKMIIHRLNVELSRYQTKFRPLSEEESSYIEGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDKLSTALEEEMKTFRLRVQEVVRENEGLHQELTKRSPVTIEEWRQLQTQAELVLDENKLLIEQLEIQQTKAKDTQQAHLRDVSKLTKQLVLLEAKTQSQEKQLMESKEQLESLEARCRELKTQLDSKIAPDVHTSIVNELKSQLQKEEEKDSAEMEELMGKLTALQVQKKSLLLEKSSWATSNRALEAELELTRKANRRYQKKIGVLRKQVEKAMGKEMSAHQYLANLVGLAENVTKERDSLKYLAQCLEIEKHGVLNKILKGNIRLGRLEERVKGYKKQAALKLGDIHHRLMEQQDDFAGKAAQYQKEVKHLHHMLQRKQEVLDEALQQKRNMEGELEMVLESTAKENRRMRGLLQAALQRKGIQCATAPQDTCLSRLSQGDLLIGHDFSYGDVQLPATRVCQSLGESVA", "length": 792 }, "evidence": [ { "id": "A0AAA9SC85", "url": "https://omabrowser.org/oma/group/A0AAA9SC85/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96ST8-1", "protein_name": "Centrosomal protein of 89 kDa", "gene_name": "CEP89", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATTLTGRTVAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFETLDYGDEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAPSLNGVSQADLLDGCDVCSYDLKSHAPTC", "length": 783 }, "evidence": [ { "id": "A0AAA9SC85", "url": "https://omabrowser.org/oma/group/A0AAA9SC85/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZX2-1", "protein_name": "Centrosomal protein of 89 kDa", "gene_name": "Cep89", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLSFRRNRRSQFNHIIHGFLPAASIAPKPAVPRTPPPRSPNPSPERPRSALAAAILATTLTGQTVAIPQPRQRSRSESDASDIEKDSFIKPYATTSELRLRQSWQNEPRRTSLPSFEMLGYGEDEDAETQVSTSCRESESTWKDVGDGRDATYTVPHRDQVLPSQKLVRKDDAPQPDWLSDSSSSSSSSTPQHTQQKDVKHSVLNLEGEKVRLHEKPPPSPDVAGRIHQRYTEITKEKFAELKEETVHLYSANQALSCELSALRQAMKDLQLKLKLVEKDNRKLKETEKASCQEGVTPELLCLRKQSQDLVDENEGLKMIVHRLNVELSRYQTKFRPLSEEESSHIQGLPSKGPTPPWLVDIKYLSPLLLAYEDRMKEKDKLSTALEEEMKTFRLRVQEVVKENEALHQELTKRSPVTVEEWRQLQTQAELVLDENKLLIEQLEIQQAKARDTHQAHLQDVSKLTKQLVLLEAKTQGQEKQLVESTEQLESLQAKCTELKAQLDSKIAVDVHTSIVNELKSQLQKEEEKDSAEMEELMAKLTALQVQKKSLLLEKSSWATRNRALEAELERTRKANRRYQKRIDVLRKQVEKAMGKEMSAHQYLANLVGLAETVTKERDSLKYLAQCLESEKHGVLNKILKGNIRLGKLEERVKGYKKQAALKLGDIHHRLKEQQEDFAGKAAQYQKEVKHLHRMLQEKQEVLDEALQQKRNMEGELEMVLESTAKENRRMRSLLQATLERRSTQHVTAPPDTCLRRSSQGDLLIGHDFSYGDVQLLATTNRQSLGESMA", "length": 791 }, "evidence": [ { "id": "A0AAA9SC85", "url": "https://omabrowser.org/oma/group/A0AAA9SC85/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "ciliary transition fiber", "id": "GO:0097539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 357 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 414, "end_pos": 416 }, { "start_pos": 615, "end_pos": 617 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SC92-1", "uniprot_ac": "A0AAA9SC92", "uniprot_id": "A0AAA9SC92_BOVIN", "mass": { "chemical_mass": 27651.0, "monoisotopic_mass": 27651.0 }, "refseq": {}, "gene_names": [ { "name": "CHCHD10", "type": "recommended", "evidence": [ { "id": "A0AAA9SC92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92" } ] } ], "protein_names": [ { "name": "Coiled-coil-helix-coiled-coil-helix domain containing 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SC92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHCHD10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92", "locus": { "chromosome": "17", "start_pos": 71225791, "end_pos": 71228017, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022032", "url": "https://www.ensembl.org/id/ENSBTAG00000022032" } ] } } ], "crossref": [ { "id": "A0AAA9SC92", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SC92", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR010625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13523:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13523:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06747", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06747", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SC92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRGSRSVASRPASRPAAPSAAHPPAHPPPSAAAPAPAPSGQPGLMAQMATTAAGVAVGSAVGHVVGSALTGAFSGGSSEPAQPAAQQAPERAAPQPLQMGPCAYEIRQFLDCSTTQSDLTLCEGFSEALKQCKYNHGERLLPDWRQGGKGGPRLPLLRGAPAIPRCSCTSHVLPILPGAPSPPGCSFASQVLPLLPGAPAPPGGSCTFGLTSSLYRSELPALRDQSRLGGQPCTHLHPPPTDSRTMTSDCTHRAGTQSEEGVPHPTDDLR", "length": 271, "header": "tr|A0AAA9SC92-1|A0AAA9SC92_BOVIN Isoform 1 of Coiled-coil-helix-coiled-coil-helix domain containing 10 OS=Bos taurus OX=9913 GN=CHCHD10 PE=4 SV=1 CANONICAL=A0AAA9SC92-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SC92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92/entry#A0AAA9SC92-1", "sequence": { "sequence": "MPRGSRSVASRPASRPAAPSAAHPPAHPPPSAAAPAPAPSGQPGLMAQMATTAAGVAVGSAVGHVVGSALTGAFSGGSSEPAQPAAQQAPERAAPQPLQMGPCAYEIRQFLDCSTTQSDLTLCEGFSEALKQCKYNHGERLLPDWRQGGKGGPRLPLLRGAPAIPRCSCTSHVLPILPGAPSPPGCSFASQVLPLLPGAPAPPGGSCTFGLTSSLYRSELPALRDQSRLGGQPCTHLHPPPTDSRTMTSDCTHRAGTQSEEGVPHPTDDLR", "length": 271, "header": "tr|A0AAA9SC92-1|A0AAA9SC92_BOVIN Isoform 1 of Coiled-coil-helix-coiled-coil-helix domain containing 10 OS=Bos taurus OX=9913 GN=CHCHD10 PE=4 SV=1 CANONICAL=A0AAA9SC92-1" }, "locus": { "chromosome": "17", "start_pos": 71227818, "end_pos": 71226064, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096785.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096785.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083001.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083001.1" } ] } }, { "isoform_ac": "A0AAA9TIV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92/entry#A0AAA9TIV2-1", "sequence": { "sequence": "MPRGSRSVASRPARPRSAPPRSPCRWGPVPMRSGSSWTAPPPRATPCVRASARP", "length": 54, "header": "tr|A0AAA9TIV2-1|A0AAA9TIV2_BOVIN Computationally mapped isoform of Coiled-coil-helix-coiled-coil-helix domain containing 10 OS=Bos taurus OX=9913 GN=CHCHD10 PE=4 SV=1 CANONICAL=A0AAA9SC92-1" }, "locus": { "chromosome": "17", "start_pos": 71227818, "end_pos": 71226489, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096690.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096690.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096166.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 242, "start_aa": "Thr", "end_pos": 242, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr242", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SC92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SC92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC92" }, { "id": "PF06747", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06747" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CHCH", "eco_id": "ECO_0000259", "start_pos": 103, "end_pos": 135, "start_aa": "Cys", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 242 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCC2-1", "uniprot_ac": "A0AAA9SCC2", "uniprot_id": "A0AAA9SCC2_BOVIN", "mass": { "chemical_mass": 862787.0, "monoisotopic_mass": 862787.0 }, "refseq": {}, "gene_names": [ { "name": "DST", "type": "recommended", "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ] } ], "protein_names": [ { "name": "Dystonin", "type": "recommended", "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#names_and_taxonomy" } ] }, { "name": "Bullous pemphigoid antigen 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#names_and_taxonomy" } ] }, { "name": "Dystonia musculorum protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#names_and_taxonomy" } ] }, { "name": "Hemidesmosomal plaque protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2#function" }, { "database": "UniProtKB", "id": "ARBA00054620", "url": "https://www.uniprot.org/uniprotkb/ARBA00054620#function" } ] }, { "annotation": "Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2#function" }, { "database": "UniProtKB", "id": "ARBA00055817", "url": "https://www.uniprot.org/uniprotkb/ARBA00055817#function" } ] }, { "annotation": "Required for bundling actin filaments around the nucleus.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2#function" }, { "database": "UniProtKB", "id": "ARBA00057123", "url": "https://www.uniprot.org/uniprotkb/ARBA00057123#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DST", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2", "locus": { "chromosome": "23", "start_pos": 3768050, "end_pos": 3253421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021237", "url": "https://www.ensembl.org/id/ENSBTAG00000021237" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021237", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00176", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00176", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21239", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21239", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MPT5", "url": "https://www.orthodb.org/?gene=F1MPT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23169:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23169:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02187", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02187", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27015", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27015", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPT5", "url": "https://www.uniprot.org/uniprotkb/F1MPT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MPT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNVCGCVRAEKEEQCLDPAKTPLRLEKYSAGRRKYFRRDLTKKAADDTESGGPRLDDEGKRSARPLSGGQAAPWAWGLVQERGASPGLTLQAGVQPQMASGQRYPGCPSQHQETQIRVSIPEERVSEKDSTPYHAKRKDHFDDVNTRKRTFQRKTGGFSSQKAASLSSIHCGTERSLEKGGFSEDPSKNDSGIQEKQNTERSCLQEAHRFQFGKKRYHSLCDNMSFPSKDTKEISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLVQWIRHHVATMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRGSVICEDKLLLARNALQSDSKRLESGLQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDDIMALRNECSSVYSKGRVLTTEQTKLMISGISQSLNAGFAQTLNPSMNSGLTQGLTPSLTPSSVTSGLSSGLTSRLTPSVTPAYTPGFPSGLVPSFGSGGETSSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLENQYAKLLNTSRNQERHLDTLHNFVTRATNELIWLNEKEEEEVAYDWSERNTNIARKRDYHAELMRELDQKEETIKSVQEIAERLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHVKENSAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTVASLMGRAKTIVQLKPRNADCPLKTSLPIKAICDYRQIEITIFKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHHLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQIFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESAYNLYISEVRNLRLRLESCEDRLIRQIRTPLERDDLHESVFRISEQEKLKKELERLKDDLATITSKCEDFFSQAPASASTPALRSELSVVVQSMNHVYSMSSTYIEKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKREVFHELEDELQRAKTISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHLLDDWIQQVETTQRKIQENQPENSKALATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSTAVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLVIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKVKELQKWVSNISKTLRDGEKAGKSSFSKQKISSEEISIKKEQLSETLQGMQLFLAKHGDKMTDEERNELEKQVKTLQESYNLFFSESLKQLQQLQTLGDIKVEEKLDKVIAGTVDQSTGEVLSVFQSVLRGLLDYDTGIRLLETQLMISGLISPELRTCFNLKDAQSHGLIDEQVLSQLQELNEMKEIISAVSSTRVPVLDALAEGVISEPMAIRVLEILLSTGSLVIPATGEQLTLQKAFQQHLVSSALFSKILERQSLCKDLIDPSTSEKVSLIDIMQRSVLQEDLGMRLLPVRPQEGGRITLKCGRNVSILRAAHEGLIDRETMFRLLGAQLLSGGLINSKSGRRLTVEEAVAEGVMDRDTANSILTYQVETGGIIRCNPAKRLTVDEAVQCNLIPSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELASKILEGRQKIAALYIPETCQVIDLEVATQLGIIDNYTASILKSITLPDKMPNLGDLEACKNARRWLSFCKFQPSMVHDYRLDEDAFDGEEPVATQSSEQTKKLFLSYLMINSYMDANTGQRLLLYDGDLNEAVGMLLEGCGAEIDKDTPIEECFDVLRLPGVSLNNTASKEMGESPASPSSFDKCHQREPEHKVTPENTIDEEFQELEINVIRSEFWLSENLADVITTDLKVKKSPGVSVPSSRSHLTQLGLADVSLPRQDSENRVENGENQCQLETKEHADECSHSKNLQNLASDLITDPMIKSKTSRAYDLNETENEDNISRGSVLFDYSPRLSALLSHDKLRTEQGSFHDVHSAESNGKKCETSTLPFNDQTESSGQRIREKFQDQFLGIAAINISLKGEQAEEKSFNVGCSNPQVECQSDEFSSDTCDEDENALATSQQEPEDENRESTVEGSSGAPTPRAGGHDVVLAPTHTPSFEGTVGASAGDYETSLLDDRCSETDTDSDADFYDTPLSEDDDHDSLLLEGDDCDCLQPEDYDSLPEEDEWAAPPGEVFYDVSKEEEHSVGTQAGLAESLGVRGGAQSLQDFLIGAEKAELGSGEEIQLNSFESYEVSGPLMETVSERDSTDDLEGDESDSLTDYETEGGKESFTMAVESEDAGCWEGREKDCVAGQGFESAPDHLDSVQSKDSYEESVSGPNEQDDDDRGADAGDGAGGEGAEPVGQGAAAAVVVPGCVAAAPETENSHASQRNNKTILLTQKHHHNSKQKQQCVNVLQPESSSKSSLGPEINCFPEDTNEVVGKSIEDLLNHEMVLQDELLPIMKDTESENIFSPVGALPNTSVSSASELKGHLKNTGLELIQPGSADSVKGGNPYCENVTLRGNSSSDKIICPEPSLTGKPAEESHLSFTMSVADNDPPGSGRDLIKRTADKSNVQIEDEASLPKMCAGKGEVLIEGPLEDKYPKLLPSKSTRESLDIVNSLFPVPQTIHSEEHSQEESLKNTAVALKDEPQNLPTVVSRSPVQFENLEEIFDSSVSQVINDDMTSDVTLSEGFTKIETDSLTDGPEDELDLFTYLKHCAKDVKAKDVLKPGEDTPSCIPVTSPPIKEHLQLGVNNADEKAALAQEDSPPKEMGQQKDLPAEESRSGIPKLTPAGDESMPSGFPLGNAEGLGKHMDFVQSDLCADGVRNNSSKALSTDCSSLEIHSEKEGIEQQKGKEPAPSPGAQGSKVQVAELSQVLVEDITDTLKGNLKEGRVTPQELGKPSACADANILIQTFIKRVSSSQLVNETPGVPSNSNTSGCGISCAKNSESREDPLCAANLKSELLLDILKQSQYSQKVIGAFELMKELTQMECDLEEKGGASELLPLQLEDIFCKLLPDGYSEKGGQHTDLSKKSPTAPEVTDEEPHILEEFNSKEGNPCSLNLQSVKESGPENSPVCAPALSRDGRLKELCAASPGHLECISGSEDLASGDSLMERFSKELQQCLQHRSKMCEYLALLQDMKPPFGSQDSRDGSLEALRDQLKQLETFELGLAPIGVILRKDMTLAEEFVKSVPSDFPRGPLEDLSMSLQSLQTALSSLQAVSSERMSHITLAIDSEVSKLAVSHEEFLQKLQSFSCWISETSKSVKDVEIMTVRDAELIKQSLEFLKNVLKDLGHTKTQLETTAFDVQFFISEHAQDLSPTQSRQLLRLLNTTQKGFLDMQDSVTTQVEHLEAQLQLEQDLDHQKLVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFVIGDGTAELKKYQSKQEELQKDMQGSAQALAEIVKNTENFLKESGEKLSQEDKAVIEQKLNEAKIKCEQLTIKAEQSKKELDKVVTTAIREETEKVVAAKQLEESKTKIENLLDWLANVERDSGRAAMEPKQIIEQNGTHFQEGDGKLMMGEEDEFNGNLLDTDVDGRVGTTEENLNQQYQKMKAQHAELVAQQQAVLAATQAAQALLETQGHHLCPEEKEKLQRNVTELKTHFESALAASETAVRRTRSLQEELQKFDTDCGEFEQWLQQAEQDLQNLEAGADDLRGLTAKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCGGREGGGRADRDQVDTSAAHREVQGRLDRATERFRSLYTKCNVLGNNLKDLVDKYQHYEDASSGLLSGLQACEATASRHLSEPIAVDPKNLQRQLEEMKALQGQISSQQVAVEKLKKTAEVLLDSRASLLPAKSDIQKTLDDIVGRYDDLSASVSERNEKLQMTLTRSLSVQDGLDEMLLWMEGVERCLQEPCQLPLSSTALQDVISKSIMLEQDIAGRQSSINAMNEKVKRFTETTDPSTASSLQARMKDLAFRFSEASHKHKEKLAQVEKLKTKVERFENLSEKLHTFLEAKTQALTEADVPGKDVTELSQFMQESTSELLERKKDLEVLQNLLKEISSHGLPGDKALVFEKTNNLSKKFKEMEDTVKEKKEAVSSCQEQMGAFQVLVKSLKSWIKETTERVPVVQPSFGAEDLQKSLEETKKLQEKWSLKTPEIQKVSDSGNSLCNLISAVTTPAKAIAAVKSGGVILNGEGTATDTQEVLANKGLTSIKKDMTDISHGYEDLGLLLKDKIGELSTKLSRLQKAQEESSAMMQWLQTMSNTATKWHQAPTPVDTEAVKSQVEQNKLFDAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTVDRQQKLEESSNTLTQFQTVEAQLKQWLVEKELMVSVLGPLSVDPNMLNTQRQQVQILLQEFDTRKPQYEQLTTAGRGILQRPGEHPSLHGTVKEQLAAVTQKWDSLTGQLRDRCDRIDQAVGKSTQYQSLLRSLSEKLADLDDQLSSSVAGSAHPDAMSQQLETAQKLKQAVEQEGKRISAAQALGDDLAALVREEYLRAELSRQLEGVLKSFKDLEQKAETHVEHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSPLISAKVDVLESLVKDQKDFRKTLTAQSHLYEKTIAEGENLLLKTQGSEKVALQLQLNTIKTNWDGLQKQVKDREDRVKDTLERALKYKEHVDTLRPWIDRCQGSLEEIKCSLDPAETENALARLKALQKEMDQHFGLVEQLSGAAGSLLGVCEVDQEVVAEERECLLRKVDTVTEQVHRKKFSLENMAQKFKEFQEVSREAQRQLQGAKDQLAVHDSLGPQAHSSKSLTVLQTQQKALQTLKSQVDLAQGLARDLVAEASDSKGTSEILLQAETLAQEHDSLSQQVDDKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDGMAPVGRDAETLQKQKEAIRAFLEKLDALIANNANANKTCKMMLATEEASPDLVGIKRDLEALSKQCNKLWDRAQARKEQVEGTIVRLEEFYSKLQEFSTLLQKAEELEESQGPVGMETETINQQLDVFKVFQKEEIEPLQVKHQDVNWLGQGLIQSAAKGASTEALEHDLDDAGARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMGDTEELVANQKAPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAATAEPPDKVKILKQLSLLDSRWEALLSKAETRNRQLEGISVVAQQFHETLEPLNEWLSTTEKRLANCEPVGTQASKLEEQIEQHKALEDDILHHNKHLHQTVSIGQSLKVLSSREDKDMVQSKLDSSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLSEVHDKLRRLSVQDSSPEGLWTQQAELRVLQEDIQLRKQNVDQALLNGLELLKRTTGDEVLIIQDKLEAIKARYQDITKLSTDVAKTLEQALQLARRLQSTHEELCAWLDKVEVELLSYETQVLKGEAASQAHARQKELKKEAKSHKALLDSLNEVSTALLELVPWRAREGLERTVAEDNDRFRLVSDAVAQRVEAIDAALLRAQQFDQAADAELAWINETEKKLTSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDELVKSGHKIMSTCSEEEKQPMKKKLDTVLKNYDAICQVNSERYLQLERAQSLVSQFWETYEELWPWLTDTQKAIAQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPREGFSIQEKYVAADTLYSQIKEDVRKRAVALDEAISQSTQFHDKIDQILESLERVVERLRQPPSISAEVEKIREQVSENKNVAVDMEKLQPLYETLRQRGEEMIARSQGTDKDISAKAVQDKLDQMVFIWENIHVLVEEREAKLLDVMELAEKFWCDHLSLVVTTKDTQDFIRDLEDPGIDPSVVKQQQEAAEVIREEIDGLQEELDMVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRVDRLEEAMQTAVQYQDGLQALFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLDERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLGEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASSLQNKLEVLNQRWQNVLEKTEQRKQHLDAALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAREQLNAHLEICAAFDVKEETYKNLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKVKLEEALTLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDEARKRAKQFHDAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTSRTGRSLKEKTTLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKVFQKELGKRTSSVQALKRSARELIEGNQDDSSWVRVQVQELSTRWETVCALSISKQSRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKRLEEKRAALNKATSMGDAILAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLSDRDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRLPAPSFYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGATQGMAAFRPRGRRSRPSSRAASPSRSTSVSGQAGQAASPQVPASSTPKILHPLTRNYGKPWLTNSKVSTPCKPAECPDFPVSSPEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADPRRTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPPTHRPTPRAGSRPPGAKPSKIPTPQRKSPASKLDKSSKR", "length": 7665, "header": "tr|A0AAA9SCC2-1|A0AAA9SCC2_BOVIN Isoform 1 of Dystonin OS=Bos taurus OX=9913 GN=DST PE=4 SV=1 CANONICAL=A0AAA9SCC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#A0AAA9SCC2-1", "sequence": { "sequence": "MGNVCGCVRAEKEEQCLDPAKTPLRLEKYSAGRRKYFRRDLTKKAADDTESGGPRLDDEGKRSARPLSGGQAAPWAWGLVQERGASPGLTLQAGVQPQMASGQRYPGCPSQHQETQIRVSIPEERVSEKDSTPYHAKRKDHFDDVNTRKRTFQRKTGGFSSQKAASLSSIHCGTERSLEKGGFSEDPSKNDSGIQEKQNTERSCLQEAHRFQFGKKRYHSLCDNMSFPSKDTKEISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLVQWIRHHVATMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRGSVICEDKLLLARNALQSDSKRLESGLQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDDIMALRNECSSVYSKGRVLTTEQTKLMISGISQSLNAGFAQTLNPSMNSGLTQGLTPSLTPSSVTSGLSSGLTSRLTPSVTPAYTPGFPSGLVPSFGSGGETSSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLENQYAKLLNTSRNQERHLDTLHNFVTRATNELIWLNEKEEEEVAYDWSERNTNIARKRDYHAELMRELDQKEETIKSVQEIAERLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHVKENSAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTVASLMGRAKTIVQLKPRNADCPLKTSLPIKAICDYRQIEITIFKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHHLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQIFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESAYNLYISEVRNLRLRLESCEDRLIRQIRTPLERDDLHESVFRISEQEKLKKELERLKDDLATITSKCEDFFSQAPASASTPALRSELSVVVQSMNHVYSMSSTYIEKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKREVFHELEDELQRAKTISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHLLDDWIQQVETTQRKIQENQPENSKALATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSTAVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLVIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKVKELQKWVSNISKTLRDGEKAGKSSFSKQKISSEEISIKKEQLSETLQGMQLFLAKHGDKMTDEERNELEKQVKTLQESYNLFFSESLKQLQQLQTLGDIKVEEKLDKVIAGTVDQSTGEVLSVFQSVLRGLLDYDTGIRLLETQLMISGLISPELRTCFNLKDAQSHGLIDEQVLSQLQELNEMKEIISAVSSTRVPVLDALAEGVISEPMAIRVLEILLSTGSLVIPATGEQLTLQKAFQQHLVSSALFSKILERQSLCKDLIDPSTSEKVSLIDIMQRSVLQEDLGMRLLPVRPQEGGRITLKCGRNVSILRAAHEGLIDRETMFRLLGAQLLSGGLINSKSGRRLTVEEAVAEGVMDRDTANSILTYQVETGGIIRCNPAKRLTVDEAVQCNLIPSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELASKILEGRQKIAALYIPETCQVIDLEVATQLGIIDNYTASILKSITLPDKMPNLGDLEACKNARRWLSFCKFQPSMVHDYRLDEDAFDGEEPVATQSSEQTKKLFLSYLMINSYMDANTGQRLLLYDGDLNEAVGMLLEGCGAEIDKDTPIEECFDVLRLPGVSLNNTASKEMGESPASPSSFDKCHQREPEHKVTPENTIDEEFQELEINVIRSEFWLSENLADVITTDLKVKKSPGVSVPSSRSHLTQLGLADVSLPRQDSENRVENGENQCQLETKEHADECSHSKNLQNLASDLITDPMIKSKTSRAYDLNETENEDNISRGSVLFDYSPRLSALLSHDKLRTEQGSFHDVHSAESNGKKCETSTLPFNDQTESSGQRIREKFQDQFLGIAAINISLKGEQAEEKSFNVGCSNPQVECQSDEFSSDTCDEDENALATSQQEPEDENRESTVEGSSGAPTPRAGGHDVVLAPTHTPSFEGTVGASAGDYETSLLDDRCSETDTDSDADFYDTPLSEDDDHDSLLLEGDDCDCLQPEDYDSLPEEDEWAAPPGEVFYDVSKEEEHSVGTQAGLAESLGVRGGAQSLQDFLIGAEKAELGSGEEIQLNSFESYEVSGPLMETVSERDSTDDLEGDESDSLTDYETEGGKESFTMAVESEDAGCWEGREKDCVAGQGFESAPDHLDSVQSKDSYEESVSGPNEQDDDDRGADAGDGAGGEGAEPVGQGAAAAVVVPGCVAAAPETENSHASQRNNKTILLTQKHHHNSKQKQQCVNVLQPESSSKSSLGPEINCFPEDTNEVVGKSIEDLLNHEMVLQDELLPIMKDTESENIFSPVGALPNTSVSSASELKGHLKNTGLELIQPGSADSVKGGNPYCENVTLRGNSSSDKIICPEPSLTGKPAEESHLSFTMSVADNDPPGSGRDLIKRTADKSNVQIEDEASLPKMCAGKGEVLIEGPLEDKYPKLLPSKSTRESLDIVNSLFPVPQTIHSEEHSQEESLKNTAVALKDEPQNLPTVVSRSPVQFENLEEIFDSSVSQVINDDMTSDVTLSEGFTKIETDSLTDGPEDELDLFTYLKHCAKDVKAKDVLKPGEDTPSCIPVTSPPIKEHLQLGVNNADEKAALAQEDSPPKEMGQQKDLPAEESRSGIPKLTPAGDESMPSGFPLGNAEGLGKHMDFVQSDLCADGVRNNSSKALSTDCSSLEIHSEKEGIEQQKGKEPAPSPGAQGSKVQVAELSQVLVEDITDTLKGNLKEGRVTPQELGKPSACADANILIQTFIKRVSSSQLVNETPGVPSNSNTSGCGISCAKNSESREDPLCAANLKSELLLDILKQSQYSQKVIGAFELMKELTQMECDLEEKGGASELLPLQLEDIFCKLLPDGYSEKGGQHTDLSKKSPTAPEVTDEEPHILEEFNSKEGNPCSLNLQSVKESGPENSPVCAPALSRDGRLKELCAASPGHLECISGSEDLASGDSLMERFSKELQQCLQHRSKMCEYLALLQDMKPPFGSQDSRDGSLEALRDQLKQLETFELGLAPIGVILRKDMTLAEEFVKSVPSDFPRGPLEDLSMSLQSLQTALSSLQAVSSERMSHITLAIDSEVSKLAVSHEEFLQKLQSFSCWISETSKSVKDVEIMTVRDAELIKQSLEFLKNVLKDLGHTKTQLETTAFDVQFFISEHAQDLSPTQSRQLLRLLNTTQKGFLDMQDSVTTQVEHLEAQLQLEQDLDHQKLVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFVIGDGTAELKKYQSKQEELQKDMQGSAQALAEIVKNTENFLKESGEKLSQEDKAVIEQKLNEAKIKCEQLTIKAEQSKKELDKVVTTAIREETEKVVAAKQLEESKTKIENLLDWLANVERDSGRAAMEPKQIIEQNGTHFQEGDGKLMMGEEDEFNGNLLDTDVDGRVGTTEENLNQQYQKMKAQHAELVAQQQAVLAATQAAQALLETQGHHLCPEEKEKLQRNVTELKTHFESALAASETAVRRTRSLQEELQKFDTDCGEFEQWLQQAEQDLQNLEAGADDLRGLTAKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCGGREGGGRADRDQVDTSAAHREVQGRLDRATERFRSLYTKCNVLGNNLKDLVDKYQHYEDASSGLLSGLQACEATASRHLSEPIAVDPKNLQRQLEEMKALQGQISSQQVAVEKLKKTAEVLLDSRASLLPAKSDIQKTLDDIVGRYDDLSASVSERNEKLQMTLTRSLSVQDGLDEMLLWMEGVERCLQEPCQLPLSSTALQDVISKSIMLEQDIAGRQSSINAMNEKVKRFTETTDPSTASSLQARMKDLAFRFSEASHKHKEKLAQVEKLKTKVERFENLSEKLHTFLEAKTQALTEADVPGKDVTELSQFMQESTSELLERKKDLEVLQNLLKEISSHGLPGDKALVFEKTNNLSKKFKEMEDTVKEKKEAVSSCQEQMGAFQVLVKSLKSWIKETTERVPVVQPSFGAEDLQKSLEETKKLQEKWSLKTPEIQKVSDSGNSLCNLISAVTTPAKAIAAVKSGGVILNGEGTATDTQEVLANKGLTSIKKDMTDISHGYEDLGLLLKDKIGELSTKLSRLQKAQEESSAMMQWLQTMSNTATKWHQAPTPVDTEAVKSQVEQNKLFDAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTVDRQQKLEESSNTLTQFQTVEAQLKQWLVEKELMVSVLGPLSVDPNMLNTQRQQVQILLQEFDTRKPQYEQLTTAGRGILQRPGEHPSLHGTVKEQLAAVTQKWDSLTGQLRDRCDRIDQAVGKSTQYQSLLRSLSEKLADLDDQLSSSVAGSAHPDAMSQQLETAQKLKQAVEQEGKRISAAQALGDDLAALVREEYLRAELSRQLEGVLKSFKDLEQKAETHVEHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSPLISAKVDVLESLVKDQKDFRKTLTAQSHLYEKTIAEGENLLLKTQGSEKVALQLQLNTIKTNWDGLQKQVKDREDRVKDTLERALKYKEHVDTLRPWIDRCQGSLEEIKCSLDPAETENALARLKALQKEMDQHFGLVEQLSGAAGSLLGVCEVDQEVVAEERECLLRKVDTVTEQVHRKKFSLENMAQKFKEFQEVSREAQRQLQGAKDQLAVHDSLGPQAHSSKSLTVLQTQQKALQTLKSQVDLAQGLARDLVAEASDSKGTSEILLQAETLAQEHDSLSQQVDDKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDGMAPVGRDAETLQKQKEAIRAFLEKLDALIANNANANKTCKMMLATEEASPDLVGIKRDLEALSKQCNKLWDRAQARKEQVEGTIVRLEEFYSKLQEFSTLLQKAEELEESQGPVGMETETINQQLDVFKVFQKEEIEPLQVKHQDVNWLGQGLIQSAAKGASTEALEHDLDDAGARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMGDTEELVANQKAPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAATAEPPDKVKILKQLSLLDSRWEALLSKAETRNRQLEGISVVAQQFHETLEPLNEWLSTTEKRLANCEPVGTQASKLEEQIEQHKALEDDILHHNKHLHQTVSIGQSLKVLSSREDKDMVQSKLDSSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLSEVHDKLRRLSVQDSSPEGLWTQQAELRVLQEDIQLRKQNVDQALLNGLELLKRTTGDEVLIIQDKLEAIKARYQDITKLSTDVAKTLEQALQLARRLQSTHEELCAWLDKVEVELLSYETQVLKGEAASQAHARQKELKKEAKSHKALLDSLNEVSTALLELVPWRAREGLERTVAEDNDRFRLVSDAVAQRVEAIDAALLRAQQFDQAADAELAWINETEKKLTSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDELVKSGHKIMSTCSEEEKQPMKKKLDTVLKNYDAICQVNSERYLQLERAQSLVSQFWETYEELWPWLTDTQKAIAQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPREGFSIQEKYVAADTLYSQIKEDVRKRAVALDEAISQSTQFHDKIDQILESLERVVERLRQPPSISAEVEKIREQVSENKNVAVDMEKLQPLYETLRQRGEEMIARSQGTDKDISAKAVQDKLDQMVFIWENIHVLVEEREAKLLDVMELAEKFWCDHLSLVVTTKDTQDFIRDLEDPGIDPSVVKQQQEAAEVIREEIDGLQEELDMVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRVDRLEEAMQTAVQYQDGLQALFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLDERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLGEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASSLQNKLEVLNQRWQNVLEKTEQRKQHLDAALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAREQLNAHLEICAAFDVKEETYKNLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKVKLEEALTLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDEARKRAKQFHDAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTSRTGRSLKEKTTLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKVFQKELGKRTSSVQALKRSARELIEGNQDDSSWVRVQVQELSTRWETVCALSISKQSRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKRLEEKRAALNKATSMGDAILAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLSDRDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRLPAPSFYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGATQGMAAFRPRGRRSRPSSRAASPSRSTSVSGQAGQAASPQVPASSTPKILHPLTRNYGKPWLTNSKVSTPCKPAECPDFPVSSPEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADPRRTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPPTHRPTPRAGSRPPGAKPSKIPTPQRKSPASKLDKSSKR", "length": 7665, "header": "tr|A0AAA9SCC2-1|A0AAA9SCC2_BOVIN Isoform 1 of Dystonin OS=Bos taurus OX=9913 GN=DST PE=4 SV=1 CANONICAL=A0AAA9SCC2-1" }, "locus": { "chromosome": "23", "start_pos": 3767046, "end_pos": 3522285, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093409.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093409.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083774.1" } ] } }, { "isoform_ac": "A0AAA9SX66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#A0AAA9SX66-1", "sequence": { "sequence": "MHSSSYSYRSSDSVFSNTTSTRTSLDSNENFLSVHCGPTLINSCISFGNESFDGHRLEMLQQIANRVQRGSVICEDKLLLARNALQSDSKRLESGLQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDDIMALRNECSSVYSKGRVLTTEQTKLMISGISQSLNAGFAQTLNPSMNSGLTQGLTPSLTPSSVTSGLSSGLTSRLTPSVTPAYTPGFPSGLVPSFGSGGETSSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLENQYAKLLNTSRNQERHLDTLHNFVTRATNELIWLNEKEEEEVAYDWSERNTNIARKRDYHAELMRELDQKEETIKSVQEIAERLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHVKENSAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTVASLMGRAKTIVQLKPRNADCPLKTSLPIKAICDYRQIEITIFKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHHLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQIFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESAYNLYISEVRNLRLRLESCEDRLIRQIRTPLERDDLHESVFRISEQEKLKKELERLKDDLATITSKCEDFFSQAPASASTPALRSELSVVVQSMNHVYSMSSTYIEKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKREVFHELEDELQRAKTISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHLLDDWIQQVETTQRKIQENQPENSKALATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSTAVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLVIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKVKELQKWVSNISKTLRDGEKAGKSSFSKQKISSEEISIKKEQLSETLQGMQLFLAKHGDKMTDEERNELEKQVKTLQESYNLFFSESLKQLQQLQTLGDIKVEEKLDKVIAGTVDQSTGEVLSVFQSVLRGLLDYDTGIRLLETQLMISGLISPELRTCFNLKDAQSHGLIDEQVLSQLQELNEMKEIISAVSSTRVPVLDALAEGVISEPMAIRVLEILLSTGSLVIPATGEQLTLQKAFQQHLVSSALFSKILERQSLCKDLIDPSTSEKVSLIDIMQRSVLQEDLGMRLLPVRPQEGGRITLKCGRNVSILRAAHEGLIDRETMFRLLGAQLLSGGLINSKSGRRLTVEEAVAEGVMDRDTANSILTYQVETGGIIRCNPAKRLTVDEAVQCNLIPSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELASKILEGRQKIAALYIPETCQVIDLEVATQLGIIDNYTASILKSITLPDKMPNLGDLEACKNARRWLSFCKFQPSMVHDYRLDEDAFDGEEPVATQSSEQTKKLFLSYLMINSYMDANTGQRLLLYDGDLNEAVGMLLEGCGAEIDKDTPIEECFDVLRLPGVSLNNTASKEMGESPASPSSFDKCHQREPEHKVTPENTIDEEFQELEINVIRSEFWLSENLADVITTDLKVKKSPGVSVPSSRSHLTQLGLADVSLPRQDSENRVENGENQCQLETKEHADECSHSKNLQNLASDLITDPMIKSKTSRAYDLNETENEDNISRGSVLFDYSPRLSALLSHDKLRTEQGSFHDVHSAESNGKKCETSTLPFNDQTESSGQRIREKFQDQFLGIAAINISLKGEQAEEKSFNVGCSNPQVECQSDEFSSDTCDEDENALATSQQEPEDENRESTVEGSSGAPTPRAGGHDVVLAPTHTPSFEGTVGASAGDYETSLLDDRCSETDTDSDADFYDTPLSEDDDHDSLLLEGDDCDCLQPEDYDSLPEEDEWAAPPGEVFYDVSKEEEHSVGTQAGLAESLGVRGGAQSLQDFLIGAEKAELGSGEEIQLNSFESYEVSGPLMETVSERDSTDDLEGDESDSLTDYETEGGKESFTMAVESEDAGCWEGREKDCVAGQGFESAPDHLDSVQSKDSYEESVSGPNEQDDDDRGADAGDGAGGEGAEPVGQGAAAAVVVPGCVAAAPETENSHASQRNNKTILLTQKHHHNSKQKQQCVNVLQPESSSKSSLGPEINCFPEDTNEVVGKSIEDLLNHEMVLQDELLPIMKDTESENIFSPVGALPNTSVSSASELKGHLKNTGLELIQPGSADSVKGGNPYCENVTLRGNSSSDKIICPEPSLTGKPAEESHLSFTMSVADNDPPGSGRDLIKRTADKSNVQIEDEASLPKMCAGKGEVLIEGPLEDKYPKLLPSKSTRESLDIVNSLFPVPQTIHSEEHSQEESLKNTAVALKDEPQNLPTVVSRSPVQFENLEEIFDSSVSQVINDDMTSDVTLSEGFTKIETDSLTDGPEDELDLFTYLKHCAKDVKAKDVLKPGEDTPSCIPVTSPPIKEHLQLGVNNADEKAALAQEDSPPKEMGQQKDLPAEESRSGIPKLTPAGDESMPSGFPLGNAEGLGKHMDFVQSDLCADGVRNNSSKALSTDCSSLEIHSEKEGIEQQKGKEPAPSPGAQGSKVQVAELSQVLVEDITDTLKGNLKEGRVTPQELGKPSACADANILIQTFIKRVSSSQLVNETPGVPSNSNTSGCGISCAKNSESREDPLCAANLKSELLLDILKQSQYSQKVIGAFELMKELTQMECDLEEKGGASELLPLQLEDIFCKLLPDGYSEKGGQHTDLSKKSPTAPEVTDEEPHILEEFNSKEGNPCSLNLQSVKESGPENSPVCAPALSRDGRLKELCAASPGHLECISGSEDLASGDSLMERFSKELQQCLQHRSKMCEYLALLQDMKPPFGSQDSRDGSLEALRDQLKQLETFELGLAPIGVILRKDMTLAEEFVKSVPSDFPRGPLEDLSMSLQSLQTALSSLQAVSSERMSHITLAIDSEVSKLAVSHEEFLQKLQSFSCWISETSKSVKDVEIMTVRDAELIKQSLEFLKNVLKDLGHTKTQLETTAFDVQFFISEHAQDLSPTQSRQLLRLLNTTQKGFLDMQDSVTTQVEHLEAQLQLEQDLDHQKLVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFVIGDGTAELKKYQSKQEELQKDMQGSAQALAEIVKNTENFLKESGEKLSQEDKAVIEQKLNEAKIKCEQLTIKAEQSKKELDKVVTTAIREETEKVVAAKQLEESKTKIENLLDWLANVERDSGRAAMEPKQIIEQNGTHFQEGDGKLMMGEEDEFNGNLLDTDVDGRVGTTEENLNQQYQKMKAQHAELVAQQQAVLAATQAAQALLETQGHHLCPEEKEKLQRNVTELKTHFESALAASETAVRRTRSLQEELQKFDTDCGEFEQWLQQAEQDLQNLEAGADDLRGLTAKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCGGREGGGRADRDQVDTSAAHREVQGRLDRATERFRSLYTKCNVLGNNLKDLVDKYQHYEDASSGLLSGLQACEATASRHLSEPIAVDPKNLQRQLEEMKALQGQISSQQVAVEKLKKTAEVLLDSRASLLPAKSDIQKTLDDIVGRYDDLSASVSERNEKLQMTLTRSLSVQDGLDEMLLWMEGVERCLQEPCQLPLSSTALQDVISKSIMLEQDIAGRQSSINAMNEKVKRFTETTDPSTASSLQARMKDLAFRFSEASHKHKEKLAQVEKLKTKVERFENLSEKLHTFLEAKTQALTEADVPGKDVTELSQFMQESTSELLERKKDLEVLQNLLKEISSHGLPGDKALVFEKTNNLSKKFKEMEDTVKEKKEAVSSCQEQMGAFQVLVKSLKSWIKETTERVPVVQPSFGAEDLQKSLEETKKLQEKWSLKTPEIQKVSDSGNSLCNLISAVTTPAKAIAAVKSGGVILNGEGTATDTQEVLANKGLTSIKKDMTDISHGYEDLGLLLKDKIGELSTKLSRLQKAQEESSAMMQWLQTMSNTATKWHQAPTPVDTEAVKSQVEQNKLFDAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTVDRQQKLEESSNTLTQFQTVEAQLKQWLVEKELMVSVLGPLSVDPNMLNTQRQQVQILLQEFDTRKPQYEQLTTAGRGILQRPGEHPSLHGTVKEQLAAVTQKWDSLTGQLRDRCDRIDQAVGKSTQYQSLLRSLSEKLADLDDQLSSSVAGSAHPDAMSQQLETAQKLKQAVEQEGKRISAAQALGDDLAALVREEYLRAELSRQLEGVLKSFKDLEQKAETHVEHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSPLISAKVDVLESLVKDQKDFRKTLTAQSHLYEKTIAEGENLLLKTQGSEKVALQLQLNTIKTNWDGLQKQVKDREDRVKDTLERALKYKEHVDTLRPWIDRCQGSLEEIKCSLDPAETENALARLKALQKEMDQHFGLVEQLSGAAGSLLGVCEVDQEVVAEERECLLRKVDTVTEQVHRKKFSLENMAQKFKEFQEVSREAQRQLQGAKDQLAVHDSLGPQAHSSKSLTVLQTQQKALQTLKSQVDLAQGLARDLVAEASDSKGTSEILLQAETLAQEHDSLSQQVDDKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDGMAPVGRDAETLQKQKEAIRAFLEKLDALIANNANANKTCKMMLATEEASPDLVGIKRDLEALSKQCNKLWDRAQARKEQVEGTIVRLEEFYSKLQEFSTLLQKAEELEESQGPVGMETETINQQLDVFKVFQKEEIEPLQVKHQDVNWLGQGLIQSAAKGASTEALEHDLDDAGARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMGDTEELVANQKAPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAATAEPPDKVKILKQLSLLDSRWEALLSKAETRNRQLEGISVVAQQFHETLEPLNEWLSTTEKRLANCEPVGTQASKLEEQIEQHKALEDDILHHNKHLHQTVSIGQSLKVLSSREDKDMVQSKLDSSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLSEVHDKLRRLSVQDSSPEGLWTQQAELRVLQEDIQLRKQNVDQALLNGLELLKRTTGDEVLIIQDKLEAIKARYQDITKLSTDVAKTLEQALQLARRLQSTHEELCAWLDKVEVELLSYETQVLKGEAASQAHARQKELKKEAKSHKALLDSLNEVSTALLELVPWRAREGLERTVAEDNDRFRLVSDAVAQRVEAIDAALLRAQQFDQAADAELAWINETEKKLTSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDELVKSGHKIMSTCSEEEKQPMKKKLDTVLKNYDAICQVNSERYLQLERAQSLVSQFWETYEELWPWLTDTQKAIAQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPREGFSIQEKYVAADTLYSQIKEDVRKRAVALDEAISQSTQFHDKIDQILESLERVVERLRQPPSISAEVEKIREQVSENKNVAVDMEKLQPLYETLRQRGEEMIARSQGTDKDISAKAVQDKLDQMVFIWENIHVLVEEREAKLLDVMELAEKFWCDHLSLVVTTKDTQDFIRDLEDPGIDPSVVKQQQEAAEVIREEIDGLQEELDMVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRVDRLEEAMQTAVQYQDGLQALFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLDERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLGEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASSLQNKLEVLNQRWQNVLEKTEQRKQHLDAALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAREQLNAHLEICAAFDVKEETYKNLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKVKLEEALTLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDEARKRAKQFHDAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTSRTGRSLKEKTTLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKVFQKELGKRTSSVQALKRSARELIEGNQDDSSWVRVQVQELSTRWETVCALSISKQSRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKRLEEKRAALNKATSMGDAILAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLSDRDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRLPAPSFYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGATQGMAAFRPRGRRSRPSSRAASPSRSTSVSGQAGQAASPQVPASSTPKILHPLTRNYGKPWLTNSKVSTPCKPAECPDFPVSSPEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADPRRTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPPTHRPTPRAGSRPPGAKPSKIPTPQRKSPASKLDKSSKR", "length": 7267, "header": "tr|A0AAA9SX66-1|A0AAA9SX66_BOVIN Computationally mapped isoform of Dystonin OS=Bos taurus OX=9913 GN=DST PE=4 SV=2 CANONICAL=A0AAA9SCC2-1" }, "locus": { "chromosome": "23", "start_pos": 3767046, "end_pos": 3575897, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101918.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101918.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091047.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091047.2" } ] } }, { "isoform_ac": "F1MPT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2/entry#F1MPT5-1", "sequence": { "sequence": "MGKPLSRPDCLRQNPPCVGKGEEEEDLNIEDCYVPQRSIYDTVRLNEQIDSGSKGSLSSRHFTDRTLPYSHRTLDVSSLCSNGPLASSSAFELRGREAHRLDEKMIFDALKLNSDVIRSTGLPKAKSHAEKKEHRRSWRMFVPANFVDYANKSESSFVEPADLSDAVAKAGKCRGATSSLPSEEDDSGLCGPPAEREEKQRLFPGDPSQIRSLSSVEDAHTAEQYRPFFSVNSISEQKMPLLSCRSTHLDDNFKMILHDASPPEETKPVHGQREIRGENSCLQDDVRESALKGGSFILPREGESKCISNPREEGRTYGSGEFQTTAQRREFVGDSPEELAVSCTDLGGNVIDWGGTGLVENLTLLTQYDSEESNVASQEDVEAPLSVQEMEAVCEPCSSQFRAVRKQAAPRKTGAHAGTLDPVCNGFHSAQVFQKEEIEPLQVKHQDVNWLGQGLIQSAAKGASTEALEHDLDDAGARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMGDTEELVANQKAPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAATAEPPDKVKILKQLSLLDSRWEALLSKAETRNRQLEGISVVAQQFHETLEPLNEWLSTTEKRLANCEPVGTQASKLEEQIEQHKALEDDILHHNKHLHQTVSIGQSLKVLSSREDKDMVQSKLDSSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLSEVHDKLRRLSVQDSSPEGLWTQQAELRVLQEDIQLRKQNVDQALLNGLELLKRTTGDEVLIIQDKLEAIKARYQDITKLSTDVAKTLEQALQLARRLQSTHEELCAWLDKVEVELLSYETQVLKGEAASQAHARQKELKKEAKSHKALLDSLNEVSTALLELVPWRAREGLERTVAEDNDRFRLVSDAVAQRVEAIDAALLRAQQFDQAADAELAWINETEKKLTSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDELVKSGHKIMSTCSEEEKQPMKKKLDTVLKNYDAICQVNSERYLQLERAQSLVSQFWETYEELWPWLTDTQKAIAQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPREGFSIQEKYVAADTLYSQIKEDVRKRAVALDEAISQSTQFHDKIDQILESLERVVERLRQPPSISAEVEKIREQVSENKNVAVDMEKLQPLYETLRQRGEEMIARSQGTDKDISAKAVQDKLDQMVFIWENIHVLVEEREAKLLDVMELAEKFWCDHLSLVVTTKDTQDFIRDLEDPGIDPSVVKQQQEAAEVIREEIDGLQEELDMVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRVDRLEEAMQTAVQYQDGLQALFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLDERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLGEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASSLQNKLEVLNQRWQNVLEKTEQRKQHLDAALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAREQLNAHLEICAAFDVKEETYKNLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKVKLEEALTLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDEARKRAKQFHDAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTSRTGRSLKEKTTLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKVFQKELGKRTSSVQALKRSARELIEGNQDDSSWVRVQVQELSTRWETVCALSISKQSRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKRLEEKRAALNKATSMGDAILAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLSDRDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRLPAPSFYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGATQGMAAFRPRGRRSRPSSRAASPSRSTSVSGQAGQAASPQVPASSTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADPRRTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPPTHRPTPRAGSRPPGAKPSKIPTPQRKSPASKLDKSSKR", "length": 2676, "header": "tr|F1MPT5-1|F1MPT5_BOVIN Computationally mapped isoform of Dystonin OS=Bos taurus OX=9913 GN=DST PE=4 SV=5 CANONICAL=A0AAA9SCC2-1" }, "locus": { "chromosome": "23", "start_pos": 3767046, "end_pos": 3678398, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061451.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061451.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053548.5", "url": "https://www.ensembl.org/id/ENSBTAP00000053548.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1239, "start_aa": "Thr", "end_pos": 1239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1239", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2444, "start_aa": "Thr", "end_pos": 2444, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2444", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 648, "start_aa": "Thr", "end_pos": 648, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr648", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "hemidesmosome", "id": "GO:0030056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030056", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "H zone", "id": "GO:0031673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031673", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" }, { "name": "intermediate filament cytoskeleton organization", "id": "GO:0045104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1011, "end_pos": 1013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1551, "end_pos": 1553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1851, "end_pos": 1853, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2017, "end_pos": 2019, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2147, "end_pos": 2149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2296, "end_pos": 2298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2303, "end_pos": 2305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2379, "end_pos": 2381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2736, "end_pos": 2738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2823, "end_pos": 2825, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2861, "end_pos": 2863, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2867, "end_pos": 2869, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3172, "end_pos": 3174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3173, "end_pos": 3175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3271, "end_pos": 3273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3281, "end_pos": 3283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3678, "end_pos": 3680, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3883, "end_pos": 3885, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3972, "end_pos": 3974, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4355, "end_pos": 4357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4430, "end_pos": 4432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4952, "end_pos": 4954, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5314, "end_pos": 5316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5927, "end_pos": 5929, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6080, "end_pos": 6082, "annotation": "n_glycosylation_sequon" }, { "start_pos": 693, "end_pos": 695, "annotation": "n_glycosylation_sequon" }, { "start_pos": 785, "end_pos": 787, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 247, "end_pos": 351, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 7279, "end_pos": 7314, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" }, { "id": "PS51460", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51460" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAR", "eco_id": "ECO_0000259", "start_pos": 7355, "end_pos": 7433, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCC2" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 983, "end_pos": 1040, "start_aa": "Lys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 648, 1239, 2444 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1011, "end_pos": 1013 }, { "start_pos": 1551, "end_pos": 1553 }, { "start_pos": 1851, "end_pos": 1853 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 2017, "end_pos": 2019 }, { "start_pos": 2147, "end_pos": 2149 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 2296, "end_pos": 2298 }, { "start_pos": 2303, "end_pos": 2305 }, { "start_pos": 2379, "end_pos": 2381 }, { "start_pos": 271, "end_pos": 273 }, { "start_pos": 2736, "end_pos": 2738 }, { "start_pos": 2823, "end_pos": 2825 }, { "start_pos": 2861, "end_pos": 2863 }, { "start_pos": 2867, "end_pos": 2869 }, { "start_pos": 3172, "end_pos": 3174 }, { "start_pos": 3173, "end_pos": 3175 }, { "start_pos": 3271, "end_pos": 3273 }, { "start_pos": 3281, "end_pos": 3283 }, { "start_pos": 3678, "end_pos": 3680 }, { "start_pos": 3883, "end_pos": 3885 }, { "start_pos": 3972, "end_pos": 3974 }, { "start_pos": 4355, "end_pos": 4357 }, { "start_pos": 4430, "end_pos": 4432 }, { "start_pos": 4952, "end_pos": 4954 }, { "start_pos": 5314, "end_pos": 5316 }, { "start_pos": 5927, "end_pos": 5929 }, { "start_pos": 6080, "end_pos": 6082 }, { "start_pos": 693, "end_pos": 695 }, { "start_pos": 785, "end_pos": 787 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCD8-1", "uniprot_ac": "A0AAA9SCD8", "uniprot_id": "A0AAA9SCD8_BOVIN", "mass": { "chemical_mass": 11512.0, "monoisotopic_mass": 11512.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SCD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SCD8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQKVTQDQPDISSQVGQSVTLNCRYETSSGVYYLFWYKQLPSGQMTYLIQQYSEHGNARNDRYSVNFQKADKSISLIISSLQLEDSAKYFCDKSWTNCDT", "length": 100, "header": "tr|A0AAA9SCD8-1|A0AAA9SCD8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SCD8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8/entry#A0AAA9SCD8-1", "sequence": { "sequence": "AQKVTQDQPDISSQVGQSVTLNCRYETSSGVYYLFWYKQLPSGQMTYLIQQYSEHGNARNDRYSVNFQKADKSISLIISSLQLEDSAKYFCDKSWTNCDT", "length": 100, "header": "tr|A0AAA9SCD8-1|A0AAA9SCD8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SCD8-1" }, "locus": { "chromosome": "NKLS02001214.1", "start_pos": 78089, "end_pos": 77145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126509.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126509.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083789.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083789.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCD8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 100, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCH0-1", "uniprot_ac": "A0AAA9SCH0", "uniprot_id": "A0AAA9SCH0_BOVIN", "mass": { "chemical_mass": 10449.0, "monoisotopic_mass": 10449.0 }, "refseq": { "ac": "XP_015329697", "name": "WAP four-disulfide core domain protein 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329697" }, "gene_names": [ { "name": "WFDC13", "type": "recommended", "evidence": [ { "id": "A0AAA9SCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0" } ] }, { "name": "WFDC13", "type": "synonym", "evidence": [ { "id": "XP_015329697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329697" } ] } ], "protein_names": [ { "name": "WAP four-disulfide core domain 13", "type": "synonym", "evidence": [ { "id": "A0AAA9SCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0/entry#names_and_taxonomy" } ] }, { "name": "WAP four-disulfide core domain protein 13", "type": "synonym", "evidence": [ { "id": "XP_015329697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329697" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WFDC13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0", "locus": { "chromosome": "13", "start_pos": 74483293, "end_pos": 74478978, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060937", "url": "https://www.ensembl.org/id/ENSBTAG00000060937" } ] } } ], "crossref": [ { "id": "A0AAA9SCH0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "101907910", "url": "https://www.ncbi.nlm.nih.gov/gene/101907910", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:101907910", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907910", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015329697", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329697", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPALFLQLLLLTHVASQLVSGSPKQHFRRYILEPPPCRSDPENCTDFCTLQEDCQPGFQCCSAFCGIVCTLNKDVNRKRPKPKTLRNNGVGK", "length": 93, "header": "tr|A0AAA9SCH0-1|A0AAA9SCH0_BOVIN Isoform 1 of WAP four-disulfide core domain 13 OS=Bos taurus OX=9913 GN=WFDC13 PE=4 SV=1 CANONICAL=A0AAA9SCH0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCH0/entry#A0AAA9SCH0-1", "sequence": { "sequence": "MKPALFLQLLLLTHVASQLVSGSPKQHFRRYILEPPPCRSDPENCTDFCTLQEDCQPGFQCCSAFCGIVCTLNKDVNRKRPKPKTLRNNGVGK", "length": 93, "header": "tr|A0AAA9SCH0-1|A0AAA9SCH0_BOVIN Isoform 1 of WAP four-disulfide core domain 13 OS=Bos taurus OX=9913 GN=WFDC13 PE=4 SV=1 CANONICAL=A0AAA9SCH0-1" }, "locus": { "chromosome": "13", "start_pos": 74483290, "end_pos": 74478978, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091841.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091841.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079941.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101907910", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907910", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCI3-1", "uniprot_ac": "A0AAA9SCI3", "uniprot_id": "A0AAA9SCI3_BOVIN", "mass": { "chemical_mass": 72963.0, "monoisotopic_mass": 72963.0 }, "refseq": { "ac": "NP_001421714", "name": "leucine-rich repeat and IQ domain-containing protein 3 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421714" }, "gene_names": [ { "name": "LRRIQ3", "type": "recommended", "evidence": [ { "id": "A0AAA9SCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3" } ] }, { "name": "LRRC44", "type": "synonym", "evidence": [ { "id": "NP_001421714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421714" } ] }, { "name": "LRRIQ3", "type": "synonym", "evidence": [ { "id": "NP_001421714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421714" } ] } ], "protein_names": [ { "name": "Leucine rich repeats and IQ motif containing 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SCI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3/entry#names_and_taxonomy" } ] }, { "name": "leucine rich repeat containing 44", "type": "synonym", "evidence": [ { "id": "NP_001421714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421714" } ] }, { "name": "leucine-rich repeat and IQ domain-containing protein 3 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421714" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRIQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3", "locus": { "chromosome": "3", "start_pos": 70817719, "end_pos": 70627499, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019401", "url": "https://www.ensembl.org/id/ENSBTAG00000019401" } ] } } ], "crossref": [ { "id": "A0AAA9SCI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019401", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019401", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523789", "url": "https://www.ncbi.nlm.nih.gov/gene/523789", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523789", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523789", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MPB9", "url": "https://www.orthodb.org/?gene=F1MPB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46723:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46723:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001421714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421714", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPB9", "url": "https://www.uniprot.org/uniprotkb/F1MPB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPB9-1", "url": "https://www.uniprot.org/uniprotkb/F1MPB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFHGTIIEELTNHREWSHYNENIIEDQKDFVFVKFSGLHLKSMENLQSCISLRVCIFSNNFITDIRPLQSCMKLIKLDLHGNQIKSLPDTKFWSGLKNLKLLYLHDNGFAKLKNLCMLSACPSLIALTMFDCPVSLKKGYRHVLVNSIWTLKALDHHVISDEEIIQNWHLPERFKTYNHRLLFNFCSALKKGSTYEDEIDNIKYIISKINEILAHNSPVLIIQRWTRGFLVRKKMSHLFLYKKHEKSISECEKRWIYKHKGFDNKLFKELFFQPGTNITEKFARWKHSIYSPVDLKYSTEKRKHVSSILYELKTRKPRYLIQKGQKESEDETEDEELDVSFRISVFKLPIHTLDSLRYAALLRAKEQDYFPTYAQPFSPAHQKPVVKIKDKLMGKKIRREFLATHRAGMKLQPLCDVDKYFSEQKKQESSKNKVTAVSMAQMAQERSRINIRENLNNKIYATHKLTARDDEIIQDGLQQLYQDRSSYLEKVKERRAQFLEEKKQKAKDRLLIQNLNNERTLLTKGMIAIDRLKNKQAALKEKSLIVQQKLATEKYQRDLLKQMKEIRAQEIHKRHCEEKFVYDMIAFQKACERLQDARTKAAIVKKNLVTKVPDGMTK", "length": 618, "header": "tr|A0AAA9SCI3-1|A0AAA9SCI3_BOVIN Isoform 1 of Leucine rich repeats and IQ motif containing 3 OS=Bos taurus OX=9913 GN=LRRIQ3 PE=4 SV=1 CANONICAL=A0AAA9SCI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3/entry#A0AAA9SCI3-1", "sequence": { "sequence": "MFHGTIIEELTNHREWSHYNENIIEDQKDFVFVKFSGLHLKSMENLQSCISLRVCIFSNNFITDIRPLQSCMKLIKLDLHGNQIKSLPDTKFWSGLKNLKLLYLHDNGFAKLKNLCMLSACPSLIALTMFDCPVSLKKGYRHVLVNSIWTLKALDHHVISDEEIIQNWHLPERFKTYNHRLLFNFCSALKKGSTYEDEIDNIKYIISKINEILAHNSPVLIIQRWTRGFLVRKKMSHLFLYKKHEKSISECEKRWIYKHKGFDNKLFKELFFQPGTNITEKFARWKHSIYSPVDLKYSTEKRKHVSSILYELKTRKPRYLIQKGQKESEDETEDEELDVSFRISVFKLPIHTLDSLRYAALLRAKEQDYFPTYAQPFSPAHQKPVVKIKDKLMGKKIRREFLATHRAGMKLQPLCDVDKYFSEQKKQESSKNKVTAVSMAQMAQERSRINIRENLNNKIYATHKLTARDDEIIQDGLQQLYQDRSSYLEKVKERRAQFLEEKKQKAKDRLLIQNLNNERTLLTKGMIAIDRLKNKQAALKEKSLIVQQKLATEKYQRDLLKQMKEIRAQEIHKRHCEEKFVYDMIAFQKACERLQDARTKAAIVKKNLVTKVPDGMTK", "length": 618, "header": "tr|A0AAA9SCI3-1|A0AAA9SCI3_BOVIN Isoform 1 of Leucine rich repeats and IQ motif containing 3 OS=Bos taurus OX=9913 GN=LRRIQ3 PE=4 SV=1 CANONICAL=A0AAA9SCI3-1" }, "locus": { "chromosome": "3", "start_pos": 70817716, "end_pos": 70627499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098532.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098532.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079956.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079956.1" } ] } }, { "isoform_ac": "A0AAA9TUE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3/entry#A0AAA9TUE9-1", "sequence": { "sequence": "MFHGTIIEELTNHREWSHYNENIIEDQKDFVFVKFSGLHLKSMENLQSCISLRVCIFSNNFITDIRPLQSCMKLIKLDLHGNQGSTYEDEIDNIKYIISKINEILAHNSPVLIIQRWTRGFLVRKKMSHLFLYKKHEKSISECEKRWIYKHKGFDNKLFKELFFQPGTNITEKFARWKHGKKKLWVNFH", "length": 189, "header": "tr|A0AAA9TUE9-1|A0AAA9TUE9_BOVIN Computationally mapped isoform of Leucine rich repeats and IQ motif containing 3 OS=Bos taurus OX=9913 GN=LRRIQ3 PE=4 SV=1 CANONICAL=A0AAA9SCI3-1" }, "locus": { "chromosome": "3", "start_pos": 70718198, "end_pos": 70627499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115526.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115526.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101994.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101994.1" } ] } }, { "isoform_ac": "F1MPB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI3/entry#F1MPB9-1", "sequence": { "sequence": "MFHGTIIEELTNHREWSHYNENIIEDQKDFVFVKFSGLHLKSMENLQSCISLRVCIFSNNFITDIRPLQSCMKLIKLDLHGNQVLLLLLQIKSLPDTKFWSGLKNLKLLYLHDNGFAKLKNLCMLSACPSLIALTMFDCPVSLKKGYRHVLVNSIWTLKALDHHVISDEEIIQNWHLPERFKTYNHRLLFNFCSALKKGSTYEDEIDNIKYIISKINEILAHNSPVLIIQRWTRGFLVRKKMSHLFLYKKHEKSISECEKRWIYKHKGFDNKLFKELFFQPGTNITEKFARWKHGKKKLWVNFH", "length": 304, "header": "tr|F1MPB9-1|A0AAA9SCI3_BOVIN Computationally mapped isoform of Leucine rich repeats and IQ motif containing 3 OS=Bos taurus OX=9913 GN=LRRIQ3 PE=4 SV=1 CANONICAL=A0AAA9SCI3-1" }, "locus": { "chromosome": "3", "start_pos": 70718198, "end_pos": 70627499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025849.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025849.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025849.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025849.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523789", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523789", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCI9-1", "uniprot_ac": "A0AAA9SCI9", "uniprot_id": "A0AAA9SCI9_BOVIN", "mass": { "chemical_mass": 34409.0, "monoisotopic_mass": 34409.0 }, "refseq": { "ac": "NP_001377179", "name": "olfactory receptor family 7 subfamily A member 121", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377179" }, "gene_names": [ { "name": "OR7A121", "type": "recommended", "evidence": [ { "id": "A0AAA9SCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9" } ] }, { "name": "OR7A121", "type": "synonym", "evidence": [ { "id": "NP_001377179", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377179" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 7 subfamily A member 121", "type": "synonym", "evidence": [ { "id": "A0AAA9SCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 7 subfamily A member 121", "type": "synonym", "evidence": [ { "id": "NP_001377179", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377179" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377179" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7A121", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9", "locus": { "chromosome": "7", "start_pos": 8651214, "end_pos": 8650291, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065609", "url": "https://www.ensembl.org/id/ENSBTAG00000065609" } ] } } ], "crossref": [ { "id": "A0AAA9SCI9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618007", "url": "https://www.ncbi.nlm.nih.gov/gene/618007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377179", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPRNLTHVSEFLLLGFSEEPELQPLIFGPFLSMYLITVFGNLLIILAVSSDPHLHTPMYFLLSNLSFVDICITSTITPKMLCNTQTQSHIITYEGCMIQMYFFMLFAGLDDFLLTVMAYDRFVAICHPLHYTVIMNPQHCGILVLVSCIISVLHSLLETLMVLTLSFCREVEIPHYFCELKQLIQLACSNNFLNELVMNCAAGLLGGVPLAAILYTYCKIASSICRISSAQGKYKAFSTCASHLSVVFLFYCTCLGVYLSSAAPHNPHSSATASVMYTMVTPMLNPFIYSLRNRDIKRALRALFQL", "length": 307, "header": "tr|A0AAA9SCI9-1|A0AAA9SCI9_BOVIN Isoform 1 of Olfactory receptor family 7 subfamily A member 121 OS=Bos taurus OX=9913 GN=OR7A121 PE=3 SV=1 CANONICAL=A0AAA9SCI9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9/entry#A0AAA9SCI9-1", "sequence": { "sequence": "MVPRNLTHVSEFLLLGFSEEPELQPLIFGPFLSMYLITVFGNLLIILAVSSDPHLHTPMYFLLSNLSFVDICITSTITPKMLCNTQTQSHIITYEGCMIQMYFFMLFAGLDDFLLTVMAYDRFVAICHPLHYTVIMNPQHCGILVLVSCIISVLHSLLETLMVLTLSFCREVEIPHYFCELKQLIQLACSNNFLNELVMNCAAGLLGGVPLAAILYTYCKIASSICRISSAQGKYKAFSTCASHLSVVFLFYCTCLGVYLSSAAPHNPHSSATASVMYTMVTPMLNPFIYSLRNRDIKRALRALFQL", "length": 307, "header": "tr|A0AAA9SCI9-1|A0AAA9SCI9_BOVIN Isoform 1 of Olfactory receptor family 7 subfamily A member 121 OS=Bos taurus OX=9913 GN=OR7A121 PE=3 SV=1 CANONICAL=A0AAA9SCI9-1" }, "locus": { "chromosome": "7", "start_pos": 8651211, "end_pos": 8650291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126574.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126574.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083102.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083102.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618007", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCI9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCJ5-1", "uniprot_ac": "A0AAA9SCJ5", "uniprot_id": "A0AAA9SCJ5_BOVIN", "mass": { "chemical_mass": 43090.0, "monoisotopic_mass": 43090.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Thyrotropin-releasing hormone receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SCJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5/entry#names_and_taxonomy" } ] }, { "name": "Thyroliberin receptor", "type": "synonym", "evidence": [ { "id": "A0AAA9SCJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5#function" }, { "database": "UniProtKB", "id": "ARBA00004100", "url": "https://www.uniprot.org/uniprotkb/ARBA00004100#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SCJ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46061", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46061", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46061:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46061:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCTMSLAPNEAVLGPAYKVVSVFLVLPMCVVGIVGNAMVVLVVLTTRDMHTPTSCYLVSLALADLTVLVAAGLPNVSESLAGQWVYCGCLGITYLQHLGINASSCSILVFTVERYIAICHPMQAQTMCTTARAKRVMVGIWGTTSVYCLLWFFLVDLDAGGLYLPIYLLDFTVFFLTSLLAATVLYGLIARILFRSALEHLPQLGDQHGDSEAQPEARALGRQPCEPGGVPSCLQVTKMLVVVVLLFAVLWMPYRTLVLLNSFVAQPFLDPWVLHFCHTCMYANSAINPIIYSLMSQKFRAAFWRLCQCGSEGPQRCTAGLSTASCSMVRETPPESTDQWERGCWPSGTRFVDHCLLHPGMEGSSQRGTARPQASCSQAPSLFWVEHCSQRH", "length": 393, "header": "tr|A0AAA9SCJ5-1|A0AAA9SCJ5_BOVIN Isoform 1 of Thyrotropin-releasing hormone receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SCJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5/entry#A0AAA9SCJ5-1", "sequence": { "sequence": "MTCTMSLAPNEAVLGPAYKVVSVFLVLPMCVVGIVGNAMVVLVVLTTRDMHTPTSCYLVSLALADLTVLVAAGLPNVSESLAGQWVYCGCLGITYLQHLGINASSCSILVFTVERYIAICHPMQAQTMCTTARAKRVMVGIWGTTSVYCLLWFFLVDLDAGGLYLPIYLLDFTVFFLTSLLAATVLYGLIARILFRSALEHLPQLGDQHGDSEAQPEARALGRQPCEPGGVPSCLQVTKMLVVVVLLFAVLWMPYRTLVLLNSFVAQPFLDPWVLHFCHTCMYANSAINPIIYSLMSQKFRAAFWRLCQCGSEGPQRCTAGLSTASCSMVRETPPESTDQWERGCWPSGTRFVDHCLLHPGMEGSSQRGTARPQASCSQAPSLFWVEHCSQRH", "length": 393, "header": "tr|A0AAA9SCJ5-1|A0AAA9SCJ5_BOVIN Isoform 1 of Thyrotropin-releasing hormone receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SCJ5-1" }, "locus": { "chromosome": "18", "start_pos": 13820689, "end_pos": 13815049, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129843.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129843.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079972.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079972.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "thyrotropin-releasing hormone receptor activity", "id": "GO:0004997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004997", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 293, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE35-1", "uniprot_ac": "A0AAA9SE35", "uniprot_id": "A0AAA9SE35_BOVIN", "mass": { "chemical_mass": 21871.0, "monoisotopic_mass": 21871.0 }, "refseq": {}, "gene_names": [ { "name": "GPX2", "type": "recommended", "evidence": [ { "id": "A0AAA9SE35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35" } ] } ], "protein_names": [ { "name": "Glutathione peroxidase", "type": "recommended", "evidence": [ { "id": "A0AAA9SE35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. Cannot reduce phosphatidycholine hydroperoxide.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35#function" }, { "database": "UniProtKB", "id": "ARBA00046108", "url": "https://www.uniprot.org/uniprotkb/ARBA00046108#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35", "locus": { "chromosome": "10", "start_pos": 77069493, "end_pos": 77073946, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068964", "url": "https://www.ensembl.org/id/ENSBTAG00000068964" } ] } } ], "crossref": [ { "id": "A0AAA9SE35", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE35", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16833", "url": "https://www.rhea-db.org/rhea/16833", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19057", "url": "https://www.rhea-db.org/rhea/19057", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48620", "url": "https://www.rhea-db.org/rhea/48620", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48888", "url": "https://www.rhea-db.org/rhea/48888", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69412", "url": "https://www.rhea-db.org/rhea/69412", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "69651", "url": "https://www.rhea-db.org/rhea/69651", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "76691", "url": "https://www.rhea-db.org/rhea/76691", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "76695", "url": "https://www.rhea-db.org/rhea/76695", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGFQPTFTLVQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI", "length": 189, "header": "tr|A0AAA9SE35-1|A0AAA9SE35_BOVIN Isoform 1 of Glutathione peroxidase OS=Bos taurus OX=9913 GN=GPX2 PE=3 SV=2 CANONICAL=A0AAA9SE35-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35/entry#A0AAA9SE35-1", "sequence": { "sequence": "MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGFQPTFTLVQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI", "length": 189, "header": "tr|A0AAA9SE35-1|A0AAA9SE35_BOVIN Isoform 1 of Glutathione peroxidase OS=Bos taurus OX=9913 GN=GPX2 PE=3 SV=2 CANONICAL=A0AAA9SE35-1" }, "locus": { "chromosome": "10", "start_pos": 77072951, "end_pos": 77069817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133986.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133986.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080643.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080643.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glutathione peroxidase activity", "id": "GO:0004602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35" } ], "pmid": "" }, { "name": "phospholipid-hydroperoxide glutathione peroxidase activity", "id": "GO:0047066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16833", "name": "", "equation": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1", "P37141-1", "F1N076-1", "A0A3Q1M314-1" ], "evidence": [ { "id": "16833", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16833" } ] }, { "id": "19057", "name": "", "equation": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1" ], "evidence": [ { "id": "19057", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19057" } ] }, { "id": "48620", "name": "", "equation": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q95L14-1", "Q2KJG4-1", "P00435-1", "Q9N2J2-1", "Q3T100-1" ], "evidence": [ { "id": "48620", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48620" } ] }, { "id": "48888", "name": "", "equation": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1", "Q28035-1" ], "evidence": [ { "id": "48888", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48888" } ] }, { "id": "69412", "name": "", "equation": "tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1", "P37141-1" ], "evidence": [ { "id": "69412", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69412" } ] }, { "id": "69651", "name": "", "equation": "cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1" ], "evidence": [ { "id": "69651", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/69651" } ] }, { "id": "76691", "name": "", "equation": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1" ], "evidence": [ { "id": "76691", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76691" } ] }, { "id": "76695", "name": "", "equation": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00435-1", "Q9N2J2-1" ], "evidence": [ { "id": "76695", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/76695" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M314", "gene_name": "HEPH", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "A0A3Q1M314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M314" } ] } ] }, { "uniprot_ac": "F1N076", "gene_name": "CP", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O.", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.16.3.4", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "F1N076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N076" } ] } ] }, { "uniprot_ac": "P00435", "gene_name": "GPX1", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P00435", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00435" } ] } ] }, { "uniprot_ac": "P37141", "gene_name": "GPX3", "activity": [ { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "P37141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P37141" } ] }, { "ec_number": "1.11.1.9", "activity": "", "evidence": [ { "id": "P37141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P37141" } ] } ] }, { "uniprot_ac": "Q28035", "gene_name": "GSTA1", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "5.3.3.-", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q28035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28035" } ] } ] }, { "uniprot_ac": "Q2KJG4", "gene_name": "MGST2", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = leukotriene A4 + glutathione.", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] }, { "ec_number": "4.4.1.20", "activity": "", "evidence": [ { "id": "Q2KJG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG4" } ] } ] }, { "uniprot_ac": "Q3T100", "gene_name": "MGST3", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q3T100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T100" } ] }, { "ec_number": "4.4.1.20", "activity": "leukotriene C4 = leukotriene A4 + glutathione.", "evidence": [ { "id": "Q3T100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T100" } ] }, { "ec_number": "2.5.1.-", "activity": "", "evidence": [ { "id": "Q3T100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T100" } ] }, { "ec_number": "4.4.1.20", "activity": "", "evidence": [ { "id": "Q3T100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T100" } ] } ] }, { "uniprot_ac": "Q95L14", "gene_name": "PTGES", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "5.3.99.3", "activity": "prostaglandin H2 = prostaglandin E2.", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "5.3.99.3", "activity": "", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "Q95L14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L14" } ] } ] }, { "uniprot_ac": "Q9N2J2", "gene_name": "GPX4", "activity": [ { "ec_number": "1.11.1.12", "activity": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O.", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] }, { "ec_number": "1.11.1.9", "activity": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O.", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] }, { "ec_number": "1.11.1.12", "activity": "", "evidence": [ { "id": "Q9N2J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N2J2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCL5-1", "uniprot_ac": "A0AAA9SCL5", "uniprot_id": "A0AAA9SCL5_BOVIN", "mass": { "chemical_mass": 22568.0, "monoisotopic_mass": 22568.0 }, "refseq": {}, "gene_names": [ { "name": "DNAJC5G", "type": "recommended", "evidence": [ { "id": "A0AAA9SCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5" } ] } ], "protein_names": [ { "name": "DnaJ heat shock protein family (Hsp40) member C5 gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9SCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC5G", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5", "locus": { "chromosome": "11", "start_pos": 72359146, "end_pos": 72365723, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018262", "url": "https://www.ensembl.org/id/ENSBTAG00000018262" } ] } } ], "crossref": [ { "id": "A0AAA9SCL5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616608", "url": "https://www.ncbi.nlm.nih.gov/gene/616608", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44027:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44027:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLV5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHVDEAARQLSKSGSTLYAVLELKKGASPEDVKKAYRDLSLSFIITLSPLPLPSSAHPSFGYCLARRLALKYHPDKNPGDAQAAEIFKEINTAHAVLSDPKKRKIYDRHGSLGIYIYDHFGEEGVTYYFTMNSCWFKTLVLLCALLTCCCCCCCCCFCCGALKPPPEEMANKKNASNVQHQPPRSGHREHFRRGEDGSSDDN", "length": 203, "header": "tr|A0AAA9SCL5-1|A0AAA9SCL5_BOVIN Isoform 1 of DnaJ heat shock protein family (Hsp40) member C5 gamma OS=Bos taurus OX=9913 GN=DNAJC5G PE=4 SV=1 CANONICAL=A0AAA9SCL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5/entry#A0AAA9SCL5-1", "sequence": { "sequence": "MAHVDEAARQLSKSGSTLYAVLELKKGASPEDVKKAYRDLSLSFIITLSPLPLPSSAHPSFGYCLARRLALKYHPDKNPGDAQAAEIFKEINTAHAVLSDPKKRKIYDRHGSLGIYIYDHFGEEGVTYYFTMNSCWFKTLVLLCALLTCCCCCCCCCFCCGALKPPPEEMANKKNASNVQHQPPRSGHREHFRRGEDGSSDDN", "length": 203, "header": "tr|A0AAA9SCL5-1|A0AAA9SCL5_BOVIN Isoform 1 of DnaJ heat shock protein family (Hsp40) member C5 gamma OS=Bos taurus OX=9913 GN=DNAJC5G PE=4 SV=1 CANONICAL=A0AAA9SCL5-1" }, "locus": { "chromosome": "11", "start_pos": 72362278, "end_pos": 72360376, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132731.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132731.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083129.1" } ] } }, { "isoform_ac": "A0AAF6DLV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5/entry#A0AAF6DLV5-1", "sequence": { "sequence": "MRIKGDNKIMAHVDEAARQLSKSGSTLYAVLELKKGASPEDVKKAYRRLALKYHPDKNPGDAQAAEIFKEINTAHAVLSDPKKRKIYDRHGSLGIYIYDHFGEEGVTYYFTMNSCWFKTLVLLCALLTCCCCCCCCCFCCGALKPPPEEMANKKNASNVQHQPPRSGHREHFRRGEDGSSDDN", "length": 183, "header": "tr|A0AAF6DLV5-1|A0AAF6DLV5_BOVIN Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member C5 gamma OS=Bos taurus OX=9913 GN=DNAJC5G PE=4 SV=1 CANONICAL=A0AAA9SCL5-1" }, "locus": { "chromosome": "11", "start_pos": 72365691, "end_pos": 72360376, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024305.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024305.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024305.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024305.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCL5" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 111, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 175, "end_pos": 177 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCN2-1", "uniprot_ac": "A0AAA9SCN2", "uniprot_id": "A0AAA9SCN2_BOVIN", "mass": { "chemical_mass": 73598.0, "monoisotopic_mass": 73598.0 }, "refseq": { "ac": "XP_024855952", "name": "growth arrest-specific protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855952" }, "gene_names": [ { "name": "GAS6", "type": "recommended", "evidence": [ { "id": "A0AAA9SCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ] }, { "name": "GAS6", "type": "synonym", "evidence": [ { "id": "XP_024855952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855952" } ] } ], "protein_names": [ { "name": "Growth arrest-specific protein 6", "type": "recommended", "evidence": [ { "id": "A0AAA9SCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2/entry#names_and_taxonomy" } ] }, { "name": "AXL receptor tyrosine kinase ligand", "type": "synonym", "evidence": [ { "id": "A0AAA9SCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2/entry#names_and_taxonomy" } ] }, { "name": "growth arrest-specific protein 6", "type": "synonym", "evidence": [ { "id": "XP_024855952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855952" } ] } ], "function": [ { "annotation": "Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MAA6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA6#function" }, { "database": "UniProtKB", "id": "ARBA00058789", "url": "https://www.uniprot.org/uniprotkb/ARBA00058789#function" }, { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2#function" }, { "database": "UniProtKB", "id": "F1MZ40", "url": "https://www.uniprot.org/uniprotkb/F1MZ40#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2", "locus": { "chromosome": "12", "start_pos": 86809929, "end_pos": 86838871, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019964", "url": "https://www.ensembl.org/id/ENSBTAG00000019964" } ] } } ], "crossref": [ { "id": "A0AAA9SCN2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCN2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019964", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019964", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504526", "url": "https://www.ncbi.nlm.nih.gov/gene/504526", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504526", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504526", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PIINHGM", "url": "https://omabrowser.org/oma/group/PIINHGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAA6", "url": "https://www.orthodb.org/?gene=A0A3Q1MAA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MZ40", "url": "https://www.orthodb.org/?gene=F1MZ40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24040:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24040:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00054", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00054", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-159763", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159763", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-159782", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159782", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202733", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855952", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ40", "url": "https://www.uniprot.org/uniprotkb/F1MZ40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ40-1", "url": "https://www.uniprot.org/uniprotkb/F1MZ40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPGPAAALGTALLLLLLASESAHTVMLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEELCSREEAREVFENDPETEYFYPRYLECINKHGSPYQKNPAFVTCVQKLPDQCSPDPCNKKGTHVCQDLMGNFYCQCRDGWAGRLCDRDVNECSQENGGCSQICYNQPGSFQCACHGGYMLSPDSRTCLDVDECVDAGACGAARCQNLPGSYSCVCDEGYVFSSQEKGCQDTDECVEGRCEQVCANSPGSYTCHCDGRGGLKLSQDMSTCEDILPCVPFNVAKSVNSLYLGRMFSAMPVIKLLFKRLQPTRLVAEFDFRTFDPEGILFFAGGHRDSTWIVLGLRAGRLELQLRYQGVGRVTSSGPVINHGSWQTISVEELERNLVIKVNKDAVMKIAVAGDLFQLDRGLYHLNLTVGGIPFQEKDLVHPMNPRLDGCLKSWHWLDGEDTAVQETVKANVKMQCFSVTERGSFFPGSGFAFFHLDYARMSPAGGTKTTWAVEAVARVRPAADTGVLLALVGDHQAVALSVALVDYHSTKKLKKQLVVLAVEGVTLVLMEIKVCDGQEHVVTISVNKDRATLEVDGTQGQSEVSPAGLQEQLAILGRHLEGSVLTFIGGLPDVPVTSAPVTAFYRGCMTLEVNRKALDLDEAAYKHSDITSHSCPPVEPAA", "length": 671, "header": "tr|A0AAA9SCN2-1|A0AAA9SCN2_BOVIN Isoform 1 of Growth arrest-specific protein 6 OS=Bos taurus OX=9913 GN=GAS6 PE=4 SV=1 CANONICAL=A0AAA9SCN2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2/entry#A0A3Q1MAA6-1", "sequence": { "sequence": "MPPGPAAALGTALLLLLLASESAHTVMLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEELCSREEAREVFENDPETEYFYPRYLECINKHGSPYQKNPAFVTCVQKLPDQCSPDPCNKKGTHVCQDLMGNFYCQCRDGWAGRLCDRDVNECSQENGGCSQICYNQPGSFQCACHGGYMLSPDSRTCLDVDECVDAGACGAARCQNLPGSYSCVCDEGYVFSSQEKGCQDTDECVEGRCEQVCANSPGSYTCHCDGRGGLKLSQDMSTCEDILPCVPFNVAKSVNSLYLGRMFSAMPVIKLLFKRLQPTRLVAEFDFRTFDPEGILFFAGGHRDSTWIVLGLRAGRLELQLRYQGVGRVTSSGPVINHGSWQTISVEELERNLVIKVNKDAVMKIAVAGDLFQLDRGLYHLNLTVGGIPFQEKDLVHPMNPRLDGCLKSWHWLDGEDTAVQETVKANVKMQCFSVTERGSFFPGSGFAFFHLDYARMSPAGGTKTTWAVEAVARVRPAADTGVLLALVGDHQAVALSVALVDYHSTKKLKKQLVVLAVEGVTLVLMEIKVCDGQEHVVTISVNKDRATLEVDGTQGQSEVSPAGLQEQLAILGRHLEGSVLTFIGGLPGTPPWVSDGGSRPHGEPGSPVPHPRGLVSSCLGKQARRARDLGSGHGLLPRLHDAGGQPEGAGPGRSRLQAQRHHVPLLPSRRARRLGFWAADAPPHARRSLLSTRRMAAAPAPALETLNPRPPSPSGPPCPRVTYVYIED", "length": 762, "header": "tr|A0A3Q1MAA6-1|A0A3Q1MAA6_BOVIN Computationally mapped isoform of Growth arrest-specific protein 6 OS=Bos taurus OX=9913 GN=GAS6 PE=4 SV=2 CANONICAL=A0AAA9SCN2-1" }, "locus": { "chromosome": "12", "start_pos": 86838651, "end_pos": 86810461, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065463.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065463.2" } ] } }, { "isoform_ac": "A0AAA9SCN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2/entry#A0AAA9SCN2-1", "sequence": { "sequence": "MPPGPAAALGTALLLLLLASESAHTVMLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEELCSREEAREVFENDPETEYFYPRYLECINKHGSPYQKNPAFVTCVQKLPDQCSPDPCNKKGTHVCQDLMGNFYCQCRDGWAGRLCDRDVNECSQENGGCSQICYNQPGSFQCACHGGYMLSPDSRTCLDVDECVDAGACGAARCQNLPGSYSCVCDEGYVFSSQEKGCQDTDECVEGRCEQVCANSPGSYTCHCDGRGGLKLSQDMSTCEDILPCVPFNVAKSVNSLYLGRMFSAMPVIKLLFKRLQPTRLVAEFDFRTFDPEGILFFAGGHRDSTWIVLGLRAGRLELQLRYQGVGRVTSSGPVINHGSWQTISVEELERNLVIKVNKDAVMKIAVAGDLFQLDRGLYHLNLTVGGIPFQEKDLVHPMNPRLDGCLKSWHWLDGEDTAVQETVKANVKMQCFSVTERGSFFPGSGFAFFHLDYARMSPAGGTKTTWAVEAVARVRPAADTGVLLALVGDHQAVALSVALVDYHSTKKLKKQLVVLAVEGVTLVLMEIKVCDGQEHVVTISVNKDRATLEVDGTQGQSEVSPAGLQEQLAILGRHLEGSVLTFIGGLPDVPVTSAPVTAFYRGCMTLEVNRKALDLDEAAYKHSDITSHSCPPVEPAA", "length": 671, "header": "tr|A0AAA9SCN2-1|A0AAA9SCN2_BOVIN Isoform 1 of Growth arrest-specific protein 6 OS=Bos taurus OX=9913 GN=GAS6 PE=4 SV=1 CANONICAL=A0AAA9SCN2-1" }, "locus": { "chromosome": "12", "start_pos": 86838651, "end_pos": 86810625, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092193.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092193.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083881.1" } ] } }, { "isoform_ac": "F1MZ40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2/entry#F1MZ40-1", "sequence": { "sequence": "MPPGPAAALGTALLLLLLASESAHTVMLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEELCSREEAREVFENDPETEYFYPRYLECINKHGSPYQKNPAFVTCVQKLPDQCSPDPCNKKGTHVCQDLMGNFYCQCRDGWAGRLCDRDVDECVDAGACGAARCQNLPGSYSCVCDEGYVFSSQEKGCQDTDECVEGRCEQVCANSPGSYTCHCDGRGGLKLSQDMSTCEDILPCVPFNVAKSVNSLYLGRMFSAMPVIKLLFKRLQPTRLVAEFDFRTFDPEGILFFAGGHRDSTWIVLGLRAGRLELQLRYQGVGRVTSSGPVINHGSWQTISVEELERNLVIKVNKDAVMKIAVAGDLFQLDRGLYHLNLTVGGIPFQEKDLVHPMNPRLDGCLKSWHWLDGEDTAVQETVKANVKMQCFSVTERGSFFPGSGFAFFHLDYARMSPAGGTKTTWAVEAVARVRPAADTGVLLALVGDHQAVALSVALVDYHSTKKLKKQLVVLAVEGVTLVLMEIKVCDGQEHVVTISVNKDRATLEVDGTQGQSEVSPAGLQEQLAILGRHLEGSVLTFIGGLPDVPVTSAPVTAFYRGCMTLEVNRKALDLDEAAYKHSDITSHSCPPVEPAA", "length": 630, "header": "tr|F1MZ40-1|F1MZ40_BOVIN Computationally mapped isoform of Growth arrest-specific protein 6 OS=Bos taurus OX=9913 GN=GAS6 PE=4 SV=4 CANONICAL=A0AAA9SCN2-1" }, "locus": { "chromosome": "12", "start_pos": 86838651, "end_pos": 86810625, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035307.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035307.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035185.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035185.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504526", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504526", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-159763", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159763", "resource": "Reactome", "description": "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus" }, { "id": "R-BTA-159782", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159782", "resource": "Reactome", "description": "Removal of aminoterminal propeptides from gamma-carboxylated proteins" }, { "id": "R-BTA-202733", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202733", "resource": "Reactome", "description": "Cell surface interactions at the vascular wall" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AYJ5-1", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "AMPPPPPGPAAALGTALLLILLASESAPTVMLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECIEELCSQEEAREVFENDPETEYFYPRYLECISKHGSPYTKNPDFVSCVQKLPDQCSPDPCDKEGTQVCQDLMGNFYCQCRDGWGGRLCDRDVNECSQQNGGCSHVCYNKLGSFHCACYSGYALSPDSRTCHDVDECADAGACGEARCQNLPGSYSCLCDEGYAFHAQEKACRDVDECAEGRCEQACVNSPGSYTCHCDGRGGLKLSQDMSTCEDILPCVPFNVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGVLFFAGGRQDSTWIVLGLRAGRLELQLRYQGVGRVTSSGPVINHGVWQTISVEELERNLVVKVNRDAVMKIAVAGELFQLDRGLYHLNLTVGGIPFKEKDLVQPMNPRLDGCMRSWNWLNGEDTTIQETVRVNAKMQCFSLTERGSFFPGTGFALYSLDYARTSPDIGAETFWEVEAVARIRPATDTGVLLALVGGDQAVVLSVALVDYHSTKKLKKQLVVLAAESVTLALMEIKVCDGQEHVVTVSVNKDEATLEVDGTRGQRDVSPAGLQERLVLLGRHLQGSVLTFIGGLPDVPVTSAPVTAFYRGCMTLEVNGKALDLDEATYKHSDITAHSCPPVEPAA", "length": 675 }, "evidence": [ { "id": "A0AAA9SCN2", "url": "https://omabrowser.org/oma/group/A0AAA9SCN2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YVP9-1", "protein_name": "Growth arrest specific 6", "gene_name": "GAS6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGERLPRRARQDPRSPPAPLLSAPLRRTMPQPLGAALLLALLAADCSQAVLLRAPEAAQFLRQRQRRAYQIFEETKQGHLERECVEEHCSKEEAREVFENDPETEYFYPKYLACIHKYGSPYTRSPDFLTCVHNLPNQCSPDPCYKEGTVRCEDLKGDFYCECKRGWQGKTCDKDIDECKVQHGGCNQICLNKLGSYRCSCYSGYALKDSKTCEDIDECAASADICGEARCKNLISSYECVCDAGYRYDEQRKTCDDINECEERLCEQMCVNLPGSYTCHCDGRGGVKLSQDMNTCENIIPCVPFAVAKSVKSLYLGRMFSGTPVIRLRFKRKQLTRLVAEFDFRTFDPEGILFFAGGHQDSTWVVLALRKGRLELQLKYSGIGRVTSSGPLINHGMWQTISVEELERSLVVKVNRDAVMRIAVSGDLFTLDKGLYQLNLTVGGIPFKTKDLIVPINPRLDGCLRAWNWLNGEDSTIQETIKMNERMQCFAVAGRGSFYPGRGFAIFNLTYMQPSSGNETKTSWKIEVNAVIQPATDTGVMFALVTEDASVPLSLSLVDYHSTKKLKQQFVILAVEDTVVSRLALNLCDKKEHSVDILLKKDQLSLRVDGMEGERELSTSELEDSLSILESSLQSPVKTYVGGLPDVNVTATPVTAFYHGCMTVKLRSKALDLDEALYKHSDITSHSCPPVEAGP", "length": 695 }, "evidence": [ { "id": "A0AAA9SCN2", "url": "https://omabrowser.org/oma/group/A0AAA9SCN2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA", "length": 678 }, "evidence": [ { "id": "A0AAA9SCN2", "url": "https://omabrowser.org/oma/group/A0AAA9SCN2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61592-1", "protein_name": "Growth arrest-specific protein 6", "gene_name": "Gas6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPPPGPAAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQECMRKYGRPEEKNPDFAKCVQNLPDQCTPNPCDKKGTHICQDLMGNFFCVCTDGWGGRLCDKDVNECVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTCQDIDECTDSDTCGDARCKNLPGSYSCLCDEGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLERGLYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFATYRLNYTRTSLDVGTETTWEVKVVARIRPATDTGVLLALVGDDDVVPISVALVDYHSTKKLKKQLVVLAVEDVALALMEIKVCDSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHLQGSVHTYVGGLPEVSVISAPVTAFYRGCMTLEVNGKILDLDTASYKHSDITSHSCPPVEHATP", "length": 674 }, "evidence": [ { "id": "A0AAA9SCN2", "url": "https://omabrowser.org/oma/group/A0AAA9SCN2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63772-1", "protein_name": "Growth arrest-specific protein 6", "gene_name": "Gas6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPPPGPTAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETDYFYPRYQECMRKYGRPEDKNPNFATCVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQKNGGCSQVCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKNLPGSYSCLCDKGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELDRNLVIKVNKDAVMKIAVAGGLFQLERGLYHLNLTVGGIPFKESDLVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEVEVVARIRPATDTGVLMALVGDKDVVLLSVALVDYHSTKKLKKQLVVLAVENVALALMEIKVCDSQEHTVTVSLRDGEATLEVDGTKGQSEVSTAQLQERLDLLKTRLQGSVLTFVGGLPDVQVTSTPVTAFYRGCMTLEVNGKTLDLDTASYKHSDITSHSCPPVEHVTA", "length": 674 }, "evidence": [ { "id": "A0AAA9SCN2", "url": "https://omabrowser.org/oma/group/A0AAA9SCN2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 49, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cellular response to nutrient levels", "id": "GO:0031669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "apoptotic cell clearance", "id": "GO:0043277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of fibroblast apoptotic process", "id": "GO:2000270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cellular response to interferon-alpha", "id": "GO:0035457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of cytokine-mediated signaling pathway", "id": "GO:0001961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001961", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cellular response to vitamin K", "id": "GO:0071307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "hematopoietic stem cell migration to bone marrow", "id": "GO:0097241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097241", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of oligodendrocyte apoptotic process", "id": "GO:1900142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900142", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of dendritic cell apoptotic process", "id": "GO:2000669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of type II interferon production", "id": "GO:0032689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032689", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor production", "id": "GO:0032720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of protein export from nucleus", "id": "GO:0046827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046827", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "B cell chemotaxis", "id": "GO:0035754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035754", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis", "id": "GO:0050766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell apoptotic process", "id": "GO:2000352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "symbiont entry into host cell", "id": "GO:0046718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046718", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "receptor-mediated virion attachment to host cell", "id": "GO:0046813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "calcium ion transmembrane transport", "id": "GO:0070588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070588", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor-mediated signaling pathway", "id": "GO:0010804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010804", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "viral genome replication", "id": "GO:0019079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019079", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of interleukin-1 production", "id": "GO:0032692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032692", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "dendritic cell differentiation", "id": "GO:0097028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097028", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of dendritic cell chemotaxis", "id": "GO:2000510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000510", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "fusion of virus membrane with host plasma membrane", "id": "GO:0019064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell differentiation", "id": "GO:0032825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032825", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of biomineral tissue development", "id": "GO:0070168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "extracellular matrix assembly", "id": "GO:0085029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0085029", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of renal albumin absorption", "id": "GO:2000533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000533", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of protein kinase activity", "id": "GO:0045860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045860", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "activation of protein kinase B activity", "id": "GO:0032148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032148", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of TOR signaling", "id": "GO:0032008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of fibroblast proliferation", "id": "GO:0048146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "positive regulation of glomerular filtration", "id": "GO:0003104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "receptor tyrosine kinase binding", "id": "GO:0030971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "id": "GO:0043027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 149, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" }, { "id": "PS50998", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50998" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Gla", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 89, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN2" }, { "id": "PS50025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin G", "eco_id": "ECO_0000259", "start_pos": 286, "end_pos": 465, "start_aa": "Ser", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 415, "end_pos": 417 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCP4-1", "uniprot_ac": "A0AAA9SCP4", "uniprot_id": "A0AAA9SCP4_BOVIN", "mass": { "chemical_mass": 15887.0, "monoisotopic_mass": 15887.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SCP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SCP4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DCGVTQT", "url": "https://omabrowser.org/oma/group/DCGVTQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23268:SF101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23268:SF101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSRLLCCVTLCLLGAGLVDSGVTQTPKYLIKSRKQQVILRCSPESGHLYVSWYQQALGQGPQFLIQYYNGKENEKGNMPDRFSGEQFSDSSSQMNLSSLELTDSAVYLCASSEDTALHDQVPVGQKHSCPSSGSGCEGDCLPSRPG", "length": 147, "header": "tr|A0AAA9SCP4-1|A0AAA9SCP4_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SCP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4/entry#A0AAA9SCP4-1", "sequence": { "sequence": "MGSRLLCCVTLCLLGAGLVDSGVTQTPKYLIKSRKQQVILRCSPESGHLYVSWYQQALGQGPQFLIQYYNGKENEKGNMPDRFSGEQFSDSSSQMNLSSLELTDSAVYLCASSEDTALHDQVPVGQKHSCPSSGSGCEGDCLPSRPG", "length": 147, "header": "tr|A0AAA9SCP4-1|A0AAA9SCP4_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SCP4-1" }, "locus": { "chromosome": "4", "start_pos": 105625567, "end_pos": 105624994, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117156.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117156.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080052.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080052.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0B4J1U6-1", "protein_name": "T cell receptor beta variable 9", "gene_name": "TRBV9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFRLLCCVAFCLLGAGPVDSGVTQTPKHLITATGQRVTLRCSPRSGDLSVYWYQQSLDQGLQFLIHYYNGEERAKGNILERFSAQQFPDLHSELNLSSLELGDSALYFCASSV", "length": 114 }, "evidence": [ { "id": "A0AAA9SCP4", "url": "https://omabrowser.org/oma/group/A0AAA9SCP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCP4" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 125, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCS6-1", "uniprot_ac": "A0AAA9SCS6", "uniprot_id": "A0AAA9SCS6_BOVIN", "mass": { "chemical_mass": 46484.0, "monoisotopic_mass": 46484.0 }, "refseq": { "ac": "NP_001193721", "name": "natural cytotoxicity triggering receptor 3 ligand 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193721" }, "gene_names": [ { "name": "NCR3LG1", "type": "recommended", "evidence": [ { "id": "A0AAA9SCS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6" } ] }, { "name": "B7H6", "type": "synonym", "evidence": [ { "id": "NP_001193721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193721" } ] }, { "name": "NCR3LG1", "type": "synonym", "evidence": [ { "id": "NP_001193721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193721" } ] } ], "protein_names": [ { "name": "B7 homolog 6", "type": "synonym", "evidence": [ { "id": "NP_001193721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193721" } ] }, { "name": "Natural killer cell cytotoxicity receptor 3 ligand 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SCS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6/entry#names_and_taxonomy" } ] }, { "name": "natural cytotoxicity triggering receptor 3 ligand 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193721", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193721" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCR3LG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6", "locus": { "chromosome": "15", "start_pos": 35121233, "end_pos": 35134228, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050060", "url": "https://www.ensembl.org/id/ENSBTAG00000050060" } ] } } ], "crossref": [ { "id": "A0AAA9SCS6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00098", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00098", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523303", "url": "https://www.ncbi.nlm.nih.gov/gene/523303", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523303", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523303", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NITWKRW", "url": "https://omabrowser.org/oma/group/NITWKRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR25466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25466:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25466:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193721", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKRAAGRMRWDSVWLLRLLMSVLVLERFQLVAGLLQVEMAGRTQMVFLNENVTIFCKIRDSPHLDIKSMGITWFQKTGKSETYTKLFQYFGNYRETSQRGAWVSLRSLQKGDASLQLPRVQLEDAGEYRCELVVTPQKAQGSVWLKVVAQPVSNLSEQVMVKDNKDRHILCTSSRFYPEHINITWKKWTQNDRHFREFSKNITTDHIVKNEDGTFNITSHLRLKPSLEDNGTIYQCVVWHVSLPTIQSLDFQLILHPESEKKTDWLSIGMIVVIIIGLIILLYIFLKTRSVKCWKWCLLKRVCAHVVQLFMTLWSVVCQAPLSMEFSKQEHWNGLPFPSPGAFPNPEIEPKSPAFQVDSLLLEPLGKLEDERHCKQRLLEDKGPSKLELDQMTASSTHQQI", "length": 402, "header": "tr|A0AAA9SCS6-1|A0AAA9SCS6_BOVIN Isoform 1 of Natural killer cell cytotoxicity receptor 3 ligand 1 OS=Bos taurus OX=9913 GN=NCR3LG1 PE=4 SV=1 CANONICAL=A0AAA9SCS6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6/entry#A0AAA9SCS6-1", "sequence": { "sequence": "MAKRAAGRMRWDSVWLLRLLMSVLVLERFQLVAGLLQVEMAGRTQMVFLNENVTIFCKIRDSPHLDIKSMGITWFQKTGKSETYTKLFQYFGNYRETSQRGAWVSLRSLQKGDASLQLPRVQLEDAGEYRCELVVTPQKAQGSVWLKVVAQPVSNLSEQVMVKDNKDRHILCTSSRFYPEHINITWKKWTQNDRHFREFSKNITTDHIVKNEDGTFNITSHLRLKPSLEDNGTIYQCVVWHVSLPTIQSLDFQLILHPESEKKTDWLSIGMIVVIIIGLIILLYIFLKTRSVKCWKWCLLKRVCAHVVQLFMTLWSVVCQAPLSMEFSKQEHWNGLPFPSPGAFPNPEIEPKSPAFQVDSLLLEPLGKLEDERHCKQRLLEDKGPSKLELDQMTASSTHQQI", "length": 402, "header": "tr|A0AAA9SCS6-1|A0AAA9SCS6_BOVIN Isoform 1 of Natural killer cell cytotoxicity receptor 3 ligand 1 OS=Bos taurus OX=9913 GN=NCR3LG1 PE=4 SV=1 CANONICAL=A0AAA9SCS6-1" }, "locus": { "chromosome": "15", "start_pos": 35133985, "end_pos": 35121553, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103095.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103095.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081662.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523303", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523303", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 133, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 202, "end_pos": 204 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCT4-1", "uniprot_ac": "A0AAA9SCT4", "uniprot_id": "A0AAA9SCT4_BOVIN", "mass": { "chemical_mass": 357524.0, "monoisotopic_mass": 357524.0 }, "refseq": {}, "gene_names": [ { "name": "CFAP47", "type": "recommended", "evidence": [ { "id": "A0AAA9SCT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4" } ] } ], "protein_names": [ { "name": "Calponin-homology (CH) domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SCT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4", "locus": {} } ], "crossref": [ { "id": "cd21218", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21218", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45912", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45912", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45912:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45912:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24529", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24529", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26579", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26579", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METERSSLVARDLDTTKKDMKLRVTPSEMKFRNAVAGRVYRLPLTVQNLGRSSQKIHFQEPVKPQFKLILTNLDKSLASGLQTTAMVEYHPDKNEDICDQLLISIGNKTIEVPLIGLIPSCQLEIEPEVNFGTLVASSKVYCKEINIINHGSVPGIFKTEYQGQLSIVIFPTSGVVQPKSSVVIKVDFCADQPIVVNELAKVSLQDRPDVFLNIRAHVVEQIIELLNINNDKKLECISFGSVFFGTSKIERALLYNNSPEPINWVAIMQDDSVGEELGTNIKQRTDVALNNLTYLRKIKSIDITTIISCVPNEGRLLPYQKSLISFCFSPKLIIDVQKNDPSHRQDYAVFLRFESVASKDGFLRDDNQIIKSGSFQKIELALTGSGLPVLLQFDPGRILNFAPCFMGGHSEIHCVMQNRSKSLPLMYHFKKTAHFKIDPQKGKIDEGCIQNVTCSFIPHQVGVFKVKQFIEIIGSVADENLQSSSLKPFHHIYLYFNSVCKPSTKKVVMKVNPGISPLVSNPTGQFVVKDLVQYKDHARVAMLQSTMTRIHNHKINKELLKDALIAFPNDRAASIRSGEDHENFRTIFTKIPRYNYVDPDFAYTKFEKIVKKSHDNYYVEYIKFLRNVRLQKEAHRKHIYSYNDIDIGLHPASGLKSPTVSEVEREEELPSTQYWIKHNQLLRTRNIAVKETKSLRRKVLKGLKSDPSTPYEKHDCSLTLTPKQIYQVIVGPSVLNFGDVCVNSTNTHLLHIINMLPIHILMQLDVSLEELKKTSQFSYVIPPTTNTYISVIFESPTIGKFWKSFTFTVNNMPGGHILVMAVVLPVRLQLSSNELILRPRGFLVKTCFRGTVRMYNHQNYFVKFEWQPINTGKGMAFSIRPAKGTVEPYCSLECEVTWQPGFDSPERGEFILHVSEGNTLKLKCLAHLGHSKVTFLEPRILFSNSPQGLTTWRKAILHNVGQNHAYFKVCDQSLLSMIHIVPSQGIIPLGGLTVLNISCTPTVKEKFDIRTKVAIRCAKDIDLRIGGSVEVADIEIHPNKFNFIGTYVGSTQIMPFFVKNKGITRARVQFNLKDADGFSLDFKGKSGKFTDPAFPNIFFLELEKETSVECGIAFSPKEVATYNFRIQVRVNVFAASELDSQCRLSDSHVIPNRPPVIRPCHIQATVLQAPVTLSSTHFIFEIPLHSLDPNNRVTKTQNLVLHNTSRKDVVWNLDIRNTGKLFKDGIFKFSTLSGTLQPNEECNVAVNFCPKQPREYTADIPIYLNDNPVCYRMLHLVGEIKSPKLLFVPPFVFFTPVPLDVPAVMDVNILPQNYFRDSTLSVHLSPAKLLDGNEIQLLSVNFPKDRVIVGSSIGINAALTCRLSFKSSKPVSFFTKVLFCDSRNNWFSLPVSATAENCMLTIYSYMAIHLDEQKIIVKNEKDTSSVKAESKSLLASRKTGLPSTAPSKFSDAEPAKRRLFVGMEIIPEGLKSGKCEMPKKGNRSLKNEAKDKEFFSPKEGTRTYDFFLKTVNAAQTWFSLFGWPEGPHSLNIPETVRRDVYKIQVYSSALSARKFSRQSDFSKYNKTIYDVLIHLCGKMPPGINSSQSLPVDYPERVIQLHWQHSLLLDFLSAQGACISHVLPEFLLEPEDYKKWIEIRSSTTISAKFSHIPKGKHSVVIDMTDFEVWSKRSWTDVFLQIYKVLVLSRIVPYSINNLPPVYMQNSPKVNAYFASSNIYSDSERILLSWMNTNYENARHVIWKNCQKGVIPPERWIVNFDKDLLDGLVFATVLGAYCPFLIESHFINMYTQPKSSEQYLHNCLIVVNVLHEIGFDMDIQATDICDPNPILMLMFCVYMYERLPTYLPKKVVPFHCTLHDTVFREIQLKNPSVKSLVYSATIVGRDASDFSLSQAGNTVTISAKNQITITLKFTSRFLHPAEASLLLISRPKNGIGGTTMTFALKGEVLNFKAIATIKCKSPCYKWKEVTVKVKNPFQASGDFNVILVESLTFISLPSQLTEYEESVDVLNHRAAVNSSGCGVAEGSPQDPNALKTSTESNFIKEFFCSAHTLHLAAKGTSSLELFFLPFGMHTRYCVIILSNRKIGELIYILEGRGIIPLPSRFFPVDSSSPLEYSCSPEEVLTKDDPVLYLKCKLHQILDVDLKLPLTNEAKEKALTFAAQHQMSKIEYERRLITGTLESSSIRVAIALLGLTEIEMCMLFNVSKLKKPKSILYKAELSLPEHFDIPKTVFIPQVPETQVNESAEKTAADGSVPVPLRFVPLSPGRYPCKILLTSKYDVRLYCIEGVVNEERPEARFDFETPAFEALTQNIPINNETKNEWKFHVTVEGEWFHGPPILYVGPGETVDYPLTFKPIFECEIMGKLILQNEVDGMEHIFDIKGIGKRPLALEHIIIDCQVGEMTNKPIMVPNCTPSILTFKVSSDLPIVWGNPDITVDPDNTVPYILHVCPWKRGILKGTISFSVKSKHNGDSQDDSDEDQDTDQIPFYKKSLSELSDKFDDEKADNAINNFQIWYHLEIHSAPGPPLEIIDMKCAALESFYIEVPLFNPEEKIIHFDVLFSSAAFSGVDELDLFPLDSISCIIYYSPARTGFTEESIIFQPDLGLEFWYLLKITTDIPEATMMKEIYCDLGKVVTEMISLDNPTHETLELHATNSNTENFVLEIKRIPLIIPPNSTRDVPIHFRPSALGRASHQTSVIFHCAQFSEWIFLISGIGLFPQPHEIQKVTAYLHLQTCIPIPFQNPTKEDVFIDILLTGEEKPKRLVMAQIWDSFMEETSAFKISGVTHTKGIALPPKGTLDIQVLFMPQVMKLQKTMVLIQMRKASGKRWFIDNFMELHPEVKRGLGLDSEEILEIRWIYPIIGVPQTSPPESPQIVITCQARKRLEEEVEVLLDGDFLGENPILELSDFTVIPKRKSYAYYEDIEDKPMKREFEYGIEFESEDEEASLESCMALCLIKKSYNANNEQITLVFSLIFTPNKPVRSQVTLKVECMTDGIWTFPMMLIATEPDVDEVFDIEGIGLFKEATVDFRLTSQSRNPESYMAFFLPGSDPEFFVKPQIGELLPKGTLITVGFIPTMYSRKYKATLAIQTEDMYWLYEINGLPQISILPLKAKAKVDAHNEMFDKKPARRRNFLYENAQLTRTGVSSTIKGARLMLNNK", "length": 3158, "header": "tr|A0AAA9SCT4-1|A0AAA9SCT4_BOVIN Isoform 1 of Calponin-homology (CH) domain-containing protein OS=Bos taurus OX=9913 GN=CFAP47 PE=4 SV=1 CANONICAL=A0AAA9SCT4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4/entry#A0AAA9SCT4-1", "sequence": { "sequence": "METERSSLVARDLDTTKKDMKLRVTPSEMKFRNAVAGRVYRLPLTVQNLGRSSQKIHFQEPVKPQFKLILTNLDKSLASGLQTTAMVEYHPDKNEDICDQLLISIGNKTIEVPLIGLIPSCQLEIEPEVNFGTLVASSKVYCKEINIINHGSVPGIFKTEYQGQLSIVIFPTSGVVQPKSSVVIKVDFCADQPIVVNELAKVSLQDRPDVFLNIRAHVVEQIIELLNINNDKKLECISFGSVFFGTSKIERALLYNNSPEPINWVAIMQDDSVGEELGTNIKQRTDVALNNLTYLRKIKSIDITTIISCVPNEGRLLPYQKSLISFCFSPKLIIDVQKNDPSHRQDYAVFLRFESVASKDGFLRDDNQIIKSGSFQKIELALTGSGLPVLLQFDPGRILNFAPCFMGGHSEIHCVMQNRSKSLPLMYHFKKTAHFKIDPQKGKIDEGCIQNVTCSFIPHQVGVFKVKQFIEIIGSVADENLQSSSLKPFHHIYLYFNSVCKPSTKKVVMKVNPGISPLVSNPTGQFVVKDLVQYKDHARVAMLQSTMTRIHNHKINKELLKDALIAFPNDRAASIRSGEDHENFRTIFTKIPRYNYVDPDFAYTKFEKIVKKSHDNYYVEYIKFLRNVRLQKEAHRKHIYSYNDIDIGLHPASGLKSPTVSEVEREEELPSTQYWIKHNQLLRTRNIAVKETKSLRRKVLKGLKSDPSTPYEKHDCSLTLTPKQIYQVIVGPSVLNFGDVCVNSTNTHLLHIINMLPIHILMQLDVSLEELKKTSQFSYVIPPTTNTYISVIFESPTIGKFWKSFTFTVNNMPGGHILVMAVVLPVRLQLSSNELILRPRGFLVKTCFRGTVRMYNHQNYFVKFEWQPINTGKGMAFSIRPAKGTVEPYCSLECEVTWQPGFDSPERGEFILHVSEGNTLKLKCLAHLGHSKVTFLEPRILFSNSPQGLTTWRKAILHNVGQNHAYFKVCDQSLLSMIHIVPSQGIIPLGGLTVLNISCTPTVKEKFDIRTKVAIRCAKDIDLRIGGSVEVADIEIHPNKFNFIGTYVGSTQIMPFFVKNKGITRARVQFNLKDADGFSLDFKGKSGKFTDPAFPNIFFLELEKETSVECGIAFSPKEVATYNFRIQVRVNVFAASELDSQCRLSDSHVIPNRPPVIRPCHIQATVLQAPVTLSSTHFIFEIPLHSLDPNNRVTKTQNLVLHNTSRKDVVWNLDIRNTGKLFKDGIFKFSTLSGTLQPNEECNVAVNFCPKQPREYTADIPIYLNDNPVCYRMLHLVGEIKSPKLLFVPPFVFFTPVPLDVPAVMDVNILPQNYFRDSTLSVHLSPAKLLDGNEIQLLSVNFPKDRVIVGSSIGINAALTCRLSFKSSKPVSFFTKVLFCDSRNNWFSLPVSATAENCMLTIYSYMAIHLDEQKIIVKNEKDTSSVKAESKSLLASRKTGLPSTAPSKFSDAEPAKRRLFVGMEIIPEGLKSGKCEMPKKGNRSLKNEAKDKEFFSPKEGTRTYDFFLKTVNAAQTWFSLFGWPEGPHSLNIPETVRRDVYKIQVYSSALSARKFSRQSDFSKYNKTIYDVLIHLCGKMPPGINSSQSLPVDYPERVIQLHWQHSLLLDFLSAQGACISHVLPEFLLEPEDYKKWIEIRSSTTISAKFSHIPKGKHSVVIDMTDFEVWSKRSWTDVFLQIYKVLVLSRIVPYSINNLPPVYMQNSPKVNAYFASSNIYSDSERILLSWMNTNYENARHVIWKNCQKGVIPPERWIVNFDKDLLDGLVFATVLGAYCPFLIESHFINMYTQPKSSEQYLHNCLIVVNVLHEIGFDMDIQATDICDPNPILMLMFCVYMYERLPTYLPKKVVPFHCTLHDTVFREIQLKNPSVKSLVYSATIVGRDASDFSLSQAGNTVTISAKNQITITLKFTSRFLHPAEASLLLISRPKNGIGGTTMTFALKGEVLNFKAIATIKCKSPCYKWKEVTVKVKNPFQASGDFNVILVESLTFISLPSQLTEYEESVDVLNHRAAVNSSGCGVAEGSPQDPNALKTSTESNFIKEFFCSAHTLHLAAKGTSSLELFFLPFGMHTRYCVIILSNRKIGELIYILEGRGIIPLPSRFFPVDSSSPLEYSCSPEEVLTKDDPVLYLKCKLHQILDVDLKLPLTNEAKEKALTFAAQHQMSKIEYERRLITGTLESSSIRVAIALLGLTEIEMCMLFNVSKLKKPKSILYKAELSLPEHFDIPKTVFIPQVPETQVNESAEKTAADGSVPVPLRFVPLSPGRYPCKILLTSKYDVRLYCIEGVVNEERPEARFDFETPAFEALTQNIPINNETKNEWKFHVTVEGEWFHGPPILYVGPGETVDYPLTFKPIFECEIMGKLILQNEVDGMEHIFDIKGIGKRPLALEHIIIDCQVGEMTNKPIMVPNCTPSILTFKVSSDLPIVWGNPDITVDPDNTVPYILHVCPWKRGILKGTISFSVKSKHNGDSQDDSDEDQDTDQIPFYKKSLSELSDKFDDEKADNAINNFQIWYHLEIHSAPGPPLEIIDMKCAALESFYIEVPLFNPEEKIIHFDVLFSSAAFSGVDELDLFPLDSISCIIYYSPARTGFTEESIIFQPDLGLEFWYLLKITTDIPEATMMKEIYCDLGKVVTEMISLDNPTHETLELHATNSNTENFVLEIKRIPLIIPPNSTRDVPIHFRPSALGRASHQTSVIFHCAQFSEWIFLISGIGLFPQPHEIQKVTAYLHLQTCIPIPFQNPTKEDVFIDILLTGEEKPKRLVMAQIWDSFMEETSAFKISGVTHTKGIALPPKGTLDIQVLFMPQVMKLQKTMVLIQMRKASGKRWFIDNFMELHPEVKRGLGLDSEEILEIRWIYPIIGVPQTSPPESPQIVITCQARKRLEEEVEVLLDGDFLGENPILELSDFTVIPKRKSYAYYEDIEDKPMKREFEYGIEFESEDEEASLESCMALCLIKKSYNANNEQITLVFSLIFTPNKPVRSQVTLKVECMTDGIWTFPMMLIATEPDVDEVFDIEGIGLFKEATVDFRLTSQSRNPESYMAFFLPGSDPEFFVKPQIGELLPKGTLITVGFIPTMYSRKYKATLAIQTEDMYWLYEINGLPQISILPLKAKAKVDAHNEMFDKKPARRRNFLYENAQLTRTGVSSTIKGARLMLNNK", "length": 3158, "header": "tr|A0AAA9SCT4-1|A0AAA9SCT4_BOVIN Isoform 1 of Calponin-homology (CH) domain-containing protein OS=Bos taurus OX=9913 GN=CFAP47 PE=4 SV=1 CANONICAL=A0AAA9SCT4-1" }, "locus": { "chromosome": "X", "start_pos": 107332154, "end_pos": 106829623, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123024.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123024.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081330.1" } ] } }, { "isoform_ac": "A0AAA9SV39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4/entry#A0AAA9SV39-1", "sequence": { "sequence": "METERSSLVARDLDTTKKDMKLRVTPSEMKFRNAVAGRVYRLPLTVQNLGRSSQKIHFQEPVKPQFKLILTNLDKSLASGLQTTAMVEYHPDKNEDICDQLLISIGNKTIEVPLIGLIPSCQLEIEPEVNFGTLVASSKVYCKEINIINHGSVPGIFKTEYQGQLSIVIFPTSGVVQPKSSVVIKVDFCADQPIVVNELAKVSLQDRPDVFLNIRAHVVEQIIELLNINNDKKLECISFGSVFFGTSKIERALLYNNSPEPINWVAIMQDDSVGEELGTNIKQRTDVALNNLTYLRKIKSIDITTIISCVPNEGRLLPYQKSLISFCFSPKLIIDVQKNDPSHRQDYAVFLRFESVASKDGFLRDDNQIIKSGSFQKIELALTGSGLPVLLQFDPGRILNFAPCFMGGHSEIHCVMQNRSKSLPLMYHFKKTAHFKIDPQKGKIDEGCIQNVTCSFIPHQVGVFKVKQFIEIIGSVADENLQSSSLKPFHHIYLYFNSVCKPSTKKVVMKVNPGISPLVSNPTGQFVVKDLVQYKDHARVAMLQSTMTRIHNHKINKELLKDALIAFPNDRAASIRSGEDHENFRTIFTKIPRYNYVDPDFAYTKFEKIVKKSHDNYYVEYIKFLRNVRLQKEAHRKHIYSYNDIDIGLHPASGLKSPTVSEVEREEELPSTQYWIKHNQLLRTRNIAVKETKSLRRKVLKGLKSDPSTPYEKHDCSLTLTPKQIYQVIVGPSVLNFGDVCVNSTNTHLLHIINMLPIHILMQLDVSLEELKKTSQFSYVIPPTTNTYISVIFESPTIGKFWKSFTFTVNNMPGGHILVMAVVLPVRLQLSSNELILRPRGFLVKTCFRGTVRMYNHQNYFVKFEWQPINTGKGMAFSIRPAKGTVEPYCSLECEVTWQPGFDSPERGEFILHVSEGNTLKLKCLAHVDFYFEGSKLVYAYVY", "length": 943, "header": "tr|A0AAA9SV39-1|A0AAA9SV39_BOVIN Computationally mapped isoform of Cilia and flagella associated protein 47 OS=Bos taurus OX=9913 GN=CFAP47 PE=4 SV=1 CANONICAL=A0AAA9SCT4-1" }, "locus": { "chromosome": "X", "start_pos": 107332154, "end_pos": 107275770, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122392.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122392.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087050.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 172, "start_aa": "Thr", "end_pos": 172, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr172", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1203, "end_pos": 1205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1482, "end_pos": 1484, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1565, "end_pos": 1567, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1584, "end_pos": 1586, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2015, "end_pos": 2017, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2202, "end_pos": 2204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2241, "end_pos": 2243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2315, "end_pos": 2317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2410, "end_pos": 2412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2673, "end_pos": 2675, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 743, "end_pos": 745, "annotation": "n_glycosylation_sequon" }, { "start_pos": 996, "end_pos": 998, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT4" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 1719, "end_pos": 1842, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 172 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 1203, "end_pos": 1205 }, { "start_pos": 1482, "end_pos": 1484 }, { "start_pos": 1565, "end_pos": 1567 }, { "start_pos": 1584, "end_pos": 1586 }, { "start_pos": 2015, "end_pos": 2017 }, { "start_pos": 2202, "end_pos": 2204 }, { "start_pos": 2241, "end_pos": 2243 }, { "start_pos": 2315, "end_pos": 2317 }, { "start_pos": 2410, "end_pos": 2412 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 2673, "end_pos": 2675 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 743, "end_pos": 745 }, { "start_pos": 996, "end_pos": 998 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCY6-1", "uniprot_ac": "A0AAA9SCY6", "uniprot_id": "A0AAA9SCY6_BOVIN", "mass": { "chemical_mass": 14417.0, "monoisotopic_mass": 14417.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Small ribosomal subunit protein uS8", "type": "recommended", "evidence": [ { "id": "A0AAA9SCY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S15a", "type": "synonym", "evidence": [ { "id": "A0AAA9SCY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SCY6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCY6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11758", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11758", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWPMLSRVSTMPKREANGQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIILTTSAGIMDHEEARRKHTGGKILGFFF", "length": 126, "header": "tr|A0AAA9SCY6-1|A0AAA9SCY6_BOVIN Isoform 1 of Small ribosomal subunit protein uS8 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SCY6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6/entry#A0AAA9SCY6-1", "sequence": { "sequence": "MSWPMLSRVSTMPKREANGQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIILTTSAGIMDHEEARRKHTGGKILGFFF", "length": 126, "header": "tr|A0AAA9SCY6-1|A0AAA9SCY6_BOVIN Isoform 1 of Small ribosomal subunit protein uS8 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SCY6-1" }, "locus": { "chromosome": "11", "start_pos": 73538445, "end_pos": 73538068, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105351.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105351.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080170.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080170.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD06-1", "uniprot_ac": "A0AAA9SD06", "uniprot_id": "A0AAA9SD06_BOVIN", "mass": { "chemical_mass": 58707.0, "monoisotopic_mass": 58707.0 }, "refseq": {}, "gene_names": [ { "name": "PRCP", "type": "recommended", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ] } ], "protein_names": [ { "name": "Lysosomal Pro-X carboxypeptidase", "type": "recommended", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#names_and_taxonomy" } ] }, { "name": "3.4.16.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#names_and_taxonomy" } ] }, { "name": "Proline carboxypeptidase", "type": "synonym", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#names_and_taxonomy" } ] }, { "name": "Prolylcarboxypeptidase", "type": "synonym", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06#function" }, { "database": "UniProtKB", "id": "ARBA00059701", "url": "https://www.uniprot.org/uniprotkb/ARBA00059701#function" }, { "database": "UniProtKB", "id": "F1MAU4", "url": "https://www.uniprot.org/uniprotkb/F1MAU4#function" }, { "database": "UniProtKB", "id": "A0AAA9T5G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G5#function" }, { "database": "UniProtKB", "id": "A0AAA9T8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRCP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06", "locus": { "chromosome": "29", "start_pos": 12830962, "end_pos": 12744752, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033731", "url": "https://www.ensembl.org/id/ENSBTAG00000033731" } ] } } ], "crossref": [ { "id": "A0AAA9SD06", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD06", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033731", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033731", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MAU4", "url": "https://www.orthodb.org/?gene=F1MAU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11010", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11010", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11010:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11010:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05577", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05577", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9970672", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9970672", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAU4", "url": "https://www.uniprot.org/uniprotkb/F1MAU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAU4-1", "url": "https://www.uniprot.org/uniprotkb/F1MAU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRCSLLLLLLLIAFLTPGAANPVSPSLRAPSSLPWSTSFRSRPTITLKYSIRYIQQKMDSSPLSHQRSPKLKCFHVDHFGFNIDRTFKQRYLIADNYWKEDGGSILFYTGNEGDIIWFCNNTGFMWDIAEEMKAMLVFAEHRYYGESLPFGADSFSDSRHLNFLTTEQALADFAKLIRYLKRTIPGARNQPVIALGGSYGGMLAAWFRMKYPHLVVGALASSAPIWQFNDLVPCDIFMKIVTTDFSQSGPNCSESIRRSWDAINRLAKKGPGLRWLSEALHLCTPLTKSQDVQRLKDWISETWVNVAMVDYPYESNFLQPLPAWPVKVVCQYFKYSNVPDTVMVQNIFQALNVYYNYSGQAKCLNVSETATSSLGVLGWSYQACTEMVMPTCSDGVDDMFEPHSWNMKEYSDDCFKQWGVRPRPSWIPTMYGGKNISSHTNIIFSNGELDPWSGGGVTKDITDTLLAIVIPNGAHHLDLRASNALDPVSVQLTRSLEVKYMKQWISDFYVRLRKMN", "length": 517, "header": "tr|A0AAA9SD06-1|A0AAA9SD06_BOVIN Isoform 1 of Lysosomal Pro-X carboxypeptidase OS=Bos taurus OX=9913 GN=PRCP PE=3 SV=1 CANONICAL=A0AAA9SD06-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#A0AAA9SD06-1", "sequence": { "sequence": "MGRCSLLLLLLLIAFLTPGAANPVSPSLRAPSSLPWSTSFRSRPTITLKYSIRYIQQKMDSSPLSHQRSPKLKCFHVDHFGFNIDRTFKQRYLIADNYWKEDGGSILFYTGNEGDIIWFCNNTGFMWDIAEEMKAMLVFAEHRYYGESLPFGADSFSDSRHLNFLTTEQALADFAKLIRYLKRTIPGARNQPVIALGGSYGGMLAAWFRMKYPHLVVGALASSAPIWQFNDLVPCDIFMKIVTTDFSQSGPNCSESIRRSWDAINRLAKKGPGLRWLSEALHLCTPLTKSQDVQRLKDWISETWVNVAMVDYPYESNFLQPLPAWPVKVVCQYFKYSNVPDTVMVQNIFQALNVYYNYSGQAKCLNVSETATSSLGVLGWSYQACTEMVMPTCSDGVDDMFEPHSWNMKEYSDDCFKQWGVRPRPSWIPTMYGGKNISSHTNIIFSNGELDPWSGGGVTKDITDTLLAIVIPNGAHHLDLRASNALDPVSVQLTRSLEVKYMKQWISDFYVRLRKMN", "length": 517, "header": "tr|A0AAA9SD06-1|A0AAA9SD06_BOVIN Isoform 1 of Lysosomal Pro-X carboxypeptidase OS=Bos taurus OX=9913 GN=PRCP PE=3 SV=1 CANONICAL=A0AAA9SD06-1" }, "locus": { "chromosome": "29", "start_pos": 12830256, "end_pos": 12746382, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087758.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087758.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081742.1" } ] } }, { "isoform_ac": "A0AAA9T5G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#A0AAA9T5G5-1", "sequence": { "sequence": "TGVDHFGFNIDRTFKQRYLIADNYWKEDGGSILFYTGNEGDIIWFCNNTGFMWDIAEEMKAMLVFAEHRYYGESLPFGADSFSDSRHLNFLTTEQALADFAKLIRYLKRTIPGARNQPVIALGGSYGGMLAAWFRMKYPHLVVGALASSAPIWQFNDLVPCDIFMKIVTTDFSQSGPNCSESIRRSWDAINRLAKKGPGLRWLSEALHLCTPLTKSQDVQRLKDWISETWVNVAMVDYPYESNFLQPLPAWPVKVVCQYFKYSNVPDTVMVQNIFQALNVYYNYSGQAKCLNVSETATSSLGVLGWSYQACTEMVMPTCSDGVDDMFEPHSWNMKEYSDDCFKQWGVRPRPSWIPTMYGGKNISSHTNIIFSNGELDPWSGGGVTKDITDTLLAIVIPNGAHHLDLRASNALDPVSVQLTRSLEVKYMKQWISDFYVRLRKMN", "length": 443, "header": "tr|A0AAA9T5G5-1|A0AAA9T5G5_BOVIN Computationally mapped isoform of Lysosomal Pro-X carboxypeptidase OS=Bos taurus OX=9913 GN=PRCP PE=3 SV=1 CANONICAL=A0AAA9SD06-1" }, "locus": { "chromosome": "29", "start_pos": 12830256, "end_pos": 12745929, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134764.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134764.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091969.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091969.1" } ] } }, { "isoform_ac": "A0AAA9T8C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#A0AAA9T8C5-1", "sequence": { "sequence": "MDIIIIYLPHTNCLFYLMVDHFGFNIDRTFKQRYLIADNYWKEDGGSILFYTGNEGDIIWFCNNTGFMWDIAEEMKAMLVFAEHRYYGESLPFGADSFSDSRHLNFLTTEQALADFAKLIRYLKRTIPGARNQPVIALGGSYGGMLAAWFRMKYPHLVVGALASSAPIWQFNDLVPCDIFMKIVTTDFSQSGPNCSESIRRSWDAINRLAKKGPGLRWLSEALHLCTPLTKSQDVQRLKDWISETWVNVAMVDYPYESNFLQPLPAWPVKVVCQYFKYSNVPDTVMVQNIFQALNVYYNYSGQAKCLNVSETATSSLGVLGWSYQACTEMVMPTCSDGVDDMFEPHSWNMKEYSDDCFKQWGVRPRPSWIPTMYGGKNISSHTNIIFSNGELDPWSGGGVTKDITDTLLAIVIPNGAHHLDLRASNALDPVSVQLTRSLEVKYMKQWISDFYVRLRKMN", "length": 459, "header": "tr|A0AAA9T8C5-1|A0AAA9T8C5_BOVIN Computationally mapped isoform of Lysosomal Pro-X carboxypeptidase OS=Bos taurus OX=9913 GN=PRCP PE=3 SV=1 CANONICAL=A0AAA9SD06-1" }, "locus": { "chromosome": "29", "start_pos": 12830256, "end_pos": 12783835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100653.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100653.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092104.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092104.1" } ] } }, { "isoform_ac": "A0AAA9TQI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#A0AAA9TQI1-1", "sequence": { "sequence": "MGRCSLLLLLLLIAFLTPGAANPVSPSLRAPSSLPWSTSFRSRPTITLKYSIRYIQQKVDHFGFNIDRTFKQRYLIADNYWKEDGGSILFYTGNEGDIIWFCNNTVVCQYFKYSNVPDTVMVQNIFQALNVYYNYSGQAKCLNVSETATSSLGVLGWSYQACTEMVMPTCSDGVDDMFEPHSWNMKEYSDDCFKQWGVRPRPSWIPTMYGGKNISSHTNIIFSNGELDPWSGGGVTKDITDTLLAIVIPNGAHHLDLRASNALDPVSVQLTRSLEVKYMKQWISDFYVRLRKMN", "length": 294, "header": "tr|A0AAA9TQI1-1|A0AAA9TQI1_BOVIN Computationally mapped isoform of Prolylcarboxypeptidase OS=Bos taurus OX=9913 GN=PRCP PE=3 SV=1 CANONICAL=A0AAA9SD06-1" }, "locus": { "chromosome": "29", "start_pos": 12830256, "end_pos": 12746382, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111702.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111702.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100628.1" } ] } }, { "isoform_ac": "F1MAU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06/entry#F1MAU4-1", "sequence": { "sequence": "MGRCSLLLLLLLIAFLTPGAANPVSPSLRAPSSLPWSTSFRSRPTITLKYSIRYIQQKVDHFGFNIDRTFKQRYLIADNYWKEDGGSILFYTGNEGDIIWFCNNTGFMWDIAEEMKAMLVFAEHRYYGESLPFGADSFSDSRHLNFLTTEQALADFAKLIRYLKRTIPGARNQPVIALGGSYGGMLAAWFRMKYPHLVVGALASSAPIWQFNDLVPCDIFMKIVTTDFSQSGPNCSESIRRSWDAINRLAKKGPGLRWLSEALHLCTPLTKSQDVQRLKDWISETWVNVAMVDYPYESNFLQPLPAWPVKVVCQYFKYSNVPDTVMVQNIFQALNVYYNYSGQAKCLNVSETATSSLGVLGWSYQACTEMVMPTCSDGVDDMFEPHSWNMKEYSDDCFKQWGVRPRPSWIPTINGELDPWSGGGVTKDITDTLLAIVIPNGAHHLDLRASNALDPVSVQLTRSLEVKYMKQWISDFYVRLRKMN", "length": 484, "header": "tr|F1MAU4-1|F1MAU4_BOVIN Computationally mapped isoform of Lysosomal Pro-X carboxypeptidase OS=Bos taurus OX=9913 GN=PRCP PE=3 SV=2 CANONICAL=A0AAA9SD06-1" }, "locus": { "chromosome": "29", "start_pos": 12830256, "end_pos": 12746382, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047906.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047906.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045060.2", "url": "https://www.ensembl.org/id/ENSBTAP00000045060.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-9970672", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9970672", "resource": "Reactome", "description": "FXIIa activates plasma kallikrein-kinin system" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "basal part of cell", "id": "GO:0045178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "angiotensin maturation", "id": "GO:0002003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002003", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "regulation of blood vessel endothelial cell migration", "id": "GO:0043535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043535", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "negative regulation of systemic arterial blood pressure", "id": "GO:0003085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "angiogenesis involved in wound healing", "id": "GO:0060055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "serine-type carboxypeptidase activity", "id": "GO:0004185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004185", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "metallocarboxypeptidase activity", "id": "GO:0004181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "serine-type exopeptidase activity", "id": "GO:0070008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" }, { "name": "dipeptidyl-peptidase activity", "id": "GO:0008239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008239", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, azurophil granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08037-1", "Q9MYM4-1", "Q9XT97-1", "A0A3Q1MGR4-1", "F1MXY2-1", "P61223-1", "A0AAA9SD06-1", "A0A3Q1LM90-1", "A6H730-1", "A0A140T891-1", "A0A3S5ZPJ9-1" ], "evidence": [ { "id": "R-BTA-6798739", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798739" } ] }, { "id": "R-BTA-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, ficolin-1-rich granule membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61585-1", "Q9MYM4-1", "A2VDP5-1", "A0AAA9SD06-1" ], "evidence": [ { "id": "R-BTA-6800426", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6800426" } ] }, { "id": "R-BTA-9857945", "name": "prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJ63-1", "A0AAA9SD06-1" ], "evidence": [ { "id": "R-BTA-9857945", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9857945" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T891", "gene_name": "VNN1", "activity": [ { "ec_number": "3.5.1.92", "activity": "(R)-pantetheine + H2O = cysteamine + (R)-pantothenate.", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] }, { "ec_number": "3.5.1.92", "activity": "", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] } ] }, { "uniprot_ac": "A0A3Q1LM90", "gene_name": "ATP11B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3S5ZPJ9", "gene_name": "MANBA", "activity": [ { "ec_number": "3.2.1.25", "activity": "Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.", "evidence": [ { "id": "A0A3S5ZPJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPJ9" } ] }, { "ec_number": "3.2.1.25", "activity": "", "evidence": [ { "id": "A0A3S5ZPJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPJ9" } ] } ] }, { "uniprot_ac": "A0AAA9SD06", "gene_name": "PRCP", "activity": [ { "ec_number": "3.4.16.2", "activity": "Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ] }, { "ec_number": "3.4.16.2", "activity": "", "evidence": [ { "id": "A0AAA9SD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD06" } ] } ] }, { "uniprot_ac": "A2VDP5", "gene_name": "ENPP4", "activity": [ { "ec_number": "3.6.1.29", "activity": "P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+).", "evidence": [ { "id": "A2VDP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDP5" } ] }, { "ec_number": "3.6.1.29", "activity": "", "evidence": [ { "id": "A2VDP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDP5" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "F1MXY2", "gene_name": "MGST1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "F1MXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXY2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "F1MXY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXY2" } ] } ] }, { "uniprot_ac": "P08037", "gene_name": "B4GALT1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "P08037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08037" } ] }, { "ec_number": "2.4.1.275", "activity": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + UDP + H(+).", "evidence": [ { "id": "P08037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08037" } ] }, { "ec_number": "2.4.1.22", "activity": "D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+).", "evidence": [ { "id": "P08037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08037" } ] }, { "ec_number": "2.4.1.38", "activity": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+).", "evidence": [ { "id": "P08037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08037" } ] }, { "ec_number": "2.4.1.90", "activity": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + UDP + H(+).", "evidence": [ { "id": "P08037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08037" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "Q2KJ63", "gene_name": "KLKB1", "activity": [ { "ec_number": "3.4.21.34", "activity": "Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.", "evidence": [ { "id": "Q2KJ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ63" } ] }, { "ec_number": "3.4.21.34", "activity": "", "evidence": [ { "id": "Q2KJ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ63" } ] } ] }, { "uniprot_ac": "Q9MYM4", "gene_name": "GAA", "activity": [ { "ec_number": "3.2.1.20", "activity": "Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.", "evidence": [ { "id": "Q9MYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYM4" } ] }, { "ec_number": "3.2.1.20", "activity": "", "evidence": [ { "id": "Q9MYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYM4" } ] } ] }, { "uniprot_ac": "Q9XT97", "gene_name": "PSEN1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q9XT97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XT97" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.16.2", "ec_name": "Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.", "evidence": [ { "id": "3.4.16.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.16.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 436, "end_pos": 438 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD31-1", "uniprot_ac": "A0AAA9SD31", "uniprot_id": "A0AAA9SD31_BOVIN", "mass": { "chemical_mass": 14620.0, "monoisotopic_mass": 14620.0 }, "refseq": { "ac": "XP_002687447", "name": "chemokine-like protein TAFA-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687447" }, "gene_names": [ { "name": "TAFA2", "type": "recommended", "evidence": [ { "id": "A0AAA9SD31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ] }, { "name": "TAFA2", "type": "synonym", "evidence": [ { "id": "XP_002687447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687447" } ] } ], "protein_names": [ { "name": "TAFA chemokine like family member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SD31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31/entry#names_and_taxonomy" } ] }, { "name": "chemokine-like protein TAFA-2", "type": "synonym", "evidence": [ { "id": "XP_002687447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687447" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAFA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31", "locus": { "chromosome": "5", "start_pos": 51924551, "end_pos": 51361979, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047818", "url": "https://www.ensembl.org/id/ENSBTAG00000047818" } ] } } ], "crossref": [ { "id": "A0AAA9SD31", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD31", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047818", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047818", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100297656", "url": "https://www.ncbi.nlm.nih.gov/gene/100297656", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100297656", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297656", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31770", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31770", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31770:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31770:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687447", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687447", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2Q2", "url": "https://www.uniprot.org/uniprotkb/G3N2Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2Q2-1", "url": "https://www.uniprot.org/uniprotkb/G3N2Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKAHHVKTGTCEVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCLEGEECKVLPDRKGWSCSSGNKVKTTRVTH", "length": 131, "header": "tr|A0AAA9SD31-1|A0AAA9SD31_BOVIN Isoform 1 of TAFA chemokine like family member 2 OS=Bos taurus OX=9913 GN=TAFA2 PE=3 SV=1 CANONICAL=A0AAA9SD31-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31/entry#A0AAA9SD31-1", "sequence": { "sequence": "MSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKAHHVKTGTCEVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCLEGEECKVLPDRKGWSCSSGNKVKTTRVTH", "length": 131, "header": "tr|A0AAA9SD31-1|A0AAA9SD31_BOVIN Isoform 1 of TAFA chemokine like family member 2 OS=Bos taurus OX=9913 GN=TAFA2 PE=3 SV=1 CANONICAL=A0AAA9SD31-1" }, "locus": { "chromosome": "5", "start_pos": 51923519, "end_pos": 51752668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128085.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128085.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084031.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084031.1" } ] } }, { "isoform_ac": "A0AAA9SNP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31/entry#A0AAA9SNP9-1", "sequence": { "sequence": "MTEVPREDLDESRERMSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKAHHVKTGTCEVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCLEGEECKVLPDRKGWSCSSGNKVKTTRVTH", "length": 146, "header": "tr|A0AAA9SNP9-1|A0AAA9SNP9_BOVIN Computationally mapped isoform of TAFA chemokine like family member 2 OS=Bos taurus OX=9913 GN=TAFA2 PE=3 SV=1 CANONICAL=A0AAA9SD31-1" }, "locus": { "chromosome": "5", "start_pos": 51923519, "end_pos": 51690007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135788.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135788.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085522.1" } ] } }, { "isoform_ac": "A0AAA9SNW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31/entry#A0AAA9SNW5-1", "sequence": { "sequence": "MSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKGNPLTKVKSSDPQG", "length": 49, "header": "tr|A0AAA9SNW5-1|A0AAA9SNW5_BOVIN Computationally mapped isoform of TAFA chemokine like family member 2 OS=Bos taurus OX=9913 GN=TAFA2 PE=4 SV=1 CANONICAL=A0AAA9SD31-1" }, "locus": { "chromosome": "5", "start_pos": 51923551, "end_pos": 51752668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093699.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093699.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085638.1" } ] } }, { "isoform_ac": "G3N2Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31/entry#G3N2Q2-1", "sequence": { "sequence": "MLQGFKTTFCVWNEELCLLLKEFQASVIRMSKRYLQKATKGKLLIIIFIVTLWGKVVSSANHHKAHHVKTGTCEVVALHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAAPSCVDASIVEQKWWCHMQPCLEGEECKVLPDRKGWSCSSGNKVKTTRVTH", "length": 160, "header": "tr|G3N2Q2-1|G3N2Q2_BOVIN Computationally mapped isoform of TAFA chemokine like family member 2 OS=Bos taurus OX=9913 GN=TAFA2 PE=3 SV=3 CANONICAL=A0AAA9SD31-1" }, "locus": { "chromosome": "5", "start_pos": 51923519, "end_pos": 51419384, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064116.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064116.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056170.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056170.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297656", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297656", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "pmid": "" }, { "name": "visual learning", "id": "GO:0008542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD51-1", "uniprot_ac": "A0AAA9SD51", "uniprot_id": "A0AAA9SD51_BOVIN", "mass": { "chemical_mass": 8890.0, "monoisotopic_mass": 8890.0 }, "refseq": { "ac": "NP_001239439", "name": "uncharacterized protein C14orf132 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239439" }, "gene_names": [ { "name": "C21H14orf132", "type": "recommended", "evidence": [ { "id": "A0AAA9SD51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51" } ] }, { "name": "C14orf132", "type": "synonym", "evidence": [ { "id": "NP_001239439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239439" } ] }, { "name": "C21H14orf132", "type": "synonym", "evidence": [ { "id": "NP_001239439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239439" } ] } ], "protein_names": [ { "name": "Chromosome 21 C14orf132 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SD51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C14orf132 homolog", "type": "synonym", "evidence": [ { "id": "NP_001239439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239439" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C21H14orf132", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51", "locus": {} } ], "crossref": [ { "id": "A0AAA9SD51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD51", "database": "AlphaFoldDB", "categories": [] }, { "id": "617871", "url": "https://www.ncbi.nlm.nih.gov/gene/617871", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR059849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617871", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617871", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PF28562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001239439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLSFMAAQLPMMGGAFMDSPNEDFSTEYSLFNSSTNVHAASNGQGQPEEPPRSSNDAVLLWIAIIATLGNIVVVGVVYAFTF", "length": 83, "header": "tr|A0AAA9SD51-1|A0AAA9SD51_BOVIN Isoform 1 of Chromosome 21 C14orf132 homolog OS=Bos taurus OX=9913 GN=C21H14orf132 PE=4 SV=2 CANONICAL=A0AAA9SD51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD51/entry#A0AAA9SD51-1", "sequence": { "sequence": "MDLSFMAAQLPMMGGAFMDSPNEDFSTEYSLFNSSTNVHAASNGQGQPEEPPRSSNDAVLLWIAIIATLGNIVVVGVVYAFTF", "length": 83, "header": "tr|A0AAA9SD51-1|A0AAA9SD51_BOVIN Isoform 1 of Chromosome 21 C14orf132 homolog OS=Bos taurus OX=9913 GN=C21H14orf132 PE=4 SV=2 CANONICAL=A0AAA9SD51-1" }, "locus": { "chromosome": "21", "start_pos": 60938569, "end_pos": 60892012, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081460.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081460.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617871", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617871", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD61-1", "uniprot_ac": "A0AAA9SD61", "uniprot_id": "A0AAA9SD61_BOVIN", "mass": { "chemical_mass": 12367.0, "monoisotopic_mass": 12367.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SD61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61", "locus": {} } ], "crossref": [ { "id": "A0AAA9SD61", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD61", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SD61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQSVTQPDDHIAVSEGARLELKCNYSSSVSPYLFWYMQYPNQGLQLLLKYVSGDNLVSGIKGFEAEFRNSETSFHLRKIPAHWKDSAKYFCALSDTVPGTAGGAEHKPPGTL", "length": 112, "header": "tr|A0AAA9SD61-1|A0AAA9SD61_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SD61-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61/entry#A0AAA9SD61-1", "sequence": { "sequence": "AQSVTQPDDHIAVSEGARLELKCNYSSSVSPYLFWYMQYPNQGLQLLLKYVSGDNLVSGIKGFEAEFRNSETSFHLRKIPAHWKDSAKYFCALSDTVPGTAGGAEHKPPGTL", "length": 112, "header": "tr|A0AAA9SD61-1|A0AAA9SD61_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SD61-1" }, "locus": { "chromosome": "10", "start_pos": 25266905, "end_pos": 25266570, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083345.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD61" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 95, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD62-1", "uniprot_ac": "A0AAA9SD62", "uniprot_id": "A0AAA9SD62_BOVIN", "mass": { "chemical_mass": 60517.0, "monoisotopic_mass": 60517.0 }, "refseq": {}, "gene_names": [ { "name": "STAM", "type": "recommended", "evidence": [ { "id": "A0AAA9SD62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ] } ], "protein_names": [ { "name": "Signal transducing adaptor molecule", "type": "synonym", "evidence": [ { "id": "A0AAA9SD62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62#function" }, { "database": "UniProtKB", "id": "ARBA00043869", "url": "https://www.uniprot.org/uniprotkb/ARBA00043869#function" }, { "database": "UniProtKB", "id": "A0AAA9SRL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL7#function" }, { "database": "UniProtKB", "id": "A0A3Q1LUU3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STAM", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62", "locus": { "chromosome": "13", "start_pos": 32172158, "end_pos": 32099368, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002658", "url": "https://www.ensembl.org/id/ENSBTAG00000002658" } ] } } ], "crossref": [ { "id": "A0AAA9SD62", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD62", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002658", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002658", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11964", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11964", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17000", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17000", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21389", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21389", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUU3", "url": "https://www.orthodb.org/?gene=A0A3Q1LUU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45929", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45929", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45929:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45929:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00790", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00790", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02809", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02809", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LUU3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTAANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSNLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGMGLFPSNFVTADLTVEPEMIKTEKKTVQFSDEVQVETIEPEPEPAYIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQQYYIQSSGVSGSQVYPPQSGAYLVAGSAQMSHLQSYSLPPEQLSSLSQGAVPPSANPALPTQQAQASYPSTMVSSVPGSTYPSQASVYSPPPAATAAPDVTIYQNTGTSLSQDSLKDWYSVQFSHSVLSDSLQPHESQHTRPPCPSPIPGVHSNSCPLSQ", "length": 550, "header": "tr|A0AAA9SD62-1|A0AAA9SD62_BOVIN Isoform 1 of Signal transducing adaptor molecule OS=Bos taurus OX=9913 GN=STAM PE=3 SV=1 CANONICAL=A0AAA9SD62-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62/entry#A0A3Q1LUU3-1", "sequence": { "sequence": "MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTAANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSNLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGMGLFPSNFVTADLTVEPEMIKTEKKTVQFSDEVQVETIEPEPEPAYIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQQYYIQSSGVSGSQVYPPQSGAYLVAGSAQMSHLQSYSLPPEQLSSLSQGAVPPSANPALPTQQAQASYPSTMVSSVPGSTYPSQASVYSPPPAATAAPDVTIYQNTGTSLSQAMVKLNSSVLFHC", "length": 515, "header": "tr|A0A3Q1LUU3-1|A0A3Q1LUU3_BOVIN Computationally mapped isoform of Signal transducing adaptor molecule OS=Bos taurus OX=9913 GN=STAM PE=3 SV=2 CANONICAL=A0AAA9SD62-1" }, "locus": { "chromosome": "13", "start_pos": 32154961, "end_pos": 32099509, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084276.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084276.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064330.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064330.2" } ] } }, { "isoform_ac": "A0AAA9SD62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62/entry#A0AAA9SD62-1", "sequence": { "sequence": "MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTAANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSNLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGMGLFPSNFVTADLTVEPEMIKTEKKTVQFSDEVQVETIEPEPEPAYIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQQYYIQSSGVSGSQVYPPQSGAYLVAGSAQMSHLQSYSLPPEQLSSLSQGAVPPSANPALPTQQAQASYPSTMVSSVPGSTYPSQASVYSPPPAATAAPDVTIYQNTGTSLSQDSLKDWYSVQFSHSVLSDSLQPHESQHTRPPCPSPIPGVHSNSCPLSQ", "length": 550, "header": "tr|A0AAA9SD62-1|A0AAA9SD62_BOVIN Isoform 1 of Signal transducing adaptor molecule OS=Bos taurus OX=9913 GN=STAM PE=3 SV=1 CANONICAL=A0AAA9SD62-1" }, "locus": { "chromosome": "13", "start_pos": 32171154, "end_pos": 32099509, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088673.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088673.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081475.1" } ] } }, { "isoform_ac": "A0AAA9SRL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62/entry#A0AAA9SRL7-1", "sequence": { "sequence": "MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTAANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSNLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGMGLFPSNFVTADLTVEPEMIKTEKKTVQFSDEVQVETIEPEPEPAYIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQQYYIQSSGVSGSQVYPPQSGAYLVAGSAQMSHLQSYSLPPEQLSSLSQGAVPPSANPALPTQQAQASYPSTMVSSVPGSTYPSQASVYSPPPAATAAPDVTIYQNTGTSLSQVPNYTLPSTLPQPGGSQQPPQPQQPYSQKALL", "length": 502, "header": "tr|A0AAA9SRL7-1|A0AAA9SRL7_BOVIN Computationally mapped isoform of Signal transducing adaptor molecule OS=Bos taurus OX=9913 GN=STAM PE=3 SV=1 CANONICAL=A0AAA9SD62-1" }, "locus": { "chromosome": "13", "start_pos": 32153936, "end_pos": 32099509, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086707.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "multivesicular body assembly", "id": "GO:0036258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036258", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "positive regulation of exosomal secretion", "id": "GO:1903543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "regulation of extracellular exosome assembly", "id": "GO:1903551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903551", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ESCRT-0 complex", "id": "GO:0033565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" }, { "name": "ubiquitin-like protein ligase binding", "id": "GO:0044389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044389", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 210, "end_pos": 269, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SD62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD62" }, { "id": "PS50179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VHS", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 143, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD66-1", "uniprot_ac": "A0AAA9SD66", "uniprot_id": "A0AAA9SD66_BOVIN", "mass": { "chemical_mass": 37466.0, "monoisotopic_mass": 37466.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SD66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66", "locus": {} } ], "crossref": [ { "id": "A0AAA9SD66", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD66", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SD66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRKHKNKQHAHGKRHQVQGDTQEAHASAAAAPGEECPSSPSSAPQGSPPSSPAAGDGQELQGAMAPSSPVAEASWAGSEEGAQGPEEESADAARAALLARSIRKDPLMRKASLVMDFLLERYTKKEPITQNGMLNVIGRKYKQHLPEILSRASERVELVFGLELKEVDCSRNIYTLVNKFSLGVEEGSSDEEELPKSGLLMALLGIIFTKGNRASEEEIWDFLNVLGIHAGKKHSIFGEPRKLITKDLVQKGYLIYRRVPNSDPPGYEFLWGPRAYAETTKMKVLEVLAKIQDKVPSSFPDLYDEALRDQVERAALRGAARAPTMAEASAPTRAKSYSSSHI", "length": 343, "header": "tr|A0AAA9SD66-1|A0AAA9SD66_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SD66-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66/entry#A0AAA9SD66-1", "sequence": { "sequence": "MPRKHKNKQHAHGKRHQVQGDTQEAHASAAAAPGEECPSSPSSAPQGSPPSSPAAGDGQELQGAMAPSSPVAEASWAGSEEGAQGPEEESADAARAALLARSIRKDPLMRKASLVMDFLLERYTKKEPITQNGMLNVIGRKYKQHLPEILSRASERVELVFGLELKEVDCSRNIYTLVNKFSLGVEEGSSDEEELPKSGLLMALLGIIFTKGNRASEEEIWDFLNVLGIHAGKKHSIFGEPRKLITKDLVQKGYLIYRRVPNSDPPGYEFLWGPRAYAETTKMKVLEVLAKIQDKVPSSFPDLYDEALRDQVERAALRGAARAPTMAEASAPTRAKSYSSSHI", "length": 343, "header": "tr|A0AAA9SD66-1|A0AAA9SD66_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SD66-1" }, "locus": { "chromosome": "NKLS02000337.1", "start_pos": 38285, "end_pos": 37257, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106717.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106717.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081798.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081798.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD66" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 108, "end_pos": 307, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD68-1", "uniprot_ac": "A0AAA9SD68", "uniprot_id": "A0AAA9SD68_BOVIN", "mass": { "chemical_mass": 72517.0, "monoisotopic_mass": 72517.0 }, "refseq": {}, "gene_names": [ { "name": "CAGE1", "type": "recommended", "evidence": [ { "id": "A0AAA9SD68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68" } ] } ], "protein_names": [ { "name": "Cancer-associated gene protein 1 N-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SD68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAGE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68", "locus": {} } ], "crossref": [ { "id": "A0AAA9SD68", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD68", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR36864", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36864", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36864:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36864:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SD68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ITEEPELQHYVCDDAEDTNIQEDSFKEENPMGTSTFTHTDQFALECVRQPSRSPPLIHCSEETLKFMEMPLANSNATESALNPSQSQDFVCEIAGSSKGVQNSMDIPEMSVRHQKEVPEKGRWSPQMVSTWAPTGICWSDGASQEACLIPDAEQSLESLQPLEEDMALNEVLRKLKLANKEQETRIQDLEHRNTYLEKKVEELQTNTTKQHVFVDIINKLKEKVEELIEEKYRIKLEKNDTEKTLQSLHEILVTTQNHLQECRSEKETLQLEFKKLKGNYASLEERYMTQCMEMDSALSKKEEEIERLQQLKGELEKATSAALDLLKRERETREQEVLSLREEFQKRERKHLDERENLKSKLEKLVAQVQKVQFLSDSEKAKNAELQQQIDEVKNENTKHQQQVARSEEQNCVPKCEIARLKEILEGVTESDVAKDTKMTHSNLFPNHSPCEEGSANPPDMKRTSQPTSRILSLLALMVELLPHQDIINPDAEHFKENEKVSDMPQKLKSFHLKKKILDKEVTEFDSKEAKNVRDVPVVLGAKLNQPHNLNEELDFLVTSYEEIIKCADQRLVISHSQIAHLEERNKQLEDLIRRSRERVRKPRPRSHPKPLTVMPVILEGNRNDLD", "length": 627, "header": "tr|A0AAA9SD68-1|A0AAA9SD68_BOVIN Isoform 1 of Cancer-associated gene protein 1 N-terminal domain-containing protein OS=Bos taurus OX=9913 GN=CAGE1 PE=4 SV=1 CANONICAL=A0AAA9SD68-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68/entry#A0AAA9SD68-1", "sequence": { "sequence": "ITEEPELQHYVCDDAEDTNIQEDSFKEENPMGTSTFTHTDQFALECVRQPSRSPPLIHCSEETLKFMEMPLANSNATESALNPSQSQDFVCEIAGSSKGVQNSMDIPEMSVRHQKEVPEKGRWSPQMVSTWAPTGICWSDGASQEACLIPDAEQSLESLQPLEEDMALNEVLRKLKLANKEQETRIQDLEHRNTYLEKKVEELQTNTTKQHVFVDIINKLKEKVEELIEEKYRIKLEKNDTEKTLQSLHEILVTTQNHLQECRSEKETLQLEFKKLKGNYASLEERYMTQCMEMDSALSKKEEEIERLQQLKGELEKATSAALDLLKRERETREQEVLSLREEFQKRERKHLDERENLKSKLEKLVAQVQKVQFLSDSEKAKNAELQQQIDEVKNENTKHQQQVARSEEQNCVPKCEIARLKEILEGVTESDVAKDTKMTHSNLFPNHSPCEEGSANPPDMKRTSQPTSRILSLLALMVELLPHQDIINPDAEHFKENEKVSDMPQKLKSFHLKKKILDKEVTEFDSKEAKNVRDVPVVLGAKLNQPHNLNEELDFLVTSYEEIIKCADQRLVISHSQIAHLEERNKQLEDLIRRSRERVRKPRPRSHPKPLTVMPVILEGNRNDLD", "length": 627, "header": "tr|A0AAA9SD68-1|A0AAA9SD68_BOVIN Isoform 1 of Cancer-associated gene protein 1 N-terminal domain-containing protein OS=Bos taurus OX=9913 GN=CAGE1 PE=4 SV=1 CANONICAL=A0AAA9SD68-1" }, "locus": { "chromosome": "23", "start_pos": 47997560, "end_pos": 47965435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104925.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104925.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080270.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080270.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD68" }, { "id": "PF15066", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15066" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cancer-associated gene protein 1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 92, "end_pos": 370, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 239, "end_pos": 241 }, { "start_pos": 447, "end_pos": 449 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD69-1", "uniprot_ac": "A0AAA9SD69", "uniprot_id": "A0AAA9SD69_BOVIN", "mass": { "chemical_mass": 77010.0, "monoisotopic_mass": 77010.0 }, "refseq": { "ac": "XP_024845417", "name": "ephexin-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845417" }, "gene_names": [ { "name": "NGEF", "type": "recommended", "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ] }, { "name": "NGEF", "type": "synonym", "evidence": [ { "id": "XP_024845417", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845417" } ] } ], "protein_names": [ { "name": "Ephexin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69/entry#names_and_taxonomy" } ] }, { "name": "Eph-interacting exchange protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69/entry#names_and_taxonomy" } ] }, { "name": "Neuronal guanine nucleotide exchange factor", "type": "synonym", "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69/entry#names_and_taxonomy" } ] }, { "name": "ephexin-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845417", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845417" } ] } ], "function": [ { "annotation": "Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69#function" }, { "database": "UniProtKB", "id": "ARBA00056735", "url": "https://www.uniprot.org/uniprotkb/ARBA00056735#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NGEF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69", "locus": { "chromosome": "3", "start_pos": 112609162, "end_pos": 112707665, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008942", "url": "https://www.ensembl.org/id/ENSBTAG00000008942" } ] } } ], "crossref": [ { "id": "A0AAA9SD69", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD69", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01221", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01221", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540756", "url": "https://www.ncbi.nlm.nih.gov/gene/540756", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12845:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12845:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845417", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845417", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPHTDQEAQDKASHTKPIQRNSTFNRAVRLRSRGKARGTSEGNPGYPADPLENENSVNEPLTLNLPQSRKHLWRIPIQTDPGAERTSESSSTPGNGATPEEFPALADSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGAADGCPSSEEAPEEDEGEEEEPASPPERKALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEEIRLQEAMFELITSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELERRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPLSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELELVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRAEELEDQGQTLANVFILRLLENSDDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTEDGWIFGERLHDQERGWFPSNMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ", "length": 667, "header": "tr|A0AAA9SD69-1|A0AAA9SD69_BOVIN Isoform 1 of Ephexin-1 OS=Bos taurus OX=9913 GN=NGEF PE=4 SV=1 CANONICAL=A0AAA9SD69-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69/entry#A0AAA9SD69-1", "sequence": { "sequence": "MPHTDQEAQDKASHTKPIQRNSTFNRAVRLRSRGKARGTSEGNPGYPADPLENENSVNEPLTLNLPQSRKHLWRIPIQTDPGAERTSESSSTPGNGATPEEFPALADSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGAADGCPSSEEAPEEDEGEEEEPASPPERKALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEEIRLQEAMFELITSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELERRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPLSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELELVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRAEELEDQGQTLANVFILRLLENSDDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTEDGWIFGERLHDQERGWFPSNMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ", "length": 667, "header": "tr|A0AAA9SD69-1|A0AAA9SD69_BOVIN Isoform 1 of Ephexin-1 OS=Bos taurus OX=9913 GN=NGEF PE=4 SV=1 CANONICAL=A0AAA9SD69-1" }, "locus": { "chromosome": "3", "start_pos": 112702998, "end_pos": 112609994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087826.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087826.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084063.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084063.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 92, "start_aa": "Thr", "end_pos": 92, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr92", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "ephrin receptor signaling pathway", "id": "GO:0048013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "negative regulation of dendritic spine morphogenesis", "id": "GO:0061002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061002", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "regulation of synapse pruning", "id": "GO:1905806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905806", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ephrin receptor binding", "id": "GO:0046875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046875", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 623, "end_pos": 625, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 414, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 446, "end_pos": 558, "start_aa": "Trp", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD69" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 569, "end_pos": 630, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 92 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 21, "end_pos": 23 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 623, "end_pos": 625 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD78-1", "uniprot_ac": "A0AAA9SD78", "uniprot_id": "A0AAA9SD78_BOVIN", "mass": { "chemical_mass": 31741.0, "monoisotopic_mass": 31741.0 }, "refseq": { "ac": "XP_003587703", "name": "exosome complex component RRP42", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587703" }, "gene_names": [ { "name": "EXOSC7", "type": "recommended", "evidence": [ { "id": "A0AAA9SD78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ] }, { "name": "EXOSC7", "type": "synonym", "evidence": [ { "id": "XP_003587703", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587703" } ] } ], "protein_names": [ { "name": "Exosome component 7", "type": "recommended", "evidence": [ { "id": "A0AAA9SD78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal RNA-processing protein 42", "type": "synonym", "evidence": [ { "id": "A0AAA9SD78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78/entry#names_and_taxonomy" } ] }, { "name": "exosome complex component RRP42", "type": "synonym", "evidence": [ { "id": "XP_003587703", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587703" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXOSC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78", "locus": { "chromosome": "22", "start_pos": 54176878, "end_pos": 54204579, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018329", "url": "https://www.ensembl.org/id/ENSBTAG00000018329" } ] } } ], "crossref": [ { "id": "A0AAA9SD78", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD78", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11367", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11367", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100847343", "url": "https://www.ncbi.nlm.nih.gov/gene/100847343", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847343", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847343", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YNTRIPK", "url": "https://omabrowser.org/oma/group/YNTRIPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11097:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11097:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03725", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03725", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587703", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587703", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVALSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSIDLKSLCISPREHCWVLYVDVLLLECGGNLFDAISVAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIQLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCIRKVGKGSLDPESIFEMLETGKRVGKVLHASLQSILHKEESLGPKRQKVGFLG", "length": 291, "header": "tr|A0AAA9SD78-1|A0AAA9SD78_BOVIN Isoform 1 of Exosome component 7 OS=Bos taurus OX=9913 GN=EXOSC7 PE=3 SV=1 CANONICAL=A0AAA9SD78-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78/entry#A0AAA9SD78-1", "sequence": { "sequence": "MASVALSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSIDLKSLCISPREHCWVLYVDVLLLECGGNLFDAISVAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIQLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCIRKVGKGSLDPESIFEMLETGKRVGKVLHASLQSILHKEESLGPKRQKVGFLG", "length": 291, "header": "tr|A0AAA9SD78-1|A0AAA9SD78_BOVIN Isoform 1 of Exosome component 7 OS=Bos taurus OX=9913 GN=EXOSC7 PE=3 SV=1 CANONICAL=A0AAA9SD78-1" }, "locus": { "chromosome": "22", "start_pos": 54204380, "end_pos": 54177319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106035.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106035.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081496.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081496.1" } ] } }, { "isoform_ac": "A0AAA9TU56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78/entry#A0AAA9TU56-1", "sequence": { "sequence": "MASVALSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSIDLKSLCISPREHCWVLYVDVLLLECGGNLFDAISVAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIQLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCIRKVGKGSLDPESIFEMLEHLCMAVTSKTLFRLASAWARCCMPPCRVFYTRRRAWGPRDRKSDSWADVHSSLQLPNVRLLLFPGS", "length": 323, "header": "tr|A0AAA9TU56-1|A0AAA9TU56_BOVIN Computationally mapped isoform of Exosome component 7 OS=Bos taurus OX=9913 GN=EXOSC7 PE=3 SV=1 CANONICAL=A0AAA9SD78-1" }, "locus": { "chromosome": "22", "start_pos": 54204380, "end_pos": 54177261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106320.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106320.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101906.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101906.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 90, "start_aa": "Thr", "end_pos": 90, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr90", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100847343", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847343", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5K1UMB9-1", "protein_name": "Exosome component 7", "gene_name": "EXOSC7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASVALSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSANATPEFEGRGGDELGTEIANTLYRIFNNKGSIDLKSLCISPREHCWILYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIQLNVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVAVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHTSLQSLLHKEESLGPKRQKVGFLG", "length": 291 }, "evidence": [ { "id": "A0AAA9SD78", "url": "https://omabrowser.org/oma/group/A0AAA9SD78/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZNY7-1", "protein_name": "Exosome component 7", "gene_name": "Exosc7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASVSLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLERPSEGYLEFFVDCSANATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLRSLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGCRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMESSKRVGKVLHMSLQSLLHKEESLGPKRPKVGFLG", "length": 291 }, "evidence": [ { "id": "A0AAA9SD78", "url": "https://omabrowser.org/oma/group/A0AAA9SD78/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15024-1", "protein_name": "Exosome complex component RRP42", "gene_name": "EXOSC7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG", "length": 291 }, "evidence": [ { "id": "A0AAA9SD78", "url": "https://omabrowser.org/oma/group/A0AAA9SD78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54VM4-1", "protein_name": "Putative exosome complex exonuclease RRP42", "gene_name": "exosc7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQKISPSESLFIQQGVENNIRSDGRNRVDYRNFAIETGEIIHANGSARVKLSQTEVLVGVKAEITHIQSEITSNLQQSDTSKRLVFSVNCCPSASPEFEGKGSEFLNIELSKQLERLYSHPNVIKNLKLTNPIISNNNNNNNKIKEAEEGKEKEKEGDIITNSGDDNCFSIVSGKYYWTLYVDAIVLDSDGNLFDALSIACRSALQNTRIPRVKAIQGEYEEITFEVSDDPEDTLSLSIDNVPICVTLTKIGNQFVIDTTLQEELCMNARLTVGVNSLANICSIQKGGIDGLDPTTINQMINTAKVVGVKILNIMDKTLKEISN", "length": 324 }, "evidence": [ { "id": "A0AAA9SD78", "url": "https://omabrowser.org/oma/group/A0AAA9SD78/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9D0M0-1", "protein_name": "Exosome complex exonuclease RRP42", "gene_name": "Exosc7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASVALSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSANATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLRSLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGAKDIELSDDPYDCIRLSVENVPCIVTLCKIGCRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMESSKRVGKVLHVSLQSLLHKEESLGPKRPRVGFLG", "length": 291 }, "evidence": [ { "id": "A0AAA9SD78", "url": "https://omabrowser.org/oma/group/A0AAA9SD78/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" }, { "name": "exosome (RNase complex)", "id": "GO:0000178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" }, { "name": "RNA catabolic process", "id": "GO:0006401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006401", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD78" }, { "id": "PF01138", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01138" }, { "id": "PF03725", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03725" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Exoribonuclease phosphorolytic", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 166, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 90 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD90-1", "uniprot_ac": "A0AAA9SD90", "uniprot_id": "A0AAA9SD90_BOVIN", "mass": { "chemical_mass": 35999.0, "monoisotopic_mass": 35999.0 }, "refseq": {}, "gene_names": [ { "name": "OR12D2F", "type": "recommended", "evidence": [ { "id": "A0AAA9SD90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SD90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR12D2F", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90", "locus": { "chromosome": "23", "start_pos": 29261037, "end_pos": 29261987, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056760", "url": "https://www.ensembl.org/id/ENSBTAG00000056760" } ] } } ], "crossref": [ { "id": "A0AAA9SD90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD90", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15915", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15915", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SD90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VICLFFQVMLNQTSVTEFLLLGVTDIQVLQPVLFVIFLATYIVNVAGNAAILMVVISDPRLHSPMYFFLGNLSCLDICYSTVTLPKMLENFLSIHKAISFLGCISQLHFFHFLGSTEVMLLAVMGFDRFVAICKPLHYTVIMNHQVCTQMAVTVWIIGFFHALLHSVMTSRLNFCGSNHIHHFFCDVKPLLELACGNTDLNEWLLHTVTETIAMGSFFLILLSYFYIIIYLFFKTHSCRMLRKTLSTCASHFMLVVLLFGPVFFIYIRPASGSSMDHDRTVAIMYSVVTPVLNPLIYTLRNKEVKGALKRVIRRRP", "length": 316, "header": "tr|A0AAA9SD90-1|A0AAA9SD90_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR12D2F PE=3 SV=1 CANONICAL=A0AAA9SD90-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90/entry#A0AAA9SD90-1", "sequence": { "sequence": "VICLFFQVMLNQTSVTEFLLLGVTDIQVLQPVLFVIFLATYIVNVAGNAAILMVVISDPRLHSPMYFFLGNLSCLDICYSTVTLPKMLENFLSIHKAISFLGCISQLHFFHFLGSTEVMLLAVMGFDRFVAICKPLHYTVIMNHQVCTQMAVTVWIIGFFHALLHSVMTSRLNFCGSNHIHHFFCDVKPLLELACGNTDLNEWLLHTVTETIAMGSFFLILLSYFYIIIYLFFKTHSCRMLRKTLSTCASHFMLVVLLFGPVFFIYIRPASGSSMDHDRTVAIMYSVVTPVLNPLIYTLRNKEVKGALKRVIRRRP", "length": 316, "header": "tr|A0AAA9SD90-1|A0AAA9SD90_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR12D2F PE=3 SV=1 CANONICAL=A0AAA9SD90-1" }, "locus": { "chromosome": "23", "start_pos": 29261987, "end_pos": 29261040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109000.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109000.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081511.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD90" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 297, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDA7-1", "uniprot_ac": "A0AAA9SDA7", "uniprot_id": "A0AAA9SDA7_BOVIN", "mass": { "chemical_mass": 71872.0, "monoisotopic_mass": 71872.0 }, "refseq": {}, "gene_names": [ { "name": "GRK6", "type": "recommended", "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.-", "type": "synonym", "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7", "locus": { "chromosome": "7", "start_pos": 38940650, "end_pos": 38925963, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043994", "url": "https://www.ensembl.org/id/ENSBTAG00000043994" } ] } } ], "crossref": [ { "id": "A0AAA9SDA7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000043994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05630", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05630", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521413", "url": "https://www.ncbi.nlm.nih.gov/gene/521413", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521413", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521413", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NYLNPKC", "url": "https://omabrowser.org/oma/group/NYLNPKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP29", "url": "https://www.orthodb.org/?gene=E1BP29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "12008", "url": "https://www.rhea-db.org/rhea/12008", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP29", "url": "https://www.uniprot.org/uniprotkb/E1BP29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP29-1", "url": "https://www.uniprot.org/uniprotkb/E1BP29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCIAFLDGVAEYEVTPDEKRKACGLRLMQNFLSHTGPDLIPEVPRQLVTNCAQRLEEGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSEHFSPQARSLCTQLLCKDPSERLGCGGGGAQEVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQVIPSSVLPRPPAQLLGTAGGRQSWCPYAGEWASSSCVSGAQGLWPHSRLSPTPGWAHGLFSLSRGLLWKLQRQ", "length": 632, "header": "tr|A0AAA9SDA7-1|A0AAA9SDA7_BOVIN Isoform 1 of G protein-coupled receptor kinase OS=Bos taurus OX=9913 GN=GRK6 PE=3 SV=2 CANONICAL=A0AAA9SDA7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7/entry#A0AAA9SDA7-1", "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCIAFLDGVAEYEVTPDEKRKACGLRLMQNFLSHTGPDLIPEVPRQLVTNCAQRLEEGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSEHFSPQARSLCTQLLCKDPSERLGCGGGGAQEVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQVIPSSVLPRPPAQLLGTAGGRQSWCPYAGEWASSSCVSGAQGLWPHSRLSPTPGWAHGLFSLSRGLLWKLQRQ", "length": 632, "header": "tr|A0AAA9SDA7-1|A0AAA9SDA7_BOVIN Isoform 1 of G protein-coupled receptor kinase OS=Bos taurus OX=9913 GN=GRK6 PE=3 SV=2 CANONICAL=A0AAA9SDA7-1" }, "locus": { "chromosome": "7", "start_pos": 38939539, "end_pos": 38926063, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091746.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091746.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083391.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083391.2" } ] } }, { "isoform_ac": "A0AAA9SIA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7/entry#A0AAA9SIA4-1", "sequence": { "sequence": "MQCPVIGAWSLPGDSAALCHLSGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCIAFLDGVAEYEVTPDEKRKACGLRLMQNFLSHTGPDLIPEVPRQLVTNCAQRLEEGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSEHFSPQARSLCTQLLCKDPSERLGCGGGGAQEVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPARLELPTRL", "length": 587, "header": "tr|A0AAA9SIA4-1|A0AAA9SIA4_BOVIN Computationally mapped isoform of G protein-coupled receptor kinase OS=Bos taurus OX=9913 GN=GRK6 PE=3 SV=1 CANONICAL=A0AAA9SDA7-1" }, "locus": { "chromosome": "7", "start_pos": 38939582, "end_pos": 38929435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098017.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098017.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082280.1" } ] } }, { "isoform_ac": "A0AAA9SX84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7/entry#A0AAA9SX84-1", "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCIAFLDGVAEYEVTPDEKRKACGLRLMQNFLSHTGPDLIPEVPRQLVTNCAQRLEEGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSEHFSPQARSLCTQLLCKDPSERLGCGGGGAQEVKEHPLFKKLNFKRLGAGMLEPPFKPDMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPARLELPTRL", "length": 536, "header": "tr|A0AAA9SX84-1|A0AAA9SX84_BOVIN Computationally mapped isoform of G protein-coupled receptor kinase OS=Bos taurus OX=9913 GN=GRK6 PE=3 SV=1 CANONICAL=A0AAA9SDA7-1" }, "locus": { "chromosome": "7", "start_pos": 38939582, "end_pos": 38926063, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131221.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131221.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088829.1" } ] } }, { "isoform_ac": "E1BP29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7/entry#E1BP29-1", "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCIAFLDGVAEYEVTPDEKRKACGLRLMQNFLSHTGPDLIPEVPRQLVTNCAQRLEEGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSEHFSPQARSLCTQLLCKDPSERLGCGGGGAQEVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQRTAVETAATVRKSFPPASSSPPASSPQPGAPPGGWR", "length": 595, "header": "tr|E1BP29-1|E1BP29_BOVIN Computationally mapped isoform of G protein-coupled receptor kinase OS=Bos taurus OX=9913 GN=GRK6 PE=3 SV=3 CANONICAL=A0AAA9SDA7-1" }, "locus": { "chromosome": "7", "start_pos": 38939619, "end_pos": 38926063, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061163.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061163.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053464.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053464.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 611, "start_aa": "Thr", "end_pos": 611, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr611", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521413", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521413", "resource": "KEGG Pathway" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "O70293-1", "protein_name": "G protein-coupled receptor kinase 6", "gene_name": "Grk6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVSEYEVTPDEKRKACGRRLMQNFLSHTGPDLIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSTAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL", "length": 576 }, "evidence": [ { "id": "A0AAA9SDA7", "url": "https://omabrowser.org/oma/group/A0AAA9SDA7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P43250-1", "protein_name": "G protein-coupled receptor kinase 6", "gene_name": "GRK6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL", "length": 576 }, "evidence": [ { "id": "A0AAA9SDA7", "url": "https://omabrowser.org/oma/group/A0AAA9SDA7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97711-1", "protein_name": "G protein-coupled receptor kinase 6", "gene_name": "Grk6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVAEYEVTPDEKRKACGCRLMQNFLSHTGPDLIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLTVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSPQARSLCSQLPNKDPAERLGCRGGGAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL", "length": 576 }, "evidence": [ { "id": "A0AAA9SDA7", "url": "https://omabrowser.org/oma/group/A0AAA9SDA7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "pmid": "" }, { "name": "G protein-coupled receptor kinase activity", "id": "GO:0004703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004703", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "pmid": "" }, { "name": "beta-adrenergic receptor kinase activity", "id": "GO:0047696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047696", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12008", "name": "", "equation": "[G protein-coupled receptor] + ATP = [G protein-coupled receptor]-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P43249-1", "A0A3Q1MYX1-1", "A0AAA9SDA7-1", "P21146-1", "P26818-1" ], "evidence": [ { "id": "12008", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12008" } ] }, { "id": "R-BTA-8851797", "name": "ADRB2 in ADRB2:GRK complex is phosphorylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21146-1", "P43249-1", "P26818-1", "A0AAA9SDA7-1" ], "evidence": [ { "id": "R-BTA-8851797", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8851797" } ] }, { "id": "R-BTA-8982641", "name": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21146-1", "P43249-1", "P26818-1", "A0AAA9SDA7-1" ], "evidence": [ { "id": "R-BTA-8982641", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8982641" } ] }, { "id": "R-BTA-8982645", "name": "GRKs bind ADRB2:Catecholamine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P21146-1", "P43249-1", "P26818-1", "A0AAA9SDA7-1" ], "evidence": [ { "id": "R-BTA-8982645", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8982645" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MYX1", "gene_name": "GRK4", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1MYX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MYX1" } ] } ] }, { "uniprot_ac": "A0AAA9SDA7", "gene_name": "GRK6", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" } ] } ] }, { "uniprot_ac": "P21146", "gene_name": "GRK2", "activity": [ { "ec_number": "2.7.11.15", "activity": "[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P21146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21146" } ] }, { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P21146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21146" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "P21146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P21146" } ] } ] }, { "uniprot_ac": "P26818", "gene_name": "GRK3", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P26818", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26818" } ] }, { "ec_number": "2.7.11.15", "activity": "[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P26818", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26818" } ] }, { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P26818", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26818" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "P26818", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26818" } ] } ] }, { "uniprot_ac": "P43249", "gene_name": "GRK5", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P43249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43249" } ] }, { "ec_number": "2.7.11.16", "activity": "[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+).", "evidence": [ { "id": "P43249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43249" } ] }, { "ec_number": "2.7.11.16", "activity": "", "evidence": [ { "id": "P43249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43249" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" }, { "id": "PS51285", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51285" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AGC-kinase C-terminal", "eco_id": "ECO_0000259", "start_pos": 449, "end_pos": 514, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 448, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA7" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 171, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 611 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDC2-1", "uniprot_ac": "A0AAA9SDC2", "uniprot_id": "A0AAA9SDC2_BOVIN", "mass": { "chemical_mass": 15388.0, "monoisotopic_mass": 15388.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Immunoglobulin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SDC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDC2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19256:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19256:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SSNMEEDKLSVMRATGSSVVIECDLTGSYIHWYKFQEGAVPGRLLYYDVYYSKVVLGSGISEGKYHVYKGTGKSYTFVISNLQESDSGTYYCAVWEKHIGLDFLYTALEILLVAAKTALIHRIDQPLLTSCPQFFSL", "length": 137, "header": "tr|A0AAA9SDC2-1|A0AAA9SDC2_BOVIN Isoform 1 of Immunoglobulin domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SDC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2/entry#A0AAA9SDC2-1", "sequence": { "sequence": "SSNMEEDKLSVMRATGSSVVIECDLTGSYIHWYKFQEGAVPGRLLYYDVYYSKVVLGSGISEGKYHVYKGTGKSYTFVISNLQESDSGTYYCAVWEKHIGLDFLYTALEILLVAAKTALIHRIDQPLLTSCPQFFSL", "length": 137, "header": "tr|A0AAA9SDC2-1|A0AAA9SDC2_BOVIN Isoform 1 of Immunoglobulin domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SDC2-1" }, "locus": { "chromosome": "4", "start_pos": 82589372, "end_pos": 82588962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110715.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110715.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083407.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083407.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDC2" }, { "id": "SM00409", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 111, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDF5-1", "uniprot_ac": "A0AAA9SDF5", "uniprot_id": "A0AAA9SDF5_BOVIN", "mass": { "chemical_mass": 56585.0, "monoisotopic_mass": 56585.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC8", "type": "recommended", "evidence": [ { "id": "A0AAA9SDF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 8", "type": "synonym", "evidence": [ { "id": "A0AAA9SDF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5", "locus": { "chromosome": "18", "start_pos": 53700961, "end_pos": 53691729, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018181", "url": "https://www.ensembl.org/id/ENSBTAG00000018181" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018181", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018181", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RRRVPQM", "url": "https://omabrowser.org/oma/group/RRRVPQM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6R7X9", "url": "https://www.orthodb.org/?gene=F6R7X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47741", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47741", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47741:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47741:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R7X9", "url": "https://www.uniprot.org/uniprotkb/F6R7X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R7X9-1", "url": "https://www.uniprot.org/uniprotkb/F6R7X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQFLEEEGRTLEDVARIIEKSTPHPPQPPRKSKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRNKADKGRKGAGRGRKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRGEKKPSAPPPRRRVNLPVPMFDDSPGPQQSKADRWRECVSQVSWGKLKRRVKGWAPKSSPGVGEARQASTRVERDSASVPGSASLGCNVGNARDGRVPETPPRRWRPQINWASFRRRRREETASRAQGGEAADEQRREAIDNQRREAIDNQRGEAIDNQRVEAVGNQIGEAVDNQRAGPIAVQEAEAVDNQRADALAVQGAEAIPVQGAEALADPRAEAAEDLRPEAPVVQAAEAVPDGEEAGSVQRAEAVCNQRAETPAVQEAESSAAGRATGATAGARTRKPVKTVRFQTPGRFSWFRKRRRAFWHTPRLPTLPKRVPRAGEARSLRVLRAEARAEAEHGEQEDQL", "length": 510, "header": "tr|A0AAA9SDF5-1|A0AAA9SDF5_BOVIN Isoform 1 of Coiled-coil domain containing 8 OS=Bos taurus OX=9913 GN=CCDC8 PE=4 SV=1 CANONICAL=A0AAA9SDF5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5/entry#A0AAA9SDF5-1", "sequence": { "sequence": "MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQFLEEEGRTLEDVARIIEKSTPHPPQPPRKSKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRNKADKGRKGAGRGRKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRGEKKPSAPPPRRRVNLPVPMFDDSPGPQQSKADRWRECVSQVSWGKLKRRVKGWAPKSSPGVGEARQASTRVERDSASVPGSASLGCNVGNARDGRVPETPPRRWRPQINWASFRRRRREETASRAQGGEAADEQRREAIDNQRREAIDNQRGEAIDNQRVEAVGNQIGEAVDNQRAGPIAVQEAEAVDNQRADALAVQGAEAIPVQGAEALADPRAEAAEDLRPEAPVVQAAEAVPDGEEAGSVQRAEAVCNQRAETPAVQEAESSAAGRATGATAGARTRKPVKTVRFQTPGRFSWFRKRRRAFWHTPRLPTLPKRVPRAGEARSLRVLRAEARAEAEHGEQEDQL", "length": 510, "header": "tr|A0AAA9SDF5-1|A0AAA9SDF5_BOVIN Isoform 1 of Coiled-coil domain containing 8 OS=Bos taurus OX=9913 GN=CCDC8 PE=4 SV=1 CANONICAL=A0AAA9SDF5-1" }, "locus": { "chromosome": "18", "start_pos": 53701712, "end_pos": 53700961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084165.1" } ] } }, { "isoform_ac": "F6R7X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5/entry#F6R7X9-1", "sequence": { "sequence": "MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQFLEEEGRTLEDVARIIEKSTPHPPQPPRKSKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRNKADKGRKGAGRGRKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRGEKKPSAPPPRRRVNLPVPMFDDSPGPQQSKADRWRECVSQVSWGKLKRRVKGWAPKSSPGVGEARQASTRVERDSASVPGSASLGCNVGNARDGRVPETPPRRWRPQINWASFRRRRREETASRAQGGEAADEQRREAIDNQRREAIDNQRGEAIDNQRVEAVDNQRAGPIAVQEAEAVDNQRADALAVQGAEAIPVQGAEALADPRAEAAEDLRPEAPVVQAAEAVPDGEEAGSVQRAEAVCNQRAETPAVQEAESSAAGRATGATAGARTRKPVKTVRFQTPGRFSWFRKRRRAFWHTPRLPTLPKRVPRAGEARSLRVLRAEARAEAEHGEQEDQL", "length": 502, "header": "tr|F6R7X9-1|F6R7X9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 8 OS=Bos taurus OX=9913 GN=CCDC8 PE=4 SV=2 CANONICAL=A0AAA9SDF5-1" }, "locus": { "chromosome": "18", "start_pos": 53694237, "end_pos": 53692708, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024194.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024194.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024194.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024194.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 87, "start_aa": "Thr", "end_pos": 87, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr87", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BR87-1", "protein_name": "Coiled-coil domain containing 8", "gene_name": "CCDC8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQFLEEEGRTLEDVARIIEKSTPHPPQPPKKPKEPGSRRRVPQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKDDKDHKGTGRGRRLRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRGEKKPSAPPARRRVTLPVPMFEDNPGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRSSPGVGEARQASTRVERDGASVPGSSSLGEDRGNAGDGRVPENPPSRWRPKINWASFRRRRREEAPTRAQRTEAADDQRAEVVVVPGAEAIALQGAEAVDNQRAEAPAAQGAEDPTVQRVEAADNQRAEALAVQGAEAPAVQRAEAIPDQRAEAACSQRAEALAVQEAESSAAWRATGATPGARTRKPVKTVRFQTPGRFSWFRKRRRAFWHTPRLPTLPKRVPRAGEARSLRVLRPEARAEAEHEEQEDQL", "length": 471 }, "evidence": [ { "id": "A0AAA9SDF5", "url": "https://omabrowser.org/oma/group/A0AAA9SDF5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P62521-1", "protein_name": "Coiled-coil domain-containing protein 8", "gene_name": "Ccdc8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAVFRERLIQFLQEEGRTLEDVARIIEKSTPHPPQPPKKAKVPRVRRVPQMVTPPLRLVVGTYDSSNGSDSELSDFDTSKVKGNRGSGKTRKVRKMPVSYLGSKFLGSDESEDDQELVEAFLRRGEKKPSAPPPRRRVNLPVPMFENNLGPQPSKGDRWREYVSQVSWGKLKQRVRGWAPRSGSEVGQAQQSSIAERAGEMRHSHTSPDLDDSSRNTGDLSDQTLITRRWKPKIKWVSLRRCRKEQVPPLAHGTAEEPPEAAENQGAGAAAEHGVEAAASQRPEAAASPRAEAAANPRAEATANPRAEAAANPRAEAAASPRAEAAANPRAEAAANPRAEATANPRAEAAANPRAEATANPRAEAAVNPRTEAAVNPRTEAAANPRAEAAVNPRAEATASPRAEAEVNQKTEATASPRAETAASPRVEAAASLRVEAAASPRAEATVSPRAEAVATPRAETAASARVEAAANLRAGVLPDQRAEAIDSQRAEGPVNQSTGATENQRVEVLADQRAGVLHDQREEAGPQAILEASADSGSRARKQVKTVRFQTPGRFSWFHMRRKAFWHTPRLPTLPKRGPRAGAGEARSLRVLRADTRADMEHREQEEQL", "length": 643 }, "evidence": [ { "id": "A0AAA9SDF5", "url": "https://omabrowser.org/oma/group/A0AAA9SDF5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H0W5-1", "protein_name": "Coiled-coil domain-containing protein 8", "gene_name": "CCDC8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIMEKSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQGPRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMFEDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAPEGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL", "length": 538 }, "evidence": [ { "id": "A0AAA9SDF5", "url": "https://omabrowser.org/oma/group/A0AAA9SDF5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5" } ], "pmid": "" }, { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "3M complex", "id": "GO:1990393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 87 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDH1-1", "uniprot_ac": "A0AAA9SDH1", "uniprot_id": "A0AAA9SDH1_BOVIN", "mass": { "chemical_mass": 17856.0, "monoisotopic_mass": 17856.0 }, "refseq": {}, "gene_names": [ { "name": "ETV2", "type": "recommended", "evidence": [ { "id": "A0AAA9SDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ] } ], "protein_names": [ { "name": "ETS translocation variant 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1/entry#names_and_taxonomy" } ] }, { "name": "Ets-related protein 71", "type": "synonym", "evidence": [ { "id": "A0AAA9SDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.", "evidence": [ { "database": "UniProtKB", "id": "E1B7I2", "url": "https://www.uniprot.org/uniprotkb/E1B7I2#function" }, { "database": "UniProtKB", "id": "ARBA00053038", "url": "https://www.uniprot.org/uniprotkb/ARBA00053038#function" }, { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1#function" }, { "database": "UniProtKB", "id": "A0AAA9SEW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEW3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1", "locus": { "chromosome": "18", "start_pos": 46369616, "end_pos": 46366884, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013444", "url": "https://www.ensembl.org/id/ENSBTAG00000013444" } ] } } ], "crossref": [ { "id": "A0AAA9SDH1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013444", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013444", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514231", "url": "https://www.ncbi.nlm.nih.gov/gene/514231", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514231", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514231", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GLHTDCT", "url": "https://omabrowser.org/oma/group/GLHTDCT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7I2", "url": "https://www.orthodb.org/?gene=E1B7I2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF209", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF209", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7I2", "url": "https://www.uniprot.org/uniprotkb/E1B7I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7I2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7I2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLWNWDEVSPQEVPLGHRMSGLEGAELNFYIPELAVQADTLTEDTCWKGPIQLWQFLLELLHDGARRSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRLPSLVYPDLMGGGLEAPTQ", "length": 153, "header": "tr|A0AAA9SDH1-1|A0AAA9SDH1_BOVIN Isoform 1 of ETS translocation variant 2 OS=Bos taurus OX=9913 GN=ETV2 PE=3 SV=1 CANONICAL=A0AAA9SDH1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1/entry#A0AAA9SDH1-1", "sequence": { "sequence": "MDLWNWDEVSPQEVPLGHRMSGLEGAELNFYIPELAVQADTLTEDTCWKGPIQLWQFLLELLHDGARRSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRLPSLVYPDLMGGGLEAPTQ", "length": 153, "header": "tr|A0AAA9SDH1-1|A0AAA9SDH1_BOVIN Isoform 1 of ETS translocation variant 2 OS=Bos taurus OX=9913 GN=ETV2 PE=3 SV=1 CANONICAL=A0AAA9SDH1-1" }, "locus": { "chromosome": "18", "start_pos": 46369594, "end_pos": 46367274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115826.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115826.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080379.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080379.1" } ] } }, { "isoform_ac": "A0AAA9SEW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1/entry#A0AAA9SEW3-1", "sequence": { "sequence": "MKYHHRKCLWGTGCQGWVGPRGVTMCVRWVRRWGPSLNLMGLCLTSLPAEGAELNFYIPELAVQADTLTEDTCWKGGCGLGPLGTGEEEPAPQALPWPGDWTDLPCSGTVSCSGVSQAPGPATWTGSEGATGQNYTTSAGSTNSWSRARVASSSTSWDYSIGPDGATCWGRSLGGELCADSTLPWAGPEASDCTTSWDSGLHTDCTSSSKEYQSSDLTTSSEPTQQSDRATLARYPKTNHRGPIQLWQFLLELLHDGARRSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRLPSLVYPDLMGGGLEAPTQ", "length": 345, "header": "tr|A0AAA9SEW3-1|A0AAA9SEW3_BOVIN Computationally mapped isoform of ETS translocation variant 2 OS=Bos taurus OX=9913 GN=ETV2 PE=3 SV=1 CANONICAL=A0AAA9SDH1-1" }, "locus": { "chromosome": "18", "start_pos": 46369594, "end_pos": 46367293, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084691.1" } ] } }, { "isoform_ac": "E1B7I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1/entry#E1B7I2-1", "sequence": { "sequence": "MDLWNWDEVSPQEVPLGHRMSGLEGAELNFYIPELAVQADTLTEDTCWKATTLFLAGLPQPDWSSTPYPEAAWGAEPAPQALPWPGDWTDLPCSGTVSCSGVSQAPGPATWTGSEGATGQNYTTSAGSTNSWSRARVASSSTSWDYSIGPDGATCWGRSLGGELCADSTLPWAGPEASDCTTSWDSGLHTDCTSSSKEYQSSDLTTSSEPTQQSDRATLARYPKTNHRGPIQLWQFLLELLHDGARRSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRLPSLVYPDLMGGGLEAPTQ", "length": 332, "header": "tr|E1B7I2-1|E1B7I2_BOVIN Computationally mapped isoform of ETS translocation variant 2 OS=Bos taurus OX=9913 GN=ETV2 PE=3 SV=1 CANONICAL=A0AAA9SDH1-1" }, "locus": { "chromosome": "18", "start_pos": 46369594, "end_pos": 46367274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017887.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017887.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017887.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017887.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514231", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514231", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZEY9-1", "protein_name": "ETS translocation variant 2", "gene_name": "Etv2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLWNWDEASVQEVPPGDKLTGLEGAEFGFYFPEVALQGDTPITPMNVESCWKGFPELDWNPALPHEEVPFEAEPVAHPLPWSRDWTDLGCNTSDPWSCASQTPGPAPPGTSPSPFVGFEGATGQNTATSAGGVPSWSHPPATWSTASWDCSAGPNGSTYWDSGLGGEAQADYKMSWGGSAGSDYTTTWNSGLQNCSIPFEGHQIPAFATPSKSSQQSDRATLTPYSKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNNREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVLKSGGRKYTYRFGGRVPVLACQDDMGHLPGAEGQ", "length": 336 }, "evidence": [ { "id": "A0AAA9SDH1", "url": "https://omabrowser.org/oma/group/A0AAA9SDH1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O00321-1", "protein_name": "ETS translocation variant 2", "gene_name": "ETV2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTATAETCWKGTSSSLASFPQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSWSGASQTLGPAPLGPGPIPAAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGDTYWGSGLGGEPRTDCTISWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCSEPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRGAETQ", "length": 342 }, "evidence": [ { "id": "A0AAA9SDH1", "url": "https://omabrowser.org/oma/group/A0AAA9SDH1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41163-1", "protein_name": "ETS translocation variant 2", "gene_name": "Etv2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLWNWDEASLQEVPPGDKLTGLGAEFGFYFPEVALQEDTPITPMNVEGCWKGFPELDWNPALPHEDVPFQAEPVAHPLPWSRDWTDLGCNTSDPWSCASQTPGPAPPGTSPSPFVGFEGATGQNPATSAGGVPSWSHPPAAWSTTSWDCSVGPSGATYWDNGLGGEAHEDYKMSWGGSAGSDYTTTWNTGLQDCSIPFEGHQSPAFTTPSKSNKQSDRATLTRYSKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVLKSGGRKYTYRFGGRVPVLAYQDDMGHLPGAEGQ", "length": 335 }, "evidence": [ { "id": "A0AAA9SDH1", "url": "https://omabrowser.org/oma/group/A0AAA9SDH1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH1" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 132, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDH2-1", "uniprot_ac": "A0AAA9SDH2", "uniprot_id": "A0AAA9SDH2_BOVIN", "mass": { "chemical_mass": 15310.0, "monoisotopic_mass": 15310.0 }, "refseq": {}, "gene_names": [ { "name": "LOC787554", "type": "recommended", "evidence": [ { "id": "A0AAA9SDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2" } ] } ], "protein_names": [ { "name": "KRAB domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC787554", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDH2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232:SF161", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232:SF161", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKVQGSVSFEDVAVGFSQEEWQILGPSQKALYWDVMLENYCNLVSVVLVDHPGSNAQHRPSRDFPFTGYQAPTPNSLFQLEQGGPPWTVEGAALSPTCSGYQATKPVVILTFEPREEPWKVEDEMQHQYFSVIVCA", "length": 137, "header": "tr|A0AAA9SDH2-1|A0AAA9SDH2_BOVIN Isoform 1 of KRAB domain-containing protein OS=Bos taurus OX=9913 GN=LOC787554 PE=4 SV=2 CANONICAL=A0AAA9SDH2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2/entry#A0AAA9SDH2-1", "sequence": { "sequence": "MSKVQGSVSFEDVAVGFSQEEWQILGPSQKALYWDVMLENYCNLVSVVLVDHPGSNAQHRPSRDFPFTGYQAPTPNSLFQLEQGGPPWTVEGAALSPTCSGYQATKPVVILTFEPREEPWKVEDEMQHQYFSVIVCA", "length": 137, "header": "tr|A0AAA9SDH2-1|A0AAA9SDH2_BOVIN Isoform 1 of KRAB domain-containing protein OS=Bos taurus OX=9913 GN=LOC787554 PE=4 SV=2 CANONICAL=A0AAA9SDH2-1" }, "locus": { "chromosome": "18", "start_pos": 57767454, "end_pos": 57755715, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114378.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114378.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081879.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081879.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 100, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDM3-1", "uniprot_ac": "A0AAA9SDM3", "uniprot_id": "A0AAA9SDM3_BOVIN", "mass": { "chemical_mass": 12717.0, "monoisotopic_mass": 12717.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SDM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDM3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQKVTQDQSDIISQVGQSVIFNCQYGIGWFTYYYSIYWYKQLPRGQMTPLIHQNSEHGNAGYGRYSVNFQKAYKSISLTISALQLEDSAKYFCGLRELSSKRTVTKEVHSA", "length": 111, "header": "tr|A0AAA9SDM3-1|A0AAA9SDM3_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SDM3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3/entry#A0AAA9SDM3-1", "sequence": { "sequence": "AQKVTQDQSDIISQVGQSVIFNCQYGIGWFTYYYSIYWYKQLPRGQMTPLIHQNSEHGNAGYGRYSVNFQKAYKSISLTISALQLEDSAKYFCGLRELSSKRTVTKEVHSA", "length": 111, "header": "tr|A0AAA9SDM3-1|A0AAA9SDM3_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SDM3-1" }, "locus": { "chromosome": "10", "start_pos": 23154566, "end_pos": 23154234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084240.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM3" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 105, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDM9-1", "uniprot_ac": "A0AAA9SDM9", "uniprot_id": "A0AAA9SDM9_BOVIN", "mass": { "chemical_mass": 30364.0, "monoisotopic_mass": 30364.0 }, "refseq": { "ac": "XP_002690578", "name": "transmembrane protein 202 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690578" }, "gene_names": [ { "name": "TMEM202", "type": "recommended", "evidence": [ { "id": "A0AAA9SDM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9" } ] }, { "name": "TMEM202", "type": "synonym", "evidence": [ { "id": "XP_002690578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690578" } ] } ], "protein_names": [ { "name": "Transmembrane protein 202", "type": "recommended", "evidence": [ { "id": "A0AAA9SDM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 202 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002690578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690578" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM202", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDM9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "785001", "url": "https://www.ncbi.nlm.nih.gov/gene/785001", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR050579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785001", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785001", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10671", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002690578", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690578", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NW10", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NW10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NW10-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NW10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEREEQTVFTFYYPEVPKVKGDRRYRRPTLPTQHPSALMPPQRRQQHVDQTHTYIRMFCGSLCGFSLLVLICMSPLNWVQFLVINDGLELYAGLWIPCNHELCWSHTPKPPYYLQYSRAFFLISVFTILVVLGWLFSSCLPRRGRVTGNLDLKVSMLSFISASCLLLCLILFLEQVDLYTSETVDSALLWPYQVNWGSDFIYLFAGIVSFLNYITSRSPSLDQDITAVPTEKSRLGFGPVTLPVEDALSELLTESSSEISQTHQI", "length": 265, "header": "tr|A0AAA9SDM9-1|A0AAA9SDM9_BOVIN Isoform 1 of Transmembrane protein 202 OS=Bos taurus OX=9913 GN=TMEM202 PE=4 SV=2 CANONICAL=A0AAA9SDM9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9/entry#A0AAA9SDM9-1", "sequence": { "sequence": "MEREEQTVFTFYYPEVPKVKGDRRYRRPTLPTQHPSALMPPQRRQQHVDQTHTYIRMFCGSLCGFSLLVLICMSPLNWVQFLVINDGLELYAGLWIPCNHELCWSHTPKPPYYLQYSRAFFLISVFTILVVLGWLFSSCLPRRGRVTGNLDLKVSMLSFISASCLLLCLILFLEQVDLYTSETVDSALLWPYQVNWGSDFIYLFAGIVSFLNYITSRSPSLDQDITAVPTEKSRLGFGPVTLPVEDALSELLTESSSEISQTHQI", "length": 265, "header": "tr|A0AAA9SDM9-1|A0AAA9SDM9_BOVIN Isoform 1 of Transmembrane protein 202 OS=Bos taurus OX=9913 GN=TMEM202 PE=4 SV=2 CANONICAL=A0AAA9SDM9-1" }, "locus": { "chromosome": "10", "start_pos": 19328458, "end_pos": 19312918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093816.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093816.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084245.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084245.2" } ] } }, { "isoform_ac": "A0ABI0NW10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9/entry#A0ABI0NW10-1", "sequence": { "sequence": "MEREEQTVFTFYYPEVPKVKGDRRYRRITSNIPGPSSSSLSSPYLLSLAGSSVLASLEEEG", "length": 61, "header": "tr|A0ABI0NW10-1|A0ABI0NW10_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=TMEM202 PE=4 SV=1 CANONICAL=A0AAA9SDM9-1" }, "locus": { "chromosome": "10", "start_pos": 19326835, "end_pos": 19312918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143331.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143331.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104624.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785001", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785001", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDR2-1", "uniprot_ac": "A0AAA9SDR2", "uniprot_id": "A0AAA9SDR2_BOVIN", "mass": { "chemical_mass": 177263.0, "monoisotopic_mass": 177263.0 }, "refseq": {}, "gene_names": [ { "name": "DIP2C", "type": "recommended", "evidence": [ { "id": "A0AAA9SDR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2" } ] } ], "protein_names": [ { "name": "Disco interacting C", "type": "synonym", "evidence": [ { "id": "A0AAA9SDR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIP2C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2", "locus": { "chromosome": "13", "start_pos": 46819195, "end_pos": 46527413, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006531", "url": "https://www.ensembl.org/id/ENSBTAG00000006531" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006531", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006531", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05905", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05905", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535136", "url": "https://www.ncbi.nlm.nih.gov/gene/535136", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535136", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535136", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LVWTYWT", "url": "https://omabrowser.org/oma/group/LVWTYWT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKT7", "url": "https://www.orthodb.org/?gene=F1MKT7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22754", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22754", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22754:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22754:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06464", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06464", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T094", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T094", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T094-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T094-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T856", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T856", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T856-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T856-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T998", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T998", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T998-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T998-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKT7", "url": "https://www.uniprot.org/uniprotkb/F1MKT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKT7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPTANGAAVVRCRLQHSEGAPRRMLQAGNIGVCDIRDAAVRERAASTAGNRPLFYFRFGVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIVCFFTENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1617, "header": "tr|A0AAA9SDR2-1|A0AAA9SDR2_BOVIN Isoform 1 of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=2 CANONICAL=A0AAA9SDR2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9SDR2-1", "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPTANGAAVVRCRLQHSEGAPRRMLQAGNIGVCDIRDAAVRERAASTAGNRPLFYFRFGVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIVCFFTENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1617, "header": "tr|A0AAA9SDR2-1|A0AAA9SDR2_BOVIN Isoform 1 of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=2 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46527612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097547.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097547.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081714.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081714.2" } ] } }, { "isoform_ac": "A0AAA9SZ13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9SZ13-1", "sequence": { "sequence": "MGSQNQTQLSDITQKGYEKKRSKLIGAYLPQPPTANGAAVVRCRLQHSEGAPRRMLQAGNIGVCDIRDAAVRERAASTAGNRPLFYFRFGVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1593, "header": "tr|A0AAA9SZ13-1|A0AAA9SZ13_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=1 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46636532, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121134.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121134.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090628.1" } ] } }, { "isoform_ac": "A0AAA9T094-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9T094-1", "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPRVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1556, "header": "tr|A0AAA9T094-1|A0AAA9T094_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=1 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46527612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091866.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091866.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089930.1" } ] } }, { "isoform_ac": "A0AAA9T856-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9T856-1", "sequence": { "sequence": "MQNQRKQHGLIQGPGLLIQGDITQKGYEKKRSKLIGAYLPQPPTANGAAVVRCRLQHSEGAPRRMLQAGNIGVCDIRDAAVRERAASTAGNRPLFYFRFGVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1603, "header": "tr|A0AAA9T856-1|A0AAA9T856_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=1 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46621586, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119210.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119210.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092021.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092021.1" } ] } }, { "isoform_ac": "A0AAA9T998-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9T998-1", "sequence": { "sequence": "MLQAGNIGVCDIRDAAVRERAASTAGNRPLFYFRFGVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1539, "header": "tr|A0AAA9T998-1|A0AAA9T998_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=1 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46684306, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117999.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117999.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093431.1" } ] } }, { "isoform_ac": "A0AAA9TQR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9TQR7-1", "sequence": { "sequence": "MQLKTVFKDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1475, "header": "tr|A0AAA9TQR7-1|A0AAA9TQR7_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=1 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46698201, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094909.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094909.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099655.1" } ] } }, { "isoform_ac": "A0AAA9U0Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#A0AAA9U0Z8-1", "sequence": { "sequence": "MVRWVRLPISRTVAGDITQKGYEKKRSKLIGAYLPQPPTANGAAVVRCRLQHSEGAPRRMLQAGNIGVCDIRDAAVRERAASTAGNRPLFYFRFGVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1598, "header": "tr|A0AAA9U0Z8-1|A0AAA9U0Z8_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=1 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46589591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091235.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091235.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103383.1" } ] } }, { "isoform_ac": "F1MKT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2/entry#F1MKT7-1", "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPRVDQALPPERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVLAQTHIENHSAPPDVTTYTSEHAIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEVGELCVCAVATGMSYYGLSGMTKNTFEVFPVTSSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1499, "header": "tr|F1MKT7-1|A0AAA9SDR2_BOVIN Computationally mapped isoform of Disco interacting C OS=Bos taurus OX=9913 GN=DIP2C PE=3 SV=3 CANONICAL=A0AAA9SDR2-1" }, "locus": { "chromosome": "13", "start_pos": 46818191, "end_pos": 46527612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015282.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015282.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015282.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015282.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 123, "start_aa": "Thr", "end_pos": 123, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr123", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535136", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535136", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BDU4-1", "protein_name": "Disco interacting C", "gene_name": "DIP2C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPRVDQALPPERRAPVTPSSSSRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVMAQTHIENHSAPPDVTTYTSEHSVQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAASMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYSLMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAVMCSVKPDGVPQLCRTDEVGELCVCAVATGTSYYGLSGMTKNTFEVFPVTGSGAPVSEYPFVRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRAWPPILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPAELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFSSRLSFGDTQTVWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLVVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1556 }, "evidence": [ { "id": "A0AAA9SDR2", "url": "https://omabrowser.org/oma/group/A0AAA9SDR2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZZB0-1", "protein_name": "Disco-interacting protein 2 homolog C", "gene_name": "Dip2c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPTANGAAVVRCRLQPGEGVPRRPFRSAHIGVCDIREAAARERAASAAGNRPLFYFRFGVDQALPQERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVMAQTHIENHSAPPDVTTYTSEHSIQVERPQGSTTSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLATRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYNILHKLGTKQEPMVRPGDRVALVFPNNDPAAFMVAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRIALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYALMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDVNLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEIGELCVCAVATGTSYYGLSGMTKNTFEVFPMTSSGAPISEYPFIRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKVRTEFLFLSEVLQWRAQTTPDHLLYTLLNCRGTIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRTWPLILDTDDLPKKRPAQIYKPSNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1616 }, "evidence": [ { "id": "A0AAA9SDR2", "url": "https://omabrowser.org/oma/group/A0AAA9SDR2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q12275-1", "protein_name": "Homeostatic regulator of DAG", "gene_name": "CRM2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDFSIPPTLPLDLQSRLNELIQDYKDENLTRKGYETKRKQLLDKFEISQMRPYTPLRSPNSRKSKHLHRRNTSLASSITSLPNSIDRRHSIYRVTTINSTSANNTPRRRSKRYTASLQSSLPGSSDENGSVKDAVYNPMIPLLPRHTGAENTSSGDSAMTDSLPLILRGRFEHYDGQTAMISINSKGKETFITWDKLYLKAERVAHELNKSHLYKMDKILLWYNKNDVIEFTIALLGCFISGMAAVPVSFETYSLREILEIIKVTNSKFVLISNACHRQLDNLYSSSNHSKVKLVKNDVFQQIKFVKTDDLGTYTKAKKTSPTFDIPNISYIEFTRTPLGRLSGVVMKHNILINQFETMTKILNSRSMPHWKQKSQSIRKPFHKKIMATNSRFVILNSLDPTRSTGLIMGVLFNLFTGNLMISIDSSILQRPGGYENIIDKFRADILLNDQLQLKQVVINYLENPESAFSKKHKIDFSCIKSCLTSCTTIDTDVSEMVVHKWLKNLGCIDAPFCYSPMLTLLDFGGIFISIRDQLGNLENFPIHNSKLRLQNELFINREKLKLNEVECSITAMINSSSSFKDYLKLETFGFPIPDITLCVVNPDTNTLVQDLTVGEIWISSNHITDEFYQMDKVNEFVFKAKLNYSEMFSWAKYEMPTNEKSQAVTEQLDTILNICPANTYFMRTKLMGFVHNGKIYVLSLIEDMFLQNRLIRLPNWAHTSNLLYAKKGNQSAQPKGNTGAESTKAIDISSLSGETSSGYKRVVESHYLQQITETVVRTVNTVFEVAAFELQHHKEEHFLVMVVESSLAKTEEESKNGETTDTTLMKFAETQRNKLETKMNDLTDQIFRILWIFHKIQPMCILVVPRDTLPRRYCSLELANSTVEKKFLNNDLSAQFVKFQFDNVILDFLPHSAYYNESILSEHLSKLRKMALQEEYAMIEPAYRNGGPVKPKLALQCSGVDYRDESVDTRSHTKLTDFKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVHKKVSWASFGKIVAGFLKKIVGSKIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVFVDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQKFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVTMTHSSLLNASKIVKETLQLRNNSPLFSICSHTSGLGFMFSCLLGIYTGASTCLFSLTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSAKNNTSGSLREDVFKGVRNIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRSYLDIPPVDLYLDPFSLREGIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVDGEFGEIWCCSEANAFDYFVCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGEVVNLNLLFVLGSIHESIEILGLTHFVSDLERTVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSELLNKHGVILDLCTFVRTKGISPKNSSMIMEVWAKNRASIMQAWFDQKIQIEAQFGINYGENISIYLLSDYEKDNI", "length": 1648 }, "evidence": [ { "id": "A0AAA9SDR2", "url": "https://omabrowser.org/oma/group/A0AAA9SDR2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9Y2E4-1", "protein_name": "Disco-interacting protein 2 homolog C", "gene_name": "DIP2C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPRVDQALPQERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVMAQTHIENHSAPPDVTTYTSEHSIQVERPQGSTGSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYSILHKLGTKQEPMVRPGDRVALVFPNNDPAAFMAAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRTALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYSLMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEIGELCVCAVATGTSYYGLSGMTKNTFEVFPMTSSGAPISEYPFIRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHILYTLLNCRGAIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRTWPLILDTDDLPKKRPAQICKPCNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM", "length": 1556 }, "evidence": [ { "id": "A0AAA9SDR2", "url": "https://omabrowser.org/oma/group/A0AAA9SDR2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1442, "end_pos": 1444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 671, "end_pos": 673, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR2" }, { "id": "PS51912", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51912" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DMAP1-binding", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 176, "start_aa": "Glu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 123 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1442, "end_pos": 1444 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 553, "end_pos": 555 }, { "start_pos": 671, "end_pos": 673 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDR5-1", "uniprot_ac": "A0AAA9SDR5", "uniprot_id": "A0AAA9SDR5_BOVIN", "mass": { "chemical_mass": 50140.0, "monoisotopic_mass": 50140.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Elongation factor 1-alpha", "type": "recommended", "evidence": [ { "id": "A0AAA9SDR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5#function" }, { "database": "UniProtKB", "id": "RU000325", "url": "https://www.uniprot.org/uniprotkb/RU000325#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDR5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01883", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01883", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03693", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03693", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKEKTHINIIVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANKPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHTACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK", "length": 462, "header": "tr|A0AAA9SDR5-1|A0AAA9SDR5_BOVIN Isoform 1 of Elongation factor 1-alpha OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SDR5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5/entry#A0AAA9SDR5-1", "sequence": { "sequence": "MGKEKTHINIIVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANKPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHTACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK", "length": 462, "header": "tr|A0AAA9SDR5-1|A0AAA9SDR5_BOVIN Isoform 1 of Elongation factor 1-alpha OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SDR5-1" }, "locus": { "chromosome": "18", "start_pos": 2915614, "end_pos": 2914878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080511.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR5" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 242, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 314, "end_pos": 316 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDR8-1", "uniprot_ac": "A0AAA9SDR8", "uniprot_id": "A0AAA9SDR8_BOVIN", "mass": { "chemical_mass": 195983.0, "monoisotopic_mass": 195983.0 }, "refseq": {}, "gene_names": [ { "name": "NES", "type": "recommended", "evidence": [ { "id": "A0AAA9SDR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ] } ], "protein_names": [ { "name": "Nestin", "type": "recommended", "evidence": [ { "id": "A0AAA9SDR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA06#function" }, { "database": "UniProtKB", "id": "ARBA00058665", "url": "https://www.uniprot.org/uniprotkb/ARBA00058665#function" }, { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8#function" }, { "database": "UniProtKB", "id": "A0AAA9TV28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV28#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NES", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8", "locus": { "chromosome": "3", "start_pos": 14169368, "end_pos": 14159694, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015794", "url": "https://www.ensembl.org/id/ENSBTAG00000015794" } ] } } ], "crossref": [ { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47051:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47051:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGCLGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQAGDTSWRARADDELAALRALVDQRWREKHAAEVARDNLAEEVEGVASRCQQLRLARERTAEEVARSRRAVEAEKCAQAWLSTQAAELERELEALRVAQEEERAGLNAQAACAPRGSAPPRGPPAPAPEVEELAQRLGEAWRGAVRGYQERVAHMETSLGQARERLGHAMQGAREGRLELQQLQAERSGLQERRAALEQRLEGRWQERLRTTEQFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPASGSKASLSFLDPKLELHFPGTPEGRRPGPLLSVLSPTPLSSPLPGTLETPVPTFLKSQEFLQARTPTSASTPIPPTPQAPCPAVDAEIRAQDAPVSLPQARVGRQQVPEVMWAEAKVAIPASVLPGPEEPGGQQQEPSPSQSPEDHASLAPALSPDHSSLETKDGEPSASRESSRSQEEDEGQLWGLTEKETVVEAKAVSSLQQETCQEEAGLDVKEIQDAQGPLEKEALNSLEEEIQKPSIPLEKQSHETIRSLEKENLESLRSLEEENLETLKILEKENQELLKSLEGKETEVMRSLEKETLELLKPIGKEDPQTLPSLGKENQEIMRSLEVNVETFLYPGKENQELVRSLEEENAESLRTLEKESQEPLRCQEVENQGTLRLLAKDNQEPLRSLEEEDQETSRPLGKENHESLRAPEDENHEALRPLERDKPESLSSLEEDQEAVRPPEREDQELLRSLEKEDQEPLRSLEEDQEAVRPLEEENQELLRSLEKEKEESLRSLEDQEAMRPLEEENQEPLRSLEDQEAMRPLEEENQEPLRSLEKEKQEPLMSLEEDQEEMRALEEDQETVRPLEKEKQESLRSLEDHEAMRPLEEENQEPLRSLEKEKQEVMRPPEEEKQELLRSLEDQEAMRSLEEEGQMTLSPLEKVKPETLKSLGKDQEIVRPLEKENQELLRSLNEKSTEAVRSLETETPEPLKPTEEENLEILKPLEKESQEPLGSVEGNHETLRPPEKENQESLGSLAEWNVENLQSLEEADKGSLRHLEEEEDVEQEESQASLRPLEEQGQELPLSAQQQKWGDAMQGDQELDQERPPGRAGVDSGDGAELELKELDSSPAEGEVVEQGQLQLTATGEAWGPGEGQPGSPEPKEQRLPAEGAGGAGGAAGLQDPEEQPEQVGALGLPAAQGTSEVMEPELEDEDVAPGGGRASPEVTLELERAMGRSEGVERGPEQEAVKLEDPGGLAREEVMEPPLGEGGMAAKKVQGLEGPRKELEEAGTLEPESGKSRDPLETPRDWEESESGALGKTEEPVSAETLWSHEGSDTLQPRPLGSEGAEEDAKPLLGPPSLRPTESCLPSLIPEDAPGPQPLAEGNQEASWGLEGRAEVVGKAGGEQEDLGSGGIPEGLQEEGEESREESEADELGETLPDSTPLGLYLRSPASPKWDLPGEQRPSPQGEPRKEGWDPVVPASKSLGAQPSEEEEEEGAEEEERGHDSELSEEFEDLGTEASLLPGVPGEGEEPLSQVPQLLLEPAAWDRDGESDGFADEEESGEEGEEEDEEEGREPGPGHWGPAPSVGSLPALSGPQGGHLLESETVGVSVPWDDGPRGAAADAPVTALETESQNSTEASGSEEESDAAPLETEDQVPGPLGTLSGVEDTLDGGPGPSLKEELERMNGGVVNGLEQSEGGGQGKPGAAGGDRGSPSEEEGASLKAPWAGAPLHLGQGQFLKFSQREGDGDSWSSGED", "length": 1787, "header": "tr|A0AAA9SDR8-1|A0AAA9SDR8_BOVIN Isoform 1 of Nestin OS=Bos taurus OX=9913 GN=NES PE=3 SV=2 CANONICAL=A0AAA9SDR8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8/entry#A0AAA9SDR8-1", "sequence": { "sequence": "MEGCLGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQAGDTSWRARADDELAALRALVDQRWREKHAAEVARDNLAEEVEGVASRCQQLRLARERTAEEVARSRRAVEAEKCAQAWLSTQAAELERELEALRVAQEEERAGLNAQAACAPRGSAPPRGPPAPAPEVEELAQRLGEAWRGAVRGYQERVAHMETSLGQARERLGHAMQGAREGRLELQQLQAERSGLQERRAALEQRLEGRWQERLRTTEQFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPASGSKASLSFLDPKLELHFPGTPEGRRPGPLLSVLSPTPLSSPLPGTLETPVPTFLKSQEFLQARTPTSASTPIPPTPQAPCPAVDAEIRAQDAPVSLPQARVGRQQVPEVMWAEAKVAIPASVLPGPEEPGGQQQEPSPSQSPEDHASLAPALSPDHSSLETKDGEPSASRESSRSQEEDEGQLWGLTEKETVVEAKAVSSLQQETCQEEAGLDVKEIQDAQGPLEKEALNSLEEEIQKPSIPLEKQSHETIRSLEKENLESLRSLEEENLETLKILEKENQELLKSLEGKETEVMRSLEKETLELLKPIGKEDPQTLPSLGKENQEIMRSLEVNVETFLYPGKENQELVRSLEEENAESLRTLEKESQEPLRCQEVENQGTLRLLAKDNQEPLRSLEEEDQETSRPLGKENHESLRAPEDENHEALRPLERDKPESLSSLEEDQEAVRPPEREDQELLRSLEKEDQEPLRSLEEDQEAVRPLEEENQELLRSLEKEKEESLRSLEDQEAMRPLEEENQEPLRSLEDQEAMRPLEEENQEPLRSLEKEKQEPLMSLEEDQEEMRALEEDQETVRPLEKEKQESLRSLEDHEAMRPLEEENQEPLRSLEKEKQEVMRPPEEEKQELLRSLEDQEAMRSLEEEGQMTLSPLEKVKPETLKSLGKDQEIVRPLEKENQELLRSLNEKSTEAVRSLETETPEPLKPTEEENLEILKPLEKESQEPLGSVEGNHETLRPPEKENQESLGSLAEWNVENLQSLEEADKGSLRHLEEEEDVEQEESQASLRPLEEQGQELPLSAQQQKWGDAMQGDQELDQERPPGRAGVDSGDGAELELKELDSSPAEGEVVEQGQLQLTATGEAWGPGEGQPGSPEPKEQRLPAEGAGGAGGAAGLQDPEEQPEQVGALGLPAAQGTSEVMEPELEDEDVAPGGGRASPEVTLELERAMGRSEGVERGPEQEAVKLEDPGGLAREEVMEPPLGEGGMAAKKVQGLEGPRKELEEAGTLEPESGKSRDPLETPRDWEESESGALGKTEEPVSAETLWSHEGSDTLQPRPLGSEGAEEDAKPLLGPPSLRPTESCLPSLIPEDAPGPQPLAEGNQEASWGLEGRAEVVGKAGGEQEDLGSGGIPEGLQEEGEESREESEADELGETLPDSTPLGLYLRSPASPKWDLPGEQRPSPQGEPRKEGWDPVVPASKSLGAQPSEEEEEEGAEEEERGHDSELSEEFEDLGTEASLLPGVPGEGEEPLSQVPQLLLEPAAWDRDGESDGFADEEESGEEGEEEDEEEGREPGPGHWGPAPSVGSLPALSGPQGGHLLESETVGVSVPWDDGPRGAAADAPVTALETESQNSTEASGSEEESDAAPLETEDQVPGPLGTLSGVEDTLDGGPGPSLKEELERMNGGVVNGLEQSEGGGQGKPGAAGGDRGSPSEEEGASLKAPWAGAPLHLGQGQFLKFSQREGDGDSWSSGED", "length": 1787, "header": "tr|A0AAA9SDR8-1|A0AAA9SDR8_BOVIN Isoform 1 of Nestin OS=Bos taurus OX=9913 GN=NES PE=3 SV=2 CANONICAL=A0AAA9SDR8-1" }, "locus": { "chromosome": "3", "start_pos": 14168364, "end_pos": 14159893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128450.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128450.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081720.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081720.2" } ] } }, { "isoform_ac": "A0AAA9TA06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8/entry#A0AAA9TA06-1", "sequence": { "sequence": "MEGCLGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQAGDTSWRARADDELAALRALVDQRWREKHAAEVARDNLAEEVEGVASRCQQLRLARERTAEEVARSRRAVEAEKCAQAWLSTQAAELERELEALRVAQEEERAGLNAQAACAPRGSAPPRGPPAPAPEVEELAQRLGEAWRGAVRGYQERVAHMETSLGQARERLGHAMQGAREGRLELQQLQAERSGLQERRAALEQRLEGRWQERLRTTEQFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPASGSKASLSFLDPKLELHFPGTPEGRRPGPLLSVLSPTPLSSPLPGTLETPVPTFLKSQEFLQARTPTSASTPIPPTPQAPCPAVDAEIRAQDAPVSLPQARVGRQQVPEVMWAEAKVAIPASVLPGPEEPGGQQQEPSPSQSPEDHASLAPALSPDHSSLETKDGEPSASRESSRSQEEDEGQLWGLTEKETVVEAKAVSSLQQETCQEEAGLDVKEIQDAQGPLEKEALNSLEEEIQKPSIPLEKQSHETIRSLEKENLESLRSLEEENLETLKILEKENQELLKSLEGKETEVMRSLEKETLELLKPIGKEDPQTLPSLGKENQEIMRSLEVNVETFLYPGKENQELVRSLEEENAESLRTLEKESQEPLRCQEVENQGTLRLLAKDNQEPLRSLEEEDQETSRPLGKENHESLRAPEDENHEALRPLERDKPESLSSLEEDQEAVRPPEREDQELLRSLEEDQEAVRPLEEENQELLRSLEKEKEESLRSLEDQEAMRPLEEENQEPLRSLEDHEAMRPLEEENQEPLRSLEKEKQEVMRPPEEEKQELLRSLEDQEAMRSLEEEGQMTLSPLEKVKPETLKSLGKDQEIVRPLEKENQELLRSLNEKSTEAVRSLETETPEPLKPTEEENLEILKPLEKESQEPLGSVEGNHETLRPPEKENQESLGSLAEWNVENLQSLEEADKGSLRHLEEEEDVEQEESQASLRPLEEQGQELPLSAQQQKWGDAMQGDQELDQERPPGRAGVDSGDGAELELKELDSSPAEGEVVEQGQLQLTATGEAWGPGEGQPGSPEPKEQRLPAEGAGGAGGAAGLQDPEEQPEQVGALGLPAAQGTSEVMEPELEDEDVAPGGGRASPEVTLELERAMGRSEGVERGPEQEAVKLEDPGGLAREEVMEPPLGEGGMAAKKVQGLEGPRKELEEAGTLEPESGKSRDPLETPRDWEESESGALGKTEEPVSAETLWSHEGSDTLQPRPLGSEGAEEDAKPLLGPPSLRPTESCLPSLIPEDAPGPQPLAEGNQEASWGLEGRAEVVGKAGGEQEDLGSGGIPEGLQEEGEESREESEADELGETLPDSTPLGLYLRSPASPKWDLPGEQRPSPQGEPRKEGWDPVVPASKSLGAQPSEEEEEEGAEEEERGHDSELSEEFEDLGTEASLLPGVPGEGEEPLSQVPQLLLEPAAWDRDGESDGFADEEESGEEGEEEDEEEGREPGPGHWGPAPSVGSLPALSGPQGGHLLESETVGVSVPWDDGPRGAAADAPVTALETESQNSTEASGSEEESDAAPLETEDQVPGPLGTLSGVEDTLDGGPGPSLKEELERMNGGVVNGLEQSEGGGQGKPGAAGGDRGSPSEEEGASLKAPWAGAPLHLGQGQFLKFSQREGDGDSWSSGED", "length": 1714, "header": "tr|A0AAA9TA06-1|A0AAA9TA06_BOVIN Computationally mapped isoform of Nestin OS=Bos taurus OX=9913 GN=NES PE=3 SV=1 CANONICAL=A0AAA9SDR8-1" }, "locus": { "chromosome": "3", "start_pos": 14168364, "end_pos": 14159893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106115.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106115.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092768.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092768.1" } ] } }, { "isoform_ac": "A0AAA9TV28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8/entry#A0AAA9TV28-1", "sequence": { "sequence": "MEGCLGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQAGDTSWRARADDELAALRALVDQRWREKHAAEVARDNLAEEVEELAQRLGEAWRGAVRGYQERVAHMETSLGQARERLGHAMQGAREGRLELQQLQAERSGLQERRAALEQRLEGRWQERLRTTEQFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPASGSKASLSFLDPKLELHFPGTPEGRRPGPLLSVLSPTPLSSPLPGTLETPVPTFLKSQEFLQARTPTSASTPIPPTPQAPCPAVDAEIRAQDAPVSLPQARVGRQQVPEVMWAEAKVAIPASVLPGPEEPGGQQQEPSPSQSPEDHASLAPALSPDHSSLETKDGEPSASRESSRSQEEDEGQLWGLTEKETVVEAKAVSSLQQETCQEEAGLDVKEIQDAQGPLEKEALNSLEEEIQKPSIPLEKQSHETIRSLEKENLESLRSLEEENLETLKILEKENQELLKSLEGKETEVMRSLEKETLELLKPIGKEDPQTLPSLGKENQEIMRSLEVNVETFLYPGKENQELVRSLEEENAESLRTLEKESQEPLRCQEVENQGTLRLLAKDNQEPLRSLEEEDQETSRPLGKENHESLRAPEDENHEALRPLERDKPESLSSLEEDQEAVRPPEREDQELLRSLEKEDQEPLRSLEEDQEAVRPLEEENQELLRSLEKEKQEATRPPEEEKQEPLMSLEEDQEEMRALEEDQETVRPLEKEKQESLRSLEDHEAMRPLEEENQEPLRSLEKEKQEVMRPPEEEKQELLRSLEDQEAMRSLEEEGQMTLSPLEKVKPETLKSLGKDQEIVRPLEKENQELLRSLNEKSTEAVRSLETETPEPLKPTEEENLEILKPLEKESQEPLGSVEGNHETLRPPEKENQESLGSLAEWNVENLQSLEEADKGSLRHLEEEEDVEQEESQASLRPLEEQGQELPLSAQQQKWGDAMQGDQELDQERPPGRAGVDSGDGAELELKELDSSPAEGEVVEQGQLQLTATGEAWGPGEGQPGSPEPKEQRLPAEGAGGAGGAAGLQDPEEQPEQVGALGLPAAQGTSEVMEPELEDEDVAPGGGRASPEVTLELERAMGRSEGVERGPEQEAVKLEDPGGLAREEVMEPPLGEGGMAAKKVQGLEGPRKELEEAGTLEPESGKSRDPLETPRDWEESESGALGKTEEPVSAETLWSHEGSDTLQPRPLGSEGAEEDAKPLLGPPSLRPTESCLPSLIPEDAPGPQPLAEGNQEASWGLEGRAEVVGKAGGEQEDLGSGGIPEGLQEEGEESREESEADELGETLPDSTPLGLYLRSPASPKWDLPGEQRPSPQGEPRKEGWDPVVPASKSLGAQPSEEEEEEGAEEEERGHDSELSEEFEDLGTEASLLPGVPGEGEEPLSQVPQLLLEPAAWDRDGESDGFADEEESGEEGEEEDEEEGREPGPGHWGPAPSVGSLPALSGPQGGHLLESETVGVSVPWDDGPRGAAADAPVTALETESQNSTEASGSEEESDAAPLETEDQVPGPLGTLSGVEDTLDGGPGPSLKEELERMNGGVVNGLEQSEGGGQGKPGAAGGDRGSPSEEEGASLKAPWAGAPLHLGQGQFLKFSQREGDGDSWSSGED", "length": 1660, "header": "tr|A0AAA9TV28-1|A0AAA9TV28_BOVIN Computationally mapped isoform of Nestin OS=Bos taurus OX=9913 GN=NES PE=3 SV=1 CANONICAL=A0AAA9SDR8-1" }, "locus": { "chromosome": "3", "start_pos": 14168364, "end_pos": 14159893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121402.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121402.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102471.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102471.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 393, "start_aa": "Thr", "end_pos": 393, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr393", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G2/M transition of mitotic cell cycle", "id": "GO:0000086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ], "pmid": "" }, { "name": "stem cell proliferation", "id": "GO:0072089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072089", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "intermediate filament binding", "id": "GO:0019215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019215", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1665, "end_pos": 1667, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR8" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 313, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 393 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1665, "end_pos": 1667 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDU2-1", "uniprot_ac": "A0AAA9SDU2", "uniprot_id": "A0AAA9SDU2_BOVIN", "mass": { "chemical_mass": 11246.0, "monoisotopic_mass": 11246.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SDU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDU2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07699", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07699", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GQPKSPPSVTLFPPSKEELSANKATLVCLISDFYPGSVTVAWKADGSTITRNVETTRASKQSNSKYAASSYLSLTSSDWKSKGSYSCEVTHEGSTVTKTVKTSACS", "length": 106, "header": "tr|A0AAA9SDU2-1|A0AAA9SDU2_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SDU2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2/entry#A0AAA9SDU2-1", "sequence": { "sequence": "GQPKSPPSVTLFPPSKEELSANKATLVCLISDFYPGSVTVAWKADGSTITRNVETTRASKQSNSKYAASSYLSLTSSDWKSKGSYSCEVTHEGSTVTKTVKTSACS", "length": 106, "header": "tr|A0AAA9SDU2-1|A0AAA9SDU2_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SDU2-1" }, "locus": { "chromosome": "17", "start_pos": 71131370, "end_pos": 71131053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087897.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087897.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081752.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 103, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDU6-1", "uniprot_ac": "A0AAA9SDU6", "uniprot_id": "A0AAA9SDU6_BOVIN", "mass": { "chemical_mass": 41425.0, "monoisotopic_mass": 41425.0 }, "refseq": {}, "gene_names": [ { "name": "ISL2", "type": "recommended", "evidence": [ { "id": "A0AAA9SDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ] } ], "protein_names": [ { "name": "Insulin gene enhancer protein ISL-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6#function" }, { "database": "UniProtKB", "id": "ARBA00055727", "url": "https://www.uniprot.org/uniprotkb/ARBA00055727#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ISL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6", "locus": { "chromosome": "21", "start_pos": 31590381, "end_pos": 31584333, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016651", "url": "https://www.ensembl.org/id/ENSBTAG00000016651" } ] } } ], "crossref": [ { "id": "A0AAA9SDU6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09366", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09366", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09471", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09471", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24204", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24204", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24204:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24204:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVDIIFHYPFLGTMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDPGSGRQPSLRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHNDKTSLQGLTGTPLVAGSPIRHESAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVRTCSALPEGWTPGEVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET", "length": 374, "header": "tr|A0AAA9SDU6-1|A0AAA9SDU6_BOVIN Isoform 1 of Insulin gene enhancer protein ISL-2 OS=Bos taurus OX=9913 GN=ISL2 PE=4 SV=1 CANONICAL=A0AAA9SDU6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6/entry#A0AAA9SDU6-1", "sequence": { "sequence": "MVDIIFHYPFLGTMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDPGSGRQPSLRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHNDKTSLQGLTGTPLVAGSPIRHESAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVRTCSALPEGWTPGEVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET", "length": 374, "header": "tr|A0AAA9SDU6-1|A0AAA9SDU6_BOVIN Isoform 1 of Insulin gene enhancer protein ISL-2 OS=Bos taurus OX=9913 GN=ISL2 PE=4 SV=1 CANONICAL=A0AAA9SDU6-1" }, "locus": { "chromosome": "21", "start_pos": 31589549, "end_pos": 31584548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125097.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125097.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083566.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 333, "start_aa": "Thr", "end_pos": 333, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr333", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" }, { "name": "neuron fate specification", "id": "GO:0048665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048665", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 249, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU6" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 87, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 333 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 347, "end_pos": 349 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDW0-1", "uniprot_ac": "A0AAA9SDW0", "uniprot_id": "A0AAA9SDW0_BOVIN", "mass": { "chemical_mass": 41219.0, "monoisotopic_mass": 41219.0 }, "refseq": {}, "gene_names": [ { "name": "PRRT2", "type": "recommended", "evidence": [ { "id": "A0AAA9SDW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ] } ], "protein_names": [ { "name": "PAXIP1 associated glutamate rich protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SDW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRRT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDW0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "112444325", "url": "https://www.ncbi.nlm.nih.gov/gene/112444325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14948", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14948", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14948:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14948:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFK3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZFK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2W2", "url": "https://www.uniprot.org/uniprotkb/G3N2W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2W2-1", "url": "https://www.uniprot.org/uniprotkb/G3N2W2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASSSEVSEIKGVEEGPQTQGEGPGHSEGRTGSPQVPAGVSDEPETLQPAPDVMGAPGDSEPKVGLAPETTETPTGVPEAAQARNLSSSPGGEAKANSSTEETCQELASKPEVRKEATADPESNLESAAPLEPASEPAPQPEPQPEPQPASQSTSTPALQPEPPAQEEPTSEILSESMGEKQENGAVVPLQAGDGDGEEGLAPQPHSPPSTKTPPANGAPPRVLQQLVEEDRLGKAHSGHSGSPRGSLSRHPSSQLAGSGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGILIIIASCVINLGGPDDPQGASGSQSWQARPRLETCRGGVFRTRTWENGGARLLTLPGQPELTCPIWAF", "length": 399, "header": "tr|A0AAA9SDW0-1|A0AAA9SDW0_BOVIN Isoform 1 of PAXIP1 associated glutamate rich protein 1 OS=Bos taurus OX=9913 GN=PRRT2 PE=3 SV=1 CANONICAL=A0AAA9SDW0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0/entry#A0AAA9SDW0-1", "sequence": { "sequence": "MAASSSEVSEIKGVEEGPQTQGEGPGHSEGRTGSPQVPAGVSDEPETLQPAPDVMGAPGDSEPKVGLAPETTETPTGVPEAAQARNLSSSPGGEAKANSSTEETCQELASKPEVRKEATADPESNLESAAPLEPASEPAPQPEPQPEPQPASQSTSTPALQPEPPAQEEPTSEILSESMGEKQENGAVVPLQAGDGDGEEGLAPQPHSPPSTKTPPANGAPPRVLQQLVEEDRLGKAHSGHSGSPRGSLSRHPSSQLAGSGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGILIIIASCVINLGGPDDPQGASGSQSWQARPRLETCRGGVFRTRTWENGGARLLTLPGQPELTCPIWAF", "length": 399, "header": "tr|A0AAA9SDW0-1|A0AAA9SDW0_BOVIN Isoform 1 of PAXIP1 associated glutamate rich protein 1 OS=Bos taurus OX=9913 GN=PRRT2 PE=3 SV=1 CANONICAL=A0AAA9SDW0-1" }, "locus": { "chromosome": "25", "start_pos": 26430674, "end_pos": 26428253, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111520.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111520.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080561.1" } ] } }, { "isoform_ac": "A0AAA9SGP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0/entry#A0AAA9SGP3-1", "sequence": { "sequence": "MSHPKAKETPTFLPFPQRQPKAGPETGASLSWAAALKATSSLLTPSLSPPLAGFAAVFSAVPSFPQRPSPLSCLKMAASSSEVSEIKGVEEGPQTQGEGPGHSEGRTGSPQVPAGVSDEPETLQPAPDVMGAPGDSEPKVGLAPETTETPTGVPEAAQARNLSSSPGGEAKANSSTEETCQELASKPEVRKEATADPESNLESAAPLEPASEPAPQPEPQPEPQPASQSTSTPALQPEPPAQEEPTSEILSESMGEKQENGAVVPLQAGDGDGEEGLAPQPHSPPSTKTPPANGAPPRVLQQLVEEDRLGKAHSGHSGSPRGSLSRHPSSQLAGSGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMVSPREPCLARACSGSQFPALCWDTAPGVTPPPLPSLHGSHFPITGPLLTSPWDFTF", "length": 430, "header": "tr|A0AAA9SGP3-1|A0AAA9SGP3_BOVIN Computationally mapped isoform of PAXIP1 associated glutamate rich protein 1 OS=Bos taurus OX=9913 GN=PRRT2 PE=3 SV=1 CANONICAL=A0AAA9SDW0-1" }, "locus": { "chromosome": "25", "start_pos": 26423821, "end_pos": 26423668, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014478.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014478.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014478.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014478.3" } ] } }, { "isoform_ac": "A0AAA9TQS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0/entry#A0AAA9TQS6-1", "sequence": { "sequence": "MSHPKAKETPTFLPFPQRQPKAGPETGASLSWAAALKATSSLLTPSLSPPLAGFAAVFSAVPSFPQRPSPLSCLKMAASSSEVSEIKGVEEGPQTQGEGPGHSEGRTGSPQVPAGVSDEPETLQPAPDVMGAPGDSEPKVGLAPETTETPTGVPEAAQARNLSSSPGGEAKANSSTEETCQELASKPEVRKEATADPESNLESAAPLEPASEPAPQPEPQPEPQPASQSTSTPALQPEPPAQEEPTSEILSESMGEKQENGAVVPLQAGDGDGEEGLAPQPHSPPSTKTPPANGAPPRVLQQLVEEDRLGKAHSGHSGSPRGSLSRHPSSQLAGSGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGILIIIASCVINLGGPDDPQGASGSQSWQARPRLETCRGGVFRTRTWENGGARLLTLPGQPELTCPIWAF", "length": 474, "header": "tr|A0AAA9TQS6-1|A0AAA9TQS6_BOVIN Computationally mapped isoform of PAXIP1 associated glutamate rich protein 1 OS=Bos taurus OX=9913 GN=PRRT2 PE=3 SV=1 CANONICAL=A0AAA9SDW0-1" }, "locus": { "chromosome": "25", "start_pos": 26430899, "end_pos": 26428253, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128999.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128999.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099665.1" } ] } }, { "isoform_ac": "A0AAF6ZFK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0/entry#A0AAF6ZFK3-1", "sequence": { "sequence": "MAASSSEVSEIKGVEEGPQTQGEGPGHSEGRTGSPQVPAGVSDEPETLQPAPDVMGAPGDSEPKVGLAPETTETPTGVPEAAQARNLSSSPGGEAKANSSTEETCQELASKPEVRKEATADPESNLESAAPLEPASEPAPQPEPQPEPQPASQSTSTPALQPEPPAQEEPTSEILSESMGEKQENGAVVPLQAGDGDGEEGLAPQPHSPPSTKTPPANGAPPRVLQQLVEEDRLGKAHSGHSGSPRGSLSRHPSSQLAGSGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGILIIIASCVINLGVYK", "length": 346, "header": "tr|A0AAF6ZFK3-1|A0AAF6ZFK3_BOVIN Computationally mapped isoform of PAXIP1 associated glutamate rich protein 1 OS=Bos taurus OX=9913 GN=PRRT2 PE=3 SV=1 CANONICAL=A0AAA9SDW0-1" }, "locus": { "chromosome": "25", "start_pos": 26430674, "end_pos": 26429083, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045230.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045230.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042638.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042638.4" } ] } }, { "isoform_ac": "G3N2W2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0/entry#G3N2W2-1", "sequence": { "sequence": "MAASSSEVSEIKGVEEGPQTQGEGPGHSEGRTGSPQVPAGVSDEPETLQPAPDVMGAPGDSEPKVGLAPETTETPTGVPEAAQARNLSSSPGGEAKANSSTEETCQELASKPEVRKEATADPESNLESAAPLEPASEPAPQPEPQPEPQPASQSTSTPALQPEPPAQEEPTSEILSESMGEKQENGAVVPLQAGDGDGEEGLAPQPHSPPSTKTPPANGAPPRVLQQLVEEDRLGKAHSGHSGSPRGSLSRHPSSQLAGSGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGILIIIASCVINLGGEWGSGTGGGMEGLARAALLTPAPALSCLSSLLLCLSLSPPTPVCPSLSSPTVYK", "length": 398, "header": "tr|G3N2W2-1|G3N2W2_BOVIN Computationally mapped isoform of PAXIP1 associated glutamate rich protein 1 OS=Bos taurus OX=9913 GN=PRRT2 PE=3 SV=3 CANONICAL=A0AAA9SDW0-1" }, "locus": { "chromosome": "25", "start_pos": 26430674, "end_pos": 26429083, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064339.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064339.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056232.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056232.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of SNARE complex assembly", "id": "GO:0035544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035544", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "synaptic vesicle fusion to presynaptic active zone membrane", "id": "GO:0031629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "negative regulation of short-term synaptic potentiation", "id": "GO:1905513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" }, { "name": "regulation of calcium-dependent activation of synaptic vesicle fusion", "id": "GO:0150037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "syntaxin-1 binding", "id": "GO:0017075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017075", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 86, "end_pos": 88 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDW1-1", "uniprot_ac": "A0AAA9SDW1", "uniprot_id": "A0AAA9SDW1_BOVIN", "mass": { "chemical_mass": 75290.0, "monoisotopic_mass": 75290.0 }, "refseq": {}, "gene_names": [ { "name": "ANOS1", "type": "recommended", "evidence": [ { "id": "A0AAA9SDW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1" } ] } ], "protein_names": [ { "name": "Anosmin 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SDW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANOS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1", "locus": { "chromosome": "X", "start_pos": 134432566, "end_pos": 134225187, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069639", "url": "https://www.ensembl.org/id/ENSBTAG00000069639" } ] } } ], "crossref": [ { "id": "A0AAA9SDW1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDW1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00199", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00199", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525898", "url": "https://www.ncbi.nlm.nih.gov/gene/525898", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525898", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525898", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14131:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14131:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00095", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00095", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17869", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17869", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28407", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28407", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228592", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228592", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGAPGAALTLCLWLAASAGCLAAGSGAAAARRLDESLAAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKVSWDLRKQQCQSFCESLFPKKNYECVTSCEFLKYILSVKQGDCPSPEKASGFAAACVESCDADDECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNVSIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDVRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLVNSTVHSDGSVAVTIAWDVPEEPDIPVHHYKVFWSWTVNGKSLVPTKKKRRKTTDGSQNSVTLEPLQLGCDYTVELQAITYWGQTRLKSAKVSLQFTSAHAAHNKEQLGKSRKSVMHTQPPLQRRRPARLLEVGAPFFQDNQLQVKVYWKKTEDPGIGQYHVEWFPEVCTHNESARLEASSAVTQENYMILLDLSFSCKYKVIVQAARPQGRWKAESASFTTPPCSALKGKAHKHFSCPGAEESHSPVHPKMQAKPENLSASFMVHDANITGHFSWRVNQAGLPRPATGFQVTWAEVTTESRPNSLPNSIISQSQILPADHPELSVPGLRPATLYRLEVQVLTAGGEGPATIRTFRTPDVHGPHLKHHHPHHYKPPAERY", "length": 678, "header": "tr|A0AAA9SDW1-1|A0AAA9SDW1_BOVIN Isoform 1 of Anosmin 1 OS=Bos taurus OX=9913 GN=ANOS1 PE=4 SV=2 CANONICAL=A0AAA9SDW1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1/entry#A0AAA9SDW1-1", "sequence": { "sequence": "MAAGAPGAALTLCLWLAASAGCLAAGSGAAAARRLDESLAAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKVSWDLRKQQCQSFCESLFPKKNYECVTSCEFLKYILSVKQGDCPSPEKASGFAAACVESCDADDECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNVSIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDVRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLVNSTVHSDGSVAVTIAWDVPEEPDIPVHHYKVFWSWTVNGKSLVPTKKKRRKTTDGSQNSVTLEPLQLGCDYTVELQAITYWGQTRLKSAKVSLQFTSAHAAHNKEQLGKSRKSVMHTQPPLQRRRPARLLEVGAPFFQDNQLQVKVYWKKTEDPGIGQYHVEWFPEVCTHNESARLEASSAVTQENYMILLDLSFSCKYKVIVQAARPQGRWKAESASFTTPPCSALKGKAHKHFSCPGAEESHSPVHPKMQAKPENLSASFMVHDANITGHFSWRVNQAGLPRPATGFQVTWAEVTTESRPNSLPNSIISQSQILPADHPELSVPGLRPATLYRLEVQVLTAGGEGPATIRTFRTPDVHGPHLKHHHPHHYKPPAERY", "length": 678, "header": "tr|A0AAA9SDW1-1|A0AAA9SDW1_BOVIN Isoform 1 of Anosmin 1 OS=Bos taurus OX=9913 GN=ANOS1 PE=4 SV=2 CANONICAL=A0AAA9SDW1-1" }, "locus": { "chromosome": "Y", "start_pos": 5895520, "end_pos": 5689332, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104943.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104943.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081775.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081775.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525898", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525898", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 287, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW1" }, { "id": "PS51390", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51390" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WAP", "eco_id": "ECO_0000259", "start_pos": 127, "end_pos": 176, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 209, "end_pos": 211 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 470, "end_pos": 472 }, { "start_pos": 556, "end_pos": 558 }, { "start_pos": 567, "end_pos": 569 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDW9-1", "uniprot_ac": "A0AAA9SDW9", "uniprot_id": "A0AAA9SDW9_BOVIN", "mass": { "chemical_mass": 207030.0, "monoisotopic_mass": 207030.0 }, "refseq": { "ac": "XP_024841837", "name": "TATA-binding protein-associated factor 172 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841837" }, "gene_names": [ { "name": "BTAF1", "type": "recommended", "evidence": [ { "id": "A0AAA9SDW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ] }, { "name": "BTAF1", "type": "synonym", "evidence": [ { "id": "XP_024841837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841837" } ] } ], "protein_names": [ { "name": "B-TFIID TATA-box binding protein associated factor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SDW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9/entry#names_and_taxonomy" } ] }, { "name": "TATA-binding protein-associated factor 172 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024841837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841837" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTAF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9", "locus": { "chromosome": "26", "start_pos": 13541914, "end_pos": 13454613, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016104", "url": "https://www.ensembl.org/id/ENSBTAG00000016104" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016104", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016104", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17999", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17999", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18793", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18793", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523664", "url": "https://www.ncbi.nlm.nih.gov/gene/523664", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022707", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022707", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523664", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523664", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR36498", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36498", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36498:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36498:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12054", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12054", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841837", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841837", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N507", "url": "https://www.uniprot.org/uniprotkb/F1N507", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N507-1", "url": "https://www.uniprot.org/uniprotkb/F1N507-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVSRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSTNWDTRIAAGQAVEAIVKNVPEWNPVPRTKQETTSESAMEDSSTTDRLNFDRFDICRLLQHGASLLGSAGAEFEVQDEKSGEVDPKERIARQRKLLQKKLGLNMGEAIGMSTEELFNDEDLDYTPTSAALVNKQPTLQAAELIDSEFRTGMSNRQKNKAKRMAKLFAKQRSRDAVETNEKSNDSTDGEPEEKRRKTSNVVINQSAVDSKVLIDNIPDSSPLIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLTQEQWEVRHGGLLGIKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQTQKVPFIINTLWDALLELDDLTASTNSIMTLLSSLLTYPQVQQCSIQQSLTVLVPRVWPFLHHTISSVRRAALETLFTLLSTQDQNSSSWLTPILPDMLRHIFQFCVLESSQEILDLIHKVWMELLSKASVQYVVAAACPWMAAWLCLMMQPSHLPIDLNMLLEVKARAKEKTGGKVRQGQSQSKVLQEYIAGADTVMEDPTTRDFVVMRARMMAAKLLGALCCCICDPSVNVVTQEIKPAESLGQLLLFHLNSKSALQRISVALVICEWAALQKECRAVTLAVQPRLLDTLSEHLYYDEIAIPFTRMQNECKQLISSLADAHIEVGNRVNNNVFTIDQANDLVTTVFNEVTSSFNLNPQVLQQLDSKRQQVQMTVTETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQWMAKLLQQCTTRTPCPNSKIIKNLCSSLCVDPYLTPSVTCPVPTQSGQENSKGSNSEKDGMHHTVTKHRGIITLYRHQKAAFAITSRRGPTPKAVKAQIADLPAGGSGNLLVELDEAQKPYLVQRRGAEFALTTIVKHFGGEMAVKLPHLWDAMVGPLRNTIDIHNFDGKSLLEKGDGPAQELVNSLQVFETAAVSMDSELHPLLVLHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMNIFLEKVLPWLGAIDDNIKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSEELIQLKAKERHFLEQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCHRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPPTERIRLQHQVKRHNLVVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSAALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEFKNTTEKLAAQNSSLHDIQHAPKLSALKQLLLDCGLGNGSTSESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLDKDGKAEKADTSTSGKTSMRSILENLSDLWDQEQYDSEYSLENFMHSLK", "length": 1848, "header": "tr|A0AAA9SDW9-1|A0AAA9SDW9_BOVIN Isoform 1 of B-TFIID TATA-box binding protein associated factor 1 OS=Bos taurus OX=9913 GN=BTAF1 PE=4 SV=1 CANONICAL=A0AAA9SDW9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9/entry#A0AAA9SDW9-1", "sequence": { "sequence": "MAVSRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSTNWDTRIAAGQAVEAIVKNVPEWNPVPRTKQETTSESAMEDSSTTDRLNFDRFDICRLLQHGASLLGSAGAEFEVQDEKSGEVDPKERIARQRKLLQKKLGLNMGEAIGMSTEELFNDEDLDYTPTSAALVNKQPTLQAAELIDSEFRTGMSNRQKNKAKRMAKLFAKQRSRDAVETNEKSNDSTDGEPEEKRRKTSNVVINQSAVDSKVLIDNIPDSSPLIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLTQEQWEVRHGGLLGIKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQTQKVPFIINTLWDALLELDDLTASTNSIMTLLSSLLTYPQVQQCSIQQSLTVLVPRVWPFLHHTISSVRRAALETLFTLLSTQDQNSSSWLTPILPDMLRHIFQFCVLESSQEILDLIHKVWMELLSKASVQYVVAAACPWMAAWLCLMMQPSHLPIDLNMLLEVKARAKEKTGGKVRQGQSQSKVLQEYIAGADTVMEDPTTRDFVVMRARMMAAKLLGALCCCICDPSVNVVTQEIKPAESLGQLLLFHLNSKSALQRISVALVICEWAALQKECRAVTLAVQPRLLDTLSEHLYYDEIAIPFTRMQNECKQLISSLADAHIEVGNRVNNNVFTIDQANDLVTTVFNEVTSSFNLNPQVLQQLDSKRQQVQMTVTETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQWMAKLLQQCTTRTPCPNSKIIKNLCSSLCVDPYLTPSVTCPVPTQSGQENSKGSNSEKDGMHHTVTKHRGIITLYRHQKAAFAITSRRGPTPKAVKAQIADLPAGGSGNLLVELDEAQKPYLVQRRGAEFALTTIVKHFGGEMAVKLPHLWDAMVGPLRNTIDIHNFDGKSLLEKGDGPAQELVNSLQVFETAAVSMDSELHPLLVLHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMNIFLEKVLPWLGAIDDNIKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSEELIQLKAKERHFLEQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCHRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPPTERIRLQHQVKRHNLVVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSAALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEFKNTTEKLAAQNSSLHDIQHAPKLSALKQLLLDCGLGNGSTSESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLDKDGKAEKADTSTSGKTSMRSILENLSDLWDQEQYDSEYSLENFMHSLK", "length": 1848, "header": "tr|A0AAA9SDW9-1|A0AAA9SDW9_BOVIN Isoform 1 of B-TFIID TATA-box binding protein associated factor 1 OS=Bos taurus OX=9913 GN=BTAF1 PE=4 SV=1 CANONICAL=A0AAA9SDW9-1" }, "locus": { "chromosome": "26", "start_pos": 13540910, "end_pos": 13454812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130859.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130859.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080571.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080571.1" } ] } }, { "isoform_ac": "F1N507-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9/entry#F1N507-1", "sequence": { "sequence": "MFLMDFCEVDPKERIARQRKLLQKKLGLNMGEAIGMSTEELFNDEDLDYTPTSAALVNKQPTLQAAELIDSEFRTGMSNRQKNKAKRMAKLFAKQRSRDAVETNEKSNDSTDGEPEEKRRKTSNVVINQSAVDSKVLIDNIPDSSPLIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQQHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLTQEQWEVRHGGLLGIKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQTQKVPFIINTLWDALLELDDLTASTNSIMTLLSSLLTYPQVQQCSIQQSLTVLVPRVWPFLHHTISSVRRAALETLFTLLSTQDQNSSSWLTPILPDMLRHIFQFCVLESSQEILDLIHKVWMELLSKASVQYVVAAACPWMAAWLCLMMQPSHLPIDLNMLLEVKARAKEKTGGKVRQGQSQSKVLQEYIAGADTVMEDPTTRDFVVMRARMMAAKLLGALCCCICDPSVNVVTQEIKPAESLGQLLLFHLNSKSALQRISVALVICEWAALQKECRAVTLAVQPRLLDTLSEHLYYDEIAIPFTRMQNECKQLISSLADAHIEVGNRVNNNVFTIDQANDLVTTVFNEVTSSFNLNPQVLQQLDSKRQQVQMTVTETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQWMAKLLQQCTTRTPCPNSKIIKNLCSSLCVDPYLTPSVTCPVPTQSGQENSKGSNSEKDGMHHTVTKHRGIITLYRHQKAAFAITSRRGPTPKAVKAQIADLPAGGSGNLLVELDEAQKPYLVQRRGAEFALTTIVKHFGGEMAVKLPHLWDAMVGPLRNTIDIHNFDGKSLLEKGDGPAQELVNSLQVFETAAVSMDSELHPLLVLHLPHLYMCLQYPSTAVRHMAARCVGVMSKIATMETMNIFLEKVLPWLGAIDDNIKQEGAIEALACVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSEELIQLKAKERHFLEQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCHRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPPTERIRLQHQVKRHNLVVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSAALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLTPQHPEFKNTTEKLAAQNSSLHDIQHAPKLSALKQLLLDCGLGNGSTSESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLDKDGKAEKADTSTSGKTSMRSILENLSDLWDQEQYDSEYSLENFMHSLK", "length": 1721, "header": "tr|F1N507-1|F1N507_BOVIN Computationally mapped isoform of B-TFIID TATA-box binding protein associated factor 1 OS=Bos taurus OX=9913 GN=BTAF1 PE=4 SV=4 CANONICAL=A0AAA9SDW9-1" }, "locus": { "chromosome": "26", "start_pos": 13540910, "end_pos": 13477592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021438.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021438.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021438.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021438.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523664", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523664", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "TBP-class protein binding", "id": "GO:0017025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "ATP-dependent activity, acting on DNA", "id": "GO:0008094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1227, "end_pos": 1229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1594, "end_pos": 1596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1603, "end_pos": 1605, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1629, "end_pos": 1631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1713, "end_pos": 1715, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1782, "end_pos": 1784, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1824, "end_pos": 1826, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 1277, "end_pos": 1452, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SDW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW9" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 1635, "end_pos": 1789, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1227, "end_pos": 1229 }, { "start_pos": 1594, "end_pos": 1596 }, { "start_pos": 1603, "end_pos": 1605 }, { "start_pos": 1629, "end_pos": 1631 }, { "start_pos": 1713, "end_pos": 1715 }, { "start_pos": 1782, "end_pos": 1784 }, { "start_pos": 1824, "end_pos": 1826 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 255, "end_pos": 257 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 551, "end_pos": 553 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDY5-1", "uniprot_ac": "A0AAA9SDY5", "uniprot_id": "A0AAA9SDY5_BOVIN", "mass": { "chemical_mass": 66508.0, "monoisotopic_mass": 66508.0 }, "refseq": {}, "gene_names": [ { "name": "LOC786996", "type": "recommended", "evidence": [ { "id": "A0AAA9SDY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5" } ] } ], "protein_names": [ { "name": "GP-PDE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SDY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC786996", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SDY5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23344:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23344:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDDINRTEVGNEETGRRENNSWIKRHFNYECYMTFLNGCYSCKWEAQQKKKPRHALCCCSLRERIFYPWLIMSFFLSTILLFTWVETSNEYNGFDWVVFLGARIWFFWSLVLLSVIGILAAYTTMLVVLGFLLCWEKNELYLHWYHKIMVLIVILLCSFLMWILLTFWRERWLTIGLSLQVFAPYIHLSSISAMVLLSWPVAFYLIHLEGEARMRRYQNTSERRRNKWCTMLTKLRVLQVVVGLPFLLILLCLYVVPFGTYSPCVQEKDKLAPKPDFFGHRGAPMLGPENTIMSFEKAVEQGAHGLESDVQISLDEVPFLMHDYDLRRTTNILEVMPNASDEQSNFFYWDFLSTLNAGKWFIKPFFGMKPLSEADRERARNQKIPKLSELLEIARKAKKKVIFDLYTPPRSHPSRSSYIRLVVSVILDSKIEQHLIIWLPGSERDYVRSKAPGFQHIGRLFTIERLTKEKITRINVDYKNLFYNGLKEYKAANITINVYLVNEPWLFSLAWCSSIHSVTTDNIQVLKEINHPYYFMVSWLSRLFFQLLKSRDLCDIEDVAFPLL", "length": 564, "header": "tr|A0AAA9SDY5-1|A0AAA9SDY5_BOVIN Isoform 1 of GP-PDE domain-containing protein OS=Bos taurus OX=9913 GN=LOC786996 PE=3 SV=1 CANONICAL=A0AAA9SDY5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5/entry#A0AAA9SDY5-1", "sequence": { "sequence": "MDDINRTEVGNEETGRRENNSWIKRHFNYECYMTFLNGCYSCKWEAQQKKKPRHALCCCSLRERIFYPWLIMSFFLSTILLFTWVETSNEYNGFDWVVFLGARIWFFWSLVLLSVIGILAAYTTMLVVLGFLLCWEKNELYLHWYHKIMVLIVILLCSFLMWILLTFWRERWLTIGLSLQVFAPYIHLSSISAMVLLSWPVAFYLIHLEGEARMRRYQNTSERRRNKWCTMLTKLRVLQVVVGLPFLLILLCLYVVPFGTYSPCVQEKDKLAPKPDFFGHRGAPMLGPENTIMSFEKAVEQGAHGLESDVQISLDEVPFLMHDYDLRRTTNILEVMPNASDEQSNFFYWDFLSTLNAGKWFIKPFFGMKPLSEADRERARNQKIPKLSELLEIARKAKKKVIFDLYTPPRSHPSRSSYIRLVVSVILDSKIEQHLIIWLPGSERDYVRSKAPGFQHIGRLFTIERLTKEKITRINVDYKNLFYNGLKEYKAANITINVYLVNEPWLFSLAWCSSIHSVTTDNIQVLKEINHPYYFMVSWLSRLFFQLLKSRDLCDIEDVAFPLL", "length": 564, "header": "tr|A0AAA9SDY5-1|A0AAA9SDY5_BOVIN Isoform 1 of GP-PDE domain-containing protein OS=Bos taurus OX=9913 GN=LOC786996 PE=3 SV=1 CANONICAL=A0AAA9SDY5-1" }, "locus": { "chromosome": "15", "start_pos": 56742955, "end_pos": 56655982, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118671.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118671.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082026.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphoric diester hydrolase activity", "id": "GO:0008081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008081", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY5" }, { "id": "PS51704", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51704" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GP-PDE", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 530, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 219, "end_pos": 221 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 493, "end_pos": 495 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDZ4-1", "uniprot_ac": "A0AAA9SDZ4", "uniprot_id": "A0AAA9SDZ4_BOVIN", "mass": { "chemical_mass": 123519.0, "monoisotopic_mass": 123519.0 }, "refseq": {}, "gene_names": [ { "name": "SYNE3", "type": "recommended", "evidence": [ { "id": "A0AAA9SDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ] } ], "protein_names": [ { "name": "Nesprin-3", "type": "recommended", "evidence": [ { "id": "A0AAA9SDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#names_and_taxonomy" } ] }, { "name": "KASH domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#names_and_taxonomy" } ] }, { "name": "Nuclear envelope spectrin repeat protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BJU6", "url": "https://www.uniprot.org/uniprotkb/E1BJU6#function" }, { "database": "UniProtKB", "id": "ARBA00058355", "url": "https://www.uniprot.org/uniprotkb/ARBA00058355#function" }, { "database": "UniProtKB", "id": "A0A3Q1MN88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN88#function" }, { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4", "locus": { "chromosome": "21", "start_pos": 60271216, "end_pos": 60380333, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003526", "url": "https://www.ensembl.org/id/ENSBTAG00000003526" } ] } } ], "crossref": [ { "id": "A0AAA9SDZ4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003526", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003526", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR012315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MN88", "url": "https://www.orthodb.org/?gene=A0A3Q1MN88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BJU6", "url": "https://www.orthodb.org/?gene=E1BJU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47535", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47535", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47535:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47535:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25803", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25803", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25804", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25804", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MN88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJU6", "url": "https://www.uniprot.org/uniprotkb/E1BJU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTALSSPLPPGKGVCEGSRRAEAGPRGPPPSARIAALFFLARPAASAGPWGRLAWRVRRGLGGAGASARAPPRPRPAPEPPGTQGGGRWLGPDCPRRRAPASSRPAPAGAMTQQPQEGFDRSVEDARRWMRAVQERLQINDNTQGPRTALEARLRETEKICQLEPEGRVKVDVVLQAAEALLACCHEDQKTEILARLRDIKAQWEETVTHMVHCHSRIEWVWLHWSEYLLARDEFYRWFQKMTVALAPPVELQSSLKEKQWQLSHAQVLLRNADHQAVLLDRLLEEAASLFNRIGDPSVDEDAQQRMKAEYDAVKAKAQDRVDFLEQVTREHECFQASVDEFQLWLKAVVERVDGCMGRKCRLSTQDRLLALQGIANDFPKGEESLKRLEEQAVGVTQNTSPLGAEKITRDLEEMRDVLEKLRGLWEEEQGRLRDLVKSKGACEQQRGQLEAELTEFRKDLQRLAEEGLGTTAKAATEDELVARWRLYLATREALATEEPRVDRLQAQLKELIVSLQDPKPLSDSVVAAIQEYQRMKAKSSRLRNAAATELWQRFQRHPQDLQLWRELAQRLLDVTASLPDPPSIHTFLPQIEAALTESSRLKEQLTMLQLKKDLLGSIFGQERATALLEEVATSVRDRDLLHNRLLQRKSKLQSLLAQHKDFGATFEPLQKKLSDLQIRVQAENGLRRDLPEKQAQLLRLQGLQEEEMDLGSQVEAMRPLFQGNPNHQHKMDQLSAAHQALQRSLEDLLEGRQQSLREHCTFNHELLKLRHWISVITQKLEAHRGDTGPWDAQSQETEVERLLAEFPEKEAQLLEMEALGRLVMEASSLEGAALVQGELEELTESWRALRQLEESLLSLTRNRQLQRMTEVDSGKKMIFTNNIPKTGFLILPTDLTSRHRRQAGLLQGQGGSHEDYSQSLRNFEDWLQEENSKLVRIIAMKTATAEDLRTRATKLQELEARIPEGQHLFENLLRLRPASESSDELEDLRYRWMLYKSKLKDSSHLLTQSPLGEPTGFRKAARWRGLSSLCRKVCCVALPLQLLLLLFLLLLFLLPVGEENRSCFLANNFARSLTLMLRYDGPPPT", "length": 1086, "header": "tr|A0AAA9SDZ4-1|A0AAA9SDZ4_BOVIN Isoform 1 of Nesprin-3 OS=Bos taurus OX=9913 GN=SYNE3 PE=3 SV=1 CANONICAL=A0AAA9SDZ4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MN88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#A0A3Q1MN88-1", "sequence": { "sequence": "MTQQPQEGFDRSVEDARRWMRAVQERLQINDNTQGPRTALEARLRETEKICQLEPEGRVKVDVVLQAAEALLACCHEDQKTEILARLRDIKAQWEETVTHMVHCHSRIEWVWLHWSEYLLARDEFYRWFQKMTVALAPPVELQSSLKEKQWQLSHAQVLLRNADHQAVLLDRLLEEAASLFNRIGDPSVDEDAQQRMKAEYDAVKAKAQDRVDFLEQVTREHECFQASVDEFQLWLKAVVERVDGCMGRKCRLSTQDRLLALQGIANDFPKGEESLKRLEEQAVGVTQNTSPLGAEKITRDLEEMRDVLEKLRGLWEEEQGRLRDLVKSKGACEQQRGQLEAELTEFRKDLQRLAEEGLGTTAKAATEDELVARWRLYLATREALATEEPRVDRLQAQLKELIVSLQDPKPLSDSVVAAIQEYQRMKAKSSRLRNAAATELWQRFQRHPQDLQLWRELAQRLLDVTASLPDPPSIHTFLPQIEAALTESSRLKEQLTMLQLKKDLLGSIFGQERATALLEEVATSVRDRDLLHNRLLQRKSKLQSLLAQHKDFGATFEPLQKKLSDLQIRVQAENGLRRDLPEKQAQLLRLQGLQEEEMDLGSQVEAMRPLFQGNPNHQHKMDQLSAAHQALQRSLEDLLEGRQQSLREHCTFNHELLKLRHWISVITQKLEAHRGDTGPWDAQSQETEVERLLAEFPEKEAQLLEMEALGRLVMEASSLEGAALVQGELEELTESWRALRQLEESLLSLTRNRQLQRMTEVDSGKKMIFTNNIPKTGFLILPTDLTSRHRRQAGLLQGQGGSHEDYSQSLRNFEDWLQEENSKLVRIIAMKTATAEDLRTRATKLQTQSPLGEPTGFRKAARWRGLSSLCRKVCCVALPLQLLLLLFLLLLFLLPVGEENRSCFLANNFARSLTLMLRYDGPPPT", "length": 926, "header": "tr|A0A3Q1MN88-1|A0A3Q1MN88_BOVIN Computationally mapped isoform of Nesprin-3 OS=Bos taurus OX=9913 GN=SYNE3 PE=3 SV=2 CANONICAL=A0AAA9SDZ4-1" }, "locus": { "chromosome": "21", "start_pos": 60332709, "end_pos": 60273430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084195.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084195.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072699.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072699.2" } ] } }, { "isoform_ac": "A0AAA9SDZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#A0AAA9SDZ4-1", "sequence": { "sequence": "MTALSSPLPPGKGVCEGSRRAEAGPRGPPPSARIAALFFLARPAASAGPWGRLAWRVRRGLGGAGASARAPPRPRPAPEPPGTQGGGRWLGPDCPRRRAPASSRPAPAGAMTQQPQEGFDRSVEDARRWMRAVQERLQINDNTQGPRTALEARLRETEKICQLEPEGRVKVDVVLQAAEALLACCHEDQKTEILARLRDIKAQWEETVTHMVHCHSRIEWVWLHWSEYLLARDEFYRWFQKMTVALAPPVELQSSLKEKQWQLSHAQVLLRNADHQAVLLDRLLEEAASLFNRIGDPSVDEDAQQRMKAEYDAVKAKAQDRVDFLEQVTREHECFQASVDEFQLWLKAVVERVDGCMGRKCRLSTQDRLLALQGIANDFPKGEESLKRLEEQAVGVTQNTSPLGAEKITRDLEEMRDVLEKLRGLWEEEQGRLRDLVKSKGACEQQRGQLEAELTEFRKDLQRLAEEGLGTTAKAATEDELVARWRLYLATREALATEEPRVDRLQAQLKELIVSLQDPKPLSDSVVAAIQEYQRMKAKSSRLRNAAATELWQRFQRHPQDLQLWRELAQRLLDVTASLPDPPSIHTFLPQIEAALTESSRLKEQLTMLQLKKDLLGSIFGQERATALLEEVATSVRDRDLLHNRLLQRKSKLQSLLAQHKDFGATFEPLQKKLSDLQIRVQAENGLRRDLPEKQAQLLRLQGLQEEEMDLGSQVEAMRPLFQGNPNHQHKMDQLSAAHQALQRSLEDLLEGRQQSLREHCTFNHELLKLRHWISVITQKLEAHRGDTGPWDAQSQETEVERLLAEFPEKEAQLLEMEALGRLVMEASSLEGAALVQGELEELTESWRALRQLEESLLSLTRNRQLQRMTEVDSGKKMIFTNNIPKTGFLILPTDLTSRHRRQAGLLQGQGGSHEDYSQSLRNFEDWLQEENSKLVRIIAMKTATAEDLRTRATKLQELEARIPEGQHLFENLLRLRPASESSDELEDLRYRWMLYKSKLKDSSHLLTQSPLGEPTGFRKAARWRGLSSLCRKVCCVALPLQLLLLLFLLLLFLLPVGEENRSCFLANNFARSLTLMLRYDGPPPT", "length": 1086, "header": "tr|A0AAA9SDZ4-1|A0AAA9SDZ4_BOVIN Isoform 1 of Nesprin-3 OS=Bos taurus OX=9913 GN=SYNE3 PE=3 SV=1 CANONICAL=A0AAA9SDZ4-1" }, "locus": { "chromosome": "21", "start_pos": 60380134, "end_pos": 60273430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095697.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095697.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082036.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082036.1" } ] } }, { "isoform_ac": "A0AAA9SSA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#A0AAA9SSA0-1", "sequence": { "sequence": "MTALSSPLPPGKGVCEGSRRAEAGPRGPPPSARIAALFFLARPAASAGPWGRLAWRVRRGLGGAGASARAPPRPRPAPEPPGTQGGGRWLGPDCPRRRAPASSRPAPAGAMTQQPQEGFDRSVEDARRWMRAVQERLQINDNTQGPRTALEARLRETEKICQLEPEGRVKVDVVLQAAEALLACCHEDQKTEILARLRDIKAQWEETVTHMVHCHSRIEWVWLHWSEYLLARDEFYRWFQKMTVALAPPVELQSSLKEKQWQLSHAQVLLRNADHQAVLLDRLLEEAASLFNRIGDPSVDEDAQQRMKAEYDAVKAKAQDRVDFLEQVTREHECFQASVDEFQLWLKAVVERVDGCMGRKCRLSTQDRLLALQGIANDFPKGEESLKRLEEQAVGVTQNTSPLGAEKITRDLEEMRDVLEKLRGLWEEEQGRLRDLVKSKGACEQQRGQLEAELTEFRKDLQRLAEEGLGTTAKAATEDELVARWRLYLATREALATEEPRVDRLQAQLKELIVSLQDPKPLSDSVVAAIQEYQRMKAKSSRLRNAAATELWQRFQRHPQDLQLWRELAQRLLDVTASLPDPPSIHTFLPQIEAALTESSRLKEQLTMLQLKKDLLGSIFGQERATALLEEVATSVRDRDLLHNRLLQRKSKLQSLLAQHKDFGATFEPLQKKLSDLQIRVQAENGLRRDLPEKQAQLLRLQDLLEGRQQSLREHCTFNHELLKLRHWISVITQKLEAHRGDTGPWDAQSQETEVERLLAEFPEKEAQLLEMEALGRLVMEASSLEGAALVQGELEELTESWRALRQLEESLLSLTRNRQLQRMTEVDSGKKMIFTNNIPKTGFLILPTDLTSRHRRQAGLLQGQGGSHEDYSQSLRNFEDWLQEENSKLVRIIAMKTATAEDLRTRATKLQELEARIPEGQHLFENLLRLRPASESSDELEDLRYRWMLYKSKLKDSSHLLTQSPLGEPTGFRKAARWRGLSSLCRKVCCVALPLQLLLLLFLLLLFLLPVGEENRSCFLANNFARSLTLMLRYDGPPPT", "length": 1041, "header": "tr|A0AAA9SSA0-1|A0AAA9SSA0_BOVIN Computationally mapped isoform of Spectrin repeat containing nuclear envelope family member 3 OS=Bos taurus OX=9913 GN=SYNE3 PE=3 SV=1 CANONICAL=A0AAA9SDZ4-1" }, "locus": { "chromosome": "21", "start_pos": 60380134, "end_pos": 60273430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119733.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119733.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085893.1" } ] } }, { "isoform_ac": "E1BJU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4/entry#E1BJU6-1", "sequence": { "sequence": "MTALSSPLPPGKGVCEGSRRAEAGPRGPPPSARIAALFFLARPAASAGPWGRLAWRVRRGLGGAGASARAPPRPRPAPEPPGTQGGGRWLGPDCPRRRAPASSRPAPAGAMTQQPQEGFDRSVEDARRWMRAVQERLQINDNTQGPRTALEARLRETEKICQLEPEGRVKVDVVLQAAEALLACCHEDQKTEILARLRDIKAQWEETVTHMVHCHSRIEWVWLHWSEYLLARDEFYRWFQKMTVALAPPVELQSSLKEKQWQLSHAQVLLRNADHQAVLLDRLLEEAASLFNRIGDPSVDEDAQQRMKAEYDAVKAKAQDRVDFLEQVTREHECFQASVDEFQLWLKAVVERVDGCMGRKCRLSTQDRLLALQGIANDFPKGEESLKRLEEQAVGVTQNTSPLGAEKITRDLEEMRDVLEKLRGLWEEEQGRLRDLVKSKGACEQQRGQLEAELTEFRKDLQRLAEEGLGTTAKAATEDELVARWRLYLATREALATEEPRVDRLQAQLKELIVSLQDPKPLSDSVVAAIQEYQRMKAKSSRLRNAAATELWQRFQRHPQDLQLWRELAQRLLDVTASLPDPPSIHTFLPQIEAALTESSRLKEQLTMLQLKKDLLGSIFGQERATALLEEVATSVRDRDLLHNRLLQRKSKLQSLLAQHKDFGATFEPLQKKLSDLQIRVQAENGLRRDLPEKQAQLLRLQGLQEEEMDLGSQVEAMRPLFQGNPNHQHKMDQLSAAHQALQRSLEDLLEGRQQSLREHCTFNHELLKLRHWISVITQKLEAHRGDTGPWDAQSQETEVERLLAEFPEKEAQLLEMEALGRLVMEASSLEGAALVQGELEELTESWRALRQLEESLLSLTRNRQLQRMTEVDSGKKMIFTNNIPKTGFLILPTDLTSRHRRQELEARIPEGQHLFENLLRLRPASESSDELEDLRYRWMLYKSKLKDSSHLLTQSPLGEPTGFRKAARWRGLSSLCRKVCCVALPLQLLLLLFLLLLFLLPVGEENRSCFLANNFARSLTLMLRYDGPPPT", "length": 1032, "header": "tr|E1BJU6-1|E1BJU6_BOVIN Computationally mapped isoform of Nesprin-3 OS=Bos taurus OX=9913 GN=SYNE3 PE=3 SV=3 CANONICAL=A0AAA9SDZ4-1" }, "locus": { "chromosome": "21", "start_pos": 60380134, "end_pos": 60273430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004584.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004584.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004584.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004584.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "rough endoplasmic reticulum", "id": "GO:0005791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "nuclear outer membrane", "id": "GO:0005640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005640", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "meiotic nuclear membrane microtubule tethering complex", "id": "GO:0034993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "cytoskeleton-nuclear membrane anchor activity", "id": "GO:0140444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "establishment of protein localization to membrane", "id": "GO:0090150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090150", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" }, { "name": "nuclear migration", "id": "GO:0007097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007097", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ4" }, { "id": "PS51049", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51049" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KASH", "eco_id": "ECO_0000259", "start_pos": 1028, "end_pos": 1086, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 399, "end_pos": 401 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE28-1", "uniprot_ac": "A0AAA9SE28", "uniprot_id": "A0AAA9SE28_BOVIN", "mass": { "chemical_mass": 80905.0, "monoisotopic_mass": 80905.0 }, "refseq": {}, "gene_names": [ { "name": "SCFD2", "type": "recommended", "evidence": [ { "id": "A0AAA9SE28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28" } ] } ], "protein_names": [ { "name": "Sec1 family domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SE28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCFD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28", "locus": { "chromosome": "6", "start_pos": 68538960, "end_pos": 68936132, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020648", "url": "https://www.ensembl.org/id/ENSBTAG00000020648" } ] } } ], "crossref": [ { "id": "A0AAA9SE28", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE28", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001619", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001619", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11679", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11679", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00995", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00995", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SE28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RQA7", "url": "https://www.uniprot.org/uniprotkb/F6RQA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RQA7-1", "url": "https://www.uniprot.org/uniprotkb/F6RQA7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTPGVLSFTQQAWEQVLAKAKRAVVYLDAACAESLHWGCGSSRLLEAVGSPACYLREFEPAAVGGGVEQPKAVFVLSSLLKGRIVETLRDIICRSHFQYCVVVTAVNHAVHLTANHVPAAAAAELEGQQPVFEQLEEKLCEWMGNMNYTAEVLHIPLLLAPVAPHLALTPAFASLFPLLPQDVHILNSARPDRRRLGSLAEVDATALTPELLLQIRCLVSGLSSLCEHLGVREECFAVGALSRIIAADLANFAPAKNRRKTATGRASVVFVDRTLDLTGAVGHHGDNLVEKILAVLPQLPGHTNDVMVNMVELTALQDEEENQNVVVPGCLAQSNDPAAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSVGRVTPGQLMSYIQLFKNNLKSLGNHCGLLQLGLATVQTLKHPQTAKWDNFLAFERLLLQNIGESTMSVVLNQLLPMIKPLNQRTSDDYSPEELLVLLLYIYSVGGEFSVDKDLGEGEEKVKKALAQVFCEESELSPLLRKITGCDSSINLTFHKSKSAVDELFTLLRDIAGARNLMKQFKSVYVPGNHTHQASYKPLLKQVVEEIFNPERPDPVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDHPLLILFVVGGVTVSEAKMIKDLVLSLKPGTQLCAGSVCCQQPSVTWRQQNRDASAVLRVGCRLRRELSTITAQNPGGIPTMPGCPPPALGERYRCLLLPPTQPAKELLSPLASQTAH", "length": 740, "header": "tr|A0AAA9SE28-1|A0AAA9SE28_BOVIN Isoform 1 of Sec1 family domain containing 2 OS=Bos taurus OX=9913 GN=SCFD2 PE=3 SV=1 CANONICAL=A0AAA9SE28-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28/entry#A0AAA9SE28-1", "sequence": { "sequence": "MNTPGVLSFTQQAWEQVLAKAKRAVVYLDAACAESLHWGCGSSRLLEAVGSPACYLREFEPAAVGGGVEQPKAVFVLSSLLKGRIVETLRDIICRSHFQYCVVVTAVNHAVHLTANHVPAAAAAELEGQQPVFEQLEEKLCEWMGNMNYTAEVLHIPLLLAPVAPHLALTPAFASLFPLLPQDVHILNSARPDRRRLGSLAEVDATALTPELLLQIRCLVSGLSSLCEHLGVREECFAVGALSRIIAADLANFAPAKNRRKTATGRASVVFVDRTLDLTGAVGHHGDNLVEKILAVLPQLPGHTNDVMVNMVELTALQDEEENQNVVVPGCLAQSNDPAAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSVGRVTPGQLMSYIQLFKNNLKSLGNHCGLLQLGLATVQTLKHPQTAKWDNFLAFERLLLQNIGESTMSVVLNQLLPMIKPLNQRTSDDYSPEELLVLLLYIYSVGGEFSVDKDLGEGEEKVKKALAQVFCEESELSPLLRKITGCDSSINLTFHKSKSAVDELFTLLRDIAGARNLMKQFKSVYVPGNHTHQASYKPLLKQVVEEIFNPERPDPVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDHPLLILFVVGGVTVSEAKMIKDLVLSLKPGTQLCAGSVCCQQPSVTWRQQNRDASAVLRVGCRLRRELSTITAQNPGGIPTMPGCPPPALGERYRCLLLPPTQPAKELLSPLASQTAH", "length": 740, "header": "tr|A0AAA9SE28-1|A0AAA9SE28_BOVIN Isoform 1 of Sec1 family domain containing 2 OS=Bos taurus OX=9913 GN=SCFD2 PE=3 SV=1 CANONICAL=A0AAA9SE28-1" }, "locus": { "chromosome": "6", "start_pos": 68935933, "end_pos": 68550011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106762.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106762.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083657.1" } ] } }, { "isoform_ac": "A0AAA9TCA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28/entry#A0AAA9TCA4-1", "sequence": { "sequence": "MNTPGVLSFTQQAWEQVLAKAKRAVVYLDAACAESLHWGCGSSRLLEAVGSPACYLREFEPAAVGGGVEQPKAVFVLSSLLKGRIVETLRDIICRSHFQYCVVVTAVNHAVHLTANHVPAAAAAELEGQQPVFEQLEEKLCEWMGNMNYTAEDVHILNSARPDRRRLGSLAEVDATALTPELLLQIRCLVSGLSSLCEHLGVREECFAVGALSRIIAADLANFAPAKNRRKTATGRASVVFVDRTLDLTGAVGHHGDNLVEKILAVLPQLPGHTNDVMVNMVELTALQDEEENQNVVVPGCLAQSNDPAAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSVGRVTPGQLMSYIQLFKNNLKSLGNHCGLLQLGLATVQTLKHPQTAKWDNFLAFERLLLQNIGESTMSVVLNQLLPMIKPLNQRTSDDYSPEELLVLLLYIYSVGGEFSVDKDLGEGEEKVKKALAQVFCEESELSPLLRKITGCDSSINLTFHKSKSAVDELFTLLRDIAGARNLMKQFKSVYVPGNHTHQASYKPLLKQVVEEIFNPERPDPVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDHPLLILFVVGGVTVSEAKMIKDLVLSLKPGTQVIVLSTRLLKPLNIPELLFATDRLHPDLGF", "length": 654, "header": "tr|A0AAA9TCA4-1|A0AAA9TCA4_BOVIN Computationally mapped isoform of Sec1 family domain containing 2 OS=Bos taurus OX=9913 GN=SCFD2 PE=3 SV=1 CANONICAL=A0AAA9SE28-1" }, "locus": { "chromosome": "6", "start_pos": 68935933, "end_pos": 68540404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117730.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117730.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096298.1" } ] } }, { "isoform_ac": "A0AAA9TSM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28/entry#A0AAA9TSM0-1", "sequence": { "sequence": "MNTPGVLSFTQQAWEQVLAKAKRAVVYLDAACAESLHWGCGSSRLLEAVGSPACYLREFEPAAVGGGVEQPKAVFVLSSLLKGRIVETLRDIICRSHFQYCVVVTAVNHAVHLTANHVPAAAAAELEGQQPVFEQLEEKLCEWMGNMNYTAEVLHIPLLLAPVAPHLALTPAFASLFPLLPQDVHILNSARPDRRRLGSLAEVDATALTPELLLQIRCLVSGLSSLCEHLGVREECFAVGALSRIIAADLANFAPAKNRRKTATGRASVVFVDRTLDLTGAVGHHGDNLVEKILAVLPQLPGHTNDVMVNMVELTALQDEEENQNVVVPGCLAQSNDPAAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSVGRVTPGQLMSYIQLFKNNLKSLGNHCGLLQLGLATVQTLKHPQTAKWDNFLAFERLLLQNIGESTMSVVLNQLLPMIKPLNQRTSDDYSPEELLVLLLYIYSVGGEFSVDKDLGEGEEKVKKALAQVFCEESELSPLLRKITGCDSSINLTFHKSKSAVDELFTLLRDIAGARNLMKQFKSVYVPGNHTHQASYKPLLKQVVEEIFNPERPDPVDIEHMSSGLTDLLKTGFSMFMKMLPS", "length": 618, "header": "tr|A0AAA9TSM0-1|A0AAA9TSM0_BOVIN Computationally mapped isoform of Sec1 family domain containing 2 OS=Bos taurus OX=9913 GN=SCFD2 PE=3 SV=1 CANONICAL=A0AAA9SE28-1" }, "locus": { "chromosome": "6", "start_pos": 68935933, "end_pos": 68567150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108903.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108903.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099476.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099476.1" } ] } }, { "isoform_ac": "F6RQA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28/entry#F6RQA7-1", "sequence": { "sequence": "MNTPGVLSFTQQAWEQVLAKAKRAVVYLDAACAESLHWGCGSSRLLEAVGSPACYLREFEPAAVGGGVEQPKAVFVLSSLLKGRIVETLRDIICRSHFQYCVVVTAVNHAVHLTANHVPAAAAAELEGQQPVFEQLEEKLCEWMGNMNYTAEVLHIPLLLAPVAPHLALTPAFASLFPLLPQDVHILNSARPDRRRLGSLAEVDATALTPELLLQIRCLVSGLSSLCEHLGVREECFAVGALSRIIAADLANFAPAKNRRKTATGRASVVFVDRTLDLTGAVGHHGDNLVEKILAVLPQLPGHTNDVMVNMVELTALQDEEENQNVVVPGCLAQSNDPAAKALWEALLNTKHKEAVMEVRRHLVEAASRENLPIKMSVGRVTPGQLMSYIQLFKNNLKSLGNHCGLLQLGLATVQTLKHPQTAKWDNFLAFERLLLQNIGESTMSVVLNQLLPMIKPLNQRTSDDYSPEELLVLLLYIYSVGGEFSVDKDLGEGEEKVKKALAQVFCEESELSPLLRKITGCDSSINLTFHKSKSAVDELFTLLRDIAGARNLMKQFKSVYVPGNHTHQVSRPHPSDHPLLILFVVGGVTVSEAKMIKDLVLSLKPGTQVIVLSTRLLKPLNIPELLFATDRLHPDLGF", "length": 639, "header": "tr|F6RQA7-1|F6RQA7_BOVIN Computationally mapped isoform of Sec1 family domain containing 2 OS=Bos taurus OX=9913 GN=SCFD2 PE=3 SV=1 CANONICAL=A0AAA9SE28-1" }, "locus": { "chromosome": "6", "start_pos": 68935933, "end_pos": 68540404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027519.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027519.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027519.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027519.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 382, "start_aa": "Thr", "end_pos": 382, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr382", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 527, "end_pos": 529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 382 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 148, "end_pos": 150 }, { "start_pos": 527, "end_pos": 529 }, { "start_pos": 565, "end_pos": 567 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE47-1", "uniprot_ac": "A0AAA9SE47", "uniprot_id": "A0AAA9SE47_BOVIN", "mass": { "chemical_mass": 42479.0, "monoisotopic_mass": 42479.0 }, "refseq": {}, "gene_names": [ { "name": "SLC10A7", "type": "recommended", "evidence": [ { "id": "A0AAA9SE47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ] } ], "protein_names": [ { "name": "Sodium/bile acid cotransporter", "type": "recommended", "evidence": [ { "id": "A0AAA9SE47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Does not show transport activity towards bile acids or steroid sulfates.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47#function" }, { "database": "UniProtKB", "id": "PIRNR026166", "url": "https://www.uniprot.org/uniprotkb/PIRNR026166#function" }, { "database": "UniProtKB", "id": "A0AAA9TJB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJB7#function" }, { "database": "UniProtKB", "id": "A0A3Q1MUE9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE9#function" }, { "database": "UniProtKB", "id": "G5E6T4", "url": "https://www.uniprot.org/uniprotkb/G5E6T4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC10A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47", "locus": { "chromosome": "17", "start_pos": 12090565, "end_pos": 11769151, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034522", "url": "https://www.ensembl.org/id/ENSBTAG00000034522" } ] } } ], "crossref": [ { "id": "A0AAA9SE47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034522", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034522", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613859", "url": "https://www.ncbi.nlm.nih.gov/gene/613859", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUE9", "url": "https://www.orthodb.org/?gene=A0A3Q1MUE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G5E6T4", "url": "https://www.orthodb.org/?gene=G5E6T4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18640:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18640:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13593", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13593", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MUE9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QEH9", "url": "https://www.uniprot.org/uniprotkb/F6QEH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QEH9-1", "url": "https://www.uniprot.org/uniprotkb/F6QEH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E6T4", "url": "https://www.uniprot.org/uniprotkb/G5E6T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E6T4-1", "url": "https://www.uniprot.org/uniprotkb/G5E6T4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEELTSALVHIKLHLFIQIFTLAFFPAAVWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLLWILDPKCHTFCLPFSILNVSLPAGFSLCFHHLWQRTISRVEMGIVVTPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKQPPFGAVSSSVLLMIIYTTFCDTFSNPSIDLDKFSLLLVLFIICSIQLSFMLLTFIYSTRNNSGFTPADTVAVMFCSTHKSLTLGIPMLKIVFAGHEYLSLISVPLLIYHPVQILLGSVLVPTIKSWMVSRQKGVKLMRPTV", "length": 383, "header": "tr|A0AAA9SE47-1|A0AAA9SE47_BOVIN Isoform 1 of Sodium/bile acid cotransporter OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=1 CANONICAL=A0AAA9SE47-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#A0A3Q1MUE9-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEELTSALVHIKLHLFIQIFTLAFFPAAVWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEGIVVTPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKQPPFGAVSSSVLLMIIYTTFCDTFSNPSIDLDKFSLLLVLFIICSIQLSFMLLTFIYSTRNNSGFTPADTVAVMFCSTHKSLTLGIPMLKIVFAGHEYLSLISVPLLIYHPVQILLGSVLVPTIKSWMVSRQKGVKLMRPTV", "length": 327, "header": "tr|A0A3Q1MUE9-1|A0A3Q1MUE9_BOVIN Computationally mapped isoform of Sodium/bile acid cotransporter OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=2 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 12089561, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066896.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066896.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074186.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074186.2" } ] } }, { "isoform_ac": "A0AAA9SE47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#A0AAA9SE47-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEELTSALVHIKLHLFIQIFTLAFFPAAVWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLLWILDPKCHTFCLPFSILNVSLPAGFSLCFHHLWQRTISRVEMGIVVTPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKQPPFGAVSSSVLLMIIYTTFCDTFSNPSIDLDKFSLLLVLFIICSIQLSFMLLTFIYSTRNNSGFTPADTVAVMFCSTHKSLTLGIPMLKIVFAGHEYLSLISVPLLIYHPVQILLGSVLVPTIKSWMVSRQKGVKLMRPTV", "length": 383, "header": "tr|A0AAA9SE47-1|A0AAA9SE47_BOVIN Isoform 1 of Sodium/bile acid cotransporter OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=1 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 12089561, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087618.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087618.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081863.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081863.1" } ] } }, { "isoform_ac": "A0AAA9SEG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#A0AAA9SEG7-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEVADSRLHASACVFCGDINQSSWWK", "length": 85, "header": "tr|A0AAA9SEG7-1|A0AAA9SEG7_BOVIN Computationally mapped isoform of Solute carrier family 10 member 7 OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=2 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 11796313, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094540.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094540.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081987.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081987.2" } ] } }, { "isoform_ac": "A0AAA9SRC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#A0AAA9SRC9-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEFLA", "length": 64, "header": "tr|A0AAA9SRC9-1|A0AAA9SRC9_BOVIN Computationally mapped isoform of Solute carrier family 10 member 7 OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=2 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 11778691, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092888.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092888.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086533.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086533.2" } ] } }, { "isoform_ac": "A0AAA9TJB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#A0AAA9TJB7-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEELTSALVHIKLHLFIQIFTLAFFPAAVWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVVTPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKQPPFGAVSSSVLLMIIYTTFCDTFSNPSIDLDKFSLLLVLFIICSIQLSFMLLTFIYSTRNNSGFTPADTVAVMFCSTHKSLTLGIPMLKIVFAGHEYLSLISVPLLIYHPVQILLGSVLVPTIKSWMVSRQKKPLQTRRSPANVDHPEVLKYLAIPSGHK", "length": 359, "header": "tr|A0AAA9TJB7-1|A0AAA9TJB7_BOVIN Computationally mapped isoform of Sodium/bile acid cotransporter OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=1 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 12089209, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098549.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098549.1" } ] } }, { "isoform_ac": "F6QEH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#F6QEH9-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEELTSALVHIKLHLFIQIFTLAFFPAAVWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLVSKHDLICLLLLL", "length": 158, "header": "tr|F6QEH9-1|F6QEH9_BOVIN Computationally mapped isoform of Solute carrier family 10 member 7 OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=2 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 11880104, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048906.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048906.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045867.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045867.3" } ] } }, { "isoform_ac": "G5E6T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47/entry#G5E6T4-1", "sequence": { "sequence": "MRLLERMRKEWFMIGIVLAIAGAKLEPSIGMNGGPLKPEITVSYIAVATIFFNSGLSLNTEELTSALVHIKLHLFIQIFTLAFFPAAVWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVVTPLLLLLFIVRRYIKDWLERKQPPFGAVSSSVLLMIIYTTFCDTFSNPSIDLDKFSLLLVLFIICSIQLSFMLLTFIYSTRNNSGFTPADTVAVMFCSTHKSLTLGIPMLKIVFAGHEYLSLISVPLLIYHPVQILLGSVLVPTIKSWMVSRQKGVKLMRPTV", "length": 312, "header": "tr|G5E6T4-1|G5E6T4_BOVIN Computationally mapped isoform of Sodium/bile acid cotransporter OS=Bos taurus OX=9913 GN=SLC10A7 PE=3 SV=2 CANONICAL=A0AAA9SE47-1" }, "locus": { "chromosome": "17", "start_pos": 12089561, "end_pos": 11769315, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064876.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064876.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056497.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056497.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" }, { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" }, { "name": "heparin proteoglycan biosynthetic process", "id": "GO:0030210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030210", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 302, "end_pos": 304 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE69-1", "uniprot_ac": "A0AAA9SE69", "uniprot_id": "A0AAA9SE69_BOVIN", "mass": { "chemical_mass": 61157.0, "monoisotopic_mass": 61157.0 }, "refseq": { "ac": "NP_001179780", "name": "iduronate 2-sulfatase precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179780" }, "gene_names": [ { "name": "IDS", "type": "recommended", "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ] }, { "name": "IDS", "type": "synonym", "evidence": [ { "id": "NP_001179780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179780" } ] } ], "protein_names": [ { "name": "Iduronate 2-sulfatase", "type": "recommended", "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69/entry#names_and_taxonomy" } ] }, { "name": "3.1.6.13", "type": "synonym", "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69/entry#names_and_taxonomy" } ] }, { "name": "Alpha-L-iduronate sulfate sulfatase", "type": "synonym", "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69/entry#names_and_taxonomy" } ] }, { "name": "iduronate 2-sulfatase (Hunter syndrome)", "type": "synonym", "evidence": [ { "id": "NP_001179780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179780" } ] }, { "name": "iduronate 2-sulfatase precursor", "type": "synonym", "evidence": [ { "id": "NP_001179780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179780" } ] } ], "function": [ { "annotation": "Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.", "evidence": [ { "database": "UniProtKB", "id": "F1N2D5", "url": "https://www.uniprot.org/uniprotkb/F1N2D5#function" }, { "database": "UniProtKB", "id": "ARBA00056350", "url": "https://www.uniprot.org/uniprotkb/ARBA00056350#function" }, { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IDS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69", "locus": { "chromosome": "X", "start_pos": 31987339, "end_pos": 32006608, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011056", "url": "https://www.ensembl.org/id/ENSBTAG00000011056" } ] } } ], "crossref": [ { "id": "A0AAA9SE69", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE69", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011056", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011056", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541272", "url": "https://www.ncbi.nlm.nih.gov/gene/541272", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541272", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541272", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVFTRAY", "url": "https://omabrowser.org/oma/group/HVFTRAY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2D5", "url": "https://www.orthodb.org/?gene=F1N2D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45953", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45953", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45953:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45953:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024096", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2024101", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024101", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179780", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2D5", "url": "https://www.uniprot.org/uniprotkb/F1N2D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2D5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPPSRSLLWLGLVLGAVCASRGPAAPGNATDPLNVLLIIVDDLRPSLGCYGNKLIRSPNIDQLASRSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDSPYSWSVPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVVDVPEGTLPDKQSTEQAIQLLGKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENVSLAPDPQVPTGLPLVAYNPWMDLRQREDIQALNLSVPYGPIPADFQRKIRQSYFACVSYLDTQVGRLLSALDDLQLASSTIVAFTSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGRTAPLPVEGEKFFPYLDPFDSVSEVPEPGRQTGDLVELLSLFPTLAGLAGLRVPPRCPIPSFHMELCREGRNLLKLFEDHGEEEEPHVRSNPRELVAYSQYPRPADSPQWNSDKPSLEDIKVMGYSIRTVDYRYTVWVGFNPQEFLANFSDIHAGELYFVASDPLQDHNVYNDSQGGTLPQSFMP", "length": 547, "header": "tr|A0AAA9SE69-1|A0AAA9SE69_BOVIN Isoform 1 of Iduronate 2-sulfatase OS=Bos taurus OX=9913 GN=IDS PE=3 SV=1 CANONICAL=A0AAA9SE69-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69/entry#A0AAA9SE69-1", "sequence": { "sequence": "MPPPSRSLLWLGLVLGAVCASRGPAAPGNATDPLNVLLIIVDDLRPSLGCYGNKLIRSPNIDQLASRSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDSPYSWSVPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVVDVPEGTLPDKQSTEQAIQLLGKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENVSLAPDPQVPTGLPLVAYNPWMDLRQREDIQALNLSVPYGPIPADFQRKIRQSYFACVSYLDTQVGRLLSALDDLQLASSTIVAFTSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGRTAPLPVEGEKFFPYLDPFDSVSEVPEPGRQTGDLVELLSLFPTLAGLAGLRVPPRCPIPSFHMELCREGRNLLKLFEDHGEEEEPHVRSNPRELVAYSQYPRPADSPQWNSDKPSLEDIKVMGYSIRTVDYRYTVWVGFNPQEFLANFSDIHAGELYFVASDPLQDHNVYNDSQGGTLPQSFMP", "length": 547, "header": "tr|A0AAA9SE69-1|A0AAA9SE69_BOVIN Isoform 1 of Iduronate 2-sulfatase OS=Bos taurus OX=9913 GN=IDS PE=3 SV=1 CANONICAL=A0AAA9SE69-1" }, "locus": { "chromosome": "X", "start_pos": 32006498, "end_pos": 31991468, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089505.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089505.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081883.1" } ] } }, { "isoform_ac": "A0AAA9TKB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69/entry#A0AAA9TKB3-1", "sequence": { "sequence": "MPPPSRSLLWLGLVLGAVCASRGPAAPGNATDPLNVLLIIVDDLRPSLGCYGNKLIRSPNIDQLASRSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGTACPAESGLSFFVPGDWRPLLGLELSLQRPFWARWTPC", "length": 175, "header": "tr|A0AAA9TKB3-1|A0AAA9TKB3_BOVIN Computationally mapped isoform of Iduronate 2-sulfatase OS=Bos taurus OX=9913 GN=IDS PE=3 SV=1 CANONICAL=A0AAA9SE69-1" }, "locus": { "chromosome": "X", "start_pos": 32006498, "end_pos": 32005014, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098891.1" } ] } }, { "isoform_ac": "F1N2D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69/entry#F1N2D5-1", "sequence": { "sequence": "MPPPSRSLLWLGLVLGAVCASRGPAAPGNATDPLNVLLIIVDDLRPSLGCYGNKLIRSPNIDQLASRSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDSPYSWSVPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVVDVPEGTLPDKQSTEQAIQLLGKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENVSLAPDPQVPTGLPLVAYNPWMDLRQREDIQALNLSVPYGPIPADFQRKIRQSYFACVSYLDTQVGRLLSALDDLQLASSTIVAFTSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGRTAPLPVEGEKFFPYLDPFDSVSEVPEPGRQTGDLVELLSLFPTLAGLAGLRVPPRCPIPSFHMELCREGRNLLKLFEDHGEEEEPHVRSNPRELVAYSQYPRPADSPQWNSDKPSLEDIKVMGYSIRTVDYRMDA", "length": 498, "header": "tr|F1N2D5-1|A0AAA9SE69_BOVIN Computationally mapped isoform of Iduronate 2-sulfatase OS=Bos taurus OX=9913 GN=IDS PE=3 SV=4 CANONICAL=A0AAA9SE69-1" }, "locus": { "chromosome": "X", "start_pos": 32006498, "end_pos": 31987718, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014683.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014683.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014683.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014683.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:541272", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541272", "resource": "KEGG Pathway" }, { "id": "R-BTA-2024096", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024096", "resource": "Reactome", "description": "HS-GAG degradation" }, { "id": "R-BTA-2024101", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024101", "resource": "Reactome", "description": "CS/DS degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BS38-1", "protein_name": "Iduronate 2-sulfatase", "gene_name": "IDS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPPGRGLLWLGLVLGSACASLGSAAPGSVATDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRAHAGNFSTIPQYFKQNGYVTVSVGKVFHPGISSNHSDDSPYSWSLPPYHPSSEKYENTKTCKGPDGELHANLLCPVDVAEVPEGTLPDKQSTERAIQLLEKLRTSAVPFFLAVGYHKPHIPFRYPQEFQKLYPLENVTLAPDPQVPAGLPPVAYNPWMDIRQREDVQALNLSVPYGPIPTDFQRKIRQSYFASVSYVDTQVGRLLSALDGLELARSTIVALTSDHGWALGEHGEWAKYSNFDVATRVPLLVYVPGRTAPLPEAGGRLFPYIDPFASASESMEPGRQAGDLVELLSLFPTLAGLAGLRVPPRCPVPSFHVELCREGRNLLKYFQFGDLEEEPHARGNPRELVAYSQYPRPADAPQWNSDKPSLKDIKVMGYSIRTVDYRYTVWVGFSPREFLANFSDVHAGELYFVDSDPWQDHNVYNASQGRALPPPLMPTPEGT", "length": 553 }, "evidence": [ { "id": "A0AAA9SE69", "url": "https://omabrowser.org/oma/group/A0AAA9SE69/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1LLW8-1", "protein_name": "Iduronate 2-sulfatase", "gene_name": "Ids", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPPPPPPPTTWRQLSFSLLLGFFCIALVSAAQGNSATDALNILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSIVFENAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHTNLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGKTALLPAAGEKLFPYQDPFDPASELMGAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPIPSFHVELCREGHNLQRYLQLHDLEEDPYLFGNPRELIAYSQYPRPADFPQWNSDKPSLKDIKVMGYSIRTIDYRYTVWVGFSPTEFLANFSDIHAGELYFVDSDPLQDHNVYNDSQHGGLLLSLRP", "length": 554 }, "evidence": [ { "id": "A0AAA9SE69", "url": "https://omabrowser.org/oma/group/A0AAA9SE69/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P22304-1", "protein_name": "Iduronate 2-sulfatase", "gene_name": "IDS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP", "length": 550 }, "evidence": [ { "id": "A0AAA9SE69", "url": "https://omabrowser.org/oma/group/A0AAA9SE69/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q08890-1", "protein_name": "Iduronate 2-sulfatase", "gene_name": "Ids", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPPPPPPIWRQLSFSLLLGSFCIALESAAQGNSATDALNILLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSVLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHSGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHSDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHANLLCPVDVADVPEGTLPDKQSTEEAIRLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPEDFQRKIRQSYFASVSYLDTQVGHVLSALDDLRLAHNTIIAFTSDHGWALGEHGEWAKYSNFDVATRVPLMLYVPGRTAPLPAAGQKLFPYRDPFDPASDWMDAGRHTEDLVELVSLFPTLAGLAGLPVPPRCPIPSFHVELCREGQNLQKHLQLHDLEEEPDLFGNPRELIAYSQYPRPADFPQWNSDKPSLNDIKVMGYSIRTVDYRYTVWVGFDPSEFLANFSDIHAGELYFVDSDPLQDHNVYNDSQHGGLLHSLRP", "length": 552 }, "evidence": [ { "id": "A0AAA9SE69", "url": "https://omabrowser.org/oma/group/A0AAA9SE69/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VZP8-1", "protein_name": "Iduronate 2-sulfatase", "gene_name": "Ids", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MITARLLLSLMMPVLLDAAAPPRRPNVVMVIFDDLRPVIGAYGDTLASTPYLDNFARGSHIFTRVYSQQSLCAPSRNSLLTGRRPDTLHLYDFYSYWRTFTGNFTTLPQYFKEHGYYTYSCGKVFHPGLSSNNTDDYPLSWSAPAFRPRTEQFMNSPVCPDKEGILRKNLICPVELQTQPYKTLPDIESVAEALRFVGSRSRHSQEPFFLAMGFHKPHINFRFPRQFLSRFNLSQFYNYTEDSLKPPDMPAVAWNPYTDVRARDDFKHSNISFPYGPISPLQAAQIRQSYYASVSYVDDLFGKLIGGLDLDETVVVALGDHGWSLGEHAEWAKYSNFEVALRVPLIIRSPQFPVAQTKYYHGITELLDVFPTLVDLAGLPKLDKCQSSQELTCGEGKSLYHQLMGLGRADEHVALSQYPRPGMLPTKHPNSDKPKLRNIKIMGYSLRTDIYRYTMWVRFHAQNFSRDWHDVYGEELYDHRLDSGEELNLMPLPQFDDVRQRLRRRLMEMVGS", "length": 512 }, "evidence": [ { "id": "A0AAA9SE69", "url": "https://omabrowser.org/oma/group/A0AAA9SE69/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "iduronate-2-sulfatase activity", "id": "GO:0004423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004423", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "dermatan sulfate proteoglycan catabolic process", "id": "GO:0030209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "glycosaminoglycan catabolic process", "id": "GO:0006027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "heparan sulfate proteoglycan catabolic process", "id": "GO:0030200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "carbohydrate derivative catabolic process", "id": "GO:1901136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal lumen", "id": "GO:0043202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1678650", "name": "IDS hydrolyses Heparan sulfate chain(5)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2090080" ], "output_participant_list": [ "R-ALL-1606845" ], "enzyme_list": [ "A0AAA9SE69-1" ], "evidence": [ { "id": "R-BTA-1678650", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1678650" } ] }, { "id": "R-BTA-1793182", "name": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2065213" ], "output_participant_list": [ "R-ALL-2065269" ], "enzyme_list": [ "A0AAA9SE69-1" ], "evidence": [ { "id": "R-BTA-1793182", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1793182" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1606845", "participant_name": "SO4(2-) [lysosomal lumen]", "crossref": [ { "id": "16189", "database": "ChEBI", "url": "" }, { "id": "C00059", "database": "COMPOUND", "url": "" }, { "id": "8144977", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-2065213", "participant_name": "ChEBI:63517 chain [lysosomal lumen]", "crossref": [ { "id": "747397", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2065269", "participant_name": "ChEBI:63516 chain [lysosomal lumen]", "crossref": [ { "id": "747395", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2090080", "participant_name": "IdoA2S-GlcNS3S- group [lysosomal lumen]", "crossref": [ { "id": "63808", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SE69", "gene_name": "IDS", "activity": [ { "ec_number": "3.1.6.13", "activity": "Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.", "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ] }, { "ec_number": "3.1.6.13", "activity": "", "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SE69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE69" }, { "id": "PF00884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfatase N-terminal", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 412, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.6.13", "ec_name": "Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.", "evidence": [ { "id": "3.1.6.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.6.13" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 141, "end_pos": 143 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 534, "end_pos": 536 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SB98-1", "uniprot_ac": "A0AAA9SB98", "uniprot_id": "A0AAA9SB98_BOVIN", "mass": { "chemical_mass": 56622.0, "monoisotopic_mass": 56622.0 }, "refseq": {}, "gene_names": [ { "name": "TTC8", "type": "recommended", "evidence": [ { "id": "A0AAA9SB98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 8", "type": "synonym", "evidence": [ { "id": "A0AAA9SB98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98", "locus": { "chromosome": "10", "start_pos": 100562417, "end_pos": 100502795, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030432", "url": "https://www.ensembl.org/id/ENSBTAG00000030432" } ] } } ], "crossref": [ { "id": "A0AAA9SB98", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SB98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030432", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030432", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21341", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21341", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "6VBU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VBU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VBV", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VBV&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VNW", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VNW&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VOA", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VOA&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "F1N4X0", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1N4X0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QMGVNSA", "url": "https://omabrowser.org/oma/group/QMGVNSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N4X0", "url": "https://www.orthodb.org/?gene=F1N4X0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44177:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44177:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006vbu", "url": "https://www.rcsb.org/structure/pdb_00006vbu", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006vbv", "url": "https://www.rcsb.org/structure/pdb_00006vbv", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006vnw", "url": "https://www.rcsb.org/structure/pdb_00006vnw", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006voa", "url": "https://www.rcsb.org/structure/pdb_00006voa", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VBU", "url": "https://www.rcsb.org/structure/6VBU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VBV", "url": "https://www.rcsb.org/structure/6VBV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VNW", "url": "https://www.rcsb.org/structure/6VNW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VOA", "url": "https://www.rcsb.org/structure/6VOA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4X0", "url": "https://www.uniprot.org/uniprotkb/F1N4X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4X0-1", "url": "https://www.uniprot.org/uniprotkb/F1N4X0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPLLLAWSYFRRRRFQLCADLCTQMLEKSPCDQAAWILKARALTEMVYVDEIDVDEEGIAEMILDENAIAQVPRPGTSLKLPGTNQTGGPSPAVRPVTQAGRPITGFLRPSTQSGRPGTIEQAIKTPRTAYTARPIASSSGRFVRLGTASMLTSPDGPFINLSRLNLAKYAQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGLYREAEKQFKSALKQQEMVDTFLYLAKVYISLDQPLTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNISSATEYYKEVLKQDNTHVEAIACIGSNHFYTDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEVADVWYNLGHVAVGTGDTNLAHQCFRLALVSNNQHAEAYNNLAVLEMRRGHVEQAKALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYAAAKKSEAAFPDHVDTQHLIKQLEQHFAML", "length": 501, "header": "tr|A0AAA9SB98-1|A0AAA9SB98_BOVIN Isoform 1 of Tetratricopeptide repeat domain 8 OS=Bos taurus OX=9913 GN=TTC8 PE=4 SV=1 CANONICAL=A0AAA9SB98-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98/entry#A0AAA9SB98-1", "sequence": { "sequence": "MEPLLLAWSYFRRRRFQLCADLCTQMLEKSPCDQAAWILKARALTEMVYVDEIDVDEEGIAEMILDENAIAQVPRPGTSLKLPGTNQTGGPSPAVRPVTQAGRPITGFLRPSTQSGRPGTIEQAIKTPRTAYTARPIASSSGRFVRLGTASMLTSPDGPFINLSRLNLAKYAQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGLYREAEKQFKSALKQQEMVDTFLYLAKVYISLDQPLTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNISSATEYYKEVLKQDNTHVEAIACIGSNHFYTDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEVADVWYNLGHVAVGTGDTNLAHQCFRLALVSNNQHAEAYNNLAVLEMRRGHVEQAKALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYAAAKKSEAAFPDHVDTQHLIKQLEQHFAML", "length": 501, "header": "tr|A0AAA9SB98-1|A0AAA9SB98_BOVIN Isoform 1 of Tetratricopeptide repeat domain 8 OS=Bos taurus OX=9913 GN=TTC8 PE=4 SV=1 CANONICAL=A0AAA9SB98-1" }, "locus": { "chromosome": "10", "start_pos": 100561729, "end_pos": 100503067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126922.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126922.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080743.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080743.1" } ] } }, { "isoform_ac": "F1N4X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98/entry#F1N4X0-1", "sequence": { "sequence": "MEPLLLAWSYFRRRRFQLCADLCTQMLEKSPCDQEPDPALPVSQAAWILKARALTEMVYVDEIDVDEEGIAEMILDENAIAQVPRPGTSLKLPGTNQTGGPSPAVRPVTQAGRPITGFLRPSTQSGRPGTIEQAIKTPRTAYTARPIASSSGRFVRLGTASMLTSPDGPFINLSRLNLAKYAQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGLYREAEKQFKSALKQQEMVDTFLYLAKVYISLDQPLTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNISSATEYYKEVLKQDNTHVEAIACIGSNHFYTDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEVADVWYNLGHVAVGTGDTNLAHQCFRLALVSNNQHAEAYNNLAVLEMRRGHVEQAKALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYAAAKKSEAAFPDHVDTQHLIKQLEQHFAML", "length": 511, "header": "tr|F1N4X0-1|F1N4X0_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 8 OS=Bos taurus OX=9913 GN=TTC8 PE=1 SV=3 CANONICAL=A0AAA9SB98-1" }, "locus": { "chromosome": "10", "start_pos": 100561729, "end_pos": 100503067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042964.6", "url": "https://www.ensembl.org/id/ENSBTAT00000042964.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040568.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040568.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure and activation mechanism of the BBSome membrane protein trafficking complex.", "journal": "Elife", "date": "2020", "authors": "Singh SK, Gui M, Koh F, Yip MC, Brown A", "evidence": [ { "database": "UniProtKB", "id": "F1N4X0", "url": "https://www.uniprot.org/uniprotkb/F1N4X0" } ], "reference": [ { "type": "PubMed", "id": "31939736", "url": "https://glygen.org/publication/PubMed/31939736" } ] }, { "title": "Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.", "journal": "Elife", "date": "2020", "authors": "Yang Shuang, Bahl Kriti, Chou Hui-Ting, Woodsmith Jonathan, Stelzl Ulrich, Walz Thomas, Nachury Maxence V", "evidence": [ { "database": "UniProtKB", "id": "F1N4X0", "url": "https://www.uniprot.org/uniprotkb/F1N4X0" } ], "reference": [ { "type": "PubMed", "id": "32510327", "url": "https://glygen.org/publication/PubMed/32510327" } ] } ], "pathway": [ { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HBG0-1", "protein_name": "Tetratricopeptide repeat protein 8", "gene_name": "Ttc8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGSEMEPLLRAWSYFRRRKFQLCADLCTQMLEKSPYDQAAWILKARALTEMVYIDEIDVDQEGIAEMILDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQTGRPGTMEQAIRTPRTAYTARPVTSSSGRFVRLGTASMLTSPEGPFINLSRLNLTKYSQKPKLAKALFEYIFHHENDVKMALDLASLSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYIILDQPMTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNSSSASEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHIAVGIGDTNLAHQCFRLALVHNNHHAEAYNNLAVLEMRKGHIEQARALLQTASSLAPHMYEPHFNFATVSDKIGDLQRSYVAAQKSEAAFPEHVDTKHLIKQLKQHFAML", "length": 505 }, "evidence": [ { "id": "A0AAA9SB98", "url": "https://omabrowser.org/oma/group/A0AAA9SB98/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8TAM2-1", "protein_name": "Tetratricopeptide repeat protein 8", "gene_name": "TTC8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSEMEPLLLAWSYFRRRKFQLCADLCTQMLEKSPYDQEPDPELPVHQAAWILKARALTEMVYIDEIDVDQEGIAEMMLDENAIAQVPRPGTSLKLPGTNQTGGPSQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYIFHHENDVKTIHLEDVVLHLGIYPFLLRNKNHIEKNALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDHVDTQHLIKQLRQHFAML", "length": 541 }, "evidence": [ { "id": "A0AAA9SB98", "url": "https://omabrowser.org/oma/group/A0AAA9SB98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VD72-1", "protein_name": "Tetratricopeptide repeat protein 8", "gene_name": "Ttc8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSEMEPLLRAWSYFRRRKFQLCADLCTQMLEKSPYDQEPAPDLPVSQAAWILKARALTEMVYIDEIDVDQEGIAEMILDENAIAQVPRPGTSLKLPGTNQTGGPTQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVRLGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYILHHENDVKMALDLASLSTEYSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYIILDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNSSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHIAVGIGDTNLAHQCFRLALVHNNHHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATVSDKIGDLQRSYVAAQKSEVAFPEHVDTQHLIKQLKQHFAML", "length": 515 }, "evidence": [ { "id": "A0AAA9SB98", "url": "https://omabrowser.org/oma/group/A0AAA9SB98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VPP9-1", "protein_name": "Bardet-Biedl syndrome 8", "gene_name": "BBS8", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASAMLATLELDYFRAVSLYRRRSYERCAELCNALLQAGHDGHVQLFTTKEEEEEEQHQQQQAEHSRFGSNLQRIGPRPRGAAGGGAGAVDSGPSIMMPTWLMEGVWQLKMRALTQRVYVDDLDEDDGGNEATEEVEFERIATAARPGSSIKTAFQPRPLTSQRAQQARSRGAGVAHSSDGRLNSSRPGSAAVARPGTSLSRPGSSLGSRCGTASRIRATSAAAFNVGDATSKLYQASRLNPTIYAERETLVKALFQFLYYHEADVQKAHSLCQAVLEVERQKPSGSTGCTLSWWWQQQMGRCLLALHYPRRAEPFLQQSLTSFPHPDTYLLLSRVYQRIKQPERALLVIGEVVDSRPFDVTYRLEQARIHQAMEQQEDALQLYRLAAKLHPINVESLASIAVGYFYDNNPEMALMYYRRILSLGAQSPELYCNIALCCLYGGQIDLVLPCFQRALATATQPGQKSDIWYNLSFVAVTSGDFNLAKRCLQLCLTSDAQNGAALNNLAVLAAQSGDILGAKSYLNAAKDVMPDAAEVTTNLQFMDVHYKL", "length": 549 }, "evidence": [ { "id": "A0AAA9SB98", "url": "https://omabrowser.org/oma/group/A0AAA9SB98/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "establishment of anatomical structure orientation", "id": "GO:0048560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048560", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "BBSome", "id": "GO:0034464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SB98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SDE0-1", "uniprot_ac": "A0AAA9SDE0", "uniprot_id": "A0AAA9SDE0_BOVIN", "mass": { "chemical_mass": 82606.0, "monoisotopic_mass": 82606.0 }, "refseq": {}, "gene_names": [ { "name": "CDH8", "type": "recommended", "evidence": [ { "id": "A0AAA9SDE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ] } ], "protein_names": [ { "name": "Cadherin 8", "type": "synonym", "evidence": [ { "id": "A0AAA9SDE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cadherins are calcium-dependent cell adhesion proteins.", "evidence": [ { "database": "UniProtKB", "id": "G3MZM2", "url": "https://www.uniprot.org/uniprotkb/G3MZM2#function" }, { "database": "UniProtKB", "id": "RU004357", "url": "https://www.uniprot.org/uniprotkb/RU004357#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0", "locus": { "chromosome": "18", "start_pos": 29353238, "end_pos": 29761789, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022783", "url": "https://www.ensembl.org/id/ENSBTAG00000022783" } ] } } ], "crossref": [ { "id": "A0AAA9SDE0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022783", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022783", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521039", "url": "https://www.ncbi.nlm.nih.gov/gene/521039", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IYMAPMA", "url": "https://omabrowser.org/oma/group/IYMAPMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJ74", "url": "https://www.orthodb.org/?gene=E1BJ74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZM2", "url": "https://www.orthodb.org/?gene=G3MZM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027:SF273", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027:SF273", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ74", "url": "https://www.uniprot.org/uniprotkb/E1BJ74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ74-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZM2", "url": "https://www.uniprot.org/uniprotkb/G3MZM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZM2-1", "url": "https://www.uniprot.org/uniprotkb/G3MZM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPERLAEMLLDLWTPLIILWITLPPCIYSAPMNQSPVLMSGSPLELNRLSEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSSDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRWGLPAQWWEERNLIRMGLFSGTRITLSLQFTFSHKDTKRNCVTQWTT", "length": 744, "header": "tr|A0AAA9SDE0-1|A0AAA9SDE0_BOVIN Isoform 1 of Cadherin 8 OS=Bos taurus OX=9913 GN=CDH8 PE=4 SV=1 CANONICAL=A0AAA9SDE0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0/entry#A0AAA9SDE0-1", "sequence": { "sequence": "MPERLAEMLLDLWTPLIILWITLPPCIYSAPMNQSPVLMSGSPLELNRLSEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSSDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRWGLPAQWWEERNLIRMGLFSGTRITLSLQFTFSHKDTKRNCVTQWTT", "length": 744, "header": "tr|A0AAA9SDE0-1|A0AAA9SDE0_BOVIN Isoform 1 of Cadherin 8 OS=Bos taurus OX=9913 GN=CDH8 PE=4 SV=1 CANONICAL=A0AAA9SDE0-1" }, "locus": { "chromosome": "18", "start_pos": 29746499, "end_pos": 29353451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081854.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081854.1" } ] } }, { "isoform_ac": "E1BJ74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0/entry#E1BJ74-1", "sequence": { "sequence": "MPERLAEMLLDLWTPLIILWITLPPCIYSAPMNQSPVLMSGSPLELNRLSEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRLPSSSVCGIFQARRLEWVAISSSKGSSRPRDQTHVSCMGRWILYCSTTREAPTSTEWVLINGQC", "length": 490, "header": "tr|E1BJ74-1|A0AAA9SDE0_BOVIN Computationally mapped isoform of Cadherin 8 OS=Bos taurus OX=9913 GN=CDH8 PE=4 SV=4 CANONICAL=A0AAA9SDE0-1" }, "locus": { "chromosome": "18", "start_pos": 29746499, "end_pos": 29510723, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030925.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030925.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030891.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030891.5" } ] } }, { "isoform_ac": "G3MZM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0/entry#G3MZM2-1", "sequence": { "sequence": "MPERLAEMLLDLWTPLIILWITLPPCIYSAPMNQSPVLMSGSPLELNRLSEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSSDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET", "length": 799, "header": "tr|G3MZM2-1|G3MZM2_BOVIN Computationally mapped isoform of Cadherin 8 OS=Bos taurus OX=9913 GN=CDH8 PE=4 SV=2 CANONICAL=A0AAA9SDE0-1" }, "locus": { "chromosome": "18", "start_pos": 29746499, "end_pos": 29354242, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065042.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065042.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055022.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055022.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-418990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "resource": "Reactome", "description": "Adherens junctions interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UQW4-1", "protein_name": "Cadherin 8", "gene_name": "CDH8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPERLSAMLLDLWTPLIILWITLPPCIYMAPMNQSPVLMSGSPLELNRLSEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSSRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSSDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRRGMPAQWWEERNPIQTGLFSGSRMTHSLHFIFSHKDTKINCITQRTT", "length": 744 }, "evidence": [ { "id": "A0AAA9SDE0", "url": "https://omabrowser.org/oma/group/A0AAA9SDE0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XVN0-1", "protein_name": "Cadherin 8", "gene_name": "CDH8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTGKLNGSCFYNLSYFYVDCAVNTWRSSCGTMPERLTEMLMDTWTPLIILWITVLPSIYMAPMNQSQVLPSGSSTGLKRLTEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSSKIKYILSGDGAGTIFVINDKTGDIHAMKRLDREEKAEYTLTAQAVDRDTNKPLEPPSEFIIKVQDINDNAPEFVDGPYHATVPEMSVVGTFVTKVTATDADDPVYGNSAKLVYSILEGQPYFSIEPHTAIIKTALPNMDREAKEEYFVVIQAKDMGGHMGGLSGTTTVTITLTDVNDNPPKFAQSLYHFSVMEDVALGEPIGRVKANDLDIGENAKSSYDIIEGDGMDIFEITTDAQTQDGVIRVRKPLDFETKKSYTLKVEAANIHIDPRFISGGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAAINSVIGQVTAHDPDVSSSPIRFSIDRHTDLERQFNINAEDGKITLATPLDRETNMWHNITIVATETRNHSQVSRVPVTIKVLDVNDNAPEFASEHEAFLCENGKPGQVIQIVSAVDKDDPKNGHYFLYSLLPEMINNPNFTIKKNEDNTLSILAKHNGFSRQKQEVYLLPIIISDSGNPPMSSTSTLTIRVCGCSSDGIVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSAAGSLSSLESSASDSDQNFDYLSEWGPRFKRLGELYSVGESDKET", "length": 830 }, "evidence": [ { "id": "A0AAA9SDE0", "url": "https://omabrowser.org/oma/group/A0AAA9SDE0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P55286-1", "protein_name": "Cadherin-8", "gene_name": "CDH8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET", "length": 799 }, "evidence": [ { "id": "A0AAA9SDE0", "url": "https://omabrowser.org/oma/group/A0AAA9SDE0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97291-1", "protein_name": "Cadherin-8", "gene_name": "Cdh8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPERLAETLMDLWTPLIILWITLPSCVYTAPMNQAHVLTTGSPLELSRQSEDMRILSRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSSRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET", "length": 799 }, "evidence": [ { "id": "A0AAA9SDE0", "url": "https://omabrowser.org/oma/group/A0AAA9SDE0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "catenin complex", "id": "GO:0016342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016342", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "cell-cell junction assembly", "id": "GO:0007043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007043", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "adherens junction organization", "id": "GO:0034332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034332", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "regulation of synapse organization", "id": "GO:0050807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050807", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" }, { "name": "cell-cell adhesion mediated by cadherin", "id": "GO:0044331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044331", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE0" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 167, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 473, "end_pos": 475 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAG4-1", "uniprot_ac": "A0AAA9SAG4", "uniprot_id": "A0AAA9SAG4_BOVIN", "mass": { "chemical_mass": 27357.0, "monoisotopic_mass": 27357.0 }, "refseq": {}, "gene_names": [ { "name": "MBP", "type": "recommended", "evidence": [ { "id": "A0AAA9SAG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ] } ], "protein_names": [ { "name": "Myelin basic protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SAG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MBP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4", "locus": { "chromosome": "24", "start_pos": 2328578, "end_pos": 2223861, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022890", "url": "https://www.ensembl.org/id/ENSBTAG00000022890" } ] } } ], "crossref": [ { "id": "A0AAA9SAG4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022890", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022890", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618684", "url": "https://www.ncbi.nlm.nih.gov/gene/618684", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618684", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618684", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFFKNIX", "url": "https://omabrowser.org/oma/group/HFFKNIX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAL4", "url": "https://www.orthodb.org/?gene=A0A3Q1MAL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRJ3", "url": "https://www.orthodb.org/?gene=A0A3Q1MRJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QBP1", "url": "https://www.orthodb.org/?gene=F6QBP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11429", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11429", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11429:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11429:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MAL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAL4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6E6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6E6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6E6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QBP1", "url": "https://www.uniprot.org/uniprotkb/F6QBP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QBP1-1", "url": "https://www.uniprot.org/uniprotkb/F6QBP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNHAGKRDFGAEKGNKDSETNRGEHEKKRNTRDLSREISEDSDVFGAADVVPNNGAPSQDTAVTDSKRTADPKNAWPEASPADPGGRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAAAPGAVDAMAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR", "length": 252, "header": "tr|A0AAA9SAG4-1|A0AAA9SAG4_BOVIN Isoform 1 of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=1 CANONICAL=A0AAA9SAG4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#A0A3Q1MAL4-1", "sequence": { "sequence": "MLSQVPPRARAGWFGGSAASGGSRAAVQPGPESAPHRAAPRGARVRPEPARRSRGEVVGARAAGGRPGSRRQCLPGSQEAREAGEERRARPALGAAARLRRRASKDESAAPETAAPTPKAAPEPRDPARLGPGRWEAARTPRCPQPGETIAARWVTSPRAASEDSRLRMGNHAGKRDFGAEKGNKDSETNRGEHEKKRNTRDLSREISEDSDVFGAADVVPNNGAPSQDTAVTDSKRTADPKNAWPEASPADPGGRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAAAPGAVDAMAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIVTPRTPPPSQGKGAEGQKPGFGYGGRASDYKSAHKGLKGHDAQGTLSKIFKLGGRDSRSGSPMARR", "length": 460, "header": "tr|A0A3Q1MAL4-1|A0A3Q1MAL4_BOVIN Computationally mapped isoform of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=2 CANONICAL=A0AAA9SAG4-1" }, "locus": { "chromosome": "24", "start_pos": 2327255, "end_pos": 2224060, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066944.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066944.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067262.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067262.2" } ] } }, { "isoform_ac": "A0A3Q1MRJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#A0A3Q1MRJ3-1", "sequence": { "sequence": "MAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIAQTASLTLSCRGLRARSQDSAMEAERLTTNRLTRDSRGTTPRARFPKSSSWEDETAVPGPRWQDAEAQLPSQNPVPSFLIQPPRR", "length": 178, "header": "tr|A0A3Q1MRJ3-1|A0A3Q1MRJ3_BOVIN Computationally mapped isoform of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=3 CANONICAL=A0AAA9SAG4-1" }, "locus": { "chromosome": "24", "start_pos": 2327316, "end_pos": 2296211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075974.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075974.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074415.3", "url": "https://www.ensembl.org/id/ENSBTAP00000074415.3" } ] } }, { "isoform_ac": "A0AAA9SAG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#A0AAA9SAG4-1", "sequence": { "sequence": "MGNHAGKRDFGAEKGNKDSETNRGEHEKKRNTRDLSREISEDSDVFGAADVVPNNGAPSQDTAVTDSKRTADPKNAWPEASPADPGGRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAAAPGAVDAMAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR", "length": 252, "header": "tr|A0AAA9SAG4-1|A0AAA9SAG4_BOVIN Isoform 1 of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=1 CANONICAL=A0AAA9SAG4-1" }, "locus": { "chromosome": "24", "start_pos": 2327255, "end_pos": 2248223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080897.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080897.1" } ] } }, { "isoform_ac": "A0AAA9SGG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#A0AAA9SGG0-1", "sequence": { "sequence": "MGNHAGKRDFGAEKGNKDSETNRGEHEKKRNTRDLSREISEDSDVFGAADVVPNNGAPSQDTAVTDSKRTADPKNAWPEASPADPGGRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAAAPGAVDAMAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIVTPRTPPPSQGKVRALKGAEGQKPGFGYGGRASDYKSAHKGLKGHDAQGTLSKIFKLGPDARTGLEKVEKGSRLRAGGARELR", "length": 309, "header": "tr|A0AAA9SGG0-1|A0AAA9SGG0_BOVIN Computationally mapped isoform of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=1 CANONICAL=A0AAA9SAG4-1" }, "locus": { "chromosome": "24", "start_pos": 2323640, "end_pos": 2248223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131855.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131855.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085253.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085253.1" } ] } }, { "isoform_ac": "A0ABI0P6E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#A0ABI0P6E6-1", "sequence": { "sequence": "MAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKVPWLKQSKSPLGPHARSPPGLCNMYQDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIVTPRTPPPSQGKGAEGQKPGFGYGGRASDYKSAHKGLKGRTRPGLGGSRDGAGARGPQLPPRRPTFYGARPEGGGGAAQSGGRTFREPRGGRGYRESEGDRWRARHAGAHSEH", "length": 232, "header": "tr|A0ABI0P6E6-1|A0ABI0P6E6_BOVIN Computationally mapped isoform of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=1 CANONICAL=A0AAA9SAG4-1" }, "locus": { "chromosome": "24", "start_pos": 2327994, "end_pos": 2296211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145133.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145133.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107698.1" } ] } }, { "isoform_ac": "F6QBP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4/entry#F6QBP1-1", "sequence": { "sequence": "MGNHAGKRDFGAEKGNKDSETNRGEHEKKRNTRDLSREISEDSDVFGAADVVPNNGAPSQDTAVTDSKRTADPKNAWPEASPADPGGRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAAAPGAVDAMAAQKRPSQRSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGSDRGAPKRGSGKDGHHAARTTHYGSLPQKAQHGRPQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRASDYKSAHKGLKGHDAQGTLSKIFKLGGRDSRSGSPMARR", "length": 303, "header": "tr|F6QBP1-1|F6QBP1_BOVIN Computationally mapped isoform of Myelin basic protein OS=Bos taurus OX=9913 GN=MBP PE=3 SV=2 CANONICAL=A0AAA9SAG4-1" }, "locus": { "chromosome": "24", "start_pos": 2327255, "end_pos": 2248223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002984.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002984.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002984.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002984.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618684", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618684", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P02688-1", "protein_name": "Myelin basic protein", "gene_name": "Mbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKVPWLKQSRSPLPSHARSRPGLCHMYKDSHTRTTHYGSLPQKSQRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKLGGRDSRSGSPMARR", "length": 195 }, "evidence": [ { "id": "A0AAA9SAG4", "url": "https://omabrowser.org/oma/group/A0AAA9SAG4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of myelin sheath", "id": "GO:0019911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "myelin sheath", "id": "GO:0043209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" }, { "name": "internode region of axon", "id": "GO:0033269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033269", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" }, { "name": "compact myelin", "id": "GO:0043218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043218", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SCT2-1", "uniprot_ac": "A0AAA9SCT2", "uniprot_id": "A0AAA9SCT2_BOVIN", "mass": { "chemical_mass": 67293.0, "monoisotopic_mass": 67293.0 }, "refseq": { "ac": "XP_005210583", "name": "regulator of G-protein signaling 3 isoform X7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210583" }, "gene_names": [ { "name": "RGS3", "type": "recommended", "evidence": [ { "id": "A0AAA9SCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2" } ] }, { "name": "RGS3", "type": "synonym", "evidence": [ { "id": "XP_005210583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210583" } ] } ], "protein_names": [ { "name": "Regulator of G protein signaling 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2/entry#names_and_taxonomy" } ] }, { "name": "regulator of G-protein signaling 3 isoform X7", "type": "synonym", "evidence": [ { "id": "XP_005210583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210583" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2", "locus": { "chromosome": "8", "start_pos": 102832521, "end_pos": 102829115, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004499", "url": "https://www.ensembl.org/id/ENSBTAG00000004499" } ] } } ], "crossref": [ { "id": "A0AAA9SCT2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SCT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06711", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06711", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08685", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08685", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527349", "url": "https://www.ncbi.nlm.nih.gov/gene/527349", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46848:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46848:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005210583", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210583", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERSLHRVSLGSRRAQPGLSFYLTTFGQLKLSIDAQDRVLRLHIIEGRGLMSKEPGVCDSYVKISLIPEDNRLCRQKTQTVPDCRDPIFHEYFFFPVQEEDEQKRLLLTVWNRAGDSRQSGLIGCMSFGVKSLLTPDKEVNGWYYLLGEALGQTKHLKVARRRLRPLREPLLSTPGGEDAENGEKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLRLNERPVEHWKCVELAHEIRSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTLDLLSPPNKREKNCTHGAQARPEQRHSCHLVCDSSDGLLLGGWERYTELTKRGSQHTLPALSRATAPTDPNYIILAPLNPGSQLLRPVYQEDAIPEESGSPSKGKSYTGLGKKCRLMKTVQTMKGRGNYQNCPVMRPHTPHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTKEDEPGRCNVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLATPSPDSKKLHPYGSLQQEMGPANSTNATQDRSFTSSGQTLIG", "length": 602, "header": "tr|A0AAA9SCT2-1|A0AAA9SCT2_BOVIN Isoform 1 of Regulator of G protein signaling 3 OS=Bos taurus OX=9913 GN=RGS3 PE=4 SV=1 CANONICAL=A0AAA9SCT2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2/entry#A0AAA9SCT2-1", "sequence": { "sequence": "MERSLHRVSLGSRRAQPGLSFYLTTFGQLKLSIDAQDRVLRLHIIEGRGLMSKEPGVCDSYVKISLIPEDNRLCRQKTQTVPDCRDPIFHEYFFFPVQEEDEQKRLLLTVWNRAGDSRQSGLIGCMSFGVKSLLTPDKEVNGWYYLLGEALGQTKHLKVARRRLRPLREPLLSTPGGEDAENGEKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLRLNERPVEHWKCVELAHEIRSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTLDLLSPPNKREKNCTHGAQARPEQRHSCHLVCDSSDGLLLGGWERYTELTKRGSQHTLPALSRATAPTDPNYIILAPLNPGSQLLRPVYQEDAIPEESGSPSKGKSYTGLGKKCRLMKTVQTMKGRGNYQNCPVMRPHTPHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTKEDEPGRCNVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLATPSPDSKKLHPYGSLQQEMGPANSTNATQDRSFTSSGQTLIG", "length": 602, "header": "tr|A0AAA9SCT2-1|A0AAA9SCT2_BOVIN Isoform 1 of Regulator of G protein signaling 3 OS=Bos taurus OX=9913 GN=RGS3 PE=4 SV=1 CANONICAL=A0AAA9SCT2-1" }, "locus": { "chromosome": "8", "start_pos": 102774707, "end_pos": 102695123, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092407.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092407.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080103.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080103.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 174, "start_aa": "Thr", "end_pos": 174, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr174", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 144, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SCT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCT2" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 187, "end_pos": 264, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 174 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 297, "end_pos": 299 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 586, "end_pos": 588 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SD70-1", "uniprot_ac": "A0AAA9SD70", "uniprot_id": "A0AAA9SD70_BOVIN", "mass": { "chemical_mass": 58668.0, "monoisotopic_mass": 58668.0 }, "refseq": { "ac": "XP_024839694", "name": "butyrophilin subfamily 2 member A2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839694" }, "gene_names": [ { "name": "LOC107131749", "type": "recommended", "evidence": [ { "id": "A0AAA9SD70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ] }, { "name": "LOC107131749", "type": "synonym", "evidence": [ { "id": "XP_024839694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839694" } ] } ], "protein_names": [ { "name": "Butyrophilin subfamily 2 member A2", "type": "synonym", "evidence": [ { "id": "A0AAA9SD70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70/entry#names_and_taxonomy" } ] }, { "name": "butyrophilin subfamily 2 member A2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024839694", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839694" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC107131749", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70", "locus": {} } ], "crossref": [ { "id": "A0AAA9SD70", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SD70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010852", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010852", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05713", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05713", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15819", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15819", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "107131749", "url": "https://www.ncbi.nlm.nih.gov/gene/107131749", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MZI6", "url": "https://www.orthodb.org/?gene=F1MZI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24100:SF139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24100:SF139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8851680", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8851680", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024839694", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839694", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZI6", "url": "https://www.uniprot.org/uniprotkb/F1MZI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZI6-1", "url": "https://www.uniprot.org/uniprotkb/F1MZI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLMEPVASLYFSLPGFLLFFQLLSSFAPMSVQFTVLGPAYPILAVVGEDATLRCHLSPEKNAEDMEVRWFRTQFSPAVFVYKGRRERTDEQMEQYRGRTTFVSEAISEGSVGLIIHNVTAHENGIYCCYFQEGRSYDEAIMHLTVTGLGSKPVIEMKSPEDGGIRLECTSAGWYPKPHAVWRGPHGETMPPLEEAYTVSADGLFLVTMAVIIRDHSVRNMSCSVINTLLDQEKETVIFIPESFIPRTSPWMVALVVILPSLLLLIAGSIYLIKKLHLGKKILSMQKEAENEEKEIAQQLQEELRWRRNLLHAADVVLDPDTAHPELFLSEDRRSVRRGPSRQSVPDNPERFDCRPCVLGLESYSLGRHYWEVEVKNVMVWAVGVCRDNVERKGEALLVPQNGFWTLDMFENQYRALSSPEKILPLKEHLHRVGVFLDYEAGDVSFYNMKDRSHIYTCPRSPFSGPLRPFFRLGSDDSPLCICPSFRGAQGVTVPEGGLVLHRAETHHNHQFLGLRAR", "length": 517, "header": "tr|A0AAA9SD70-1|A0AAA9SD70_BOVIN Isoform 1 of Butyrophilin subfamily 2 member A2 OS=Bos taurus OX=9913 GN=LOC107131749 PE=3 SV=2 CANONICAL=A0AAA9SD70-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70/entry#A0AAA9SD70-1", "sequence": { "sequence": "MLMEPVASLYFSLPGFLLFFQLLSSFAPMSVQFTVLGPAYPILAVVGEDATLRCHLSPEKNAEDMEVRWFRTQFSPAVFVYKGRRERTDEQMEQYRGRTTFVSEAISEGSVGLIIHNVTAHENGIYCCYFQEGRSYDEAIMHLTVTGLGSKPVIEMKSPEDGGIRLECTSAGWYPKPHAVWRGPHGETMPPLEEAYTVSADGLFLVTMAVIIRDHSVRNMSCSVINTLLDQEKETVIFIPESFIPRTSPWMVALVVILPSLLLLIAGSIYLIKKLHLGKKILSMQKEAENEEKEIAQQLQEELRWRRNLLHAADVVLDPDTAHPELFLSEDRRSVRRGPSRQSVPDNPERFDCRPCVLGLESYSLGRHYWEVEVKNVMVWAVGVCRDNVERKGEALLVPQNGFWTLDMFENQYRALSSPEKILPLKEHLHRVGVFLDYEAGDVSFYNMKDRSHIYTCPRSPFSGPLRPFFRLGSDDSPLCICPSFRGAQGVTVPEGGLVLHRAETHHNHQFLGLRAR", "length": 517, "header": "tr|A0AAA9SD70-1|A0AAA9SD70_BOVIN Isoform 1 of Butyrophilin subfamily 2 member A2 OS=Bos taurus OX=9913 GN=LOC107131749 PE=3 SV=2 CANONICAL=A0AAA9SD70-1" }, "locus": { "chromosome": "23", "start_pos": 31615030, "end_pos": 31605837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092726.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092726.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081486.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081486.2" } ] } }, { "isoform_ac": "F1MZI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70/entry#F1MZI6-1", "sequence": { "sequence": "MLMEPVASLYFSLPGFLLFFQLLSSFAPMSVQFTVLGPAYPILAVVGEDATLRCHLSPEKNAEDMEVRWFRTQFSPAVFVYKGRRERTDEQMEQYRGRTTFVSEAISEGSVGLIIHNVTAHENGIYCCYFQEGRSYDEAIMHLTVTGLGSKPVIEMKSPEDGGIRLECTSAGWYPKPHAVWRGPHGETMPPLEEAYTVSADGLFLVTMAVIIRDHSVRNMSCSVINTLLDQEKETVIFIPESFIPRTSPWMVALVVILPSLLLLIAGSIYLIKKLHLGKKILSMQKEAENEEKEIARKELGKERVEKEKECQTKEQLQEELPDVVLDPDTAHPELFLSEDRRSVRRGPSRQSVPDNPERFDCRPCVLGLESYSLGRHYWEVEVKNVMVWAVGVCRDNVERKGEALLVPQNGFWTLDMFENQYRALSSPEKILPLKEHLHRVGVFLDYEAGDVSFYNMKDRSHIYTCPRSPFSGPLRPFFRLGSDDSPLCICPSFRGAQGVTVPEGGLVLHRAETHHNHQFLGLRAR", "length": 526, "header": "tr|F1MZI6-1|F1MZI6_BOVIN Computationally mapped isoform of Butyrophilin subfamily 2 member A2 OS=Bos taurus OX=9913 GN=LOC107131749 PE=3 SV=4 CANONICAL=A0AAA9SD70-1" }, "locus": { "chromosome": "23", "start_pos": 31615030, "end_pos": 31605837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045031.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045031.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042458.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042458.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8851680", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8851680", "resource": "Reactome", "description": "Butyrophilin (BTN) family interactions" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" }, { "name": "negative regulation of activated T cell proliferation", "id": "GO:0046007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046007", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" }, { "name": "negative regulation of cytokine production", "id": "GO:0001818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001818", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SD70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 488, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SD70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD70" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 146, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SAS1-1", "uniprot_ac": "A0AAA9SAS1", "uniprot_id": "A0AAA9SAS1_BOVIN", "mass": { "chemical_mass": 49737.0, "monoisotopic_mass": 49737.0 }, "refseq": { "ac": "XP_005227160", "name": "carabin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227160" }, "gene_names": [ { "name": "TBC1D10C", "type": "recommended", "evidence": [ { "id": "A0AAA9SAS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1" } ] }, { "name": "TBC1D10C", "type": "synonym", "evidence": [ { "id": "XP_005227160", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227160" } ] } ], "protein_names": [ { "name": "Carabin", "type": "recommended", "evidence": [ { "id": "A0AAA9SAS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1/entry#names_and_taxonomy" } ] }, { "name": "TBC1 domain family member 10C", "type": "synonym", "evidence": [ { "id": "A0AAA9SAS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1/entry#names_and_taxonomy" } ] }, { "name": "carabin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005227160", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227160" } ] } ], "function": [ { "annotation": "Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1#function" }, { "database": "UniProtKB", "id": "ARBA00060117", "url": "https://www.uniprot.org/uniprotkb/ARBA00060117#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D10C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1", "locus": { "chromosome": "29", "start_pos": 45303135, "end_pos": 45297149, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013133", "url": "https://www.ensembl.org/id/ENSBTAG00000013133" } ] } } ], "crossref": [ { "id": "A0AAA9SAS1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SAS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "520599", "url": "https://www.ncbi.nlm.nih.gov/gene/520599", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227160", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227160", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQALGEDLAQPGELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSAAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQNLAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPRVHKHLQKVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGVKVLFRVGLTLVRLALGTTEQRLACPGLLETLGALRSIPPAQLQEEVFMPQVHGVALSEQDLQREIKAQLAQLPASASEPPPRPQARLPGAPAIFEAQQLAGTRGSPRPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRSRGPPIESPTRSHRSSTSFLDTRF", "length": 446, "header": "tr|A0AAA9SAS1-1|A0AAA9SAS1_BOVIN Isoform 1 of Carabin OS=Bos taurus OX=9913 GN=TBC1D10C PE=4 SV=2 CANONICAL=A0AAA9SAS1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1/entry#A0AAA9SAS1-1", "sequence": { "sequence": "MAQALGEDLAQPGELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSAAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQNLAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPRVHKHLQKVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGVKVLFRVGLTLVRLALGTTEQRLACPGLLETLGALRSIPPAQLQEEVFMPQVHGVALSEQDLQREIKAQLAQLPASASEPPPRPQARLPGAPAIFEAQQLAGTRGSPRPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRSRGPPIESPTRSHRSSTSFLDTRF", "length": 446, "header": "tr|A0AAA9SAS1-1|A0AAA9SAS1_BOVIN Isoform 1 of Carabin OS=Bos taurus OX=9913 GN=TBC1D10C PE=4 SV=2 CANONICAL=A0AAA9SAS1-1" }, "locus": { "chromosome": "29", "start_pos": 45302345, "end_pos": 45297179, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128859.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128859.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080554.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080554.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1" } ], "pmid": "" }, { "name": "filopodium membrane", "id": "GO:0031527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SAS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAS1" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 92, "end_pos": 280, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SBH6-1", "uniprot_ac": "A0AAA9SBH6", "uniprot_id": "A0AAA9SBH6_BOVIN", "mass": { "chemical_mass": 55604.0, "monoisotopic_mass": 55604.0 }, "refseq": {}, "gene_names": [ { "name": "DPYS", "type": "recommended", "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ] } ], "protein_names": [ { "name": "Dihydropyrimidinase", "type": "synonym", "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPYS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6", "locus": { "chromosome": "14", "start_pos": 60252851, "end_pos": 60148420, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021887", "url": "https://www.ensembl.org/id/ENSBTAG00000021887" } ] } } ], "crossref": [ { "id": "A0AAA9SBH6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SBH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021887", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021887", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01314", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01314", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BFN6", "url": "https://www.orthodb.org/?gene=E1BFN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11647", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11647", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11647:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11647:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-73621", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73621", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN6", "url": "https://www.uniprot.org/uniprotkb/E1BFN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARSLLLIRGGCVVNDDSSQEADVLVEDGVVQAVGRHVLPPGDAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSVDDFHLGTKAALAGGTTMIMDFAIPHKGHSLIEAFDTWRSWADSQVCCDYSLHVAVTWWSDQVKEEMKILTQDKGVNSFKMFMAYKDVYMVRDVELYEAFSRCKEIGAIAQVHAENGDLVAEGAKKMLALGITGPEGHELSRPEAVEAEATLRAVTIASAVNCPLYVVHVMSKSAAKVVADARRDGKVVYGEPIAAGLGTDGTHHWDREWLHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGSDNCTFNSCQKALGKDDFTKIPNGVNGVEDRMSIIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKATRTISAKTHHQAVNFNIFEGMVCHGVPVVTISRGKVVYEAGVFSVSAGDGKFIPRKPFAEYIYKRIKQQDQITEAASKDWLLTNPVETPFSELHKCHLR", "length": 509, "header": "tr|A0AAA9SBH6-1|A0AAA9SBH6_BOVIN Isoform 1 of Dihydropyrimidinase OS=Bos taurus OX=9913 GN=DPYS PE=1 SV=1 CANONICAL=A0AAA9SBH6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6/entry#A0AAA9SBH6-1", "sequence": { "sequence": "MAARSLLLIRGGCVVNDDSSQEADVLVEDGVVQAVGRHVLPPGDAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSVDDFHLGTKAALAGGTTMIMDFAIPHKGHSLIEAFDTWRSWADSQVCCDYSLHVAVTWWSDQVKEEMKILTQDKGVNSFKMFMAYKDVYMVRDVELYEAFSRCKEIGAIAQVHAENGDLVAEGAKKMLALGITGPEGHELSRPEAVEAEATLRAVTIASAVNCPLYVVHVMSKSAAKVVADARRDGKVVYGEPIAAGLGTDGTHHWDREWLHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGSDNCTFNSCQKALGKDDFTKIPNGVNGVEDRMSIIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKATRTISAKTHHQAVNFNIFEGMVCHGVPVVTISRGKVVYEAGVFSVSAGDGKFIPRKPFAEYIYKRIKQQDQITEAASKDWLLTNPVETPFSELHKCHLR", "length": 509, "header": "tr|A0AAA9SBH6-1|A0AAA9SBH6_BOVIN Isoform 1 of Dihydropyrimidinase OS=Bos taurus OX=9913 GN=DPYS PE=1 SV=1 CANONICAL=A0AAA9SBH6-1" }, "locus": { "chromosome": "14", "start_pos": 60251847, "end_pos": 60148730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094703.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094703.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080822.1" } ] } }, { "isoform_ac": "A0AAA9SUS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6/entry#A0AAA9SUS2-1", "sequence": { "sequence": "MAARSLLLIRGGCVVNDDSSQEADVLVEDGVVQAVGRHVLPPGDAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSVDDFHLGTKAALAGGTTMIMDFAIPHKGHSLIEAFDTWRSWADSQVCCDYSLHVAVTWWSDQVKEEMKILTQDKGVNSFKMFMAYKDVYMVRDVELYEAFSRCKEIGAIAQVHAENGDLVAEGAKKMLALGITGPEGHELSRPEAVEAEATLRAVTIASAVNCPLYVVHVMSKSAAKVVADARRDGKVVYGEPIAAGLGTDGTHHWDREWLHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGSDNCTFNSCQKALGKDDFTKIPNGVNGVEDRMSIIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKATRTISAKTHHQAVNFNIFEGMVCHGVPVVTISRGKVVYEAGVFSVSAGDGKFIPRKPFAEYIYKRIKQQDQAKIIL", "length": 486, "header": "tr|A0AAA9SUS2-1|A0AAA9SUS2_BOVIN Computationally mapped isoform of Dihydropyrimidinase OS=Bos taurus OX=9913 GN=DPYS PE=1 SV=1 CANONICAL=A0AAA9SBH6-1" }, "locus": { "chromosome": "14", "start_pos": 60229302, "end_pos": 60148730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109616.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109616.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086914.1" } ] } }, { "isoform_ac": "E1BFN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6/entry#E1BFN6-1", "sequence": { "sequence": "MDTPLLPAPPRPAAELINLDAGPRGCPQSPRRSAPLAMAARSLLLIRGGCVVNDDSSQEADVLVEDGVVQAVGRHVLPPGDAPAGLRVLDAAGKLVLPGGIDTHTHMQFPFMGSRSVDDFHLGTKAALAGGTTMIMDFAIPHKGHSLIEAFDTWRSWADSQVCCDYSLHVAVTWWSDQVKEEMKILTQDKGVNSFKMFMAYKDVYMVRDVELYEAFSRCKEIGAIAQVHAENGDLVAEGAKKMLALGITGPEGHELSRPEAVEAEATLRAVTIASAVNCPLYVVHVMSKSAAKVVADARRDGKVVYGEPIAAGLGTDGTHHWDREWLHAAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGSDNCTFNSCQKALGKDDFTKIPNGVNGVEDRMSIIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKATRTISAKTHHQAVNFNIFEGMVCHGVPVVTISRGKVVYEAGVFSVSAGDGKFIPRKPFAEYIYKRIKQQDQTCIPTPVKREPYKGEVITLTSKEDSTHGTRKQAQP", "length": 553, "header": "tr|E1BFN6-1|E1BFN6_BOVIN Computationally mapped isoform of Dihydropyrimidinase OS=Bos taurus OX=9913 GN=DPYS PE=1 SV=4 CANONICAL=A0AAA9SBH6-1" }, "locus": { "chromosome": "14", "start_pos": 60236414, "end_pos": 60148619, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029176.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029176.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029176.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029176.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 307, "start_aa": "Thr", "end_pos": 307, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr307", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-73621", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73621", "resource": "Reactome", "description": "Pyrimidine catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "id": "GO:0016810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016810", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "dihydropyrimidinase activity", "id": "GO:0004157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "dUMP catabolic process", "id": "GO:0046079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046079", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "pyrimidine nucleobase catabolic process", "id": "GO:0006208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006208", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "uracil catabolic process", "id": "GO:0006212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "CMP catabolic process", "id": "GO:0006248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006248", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "dCMP catabolic process", "id": "GO:0006249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" }, { "name": "UMP catabolic process", "id": "GO:0046050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PF01979", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01979" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amidohydrolase-related", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 447, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6#function" }, { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" } ], "binding_site_uniprot": 104, "amino_acid": "Pro", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 104, "end_pos": 104, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6#function" }, { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" } ], "binding_site_uniprot": 106, "amino_acid": "Lys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 106, "end_pos": 106, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6#function" }, { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2#function" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2" } ], "binding_site_uniprot": 159, "amino_acid": "Lys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "via carbamate group", "eco_id": "ECO_0000256", "start_pos": 159, "end_pos": 159, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6#function" }, { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2#function" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2" } ], "binding_site_uniprot": 192, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 192, "end_pos": 192, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6#function" }, { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" } ], "binding_site_uniprot": 196, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 196, "end_pos": 196, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6#function" }, { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" } ], "binding_site_uniprot": 229, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 229, "end_pos": 229, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6#function" }, { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2#function" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2" } ], "binding_site_uniprot": 248, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 248, "end_pos": 248, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6#function" }, { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" } ], "binding_site_uniprot": 285, "amino_acid": "Trp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 285, "end_pos": 285, "start_aa": "Trp", "end_aa": "Trp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6#function" }, { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2#function" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2" } ], "binding_site_uniprot": 326, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 326, "end_pos": 326, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6#function" }, { "id": "E1BFN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFN6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" } ], "binding_site_uniprot": 363, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 363, "end_pos": 363, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6#function" }, { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2#function" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2" } ], "binding_site_uniprot": 67, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 67, "end_pos": 67, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6#function" }, { "id": "A0AAA9SBH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH6" }, { "id": "PIRSR611778-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR611778-2" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2#function" }, { "id": "A0AAA9SUS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS2" } ], "binding_site_uniprot": 69, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 69, "end_pos": 69, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 307 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 327, "end_pos": 329 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SDY7-1", "uniprot_ac": "A0AAA9SDY7", "uniprot_id": "A0AAA9SDY7_BOVIN", "mass": { "chemical_mass": 26316.0, "monoisotopic_mass": 26316.0 }, "refseq": {}, "gene_names": [ { "name": "EGLN3", "type": "recommended", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ] } ], "protein_names": [ { "name": "hypoxia-inducible factor-proline dioxygenase", "type": "recommended", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7/entry#names_and_taxonomy" } ] }, { "name": "1.14.11.29", "type": "synonym", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EGLN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7", "locus": { "chromosome": "21", "start_pos": 44364995, "end_pos": 44416154, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008172", "url": "https://www.ensembl.org/id/ENSBTAG00000008172" } ] } } ], "crossref": [ { "id": "A0AAA9SDY7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SDY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006620", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006620", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12907", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12907", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12907:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12907:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "48400", "url": "https://www.rhea-db.org/rhea/48400", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCNGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAINYLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKRHGGVLRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTT", "length": 230, "header": "tr|A0AAA9SDY7-1|A0AAA9SDY7_BOVIN Isoform 1 of hypoxia-inducible factor-proline dioxygenase OS=Bos taurus OX=9913 GN=EGLN3 PE=4 SV=1 CANONICAL=A0AAA9SDY7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7/entry#A0AAA9SDY7-1", "sequence": { "sequence": "MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCNGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAINYLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKRHGGVLRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTT", "length": 230, "header": "tr|A0AAA9SDY7-1|A0AAA9SDY7_BOVIN Isoform 1 of hypoxia-inducible factor-proline dioxygenase OS=Bos taurus OX=9913 GN=EGLN3 PE=4 SV=1 CANONICAL=A0AAA9SDY7-1" }, "locus": { "chromosome": "21", "start_pos": 44415884, "end_pos": 44365055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112677.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112677.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083610.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ], "pmid": "" }, { "name": "L-ascorbic acid binding", "id": "GO:0031418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031418", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ], "pmid": "" }, { "name": "hypoxia-inducible factor-proline dioxygenase activity", "id": "GO:0160082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48400", "name": "", "equation": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0P3Q1-1", "A0AAA9SDY7-1", "A0A3Q1M2B6-1", "F1N3W9-1" ], "evidence": [ { "id": "48400", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48400" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M2B6", "gene_name": "EGLN1", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0A3Q1M2B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B6" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0A3Q1M2B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B6" } ] } ] }, { "uniprot_ac": "A0AAA9SDY7", "gene_name": "EGLN3", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" } ] } ] }, { "uniprot_ac": "A0ABI0P3Q1", "gene_name": "EGLN2", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0ABI0P3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3Q1" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0ABI0P3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3Q1" } ] } ] }, { "uniprot_ac": "F1N3W9", "gene_name": "P4HTM", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "F1N3W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SDY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY7" }, { "id": "PS51471", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51471" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fe2OG dioxygenase", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 214, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.11.29", "ec_name": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "1.14.11.29", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29" }, { "id": "1.14.11.29", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.11.29" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 227, "end_pos": 229 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH01-1", "uniprot_ac": "A0AAA9SH01", "uniprot_id": "A0AAA9SH01_BOVIN", "mass": { "chemical_mass": 113384.0, "monoisotopic_mass": 113384.0 }, "refseq": {}, "gene_names": [ { "name": "GLI1", "type": "recommended", "evidence": [ { "id": "A0AAA9SH01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ] } ], "protein_names": [ { "name": "GLI family zinc finger 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SH01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01", "locus": { "chromosome": "5", "start_pos": 55992686, "end_pos": 56003064, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006631", "url": "https://www.ensembl.org/id/ENSBTAG00000006631" } ] } } ], "crossref": [ { "id": "A0AAA9SH01", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH01", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFNSMTPPPVSSYGEPCCLRPLPSQGAPGMGTEVKLTKKRALSISPLSDTSLDLQTVIRTSPSSLVAFINSRCASPGGSYGHLSIGTMSPSLGFSPQMNHQKGTSPSFGVQPCGPHDPTQSGMMPHPQSRGPLPTCQLKSELGVLVNKCPEEPLEGDMSSPNSSSTQDPLLGMLDGREDLEREEKPEPDSVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPALSSVEPKRERDGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCLAGTGLSTLRRLENLRLDQLHQFRPMGPRGLKLPSLTHTGTPGSRRLGAPVSLDRRSSSSSSVSSAYTVSRRSSLASPFPPGSPPENGASSLPGLTPAQHYLLRARYASARGGGTPPTAAPSLDRTGALPAPPWRSRAEYPGYNPNVGVTRRASDPARSVDRPAPARVQRFKSLGCVHNTPTVVGGGQNFDPQLPTSVYSPQPPSITENVSMDTRGLREEPEVGTSMMGSGLNPYMDFPPADTLGYGGPEAAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQVPYSEPTPETWSEFPSHSGLYSGPKAPAGAYSQCPRLEHYGQVQVKPEQGCPVGSDATGLAPCLNAHPNEGPPRSQPLFSHYPQPPPPQYPQSGSYTQPPPDYLPSEARPSLDFESPTHSTGHLKAQLVCNYVQSQQELLWDSGGRGDPPVQEPLYQSPKFLGGSQVSPSPAKAPVATYGPGFAPNMPNHKPGSYPTPSCHENFAVGANKASHRAAAPPRLLPPLPACYGPLKAGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEAQGLSPPPSHNQRDSSEHTPPPSGTPNMAVGNMSVLLGSLPGETQFLNSSA", "length": 1064, "header": "tr|A0AAA9SH01-1|A0AAA9SH01_BOVIN Isoform 1 of GLI family zinc finger 1 OS=Bos taurus OX=9913 GN=GLI1 PE=3 SV=1 CANONICAL=A0AAA9SH01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01/entry#A0AAA9SH01-1", "sequence": { "sequence": "MFNSMTPPPVSSYGEPCCLRPLPSQGAPGMGTEVKLTKKRALSISPLSDTSLDLQTVIRTSPSSLVAFINSRCASPGGSYGHLSIGTMSPSLGFSPQMNHQKGTSPSFGVQPCGPHDPTQSGMMPHPQSRGPLPTCQLKSELGVLVNKCPEEPLEGDMSSPNSSSTQDPLLGMLDGREDLEREEKPEPDSVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPALSSVEPKRERDGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCLAGTGLSTLRRLENLRLDQLHQFRPMGPRGLKLPSLTHTGTPGSRRLGAPVSLDRRSSSSSSVSSAYTVSRRSSLASPFPPGSPPENGASSLPGLTPAQHYLLRARYASARGGGTPPTAAPSLDRTGALPAPPWRSRAEYPGYNPNVGVTRRASDPARSVDRPAPARVQRFKSLGCVHNTPTVVGGGQNFDPQLPTSVYSPQPPSITENVSMDTRGLREEPEVGTSMMGSGLNPYMDFPPADTLGYGGPEAAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQVPYSEPTPETWSEFPSHSGLYSGPKAPAGAYSQCPRLEHYGQVQVKPEQGCPVGSDATGLAPCLNAHPNEGPPRSQPLFSHYPQPPPPQYPQSGSYTQPPPDYLPSEARPSLDFESPTHSTGHLKAQLVCNYVQSQQELLWDSGGRGDPPVQEPLYQSPKFLGGSQVSPSPAKAPVATYGPGFAPNMPNHKPGSYPTPSCHENFAVGANKASHRAAAPPRLLPPLPACYGPLKAGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEAQGLSPPPSHNQRDSSEHTPPPSGTPNMAVGNMSVLLGSLPGETQFLNSSA", "length": 1064, "header": "tr|A0AAA9SH01-1|A0AAA9SH01_BOVIN Isoform 1 of GLI family zinc finger 1 OS=Bos taurus OX=9913 GN=GLI1 PE=3 SV=1 CANONICAL=A0AAA9SH01-1" }, "locus": { "chromosome": "5", "start_pos": 55999801, "end_pos": 55992878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102502.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102502.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083182.1" } ] } }, { "isoform_ac": "A0AAA9SLZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01/entry#A0AAA9SLZ4-1", "sequence": { "sequence": "MFNSMTPPPVSSYGEPCCLRPLPSQGAPGMGTEGLPGLPFCHQATLMPGPHSYGPAREANSCTEVPLFPPPRSAVKLTKKRALSISPLSDTSLDLQTVIRTSPSSLVAFINSRCASPGGSYGHLSIGTMSPSLGFSPQMNHQKGTSPSFGVQPCGPHDPTQSGMMPHPQSRGPLPTCQLKSELGVLVNKCPEEPLEGDMSSPNSSSTQDPLLGMLDGREDLEREEKPEPDSVYETDCRWDGCSQEFDSQEQLVHFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPALSSVEPKRERDGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCLAGTGLSTLRRLENLRLDQLHQFRPMGPRGLKLPSLTHTGTPGSRRLGAPVSLDRRSSSSSSVSSAYTVSRRSSLASPFPPGSPPENGASSLPGLTPAQHYLLRARYASARGGGTPPTAAPSLDRTGALPAPPWRSRAEYPGYNPNVGVTRRASDPARSVDRPAPARVQRFKSLGCVHNTPTVVGGGQNFDPQLPTSVYSPQPPSITENVSMDTRGLREEPEVGTSMMGSGLNPYMDFPPADTLGYGGPEAAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQVPYSEPTPETWSEFPSHSGLYSGPKAPAGAYSQCPRLEHYGQVQVKPEQGCPVGSDATGLAPCLNAHPNEGPPRSQPLFSHYPQPPPPQYPQSGSYTQPPPDYLPSEARPSLDFESPTHSTGHLKAQLVCNYVQSQQELLWDSGGRGDPPVQEPLYQSPKFLGGSQVSPSPAKAPVATYGPGFAPNMPNHKPGSYPTPSCHENFAVGANKASHRAAAPPRLLPPLPACYGPLKAGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEAQGLSPPPSHNQRDSSEHTPPPSGTPNMAVGNMSVLLGSLPGETQFLNSSA", "length": 1055, "header": "tr|A0AAA9SLZ4-1|A0AAA9SLZ4_BOVIN Computationally mapped isoform of GLI family zinc finger 1 OS=Bos taurus OX=9913 GN=GLI1 PE=3 SV=1 CANONICAL=A0AAA9SH01-1" }, "locus": { "chromosome": "5", "start_pos": 55999801, "end_pos": 55992878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087372.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087372.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 563, "start_aa": "Thr", "end_pos": 563, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr563", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 735, "start_aa": "Thr", "end_pos": 735, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr735", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 925, "start_aa": "Thr", "end_pos": 925, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr925", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1045, "end_pos": 1047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 654, "end_pos": 656, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH01" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 226, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 560, 563, 735, 925 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1045, "end_pos": 1047 }, { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 654, "end_pos": 656 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG65-1", "uniprot_ac": "A0AAA9SG65", "uniprot_id": "A0AAA9SG65_BOVIN", "mass": { "chemical_mass": 58579.0, "monoisotopic_mass": 58579.0 }, "refseq": {}, "gene_names": [ { "name": "WAS", "type": "recommended", "evidence": [ { "id": "A0AAA9SG65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ] } ], "protein_names": [ { "name": "Actin nucleation-promoting factor WAS", "type": "recommended", "evidence": [ { "id": "A0AAA9SG65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65#function" }, { "database": "UniProtKB", "id": "ARBA00058739", "url": "https://www.uniprot.org/uniprotkb/ARBA00058739#function" }, { "database": "UniProtKB", "id": "A0A3Q1NCB1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCB1#function" }, { "database": "UniProtKB", "id": "G3N3E1", "url": "https://www.uniprot.org/uniprotkb/G3N3E1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WAS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65", "locus": { "chromosome": "X", "start_pos": 86772976, "end_pos": 86760158, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046555", "url": "https://www.ensembl.org/id/ENSBTAG00000046555" } ] } } ], "crossref": [ { "id": "A0AAA9SG65", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046555", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046555", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00132", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00132", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01205", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01205", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000697", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NCB1", "url": "https://www.orthodb.org/?gene=A0A3Q1NCB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11202:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11202:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00568", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00568", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00786", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00786", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NCB1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCB1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3E1", "url": "https://www.uniprot.org/uniprotkb/G3N3E1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3E1-1", "url": "https://www.uniprot.org/uniprotkb/G3N3E1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSANLEGMERAGWHRVFPCRYMGMPDTTQICSAPLKLLAQPERTRAGGTMSGGPSGGRPGGRGGQGVQQNIPSTLLQDHENQQLFEMLGRKCWTLATAVVQLYLALPPGAEHWTKGHCGAVCFVKDNPKKSYFIRLYGLQAGRLLWEQELYSQLVYSAPTPFFHTFAGDDCQAGLNFANEGEAEAFRNLVQEKIQKRNQRQSGDRRQLPPPPVPVSEERRGGLPPLPPHPGGDQGGPAASPVSLGLVTVDIQNPDITNSRYRSLPAPGPSPSDKKRSGKKKISKSDIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISDAQLTDAETSKFIYDFIENQGGMEAVRKEMRRQEPLPPPPPPSRGGNQPPRPPTVGSNKGRSGPLPPVPSGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSVPPPPPPPGAGGGPPMPPPPPPPPPPPPPSSGDGPIPPPTPPSLGLVGGPAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSKAIHSSDEGEDQAGDDDDDDEWDD", "length": 555, "header": "tr|A0AAA9SG65-1|A0AAA9SG65_BOVIN Isoform 1 of Actin nucleation-promoting factor WAS OS=Bos taurus OX=9913 GN=WAS PE=4 SV=1 CANONICAL=A0AAA9SG65-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NCB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65/entry#A0A3Q1NCB1-1", "sequence": { "sequence": "MSSANLEGMERAGWHRVFPCRAQPERTRAGGTMSGGPSGGRPGGRGGQGVQQNIPSTLLQDHENQQLFEMLGRKCWTLATAVVQLYLALPPGAEHWTKGHCGAVCFVKDNPKKSYFIRLYGLQAGRLLWEQELYSQLVYSAPTPFFHTFAGDDCQAGLNFANEGEAEAFRNLVQEKIQKRNQRQSGDRRQLPPPPVPVSEERRGGLPPLPPHPGGDQGGPAASPVSLGLVTVDIQNPDITNSRYRSLPAPGPSPSDKKRSGKKKISKSDIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISDAQLTDAETSKFIYDFIENQGGMEAVRKEMRRQEPLPPPPPPSRGGNQPPRPPTVGSNKGRSGPLPPVPSGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSVPPPPPPPGAGGGPPMPPPPPPPPPPPPPSSGDGPIPPPTPPSLGLVGGPAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSKAIHSSDEGEDQAGDDDDDDEWDD", "length": 537, "header": "tr|A0A3Q1NCB1-1|A0AAA9SG65_BOVIN Computationally mapped isoform of Actin nucleation-promoting factor WAS OS=Bos taurus OX=9913 GN=WAS PE=4 SV=2 CANONICAL=A0AAA9SG65-1" }, "locus": { "chromosome": "X", "start_pos": 86772517, "end_pos": 86760610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068210.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068210.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069006.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069006.2" } ] } }, { "isoform_ac": "A0AAA9SG65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65/entry#A0AAA9SG65-1", "sequence": { "sequence": "MSSANLEGMERAGWHRVFPCRYMGMPDTTQICSAPLKLLAQPERTRAGGTMSGGPSGGRPGGRGGQGVQQNIPSTLLQDHENQQLFEMLGRKCWTLATAVVQLYLALPPGAEHWTKGHCGAVCFVKDNPKKSYFIRLYGLQAGRLLWEQELYSQLVYSAPTPFFHTFAGDDCQAGLNFANEGEAEAFRNLVQEKIQKRNQRQSGDRRQLPPPPVPVSEERRGGLPPLPPHPGGDQGGPAASPVSLGLVTVDIQNPDITNSRYRSLPAPGPSPSDKKRSGKKKISKSDIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISDAQLTDAETSKFIYDFIENQGGMEAVRKEMRRQEPLPPPPPPSRGGNQPPRPPTVGSNKGRSGPLPPVPSGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSVPPPPPPPGAGGGPPMPPPPPPPPPPPPPSSGDGPIPPPTPPSLGLVGGPAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSKAIHSSDEGEDQAGDDDDDDEWDD", "length": 555, "header": "tr|A0AAA9SG65-1|A0AAA9SG65_BOVIN Isoform 1 of Actin nucleation-promoting factor WAS OS=Bos taurus OX=9913 GN=WAS PE=4 SV=1 CANONICAL=A0AAA9SG65-1" }, "locus": { "chromosome": "X", "start_pos": 86772517, "end_pos": 86760610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096563.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096563.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085157.1" } ] } }, { "isoform_ac": "A0AAA9SH61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65/entry#A0AAA9SH61-1", "sequence": { "sequence": "MSGGPSGGRPGGRGGQGVQQNIPSTLLQDHENQQLFEMLGRKCWTLATAVVQLYLALPPGAEHWTKGHCGAVCFVKDNPKKSYFIRLYGLQAGRLLWEQELYSQLVYSAPTPFFHTFAGDDCQAGLNFANEGEAEAFRNLVQEKIQKRNQRQSGDRRQLPPPPVPVSEERRGGLPPLPPHPGGDQGGPAASPVSLGLVTVDIQNPDITNSRYRSLPAPGPSPSDKKRSGKKKISKSDIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISDAQLTDAETSKFIYDFIENQGGMEAVRKEMRRQEPLPPPPPPSRGGNQPPRPPTVGSNKGRSGPLPPVPSGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSVPPPPPPPGAGGGPPMPPPPPPPPPPPPPSSGDGPIPPPTPPSLGLVGGPAPGGGRGALLDQIRQGIQLNKTKGRTRPGMMMMMMNGTTESPPPLLFCAGLPWQPSSPPST", "length": 489, "header": "tr|A0AAA9SH61-1|A0AAA9SH61_BOVIN Computationally mapped isoform of WASP actin nucleation promoting factor OS=Bos taurus OX=9913 GN=WAS PE=4 SV=1 CANONICAL=A0AAA9SG65-1" }, "locus": { "chromosome": "X", "start_pos": 86772584, "end_pos": 86765550, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107207.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107207.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083251.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083251.1" } ] } }, { "isoform_ac": "G3N3E1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65/entry#G3N3E1-1", "sequence": { "sequence": "MLSSPQAADHENQQLFEMLGRKCWTLATAVVQLYLALPPGAEHWTKGHCGAVCFVKDNPKKSYFIRLYGLQAGRLLWEQELYSQLVYSAPTPFFHTFAGDDCQAGLNFANEGEAEAFRNLVQEKIQKRNQRQSGDRRQLPPPPVPVSEERRGGLPPLPPHPGGDQGGPAASPVSLGLVTVDIQNPDITNSRYRSLPAPGPSPSDKKRSGKKKISKSDIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISDAQLTDAETSKFIYDFIENQGGMEAVRKEMRRQEPLPPPPPPSRGGNQPPRPPTVGSNKGRSGPLPPVPSGGAPPPPTPRGPPPPGRGGPPPPPPPATGRSVPPPPPPPGAGGGPPMPPPPPPPPPPPPPSSGDGPIPPPTPPSLGLVGGPAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSKAIHSSDEGEDQAGDDDDDDEWDD", "length": 485, "header": "tr|G3N3E1-1|G3N3E1_BOVIN Computationally mapped isoform of Actin nucleation-promoting factor WAS OS=Bos taurus OX=9913 GN=WAS PE=4 SV=4 CANONICAL=A0AAA9SG65-1" }, "locus": { "chromosome": "X", "start_pos": 86772517, "end_pos": 86763863, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000062988.4", "url": "https://www.ensembl.org/id/ENSBTAT00000062988.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056444.4", "url": "https://www.ensembl.org/id/ENSBTAP00000056444.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 405, "start_aa": "Thr", "end_pos": 405, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr405", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 468, "start_aa": "Thr", "end_pos": 468, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr468", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "phospholipase binding", "id": "GO:0043274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043274", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "vesicle membrane", "id": "GO:0012506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "actin filament polymerization", "id": "GO:0030041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "regulation of actin polymerization or depolymerization", "id": "GO:0008064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "negative regulation of cell motility", "id": "GO:2000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "negative regulation of stress fiber assembly", "id": "GO:0051497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "regulation of lamellipodium assembly", "id": "GO:0010591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "Cdc42 protein signal transduction", "id": "GO:0032488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032488", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via homologous recombination", "id": "GO:1905168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "regulation of T cell antigen processing and presentation", "id": "GO:0002625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" }, { "id": "PS50108", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRIB", "eco_id": "ECO_0000259", "start_pos": 288, "end_pos": 301, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SG65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" }, { "id": "PS50229", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50229" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WH1", "eco_id": "ECO_0000259", "start_pos": 89, "end_pos": 198, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SG65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG65" }, { "id": "PS51082", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WH2", "eco_id": "ECO_0000259", "start_pos": 483, "end_pos": 500, "start_aa": "Gly", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 405, 468 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 498, "end_pos": 500 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI04-1", "uniprot_ac": "A0AAA9SI04", "uniprot_id": "A0AAA9SI04_BOVIN", "mass": { "chemical_mass": 8808.0, "monoisotopic_mass": 8808.0 }, "refseq": { "ac": "XP_003585848", "name": "MICOS complex subunit MIC10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585848" }, "gene_names": [ { "name": "MICOS10", "type": "recommended", "evidence": [ { "id": "A0AAA9SI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04" } ] }, { "name": "MICOS10", "type": "synonym", "evidence": [ { "id": "XP_003585848", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585848" } ] } ], "protein_names": [ { "name": "MICOS complex subunit MIC10", "type": "recommended", "evidence": [ { "id": "A0AAA9SI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04/entry#names_and_taxonomy" } ] }, { "name": "MICOS complex subunit MIC10", "type": "synonym", "evidence": [ { "id": "XP_003585848", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585848" } ] } ], "function": [ { "annotation": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NE13", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE13#function" }, { "database": "UniProtKB", "id": "RU363011", "url": "https://www.uniprot.org/uniprotkb/RU363011#function" }, { "database": "UniProtKB", "id": "ARBA00002689", "url": "https://www.uniprot.org/uniprotkb/ARBA00002689#function" }, { "database": "UniProtKB", "id": "A0AAA9SI04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04#function" }, { "database": "UniProtKB", "id": "A0A3Q1LSN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSN3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MICOS10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04", "locus": {} } ], "crossref": [ { "id": "A0AAA9SI04", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508331", "url": "https://www.ncbi.nlm.nih.gov/gene/508331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007512", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007512", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR21304", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21304", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21304:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21304:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04418", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04418", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003585848", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585848", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NE13", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NE13-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSESELGRKWDRCLADAVVKIGTGFGLGLVFSLTLFKRRMWPLAFGSGMGFGMAYSNCQHDFQAPYLLHGKYVKEQEQ", "length": 78, "header": "tr|A0AAA9SI04-1|A0AAA9SI04_BOVIN Isoform 1 of MICOS complex subunit MIC10 OS=Bos taurus OX=9913 GN=MICOS10 PE=3 SV=2 CANONICAL=A0AAA9SI04-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04/entry#A0A3Q1LSN3-1", "sequence": { "sequence": "MSESELGRKWDRCLADAVVKIGRMWPLAFGSGMGFGMAYSNCQHDFQAPYLLHGKYVKEQEQ", "length": 62, "header": "tr|A0A3Q1LSN3-1|A0A3Q1LSN3_BOVIN Computationally mapped isoform of MICOS complex subunit MIC10 OS=Bos taurus OX=9913 GN=MICOS10 PE=3 SV=2 CANONICAL=A0AAA9SI04-1" }, "locus": { "chromosome": "2", "start_pos": 133110076, "end_pos": 133072366, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070896.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070896.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058093.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058093.2" } ] } }, { "isoform_ac": "A0A3Q1NE13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04/entry#A0A3Q1NE13-1", "sequence": { "sequence": "MWPLAFGSGMGFGMAYSNCQHDFQAPYLLHGKYVKEQEQ", "length": 39, "header": "tr|A0A3Q1NE13-1|A0AAA9SI04_BOVIN Computationally mapped isoform of MICOS complex subunit MIC10 OS=Bos taurus OX=9913 GN=MICOS10 PE=3 SV=2 CANONICAL=A0AAA9SI04-1" }, "locus": { "chromosome": "2", "start_pos": 133074417, "end_pos": 133072366, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076233.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076233.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069792.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069792.2" } ] } }, { "isoform_ac": "A0AAA9SI04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04/entry#A0AAA9SI04-1", "sequence": { "sequence": "MSESELGRKWDRCLADAVVKIGTGFGLGLVFSLTLFKRRMWPLAFGSGMGFGMAYSNCQHDFQAPYLLHGKYVKEQEQ", "length": 78, "header": "tr|A0AAA9SI04-1|A0AAA9SI04_BOVIN Isoform 1 of MICOS complex subunit MIC10 OS=Bos taurus OX=9913 GN=MICOS10 PE=3 SV=2 CANONICAL=A0AAA9SI04-1" }, "locus": { "chromosome": "2", "start_pos": 133110076, "end_pos": 133072366, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106101.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106101.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083377.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083377.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508331", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04" } ], "pmid": "" }, { "name": "MICOS complex", "id": "GO:0061617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061617", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cristae formation", "id": "GO:0042407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042407", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEK8-1", "uniprot_ac": "A0AAA9SEK8", "uniprot_id": "A0AAA9SEK8_BOVIN", "mass": { "chemical_mass": 74887.0, "monoisotopic_mass": 74887.0 }, "refseq": { "ac": "NP_001193114", "name": "semaphorin-7A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193114" }, "gene_names": [ { "name": "SEMA7A", "type": "recommended", "evidence": [ { "id": "A0AAA9SEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ] }, { "name": "SEMA7A", "type": "synonym", "evidence": [ { "id": "NP_001193114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193114" } ] } ], "protein_names": [ { "name": "Semaphorin-7A", "type": "recommended", "evidence": [ { "id": "A0AAA9SEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#names_and_taxonomy" } ] }, { "name": "Semaphorin-K1", "type": "synonym", "evidence": [ { "id": "A0AAA9SEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#names_and_taxonomy" } ] }, { "name": "Semaphorin-L", "type": "synonym", "evidence": [ { "id": "A0AAA9SEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#names_and_taxonomy" } ] }, { "name": "semaphorin 7A (John Milton Hagen blood group)", "type": "synonym", "evidence": [ { "id": "NP_001193114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193114" } ] }, { "name": "semaphorin-7A precursor", "type": "synonym", "evidence": [ { "id": "NP_001193114", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193114" } ] } ], "function": [ { "annotation": "Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.", "evidence": [ { "database": "UniProtKB", "id": "E1BNR9", "url": "https://www.uniprot.org/uniprotkb/E1BNR9#function" }, { "database": "UniProtKB", "id": "ARBA00059710", "url": "https://www.uniprot.org/uniprotkb/ARBA00059710#function" }, { "database": "UniProtKB", "id": "A0A3Q1NI92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NI92#function" }, { "database": "UniProtKB", "id": "A0AAA9ST50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST50#function" }, { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEMA7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8", "locus": { "chromosome": "21", "start_pos": 34257979, "end_pos": 34233524, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011446", "url": "https://www.ensembl.org/id/ENSBTAG00000011446" } ] } } ], "crossref": [ { "id": "A0AAA9SEK8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011446", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011446", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11243", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11243", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614707", "url": "https://www.ncbi.nlm.nih.gov/gene/614707", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614707", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614707", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYHMGLP", "url": "https://omabrowser.org/oma/group/GYHMGLP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NI92", "url": "https://www.orthodb.org/?gene=A0A3Q1NI92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BNR9", "url": "https://www.orthodb.org/?gene=E1BNR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF80", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF80", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416700", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193114", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NI92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NI92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NI92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NI92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNR9", "url": "https://www.uniprot.org/uniprotkb/E1BNR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNR9-1", "url": "https://www.uniprot.org/uniprotkb/E1BNR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPPPSRCTALGAPRARVSSSLARSRFPLWLLLQLVWTAAASQGHSKSGPRISAVWKGRAGQDHVDFGSTEPHTVLFHEPGSSSVWVGGRNRIYVFAFSKGRNASVRTVNIGSTKGSCRDKQDCGNYITLLEKQNEGLLACGTNARRPSCWILVNDSVEFLGERKGYAPFSPDENSLVLFDGDEVYSTIRKQEYNGKIPRFRRIKGEIELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDATTNKNFNRLQDVFLLPDPNGQWKDTRVYGVFSNPWNYSAVCVYSLGDIDKVFCTSSLKGYHSSLPNPRPGKCLPDRQPIPTETFQVADSHPEVVQRVEPMGPLKAPLFHSKYHYQKVVVHRMHASNGETFHVLYLTTDKGTIHKVLEPGEWEHGLVFNILEIQPFRRAAAIQAMSLDADRRKLYVNSQWEVSQVPLDLCELYTGGCHGCLMARDPYCGWYQDRCVSIYSSQEPVLQSISPVDPHKGCPNPKPEQAPLQKVSLAQNSRYYLSCPMESRHATYSWRHENSVEQSCEPGHQSPNCILFIENLTDLHYGHYYCEAQEDSYLREAQHWELLREDSAMTSQLLGHACTLATSLWLGVLPTLILGLLVH", "length": 664, "header": "tr|A0AAA9SEK8-1|A0AAA9SEK8_BOVIN Isoform 1 of Semaphorin-7A OS=Bos taurus OX=9913 GN=SEMA7A PE=3 SV=1 CANONICAL=A0AAA9SEK8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NI92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#A0A3Q1NI92-1", "sequence": { "sequence": "MAKGNLWSSSLVPGTPQARQTLPSTCPPGPPAGNGRAGQDHVDFGSTEPHTVLFHEPGSSSVWVGGRNRIYVFAFSKGRNASVRTVNIGSTKGSCRDKQDCGNYITLLEKQNEGLLACGTNARRPSCWILVNDSVEFLGERKGYAPFSPDENSLVLFDGDEVYSTIRKQEYNGKIPRFRRIKGEIELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDATTNKNFNRLQDVFLLPDPNGQWKDTRVYGVFSNPWNYSAVCVYSLGDIDKVFCTSSLKGYHSSLPNPRPGKCLPDRQPIPTETFQVADSHPEVVQRVEPMGPLKAPLFHSKYHYQKVVVHRMHASNGETFHVLYLTTDKGTIHKVLEPGEWEHGLVFNILEIQPFRRAAAIQAMSLDADRRKLYVNSQWEVSQVPLDLCELYTGGCHGCLMARDPYCGWYQDRCVSIYSSQEPVLQSISPVDPHKGCPNPKPEQAPLQKVSLAQNSRYYLSCPMESRHATYSWRHENSVEQSCEPGHQSPNCILFIENLTDLHYGHYYCEAQEDSYLREAQHWELLREDSAMTSQLLGHACTLATSLWLGVLPTLILGLLVH", "length": 641, "header": "tr|A0A3Q1NI92-1|A0AAA9SEK8_BOVIN Computationally mapped isoform of Semaphorin-7A OS=Bos taurus OX=9913 GN=SEMA7A PE=3 SV=2 CANONICAL=A0AAA9SEK8-1" }, "locus": { "chromosome": "21", "start_pos": 34257477, "end_pos": 34236927, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075816.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075816.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071718.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071718.2" } ] } }, { "isoform_ac": "A0AAA9SEK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#A0AAA9SEK8-1", "sequence": { "sequence": "MTPPPSRCTALGAPRARVSSSLARSRFPLWLLLQLVWTAAASQGHSKSGPRISAVWKGRAGQDHVDFGSTEPHTVLFHEPGSSSVWVGGRNRIYVFAFSKGRNASVRTVNIGSTKGSCRDKQDCGNYITLLEKQNEGLLACGTNARRPSCWILVNDSVEFLGERKGYAPFSPDENSLVLFDGDEVYSTIRKQEYNGKIPRFRRIKGEIELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDATTNKNFNRLQDVFLLPDPNGQWKDTRVYGVFSNPWNYSAVCVYSLGDIDKVFCTSSLKGYHSSLPNPRPGKCLPDRQPIPTETFQVADSHPEVVQRVEPMGPLKAPLFHSKYHYQKVVVHRMHASNGETFHVLYLTTDKGTIHKVLEPGEWEHGLVFNILEIQPFRRAAAIQAMSLDADRRKLYVNSQWEVSQVPLDLCELYTGGCHGCLMARDPYCGWYQDRCVSIYSSQEPVLQSISPVDPHKGCPNPKPEQAPLQKVSLAQNSRYYLSCPMESRHATYSWRHENSVEQSCEPGHQSPNCILFIENLTDLHYGHYYCEAQEDSYLREAQHWELLREDSAMTSQLLGHACTLATSLWLGVLPTLILGLLVH", "length": 664, "header": "tr|A0AAA9SEK8-1|A0AAA9SEK8_BOVIN Isoform 1 of Semaphorin-7A OS=Bos taurus OX=9913 GN=SEMA7A PE=3 SV=1 CANONICAL=A0AAA9SEK8-1" }, "locus": { "chromosome": "21", "start_pos": 34257477, "end_pos": 34234871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115933.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115933.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080834.1" } ] } }, { "isoform_ac": "A0AAA9ST50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#A0AAA9ST50-1", "sequence": { "sequence": "MGFLEALLPEGGGGRAGQDHVDFGSTEPHTVLFHEPGSSSVWVGGRNRIYVFAFSKGRNASVRTVNIGSTKGSCRDKQDCGNYITLLEKQNEGLLACGTNARRPSCWILVNDSVEFLGERKGYAPFSPDENSLVLFDGDEVYSTIRKQEYNGKIPRFRRIKGEIELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDATTNKNFNRLQDVFLLPDPNGQWKDTRVYGVFSNPWNYSAVCVYSLGDIDKVFCTSSLKGYHSSLPNPRPGKCLPDRQPIPTETFQVADSHPEVVQRVEPMGPLKAPLFHSKYHYQKVVVHRMHASNGETFHVLYLTTDKGTIHKVLEPGEWEHGLVFNILEIQPFRRAAAIQAMSLDADRRKLYVNSQWEVSQVPLDLCELYTGGCHGCLMARDPYCGWYQDRCVSIYSSQEPVLQSISPVDPHKGCPNPKPEQAPLQKVSLAQNSRYYLSCPMESRHATYSWRHENSVEQSCEPGHQSPNCILFIENLTDLHYGHYYCEAQEDSYLREAQHWELLREDSAMTSQLLGHACTLATSLWLGVLPTLILGLLVH", "length": 620, "header": "tr|A0AAA9ST50-1|A0AAA9ST50_BOVIN Computationally mapped isoform of Semaphorin-7A OS=Bos taurus OX=9913 GN=SEMA7A PE=3 SV=1 CANONICAL=A0AAA9SEK8-1" }, "locus": { "chromosome": "21", "start_pos": 34257477, "end_pos": 34248104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132917.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132917.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086212.1" } ] } }, { "isoform_ac": "E1BNR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8/entry#E1BNR9-1", "sequence": { "sequence": "MGKLRPEKPGLAQHHPVRWAEPGPGRAGQDHVDFGSTEPHTVLFHEPGSSSVWVGGRNRIYVFAFSKGRNASVRTVNIGSTKGSCRDKQDCGNYITLLEKQNEGLLACGTNARRPSCWILVNDSVEFLGERKGYAPFSPDENSLVLFDGDEVYSTIRKQEYNGKIPRFRRIKGEIELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDATTNKNFNRLQDVFLLPDPNGQWKDTRVYGVFSNPWNYSAVCVYSLGDIDKVFCTSSLKGYHSSLPNPRPGKCLPDRQPIPTETFQVADSHPEVVQRVEPMGPLKAPLFHSKYHYQKVVVHRMHASNGETFHVLYLTTDKGTIHKVLEPGEWEHGLVFNILEIQPFRRAAAIQAMSLDADRRKLYVNSQWEVSQVPLDLCELYTGGCHGCLMARDPYCGWYQDRCVSIYSSQEPVLQSISPVDPHKGCPNPKPEQAPLQKVSLAQNSRYYLSCPMESRHATYSWRHENSVEQSCEPGHQSPNCILFIENLTDLHYGHYYCEAQEDSYLREAQHWELLREDSAMTSQLLGHACTLATSLWLGVLPTLILGLLVH", "length": 631, "header": "tr|E1BNR9-1|E1BNR9_BOVIN Computationally mapped isoform of Semaphorin-7A OS=Bos taurus OX=9913 GN=SEMA7A PE=3 SV=3 CANONICAL=A0AAA9SEK8-1" }, "locus": { "chromosome": "21", "start_pos": 34257477, "end_pos": 34240508, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015210.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015210.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015210.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015210.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614707", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614707", "resource": "KEGG Pathway" }, { "id": "R-BTA-416700", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416700", "resource": "Reactome", "description": "Other semaphorin interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQP6-1", "protein_name": "Semaphorin-7A", "gene_name": "Sema7a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVTAASAQGHSRSGPRISAVWKGQDHVDFGQPEPHNVLFHEPGSFSVWVGGRGKVYLFNFPEGKNASVRTVNIGSTKGSCQDKQDCENYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMSLGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQEHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSPWEVSQVPLDMCGVYSGGCHGCLMSRDPYCGWDQDQDRCVSIYSSQRSVLQSINPAEPHRECPNPNPDEAPLQKVSLARNSRYYLTCPMESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLHEAQHWELLPEDRALAEQLLGHARALAASFWLGVLPTLVLGLLVH", "length": 666 }, "evidence": [ { "id": "A0AAA9SEK8", "url": "https://omabrowser.org/oma/group/A0AAA9SEK8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FBE1-1", "protein_name": "Semaphorin-7A isoform 1 precursor", "gene_name": "sema7a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MIRHYSSLKFKGNLAYPWLIYGACFQCVFCSCNPRLTLKQDNAPLNYNTNYSHTVLFHEEGSKSLFVGGSNIVLHFDVDSYEILENFTLNANLPRCGESSCENVVTVIETFQNCKFVCGTNGEEPQCWELYPRESNHSVVKSVEGTGISPHSSEQNSLSLVADGDLYAAAPLYSDGTLLQFRRKAGKRINVWMHDQWVSEPTFISSFLAKRKNDSLNEKIYVLFREKNSDTSPEADPWISRVARVCKIDEGGSKQFLQNIWTSFLKARLVCGIPKESLYFNRLQDVFVQHAEDWRDSLVYALFSSSWNSTAVCIYSLADLDDIFEKSNYKGFSEAIPNPRPGKCVENSNSLPIPTLKIIKDYPEMKDWIHPIQKDTPFFTSSKNFTKIVVDQIRALDENVYNVLLLATDDGMIFKILQHGSKPFIISETHLCNGCAPIQSMKLDSKKRKLFVGYPGQMSVLELQRCQDYGASCEECVLSRDPYCAWSEKGCTSQTRGGIQNISDGNVTKVCDHKSVGRVRRDAQQSSTAPSRIQHTVATDVPFYLSCPVDSHHASYRWEHGGKSNPCQQTQSEYLLLIPAMTAENYGNYSCVSQERDYIKVVREYELLAKSVFNDAFKLKIQDRQLMVAFVTSAFYLCSL", "length": 640 }, "evidence": [ { "id": "A0AAA9SEK8", "url": "https://omabrowser.org/oma/group/A0AAA9SEK8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O75326-1", "protein_name": "Semaphorin-7A", "gene_name": "SEMA7A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH", "length": 666 }, "evidence": [ { "id": "A0AAA9SEK8", "url": "https://omabrowser.org/oma/group/A0AAA9SEK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QUR8-1", "protein_name": "Semaphorin-7A", "gene_name": "Sema7a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVAAASAQGHSRSGPRISAVWKGQDHVDFSQPEPHTVLFHEPGSFSVWVGGRGKVYHFNFPEGKNASVRTVNIGSTKGSCQDKQDCGNYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMSLGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQDHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQVPLDMCEVYSGGCHGCLMSRDPYCGWDQDRCVSIYSSQRSVLQSINPAEPHRECPNPKPDEAPLQKVSLARNSRYYLTCPMESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLREAQHWELLPEDRALAEQLMGHARALAASFWLGVLPTLILGLLVH", "length": 664 }, "evidence": [ { "id": "A0AAA9SEK8", "url": "https://omabrowser.org/oma/group/A0AAA9SEK8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "positive regulation of axon extension", "id": "GO:0045773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045773", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "positive regulation of macrophage cytokine production", "id": "GO:0060907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060907", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "regulation of synapse maturation", "id": "GO:0090128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090128", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 542, "end_pos": 617, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SEK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK8" }, { "id": "PS51004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sema", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 488, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 328, "end_pos": 330 }, { "start_pos": 600, "end_pos": 602 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI49-1", "uniprot_ac": "A0AAA9SI49", "uniprot_id": "A0AAA9SI49_BOVIN", "mass": { "chemical_mass": 59385.0, "monoisotopic_mass": 59385.0 }, "refseq": {}, "gene_names": [ { "name": "KPNA3", "type": "recommended", "evidence": [ { "id": "A0AAA9SI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ] }, { "name": "KPNA4", "type": "recommended", "evidence": [ { "id": "A0AAA9SI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ] }, { "name": "KPNA4", "type": "synonym", "evidence": [ { "id": "A0AAA9SI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ] } ], "protein_names": [ { "name": "Importin subunit alpha", "type": "recommended", "evidence": [ { "id": "A0AAA9SI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Functions in nuclear protein import.", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ9", "url": "https://www.uniprot.org/uniprotkb/F1MIZ9#function" }, { "database": "UniProtKB", "id": "PIRNR005673", "url": "https://www.uniprot.org/uniprotkb/PIRNR005673#function" }, { "database": "UniProtKB", "id": "ARBA00053483", "url": "https://www.uniprot.org/uniprotkb/ARBA00053483#function" }, { "database": "UniProtKB", "id": "A0A3Q1MUS6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUS6#function" }, { "database": "UniProtKB", "id": "A0A3Q1NKI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKI3#function" }, { "database": "UniProtKB", "id": "A0AAA9S9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9C3#function" }, { "database": "UniProtKB", "id": "A0ABI0NR78", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR78#function" }, { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KPNA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49", "locus": { "chromosome": "1", "start_pos": 106986403, "end_pos": 106924857, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017416", "url": "https://www.ensembl.org/id/ENSBTAG00000017416" } ] } } ], "crossref": [ { "id": "A0AAA9SI49", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004850", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004850", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540719", "url": "https://www.ncbi.nlm.nih.gov/gene/540719", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540719", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540719", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GGNEHIQ", "url": "https://omabrowser.org/oma/group/GGNEHIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUS6", "url": "https://www.orthodb.org/?gene=A0A3Q1MUS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKI3", "url": "https://www.orthodb.org/?gene=A0A3Q1NKI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MIZ9", "url": "https://www.orthodb.org/?gene=F1MIZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23316", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23316", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01749", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01749", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MUS6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUS6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NR78", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NR78-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ9", "url": "https://www.uniprot.org/uniprotkb/F1MIZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKVIKRSSQMMYKMNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF", "length": 533, "header": "tr|A0AAA9SI49-1|A0AAA9SI49_BOVIN Isoform 1 of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA4 PE=3 SV=1 CANONICAL=A0AAA9SI49-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#A0A3Q1MUS6-1", "sequence": { "sequence": "MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTANLQTKEFNF", "length": 478, "header": "tr|A0A3Q1MUS6-1|A0A3Q1MUS6_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA3 PE=3 SV=2 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "12", "start_pos": 19339379, "end_pos": 19244040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072923.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072923.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074403.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074403.2" } ] } }, { "isoform_ac": "A0A3Q1NKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#A0A3Q1NKI3-1", "sequence": { "sequence": "MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTANLQTKEFNF", "length": 521, "header": "tr|A0A3Q1NKI3-1|A0AAA9SI49_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA4 PE=3 SV=2 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "12", "start_pos": 19339379, "end_pos": 19244040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080687.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080687.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072854.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072854.2" } ] } }, { "isoform_ac": "A0AAA9S9C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#A0AAA9S9C3-1", "sequence": { "sequence": "MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF", "length": 477, "header": "tr|A0AAA9S9C3-1|A0AAA9SI49_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA4 PE=3 SV=1 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "1", "start_pos": 106985399, "end_pos": 106925312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113587.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113587.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079995.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079995.1" } ] } }, { "isoform_ac": "A0AAA9SI49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#A0AAA9SI49-1", "sequence": { "sequence": "MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKVIKRSSQMMYKMNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF", "length": 533, "header": "tr|A0AAA9SI49-1|A0AAA9SI49_BOVIN Isoform 1 of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA4 PE=3 SV=1 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "1", "start_pos": 106985399, "end_pos": 106925312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095452.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095452.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083418.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083418.1" } ] } }, { "isoform_ac": "A0AAA9TUW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#A0AAA9TUW3-1", "sequence": { "sequence": "MADNEKLDNQRLKNFKNKGRDLEDNFSVEKNTPGVRGLPGDANSAFQRPVFYCGYS", "length": 56, "header": "tr|A0AAA9TUW3-1|A0AAA9TUW3_BOVIN Computationally mapped isoform of Karyopherin subunit alpha 4 OS=Bos taurus OX=9913 GN=KPNA4 PE=4 SV=2 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "1", "start_pos": 106926048, "end_pos": 106925312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121010.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121010.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100371.2", "url": "https://www.ensembl.org/id/ENSBTAP00000100371.2" } ] } }, { "isoform_ac": "A0ABI0NR78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#A0ABI0NR78-1", "sequence": { "sequence": "MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDVFNNLIIFLVLLNKHKSG", "length": 472, "header": "tr|A0ABI0NR78-1|A0ABI0NR78_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA4 PE=3 SV=1 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "1", "start_pos": 106983975, "end_pos": 106925312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141572.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141572.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105002.1" } ] } }, { "isoform_ac": "F1MIZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49/entry#F1MIZ9-1", "sequence": { "sequence": "MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF", "length": 497, "header": "tr|F1MIZ9-1|F1MIZ9_BOVIN Computationally mapped isoform of Importin subunit alpha OS=Bos taurus OX=9913 GN=KPNA3 PE=3 SV=4 CANONICAL=A0AAA9SI49-1" }, "locus": { "chromosome": "1", "start_pos": 106985399, "end_pos": 106925312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006376.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006376.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006376.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006376.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540719", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540719", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O00505-1", "protein_name": "Importin subunit alpha-4", "gene_name": "KPNA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF", "length": 521 }, "evidence": [ { "id": "A0AAA9SI49", "url": "https://omabrowser.org/oma/group/A0AAA9SI49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35344-1", "protein_name": "Importin subunit alpha-4", "gene_name": "Kpna3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTANLQTKEFNF", "length": 521 }, "evidence": [ { "id": "A0AAA9SI49", "url": "https://omabrowser.org/oma/group/A0AAA9SI49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8JFT7-1", "protein_name": "Importin subunit alpha", "gene_name": "kpna3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAENAGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDSDFKGQNVTLDAILQNATSDNAVVQLSAVQAARKLLSSDRNPPIDDLIKCGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVKSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPYLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLTHFSTLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGEEASTIAEIIEECGGLEKIENLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTFNFDSSNLQAKEFKF", "length": 520 }, "evidence": [ { "id": "A0AAA9SI49", "url": "https://omabrowser.org/oma/group/A0AAA9SI49/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" }, { "name": "NLS-dependent protein nuclear import complex", "id": "GO:0042564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042564", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" }, { "name": "NLS-bearing protein import into nucleus", "id": "GO:0006607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" }, { "name": "nuclear localization sequence binding", "id": "GO:0008139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI49" }, { "id": "PS51214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IBB", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 70, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 231, "end_pos": 233 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 82, "end_pos": 84 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH21-1", "uniprot_ac": "A0AAA9SH21", "uniprot_id": "A0AAA9SH21_BOVIN", "mass": { "chemical_mass": 42935.0, "monoisotopic_mass": 42935.0 }, "refseq": {}, "gene_names": [ { "name": "SGCA", "type": "recommended", "evidence": [ { "id": "A0AAA9SH21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ] } ], "protein_names": [ { "name": "Sarcoglycan alpha", "type": "synonym", "evidence": [ { "id": "A0AAA9SH21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.", "evidence": [ { "database": "UniProtKB", "id": "A0A3S5ZPC5", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPC5#function" }, { "database": "UniProtKB", "id": "ARBA00002860", "url": "https://www.uniprot.org/uniprotkb/ARBA00002860#function" }, { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21#function" }, { "database": "UniProtKB", "id": "F1N4P2", "url": "https://www.uniprot.org/uniprotkb/F1N4P2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SGCA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21", "locus": { "chromosome": "19", "start_pos": 36482941, "end_pos": 36506343, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003956", "url": "https://www.ensembl.org/id/ENSBTAG00000003956" } ] } } ], "crossref": [ { "id": "A0AAA9SH21", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003956", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008908", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008908", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VGSEQYF", "url": "https://omabrowser.org/oma/group/VGSEQYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPC5", "url": "https://www.orthodb.org/?gene=A0A3S5ZPC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4P2", "url": "https://www.orthodb.org/?gene=F1N4P2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10132:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10132:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05510", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05510", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9913351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3S5ZPC5", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPC5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4P2", "url": "https://www.uniprot.org/uniprotkb/F1N4P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4P2-1", "url": "https://www.uniprot.org/uniprotkb/F1N4P2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVCYQLPPLSSGLLEGLGGTEAQQTTLHPLVGRVFVHTLDHESFLQRPEHVFSVSAPIPITYHAHLQGHPDLPRWLRYTQRSPYQPGFLYGTATPEDRGHQIIEVTAYNRDSFNTTQQMLVLLIGDPEGPLLPYQAEFLVRSHDVEEVLPSIPASRFLTALGGLWEPAELQLVNITSALDRGGRVPLPIEGRKEGVYIKVGSASPFSTCLKMVVSPDSHARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPADEAPAPGDGILEHDPFFCPPTEATNRDFLTDALVTLLVPLLVALLLTLLLAYVMCCRREGRLKRDLATSDIQMVHHRTIRGNTEELRQMASSREVPRPLSTLPMFNVHTGERLPPQVDSAQVPLILDQH", "length": 387, "header": "tr|A0AAA9SH21-1|A0AAA9SH21_BOVIN Isoform 1 of Sarcoglycan alpha OS=Bos taurus OX=9913 GN=SGCA PE=3 SV=1 CANONICAL=A0AAA9SH21-1" }, "isoforms": [ { "isoform_ac": "A0A3S5ZPC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21/entry#A0A3S5ZPC5-1", "sequence": { "sequence": "MAAALIWISLLVAVSAPIPITYHAHLQGHPDLPRWLRYTQRSPYQPGFLYGTATPEDRGHQIIEVTAYNRDSFNTTQQMLVLLIGDPEGPLLPYQAEFLVRSHDVEEVLPSIPASRFLTALGGLWEPAELQLVNITSALDRGGRVPLPIEGRKEGVYIKVGSASPFSTCLKMVVSPDSHARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPADEAPAPGDGILEHDPFFCPPTEATNRDFLTDALVTLLVPLLVALLLTLLLAYVMCCRREGRLKRDLATSDIQMVHHRTIRGNTEELRQMASSREVPRPLSTLPMFNVHTGERLPPQVDSAQVPLILDQH", "length": 347, "header": "tr|A0A3S5ZPC5-1|A0AAA9SH21_BOVIN Computationally mapped isoform of Sarcoglycan alpha OS=Bos taurus OX=9913 GN=SGCA PE=3 SV=2 CANONICAL=A0AAA9SH21-1" }, "locus": { "chromosome": "19", "start_pos": 36491797, "end_pos": 36483395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005180.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005180.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005180.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005180.5" } ] } }, { "isoform_ac": "A0AAA9SH21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21/entry#A0AAA9SH21-1", "sequence": { "sequence": "MVCYQLPPLSSGLLEGLGGTEAQQTTLHPLVGRVFVHTLDHESFLQRPEHVFSVSAPIPITYHAHLQGHPDLPRWLRYTQRSPYQPGFLYGTATPEDRGHQIIEVTAYNRDSFNTTQQMLVLLIGDPEGPLLPYQAEFLVRSHDVEEVLPSIPASRFLTALGGLWEPAELQLVNITSALDRGGRVPLPIEGRKEGVYIKVGSASPFSTCLKMVVSPDSHARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPADEAPAPGDGILEHDPFFCPPTEATNRDFLTDALVTLLVPLLVALLLTLLLAYVMCCRREGRLKRDLATSDIQMVHHRTIRGNTEELRQMASSREVPRPLSTLPMFNVHTGERLPPQVDSAQVPLILDQH", "length": 387, "header": "tr|A0AAA9SH21-1|A0AAA9SH21_BOVIN Isoform 1 of Sarcoglycan alpha OS=Bos taurus OX=9913 GN=SGCA PE=3 SV=1 CANONICAL=A0AAA9SH21-1" }, "locus": { "chromosome": "19", "start_pos": 36506239, "end_pos": 36483395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133613.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133613.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085502.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085502.1" } ] } }, { "isoform_ac": "F1N4P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21/entry#F1N4P2-1", "sequence": { "sequence": "MGRALLAEAGPSCSGTPARAFPCLLPAPVSVTHRQGQAGAAMAAALIWISLLVGLLEGLGGTEAQQTTLHPLVGRVFVHTLDHESFLQRPEHVFSVSAPIPITYHAHLQGHPDLPRWLRYTQRSPYQPGFLYGTATPEDRGHQIIEVTAYNRDSFNTTQQMLVLLIGDPEGPLLPYQAEFLVRSHDVEEVLPSIPASRFLTALGGLWEPAELQLVNITSALDRGGRVPLPIEGRKEGVYIKVGSASPFSTCLKMVVSPDSHARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPADEAPAPGDGILEHDPFFCPPTEATNRDFLTDALVTLLVPLLVALLLTLLLAYVMCCRREGRLKRDLATSDIQMVHHRTIRGNTEELRQMASSREVPRPLSTLPMFNVHTGERLPPQVDSAQVPLILDQH", "length": 429, "header": "tr|F1N4P2-1|F1N4P2_BOVIN Computationally mapped isoform of Sarcoglycan alpha OS=Bos taurus OX=9913 GN=SGCA PE=3 SV=2 CANONICAL=A0AAA9SH21-1" }, "locus": { "chromosome": "19", "start_pos": 36491920, "end_pos": 36483395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043279.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043279.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040861.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040861.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9913351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913351", "resource": "Reactome", "description": "Formation of the dystrophin-glycoprotein complex (DGC)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7K022-1", "protein_name": "Alpha-sarcoglycan isoform X1", "gene_name": "Sgca", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPGGLLALNTREEAALCLVYGLLAGPRDTKAQQTTLYPLVGRVFVHPLEHASFLRLPEHIAAPPTVRLTYQAHLQGHPDLPRWLRYTQRSPYSPAFLYGTPTPEDRGRQVIEVTAYNRDSFDTTRQRLLLLIEDPEGPRLPYQAEFLVRSHDVEEVLPSTPANRFLTALGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASPDSYARCAQGQPPLLSCYDSLAPHFRVDWCNVSLVDKSVPEPVDEMPTPGDGILEHDPFFCPPTEATGRDFLADALVTLLVPLLVALLLTLLLAYIMCCRREGRLKRDMATSDIQMVHHCTIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQVPLILDQH", "length": 395 }, "evidence": [ { "id": "A0AAA9SH21", "url": "https://omabrowser.org/oma/group/A0AAA9SH21/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LH10-1", "protein_name": "Sarcoglycan, alpha", "gene_name": "Sgca", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWVPIGLLAGLRDSKAQQTTLHPLVGRVFVHPLEHATFLRLPEHIGERGARWAGVCQGSHLVLSLLSSSLLFLPSAVPPTVRLTYHAHLQGHPDLPRWLHYTQRSPYNPGFLYGTPTPEDRGHQVIEVTAYNRDSFDTTRQRLLLLIGDPEGPRLPYQAEFLVRSHDVEEVLPSTPANRFLTALGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASPDSYARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPLDEVPTPGDGILEHDPFFCPPTEATGRDFLTDALVTLLVPVLVALLLTLLLVYIMCCRREGRLKRDMATSDIQMFHHCSIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQMPLILDQH", "length": 410 }, "evidence": [ { "id": "A0AAA9SH21", "url": "https://omabrowser.org/oma/group/A0AAA9SH21/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P82350-1", "protein_name": "Alpha-sarcoglycan", "gene_name": "Sgca", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVTWIPLLAGLLAGLRDTKAQQTTLHLLVGRVFVHPLEHATFLRLPEHVAVPPTVRLTYHAHLQGHPDLPRWLHYTQRSPYNPGFLYGSPTPEDRGYQVIEVTAYNRDSFDTTRQRLLLLIGDPEGPRLPYQAEFLVRSHDVEEVLPTTPANRFLTALGGLWEPGELQLLNITSALDRGGRVPLPIEGRKEGVYIKVGSATPFSTCLKMVASPDSYARCAQGQPPLLSCYDTLAPHFRVDWCNVSLVDKSVPEPLDEVPTPGDGILEHDPFFCPPTEATDRDFLTDALVTLLVPLLVALLLTLLLAYIMCFRREGRLKRDMATSDIQMFHHCSIHGNTEELRQMAASREVPRPLSTLPMFNVRTGERLPPRVDSAQMPLILDQH", "length": 387 }, "evidence": [ { "id": "A0AAA9SH21", "url": "https://omabrowser.org/oma/group/A0AAA9SH21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q16586-1", "protein_name": "Alpha-sarcoglycan", "gene_name": "SGCA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAETLFWTPLLVVLLAGLGDTEAQQTTLHPLVGRVFVHTLDHETFLSLPEHVAVPPAVHITYHAHLQGHPDLPRWLRYTQRSPHHPGFLYGSATPEDRGLQVIEVTAYNRDSFDTTRQRLVLEIGDPEGPLLPYQAEFLVRSHDAEEVLPSTPASRFLSALGGLWEPGELQLLNVTSALDRGGRVPLPIEGRKEGVYIKVGSASPFSTCLKMVASPDSHARCAQGQPPLLSCYDTLAPHFRVDWCNVTLVDKSVPEPADEVPTPGDGILEHDPFFCPPTEAPDRDFLVDALVTLLVPLLVALLLTLLLAYVMCCRREGRLKRDLATSDIQMVHHCTIHGNTEELRQMAASREVPRPLSTLPMFNVHTGERLPPRVDSAQVPLILDQH", "length": 387 }, "evidence": [ { "id": "A0AAA9SH21", "url": "https://omabrowser.org/oma/group/A0AAA9SH21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "pmid": "" }, { "name": "sarcoglycan complex", "id": "GO:0016012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH21" }, { "id": "SM00736", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00736" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dystroglycan-type cadherin-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 131, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 246, "end_pos": 248 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFN1-1", "uniprot_ac": "A0AAA9SFN1", "uniprot_id": "A0AAA9SFN1_BOVIN", "mass": { "chemical_mass": 46174.0, "monoisotopic_mass": 46174.0 }, "refseq": {}, "gene_names": [ { "name": "SEC14L2", "type": "recommended", "evidence": [ { "id": "A0AAA9SFN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" } ] } ], "protein_names": [ { "name": "SEC14 like lipid binding 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SFN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC14L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1", "locus": { "chromosome": "17", "start_pos": 69420051, "end_pos": 69398586, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017404", "url": "https://www.ensembl.org/id/ENSBTAG00000017404" } ] } } ], "crossref": [ { "id": "A0AAA9SFN1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017404", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017404", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282469", "url": "https://www.ncbi.nlm.nih.gov/gene/282469", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282469", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282469", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HCYDKVG", "url": "https://omabrowser.org/oma/group/HCYDKVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T8D1", "url": "https://www.orthodb.org/?gene=A0A140T8D1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23324", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23324", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23324:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23324:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00650", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00650", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_808812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808812", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A140T8D1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T8D1-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8D1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S856", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S856", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S856-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S856-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRVGDLSPKQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARNFNLQKSEAMLRKHVEFRKQKDIDNIMSWQPPEVVQQYLSGGMCGYDLEGSPIWYDIIGPLDAKGLLLSASKQDLFKTKMRDCELLLQECVRQTEKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKASEEKMQQLGAVTPK", "length": 403, "header": "tr|A0AAA9SFN1-1|A0AAA9SFN1_BOVIN Isoform 1 of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=1 CANONICAL=A0AAA9SFN1-1" }, "isoforms": [ { "isoform_ac": "A0A140T8D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#A0A140T8D1-1", "sequence": { "sequence": "MSGRVGDLSPKQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARNFNLQKSEAMLRKHVEFRKQKDIDNIMSWQPPEVVQQYLSGGMCGYDLEGSPIWYDIIGPLDAKGLLLSASKQDLFKTKMRDCELLLQECVRQTEKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGIWQDPEEIVPERGEALRPVSMATPPVLN", "length": 387, "header": "tr|A0A140T8D1-1|A0AAA9SFN1_BOVIN Computationally mapped isoform of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=2 CANONICAL=A0AAA9SFN1-1" }, "locus": { "chromosome": "17", "start_pos": 69415603, "end_pos": 69398667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056675.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056675.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051657.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051657.3" } ] } }, { "isoform_ac": "A0AAA9RSZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#A0AAA9RSZ5-1", "sequence": { "sequence": "GSRRLGDSTARGGFRENVQDVLPALPNPDDYFLLRWLRARNFNLQKSEAMLRKHVEFRKQKDIDNIMSWQPPEVVQQYLSGGMCGYDLEGSPIWYDIIGPLDAKGLLLSASKQDLFKTKMRDCELLLQECVRQTEKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKASEEKMQQLGAVTPK", "length": 398, "header": "tr|A0AAA9RSZ5-1|A0AAA9SFN1_BOVIN Computationally mapped isoform of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=1 CANONICAL=A0AAA9SFN1-1" }, "locus": { "chromosome": "17", "start_pos": 69419872, "end_pos": 69400028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099264.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099264.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075874.1" } ] } }, { "isoform_ac": "A0AAA9S856-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#A0AAA9S856-1", "sequence": { "sequence": "MLRKVVQQYLSGGMCGYDLEGSPIWYDIIGPLDAKGLLLSASKQDLFKTKMRDCELLLQECVRQTEKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKASEEKMQQLGAVTPK", "length": 329, "header": "tr|A0AAA9S856-1|A0AAA9SFN1_BOVIN Computationally mapped isoform of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=1 CANONICAL=A0AAA9SFN1-1" }, "locus": { "chromosome": "17", "start_pos": 69419872, "end_pos": 69405774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121071.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121071.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081421.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081421.1" } ] } }, { "isoform_ac": "A0AAA9SFN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#A0AAA9SFN1-1", "sequence": { "sequence": "MSGRVGDLSPKQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARNFNLQKSEAMLRKHVEFRKQKDIDNIMSWQPPEVVQQYLSGGMCGYDLEGSPIWYDIIGPLDAKGLLLSASKQDLFKTKMRDCELLLQECVRQTEKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKASEEKMQQLGAVTPK", "length": 403, "header": "tr|A0AAA9SFN1-1|A0AAA9SFN1_BOVIN Isoform 1 of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=1 CANONICAL=A0AAA9SFN1-1" }, "locus": { "chromosome": "17", "start_pos": 69419872, "end_pos": 69398667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132687.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132687.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081269.1" } ] } }, { "isoform_ac": "A0AAA9THC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#A0AAA9THC2-1", "sequence": { "sequence": "MSGRVGDLSPKQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARNFNLQKSEAMLRKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKASEEKMQQLGAVTPK", "length": 320, "header": "tr|A0AAA9THC2-1|A0AAA9THC2_BOVIN Computationally mapped isoform of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=1 CANONICAL=A0AAA9SFN1-1" }, "locus": { "chromosome": "17", "start_pos": 69419872, "end_pos": 69398667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107196.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107196.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096470.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096470.1" } ] } }, { "isoform_ac": "A0AAA9TYX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1/entry#A0AAA9TYX9-1", "sequence": { "sequence": "MSGRVGDLSPKQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARNFNLQKSEAMLRKHVEFRKQKDIDNIMSWQPPEVVQQYLSGGMCGYDLEGSPIWYDIIGPLDAKGLLLSASKQDLFKTKMRDCELLLQECVRQTEKMGKKIEATTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFIVKAPKLFPVAYNLVKPFLSEDTRKKIQVLGANWKEVLLKYISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKVGERQRAGEMREVLPSQRYNAHLVPEDGSLTCSDPGICLPGL", "length": 365, "header": "tr|A0AAA9TYX9-1|A0AAA9TYX9_BOVIN Computationally mapped isoform of SEC14 like lipid binding 2 OS=Bos taurus OX=9913 GN=SEC14L2 PE=4 SV=1 CANONICAL=A0AAA9SFN1-1" }, "locus": { "chromosome": "17", "start_pos": 69414344, "end_pos": 69398667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112220.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112220.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103847.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103847.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282469", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282469", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZRQ5-1", "protein_name": "SEC14 like lipid binding 2", "gene_name": "SEC14L2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRVGDLSPKQKEALAKFRENVQDVLPTLPNPDDHFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNILNWQPPEVIQQYLSGGLCGYDLDGCPVWYDVIGPLDAKGLLLSATKQDLLRTKMRDCELIQRECACQTEKTGKKIETVTLIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKINVLGANWKEVLLKYISPDQVPVEYGGTMTDPDGDPKCKSKINYGGDIPKKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGSDIGFGIFLKTKMGERQRAGEMTEVLASQRYNAHLVPEDGTLTCSNPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKASEEKMKQLGEATPK", "length": 403 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7EZC8-1", "protein_name": "Coiled-coil domain-containing protein 157 isoform X1", "gene_name": "Ccdc157", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGRWRRPREKPRKLVNTLPVTPPGRGALPTPPRGQGGALLRCHGSSLGAPLRVSRDHRSHWRSGGSSVSRPDTELRLRRRRQGWEGRLRPALYLNQESKSQKARHLHEPQISVLSPIGGHSRSLHLHGQTSVRAPGVVGMAHLLGSQACMDSLRKDLTDLQGTIVDVFSRAGPVRFPSWKFPDRVACDLDMVALLEHYDHVPGDPEFTQLSHAVLLELVIDRLLLLLQSCASYLENLSLEQMMPPTRAPGPCMSVGLTVRRFWSNLLRLGMLYQQAAPQKRANQGEIPIAKPTAKGEPSRSPECMTAKFIKPPSPVPGLPLICPGLQSIPVRVSIRGPPGTSEKTKSVYSQTIETALVPCDACTSVQGSLWEVGKVVISLCQSQNLPSSLGQFQKLVQDSMGLKPLPAATMSHWAAEQSKDLTRLNKHVGALTQLVGPLRAQLEDAEGQKDELRKQVDKLEQALRQEKGERQRQAEEAERSLAKCEHDRQQLLTETCDLKTKVATLEGDLKQQQKSMQATVAKAQQLEEEGERRAAAERQVQQLEEQVQLLAGRLDGAGQQIRWASTELDKEKARVDSMVRHQESLQAKQRTLLQQLDSLDQEREELRGSLDEAEARRAELEEQLQSLQNDREQGQCQIQAQQELLHSLHQEKQDLEQVTTDLQLTISELHLELEDLKERERLLVTFPDLHQHMEAQIQSSGNVTHDMEKQVQANDIRIQVLQEDNRRLQSMLTKIREVAQQGGLKMIPQGQLWSLPYKDTQGEVPPAQAQNTSPGPMGRRQSPVSRTSSTGRTPSGGPRASPPRQPWPSKSSLEDRTYSATCTQNPMRALARLRRKLSPNRGQAGSPYQPQERPT", "length": 856 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2BIR0-1", "protein_name": "SEC14-like lipid binding 8", "gene_name": "sec14l8", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGRVGDLSVKQAEALAQFREKVQDVLPQCPSQSDHFLLRWLRARNFNLQKSEAMLRKHIEFRKHMKVDTITTEWQVPEVIDKYLSGGMCGHDREGSPVWYDVIGPLDPKGLMHSASKQDLIKSKVRDCEILQKDCDRQSERLGRNIESITMVYDCEGLGMKHLYKPAIETYGEVLTMFEDNYPEGLKRLFVIKAPKLFPVAYNLVKHFLSEDTRRKVIVLGSNWQEVLQKYIDPEELPAYYGGKLTDPDGDPKCRTRITFGSEIPKSYYVRDSIKVDYEQSVSIGRGSSHQMEYELIAPNCALRWQFSCDGADIGFGVYLKKKMGERMKAGEMREIVPNQRYNAHLVPEDGSLTCPEPGVYVLRFDNTYSVFQSKTVKFTVEVLLPSQVNQSDN", "length": 395 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O76054-1", "protein_name": "SEC14-like protein 2", "gene_name": "SEC14L2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK", "length": 403 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q55CK3-1", "protein_name": "Cellular retinaldehyde-binding/triple function domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSGFIKDLSQPQSEALNQFKEYLNKKETIVQIKSDIKNKLPTTTTTTTTTNTETEESSSSSSPSSKEEEKHLKIWNINLENDSKERDIILLKFLRAREFKIENSKQMLIDCLIWRKQNQVDDYEKIVNEAFPDYYKNIGTIFKTDKEGRPVMINHYHAINPDVIFKDGVDQFVRWKVQQMEIAIRDTLIPSQWEIEDLIVIHDYKDCSFFRMDPRIKQASNQTIQTLQNNYPEFLARKFFINIPWLMEKLFSIFTVFTSERTKSKFIICSGNYREKLLKYIEADSIAPKLSGFEDNQSPILNIKIKPQKSHSIQLGKLDADKTIEWEFCTNEIDSEIGAKILIEPNNQPTTSNDILYFNNNSNNNNNNNNSPTPSNSNYPFNCFLSIEPREFNSGSIQIEDDSYYTLVFNNHLNKQCDLFYRITIKSKTTHSSTTTSTIETLGN", "length": 444 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q99J08-1", "protein_name": "SEC14-like protein 2", "gene_name": "Sec14l2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRVGDLSPKQEEALAKFRENVQDVLPTLPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDKIISWQPPEVIQQYLSGGRCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRDCELLLQECIQQTTKLGKKIETITMIYDCEGLGLKHLWKPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRRKIMVLGANWKEVLLKHISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKQYYVRDQVKQQYEHTVQVSRGSSHQVEYEILFPGCVLRWQFMSEGSDVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHMVPEDGTLTCSEPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKAAEEKMNQQGADTPK", "length": 403 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99MS0-1", "protein_name": "SEC14-like protein 2", "gene_name": "Sec14l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRVGDLSPKQEEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDKIISWQPPEVIQQYLSGGRCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRDCELLLQECTQQTAKLGKKIETITMIYDCEGLGLKHLWKPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQLPVEYGGTMTDPDGNPKCKSKINYGGDIPKQYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSEGSDVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHMVPEDGTLTCSEPGIYVLRFDNTYSFIHAKKVSFTVEVLLPDKAAEEKLNQQGAVTPK", "length": 403 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9SCU1-1", "protein_name": "Patellin-6", "gene_name": "PATL6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDASLSPFDHQKTQNTEPKKSFITSLITLRSNNIKEDTYFVSELKPTEQKSLQELKEKLSASSSKASSMWGVSLLGGDDKADVILLKFLRARDFKVADSLRMLEKCLEWREEFKAEKLTEEDLGFKDLEGKVAYMRGYDKEGHPVCYNAYGVFKEKEMYERVFGDEEKLNKFLRWRVQVLERGVKMLHFKPGGVNSIIQVTDLKDMPKRELRVASNQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKEGNAAETLYKFIRPEDIPVQYGGLSRPTDSQNGPPKPASEFSIKGGEKVNIQIEGIEGGATITWDIVVGGWDLEYSAEFVPNAEESYAIVVEKPKKMKATDEAVCNSFTTVEAGKLILSVDNTLSRKKKVAAYRYTVRKSTTTV", "length": 409 }, "evidence": [ { "id": "A0AAA9SFN1", "url": "https://omabrowser.org/oma/group/A0AAA9SFN1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" }, { "id": "PS50191", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50191" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRAL-TRIO", "eco_id": "ECO_0000259", "start_pos": 76, "end_pos": 249, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN1" }, { "id": "PS50866", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GOLD", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 383, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH94-1", "uniprot_ac": "A0AAA9SH94", "uniprot_id": "A0AAA9SH94_BOVIN", "mass": { "chemical_mass": 35622.0, "monoisotopic_mass": 35622.0 }, "refseq": { "ac": "NP_001415191", "name": "NADH-cytochrome b5 reductase-like isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001415191" }, "gene_names": [ { "name": "CYB5RL", "type": "recommended", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ] }, { "name": "CYB5RL", "type": "synonym", "evidence": [ { "id": "NP_001415191", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001415191" } ] } ], "protein_names": [ { "name": "NADH-cytochrome b5 reductase", "type": "recommended", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94/entry#names_and_taxonomy" } ] }, { "name": "1.6.2.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94/entry#names_and_taxonomy" } ] }, { "name": "NADH-cytochrome b5 reductase-like isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001415191", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001415191" } ] } ], "function": [ { "annotation": "NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LIS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIS5#function" }, { "database": "UniProtKB", "id": "ARBA00055239", "url": "https://www.uniprot.org/uniprotkb/ARBA00055239#function" }, { "database": "UniProtKB", "id": "A0A3Q1MDH3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDH3#function" }, { "database": "UniProtKB", "id": "A0AAA9SH94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYB5RL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94", "locus": { "chromosome": "3", "start_pos": 92059183, "end_pos": 92033309, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020037", "url": "https://www.ensembl.org/id/ENSBTAG00000020037" } ] } } ], "crossref": [ { "id": "A0AAA9SH94", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020037", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020037", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06183", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06183", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526748", "url": "https://www.ncbi.nlm.nih.gov/gene/526748", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YSPYWTD", "url": "https://omabrowser.org/oma/group/YSPYWTD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LIS5", "url": "https://www.orthodb.org/?gene=A0A3Q1LIS5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDH3", "url": "https://www.orthodb.org/?gene=A0A3Q1MDH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19370", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19370", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19370:SF184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19370:SF184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00970", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00970", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1237044", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237044", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001415191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001415191", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "46680", "url": "https://www.rhea-db.org/rhea/46680", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LIS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDH3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDH3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDQGEEGDEEEAWLQLRPVEPLPSQCCGSGCSPCVFDIYQRDLARWEAARASKDRSLLSREETQSCPSKLSPETFLAFLISAVDRLTEDTYLVRFALPGNSQLGLRPGQHLILRGTVDDLEIQRAYTPISPANAEGYFEVLIKCYQTGLMSRYVKSWKAGDTAFWRGPFGGFFYKPNQYGELLMLAAGTGLAPMVPILQSITDNAEDETFITLVGCFKTFEGIYLKTFLQEQARFWNVRTFFVLSQENSLEQLPWSYRDRTRFGRLDRDLLEELVGSCRRKPFALVCGSAEFTKDMAGYLLHAGLAEDSYFLF", "length": 314, "header": "tr|A0AAA9SH94-1|A0AAA9SH94_BOVIN Isoform 1 of NADH-cytochrome b5 reductase OS=Bos taurus OX=9913 GN=CYB5RL PE=3 SV=1 CANONICAL=A0AAA9SH94-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94/entry#A0A3Q1LIS5-1", "sequence": { "sequence": "MMDQGEEGDEEEAWLQLRPVEPLPSQCCGSGCSPCVFDIYQRDLARWEAARASKDRSLLSREETQSCPSKLSPETFLAFLISAVDRLTEDTYLVRFALPGNSQLGLRPGQHLILRGTVDDLEIQRAYTPISPANAEGYFEVLIKCYQTGLMSRYVKSWKAGDTAFWRGPFGGFFYKPNQENSLEQLPWSYRDRTRFGRLDRDLLEELVGSCRRKPFALVCGSAEFTKDMAGYLLHAGLAEDSYFLF", "length": 246, "header": "tr|A0A3Q1LIS5-1|A0AAA9SH94_BOVIN Computationally mapped isoform of NADH-cytochrome b5 reductase OS=Bos taurus OX=9913 GN=CYB5RL PE=3 SV=2 CANONICAL=A0AAA9SH94-1" }, "locus": { "chromosome": "3", "start_pos": 92058161, "end_pos": 92039291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068812.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068812.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059054.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059054.2" } ] } }, { "isoform_ac": "A0A3Q1MDH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94/entry#A0A3Q1MDH3-1", "sequence": { "sequence": "MMDQGEEGDEEEAWLQLRPVEPLPSQCCGSGCSPCVFDIYQRDLARWEAARASKDRSLLSREETQSCPSKLSPETFLAFLISAVDRLTEDTYLVRFALPGNSQLGLRPGQHLILRGTVDDLEIQRAYTPISPANAEGYFEVLIKCYQTGLMSRYVKSWKAGDTAFWRGPFGGFFYKPNQYGELLMLAAGTGLAPMVPILQSITDNAEDETFITLVGCFKTFEGIYLKTFLQEQARFWNVRTFFVLSQENSLEQLPWSYRDRTRFGRLDRDLLEELVGSCRRKPFALAWPRF", "length": 291, "header": "tr|A0A3Q1MDH3-1|A0A3Q1MDH3_BOVIN Computationally mapped isoform of NADH-cytochrome b5 reductase-like OS=Bos taurus OX=9913 GN=CYB5RL PE=3 SV=1 CANONICAL=A0AAA9SH94-1" }, "locus": { "chromosome": "3", "start_pos": 92058179, "end_pos": 92039291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077545.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077545.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068977.1" } ] } }, { "isoform_ac": "A0AAA9SH94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94/entry#A0AAA9SH94-1", "sequence": { "sequence": "MMDQGEEGDEEEAWLQLRPVEPLPSQCCGSGCSPCVFDIYQRDLARWEAARASKDRSLLSREETQSCPSKLSPETFLAFLISAVDRLTEDTYLVRFALPGNSQLGLRPGQHLILRGTVDDLEIQRAYTPISPANAEGYFEVLIKCYQTGLMSRYVKSWKAGDTAFWRGPFGGFFYKPNQYGELLMLAAGTGLAPMVPILQSITDNAEDETFITLVGCFKTFEGIYLKTFLQEQARFWNVRTFFVLSQENSLEQLPWSYRDRTRFGRLDRDLLEELVGSCRRKPFALVCGSAEFTKDMAGYLLHAGLAEDSYFLF", "length": 314, "header": "tr|A0AAA9SH94-1|A0AAA9SH94_BOVIN Isoform 1 of NADH-cytochrome b5 reductase OS=Bos taurus OX=9913 GN=CYB5RL PE=3 SV=1 CANONICAL=A0AAA9SH94-1" }, "locus": { "chromosome": "3", "start_pos": 92058161, "end_pos": 92039291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127275.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127275.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081870.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081870.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1237044", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237044", "resource": "Reactome", "description": "Erythrocytes take up carbon dioxide and release oxygen" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FMV2-1", "protein_name": "NADH-cytochrome b5 reductase", "gene_name": "CYB5RL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMAEREEDEEEAWLQLRPVEPLPSQCCGSGCSPCVFDLYQRDLARWEAARASKDRSLLRGSTSQSCPSELNPETFMAFRISAVDRLSKDTYLVRFALPGNSQLGLRPGQHLILRGTVDDLEIQRAYTPISPANTEGYFEVLIKCYQTGLMSQCVKSWRVGDAAFWRGPFGSFCYKPNQYGELLMLAAGTGLAPMVPILQSITDNAEDETFVTLVGCFKTFEGIYLKAFLQEQARFWNVRTFFVLSQENSPEQLPWSYRDKTRFGRLGQDLVDELVGSCRRKPFALVCGSAEFTQDVARCLLSAGLAEDAYFLF", "length": 313 }, "evidence": [ { "id": "A0AAA9SH94", "url": "https://omabrowser.org/oma/group/A0AAA9SH94/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B1AS42-1", "protein_name": "NADH-cytochrome b5 reductase-like", "gene_name": "Cyb5rl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETEEEEDSEAWLRLKPVEPLPSQCCGSGCSPCVFDLYYRDLERWETARARNDRSLLSGKQPPESQSCSAKLSPETFLAFHISTMEKVTKDTYLVRFTLPGNSRLGLRPGQHLILRGVVDGLEIQRAYTPISPVTAEGYFDVLIKCYRTGLMSQYVESWRTGDTAFWRGPFGSFLYEPKKYGELLMLAAGTGLAPMVPILQSITDDEDDETFVTLVGCFKTFEGIYLKTFFQEQARFWNVQTFFVLSQEVSPEQLPWSYRDKTHFGRLGQELVAELVACCRRKPFTLVCGSPAFNEDMARCLLSAGLTEDSYFLF", "length": 316 }, "evidence": [ { "id": "A0AAA9SH94", "url": "https://omabrowser.org/oma/group/A0AAA9SH94/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1NPT9-1", "protein_name": "NADH-cytochrome b5 reductase", "gene_name": "LOC112529965", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGSEEEWRALKPREPSPSQCCGGGCQPCVYDVYEQQLARWERARAARDKGLLVEGRGESGNSELSPDAFTAFSLSWVRQLTEDTYQCRFELPGNGSLRLGLGQHLVLRGVVNGLEVQRAYTPISPGNAEGYFEVLIKCYEAGLMSQYIKTWKEGDTAFWRGPFGGFPYRPNKHGELLMLASGTGLAPMLPILQSITDDEEDETFVTLVGCFCTFEKIYLKPLLQDLARYWNIRIFYVLSQETSKENLPWSYQENTYIGRLNEDLIRTVINSCRRKPFVLICGSSAFTEDMNRYLKAAGIEEDSCFVF", "length": 308 }, "evidence": [ { "id": "A0AAA9SH94", "url": "https://omabrowser.org/oma/group/A0AAA9SH94/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GTL8-1", "protein_name": "NADH-cytochrome b5 reductase-like", "gene_name": "LOC100753272", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDQRVDNDAEAWLQLKPVEPLPSQCCGSGCSPCVFDLYSRDLERWEAARARNDRSLLSGKQSPETQGCSTKLSPETFLAFHISAIEKLTKDTLRVRFTLPGNNQLGLHPGQHLILRGIADGLEIQRAYTPISPVTAEGYFDVLIKCYQAGLMSQYVESWRTGDTAFWRGPFGSFLYEPNKYGELLMLAAGTGLAPMVPILHSITDNADDETFVTLVCCFKTFESIYLKTFLQEQARFWNVRTFFVLSQEVSPEQLPWSYREKTHFGRLGQELVDELVACCRRKPFTLVCGSSSFTKDMARCLLSAGLTEDSYFLF", "length": 315 }, "evidence": [ { "id": "A0AAA9SH94", "url": "https://omabrowser.org/oma/group/A0AAA9SH94/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6IPT4-1", "protein_name": "NADH-cytochrome b5 reductase-like", "gene_name": "CYB5RL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMAEREEDDDTEEAWMQLRPTEPLPSQCCGSGCSPCVFDLYHRDLARWEAAQASKDRSLLRGPESQSCPSKLNPETFVAFCIIAMDRLTKDTYRVRFALPGNSQLGLRPGQHLILRGIVDDLEIQRAYTPISPANAEGYFEVLIKCYQMGLMSRYVESWRVGDTAFWRGPFGDFFYKPNQYGELLLLAAGTGLAPMVPILQSITDNENDETFVTLVGCFKTFESIYLKTFLQEQARFWNVRTFFVLSQESSSEQLPWSYQEKTHFGHLGQDLIKELVSCCRRKPFALVCGSAEFTKDIARCLLCAGLTEDSYFLF", "length": 315 }, "evidence": [ { "id": "A0AAA9SH94", "url": "https://omabrowser.org/oma/group/A0AAA9SH94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VWK8-1", "protein_name": "FAD-binding FR-type domain-containing protein", "gene_name": "Dmel\\CG7914", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLSYLEDLKENEDQLRDSDCCGNGCTNCILDNKPRPSKRVLLAGKRNVILSYTKFRLLRREALGPNGQLLLLHFAHAAEEGDGDGAVDTVLDIPPGHHVMLRVGSLLRPYSPYWSDFVAKEFRILVKLQPEGPMSRHLQAVQPDDLLEFRGPIGQYVHEPQPAKCIYIIAQGVAIAPTLPLVRQVLDNEEDMSRLWHLVCAHDLLHVYFREEMLEFAQFWNYRSCLYLPHQQCDSSACQEAGHCAQQCPQLRDNLRYKETAKVSRLDATELATHLNPAIPGQRVLIVAGDSSFQKNIAQIATQSLDVDPANIYML", "length": 315 }, "evidence": [ { "id": "A0AAA9SH94", "url": "https://omabrowser.org/oma/group/A0AAA9SH94/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ], "pmid": "" }, { "name": "cytochrome-b5 reductase activity, acting on NADH", "id": "GO:0090524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "46680", "name": "", "equation": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LH7-1", "Q3MHW9-1", "A0AAA9SH94-1", "P07514-1", "A0A3Q1MXD6-1" ], "evidence": [ { "id": "46680", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46680" } ] }, { "id": "R-BTA-6806831", "name": "CYB5Rs reduce MetHb to HbA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SH94-1", "Q32LH7-1", "Q3MHW9-1" ], "evidence": [ { "id": "R-BTA-6806831", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6806831" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MXD6", "gene_name": "CYB5R2", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "A0A3Q1MXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD6" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1MXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD6" } ] } ] }, { "uniprot_ac": "A0AAA9SH94", "gene_name": "CYB5RL", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ] } ] }, { "uniprot_ac": "P07514", "gene_name": "CYB5R3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] } ] }, { "uniprot_ac": "Q32LH7", "gene_name": "CYB5R4", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "Q32LH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH7" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q32LH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH7" } ] } ] }, { "uniprot_ac": "Q3MHW9", "gene_name": "CYB5R1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" }, { "id": "PS51384", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51384" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD-binding FR-type", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 176, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.6.2.2", "ec_name": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "1.6.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2" }, { "id": "1.6.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.6.2.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEH3-1", "uniprot_ac": "A0AAA9SEH3", "uniprot_id": "A0AAA9SEH3_BOVIN", "mass": { "chemical_mass": 48778.0, "monoisotopic_mass": 48778.0 }, "refseq": {}, "gene_names": [ { "name": "SLC17A9", "type": "recommended", "evidence": [ { "id": "A0AAA9SEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ] } ], "protein_names": [ { "name": "Voltage-gated purine nucleotide uniporter SLC17A9", "type": "recommended", "evidence": [ { "id": "A0AAA9SEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 17 member 9", "type": "synonym", "evidence": [ { "id": "A0AAA9SEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3/entry#names_and_taxonomy" } ] }, { "name": "Vesicular nucleotide transporter", "type": "synonym", "evidence": [ { "id": "A0AAA9SEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles. By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles. Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles.", "evidence": [ { "database": "UniProtKB", "id": "F6Q7Q6", "url": "https://www.uniprot.org/uniprotkb/F6Q7Q6#function" }, { "database": "UniProtKB", "id": "ARBA00056522", "url": "https://www.uniprot.org/uniprotkb/ARBA00056522#function" }, { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC17A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3", "locus": { "chromosome": "13", "start_pos": 54445535, "end_pos": 54459936, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001829", "url": "https://www.ensembl.org/id/ENSBTAG00000001829" } ] } } ], "crossref": [ { "id": "A0AAA9SEH3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001829", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001829", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPQ3", "url": "https://www.orthodb.org/?gene=A0A3Q1LPQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6Q7Q6", "url": "https://www.orthodb.org/?gene=F6Q7Q6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11662:SF279", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11662:SF279", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "75687", "url": "https://www.rhea-db.org/rhea/75687", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "75783", "url": "https://www.rhea-db.org/rhea/75783", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "75787", "url": "https://www.rhea-db.org/rhea/75787", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LPQ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q7Q6", "url": "https://www.uniprot.org/uniprotkb/F6Q7Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q7Q6-1", "url": "https://www.uniprot.org/uniprotkb/F6Q7Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPPPDETRRDAAEDTQWSRPECQVWTGTLLLGTCLLYCARVSMPVCAASMSQDFGWNKKEAGVVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVATPLLAHLGSAHLAFMTFSRILTGLLQGVYFPALTSLLSQKVRESERAFTYSTVGAGSQFGTLVTGAVGSLLLDWYGWPSVFYFSGGLTLLWVGYVYRCLLSERGPSSHLDGFHVDLPPPSDLILALGILAQGLPVSRHTKVPWRQLFRKPSVWAAIISQLSAACSFFILLSWLPTFFKETFPSSKGWVFNVVPWLVAIPASLLSGLLSDHLINQGYRTITVRKFMQVMGLGLSSVFALCLGHTSSFCNSVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLIETTGSWTSVFNLVATISSLGLCTFLVFGKAQRVDLSPAHEDL", "length": 453, "header": "tr|A0AAA9SEH3-1|A0AAA9SEH3_BOVIN Isoform 1 of Voltage-gated purine nucleotide uniporter SLC17A9 OS=Bos taurus OX=9913 GN=SLC17A9 PE=3 SV=1 CANONICAL=A0AAA9SEH3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3/entry#A0A3Q1LPQ3-1", "sequence": { "sequence": "MQPPPDETRRDAAEDTQWSRPECQVWTGTLLLGTCLLYCARVSMPVCAASMSQDFGWNKKEAGVVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVATPLLAHLGSAHLAFMTFSRILTGLLQGVYFPALTSLLSQKVRESERAFTYSTVGAGSQFGTLVTGAVGSLLLDWYGWPSVFYFSGGLTLLWVGYVYRCLLSERDLILALGILAQGLPVSRHTKVPWRQLFRKPSVWAAIISQLSAACSFFILLSWLPTFFKETFPSSKVMGLGLSSVFALCLGHTSSFCNSVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLIETTGSWTSVFNLVATISSLGLCTFLVFGKAQRVDLSPAHEDL", "length": 395, "header": "tr|A0A3Q1LPQ3-1|A0AAA9SEH3_BOVIN Computationally mapped isoform of Voltage-gated purine nucleotide uniporter SLC17A9 OS=Bos taurus OX=9913 GN=SLC17A9 PE=3 SV=3 CANONICAL=A0AAA9SEH3-1" }, "locus": { "chromosome": "13", "start_pos": 54459899, "end_pos": 54446372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077296.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077296.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058921.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058921.3" } ] } }, { "isoform_ac": "A0AAA9SEH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3/entry#A0AAA9SEH3-1", "sequence": { "sequence": "MQPPPDETRRDAAEDTQWSRPECQVWTGTLLLGTCLLYCARVSMPVCAASMSQDFGWNKKEAGVVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVATPLLAHLGSAHLAFMTFSRILTGLLQGVYFPALTSLLSQKVRESERAFTYSTVGAGSQFGTLVTGAVGSLLLDWYGWPSVFYFSGGLTLLWVGYVYRCLLSERGPSSHLDGFHVDLPPPSDLILALGILAQGLPVSRHTKVPWRQLFRKPSVWAAIISQLSAACSFFILLSWLPTFFKETFPSSKGWVFNVVPWLVAIPASLLSGLLSDHLINQGYRTITVRKFMQVMGLGLSSVFALCLGHTSSFCNSVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLIETTGSWTSVFNLVATISSLGLCTFLVFGKAQRVDLSPAHEDL", "length": 453, "header": "tr|A0AAA9SEH3-1|A0AAA9SEH3_BOVIN Isoform 1 of Voltage-gated purine nucleotide uniporter SLC17A9 OS=Bos taurus OX=9913 GN=SLC17A9 PE=3 SV=1 CANONICAL=A0AAA9SEH3-1" }, "locus": { "chromosome": "13", "start_pos": 54459899, "end_pos": 54446372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083795.1" } ] } }, { "isoform_ac": "F6Q7Q6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3/entry#F6Q7Q6-1", "sequence": { "sequence": "MQPPPDETRRDAAEDTQWSRPECQVWTGTLLLGTCLLYCARVSMPVCAASMSQDFGWNKKEAGVVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVATPLLAHLGSAHLAFMTFSRILTGLLQGVYFPALTSLLSQKVRESERAFTYSTVGAGSQFGTLVTGAVGSLLLDWYGWPSVFYFSGGLTLLWVGYVYRCLLSERDLILALGILAQGLPVSRHTKVPWRQLFRKPSVWAAIISQLSAACSFFILLSWLPTFFKETFPSSKGWVFNVVPWLVAIPASLLSGLLSDHLINQGYRTITVRKFMQVMGLGLSSVFALCLGHTSSFCNSVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVVGVCLGGYLIETTGSWTSVFNLVATISSLGLCTFLVFGKAQRVDLSPAHEDL", "length": 426, "header": "tr|F6Q7Q6-1|F6Q7Q6_BOVIN Computationally mapped isoform of Voltage-gated purine nucleotide uniporter SLC17A9 OS=Bos taurus OX=9913 GN=SLC17A9 PE=3 SV=2 CANONICAL=A0AAA9SEH3-1" }, "locus": { "chromosome": "13", "start_pos": 54459899, "end_pos": 54446372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044985.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044985.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042417.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042417.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "chromaffin granule membrane", "id": "GO:0042584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042584", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "mucin granule", "id": "GO:0098594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "secondary active transmembrane transporter activity", "id": "GO:0015291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015291", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "ATP transmembrane transporter activity", "id": "GO:0005347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005347", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "ADP transmembrane transporter activity", "id": "GO:0015217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015217", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "guanine nucleotide transmembrane transporter activity", "id": "GO:0001409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "purine nucleotide uniporter activity", "id": "GO:0160042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ATP export", "id": "GO:1904669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "purine nucleotide import into lysosome", "id": "GO:0141013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "ATP transport", "id": "GO:0015867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015867", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" }, { "name": "purine-containing compound transmembrane transport", "id": "GO:0072530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072530", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "75687", "name": "", "equation": "ATP(in) = ATP(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "75687", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75687" } ] }, { "id": "75783", "name": "", "equation": "ADP(in) = ADP(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "75783", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75783" } ] }, { "id": "75787", "name": "", "equation": "GTP(in) = GTP(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "75787", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75787" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEH3" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 443, "start_aa": "Trp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 369, "end_pos": 371 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGV5-1", "uniprot_ac": "A0AAA9SGV5", "uniprot_id": "A0AAA9SGV5_BOVIN", "mass": { "chemical_mass": 33243.0, "monoisotopic_mass": 33243.0 }, "refseq": {}, "gene_names": [ { "name": "TPD52", "type": "recommended", "evidence": [ { "id": "A0AAA9SGV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5" } ] } ], "protein_names": [ { "name": "Tumor protein D52", "type": "synonym", "evidence": [ { "id": "A0AAA9SGV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPD52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5", "locus": { "chromosome": "14", "start_pos": 43230437, "end_pos": 43360255, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007335", "url": "https://www.ensembl.org/id/ENSBTAG00000007335" } ] } } ], "crossref": [ { "id": "A0AAA9SGV5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007335", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007335", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540235", "url": "https://www.ncbi.nlm.nih.gov/gene/540235", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MDRREMD", "url": "https://omabrowser.org/oma/group/MDRREMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BE76", "url": "https://www.orthodb.org/?gene=E1BE76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19307", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19307", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19307:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19307:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RU45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9P1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE76", "url": "https://www.uniprot.org/uniprotkb/E1BE76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE76-1", "url": "https://www.uniprot.org/uniprotkb/E1BE76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MINNLRVRRNAIPVSTRSPRSLHGAAASWPSPPSPLLQGGLQPALTRPSPPRRPAPPAGPPPAPTRRSAPARGVRWLGDAPGKRSPPRAGGATAPDASGGGDFPGAAGGGREERCAAGGRAGRAGTGCRREGDMDRSEQGLLRTDPVPEEGEDVAATIGATETLSEEEREELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGNKPAGGDFGEVLNSTASASATTTEPLPEQTQEGL", "length": 317, "header": "tr|A0AAA9SGV5-1|A0AAA9SGV5_BOVIN Isoform 1 of Tumor protein D52 OS=Bos taurus OX=9913 GN=TPD52 PE=3 SV=1 CANONICAL=A0AAA9SGV5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RU45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5/entry#A0AAA9RU45-1", "sequence": { "sequence": "EGAGASGVGAGPGAARLGARVRGAAARGLAPGQVRSLRCWSRQLRPRSRIPGLLRTDPVPEEGEDVAATIGATETLSEEEREELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGNKPAGGDFGEVLNSTASASATTTEPLPEQTQEGL", "length": 229, "header": "tr|A0AAA9RU45-1|A0AAA9SGV5_BOVIN Computationally mapped isoform of Tumor protein D52 OS=Bos taurus OX=9913 GN=TPD52 PE=3 SV=1 CANONICAL=A0AAA9SGV5-1" }, "locus": { "chromosome": "14", "start_pos": 43359793, "end_pos": 43231978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106994.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106994.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076653.1" } ] } }, { "isoform_ac": "A0AAA9S9L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5/entry#A0AAA9S9L7-1", "sequence": { "sequence": "MDGREMDFYEDYESPFDFNTGVNKNYLYLSPSGNTSPPGSPTLQKFGLLRTDPVPEEGEDVAATIGATETLSEEEREELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVNIRSIQHSISMPAMRNSPTFKSFEEKVENLKSKVGGNKPAGGDFGEVLNSTASASATTTEPLPEQTQEGL", "length": 238, "header": "tr|A0AAA9S9L7-1|A0AAA9SGV5_BOVIN Computationally mapped isoform of Tumor protein D52 OS=Bos taurus OX=9913 GN=TPD52 PE=3 SV=1 CANONICAL=A0AAA9SGV5-1" }, "locus": { "chromosome": "14", "start_pos": 43280735, "end_pos": 43231978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100666.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100666.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080620.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080620.1" } ] } }, { "isoform_ac": "A0AAA9S9P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5/entry#A0AAA9S9P1-1", "sequence": { "sequence": "MDGREMDFYEDYESPFDFNTGVNKNYLYLSPSGNTSPPGSPTLQKFGLLRTDPVPEEGEDVAATIGATETLSEEEREELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKLQAFSHSFRNSPTFKSFEEKVENLKSKVGGNKPAGGDFGEVLNSTASASATTTEPLPEQTQEGL", "length": 233, "header": "tr|A0AAA9S9P1-1|A0AAA9SGV5_BOVIN Computationally mapped isoform of Tumor protein D52 OS=Bos taurus OX=9913 GN=TPD52 PE=3 SV=1 CANONICAL=A0AAA9SGV5-1" }, "locus": { "chromosome": "14", "start_pos": 43280735, "end_pos": 43231978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135558.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135558.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080129.1" } ] } }, { "isoform_ac": "A0AAA9SGV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5/entry#A0AAA9SGV5-1", "sequence": { "sequence": "MINNLRVRRNAIPVSTRSPRSLHGAAASWPSPPSPLLQGGLQPALTRPSPPRRPAPPAGPPPAPTRRSAPARGVRWLGDAPGKRSPPRAGGATAPDASGGGDFPGAAGGGREERCAAGGRAGRAGTGCRREGDMDRSEQGLLRTDPVPEEGEDVAATIGATETLSEEEREELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGNKPAGGDFGEVLNSTASASATTTEPLPEQTQEGL", "length": 317, "header": "tr|A0AAA9SGV5-1|A0AAA9SGV5_BOVIN Isoform 1 of Tumor protein D52 OS=Bos taurus OX=9913 GN=TPD52 PE=3 SV=1 CANONICAL=A0AAA9SGV5-1" }, "locus": { "chromosome": "14", "start_pos": 43360213, "end_pos": 43231978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107216.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107216.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082925.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082925.1" } ] } }, { "isoform_ac": "E1BE76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV5/entry#E1BE76-1", "sequence": { "sequence": "MDGREMDFYEDYESPFDFNTGVNKNYLYLSPSGNTSPPGSPTLQKFGLLRTDPVPEEGEDVAATIGATETLSEEEREELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKLQAFSHSFSIRSIQHSISMPAMRNSPTFKSFEEKVENLKSKVGGNKPAGGDFGEVLNSTASASATTTEPLPEQTQEGL", "length": 247, "header": "tr|E1BE76-1|A0AAA9SGV5_BOVIN Computationally mapped isoform of Tumor protein D52 OS=Bos taurus OX=9913 GN=TPD52 PE=3 SV=2 CANONICAL=A0AAA9SGV5-1" }, "locus": { "chromosome": "14", "start_pos": 43280735, "end_pos": 43231978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055321.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055321.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049200.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049200.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B6B7-1", "protein_name": "Tumor protein D52 isoform X3", "gene_name": "tpd52", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEPVEDYKSPFNFEQGVNTSYLYLSPKESFTPPGSPVPPLRGTQRPDFIQEVGEEAVDAAPCSPCTVLTEQEQAELHSELQKVEEEIQTLSQVLAAKEKQVAEIKRKLGITPLNELKQNLSKGWHDVTTSTAYKKTSETLSQVGQKATTAFSSVGTAITRKLEDVRNTPSFKSFEEKVETLKTKMSPKPSTSDIEEVSDSTPDGEPMIKQPDDTFSPDQQPH", "length": 223 }, "evidence": [ { "id": "A0AAA9SGV5", "url": "https://omabrowser.org/oma/group/A0AAA9SGV5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0LBP7-1", "protein_name": "Tumor protein D52", "gene_name": "Tpd52", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTCSSLQTAFSVQAGAQWVEKGAVAKSESWEETFPVANLRWKSKRHGLAAACAASGSPSLPAPPLVFADLPHPCPAPPPEPTWRSAQVAVRWSVTPGTGSREGGADARGGDCAGGRGRSAERRGGARRAERRERGGSDMDRGEQGLLKTEPVAEEGEDAVAMLSAPETLTEEEQEELRRELTKVEEEIQTLSQVLAAKEKHLAEIKRKLGITSLQEFKQNIAKGWQDVTATNAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKLQAFSHSFSIRSIQHSISMPAMRNSPTFKSFEEKVENLKSKVGGAKPAGGDFGEVLNSTANATSTTTTEPPPEQTTESP", "length": 346 }, "evidence": [ { "id": "A0AAA9SGV5", "url": "https://omabrowser.org/oma/group/A0AAA9SGV5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RX99-1", "protein_name": "Tumor protein D52", "gene_name": "TPD52", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGSEMDFYEDYQSPFDFNTGVNKSYLYLSPNGNVSPPGSPALQKRGLLRTDPVPEEGEDVAATIGANEPLSEEEREELRRELTKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNLAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKYWLQPYCLFFSSLHRNSPTFKSFEEKVENLKSKVGGSKPAGGDFGDVLNSTANASATTTEPLPEQTQESL", "length": 239 }, "evidence": [ { "id": "A0AAA9SGV5", "url": "https://omabrowser.org/oma/group/A0AAA9SGV5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P55327-1", "protein_name": "Tumor protein D52", "gene_name": "TPD52", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDCREMDLYEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSPTLQKFGLLRTDPVPEEGEDVAATISATETLSEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGTKPAGGDFGEVLNSAANASATTTEPLPEKTQESL", "length": 224 }, "evidence": [ { "id": "A0AAA9SGV5", "url": "https://omabrowser.org/oma/group/A0AAA9SGV5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62393-1", "protein_name": "Tumor protein D52", "gene_name": "Tpd52", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MECRDMELADDYQSPFDFDSGVNKNYLYLSPSGNTSPPGSPTQNVGLLKTEPVAEEGEDAVTMLSAPEALTEEEQEELRRELTKVEEEIQTLSQVLAAKEKHLAELKRKLGISSLQEFKQNIAKGWQDVTATNAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGAKPAGGDFGEVLNSTANATSTMTTEPPPEQMTESP", "length": 224 }, "evidence": [ { "id": "A0AAA9SGV5", "url": "https://omabrowser.org/oma/group/A0AAA9SGV5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 296, "end_pos": 298 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SE98-1", "uniprot_ac": "A0AAA9SE98", "uniprot_id": "A0AAA9SE98_BOVIN", "mass": { "chemical_mass": 63284.0, "monoisotopic_mass": 63284.0 }, "refseq": { "ac": "XP_059737590", "name": "F-box only protein 24 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737590" }, "gene_names": [ { "name": "FBXO24", "type": "recommended", "evidence": [ { "id": "A0AAA9SE98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" } ] }, { "name": "FBXO24", "type": "synonym", "evidence": [ { "id": "XP_059737590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737590" } ] } ], "protein_names": [ { "name": "F-box only protein 24 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059737590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737590" } ] }, { "name": "F-box protein 24", "type": "synonym", "evidence": [ { "id": "A0AAA9SE98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98", "locus": { "chromosome": "25", "start_pos": 35959543, "end_pos": 35971109, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003169", "url": "https://www.ensembl.org/id/ENSBTAG00000003169" } ] } } ], "crossref": [ { "id": "A0AAA9SE98", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SE98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22098", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22098", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "107131855", "url": "https://www.ncbi.nlm.nih.gov/gene/107131855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N0D2", "url": "https://www.orthodb.org/?gene=F1N0D2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47004", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47004", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47004:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47004:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00415", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00415", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059737590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0D2", "url": "https://www.uniprot.org/uniprotkb/F1N0D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0D2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0D2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKRSCPSCGPSEPGGEEKKGRGNPVSVQLFPPELVEHIISFLPVRDVVALGQTCHYFHQVCDAESVWRRICHRLSPRLREQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPQLAHGYRRFLPTKDHVFILDYAGTLFFLKNALVSSTLGQIQWKRACRYIVLCRGAKDFASDPRCDTVYRKYLYVLATREQPGVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVACMASNQSSTLYITDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQRPIALWCGLNHSLVLSQGSDFSKELLGCGCGAGGRLPGWPKGSASFVKLHIKVPLCACSLCSTRECLYMLSSHDIEHHPAYRDLPASKAVGTPEPSLGAGAPQDPGGVAWACEEYLSQIHNCPTLQDRMEKMKEIVGWMPLMAAQKDFFWEALDMLQRAAGGAGQGPPPPES", "length": 569, "header": "tr|A0AAA9SE98-1|A0AAA9SE98_BOVIN Isoform 1 of F-box protein 24 OS=Bos taurus OX=9913 GN=FBXO24 PE=4 SV=1 CANONICAL=A0AAA9SE98-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98/entry#A0AAA9SDQ4-1", "sequence": { "sequence": "MGEKKAAPPPPSLRRRRVKRSCPSCGPSEPGGEEKKGRGNPVSVQLFPPELVEHIISFLPVRDVVALGQTCHYFHQVCDAESVWRRICHRLSPRLREQDTKGLYFQAFGGRRRCLSKSVAPQLAHGYRRFLPTKDHVFILDYAGTLFFLKNALVSSTLGQIQWKRACRYIVLCRGAKDFASDPRCDTVYRKYLYVLATREQPGVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVACMASNQSSTLYITDPILCSWLQSPWPGG", "length": 324, "header": "tr|A0AAA9SDQ4-1|A0AAA9SE98_BOVIN Computationally mapped isoform of F-box protein 24 OS=Bos taurus OX=9913 GN=FBXO24 PE=4 SV=1 CANONICAL=A0AAA9SE98-1" }, "locus": { "chromosome": "25", "start_pos": 35971109, "end_pos": 35964472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111302.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111302.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081942.1" } ] } }, { "isoform_ac": "A0AAA9SE98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98/entry#A0AAA9SE98-1", "sequence": { "sequence": "MVKRSCPSCGPSEPGGEEKKGRGNPVSVQLFPPELVEHIISFLPVRDVVALGQTCHYFHQVCDAESVWRRICHRLSPRLREQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPQLAHGYRRFLPTKDHVFILDYAGTLFFLKNALVSSTLGQIQWKRACRYIVLCRGAKDFASDPRCDTVYRKYLYVLATREQPGVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVACMASNQSSTLYITDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQRPIALWCGLNHSLVLSQGSDFSKELLGCGCGAGGRLPGWPKGSASFVKLHIKVPLCACSLCSTRECLYMLSSHDIEHHPAYRDLPASKAVGTPEPSLGAGAPQDPGGVAWACEEYLSQIHNCPTLQDRMEKMKEIVGWMPLMAAQKDFFWEALDMLQRAAGGAGQGPPPPES", "length": 569, "header": "tr|A0AAA9SE98-1|A0AAA9SE98_BOVIN Isoform 1 of F-box protein 24 OS=Bos taurus OX=9913 GN=FBXO24 PE=4 SV=1 CANONICAL=A0AAA9SE98-1" }, "locus": { "chromosome": "25", "start_pos": 35969297, "end_pos": 35960547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127104.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127104.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080717.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080717.1" } ] } }, { "isoform_ac": "A0AAA9T0H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98/entry#A0AAA9T0H6-1", "sequence": { "sequence": "MGEKKAAPPPPSLRRRRVKRSCPSCGPSEPGGEEKKGRGNPVSVQLFPPELVEHIISFLPVRDVVALGQTCHYFHQVCDAESVWRRICHRLSPRLREQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPQLAHGYRRFLPTKDHVFILDYAGTLFFLKNALVSSTLGQIQWKRACRYIVLCRGAKDFASDPRCDTVYRKYLYVLATREQPGVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVACMASNQSSTLYITDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQRPIALWCGLNHSLVLSQGSDFSKELLGCGCGAGGRLPGWPKGSASFVKLHIKVPLCACSLCSTRECLYMLSSHDIEHHPAYRDLPASKAVGTPEPSLGAGAPQDPGGVAWACEEYLSQIHNCPTLQDRMEKMKEIVGWMPLMAAQKDFFWEALDMLQRAAGGAGQGPPPPES", "length": 585, "header": "tr|A0AAA9T0H6-1|A0AAA9T0H6_BOVIN Computationally mapped isoform of F-box protein 24 OS=Bos taurus OX=9913 GN=FBXO24 PE=4 SV=1 CANONICAL=A0AAA9SE98-1" }, "locus": { "chromosome": "25", "start_pos": 35971109, "end_pos": 35960547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089883.1" } ] } }, { "isoform_ac": "F1N0D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98/entry#F1N0D2-1", "sequence": { "sequence": "MVWERQQGRGGRGARRDEGRSREGAVRMVRRSRSRKLQKLTGLCRREEGLRVKRSCPSCGPSEPGGEEKKGRGNPVSVQLFPPELVEHIISFLPVRDVVALGQTCHYFHQVCDAESVWRRICHRLSPRLREQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPQLAHGYRRFLPTKDHVFILDYAGTLFFLKNALVSSTLGQIQWKRACRYIVLCRGAKDFASDPRCDTVYRKYLYVLATREQPGVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVACMASNQSSTLYITDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQRPIALWCGLNHSLVLSQGSDFSKELLGCGCGAGGRLPGWPKGSASFVKLHIKVPLCACSLCSTRECLYMLSSHDIEHHPAYRDLPASKAVGTPEPSLGAGAPQDPGGVAWACEEYLSQIHNCPTLQDRMEKMKEIVGWMPLMAAQKDFFWEALDMLQRAAGGAGQGPPPPES", "length": 619, "header": "tr|F1N0D2-1|A0AAA9SE98_BOVIN Computationally mapped isoform of F-box protein 24 OS=Bos taurus OX=9913 GN=FBXO24 PE=4 SV=4 CANONICAL=A0AAA9SE98-1" }, "locus": { "chromosome": "25", "start_pos": 35969297, "end_pos": 35960547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004115.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004115.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004115.5", "url": "https://www.ensembl.org/id/ENSBTAP00000004115.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SE98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SE98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE98" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 71, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFD6-1", "uniprot_ac": "A0AAA9SFD6", "uniprot_id": "A0AAA9SFD6_BOVIN", "mass": { "chemical_mass": 28185.0, "monoisotopic_mass": 28185.0 }, "refseq": {}, "gene_names": [ { "name": "MCL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ] } ], "protein_names": [ { "name": "MCL1 apoptosis regulator, BCL2 family member", "type": "synonym", "evidence": [ { "id": "A0AAA9SFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TLY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLY8#function" }, { "database": "UniProtKB", "id": "ARBA00057384", "url": "https://www.uniprot.org/uniprotkb/ARBA00057384#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6", "locus": { "chromosome": "3", "start_pos": 20134008, "end_pos": 20129298, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015154", "url": "https://www.ensembl.org/id/ENSBTAG00000015154" } ] } } ], "crossref": [ { "id": "A0AAA9SFD6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06845", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06845", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11256", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11256:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11256:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGLKRNAVIGLNLYCGGAGLGQGSGASSPGGRLLAAGKEATARREVGGGEAGTVIGGSAGPSPPATLAPDARRVARPSPIGAEGPDVTATPTRLLFFAPTRLASPPEEMESPISDAIMSPEEELDGCEPDPLGKRPAVRPLPLLVGEASNNSPGSDGSLPSTPPPAEEEEDELYRQSLEIISQYLREQATGAKDAKPLGGSGTTSRKALETLRRVGDGVQRNHETAFQGWVCGVLPCRGPRRRHQKCAAGFCRCCRSRSWFGISNKIAF", "length": 270, "header": "tr|A0AAA9SFD6-1|A0AAA9SFD6_BOVIN Isoform 1 of MCL1 apoptosis regulator, BCL2 family member OS=Bos taurus OX=9913 GN=MCL1 PE=4 SV=1 CANONICAL=A0AAA9SFD6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6/entry#A0AAA9SFD6-1", "sequence": { "sequence": "MFGLKRNAVIGLNLYCGGAGLGQGSGASSPGGRLLAAGKEATARREVGGGEAGTVIGGSAGPSPPATLAPDARRVARPSPIGAEGPDVTATPTRLLFFAPTRLASPPEEMESPISDAIMSPEEELDGCEPDPLGKRPAVRPLPLLVGEASNNSPGSDGSLPSTPPPAEEEEDELYRQSLEIISQYLREQATGAKDAKPLGGSGTTSRKALETLRRVGDGVQRNHETAFQGWVCGVLPCRGPRRRHQKCAAGFCRCCRSRSWFGISNKIAF", "length": 270, "header": "tr|A0AAA9SFD6-1|A0AAA9SFD6_BOVIN Isoform 1 of MCL1 apoptosis regulator, BCL2 family member OS=Bos taurus OX=9913 GN=MCL1 PE=4 SV=1 CANONICAL=A0AAA9SFD6-1" }, "locus": { "chromosome": "3", "start_pos": 20131371, "end_pos": 20129432, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098196.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098196.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081166.1" } ] } }, { "isoform_ac": "A0AAA9TLY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6/entry#A0AAA9TLY8-1", "sequence": { "sequence": "MFGLKRNAVIGLNLYCGGAGLGQGSGASSPGGRLLATGAKDAKPLGGSGTTSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMVHVFSDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRSKRDWIVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR", "length": 196, "header": "tr|A0AAA9TLY8-1|A0AAA9TLY8_BOVIN Computationally mapped isoform of MCL1 apoptosis regulator, BCL2 family member OS=Bos taurus OX=9913 GN=MCL1 PE=3 SV=1 CANONICAL=A0AAA9SFD6-1" }, "locus": { "chromosome": "3", "start_pos": 20131363, "end_pos": 20129432, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091412.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091412.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097974.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097974.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "BH domain binding", "id": "GO:0051400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051400", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SET5-1", "uniprot_ac": "A0AAA9SET5", "uniprot_id": "A0AAA9SET5_BOVIN", "mass": { "chemical_mass": 17668.0, "monoisotopic_mass": 17668.0 }, "refseq": {}, "gene_names": [ { "name": "SFT2D2", "type": "recommended", "evidence": [ { "id": "A0AAA9SET5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ] } ], "protein_names": [ { "name": "Vesicle transport protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SET5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY7#function" }, { "database": "UniProtKB", "id": "RU363111", "url": "https://www.uniprot.org/uniprotkb/RU363111#function" }, { "database": "UniProtKB", "id": "ARBA00003566", "url": "https://www.uniprot.org/uniprotkb/ARBA00003566#function" }, { "database": "UniProtKB", "id": "A0AAA9S4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4P8#function" }, { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5#function" }, { "database": "UniProtKB", "id": "F6RF48", "url": "https://www.uniprot.org/uniprotkb/F6RF48#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SFT2D2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5", "locus": { "chromosome": "3", "start_pos": 308778, "end_pos": 330047, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037819", "url": "https://www.ensembl.org/id/ENSBTAG00000037819" } ] } } ], "crossref": [ { "id": "A0AAA9SET5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SET5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037819", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037819", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6RF48", "url": "https://www.orthodb.org/?gene=F6RF48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23137:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23137:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SET5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RF48", "url": "https://www.uniprot.org/uniprotkb/F6RF48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RF48-1", "url": "https://www.uniprot.org/uniprotkb/F6RF48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VRRGPRRAPSPPPSSAGSCCWLVVEATSLSSGTRIKGFIACFAAGILCSLLGTLLLWVPRKGLYLFAVFYTFGNIASLGSTVFLMGPMTQLKRMFEPTRLIATVLVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSYIPFARDAVKKCFTVCLA", "length": 161, "header": "tr|A0AAA9SET5-1|A0AAA9SET5_BOVIN Isoform 1 of Vesicle transport protein OS=Bos taurus OX=9913 GN=SFT2D2 PE=3 SV=1 CANONICAL=A0AAA9SET5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5/entry#A0AAA9S4P8-1", "sequence": { "sequence": "MDKLKKVLSGQDSEDRGGLSEVVEATSLSSGTRIKGFIACFAAGILCSLLGTLLLWVPRKGLYLFAVFYTFGNIASLGSTVFLMGPMTQLKRMFEPTRLIATVLVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSYIPFASWS", "length": 150, "header": "tr|A0AAA9S4P8-1|A0AAA9SET5_BOVIN Computationally mapped isoform of Vesicle transport protein OS=Bos taurus OX=9913 GN=SFT2D2 PE=3 SV=1 CANONICAL=A0AAA9SET5-1" }, "locus": { "chromosome": "3", "start_pos": 330008, "end_pos": 309762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102985.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102985.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078802.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078802.1" } ] } }, { "isoform_ac": "A0AAA9SET5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5/entry#A0AAA9SET5-1", "sequence": { "sequence": "VRRGPRRAPSPPPSSAGSCCWLVVEATSLSSGTRIKGFIACFAAGILCSLLGTLLLWVPRKGLYLFAVFYTFGNIASLGSTVFLMGPMTQLKRMFEPTRLIATVLVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSYIPFARDAVKKCFTVCLA", "length": 161, "header": "tr|A0AAA9SET5-1|A0AAA9SET5_BOVIN Isoform 1 of Vesicle transport protein OS=Bos taurus OX=9913 GN=SFT2D2 PE=3 SV=1 CANONICAL=A0AAA9SET5-1" }, "locus": { "chromosome": "3", "start_pos": 329865, "end_pos": 314443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113878.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113878.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083907.1" } ] } }, { "isoform_ac": "A0AAA9STY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5/entry#A0AAA9STY7-1", "sequence": { "sequence": "MDKLKKVLSGQDSEDRGGLSEVVEATSLSSGTRIKGFIACFAAGILCSLLGTLLLWVPRKGLYLFAVFYTFGNIASLGSCVLHLPCVLPFGGTTKGLLSSSAFCSLWP", "length": 108, "header": "tr|A0AAA9STY7-1|A0AAA9SET5_BOVIN Computationally mapped isoform of Vesicle transport protein OS=Bos taurus OX=9913 GN=SFT2D2 PE=3 SV=1 CANONICAL=A0AAA9SET5-1" }, "locus": { "chromosome": "3", "start_pos": 330008, "end_pos": 318214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119097.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119097.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089885.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089885.1" } ] } }, { "isoform_ac": "F6RF48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5/entry#F6RF48-1", "sequence": { "sequence": "MDKLKKVLSGQDSEDRGGLSEVVEATSLSSGTRIKGFIACFAAGILCSLLGTLLLWVPRKGLYLFAVFYTFGNIASLGSTVFLMGPMTQLKRMFEPTRLIATVLVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWDAVKKCFTVCLA", "length": 150, "header": "tr|F6RF48-1|F6RF48_BOVIN Computationally mapped isoform of Vesicle transport protein OS=Bos taurus OX=9913 GN=SFT2D2 PE=3 SV=2 CANONICAL=A0AAA9SET5-1" }, "locus": { "chromosome": "3", "start_pos": 330008, "end_pos": 314443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057251.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057251.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050284.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050284.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG01-1", "uniprot_ac": "A0AAA9SG01", "uniprot_id": "A0AAA9SG01_BOVIN", "mass": { "chemical_mass": 117634.0, "monoisotopic_mass": 117634.0 }, "refseq": {}, "gene_names": [ { "name": "ERN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "type": "recommended", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#names_and_taxonomy" } ] }, { "name": "Endoplasmic reticulum-to-nucleus signaling 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#names_and_taxonomy" } ] }, { "name": "Inositol-requiring protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#names_and_taxonomy" } ] }, { "name": "Ire1-alpha", "type": "synonym", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ERN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01", "locus": { "chromosome": "19", "start_pos": 48272413, "end_pos": 48350909, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016799", "url": "https://www.ensembl.org/id/ENSBTAG00000016799" } ] } } ], "crossref": [ { "id": "A0AAA9SG01", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016799", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10422", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10422", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13982", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13982", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MM00", "url": "https://www.orthodb.org/?gene=F1MM00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13954", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13954", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13954:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13954:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06479", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06479", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381070", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381070", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM00", "url": "https://www.uniprot.org/uniprotkb/F1MM00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM00-1", "url": "https://www.uniprot.org/uniprotkb/F1MM00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRLAAAAAPGFVRPPGRRRRWAGRGGLLTGRSGGHGRPRRGVRHPGASRAGAAVTSSASRAACSPTQLCVVLAAPQGVQKARGPWEAVPPVGPFPQGFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAAALPEDGGDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVIDLVDQTSENAPTTVSPDVEEKFDHAPAKPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSIHQQRQLQHQQFQKELEKIQLLQQQQLPFHPPGDAAQDAELQDSSGQYSESSATSSPSTSPRASNHSLHSTGCTSKAVTSPFLEQDDEDEETGMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGSSVRDLLRAMRNKKHHYRELPEEVQQTLGALPDDFVRYFTSRFPHLLSHTYRAMELCCHERPFQPYYHEPPEPQPPVTADAL", "length": 1053, "header": "tr|A0AAA9SG01-1|A0AAA9SG01_BOVIN Isoform 1 of Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Bos taurus OX=9913 GN=ERN1 PE=4 SV=1 CANONICAL=A0AAA9SG01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#A0AAA9SG01-1", "sequence": { "sequence": "MRRLAAAAAPGFVRPPGRRRRWAGRGGLLTGRSGGHGRPRRGVRHPGASRAGAAVTSSASRAACSPTQLCVVLAAPQGVQKARGPWEAVPPVGPFPQGFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAAALPEDGGDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVIDLVDQTSENAPTTVSPDVEEKFDHAPAKPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSIHQQRQLQHQQFQKELEKIQLLQQQQLPFHPPGDAAQDAELQDSSGQYSESSATSSPSTSPRASNHSLHSTGCTSKAVTSPFLEQDDEDEETGMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGSSVRDLLRAMRNKKHHYRELPEEVQQTLGALPDDFVRYFTSRFPHLLSHTYRAMELCCHERPFQPYYHEPPEPQPPVTADAL", "length": 1053, "header": "tr|A0AAA9SG01-1|A0AAA9SG01_BOVIN Isoform 1 of Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Bos taurus OX=9913 GN=ERN1 PE=4 SV=1 CANONICAL=A0AAA9SG01-1" }, "locus": { "chromosome": "19", "start_pos": 48350502, "end_pos": 48273417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099924.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099924.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081399.1" } ] } }, { "isoform_ac": "A0AAA9SWS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#A0AAA9SWS9-1", "sequence": { "sequence": "MLVRLLLLLLLALLLPGPGGFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAAALPEDGGDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPCTGILLSHRPPQPHSGLSSQPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVIDLVDQTSENAPTTVSPDVEEKFDHAPAKPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSIHQQRQLQHQQFQKELEKIQLLQQQQLPFHPPGDAAQDAELQDSSGQYSESSATSSPSTSPRASNHSLHSTGCTSKAVTSPFLEQDDEDEETGMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGSSVRDLLRAMRNKKHHYRELPEEVQQTLGALPDDFVRYFTSRFPHLLSHTYRAMELCCHERPFQPYYHEPPEPQPPVTADAL", "length": 996, "header": "tr|A0AAA9SWS9-1|A0AAA9SG01_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Bos taurus OX=9913 GN=ERN1 PE=4 SV=1 CANONICAL=A0AAA9SG01-1" }, "locus": { "chromosome": "19", "start_pos": 48350621, "end_pos": 48273417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098164.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098164.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088520.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088520.1" } ] } }, { "isoform_ac": "F1MM00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01/entry#F1MM00-1", "sequence": { "sequence": "MLVRLLLLLLLALLLPGPGGFGSPSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAAALPEDGGDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYIWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVIDLVDQTSENAPTTVSPDVEEKFDHAPAKPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSIHQQRQLQHQQFQKELEKIQLLQQQQLPFHPPGDAAQDAELQDSSGQYSESSATSSPSTSPRASNHSLHSTGCTSKAVTSPFLEQDDEDEETGMVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVKQLERGGRAVVKMDWRENITVPLQTGDHEVPRAWARRFLVNTSEKQ", "length": 904, "header": "tr|F1MM00-1|F1MM00_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=ERN1 PE=4 SV=4 CANONICAL=A0AAA9SG01-1" }, "locus": { "chromosome": "19", "start_pos": 48350621, "end_pos": 48274553, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022347.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022347.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022347.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022347.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-381070", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381070", "resource": "Reactome", "description": "IRE1alpha activates chaperones" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "positive regulation of RNA splicing", "id": "GO:0033120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033120", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "IRE1-mediated unfolded protein response", "id": "GO:0036498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036498", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "positive regulation of response to endoplasmic reticulum stress", "id": "GO:1905898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "mRNA splicing, via endonucleolytic cleavage and ligation", "id": "GO:0070054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "insulin metabolic process", "id": "GO:1901142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901142", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "positive regulation of vascular associated smooth muscle cell proliferation", "id": "GO:1904707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904707", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "endothelial cell proliferation", "id": "GO:0001935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001935", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "cellular response to vascular endothelial growth factor stimulus", "id": "GO:0035924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "positive regulation of endoplasmic reticulum unfolded protein response", "id": "GO:1900103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900103", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "id": "GO:0070059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 13, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "platelet-derived growth factor receptor binding", "id": "GO:0005161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "ADP binding", "id": "GO:0043531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043531", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "Hsp90 protein binding", "id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "Hsp70 protein binding", "id": "GO:0030544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "IRE1-TRAF2-ASK1 complex", "id": "GO:1990604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "IRE1-RACK1-PP2A complex", "id": "GO:1990630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "AIP1-IRE1 complex", "id": "GO:1990597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" }, { "start_pos": 954, "end_pos": 956, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-381091", "name": "IRE1 dimer autophosphorylates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SG01-1" ], "evidence": [ { "id": "R-BTA-381091", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381091" } ] }, { "id": "R-BTA-381109", "name": "IRE1 binds IRE1 forming dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SG01-1" ], "evidence": [ { "id": "R-BTA-381109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381109" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" }, { "id": "PS51392", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51392" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KEN", "eco_id": "ECO_0000259", "start_pos": 912, "end_pos": 1040, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 648, "end_pos": 909, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 }, { "start_pos": 611, "end_pos": 613 }, { "start_pos": 954, "end_pos": 956 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHZ2-1", "uniprot_ac": "A0AAA9SHZ2", "uniprot_id": "A0AAA9SHZ2_BOVIN", "mass": { "chemical_mass": 76009.0, "monoisotopic_mass": 76009.0 }, "refseq": { "ac": "NP_001421943", "name": "CAP-Gly domain-containing linker protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421943" }, "gene_names": [ { "name": "CLIP4", "type": "recommended", "evidence": [ { "id": "A0AAA9SHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ] }, { "name": "CLIP4", "type": "synonym", "evidence": [ { "id": "NP_001421943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421943" } ] } ], "protein_names": [ { "name": "CAP-GLY domain containing linker protein family, member 4", "type": "synonym", "evidence": [ { "id": "NP_001421943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421943" } ] }, { "name": "CAP-Gly domain containing linker protein family member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2/entry#names_and_taxonomy" } ] }, { "name": "CAP-Gly domain-containing linker protein 4", "type": "synonym", "evidence": [ { "id": "NP_001421943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421943" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLIP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2", "locus": { "chromosome": "11", "start_pos": 70661859, "end_pos": 70747621, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007378", "url": "https://www.ensembl.org/id/ENSBTAG00000007378" } ] } } ], "crossref": [ { "id": "A0AAA9SHZ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007378", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007378", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515213", "url": "https://www.ncbi.nlm.nih.gov/gene/515213", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FTCKTNH", "url": "https://omabrowser.org/oma/group/FTCKTNH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MUQ4", "url": "https://www.orthodb.org/?gene=F1MUQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18916", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18916", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18916:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18916:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01302", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01302", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421943", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSA7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUQ4", "url": "https://www.uniprot.org/uniprotkb/F1MUQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUQ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MUQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTIEDLPDFPLEGSSLIGKYPFLFQGSDTPVIFSISAAPMPSDCEFSFFDPNDTSCQEILFDPKTSVSELFAILRQWVPQVQQNIDVIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVDTAVKFATQLIDLGADVSLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGTVKCLLEHGANPAFRNDKGQIPADVVPDPVEMPLEMADAAATAKEIKQMLLDAAPLSYDLSKPLLPNYDRVTSKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKDRRKNIAHTPSTKAGPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTGAEKDVPLIGSISSSSSISSLEHKQSLSKKLNARGNNKKTMSKSPSLSSRASAGLNSSAASVANSGRCEGDLRIGDRVLVAGQRIGAIKFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFAKSKPTLHRSWSSSSTAGGLEGSVKLHEGSQVLLTSSNEMATVRYVGPTDFASGIWLGLELRSPKGKNDGAVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC", "length": 704, "header": "tr|A0AAA9SHZ2-1|A0AAA9SHZ2_BOVIN Isoform 1 of CAP-Gly domain containing linker protein family member 4 OS=Bos taurus OX=9913 GN=CLIP4 PE=4 SV=1 CANONICAL=A0AAA9SHZ2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2/entry#A0A3Q1LSA7-1", "sequence": { "sequence": "MTIEDLPDFPLEGSSLIGKYPFLFQGSDTPVIFSISAAPMPSDCEFSFFDPNDTSCQEILFDPKTSVSELFAILRQWVPQVQQNIDVIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVDTAVKFATQLIDLGADVSLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGTVKCLLEHGANPAFRNDKGQIPADVVPDPVEMPLEMADAAATAKEIKQMLLDAAPLSYDLSKPLLPNYDRVTSKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKDRRKNIAHTPSTKAGPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTGAEKDVPLIGSISSSSSISSLEHKQSLSKKLNARGNNKKTMSKSPSLSSRASAGLNSSAASVANSGRCEGDLRIGDRVLVAGQRIGAIKFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGQSPPCTAAGAAARRPAAWRVA", "length": 595, "header": "tr|A0A3Q1LSA7-1|A0AAA9SHZ2_BOVIN Computationally mapped isoform of CAP-Gly domain containing linker protein family member 4 OS=Bos taurus OX=9913 GN=CLIP4 PE=4 SV=1 CANONICAL=A0AAA9SHZ2-1" }, "locus": { "chromosome": "11", "start_pos": 70727053, "end_pos": 70671467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074213.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074213.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057957.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057957.2" } ] } }, { "isoform_ac": "A0AAA9SHZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2/entry#A0AAA9SHZ2-1", "sequence": { "sequence": "MTIEDLPDFPLEGSSLIGKYPFLFQGSDTPVIFSISAAPMPSDCEFSFFDPNDTSCQEILFDPKTSVSELFAILRQWVPQVQQNIDVIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVDTAVKFATQLIDLGADVSLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGTVKCLLEHGANPAFRNDKGQIPADVVPDPVEMPLEMADAAATAKEIKQMLLDAAPLSYDLSKPLLPNYDRVTSKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKDRRKNIAHTPSTKAGPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTGAEKDVPLIGSISSSSSISSLEHKQSLSKKLNARGNNKKTMSKSPSLSSRASAGLNSSAASVANSGRCEGDLRIGDRVLVAGQRIGAIKFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFAKSKPTLHRSWSSSSTAGGLEGSVKLHEGSQVLLTSSNEMATVRYVGPTDFASGIWLGLELRSPKGKNDGAVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC", "length": 704, "header": "tr|A0AAA9SHZ2-1|A0AAA9SHZ2_BOVIN Isoform 1 of CAP-Gly domain containing linker protein family member 4 OS=Bos taurus OX=9913 GN=CLIP4 PE=4 SV=1 CANONICAL=A0AAA9SHZ2-1" }, "locus": { "chromosome": "11", "start_pos": 70727053, "end_pos": 70671213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089315.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089315.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083511.1" } ] } }, { "isoform_ac": "A0AAA9TKX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2/entry#A0AAA9TKX3-1", "sequence": { "sequence": "MTIEDLPDFPLEGSSLIGKYPFLFQGSDTPVIFSISAAPMPSDCEFSFFDPNDTSCQEILFDPKTSVSELFAILRQWVPQVQQNIDVIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIV", "length": 123, "header": "tr|A0AAA9TKX3-1|A0AAA9TKX3_BOVIN Computationally mapped isoform of CAP-Gly domain containing linker protein family member 4 OS=Bos taurus OX=9913 GN=CLIP4 PE=4 SV=2 CANONICAL=A0AAA9SHZ2-1" }, "locus": { "chromosome": "11", "start_pos": 70727053, "end_pos": 70721360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100527.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100527.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099060.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099060.2" } ] } }, { "isoform_ac": "A0AAA9TL23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2/entry#A0AAA9TL23-1", "sequence": { "sequence": "MTIEDLPDFPLEGSSLIGKYPFLFQGSDTPVIFSISAAPMPSDCEFSFFDPNDTSCQEILFDPKTSVSELFAILRQWVPQVQQNIDVIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVDTAVKFATQLIDLGADVSLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGTVKCLLEHGANPAFRNDKGQIPADVVPDPVEMPLEMADAAATAKEIKQMLLDAAPLSYDLSKPLLPNYDRVTSKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKDRRKNIAHTPSTKAGPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTGAEKDVPLIGSISSSSSISSLEHKQSLSKKLNARGNNKKTMSKSPSLSSRASAGQSPPCTAAGAAARRPAAWRVA", "length": 487, "header": "tr|A0AAA9TL23-1|A0AAA9TL23_BOVIN Computationally mapped isoform of CAP-Gly domain containing linker protein family member 4 OS=Bos taurus OX=9913 GN=CLIP4 PE=4 SV=2 CANONICAL=A0AAA9SHZ2-1" }, "locus": { "chromosome": "11", "start_pos": 70727053, "end_pos": 70671467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123721.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123721.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099121.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099121.2" } ] } }, { "isoform_ac": "F1MUQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2/entry#F1MUQ4-1", "sequence": { "sequence": "MTIEDLPDFPLEGSSLIGKYPFLFQGSDTPVIFSISAAPMPSDCEFSFFDPNDTSCQEILFDPKTSVSELFAILRQWVPQVQQNIDVIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVDTAVKFATQLIDLGADVSLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGTVKCLLEHGANPAFRNDKGQIPADVVPDPVEMPLEMADAAATAKEIKQMLLDAAPLSYDLSKPLLPNYDRVTSKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKDRRKNIAHTPSTKAGPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTGAEKDVPLIGSISSSSSISSLEHKQSLSKKLNARGNNKKTMSKSPSLSSRASAGLNSSAASVANSGRCEGDLRIGDRVLVAGQRIGAIKFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFAKSKPTLHRSWSSSSTAGGLEGSVKLHEGSQVLLTSSNEMATVSLWKNIGILVFVLYVHTTAQEPSAAVKLAKSSCVFFGDPFK", "length": 680, "header": "tr|F1MUQ4-1|F1MUQ4_BOVIN Computationally mapped isoform of CAP-Gly domain containing linker protein family member 4 OS=Bos taurus OX=9913 GN=CLIP4 PE=4 SV=2 CANONICAL=A0AAA9SHZ2-1" }, "locus": { "chromosome": "11", "start_pos": 70727053, "end_pos": 70664531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009702.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009702.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009702.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009702.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 645, "start_aa": "Thr", "end_pos": 645, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr645", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8CI96-1", "protein_name": "CAP-Gly domain-containing linker protein 4", "gene_name": "Clip4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTIEDLPDIPLEGSSLIGRYPFLFTGSDTSVIFSISAAPMPSDCEFSFFDPNDASCQEILFDPKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDIETAVKFAAQLIDLGADASLRSRWTNMNALHYASYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAHNLCAGAVKTLLELGANPAFRNDKGQIPAEVVPDPVDMPLEMADAAAIAKEIKQMLLDAVPLPCTSAKAVLPNSDHTTSRAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGRVQYFKCAPKYGIFAPLSKISKLKDGRKTTTHTPSTRATPHARSQKVDVAHFTSRVNSGLTTSKKETASESTLTLPPSEEPKTVAENDAAQPGSMSSSSSSSSLDHKQSYPKKLTTSSGGKKTLSKSPSLPSRASAGLKSSATSAANNSHHEGALHLGERVLVVGQRVGTIKFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRLSDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFAKTKTTLRRSWSSSTTAGGLEGTVKLHEGSQVLLTSSNEMATVRYVGPTDFASGIWLGLELRSAKGKNDGAVGDKRYFTCKPNYGVLVRPSRVTYRGISGSKLIDENC", "length": 704 }, "evidence": [ { "id": "A0AAA9SHZ2", "url": "https://omabrowser.org/oma/group/A0AAA9SHZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ], "pmid": "" }, { "name": "microtubule plus-end", "id": "GO:0035371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035371", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule plus-end binding", "id": "GO:0051010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 695, "end_pos": 697, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ2" }, { "id": "PS50245", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50245" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CAP-Gly", "eco_id": "ECO_0000259", "start_pos": 303, "end_pos": 345, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 645 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 325, "end_pos": 327 }, { "start_pos": 468, "end_pos": 470 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 695, "end_pos": 697 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEM3-1", "uniprot_ac": "A0AAA9SEM3", "uniprot_id": "A0AAA9SEM3_BOVIN", "mass": { "chemical_mass": 52150.0, "monoisotopic_mass": 52150.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF385D", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3" } ] } ], "protein_names": [ { "name": "Zinc finger protein 385D", "type": "synonym", "evidence": [ { "id": "A0AAA9SEM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF385D", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3", "locus": { "chromosome": "27", "start_pos": 44434136, "end_pos": 43450414, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050535", "url": "https://www.ensembl.org/id/ENSBTAG00000050535" } ] } } ], "crossref": [ { "id": "A0AAA9SEM3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050535", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050535", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "789528", "url": "https://www.ncbi.nlm.nih.gov/gene/789528", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RNIMYFX", "url": "https://omabrowser.org/oma/group/RNIMYFX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTJ6", "url": "https://www.orthodb.org/?gene=A0A3Q1LTJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23067", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23067", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23067:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23067:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LTJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGPGRRAAAGRKMKGSAGGRREKPLGSPPAPPGPDSTCVQDGECEAEFPPDGFEEKPEKEKKQTNFTLCSVCNIQLNSTAQAQIHYNGKSHQKRLKQLSTGLVKNDTGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLRALEATKTKQKPVTAKDSAKTTFTSITTNTINASSDKTDSTTGTPAISTTTVEIRKSSVMTTEITSKVEKSPTTASGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGAIKAFPRAGVKGKGPANKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLAPRLLPGPLAAAAAAVAVSSPFGLRAAPPALLPALPPALLRPAPGPMRSAHAPVLFAPY", "length": 490, "header": "tr|A0AAA9SEM3-1|A0AAA9SEM3_BOVIN Isoform 1 of Zinc finger protein 385D OS=Bos taurus OX=9913 GN=ZNF385D PE=4 SV=1 CANONICAL=A0AAA9SEM3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3/entry#A0A3Q1LTJ6-1", "sequence": { "sequence": "MLSFCGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLRALEATKTKQKPVTAKDSAKTTFTSITTNTINASSDKTDSTTGTPAISTTTVEIRKSSVMTTEITSKVEKSPTTASGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGAIKAFPRAGVKGKGPANKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLAPRLLPGPLAAAAAAVAVSSPFGLRAAPPALLPALPPALLRPAPGPMRSAHAPVLFAPY", "length": 386, "header": "tr|A0A3Q1LTJ6-1|A0AAA9SEM3_BOVIN Computationally mapped isoform of Zinc finger protein 385D OS=Bos taurus OX=9913 GN=ZNF385D PE=4 SV=1 CANONICAL=A0AAA9SEM3-1" }, "locus": { "chromosome": "27", "start_pos": 44433976, "end_pos": 44087430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075139.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075139.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060653.1" } ] } }, { "isoform_ac": "A0AAA9SEM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3/entry#A0AAA9SEM3-1", "sequence": { "sequence": "MPGPGRRAAAGRKMKGSAGGRREKPLGSPPAPPGPDSTCVQDGECEAEFPPDGFEEKPEKEKKQTNFTLCSVCNIQLNSTAQAQIHYNGKSHQKRLKQLSTGLVKNDTGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLRALEATKTKQKPVTAKDSAKTTFTSITTNTINASSDKTDSTTGTPAISTTTVEIRKSSVMTTEITSKVEKSPTTASGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGAIKAFPRAGVKGKGPANKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLAPRLLPGPLAAAAAAVAVSSPFGLRAAPPALLPALPPALLRPAPGPMRSAHAPVLFAPY", "length": 490, "header": "tr|A0AAA9SEM3-1|A0AAA9SEM3_BOVIN Isoform 1 of Zinc finger protein 385D OS=Bos taurus OX=9913 GN=ZNF385D PE=4 SV=1 CANONICAL=A0AAA9SEM3-1" }, "locus": { "chromosome": "27", "start_pos": 44433976, "end_pos": 43450414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103323.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103323.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082061.1" } ] } }, { "isoform_ac": "A0AAA9SFP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3/entry#A0AAA9SFP3-1", "sequence": { "sequence": "MRVPGWPREQETYFHPTLAELICAFLMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLRALEATKTKQKPVTAKDSAKTTFTSITTNTINASSDKTDSTTGTPAISTTTVEIRKSSVMTTEITSKVEKSPTTASGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGAIKAFPRAGVKGKGPANKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLAPRLLPGPLAAAAAAVAVSSPFGLRAAPPALLPALPPALLRPAPGPMRSAHAPVLFAPY", "length": 360, "header": "tr|A0AAA9SFP3-1|A0AAA9SFP3_BOVIN Computationally mapped isoform of Zinc finger protein 385D OS=Bos taurus OX=9913 GN=ZNF385D PE=4 SV=1 CANONICAL=A0AAA9SEM3-1" }, "locus": { "chromosome": "27", "start_pos": 44433976, "end_pos": 44175990, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098428.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098428.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081284.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081284.1" } ] } }, { "isoform_ac": "A0AAA9T0R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3/entry#A0AAA9T0R8-1", "sequence": { "sequence": "RRSMYLGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLRALEATKTKQKPVTAKDSAKTTFTSITTNTINASSDKTDSTTGTPAISTTTVEIRKSSVMTTEITSKVEKSPTTASGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGAIKAFPRAGVKGKGPANKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLAPRLLPGPLAAAAAAVAVSSPFGLRAAPPALLPALPPALLRPAPGPMRSAHAPVLFAPY", "length": 388, "header": "tr|A0AAA9T0R8-1|A0AAA9T0R8_BOVIN Computationally mapped isoform of Zinc finger protein 385D OS=Bos taurus OX=9913 GN=ZNF385D PE=4 SV=1 CANONICAL=A0AAA9SEM3-1" }, "locus": { "chromosome": "27", "start_pos": 44433976, "end_pos": 44086657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118818.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118818.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090140.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UHY8-1", "protein_name": "Zinc finger protein 385D", "gene_name": "ZNF385D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGALGRGAACWRMRSGRKEKAPGGKPRQLHENMKKPWSPDLPASNHSYNLAFTSIPDKDGEKELAADSTEEKREREKKQTNFTLCNVCNIQLNSAAQAQIHYNGKSHQKRLKQLSNGNLKSDNGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLKALEAMKNKQKSVTTKDSAKTTFTSITTNTINTSSDKPDVTTGTPAISTTTTVEIRKSSVMTTEITSKVEKIPTTATSSTTCPSVETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGTIKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKGTHPLGVKLVFSKEPSKPMAPRILPNPLAAAAAAAAVAVNSPFSLRTAPAATLFQTSALPPALLRPAPGPIRTTHTPVLFAPY", "length": 512 }, "evidence": [ { "id": "A0AAA9SEM3", "url": "https://omabrowser.org/oma/group/A0AAA9SEM3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1UPG4-1", "protein_name": "Zinc finger protein 385D", "gene_name": "ZNF385D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNIMYFGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLKALEAMKNKQKSVTAKDSAKTTFTSITTNTINTSSDKTDTTTGTPAISTTTTVEIRKSSVMTTEITSKVEKSPTTATGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGTIKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLAPRILPNPLAAAAAAAAVAVNSPFSLRTAPAATLFQASALPPALLRPAPGPIRTAHTPVLFAPY", "length": 395 }, "evidence": [ { "id": "A0AAA9SEM3", "url": "https://omabrowser.org/oma/group/A0AAA9SEM3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AXX3-1", "protein_name": "Zinc finger protein 385D", "gene_name": "Znf385d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRKIMYFGGTCQSPALPALIHPPAPPLQPSLDIKPFLPFPLDTAATVNLFPNFNAMDPIQKAVINHTFGFPLPHRKKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLKALESMKNKQKSVTAKDSAKTTFTSITTNPITTSSDKTESTAGTQVIARSADMRKSSEVTTELTSNAEKSLTAAVAAGNNSSPPTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGTIKAFPRAGMKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRASGKPPKPKYSPYNKLQKAAHPLGVKLVFSKEPSKPLTPRILPNPLAAAAAAAAVAVNSPFSLRTAPAATLFQTSALPPALLRPAPGPIRTTHTPVLFSPY", "length": 395 }, "evidence": [ { "id": "A0AAA9SEM3", "url": "https://omabrowser.org/oma/group/A0AAA9SEM3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H6B1-1", "protein_name": "Zinc finger protein 385D", "gene_name": "ZNF385D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRNIMYFGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGTKHAKKLKALEAMKNKQKSVTAKDSAKTTFTSITTNTINTSSDKTDGTAGTPAISTTTTVEIRKSSVMTTEITSKVEKSPTTATGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQLEAHNSGTKHKTMLEARNGSGTIKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHVNSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKTAHPLGVKLVFSKEPSKPLAPRILPNPLAAAAAAAAVAVSSPFSLRTAPAATLFQTSALPPALLRPAPGPIRTAHTPVLFAPY", "length": 395 }, "evidence": [ { "id": "A0AAA9SEM3", "url": "https://omabrowser.org/oma/group/A0AAA9SEM3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM3" }, { "id": "PS00028", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 205, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 241, "end_pos": 243 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 66, "end_pos": 68 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF51-1", "uniprot_ac": "A0AAA9SF51", "uniprot_id": "A0AAA9SF51_BOVIN", "mass": { "chemical_mass": 164319.0, "monoisotopic_mass": 164319.0 }, "refseq": { "ac": "XP_024852419", "name": "pleckstrin homology domain-containing family G member 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852419" }, "gene_names": [ { "name": "PLEKHG1", "type": "recommended", "evidence": [ { "id": "A0AAA9SF51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" } ] }, { "name": "PLEKHG1", "type": "synonym", "evidence": [ { "id": "XP_024852419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852419" } ] } ], "protein_names": [ { "name": "Pleckstrin homology and RhoGEF domain containing G1", "type": "synonym", "evidence": [ { "id": "A0AAA9SF51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#names_and_taxonomy" } ] }, { "name": "pleckstrin homology domain-containing family G member 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024852419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852419" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51", "locus": { "chromosome": "9", "start_pos": 87966379, "end_pos": 87717553, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009679", "url": "https://www.ensembl.org/id/ENSBTAG00000009679" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009679", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009679", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13243", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13243", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525772", "url": "https://www.ncbi.nlm.nih.gov/gene/525772", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043324", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525772", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525772", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WHSTYSN", "url": "https://omabrowser.org/oma/group/WHSTYSN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NBN2", "url": "https://www.orthodb.org/?gene=A0A3Q1NBN2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45924", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45924", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45924:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45924:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024852419", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852419", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M261", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M261", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M261-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M261-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBN2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0U7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0U7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLK6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLK6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRP8", "url": "https://www.uniprot.org/uniprotkb/F1MRP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRP8-1", "url": "https://www.uniprot.org/uniprotkb/F1MRP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSTTMVGALVRGWRNRSSPRRAESKLIIPQSQDEIQTRVLLGAESDDKVSSPQDIEDLPGEVSDAHQLRREVRSAVTQARYLRTTARHSCSGDLGAMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1477, "header": "tr|A0AAA9SF51-1|A0AAA9SF51_BOVIN Isoform 1 of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=1 CANONICAL=A0AAA9SF51-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M261-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#A0A3Q1M261-1", "sequence": { "sequence": "MLSTTMVGALVRGWRNRSSPRRAESKLIIPQSQDEIQTRDAHQLRREVRSAVTQARYLRTTARHSCSGDLGAMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1452, "header": "tr|A0A3Q1M261-1|A0AAA9SF51_BOVIN Computationally mapped isoform of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=1 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87816113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081639.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081639.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067477.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067477.2" } ] } }, { "isoform_ac": "A0A3Q1NBN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#A0A3Q1NBN2-1", "sequence": { "sequence": "MDAHQLRREVRSAVTQARYLRTTARHSCSGDLGAMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1414, "header": "tr|A0A3Q1NBN2-1|A0AAA9SF51_BOVIN Computationally mapped isoform of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=2 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87859607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070188.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070188.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068748.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068748.2" } ] } }, { "isoform_ac": "A0AAA9SF51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#A0AAA9SF51-1", "sequence": { "sequence": "MLSTTMVGALVRGWRNRSSPRRAESKLIIPQSQDEIQTRVLLGAESDDKVSSPQDIEDLPGEVSDAHQLRREVRSAVTQARYLRTTARHSCSGDLGAMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1477, "header": "tr|A0AAA9SF51-1|A0AAA9SF51_BOVIN Isoform 1 of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=1 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87816113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110796.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110796.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081069.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081069.1" } ] } }, { "isoform_ac": "A0AAA9T5F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#A0AAA9T5F3-1", "sequence": { "sequence": "MLSTTMVGALVRGWRNRSSPRRAESKLIIPQSQDEIQTRDAHQLRREVRSAVTQARYLRTTARHSCSGDLGAMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1420, "header": "tr|A0AAA9T5F3-1|A0AAA9T5F3_BOVIN Computationally mapped isoform of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=1 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87816113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114290.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114290.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091958.1" } ] } }, { "isoform_ac": "A0AAA9U0U7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#A0AAA9U0U7-1", "sequence": { "sequence": "MIKSAHHKILRTCRGKFQDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1262, "header": "tr|A0AAA9U0U7-1|A0AAA9U0U7_BOVIN Computationally mapped isoform of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=1 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87820678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094633.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094633.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103601.1" } ] } }, { "isoform_ac": "A0ABI0NLK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#A0ABI0NLK6-1", "sequence": { "sequence": "MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1380, "header": "tr|A0ABI0NLK6-1|A0ABI0NLK6_BOVIN Computationally mapped isoform of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=1 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87859872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140606.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140606.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106054.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106054.1" } ] } }, { "isoform_ac": "F1MRP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51/entry#F1MRP8-1", "sequence": { "sequence": "MCLGNRCSTPLVLPAGAAEPNRLDAHQLRREVRSAVTQARYLRTTARHSCSGDLGAMELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSSSHLGLFPQDKEAGAIKLELMPARPFSSSELQTDRAAGQQSTDEGGERQPRAQRRVEANGPTKTGAESATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTDERSALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRLQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHYPGFCYSPEGETCGSRNGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLTSAGPSPAQRNSQPSSSTILSVLRGGGAVRNIWTDHQIRQALFPSRRSQENEEDEDDYQMFLPSFSSSDLNSAQLCEDGTSSRPCSWHMGQIESSETSSSGHRIVRRASSAGESNTCPPDIRTRDSGGSQYSSRRELQGDPKTEGQDGTTPYGSSIELTIDDIDHVYDNISYEDLKLMVAKREDAEVSPQKPVRDSVRPKSTPELAFSKKPAGPEEESTLHPRRDGALPAGEAWNQSMHDLQVMEENVYDTIALPEAPSRDFKGSSPKRSARSTFLGLEADLGCCDSLRASASQDSLQFSEDEAPYPPGSSDNDYLSLLYNSFGCNLALADRSISDKLSEEVDEIWNDLENYIKKNEVKARNRLLAAFPVSKDDVQERPLAGSTPELSARSPLSLAAGRALLAPPADRPGPAPCALDRDPASKDSSCLSLHRLSLASDLPPAESPYDVAGGSLSSADLENPEPGLDNVDKTRSRVFLMARQYSQKIKKANQLLKVKNPELEQTLSSQPQKPASKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPFKTQKDGWASPQDPSNLSSASPSHAQQGSEDWLLHSTYSNGELADFCPWPEQDLKSKYPILEINARSTPKQLSAACSVPSLQTSDPLLGFVQRHSVVVSQPNKENSCQGHLYNSLGRKGISAKSQPYNRSQSSSSILINKSADSINYPSGVAKQQPVSLHRSSRWESHQDLLPSIADSGQQGPEKRSDLTLQDSQKVLVVNRNLPLSAQMATQNYFSNFKETEGDEDDYVEIKSEEDESELELSHSRRRKSDPKITDADFADNVCSHTTSYSLNSPCTPKKPVSGKLGISPYLTPYNDPDKLNDYLWKGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1436, "header": "tr|F1MRP8-1|A0AAA9SF51_BOVIN Computationally mapped isoform of Pleckstrin homology and RhoGEF domain containing G1 OS=Bos taurus OX=9913 GN=PLEKHG1 PE=4 SV=3 CANONICAL=A0AAA9SF51-1" }, "locus": { "chromosome": "9", "start_pos": 87963879, "end_pos": 87848215, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012769.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012769.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012769.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012769.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525772", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525772", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MZG9-1", "protein_name": "Pleckstrin homology domain-containing family G member 1 isoform X3", "gene_name": "Plekhg1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPAQPFSSSELQRDNPSGTQDMDGVRERQPGTPWRVDTNGTPQTTADSDSSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLACIRDQAKLPLGTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAIRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLLDKVLLITKKRDDTFTYKSHILCGNLMLVEVIPKDPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGQTKAPFGASKEGAAPYRMRRKSEPSSRSHKVMKTSETAHDIQKVSREEGSSPLTSATPSPAQRNSQPTSTAIISMLRGGGAVRSLWTDHHLRQSLFPSRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENTSSRPCSWHLGLIEPAEISSSGHRIVRRASSAGESNTCPPEVRIRDSDGSQYCPRREMQNGPQPEGQGAMTPFGSSVELTIDDIDHVYDNISFEDLKLMVAKRDEAESSFSKSPRDSVRPKSTPELAFSKRQASHSTSSLYPKKEAAPSGQEASSQSIHELQVVEENIYDTIGLPDPPSLDFKCSTLKQPKKNSFLGLEADFACCDSLRPFVSQDSLQFSEDDVSYPQGPSDTDYLSLLYDSPRCNLPIADKTLSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPERLCVESSRELSRDTGHATSMLSLPGNQAFLTPGKSRVARASRANCSLGDDLISTEGSFMSLNQLSLASEVPPMDSPYDLANYSLPQADPENPDLGLEATDKTKSRVFMMARQYSQKIKKANQILKVRSPELEQPPSSQHKPIPKDLAAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPIKVQKDGWARTQEPSLHRPMSPSQPHRGGEDWLWHSPYSNGELADFCPQSEQDSKAKYPTLEIITKSIPRQLSAACSVPSLQVSDPLLGPVQRCSVVVSQPHKENCQGHLYNSLGRKAQPSSRPQSSSSILINKSLDSINYPSETENKHLLSLHKSPRGVSQQDLLTGVVDSCQQDTGKRSDLTLQDSQKVLVVNRNLPLSAQVATQNYFSNFKETEGDEDDYVEIKSEEEEVDLGLSLSQGRKSDPKTPAPDCSGNLCRHSAPCSLKEPVSSRLGLPPYLTPCKDSDKLNDYLWRGPSPSQQNIVQSLREKFQCLSSSSFA", "length": 1379 }, "evidence": [ { "id": "A0AAA9SF51", "url": "https://omabrowser.org/oma/group/A0AAA9SF51/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XPU3-1", "protein_name": "Pleckstrin homology and RhoGEF domain containing G1", "gene_name": "PLEKHG1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDLSDSDRPVSFSSTSSSASSRDSHCSFGSRMTLVSNSHLGLFNQEKEAGAIKLELVPARRFSSNKPRKNIPTEQEDPEESLEKKLSTPRKAEPKGAGKNCAMSLVTEPTSPKLLYVDRVVQEILETERMYVQDLKSIVKDYLDCITDQSKLPLGTEERSALFGNIRDIYLFNSELLQDLENCENDPVAIADCFVSKSEDFHIYTQYCTNYPRSVAVLTECMRNKTLAKFFRERQEALQHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAIRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDEMFAYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKMQHTVQAKSQQEKRLWILHLKRLILENHPAKIPAKAKQAILEMDAIHHPGFHYSPEGETKSTYQPKEGATQQRVRRKSEPSSRVHKVLKSNDISPDMQKRICIEGALLSQANKLGSNESLLNSRKKGSLESSGLESQFQGSAEPAYNSDQDENLQTSAAEQIDADDEEESEQGMQQNSLQKSKGGRKRLNSQAAENVEKRRSVNLSKCEMQSSKDPSDEESSQLNTDLPFSCSARQSQSPRQFNTPQNNSLIMNILGGTTSVRNIWTDHQIRQALFPSRRPPYENEDDDDDYQMFMPSLSTSNSGSAVSGERRSHSDRPCSWHLGVVHQNETPSSNRHKIVRRASSAGESNTCPTIARCKISERSSRRDVKRTDVSSMNAYPESSEELTIDDIEHVYDNISYEDLKLMGLTRREETHHGPQRSARDSLYEEENKSSLNSPSKKRTANQSRTSLHASRDEILLGRDAATSSLDELRIVEDNVYDTIVLPETPLLKFKHDPLKCSKKRSFLGLEKDLTCSDNLQQFVSEESLQFSEDESPYHRLPIDNDYLSLVDSSSNSDSLSHKSAADKLSEEVDEIWNDLENYIKKNQEKTRDRHLAAFPVCKDDIQERLHAGSTPELSKDVEYSMSTLSLPETPIFPKTVKPRAATVSEASLRLEDATACKESSLASLNRSSFLGEMPFVDSPYESASSVLSNAHTECMENDPAIVDKTKNRVFMMARQYSQKIKKANQLLKVKTPEQEQPASRQQKLKHKDLAAILEEKKQGGPAIGARIAEYSQLYDQIVFRDSSPKVQKEAWASPQEPSAVRFSTPLASTLPCAQVTGECSRAEDWLLHSTYSNGELADFSPWPESQDTKSKSSYAEAVTKSNSRQLPSACSVPSLQISNRLHVPAQRWSAIISQPNKENLHQDHIYNSLGRRVSSMKPQAYSRSQSSSSIVVNRSGESIVYPNETDKKTPHSNRNFRLNSHQALGIASACTGPDMRKQIPENYSDMILQDSQKVLRVNRPSPLTAQMATQNYFSNFKDTEEGEGDDDDYVEIRSEDEGSDLEASQNQTRKLDPKLHNTDTDPSETLCSKTVSCTPAKPTGSKHTLTPYLTAYSDSDKLNDYLWRVPSPSQQNIVQSLREKFQCLSSSSFA", "length": 1530 }, "evidence": [ { "id": "A0AAA9SF51", "url": "https://omabrowser.org/oma/group/A0AAA9SF51/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LJM1-1", "protein_name": "Pleckstrin homology and RhoGEF domain containing G1", "gene_name": "Plekhg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSTTMVGTLVRGWRNRSSPRRTELKPPTPQRQGGIRIQDGHRRLQLEVPSAVSRVPDPRTTTEPSQCPERKTMELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPAQPFSSSELQKDNPAGPPNMDGVGEKQPRAPWRVDTNGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLACIRDQTKLPLGTEDRAALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLLDKLLLITKKREDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKSPKLQHTVQAKSQQEKRLWILHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYDPKGEVKTPCGSAPHRLRRKSEPSSRSHKVLKTSETAQDIQKVSREESSSQLTSAVPAQRNRQPGNAAVLNMLRGGGSVRGLWMDHHIQQPFFPSRRTPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENTSSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRLRDSDGSQYCPGREMQNSPQPGGQGGMTPFGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETESSFSKSSRDSVRPKSTPELAFSKRQASHSTSSLHSKKETASSGQEASNQSIHEHQEVEENIYDTIGLPDPPSLNFQRSSLQQPKRSTFLGLEADFACCDSLRPFVSQDRLQFSEDDISYHQGPSDTDYLSLLYDSPRCNLPIADKTLSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDVPERLYVESTQELSRDAGRATSMLALPGSQTFLTPGESRVVRASRANCSLEDDLISTEGSFLSLNQLSLVSDEPSEDNPYDLASCSLPQTDPENPDPRMEITDKTKSRVFMMARQYSQKIKKVNQLLKVKSPELEQPLSSQHRPIHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKSQKDGWTSTQEPALHRPASPPQVQGAGEDWLWHSSYSNREVADFSPQTEQDSKSKYPVTLESITKIMPRQLSAACSVPSLQGSDPLLGSVQQRCSVVVSQPHKENSGQGHLYNSLGRKAISAKLQPYSRPQSSSSVLINKSLDSINYPSETEKKQLLSLQKSPRGASQQDLLSGLADSCQQDTGKQSDLTLQDSQKVLVVNRNLPLSAQIASQNYFSNFKETEGDEDDYVEIKSEEDEVRLDLSPRRNRKSDPKIPDPDCSDNICRHNTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1453 }, "evidence": [ { "id": "A0AAA9SF51", "url": "https://omabrowser.org/oma/group/A0AAA9SF51/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ULL1-1", "protein_name": "Pleckstrin homology domain-containing family G member 1", "gene_name": "PLEKHG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNTLHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1385 }, "evidence": [ { "id": "A0AAA9SF51", "url": "https://omabrowser.org/oma/group/A0AAA9SF51/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1159, "end_pos": 1161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1271, "end_pos": 1273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1282, "end_pos": 1284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 762, "end_pos": 764, "annotation": "n_glycosylation_sequon" }, { "start_pos": 828, "end_pos": 830, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SF51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 389, "start_aa": "Tyr", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SF51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF51" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 413, "end_pos": 512, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1159, "end_pos": 1161 }, { "start_pos": 1271, "end_pos": 1273 }, { "start_pos": 1282, "end_pos": 1284 }, { "start_pos": 16, "end_pos": 18 }, { "start_pos": 551, "end_pos": 553 }, { "start_pos": 762, "end_pos": 764 }, { "start_pos": 828, "end_pos": 830 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHH4-1", "uniprot_ac": "A0AAA9SHH4", "uniprot_id": "A0AAA9SHH4_BOVIN", "mass": { "chemical_mass": 60175.0, "monoisotopic_mass": 60175.0 }, "refseq": {}, "gene_names": [ { "name": "TBC1D22B", "type": "recommended", "evidence": [ { "id": "A0AAA9SHH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 22B", "type": "synonym", "evidence": [ { "id": "A0AAA9SHH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May act as a GTPase-activating protein for Rab family protein(s).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU3#function" }, { "database": "UniProtKB", "id": "ARBA00043879", "url": "https://www.uniprot.org/uniprotkb/ARBA00043879#function" }, { "database": "UniProtKB", "id": "A0AAA9SHH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4#function" }, { "database": "UniProtKB", "id": "A0AAA9SSE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE9#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3Z2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D22B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4", "locus": { "chromosome": "23", "start_pos": 11222150, "end_pos": 11148434, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014253", "url": "https://www.ensembl.org/id/ENSBTAG00000014253" } ] } } ], "crossref": [ { "id": "A0AAA9SHH4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014253", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014253", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615878", "url": "https://www.ncbi.nlm.nih.gov/gene/615878", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3Z2", "url": "https://www.orthodb.org/?gene=A0A3Q1M3Z2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957:SF462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957:SF462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M3Z2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLM0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLM0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGCGSRPGSGGVGPLRGFPQPGGGRSSCIGDSGVSIQPVYGAQHPPLDPRLTKNFIKERSKVSTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPAFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPASYKVIKSSSDAQLSRNSSDSCLRNPLHKQQSLPLRPVIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR", "length": 522, "header": "tr|A0AAA9SHH4-1|A0AAA9SHH4_BOVIN Isoform 1 of TBC1 domain family member 22B OS=Bos taurus OX=9913 GN=TBC1D22B PE=4 SV=1 CANONICAL=A0AAA9SHH4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4/entry#A0A3Q1M3Z2-1", "sequence": { "sequence": "MISLASSKDLSYPSGLFSSACIQPVYGAQHPPLDPRLTKNFIKERSKVSTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPAFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPASYKVIKSSSDAQLSRNSSDSCLRNPLHKQQSLPLRPVIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR", "length": 507, "header": "tr|A0A3Q1M3Z2-1|A0AAA9SHH4_BOVIN Computationally mapped isoform of TBC1 domain family member 22B OS=Bos taurus OX=9913 GN=TBC1D22B PE=4 SV=2 CANONICAL=A0AAA9SHH4-1" }, "locus": { "chromosome": "23", "start_pos": 11221146, "end_pos": 11149465, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079920.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079920.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068272.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068272.2" } ] } }, { "isoform_ac": "A0AAA9SAU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4/entry#A0AAA9SAU3-1", "sequence": { "sequence": "MEHSTLLWTLGSPKTLSDTSACLVLTADALSFIKERSKVSTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPAFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPASYKVIKSSSDAQLSRNSSDSCLRNPLHKQQSLPLRPVIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR", "length": 498, "header": "tr|A0AAA9SAU3-1|A0AAA9SHH4_BOVIN Computationally mapped isoform of TBC1 domain family member 22B OS=Bos taurus OX=9913 GN=TBC1D22B PE=4 SV=1 CANONICAL=A0AAA9SHH4-1" }, "locus": { "chromosome": "23", "start_pos": 11221146, "end_pos": 11164092, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111276.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111276.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082460.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082460.1" } ] } }, { "isoform_ac": "A0AAA9SHH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4/entry#A0AAA9SHH4-1", "sequence": { "sequence": "MVGCGSRPGSGGVGPLRGFPQPGGGRSSCIGDSGVSIQPVYGAQHPPLDPRLTKNFIKERSKVSTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPAFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPASYKVIKSSSDAQLSRNSSDSCLRNPLHKQQSLPLRPVIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR", "length": 522, "header": "tr|A0AAA9SHH4-1|A0AAA9SHH4_BOVIN Isoform 1 of TBC1 domain family member 22B OS=Bos taurus OX=9913 GN=TBC1D22B PE=4 SV=1 CANONICAL=A0AAA9SHH4-1" }, "locus": { "chromosome": "23", "start_pos": 11221146, "end_pos": 11149030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131763.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131763.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084797.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084797.1" } ] } }, { "isoform_ac": "A0AAA9SSE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4/entry#A0AAA9SSE9-1", "sequence": { "sequence": "MAAENSKQFWKRSAKLPGSFIKERSKVSTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPAFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPASYKVIKSSSDAQLSRNSSDSCLRNPLHKQQSLPLRPVIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR", "length": 486, "header": "tr|A0AAA9SSE9-1|A0AAA9SSE9_BOVIN Computationally mapped isoform of TBC1 domain family member 22B OS=Bos taurus OX=9913 GN=TBC1D22B PE=4 SV=1 CANONICAL=A0AAA9SHH4-1" }, "locus": { "chromosome": "23", "start_pos": 11221146, "end_pos": 11148771, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117874.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117874.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088256.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088256.1" } ] } }, { "isoform_ac": "A0AAF6DLM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4/entry#A0AAF6DLM0-1", "sequence": { "sequence": "MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVSTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPAFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPASYKVIKSSSDAQLSRNSSDSCLRNPLHKQQSLPLRPVIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSHNTDLDELRKCSWPGVPREVRPVTWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR", "length": 473, "header": "tr|A0AAF6DLM0-1|A0AAF6DLM0_BOVIN Computationally mapped isoform of TBC1 domain family member 22B OS=Bos taurus OX=9913 GN=TBC1D22B PE=4 SV=1 CANONICAL=A0AAA9SHH4-1" }, "locus": { "chromosome": "23", "start_pos": 11221146, "end_pos": 11148771, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018938.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018938.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018938.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018938.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4" } ], "pmid": "" }, { "name": "14-3-3 protein binding", "id": "GO:0071889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071889", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH4" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 227, "end_pos": 451, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIA3-1", "uniprot_ac": "A0AAA9SIA3", "uniprot_id": "A0AAA9SIA3_BOVIN", "mass": { "chemical_mass": 57320.0, "monoisotopic_mass": 57320.0 }, "refseq": { "ac": "NP_001179123", "name": "xaa-Pro aminopeptidase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179123" }, "gene_names": [ { "name": "XPNPEP3", "type": "recommended", "evidence": [ { "id": "A0AAA9SIA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ] }, { "name": "XPNPEP3", "type": "synonym", "evidence": [ { "id": "NP_001179123", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179123" } ] } ], "protein_names": [ { "name": "Xaa-Pro aminopeptidase 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SIA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3/entry#names_and_taxonomy" } ] }, { "name": "3.4.11.9", "type": "synonym", "evidence": [ { "id": "A0AAA9SIA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3/entry#names_and_taxonomy" } ] }, { "name": "Aminopeptidase P3", "type": "synonym", "evidence": [ { "id": "A0AAA9SIA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3/entry#names_and_taxonomy" } ] }, { "name": "xaa-Pro aminopeptidase 3", "type": "synonym", "evidence": [ { "id": "NP_001179123", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179123" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XPNPEP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3", "locus": { "chromosome": "5", "start_pos": 112157619, "end_pos": 112115757, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006204", "url": "https://www.ensembl.org/id/ENSBTAG00000006204" } ] } } ], "crossref": [ { "id": "A0AAA9SIA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006204", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006204", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539202", "url": "https://www.ncbi.nlm.nih.gov/gene/539202", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539202", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539202", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSYFWYL", "url": "https://omabrowser.org/oma/group/DSYFWYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBV5", "url": "https://www.orthodb.org/?gene=A0A3Q1MBV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BNA2", "url": "https://www.orthodb.org/?gene=E1BNA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43226:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43226:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05195", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05195", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179123", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBV5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBV5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNA2", "url": "https://www.uniprot.org/uniprotkb/E1BNA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BNA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRWLFSATRLVPAVASARSLSGCLSCSRRRYSLQPIPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIHKEAQEQSGTDHTVVLLSNPTYYMSNDIPYIFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPAHKAMLFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLVPKLKAETHTLWYDWMRPAHKQLHCDYMQQLAEVKARSKNKVRAVQQLVQRLRLIKSPAEIERMQVAGKLTSQAFIETMFASKAPVEEGFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEVQRDCLTLCCPGTSLENVYSMMLTLISQKLKELGITRNIKEKNPFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYIPEDDQDAPERFRGLGVRIEDDVVVTEASPLVLSADCPKEMKDIEQICSRAS", "length": 507, "header": "tr|A0AAA9SIA3-1|A0AAA9SIA3_BOVIN Isoform 1 of Xaa-Pro aminopeptidase 3 OS=Bos taurus OX=9913 GN=XPNPEP3 PE=3 SV=1 CANONICAL=A0AAA9SIA3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3/entry#A0A3Q1MBV5-1", "sequence": { "sequence": "MRWLFSATRLVPAVASARSLSGCLSCSRRRYSLQPIPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIHKEAQEQSGTDHTVVLLSNPTYYMSNDIPYIFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPAHKAMLFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLVPKLKAETHTLWYDWMRPAHKQLHCDYMQQLAEVKARSKNKVRAVQQLVQRLRLIKSPAEIERMQVAGKLTSQFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEVQRDCLTLCCPGTSLENVYSMMLTLISQKLKELGITRNIKEKNPFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYIPEDDQDAPERFRGLGVRIEDDVVVTEASPLVLSADCPKEMKDIEQICSRAS", "length": 486, "header": "tr|A0A3Q1MBV5-1|A0AAA9SIA3_BOVIN Computationally mapped isoform of Xaa-Pro aminopeptidase 3 OS=Bos taurus OX=9913 GN=XPNPEP3 PE=3 SV=1 CANONICAL=A0AAA9SIA3-1" }, "locus": { "chromosome": "5", "start_pos": 112157280, "end_pos": 112115956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075514.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075514.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068242.1" } ] } }, { "isoform_ac": "A0AAA9SIA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3/entry#A0AAA9SIA3-1", "sequence": { "sequence": "MRWLFSATRLVPAVASARSLSGCLSCSRRRYSLQPIPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIHKEAQEQSGTDHTVVLLSNPTYYMSNDIPYIFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPAHKAMLFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLVPKLKAETHTLWYDWMRPAHKQLHCDYMQQLAEVKARSKNKVRAVQQLVQRLRLIKSPAEIERMQVAGKLTSQAFIETMFASKAPVEEGFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEVQRDCLTLCCPGTSLENVYSMMLTLISQKLKELGITRNIKEKNPFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYIPEDDQDAPERFRGLGVRIEDDVVVTEASPLVLSADCPKEMKDIEQICSRAS", "length": 507, "header": "tr|A0AAA9SIA3-1|A0AAA9SIA3_BOVIN Isoform 1 of Xaa-Pro aminopeptidase 3 OS=Bos taurus OX=9913 GN=XPNPEP3 PE=3 SV=1 CANONICAL=A0AAA9SIA3-1" }, "locus": { "chromosome": "5", "start_pos": 112157280, "end_pos": 112115956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126738.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126738.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085965.1" } ] } }, { "isoform_ac": "E1BNA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3/entry#E1BNA2-1", "sequence": { "sequence": "MRWLFSATRLVPAVASARSLSGCLSCSRRRYSLQPIPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIHKEAQEQSGTDHTVVLLSNPTYYMSNDIPYIFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPAHKAMLFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLVPKLKAETHTLWYDWMRPAHKQLHCDYMQQLAEVKARSKNKVRAVQQLVQRLRLIKSPAEIERMQVAGKLTSQAFIETMFASKAPVEEGFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEVQRDCLTLCCPGTSLENVYSMMLTLISQKLKELGITRNIKEKNPFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPVAAPLQTAWNCLHCSTLQYPDPFSWASERAGSLMVPQLE", "length": 491, "header": "tr|E1BNA2-1|E1BNA2_BOVIN Computationally mapped isoform of Xaa-Pro aminopeptidase OS=Bos taurus OX=9913 GN=XPNPEP3 PE=3 SV=2 CANONICAL=A0AAA9SIA3-1" }, "locus": { "chromosome": "5", "start_pos": 112154045, "end_pos": 112115956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008149.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008149.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008149.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008149.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 64, "start_aa": "Thr", "end_pos": 64, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr64", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539202", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539202", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B5DEQ3-1", "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "Xpnpep3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSLLSTPRLVPVIARLRGLSGCMSCLQRRYSLQPVPVKEIPNRYLGQPSPVTHPHLLRPGEVTPGLSQVEYALRRHKLMALVHKEAQGHSGTDHTVVVLSNPIHYMSNDIPYTFHQDNSFLYLCGFQEPDSILVLQSCSGKQLPSHKAMLFVPRRDPGRELWDGPRSGTDGAIALTGVDDAYPLEEFQHLLPKLRAETNMVWYDWMKPSHAQLHSDYMQPLTEAKATSKNKVRSVQHLIQHLRLIKSPAEIKRMQIAGKLTSEAFIETMFASKAPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQKACLTLCSPGTSLENIYSMMLTLMGQKLKDLGIIKTSKESAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYIPEGDTDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEVNDIEQICSRTS", "length": 506 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B7ZMP1-1", "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "Xpnpep3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSLLSTPKLAPVLARLRGLSGCMSCLQRRYSLQPAPVKKIPNRYLGQPSPVTHPHLLRPGEVTPGLSQVEYALRRHKLMALVHKEAQGHSGTDHTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSFSGKQLPSHKAMLFVPRRDPGRELWDGPRSGTDGAIALTGVDEAYPLEEFQHLLPKLRAETNMVWYDWMKPSHAQLHSDYMQPLTEAKARSKNKVRSVQQLIQRLRLVKSPSEIKRMQIAGKLTSEAFIETMFASKAPIDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRACLTLCSPGTSLENIYSMMLTLIGQKLKDLGITKTSKESAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVEPGIYIPEDDRDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSRTS", "length": 506 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1NH26-1", "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "XPNPEP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRLPAVVRGWRGLAVCKSCILRRFSIQPAQQKKIPNRYLGQPSPFTHPHLLKPGEVTPGLSQVEYSLRRHKLMALIQKEAQGWEGLDHTVILLSNPTYYMSNDIPYVFHQDTNFLYLCGFQEPDSILVLQSLPGKALPSHKAILFVPRRDPSRELWDGPRSGTDGAVALTGVDEAYTIEEFGHLVAKLKGESNKVWYDVTKPVHKELHSDYMQPLAELKARSKNHIQSIRHLVQNLRLIKSPAEIERMKIAGRVTAEAFVETMFARKSPVDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGELVLLDGGCESSCYVSDITRTWPVNGRFTKPQAELYQAVLDIQKSCLSLCSPGVSLENIYSLMLSLIGQKLKDLGILKSSITDSHFFKAVRRYCPHHVGHYLGMDVHDTPDISRSVPLQPGMVITIEPGLYIPEDDVSAPERFRGIGVRIEDDVVIADDSPLILSADCPKEIYDIEQICGRSS", "length": 502 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4HZG9-1", "protein_name": "Intermediate cleaving peptidase 55, mitochondrial", "gene_name": "ICP55", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MQFLARNLVRRVSRTQVVSRNAYSTQTVRDIGQPTPASHPHLMAEGEVTPGIRIEEYIGRRKKLVELLPENSLAIISSAPVKMMTDVVPYTFRQDADYLYLTGCQQPGGVAVLSDERGLCMFMPESTPKDIAWEGEVAGVDAASEVFKADQAYPISKLPEILSDMIRHSSKVFHNVQSASQRYTNLDDFQNSASLGKVKTLSSLTHELRLIKSPAELKLMRESASIACQGLLKTMLHSKGFPDEGILSAQVEYECRVRGAQRMAFNPVVGGGSNASVIHYSRNDQRIKDGDLVLMDMGCELHGYVSDLTRTWPPCGKFSSVQEELYDLILQTNKECIKQCKPGTTIRQLNTYSTELLCDGLMKMGILKSRRLYHQLNPTSIGHYLGMDVHDSSAVGYDRPLQPGFVITIEPGVYIPSSFDCPERFQGIGIRIEDDVLITETGYEVLTGSMPKEIKHIETLLNNHCHDNSARTSPVSLCKVKGLHTNRNPRRLF", "length": 493 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P40051-1", "protein_name": "Intermediate cleaving peptidase 55", "gene_name": "ICP55", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLHRINPVRFSMQSCQRYFSKLVSPLEQHKSNTFTNRVRIPIEAGQPLHETRPFLIKSGELTPGISALEYYERRIRLAETLPPKSCVILAGNDIQFASGAVFYPFQQENDLFYLSGWNEPNSVMILEKPTDSLSDTIFHMLVPPKDAFAEKWEGFRSGVYGVQEIFNADESASINDLSKYLPKIINRNDFIYFDMLSTSNPSSSNFKHIKSLLDGSGNSNRSLNSIANKTIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAKRFRNERTLDSFLHYKFISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSGWNVEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIPNEESFPSYFRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENVMQNGLSTKFEEDQVAPL", "length": 511 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54T46-1", "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "xpnpep3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNICKLNKFIISKSSSSLSSTSSKIKTNCLIKNAKMFSSSLNLNRFYSTNNTNNNKLKKPLSIGQATFETHPYLLDKNEITKGIKMKEFKDRREKLMKNFPIGSVVVIFTPPEPMMSYDIPWSFRQNTNFNYLTGFNEPEAVLVLVKTSELDHQSYLFVRERNEEKEKWDGARCGGENVKKYFGIDFGYNLTNRDIPILGKLLKSTTDGKLYCNTTPWNQLSNKLEPFLENIKFYTVESLLQQIRLIKSDAEIKMMLKSGEIAGTSFHETMKYTGTKSSSSSSSSSSSPLNEYQVSAYFEWCVKDKGAQRMSYPPVVAGGDNGHTLHYIQNNQLLNYCDLLLMDAGCEYWGYTSDITRTFPVSGKFTEAQSEVYQAVLDVNKKCIELCKPGETINSIHLKSVELIQAHLKRLGIINESNPNDYRLYYPHSIGHYLGMDTHDTLDFDYGVTLEPGMIITIEPGIYISKYDSNVPEKYRGISIRVEDDVVIPNLNNSPLVLTHLAPKEISEIESIMSNK", "length": 518 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9NQH7-1", "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "XPNPEP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS", "length": 507 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W5W7-1", "protein_name": "Aminopeptidase P N-terminal domain-containing protein", "gene_name": "Dmel\\CG9581", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNILRRLDRLIAPTVRRSAAISTSLWPHRWMSQSTTISPGSPSSKSTVNAAEVRGVAQILRQQKGNLGQPTSVSHPHLIQPDELVPGVELTEIKERRSQLMQNIRAYARSFGGEFNGHSSSCHMLVLGAASKKYMSGKIPYVFRQNSDFYYLTGCLEPDAVLLLTIDEAQNVQSELFMRPKDPHAELWDGPRTGPELAVPLFGVTEAHPLSQLEAVLAKRAGALKPHIWFDQKSTDLPSLAENMLRLSGNQQRPLLPAYTFLEAMRLLKSRDEMQLMRRTCDIASRSFNEVMAETRPGQSEHHLFAAIDYKCRMRNASYLAYPPVVAAGKNATVIHYVANSQLLGQQDLVLMDAGCEYGGYTSDITRTWPASGVFTEPQRTLYDMLHQLQEEIIGNVMKPGGETLDQLFETTCYKLGKYLQEIGLVGKSFSEYKELVSQGYRFCPHHVSHYLGMDVHDTPHVPRNTRIVPGMVFTVEPGIYIGQDCGDVPPEFRGIGIRIEDDLLINENGHVEVLTEACVKDPRALQELCKQQQKNPGASSAEAF", "length": 545 }, "evidence": [ { "id": "A0AAA9SIA3", "url": "https://omabrowser.org/oma/group/A0AAA9SIA3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" }, { "name": "metalloaminopeptidase activity", "id": "GO:0070006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070006", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" }, { "name": "aminopeptidase activity", "id": "GO:0004177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA3" }, { "id": "SM01011", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminopeptidase P N-terminal", "eco_id": "ECO_0000259", "start_pos": 67, "end_pos": 213, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.11.9", "ec_name": "Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.", "evidence": [ { "id": "3.4.11.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.11.9" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 64 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFB0-1", "uniprot_ac": "A0AAA9SFB0", "uniprot_id": "A0AAA9SFB0_BOVIN", "mass": { "chemical_mass": 39361.0, "monoisotopic_mass": 39361.0 }, "refseq": { "ac": "XP_005226791", "name": "leucine zipper protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226791" }, "gene_names": [ { "name": "LUZP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SFB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0" } ] }, { "name": "LUZP2", "type": "synonym", "evidence": [ { "id": "XP_005226791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226791" } ] } ], "protein_names": [ { "name": "Leucine zipper protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SFB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0/entry#names_and_taxonomy" } ] }, { "name": "leucine zipper protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005226791", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226791" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LUZP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0", "locus": { "chromosome": "29", "start_pos": 20080973, "end_pos": 20596652, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001043", "url": "https://www.ensembl.org/id/ENSBTAG00000001043" } ] } } ], "crossref": [ { "id": "A0AAA9SFB0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001043", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001043", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785165", "url": "https://www.ncbi.nlm.nih.gov/gene/785165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFP8", "url": "https://www.orthodb.org/?gene=A0A3Q1MFP8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22414:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22414:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005226791", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226791", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFP8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFSPAHYLLPLLPALVLGTRQDYEELEKQLKRVFKERSTILRQLTKTSRELDGIKTNLQNLKNDEISAKTDVQKLLEIGQKQREQMKALQEALESQLKETADKAEKQEATINFLKTEMERKSKMIRDLQNENKSLKHKLLFGNKLCGLHAEESKKIQSQLKELRYGKKDLLFKAQQLTDLEQKLAVAKNELEKAALDRESQLKAMKETVQLCLSTVFRDQHPLHLNPFRPYRTQLSVPTMITDTRTAYVSTTAKPQEITTEVNETPQIETTKEEVLLSTPECDTQILFQENTACSMKHDENLPNNDTAESSPVPQDEAVPPCTECDEEKKPEGTANREKKLL", "length": 343, "header": "tr|A0AAA9SFB0-1|A0AAA9SFB0_BOVIN Isoform 1 of Leucine zipper protein 2 OS=Bos taurus OX=9913 GN=LUZP2 PE=4 SV=1 CANONICAL=A0AAA9SFB0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0/entry#A0A3Q1MFP8-1", "sequence": { "sequence": "MLPKAHLTLHSRISGSRQDYEELEKQLKRVFKERSTILRQLTKTSRELDGIKTNLQNLKNDEISAKTDVQKLLEIGQKQREQMKALQEALESQLKETADKAEKQEATINFLKTEMERKSKMIRDLQNENKSLKHKLLFGNKLCGLHAEESKKIQSQLKELRYGKKDLLFKAQQLTDLEQKLAVAKNELEKAALDRESQLKAMKETVQLCLSTVFRDQHPLHLNPFRPYRTQLSVPTMITDTRTAYVSTTAKPQEITTEVNETPQIETTKEEVLLSTPECDTQILFQENTACSMKHDENLPNNDTAESSPVPQDEAVPPCTECDEEKKPEGTANREKKLL", "length": 339, "header": "tr|A0A3Q1MFP8-1|A0AAA9SFB0_BOVIN Computationally mapped isoform of Leucine zipper protein 2 OS=Bos taurus OX=9913 GN=LUZP2 PE=4 SV=2 CANONICAL=A0AAA9SFB0-1" }, "locus": { "chromosome": "29", "start_pos": 20426012, "end_pos": 20083941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077620.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077620.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073041.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073041.2" } ] } }, { "isoform_ac": "A0AAA9SFB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB0/entry#A0AAA9SFB0-1", "sequence": { "sequence": "MKFSPAHYLLPLLPALVLGTRQDYEELEKQLKRVFKERSTILRQLTKTSRELDGIKTNLQNLKNDEISAKTDVQKLLEIGQKQREQMKALQEALESQLKETADKAEKQEATINFLKTEMERKSKMIRDLQNENKSLKHKLLFGNKLCGLHAEESKKIQSQLKELRYGKKDLLFKAQQLTDLEQKLAVAKNELEKAALDRESQLKAMKETVQLCLSTVFRDQHPLHLNPFRPYRTQLSVPTMITDTRTAYVSTTAKPQEITTEVNETPQIETTKEEVLLSTPECDTQILFQENTACSMKHDENLPNNDTAESSPVPQDEAVPPCTECDEEKKPEGTANREKKLL", "length": 343, "header": "tr|A0AAA9SFB0-1|A0AAA9SFB0_BOVIN Isoform 1 of Leucine zipper protein 2 OS=Bos taurus OX=9913 GN=LUZP2 PE=4 SV=1 CANONICAL=A0AAA9SFB0-1" }, "locus": { "chromosome": "29", "start_pos": 20596453, "end_pos": 20083941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111978.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111978.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081138.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 306, "end_pos": 308 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG23-1", "uniprot_ac": "A0AAA9SG23", "uniprot_id": "A0AAA9SG23_BOVIN", "mass": { "chemical_mass": 16946.0, "monoisotopic_mass": 16946.0 }, "refseq": {}, "gene_names": [ { "name": "C16H1orf53", "type": "recommended", "evidence": [ { "id": "A0AAA9SG23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23" } ] } ], "protein_names": [ { "name": "Chromosome 16 C1orf53 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SG23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C16H1orf53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23", "locus": { "chromosome": "16", "start_pos": 76854158, "end_pos": 76846992, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051004", "url": "https://www.ensembl.org/id/ENSBTAG00000051004" } ] } } ], "crossref": [ { "id": "A0AAA9SG23", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG23", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21037:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21037:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAWRVPASALRRTQPAAAPPERPPRDGTAFRRRRGVPLCSVAREDGGGPGPDSRGGPEEATKRPASQELTAAERRIAELHAAACAAGQLNYVDPATGYVVFTQLAHLQRGQCCGSACRHVSTSSDRSTAAAFGASCPYGQINVKDPSKKKQFNSYFYV", "length": 159, "header": "tr|A0AAA9SG23-1|A0AAA9SG23_BOVIN Isoform 1 of Chromosome 16 C1orf53 homolog OS=Bos taurus OX=9913 GN=C16H1orf53 PE=4 SV=1 CANONICAL=A0AAA9SG23-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG23/entry#A0AAA9SG23-1", "sequence": { "sequence": "MAAWRVPASALRRTQPAAAPPERPPRDGTAFRRRRGVPLCSVAREDGGGPGPDSRGGPEEATKRPASQELTAAERRIAELHAAACAAGQLNYVDPATGYVVFTQLAHLQRGQCCGSACRHVSTSSDRSTAAAFGASCPYGQINVKDPSKKKQFNSYFYV", "length": 159, "header": "tr|A0AAA9SG23-1|A0AAA9SG23_BOVIN Isoform 1 of Chromosome 16 C1orf53 homolog OS=Bos taurus OX=9913 GN=C16H1orf53 PE=4 SV=1 CANONICAL=A0AAA9SG23-1" }, "locus": { "chromosome": "16", "start_pos": 76853832, "end_pos": 76847242, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103592.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103592.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082829.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHG0-1", "uniprot_ac": "A0AAA9SHG0", "uniprot_id": "A0AAA9SHG0_BOVIN", "mass": { "chemical_mass": 120145.0, "monoisotopic_mass": 120145.0 }, "refseq": { "ac": "XP_024844556", "name": "constitutive coactivator of PPAR-gamma-like protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844556" }, "gene_names": [ { "name": "FAM120C", "type": "recommended", "evidence": [ { "id": "A0AAA9SHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0" } ] }, { "name": "FAM120C", "type": "synonym", "evidence": [ { "id": "XP_024844556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844556" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 120 member C", "type": "synonym", "evidence": [ { "id": "A0AAA9SHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#names_and_taxonomy" } ] }, { "name": "constitutive coactivator of PPAR-gamma-like protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024844556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844556" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM120C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0", "locus": { "chromosome": "X", "start_pos": 91533730, "end_pos": 91658209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003855", "url": "https://www.ensembl.org/id/ENSBTAG00000003855" } ] } } ], "crossref": [ { "id": "A0AAA9SHG0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003855", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003855", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "104976390", "url": "https://www.ncbi.nlm.nih.gov/gene/104976390", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104976390", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104976390", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYLPMNN", "url": "https://omabrowser.org/oma/group/RYLPMNN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIJ1", "url": "https://www.orthodb.org/?gene=A0A3Q1MIJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLD9", "url": "https://www.orthodb.org/?gene=A0A3Q1MLD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3X6D5", "url": "https://www.orthodb.org/?gene=G3X6D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15976", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15976", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15976:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15976:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27242", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27242", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844556", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLD9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6D5", "url": "https://www.uniprot.org/uniprotkb/G3X6D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6D5-1", "url": "https://www.uniprot.org/uniprotkb/G3X6D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQGRSSSQVDGNSGTLIKEEKNDHLPSPSQSALSRDNSVCNNGNRYFPGKNGEKNHLQEQKLGTVTQQKEE", "length": 1094, "header": "tr|A0AAA9SHG0-1|A0AAA9SHG0_BOVIN Isoform 1 of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=1 CANONICAL=A0AAA9SHG0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#A0A3Q1MIJ1-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMLLASSTVSQPLGEPSWSLFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQGRSSSQVDGNSGTLIKEEKNDHLPSPSQSALSRDNSTSEDSGLGQQGCSMKGSRPPGHRFHP", "length": 1045, "header": "tr|A0A3Q1MIJ1-1|A0AAA9SHG0_BOVIN Computationally mapped isoform of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=2 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91533962, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072172.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072172.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074127.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074127.2" } ] } }, { "isoform_ac": "A0A3Q1MLD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#A0A3Q1MLD9-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQVCLIQRQQCV", "length": 1035, "header": "tr|A0A3Q1MLD9-1|A0AAA9SHG0_BOVIN Computationally mapped isoform of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=2 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91540101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075521.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075521.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070095.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070095.2" } ] } }, { "isoform_ac": "A0AAA9SHG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#A0AAA9SHG0-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQGRSSSQVDGNSGTLIKEEKNDHLPSPSQSALSRDNSVCNNGNRYFPGKNGEKNHLQEQKLGTVTQQKEE", "length": 1094, "header": "tr|A0AAA9SHG0-1|A0AAA9SHG0_BOVIN Isoform 1 of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=1 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91540007, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110438.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110438.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084782.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084782.1" } ] } }, { "isoform_ac": "A0AAA9SZD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#A0AAA9SZD9-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQGRSSSQVDGNSGTLIKEEKNDHLPSPSQSALSRDNSVCNNGNRYFPGKNGEKNHLQEQKLGTVTQQKEE", "length": 1024, "header": "tr|A0AAA9SZD9-1|A0AAA9SZD9_BOVIN Computationally mapped isoform of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=1 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91540007, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114993.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114993.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089460.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089460.1" } ] } }, { "isoform_ac": "A0AAA9TKZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#A0AAA9TKZ9-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQEKTEAQKNEAS", "length": 1022, "header": "tr|A0AAA9TKZ9-1|A0AAA9TKZ9_BOVIN Computationally mapped isoform of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=2 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91542327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135548.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135548.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099120.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099120.2" } ] } }, { "isoform_ac": "A0AAA9TS43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#A0AAA9TS43-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQGRSSSQVDGNSGTLIKEEKNDHLPSPSQSALSRDNSVCNNGNRYFPGKNGEKNHLQEQKLGTVTQQKEE", "length": 1051, "header": "tr|A0AAA9TS43-1|A0AAA9TS43_BOVIN Computationally mapped isoform of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=1 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91540007, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121732.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121732.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099298.1" } ] } }, { "isoform_ac": "G3X6D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0/entry#G3X6D5-1", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQHQHRQLPPTAALAPGAPRAARGSAPQQPPFPPAALGAYSGGAGPTRHHHPAHHFHHHGQAHPGLHPPPPPPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPIPRNQMGTLSAGKPMFSHHVPQKMKYPPPFPVRPNSSLLFSPHALGESHAFSEDSMLQDSPFANWAISYDSSASQFPNYLTSKASTPLGPDSSHSSSSDGDEPEGASSDRITETLQQQPGWEDPNSDRGSWVEPIDAGVSNASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAAILFRSARQYVYGVLFSLAETQRKMERLAIRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSLLPSPTFVPPMVPSLYPVSLYPRAMGPVPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGAKGHKKGNKQSSSDGVSKSLEPQQGRSSSQVDGNSGTLIKEEKNDHLPSPSQSALSRDNSTSEDSGLGQQGCSMKGSRPPGHRFHP", "length": 1087, "header": "tr|G3X6D5-1|G3X6D5_BOVIN Computationally mapped isoform of Family with sequence similarity 120 member C OS=Bos taurus OX=9913 GN=FAM120C PE=3 SV=3 CANONICAL=A0AAA9SHG0-1" }, "locus": { "chromosome": "X", "start_pos": 91658010, "end_pos": 91533962, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005030.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005030.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005030.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005030.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104976390", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104976390", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AVK7-1", "protein_name": "Family with sequence similarity 120 member C", "gene_name": "FAM120C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSSFLGFRNNRLGNPPLPRNQMGTISAGKPVFSHHVPQKMKYPPPFPVGPSSSLLFSPHALGESHAFSEDSMLQDSPFANWAVSYDSSASQFPNYLTSKSSPPLGPDSSHSSSSDGDEPNGASSDHITETLQQQPGWEDPNGDRGSWVQPIDAGVSDASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAIRRRLPIEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLYSRAMGSMPPPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGKGSKGHKKGNKQSTSDGVSKSLEPHQGRSRLQVNGNNGTLIKEEKNDHLPAPSQCALSRDSSVCNNGNRYFPVKNGEKSRLQEQKLGTVVAQQKEE", "length": 952 }, "evidence": [ { "id": "A0AAA9SHG0", "url": "https://omabrowser.org/oma/group/A0AAA9SHG0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A052-1", "protein_name": "Family with sequence similarity 120 member C", "gene_name": "Fam120c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLIRPAPAPLPQLESEYHREDEATWLPEVEGRGFTPFEEVKKSSGGEREKRSDYDLSSLLSSQPLLSLVSLTSALHPHPVCGLLPSPPTFPRPSRSRTLSPPPSPLPPAECARARLQLRAGIAAWLACAAAVSSAHGGSMGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPPAALAPGAPRIARGSAPLPPPLPPAAFGAYSGGAGPTRHHHPAHHFHHHGQAPPGLHPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPLPRNQMGPISPGKPMFSRQMPQKMKYPPPFPMGPNSSLLFSHSVGESHAFSEDAMLQDSSFANWAVSYDSNTSQFPNCLTSKTSPPLGPDSSHSSSSDGDEANGAGSEQVTEAVQQQPGWEDPSGDRGAWVQPVDAGASETNATESEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAIRRRLPIEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLYSRAMGSFPPPPQARSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRSRGSFGMQVVSVGGPGKGHGKEQAGRGSKGHKKGNKQGSSDGISKSVELHPSRARSQVNGNNGTLIVEEKSDPLPAPPQCALSRDSTVCNSSDDHCLPVKNGEKNHVQEQELEAVAQQKEE", "length": 1229 }, "evidence": [ { "id": "A0AAA9SHG0", "url": "https://omabrowser.org/oma/group/A0AAA9SHG0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9QJ40-1", "protein_name": "Constitutive coactivator of PPAR-gamma-like protein 2", "gene_name": "fam120c", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGVQGFQEYLEKRCPGAAVPVDLLKLARTAGRQPPHHHPHHHHHPHHPSSLPPPPPPARILVDADSGLQRLYGGYQTDWVCGGEWNAMLGYLAALSQACLYQGGLELVVVFNGTLGKDRWPEWARRAQGQRQTAQLIVNHVGSKATPPPRAWFLPPACLSHCVRLAMFRFRVRVVQTLEDHHQEVLSLYRDYGFQGLIAQDSEFALCNVPAYFSSHALKLSWNGKNLTTHQYLLSEAARQLGLKTQHLPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCEVVIKAVSEYVASIKDLGNLDSVAKDVFKQSQSRTEDKIERFKKAVEYFSAASKPRPLSMGPSPYLFPGFGPSPFAGPPGHVGAVQPLKAQFGPPQVSGVKVPYPGGLYGPGPATGPALLCQNPTQPLQDCNDSLVGKMGFADWSAPYDSSQGGSRQPNHHTAAPTGPSPSSSSSSDGEEQNDTSANHLADKSTRWEDPSGRSGSGSGDGHHGNGSGPSIPSLLSMPTRSHMDITTPPLPQVSAEVLRVAEHRHRRGLMYPQIYHILTKGEMKMPVCIEDECNPDLPPASLLFRSARQYAYGVLFSLAETQRRLERLAMRKRSPVDVPPVIVKEWCASKAKSALTPELVPALCFREWTCPNLRRLWLGRASEDRSRRTRAFLACMRSDCPALLNPTCVPSHLLLMCCVLRYMMQWPGGRILQRHELDAFLAQAVSNQLYEPDQLQELKVEKVDNRGVQLASLFMSGVDTALFVNDVCGQPLPWDHCCPWGFFDGKLFQSKLAKATRDRASLLDMCEGQEELVSRVEKMRQAILEGINLSRPPPPPPPLPPPAFLPPAMVPPFYPMHPLYPPRPLGSMPPPPPHHHHQHRPRAFPGIQSIPPQGGKLEIAGMVVGQWAGNKPIRGKGGFNMQVVSVGGKGRGKDLTVKGRGGKKVITNRTQTLSSSPPSSSPPKLMEDTKSVGRPAEGTGPASQQLNGSSSGSATGQALDLPPLAQPIQCALASRDNQSGDGVEVEAPCCLDDCPSDGALQKEE", "length": 1047 }, "evidence": [ { "id": "A0AAA9SHG0", "url": "https://omabrowser.org/oma/group/A0AAA9SHG0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8C3F2-1", "protein_name": "Constitutive coactivator of PPAR-gamma-like protein 2", "gene_name": "Fam120c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPPAALAPGAPRITRGSAPLPPPPLPPAAFGAYSGGAGPSRHHHPAHHFHHHGQAPPGLHPPPPPPLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPLPRNQMGPISPGKPMFSRQVPQKMKYPPPFPMGPNSSLLFSHSVGESHAFSEDAMLQDNSFANWAVSYDSNTSQFPNCLTSKTSPPLGPDSSHSSSSDGDEANGAGSEQITEAVQQQPGWEDPNGDRGAWGQPADAGVSETTVAESEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAIRRRLPMEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDQLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLASKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLYSRAMGSFPPPPQARSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRSRGSFGMQVVSVGGPGKGHGKEQAGRGSKGHKKGNKQGSSDVISKAVELHQSRARSQVNGNNGTLIVEEKSDPLPAPSQCALSRDSNECNNSDDHCLPVKNGEKNHVPEQELEAVAQQKEE", "length": 1091 }, "evidence": [ { "id": "A0AAA9SHG0", "url": "https://omabrowser.org/oma/group/A0AAA9SHG0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX05-1", "protein_name": "Constitutive coactivator of PPAR-gamma-like protein 2", "gene_name": "FAM120C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPPTAALAPGAPRAARGSVPLQPPLPPAALGAYSGGAGPTRHHHPAHHFHHHGQAQPGLHPPLPPPPPPQLPGARVLVDAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRLAEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLEDHHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQLGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLGFRNNRLGNPPLPRNQVGTISAGKPMFSHQVPQKVKYPPPFPVGPNSSLLFSSHALGESHAFSEDPMLQNSPFANWAVSYDSSASQFPNYLPSKASPPLGPDSSHSSSSDGDEPNGASSDHITEAFHHQPEWGNPNRDRGSWAQPVDTGVSEASLGDGEPHIPSLLSMSTRNHMDITIPPLPPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQYVYGVLFSLAETQRKMERLAMRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTCPNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGRILHRHELDTFLAQAVSTQLYEPDRLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQPVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMNHPPPSALLPSPTFVPPMVPSLYPVSLYSRAMGSMPLPPQGRSRGFAGLHPIPPQGGKLEIAGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGSKGHKKGNKQGSSDGVSKSLELHQGRSRSQVNGNSGALIKEEKSDHRLPAPSQCALSRDSNECNNGNRYLPMNNREKNHLQEQKLETVAQRKED", "length": 1096 }, "evidence": [ { "id": "A0AAA9SHG0", "url": "https://omabrowser.org/oma/group/A0AAA9SHG0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 571, "end_pos": 573 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGN3-1", "uniprot_ac": "A0AAA9SGN3", "uniprot_id": "A0AAA9SGN3_BOVIN", "mass": { "chemical_mass": 114147.0, "monoisotopic_mass": 114147.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112442305", "type": "recommended", "evidence": [ { "id": "A0AAA9SGN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3" } ] } ], "protein_names": [ { "name": "HYDIN/VesB/CFA65-like Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SGN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112442305", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGN3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051512", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051512", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23053", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23053", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23053:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23053:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MSC5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSC5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSRSIEESMGAVHMGLVRTLKGFQSKILPPMSPKVVAEDEVNRMLTPSEFLKEMSLTTEQRLANTRVMCRPQIIQLLDMRETTHQKFPGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLVLRNTDTIPRMVKVVEESSPYFKVISPKDISHKVAPGVPSVFRILFTPEENKDYAHMLTCVTEREKFIVPIKARGARAIIDFPDKLNFSTCPVKYSTQKILLVRNIGNKDSVFHIKTHGPFSVEPSVGTLNVGESMQLEVDFEPQTVGNHSERLIVHYDTGEKVFISLYGAAVDMNIRLDKNSLILEKTYISLANQRTVTIHNHSSIIAHFQWKIFATQEEEDQEKYRVCDDLSKKEKSETDEFLEECIIDSSLRQRLSILSRTFENQRKLVQADSMLFLNTIFTIEPLEGDVWPNSSAEITVYFNPREAKLYQQTIYCDISGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFVGSVHCYEAVLSNKGSIDALFNVIPPVSPLGACFVFSPKEGIIEPSGVQAVQISFSSAILGHFEEEFLVSVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLVPMTFKLRVPGDGVGQQSISSCEQYSDNQKPFWNKDELPVIRPKEFTITPSCGTIRSQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCIVPNLHVVNTEVDFGRCFLKYPYKKTIQLVNDDNLPGCYRVLPQVYQDVPAVLLSSPTPCGIIPPHSTVHIPLTLETQVPGEYRSTVYISTFGSQDPPMVCHLKSIGEGPVIYVHPSQVDFGNIYVLKDSLRVLKLSNQSFIPALFKARMAHKKSLWTIEPKEGMVPPESDVELTLTANLNDILTFKDTIVLDVEDSNTYRIPVQASGVGSTIVSDKPFAPELNLGAHFSLDTYYYHFKLTNKGRRAQQLFWMNEDFCPKEKLSKKKLAKEDRAKSQPQSSCPAPREPRGPVFQLHPVRMELSPGQTIDVILEGYSSTPRVRG", "length": 1016, "header": "tr|A0AAA9SGN3-1|A0AAA9SGN3_BOVIN Isoform 1 of HYDIN/VesB/CFA65-like Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442305 PE=4 SV=1 CANONICAL=A0AAA9SGN3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MSC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3/entry#A0A3Q1MSC5-1", "sequence": { "sequence": "RRRAGCLEPGKQRKLKMTSRSIEESMGAVHMGLVRTLKGFQSKILPPMSPKVVAEDEVNRMLTPSEFLKEMSLTTEQRLANTRVMCRPQIIQLLDMRETTHQKFPGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLVLRNTDTIPRMVKVVEESSPYFKVISPKDISHKVAPGVPSVFRILFTPEENKDYAHMLTCVTEREKFIVPIKARGARAIIDFPDKLNFSTCPVKYSTQKILLVRNIGNKDSVFHIKTHGPFSVEPSVGTLNVGESMQLEVDFEPQTVGNHSERLIVHYDTGEKVFISLYGAAVDMNIRLDKNSLILEKTYISLANQRTVTIHNHSSIIAHFQWKIFATQEEEDQEKYRVCDDLSKKEKSETDEFLEECIIDSSLRQRLSILSRTFENQRKLVQADSMLFLNTIFTIEPLEGDVWPNSSAEITVYFNPREAKLYQQTIYCDISGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFVGSVHCYEAVLSNKGSIDALFNVIPPVSPLGACFVFSPKEGIIEPSGVQAVQISFSSAILGHFEEEFLVSVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLVPMTFKLRVPGDGVGQQSISSCEQYSDNQKPFWNKDELPVIRPKEFTITPSCGTIRSQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCIVPNLHVVNTEVDFGRCFLKYPYKKTIQLVNDDNLPGCYRVLPQVYQDVPAVLLSSPTPCGIIPPHSTVHIPLTLETQVPGEYRSTVYISTFGSQDPPMVCHLKSIGEGPVIYVHPSQVDFGNIYVLKDSLRVLKLSNQSFIPALFKARMAHKKSLWTIEPKEGMVPPESDVELTLTANLNDILTFKDTIVLDVEDSNTYRIPVQASGVGSTIVSDKPFAPELNLGAHFR", "length": 939, "header": "tr|A0A3Q1MSC5-1|A0AAA9SGN3_BOVIN Computationally mapped isoform of HYDIN/VesB/CFA65-like Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442305 PE=4 SV=2 CANONICAL=A0AAA9SGN3-1" }, "locus": { "chromosome": "18", "start_pos": 40014588, "end_pos": 39827198, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076238.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076238.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072904.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072904.2" } ] } }, { "isoform_ac": "A0AAA9SGN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3/entry#A0AAA9SGN3-1", "sequence": { "sequence": "MTSRSIEESMGAVHMGLVRTLKGFQSKILPPMSPKVVAEDEVNRMLTPSEFLKEMSLTTEQRLANTRVMCRPQIIQLLDMRETTHQKFPGIDLDQALFQPFPSEIIFQNYTPCEVYEVPLVLRNTDTIPRMVKVVEESSPYFKVISPKDISHKVAPGVPSVFRILFTPEENKDYAHMLTCVTEREKFIVPIKARGARAIIDFPDKLNFSTCPVKYSTQKILLVRNIGNKDSVFHIKTHGPFSVEPSVGTLNVGESMQLEVDFEPQTVGNHSERLIVHYDTGEKVFISLYGAAVDMNIRLDKNSLILEKTYISLANQRTVTIHNHSSIIAHFQWKIFATQEEEDQEKYRVCDDLSKKEKSETDEFLEECIIDSSLRQRLSILSRTFENQRKLVQADSMLFLNTIFTIEPLEGDVWPNSSAEITVYFNPREAKLYQQTIYCDISGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFVGSVHCYEAVLSNKGSIDALFNVIPPVSPLGACFVFSPKEGIIEPSGVQAVQISFSSAILGHFEEEFLVSVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLVPMTFKLRVPGDGVGQQSISSCEQYSDNQKPFWNKDELPVIRPKEFTITPSCGTIRSQGFAAIRVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCIVPNLHVVNTEVDFGRCFLKYPYKKTIQLVNDDNLPGCYRVLPQVYQDVPAVLLSSPTPCGIIPPHSTVHIPLTLETQVPGEYRSTVYISTFGSQDPPMVCHLKSIGEGPVIYVHPSQVDFGNIYVLKDSLRVLKLSNQSFIPALFKARMAHKKSLWTIEPKEGMVPPESDVELTLTANLNDILTFKDTIVLDVEDSNTYRIPVQASGVGSTIVSDKPFAPELNLGAHFSLDTYYYHFKLTNKGRRAQQLFWMNEDFCPKEKLSKKKLAKEDRAKSQPQSSCPAPREPRGPVFQLHPVRMELSPGQTIDVILEGYSSTPRVRG", "length": 1016, "header": "tr|A0AAA9SGN3-1|A0AAA9SGN3_BOVIN Isoform 1 of HYDIN/VesB/CFA65-like Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442305 PE=4 SV=1 CANONICAL=A0AAA9SGN3-1" }, "locus": { "chromosome": "18", "start_pos": 40018790, "end_pos": 39856371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116445.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116445.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083033.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 831, "end_pos": 833, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN3" }, { "id": "PF22544", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22544" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HYDIN/VesB/CFA65-like Ig-like", "eco_id": "ECO_0000259", "start_pos": 198, "end_pos": 291, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 546, "end_pos": 548 }, { "start_pos": 590, "end_pos": 592 }, { "start_pos": 591, "end_pos": 593 }, { "start_pos": 831, "end_pos": 833 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF07-1", "uniprot_ac": "A0AAA9SF07", "uniprot_id": "A0AAA9SF07_BOVIN", "mass": { "chemical_mass": 35072.0, "monoisotopic_mass": 35072.0 }, "refseq": {}, "gene_names": [ { "name": "FNDC5", "type": "recommended", "evidence": [ { "id": "A0AAA9SF07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" } ] } ], "protein_names": [ { "name": "Fibronectin type III domain containing 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SF07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07", "locus": {} } ], "crossref": [ { "id": "A0AAA9SF07", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SF07", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051540", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051540", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMB3", "url": "https://www.orthodb.org/?gene=A0A3Q1MMB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N2B3", "url": "https://www.orthodb.org/?gene=A0A3Q1N2B3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14470", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14470", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14470:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14470:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MMB3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMB3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2B3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2B3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2B3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2B3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQAARGGAGRPDRAGGGPERQRERPPGAGAASACAAPGRPAGAAAMHPGPPRAALRLWLGCVCLALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKGSCGAACRAESWLPSSLRWIQPSRTCLWCDAQLCECVRCFLFCFFWKTQLKGFTPEGRGIPRLVACIFYLL", "length": 320, "header": "tr|A0AAA9SF07-1|A0AAA9SF07_BOVIN Isoform 1 of Fibronectin type III domain containing 5 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SF07-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07/entry#A0A3Q1MMB3-1", "sequence": { "sequence": "MHPGPPRAALRLWLGCVCLALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAERSATAGTKKSQVLVSSPSSAASMTSSRTTNPTTTRKKPRVRQKPAHQSTKAGGFSVAREAVGLPAGQSPGCHQAFAGSSHQGLVCGAMHNFASV", "length": 254, "header": "tr|A0A3Q1MMB3-1|A0A3Q1MMB3_BOVIN Computationally mapped isoform of Fibronectin type III domain containing 5 OS=Bos taurus OX=9913 GN=FNDC5 PE=4 SV=2 CANONICAL=A0AAA9SF07-1" }, "locus": { "chromosome": "2", "start_pos": 120810987, "end_pos": 120804038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068859.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068859.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070531.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070531.2" } ] } }, { "isoform_ac": "A0A3Q1N2B3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07/entry#A0A3Q1N2B3-1", "sequence": { "sequence": "MLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKVRARSTLGLAPW", "length": 148, "header": "tr|A0A3Q1N2B3-1|A0AAA9SF07_BOVIN Computationally mapped isoform of Fibronectin type III domain containing 5 OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SF07-1" }, "locus": { "chromosome": "2", "start_pos": 120809635, "end_pos": 120806555, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067292.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067292.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063369.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063369.2" } ] } }, { "isoform_ac": "A0AAA9SF07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07/entry#A0AAA9SF07-1", "sequence": { "sequence": "MQAARGGAGRPDRAGGGPERQRERPPGAGAASACAAPGRPAGAAAMHPGPPRAALRLWLGCVCLALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKGSCGAACRAESWLPSSLRWIQPSRTCLWCDAQLCECVRCFLFCFFWKTQLKGFTPEGRGIPRLVACIFYLL", "length": 320, "header": "tr|A0AAA9SF07-1|A0AAA9SF07_BOVIN Isoform 1 of Fibronectin type III domain containing 5 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SF07-1" }, "locus": { "chromosome": "2", "start_pos": 120811091, "end_pos": 120803903, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111578.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111578.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082419.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of brown fat cell differentiation", "id": "GO:0090336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SF07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF07" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 165, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHP8-1", "uniprot_ac": "A0AAA9SHP8", "uniprot_id": "A0AAA9SHP8_BOVIN", "mass": { "chemical_mass": 45553.0, "monoisotopic_mass": 45553.0 }, "refseq": {}, "gene_names": [ { "name": "TANGO2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8" } ] } ], "protein_names": [ { "name": "Transport and golgi organization 2 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TANGO2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8", "locus": { "chromosome": "17", "start_pos": 72967475, "end_pos": 72934812, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012421", "url": "https://www.ensembl.org/id/ENSBTAG00000012421" } ] } } ], "crossref": [ { "id": "A0AAA9SHP8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012421", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012421", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR17985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17985:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17985:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N6A7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6A7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6A7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5A9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9A6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ98", "url": "https://www.uniprot.org/uniprotkb/F1MZ98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ98-1", "url": "https://www.uniprot.org/uniprotkb/F1MZ98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q0Y7", "url": "https://www.uniprot.org/uniprotkb/F6Q0Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q0Y7-1", "url": "https://www.uniprot.org/uniprotkb/F6Q0Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAVRAAVGKDGQSKSMDWGGGEAAPKCAPCGASCRALCGAGQGRVHEGSRAAGRHLPARGGHEAPPGAWRSPGGGAPGGAARSDGVGSQWCPGSRLDAPPPGLAAQWRARGQRGWGPGRGGCGARARHPEVGGRGGGEPVTCGAKPPSGLMCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGKREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 427, "header": "tr|A0AAA9SHP8-1|A0AAA9SHP8_BOVIN Isoform 1 of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N6A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#A0A3Q1N6A7-1", "sequence": { "sequence": "MCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLRQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 201, "header": "tr|A0A3Q1N6A7-1|A0AAA9SHP8_BOVIN Computationally mapped isoform of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=2 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966795, "end_pos": 72956763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070844.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070844.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065946.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065946.2" } ] } }, { "isoform_ac": "A0AAA9S5A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#A0AAA9S5A9-1", "sequence": { "sequence": "MSSRQVTPVIYTVPGGACRNQHPAQEQKGRLPGVLGFPGGSAGKESTCSADPGRPLGWEDPPDKGKATHSSILAWRIPSPWGCKELDTTEQLSLDPTRPEPVTCGAKPPSGLMCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGKREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 388, "header": "tr|A0AAA9S5A9-1|A0AAA9SHP8_BOVIN Computationally mapped isoform of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966795, "end_pos": 72935011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129467.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129467.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077348.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077348.1" } ] } }, { "isoform_ac": "A0AAA9S9A6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#A0AAA9S9A6-1", "sequence": { "sequence": "VAGHQHAGQAGRAHQLLAAAAEPQCPGPSAEKGDVICYYGNRGKREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 178, "header": "tr|A0AAA9S9A6-1|A0AAA9SHP8_BOVIN Computationally mapped isoform of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966795, "end_pos": 72962815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114149.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114149.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079975.1" } ] } }, { "isoform_ac": "A0AAA9SHP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#A0AAA9SHP8-1", "sequence": { "sequence": "MSAVRAAVGKDGQSKSMDWGGGEAAPKCAPCGASCRALCGAGQGRVHEGSRAAGRHLPARGGHEAPPGAWRSPGGGAPGGAARSDGVGSQWCPGSRLDAPPPGLAAQWRARGQRGWGPGRGGCGARARHPEVGGRGGGEPVTCGAKPPSGLMCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGKREPVVLAPGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 427, "header": "tr|A0AAA9SHP8-1|A0AAA9SHP8_BOVIN Isoform 1 of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966795, "end_pos": 72949005, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096862.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096862.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084870.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084870.1" } ] } }, { "isoform_ac": "A0AAA9TZE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#A0AAA9TZE0-1", "sequence": { "sequence": "MCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGSCQTQPSRPRAGSTCDPSS", "length": 108, "header": "tr|A0AAA9TZE0-1|A0AAA9TZE0_BOVIN Computationally mapped isoform of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966318, "end_pos": 72956763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102979.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102979.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103678.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103678.1" } ] } }, { "isoform_ac": "F1MZ98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#F1MZ98-1", "sequence": { "sequence": "MCIIFFKFDPRPVSKNAYRLILAANRDEFYHRPARAADFWGSNNEVLSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGTYGLSNALLETPWRKLCFGKQLFLEAVERGRELPRDALVAQLLAVLSNDEAQLPDPAIEAQGREYVRPILSKYAAVCVRCPDYGTRTSTVILVDADGHVTFTERSMLGSDPTRWETTTHEFRLQS", "length": 214, "header": "tr|F1MZ98-1|A0AAA9SHP8_BOVIN Computationally mapped isoform of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=4 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966795, "end_pos": 72956763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016486.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016486.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016486.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016486.7" } ] } }, { "isoform_ac": "F6Q0Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8/entry#F6Q0Y7-1", "sequence": { "sequence": "MEEGKEGGTWLGISTRGKLAALTNYLQPRLNRNARGRGELVAQFLTSDMDSLSYLKKVSAEGHLYNGFNLIAADLSAEKGDVICYYGNRGKREPVVLAPGSCQTQPSRPRAGSTCDPSSASTRLCACAARTTAPGPARSSLWMQGSDPTRWETTTHEFRLQS", "length": 162, "header": "tr|F6Q0Y7-1|F6Q0Y7_BOVIN Computationally mapped isoform of Transport and golgi organization 2 homolog OS=Bos taurus OX=9913 GN=TANGO2 PE=4 SV=3 CANONICAL=A0AAA9SHP8-1" }, "locus": { "chromosome": "17", "start_pos": 72966795, "end_pos": 72962789, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016497.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016497.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016497.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016497.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHB3-1", "uniprot_ac": "A0AAA9SHB3", "uniprot_id": "A0AAA9SHB3_BOVIN", "mass": { "chemical_mass": 140616.0, "monoisotopic_mass": 140616.0 }, "refseq": {}, "gene_names": [ { "name": "TP53BP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ] } ], "protein_names": [ { "name": "Tumor protein p53 binding protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SHB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TP53BP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3", "locus": { "chromosome": "16", "start_pos": 27139603, "end_pos": 27275472, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012781", "url": "https://www.ensembl.org/id/ENSBTAG00000012781" } ] } } ], "crossref": [ { "id": "A0AAA9SHB3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012781", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012781", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11953", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11953", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514474", "url": "https://www.ncbi.nlm.nih.gov/gene/514474", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24131:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24131:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21801", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21801", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804759", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NE67", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NE67-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S185", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S185", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S185-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S185-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWG7", "url": "https://www.uniprot.org/uniprotkb/F1MWG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWG7-1", "url": "https://www.uniprot.org/uniprotkb/F1MWG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVHCLAQGFSTFKPVSSLITMEISGPVLIYRLQKVTQSSKLEFGRCRREGRRQPEDSSTRNSRNAVPAETDPPISILLGPGRRRSLQGPRPLQPRGWVLPGGPPPSGGLPLRSPPPHRATPTLRGASAWLRAVISPPASMRFGSKMMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRSEVRFFLRHERPPGRDVVSGPRSQDPSLKRNGVKVPGEHRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGHVPQPGASGQSRVAAVGPYIQSSTMPRIPSRPELLVKPALPDGPGATQASEGPMKVQTLPNMRSGAASQAKGSKIHLLGPDWTPPNADLFSSQASASVSKSSGNVPDQVDDGEVPLREKEKKVRPFSMFDTVDQSAAPPAFGTLRKNQSSEDILRDAQAANKNVAKVPPPVPSKPKQINLPYFGQTNQSPSDMKPDGTAPQLSAAVASMGGKPKPTVQQQRGLLAPGGPSVGPADQTLPPGSKQESPPAAAVRPFTPQPSKDALLPPFRKPQTVAASSIYSMYTQHQAPGKNFQQAVQSALTKPHPRAPHFPSVYGKPVIAAAQNQQQLPENVYSNNQGKSGSPEPETEPVSSVQETHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPAYPSKSASGTASPESPLEIQNPYLPVEPEKEVVPLVPEPASPEEAGSASTESNDAPAPSTGLEYVPEGVPDSSPNFQNSVEEPNPEAPPLLEVYLEEYPPYPPPPYPSGEPEGPGEDSVSLRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGIIYALWDYEPQNDDELPMKEGDCMTIVRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA", "length": 1274, "header": "tr|A0AAA9SHB3-1|A0AAA9SHB3_BOVIN Isoform 1 of Tumor protein p53 binding protein 2 OS=Bos taurus OX=9913 GN=TP53BP2 PE=3 SV=1 CANONICAL=A0AAA9SHB3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NE67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3/entry#A0A3Q1NE67-1", "sequence": { "sequence": "MFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRSEVRFFLRHERPPGRDVVSGPRSQDPSLKRNGVKVPGEHRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGHVPQPGASGQSRVAAVGPYIQSSTMPRIPSRPELLVKPALPDGPGATQASEGPMKVQTLPNMRSGAASQAKGSKIHLLGPDWTPPNADLFSSQASASVSKSSGNVPDQVDDGEVPLREKEKKVRPFSMFDTVDQSAAPPAFGTLRKNQSSEDILRDAQAANKNVAKVPPPVPSKPKQINLPYFGQTNQSPSDMKPDGTAPQLSAAVASMGGKPKPTVQQQRGLLAPGGPSVGPADQTLPPGSKQESPPAAAVRPFTPQPSKDALLPPFRKPQTVAASSIYSMYTQHQAPGKNFQQAVQSALTKPHPRAPHFPSVYGKPVIAAAQNQQQLPENVYSNNQGKSGSPEPETEPVSSVQETHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPAYPSKSASGTASPESPLEIQNPYLPVEPEKEVVPLVPEPASPEEAGSASTESNDAPAPSTGLEYVPEGVPDSSPNFQNSVEEPNPEAPPLLEVYLEEYPPYPPPPYPSGEPEGPGEDSVSLRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGIIYALWDYEPQNDDELPMKEGDCMTIVRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA", "length": 1126, "header": "tr|A0A3Q1NE67-1|A0AAA9SHB3_BOVIN Computationally mapped isoform of Tumor protein p53 binding protein 2 OS=Bos taurus OX=9913 GN=TP53BP2 PE=3 SV=2 CANONICAL=A0AAA9SHB3-1" }, "locus": { "chromosome": "16", "start_pos": 27180298, "end_pos": 27140607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082457.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082457.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069874.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069874.2" } ] } }, { "isoform_ac": "A0AAA9S185-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3/entry#A0AAA9S185-1", "sequence": { "sequence": "MQCQLRRTRRSPFCWDRAVAGASRDLGHSSPAAGSSQEMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRSEVRFFLRHERPPGRDVVSGPRSQDPSLKRNGVKVPGEHRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGHVPQPGASGQSRVAAVGPYIQSSTMPRIPSRPELLVKPALPDGPGATQASEGPMKVQTLPNMRSGAASQAKGSKIHLLGPDWTPPNADLFSSQASASVSKSSGNVPDQVDDGEVPLREKEKKVRPFSMFDTVDQSAAPPAFGTLRKNQSSEDILRDAQAANKNVAKVPPPVPSKPKQINLPYFGQTNQSPSDMKPDGTAPQLSAAVASMGGKPKPTVQQQRGLLAPGGPSVGPADQTLPPGSKQESPPAAAVRPFTPQPSKDALLPPFRKPQTVAASSIYSMYTQHQAPGKNFQQAVQSALTKPHPRAPHFPSVYGKPVIAAAQNQQQLPENVYSNNQGKSGSPEPETEPVSSVQETHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPAYPSKSASGTASPESPLEIQNPYLPVEPEKEVVPLVPEPASPEEAGSASTESNDAPAPSTGLEYVPEGVPDSSPNFQNSVEEPNPEAPPLLEVYLEEYPPYPPPPYPSGEPEGPGEDSVSLRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGIIYALWDYEPQNDDELPMKEGDCMTIVRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA", "length": 1164, "header": "tr|A0AAA9S185-1|A0AAA9SHB3_BOVIN Computationally mapped isoform of Tumor protein p53 binding protein 2 OS=Bos taurus OX=9913 GN=TP53BP2 PE=3 SV=1 CANONICAL=A0AAA9SHB3-1" }, "locus": { "chromosome": "16", "start_pos": 27208076, "end_pos": 27140607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103475.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103475.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079632.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079632.1" } ] } }, { "isoform_ac": "A0AAA9SHB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3/entry#A0AAA9SHB3-1", "sequence": { "sequence": "MVHCLAQGFSTFKPVSSLITMEISGPVLIYRLQKVTQSSKLEFGRCRREGRRQPEDSSTRNSRNAVPAETDPPISILLGPGRRRSLQGPRPLQPRGWVLPGGPPPSGGLPLRSPPPHRATPTLRGASAWLRAVISPPASMRFGSKMMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRSEVRFFLRHERPPGRDVVSGPRSQDPSLKRNGVKVPGEHRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGHVPQPGASGQSRVAAVGPYIQSSTMPRIPSRPELLVKPALPDGPGATQASEGPMKVQTLPNMRSGAASQAKGSKIHLLGPDWTPPNADLFSSQASASVSKSSGNVPDQVDDGEVPLREKEKKVRPFSMFDTVDQSAAPPAFGTLRKNQSSEDILRDAQAANKNVAKVPPPVPSKPKQINLPYFGQTNQSPSDMKPDGTAPQLSAAVASMGGKPKPTVQQQRGLLAPGGPSVGPADQTLPPGSKQESPPAAAVRPFTPQPSKDALLPPFRKPQTVAASSIYSMYTQHQAPGKNFQQAVQSALTKPHPRAPHFPSVYGKPVIAAAQNQQQLPENVYSNNQGKSGSPEPETEPVSSVQETHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPAYPSKSASGTASPESPLEIQNPYLPVEPEKEVVPLVPEPASPEEAGSASTESNDAPAPSTGLEYVPEGVPDSSPNFQNSVEEPNPEAPPLLEVYLEEYPPYPPPPYPSGEPEGPGEDSVSLRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGIIYALWDYEPQNDDELPMKEGDCMTIVRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA", "length": 1274, "header": "tr|A0AAA9SHB3-1|A0AAA9SHB3_BOVIN Isoform 1 of Tumor protein p53 binding protein 2 OS=Bos taurus OX=9913 GN=TP53BP2 PE=3 SV=1 CANONICAL=A0AAA9SHB3-1" }, "locus": { "chromosome": "16", "start_pos": 27274230, "end_pos": 27140607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108780.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108780.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083098.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083098.1" } ] } }, { "isoform_ac": "A0AAA9SQD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3/entry#A0AAA9SQD1-1", "sequence": { "sequence": "MSSTSQKSLSLQKPSAETWWTCAKNLVRAIATWLKCGVALELCLIVKKREMNVCCQSKNRNQQTFLSYRVMTSGIDGGAPSAEGDEERPVADNERMFDVLQRFGSQRSEVRFFLRHERPPGRDVVSGPRSQDPSLKRNGVKVPGEHRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGHVPQPGASGQSRVAAVGPYIQSSTMPRIPSRPELLVKPALPDGPGATQASEGPMKVQTLPNMRSGAASQAKGSKIHLLGPDWTPPNADLFSSQASASVSKSSGNVPDQVDDGEVPLREKEKKVRPFSMFDTVDQSAAPPAFGTLRKNQSSEDILRDAQAANKNVAKVPPPVPSKPKQINLPYFGQTNQSPSDMKPDGTAPQLSAAVASMGGKPKPTVQQQRGLLAPGGPSVGPADQTLPPGSKQESPPAAAVRPFTPQPSKDALLPPFRKPQTVAASSIYSMYTQHQAPGKNFQQAVQSALTKPHPRAPHFPSVYGKPVIAAAQNQQQLPENVYSNNQGKSGSPEPETEPVSSVQETHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPAYPSKSASGTASPESPLEIQNPYLPVEPEKEVVPLVPEPASPEEAGSASTESNDAPAPSTGLEYVPEGVPDSSPNFQNSVEEPNPEAPPLLEVYLEEYPPYPPPPYPSGEPEGPGEDSVSLRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGIIYALWDYEPQNDDELPMKEGDCMTIVRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA", "length": 1163, "header": "tr|A0AAA9SQD1-1|A0AAA9SQD1_BOVIN Computationally mapped isoform of Tumor protein p53 binding protein 2 OS=Bos taurus OX=9913 GN=TP53BP2 PE=4 SV=1 CANONICAL=A0AAA9SHB3-1" }, "locus": { "chromosome": "16", "start_pos": 27180270, "end_pos": 27140607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104113.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104113.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085146.1" } ] } }, { "isoform_ac": "F1MWG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3/entry#F1MWG7-1", "sequence": { "sequence": "MRFGSKMMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRSEVRFFLRHERPPGRDVVSGPRSQDPSLKRNGVKVPGEHRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGHVPQPGASGQSRVAAVGPYIQSSTMPRIPSRPELLVKPALPDGPGATQASEGPMKVQTLPNMRSGAASQAKGSKIHLLGPDWTPPNADLFSSQASASVSKSSGNVPDQVDDGEVPLREKEKKVRPFSMFDTVDQSAAPPAFGTLRKNQSSEDILRDAQAANKNVAKVPPPVPSKPKQINLPYFGQTNQSPSDMKPDGTAPQLSAAVASMGGSKQESPPAAAVRPFTPQPSKDALLPPFRKPQTVAASSIYSMYTQHQAPGKNFQQAVQSALTKPHPRAPHFPSVYGKPVIAAAQNQQQLPENVYSNNQGKSGSPEPETEPVSSVQETHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPAYPSKSASGTASPESPLEIQNPYLPVEPEKEVVPLVPEPASPEEAGSASTESNDAPAPSTGLEYVPEGVPDSSPNFQNSVEEPNPEAPPLLEVYLEEYPPYPPPPYPSGEPEGPGEDSVSLRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGIIYALWDYEPQNDDELPMKEGDCMTIVRREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA", "length": 1105, "header": "tr|F1MWG7-1|A0AAA9SHB3_BOVIN Computationally mapped isoform of Tumor protein p53 binding protein 2 OS=Bos taurus OX=9913 GN=TP53BP2 PE=3 SV=3 CANONICAL=A0AAA9SHB3-1" }, "locus": { "chromosome": "16", "start_pos": 27207203, "end_pos": 27140607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016985.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016985.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016985.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016985.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6804759", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804759", "resource": "Reactome", "description": "Regulation of TP53 Activity through Association with Co-factors" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway by p53 class mediator", "id": "GO:0072332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072332", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "positive regulation of execution phase of apoptosis", "id": "GO:1900119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900119", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" }, { "name": "NF-kappaB binding", "id": "GO:0051059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 623, "end_pos": 625, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" }, { "start_pos": 858, "end_pos": 860, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB3" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 1203, "end_pos": 1265, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 401, "end_pos": 403 }, { "start_pos": 623, "end_pos": 625 }, { "start_pos": 663, "end_pos": 665 }, { "start_pos": 858, "end_pos": 860 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEM9-1", "uniprot_ac": "A0AAA9SEM9", "uniprot_id": "A0AAA9SEM9_BOVIN", "mass": { "chemical_mass": 131793.0, "monoisotopic_mass": 131793.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD24", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 24", "type": "synonym", "evidence": [ { "id": "A0AAA9SEM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9", "locus": { "chromosome": "7", "start_pos": 19819934, "end_pos": 19842851, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064043", "url": "https://www.ensembl.org/id/ENSBTAG00000064043" } ] } } ], "crossref": [ { "id": "A0AAA9SEM9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24129:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24129:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RRS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S505", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S505", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S505-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S505-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGAELGVVYGTVAGSGGGQLGGQVLRTQAGGMLSQAPTQDHFPRQLRLSPTDLGSCPPCGPCPIPKPAAARGRRQSQDWGKSDERLLQAVENNDPTRVASLIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMLAHGANAMSTDGAGYNALHLAAKYGHPQCLKQLLQASCAVDTVDSSGWTALHHAAAGGCISCSEMLCSFKAHLNPRDRLGTTPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGTLAGDKLILHLLQEAAQRPSPPSEDDSGEASSQNSVSSHDKQGAPKKRKAPQPPINIPMPDDQDAYEEIVRLRQERGRLLQKIRGLEQHQERRKQELPEAEASSLHSLERQVQELQQLLAEKQEEKESLGREVESLQSRLSLLENERENTSYDVATLQDEEGELPEFPGAEVLLSKQLSPSAQELLASLQEQVAMLTRQNQELMEKVQVGKPGADGGFRGVGVQVAMLTRQNQELMEKVQVGKPGADGGFRGGGVQVAMLTRQNQELMEKVQILEHFEKDEMEADGPAEVIPLELYDALQAEFDQLRRQHAKALQALEQQEAREALAEEEAASREGKGLGTKTSRNGPVEIELNGTAAPETRVNGVKTTDEEAAGVETTEALSQSLEVVSTMAEATVTKPTDTEASETEGVGAQPLETKATGAEVTEMKTLERGGNPEPKATRAETTSMKTEEPEMKPNGVSAVEEELTGTEAMGVELMIPRALTGPILHPGAAEASEKLQTELETRIRSLEEALRQREREAAAELEAAHGKCEAAEAEAGRLRERVREAEGGRASGVRDGDTGQLRAALEQAREDLRDRDCRLRELEAASARLDEARAGRLLAEEEARGLRAELARREEARLELSRELEALREQLVAATATGEQQRAAAAELGQARDAAEARAAELSAACEEARQGLAELREASEALRQSAVPASEHHRLQEEALELRGRAACLEQEVVATGKEAARLRAELERERVGSMARLEHERIVGALQADVARLQGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALEKAKEKDKKITELSKEVFSLKEALKDQPGAPDSLEVEALRGQVKALREQLEEAAREHSAVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQGR", "length": 1214, "header": "tr|A0AAA9SEM9-1|A0AAA9SEM9_BOVIN Isoform 1 of Ankyrin repeat domain 24 OS=Bos taurus OX=9913 GN=ANKRD24 PE=4 SV=1 CANONICAL=A0AAA9SEM9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RRS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9/entry#A0AAA9RRS7-1", "sequence": { "sequence": "MLGHWPPLPQPPGGEKVSCGSAPLTSAPARPAAPAPSRSRRQPEAGARARTGAKVMSGCCRRWRTTIPRGWPPSSPARGWCPPSWTPRASPRYNALHLAAKYGHPQCLKQLLQASCAVDTVDSSGWTALHHAAAGGCISCSEMLCSFKAHLNPRDRLGTTPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGTLAGDKLILHLLQEAAQRPSPPSEDDSGEASSQNSVSSHDKQGAPKKRKAPQPPINIPMPDDQDAYEEIVRLRQERGRLLQKIRGLEQHQERRKQELPEAEASSLHSLERQVQELQQLLAEKQEEKESLGREVESLQSRLSLLENERENTSYDVATLQDEEGELPEFPGAEVLLSKQLSPSAQELLASLQEQVAMLTRQNQELMEKVQILEHFEKDEMEADGPAEVIPLELYDALQAEFDQLRRQHAKALQALEQQEAREALAEEEAASREGKGLGTKTSRNGPVEIELNGTAAPETRVNGVKTTDEEAAGVETTEALSQSLEVVSTMAEATVTKPTDTEASETEGVGAQPLETKATGAEVTEMKTLERGGNPEPKATRAETTSMKTEEPEMKPNGVSAVEEELTGTEAMGVELMIPRALTGPILHPGAAEASEKLQTELETRIRSLEEALRQREREAAAELEAAHGKCEAAEAEAGRLRERVREAEGGRASGVRDGDTGQLRAALEQAREDLRDRDCRLRELEAASARLDEARAGRLLAEEEARGLRAELARREEARLELSRELEALREQLVAATATGEQQRAAAAELGQARDAAEARAAELSAACEEARQGLAELREASEALRQSAVPASEHHRLQEEALELRGRAACLEQEVVATGKEAARLRAELERERVGSMARLEHERIVGALQADVARLQGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALEKAKEKDKKITELSKEVFSLKEALKDQPGAPDSLEVEALRGQVKALREQLEEAAREHSAVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQGR", "length": 1092, "header": "tr|A0AAA9RRS7-1|A0AAA9SEM9_BOVIN Computationally mapped isoform of Ankyrin repeat domain 24 OS=Bos taurus OX=9913 GN=ANKRD24 PE=4 SV=1 CANONICAL=A0AAA9SEM9-1" }, "locus": { "chromosome": "7", "start_pos": 19842652, "end_pos": 19820938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093282.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093282.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074927.1" } ] } }, { "isoform_ac": "A0AAA9S505-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9/entry#A0AAA9S505-1", "sequence": { "sequence": "MKQLCLCAAASFASQDWGKSDERLLQAVENNDPTRVASLIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMLAHGANAMSTDGAGYNALHLAAKYGHPQCLKQLLQASCAVDTVDSSGWTALHHAAAGGCISCSEMLCSFKAHLNPRDRLGTTPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGTLAGDKLILHLLQEAAQRPSPPSEDDSGEASSQNSVSSHDKQGAPKKRKAPQPPINIPMPDDQDAYEEIVRLRQERGRLLQKIRGLEQHQERRKQELPEAEASSLHSLERQVQELQQLLAEKQEEKESLGREVESLQSRLSLLENERENTSYDVATLQDEEGELPEFPGAEVLLSKQLSPSAQELLASLQEQVAMLTRQNQELMEKVQVGKPGADGGFRGVGVQVAMLTRQNQELMEKVQVGKPGADGGFRGGGVQVAMLTRQNQELMEKVQILEHFEKDEMEADGPAEVIPLELYDALQAEFDQLRRQHAKALQALEQQEAREALAEEEAASREGKGLGTKTSRNGPVEIELNGTAAPETRVNGVKTTDEEAAGVETTEALSQSLEVVSTMAEATVTKPTDTEASETEGVGAQPLETKATGAEVTEMKTLERGGNPEPKATRAETTSMKTEEPEMKPNGVSAVEEELTGTEAMGVELMIPRALTGPILHPGAAEASEKLQTELETRIRSLEEALRQREREAAAELEAAHGKCEAAEAEAGRLRERVREAEGGRASGVRDGDTGQLRAALEQAREDLRDRDCRLRELEAASARLDEARAGRLLAEEEARGLRAELARREEARLELSRELEALREQLVAATATGEQQRAAAAELGQARDAAEARAAELSAACEEARQGLAELREASEALRQSAVPASEHHRLQEEALELRGRAACLEQEVVATGKEAARLRAELERERVGSMARLEHERIVGALQADVARLQGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALEKAKEKDKKITELSKEVFSLKEALKDQPGAPDSLEVEALRGQVKALREQLEEAAREHSAVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQGR", "length": 1151, "header": "tr|A0AAA9S505-1|A0AAA9SEM9_BOVIN Computationally mapped isoform of Ankyrin repeat domain 24 OS=Bos taurus OX=9913 GN=ANKRD24 PE=4 SV=1 CANONICAL=A0AAA9SEM9-1" }, "locus": { "chromosome": "7", "start_pos": 19842346, "end_pos": 19820938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115268.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115268.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077226.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077226.1" } ] } }, { "isoform_ac": "A0AAA9SEM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9/entry#A0AAA9SEM9-1", "sequence": { "sequence": "MLGAELGVVYGTVAGSGGGQLGGQVLRTQAGGMLSQAPTQDHFPRQLRLSPTDLGSCPPCGPCPIPKPAAARGRRQSQDWGKSDERLLQAVENNDPTRVASLIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMLAHGANAMSTDGAGYNALHLAAKYGHPQCLKQLLQASCAVDTVDSSGWTALHHAAAGGCISCSEMLCSFKAHLNPRDRLGTTPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGTLAGDKLILHLLQEAAQRPSPPSEDDSGEASSQNSVSSHDKQGAPKKRKAPQPPINIPMPDDQDAYEEIVRLRQERGRLLQKIRGLEQHQERRKQELPEAEASSLHSLERQVQELQQLLAEKQEEKESLGREVESLQSRLSLLENERENTSYDVATLQDEEGELPEFPGAEVLLSKQLSPSAQELLASLQEQVAMLTRQNQELMEKVQVGKPGADGGFRGVGVQVAMLTRQNQELMEKVQVGKPGADGGFRGGGVQVAMLTRQNQELMEKVQILEHFEKDEMEADGPAEVIPLELYDALQAEFDQLRRQHAKALQALEQQEAREALAEEEAASREGKGLGTKTSRNGPVEIELNGTAAPETRVNGVKTTDEEAAGVETTEALSQSLEVVSTMAEATVTKPTDTEASETEGVGAQPLETKATGAEVTEMKTLERGGNPEPKATRAETTSMKTEEPEMKPNGVSAVEEELTGTEAMGVELMIPRALTGPILHPGAAEASEKLQTELETRIRSLEEALRQREREAAAELEAAHGKCEAAEAEAGRLRERVREAEGGRASGVRDGDTGQLRAALEQAREDLRDRDCRLRELEAASARLDEARAGRLLAEEEARGLRAELARREEARLELSRELEALREQLVAATATGEQQRAAAAELGQARDAAEARAAELSAACEEARQGLAELREASEALRQSAVPASEHHRLQEEALELRGRAACLEQEVVATGKEAARLRAELERERVGSMARLEHERIVGALQADVARLQGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALEKAKEKDKKITELSKEVFSLKEALKDQPGAPDSLEVEALRGQVKALREQLEEAAREHSAVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQGR", "length": 1214, "header": "tr|A0AAA9SEM9-1|A0AAA9SEM9_BOVIN Isoform 1 of Ankyrin repeat domain 24 OS=Bos taurus OX=9913 GN=ANKRD24 PE=4 SV=1 CANONICAL=A0AAA9SEM9-1" }, "locus": { "chromosome": "7", "start_pos": 19841444, "end_pos": 19820938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135010.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135010.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082300.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082300.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 438, "end_pos": 440 }, { "start_pos": 643, "end_pos": 645 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEM0-1", "uniprot_ac": "A0AAA9SEM0", "uniprot_id": "A0AAA9SEM0_BOVIN", "mass": { "chemical_mass": 92404.0, "monoisotopic_mass": 92404.0 }, "refseq": {}, "gene_names": [ { "name": "SNAP91", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ] } ], "protein_names": [ { "name": "Clathrin coat assembly protein AP180", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#names_and_taxonomy" } ] }, { "name": "91 kDa synaptosomal-associated protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#names_and_taxonomy" } ] }, { "name": "Clathrin coat-associated protein AP180", "type": "synonym", "evidence": [ { "id": "A0AAA9SEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNAP91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0", "locus": { "chromosome": "9", "start_pos": 23474462, "end_pos": 23643555, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009355", "url": "https://www.ensembl.org/id/ENSBTAG00000009355" } ] } } ], "crossref": [ { "id": "A0AAA9SEM0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16985", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16985", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516917", "url": "https://www.ncbi.nlm.nih.gov/gene/516917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VPNLKHA", "url": "https://omabrowser.org/oma/group/VPNLKHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGT4", "url": "https://www.orthodb.org/?gene=F1MGT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22951", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22951", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22951:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22951:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RS01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RS01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S880", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S880", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S880-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S880-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T976", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T976", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T976-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T976-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGT4", "url": "https://www.uniprot.org/uniprotkb/F1MGT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGT4-1", "url": "https://www.uniprot.org/uniprotkb/F1MGT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSVDTFVAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPAPQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 905, "header": "tr|A0AAA9SEM0-1|A0AAA9SEM0_BOVIN Isoform 1 of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RS01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9RS01-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSVDTFVAPSPATTASPAKVDSSGVIDLFGGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 842, "header": "tr|A0AAA9RS01-1|A0AAA9SEM0_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110241.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110241.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075111.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075111.1" } ] } }, { "isoform_ac": "A0AAA9RYE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9RYE4-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSVDTFVAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPAPQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 898, "header": "tr|A0AAA9RYE4-1|A0AAA9SEM0_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077631.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077631.1" } ] } }, { "isoform_ac": "A0AAA9S880-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9S880-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 818, "header": "tr|A0AAA9S880-1|A0AAA9SEM0_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078360.1" } ] } }, { "isoform_ac": "A0AAA9SEM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9SEM0-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSVDTFVAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPAPQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 905, "header": "tr|A0AAA9SEM0-1|A0AAA9SEM0_BOVIN Isoform 1 of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134128.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134128.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084575.1" } ] } }, { "isoform_ac": "A0AAA9SHX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9SHX3-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 842, "header": "tr|A0AAA9SHX3-1|A0AAA9SHX3_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110769.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110769.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084939.1" } ] } }, { "isoform_ac": "A0AAA9STG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9STG6-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTVDTFVAPSPATTASPAKVDSSGVIDLFGGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 846, "header": "tr|A0AAA9STG6-1|A0AAA9STG6_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105814.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105814.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087257.1" } ] } }, { "isoform_ac": "A0AAA9T976-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9T976-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSDAFGSSASEPQPAPQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 875, "header": "tr|A0AAA9T976-1|A0AAA9T976_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105691.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105691.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094550.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094550.1" } ] } }, { "isoform_ac": "A0AAA9TUY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#A0AAA9TUY0-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGDSLAALSSVPSEAQISDPFAPEPTPPATSAETSAAAASASTTTTVTAVTADVDLFGDAFAASPGEAPTASEGATAPAPPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAATAATTAATTAAAATATTSATTTSAPPALDIFGDLFESAPEVAPAPKPEAAPSIDLFGTDAFSSPPQGASPVPESSLTADLLSVDTFVAPSPATTASPAKVDSSGVIDLFGGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 870, "header": "tr|A0AAA9TUY0-1|A0AAA9TUY0_BOVIN Computationally mapped isoform of Clathrin coat assembly protein AP180 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=1 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099507.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099507.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100936.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100936.1" } ] } }, { "isoform_ac": "F1MGT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0/entry#F1MGT4-1", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEAPSSLMETLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSPAGAAAAAPAPAPPSGGATAWGGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPTGQPAPISLVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGVAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 599, "header": "tr|F1MGT4-1|F1MGT4_BOVIN Computationally mapped isoform of Synaptosome associated protein 91 OS=Bos taurus OX=9913 GN=SNAP91 PE=3 SV=4 CANONICAL=A0AAA9SEM0-1" }, "locus": { "chromosome": "9", "start_pos": 23642456, "end_pos": 23477798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012314.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012314.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012314.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012314.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 317, "start_aa": "Thr", "end_pos": 317, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr317", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 408, "start_aa": "Thr", "end_pos": 408, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr408", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 452, "start_aa": "Thr", "end_pos": 452, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr452", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 464, "start_aa": "Thr", "end_pos": 464, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr464", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 510, "start_aa": "Thr", "end_pos": 510, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr510", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 684, "start_aa": "Thr", "end_pos": 684, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr684", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 819, "start_aa": "Thr", "end_pos": 819, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr819", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 881, "start_aa": "Thr", "end_pos": 881, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr881", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GYG9-1", "protein_name": "Clathrin coat assembly protein AP180", "gene_name": "Snap91", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMVPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPVTTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSAAKPSSDLLDLQPDFSGATGGAAAPVPPSSAGGATAWGDLLGEDSLAALSSVPSEAPISDPFAPEPPPPTATTETASASASTTTTVTAITAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTASTAPPVPATAPSPAPTAVATTAATITATAATTTATTSAATAATTAAAPPALDIFGDLFDSAPEVAAAPKPDVAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSVDTFAAPSPATTASPAKVESSGVLDLFGDAFGSSASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPSGQPAPVSVVPPSPAMAASKGLGSDLDSSLASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVTPATWSAGVPPQGTVPPASSVPPGAGAPSVGQPGAGFGMPPAGTGMTMMSQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNIKDFL", "length": 902 }, "evidence": [ { "id": "A0AAA9SEM0", "url": "https://omabrowser.org/oma/group/A0AAA9SEM0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O60641-1", "protein_name": "Clathrin coat assembly protein AP180", "gene_name": "SNAP91", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSSGGAAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATASASASTTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATATTAPPALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL", "length": 907 }, "evidence": [ { "id": "A0AAA9SEM0", "url": "https://omabrowser.org/oma/group/A0AAA9SEM0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q05140-1", "protein_name": "Clathrin coat assembly protein AP180", "gene_name": "Snap91", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMVPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVADEVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATASAAAPVSSAKPSSDLLDLQPDFSGARAGAAAPVPPPTGGATAWGDLLGEDSLAALSSVPSEAPISDPFAPEPSPPTTTTEPASASASATTAVTAATTEVDLFGDAFAASPGEAPAASEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTASTAPPVPATAPSPAPTAVAATAATTTAAAAATTTATTSAAAATTAAAPPALDIFGDLFDSAPEVAAASKPDVAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSGSGFHCAEDDRHVPLFFTAVDAFAAPSPASTASPAKAESSGVIDLFGDAFGSSASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSGDLLMPTMAPSGQPAPVSMVPPSPAMSASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVTPATWSAGVPPQGTVPPTSSVPPGAGAPSVGQPGAGYGMPPAGTGMTMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNIKDFL", "length": 915 }, "evidence": [ { "id": "A0AAA9SEM0", "url": "https://omabrowser.org/oma/group/A0AAA9SEM0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61548-1", "protein_name": "Clathrin coat assembly protein AP180", "gene_name": "Snap91", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMVPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATASAAAPVSSAKPSSDLLDLQPDFSGAAAGAAAPVVPPSGGATAWGDLLGEDSLAALSSVPCEAPISDPFAPEPSPPTTTTEPASASASTTTAVTAVTTEVDLFGDAFAASPGEAPAASEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTASTAPPVPATAPSPAPTAVAATAATTTAAAAATTTATTSAAAATTAAAPPALDIFGDLFDSAPEVAAAPKPDAAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSVDAFAAPSPASTASPAKAESSGVIDLFGDAFGSGASETQPAPQAVSSSSASADLLAGFGGSFMAPSTTPVTPAQNNLLQPSFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPSGQPAPVSMVPPSPAMAASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWNAGEKKLTGGANWQPKVTPATWSAGVPPQGTVPPTSSVPPGAGAPSVGQPGAGFGMPPSGTGMTMMSQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNIKDFL", "length": 901 }, "evidence": [ { "id": "A0AAA9SEM0", "url": "https://omabrowser.org/oma/group/A0AAA9SEM0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "extrinsic component of presynaptic endocytic zone membrane", "id": "GO:0098894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "clathrin coat assembly", "id": "GO:0048268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis", "id": "GO:0072583", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072583", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "vesicle budding from membrane", "id": "GO:0006900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "1-phosphatidylinositol binding", "id": "GO:0005545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005545", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" }, { "name": "clathrin heavy chain binding", "id": "GO:0032050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM0" }, { "id": "PS50942", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50942" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ENTH", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 145, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 317, 408, 452, 464, 510, 684, 819, 881 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEL9-1", "uniprot_ac": "A0AAA9SEL9", "uniprot_id": "A0AAA9SEL9_BOVIN", "mass": { "chemical_mass": 340911.0, "monoisotopic_mass": 340911.0 }, "refseq": {}, "gene_names": [ { "name": "TRANK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat and ankyrin repeat containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRANK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9", "locus": { "chromosome": "22", "start_pos": 10687508, "end_pos": 10591127, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021452", "url": "https://www.ensembl.org/id/ENSBTAG00000021452" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021452", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021452", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509859", "url": "https://www.ncbi.nlm.nih.gov/gene/509859", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509859", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509859", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SQCEVEP", "url": "https://omabrowser.org/oma/group/SQCEVEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21529", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21529", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21529:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21529:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9RSA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U012", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U012", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U012-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U012-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYJ1", "url": "https://www.uniprot.org/uniprotkb/G3MYJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYJ1-1", "url": "https://www.uniprot.org/uniprotkb/G3MYJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESFWPLLQRMDPTAYAELLKESGNQGFKSGNFSLAIRKYDEAIQILLQLYQWGSGDWEVQGPGGGQFNSWVPPRDLAVLLCNKSNAFYSLGKWNEAYGAAKECLQWDPTYVKGYYRAGYSLLGLCQPYEAARMFFEGLRLVRSSQDKTQIADFLVAVFTTMGSDPIVLQSFLPCFDRIFTTGFSNEVWQSVIEKLAKKGLWHSFLLLSVKKDRLPRNLHVPDLSLKSLFEKYVCVGRYEKVEQVPTLVQWLVCMGANVESIGPYPLHTLMRLCIQAGESHLFRWLMDYKPELKGRINQKDEDGCTVLHVVAAHSPGYLTKRQTEDVQMLLRFGADPTLVDRQSRSAVDVLKRNKNFRAIDKINSHLEKLAACSKDLSELSTGEGPANEGDIFQKVCEQLVTYMNSGSHLLQKNFMKQEVVQKFLRILSSLQEIPPDLVYDIDRDCANTFLKFLLEKQKWPEVLLLLTRKVSGQPPLGDCLIKDCDLSTLDLCAILPHLKAWDQRRTLLLDCLIDHGALLEGLQSSQETPLAVCMKHEDFDMAFVLLTKGADPRNISLTEGDTPLHAALHIFLDIKADIGFNFLSHLLDLFWSKPEEFSYLNPNMQDGSGNTLMHILFQKGMLKRTGKLVGLLAKFDINLNLKNKEGKDARYRVKKNDPLLLAWNKALMETRRRGRQDAAAHPGKPPRPAAPAHTAQVKGSSKLLPGAVRAPPKEARVPDSWETLPDAQAPRLEPEAARPCSQRDCLVQDITALIQQLELNSSLPEDCPQGPETLETGAGTEGEKEELQGAPGAGGSDCSGNNPGALEAAEGHVQAGLSAAQLLPEGSRGTEGSDDQDDWSVSEMDICLLDFENMTWEIECTSEMLKKLSSKVMSKVMKKKIILAIQKLGNGEWTPGLRKRLRNLKGSIQLFEAKLDKAARMLWELAIDFSPRCSENPEKIIAAERSMHPTEKSGRVYTEIIRIWDIVLDHNKLSYSIQAICSAYNRGLSCILRKKLKGINKGPVSANMKIQKWIPRCYVEDTEAEKGGARAEPEYFPPASAVETEYNIMKFHSFSTNMASNILNDTTATVEYPFRVGELEYAVIGLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHGYWEKAQQAGSPLLAKQIWLKRRLELEPRKEGQGGEEEEEEEEEGEEEEEEGSVEVGTVGCLEEEQESEACAEGAGGEPGGPGQGEEEPAPQEPPQLEHLHQIFVTKNHVLCQEVQRNFVELSKSTKATSHYKPLEPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRSIVGWSTQEELTITNWQEEEEEAEADGDYSEEEKTVETRPSDSDPRVYVTFEVFVNEIWPKMIKGKTSYNPALIWKEIKSFLKGSFEALSCPGGRLTEEAYKQLGRKRCPNFKEDRSEIYGLFCLYQQIRSHKGYFDDEDVLYNLSRRLSKLKVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNAVDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPRPIVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSSGCREESQPMIEVPLDNCSSSQGRAVTMNPEMYKLLNGELKQLYTAITRARVNLWIFDENPEKRAPAFKYFMKRKFVEVVKTDENKDLDDSMFVKTSTPGEWIAQGDYYAKHQCWKVAAKCYQKGGALEKEKLALAHNTALNMKSKKVSLKEKQVEYLELAKTYLECKEPKLCLKCLSYAKEFQLCAQLCERLGKVRDAAYFYKRSQCYKDASRCFEQIQEFDLALKMYCQEELFEEAAMAVEKYEEMLRAKALPVSKLTYSASQFYLEAAAKYLSMNKTKEMMAVLSKLDIEDQLVFLTSRKRLTEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLAAARLNVARDSDVDLTKAILREALDLCHQTNQVSGIAQAHFLQGVIMRDFLKLKDAFLKFDTLNHSAGAVEALYEATSHCEVQPEDVLALAPGGLGVLLDLVRALRRVTTNAEKEMVKSCFEFFGILQVDAKYCQIAQNDPGPILRIISDLDLNLKEKKTKDHFLIMMDQVKLALNKHLLSRLCQITESLLAKTYPGVCMKFLVGLKCEDGRCEDFHRPLRRHEAKCLVQSKIHLVAIKGLLLEAKRVFSKVLAEGLEEIDYILSLDKHGLCESLLNVVFPKHFHQRVLSENPMACKEVLKPHYKSFRSYRSALKEYIHVLFQNERARSRRESTDLWLSAMQAFLLSSSYPDELDKLLYQEEDQYNRELKALQSEQEKRGRDRGSRMKGIEGKFGMLAPNKDDESAEKPHLCFIRLLQDSIRQFYVCRNPEDYKRRFFRFMNVLVKRCKEPLIPSIGNTVALLELQFIHCGVVLARLSKNAVLCLPKSYIALLHYWEFLFSKKDQEPGDVFAIIQEYRPKDLTRAIQEFRFHLSYLVKVLCGCENANFNVLLDAFSDIDYVVSGEAERTLVLCLVMLVNTKGVLQPSCKPLLSSQFQELEARLQLLSIECPGRVPERLLRVVKQVQLAVNVKSVAEALQDLLFERDEEFLMDCHWQWDSGHAKGTAVRGLYHEEVRLNRLFSMDPVGYLAEPEYEVGQDEPEELALEGDHLLDAVLSQKLRRASIRQKMRRVCLVVSLCIRWRRGRAGGQAEHFREEGREPAAGNFKKADVDRTQCDLCGVKFARGPENYFTPDQAFEGAAPEAVALSGTELEDEQGWERSSESYEQHILLESHQSQQVAYQRYLEFFREKVDPAMEEGKLVVQDMEQSAWGRKHLGSKEHSHILQRKVQENIKKVSDSVEDLYRRKAWADAEEVMARLVNILIPSVRDAQEWLRKTELHQEEGVIQEDVYENEVEDFGELRPRRRPRKCAKKKH", "length": 2996, "header": "tr|A0AAA9SEL9-1|A0AAA9SEL9_BOVIN Isoform 1 of Tetratricopeptide repeat and ankyrin repeat containing 1 OS=Bos taurus OX=9913 GN=TRANK1 PE=4 SV=1 CANONICAL=A0AAA9SEL9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9/entry#A0AAA9RSA1-1", "sequence": { "sequence": "MLAAGWGPGIQKRALRQTAFAGQSSQGSCGISSCWPSQPWSFSGFIFPSQPEDQLMCMWGKSQGESHLFRWLMDYKPELKGRINQKDEDGCTVLHVVAAHSPGYLTKRQTEDVQMLLRFGADPTLVDRQSRSAVDVLKRNKNFRAIDKINSHLEKLAACSKDLSELSTGEGPANEGDIFQKVCEQLVTYMNSGSHLLQKNFMKQEVVQKFLRILSSLQEIPPDLVYDIDRDCANTFLKFLLEKQKWPEVLLLLTRKVSGQPPLGDCLIKDCDLSTLDLCAILPHLKAWDQRRTLLLDCLIDHGALLEGLQSSQETPLAVCMKHEDFDMAFVLLTKGADPRNISLTEGDTPLHAALHIFLDIKADIGFNFLSHLLDLFWSKPEEFSYLNPNMQDGSGNTLMHILFQKGMLKRTGKLVGLLAKFDINLNLKNKEGKDARYRVKKNDPLLLAWNKALMETRRRGRQDAAAHPGKPPRPAAPAHTAQVKGSSKLLPGAVRAPPKEARVPDSWETLPDAQAPRLEPEAARPCSQRDCLVQDITALIQQLELNSSLPEDCPQGPETLETGAGTEGEKEELQGAPGAGGSDCSGNNPGALEAAEGHVQAGLSAAQLLPEGSRGTEGSDDQDDWSVSEMDICLLDFENMTWEIECTSEMLKKLSSKVMSKVMKKKIILAIQKLGNGEWTPGLRKRLRNLKGSIQLFEAKLDKAARMLWELAIDFSPRCSENPEKIIAAERSMHPTEKSGRVYTEIIRIWDIVLDHNKLSYSIQAICSAYNRGLSCILRKKLKGINKGPVSANMKIQKWIPRCYVEDTEAEKGGARAEPEYFPPASAVETEYNIMKFHSFSTNMASNILNDTTATVEYPFRVGELEYAVIGLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHGYWEKAQQAGSPLLAKQIWLKRRLELEPRKEGQGGEEEEEEEEEGEEEEEEGSVEVGTVGCLEEEQESEACAEGAGGEPGGPGQGEEEPAPQEPPQLEHLHQIFVTKNHVLCQEVQRNFVELSKSTKATSHYKPLEPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRSIVGWSTQEELTITNWQEEEEEAEADGDYSEEEKTVETRPSDSDPRVYVTFEVFVNEIWPKMIKGKTSYNPALIWKEIKSFLKGSFEALSCPGGRLTEEAYKQLGRKRCPNFKEDRSEIYGLFCLYQQIRSHKGYFDDEDVLYNLSRRLSKLKVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNAVDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPRPIVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSSGCREESQPMIEVPLDNCSSSQGRAVTMNPEMYKLLNGELKQLYTAITRARVNLWIFDENPEKRAPAFKYFMKRKFVEVVKTDENKDLDDSMFVKTSTPGEWIAQGDYYAKHQCWKVAAKCYQKGGALEKEKLALAHNTALNMKSKKVSLKEKQVEYLELAKTYLECKEPKLCLKCLSYAKEFQLCAQLCERLGKVRDAAYFYKRSQCYKDASRCFEQIQEFDLALKMYCQEELFEEAAMAVEKYEEMLRAKALPVSKLTYSASQFYLEAAAKYLSMNKTKEMMAVLSKLDIEDQLVFLTSRKRLTEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLAAARLNVARDSDVDLTKAILREALDLCHQTNQVSGIAQAHFLQGVIMRDFLKLKDAFLKFDTLNHSAGAVEALYEATSHCEVQPEDVLALAPGGLGVLLDLVRALRRVTTNAEKEMVKSCFEFFGILQVDAKYCQIAQNDPGPILRIISDLDLNLKEKKTKDHFLIMMDQVKLALNKHLLSRLCQITESLLAKTYPGVCMKFLVGLKCEDGRCEDFHRPLRRHEAKCLVQSKIHLVAIKGLLLEAKRVFSKVLAEGLEEIDYILSLDKHGLCESLLNVVFPKHFHQRVLSENPMACKEVLKPHYKSFRSYRSALKEYIHVLFQNERARSRRESTDLWLSAMQAFLLSSSYPDELDKLLYQEEDQYNRELKALQSEQEKRGRDRGSRMKGIEGKFGMLAPNKDDESAEKPHLCFIRLLQDSIRQFYVCRNPEDYKRRFFRFMNVLVKRCKEPLIPSIGNTVALLELQFIHCGVVLARLSKNAVLCLPKSYIALLHYWEFLFSKKDQEPGDVFAIIQEYRPKDLTRAIQEFRFHLSYLVKVLCGCENANFNVLLDAFSDIDYVVSGEAERTLVLCLVMLVNTKGVLQPSCKPLLSSQFQELEARLQLLSIECPGRVPERLLRVVKQVQLAVNVKSVAEALQDLLFERDEEFLMDCHWQWDSGHAKGTAVRGLYHEEVRLNRLFSMDPVGYLAEPEYEVGQDEPEELALEGDHLLDAVLSQKLRRASIRQKMRRVCLVVSLCIRWRRGRAGGQAEHFREEGREPAAGNFKKADVDRTQCDLCGVKFARGPENYFTPDQAFEGAAPEAVALSGTELEDEQGWERSSESYEQHILLESHQSQQVAYQRYLEFFREKVDPAMEEGKLVVQDMEQSAWGRKHLGSKEHSHILQRKVQENIKKVSDSVEDLYRRKAWADAEEVMARLVNILIPSVRDAQEWLRKTELHQEEGVIQEDVYENEVEDFGELRPRRRPRKCAKKKH", "length": 2782, "header": "tr|A0AAA9RSA1-1|A0AAA9SEL9_BOVIN Computationally mapped isoform of Tetratricopeptide repeat and ankyrin repeat containing 1 OS=Bos taurus OX=9913 GN=TRANK1 PE=4 SV=1 CANONICAL=A0AAA9SEL9-1" }, "locus": { "chromosome": "22", "start_pos": 10686504, "end_pos": 10627953, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093023.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093023.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075376.1" } ] } }, { "isoform_ac": "A0AAA9SEL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9/entry#A0AAA9SEL9-1", "sequence": { "sequence": "MESFWPLLQRMDPTAYAELLKESGNQGFKSGNFSLAIRKYDEAIQILLQLYQWGSGDWEVQGPGGGQFNSWVPPRDLAVLLCNKSNAFYSLGKWNEAYGAAKECLQWDPTYVKGYYRAGYSLLGLCQPYEAARMFFEGLRLVRSSQDKTQIADFLVAVFTTMGSDPIVLQSFLPCFDRIFTTGFSNEVWQSVIEKLAKKGLWHSFLLLSVKKDRLPRNLHVPDLSLKSLFEKYVCVGRYEKVEQVPTLVQWLVCMGANVESIGPYPLHTLMRLCIQAGESHLFRWLMDYKPELKGRINQKDEDGCTVLHVVAAHSPGYLTKRQTEDVQMLLRFGADPTLVDRQSRSAVDVLKRNKNFRAIDKINSHLEKLAACSKDLSELSTGEGPANEGDIFQKVCEQLVTYMNSGSHLLQKNFMKQEVVQKFLRILSSLQEIPPDLVYDIDRDCANTFLKFLLEKQKWPEVLLLLTRKVSGQPPLGDCLIKDCDLSTLDLCAILPHLKAWDQRRTLLLDCLIDHGALLEGLQSSQETPLAVCMKHEDFDMAFVLLTKGADPRNISLTEGDTPLHAALHIFLDIKADIGFNFLSHLLDLFWSKPEEFSYLNPNMQDGSGNTLMHILFQKGMLKRTGKLVGLLAKFDINLNLKNKEGKDARYRVKKNDPLLLAWNKALMETRRRGRQDAAAHPGKPPRPAAPAHTAQVKGSSKLLPGAVRAPPKEARVPDSWETLPDAQAPRLEPEAARPCSQRDCLVQDITALIQQLELNSSLPEDCPQGPETLETGAGTEGEKEELQGAPGAGGSDCSGNNPGALEAAEGHVQAGLSAAQLLPEGSRGTEGSDDQDDWSVSEMDICLLDFENMTWEIECTSEMLKKLSSKVMSKVMKKKIILAIQKLGNGEWTPGLRKRLRNLKGSIQLFEAKLDKAARMLWELAIDFSPRCSENPEKIIAAERSMHPTEKSGRVYTEIIRIWDIVLDHNKLSYSIQAICSAYNRGLSCILRKKLKGINKGPVSANMKIQKWIPRCYVEDTEAEKGGARAEPEYFPPASAVETEYNIMKFHSFSTNMASNILNDTTATVEYPFRVGELEYAVIGLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHGYWEKAQQAGSPLLAKQIWLKRRLELEPRKEGQGGEEEEEEEEEGEEEEEEGSVEVGTVGCLEEEQESEACAEGAGGEPGGPGQGEEEPAPQEPPQLEHLHQIFVTKNHVLCQEVQRNFVELSKSTKATSHYKPLEPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRSIVGWSTQEELTITNWQEEEEEAEADGDYSEEEKTVETRPSDSDPRVYVTFEVFVNEIWPKMIKGKTSYNPALIWKEIKSFLKGSFEALSCPGGRLTEEAYKQLGRKRCPNFKEDRSEIYGLFCLYQQIRSHKGYFDDEDVLYNLSRRLSKLKVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNAVDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPRPIVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSSGCREESQPMIEVPLDNCSSSQGRAVTMNPEMYKLLNGELKQLYTAITRARVNLWIFDENPEKRAPAFKYFMKRKFVEVVKTDENKDLDDSMFVKTSTPGEWIAQGDYYAKHQCWKVAAKCYQKGGALEKEKLALAHNTALNMKSKKVSLKEKQVEYLELAKTYLECKEPKLCLKCLSYAKEFQLCAQLCERLGKVRDAAYFYKRSQCYKDASRCFEQIQEFDLALKMYCQEELFEEAAMAVEKYEEMLRAKALPVSKLTYSASQFYLEAAAKYLSMNKTKEMMAVLSKLDIEDQLVFLTSRKRLTEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLAAARLNVARDSDVDLTKAILREALDLCHQTNQVSGIAQAHFLQGVIMRDFLKLKDAFLKFDTLNHSAGAVEALYEATSHCEVQPEDVLALAPGGLGVLLDLVRALRRVTTNAEKEMVKSCFEFFGILQVDAKYCQIAQNDPGPILRIISDLDLNLKEKKTKDHFLIMMDQVKLALNKHLLSRLCQITESLLAKTYPGVCMKFLVGLKCEDGRCEDFHRPLRRHEAKCLVQSKIHLVAIKGLLLEAKRVFSKVLAEGLEEIDYILSLDKHGLCESLLNVVFPKHFHQRVLSENPMACKEVLKPHYKSFRSYRSALKEYIHVLFQNERARSRRESTDLWLSAMQAFLLSSSYPDELDKLLYQEEDQYNRELKALQSEQEKRGRDRGSRMKGIEGKFGMLAPNKDDESAEKPHLCFIRLLQDSIRQFYVCRNPEDYKRRFFRFMNVLVKRCKEPLIPSIGNTVALLELQFIHCGVVLARLSKNAVLCLPKSYIALLHYWEFLFSKKDQEPGDVFAIIQEYRPKDLTRAIQEFRFHLSYLVKVLCGCENANFNVLLDAFSDIDYVVSGEAERTLVLCLVMLVNTKGVLQPSCKPLLSSQFQELEARLQLLSIECPGRVPERLLRVVKQVQLAVNVKSVAEALQDLLFERDEEFLMDCHWQWDSGHAKGTAVRGLYHEEVRLNRLFSMDPVGYLAEPEYEVGQDEPEELALEGDHLLDAVLSQKLRRASIRQKMRRVCLVVSLCIRWRRGRAGGQAEHFREEGREPAAGNFKKADVDRTQCDLCGVKFARGPENYFTPDQAFEGAAPEAVALSGTELEDEQGWERSSESYEQHILLESHQSQQVAYQRYLEFFREKVDPAMEEGKLVVQDMEQSAWGRKHLGSKEHSHILQRKVQENIKKVSDSVEDLYRRKAWADAEEVMARLVNILIPSVRDAQEWLRKTELHQEEGVIQEDVYENEVEDFGELRPRRRPRKCAKKKH", "length": 2996, "header": "tr|A0AAA9SEL9-1|A0AAA9SEL9_BOVIN Isoform 1 of Tetratricopeptide repeat and ankyrin repeat containing 1 OS=Bos taurus OX=9913 GN=TRANK1 PE=4 SV=1 CANONICAL=A0AAA9SEL9-1" }, "locus": { "chromosome": "22", "start_pos": 10686504, "end_pos": 10612323, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105202.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105202.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082056.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082056.1" } ] } }, { "isoform_ac": "A0AAA9U012-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9/entry#A0AAA9U012-1", "sequence": { "sequence": "MWDARVTRMDPTAYAELLKESGNQGFKSGNFSLAIRKYDEAIQILLQLYQWGSGDWEVQGPGGGQFNSWVPPRDLAVLLCNKSNAFYSLGKWNEAYGAAKECLQWDPTYVKGYYRAGYSLLGLCQPYEAARMFFEGLRLVRSSQDKTQIADFLVAVFTTMGSDPIVLQSFLPCFDRIFTTGFSNEVWQSVIEKLAKKGLWHSFLLLSVKKDRLPRNLHVPDLSLKSLFEKYVCVGRYEKVEQVPTLVQWLVCMGANVESIGPYPLHTLMRLCIQAGESHLFRWLMDYKPELKGRINQKDEDGCTVLHVVAAHSPGYLTKRQTEDVQMLLRFGADPTLVDRQSRSAVDVLKRNKNFRAIDKINSHLEKLAACSKDLSELSTGEGPANEGDIFQKVCEQLVTYMNSGSHLLQKNFMKQEVVQKFLRILSSLQEIPPDLVYDIDRDCANTFLKFLLEKQKWPEVLLLLTRKVSGQPPLGDCLIKDCDLSTLDLCAILPHLKAWDQRRTLLLDCLIDHGALLEGLQSSQETPLAVCMKHEDFDMAFVLLTKGADPRNISLTEGDTPLHAALHIFLDIKADIGFNFLSHLLDLFWSKPEEFSYLNPNMQDGSGNTLMHILFQKGMLKRTGKLVGLLAKFDINLNLKNKEGKDARYRVKKNDPLLLAWNKALMETRRRGRQDAAAHPGKPPRPAAPAHTAQVKGSSKLLPGAVRAPPKEARVPDSWETLPDAQAPRLEPEAARPCSQRDCLVQDITALIQQLELNSSLPEDCPQGPETLETGAGTEGEKEELQGAPGAGGSDCSGNNPGALEAAEGHVQAGLSAAQLLPEGSRGTEGSDDQDDWSVSEMDICLLDFENMTWEIECTSEMLKKLSSKVMSKVMKKKIILAIQKLGNGEWTPGLRKRLRNLKGSIQLFEAKLDKAARMLWELAIDFSPRCSENPEKIIAAERSMHPTEKSGRVYTEIIRIWDIVLDHNKLSYSIQAICSAYNRGLSCILRKKLKGINKGPVSANMKIQKWIPRCYVEDTEAEKGGARAEPEYFPPASAVETEYNIMKFHSFSTNMASNILNDTTATVEYPFRVGELEYAVIGLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHGYWEKAQQAGSPLLAKQIWLKRRLELEPRKEGQGGEEEEEEEEEGEEEEEEGSVEVGTVGCLEEEQESEACAEGAGGEPGGPGQGEEEPAPQEPPQLEHLHQIFVTKNHVLCQEVQRNFVELSKSTKATSHYKPLEPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRSIVGWSTQEELTITNWQEEEEEAEADGDYSEEEKTVETRPSDSDPRVYVTFEVFVNEIWPKMIKGKTSYNPALIWKEIKSFLKGSFEALSCPGGRLTEEAYKQLGRKRCPNFKEDRSEIYGLFCLYQQIRSHKGYFDDEDVLYNLSRRLSKLKVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNAVDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPRPIVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSSGCREESQPMIEVPLDNCSSSQGRAVTMNPEMYKLLNGELKQLYTAITRARVNLWIFDENPEKRAPAFKYFMKRKFVEVVKTDENKDLDDSMFVKTSTPGEWIAQGDYYAKHQCWKVAAKCYQKGGALEKEKLALAHNTALNMKSKKVSLKEKQVEYLELAKTYLECKEPKLCLKCLSYAKEFQLCAQLCERLGKVRDAAYFYKRSQCYKDASRCFEQIQEFDLALKMYCQEELFEEAAMAVEKYEEMLRAKALPVSKLTYSASQFYLEAAAKYLSMNKTKEMMAVLSKLDIEDQLVFLTSRKRLTEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLAAARLNVARDSDVDLTKAILREALDLCHQTNQVSGIAQAHFLQGVIMRDFLKLKDAFLKFDTLNHSAGAVEALYEATSHCEVQPEDVLALAPGGLGVLLDLVRALRRVTTNAEKEMVKSCFEFFGILQVDAKYCQIAQNDPGPILRIISDLDLNLKEKKTKDHFLIMMDQVKLALNKHLLSRLCQITESLLAKTYPGVCMKFLVGLKCEDGRCEDFHRPLRRHEAKCLVQSKIHLVAIKGLLLEAKRVFSKVLAEGLEEIDYILSLDKHGLCESLLNVVFPKHFHQRVLSENPMACKEVLKPHYKSFRSYRSALKEYIHVLFQNERARSRRESTDLWLSAMQAFLLSSSYPDELDKLLYQEEDQYNRELKALQSEQEKRGRDRGSRMKGIEGKFGMLAPNKDDESAEKPHLCFIRLLQDSIRQFYVCRNPEDYKRRFFRFMNVLVKRCKEPLIPSIGNTVALLELQFIHCGVVLARLSKNAVLCLPKSYIALLHYWEFLFSKKDQEPGDVFAIIQEYRPKDLTRAIQEFRFHLSYLVKVLCGCENANFNVLLDAFSDIDYVVSGEAERTLVLCLVMLVNTKGVLQPSCKPLLSSQFQELEARLQLLSIECPGRVPERLLRVVKQVQLAVNVKSVAEALQDLLFERDEEFLMDCHWQWDSGHAKGTAVRGLYHEEVRLNRLFSMDPVGYLAEPEYEVGQDEPEELALEGDHLLDAVLSQKLRRASIRQKMRRVCLVVSLCIRWRRGRAGGQAEHFREEGREPAAGNFKKADVDRTQCDLCGVKFARGPENYFTPDQAFEGAAPEAVALSGTELEDEQGWERSSESYEQHILLESHQSQQVAYQRYLEFFREKVDPAMEEGKLVVQDMEQSAWGRKHLGSKEHSHILQRKVQENIKKVSDSVEDLYRRKAWADAEEVMARLVNILIPSVRDAQEWLRKTELHQEEGVIQEDVYENEVEDFGELRPRRRPRKCAKKKH", "length": 2994, "header": "tr|A0AAA9U012-1|A0AAA9U012_BOVIN Computationally mapped isoform of Tetratricopeptide repeat and ankyrin repeat containing 1 OS=Bos taurus OX=9913 GN=TRANK1 PE=4 SV=1 CANONICAL=A0AAA9SEL9-1" }, "locus": { "chromosome": "22", "start_pos": 10686504, "end_pos": 10591437, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121567.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121567.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102900.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102900.1" } ] } }, { "isoform_ac": "G3MYJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9/entry#G3MYJ1-1", "sequence": { "sequence": "MWDARVTRMDPTAYAELLKESGNQGFKSGNFSLAIRKYDEAIQILLQLYQWGVPPRDLAVLLCNKSNAFYSLGKWNEAYGAAKECLQWDPTYVKGYYRAGYSLLGLCQPYEAARMFFEGLRLVRSSQDKTQIADFLVAVFTTMGSDPIVLQSFLPCFDRIFTTGFSNEVWQSVIEKLAKKGLWHSFLLLSVKKDRLPRNLHVPDLSLKSLFEKYVCVGRYEKVEQVPTLVQWLVCMGANVESIGPYPLHTLMRLCIQAGESHLFRWLMDYKPELKGRINQKDEDGCTVLHVVAAHSPGYLTKRQTEDVQMLLRFGADPTLVDRQSRSAVDVLKRNKNFRAIDKINSHLEKLAACSKDLSELSTGEGPANEGDIFQKVCEQLVTYMNSGSHLLQKNFMKQEVVQKFLRILSSLQEIPPDLVYDIDRDCANTFLKFLLEKQKWPEVLLLLTRKVSGQPPLGDCLIKDCDLSTLDLCAILPHLKAWDQRRTLLLDCLIDHGALLEGLQSSQETPLAVCMKHEDFDMAFVLLTKGADPRNISLTEGDTPLHAALHIFLDIKADIGFNFLSHLLDLFWSKPEEFSYLNPNMQDGSGNTLMHILFQKGMLKRTGKLVGLLAKFDINLNLKNKEGKDARYRVKKNDPLLLAWNKALMETRRRGRQDAAAHPGKPPRPAAPAHTAQVKGSSKLLPGAVRAPPKEARVPDSWETLPDAQAPRLEPEAARPCSQRDCLVQDITALIQQLELNSSLPEDCPQGPETLETGAGTEGEKEELQGAPGAGGSDCSGNNPGALEAAEGHVQAGLSAAQLLPEGSRGTEGSDDQDDWSVSEMDICLLDFENMTWEIECTSEMLKKLSSKVMSKVMKKKIILAIQKLGNGEWTPGLRKRLRNLKGSIQLFEAKLDKAARMLWELAIDFSPRCSENPEKIIAAERSMHPTEKSGRVYTEIIRIWDIVLDHNKLSYSIQAICSAYNRGLSCILRKKLKGINKGPVSANMKIQKWIPRCYVEDTEAEKGGARAEPEYFPPASAVETEYNIMKFHSFSTNMASNILNDTTATVEYPFRVGELEYAVIGLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHGYWEKAQQAGSPLLAKQIWLKRRLELEPRKEGQGGEEEEEEEEEGEEEEEEGSVEVGTVGCLEEEQESEACAEGAGGEPGGPGQGEEEPAPQEPPQLEHLHQIFVTKNHVLCQEVQRNFVELSKSTKATSHYKPLEPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRSIVGWSTQEELTITNWQEEEEEAEADGDYSEEEKTVETRPSDSDPRVYVTFEVFVNEIWPKMIKGKTSYNPALIWKEIKSFLKGSFEALSCPGGRLTEEAYKQLGRKRCPNFKEDRSEIYGLFCLYQQIRSHKGYFDDEDVLYNLSRRLSKLKVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNAVDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPRPIVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSSGCREESQPMIEVPLDNCSSSQGRAVTMNPEMYKLLNGELKQLYTAITRARVNLWIFDENPEKRAPAFKYFMKRKFVEVVKTDENKDLDDSMFVKTSTPGEWIAQGDYYAKHQCWKVAAKCYQKGGALEKEKLALAHNTALNMKSKKVSLKEKQVEYLELAKTYLECKEPKLCLKCLSYAKEFQLCAQLCERLGKVRDAAYFYKRSQCYKDASRCFEQIQEFDLALKMYCQEELFEEAAMAVEKYEEMLRAKALPVSKLTYSASQFYLEAAAKYLSMNKTKEMMAVLSKLDIEDQLVFLTSRKRLTEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLAAARLNVARDSDVDLTKAILREALDLCHQTNQVSGIAQAHFLQGVIMRDFLKLKDAFLKFDTLNHSAGAVEALYEATSHCEVQPEDVLALAPGGLGVLLDLVRALRRVTTNAEKEMVKSCFEFFGILQVDAKYCQIAQNDPGPILRIISDLDLNLKEKKTKDHFLIMMDQVKLALNKHLLSRLCQITESLLAKTYPGVCMKFLVGLKCEDGRCEDFHRPLRRHEAKCLVQSKIHLVAIKGLLLEAKRVFSKVLAEGLEEIDYILSLDKHGLCESLLNVVFPKHFHQRVLSENPMACKEVLKPHYKSFRSYRSALKEYIHVLFQNERARSRRESTDLWLSAMQAFLLSSSYPDELDKLLYQEEDQYNRELKALQSEQEKRGRDRGSRMKGIEGKFGMLAPNKDDESAEKPHLCFIRLLQDSIRQFYVCRNPEDYKRRFFRFMNVLVKRCKEPLIPSIGNTVALLELQFIHCGVVLARLSKNAVLCLPKSYIALLHYWEFLFSKKDQEPGDVFAIIQEYRPKDLTRAIQEFRFHLSYLVKVLCGCENANFNVLLDAFSDIDYVVSGEAERTLVLCLVMLVNTKGVLQPSCKPLLSSQFQELEARLQLLSIECPGRVPERLLRVVKQVQLAVNVKSVAEALQDLLFERDEEFLMDCHWQWDSGHAKGTAVRGLYHEEVRLNRLFSMDPVGYLAEPEYEVGQDEPEELALEGDHLLDAVLSQKLRRASIRQKMRRVCLVVSLCIRWRRGRAGGQAEHFREEGREPAAGNFKKADVDRTQCDLCGVKFARGPENYFTPDQAFEGAAPEAVALSGTELEDEQGWERSSESYEQHILLESHQSQQVAYQRYLEFFREKVDPAMEEGKLVVQDMEQSAWGRKHLGSKEHSHILQRKVQENIKKVSDSVEDLYRRKAWADAEEVMARLVNILIPSVRDAQEWLRKTELHQEEGVIQEDVYENEVEDFGELRPRRRPRKCAKKKH", "length": 2977, "header": "tr|G3MYJ1-1|G3MYJ1_BOVIN Computationally mapped isoform of Tetratricopeptide repeat and ankyrin repeat containing 1 OS=Bos taurus OX=9913 GN=TRANK1 PE=4 SV=2 CANONICAL=A0AAA9SEL9-1" }, "locus": { "chromosome": "22", "start_pos": 10686504, "end_pos": 10591437, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065280.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065280.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054624.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054624.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1720, "start_aa": "Thr", "end_pos": 1720, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1720", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509859", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509859", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YQJ5-1", "protein_name": "Tetratricopeptide repeat and ankyrin repeat containing 1", "gene_name": "TRANK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVEMICSPDFILDEPDQEHDPERVRCTPNMWRTFTKTAPESMDAMEYAQFMKQDGNQDFKNGNYALAIRKYDQALYMLVQLRQWGLCSGDIAVLYCNKSTCLYNLGKWREAMLSAFESLRWDPQYVKAYYRAGHSLIMLSNAYNAVCMFHRGLTLLNASVDQAQVADFIAGIFTSVNDERVLPPTFYPAYDYIFSARFDALIWQSVMEKLAQKGKWQSFLLLLSKKKDLPTNLRVNQLPLKNLFETFELYGCDETMQNVAELVKWLISIGAKVESIGVYPLHAVIRLCIKAKKNHIFRWLLSQRPDLKDRINQQDRDGCTLLHIVASSSDYSRKRSQTEDVLMLLNFGVDPTIPDARSRNVIDILKKNKNFDAVKAVSNHIEKHTSSSVELEDEDRRRAVVDSFLDALEQFVKFCSFENGLHHKNILKEDVFQRFLKLLSSVKEIPDGVVCNISQACANSIVKLLLKKQMWHEVLLLLTGKANGENASDGGLLKACSLSDVDIGSIIQQCDRLDERVHLIRCLVERGALPDGTGAKSEIPLQICLKKNYIELVYLLLTKGADPRNISFAKGDTPLHAAVHICLDKRDGTGINILNYLLDLFASRPSDFPYLNPNVQDDNGNTVMHVIFQRGFSKQAKRIMDSLAKFDVNFNIKNKLGRDVRHRIKKNDPLLLAWNTAVSEKKKYRQDIAGQLVKTPKPTPASDVSQPKNAGRSSSGSLLKVPSGNTARNDVKTQSSVKTKNDQLSKQEMEKIKNPLTMQESLVQEIAALIQQLKWGDALRKDNSVVQKQSSGQTNLEEGKSASLQLSGSAVYSEGRGDDREKKKGVQEFSVGLSNGEKEAPDEEMILDIEAYVQEFDNMTWEIECTPEALKTLGSKDVPHYLKTKTIMTIKRLGNGEWTKGLQKPLKHLKADIQLYEAKLGKGARMLWELAIDFSPRCSESAEKIMETEQTKSLPEKSGRVYTEMIRIWAIVLDHCKLNRVLDNICLSYNRGLSCILRKKLKGINEGHQNYNVTMHKRVPRCYVEDLEREKSKEHTIPEYFPPASAAEMEYNIMKFHSFSTNMALNIINDVHSAVEYPFRVGELEYAVIDLNPKPMEPIILIGRSGTGKTTCCLYRLWKKFYSYWEKSTMANSPLLERQTWRQRQCSDVEKARLENEECEEKQDNDDSSEEQVSEEQDQDSEDEEVATGTSDAETSPCDDHEEGQKCNSEEPNTLEHLHQIFVTKNPVLCQEVQKNFIELSKSSKVTSHFKPLEPNVHRLQDVKDENFPLFITSKQLLLLLDASLPDPFFPRNEDGSLKRTIVGWSPQEELVIPNWQDEDEECNAEAEDGDEERTADGYSRESDPRTFVTYDLFANEIWPKMIKGKSLYNPALVWKEIKSFLKGSFEALSCFGGKLTEEQYKKLGRKRSPNFTEDRSEIYHLFCLYQQIRSQRGYFDEEDLLYNLSQRLSQLGELPWSIHEFYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASKNTVDKKQRVRKPKRIYQLYQNYRSHSGILSLASGVVDLLQYYFPESFDRLPKDCGLFDGPKPTVLESCSFSDLAILLRGNKRKTQPIEFGAHQVVLVANETAKEKIPEELSLALVLTVYEAKGLEFDDVLLYNFFTDSEASKEWKIISSYTPDSDVQVGSKLLIEMPLEDATAMQKRPTSFNAEMYKMLNGELKQLYTAITRARVNLWIFDENSDKRAPAFKYFIKRGFVQVVKTDENKDLDDSMFAKTSSPEEWIAQGDYYAKHQFWEVAAKCYQKGGAAEKSKLALAHDAVLKVHSKKSSPREKQMEYMTLAKTYLECGESKLSLKCLFQSKEFRLCAELCKKLGKMKDAAVYYQKNQCYKEASECYEQIEEFDLAIKMYCQEELYEEAAKAVERYEEMLNARGQMVSKLSCTANQLYLEAAAKYLSVNRIEEMMQVLSKLDIEDQLEFLKSRGCLHQTADLLKREGRQEEAAKLMKQHGYALEAANLTAIKEFRASCLLAAVRAGTTHCSESNLVDREIMLREALELCEQTNQKSGIAEALFLQGAPKRDFTKLSNAYFQFLSVNHSAGAVEVLFVLSRCSAPSQEILCKATHGLMALLDLVKSLKKATTNVEKDMVKSCFAYFGIIPTGDSCCQVSQNEAEPILKFLLDKASLKERKTKGNFSVSTEAVKSALKQHLLSRLCSITHELLNKHYPDICMKFIVGLNCEDSTCGDFHKPLMRHEARMVFQCKMNLAAINGLLLEATHTFPKELLSHCKSFDGLLTSDKYVSCKALLETFFPNHFHLRILSENPKACKEILGFSNITSKPCRALLNEYISFKFKDEDARARRESSDLWLSAMKVFLLSSGYPEEFEKLLFKEEDDYNRELNLALSKAKSSPKSKSHGGKIKGIDGRHGMLQPDKKTENAGRTHLCFIRLLQSSFEQFYVYKNPESCKRLFFRFMNVLVKKCTRYLIPSIGNTVMLLEFQYIICCAVLMRLNKNVTLCLPKSYIALVHYWDFLFRNKGRSKEFTETFSIIQEYRPKDILVAEQNFRFHLCYLAKILCGVHENFSVLLDAFEDPDCVTSGEAERTVVLSLVMILNADQVQNSMCKYLLSQLFPEIKGMLKAMRKDSPSKVPVRLLKVVEQVAAASGVREVAASLQELLIERDEEYLFDCRWRWDSVYTQGYAPIRGILYENVNFDRFIASLDKTEYADEIEKELESDQCLEDQKDPLEVIALNKQQKQEQKASALRHLYRVFHFVFVCMRWKRKACCKAEPVAVEGEEFLSDIFKKADIDQTQCDLCGVRFIQSSENYFSQTESVEADTSEAVTPTEEKMQVEGNAIIAASEAYMEHRNTDKHRNNNAAYKNYADFFRRWIDPKIRDGLDVVEAITERTYTQDHLAYKEGSNLCQRKIKENIKKISDAVEEIYERKAWAEAEEIITEHANKLFAVTDEAYKWLKKMDLQRIKEEDFVHDRDLENEVEDESMAFEELAYKKPSRKKGRYGKW", "length": 3008 }, "evidence": [ { "id": "A0AAA9SEL9", "url": "https://omabrowser.org/oma/group/A0AAA9SEL9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZSG2-1", "protein_name": "Tetratricopeptide repeat and ankyrin repeat containing 1", "gene_name": "Trank1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASRTAGRRWPPRRRSSRRGPTPRSRAPGAKLSAPEAGPPRRGPLPRGGAGRDTLLGAKATPSSPATRRYVTALGPPQPRGNTDSACAALPQPVPHEPREAAFRLVPGSERRASVSPARIPRRRRRVPAMWDPRAARTPPRELAVLLCNKSNAFYSLGKWDEAFLAAKECLQWDPTYVKGYYRAGYSLLHLLQPYEAARMFFEGLRLLQRSPDQVQVPDFLVGIFTTMSSDSIVLQSFLPCFDHIFSTGFSTEVWQSVIQKLAKKGLWHQSFLLLSAKKDRLPSNIHVSELSLQSLFEKYVFIGLYEKMEQVPKLVQWLISIGANIETIGPSPLHALMRLCIQSRESQLFRWVMEYKPEWKEHINYRDDAGCTVLHVAAAHFPGYTIKRQTEDVQMLLSFGADPTLLDGHARSAVDVLKRNRNFRAVDKINSHLEKLASSSKGRSEISAGLDVNRDCATTFVKFLLERQKWPEVLLLLTRKASGQHQLRNGLIKDCDLSDLDICTVIPHLSAWDQRKTQLLSRLIDSGALPEGLQDSQDRPLLMCLRHEDFDLAFLLLTKGADPRSVSLMEGDTPLHAALHIFLDINADIGFNFLSHLLDLFLSNPTEFYYLNPNVQDSNGNTLMHLLFQKGMLKRTKKLIELLVKFDINFNLKNKAGKGVRHRIKKNDALLLAWNKALTESRRKNRQDPAAHLGRLSRSSALGHTSQLKSQTSFKSLPCSTADRTLSKGVTEILPDVQVTRQEPEAMRTRSLRDRLVQDITVLIQQIELDMSLPQDYPQQGSPKMAAGMEGKKDKLQRTQSMGSSGSSRDNPVASEAGDGHAQAGPGALQLAPVGNRLRVAGGNQDNWTMQEIQACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHSKGNIQLFEAKLDKGARMLWELAIDFSARCSENSEKIMGTERNTYSMEKSGRVYTEIIRIWDIVLDHCKLSDSIMAICSAYTRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKSIEQADPEYFPPASAVETEYNIMKFHSFSTSMALNILNDMTATVEYPFRVGELEYAVIDLNPKPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLSKQILPKRRLEVEPGKEGPGQEEEENEEEEGSIKVETVDSTEEEQESEACAGGTVESAGDSQAAEGCVPDHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIVGWSTQEEFSIPSWEEDEDEVEADGNYSEEEKTTETQTGDSDPRVYVTFEVFTNEIWPKMIKGRSSYNPALIWKEIKSFLKGSFEALSCPHGRLTEEAYQKLGRKRSPNFKEDRSEIYSLFCLYQQIRSQKGYFDEEDVLYNLSWRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLLSLFHYASRNTVDKQCAVRKPKRIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTLLDSCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFIPSSDSREENCPLLDVPLEKSSSSQARSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENLEKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPDEWIIQGDYYAKHQCWKVAAKCYQKGDAFEKEKLALAHYTALNMKSKKFSPKEKELQYLELAKTYLECNEPKLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCFKDAFRCFEQIQEFDLALRMYCQEELFEEAAIAVEKYEEMLKNKTFPVPKLSYSASQFYLEAAAKYLSANKSKEMMAVLSKLDVEDQLVFLKSRKRLAEAAELLNREGRKEEAALLMKQHGCLLEAARLTANKDFQASCLLGVARLNVARDSDVEHTKAILREVLDLCYQTGHLAGIAEAQFLQGIILRDFQKLRDAFIKFDMLNHSAGMVEALYEAASQCESESQKVLALAPGGLEVLLNLVRALKNVTNNAEKEMVKSCFEFFGIFQVDAKYCQIAQNDPGPILRIILDLDLTLSEKKTKDHFLVLTDQVKLALNKHLLGRLCQITQILLGKTYPGICMRFIVGLKCEDEHCEDFHRPLRRCEAKCMVQSKMHLVAINGLLLEAKKVFPNVLAEELEEIDYILSPDTYGLCKSFLNLLFPRHFHQRVLSENPMACKEILKANYKFFRSYRFALKEYIHDLFQKESAHSRRESTDLWLSAMQAFLLSSSYPDEFEKLLHQEEDSYNRELKVLESDREDRGRGRGSRMKGIEGKFGMLVPNREDENVERSYLCFIRLLESSMDQLYVHRNPEDYKRLFFRFMNVLIKRCKAPLVPSIINTVVLLELQFVHCGAVLARLWKNAVLCLPKSYIALLHFWEFLSSKKDRESGDVFSIIQEYKPKDVTRAVRDFRFHLSYLVKVLCGYENMNFNVLLDSFSEIDYVISGEAERTLVLCLVMLVNAEEVLHPFCKPLLFRHFREIQKRLQLMSMDWPGQVPKRLQKVVQRVLMAVSVKSVAEALQDLLFERDEEYLVDCHWRWDSVHAKGTVVRGLCHEEVRLNRLLCTGPMDQFADSDWDFGEDETHELDELALEDRDNFLAAILSQKQRKALIQRKLRTACLVVSLCISWRRWIQTEHSREEDRELRPGNFKRADVDRTQCDLCGVKFARSPESYFSAGKAFEGAATEAVIISRAELEGRECRERVSESYEQHIRLEGHRRQQAAYQKYLDFFHEKVDPIIEEGKVVVQDVEQSVWIRSHLGSKEQSHMLQRKVQEHIRKVSDLVEELYRRKAWAEAEEVMTRQVKILTLSVKNAQEWLKKTELRLKDEGTVQDEEYENEVEDFGELCPRRRARKCGKQRKY", "length": 2999 }, "evidence": [ { "id": "A0AAA9SEL9", "url": "https://omabrowser.org/oma/group/A0AAA9SEL9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15050-1", "protein_name": "TPR and ankyrin repeat-containing protein 1", "gene_name": "TRANK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLKTKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPKILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILKPNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIESRLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLMDCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDYENEVEDFGELRPRRRSRKCGKQRKY", "length": 2925 }, "evidence": [ { "id": "A0AAA9SEL9", "url": "https://omabrowser.org/oma/group/A0AAA9SEL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BV79-1", "protein_name": "TPR and ankyrin repeat-containing protein 1", "gene_name": "Trank1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTTAGRRWPPRRRSSRRGPTPRSRAPGAKLSAPEAGPPRRGPLPRGGAGRDTLLGAKATPSSPAARRYVTALGPPQPRGSTDSACAALPQPVPHEPREAAFRLAPASERGASVSPARIPRRRRRVPAMWDPRAARTPPRELAMLLCNKSNAFYNLGKWNEAFLAAKECLQWDPTYVKGYYRAGYSLLHLLQPYEAARMFFEGLRLLQRSPDQLQVPDFLVGIFTTMSSDSIVLQSFLPCFDHIFTTGFSTEVWQYVIQKLAKKGLWHSFLLLSAKKDRLPSNIHVSELSLQSLFEKYVFIGFYEKLEQVPKLVQWLVSIGANIETIGPNPLHALMRLCIQARESQLFRWVMDQKPEWKEHINHRDDAGCTVLHVAAAHFPGYTSRRQTEDVQMLLSFGADPTLLDGHARTVVDVLKRNKNFRAIDKINSHLEKLASSSKGLSEIPAGLVCDVNRDCATTFIKFLLERQKWPEVLLLLTRKVSGQPQLRNGVIKDCDLSDLDICTVIPHLSSWDQRKTQLLSRLIDSGALPEGLQDSQDRPLLMCLRHEDFDLAFLLLTKGADPRSVSLVEGDTPLHAALHIFLDINADIGFNFLSHLLDLFLSNPTEFYYLNPNVQDSNGNTLMHLLFQKGMLKRTKKLIDLLVKFDINFNLKNKAGKGVRHRIKKNDALLLAWNKALTESRRKNRQDPAAHLGRLSRSSAPGHTSQLKSQTSFKSLPCGTADTTLSKGLTESLPDVQVSRQEPEAVRTRSLRDRLVQDITVLIQQVELGMPLPEDSPQRDSPKVAAGTEGKKDKLQRTQRMGSSGCSGNNPVASEAGDGAQAGPGASQLVPVGNRLGVASDNQENWTMQEIQACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHSKGNIQLFEAKLDKGARMLWELAIDFSARCSENSEKIIGTERNTYSLEKSGRVYTEIIRIWDIVLDHCKLSDSIMAICSAYTRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKSLEQVDPEYFPPASAVETEYSIMKFHSFSTNMALNILNDMTATVEYPFRVGELEYAVIDLNPKPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLSKQILPKRRLEVEPGKEGPGREEEEHEEEEGSIKVETVDGIDEEQESEACAGGATVEPAGDSQGAEGCVPDHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIVGWSTQEEFSIPSWEEDDEEVEADGNYNEEEKATETQTGDSDPRVYVTFEVFTNEIWPKMIKGRSSYNPALIWKEIKSFLKGSFEALSCPHGRLTEEAYKKLGRKRSPNFKEDRSEIYSLFCLYQQIRSQKGYFDEEDVLYNLSWRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLLSLFHYASRSTVDKQCAVRKPKRIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTLLDSCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEKAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSDSREEKWPLVDVPLERSSPSQARSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENLEKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPYEWIIQGDYYAKHQCWKVAAKCYQKGDALEKEKLALAHYTALNMKSKKFSPKEKELQYLELAKTYLECNEPKLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCFQDAFRCFEQIQEFDLALRMYCQEELFEEAAIAVEKYEEMLKNKTFPIPKLSYSASQFYLEAAAKYLSANKSKEMMAVLSKLDVEDQLVFLKSRKCLAEAAELLNREGRREEAALLMKQHGCLLEAARLTANKDFQASCLLGVARFNVARDSDIEHTKVILREALDLCYQTSQLAGIAEAQFLLGIILRDFQKLRDAFIKFDMLNHSAGMVEALYEAASLCESEHQKVLALAPGGLEVLLNLVRALKNVTNNAEKEMVKSCFEFFGIFQVDAKYCQIAQNDPGPILRIILDLDLTLSEKKTKDHFLIVTDQVKLALNKHLLGRLCQITQILLGKAYPGICMRFIVGLKCEDEQCEDFHRPLRRCEAKCMVQSKMHLVAINGLLLEAKKVFPNVLAEDLEEMDYILSPDTYGLCKSFLNLLFPRHFHQRVLSENPMACKDILKPNYKSFRSFRCALKEYIHDLFQKESAHSRRESTDLWLSAMQAFLLSSSYPEDFEKLLRQEEDSYNRELKVLESDREDRGRGRGSRVRGIEGKFGMLVPNREDENVEKSYLCFIRLLESSMDQLYVRRNPGDYKRLFFRFMNVLIKRCKAPLVPSIINTVVLLELQFVHCGVVLTRLWKNAVLCLPKSYIALLHFWEFLYGKKDRESGEVFSIIQEYKPKDVTRAIRDFRFHLSYLVKVLCGYENMNFNVLLDSFSEIDYVISGEAERTLVLCLVMLVNAEEVLQPFCKPLLFRHFREIQTRLQLMSMDWPGQVPKRLLKVVQRVLVAASVKSVAEALQDLLFERDEEYLVDCHWRWDSVHTKGTVVRGLCHEEVRLNRLLCTGPMDQFADSEWDFGEDETHELDELAQEDRDNFLAAILSQKQRKALIQRKLRRVCLVVSLCIRWRRWVQTEHSREDREVRPGNFKRADVDRTQCDLCGVKFTRSPESYFSPGKAFEGTATEAVLISRAELEGRECRERISESYEQHIRLEGHRRQQAAYQKYLDFFHEKVDPIIEEGKVVVQGIEQSVWIRSHLGSKEQSHMLQRKVQEHIRRVSDLVEELYRRKAWAEAEEVMTQQVKILTLSVKNAQEWLKKTELRLKDEGTVQEEEYENEVEDFGELRPRRRAQKCGKQRKH", "length": 2999 }, "evidence": [ { "id": "A0AAA9SEL9", "url": "https://omabrowser.org/oma/group/A0AAA9SEL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1065, "end_pos": 1067, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1444, "end_pos": 1446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1689, "end_pos": 1691, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1950, "end_pos": 1952, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2085, "end_pos": 2087, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" }, { "start_pos": 854, "end_pos": 856, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL9" }, { "id": "PS51198", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51198" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UvrD-like helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 1078, "end_pos": 1543, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1720 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1065, "end_pos": 1067 }, { "start_pos": 1444, "end_pos": 1446 }, { "start_pos": 1689, "end_pos": 1691 }, { "start_pos": 1950, "end_pos": 1952 }, { "start_pos": 2085, "end_pos": 2087 }, { "start_pos": 32, "end_pos": 34 }, { "start_pos": 555, "end_pos": 557 }, { "start_pos": 761, "end_pos": 763 }, { "start_pos": 83, "end_pos": 85 }, { "start_pos": 854, "end_pos": 856 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHU8-1", "uniprot_ac": "A0AAA9SHU8", "uniprot_id": "A0AAA9SHU8_BOVIN", "mass": { "chemical_mass": 96477.0, "monoisotopic_mass": 96477.0 }, "refseq": { "ac": "XP_010799754", "name": "ventricular zone-expressed PH domain-containing protein homolog 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799754" }, "gene_names": [ { "name": "VEPH1", "type": "recommended", "evidence": [ { "id": "A0AAA9SHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ] }, { "name": "VEPH1", "type": "synonym", "evidence": [ { "id": "XP_010799754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799754" } ] } ], "protein_names": [ { "name": "Ventricular zone expressed PH domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8/entry#names_and_taxonomy" } ] }, { "name": "ventricular zone-expressed PH domain-containing protein homolog 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010799754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799754" } ] } ], "function": [ { "annotation": "Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RUP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP2#function" }, { "database": "UniProtKB", "id": "ARBA00059998", "url": "https://www.uniprot.org/uniprotkb/ARBA00059998#function" }, { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8#function" }, { "database": "UniProtKB", "id": "A0AAA9SYH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYH9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VEPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8", "locus": { "chromosome": "1", "start_pos": 110343097, "end_pos": 110075675, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024643", "url": "https://www.ensembl.org/id/ENSBTAG00000024643" } ] } } ], "crossref": [ { "id": "A0AAA9SHU8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024643", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024643", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01264", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01264", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337421", "url": "https://www.ncbi.nlm.nih.gov/gene/100337421", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100337421", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337421", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WIRIMLL", "url": "https://omabrowser.org/oma/group/WIRIMLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MPJ3", "url": "https://www.orthodb.org/?gene=F1MPJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21630:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21630:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010799754", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799754", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPJ3", "url": "https://www.uniprot.org/uniprotkb/F1MPJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MPJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHGPGPAGSPLIIKPLSMHQLFRLVLGQKDLSRAGDLFSLEDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPSGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNAMLLRVLPAVYEKQPQPINRHLTELLGLMSQLEQPEQYHLLRLLHVAAKRKQLEVVQKCIPFLIGQLKDSTHNDIILSILIEIAGYKPMALNSFLPMLKEIAERSPYLIGQMARIYGAVGHVDEERARSCLPFLVSQLASMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAISKLLTRQLETTKARNDRRKPSTEIEFLEKLEETKLTVDENEDHEELQVKIQAFEDKINAEDNTPGSLRRYSLDQVSKEERKGIRFNRSKSLALHTVLTNSLSAEDGEAIESKDMPASISLSEIEPLGQGHEMSPFKVDTDGSQLGNSSVSHQSIIHVASENLPEAVKKNYQEETPETTTSPVEYHDKLYLHLKENFSKVKAYAVEMVKKIPVPDQCTIEDSVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQEGGAHSFETAMIESTFPQQKDLDQVQLHLEEVRFFDVFGFSEAAGAWQCFMCNNPERATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKVVAKKRRDRSLPRAFEIFTDNKTYVFKAKNEKNAEEWLQCINVAVAQAKERESREVTTYL", "length": 850, "header": "tr|A0AAA9SHU8-1|A0AAA9SHU8_BOVIN Isoform 1 of Ventricular zone expressed PH domain containing 1 OS=Bos taurus OX=9913 GN=VEPH1 PE=3 SV=1 CANONICAL=A0AAA9SHU8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8/entry#A0AAA9RUP2-1", "sequence": { "sequence": "MHGPGPAGSPLIIKPLSMHQLFRLVLGQKDLSRAGDLFSLEDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPSGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNAMLLRVLPAVYEKQPQPINRHLTELLGLMSQLEQPEQYHLLRLLHVAAKRKQLEVVQKCIPFLIGQLKDSTHNDIILSILIEIAGYKPMALNSFLPMLKEIAERSPYLIGQMARIYGAVGHVDEERARSCLPFLVSQLASMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAISKLLTRQLETTKARNDRRKPSTEIEFLEKLEETKLTVDENEDHEELQVKIQAFEDKINAEDNTPGSLRRYSLDQVSKEERKGIRFNRSKSLALHTVLTNSLSAEDGEAIESKDMPASISLSEIEPLGQGHEMSPFKVDTDGSQLGNSSVSHQSIIHVASENLPEAVKKNYQEETPETTTSPVEYHDKLYLHLKENFSKVKAYAVEMVKKIPVPDQCTIEDSVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQDLDQVQLHLEEVRFFDVFGFSEAAGAWQCFMCNNPERATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKVVAKKRRDRSLPRAFEIFTDNKTYVFKAKNEKNAEEWLQCINVAVAQAKERESREVTTYL", "length": 805, "header": "tr|A0AAA9RUP2-1|A0AAA9SHU8_BOVIN Computationally mapped isoform of Ventricular zone expressed PH domain containing 1 OS=Bos taurus OX=9913 GN=VEPH1 PE=3 SV=1 CANONICAL=A0AAA9SHU8-1" }, "locus": { "chromosome": "1", "start_pos": 110342093, "end_pos": 110075784, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102174.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102174.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074656.1" } ] } }, { "isoform_ac": "A0AAA9SHU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8/entry#A0AAA9SHU8-1", "sequence": { "sequence": "MHGPGPAGSPLIIKPLSMHQLFRLVLGQKDLSRAGDLFSLEDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPSGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNAMLLRVLPAVYEKQPQPINRHLTELLGLMSQLEQPEQYHLLRLLHVAAKRKQLEVVQKCIPFLIGQLKDSTHNDIILSILIEIAGYKPMALNSFLPMLKEIAERSPYLIGQMARIYGAVGHVDEERARSCLPFLVSQLASMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAISKLLTRQLETTKARNDRRKPSTEIEFLEKLEETKLTVDENEDHEELQVKIQAFEDKINAEDNTPGSLRRYSLDQVSKEERKGIRFNRSKSLALHTVLTNSLSAEDGEAIESKDMPASISLSEIEPLGQGHEMSPFKVDTDGSQLGNSSVSHQSIIHVASENLPEAVKKNYQEETPETTTSPVEYHDKLYLHLKENFSKVKAYAVEMVKKIPVPDQCTIEDSVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQEGGAHSFETAMIESTFPQQKDLDQVQLHLEEVRFFDVFGFSEAAGAWQCFMCNNPERATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKVVAKKRRDRSLPRAFEIFTDNKTYVFKAKNEKNAEEWLQCINVAVAQAKERESREVTTYL", "length": 850, "header": "tr|A0AAA9SHU8-1|A0AAA9SHU8_BOVIN Isoform 1 of Ventricular zone expressed PH domain containing 1 OS=Bos taurus OX=9913 GN=VEPH1 PE=3 SV=1 CANONICAL=A0AAA9SHU8-1" }, "locus": { "chromosome": "1", "start_pos": 110342093, "end_pos": 110075784, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089551.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089551.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085794.1" } ] } }, { "isoform_ac": "A0AAA9SYH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8/entry#A0AAA9SYH9-1", "sequence": { "sequence": "MWKAPSICGLQDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPSGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNAMLLRVLPAVYEKQPQPINRHLTELLGLMSQLEQPEQYHLLRLLHVAAKRKQLEVVQKCIPFLIGQLKDSTHNDIILSILIEIAGYKPMALNSFLPMLKEIAERSPYLIGQMARIYGAVGHVDEERARSCLPFLVSQLASMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAISKLLTRQLETTKARNDRRKPSTEIEFLEKLEETKLTVDENEDHEELQVKIQAFEDKINAEDNTPGSLRRYSLDQVSKEERKGIRFNRSKSLALHTVLTNSLSAEDGEAIESKDMPASISLSEIEPLGQGHEMSPFKVDTDGSQLGNSSVSHQSIIHVASENLPEAVKKNYQEETPETTTSPVEYHDKLYLHLKENFSKVKAYAVEMVKKIPVPDQCTIEDSVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQEGGAHSFETAMIESTFPQQKDLDQVQLHLEEVRFFDVFGFSEAAGAWQCFMCNNPERATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKVVAKKRRDRSLPRAFEIFTDNKTYVFKAKNEKNAEEWLQCINVAVAQAKERESREVTTYL", "length": 798, "header": "tr|A0AAA9SYH9-1|A0AAA9SYH9_BOVIN Computationally mapped isoform of Ventricular zone expressed PH domain containing 1 OS=Bos taurus OX=9913 GN=VEPH1 PE=3 SV=1 CANONICAL=A0AAA9SHU8-1" }, "locus": { "chromosome": "1", "start_pos": 110342093, "end_pos": 110113704, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095955.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095955.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089149.1" } ] } }, { "isoform_ac": "F1MPJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8/entry#F1MPJ3-1", "sequence": { "sequence": "MHGPGPAGSPLIIKPLSMHQLFRLVLGQKDLSRAGDLFSLEDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPSGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNAMLLRVLPAVYEKQPQPINRHLTELLGLMSQLEQPEQYHLLRLLHVAAKRKQLEVVQKCIPFLIGQLKDSTHNDIILSILIEIAGYKPMALNSFLPMLKEIAERSPYLIGQMARIYGAVGHVDEERARSCLPFLVSQLASMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAISKLLTRQLETTKARNDRRKPSTEIEFLEKLEETKLTVDENEDHEELQVKIQAFEDKINAEDNTPGSLRRYSLDQVSKEERKGIRFNRSKSLALHTVLTNSLSAEDGEAIESKDMPASISLSEIEPLGQGHEMSPFKVDTDGSQLGNSSVSHQSIIHVASENLPEAVKKNYQEETPETTTSPVEYHDKLYLHLKENFSKVKAYAVEMVKKIPVPDQCTIEDSVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQEGGAHSFETAMIESTFPQQKDLDQVQLHLEEVRFFDVFGFSEAAGAWQCFMCNNPERATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSHHLLKRLSVSHCIFLPPLLKIN", "length": 794, "header": "tr|F1MPJ3-1|A0AAA9SHU8_BOVIN Computationally mapped isoform of Ventricular zone expressed PH domain containing 1 OS=Bos taurus OX=9913 GN=VEPH1 PE=3 SV=4 CANONICAL=A0AAA9SHU8-1" }, "locus": { "chromosome": "1", "start_pos": 110340931, "end_pos": 110075784, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034317.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034317.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034214.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034214.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100337421", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337421", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QVZ8-1", "protein_name": "Ventricular zone expressed PH domain containing 1", "gene_name": "VEPH1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHHLRPSGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPVAVKFLHRGNKELCRNMSNYLSLAAITKADLLVDHTEVIVKSILQGNATLLRVLPAVYDKQPQPINKHLTELLALMYQLEQPEQYHLLRLLHVAAKRKQLEVVQKCIPFLIGHLKNSMHNDVILSILIEIAGYEPVALNSFLPVLKEIGERFPYLIGQMARIYGTVGRVDEERARSCLPFLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLETAMARSDRRKTSNEIEFLEELEETKFTVDENEDHEKLQVKIQAFEDKITAENNTPGSIRRYSLDQVSKEGRKDIRFNRSKSLALHTVLTSALSSEDGDAVESADTPASISLSEIDPLGQGRDRSPFKADADGSQLVNSSVSHPSIMHIESENLPEMVKENHQEETPETTTSSVEYHDKLYLYLKENLSKVKAYALEIRKKIPVPDQCTIEDSVQSCVAKLFFSCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQDLDQVQLHLEEVRFFDVFGFSEAAGAWQCFMCNNPERATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKVVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREITTYL", "length": 788 }, "evidence": [ { "id": "A0AAA9SHU8", "url": "https://omabrowser.org/oma/group/A0AAA9SHU8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M2P6-1", "protein_name": "Protein melted homolog", "gene_name": "Veph1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHQLFRLVLGQKDLSRAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGNKELCRNMSNYLSLAAITKADVLADHTEGIIKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCIPFLIRHLKESTHNDFILNILIEIAGYEPLTLSGFLPMLKEIGERFPYLTGQIARIFGAVGHADEERARSCLRYLISQLANMEHSFHHILLLEIKSITDTFSSILGPHSRDIFRMSNSFTNIAKLLSRHLENGKAGNGRRKTSTEVGVPEKVGGAKTKEPESEDHEKLQVKIQAFEDKINSESNTPASVRRNSLDHVSKEEQRNIRFSRSRSLALNTVLTTGMRAEDEDAEERAGVHASISLSEIDPLIHGIGKLPLKIDTHGSQLRNSSASHPSIIHREPENMPKTVKENIQEEIPETATSPVEYQDKLYLHLKENFSKVKAYAMEITKKVPVPDQCTIEETMRSCVAKLFFTCSLKGHYCLYSKSSFTLISQAPQPWIQIMFLFQQSLFPEPLSIQNGSVQFLKGLWEKTQASGTHSFEDAMTESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL", "length": 833 }, "evidence": [ { "id": "A0AAA9SHU8", "url": "https://omabrowser.org/oma/group/A0AAA9SHU8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1A535-1", "protein_name": "Ventricular zone-expressed PH domain-containing protein 1", "gene_name": "Veph1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHQLFRLVLGQKDLSKAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIIKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKDSTYNDIILNILIEIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHPFHHILLLEIKSITDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLENSKADSSRRKTSTEVSIPEKLRELNSMEPESEDHEKLQVKIQAFEDKINAESNTPGSGRRYSLDHISKEERKSIRFSRSRSLALNTVLTNGVSVEDNEVEEKAGMHASISLSQIDPLSHGIGKLPFKTDTHGSPLRNSSASHPSIIHTEPETMPETFKENIQEEILEAATSPIEYQDKLYLHLRENLSKVKAYALEIAKKVPIPDQCTIEDTMRSCVAKLFFTCSLKGHYCLYSKSSFILVSQAPQPWIQVMFLSQQSLFPEPLSIQSGSVQFLKALWEKTQDTGAHSFEVAMTESTFPQQKDLEQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTHYFTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDSKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL", "length": 833 }, "evidence": [ { "id": "A0AAA9SHU8", "url": "https://omabrowser.org/oma/group/A0AAA9SHU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q14D04-1", "protein_name": "Ventricular zone-expressed PH domain-containing protein homolog 1", "gene_name": "VEPH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL", "length": 833 }, "evidence": [ { "id": "A0AAA9SHU8", "url": "https://omabrowser.org/oma/group/A0AAA9SHU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5PQS3-1", "protein_name": "Ventricular zone-expressed PH domain-containing protein homolog 1", "gene_name": "Veph1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHQLFRLVLGQKDLSRAGDLFSLDDAEIEDSLTEALEQIKVISSSLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDEDTPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKADLLADHTEGIVKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHLLRLLHVAAKRKDVEVVQKCVPFLIRNLKESTYNDIILNILIEIAGHEPLALNSFLPMLKEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHSFHHILLLEIKSLTDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLENSKAESGRRRTGTEVSFPEKFREPKTMEPKSEDHEKLQVKIQAFEDKINAESHTPGSVRRYSLDHVSKEERKNVRFSRSRSLALNTVLTNSVNVEDGEIEGKTGMHASISLSEIDPPGHGIGKVPFKTDTHGSQLRNSSASHPSIIHSEPENMPETFKENVQEEIPEAAISPVEYQDKLYLHLKENLSKVKAYALEIAKKVPIPDQCTIEDNTRSCVAKLFFTCSLKGHYCLYSKSSFTLVSQAPQPWIQIMFLFQQSLFPEPLSIQSGSVQFLKALWEKTQGTGTHSFEVAMTESTFPQQKDLDQLQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVINQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVALAQAKERESREVTTYL", "length": 832 }, "evidence": [ { "id": "A0AAA9SHU8", "url": "https://omabrowser.org/oma/group/A0AAA9SHU8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VS24-3", "protein_name": "Protein melted", "gene_name": "melt", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSSGGESIDVNQIRSVKVSRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKTNSLPARSIGSSKPSF", "length": 994 }, "evidence": [ { "id": "A0AAA9SHU8", "url": "https://omabrowser.org/oma/group/A0AAA9SHU8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ], "pmid": "" }, { "name": "negative regulation of SMAD protein signal transduction", "id": "GO:0060392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060392", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 733, "end_pos": 836, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 462, "end_pos": 464 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 571, "end_pos": 573 }, { "start_pos": 811, "end_pos": 813 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFJ0-1", "uniprot_ac": "A0AAA9SFJ0", "uniprot_id": "A0AAA9SFJ0_BOVIN", "mass": { "chemical_mass": 74445.0, "monoisotopic_mass": 74445.0 }, "refseq": { "ac": "XP_005219475", "name": "zinc finger protein 283 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219475" }, "gene_names": [ { "name": "ZNF283", "type": "recommended", "evidence": [ { "id": "A0AAA9SFJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ] }, { "name": "ZNF283", "type": "synonym", "evidence": [ { "id": "XP_005219475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219475" } ] } ], "protein_names": [ { "name": "Zinc finger protein 283", "type": "synonym", "evidence": [ { "id": "A0AAA9SFJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 283 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005219475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219475" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF283", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0", "locus": { "chromosome": "18", "start_pos": 52054228, "end_pos": 52039966, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012522", "url": "https://www.ensembl.org/id/ENSBTAG00000012522" } ] } } ], "crossref": [ { "id": "A0AAA9SFJ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFJ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012522", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012522", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517970", "url": "https://www.ncbi.nlm.nih.gov/gene/517970", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517970", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517970", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BLR3", "url": "https://www.orthodb.org/?gene=E1BLR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005219475", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1N8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1N8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1N8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1N8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLR3", "url": "https://www.uniprot.org/uniprotkb/E1BLR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLR3-1", "url": "https://www.uniprot.org/uniprotkb/E1BLR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSCSGFSGLCASPIEELYGALISSWDSRTMTDGMVTFRDVAIDFSQEEWEFLDPAQRDLYVDVMLENYSNLVSLDLESTYETKNTLSKKDIFEINFSQWKIKERSKTIELEASIFKNNWKCKSRFKGLQGHQERLFSQVIISYEKMPTYKKHESLIAHQRTPNQEKPYICKECGKAYRHGSKLVQHERIHMAKKHFECKECGKDFLSAYQLTVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHIGVKSYECKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHHKIHTGKKPYVCKICGRGFCWGYQLTRHQIFHTGKKPYECKECGKTFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHSGEKSYECKECGKTFGSGYQLTRHQIFHTGEKPYKCKACGKAFNCGSSLVQHERIHTGEKPYECKECGKTFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTGEKYYECRDCGKVFNSDYQLSVHQRFHTGEKPYQCKEFGKTFTCGVSHVQHERISNNDKPYKYKEYGEAFIWTAYSNGAVDAGETL", "length": 643, "header": "tr|A0AAA9SFJ0-1|A0AAA9SFJ0_BOVIN Isoform 1 of Zinc finger protein 283 OS=Bos taurus OX=9913 GN=ZNF283 PE=3 SV=1 CANONICAL=A0AAA9SFJ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0/entry#A0AAA9RUZ1-1", "sequence": { "sequence": "MENLDSESVSLCYSYKMLRSCSGFSGLCASPIEELYGALISSWDSRTMTDGMVTFRDVAIDFSQEEWEFLDPAQRDLYVDVMLENYSNLVSLDLESTYETKNTLSKKDIFEINFSQWKIKERSKTIELEASIFKNNWKCKSRFKGLQGHQERLFSQVIISYEKMPTYKKHESLIAHQRTPNQEKPYICKECGKAYRHGSKLVQHERIHMAKKHFECKECGKDFLSAYQLTVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHIGVKSYECKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHHKIHTGKKPYVCKICGRGFCWGYQLTRHQIFHTGKKPYECKECGKTFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHSGEKSYECKECGKTFGSGYQLTRHQIFHTGEKPYKCKACGKAFNCGSSLVQHERIHTGEKPYECKECGKTFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTGEKYYECRDCGKVFNSDYQLSVHQRFHTGEKPYQCKEFGKTFTCGVSHVQHERISNNDKPYKYKEYGEAFIWTAYSNGAVDAGETL", "length": 659, "header": "tr|A0AAA9RUZ1-1|A0AAA9SFJ0_BOVIN Computationally mapped isoform of Zinc finger protein 283 OS=Bos taurus OX=9913 GN=ZNF283 PE=3 SV=1 CANONICAL=A0AAA9SFJ0-1" }, "locus": { "chromosome": "18", "start_pos": 52053224, "end_pos": 52040333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130000.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130000.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074786.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074786.1" } ] } }, { "isoform_ac": "A0AAA9S1N8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0/entry#A0AAA9S1N8-1", "sequence": { "sequence": "SGFSGLCASPIEELYGALISSWDSRTMTDGMVTFRDVAIDFSQEEWEFLDPAQRDLYVDVMLENYSNLVSLDLESTYETKNTLSKKDIFEINFSQWKIKERSKTIELEASIFKNNWKCKSRFKGLQGHQERLFSQVIISYEKMPTYKKHESLIAHQRTPNQEKPYICKECGKAYRHGSKLVQHERIHMAKKHFECKECGKDFLSAYQLTVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHIGVKSYECKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHHKIHTGKKPYVCKICGRGFCWGYQLTRHQIFHTGKKPYECKECGKTFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHSGEKSYECKECGKTFGSGYQLTRHQIFHTGEKPYKCKACGKAFNCGSSLVQHERIHTGEKPYECKECGKTFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTGEKYYECRDCGKVFNSDYQLSVHQRFHTGEKPYQCKEFGKTFTCGVSHVQHERISNNDKPYKYKEYGEAFIWTAYSNGAVDAGETL", "length": 638, "header": "tr|A0AAA9S1N8-1|A0AAA9SFJ0_BOVIN Computationally mapped isoform of Zinc finger protein 283 OS=Bos taurus OX=9913 GN=ZNF283 PE=3 SV=1 CANONICAL=A0AAA9SFJ0-1" }, "locus": { "chromosome": "18", "start_pos": 52053224, "end_pos": 52042264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133409.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133409.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077224.1" } ] } }, { "isoform_ac": "A0AAA9SFJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0/entry#A0AAA9SFJ0-1", "sequence": { "sequence": "MLRSCSGFSGLCASPIEELYGALISSWDSRTMTDGMVTFRDVAIDFSQEEWEFLDPAQRDLYVDVMLENYSNLVSLDLESTYETKNTLSKKDIFEINFSQWKIKERSKTIELEASIFKNNWKCKSRFKGLQGHQERLFSQVIISYEKMPTYKKHESLIAHQRTPNQEKPYICKECGKAYRHGSKLVQHERIHMAKKHFECKECGKDFLSAYQLTVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHIGVKSYECKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHHKIHTGKKPYVCKICGRGFCWGYQLTRHQIFHTGKKPYECKECGKTFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHSGEKSYECKECGKTFGSGYQLTRHQIFHTGEKPYKCKACGKAFNCGSSLVQHERIHTGEKPYECKECGKTFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTGEKYYECRDCGKVFNSDYQLSVHQRFHTGEKPYQCKEFGKTFTCGVSHVQHERISNNDKPYKYKEYGEAFIWTAYSNGAVDAGETL", "length": 643, "header": "tr|A0AAA9SFJ0-1|A0AAA9SFJ0_BOVIN Isoform 1 of Zinc finger protein 283 OS=Bos taurus OX=9913 GN=ZNF283 PE=3 SV=1 CANONICAL=A0AAA9SFJ0-1" }, "locus": { "chromosome": "18", "start_pos": 52053224, "end_pos": 52041601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102966.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102966.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082638.1" } ] } }, { "isoform_ac": "A0AAA9TZ64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0/entry#A0AAA9TZ64-1", "sequence": { "sequence": "MLRSCSGFSGLCASPIEELYGALISSWDSRTMTDIWSRHMRQKIHYQKRTFLK", "length": 53, "header": "tr|A0AAA9TZ64-1|A0AAA9TZ64_BOVIN Computationally mapped isoform of Zinc finger protein 283 OS=Bos taurus OX=9913 GN=ZNF283 PE=4 SV=1 CANONICAL=A0AAA9SFJ0-1" }, "locus": { "chromosome": "18", "start_pos": 52051581, "end_pos": 52041601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130796.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130796.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102003.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102003.1" } ] } }, { "isoform_ac": "E1BLR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0/entry#E1BLR3-1", "sequence": { "sequence": "MTDGMVTFRDVAIDFSQEEWEFLDPAQRDLYVDVMLENYSNLVSLDLESTYETKNTLSKKDIFEINFSQWKIKERSKTIELEASIFKNNWKCKSRFKGLQGHQERLFSQDFLSAYQLTVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHIGVKSYECKECGKAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHHKIHTGKKPYVCKICGRGFCWGYQLTRHQIFHTGKKPYECKECGKTFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHSGEKSYECKECGKTFGSGYQLTRHQIFHTGEKPYKCKACGKAFNCGSSLVQHERIHTGEKPYECKECGKTFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLVKHERVHTGEKYYECRDCGKVFNSDYQLSVHQRFHTGEKPY", "length": 494, "header": "tr|E1BLR3-1|A0AAA9SFJ0_BOVIN Computationally mapped isoform of Zinc finger protein 283 OS=Bos taurus OX=9913 GN=ZNF283 PE=3 SV=4 CANONICAL=A0AAA9SFJ0-1" }, "locus": { "chromosome": "18", "start_pos": 52053065, "end_pos": 52042342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012076.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012076.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012076.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012076.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517970", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517970", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 170, "end_pos": 197, "start_aa": "Tyr", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFJ0" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 113, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 69, "end_pos": 71 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFN9-1", "uniprot_ac": "A0AAA9SFN9", "uniprot_id": "A0AAA9SFN9_BOVIN", "mass": { "chemical_mass": 76818.0, "monoisotopic_mass": 76818.0 }, "refseq": {}, "gene_names": [ { "name": "BBS2", "type": "recommended", "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ] } ], "protein_names": [ { "name": "Bardet-Biedl syndrome 2 protein homolog", "type": "recommended", "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9#function" }, { "database": "UniProtKB", "id": "ARBA00060342", "url": "https://www.uniprot.org/uniprotkb/ARBA00060342#function" }, { "database": "UniProtKB", "id": "F1MU26", "url": "https://www.uniprot.org/uniprotkb/F1MU26#function" }, { "database": "UniProtKB", "id": "A0AAA9TT68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BBS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9", "locus": { "chromosome": "18", "start_pos": 24157746, "end_pos": 24056405, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014923", "url": "https://www.ensembl.org/id/ENSBTAG00000014923" } ] } } ], "crossref": [ { "id": "A0AAA9SFN9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014923", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014923", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MU26", "url": "https://www.orthodb.org/?gene=F1MU26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32465:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32465:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14783", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23350", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23350", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23353", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23353", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RXG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU26", "url": "https://www.uniprot.org/uniprotkb/F1MU26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU26-1", "url": "https://www.uniprot.org/uniprotkb/F1MU26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVFIHNPHSRSQHLGAPRVLQSPLESDVSLLNINQTVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREATDGASAIVLGTLGDITSPLAIIGGNCALQGFNHEGNDLFWTVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETEIITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRGSSSEGARK", "length": 695, "header": "tr|A0AAA9SFN9-1|A0AAA9SFN9_BOVIN Isoform 1 of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=1 CANONICAL=A0AAA9SFN9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#A0AAA9RXG3-1", "sequence": { "sequence": "MLQPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVADGASAIVLGTLGDITSPLAIIGGNCALQGFNHEGNDLFWTVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETEIITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRVGKPKNQVITACRDAIRSNNINMLFRIMRVGTASS", "length": 645, "header": "tr|A0AAA9RXG3-1|A0AAA9SFN9_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=1 CANONICAL=A0AAA9SFN9-1" }, "locus": { "chromosome": "18", "start_pos": 24147884, "end_pos": 24122414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122888.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122888.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078198.1" } ] } }, { "isoform_ac": "A0AAA9SFN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#A0AAA9SFN9-1", "sequence": { "sequence": "MLQPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVFIHNPHSRSQHLGAPRVLQSPLESDVSLLNINQTVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREATDGASAIVLGTLGDITSPLAIIGGNCALQGFNHEGNDLFWTVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETEIITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRGSSSEGARK", "length": 695, "header": "tr|A0AAA9SFN9-1|A0AAA9SFN9_BOVIN Isoform 1 of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=1 CANONICAL=A0AAA9SFN9-1" }, "locus": { "chromosome": "18", "start_pos": 24157609, "end_pos": 24122414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115811.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115811.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081279.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081279.1" } ] } }, { "isoform_ac": "A0AAA9SQW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#A0AAA9SQW6-1", "sequence": { "sequence": "MLQPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVFIHNPHSRSQHLGAPRVLQSPLESDVSLLNINQTVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREVADGASAIVLGTLGDITSPLAIIGGNCALQGFNHEGNDLFWTVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETESKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRVGKPKNQVITACRDAIRSNNINMLFRIMRVGTASS", "length": 686, "header": "tr|A0AAA9SQW6-1|A0AAA9SQW6_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=1 CANONICAL=A0AAA9SFN9-1" }, "locus": { "chromosome": "18", "start_pos": 24147884, "end_pos": 24122414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096129.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096129.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085350.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085350.1" } ] } }, { "isoform_ac": "A0AAA9TQQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#A0AAA9TQQ6-1", "sequence": { "sequence": "MLQPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVFIHNPHSRSQHLGAPRVLQSPLESDVSLLNINQTVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETEIITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRVGKPKNQVITACRDAIRSNNINMLFRIMRVGTASS", "length": 679, "header": "tr|A0AAA9TQQ6-1|A0AAA9TQQ6_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=1 CANONICAL=A0AAA9SFN9-1" }, "locus": { "chromosome": "18", "start_pos": 24147884, "end_pos": 24122414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134665.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134665.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099344.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099344.1" } ] } }, { "isoform_ac": "A0AAA9TT68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#A0AAA9TT68-1", "sequence": { "sequence": "MLQPVFTLKLRHKISPRMVAVGRYDGTHPCLAAATQAGKVFIHNPHSRSQHLGAPRVLQSPLESDVSLLNINQTVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREVADGASAIVLGTLGDITSPLAIIGGNCALQGFNHEGNDLFWTVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETEIITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRVGKPKNQVITACRDAIRSNNINMLFRIMRVGTASS", "length": 675, "header": "tr|A0AAA9TT68-1|A0AAA9TT68_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=1 CANONICAL=A0AAA9SFN9-1" }, "locus": { "chromosome": "18", "start_pos": 24147884, "end_pos": 24122414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097996.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097996.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100263.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100263.1" } ] } }, { "isoform_ac": "F1MU26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9/entry#F1MU26-1", "sequence": { "sequence": "MGVFKVFIHNPHSRSQHLGAPRVLQSPLESDVSLLNINQTVSCLTAGVLNPELGYDALLVGTQTNLLAYDVYNNSDLFYREATDGASAIVLGTLGDITSPLAIIGGNCALQGFNHEGNDLFWTVTGDNVHSLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMSETEIITSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNQAMSIHAFDLNSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAIAGVVEGDYRMEGCQQLICCSVDGEIRGYLPGTAEMRGNLMDISVEQDLIRELSQKKQNLLLELRNYEENAKAELSSPLNEADGHRGVIPANTKLHTALSVSLGSEAQAAHAELCISTSNDTIIRAVLIFAEGVFAGESHVVHPSVHHLSSSVRIPITPPKDIPVDLHLKTFVGYRSSTQFHVFELTRQLPRFSMYALTSPDPASEPLSYVNFIIAERAQRVVMWLNQNFLLPEDTNIQNAPFQVCFTSLRNGGQLYIKIKLSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLVKVDEYHSVHQKLSADMADNSNLIRSLLVQAEDARLMRDMKTMKNRYMELYDLNKDLLNGYKIRCNNHTELLGSLKAVNQAIQRAGHLRVGKPKNQVITACRDAIRSNNINMLFRIMRVGTASS", "length": 687, "header": "tr|F1MU26-1|F1MU26_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 2 protein homolog OS=Bos taurus OX=9913 GN=BBS2 PE=4 SV=2 CANONICAL=A0AAA9SFN9-1" }, "locus": { "chromosome": "18", "start_pos": 24147884, "end_pos": 24128816, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032389.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032389.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032322.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032322.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 446, "start_aa": "Thr", "end_pos": 446, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr446", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "BBSome", "id": "GO:0034464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "negative regulation of appetite by leptin-mediated signaling pathway", "id": "GO:0038108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "regulation of cilium beat frequency involved in ciliary motility", "id": "GO:0060296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" }, { "id": "PF14782", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14782" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS2 GAE", "eco_id": "ECO_0000259", "start_pos": 396, "end_pos": 481, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" }, { "id": "PF23353", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23353" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS2 hairpin", "eco_id": "ECO_0000259", "start_pos": 587, "end_pos": 683, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" }, { "id": "PF23350", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23350" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS2 platform", "eco_id": "ECO_0000259", "start_pos": 484, "end_pos": 575, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" }, { "id": "PF14781", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14781" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ciliary BBSome complex subunit 2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 126, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN9" }, { "id": "PF14783", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14783" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ciliary BBSome complex subunit 2 middle region", "eco_id": "ECO_0000259", "start_pos": 165, "end_pos": 272, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 446 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 223, "end_pos": 225 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 664, "end_pos": 666 }, { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGQ1-1", "uniprot_ac": "A0AAA9SGQ1", "uniprot_id": "A0AAA9SGQ1_BOVIN", "mass": { "chemical_mass": 99345.0, "monoisotopic_mass": 99345.0 }, "refseq": { "ac": "XP_010800209", "name": "rap guanine nucleotide exchange factor 4 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800209" }, "gene_names": [ { "name": "RAPGEF4", "type": "recommended", "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ] }, { "name": "RAPGEF4", "type": "synonym", "evidence": [ { "id": "XP_010800209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800209" } ] } ], "protein_names": [ { "name": "Rap guanine nucleotide exchange factor 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#names_and_taxonomy" } ] }, { "name": "Exchange factor directly activated by cAMP 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#names_and_taxonomy" } ] }, { "name": "Exchange protein directly activated by cAMP 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#names_and_taxonomy" } ] }, { "name": "cAMP-regulated guanine nucleotide exchange factor II", "type": "synonym", "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#names_and_taxonomy" } ] }, { "name": "rap guanine nucleotide exchange factor 4 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010800209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800209" } ] } ], "function": [ { "annotation": "Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Does not seem to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG7#function" }, { "database": "UniProtKB", "id": "ARBA00094464", "url": "https://www.uniprot.org/uniprotkb/ARBA00094464#function" }, { "database": "UniProtKB", "id": "A0AAA9RY52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY52#function" }, { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1#function" }, { "database": "UniProtKB", "id": "A0AAA9T1V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V7#function" }, { "database": "UniProtKB", "id": "E1BPX7", "url": "https://www.uniprot.org/uniprotkb/E1BPX7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAPGEF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1", "locus": { "chromosome": "2", "start_pos": 23607682, "end_pos": 23937906, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020984", "url": "https://www.ensembl.org/id/ENSBTAG00000020984" } ] } } ], "crossref": [ { "id": "A0AAA9SGQ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020984", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020984", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00155", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04437", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04437", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537312", "url": "https://www.ncbi.nlm.nih.gov/gene/537312", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537312", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537312", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVRLCCV", "url": "https://omabrowser.org/oma/group/CVRLCCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPX7", "url": "https://www.orthodb.org/?gene=E1BPX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113:SF175", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF175", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00617", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00617", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00618", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00618", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-354192", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381676", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-392517", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392517", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-422356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010800209", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800209", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RY52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPX7", "url": "https://www.uniprot.org/uniprotkb/E1BPX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPX7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 867, "header": "tr|A0AAA9SGQ1-1|A0AAA9SGQ1_BOVIN Isoform 1 of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=1 CANONICAL=A0AAA9SGQ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#A0AAA9RY52-1", "sequence": { "sequence": "MRKRRAKWIASSRRGSSEPQYWGQKDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 937, "header": "tr|A0AAA9RY52-1|A0AAA9SGQ1_BOVIN Computationally mapped isoform of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=1 CANONICAL=A0AAA9SGQ1-1" }, "locus": { "chromosome": "2", "start_pos": 23860288, "end_pos": 23608938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103949.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103949.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076169.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076169.1" } ] } }, { "isoform_ac": "A0AAA9SGQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#A0AAA9SGQ1-1", "sequence": { "sequence": "MPCKKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 867, "header": "tr|A0AAA9SGQ1-1|A0AAA9SGQ1_BOVIN Isoform 1 of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=1 CANONICAL=A0AAA9SGQ1-1" }, "locus": { "chromosome": "2", "start_pos": 23848345, "end_pos": 23608938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092133.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092133.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085364.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085364.1" } ] } }, { "isoform_ac": "A0AAA9SRG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#A0AAA9SRG7-1", "sequence": { "sequence": "MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQGLQTLRTSLFLGMNPTSIQSNKYVDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 1035, "header": "tr|A0AAA9SRG7-1|A0AAA9SRG7_BOVIN Computationally mapped isoform of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=1 CANONICAL=A0AAA9SGQ1-1" }, "locus": { "chromosome": "2", "start_pos": 23937801, "end_pos": 23608938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101996.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101996.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086569.1" } ] } }, { "isoform_ac": "A0AAA9SU06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#A0AAA9SU06-1", "sequence": { "sequence": "MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 943, "header": "tr|A0AAA9SU06-1|A0AAA9SU06_BOVIN Computationally mapped isoform of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=1 CANONICAL=A0AAA9SGQ1-1" }, "locus": { "chromosome": "2", "start_pos": 23937801, "end_pos": 23608938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120342.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120342.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087489.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087489.1" } ] } }, { "isoform_ac": "A0AAA9T1V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#A0AAA9T1V7-1", "sequence": { "sequence": "MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 1011, "header": "tr|A0AAA9T1V7-1|A0AAA9T1V7_BOVIN Computationally mapped isoform of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=1 CANONICAL=A0AAA9SGQ1-1" }, "locus": { "chromosome": "2", "start_pos": 23937801, "end_pos": 23608938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114465.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114465.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090391.1" } ] } }, { "isoform_ac": "E1BPX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1/entry#E1BPX7-1", "sequence": { "sequence": "MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 993, "header": "tr|E1BPX7-1|A0AAA9SGQ1_BOVIN Computationally mapped isoform of Rap guanine nucleotide exchange factor 4 OS=Bos taurus OX=9913 GN=RAPGEF4 PE=4 SV=4 CANONICAL=A0AAA9SGQ1-1" }, "locus": { "chromosome": "2", "start_pos": 23937801, "end_pos": 23608938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061074.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061074.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053320.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053320.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 617, "start_aa": "Thr", "end_pos": 617, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr617", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:537312", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537312", "resource": "KEGG Pathway" }, { "id": "R-BTA-354192", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-354192", "resource": "Reactome", "description": "Integrin signaling" }, { "id": "R-BTA-381676", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "resource": "Reactome", "description": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion" }, { "id": "R-BTA-392517", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-392517", "resource": "Reactome", "description": "Rap1 signalling" }, { "id": "R-BTA-422356", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422356", "resource": "Reactome", "description": "Regulation of insulin secretion" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZKI7-1", "protein_name": "Rap guanine nucleotide exchange factor 4", "gene_name": "RAPGEF4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVAAHTSHSASSGEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLQQICLCGYYENLEKGITLFRQGDIGSNWYAVLTGSLDVKVSDTSNHQDAVTICTLGIGTAFGESILDNTPRHATIVTREYSELLRIEQKDFKALWEKYRQYMSGLLTPPYGVMETGSNNDRMPDKDSMSSGALCQVSKNCNKVPSEKILRAGKILRNTILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQSTCVHSRSQAVGMWQVLLEEGVLNHVDQEHHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQIGPDAHMRMILRKPPGQRSIDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHPKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKIPAGNRVSNQGSSQPQHKYIVMSGTPEKILEHFLETMRLEATLNEATDSVLNDFIMMHCVFMPNSQLCPALMAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAALYGDLLQEDEAAMAFLEEFYVSVSDDTRMIAALKEQLPELEKIVKQVAEEPKAPQKKHKVLLQLFNTSDDRAQKRQPIRGSDEVLFKVYCIDQTYTTIRVPVSSSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPHDVSVFTTLSVNGRLFACPRDQFDSLAPLPEQEGPSAGTVGTFELMSSKDLAHQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKYIKIAAHCKEYKNLNSFFAIIMGLSNVAVSRLSLTWEKLPSKFKKIYAEFESLMDPSRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTHEGNKTLTDNLVNFEKMRMIANTVRTVKFCRSQSFNPDAALANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRA", "length": 1008 }, "evidence": [ { "id": "A0AAA9SGQ1", "url": "https://omabrowser.org/oma/group/A0AAA9SGQ1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1Z6P8-1", "protein_name": "Exchange protein directly activated by cAMP, isoform E", "gene_name": "Epac", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL", "length": 1006 }, "evidence": [ { "id": "A0AAA9SGQ1", "url": "https://omabrowser.org/oma/group/A0AAA9SGQ1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8WZA2-1", "protein_name": "Rap guanine nucleotide exchange factor 4", "gene_name": "RAPGEF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 1011 }, "evidence": [ { "id": "A0AAA9SGQ1", "url": "https://omabrowser.org/oma/group/A0AAA9SGQ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9EQZ6-1", "protein_name": "Rap guanine nucleotide exchange factor 4", "gene_name": "Rapgef4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP", "length": 1011 }, "evidence": [ { "id": "A0AAA9SGQ1", "url": "https://omabrowser.org/oma/group/A0AAA9SGQ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "hippocampal mossy fiber to CA3 synapse", "id": "GO:0098686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098686", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "regulation of insulin secretion", "id": "GO:0050796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle cycle", "id": "GO:0098693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "Rap protein signal transduction", "id": "GO:0032486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032486", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "cAMP binding", "id": "GO:0030552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 794, "end_pos": 796, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 313, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 147, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" }, { "id": "PS50212", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50212" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "N-terminal Ras-GEF", "eco_id": "ECO_0000259", "start_pos": 352, "end_pos": 490, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ1" }, { "id": "PS50009", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50009" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-GEF", "eco_id": "ECO_0000259", "start_pos": 628, "end_pos": 865, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 617 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 794, "end_pos": 796 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFZ5-1", "uniprot_ac": "A0AAA9SFZ5", "uniprot_id": "A0AAA9SFZ5_BOVIN", "mass": { "chemical_mass": 85555.0, "monoisotopic_mass": 85555.0 }, "refseq": {}, "gene_names": [ { "name": "MAP7D2", "type": "recommended", "evidence": [ { "id": "A0AAA9SFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ] } ], "protein_names": [ { "name": "MAP7 domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAP7D2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5", "locus": { "chromosome": "X", "start_pos": 123179010, "end_pos": 123081004, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017628", "url": "https://www.ensembl.org/id/ENSBTAG00000017628" } ] } } ], "crossref": [ { "id": "A0AAA9SFZ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017628", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017628", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "107131180", "url": "https://www.ncbi.nlm.nih.gov/gene/107131180", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BF55", "url": "https://www.orthodb.org/?gene=E1BF55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15073:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15073:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05672", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05672", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RY56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLV5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLV5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF55", "url": "https://www.uniprot.org/uniprotkb/E1BF55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF55-1", "url": "https://www.uniprot.org/uniprotkb/E1BF55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHGVGYAAATAGTEGATRAPPLPGKMAEPGAVRTSPPNHRPSGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWKKLEEQRQREEQKRAAVEEKRKQKLREEEERLEAMMRRSLERSQQLELKKKCSSGGASLAAGPGGRDACDKLSTSTMNLPKQTEPPMSKRLSSSTAAISYSPDRAHRMHLSPMETFLVMRLLTPTQASLARSRSTLMLSEQASDSVSHACPHVAPAGSLKSSYKSSPTRNVERKKIASTSGGGDAGKGAPAGVEASPTEKMKRGPRATASVPSVGLMSPLRSISKRSSSPVTSKATSKAYPQSPKNTKPPYPGSPVKYRLPSFSGQETPKKKADKEKSNKEKEGTLPQQAASSPKEEVPEKHVADRQATEKHEKHEATAGKAKGGRASGKPTAGTTDAGEATKILSEKRRQARLQKEQEEQERLEKEKQDKLEREELKRKAEEERLRLEEARKQEEEKKHLEEEEKRKVAEEAKRKAKEALLLKEEQEKEKQEKEKQEKAMIVKQKEAAEAKAQEAAKQMRLKREQIMLQMEQERLERKKRIDEIMKRTRKSDVSLEVKKEDPKVELQSALCVENKTEPMVPNKIEISVLNTFQEVNVVEHAALETFPQDVFTDELKPVEGLVHLDTLDGKSNSLDDSTEEVQSMDMSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPIFPKRSSENLSLDDCNKNLIEGFNSPGQENTLNTFC", "length": 765, "header": "tr|A0AAA9SFZ5-1|A0AAA9SFZ5_BOVIN Isoform 1 of MAP7 domain containing 2 OS=Bos taurus OX=9913 GN=MAP7D2 PE=3 SV=1 CANONICAL=A0AAA9SFZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5/entry#A0AAA9RY56-1", "sequence": { "sequence": "MEHGVGYAAATAGTEGATRAPPLPGKMAEPGAVRTSPPNHRPSGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWKKLEEQRQREEQKRAAVEEKRKQKLREEEERLEAMMRRSLERSQQLELKKKCSSGGASLAAGPGGRDACDKLSTSTMNLPKQTEPPMSKRLSSSTAAISYSPDRVSHACPHVAPAGSLKSSYKSSPTRNVERKKIASTSGGGDAGKGAPAGVEASPTEKMKRGPRATASVPSVGLMSPLRSISKRSSSPVTSKATSKAYPQSPKNTKPPYPGSPVKYRLPSFSGQETPKKKADKEKSNKEKEGTLPQQAASSPKEEVPEKHVADRQATEKHEKHEATAGKAKGGRASGKPTAGTTDAGEATKILSEKRRQARLQKEQEEQERLEKEKQDKLEREELKRKAEEERLRLEEARKQEEEKKHLEEEEKRKVAEEAKRKAKEALLLKEEQEKEKQEKEKQEKAMIVKQKEAAEAKAQEAAKQMRLKREQIMLQMEQERLERKKRIDEIMKRTRKSDVSLEVKKEDPKVELQSALCVENKTEPMVPNKIEISVLNTFQEVNVVEHAALETFPQDVFTDELKPVEGLVHLDTLDGKSNSLDDSTEEVQSMDMSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPIFPKRSSENLSLDDCNKNLIEGFNSPGQENTLNTFC", "length": 724, "header": "tr|A0AAA9RY56-1|A0AAA9SFZ5_BOVIN Computationally mapped isoform of MAP7 domain containing 2 OS=Bos taurus OX=9913 GN=MAP7D2 PE=3 SV=1 CANONICAL=A0AAA9SFZ5-1" }, "locus": { "chromosome": "X", "start_pos": 123178981, "end_pos": 123081110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099524.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099524.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078480.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078480.1" } ] } }, { "isoform_ac": "A0AAA9SFZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5/entry#A0AAA9SFZ5-1", "sequence": { "sequence": "MEHGVGYAAATAGTEGATRAPPLPGKMAEPGAVRTSPPNHRPSGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWKKLEEQRQREEQKRAAVEEKRKQKLREEEERLEAMMRRSLERSQQLELKKKCSSGGASLAAGPGGRDACDKLSTSTMNLPKQTEPPMSKRLSSSTAAISYSPDRAHRMHLSPMETFLVMRLLTPTQASLARSRSTLMLSEQASDSVSHACPHVAPAGSLKSSYKSSPTRNVERKKIASTSGGGDAGKGAPAGVEASPTEKMKRGPRATASVPSVGLMSPLRSISKRSSSPVTSKATSKAYPQSPKNTKPPYPGSPVKYRLPSFSGQETPKKKADKEKSNKEKEGTLPQQAASSPKEEVPEKHVADRQATEKHEKHEATAGKAKGGRASGKPTAGTTDAGEATKILSEKRRQARLQKEQEEQERLEKEKQDKLEREELKRKAEEERLRLEEARKQEEEKKHLEEEEKRKVAEEAKRKAKEALLLKEEQEKEKQEKEKQEKAMIVKQKEAAEAKAQEAAKQMRLKREQIMLQMEQERLERKKRIDEIMKRTRKSDVSLEVKKEDPKVELQSALCVENKTEPMVPNKIEISVLNTFQEVNVVEHAALETFPQDVFTDELKPVEGLVHLDTLDGKSNSLDDSTEEVQSMDMSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPIFPKRSSENLSLDDCNKNLIEGFNSPGQENTLNTFC", "length": 765, "header": "tr|A0AAA9SFZ5-1|A0AAA9SFZ5_BOVIN Isoform 1 of MAP7 domain containing 2 OS=Bos taurus OX=9913 GN=MAP7D2 PE=3 SV=1 CANONICAL=A0AAA9SFZ5-1" }, "locus": { "chromosome": "X", "start_pos": 123178981, "end_pos": 123081110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084292.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084292.1" } ] } }, { "isoform_ac": "A0ABI0NLV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5/entry#A0ABI0NLV5-1", "sequence": { "sequence": "MEHGVGYAAATAGTEGATRAPPLPGKMAEPGAVRTSPPNHRPSGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWKKLEEQRQREEQKRAAVEEKRKQKLREEEERLEAMMRRSLERSQQLELKKKCSSGGASLAAGPGGRDGESGNTPPPPLGLAASTLPLDPGTTAAAAESTNAPAGSLKSSYKSSPTRNVERKKIASTSGGGDAGKGAPAGVEASPTEKMKRGPRATASVPSVGLMSPLRSISKRSSSPVTSKATSKAYPQSPKNTKPPYPGSPVKYRLPSFSGQETPKKKADKEKSNKEKEGTLPQQAASSPKEEVPEKHVADRQATEKHEKHEATAGKAKGGRASGKPTAGTTDAGEATKILSEKRRQARLQKEQEEQERLEKEKQDKLEREELKRKAEEERLRLEEARKQEEEKKHLEEEEKRKVAEEAKRKAKEALLLKEEQEKEKQEKEKQEKAMIVKQKEAAEAKAQEAAKQMRLKREQIMLQMEQERLERKKRIDEIMKRTRKSDVSLEVKKEDPKVELQSALCVENKTEPMVPNKIEISVLNTFQEVNVVEHAALETFPQDVFTDELKPVEGLVHLDTLDGKSNSLDDSTEEVQSMDMSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPIFPKRSSENLSLDDCNKNLIEGFNSPGQENTLNTFC", "length": 712, "header": "tr|A0ABI0NLV5-1|A0ABI0NLV5_BOVIN Computationally mapped isoform of MAP7 domain containing 2 OS=Bos taurus OX=9913 GN=MAP7D2 PE=3 SV=1 CANONICAL=A0AAA9SFZ5-1" }, "locus": { "chromosome": "X", "start_pos": 123178981, "end_pos": 123081110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106291.1" } ] } }, { "isoform_ac": "E1BF55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5/entry#E1BF55-1", "sequence": { "sequence": "MEHGVGYAAATAGTEGATRAPPLPGKMAEPGAVRTSPPNHRPSGMEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQIEERWKKLEEQRQREEQKRAAVEEKRKQKLREEEERLEAMMRRSLERSQQLELKKKCSSGGASLAAGPGGRDAPAGSLKSSYKSSPTRNVERKKIASTSGGGDAGKGAPAGVEASPTEKMKRGPRATASVPSVGLMSPLRSISKRSSSPVTSKATSKAYPQSPKNTKPPYPGSPVKYRLPSFSGQETPKKKADKEKSNKEKEGTLPQQAASSPKEEVPEKHVADRQATEKHEKHEATAGKAKGGRASGKPTAGTTDAGEATKILSEKRRQARLQKEQEEQERLEKEKQDKLEREELKRKAEEERLRLEEARKQEEEKKHLEEEEKRKVAEEAKRKAKEALLLKEEQEKEKQEKEKQEKAMIVKQKEAAEAKAQEAAKQMRLKREQIMLQMEQERLERKKRIDEIMKRTRKSDVSLEVKKEDPKVELQSALCVENKTEPMVPNKIEISVLNTFQEVNVVEHAALETFPQDVFTDELKPVEGLVHLDTLDGKSNSLDDSTEEVQSMDMSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPIFPKRSSENLSLDDCNKNLIEGFNSPGQENTLNTFC", "length": 679, "header": "tr|E1BF55-1|A0AAA9SFZ5_BOVIN Computationally mapped isoform of MAP7 domain containing 2 OS=Bos taurus OX=9913 GN=MAP7D2 PE=3 SV=4 CANONICAL=A0AAA9SFZ5-1" }, "locus": { "chromosome": "X", "start_pos": 123178981, "end_pos": 123081110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023440.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023440.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023440.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023440.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" }, { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" }, { "name": "microtubule stabilizing activity", "id": "GO:0140778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140778", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 610, "end_pos": 612, "annotation": "n_glycosylation_sequon" }, { "start_pos": 711, "end_pos": 713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 610, "end_pos": 612 }, { "start_pos": 711, "end_pos": 713 }, { "start_pos": 738, "end_pos": 740 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF70-1", "uniprot_ac": "A0AAA9SF70", "uniprot_id": "A0AAA9SF70_BOVIN", "mass": { "chemical_mass": 135740.0, "monoisotopic_mass": 135740.0 }, "refseq": {}, "gene_names": [ { "name": "LRIG3", "type": "recommended", "evidence": [ { "id": "A0AAA9SF70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70" } ] } ], "protein_names": [ { "name": "Leucine rich repeats and immunoglobulin like domains 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SF70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRIG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70", "locus": { "chromosome": "5", "start_pos": 54612806, "end_pos": 54559651, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002227", "url": "https://www.ensembl.org/id/ENSBTAG00000002227" } ] } } ], "crossref": [ { "id": "A0AAA9SF70", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SF70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002227", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05763", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05763", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BN69", "url": "https://www.orthodb.org/?gene=E1BN69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN69", "url": "https://www.uniprot.org/uniprotkb/E1BN69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN69-1", "url": "https://www.uniprot.org/uniprotkb/E1BN69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGARGSGQHRPSAPAHGDLALSCKEKAKKFLLPARRASVRGRCSHCNSATAGRCFRFPCGCPGARKSSAAWTKKKGAYLRARGGGRAPAAPSAGIHYRLEVGAGPRVSAACGDPGRARSCGTTMGAPRVRALAAALGLLLCEVLGHAGPAEGGGLEALGPPSGVGAEHQCPTPCRCFGDLLDCSRQRLAHLPEPLPSWIARLDLSHNRLSFIKASSLSHLHSLREVKLNNNELETIPNLGPVTANITLLSLAGNKIVEILPEHLRQFQSLETLDLSGNNISELKTALPPLQLKYLYINSNRVTSMEPGYFDNLASTLLVLKLNRNRISALPPKMFKLPQLQHLELNRNKIKNIDGLTFQGLGALKSLKMQRNGVTRLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAISRISPDAWEFCQKLSELDLTYNHLSRLDDSSFLGLSLLNTLHIGNNRVNYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLKRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLRNVEFTSEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAALGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDISDAGKYTCEMSNTLGTERGHVRLSVIPTPTCDSPQMTASSLDDDGWATVGIVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYISSENGSHHQFVTSSGGGFFLPQHDSNGTCHIDNSSEADVEAATDPFLCPFLGPSGPVYLKGSVYGSDPFEAYHTGCGPDLRSALMDHYEPSYIKKKECYPCPHPSEESCEQSVSDTGWPSHAKKLLSSSYSQHEGPGMNNLCLNKSSADFSPSPEPPSVTLSNSFMGTFGKPLRRPHLDAFSSSGQSSDCQPRAFHLKARSSPNLDYESEEDGKERTDFQQENHTCTHKQTLESHRTSNFQSFDLDT", "length": 1242, "header": "tr|A0AAA9SF70-1|A0AAA9SF70_BOVIN Isoform 1 of Leucine rich repeats and immunoglobulin like domains 3 OS=Bos taurus OX=9913 GN=LRIG3 PE=4 SV=1 CANONICAL=A0AAA9SF70-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70/entry#A0AAA9RYQ2-1", "sequence": { "sequence": "MAVSPHPEEEGIPIWSLRSPSFPAAAVTCKGESKDRLQWDLSHNRLSFIKASSLSHLHSLREVKLNNNELETIPNLGPVTANITLLSLAGNKIVEILPEHLRQFQSLETLDLSGNNISELKTALPPLQLKYLYINSNRVTSMEPGYFDNLASTLLVLKLNRNRISALPPKMFKLPQLQHLELNRNKIKNIDGLTFQGLGALKSLKMQRNGVTRLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAISRISPDAWEFCQKLSELDLTYNHLSRLDDSSFLGLSLLNTLHIGNNRVNYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLKRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLRNVEFTSEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAALGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDISDAGKYTCEMSNTLGTERGHVRLSVIPTPTCDSPQMTASSLDDDGWATVGIVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYISSENGSHHQFVTSSGGGFFLPQHDSNGTCHIDNSSEADVEAATDPFLCPFLGPSGPVYLKGSVYGSDPFEAYHTGCGPDLRSALMDHYEPSYIKKKECYPCPHPSEESCEQSVSDTGWPSHAKKLLSSSYSQHEGPGMNNLCLNKSSADFSPSPEPPSVTLSNSFMGTFGKPLRRPHLDAFSSSGQSSDCQPRAFHLKARSSPNLDYESEEDGKERTDFQQENHTCTHKQTLESHRTSNFQSFDLDT", "length": 1079, "header": "tr|A0AAA9RYQ2-1|A0AAA9SF70_BOVIN Computationally mapped isoform of Leucine rich repeats and immunoglobulin like domains 3 OS=Bos taurus OX=9913 GN=LRIG3 PE=4 SV=1 CANONICAL=A0AAA9SF70-1" }, "locus": { "chromosome": "5", "start_pos": 54611768, "end_pos": 54559850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076408.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076408.1" } ] } }, { "isoform_ac": "A0AAA9SF70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70/entry#A0AAA9SF70-1", "sequence": { "sequence": "MGARGSGQHRPSAPAHGDLALSCKEKAKKFLLPARRASVRGRCSHCNSATAGRCFRFPCGCPGARKSSAAWTKKKGAYLRARGGGRAPAAPSAGIHYRLEVGAGPRVSAACGDPGRARSCGTTMGAPRVRALAAALGLLLCEVLGHAGPAEGGGLEALGPPSGVGAEHQCPTPCRCFGDLLDCSRQRLAHLPEPLPSWIARLDLSHNRLSFIKASSLSHLHSLREVKLNNNELETIPNLGPVTANITLLSLAGNKIVEILPEHLRQFQSLETLDLSGNNISELKTALPPLQLKYLYINSNRVTSMEPGYFDNLASTLLVLKLNRNRISALPPKMFKLPQLQHLELNRNKIKNIDGLTFQGLGALKSLKMQRNGVTRLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAISRISPDAWEFCQKLSELDLTYNHLSRLDDSSFLGLSLLNTLHIGNNRVNYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLKRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLRNVEFTSEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAALGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDISDAGKYTCEMSNTLGTERGHVRLSVIPTPTCDSPQMTASSLDDDGWATVGIVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYISSENGSHHQFVTSSGGGFFLPQHDSNGTCHIDNSSEADVEAATDPFLCPFLGPSGPVYLKGSVYGSDPFEAYHTGCGPDLRSALMDHYEPSYIKKKECYPCPHPSEESCEQSVSDTGWPSHAKKLLSSSYSQHEGPGMNNLCLNKSSADFSPSPEPPSVTLSNSFMGTFGKPLRRPHLDAFSSSGQSSDCQPRAFHLKARSSPNLDYESEEDGKERTDFQQENHTCTHKQTLESHRTSNFQSFDLDT", "length": 1242, "header": "tr|A0AAA9SF70-1|A0AAA9SF70_BOVIN Isoform 1 of Leucine rich repeats and immunoglobulin like domains 3 OS=Bos taurus OX=9913 GN=LRIG3 PE=4 SV=1 CANONICAL=A0AAA9SF70-1" }, "locus": { "chromosome": "5", "start_pos": 54611768, "end_pos": 54560749, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099635.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099635.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082258.1" } ] } }, { "isoform_ac": "E1BN69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70/entry#E1BN69-1", "sequence": { "sequence": "MGAPRVRALAAALGLLLCEVLGHAGPAEGGGLEALGPPSGVGAEHQCPTPCRCFGDLLDCSRQRLAHLPEPLPSWIARLDLSHNRLSFIKASSLSHLHSLREVKLNNNELETIPNLGPVTANITLLSLAGNKIVEILPEHLRQFQSLETLDLSGNNISELKTALPPLQLKYLYINSNRVTSMEPGYFDNLASTLLVLKLNRNRISALPPKMFKLPQLQHLELNRNKIKNIDGLTFQGLGALKSLKMQRNGVTRLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAISRISPDAWEFCQKLSELDLTYNHLSRLDDSSFLGLSLLNTLHIGNNRVNYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLKRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLRNVEFTSEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAALGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDISDAGKYTCEMSNTLGTERGHVRLSVIPTPTCDSPQMTASSLDDDGWATVGIVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYISSENGSHHQFVTSSGGGFFLPQHDSNGCGPDLRSALMDHYEPSYIKKKECYPCPHPSEESCEQSVSDTGWPSHAKKLLSSSYSQHEGPGMNNLCLNKSSADFSPSPEPPSVTLSNSFMGTFGKPLRRPHLDAFSSSGQSSDCQPRAFHLKARSSPNLDYESEEDGKERTDFQQENHTCTHKQTLESHRTSNFQSFDLDT", "length": 1071, "header": "tr|E1BN69-1|A0AAA9SF70_BOVIN Computationally mapped isoform of Leucine rich repeats and immunoglobulin like domains 3 OS=Bos taurus OX=9913 GN=LRIG3 PE=4 SV=2 CANONICAL=A0AAA9SF70-1" }, "locus": { "chromosome": "5", "start_pos": 54611768, "end_pos": 54561118, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002883.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002883.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002883.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002883.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "otolith morphogenesis", "id": "GO:0032474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032474", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1021, "end_pos": 1023, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1028, "end_pos": 1030, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1139, "end_pos": 1141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1218, "end_pos": 1220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" }, { "start_pos": 638, "end_pos": 640, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" }, { "start_pos": 852, "end_pos": 854, "annotation": "n_glycosylation_sequon" }, { "start_pos": 999, "end_pos": 1001, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SF70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF70" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 622, "end_pos": 721, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1021, "end_pos": 1023 }, { "start_pos": 1028, "end_pos": 1030 }, { "start_pos": 1139, "end_pos": 1141 }, { "start_pos": 1218, "end_pos": 1220 }, { "start_pos": 245, "end_pos": 247 }, { "start_pos": 279, "end_pos": 281 }, { "start_pos": 397, "end_pos": 399 }, { "start_pos": 565, "end_pos": 567 }, { "start_pos": 592, "end_pos": 594 }, { "start_pos": 638, "end_pos": 640 }, { "start_pos": 811, "end_pos": 813 }, { "start_pos": 852, "end_pos": 854 }, { "start_pos": 999, "end_pos": 1001 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFN2-1", "uniprot_ac": "A0AAA9SFN2", "uniprot_id": "A0AAA9SFN2_BOVIN", "mass": { "chemical_mass": 145704.0, "monoisotopic_mass": 145704.0 }, "refseq": {}, "gene_names": [ { "name": "IFT122", "type": "recommended", "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ] } ], "protein_names": [ { "name": "Intraflagellar transport protein 122 homolog", "type": "recommended", "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia.", "evidence": [ { "database": "UniProtKB", "id": "F1MG59", "url": "https://www.uniprot.org/uniprotkb/F1MG59#function" }, { "database": "UniProtKB", "id": "ARBA00060184", "url": "https://www.uniprot.org/uniprotkb/ARBA00060184#function" }, { "database": "UniProtKB", "id": "A0AAA9RYT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT6#function" }, { "database": "UniProtKB", "id": "A0AAA9S014", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S014#function" }, { "database": "UniProtKB", "id": "A0AAA9SS22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS22#function" }, { "database": "UniProtKB", "id": "A0AAA9SZ69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ69#function" }, { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT122", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2", "locus": { "chromosome": "22", "start_pos": 56239340, "end_pos": 56308252, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019121", "url": "https://www.ensembl.org/id/ENSBTAG00000019121" } ] } } ], "crossref": [ { "id": "A0AAA9SFN2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFN2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019121", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019121", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056838", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056838", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057411", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057411", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MG59", "url": "https://www.orthodb.org/?gene=F1MG59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12764", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12764", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12764:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12764:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23377", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23377", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23381", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23381", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25143", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25143", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25295", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25295", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5610787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RYT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S014", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S014", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S014-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S014-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG59", "url": "https://www.uniprot.org/uniprotkb/F1MG59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG59-1", "url": "https://www.uniprot.org/uniprotkb/F1MG59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTSWSIIVSSLYLPPVRMNVFPGLHKARGMAINTALPHNDSIQCVSYNPITHQLASCSSSDIGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGSLSPIWSISWNPSSRWENFWMNIEIEDSEEAIVSRYFQDIPSTLKSAVYSSQGSEAEEDEPEEEDNGAGDDSLEERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFSDAAYYYWMLSMQCLDIAQDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLLLQHTCCPYCRRRMDDPSP", "length": 1276, "header": "tr|A0AAA9SFN2-1|A0AAA9SFN2_BOVIN Isoform 1 of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=1 CANONICAL=A0AAA9SFN2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#A0AAA9RYT6-1", "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPITHQLASCSSSDIGLWSPEQKSVSKHKSSSKITCCREERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFSDAAYYYWMLSMQCLDIAQDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYAPPLPVSAEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLLLQHTCCPYCRRRMDDPSP", "length": 1141, "header": "tr|A0AAA9RYT6-1|A0AAA9SFN2_BOVIN Computationally mapped isoform of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=1 CANONICAL=A0AAA9SFN2-1" }, "locus": { "chromosome": "22", "start_pos": 56308180, "end_pos": 56239712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089807.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089807.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078736.1" } ] } }, { "isoform_ac": "A0AAA9S014-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#A0AAA9S014-1", "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPITHQLASCSSSDIGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGSLSPIWSISWNPSREERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLLLQHTCCPYCRRRMDDPSP", "length": 1135, "header": "tr|A0AAA9S014-1|A0AAA9SFN2_BOVIN Computationally mapped isoform of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=1 CANONICAL=A0AAA9SFN2-1" }, "locus": { "chromosome": "22", "start_pos": 56308180, "end_pos": 56239712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075406.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075406.1" } ] } }, { "isoform_ac": "A0AAA9SFN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#A0AAA9SFN2-1", "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTSWSIIVSSLYLPPVRMNVFPGLHKARGMAINTALPHNDSIQCVSYNPITHQLASCSSSDIGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGSLSPIWSISWNPSSRWENFWMNIEIEDSEEAIVSRYFQDIPSTLKSAVYSSQGSEAEEDEPEEEDNGAGDDSLEERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFSDAAYYYWMLSMQCLDIAQDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLLLQHTCCPYCRRRMDDPSP", "length": 1276, "header": "tr|A0AAA9SFN2-1|A0AAA9SFN2_BOVIN Isoform 1 of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=1 CANONICAL=A0AAA9SFN2-1" }, "locus": { "chromosome": "22", "start_pos": 56308180, "end_pos": 56239712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098662.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098662.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082418.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082418.1" } ] } }, { "isoform_ac": "A0AAA9SS22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#A0AAA9SS22-1", "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGSLSPIWSISWNPSSRWENFWMNIEIEDSEEAIVSRYFQDIPSTLKSAVYSSQGSEAEEDEPEEEDNGAGDDSLEERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFSDAAYYYWMLSMQCLDIAQDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLLLQHTCCPYCRRRMDDPSP", "length": 1189, "header": "tr|A0AAA9SS22-1|A0AAA9SS22_BOVIN Computationally mapped isoform of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=1 CANONICAL=A0AAA9SFN2-1" }, "locus": { "chromosome": "22", "start_pos": 56308180, "end_pos": 56239712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118792.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118792.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085811.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085811.1" } ] } }, { "isoform_ac": "A0AAA9SZ69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#A0AAA9SZ69-1", "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPITHQLASCSSSDIGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGSLSPIWSISWNPSREERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFSDAAYYYWMLSMQCLDIAQDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEVPACVRGPRVLPSSCCCASRMVPLGRPGIGGAHVSLSGQGQGPWAGGEAWPSLVTSTASRASLDHLLGICPLTLCSLYLPFIQEGRPVGCTFELHFG", "length": 1195, "header": "tr|A0AAA9SZ69-1|A0AAA9SZ69_BOVIN Computationally mapped isoform of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=1 CANONICAL=A0AAA9SFN2-1" }, "locus": { "chromosome": "22", "start_pos": 56308180, "end_pos": 56239979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097398.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097398.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090717.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090717.1" } ] } }, { "isoform_ac": "F1MG59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2/entry#F1MG59-1", "sequence": { "sequence": "MRAVLTWRDKVEQCVYDLAFKPDGTQLIVAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPITHQLASCSSSDIGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGSLSPIWSISWNPSREERNDILAVADWGQKLSFYQLSGKQIGKDHSLNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGAVGEQTSWVWTCKVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYKNRLAIQLPEKILIYELYSEDSLDMRYRVKEKIARKFECNLLVVCADHIILCQERRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDMCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFREAYQIACLGVTDADWRELAMEALEGLEFETAKKAFTRVQDLRYLELINSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTELRMFEYAKDFLGSEDPKETKMLITKQADWARNINEPKAAVEMYISAGEHCKAIEISGEHGWVDMLIDIARKLDKAEREPLLMCAHFFKKLDNPGYAAETYLKIGDLKSLVQLHVETQRWDEVSPAIKRNLFAALREPTQSLKIKCFRFCAASAVQKQTVLSLNPAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFSDAAYYYWMLSMQCLDIAQDPAQKEVMLSKFHHFQHLAELYHGYHVIHRYVEEPFSFHLPETLFNISRFLLHSLTKDTPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLQGLQIPARFQKSIELGSLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFVFSASSYEVLHLVEFYLEEGITDEEAVSLIDLEAPRLKRENKWQEITSNNAQTLRLDESMDSVGDDDPFTAKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLLLQHTCCPYCRRRMDDPSP", "length": 1225, "header": "tr|F1MG59-1|F1MG59_BOVIN Computationally mapped isoform of Intraflagellar transport protein 122 homolog OS=Bos taurus OX=9913 GN=IFT122 PE=4 SV=4 CANONICAL=A0AAA9SFN2-1" }, "locus": { "chromosome": "22", "start_pos": 56308180, "end_pos": 56239712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036487.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036487.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036344.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036344.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5610787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "resource": "Reactome", "description": "Hedgehog 'off' state" }, { "id": "R-BTA-5620924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "resource": "Reactome", "description": "Intraflagellar transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "establishment of protein localization", "id": "GO:0045184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "regulation of smoothened signaling pathway", "id": "GO:0008589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "camera-type eye morphogenesis", "id": "GO:0048593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "protein localization to non-motile cilium", "id": "GO:0097499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097499", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" }, { "name": "intraciliary retrograde transport", "id": "GO:0035721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035721", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1011, "end_pos": 1013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" }, { "id": "PF23377", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23377" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT122 second beta-propeller", "eco_id": "ECO_0000259", "start_pos": 391, "end_pos": 645, "start_aa": "His", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" }, { "id": "PF25144", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25144" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT122 zinc ribbon", "eco_id": "ECO_0000259", "start_pos": 1085, "end_pos": 1129, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" }, { "id": "PF23381", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23381" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT122/SMU1 beta-propeller", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 100, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN2" }, { "id": "PF25295", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25295" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Intraflagellar transport protein 122 homolog TPR", "eco_id": "ECO_0000259", "start_pos": 652, "end_pos": 1032, "start_aa": "Gln", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1011, "end_pos": 1013 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 633, "end_pos": 635 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFD8-1", "uniprot_ac": "A0AAA9SFD8", "uniprot_id": "A0AAA9SFD8_BOVIN", "mass": { "chemical_mass": 24141.0, "monoisotopic_mass": 24141.0 }, "refseq": {}, "gene_names": [ { "name": "JCHAIN", "type": "recommended", "evidence": [ { "id": "A0AAA9SFD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8" } ] } ], "protein_names": [ { "name": "Joining chain of multimeric IgA and IgM", "type": "synonym", "evidence": [ { "id": "A0AAA9SFD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JCHAIN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8", "locus": { "chromosome": "6", "start_pos": 86032997, "end_pos": 86071698, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018531", "url": "https://www.ensembl.org/id/ENSBTAG00000018531" } ] } } ], "crossref": [ { "id": "A0AAA9SFD8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR024110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10070:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10070:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T056", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T056", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T056-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T056-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXA6", "url": "https://www.uniprot.org/uniprotkb/F6PXA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXA6-1", "url": "https://www.uniprot.org/uniprotkb/F6PXA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VQVAFAEVLCRCLGKSRTTQPGRLSPSTGETDNSGSRPLACICHRKTPSLIFPARLCCPQDFSGKNSRVGCHFFLQGIFPTKGLNPCLLRFLHCRWILYRIIPSAEDPSQDIVERNVRIIVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 214, "header": "tr|A0AAA9SFD8-1|A0AAA9SFD8_BOVIN Isoform 1 of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=1 CANONICAL=A0AAA9SFD8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#A0AAA9RYV6-1", "sequence": { "sequence": "ISRPARLCCPQDFSGKNSRVGCHFFLQGIFPTKGLNPCLLRFLHCRWILYRIIPSAEDPSQDIVERNVRIIVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 165, "header": "tr|A0AAA9RYV6-1|A0AAA9SFD8_BOVIN Computationally mapped isoform of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=1 CANONICAL=A0AAA9SFD8-1" }, "locus": { "chromosome": "6", "start_pos": 86067264, "end_pos": 86033699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097391.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097391.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078752.1" } ] } }, { "isoform_ac": "A0AAA9SFD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#A0AAA9SFD8-1", "sequence": { "sequence": "VQVAFAEVLCRCLGKSRTTQPGRLSPSTGETDNSGSRPLACICHRKTPSLIFPARLCCPQDFSGKNSRVGCHFFLQGIFPTKGLNPCLLRFLHCRWILYRIIPSAEDPSQDIVERNVRIIVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 214, "header": "tr|A0AAA9SFD8-1|A0AAA9SFD8_BOVIN Isoform 1 of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=1 CANONICAL=A0AAA9SFD8-1" }, "locus": { "chromosome": "6", "start_pos": 86054049, "end_pos": 86033699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123144.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123144.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082577.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082577.1" } ] } }, { "isoform_ac": "A0AAA9SQF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#A0AAA9SQF7-1", "sequence": { "sequence": "VQVAFAEVLCRCLGKSRTTQPGRLSPSTGETDNSGSRPLACICHRKTPSLIFPARLCCPQDFSGKNSRVGCHFFLQGIFPTKGLNPCLLRFLHCRWILYSVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 194, "header": "tr|A0AAA9SQF7-1|A0AAA9SQF7_BOVIN Computationally mapped isoform of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=2 CANONICAL=A0AAA9SFD8-1" }, "locus": { "chromosome": "6", "start_pos": 86054049, "end_pos": 86033699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113259.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113259.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086249.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086249.2" } ] } }, { "isoform_ac": "A0AAA9T056-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#A0AAA9T056-1", "sequence": { "sequence": "TRTSGWSFGPFRVGTVGNEVRFRNLFGPVLTLASLGVARVTARLTAALLYHVVDLNRTVILQARSTASGTDVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 165, "header": "tr|A0AAA9T056-1|A0AAA9T056_BOVIN Computationally mapped isoform of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=2 CANONICAL=A0AAA9SFD8-1" }, "locus": { "chromosome": "6", "start_pos": 86071499, "end_pos": 86033699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122068.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122068.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089899.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089899.2" } ] } }, { "isoform_ac": "A0AAA9T1E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#A0AAA9T1E6-1", "sequence": { "sequence": "MSPAFPALQVDSLQLQFFKRSEVKMKNCLLFWGVLAIFVMAVLVTAQDENERIVVDNKCKCARITSRIIPSAEDPSQDIVERNVRIIVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 181, "header": "tr|A0AAA9T1E6-1|A0AAA9T1E6_BOVIN Computationally mapped isoform of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=1 CANONICAL=A0AAA9SFD8-1" }, "locus": { "chromosome": "6", "start_pos": 86050031, "end_pos": 86033699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134951.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134951.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091526.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091526.1" } ] } }, { "isoform_ac": "F6PXA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD8/entry#F6PXA6-1", "sequence": { "sequence": "MLLQFFKRSEVKMKNCLLFWGVLAIFVMAVLVTAQDENERIVVDNKCKCARITSRIIPSAEDPSQDIVERNVRIIVPLNSRENISDPTSPMRTKFVYHLSDLCKKCDTTEVELEDQVVTASQSNICDSDAETCYTYDRNKCYTNRVKLSYRGQTKMVETALTPDSCYPD", "length": 169, "header": "tr|F6PXA6-1|F6PXA6_BOVIN Computationally mapped isoform of Joining chain of multimeric IgA and IgM OS=Bos taurus OX=9913 GN=JCHAIN PE=1 SV=1 CANONICAL=A0AAA9SFD8-1" }, "locus": { "chromosome": "6", "start_pos": 86054994, "end_pos": 86033699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024666.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024666.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024666.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024666.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGS4-1", "uniprot_ac": "A0AAA9SGS4", "uniprot_id": "A0AAA9SGS4_BOVIN", "mass": { "chemical_mass": 32230.0, "monoisotopic_mass": 32230.0 }, "refseq": { "ac": "XP_059733774", "name": "myosin light chain 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733774" }, "gene_names": [ { "name": "MYL4", "type": "recommended", "evidence": [ { "id": "A0AAA9SGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4" } ] }, { "name": "MYL4", "type": "synonym", "evidence": [ { "id": "XP_059733774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733774" } ] } ], "protein_names": [ { "name": "Myosin light chain 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#names_and_taxonomy" } ] }, { "name": "myosin light chain 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059733774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733774" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4", "locus": { "chromosome": "19", "start_pos": 46300142, "end_pos": 46261249, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021916", "url": "https://www.ensembl.org/id/ENSBTAG00000021916" } ] } } ], "crossref": [ { "id": "A0AAA9SGS4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504201", "url": "https://www.ncbi.nlm.nih.gov/gene/504201", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_059733774", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733774", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S038", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S038", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S038-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S038-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S573", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S573", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S573-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S573-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T545", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T545", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T545-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T545-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEAEREPSTSERDTEKPEVERRAREPDGKARRRPEIPEVNRRRRTPLPEVVEEYRRRPSVIQSGFPVTETHIASKSCHHKSRSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 287, "header": "tr|A0AAA9SGS4-1|A0AAA9SGS4_BOVIN Isoform 1 of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S038-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9S038-1", "sequence": { "sequence": "MSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 205, "header": "tr|A0AAA9S038-1|A0AAA9SGS4_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46282882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089266.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089266.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078292.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078292.1" } ] } }, { "isoform_ac": "A0AAA9S573-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9S573-1", "sequence": { "sequence": "MNEAVGGEPRNLRSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 217, "header": "tr|A0AAA9S573-1|A0AAA9SGS4_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46284689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097187.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097187.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081090.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081090.1" } ] } }, { "isoform_ac": "A0AAA9SGS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9SGS4-1", "sequence": { "sequence": "MGEAEREPSTSERDTEKPEVERRAREPDGKARRRPEIPEVNRRRRTPLPEVVEEYRRRPSVIQSGFPVTETHIASKSCHHKSRSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 287, "header": "tr|A0AAA9SGS4-1|A0AAA9SGS4_BOVIN Isoform 1 of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46261690, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117306.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117306.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081701.1" } ] } }, { "isoform_ac": "A0AAA9SKE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9SKE3-1", "sequence": { "sequence": "MGIPSDGDPHCFQVLPPQITVRSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 226, "header": "tr|A0AAA9SKE3-1|A0AAA9SKE3_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46270681, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087650.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087650.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084391.1" } ] } }, { "isoform_ac": "A0AAA9SWH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9SWH4-1", "sequence": { "sequence": "MGFSRSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 209, "header": "tr|A0AAA9SWH4-1|A0AAA9SWH4_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46280332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132948.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132948.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090827.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090827.1" } ] } }, { "isoform_ac": "A0AAA9T2R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9T2R8-1", "sequence": { "sequence": "THQRPLPGDGGGRARAEYLRAGHGKARSGETRAGARRKGPKETGNTRGESAEENTVAGSCRGVPETTERDPKQFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 215, "header": "tr|A0AAA9T2R8-1|A0AAA9T2R8_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46261665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103698.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103698.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092024.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092024.1" } ] } }, { "isoform_ac": "A0AAA9T545-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9T545-1", "sequence": { "sequence": "FSSVLLEEAEDDFLLFCWKNTIWNQETWLLALNLPLVTLRLRASHFFKPEFSLLQSEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 200, "header": "tr|A0AAA9T545-1|A0AAA9T545_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46293655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118065.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118065.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092946.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092946.1" } ] } }, { "isoform_ac": "A0AAA9TMN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9TMN2-1", "sequence": { "sequence": "MGSRARGLHGSRALEHRLSSCGCVAPGHLGSSRTRGRTYSPELAGRLPSSTAPSGKSLACRFLQCGSLCTSSRKGMSHLLGRAQQDNMPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 280, "header": "tr|A0AAA9TMN2-1|A0AAA9TMN2_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46282657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110664.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110664.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098497.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098497.1" } ] } }, { "isoform_ac": "A0AAA9TS68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAA9TS68-1", "sequence": { "sequence": "ETEGPRKLGVCLRPPVGQWQSWGGLTIQPCHLVRPESSLSAWDRHYCYWLTSEQILSLCKVAPHTAPSFGTQLGGSEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 219, "header": "tr|A0AAA9TS68-1|A0AAA9TS68_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46295764, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093522.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093522.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101224.1" } ] } }, { "isoform_ac": "A0AAF6DLF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4/entry#A0AAF6DLF0-1", "sequence": { "sequence": "MPPKKPEPKKEVAKPATAPAASPAPPPEPLKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGELKIAYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNSKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGTIVPNWVCSAGLEGEESRLAEQGEKMSEAEVEQLLAGQEDANGCINYEAFVKHIMSG", "length": 216, "header": "tr|A0AAF6DLF0-1|A0AAF6DLF0_BOVIN Computationally mapped isoform of Myosin light chain 4 OS=Bos taurus OX=9913 GN=MYL4 PE=4 SV=1 CANONICAL=A0AAA9SGS4-1" }, "locus": { "chromosome": "19", "start_pos": 46299475, "end_pos": 46285399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057007.5", "url": "https://www.ensembl.org/id/ENSBTAT00000057007.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050283.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050283.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS4" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 255, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 237, "end_pos": 239 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SED9-1", "uniprot_ac": "A0AAA9SED9", "uniprot_id": "A0AAA9SED9_BOVIN", "mass": { "chemical_mass": 70894.0, "monoisotopic_mass": 70894.0 }, "refseq": {}, "gene_names": [ { "name": "COL13A1", "type": "recommended", "evidence": [ { "id": "A0AAA9SED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ] } ], "protein_names": [ { "name": "Collagen type XIII alpha 1 chain", "type": "synonym", "evidence": [ { "id": "A0AAA9SED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL13A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9", "locus": { "chromosome": "28", "start_pos": 26248050, "end_pos": 26095666, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011741", "url": "https://www.ensembl.org/id/ENSBTAG00000011741" } ] } } ], "crossref": [ { "id": "A0AAA9SED9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SED9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011741", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011741", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37456", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37456", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37456:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37456:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S0K8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0K8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SED9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T980", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T980", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T980-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T980-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T997", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T997", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T997-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T997-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U105", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U105", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U105-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U105-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RND5", "url": "https://www.uniprot.org/uniprotkb/F6RND5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RND5-1", "url": "https://www.uniprot.org/uniprotkb/F6RND5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGDKGAIGMPGRVGGKGQPGEKGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHRLLPLLNSVRLAPPPVIKRRTFQGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGDPGATGKPGPPGLPGKRGQRGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGEKGEPGEKGDPGMEVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 727, "header": "tr|A0AAA9SED9-1|A0AAA9SED9_BOVIN Isoform 1 of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9S0K8-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGDKGAIGMPGRVGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHREHLSGSLAALRSNQIIILKGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 667, "header": "tr|A0AAA9S0K8-1|A0AAA9SED9_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108838.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108838.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075598.1" } ] } }, { "isoform_ac": "A0AAA9SED9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9SED9-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGDKGAIGMPGRVGGKGQPGEKGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHRLLPLLNSVRLAPPPVIKRRTFQGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGDPGATGKPGPPGLPGKRGQRGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGEKGEPGEKGDPGMEVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 727, "header": "tr|A0AAA9SED9-1|A0AAA9SED9_BOVIN Isoform 1 of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095036.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095036.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083765.1" } ] } }, { "isoform_ac": "A0AAA9SKN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9SKN6-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHREHLSGSLAALRSNQIIILKGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGEDGLPVQGCWNK", "length": 609, "header": "tr|A0AAA9SKN6-1|A0AAA9SKN6_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086904.1" } ] } }, { "isoform_ac": "A0AAA9SSR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9SSR4-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGGKGQPGEKGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHRLLPLLNSVRLAPPPVIKRRTFQGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGDPGATGKPGPPGLPGKRGQRGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGHRGFKGEKGEPGLPGLDGLDAPCPLGEDGLPVQGCWNK", "length": 683, "header": "tr|A0AAA9SSR4-1|A0AAA9SSR4_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120264.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120264.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087033.1" } ] } }, { "isoform_ac": "A0AAA9T980-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9T980-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHRLLPLLNSVRLAPPPVIKRRTFQGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 644, "header": "tr|A0AAA9T980-1|A0AAA9T980_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103655.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103655.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093172.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093172.1" } ] } }, { "isoform_ac": "A0AAA9T997-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9T997-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGGKGQPGEKGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHRLLPLLNSVRLAPPPVIKRRTFQGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGDPGATGKPGPPGLPGKRGQRGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 657, "header": "tr|A0AAA9T997-1|A0AAA9T997_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118558.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118558.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093194.1" } ] } }, { "isoform_ac": "A0AAA9TH34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9TH34-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGDKGAIGMPGRVGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHREHLSGSLAALRSNQIIILKLLPLLNSVRLAPPPVIKRRTFQGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGEKGEPGEKGDPGMEVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 716, "header": "tr|A0AAA9TH34-1|A0AAA9TH34_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131398.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131398.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096180.1" } ] } }, { "isoform_ac": "A0AAA9U105-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#A0AAA9U105-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPGPPGPAGRPGLPGDKGAIGMPGRVGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGLVGPWGQLGPQGQKGEKGQCGEYPHREHLSGSLAALRSNQIIILKGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGAPGTTVARMKGEPGIPGAKGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGEKGEIGLPGPGLDGEKGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGEKGEPGEKGDPGMEVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 694, "header": "tr|A0AAA9U105-1|A0AAA9U105_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=1 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094247.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094247.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102830.1" } ] } }, { "isoform_ac": "F6RND5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9/entry#F6RND5-1", "sequence": { "sequence": "MVAERSRKATAAGARGPAELDAPGTVALAVAPAERCARLPSPGSCGLLALALCSLALSLLAHFRTVELQARVLRLEAERGEQQMEPAILGRVNQLLDEKWKLHSRRRRETLKTSPGCHCPPEFQGPAGRPGLPGDKGAIGMPGRVGGKGQPGEKGAPGDAGMSIIGPRGPPGQPGTRGFPGFPGPIGLDGKPGRPGPKGEMGPQGQKGEKGQCGEYPHRGEQGQAGIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGYHGRKGERGMPGMPGKHGTKGEPGIPGAKGEKGAAGSPGPLGLLGQKGEKGDAGNSIEGGRGEPGLPGPPGPPGPKGEAGADGQPGPPGEQGDKGEPGPAGEQGPTGPKGSKGETGKGEMVDYNGNINEALQVSLSFLSGPPGLPGQIGPPGAPGIPGEKGEIGLPGPPDSMGKRGPRGKPGDVGPPGPQGPPGKPGPAGMKGEDGLPGSPGEKGEKGETGQPGPPGLDGPTGEKGEPGDQGRPGATGLPGPIGLPGFIGEKGEPGEKGDPGMEVPGPPGPEGPPGPPGLQGVPGPKGEAGLDGAKGDKGVQGEKGDRGPLGLPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK", "length": 685, "header": "tr|F6RND5-1|F6RND5_BOVIN Computationally mapped isoform of Collagen type XIII alpha 1 chain OS=Bos taurus OX=9913 GN=COL13A1 PE=4 SV=2 CANONICAL=A0AAA9SED9-1" }, "locus": { "chromosome": "28", "start_pos": 26246128, "end_pos": 26096194, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039811.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039811.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039599.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039599.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 639, "start_aa": "Thr", "end_pos": 639, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr639", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "morphogenesis of a branching structure", "id": "GO:0001763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001763", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "pmid": "" }, { "name": "endochondral ossification", "id": "GO:0001958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001958", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent conferring tensile strength", "id": "GO:0030020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SED9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SED9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 639 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHX7-1", "uniprot_ac": "A0AAA9SHX7", "uniprot_id": "A0AAA9SHX7_BOVIN", "mass": { "chemical_mass": 64551.0, "monoisotopic_mass": 64551.0 }, "refseq": { "ac": "XP_005228522", "name": "arylsulfatase L isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228522" }, "gene_names": [ { "name": "ARSL", "type": "recommended", "evidence": [ { "id": "A0AAA9SHX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7" } ] }, { "name": "ARSE", "type": "synonym", "evidence": [ { "id": "XP_005228522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228522" } ] }, { "name": "ARSL", "type": "synonym", "evidence": [ { "id": "XP_005228522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228522" } ] } ], "protein_names": [ { "name": "Arylsulfatase L", "type": "synonym", "evidence": [ { "id": "A0AAA9SHX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7/entry#names_and_taxonomy" } ] }, { "name": "arylsulfatase L isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005228522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228522" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARSL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7", "locus": { "chromosome": "X", "start_pos": 138666768, "end_pos": 138644483, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014932", "url": "https://www.ensembl.org/id/ENSBTAG00000014932" } ] } } ], "crossref": [ { "id": "505899", "url": "https://www.ncbi.nlm.nih.gov/gene/505899", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42693", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42693", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42693:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42693:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228522", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228522", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2C2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM97", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRLEHSWSWLALALAVLLGAKPSACGPPPGPRPNILLLMADDLGIGDVGCYGNTTIRTPNIDRLAADGVRLTQHLAAAPLCTPSRAAFLTGRYPLRSGMVSSQGLRVLQWTAVSGGLPPSEITFAKILKAKGYTTGLIGKWHLGLSCASPDDHCHHPLNHGFDHFYGMPFSMMADCERWELSEKRAVLESRLDVCFQLVALATLTLTIGKLTHLIPGASWTLVIWSAVVCLLLFATSCLVGALIMHADCFLMRNHSIAEQPMRSQRTTPLMLQEVSSFVKRHKQGPFLLFVSFLHVHTPLVTTENFRGRSPHGLYGDNTEEMDWMVGQILETLDTEGLTNSTLVYFTSDHGGSLEARFGNNQYGGWNGIYKGGKGMAGWEGGIRVPGIFRWPGVLPAGRVIHEPTSLMDIFPTVVHLAGGQVPQDRVVDGRDLLALLQGTARHSDHEFLMHYCESFLHAARWHQRDRGAVWKVHFTTPIFQPDGAGACYGQIVCPCSGNRVTHHAPPLLFDLSRDPSEAHALTPDTEPSFHQVVETVARAVAAHRQTLIPVPLQLDAADNTWKPWLQPCCGRFPFCWCDRDADPR", "length": 586, "header": "tr|A0AAA9SHX7-1|A0AAA9SHX7_BOVIN Isoform 1 of Arylsulfatase L OS=Bos taurus OX=9913 GN=ARSL PE=3 SV=1 CANONICAL=A0AAA9SHX7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7/entry#A0AAA9S2C2-1", "sequence": { "sequence": "MLRLEHSWSWLALALAVLLGAKPSACGPPPGPRPNILLLMADDLGIGDVGCYGNTTIRTPNIDRLAADGVRLTQHLAAAPLCTPSRAAFLTGRYPLRSGMVSSQGLRVLQWTAVSGGLPPSEITFAKILKAKGYTTGLIGKWHLGLSCASPDDHCHHPLNHGFDHFYGMPFSMMADCERWELSEKRAVLESRLDVCFQLVALATLTLTIGKLTHLIPGASWTLVIWSAVVCLLLFATSCLVGALIMHADCFLMRNHSIAEQPMRSQRTTPLMLQEVSSFVKRHKQGPFLLFVSFLHVHTPLVTTENFRGRSPHGLYGDNTEEMDWMVGQILETLDTEGLTNSTLVYFTSDHGGSLEARFGNNQYGGWNGIYKGWWTAGTCWPCSRGPRGTRTTSSSCTTARAFCTPPGGTSVTVSPPHAGARLGLCSPFLLPHAFLLFPRDCLYFLLGGIFLPIPGASFSCQSSCPGGMGMLAYGFVVVESLSRVKLFGDPMDCEAPPNPARLLCPWDSLGKNTGVGCHALLLQGIFPTQGSNTGVPCCSQIFYCLSH", "length": 548, "header": "tr|A0AAA9S2C2-1|A0AAA9SHX7_BOVIN Computationally mapped isoform of Arylsulfatase L OS=Bos taurus OX=9913 GN=ARSL PE=3 SV=1 CANONICAL=A0AAA9SHX7-1" }, "locus": { "chromosome": "X", "start_pos": 138665272, "end_pos": 138652290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092865.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092865.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080058.1" } ] } }, { "isoform_ac": "A0AAA9SH45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7/entry#A0AAA9SH45-1", "sequence": { "sequence": "MLRLEHSWTPNIDRLAADGVRLTQHLAAAPLCTPSRAAFLTGRYPLRSGMVSSQGLRVLQWTAVSGGLPPSEITFAKILKAKGYTTGLIGKWHLGLSCASPDDHCHHPLNHGFDHFYGMPFSMMADCERWELSEKRAVLESRLDVCFQLVALATLTLTIGKLTHLIPGASWTLVIWSAVVCLLLFATSCLVGALIMHADCFLMRNHSIAEQPMRSQRTTPLMLQEVSSFVKRHKQGPFLLFVSFLHVHTPLVTTENFRGRSPHGLYGDNTEEMDWMVGQILETLDTEGLTNSTLVYFTSDHGGSLEARFGNNQYGGWNGIYKGGAVWKVHFTTPIFQPDGAGACYGQIVCPCSGNRVTHHAPPLLFDLSRDPSEAHALTPDTEPSFHQVVETVARAVAAHRQTLIPVPLQLDAADNTWKPWLQPCCGRFPFCWCDRDADPR", "length": 441, "header": "tr|A0AAA9SH45-1|A0AAA9SH45_BOVIN Computationally mapped isoform of Arylsulfatase L OS=Bos taurus OX=9913 GN=ARSL PE=3 SV=1 CANONICAL=A0AAA9SHX7-1" }, "locus": { "chromosome": "X", "start_pos": 138665764, "end_pos": 138652290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118802.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118802.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083234.1" } ] } }, { "isoform_ac": "A0AAA9SHX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7/entry#A0AAA9SHX7-1", "sequence": { "sequence": "MLRLEHSWSWLALALAVLLGAKPSACGPPPGPRPNILLLMADDLGIGDVGCYGNTTIRTPNIDRLAADGVRLTQHLAAAPLCTPSRAAFLTGRYPLRSGMVSSQGLRVLQWTAVSGGLPPSEITFAKILKAKGYTTGLIGKWHLGLSCASPDDHCHHPLNHGFDHFYGMPFSMMADCERWELSEKRAVLESRLDVCFQLVALATLTLTIGKLTHLIPGASWTLVIWSAVVCLLLFATSCLVGALIMHADCFLMRNHSIAEQPMRSQRTTPLMLQEVSSFVKRHKQGPFLLFVSFLHVHTPLVTTENFRGRSPHGLYGDNTEEMDWMVGQILETLDTEGLTNSTLVYFTSDHGGSLEARFGNNQYGGWNGIYKGGKGMAGWEGGIRVPGIFRWPGVLPAGRVIHEPTSLMDIFPTVVHLAGGQVPQDRVVDGRDLLALLQGTARHSDHEFLMHYCESFLHAARWHQRDRGAVWKVHFTTPIFQPDGAGACYGQIVCPCSGNRVTHHAPPLLFDLSRDPSEAHALTPDTEPSFHQVVETVARAVAAHRQTLIPVPLQLDAADNTWKPWLQPCCGRFPFCWCDRDADPR", "length": 586, "header": "tr|A0AAA9SHX7-1|A0AAA9SHX7_BOVIN Isoform 1 of Arylsulfatase L OS=Bos taurus OX=9913 GN=ARSL PE=3 SV=1 CANONICAL=A0AAA9SHX7-1" }, "locus": { "chromosome": "Y", "start_pos": 1451652, "end_pos": 1438183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149080.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149080.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105980.1" } ] } }, { "isoform_ac": "A0AAA9TW59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7/entry#A0AAA9TW59-1", "sequence": { "sequence": "MLRLEHSWTPNIDRLAADGVRLTQHLAAAPLCTPSRAAFLTGRYPLRSGMVSSQGLRVLQWTAVSGGLPPSEITFAKILKAKGYTTGLIGKWHLGLSCASPDDHCHHPLNHGFDHFYGMPFSMMADCERWELSEKRAVLESRLDVCFQLVALATLTLTIGKLTHLIPGASWTLVIWSAVVCLLLFATSCLVGALIMHADCFLMRNHSIAEQPMRSQRTTPLMLQEVSSFVKRHKQGPFLLFVSFLHVHTPLVTTENFRGRSPHGLYGDNTEEMDWMVGQILETLDTEGLTNSTLVYFTSDHGGSLEARFGNNQYGGWNGIYKGGKGMAGWEGGIRVPGIFRWPGVLPAGRVIHEPTSLMDIFPTVVHLAGGQVPQDRVVDGRDLLALLQGTARHSDHEFLMHYCESFLHAARWHQRDRGAVWKVHFTTPIFQPDGAGACYGQIVCPCSGNRVTHHAPPLLFDLSRDPSEAHALTPDTEPSFHQVVETVARAVAAHRQTLIPVPLQLDAADNTWKPWLQPCCGRFPFCWCDRDADPR", "length": 536, "header": "tr|A0AAA9TW59-1|A0AAA9TW59_BOVIN Computationally mapped isoform of Arylsulfatase L OS=Bos taurus OX=9913 GN=ARSL PE=3 SV=1 CANONICAL=A0AAA9SHX7-1" }, "locus": { "chromosome": "X", "start_pos": 138665764, "end_pos": 138652290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125964.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125964.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101675.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101675.1" } ] } }, { "isoform_ac": "A0AAF6DM97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7/entry#A0AAF6DM97-1", "sequence": { "sequence": "MLRLEHSWSWLALALAVLLGAKPSACGPPPGPRPNILLLMADDLGIGDVGCYGNTTIRTPNIDRLAADGVRLTQHLAAAPLCTPSRAAFLTGRYPLRSGKWHLGLSCASPDDHCHHPLNHGFDHFYGMPFSMMADCERWELSEKRAVLESRLDVCFQLVALATLTLTIGKLTHLIPGASWTLVIWSAVVCLLLFATSCLVGALIMHADCFLMRNHSIAEQPMRSQRTTPLMLQEVSSFVKRHKQGPFLLFVSFLHVHTPLVTTENFRGRSPHGLYGDNTEEMDWMVGQILETLDTEGLTNSTLVYFTSDHGGSLEARFGNNQYGGWNGIYKGGKGMAGWEGGIRVPGIFRWPGVLPAGRVIHEPTSLMDIFPTVVHLAGGQVPQDRVVDGRDLLALLQGTARHSDHEFLMHYCESFLHAARWHQRDRGAVWKVHFTTPIFQPDGAGACYGQIVCPCSGNRVTHHAPPLLFDLSRDPSEAHALTPDTEPSFHQVVETVARAVAAHRQTLIPVPLQLDAADNTWKPWLQPCCGRFPFCWCDRDADPR", "length": 545, "header": "tr|A0AAF6DM97-1|A0AAF6DM97_BOVIN Computationally mapped isoform of Arylsulfatase L OS=Bos taurus OX=9913 GN=ARSL PE=3 SV=2 CANONICAL=A0AAA9SHX7-1" }, "locus": { "chromosome": "Y", "start_pos": 1451652, "end_pos": 1438183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050377.6", "url": "https://www.ensembl.org/id/ENSBTAT00000050377.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047083.6", "url": "https://www.ensembl.org/id/ENSBTAP00000047083.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX7" }, { "id": "PF00884", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00884" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfatase N-terminal", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 420, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 54, "end_pos": 56 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFT9-1", "uniprot_ac": "A0AAA9SFT9", "uniprot_id": "A0AAA9SFT9_BOVIN", "mass": { "chemical_mass": 40311.0, "monoisotopic_mass": 40311.0 }, "refseq": {}, "gene_names": [ { "name": "ADORA2B", "type": "recommended", "evidence": [ { "id": "A0AAA9SFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ] } ], "protein_names": [ { "name": "Adenosine receptor A2", "type": "recommended", "evidence": [ { "id": "A0AAA9SFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S309", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S309#function" }, { "database": "UniProtKB", "id": "RU201114", "url": "https://www.uniprot.org/uniprotkb/RU201114#function" }, { "database": "UniProtKB", "id": "ARBA00024642", "url": "https://www.uniprot.org/uniprotkb/ARBA00024642#function" }, { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADORA2B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9", "locus": { "chromosome": "19", "start_pos": 33481100, "end_pos": 33502754, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007581", "url": "https://www.ensembl.org/id/ENSBTAG00000007581" } ] } } ], "crossref": [ { "id": "A0AAA9SFT9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFT9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001435", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001435", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24246:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24246:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S309", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S309", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S309-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S309-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR56", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLEAQDAVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIISSTPPRKKQLEKRGPPLPGSDPLPELGGDFYISPKFKFGHDAGPQSENFTKVGYVTVFLYEVK", "length": 367, "header": "tr|A0AAA9SFT9-1|A0AAA9SFT9_BOVIN Isoform 1 of Adenosine receptor A2 OS=Bos taurus OX=9913 GN=ADORA2B PE=3 SV=1 CANONICAL=A0AAA9SFT9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S309-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9/entry#A0AAA9S309-1", "sequence": { "sequence": "GTLNSYPLIPAIIPEVGTCVLSGREEAQNGSSGASEGAGPIQRWAPAFPGVPACCVLLSTGAESRFCLQQYVFAVEKKKEKCSSPVSLPLLAPHLYLPLSRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIISRYILCRTHILKSGEGQVGSQPTLQLGL", "length": 321, "header": "tr|A0AAA9S309-1|A0AAA9SFT9_BOVIN Computationally mapped isoform of Adenosine receptor A2 OS=Bos taurus OX=9913 GN=ADORA2B PE=3 SV=1 CANONICAL=A0AAA9SFT9-1" }, "locus": { "chromosome": "19", "start_pos": 33501419, "end_pos": 33482818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129030.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129030.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078133.1" } ] } }, { "isoform_ac": "A0AAA9SFT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9/entry#A0AAA9SFT9-1", "sequence": { "sequence": "MPLEAQDAVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIISSTPPRKKQLEKRGPPLPGSDPLPELGGDFYISPKFKFGHDAGPQSENFTKVGYVTVFLYEVK", "length": 367, "header": "tr|A0AAA9SFT9-1|A0AAA9SFT9_BOVIN Isoform 1 of Adenosine receptor A2 OS=Bos taurus OX=9913 GN=ADORA2B PE=3 SV=1 CANONICAL=A0AAA9SFT9-1" }, "locus": { "chromosome": "19", "start_pos": 33502555, "end_pos": 33482104, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112417.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112417.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082743.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082743.1" } ] } }, { "isoform_ac": "A0AAF6YR56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9/entry#A0AAF6YR56-1", "sequence": { "sequence": "MPLEAQDAVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRQYVFAVEKKKEKCSSPVSLPLLAPHLYLPLSRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIISRYILCRTHILKSGEGQVGSQPTLQLGL", "length": 364, "header": "tr|A0AAF6YR56-1|A0AAF6YR56_BOVIN Computationally mapped isoform of Adenosine A2b receptor OS=Bos taurus OX=9913 GN=ADORA2B PE=3 SV=1 CANONICAL=A0AAA9SFT9-1" }, "locus": { "chromosome": "19", "start_pos": 33502555, "end_pos": 33482818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009974.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009974.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009974.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009974.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled adenosine receptor activity", "id": "GO:0001609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" }, { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "presynaptic modulation of chemical synaptic transmission", "id": "GO:0099171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099171", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 352, "end_pos": 354 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGJ3-1", "uniprot_ac": "A0AAA9SGJ3", "uniprot_id": "A0AAA9SGJ3_BOVIN", "mass": { "chemical_mass": 53502.0, "monoisotopic_mass": 53502.0 }, "refseq": {}, "gene_names": [ { "name": "COLQ", "type": "recommended", "evidence": [ { "id": "A0AAA9SGJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3" } ] } ], "protein_names": [ { "name": "Collagen like tail subunit of asymmetric acetylcholinesterase", "type": "synonym", "evidence": [ { "id": "A0AAA9SGJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COLQ", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3", "locus": { "chromosome": "1", "start_pos": 152481931, "end_pos": 152547921, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051541", "url": "https://www.ensembl.org/id/ENSBTAG00000051541" } ] } } ], "crossref": [ { "id": "A0AAA9SGJ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040193", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040193", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051541", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051541", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPW8", "url": "https://www.orthodb.org/?gene=E1BPW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MY98", "url": "https://www.orthodb.org/?gene=F1MY98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S3Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPW8", "url": "https://www.uniprot.org/uniprotkb/E1BPW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPW8-1", "url": "https://www.uniprot.org/uniprotkb/E1BPW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY98", "url": "https://www.uniprot.org/uniprotkb/F1MY98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY98-1", "url": "https://www.uniprot.org/uniprotkb/F1MY98-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLFLSQAAPHRPGHPPERREPCLPLPVPGSSGLASRPLASGAEAGIGQLPPQMPSRAGAGSAGGVTTLSQPPEGARCQCAWALPAMTGPPLSLAHLLTVSGLLCYSACCLAALPGLDQKRRGGPRACCLLTPPPPPLFPPPFFRGARGPLLSPDMKNLVLELETAQSPCAQGSLSSSGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPVGWPGPEGPRGEKGDLGLMGLPGSRGPMGSKGYPGSRGEKGFPGFPGMLGQKGEMGPKGEPGLAGHRGPTGRPGKRGKQGQKGDSGVTGPPGKPGPSGPPGRPGLPGPPGPPSAGQLVMGPKGERGFPGPPGRCLCGPPMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSFGWLPVQLTPVHPRDYPGDHRGSCGDGVLQPGEECDDGNADAGDDCIRCRRAYCGDGHRHRGVEDCDGADFGHLTCETYLPGSYGDLRCTPYCFIDSTPCRYFT", "length": 519, "header": "tr|A0AAA9SGJ3-1|A0AAA9SGJ3_BOVIN Isoform 1 of Collagen like tail subunit of asymmetric acetylcholinesterase OS=Bos taurus OX=9913 GN=COLQ PE=4 SV=1 CANONICAL=A0AAA9SGJ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3/entry#A0AAA9S3Q2-1", "sequence": { "sequence": "MLFLSQAAPHRPGHPPERREPCLPLPVPGSSGLASRPLASGAEAGIGQLPPQMPSRAGAGSAGGVTTLSQPPEGARCQCAWALPAMTGPPLSLAHLLTVSGLLCYSACCLAALPGLDQKRRGGPRACCLLTPPPPPLFPPPFFRGARGPLLSPDMKNLVLELETAQSPCAQGSLSSSGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPVGWPGPEGPRGEKGDLGLMGLPGSRGPMGSKGFPGFPGMLGQKGEMGPKGEPGLAGHRGPTGRPGKRGKQGQKGDSGVTGPPGKPGPSGPPGRPGLPGPPGPPSAGQLVMGPKGERGFPGPPGRCLCGPPMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSFGWLPVQLTPVHPRDYPGDHRGSCGDGVLQPGEECDDGNADAGDDCIRCRRAYCGDGHRHRGVEDCDGADFGHLTCETYLPGSYGDLRCTPYCFIDSTPCRYFT", "length": 510, "header": "tr|A0AAA9S3Q2-1|A0AAA9SGJ3_BOVIN Computationally mapped isoform of Collagen like tail subunit of asymmetric acetylcholinesterase OS=Bos taurus OX=9913 GN=COLQ PE=4 SV=1 CANONICAL=A0AAA9SGJ3-1" }, "locus": { "chromosome": "1", "start_pos": 152524650, "end_pos": 152483267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112252.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112252.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079731.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079731.1" } ] } }, { "isoform_ac": "A0AAA9SGJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3/entry#A0AAA9SGJ3-1", "sequence": { "sequence": "MLFLSQAAPHRPGHPPERREPCLPLPVPGSSGLASRPLASGAEAGIGQLPPQMPSRAGAGSAGGVTTLSQPPEGARCQCAWALPAMTGPPLSLAHLLTVSGLLCYSACCLAALPGLDQKRRGGPRACCLLTPPPPPLFPPPFFRGARGPLLSPDMKNLVLELETAQSPCAQGSLSSSGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPVGWPGPEGPRGEKGDLGLMGLPGSRGPMGSKGYPGSRGEKGFPGFPGMLGQKGEMGPKGEPGLAGHRGPTGRPGKRGKQGQKGDSGVTGPPGKPGPSGPPGRPGLPGPPGPPSAGQLVMGPKGERGFPGPPGRCLCGPPMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSFGWLPVQLTPVHPRDYPGDHRGSCGDGVLQPGEECDDGNADAGDDCIRCRRAYCGDGHRHRGVEDCDGADFGHLTCETYLPGSYGDLRCTPYCFIDSTPCRYFT", "length": 519, "header": "tr|A0AAA9SGJ3-1|A0AAA9SGJ3_BOVIN Isoform 1 of Collagen like tail subunit of asymmetric acetylcholinesterase OS=Bos taurus OX=9913 GN=COLQ PE=4 SV=1 CANONICAL=A0AAA9SGJ3-1" }, "locus": { "chromosome": "1", "start_pos": 152524650, "end_pos": 152483267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135853.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135853.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082811.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082811.1" } ] } }, { "isoform_ac": "A0AAA9TEW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3/entry#A0AAA9TEW3-1", "sequence": { "sequence": "MLVLHPVTLGIYLQLFFRFIVSQPTFLTSVLPISAAALPGLDQKRRGGPRACCLLTPPPPPLFPPPFFRGARGPLLSPDMKNLVLELETAQSPCAQGSLSSSGPPGPQGPPGLPGKTGPKGEKGSLVDQEGSQGLQPAPGGIRTSEAAKPGQVSSQPHPAVHQRNPPKPQPAAPNDSHCRFD", "length": 182, "header": "tr|A0AAA9TEW3-1|A0AAA9TEW3_BOVIN Computationally mapped isoform of Collagen like tail subunit of asymmetric acetylcholinesterase OS=Bos taurus OX=9913 GN=COLQ PE=4 SV=2 CANONICAL=A0AAA9SGJ3-1" }, "locus": { "chromosome": "1", "start_pos": 152547849, "end_pos": 152510214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134945.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134945.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095371.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095371.2" } ] } }, { "isoform_ac": "E1BPW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3/entry#E1BPW8-1", "sequence": { "sequence": "MLVLHPVTLGIYLQLFFRFIVSQPTFLTSVLPISAAALPGLDQKRRGGPRACCLLTPPPPPLFPPPFFRGARGPLLSPDMKNLVLELETAQSPCAQGSLSSSGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPVGWPGPEGPRGEKGDLGLMGLPGSRGPMGSKGYPGSRGEKVRACLSRLPGASQGFPGFPGMLGQKGEMGPKGEPGLAGHRGPTGRPGKRGKQGQKGDSGVTGPPGKPGPSGPPGRPGLPGPPGQLVMGPKGERGFPGPPGRCLCGPPMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSFGWLPVQLTPVHPRDYPGDHRGSCGDGVLQPGEECDDGNADAGDDCIRCRRAYCGDGHRHRGVEDCDGADFGHLTCETYLPGSYGDLRCTPYCFIDSTPCRYFT", "length": 452, "header": "tr|E1BPW8-1|A0AAA9SGJ3_BOVIN Computationally mapped isoform of Collagen like tail subunit of asymmetric acetylcholinesterase OS=Bos taurus OX=9913 GN=COLQ PE=4 SV=5 CANONICAL=A0AAA9SGJ3-1" }, "locus": { "chromosome": "1", "start_pos": 152547849, "end_pos": 152483267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061345.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061345.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053329.5", "url": "https://www.ensembl.org/id/ENSBTAP00000053329.5" } ] } }, { "isoform_ac": "F1MY98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3/entry#F1MY98-1", "sequence": { "sequence": "MLVLHPVTLGIYLQLFFRFIVSQPTFLTSVLPISAAALPGLDQKRRGGPRACCLLTPPPPPLFPPPFFRGARGPLLSPDMKNLVLELETAQSPCAQGSLSSSGPPGPQGPPGLPGKTGPKTEATASLCPLLSQGLQPAPGGIRTSEAAKPGQVSSQPHPAVHQRNPPKPQPAAPNDSHCRFD", "length": 182, "header": "tr|F1MY98-1|A0AAA9SGJ3_BOVIN Computationally mapped isoform of Collagen like tail subunit of asymmetric acetylcholinesterase OS=Bos taurus OX=9913 GN=COLQ PE=4 SV=4 CANONICAL=A0AAA9SGJ3-1" }, "locus": { "chromosome": "1", "start_pos": 152547849, "end_pos": 152510214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030369.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030369.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030353.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030353.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of synaptic transmission, cholinergic", "id": "GO:0032223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3" } ], "pmid": "" }, { "name": "protein localization to synapse", "id": "GO:0035418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035418", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFG0-1", "uniprot_ac": "A0AAA9SFG0", "uniprot_id": "A0AAA9SFG0_BOVIN", "mass": { "chemical_mass": 126977.0, "monoisotopic_mass": 126977.0 }, "refseq": { "ac": "XP_002690899", "name": "unconventional myosin-Ie", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690899" }, "gene_names": [ { "name": "MYO1E", "type": "recommended", "evidence": [ { "id": "A0AAA9SFG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ] }, { "name": "MYO1E", "type": "synonym", "evidence": [ { "id": "XP_002690899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690899" } ] } ], "protein_names": [ { "name": "Myosin IE", "type": "synonym", "evidence": [ { "id": "A0AAA9SFG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#names_and_taxonomy" } ] }, { "name": "unconventional myosin-Ie", "type": "synonym", "evidence": [ { "id": "XP_002690899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690899" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYO1E", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0", "locus": { "chromosome": "10", "start_pos": 51178538, "end_pos": 50957741, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021538", "url": "https://www.ensembl.org/id/ENSBTAG00000021538" } ] } } ], "crossref": [ { "id": "A0AAA9SFG0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021538", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021538", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01378", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01378", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11827", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11827", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523485", "url": "https://www.ncbi.nlm.nih.gov/gene/523485", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523485", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523485", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NDQENQC", "url": "https://omabrowser.org/oma/group/NDQENQC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRW2", "url": "https://www.orthodb.org/?gene=A0A3Q1MRW2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MQ65", "url": "https://www.orthodb.org/?gene=F1MQ65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140:SF341", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140:SF341", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690899", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690899", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRW2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S635", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S635", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S635-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S635-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1D7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ65", "url": "https://www.uniprot.org/uniprotkb/F1MQ65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ65-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITENAIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1108, "header": "tr|A0AAA9SFG0-1|A0AAA9SFG0_BOVIN Isoform 1 of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0A3Q1MRW2-1", "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITENAIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDVNYISGRKCNRQCCWPRR", "length": 1102, "header": "tr|A0A3Q1MRW2-1|A0A3Q1MRW2_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=2 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51176349, "end_pos": 50958102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076532.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076532.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072619.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072619.2" } ] } }, { "isoform_ac": "A0AAA9S4H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9S4H4-1", "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITENAIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGGGPLQEISRYSRDESNWKLEKQKNIESAQWLGFWPCHKREIDRKMSSSHILAQADTKPRNFWHPFPHFQ", "length": 1096, "header": "tr|A0AAA9S4H4-1|A0AAA9SFG0_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51163735, "end_pos": 50958102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092860.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092860.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080059.1" } ] } }, { "isoform_ac": "A0AAA9S635-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9S635-1", "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITENAIVENLKKRYMDDYIFPQVYIYPLPLGFPRGSDDKESACSAGDWVHPSAGKIPWRREWQPTPVFLPGESHGQRSLAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1137, "header": "tr|A0AAA9S635-1|A0AAA9SFG0_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 50958102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118032.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118032.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081400.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081400.1" } ] } }, { "isoform_ac": "A0AAA9SFG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9SFG0-1", "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITENAIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1108, "header": "tr|A0AAA9SFG0-1|A0AAA9SFG0_BOVIN Isoform 1 of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 50958102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127055.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127055.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081193.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081193.1" } ] } }, { "isoform_ac": "A0AAA9SSZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9SSZ4-1", "sequence": { "sequence": "MRKELNLPAMRITSLERMCFNSLKVMIYFYNTLVIKFTTLPEEQNLNYLMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1093, "header": "tr|A0AAA9SSZ4-1|A0AAA9SSZ4_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 51060845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124839.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124839.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088471.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088471.1" } ] } }, { "isoform_ac": "A0AAA9SWF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9SWF5-1", "sequence": { "sequence": "MIKNLPAVQETGFIPQLGRSPGEENGNRLQYSCLENLMDRGAFGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1040, "header": "tr|A0AAA9SWF5-1|A0AAA9SWF5_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 51059527, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089624.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089624.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089654.1" } ] } }, { "isoform_ac": "A0AAA9T2N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9T2N0-1", "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITENAIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGSSSHILAQADTKPRNFWHPFPHFQ", "length": 1051, "header": "tr|A0AAA9T2N0-1|A0AAA9T2N0_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51163735, "end_pos": 50958102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112836.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112836.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090704.1" } ] } }, { "isoform_ac": "A0AAA9TP22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9TP22-1", "sequence": { "sequence": "MLTCVRFLETPMDCSPSRLLCPWKFPAMRITSLERMCFNSLKVMIYFYNTLVIKFTTLPEEQNLNYLMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1111, "header": "tr|A0AAA9TP22-1|A0AAA9TP22_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 51068561, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129324.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129324.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100121.1" } ] } }, { "isoform_ac": "A0AAA9U1D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#A0AAA9U1D7-1", "sequence": { "sequence": "MRKELNLPAMRITSLERMCFNSLKVMIYFYNTLVIKFTTLPEEQNLNYLAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1078, "header": "tr|A0AAA9U1D7-1|A0AAA9U1D7_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=1 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 51060845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111986.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111986.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103891.1" } ] } }, { "isoform_ac": "F1MQ65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0/entry#F1MQ65-1", "sequence": { "sequence": "MRITSLERMCFNSLKVMIYFYNTLVIKFTTLPEEQNLNYLAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKHGLGITTMDYYYYLSLSGSYTVDGIDDKKDFQETLHAMNVIGIFAEEQALVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESINVTLNVEQACYTRDALAKALHSRVFDFLVDSINKAMEKDHQEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIDYFNNKVVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGNHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSEQPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPSWKGDEKQGVLHLLQSVNMDSDQFQLGKSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASNLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKSVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRRIEMERILSVSLSTMQDDLFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLEIKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPRNSRPTRRNTIQSRDYSSRTHNANYPMRAAPLPPGLHQNGVIKNQFVPYPYAAGNQRSNQKSLYTSMARPPLPQQQSIGSDRASQALESLDFLKVPDQGAAGARRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1069, "header": "tr|F1MQ65-1|F1MQ65_BOVIN Computationally mapped isoform of Myosin IE OS=Bos taurus OX=9913 GN=MYO1E PE=3 SV=4 CANONICAL=A0AAA9SFG0-1" }, "locus": { "chromosome": "10", "start_pos": 51177534, "end_pos": 51068910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061089.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061089.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053355.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053355.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523485", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523485", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P34092-1", "protein_name": "Myosin IB heavy chain", "gene_name": "myoB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKKVQAKQGTDDLVMLPKVSEDEICENLKKRYMNDFIYTNIGPVLISVNPFRNLNNSGPDFIEAYRGKHAQEVPPHVYQLAESAYRAMKNDQENQCVIISGESGAGKTEAAKLIMGYVSAISGSTEKVEYVKHVILESNPLLEAFGNAKTLRNNNSSRFGKYFEIQFDKAGDPVGGKIYNYLLEKSRVVYQNPGERNFHIFYQLLAGASAQEKRDYVLSSPESYYYLNQSQCYTVDGINDVSDYAEVRQAMDTIGLTAQEQSDIIRIVACVLHIGNIYFIEDDKGNAAIYDPNALELAASMLCIDSATLQNAILFRVINTGGAGGAGNRRSTYNVPQNVEQANGTRDALARTIYDRMFSWLVERVNQSLSYYKSPYQNVIGILDIFGFEIFEKNGFEQFCINFVNEKLQQFFIELTLKAEQEEYVREGIKWEPIKYFNNQIVCDLIEGKSPPGIFSLLDDICSTLHAQSTGTDQKFLEKMAGIYDGHLHWRGMTGAFAIKHYAGEVTYEAEGFSDKNKDTLFFDLIEAIQCSKMPFLASLFNEDTGSLQKKRPTTAGFKIKTSAGELMKALSQCTPHYIRCIKPNETKKAKDWENSRVKHQVQYLGLLENVRVRRAGFAYRNTFDKVLKRYKKLSSKTWGIWGEWKGDAIEGCKTIFQDMNLEAGQWQLGKTKVFIRHPETVFLLEEALDKKDFDCTAKIQKAFRNWKAKKHSLEQRAQIAHMFKDKKERQRNSIDRKFTSDYIDFENQFGLQEAMQNAHKKERVVFADTVIKIDRRAKQKNYEMVLTDQALYFVEKSIKKKVLVHTLIRRVGLREIKGVSISTLSDNVIVFHLPEHDQVIENDKKTEIIIVLVEYFKAIGGGSLNVQFSDRINYTLKKGEQKEISFQKSEQCPTLVVKKGGKGLIGTIASGLPSSTDSTPKNYNPNSMSQASSRPAPQQSAGRGRGMPQGAGQPQPQQPQQQQRPMPQPQQGGGARPMPQPQQGGGARPMGAPQQGGAPQQGAGRQLPQPTQQGGAPGGRGAPMGRGAPGGGPAGAGGRPLPTVAKPAPQPSRPTAKALYDYDASSTDELSFKEGDIIFIVQKDNGGWTQGELKSGQKGWAPTNYLQYN", "length": 1111 }, "evidence": [ { "id": "A0AAA9SFG0", "url": "https://omabrowser.org/oma/group/A0AAA9SFG0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q04439-1", "protein_name": "Myosin-5", "gene_name": "MYO5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAILKRGARKKVHQEPAKRSANIKKATFDSSKKKEVGVSDLTLLSKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYTDAVMNEYKGKNRLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASSTHTESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVVSQIKNERNFHIFYQFTKGASDAYRQTFGVQKPEQYVYTAAAGCISAETIDDLQDYQETLKAMRVIGLGQEEQDQIFRMLAAILWIGNVSFIENEEGNAQVRDTSVTDFVAYLLQIDSQLLIKSLVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGAEKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVVCDLIEARRPPGIFAAMNDSVATAHADSNAADQAFAQRLNLFTTNPHFDLRSNKFVIKHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVDRESKRRPPTAGDKIIKSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFEKFVERFYLLSPHCSYAGDYTWQGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLFALEHMRDRYWHNMAARIQRAWRRFLQRRIDAATKIQRTIRERKEGNKYEKLRDYGTKVLGGRKERRSMSLLGYRAFMGDYLSCNESKSKGAYIKRQVSIKEKVIFSIHGEALHTKFGRSAQRLKKTFLLTPTTLYIVGQTLVQNAMTYTQDYKIDVRNIQAVSLTNLQDDWVAIKLASSGQPDPLINTYFKTELITHLKRLNDKIQIKIGSAIEYQKKPGKLHSVKCQINESAPKYGDIYKSSTISVRRGNPPNSQVHKKPRKKSSISSGYHASSSQATRRPVSIAAAQHVPTAPASRHSKKPAPPPPGMQNKAATRRSVPNPASTLTASQSNARPSPPTAATRATPAATPAAAAMGSGRQANIPPPPPPPPPSSKPKEPMFEAAYDFPGSGSPSELPLKKGDVIYITREEPSGWSLGKLLDGSKEGWVPTAYMKPHSGNNNIPTPPQNRDVPKPVLNSVQHDNTSANVIPAAAQASLGDGLANALAARANKMRLESDDEEANEDEEEDDW", "length": 1219 }, "evidence": [ { "id": "A0AAA9SFG0", "url": "https://omabrowser.org/oma/group/A0AAA9SFG0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q12965-1", "protein_name": "Unconventional myosin-Ie", "gene_name": "MYO1E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1108 }, "evidence": [ { "id": "A0AAA9SFG0", "url": "https://omabrowser.org/oma/group/A0AAA9SFG0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q63356-1", "protein_name": "Unconventional myosin-Ie", "gene_name": "Myo1e", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNINFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREDASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADIVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLTKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFYQGFGDLAILKPSNKVLQVSIGPGLPKNARPTRRNTVSSRGYSGGTNNNYPMRAAPAPPGCHRNGLTRNQFVHPPRASGNQRSNQKSLYTSMARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDVIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI", "length": 1107 }, "evidence": [ { "id": "A0AAA9SFG0", "url": "https://omabrowser.org/oma/group/A0AAA9SFG0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "clathrin-coated endocytic vesicle", "id": "GO:0045334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "glomerular filtration", "id": "GO:0003094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "podocyte development", "id": "GO:0072015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "glomerular basement membrane development", "id": "GO:0032836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032836", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" }, { "name": "glomerulus development", "id": "GO:0032835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032835", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" }, { "id": "PS51456", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51456" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin motor", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 692, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 1051, "end_pos": 1108, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG0" }, { "id": "PS51757", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51757" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TH1", "eco_id": "ECO_0000259", "start_pos": 730, "end_pos": 922, "start_aa": "Lys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 340, "end_pos": 342 }, { "start_pos": 590, "end_pos": 592 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGA3-1", "uniprot_ac": "A0AAA9SGA3", "uniprot_id": "A0AAA9SGA3_BOVIN", "mass": { "chemical_mass": 17745.0, "monoisotopic_mass": 17745.0 }, "refseq": {}, "gene_names": [ { "name": "CLPS", "type": "recommended", "evidence": [ { "id": "A0AAA9SGA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ] } ], "protein_names": [ { "name": "Colipase", "type": "synonym", "evidence": [ { "id": "A0AAA9SGA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S509#function" }, { "database": "UniProtKB", "id": "ARBA00003508", "url": "https://www.uniprot.org/uniprotkb/ARBA00003508#function" }, { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3#function" }, { "database": "UniProtKB", "id": "A0AAA9SNM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM6#function" }, { "database": "UniProtKB", "id": "A0AAA9SUL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL7#function" }, { "database": "UniProtKB", "id": "A0AAA9TKS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS7#function" }, { "database": "UniProtKB", "id": "A0AAA9TWV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWV1#function" }, { "database": "UniProtKB", "id": "A0AAA9TZV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZV3#function" }, { "database": "UniProtKB", "id": "A0AAF6Z3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3N2#function" } ] }, { "annotation": "Enterostatin has a biological activity as a satiety signal.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S509#function" }, { "database": "UniProtKB", "id": "ARBA00002722", "url": "https://www.uniprot.org/uniprotkb/ARBA00002722#function" }, { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3#function" }, { "database": "UniProtKB", "id": "A0AAA9SNM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM6#function" }, { "database": "UniProtKB", "id": "A0AAA9SUL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL7#function" }, { "database": "UniProtKB", "id": "A0AAA9TKS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS7#function" }, { "database": "UniProtKB", "id": "A0AAA9TWV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWV1#function" }, { "database": "UniProtKB", "id": "A0AAA9TZV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZV3#function" }, { "database": "UniProtKB", "id": "A0AAF6Z3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3N2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLPS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23011", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23011", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10041", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10041", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10041:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10041:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02740", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02740", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S509", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S509-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S509-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z3N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z3N2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFPQEGTARALWIRNPVCRFLTQGQAWVQRGRDGPAITCKSLWREEFPRRWSSTFTGSLKDWGTQGGLETPFGGPQDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 161, "header": "tr|A0AAA9SGA3-1|A0AAA9SGA3_BOVIN Isoform 1 of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S509-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9S509-1", "sequence": { "sequence": "MEITNLNNLSKCVQLIMDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 101, "header": "tr|A0AAA9S509-1|A0AAA9SGA3_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9761962, "end_pos": 9758407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133538.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133538.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080272.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080272.1" } ] } }, { "isoform_ac": "A0AAA9SGA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9SGA3-1", "sequence": { "sequence": "MAFPQEGTARALWIRNPVCRFLTQGQAWVQRGRDGPAITCKSLWREEFPRRWSSTFTGSLKDWGTQGGLETPFGGPQDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 161, "header": "tr|A0AAA9SGA3-1|A0AAA9SGA3_BOVIN Isoform 1 of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9759639, "end_pos": 9758407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123800.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123800.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084399.1" } ] } }, { "isoform_ac": "A0AAA9SNM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9SNM6-1", "sequence": { "sequence": "PTLTSPSLNASGLLTYLVLDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 103, "header": "tr|A0AAA9SNM6-1|A0AAA9SNM6_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9760136, "end_pos": 9758407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117101.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117101.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087932.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087932.1" } ] } }, { "isoform_ac": "A0AAA9SUL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9SUL7-1", "sequence": { "sequence": "KLAVFHFLGWGRGALLQWPALQGKPLHPTPEHTQAAVPFPAFTLGQQRPKGPFHPQPGLTTAQAHTWPWVGDRDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 157, "header": "tr|A0AAA9SUL7-1|A0AAA9SUL7_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9761854, "end_pos": 9758407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113162.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113162.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089044.1" } ] } }, { "isoform_ac": "A0AAA9TKS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9TKS7-1", "sequence": { "sequence": "FDPWVGKIPWRRAWQPTPVSLPGESQGHRSLDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 115, "header": "tr|A0AAA9TKS7-1|A0AAA9TKS7_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9760001, "end_pos": 9758407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099049.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099049.1" } ] } }, { "isoform_ac": "A0AAA9TWV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9TWV1-1", "sequence": { "sequence": "MEKVLILLLVALAVAYAVPDPRGIIINLDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFSVTTLSLQTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE", "length": 120, "header": "tr|A0AAA9TWV1-1|A0AAA9TWV1_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9760669, "end_pos": 9758407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102836.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102836.1" } ] } }, { "isoform_ac": "A0AAA9TZV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAA9TZV3-1", "sequence": { "sequence": "MEKVLILLLVALAVAYAVPDPRGIIINLDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATEVC", "length": 114, "header": "tr|A0AAA9TZV3-1|A0AAA9TZV3_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9760669, "end_pos": 9755858, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104937.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104937.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102289.1" } ] } }, { "isoform_ac": "A0AAF6Z3N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3/entry#A0AAF6Z3N2-1", "sequence": { "sequence": "MEKVLILLLVALAVAYAVPDPRGIIINLDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATELTSPYLH", "length": 119, "header": "tr|A0AAF6Z3N2-1|A0AAF6Z3N2_BOVIN Computationally mapped isoform of Colipase OS=Bos taurus OX=9913 GN=CLPS PE=4 SV=1 CANONICAL=A0AAA9SGA3-1" }, "locus": { "chromosome": "23", "start_pos": 9760669, "end_pos": 9756820, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022391.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022391.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022391.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022391.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ], "pmid": "" }, { "name": "lipase binding", "id": "GO:0035473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035473", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ], "pmid": "" }, { "name": "digestion", "id": "GO:0007586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007586", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" }, { "id": "PF02740", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02740" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Colipase C-terminal", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 155, "start_aa": "Asn", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGA3" }, { "id": "PF01114", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01114" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Colipase N-terminal", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 109, "start_aa": "Asp", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGV8-1", "uniprot_ac": "A0AAA9SGV8", "uniprot_id": "A0AAA9SGV8_BOVIN", "mass": { "chemical_mass": 111315.0, "monoisotopic_mass": 111315.0 }, "refseq": {}, "gene_names": [ { "name": "EGFLAM", "type": "recommended", "evidence": [ { "id": "A0AAA9SGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ] } ], "protein_names": [ { "name": "Pikachurin", "type": "recommended", "evidence": [ { "id": "A0AAA9SGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#names_and_taxonomy" } ] }, { "name": "EGF-like, fibronectin type-III and laminin G-like domain-containing protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM6#function" }, { "database": "UniProtKB", "id": "ARBA00059801", "url": "https://www.uniprot.org/uniprotkb/ARBA00059801#function" }, { "database": "UniProtKB", "id": "A0A3Q1LPC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC1#function" }, { "database": "UniProtKB", "id": "F1N606", "url": "https://www.uniprot.org/uniprotkb/F1N606#function" }, { "database": "UniProtKB", "id": "A0AAA9S607", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S607#function" }, { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EGFLAM", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8", "locus": { "chromosome": "20", "start_pos": 35967740, "end_pos": 36161759, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019595", "url": "https://www.ensembl.org/id/ENSBTAG00000019595" } ] } } ], "crossref": [ { "id": "A0AAA9SGV8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGV8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPC1", "url": "https://www.orthodb.org/?gene=A0A3Q1LPC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N606", "url": "https://www.orthodb.org/?gene=F1N606", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15036:SF88", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15036:SF88", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00054", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00054", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25016", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25016", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LPC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPC1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S607", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S607", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S607-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S607-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N606", "url": "https://www.uniprot.org/uniprotkb/F1N606", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N606-1", "url": "https://www.uniprot.org/uniprotkb/F1N606-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLIRGVLLRLLLLASSLGPGAAPLRSALRKQGKVGPPLDIILDALNCSAFSIQWKMPRHPPSPIMGYTVFYSEVGIDKSLQERSYGVPPGLDTPTSEEVIGDLKPGTEYRVSMAAYSQTGKGRLSSPQHVTTLPQDSCLPPTAPQQPHVIVVSDSEVALSWKPGESEGSSPIQYYSVEFTRPDFDKSWTSIREQIQMDSMVIKGLDPDTNYQFAVRAVNPHGSSPRSQPSSTIRTARPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFFVESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETVCSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQALTVNGKRLDLRPWPLGKVLSGADVGECSSGICDEASCINGGTCMASKADSYICLCPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLLYSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELRVSRTAKNGILQVDKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHVKHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKECGNYCLNTITEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK", "length": 1017, "header": "tr|A0AAA9SGV8-1|A0AAA9SGV8_BOVIN Isoform 1 of Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=4 SV=1 CANONICAL=A0AAA9SGV8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#A0A3Q1LPC1-1", "sequence": { "sequence": "MLSICKHTLLHLVLSVLMVGCKVGPPLDIILDALNCSAFSIQWKMPRHPPSPIMGYTVFYSEVGIDKSLQERSYGVPPGLDTPTSGRLDHQMIFEEVIGDLKPGTEYRVSMAAYSQTGKGRLSSPQHVTTLPQDSCLPPTAPQQPHVIVVSDSEVALSWKPGESEGSSPIQYYSVEFTRPDFDKSWTSIREQIQMDSMVIKGLDPDTNYQFAVRAVNPHGSSPRSQPSSTIRTARPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFFVESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETVCSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQALTVNGKRLDLRPWPLGKVLSGADVGECSSGICDEASCINGGTCMASKADSYICLCPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLLYSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELRVSRTAKNGILQVDKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHVKHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKAITEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK", "length": 1006, "header": "tr|A0A3Q1LPC1-1|A0A3Q1LPC1_BOVIN Computationally mapped isoform of Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=4 SV=2 CANONICAL=A0AAA9SGV8-1" }, "locus": { "chromosome": "20", "start_pos": 36093599, "end_pos": 35968746, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069022.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069022.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058765.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058765.2" } ] } }, { "isoform_ac": "A0AAA9S607-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#A0AAA9S607-1", "sequence": { "sequence": "MDLIRGVLLRLLLLASSLGPGAAPLRSALRKQGKVGPPLDIILDALNCSAFSIQWKMPRHPPSPIMGYTVFYSEVGIDKSLQERSYGVPPGLDTPTSGRLDHQMIFEEVIGDLKPGTEYRVSMAAYSQTGKGRLSSPQHVTTLPQDSCLPPTAPQQPHVIVVSDSEVALSWKPGESEGSSPIQYYSVEFTRPDFDKSWTSIREQIQMDSMVIKGLDPDTNYQFAVRAVNPHGSSPRSQPSSTIRTARDLPNLRITHGSPELQADSLSSEPQGSLRVRPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFFVESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETVCSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQALTVNGKRLDLRPWPLGKVLSGADVGECSSGICDEASCINGGTCMASKADSYICLCPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLLYSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELRVSRTAKNGILQVDKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHVKHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKAITEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK", "length": 1048, "header": "tr|A0AAA9S607-1|A0AAA9SGV8_BOVIN Computationally mapped isoform of Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=4 SV=1 CANONICAL=A0AAA9SGV8-1" }, "locus": { "chromosome": "20", "start_pos": 36161735, "end_pos": 35968746, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106912.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106912.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080655.1" } ] } }, { "isoform_ac": "A0AAA9SGV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#A0AAA9SGV8-1", "sequence": { "sequence": "MDLIRGVLLRLLLLASSLGPGAAPLRSALRKQGKVGPPLDIILDALNCSAFSIQWKMPRHPPSPIMGYTVFYSEVGIDKSLQERSYGVPPGLDTPTSEEVIGDLKPGTEYRVSMAAYSQTGKGRLSSPQHVTTLPQDSCLPPTAPQQPHVIVVSDSEVALSWKPGESEGSSPIQYYSVEFTRPDFDKSWTSIREQIQMDSMVIKGLDPDTNYQFAVRAVNPHGSSPRSQPSSTIRTARPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFFVESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETVCSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQALTVNGKRLDLRPWPLGKVLSGADVGECSSGICDEASCINGGTCMASKADSYICLCPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLLYSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELRVSRTAKNGILQVDKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHVKHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKECGNYCLNTITEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK", "length": 1017, "header": "tr|A0AAA9SGV8-1|A0AAA9SGV8_BOVIN Isoform 1 of Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=4 SV=1 CANONICAL=A0AAA9SGV8-1" }, "locus": { "chromosome": "20", "start_pos": 36161735, "end_pos": 35968746, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131710.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131710.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085427.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085427.1" } ] } }, { "isoform_ac": "A0AAA9SKM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#A0AAA9SKM6-1", "sequence": { "sequence": "MHLGPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFFVESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETVCSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQALTVNGKRLDLRPWPLGKVLSGADVGECSSGICDEASCINGGTCMASKADSYICLCPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLLYSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELRVSRTAKNGILQVDKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHVKHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKAITEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK", "length": 775, "header": "tr|A0AAA9SKM6-1|A0AAA9SKM6_BOVIN Computationally mapped isoform of Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=4 SV=2 CANONICAL=A0AAA9SGV8-1" }, "locus": { "chromosome": "20", "start_pos": 36032089, "end_pos": 35968746, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103818.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103818.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086892.1" } ] } }, { "isoform_ac": "F1N606-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8/entry#F1N606-1", "sequence": { "sequence": "MDLIRGVLLRLLLLASSLGPGAAPLRSALRKQGKVGPPLDIILDALNCSAFSIQWKMPRHPPSPIMGYTVFYSEVGIDKSLQERSYGVPPGLDTPTSGRLDHQMIFEEVIGDLKPGTEYRVSMAAYSQTGKGRLSSPQHVTTLPQDSCLPPTAPQQPHVIVVSDSEVALSWKPGESEGSSPIQYYSVEFTRPDFDKSWTSIREQIQMDSMVIKGLDPDTNYQFAVRAVNPHGSSPRSQPSSTIRTARPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFFVESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETVCSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQALTVNGKRLDLRPWPLGKVLSGADVGECSSGICDEASCINGGTCMASKADSYICLCPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLLYSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELRVSRTAKNGILQVDKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHVKHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKAITEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK", "length": 1018, "header": "tr|F1N606-1|F1N606_BOVIN Computationally mapped isoform of Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=4 SV=4 CANONICAL=A0AAA9SGV8-1" }, "locus": { "chromosome": "20", "start_pos": 36161735, "end_pos": 35968746, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026111.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026111.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026111.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026111.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 312, "start_aa": "Thr", "end_pos": 312, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr312", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 326, "start_aa": "Thr", "end_pos": 326, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr326", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "glycosaminoglycan binding", "id": "GO:0005539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "presynaptic active zone", "id": "GO:0048786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "interstitial matrix", "id": "GO:0005614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005614", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "photoreceptor ribbon synapse", "id": "GO:0098684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098684", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "trans-synaptic protein complex", "id": "GO:0098820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098820", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 917, "end_pos": 919, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 343, "end_pos": 381, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 136, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGV8" }, { "id": "PS50025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin G", "eco_id": "ECO_0000259", "start_pos": 386, "end_pos": 564, "start_aa": "Ile", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 312, 326 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 47, "end_pos": 49 }, { "start_pos": 489, "end_pos": 491 }, { "start_pos": 917, "end_pos": 919 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFG5-1", "uniprot_ac": "A0AAA9SFG5", "uniprot_id": "A0AAA9SFG5_BOVIN", "mass": { "chemical_mass": 165388.0, "monoisotopic_mass": 165388.0 }, "refseq": {}, "gene_names": [ { "name": "CLASP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SFG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ] } ], "protein_names": [ { "name": "CLIP-associating protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SFG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#names_and_taxonomy" } ] }, { "name": "Cytoplasmic linker-associated protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SFG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TM50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM50#function" }, { "database": "UniProtKB", "id": "ARBA00055763", "url": "https://www.uniprot.org/uniprotkb/ARBA00055763#function" }, { "database": "UniProtKB", "id": "E1BQ15", "url": "https://www.uniprot.org/uniprotkb/E1BQ15#function" }, { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5#function" }, { "database": "UniProtKB", "id": "A0AAA9S6I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6I3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLASP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5", "locus": { "chromosome": "22", "start_pos": 7733640, "end_pos": 7909236, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011333", "url": "https://www.ensembl.org/id/ENSBTAG00000011333" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011333", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011333", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057546", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057546", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BQ15", "url": "https://www.orthodb.org/?gene=E1BQ15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21567", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21567", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21567:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21567:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12348", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12348", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S6I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6I3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ15", "url": "https://www.uniprot.org/uniprotkb/E1BQ15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ15-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRSMEYFSAQVQQKDVGGRLQVGQELLLYLGAPGAIPDLEEDLARLSKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALVDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVLSKLVPHLCILFGDSNSQVRDAAILAMVEIYRHVGEKVRVDLYKRGIPPARLEMILAKFDEVQNSGGMILSACKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKTVKPALRDQLHSFWSSKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1509, "header": "tr|A0AAA9SFG5-1|A0AAA9SFG5_BOVIN Isoform 1 of CLIP-associating protein 1 OS=Bos taurus OX=9913 GN=CLASP2 PE=3 SV=1 CANONICAL=A0AAA9SFG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#A0AAA9S6I3-1", "sequence": { "sequence": "MEPRSMEYFSAQVQQKDVGGRLQVGQELLLYLGAPGAIPDLEEDLARLSKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALVDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVLSKLVPHLCILFGDSNSQVRDAAILAMVEIYRHVGEKVRVDLYKRGIPPARLEMILAKFDEVQNSGGMILSACKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKTVKPALRDQLHSFWSSKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1472, "header": "tr|A0AAA9S6I3-1|A0AAA9SFG5_BOVIN Computationally mapped isoform of CLIP-associating protein 1 OS=Bos taurus OX=9913 GN=CLASP2 PE=3 SV=1 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7908960, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110430.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110430.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078888.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078888.1" } ] } }, { "isoform_ac": "A0AAA9SAR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#A0AAA9SAR2-1", "sequence": { "sequence": "MAMGDDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDGTASEDGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRSTGALYAPDVYGVSGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1294, "header": "tr|A0AAA9SAR2-1|A0AAA9SFG5_BOVIN Computationally mapped isoform of CLIP-associating protein 1 OS=Bos taurus OX=9913 GN=CLASP2 PE=3 SV=1 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7872528, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090126.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090126.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079255.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079255.1" } ] } }, { "isoform_ac": "A0AAA9SFG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#A0AAA9SFG5-1", "sequence": { "sequence": "MEPRSMEYFSAQVQQKDVGGRLQVGQELLLYLGAPGAIPDLEEDLARLSKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALVDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVLSKLVPHLCILFGDSNSQVRDAAILAMVEIYRHVGEKVRVDLYKRGIPPARLEMILAKFDEVQNSGGMILSACKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKTVKPALRDQLHSFWSSKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1509, "header": "tr|A0AAA9SFG5-1|A0AAA9SFG5_BOVIN Isoform 1 of CLIP-associating protein 1 OS=Bos taurus OX=9913 GN=CLASP2 PE=3 SV=1 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7908960, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095192.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095192.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081200.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081200.1" } ] } }, { "isoform_ac": "A0AAA9SGX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#A0AAA9SGX9-1", "sequence": { "sequence": "MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDGTASEDGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQRSSSPDKNEGSQSANTIGAGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1304, "header": "tr|A0AAA9SGX9-1|A0AAA9SGX9_BOVIN Computationally mapped isoform of Cytoplasmic linker associated protein 2 OS=Bos taurus OX=9913 GN=CLASP2 PE=3 SV=1 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7853587, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115053.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115053.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083156.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083156.1" } ] } }, { "isoform_ac": "A0AAA9SZ66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#A0AAA9SZ66-1", "sequence": { "sequence": "MEPRSMEYFSAQVQQKDVGGRLQVGQELLLYLGAPGAIPDLEEDLARLSKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALVDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVLSKLVPHLCILFGDSNSQVRDAAILAMVEIYRHVGEKVRVDLYKRGIPPARLEMILAKFDEVQNSGGMILSACKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQRSSSPDKNEAGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1452, "header": "tr|A0AAA9SZ66-1|A0AAA9SZ66_BOVIN Computationally mapped isoform of Cytoplasmic linker associated protein 2 OS=Bos taurus OX=9913 GN=CLASP2 PE=4 SV=1 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7908960, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126144.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126144.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090712.1" } ] } }, { "isoform_ac": "A0AAA9TM50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#A0AAA9TM50-1", "sequence": { "sequence": "MEPRSMEYFSAQVQQKDVGGRLQVGQELLLYLGAPGAIPDLEEDLARLSKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALVDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVLSKLVPHLCILFGDSNSQVRDAAILAMVEIYRHVGEKVRVDLYKRGIPPARLEMILAKFDEVQNSGGMILSACKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQRSSSPDKNEAGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1500, "header": "tr|A0AAA9TM50-1|A0AAA9TM50_BOVIN Computationally mapped isoform of CLIP-associating protein 1 OS=Bos taurus OX=9913 GN=CLASP2 PE=3 SV=1 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7908960, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124954.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124954.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099547.1" } ] } }, { "isoform_ac": "E1BQ15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5/entry#E1BQ15-1", "sequence": { "sequence": "MEPRSMEYFSAQVQQKDVGGRLQVGQELLLYLGAPGAIPDLEEDLARLSKTVDALTGWVGSSNYRVSLMGLEILSAFVDRLSTRFKSYVAMVIVALVDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVLSKLVPHLCILFGDSNSQVRDAAILAMVEIYRHVGEKVRVDLYKRGIPPARLEMILAKFDEVQNSGGMILSACKDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPVNSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSAKWSTANPSAVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLGRVRAKLSAPLASMGNAKTDSRGRSRTKMVSQSQRSSSPDKNEAGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASTQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFVNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQGSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPAHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQMKLLNLYIKRAQTGSGGVDPTTDVSGQS", "length": 1461, "header": "tr|E1BQ15-1|E1BQ15_BOVIN Computationally mapped isoform of CLIP-associating protein 1 OS=Bos taurus OX=9913 GN=CLASP2 PE=4 SV=4 CANONICAL=A0AAA9SFG5-1" }, "locus": { "chromosome": "22", "start_pos": 7908960, "end_pos": 7736046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015071.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015071.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015071.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015071.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "basal cortex", "id": "GO:0045180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045180", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "negative regulation of microtubule depolymerization", "id": "GO:0007026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007026", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "establishment of cell polarity", "id": "GO:0030010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "regulation of microtubule polymerization or depolymerization", "id": "GO:0031110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031110", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "negative regulation of cytoskeleton organization", "id": "GO:0051494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "negative regulation of supramolecular fiber organization", "id": "GO:1902904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "mitotic spindle assembly", "id": "GO:0090307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" }, { "name": "establishment of mitotic spindle localization", "id": "GO:0040001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040001", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1029, "end_pos": 1031, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1099, "end_pos": 1101, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1119, "end_pos": 1121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1129, "end_pos": 1131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1165, "end_pos": 1167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1238, "end_pos": 1240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1247, "end_pos": 1249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 840, "end_pos": 842, "annotation": "n_glycosylation_sequon" }, { "start_pos": 864, "end_pos": 866, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFG5" }, { "id": "SM01349", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01349" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TOG", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 232, "start_aa": "Glu", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1029, "end_pos": 1031 }, { "start_pos": 1099, "end_pos": 1101 }, { "start_pos": 1119, "end_pos": 1121 }, { "start_pos": 1129, "end_pos": 1131 }, { "start_pos": 1165, "end_pos": 1167 }, { "start_pos": 1238, "end_pos": 1240 }, { "start_pos": 1247, "end_pos": 1249 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 840, "end_pos": 842 }, { "start_pos": 864, "end_pos": 866 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHA2-1", "uniprot_ac": "A0AAA9SHA2", "uniprot_id": "A0AAA9SHA2_BOVIN", "mass": { "chemical_mass": 56807.0, "monoisotopic_mass": 56807.0 }, "refseq": {}, "gene_names": [ { "name": "FBXL7", "type": "recommended", "evidence": [ { "id": "A0AAA9SHA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ] } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 7", "type": "recommended", "evidence": [ { "id": "A0AAA9SHA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SHA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G3#function" }, { "database": "UniProtKB", "id": "ARBA00058860", "url": "https://www.uniprot.org/uniprotkb/ARBA00058860#function" }, { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2#function" }, { "database": "UniProtKB", "id": "A0AAA9TBV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV1#function" }, { "database": "UniProtKB", "id": "A0AAA9TJD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD7#function" }, { "database": "UniProtKB", "id": "F1N019", "url": "https://www.uniprot.org/uniprotkb/F1N019#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2", "locus": { "chromosome": "20", "start_pos": 57227876, "end_pos": 57707424, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003219", "url": "https://www.ensembl.org/id/ENSBTAG00000003219" } ] } } ], "crossref": [ { "id": "A0AAA9SHA2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22120", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22120", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518806", "url": "https://www.ncbi.nlm.nih.gov/gene/518806", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CDFGAEG", "url": "https://omabrowser.org/oma/group/CDFGAEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N019", "url": "https://www.orthodb.org/?gene=F1N019", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854050", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854050", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N019", "url": "https://www.uniprot.org/uniprotkb/F1N019", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N019-1", "url": "https://www.uniprot.org/uniprotkb/F1N019-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTQAQKNVATSEESDGGDRRPCSLLATRATDLTDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIERLPDHAMVQVFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVSVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLMIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGLEYLAKNCAKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF", "length": 512, "header": "tr|A0AAA9SHA2-1|A0AAA9SHA2_BOVIN Isoform 1 of F-box/LRR-repeat protein 7 OS=Bos taurus OX=9913 GN=FBXL7 PE=3 SV=1 CANONICAL=A0AAA9SHA2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7G3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#A0AAA9S7G3-1", "sequence": { "sequence": "MRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIERLPDHAMVQVFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVSVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLMIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGLEYLAKNCAKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF", "length": 444, "header": "tr|A0AAA9S7G3-1|A0AAA9SHA2_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 7 OS=Bos taurus OX=9913 GN=FBXL7 PE=3 SV=1 CANONICAL=A0AAA9SHA2-1" }, "locus": { "chromosome": "20", "start_pos": 57239378, "end_pos": 57228880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081939.1" } ] } }, { "isoform_ac": "A0AAA9SHA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#A0AAA9SHA2-1", "sequence": { "sequence": "MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTQAQKNVATSEESDGGDRRPCSLLATRATDLTDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIERLPDHAMVQVFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVSVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLMIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGLEYLAKNCAKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF", "length": 512, "header": "tr|A0AAA9SHA2-1|A0AAA9SHA2_BOVIN Isoform 1 of F-box/LRR-repeat protein 7 OS=Bos taurus OX=9913 GN=FBXL7 PE=3 SV=1 CANONICAL=A0AAA9SHA2-1" }, "locus": { "chromosome": "20", "start_pos": 57707225, "end_pos": 57228880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091078.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091078.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084714.1" } ] } }, { "isoform_ac": "A0AAA9TBV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#A0AAA9TBV1-1", "sequence": { "sequence": "MPRSVSARSYDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIERLPDHAMVQVFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVSVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLMIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGLEYLAKNCAKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF", "length": 459, "header": "tr|A0AAA9TBV1-1|A0AAA9TBV1_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 7 OS=Bos taurus OX=9913 GN=FBXL7 PE=3 SV=1 CANONICAL=A0AAA9SHA2-1" }, "locus": { "chromosome": "20", "start_pos": 57481445, "end_pos": 57228880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126846.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126846.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093564.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093564.1" } ] } }, { "isoform_ac": "A0AAA9TJD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#A0AAA9TJD7-1", "sequence": { "sequence": "MATHFSIVAWRIPWLEEPGGLQSLGLQKGKGSSSISSDVSSSTDHTPTQAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIERLPDHAMVQVFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVSVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLMIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGLEYLAKNCAKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF", "length": 507, "header": "tr|A0AAA9TJD7-1|A0AAA9TJD7_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 7 OS=Bos taurus OX=9913 GN=FBXL7 PE=3 SV=1 CANONICAL=A0AAA9SHA2-1" }, "locus": { "chromosome": "20", "start_pos": 57699925, "end_pos": 57228880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096360.1" } ] } }, { "isoform_ac": "F1N019-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2/entry#F1N019-1", "sequence": { "sequence": "MRQIEPASAQEGYSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIERLPDHAMVQVFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVSVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLMIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGLEYLAKNCAKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF", "length": 461, "header": "tr|F1N019-1|A0AAA9SHA2_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 7 OS=Bos taurus OX=9913 GN=FBXL7 PE=3 SV=4 CANONICAL=A0AAA9SHA2-1" }, "locus": { "chromosome": "20", "start_pos": 57239538, "end_pos": 57228880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004177.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004177.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004177.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004177.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8854050", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854050", "resource": "Reactome", "description": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "pmid": "" }, { "name": "G2/M transition of mitotic cell cycle", "id": "GO:0000086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA2" }, { "id": "PS50181", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 178, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGC1-1", "uniprot_ac": "A0AAA9SGC1", "uniprot_id": "A0AAA9SGC1_BOVIN", "mass": { "chemical_mass": 48331.0, "monoisotopic_mass": 48331.0 }, "refseq": {}, "gene_names": [ { "name": "DLK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SGC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ] } ], "protein_names": [ { "name": "Protein delta homolog 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SGC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1/entry#names_and_taxonomy" } ] }, { "name": "Epidermal growth factor-like protein 9", "type": "synonym", "evidence": [ { "id": "A0AAA9SGC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulates adipogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCM7#function" }, { "database": "UniProtKB", "id": "ARBA00060273", "url": "https://www.uniprot.org/uniprotkb/ARBA00060273#function" }, { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1#function" }, { "database": "UniProtKB", "id": "A0AAA9TI61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI61#function" }, { "database": "UniProtKB", "id": "A0AAF6YP12", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP12#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DLK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1", "locus": { "chromosome": "23", "start_pos": 17006839, "end_pos": 17019294, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005850", "url": "https://www.ensembl.org/id/ENSBTAG00000005850" } ] } } ], "crossref": [ { "id": "A0AAA9SGC1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24033", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24033", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24033:SF232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24033:SF232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24044", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24044", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24044:SF423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24044:SF423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24049:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24049:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21700", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21700", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP12", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YP12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YP12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCYFQPHSAAWVLAVEHTMVGFYQMNMMGERGQRVGIDKVLIIMIDRGIKAGCPHVRRSIRLSVPGPALTMPSGCRCLHLVCLLCILGAPVKPARGNDCSSLCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHTGWAGKFCDKDEHICTTQSPCRNGGQCVYDGGGDYHCVCPPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLAGFMGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFTGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPGPAATADSPPGPTLAVLVPATGPIPHSAGAGLLRISVKEVVRRQEAGLGEPSLVAVVVFGAVTAALVLSTVLLTLRAWRRGFCPPGPCCYPAPHYAPARQDQECQVSMLPTGLPLPPDLPPEPGKTTAL", "length": 453, "header": "tr|A0AAA9SGC1-1|A0AAA9SGC1_BOVIN Isoform 1 of Protein delta homolog 2 OS=Bos taurus OX=9913 GN=DLK2 PE=4 SV=2 CANONICAL=A0AAA9SGC1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1/entry#A0AAA9SCM7-1", "sequence": { "sequence": "MGGGLGRAEVGRGVSCSGREGGDARWRITAAHTWPTLYSRLPFSLPCPHVRRSIRLSVPGPALTMPSGCRCLHLVCLLCILGAPVKPARGNDCSSLCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHTGWAGKFCDKDEHICTTQSPCRNGGQCVYDGGGDYHCVCPPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLAGFMGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFTGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPGPAATADSPPGPTLAVLVPATGPIPHSAGAGLLRISVKEVVRRQEAGLGEPSLVAVVVFGAVTAALVLSTVLLTLRAWRRGFCPPGPCCYPAPHYAPARQDQECQVSMLPTGLPLPPDLPPEPGKTTAL", "length": 447, "header": "tr|A0AAA9SCM7-1|A0AAA9SGC1_BOVIN Computationally mapped isoform of Protein delta homolog 2 OS=Bos taurus OX=9913 GN=DLK2 PE=4 SV=1 CANONICAL=A0AAA9SGC1-1" }, "locus": { "chromosome": "23", "start_pos": 17014157, "end_pos": 17009084, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116863.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116863.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083876.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083876.1" } ] } }, { "isoform_ac": "A0AAA9SGC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1/entry#A0AAA9SGC1-1", "sequence": { "sequence": "MCYFQPHSAAWVLAVEHTMVGFYQMNMMGERGQRVGIDKVLIIMIDRGIKAGCPHVRRSIRLSVPGPALTMPSGCRCLHLVCLLCILGAPVKPARGNDCSSLCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHTGWAGKFCDKDEHICTTQSPCRNGGQCVYDGGGDYHCVCPPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLAGFMGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFTGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPGPAATADSPPGPTLAVLVPATGPIPHSAGAGLLRISVKEVVRRQEAGLGEPSLVAVVVFGAVTAALVLSTVLLTLRAWRRGFCPPGPCCYPAPHYAPARQDQECQVSMLPTGLPLPPDLPPEPGKTTAL", "length": 453, "header": "tr|A0AAA9SGC1-1|A0AAA9SGC1_BOVIN Isoform 1 of Protein delta homolog 2 OS=Bos taurus OX=9913 GN=DLK2 PE=4 SV=2 CANONICAL=A0AAA9SGC1-1" }, "locus": { "chromosome": "23", "start_pos": 17018754, "end_pos": 17009084, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125515.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125515.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081534.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081534.2" } ] } }, { "isoform_ac": "A0AAA9TI61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1/entry#A0AAA9TI61-1", "sequence": { "sequence": "MPSGCRCLHLVCLLCILGAPVKPARGNDCSSLCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHTGWAGKFCDKDEHICTTQSPCRNGGQCVYDGGGDYHCVCPPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLAGFMGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFTGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPGPAATADSPPGPTLAVLVPATGPIPHSAGAGLLRISVKEVVRRQEAGLGEPSLVAVVVFGAVTAALVLSTVLLTLRAWRRGFCPPGPCCYPAPHYAPARQDQECQHL", "length": 361, "header": "tr|A0AAA9TI61-1|A0AAA9TI61_BOVIN Computationally mapped isoform of Protein delta homolog 2 OS=Bos taurus OX=9913 GN=DLK2 PE=4 SV=1 CANONICAL=A0AAA9SGC1-1" }, "locus": { "chromosome": "23", "start_pos": 17013086, "end_pos": 17007843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124809.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124809.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095902.1" } ] } }, { "isoform_ac": "A0AAF6YP12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1/entry#A0AAF6YP12-1", "sequence": { "sequence": "MRRTAGAPEGHRCPHVRRSIRLSVPGPALTMPSGCRCLHLVCLLCILGAPVKPARGNDCSSLCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHTGWAGKFCDKDEHICTTQSPCRNGGQCVYDGGGDYHCVCPPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLAGFMGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGFTGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPGPAATADSPPGPTLAVLVPATGPIPHSAGAGLLRISVKEVVRRQEAGLGEPSLVAVVVFGAVTAALVLSTVLLTLRAWRRGFCPPGPCCYPAPHYAPARQDQECQVSMLPTGLPLPPDLPPEPGKTTAL", "length": 413, "header": "tr|A0AAF6YP12-1|A0AAF6YP12_BOVIN Computationally mapped isoform of Protein delta homolog 2 OS=Bos taurus OX=9913 GN=DLK2 PE=4 SV=1 CANONICAL=A0AAA9SGC1-1" }, "locus": { "chromosome": "23", "start_pos": 17019144, "end_pos": 17009084, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007690.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007690.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007690.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007690.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 337, "start_aa": "Thr", "end_pos": 337, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr337", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ], "pmid": "" }, { "name": "regulation of fat cell differentiation", "id": "GO:0045598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045598", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGC1" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 128, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 337 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEL1-1", "uniprot_ac": "A0AAA9SEL1", "uniprot_id": "A0AAA9SEL1_BOVIN", "mass": { "chemical_mass": 157334.0, "monoisotopic_mass": 157334.0 }, "refseq": { "ac": "XP_024852307", "name": "mediator of RNA polymerase II transcription subunit 23 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852307" }, "gene_names": [ { "name": "MED23", "type": "recommended", "evidence": [ { "id": "A0AAA9SEL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ] }, { "name": "MED23", "type": "synonym", "evidence": [ { "id": "XP_024852307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852307" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 23", "type": "recommended", "evidence": [ { "id": "A0AAA9SEL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 23", "type": "synonym", "evidence": [ { "id": "A0AAA9SEL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1/entry#names_and_taxonomy" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 23 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024852307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852307" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1", "locus": { "chromosome": "9", "start_pos": 69540273, "end_pos": 69584038, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012418", "url": "https://www.ensembl.org/id/ENSBTAG00000012418" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012418", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012418", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513610", "url": "https://www.ncbi.nlm.nih.gov/gene/513610", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKW3", "url": "https://www.orthodb.org/?gene=E1BKW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12691", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12691", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12691:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12691:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11573", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11573", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9841922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024852307", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852307", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SE80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKW3", "url": "https://www.uniprot.org/uniprotkb/E1BKW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKW3-1", "url": "https://www.uniprot.org/uniprotkb/E1BKW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSTQVPGSLPVTQ", "length": 1377, "header": "tr|A0AAA9SEL1-1|A0AAA9SEL1_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 23 OS=Bos taurus OX=9913 GN=MED23 PE=3 SV=1 CANONICAL=A0AAA9SEL1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1/entry#A0AAA9SE80-1", "sequence": { "sequence": "MVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSTQVPGSLPVTQ", "length": 1339, "header": "tr|A0AAA9SE80-1|A0AAA9SEL1_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 23 OS=Bos taurus OX=9913 GN=MED23 PE=3 SV=1 CANONICAL=A0AAA9SEL1-1" }, "locus": { "chromosome": "9", "start_pos": 69583730, "end_pos": 69541173, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105739.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105739.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080695.1" } ] } }, { "isoform_ac": "A0AAA9SEL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1/entry#A0AAA9SEL1-1", "sequence": { "sequence": "MVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSTQVPGSLPVTQ", "length": 1377, "header": "tr|A0AAA9SEL1-1|A0AAA9SEL1_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 23 OS=Bos taurus OX=9913 GN=MED23 PE=3 SV=1 CANONICAL=A0AAA9SEL1-1" }, "locus": { "chromosome": "9", "start_pos": 69583730, "end_pos": 69541173, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106990.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106990.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082046.1" } ] } }, { "isoform_ac": "A0AAA9TGD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1/entry#A0AAA9TGD0-1", "sequence": { "sequence": "MVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSTQVDTLTW", "length": 1368, "header": "tr|A0AAA9TGD0-1|A0AAA9TGD0_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 23 OS=Bos taurus OX=9913 GN=MED23 PE=3 SV=1 CANONICAL=A0AAA9SEL1-1" }, "locus": { "chromosome": "9", "start_pos": 69583730, "end_pos": 69540457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125936.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125936.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096096.1" } ] } }, { "isoform_ac": "E1BKW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1/entry#E1BKW3-1", "sequence": { "sequence": "MVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWAGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVSSGSPAPQSTQVPGSLPVTQ", "length": 1371, "header": "tr|E1BKW3-1|E1BKW3_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 23 OS=Bos taurus OX=9913 GN=MED23 PE=3 SV=4 CANONICAL=A0AAA9SEL1-1" }, "locus": { "chromosome": "9", "start_pos": 69583730, "end_pos": 69541173, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046332.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046332.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043641.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043641.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9841922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "resource": "Reactome", "description": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1150, "end_pos": 1152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1150, "end_pos": 1152 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 473, "end_pos": 475 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEB0-1", "uniprot_ac": "A0AAA9SEB0", "uniprot_id": "A0AAA9SEB0_BOVIN", "mass": { "chemical_mass": 88101.0, "monoisotopic_mass": 88101.0 }, "refseq": { "ac": "NP_001192435", "name": "chromosome alignment-maintaining phosphoprotein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192435" }, "gene_names": [ { "name": "CHAMP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SEB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ] }, { "name": "CHAMP1", "type": "synonym", "evidence": [ { "id": "NP_001192435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192435" } ] }, { "name": "ZNF828", "type": "synonym", "evidence": [ { "id": "NP_001192435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192435" } ] } ], "protein_names": [ { "name": "Chromosome alignment-maintaining phosphoprotein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SEB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 828", "type": "synonym", "evidence": [ { "id": "A0AAA9SEB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0/entry#names_and_taxonomy" } ] }, { "name": "chromosome alignment-maintaining phosphoprotein 1", "type": "synonym", "evidence": [ { "id": "NP_001192435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192435" } ] }, { "name": "zinc finger protein 828", "type": "synonym", "evidence": [ { "id": "NP_001192435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192435" } ] } ], "function": [ { "annotation": "Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.", "evidence": [ { "database": "UniProtKB", "id": "F1MFQ9", "url": "https://www.uniprot.org/uniprotkb/F1MFQ9#function" }, { "database": "UniProtKB", "id": "ARBA00054834", "url": "https://www.uniprot.org/uniprotkb/ARBA00054834#function" }, { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0#function" }, { "database": "UniProtKB", "id": "A0AAA9T9D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9D3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHAMP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0", "locus": { "chromosome": "12", "start_pos": 87097988, "end_pos": 87087267, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020861", "url": "https://www.ensembl.org/id/ENSBTAG00000020861" } ] } } ], "crossref": [ { "id": "A0AAA9SEB0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020861", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020861", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100137827", "url": "https://www.ncbi.nlm.nih.gov/gene/100137827", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100137827", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100137827", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKPIPSI", "url": "https://omabrowser.org/oma/group/WKPIPSI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFQ9", "url": "https://www.orthodb.org/?gene=F1MFQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37354", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37354", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37354:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37354:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001192435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192435", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFQ9", "url": "https://www.uniprot.org/uniprotkb/F1MFQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFQ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MFQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVFQELRKTSARLECDHCNFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITAKHSAAEKWNEKPKNQFNKEGEPVKSPPLPEHQKTASSSAELLKPAPALSIETQKLGPVASPESPEPAPLPSLDSQKPGPVVSPEPQTPSLPSPEPPKPAPVSSPELPKPAPLVSESQKLVPVPSPEPQKLAPVSPEPIKATLTNPKPQKHSHFPETLVPPSAPSPESPVLAASPEPWGPSPTASPESRKPAQTVSPEPRKLSPSVSPEPWKLFSAVSSEPRRPAPSVSPGSWKPGPPGSPRSWKSSPSAASGPWKPAKPAPSVSPGPWKPTPSMSSASWKSSSVSSGSWKSPPASPESWKSGPPELRKTATTLSPEHWKTVPPESPELRKPGPTLSPEIRSPAGSPELRKPSGSPEIWKFSPDQRKTSPASVDYPESQKSSRGGSPDLWKSSFFIEPQKPVFPEIRKPGPSGPSESPKAASDIWKPVLSVSTEPRKPSLFSEPTKTAPPASPEPRKRALFPEPRKHALFPELPKSAIFSESQKVVELGDEPQADAIDDQKCDVLVQEELMATPKKLLEDTLFPSSKKLKKDSQENSDAELSSSECIKADLDAVDGKGQESSSDQEQVDVESIDFSKENKMDITSPEQSKNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI", "length": 804, "header": "tr|A0AAA9SEB0-1|A0AAA9SEB0_BOVIN Isoform 1 of Chromosome alignment-maintaining phosphoprotein 1 OS=Bos taurus OX=9913 GN=CHAMP1 PE=4 SV=1 CANONICAL=A0AAA9SEB0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0/entry#A0AAA9SEB0-1", "sequence": { "sequence": "MEVFQELRKTSARLECDHCNFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITAKHSAAEKWNEKPKNQFNKEGEPVKSPPLPEHQKTASSSAELLKPAPALSIETQKLGPVASPESPEPAPLPSLDSQKPGPVVSPEPQTPSLPSPEPPKPAPVSSPELPKPAPLVSESQKLVPVPSPEPQKLAPVSPEPIKATLTNPKPQKHSHFPETLVPPSAPSPESPVLAASPEPWGPSPTASPESRKPAQTVSPEPRKLSPSVSPEPWKLFSAVSSEPRRPAPSVSPGSWKPGPPGSPRSWKSSPSAASGPWKPAKPAPSVSPGPWKPTPSMSSASWKSSSVSSGSWKSPPASPESWKSGPPELRKTATTLSPEHWKTVPPESPELRKPGPTLSPEIRSPAGSPELRKPSGSPEIWKFSPDQRKTSPASVDYPESQKSSRGGSPDLWKSSFFIEPQKPVFPEIRKPGPSGPSESPKAASDIWKPVLSVSTEPRKPSLFSEPTKTAPPASPEPRKRALFPEPRKHALFPELPKSAIFSESQKVVELGDEPQADAIDDQKCDVLVQEELMATPKKLLEDTLFPSSKKLKKDSQENSDAELSSSECIKADLDAVDGKGQESSSDQEQVDVESIDFSKENKMDITSPEQSKNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI", "length": 804, "header": "tr|A0AAA9SEB0-1|A0AAA9SEB0_BOVIN Isoform 1 of Chromosome alignment-maintaining phosphoprotein 1 OS=Bos taurus OX=9913 GN=CHAMP1 PE=4 SV=1 CANONICAL=A0AAA9SEB0-1" }, "locus": { "chromosome": "12", "start_pos": 87096221, "end_pos": 87093810, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134433.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134433.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081926.1" } ] } }, { "isoform_ac": "A0AAA9T9D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0/entry#A0AAA9T9D3-1", "sequence": { "sequence": "MLSFLATSHVVVRRSGLMIVSIDHCQLWWQATALLIFKALVSLVQLLISVLHVLYIVFCGLVKKPCTLACPLKTILKNFSKTTALFLKNIIVYVRKMEVFQELRKTSARLECDHCNFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITAKHSAAEKWNEKPKNQFNKEGEPVKSPPLPEHQKTASSSAELLKPAPALSIETQKLGPVASPESPEPAPLPSLDSQKPGPVVSPEPQTPSLPSPEPPKPAPVSSPELPKPAPLVSESQKLVPVPSPEPQKLAPVSPEPIKATLTNPKPQKHSHFPETLVPPSAPSPESPVLAASPEPWGPSPTASPESRKPAQTVSPEPRKLSPSVSPEPWKLFSAVSSEPRRPAPSVSPGSWKPGPPGSPRSWKSSPSAASGPWKPAKPAPSVSPGPWKPTPSMSSASWKSSSVSSGSWKSPPASPESWKSGPPELRKTATTLSPEHWKTVPPESPELRKPGPTLSPEIRSPAGSPELRKPSGSPEIWKFSPDQRKTSPASVDYPESQKSSRGGSPDLWKSSFFIEPQKPVFPEIRKPGPSGPSESPKAASDIWKPVLSVSTEPRKPSLFSEPTKTAPPASPEPRKRALFPEPRKHALFPELPKSAIFSESQKVVELGDEPQADAIDDQKCDVLVQEELMATPKKLLEDTLFPSSKKLKKDSQENSDAELSSSECIKADLDAVDGKGQESSSDQEQVDVESIDFSKENKMDITSPEQSKNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI", "length": 900, "header": "tr|A0AAA9T9D3-1|A0AAA9T9D3_BOVIN Computationally mapped isoform of Chromosome alignment-maintaining phosphoprotein 1 OS=Bos taurus OX=9913 GN=CHAMP1 PE=4 SV=1 CANONICAL=A0AAA9SEB0-1" }, "locus": { "chromosome": "12", "start_pos": 87096221, "end_pos": 87090297, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120258.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120258.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094607.1" } ] } }, { "isoform_ac": "F1MFQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0/entry#F1MFQ9-1", "sequence": { "sequence": "MHLKMVQLLISVLHVLYIVFCGLVKKPCTLACPLKTILKNFSKTTALFLKNIIVYVRKMEVFQELRKTSARLECDHCNFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITAKHSAAEKWNEKPKNQFNKEGEPVKSPPLPEHQKTASSSAELLKPAPALSIETQKLGPVASPESPEPAPLPSLDSQKPGPVVSPEPQTPSLPSPEPPKPAPVSSPELPKPAPLVSESQKLVPVPSPEPQKLAPVSPEPIKATLTNPKPQKHSHFPETLVPPSAPSPESPVLAASPEPWGPSPTASPESRKPAQTVSPEPRKLSPSVSPEPWKLFSAVSSEPRRPAPSVSPGSWKPGPPGSPRSWKSSPSAASGPWKPAKPAPSVSPGPWKPTPSMSSASWKSSSVSSGSWKSPPASPESWKSGPPELRKTATTLSPEHWKTVPPESPELRKPGPTLSPEIRSPAGSPELRKPSGSPEIWKFSPDQRKTSPASVDYPESQKSSRGGSPDLWKSSFFIEPQKPVFPEIRKPGPSGPSESPKAASDIWKPVLSVSTEPRKPSLFSEPTKTAPPASPEPRKRALFPEPRKHALFPELPKSAIFSESQKVVELGDEPQADAIDDQKCDVLVQEELMATPKKLLEDTLFPSSKKLKKDSQENSDAELSSSECIKADLDAVDGKGQESSSDQEQVDVESIDFSKENKMDITSPEQSKNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI", "length": 862, "header": "tr|F1MFQ9-1|F1MFQ9_BOVIN Computationally mapped isoform of Chromosome alignment-maintaining phosphoprotein 1 OS=Bos taurus OX=9913 GN=CHAMP1 PE=4 SV=3 CANONICAL=A0AAA9SEB0-1" }, "locus": { "chromosome": "12", "start_pos": 87096221, "end_pos": 87089444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027794.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027794.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027794.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027794.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 265, "start_aa": "Thr", "end_pos": 265, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr265", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 354, "start_aa": "Thr", "end_pos": 354, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr354", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100137827", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100137827", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YM97-1", "protein_name": "Chromosome alignment-maintaining phosphoprotein 1", "gene_name": "CHAMP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDMLQILRKTTERLECDHCSFRGTDYENIQIHMGTIHPEYCDEMDAAGLGKLIFYQKSAKLFHCHKCFFTSKMYCNVYYHITAQHAAPEKWNEERKGQVEGGSDSSKKNGAAEPQKCTPPPESLKPALSPEVPKPESKLQKSSVSPESQKSAQTSSSEPERSAQIMSPDSEKSVQAVSPDPEKLVSAVSSDSEKSSPDASPDPQKQSPDASPDPQKPAPAVSPDPQKPAVAVSPEPRRHSPAVSPEPRRHSPAMSPEPRRHSPAVSPEPRRHSPAVSPEPRRYSPGVSPEPKKPTPAVSPEPRRYSPAVSPEPRRHASQMRRPASASSPEIRRPAPAVSPESWRPGPTVSPEPWRSTPHEMQKSSTVSPWAPKASIESRRSAPESRRSGPVASPESRRLVSDSWKSTSFSESQKSTLVSTEPWKPISSVYPEGWKPVLSPDTWKHSSSVSPELRKSSHAVSSDSWKPSFFPEVRKPATSVSPESWKLSESRKSMFFSETQKSTSAASFEVQKRSHFPEPRKRALFPESRKSNPAVSTDVQKRAVFSETQNKVSASLASTEGQKHALCSEAQKSALVSPEVQKHALFSEAQKLAPISPEVQDHTSFLESQKSASPEIQKHGLFNEAHKQAHSASPDTQKQALFPDSQKSAVSPDIQKQAVFSEMQKPAASMSSDIQRHTETTVPSELPKNILFSESHKCVPGFSSEPQTPSESGESDFLSHTLDDQKPLDDLFSPDEQSILAKESPEDMLYSCPKKKPRKENQDNSDSELNSSECGKAEMDSMEMKEQESNSDQEQYDMESSDYSRESKIDAATPTQPQCVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVQSPYKCKICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNDDTPKKHLDSLEPLEEQI", "length": 948 }, "evidence": [ { "id": "A0AAA9SEB0", "url": "https://omabrowser.org/oma/group/A0AAA9SEB0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8K327-1", "protein_name": "Chromosome alignment-maintaining phosphoprotein 1", "gene_name": "Champ1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVCQELRKPALSLECGHCSFRGTDYENVQLHMGSIHPEFCDDMDAGGLGKLIFYQKSAKLFHCHKCFFTSKLYANVYYHITARHAASDKWSEQPKEQPSKDTESGKSPSPPERQNPAFDPAEARPTPALPMEAQKTSPSLCPESQASGPPVLEPQGAGPLISPEPQAPCLPAEASKAAPVPCPERVDPPCELPELEKPERGPSPESVKSALVSSKPPKHSSFADTGAAPSALSPESPVLATSPEPWGPSLSASPESRKPARTASPEPRKPSPAESPELWKPFPAIASEPRRPTPAVSPGSWKPGPPGSPRPWKSSPSATSGPWKSSKPVQPMSPGPWKPIPSVSPGPWKPAPSMSTASWKSSVSSGSWKTPPTSPESWKSGPPELRKTALPLSPEHWKAVPPVSPELRRPGPPLSPEIRSPAGSPELKKPSSSPDLWKVSPDQRKTSPASLDFPEPQKSSCGSPPDLWKSSFIMESQKPNVFSETRKHTASGSSESPKVASDIWKPVLSIDAEPRKSTLFPEPTKAVLPASPEPRKRALFPESRKHVFLPELPKSAVFSDAQKAPELSEEIQLEAVDNAKCDSLAQEGLLATPKKLLDEALSPSSKKLKKDSQENSDAELSSSEYIRADLDTLDTKGQESSSDQEQVDVESIDFSKENKMEMGSTEQAKNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEVNKKLMEALESPLEEQQI", "length": 802 }, "evidence": [ { "id": "A0AAA9SEB0", "url": "https://omabrowser.org/oma/group/A0AAA9SEB0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96JM3-1", "protein_name": "Chromosome alignment-maintaining phosphoprotein 1", "gene_name": "CHAMP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAFQELRKPSARLECDHCSFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITSKHASPDKWNDKPKNQLNKETDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPWKPFPAVSPEPRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKSGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPESQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAASDIWKPVLSIDTEPRKPALFPEPAKTAPPASPEARKRALFPEPRKHALFPELPKSALFSESQKAVELGDELQIDAIDDQKCDILVQEELLASPKKLLEDTLFPSSKKLKKDNQESSDAELSSSEYIKTDLDAMDIKGQESSSDQEQVDVESIDFSKENKMDMTSPEQSRNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI", "length": 812 }, "evidence": [ { "id": "A0AAA9SEB0", "url": "https://omabrowser.org/oma/group/A0AAA9SEB0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "attachment of mitotic spindle microtubules to kinetochore", "id": "GO:0051315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" }, { "name": "protein localization to kinetochore", "id": "GO:0034501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034501", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" }, { "name": "sister chromatid biorientation", "id": "GO:0031134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031134", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" }, { "name": "protein localization to microtubule", "id": "GO:0035372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035372", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEB0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 730, "end_pos": 752, "start_aa": "Tyr", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 265, 354 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEC1-1", "uniprot_ac": "A0AAA9SEC1", "uniprot_id": "A0AAA9SEC1_BOVIN", "mass": { "chemical_mass": 43650.0, "monoisotopic_mass": 43650.0 }, "refseq": {}, "gene_names": [ { "name": "KCTD17", "type": "recommended", "evidence": [ { "id": "A0AAA9SEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ] } ], "protein_names": [ { "name": "Potassium channel tetramerization domain containing 17", "type": "synonym", "evidence": [ { "id": "A0AAA9SEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1", "locus": { "chromosome": "5", "start_pos": 75490595, "end_pos": 75479836, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030646", "url": "https://www.ensembl.org/id/ENSBTAG00000030646" } ] } } ], "crossref": [ { "id": "A0AAA9SEC1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030646", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030646", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18391", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18391", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MWW3", "url": "https://www.orthodb.org/?gene=F1MWW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14958:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14958:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWW3", "url": "https://www.uniprot.org/uniprotkb/F1MWW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWW3-1", "url": "https://www.uniprot.org/uniprotkb/F1MWW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTLGRAMRMEAGEAAPPAGAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELYSSPHGLSSESSRKTKPSHLRIPLTFSPSHHRLLLLRSPPEVLPHLHPPLLPPGSHLHPASSLSAPVRVFSLPAHTSIPGLPWSQSPAPCTQAPRPRIPEHPACRLLHPFWHLLPPGPGGRGAAAPPQRPLPAMSEALLQRFTSSLFLLAGFWLHPLRPEVVLAGRASPGPLACPQSYHAWFIAWRSWREGQKPEGCSSLIS", "length": 392, "header": "tr|A0AAA9SEC1-1|A0AAA9SEC1_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 17 OS=Bos taurus OX=9913 GN=KCTD17 PE=4 SV=1 CANONICAL=A0AAA9SEC1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1/entry#A0AAA9SEC1-1", "sequence": { "sequence": "MQTLGRAMRMEAGEAAPPAGAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELYSSPHGLSSESSRKTKPSHLRIPLTFSPSHHRLLLLRSPPEVLPHLHPPLLPPGSHLHPASSLSAPVRVFSLPAHTSIPGLPWSQSPAPCTQAPRPRIPEHPACRLLHPFWHLLPPGPGGRGAAAPPQRPLPAMSEALLQRFTSSLFLLAGFWLHPLRPEVVLAGRASPGPLACPQSYHAWFIAWRSWREGQKPEGCSSLIS", "length": 392, "header": "tr|A0AAA9SEC1-1|A0AAA9SEC1_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 17 OS=Bos taurus OX=9913 GN=KCTD17 PE=4 SV=1 CANONICAL=A0AAA9SEC1-1" }, "locus": { "chromosome": "5", "start_pos": 75488862, "end_pos": 75479890, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135847.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135847.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081931.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081931.1" } ] } }, { "isoform_ac": "A0AAA9SEE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1/entry#A0AAA9SEE5-1", "sequence": { "sequence": "MRMEAGEAAPPAGAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELYSSPHGLSSESSRKTKSAEEQLEQQQEQEVQVEADTQEKAQSSQDPANLFSLPPPPPPPPLPAGGFWLHPLRPEVVLAGRASPGPLACPQSYHACCYKPEAPGCKAPDRLQGLGVPF", "length": 300, "header": "tr|A0AAA9SEE5-1|A0AAA9SEE5_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 17 OS=Bos taurus OX=9913 GN=KCTD17 PE=4 SV=1 CANONICAL=A0AAA9SEC1-1" }, "locus": { "chromosome": "5", "start_pos": 75489795, "end_pos": 75479911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103474.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103474.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083770.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083770.1" } ] } }, { "isoform_ac": "F1MWW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1/entry#F1MWW3-1", "sequence": { "sequence": "MPGARYLPTSSLLARRMQTLGRAMRMEAGEAAPPAGAGGWGKWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEFYNIGPLIRIIKDRMEEKDYTVTQVPPKHVYRVLQCQEEELTQMVSTMSDGWRFEQLVNIGSSYNYGSEDQAEFLCVVSKELYSSPHGLSSESSRKTKSAEEQLEQQQEQEVQVEADTQEKAQSSQDPANLFSLPPPPPPPPLPAGGPASSSSTSSSSWISPTPCLFPLCPCPGFLSACSHLHPGAALVPVSCALHPGAPAPHPRAPCLPPPAPLLAPPPSRAGGEGSSCTSSAPPAGHV", "length": 364, "header": "tr|F1MWW3-1|F1MWW3_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 17 OS=Bos taurus OX=9913 GN=KCTD17 PE=4 SV=4 CANONICAL=A0AAA9SEC1-1" }, "locus": { "chromosome": "5", "start_pos": 75488660, "end_pos": 75479842, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045619.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045619.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042995.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042995.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "endoplasmic reticulum calcium ion homeostasis", "id": "GO:0032469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032469", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" }, { "name": "positive regulation of cilium assembly", "id": "GO:0045724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC1" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 127, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEC4-1", "uniprot_ac": "A0AAA9SEC4", "uniprot_id": "A0AAA9SEC4_BOVIN", "mass": { "chemical_mass": 7212.0, "monoisotopic_mass": 7212.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SEC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SEC4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEC4", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SEC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRFFFKRKRNNKAKYAKACSSSASGSGSVTSDNYEKNIDSNLQTSTAFEPDFKKKKKRNSKH", "length": 63, "header": "tr|A0AAA9SEC4-1|A0AAA9SEC4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SEC4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC4/entry#A0AAA9SEC4-1", "sequence": { "sequence": "MDRFFFKRKRNNKAKYAKACSSSASGSGSVTSDNYEKNIDSNLQTSTAFEPDFKKKKKRNSKH", "length": 63, "header": "tr|A0AAA9SEC4-1|A0AAA9SEC4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SEC4-1" }, "locus": { "chromosome": "6", "start_pos": 110859242, "end_pos": 110857661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095161.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095161.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082195.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082195.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEG2-1", "uniprot_ac": "A0AAA9SEG2", "uniprot_id": "A0AAA9SEG2_BOVIN", "mass": { "chemical_mass": 7267.0, "monoisotopic_mass": 7267.0 }, "refseq": { "ac": "NP_001403076", "name": "protein TUNAR", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001403076" }, "gene_names": [ { "name": "TUNAR", "type": "recommended", "evidence": [ { "id": "A0AAA9SEG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ] }, { "name": "TUNAR", "type": "synonym", "evidence": [ { "id": "NP_001403076", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001403076" } ] } ], "protein_names": [ { "name": "TCL1 upstream neural differentiation-associated RNA", "type": "synonym", "evidence": [ { "id": "NP_001403076", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001403076" } ] }, { "name": "Transmembrane neural differentiation associated intracellular calcium regulator", "type": "synonym", "evidence": [ { "id": "A0AAA9SEG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2/entry#names_and_taxonomy" } ] }, { "name": "protein TUNAR", "type": "synonym", "evidence": [ { "id": "NP_001403076", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001403076" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUNAR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2", "locus": { "chromosome": "21", "start_pos": 60784153, "end_pos": 60730071, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065187", "url": "https://www.ensembl.org/id/ENSBTAG00000065187" } ] } } ], "crossref": [ { "id": "A0AAA9SEG2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEG2", "database": "AlphaFoldDB", "categories": [] }, { "id": "101905331", "url": "https://www.ncbi.nlm.nih.gov/gene/101905331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR054138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PF21954", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21954", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001403076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001403076", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCSVSLVRKIKTFATKMVITSGNDEDRGGQERESKEESVLAMLGIIGTILNLIVIIFVYIYTTL", "length": 65, "header": "tr|A0AAA9SEG2-1|A0AAA9SEG2_BOVIN Isoform 1 of Transmembrane neural differentiation associated intracellular calcium regulator OS=Bos taurus OX=9913 GN=TUNAR PE=4 SV=1 CANONICAL=A0AAA9SEG2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2/entry#A0AAA9SEG2-1", "sequence": { "sequence": "MRCSVSLVRKIKTFATKMVITSGNDEDRGGQERESKEESVLAMLGIIGTILNLIVIIFVYIYTTL", "length": 65, "header": "tr|A0AAA9SEG2-1|A0AAA9SEG2_BOVIN Isoform 1 of Transmembrane neural differentiation associated intracellular calcium regulator OS=Bos taurus OX=9913 GN=TUNAR PE=4 SV=1 CANONICAL=A0AAA9SEG2-1" }, "locus": { "chromosome": "21", "start_pos": 60781874, "end_pos": 60730776, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089701.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089701.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082236.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082236.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101905331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905331", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of neuron differentiation", "id": "GO:0045665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" }, { "name": "neuron projection morphogenesis", "id": "GO:0048812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" }, { "name": "regulation of cytosolic calcium ion concentration", "id": "GO:0051480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051480", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEK0-1", "uniprot_ac": "A0AAA9SEK0", "uniprot_id": "A0AAA9SEK0_BOVIN", "mass": { "chemical_mass": 21832.0, "monoisotopic_mass": 21832.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Zinc finger protein 740", "type": "recommended", "evidence": [ { "id": "A0AAA9SEK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SEK0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEK0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PHTEIRM", "url": "https://omabrowser.org/oma/group/PHTEIRM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQASLLACEGLAGVSLVPTAASKKMMLSQIASKQAENGERAGSPDVLRCSSQGHRKDSDKSRSRKDDDSLAEASHSKKTVKKVVVVEQNGSFQVKIPKNFVCEHCFGAFRSSYHLKRHILIHTGEKPFECDICDMRFIQKYHLERHKCVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGFQSKTSDGQFSL", "length": 193, "header": "tr|A0AAA9SEK0-1|A0AAA9SEK0_BOVIN Isoform 1 of Zinc finger protein 740 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SEK0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0/entry#A0AAA9SEK0-1", "sequence": { "sequence": "MAQASLLACEGLAGVSLVPTAASKKMMLSQIASKQAENGERAGSPDVLRCSSQGHRKDSDKSRSRKDDDSLAEASHSKKTVKKVVVVEQNGSFQVKIPKNFVCEHCFGAFRSSYHLKRHILIHTGEKPFECDICDMRFIQKYHLERHKCVHSGEKPYQCERCHQCFSRTDRLLRHKRMCQGFQSKTSDGQFSL", "length": 193, "header": "tr|A0AAA9SEK0-1|A0AAA9SEK0_BOVIN Isoform 1 of Zinc finger protein 740 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SEK0-1" }, "locus": { "chromosome": "29", "start_pos": 36225992, "end_pos": 36225214, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097471.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097471.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083823.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083823.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 128, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEK1-1", "uniprot_ac": "A0AAA9SEK1", "uniprot_id": "A0AAA9SEK1_BOVIN", "mass": { "chemical_mass": 35217.0, "monoisotopic_mass": 35217.0 }, "refseq": { "ac": "XP_024831399", "name": "olfactory receptor 10A3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831399" }, "gene_names": [ { "name": "OR10A3I", "type": "recommended", "evidence": [ { "id": "A0AAA9SEK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1" } ] }, { "name": "OR10A3I", "type": "synonym", "evidence": [ { "id": "XP_024831399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831399" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SEK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10A3", "type": "synonym", "evidence": [ { "id": "XP_024831399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831399" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10A3I", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SEK1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782731", "url": "https://www.ncbi.nlm.nih.gov/gene/782731", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782731", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782731", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024831399", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831399", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRQNQSSVVEFILLGFSNFPELQEQLFGAFLVVCLVTLMGNTIIIIVISLEQSLHVPLYLFLQNLSVVDMGMSAVIMPVMLVILSTEKMRISILGCLVQMYFILTLGVTECFLLGVMAFDRFAAICHPLSYPMIMNKMVFMQLVTFSWISGITVATVQTTWVFSFPFCGSNEINHISCETPAVLELACADTFLFEIYAFTGTLLTVIVPFSLILLSYIRILFAILKMPSTTGKQKAFSTCASHLTSVTLFYGTASMTYLQPKSGYSPETKKLTSLAYSLLTPLLNPLIYSLRNSEMKRALMKIWQRKVALHTF", "length": 314, "header": "tr|A0AAA9SEK1-1|A0AAA9SEK1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10A3I PE=3 SV=1 CANONICAL=A0AAA9SEK1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1/entry#A0AAA9SEK1-1", "sequence": { "sequence": "MKRQNQSSVVEFILLGFSNFPELQEQLFGAFLVVCLVTLMGNTIIIIVISLEQSLHVPLYLFLQNLSVVDMGMSAVIMPVMLVILSTEKMRISILGCLVQMYFILTLGVTECFLLGVMAFDRFAAICHPLSYPMIMNKMVFMQLVTFSWISGITVATVQTTWVFSFPFCGSNEINHISCETPAVLELACADTFLFEIYAFTGTLLTVIVPFSLILLSYIRILFAILKMPSTTGKQKAFSTCASHLTSVTLFYGTASMTYLQPKSGYSPETKKLTSLAYSLLTPLLNPLIYSLRNSEMKRALMKIWQRKVALHTF", "length": 314, "header": "tr|A0AAA9SEK1-1|A0AAA9SEK1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10A3I PE=3 SV=1 CANONICAL=A0AAA9SEK1-1" }, "locus": { "chromosome": "15", "start_pos": 44607537, "end_pos": 44606596, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093657.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093657.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082274.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082274.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782731", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782731", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEL7-1", "uniprot_ac": "A0AAA9SEL7", "uniprot_id": "A0AAA9SEL7_BOVIN", "mass": { "chemical_mass": 241579.0, "monoisotopic_mass": 241579.0 }, "refseq": {}, "gene_names": [ { "name": "ASXL3", "type": "recommended", "evidence": [ { "id": "A0AAA9SEL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ] } ], "protein_names": [ { "name": "ASXL transcriptional regulator 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SEL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASXL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7", "locus": { "chromosome": "24", "start_pos": 23448759, "end_pos": 23641255, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047003", "url": "https://www.ensembl.org/id/ENSBTAG00000047003" } ] } } ], "crossref": [ { "id": "ENSBTAG00000047003", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047003", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538107", "url": "https://www.ncbi.nlm.nih.gov/gene/538107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026905", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026905", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538107", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "G3N2D1", "url": "https://www.orthodb.org/?gene=G3N2D1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13578", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13578", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13578:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13578:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13919", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13919", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13922", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13922", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2D1", "url": "https://www.uniprot.org/uniprotkb/G3N2D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2D1-1", "url": "https://www.uniprot.org/uniprotkb/G3N2D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETRNGTSPLACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCSADGTLDLGCESELDGSEMAEANANGEGNGVCAKQVTDEASSTRDASLPNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGEKLGMSREDSVKLTSGPNTDGAESSSSCGTPGLPSLSAQTPLKEQQPKSLKSPTSPEPEFCATLCPMVDVGKDVMTESESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEESESPVTSHEEPQLAPPEDHVESCVMMNDVLETLPPIEVNVEEKSESPQEEMSVVIDQLEVCDSLIPSTLSVTHVSDTEHKEPETALETNTPEIKTGSSSLEGRFPSEGIAVDMELQSEPDEQLSENACVSETSFSSESPEGACASLTSPGGENQCTSEEPCTPTSLETTFCSEVSSTENVDKYNQRNAADENLHASLLSEISPISTSPETSEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTPETTFISSLPLPSETSPVSSSSMNERMVHQQRKSTSVSEEPPSPQKDEGSALAKPLGEGVTSPQKILSDAPEPIKMASSSIAPEAYSSEELHSNTLNQQPCKSHVETEKSYPTSIPELPSTEMIKVKNHNVLQRAEKKGMSSPLDLPVFSEEIESKGNEVPSGKLQDKQYVSSVDKASFSEGSRNKMHKQGSSQNRLENSHSSKLSEPSKSPDGVRNESRESEISKRKTAEHHSFGICKEKRARIDDDQSSAGRNISSSSPPEKEPPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPEARASSSTSVSSGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKARTLAHIKEQTKAKLFAKHQARAHLFQNPKEPRGPPQLGPKEGPPSLDVVSPAPETKIEGSPGVIIVNPNCRSPSNKAAHLRDTTTVLQQPLNPTKLAETATDLSVHSSDENTPVSHLPEKMVSSTSSENSSVPMLFNKNPVPASVCSTALSGAIKEHPFVSPVDKSSVLMSVDSANATISACNISMLKTIQGTDTPCIAIIPKCMESTPLPAPSEGSGSASPHNDQLALVPSSSAGSLVSAQYTSVPAPSIGSNLPNHLSSSSVLMPPTGMNNRYPSEKIAMPGSEEPATVPMGTTVRAALGCRDPVAVTDALVARPPVAVFSGSMLTISSYDSPPKLSAESLDKTSGTRNRGDPSGKPQPTPGGFTPAAVNRSIPCKVIVDHSTTLTSTLSLTVSLESTEAGLELQTRAGRTEAAGPPMACPQVSVISRPEPVALEGGDHSSSFITASVAEQDSQTMKATCPGLREGLLVIPDKLKEGTPPSHSFAEQARGSATFKSEADTTCSHPYNPGSRICWSEDGMRSTGQPPPSHPASSKQKDYLEQSCPKSIKTEHASYSHVVELQPRNLITSVTLPVKSEPHDVDKGFRMDTEDFPGSELPAPAAEAAPSVQPPQTVKAPASGPLEEAVSLATDNLKRVPSAGNSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLPTTSAGKAAPERNVVEMPLSSPNPDGKGYLAGALAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLADPDVKGVPCVLGSGLSPLAHSQPLKQEWLNKHPAQSRIAHSPEVKQQKRLLPSCSFQQTLFHVDKNGGFHPDPGTSHRQQFYQMPLTPRGPLPPAALLPASAKTSAGCSSFAFNRHLEQKGLGEVGLSPAPHQLRLANMAPPNVPIKEGDDVGGTPHGMPHKALVHLPPPPPPPPLALPPPPPPPPPPPPPPLPPSHPNPEVPPEQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKNADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFGSTSFRRATSAIEKSIGVLGSGSSPTTGLPAQNAQMPVQNFADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR", "length": 2257, "header": "tr|A0AAA9SEL7-1|A0AAA9SEL7_BOVIN Isoform 1 of ASXL transcriptional regulator 3 OS=Bos taurus OX=9913 GN=ASXL3 PE=3 SV=1 CANONICAL=A0AAA9SEL7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7/entry#A0AAA9SEL7-1", "sequence": { "sequence": "MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETRNGTSPLACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCSADGTLDLGCESELDGSEMAEANANGEGNGVCAKQVTDEASSTRDASLPNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGEKLGMSREDSVKLTSGPNTDGAESSSSCGTPGLPSLSAQTPLKEQQPKSLKSPTSPEPEFCATLCPMVDVGKDVMTESESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEESESPVTSHEEPQLAPPEDHVESCVMMNDVLETLPPIEVNVEEKSESPQEEMSVVIDQLEVCDSLIPSTLSVTHVSDTEHKEPETALETNTPEIKTGSSSLEGRFPSEGIAVDMELQSEPDEQLSENACVSETSFSSESPEGACASLTSPGGENQCTSEEPCTPTSLETTFCSEVSSTENVDKYNQRNAADENLHASLLSEISPISTSPETSEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTPETTFISSLPLPSETSPVSSSSMNERMVHQQRKSTSVSEEPPSPQKDEGSALAKPLGEGVTSPQKILSDAPEPIKMASSSIAPEAYSSEELHSNTLNQQPCKSHVETEKSYPTSIPELPSTEMIKVKNHNVLQRAEKKGMSSPLDLPVFSEEIESKGNEVPSGKLQDKQYVSSVDKASFSEGSRNKMHKQGSSQNRLENSHSSKLSEPSKSPDGVRNESRESEISKRKTAEHHSFGICKEKRARIDDDQSSAGRNISSSSPPEKEPPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPEARASSSTSVSSGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKARTLAHIKEQTKAKLFAKHQARAHLFQNPKEPRGPPQLGPKEGPPSLDVVSPAPETKIEGSPGVIIVNPNCRSPSNKAAHLRDTTTVLQQPLNPTKLAETATDLSVHSSDENTPVSHLPEKMVSSTSSENSSVPMLFNKNPVPASVCSTALSGAIKEHPFVSPVDKSSVLMSVDSANATISACNISMLKTIQGTDTPCIAIIPKCMESTPLPAPSEGSGSASPHNDQLALVPSSSAGSLVSAQYTSVPAPSIGSNLPNHLSSSSVLMPPTGMNNRYPSEKIAMPGSEEPATVPMGTTVRAALGCRDPVAVTDALVARPPVAVFSGSMLTISSYDSPPKLSAESLDKTSGTRNRGDPSGKPQPTPGGFTPAAVNRSIPCKVIVDHSTTLTSTLSLTVSLESTEAGLELQTRAGRTEAAGPPMACPQVSVISRPEPVALEGGDHSSSFITASVAEQDSQTMKATCPGLREGLLVIPDKLKEGTPPSHSFAEQARGSATFKSEADTTCSHPYNPGSRICWSEDGMRSTGQPPPSHPASSKQKDYLEQSCPKSIKTEHASYSHVVELQPRNLITSVTLPVKSEPHDVDKGFRMDTEDFPGSELPAPAAEAAPSVQPPQTVKAPASGPLEEAVSLATDNLKRVPSAGNSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLPTTSAGKAAPERNVVEMPLSSPNPDGKGYLAGALAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLADPDVKGVPCVLGSGLSPLAHSQPLKQEWLNKHPAQSRIAHSPEVKQQKRLLPSCSFQQTLFHVDKNGGFHPDPGTSHRQQFYQMPLTPRGPLPPAALLPASAKTSAGCSSFAFNRHLEQKGLGEVGLSPAPHQLRLANMAPPNVPIKEGDDVGGTPHGMPHKALVHLPPPPPPPPLALPPPPPPPPPPPPPPLPPSHPNPEVPPEQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKNADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFGSTSFRRATSAIEKSIGVLGSGSSPTTGLPAQNAQMPVQNFADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR", "length": 2257, "header": "tr|A0AAA9SEL7-1|A0AAA9SEL7_BOVIN Isoform 1 of ASXL transcriptional regulator 3 OS=Bos taurus OX=9913 GN=ASXL3 PE=3 SV=1 CANONICAL=A0AAA9SEL7-1" }, "locus": { "chromosome": "24", "start_pos": 23641099, "end_pos": 23449249, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095967.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095967.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082290.1" } ] } }, { "isoform_ac": "A0AAA9T9G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7/entry#A0AAA9T9G0-1", "sequence": { "sequence": "MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSGTSPLACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCSADGTLDLGCESELDGSEMAEANANGEGNGVCAKQVTDEASSTRDASLPNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGEKLGMSREDSVKLTSGPNTDGAESSSSCGTPGLPSLSAQTPLKEQQPKSLKSPTSPEPEFCATLCPMVDVGKDVMTESESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEESESPVTSHEEPQLAPPEDHVESCVMMNDVLETLPPIEVNVEEKSESPQEEMSVVIDQLEVCDSLIPSTLSVTHVSDTEHKEPETALETNTPEIKTGSSSLEGRFPSEGIAVDMELQSEPDEQLSENACVSETSFSSESPEGACASLTSPGGENQCTSEEPCTPTSLETTFCSEVSSTENVDKYNQRNAADENLHASLLSEISPISTSPETSEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTPETTFISSLPLPSETSPVSSSSMNERMVHQQRKSTSVSEEPPSPQKDEGSALAKPLGEGVTSPQKILSDAPEPIKMASSSIAPEAYSSEELHSNTLNQQPCKSHVETEKSYPTSIPELPSTEMIKVKNHNVLQRAEKKGMSSPLDLPVFSEEIESKGNEVPSGKLQDKQYVSSVDKASFSEGSRNKMHKQGSSQNRLENSHSSKLSEPSKSPDGVRNESRESEISKRKTAEHHSFGICKEKRARIDDDQSSAGRNISSSSPPEKEPPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPEARASSSTSVSSGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKARTLAHIKEQTKAKLFAKHQARAHLFQNPKEPRGPPQLGPKEGPPSLDVVSPAPETKIEGSPGVIIVNPNCRSPSNKAAHLRDTTTVLQQPLNPTKLAETATDLSVHSSDENTPVSHLPEKMVSSTSSENSSVPMLFNKNPVPASVCSTALSGAIKEHPFVSPVDKSSVLMSVDSANATISACNISMLKTIQGTDTPCIAIIPKCMESTPLPAPSEGSGSASPHNDQLALVPSSSAGSLVSAQYTSVPAPSIGSNLPNHLSSSSVLMPPTGMNNRYPSEKIAMPGSEEPATVPMGTTVRAALGCRDPVAVTDALVARPPVAVFSGSMLTISSYDSPPKLSAESLDKTSGTRNRGDPSGKPQPTPGGFTPAAVNRSIPCKVIVDHSTTLTSTLSLTVSLESTEAGLELQTRAGRTEAAGPPMACPQVSVISRPEPVALEGGDHSSSFITASVAEQDSQTMKATCPGLREGLLVIPDKLKEGTPPSHSFAEQARGSATFKSEADTTCSHPYNPGSRICWSEDGMRSTGQPPPSHPASSKQKDYLEQSCPKSIKTEHASYSHVVELQPRNLITSVTLPVKSEPHDVDKGFRMDTEDFPGSELPAPAAEAAPSVQPPQTVKAPASGPLEEAVSLATDNLKRVPSAGNSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLPTTSAGKAAPERNVVEMPLSSPNPDGKGYLAGALAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLADPDVKGVPCVLGSGLSPLAHSQPLKQEWLNKHPAQSRIAHSPEVKQQKRLLPSCSFQQTLFHVDKNGGFHPDPGTSHRQQFYQMPLTPRGPLPPAALLPASAKTSAGCSSFAFNRHLEQKGLGEVGLSPAPHQLRLANMAPPNVPIKEGDDVGGTPHGMPHKALVHLPPPPPPPPLALPPPPPPPPPPPPPPLPPSHPNPEVPPEQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKNADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFGSTSFRRATSAIEKSIGVLGSGSSPTTGLPAQNAQMPVQNFADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR", "length": 2216, "header": "tr|A0AAA9T9G0-1|A0AAA9T9G0_BOVIN Computationally mapped isoform of ASXL transcriptional regulator 3 OS=Bos taurus OX=9913 GN=ASXL3 PE=3 SV=1 CANONICAL=A0AAA9SEL7-1" }, "locus": { "chromosome": "24", "start_pos": 23641099, "end_pos": 23449249, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099961.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099961.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094632.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094632.1" } ] } }, { "isoform_ac": "G3N2D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7/entry#G3N2D1-1", "sequence": { "sequence": "MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSGTSPLACLNAMLHTNTRIGDGTFFKIPGKSGLYALKKEESSCSADGTLDLGCESELDGSEMAEANANGEGNGVCAKQVTDEASSTRDASLPNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASLPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGEKLGMSREDSVKLTSGPNTDGAESSSSCGTPGLPSLSAQTPLKEQQPKSLKSPTSPEPEFCATLCPMVDVGKDVMTESESEDILIPEESVIQEEIAEEVETSICECQDENHKTIPEFSEESESPVTSHEEPQLAPPEDHVESCVMMNDVLETLPPIEVNVEEKSESPQEEMSVVIDQLEVCDSLIPSTLSVTHVSDTEHKEPETALETNTPEIKTGSSSLEGRFPSEGIAVDMELQSEPDEQLSENACVSETSFSSESPEGACASLTSPGGENQCTSEEPCTPTSLETTFCSEVSSTENVDKYNQRNAADENLHASLLSEISPISTSPETSEASLMSNLPLTSEASPVSNLPLTSETSPMSDLPLTSETSSVSSMLLTPETTFISSLPLPSETSPVSSSSMNERMVHQQRKSTSVSEEPPSPQKDEGSALAKPLGEGVTSPQKILSDAPEPIKMASSSIAPEAYSSEELHSNTLNQQPCKSHVETEKSYPTSIPELPSTEMIKVKNHNVLQRAEKKGMSSPLDLPVFSEEIESKGNEVPSGKLQDKQYVSSVDKASFSEGSRNKMHKQGSSQNRLENSHSSKLSEPSKSPDGVRNESRESEISKRKTAEHHSFGICKEKRARIDDDQSSAGRNISSSSPPEKEPPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKPEARASSSTSVSSGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKARTLAHIKEQTKAKLFAKHQARAHLFQNPKEPRGPPQLGPKEGPPSLDVVSPAPETKIEGSPGVIIVNPNCRSPSNKAAHLRDTTTVLQQPLNPTKLAETATDLSVHSSDENTPVSHLPEKMVSSTSSENSSVPMLFNKNPVPASVCSTALSGAIKEHPFVSPVDKSSVLMSVDSANATISACNISMLKTIQGTDTPCIAIIPKCMESTPLPAPSEGSGSASPHNDQLALVPSSSAGSLVSAQYTSVPAPSIGSNLPNHLSSSSVLMPPTGMNNRYPSEKIAMPGSEEPATVPMGTTVRAALGCRDPVAVTDALVARPPVAVFSGSMLTISSYDSPPKLSAESLDKTSGTRNRGDPSGKPQPTPGGFTPAAVNRSIPCKVIVDHSTTLTSTLSLTVSLESTEAGLELQTRAGRTEAAGPPMACPQVSVISRPEPVALEGGDHSSSFITASVAEQDSQTMKATCPGLREGLLVIPDKLKEGTPPSHSFAEQARGSATFKSEADTTCSHPYNPGSRICWSEDGMRSTGQPPPSHPASSKQKDYLEQSCPKSIKTEHASYSHVVELQPRNLITSVTLPVKSEPHDVDKGFRMDTEDFPGSELPAPAAEAAPSVQPPQTVKAPASGPLEEAVSLATDNLKRVPSAGNSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLPTTSAGKAAPERNVVEMPLSSPNPDGKGYLAGALAPLQMRKRENHPKKRVARTVGEHTQVKCEPGKLLADPDVKGVPCVLGSGLSPLAHSQPLKQEWLNKHPAQSRIAHSPEVKQQKRLLPSCSFQQTLFHVDKNGGFHPDPGTSHRQQFYQMPLTPRGPLPPAALLPASAKTSAGCSSFAFNRHLEQKGLGEVGLSPAPHQLRLANMAPPNVPIKEGDDVGGTPHGMPHKALVHLPPPPPPPPLALPPPPPPPPPPPPPPLPPSHPNPEVPPEQKQPPVTMETTKRLSWPQSTGICSNIKSEPLSFEEGLSSSCELGMKQVSYDQNEMKEQLKAFALKNADFSSYLLSEPQKPFTQLAAQKMQVQQQQQLCGNYPTIHFGSTSFRRATSAIEKSIGVLGSGSSPTTGLPAQNAQMPVQNFADSSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR", "length": 2256, "header": "tr|G3N2D1-1|G3N2D1_BOVIN Computationally mapped isoform of ASXL transcriptional regulator 3 OS=Bos taurus OX=9913 GN=ASXL3 PE=3 SV=3 CANONICAL=A0AAA9SEL7-1" }, "locus": { "chromosome": "24", "start_pos": 23641099, "end_pos": 23449249, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064050.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064050.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056043.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056043.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1461, "start_aa": "Thr", "end_pos": 1461, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1461", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 390, "start_aa": "Thr", "end_pos": 390, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr390", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538107", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538107", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "peroxisome proliferator activated receptor binding", "id": "GO:0042975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "PR-DUB complex", "id": "GO:0035517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "negative regulation of lipid biosynthetic process", "id": "GO:0051055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" }, { "name": "animal organ morphogenesis", "id": "GO:0009887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1228, "end_pos": 1230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1275, "end_pos": 1277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1282, "end_pos": 1284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1471, "end_pos": 1473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1741, "end_pos": 1743, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 955, "end_pos": 957, "annotation": "n_glycosylation_sequon" }, { "start_pos": 993, "end_pos": 995, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" }, { "id": "PS51916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEUBAD", "eco_id": "ECO_0000259", "start_pos": 255, "end_pos": 364, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SEL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEL7" }, { "id": "PS51913", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51913" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HTH HARE-type", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 85, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 390, 1461 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1228, "end_pos": 1230 }, { "start_pos": 1275, "end_pos": 1277 }, { "start_pos": 1282, "end_pos": 1284 }, { "start_pos": 1471, "end_pos": 1473 }, { "start_pos": 1741, "end_pos": 1743 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 955, "end_pos": 957 }, { "start_pos": 993, "end_pos": 995 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEM2-1", "uniprot_ac": "A0AAA9SEM2", "uniprot_id": "A0AAA9SEM2_BOVIN", "mass": { "chemical_mass": 223513.0, "monoisotopic_mass": 223513.0 }, "refseq": {}, "gene_names": [ { "name": "MYH13", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ] } ], "protein_names": [ { "name": "Myosin heavy chain 13", "type": "synonym", "evidence": [ { "id": "A0AAA9SEM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYH13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2", "locus": { "chromosome": "19", "start_pos": 29329125, "end_pos": 29377097, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025337", "url": "https://www.ensembl.org/id/ENSBTAG00000025337" } ] } } ], "crossref": [ { "id": "ENSBTAG00000025337", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025337", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14923", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14923", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042702", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042702", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45615", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45615", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45615:SF64", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45615:SF64", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01576", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01576", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02736", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02736", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZX6", "url": "https://www.uniprot.org/uniprotkb/F1MZX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZX6-1", "url": "https://www.uniprot.org/uniprotkb/F1MZX6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSDAEMAIFGEAAPYLRKSEKERIEAQNRPFDSKKACFAVDDKELYVKGMIQGRENDKVTVKTLDDRTLTLNSEQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSGASKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHHLVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTRTQALCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEIATMKEDFERAKEELARSEARRKELEEKMVSLLQEKNDLQLQVQTETENLMDAEERCEGLIKSKIQLEAKVKELNERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTREKKSLQETHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGCLEQEKKLRADLERAKRKLEGDLKLCQESIMDLENDKQQMEEKLQKKDFEISQLQTKIEDKQVHSLQLQKKIKELQARTEELEEEVEAEHTLRGKIEKQRADLSRELEEISERLEEASGATSVQIEMNKKREAEFQKLRRDLEEATLQHEATTTTLRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIETVSKSKSNVERMCRTVEDQFNEIKAKDDQQTQLIHDLNMQKARLQTQNGELSHQVEEKAALISQLTKGKQVLTQQLEDLKRQLEEETKAKSALAHALKSARHDCDLLREQYEEEQEGKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTEAASSKCASLEKTKQRLQGEVDDLMLDLERANTACACLDKKQRNFDKVISEWKQKLDESQAELEAAQKESRSHSTEVFKMRNAYEEVVDQLETLRRENKNLQEEISDLTMQIAETNKNLQEVEKTKKQAEQEKSDLQAALEEVEGSLEHEESKILRVQLELNQVKSELDRRLTEKDEEIEQLKRSSQRAAEAMQSILDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRSVQGQLKDSQLHLDDALRSNEDLKEQLAMVERRNGLLQEELEEMKVALEQTERTRKLSEQELLDASDRMQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESKNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIHKLENRVRELESELDAEQKRGAEALKGAHRYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKAYKRQAEEAEEQANTQLSRCRRVQHELQEAEERADIAESQVNKLRAKSRDVGAQKMEE", "length": 1938, "header": "tr|A0AAA9SEM2-1|A0AAA9SEM2_BOVIN Isoform 1 of Myosin heavy chain 13 OS=Bos taurus OX=9913 GN=MYH13 PE=3 SV=1 CANONICAL=A0AAA9SEM2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2/entry#A0AAA9SEM2-1", "sequence": { "sequence": "MSSDAEMAIFGEAAPYLRKSEKERIEAQNRPFDSKKACFAVDDKELYVKGMIQGRENDKVTVKTLDDRTLTLNSEQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSGASKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHHLVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTRTQALCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEIATMKEDFERAKEELARSEARRKELEEKMVSLLQEKNDLQLQVQTETENLMDAEERCEGLIKSKIQLEAKVKELNERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTREKKSLQETHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGCLEQEKKLRADLERAKRKLEGDLKLCQESIMDLENDKQQMEEKLQKKDFEISQLQTKIEDKQVHSLQLQKKIKELQARTEELEEEVEAEHTLRGKIEKQRADLSRELEEISERLEEASGATSVQIEMNKKREAEFQKLRRDLEEATLQHEATTTTLRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIETVSKSKSNVERMCRTVEDQFNEIKAKDDQQTQLIHDLNMQKARLQTQNGELSHQVEEKAALISQLTKGKQVLTQQLEDLKRQLEEETKAKSALAHALKSARHDCDLLREQYEEEQEGKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTEAASSKCASLEKTKQRLQGEVDDLMLDLERANTACACLDKKQRNFDKVISEWKQKLDESQAELEAAQKESRSHSTEVFKMRNAYEEVVDQLETLRRENKNLQEEISDLTMQIAETNKNLQEVEKTKKQAEQEKSDLQAALEEVEGSLEHEESKILRVQLELNQVKSELDRRLTEKDEEIEQLKRSSQRAAEAMQSILDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRSVQGQLKDSQLHLDDALRSNEDLKEQLAMVERRNGLLQEELEEMKVALEQTERTRKLSEQELLDASDRMQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESKNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIHKLENRVRELESELDAEQKRGAEALKGAHRYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKAYKRQAEEAEEQANTQLSRCRRVQHELQEAEERADIAESQVNKLRAKSRDVGAQKMEE", "length": 1938, "header": "tr|A0AAA9SEM2-1|A0AAA9SEM2_BOVIN Isoform 1 of Myosin heavy chain 13 OS=Bos taurus OX=9913 GN=MYH13 PE=3 SV=1 CANONICAL=A0AAA9SEM2-1" }, "locus": { "chromosome": "19", "start_pos": 29377097, "end_pos": 29329214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134012.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134012.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080850.1" } ] } }, { "isoform_ac": "F1MZX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2/entry#F1MZX6-1", "sequence": { "sequence": "MSSDAEMAIFGEAAPYLRKSEKERIEAQNRPFDSKKACFAVDDKELYVKGMIQGRENDKVTVKTLDDRTLTLNSEQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGDSGASKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHHLVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTRTQALCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEIATMKEDFERAKEELARSEARRKELEEKMVSLLQEKNDLQLQVQTETENLMDAEERCEGLIKSKIQLEAKVKELNERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTREKKSLQETHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGCLEQEKKLRADLERAKRKLEGDLKLCQESIMDLENDKQQMEEKLQKKDFEISQLQTKIEDKQVHSLQLQKKIKELQARTEELEEEVEAEHTLRGKIEKQRADLSRELEEISERLEEASGATSVQIEMNKKREAEFQKLRRDLEEATLQHEATTTTLRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIETVSKSKSNVERMCRTVEDQFNEIKAKDDQQTQLIHDLNMQKARLQTQNGELSHQVEEKAALISQLTKGKQVLTQQLEDLKRQLEEETKAKSALAHALKSARHDCDLLREQYEEEQEGKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTEAASSKCASLEKTKQRLQGEVDDLMLDLERANTACACLDKKQRNFDKVISEWKQKLDESQAELEAAQKESRSHSTEVFKMRNAYEEVVDQLETLRRENKNLQEEISDLTMQIAETNKNLQEVEKTKKQAEQEKSDLQAALEEVEGSLEHEESKILRVQLELNQVKSELDRRLTEKDEEIEQLKRSSQRAAEAMQSILDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRSVQGQLKDSQLHLDDALRSNEDLKEQLAMVERRNGLLQEELEEMKVALEQTERTRKLSEQELLDASDRMQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESKNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIHKLENRVRELESELDAEQKRGAEALKGAHRYERKVKEMTYQVEEDRKNILRLQDLVDKLQAKVKAYKRQAEEAEEQANTQLSRCRRVQHELQEAEERADIAESQVNKLRAKSRDVPGGSSSQEQ", "length": 1936, "header": "tr|F1MZX6-1|F1MZX6_BOVIN Computationally mapped isoform of Myosin heavy chain 13 OS=Bos taurus OX=9913 GN=MYH13 PE=3 SV=4 CANONICAL=A0AAA9SEM2-1" }, "locus": { "chromosome": "19", "start_pos": 29377097, "end_pos": 29329505, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035550.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035550.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035421.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035421.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "myosin filament", "id": "GO:0032982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "myofibril", "id": "GO:0030016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030016", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" }, { "name": "myosin II complex", "id": "GO:0016460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016460", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "muscle contraction", "id": "GO:0006936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1724, "end_pos": 1726, "annotation": "n_glycosylation_sequon" }, { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 680, "end_pos": 682, "annotation": "n_glycosylation_sequon" }, { "start_pos": 730, "end_pos": 732, "annotation": "n_glycosylation_sequon" }, { "start_pos": 744, "end_pos": 746, "annotation": "n_glycosylation_sequon" }, { "start_pos": 981, "end_pos": 983, "annotation": "n_glycosylation_sequon" }, { "start_pos": 992, "end_pos": 994, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" }, { "id": "PS51844", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51844" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin N-terminal SH3-like", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 82, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SEM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM2" }, { "id": "PS51456", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51456" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin motor", "eco_id": "ECO_0000259", "start_pos": 86, "end_pos": 782, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1724, "end_pos": 1726 }, { "start_pos": 172, "end_pos": 174 }, { "start_pos": 242, "end_pos": 244 }, { "start_pos": 481, "end_pos": 483 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 680, "end_pos": 682 }, { "start_pos": 730, "end_pos": 732 }, { "start_pos": 744, "end_pos": 746 }, { "start_pos": 981, "end_pos": 983 }, { "start_pos": 992, "end_pos": 994 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEM5-1", "uniprot_ac": "A0AAA9SEM5", "uniprot_id": "A0AAA9SEM5_BOVIN", "mass": { "chemical_mass": 53005.0, "monoisotopic_mass": 53005.0 }, "refseq": {}, "gene_names": [ { "name": "MRPL40", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL40", "type": "recommended", "evidence": [ { "id": "A0AAA9SEM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L40, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAA9SEM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5", "locus": { "chromosome": "17", "start_pos": 72696756, "end_pos": 72692231, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019891", "url": "https://www.ensembl.org/id/ENSBTAG00000019891" } ] } } ], "crossref": [ { "id": "A0AAA9SEM5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019891", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019891", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101907103", "url": "https://www.ncbi.nlm.nih.gov/gene/101907103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1R3", "url": "https://www.orthodb.org/?gene=F1N1R3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13359:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13359:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09812", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09812", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SEM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R3", "url": "https://www.uniprot.org/uniprotkb/F1N1R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1R3-1", "url": "https://www.uniprot.org/uniprotkb/F1N1R3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPPPPPALRPPPAPRPQRRRAIAGPRPPPPPPQPPPALGRRRRRHSRIPRAAPPPAAPGQRRKSRRAPAKRPRRETAPRVLGPRGSRAGRPAGRAGGRRRVGSAPGGGGEGGPAGGARAGGRAGLGGAGGGRCPGGARRANWRAHAAPGALSLGTRAREPRAAQRPGPDAGGRAAAFTACPARLAREGFRAPGRRRPRRARHGPRGAQAGRPPREGATERREVRGAGRGAGPRRGRGQARRRPERRAARLRGGRTGERRTARVGRPRGARPEAAAGDPGAWRPRRWGRPGARCAPRAGSWGRGRRRRGTRGGGPPCCPSGDSCPREPLRKKKKVDPKKDQAAKERLKKRIRRLEKATQELIPIEDFITPVKFLNQARQRPPVELPFEESERRALLLKKWSLYKQREHELERAAIASLLEAQREALQELELTAPELHAEATKRDSSLFPFERQGPDYTPPIANYQPPEGRYQDITKVYTQVEFKR", "length": 485, "header": "tr|A0AAA9SEM5-1|A0AAA9SEM5_BOVIN Isoform 1 of Large ribosomal subunit protein mL40 OS=Bos taurus OX=9913 GN=MRPL40 PE=3 SV=1 CANONICAL=A0AAA9SEM5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5/entry#A0AAA9SEM5-1", "sequence": { "sequence": "MEPPPPPALRPPPAPRPQRRRAIAGPRPPPPPPQPPPALGRRRRRHSRIPRAAPPPAAPGQRRKSRRAPAKRPRRETAPRVLGPRGSRAGRPAGRAGGRRRVGSAPGGGGEGGPAGGARAGGRAGLGGAGGGRCPGGARRANWRAHAAPGALSLGTRAREPRAAQRPGPDAGGRAAAFTACPARLAREGFRAPGRRRPRRARHGPRGAQAGRPPREGATERREVRGAGRGAGPRRGRGQARRRPERRAARLRGGRTGERRTARVGRPRGARPEAAAGDPGAWRPRRWGRPGARCAPRAGSWGRGRRRRGTRGGGPPCCPSGDSCPREPLRKKKKVDPKKDQAAKERLKKRIRRLEKATQELIPIEDFITPVKFLNQARQRPPVELPFEESERRALLLKKWSLYKQREHELERAAIASLLEAQREALQELELTAPELHAEATKRDSSLFPFERQGPDYTPPIANYQPPEGRYQDITKVYTQVEFKR", "length": 485, "header": "tr|A0AAA9SEM5-1|A0AAA9SEM5_BOVIN Isoform 1 of Large ribosomal subunit protein mL40 OS=Bos taurus OX=9913 GN=MRPL40 PE=3 SV=1 CANONICAL=A0AAA9SEM5-1" }, "locus": { "chromosome": "17", "start_pos": 72696271, "end_pos": 72693030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123928.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123928.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083848.1" } ] } }, { "isoform_ac": "F1N1R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5/entry#F1N1R3-1", "sequence": { "sequence": "MGPQRALSEHTPVSRGPHPRGADAPTRCERSPAGWGASARRHGAPLRGTASGSSPGLLGARPTQTGDARRRASLLSFWGLVPTRAEPLRKKKKVDPKKDQAAKERLKKRIRRLEKATQELIPIEDFITPVKFLNQARQRPPVELPFEESERRALLLKKWSLYKQREHELERAAIASLLEAQREALQELELTAPELHAEATKRDSSLFPFERQGPDYTPPIANYQPPEGRYQDITKVYTQVEFKR", "length": 244, "header": "tr|F1N1R3-1|A0AAA9SEM5_BOVIN Computationally mapped isoform of Large ribosomal subunit protein mL40 OS=Bos taurus OX=9913 GN=MRPL40 PE=3 SV=3 CANONICAL=A0AAA9SEM5-1" }, "locus": { "chromosome": "17", "start_pos": 72696271, "end_pos": 72692430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026501.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026501.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026501.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026501.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5" } ], "pmid": "" }, { "name": "mitochondrial ribosome", "id": "GO:0005761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005761", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGR5-1", "uniprot_ac": "A0AAA9SGR5", "uniprot_id": "A0AAA9SGR5_BOVIN", "mass": { "chemical_mass": 51225.0, "monoisotopic_mass": 51225.0 }, "refseq": {}, "gene_names": [ { "name": "RDH13", "type": "recommended", "evidence": [ { "id": "A0AAA9SGR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5" } ] } ], "protein_names": [ { "name": "Retinol dehydrogenase 13", "type": "synonym", "evidence": [ { "id": "A0AAA9SGR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RDH13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5", "locus": { "chromosome": "18", "start_pos": 62370299, "end_pos": 62338040, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030393", "url": "https://www.ensembl.org/id/ENSBTAG00000030393" } ] } } ], "crossref": [ { "id": "A0AAA9SGR5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43157:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43157:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PY02", "url": "https://www.uniprot.org/uniprotkb/F6PY02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PY02-1", "url": "https://www.uniprot.org/uniprotkb/F6PY02-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLESPYCTEELVFQATSWTDPHCSPSNSQAGSFPTEPSGKPCGRKAGLCGGPVSHIFVAGKSRQETRSVLPGPRDLGTDRKLPDLQLFPIGADESRRKCSGFELMQKENTAEIDVQNADTENRGHLRRPQTYLKSTKTLLKKDPLPSCLGLLPSSSSRSSSSSSFSSACAAVEANRVPLIMRPRANRILTALTLAWTSQKKIPTMSRCTSHQRRTGRGTCR", "length": 472, "header": "tr|A0AAA9SGR5-1|A0AAA9SGR5_BOVIN Isoform 1 of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#A0AAA9SEN4-1", "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLESPYCTEELVFQATSWTDPHCSPSNSQAGSFPTEPSGKPCGRKAGLCGGPVSHIFVAGKSRQETRR", "length": 319, "header": "tr|A0AAA9SEN4-1|A0AAA9SGR5_BOVIN Computationally mapped isoform of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "locus": { "chromosome": "18", "start_pos": 62365095, "end_pos": 62338157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098940.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098940.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082076.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082076.1" } ] } }, { "isoform_ac": "A0AAA9SGR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#A0AAA9SGR5-1", "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLESPYCTEELVFQATSWTDPHCSPSNSQAGSFPTEPSGKPCGRKAGLCGGPVSHIFVAGKSRQETRSVLPGPRDLGTDRKLPDLQLFPIGADESRRKCSGFELMQKENTAEIDVQNADTENRGHLRRPQTYLKSTKTLLKKDPLPSCLGLLPSSSSRSSSSSSFSSACAAVEANRVPLIMRPRANRILTALTLAWTSQKKIPTMSRCTSHQRRTGRGTCR", "length": 472, "header": "tr|A0AAA9SGR5-1|A0AAA9SGR5_BOVIN Isoform 1 of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "locus": { "chromosome": "18", "start_pos": 62370298, "end_pos": 62338157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123103.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123103.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083074.1" } ] } }, { "isoform_ac": "A0AAA9SPH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#A0AAA9SPH0-1", "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLESPYCTEELVFQATSWTDPHCSPSNSQTYLKSTKTLLKKDPLPSCLGLLPSSSSRSSSSSSFSSACAAVEANRVPLIMRPRANRILTALTLAWTSQKKIPTMSRCTSHQRRTGRGTCR", "length": 371, "header": "tr|A0AAA9SPH0-1|A0AAA9SPH0_BOVIN Computationally mapped isoform of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "locus": { "chromosome": "18", "start_pos": 62370298, "end_pos": 62338157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088191.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088191.1" } ] } }, { "isoform_ac": "A0AAA9TA70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#A0AAA9TA70-1", "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLESPYCTEELVFQATSWTDPHCSPSNSQAGSFPTEPSGKPCGRKAGLCGGPVSHIFVAGKSRQETRSVLPGPRDLGTDRAQALGCQASVDAAPGL", "length": 347, "header": "tr|A0AAA9TA70-1|A0AAA9TA70_BOVIN Computationally mapped isoform of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "locus": { "chromosome": "18", "start_pos": 62365829, "end_pos": 62338157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087719.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087719.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092859.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092859.1" } ] } }, { "isoform_ac": "A0AAA9TGT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#A0AAA9TGT3-1", "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLESPYCTEELVFQATSWTDPHCSPSNSQAGSFPTEPSGKPCGRKAGLCGGPVSHIFVAGKSRQETRSVLPGPRDLGTDRVTWSSRRQTTDLYCPPTPRPT", "length": 352, "header": "tr|A0AAA9TGT3-1|A0AAA9TGT3_BOVIN Computationally mapped isoform of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "locus": { "chromosome": "18", "start_pos": 62369002, "end_pos": 62338157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133578.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133578.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095423.1" } ] } }, { "isoform_ac": "F6PY02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5/entry#F6PY02-1", "sequence": { "sequence": "MSRYVLPLSVLGTAVGGAVLLKDFVAGGACPSKATIPGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKEIRGETLNHRVNARHLDLASLKSIREFAAKVTEEEEHVHILINNAAVMRCPHWTTEDGFEMQLGVNYLGAAAALCWSSREEIPHIQGHFLLTNLLLDKLKASAPSRIINVSSLAHVAGHIDFEDLNWEKRKYDTKAAYCQSKLAVVVSTKELSRRLQGTGVTVNALHPGVARTELGRHTGMHSSAFSSFTLGPIFWLLVKSPELAAQPSVYLAVAEELEGVSGKYFDVLKEKPPAPEAEDEEVAKRLWAESVRLVGLEMSHGSHGKTGQPLPK", "length": 353, "header": "tr|F6PY02-1|F6PY02_BOVIN Computationally mapped isoform of Retinol dehydrogenase 13 OS=Bos taurus OX=9913 GN=RDH13 PE=3 SV=1 CANONICAL=A0AAA9SGR5-1" }, "locus": { "chromosome": "18", "start_pos": 62353198, "end_pos": 62338157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029403.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029403.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029403.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029403.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5" } ], "pmid": "" }, { "name": "all-trans-retinol dehydrogenase (NADP+) activity", "id": "GO:0052650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "retinal metabolic process", "id": "GO:0042574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042574", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEQ2-1", "uniprot_ac": "A0AAA9SEQ2", "uniprot_id": "A0AAA9SEQ2_BOVIN", "mass": { "chemical_mass": 70982.0, "monoisotopic_mass": 70982.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC43", "type": "recommended", "evidence": [ { "id": "A0AAA9SEQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 43", "type": "synonym", "evidence": [ { "id": "A0AAA9SEQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2", "locus": { "chromosome": "17", "start_pos": 53178771, "end_pos": 53194738, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004192", "url": "https://www.ensembl.org/id/ENSBTAG00000004192" } ] } } ], "crossref": [ { "id": "A0AAA9SEQ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004192", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004192", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28328", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28328", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N285", "url": "https://www.uniprot.org/uniprotkb/G3N285", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N285-1", "url": "https://www.uniprot.org/uniprotkb/G3N285-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPETRTLSAAVREHLRQLCLHEFPCGTGSWNKSRFLPQTSRVWRELIPREEKSLSPGEETVEDLLGLVRSAHSPWALVEGSSAEDLFLKELAIQNPLMLKDSFFYTYFRSLRVVDKDVSLVDKELLKFVKLEELVLSANQIKEIDTTNLPPTLKVLELYGNKIASMECLCRHPPPRLQHLGLGHNKLLGPLESLHVTSDHWPNLVSLDLSFNNLTDLQNMVAGLQTLKHLRLLLLQGNPLALVPHYRGFTIDSLARLCVLDDITVASSEKHLFRGLSRSEDLLAPEAQLLVTVGNLRGVLDSSVLDSEPGPQGPFITYNYYVTYDFVEDEEGEGSQYGGVLAEIIKPPSSLEQLGEDILEEIIEDVEESLESGLASLSELGEMEESIVSGASEPLPRSTDSAEELAKLRPLLDPRLCPSPGTVLFSTVPKPWSDVIPCNYEMQHTLKDLVPLKAFLLSGTVVTVVEEKILSWPVEQPSSSDSPLAAKKGKGEKDKKEKEKDKKDKAGKGEKEPPKAQKGSKKQKELPKELRQDPPILRVLGSSPVVLEPLLAGEPFVSTVCNFGVIRTLEADRLTLNRDAKKNKKGKKAALEVKSKTKMPAAPVYENDYQPEPLTVEIQIQLIQWRSTEEALRGLVM", "length": 638, "header": "tr|A0AAA9SEQ2-1|A0AAA9SEQ2_BOVIN Isoform 1 of Leucine rich repeat containing 43 OS=Bos taurus OX=9913 GN=LRRC43 PE=4 SV=1 CANONICAL=A0AAA9SEQ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2/entry#A0AAA9SEQ2-1", "sequence": { "sequence": "MEPETRTLSAAVREHLRQLCLHEFPCGTGSWNKSRFLPQTSRVWRELIPREEKSLSPGEETVEDLLGLVRSAHSPWALVEGSSAEDLFLKELAIQNPLMLKDSFFYTYFRSLRVVDKDVSLVDKELLKFVKLEELVLSANQIKEIDTTNLPPTLKVLELYGNKIASMECLCRHPPPRLQHLGLGHNKLLGPLESLHVTSDHWPNLVSLDLSFNNLTDLQNMVAGLQTLKHLRLLLLQGNPLALVPHYRGFTIDSLARLCVLDDITVASSEKHLFRGLSRSEDLLAPEAQLLVTVGNLRGVLDSSVLDSEPGPQGPFITYNYYVTYDFVEDEEGEGSQYGGVLAEIIKPPSSLEQLGEDILEEIIEDVEESLESGLASLSELGEMEESIVSGASEPLPRSTDSAEELAKLRPLLDPRLCPSPGTVLFSTVPKPWSDVIPCNYEMQHTLKDLVPLKAFLLSGTVVTVVEEKILSWPVEQPSSSDSPLAAKKGKGEKDKKEKEKDKKDKAGKGEKEPPKAQKGSKKQKELPKELRQDPPILRVLGSSPVVLEPLLAGEPFVSTVCNFGVIRTLEADRLTLNRDAKKNKKGKKAALEVKSKTKMPAAPVYENDYQPEPLTVEIQIQLIQWRSTEEALRGLVM", "length": 638, "header": "tr|A0AAA9SEQ2-1|A0AAA9SEQ2_BOVIN Isoform 1 of Leucine rich repeat containing 43 OS=Bos taurus OX=9913 GN=LRRC43 PE=4 SV=1 CANONICAL=A0AAA9SEQ2-1" }, "locus": { "chromosome": "17", "start_pos": 53194563, "end_pos": 53179291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122099.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122099.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080878.1" } ] } }, { "isoform_ac": "G3N285-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2/entry#G3N285-1", "sequence": { "sequence": "MEPETRTLSAAVREHLRQLCLHEFPCGTGSWNKSRFLPQTSRVWRELIPREEKSLSPGEETVEDLLGLVRSAHSPWALVEGSSAEDLFLKELAIQNPLMLKDSFFYTYFRSLRVVDKDVSLVDKELLKFVKLEELVLSANQIKEIDTTNLPPTLKVLELYGNKIASMECLCRHPPPRLQHLGLGHNKLLGPLESLHVTSDHWPNLVSLDLSFNNLTDLQNMVAGLQTLKHLRLLLLQGNPLALVPHYRGFTIDSLARLCVLDDITVASSEKHLFRGLSRSEDLLAPEAQLLVTVGNLRGVLDSSVLDSEPGPQGPFITYNYYVTYDFVEDEEGEGSQYGGVLAEIIKPPSSLEQLGEDILEEIIEDVEESLESGLASLSELGEMEESIVSGASEPLPRSTDSAEELAKLRPLLDPRLCPSPGTVLFSTVPKPWSDVIPCNYEMQHTLKDLVPLKAFLLSGTVVTVVEEKILSWPVEQPSSSDSPLAAKKGKGEKDKKEKEKDKKDKAGKGEKEPPKAQKGSKKQKELPKELRQDPPILRVLGSSPVVLEPLLAGEPFVSTVCNFGVIRTLEADRLTLNRDAKKNKKGKKVYENDYQPEPLTVEIQIQLIQWRSTEEALRGLVM", "length": 623, "header": "tr|G3N285-1|G3N285_BOVIN Computationally mapped isoform of Leucine rich repeat containing 43 OS=Bos taurus OX=9913 GN=LRRC43 PE=4 SV=3 CANONICAL=A0AAA9SEQ2-1" }, "locus": { "chromosome": "17", "start_pos": 53194563, "end_pos": 53179291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063215.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063215.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055995.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055995.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2" }, { "id": "PF28335", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28335" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Leucine-rich repeat-containing protein 43 C-terminal", "eco_id": "ECO_0000259", "start_pos": 288, "end_pos": 637, "start_aa": "Ala", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SEQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ2" }, { "id": "PF28328", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28328" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Leucine-rich repeat-containing protein 43 N-terminal", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 100, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 }, { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SET7-1", "uniprot_ac": "A0AAA9SET7", "uniprot_id": "A0AAA9SET7_BOVIN", "mass": { "chemical_mass": 7727.0, "monoisotopic_mass": 7727.0 }, "refseq": { "ac": "XP_024840918", "name": "salivary gland specific protein SAGSIN1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840918" }, "gene_names": [ { "name": "SMIM10L3", "type": "recommended", "evidence": [ { "id": "A0AAA9SET7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7" } ] }, { "name": "SMIM10L3", "type": "synonym", "evidence": [ { "id": "XP_024840918", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840918" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 10 like 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SET7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7/entry#names_and_taxonomy" } ] }, { "name": "salivary gland specific protein SAGSIN1", "type": "synonym", "evidence": [ { "id": "XP_024840918", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840918" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SET7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM10L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7", "locus": { "chromosome": "25", "start_pos": 38240706, "end_pos": 38253773, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069828", "url": "https://www.ensembl.org/id/ENSBTAG00000069828" } ] } } ], "crossref": [ { "id": "A0AAA9SET7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SET7", "database": "AlphaFoldDB", "categories": [] }, { "id": "100140431", "url": "https://www.ncbi.nlm.nih.gov/gene/100140431", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140431", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140431", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR34446", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34446", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34446:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34446:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840918", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840918", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SET7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SET7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAALSGLAVRLSRSAAARSYGVFCKGLTRTLLIFFDLAWRLRINFPYLYIVASMMLNVRLQVHIEIH", "length": 68, "header": "tr|A0AAA9SET7-1|A0AAA9SET7_BOVIN Isoform 1 of Small integral membrane protein 10 like 3 OS=Bos taurus OX=9913 GN=SMIM10L3 PE=4 SV=1 CANONICAL=A0AAA9SET7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SET7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SET7/entry#A0AAA9SET7-1", "sequence": { "sequence": "MAAALSGLAVRLSRSAAARSYGVFCKGLTRTLLIFFDLAWRLRINFPYLYIVASMMLNVRLQVHIEIH", "length": 68, "header": "tr|A0AAA9SET7-1|A0AAA9SET7_BOVIN Isoform 1 of Small integral membrane protein 10 like 3 OS=Bos taurus OX=9913 GN=SMIM10L3 PE=4 SV=1 CANONICAL=A0AAA9SET7-1" }, "locus": { "chromosome": "25", "start_pos": 38253574, "end_pos": 38241710, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109989.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109989.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080929.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080929.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140431", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140431", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEV2-1", "uniprot_ac": "A0AAA9SEV2", "uniprot_id": "A0AAA9SEV2_BOVIN", "mass": { "chemical_mass": 24937.0, "monoisotopic_mass": 24937.0 }, "refseq": {}, "gene_names": [ { "name": "SMCO2", "type": "recommended", "evidence": [ { "id": "A0AAA9SEV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2" } ] } ], "protein_names": [ { "name": "Single-pass membrane protein with coiled-coil domains 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SEV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMCO2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SEV2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22422", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22422", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22422:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22422:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "KLELKAGHGQDLQNEQDEQERDHIQHEDPQASTSLQFSEENILEHLLSEVVSLEGQIEKLESHQDLDSDQGVNMEEDACDEAHKLKEKLVARIENFCKDMALLDTKLGMYQMQGNPDSQSPEEMGMDEKEPLLLQASSPSLEESSPPHITMWKCALRIFIMFYVLTLTGLSCYILFFDATFIFEKVLPTILGRRRMWELREILAPFLNLEVEDLLPS", "length": 217, "header": "tr|A0AAA9SEV2-1|A0AAA9SEV2_BOVIN Isoform 1 of Single-pass membrane protein with coiled-coil domains 2 OS=Bos taurus OX=9913 GN=SMCO2 PE=4 SV=1 CANONICAL=A0AAA9SEV2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2/entry#A0AAA9SEV2-1", "sequence": { "sequence": "KLELKAGHGQDLQNEQDEQERDHIQHEDPQASTSLQFSEENILEHLLSEVVSLEGQIEKLESHQDLDSDQGVNMEEDACDEAHKLKEKLVARIENFCKDMALLDTKLGMYQMQGNPDSQSPEEMGMDEKEPLLLQASSPSLEESSPPHITMWKCALRIFIMFYVLTLTGLSCYILFFDATFIFEKVLPTILGRRRMWELREILAPFLNLEVEDLLPS", "length": 217, "header": "tr|A0AAA9SEV2-1|A0AAA9SEV2_BOVIN Isoform 1 of Single-pass membrane protein with coiled-coil domains 2 OS=Bos taurus OX=9913 GN=SMCO2 PE=4 SV=1 CANONICAL=A0AAA9SEV2-1" }, "locus": { "chromosome": "5", "start_pos": 82397905, "end_pos": 82373289, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112618.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112618.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080949.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080949.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEV5-1", "uniprot_ac": "A0AAA9SEV5", "uniprot_id": "A0AAA9SEV5_BOVIN", "mass": { "chemical_mass": 11818.0, "monoisotopic_mass": 11818.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SEV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SEV5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AQSVTQDQPDILSEVGKAVTLNCRYETSWYMLSYYIFWYKQLPSGQMTYLIRQYSDDGNARDGRYSVNFQKAQKSINLTISALELEDSAMYFCVLRASQCLK", "length": 102, "header": "tr|A0AAA9SEV5-1|A0AAA9SEV5_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SEV5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5/entry#A0AAA9SEV5-1", "sequence": { "sequence": "AQSVTQDQPDILSEVGKAVTLNCRYETSWYMLSYYIFWYKQLPSGQMTYLIRQYSDDGNARDGRYSVNFQKAQKSINLTISALELEDSAMYFCVLRASQCLK", "length": 102, "header": "tr|A0AAA9SEV5-1|A0AAA9SEV5_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SEV5-1" }, "locus": { "chromosome": "NKLS02001214.1", "start_pos": 153007, "end_pos": 152702, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083927.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 102, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEX7-1", "uniprot_ac": "A0AAA9SEX7", "uniprot_id": "A0AAA9SEX7_BOVIN", "mass": { "chemical_mass": 20364.0, "monoisotopic_mass": 20364.0 }, "refseq": {}, "gene_names": [ { "name": "EDN2", "type": "recommended", "evidence": [ { "id": "A0AAA9SEX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ] } ], "protein_names": [ { "name": "Endothelin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SEX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7/entry#names_and_taxonomy" } ] }, { "name": "Preproendothelin-2", "type": "synonym", "evidence": [ { "id": "A0AAA9SEX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Endothelins are endothelium-derived vasoconstrictor peptides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA5#function" }, { "database": "UniProtKB", "id": "ARBA00003023", "url": "https://www.uniprot.org/uniprotkb/ARBA00003023#function" }, { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7#function" }, { "database": "UniProtKB", "id": "A0AAF6Z8Y8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Y8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EDN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7", "locus": { "chromosome": "3", "start_pos": 104706947, "end_pos": 104694669, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021434", "url": "https://www.ensembl.org/id/ENSBTAG00000021434" } ] } } ], "crossref": [ { "id": "A0AAA9SEX7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13874", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13874", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13874:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13874:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00322", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00322", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8Y8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Y8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8Y8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8Y8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SGFPGAGRAGPKPQGKEVSWAHLCSGKSQAATTPIPEQPAPLPRARGSHLRTRRCSCSSWLDKECVYFCHLDIIWVNTPGQTAPYGLGNPPRRRRRSLPRRCECYSARDPACATFCHQRPWTDAVAVPGSGSPAAAFQDGKTQATAGELLQRLRVISATKIHFARQQQKPTRETRPTHSRQRKR", "length": 184, "header": "tr|A0AAA9SEX7-1|A0AAA9SEX7_BOVIN Isoform 1 of Endothelin-2 OS=Bos taurus OX=9913 GN=EDN2 PE=3 SV=1 CANONICAL=A0AAA9SEX7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7/entry#A0AAA9SEX7-1", "sequence": { "sequence": "SGFPGAGRAGPKPQGKEVSWAHLCSGKSQAATTPIPEQPAPLPRARGSHLRTRRCSCSSWLDKECVYFCHLDIIWVNTPGQTAPYGLGNPPRRRRRSLPRRCECYSARDPACATFCHQRPWTDAVAVPGSGSPAAAFQDGKTQATAGELLQRLRVISATKIHFARQQQKPTRETRPTHSRQRKR", "length": 184, "header": "tr|A0AAA9SEX7-1|A0AAA9SEX7_BOVIN Isoform 1 of Endothelin-2 OS=Bos taurus OX=9913 GN=EDN2 PE=3 SV=1 CANONICAL=A0AAA9SEX7-1" }, "locus": { "chromosome": "3", "start_pos": 104706323, "end_pos": 104694670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132893.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132893.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080981.1" } ] } }, { "isoform_ac": "A0AAA9SZA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7/entry#A0AAA9SZA5-1", "sequence": { "sequence": "SVGTRAKELRAHAARSARRHRGKSQAATTPIPEQPAPLPRARGSHLRTRRCSCSSWLDKECVYFCHLDIIWVNTPGQTAPYGLGNPPRRRRRSLPRRCECYSARDPACATFCHQRPWTDAVAVPGSGSPAAAFQDGKTQATAGELLQRLRVISATKIHFARQQQKPTRETRPTHSRQRKR", "length": 180, "header": "tr|A0AAA9SZA5-1|A0AAA9SZA5_BOVIN Computationally mapped isoform of Endothelin-2 OS=Bos taurus OX=9913 GN=EDN2 PE=3 SV=1 CANONICAL=A0AAA9SEX7-1" }, "locus": { "chromosome": "3", "start_pos": 104706323, "end_pos": 104698287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112094.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112094.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089629.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089629.1" } ] } }, { "isoform_ac": "A0AAF6Z8Y8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7/entry#A0AAF6Z8Y8-1", "sequence": { "sequence": "VVAMPTALCSIALALLVALHEGKSQAATTPIPEQPAPLPRARGSHLRTRRCSCSSWLDKECVYFCHLDIIWVNTPGQTAPYGLGNPPRRRRRSLPRRCECYSARDPACATFCHQRPWTDAVAVPGSGSPAAAFQDGKTQATAGELLQRLRVISATKIHFARQQQKPTRETRPTHSRQRKR", "length": 180, "header": "tr|A0AAF6Z8Y8-1|A0AAF6Z8Y8_BOVIN Computationally mapped isoform of Endothelin-2 OS=Bos taurus OX=9913 GN=EDN2 PE=3 SV=1 CANONICAL=A0AAA9SEX7-1" }, "locus": { "chromosome": "3", "start_pos": 104706323, "end_pos": 104701108, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028571.4", "url": "https://www.ensembl.org/id/ENSBTAT00000028571.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028571.3", "url": "https://www.ensembl.org/id/ENSBTAP00000028571.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "endothelin receptor signaling pathway", "id": "GO:0086100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086100", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "regulation of vasoconstriction", "id": "GO:0019229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019229", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "positive regulation of heart rate", "id": "GO:0010460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010460", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "positive regulation of calcium-mediated signaling", "id": "GO:0050850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050850", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "artery smooth muscle contraction", "id": "GO:0014824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014824", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "positive regulation of leukocyte chemotaxis", "id": "GO:0002690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002690", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "regulation of systemic arterial blood pressure by endothelin", "id": "GO:0003100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003100", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "vein smooth muscle contraction", "id": "GO:0014826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "macrophage activation", "id": "GO:0042116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "macrophage chemotaxis", "id": "GO:0048246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "neutrophil chemotaxis", "id": "GO:0030593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "cell tip growth", "id": "GO:0009932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "vasoconstriction", "id": "GO:0042310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" }, { "name": "endothelin B receptor binding", "id": "GO:0031708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031708", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX7" }, { "id": "SM00272", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00272" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Endothelin-like toxin", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 75, "start_aa": "Arg", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEY3-1", "uniprot_ac": "A0AAA9SEY3", "uniprot_id": "A0AAA9SEY3_BOVIN", "mass": { "chemical_mass": 25981.0, "monoisotopic_mass": 25981.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3/entry#names_and_taxonomy" } ] }, { "name": "7.1.1.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3/entry#names_and_taxonomy" } ] }, { "name": "NADH-ubiquinone oxidoreductase 24 kDa subunit", "type": "synonym", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3#function" }, { "database": "UniProtKB", "id": "ARBA00045293", "url": "https://www.uniprot.org/uniprotkb/ARBA00045293#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SEY3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEY3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03064", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03064", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041921", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041921", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10371", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10371", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10371:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10371:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FFSLHVPLHGATGRVAGLAAHWGKHIRNLHKTANNSETPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNNVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPLKGPGFGVQAGL", "length": 236, "header": "tr|A0AAA9SEY3-1|A0AAA9SEY3_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SEY3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3/entry#A0AAA9SEY3-1", "sequence": { "sequence": "FFSLHVPLHGATGRVAGLAAHWGKHIRNLHKTANNSETPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNNVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPLKGPGFGVQAGL", "length": 236, "header": "tr|A0AAA9SEY3-1|A0AAA9SEY3_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SEY3-1" }, "locus": { "chromosome": "X", "start_pos": 77048404, "end_pos": 77047499, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067553.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067553.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084713.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084713.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ], "pmid": "" }, { "name": "NADH dehydrogenase (ubiquinone) activity", "id": "GO:0008137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008137", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29091", "name": "", "equation": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6QTH1-1", "Q85BD6-1", "A0AAA9SEY3-1", "A0AAA9TZL3-1", "P03920-1", "P03887-1", "P03892-1", "P03898-1", "P03902-1", "P03910-1", "P03924-1", "P04394-1", "P15690-1", "P17694-1", "P23709-1", "P25708-1", "P42026-1", "P42028-1", "Q6QTH0-1" ], "evidence": [ { "id": "29091", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29091" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SEY3", "gene_name": "", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] } ] }, { "uniprot_ac": "A0AAA9TZL3", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] } ] }, { "uniprot_ac": "P03887", "gene_name": "MT-ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] } ] }, { "uniprot_ac": "P03892", "gene_name": "MT-ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] } ] }, { "uniprot_ac": "P03898", "gene_name": "MT-ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] } ] }, { "uniprot_ac": "P03902", "gene_name": "MT-ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03902" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03902" } ] } ] }, { "uniprot_ac": "P03910", "gene_name": "MT-ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] } ] }, { "uniprot_ac": "P03920", "gene_name": "MT-ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03920" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03920" } ] } ] }, { "uniprot_ac": "P03924", "gene_name": "MT-ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] } ] }, { "uniprot_ac": "P04394", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P17694", "gene_name": "NDUFS2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] } ] }, { "uniprot_ac": "P23709", "gene_name": "NDUFS3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P23709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23709" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P23709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P23709" } ] } ] }, { "uniprot_ac": "P25708", "gene_name": "NDUFV1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] } ] }, { "uniprot_ac": "P42026", "gene_name": "NDUFS7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] } ] }, { "uniprot_ac": "P42028", "gene_name": "NDUFS8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] } ] }, { "uniprot_ac": "Q6QTH0", "gene_name": "ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] } ] }, { "uniprot_ac": "Q6QTH1", "gene_name": "ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] } ] }, { "uniprot_ac": "Q85BD6", "gene_name": "ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.1.1.2", "ec_name": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "7.1.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2" }, { "id": "7.1.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.1.1.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 34, "end_pos": 36 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEY8-1", "uniprot_ac": "A0AAA9SEY8", "uniprot_id": "A0AAA9SEY8_BOVIN", "mass": { "chemical_mass": 47871.0, "monoisotopic_mass": 47871.0 }, "refseq": { "ac": "XP_002687391", "name": "zinc finger protein 641 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687391" }, "gene_names": [ { "name": "ZNF641", "type": "recommended", "evidence": [ { "id": "A0AAA9SEY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ] }, { "name": "ZNF641", "type": "synonym", "evidence": [ { "id": "XP_002687391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687391" } ] } ], "protein_names": [ { "name": "Zinc finger protein 641", "type": "recommended", "evidence": [ { "id": "A0AAA9SEY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 641 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687391" } ] } ], "function": [ { "annotation": "Transcriptional activator. Activates transcriptional activities of SRE and AP-1.", "evidence": [ { "database": "UniProtKB", "id": "E1BNN9", "url": "https://www.uniprot.org/uniprotkb/E1BNN9#function" }, { "database": "UniProtKB", "id": "ARBA00057326", "url": "https://www.uniprot.org/uniprotkb/ARBA00057326#function" }, { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF641", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8", "locus": { "chromosome": "5", "start_pos": 31939045, "end_pos": 31930141, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016496", "url": "https://www.ensembl.org/id/ENSBTAG00000016496" } ] } } ], "crossref": [ { "id": "A0AAA9SEY8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016496", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016496", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538714", "url": "https://www.ncbi.nlm.nih.gov/gene/538714", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538714", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538714", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WESMNIQ", "url": "https://omabrowser.org/oma/group/WESMNIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BNN9", "url": "https://www.orthodb.org/?gene=E1BNN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687391", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687391", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNN9", "url": "https://www.uniprot.org/uniprotkb/E1BNN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BNN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSEQTAALGTGWESMNVQVDRAEPQVERGSQEEGPWRTAPGPLEHLCCDLEEEPQSLQEKAQSTPWVPAIPQEGSTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPPDLEERDILKVTYTGDGSEHEGDTPELEAEPPRMLSSVSQDTVLWNPEQDANWDSMPRSSRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCPECGKNFRCNSHLASHQRVHADGKSCKGQEVGESPGARKRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLLTHQGQSPRSSWDRGTSVF", "length": 424, "header": "tr|A0AAA9SEY8-1|A0AAA9SEY8_BOVIN Isoform 1 of Zinc finger protein 641 OS=Bos taurus OX=9913 GN=ZNF641 PE=3 SV=1 CANONICAL=A0AAA9SEY8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8/entry#A0AAA9SEY8-1", "sequence": { "sequence": "MLSEQTAALGTGWESMNVQVDRAEPQVERGSQEEGPWRTAPGPLEHLCCDLEEEPQSLQEKAQSTPWVPAIPQEGSTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPPDLEERDILKVTYTGDGSEHEGDTPELEAEPPRMLSSVSQDTVLWNPEQDANWDSMPRSSRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCPECGKNFRCNSHLASHQRVHADGKSCKGQEVGESPGARKRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLLTHQGQSPRSSWDRGTSVF", "length": 424, "header": "tr|A0AAA9SEY8-1|A0AAA9SEY8_BOVIN Isoform 1 of Zinc finger protein 641 OS=Bos taurus OX=9913 GN=ZNF641 PE=3 SV=1 CANONICAL=A0AAA9SEY8-1" }, "locus": { "chromosome": "5", "start_pos": 31938041, "end_pos": 31932974, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098863.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098863.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084719.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084719.1" } ] } }, { "isoform_ac": "E1BNN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8/entry#E1BNN9-1", "sequence": { "sequence": "RQSEDKSQFGFAAKMLSEQTAALGTGWESMNVQVDRAEPQVERGSQEEGPWRTAPGPLEHLCCDLEEEPQSLQEKAQSTPWVPAIPQEGSTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPPDLEERDILKVTYTGDGSEHEGDTPELEAEPPRMLSSVSQDTVLWNPEQDANWDSMPRSSRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCPECGKNFRCNSHLASHQRVHADGKSCKGQEVGESPGARKRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLLTHQGQSPRSSWDRGTSVF", "length": 438, "header": "tr|E1BNN9-1|E1BNN9_BOVIN Computationally mapped isoform of Zinc finger protein 641 OS=Bos taurus OX=9913 GN=ZNF641 PE=3 SV=4 CANONICAL=A0AAA9SEY8-1" }, "locus": { "chromosome": "5", "start_pos": 31938041, "end_pos": 31931038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021929.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021929.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021929.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021929.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538714", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538714", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T9T7-1", "protein_name": "Zinc finger protein 641", "gene_name": "ZNF641", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSEQTAALGTGWESVNVQLDGAEPQVERGSQEEGPWRTAPGPLEHLCCDLEEEPQSLQEKGQSAPWAPTIPQEGSTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPQDLEERDILRVTYTGDGSEHEGDTPEPEAEPPRMLSSVSEDTALWSPEQDERWDSMPRSSRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCSECGKNFRCNSHLASHQRVHAEGKSCKGQEAGESPGARKRQRAVPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLLTHQGQSPRSSWDRGTSVF", "length": 424 }, "evidence": [ { "id": "A0AAA9SEY8", "url": "https://omabrowser.org/oma/group/A0AAA9SEY8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A704-1", "protein_name": "Zinc finger protein 641", "gene_name": "Zfp641", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSEQSVAPGAGWEPMSAQLDAAEPGSERGAREEGPWRTAPRPLEHLHSGLEDETLSLQEKAPSAPWVPAVPQEGDTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLPQLEGGEEQWVPDPQDVEGRDIRKVTYAGDGGEPKGDTPELETEPSRTLSSMSEETVLWNPGQGPSWRSMPSSSTGTLPRPRFLQEDSVSHLLRSTDTDSLLKPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCPECGKTFRCSSHLASHQRVHADSKSCKGQEIGESPGAQCAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFHCPRCEKSFGRKHHLDRHLLTHQGQSPGSSWDRGTSAF", "length": 421 }, "evidence": [ { "id": "A0AAA9SEY8", "url": "https://omabrowser.org/oma/group/A0AAA9SEY8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BZ34-1", "protein_name": "Zinc finger protein 641", "gene_name": "Znf641", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSEQAVGLGTGWEPMNTQLDAAELQSERGTREEGSWRTAPRPLEHLHCGLEDEPLSLQEKATSVPWVPAVPQEGNTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQQEGGEDQWAPDPQDVEGRDILKVTYTGDGGEPQGDTPELQVEPPRTLSSVTEDTALWNPGQGPSWESMPRNSTGMLLSPRFLQEDTFSRHLHRTDTDSLLKPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCSECGKSFRCSSHLASHQRVHADSKSCKGQDFGESPAAQHCVPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFHCPRCEKSFGRKHHLDRHLLTHQGQSPGSSWDRRTAAF", "length": 422 }, "evidence": [ { "id": "A0AAA9SEY8", "url": "https://omabrowser.org/oma/group/A0AAA9SEY8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96N77-1", "protein_name": "Zinc finger protein 641", "gene_name": "ZNF641", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQAEDRSQFGSAAEMLSEQTAALGTGWESMNVQLDGAEPQVERGSQEERPWRTVPGPLEHLCCDLEEEPQSLQEKAQSAPWVPAIPQEGNTGDWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPQDLEERDILRVTYTGDGSEHEGDTPELEAEPPRMLSSVSEDTVLWNPEHDESWDSMPSSSRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKTFGRRHHLIRHQKTHLHDKTSRCSECGKNFRCNSHLASHQRVHAEGKSCKGQEVGESPGTRKRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCEKSFGRKHHLDRHLLTHQGQSPRNSWDRGTSVF", "length": 438 }, "evidence": [ { "id": "A0AAA9SEY8", "url": "https://omabrowser.org/oma/group/A0AAA9SEY8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 250, "end_pos": 277, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SEY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY8" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 167, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF12-1", "uniprot_ac": "A0AAA9SF12", "uniprot_id": "A0AAA9SF12_BOVIN", "mass": { "chemical_mass": 12267.0, "monoisotopic_mass": 12267.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SF12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF12/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF12", "locus": {} } ], "crossref": [ { "id": "A0AAA9SF12", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SF12", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SF12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGKYVDSEGCLDKAPSSLPLPLPTTSRRSGSAWVWKPSFPKRSRRRSATGQGSGSDLRVGLRNCAGTSLHCSHPGTGQHLQAQQQGYGRGNEREASVRRAHQGDRSGQPRPQ", "length": 114, "header": "tr|A0AAA9SF12-1|A0AAA9SF12_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SF12-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF12/entry#A0AAA9SF12-1", "sequence": { "sequence": "MSGGKYVDSEGCLDKAPSSLPLPLPTTSRRSGSAWVWKPSFPKRSRRRSATGQGSGSDLRVGLRNCAGTSLHCSHPGTGQHLQAQQQGYGRGNEREASVRRAHQGDRSGQPRPQ", "length": 114, "header": "tr|A0AAA9SF12-1|A0AAA9SF12_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SF12-1" }, "locus": { "chromosome": "4", "start_pos": 51901334, "end_pos": 51899718, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082424.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082424.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF34-1", "uniprot_ac": "A0AAA9SF34", "uniprot_id": "A0AAA9SF34_BOVIN", "mass": { "chemical_mass": 15766.0, "monoisotopic_mass": 15766.0 }, "refseq": { "ac": "NP_001422913", "name": "taurine up-regulated 1 (non-protein coding)", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422913" }, "gene_names": [ { "name": "TUG1", "type": "recommended", "evidence": [ { "id": "A0AAA9SF34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34" } ] }, { "name": "TUG1", "type": "synonym", "evidence": [ { "id": "NP_001422913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422913" } ] } ], "protein_names": [ { "name": "Taurine up-regulated 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SF34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34/entry#names_and_taxonomy" } ] }, { "name": "taurine up-regulated 1 (non-protein coding)", "type": "synonym", "evidence": [ { "id": "NP_001422913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422913" } ] }, { "name": "taurine upregulated gene 1", "type": "synonym", "evidence": [ { "id": "NP_001422913", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422913" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34", "locus": { "chromosome": "17", "start_pos": 69861973, "end_pos": 69861521, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069589", "url": "https://www.ensembl.org/id/ENSBTAG00000069589" } ] } } ], "crossref": [ { "id": "A0AAA9SF34", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SF34", "database": "AlphaFoldDB", "categories": [] }, { "id": "100848149", "url": "https://www.ncbi.nlm.nih.gov/gene/100848149", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "NP_001422913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422913", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SF34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARPPPLPGLVGRRSGRAVDRAIGWRLFLLLWHPALGAQARPPRRAPGGRWRSRRVFLLVRRTRAAAYAFAIRRGVVRVVGGGGQLLRPAPGEAAAAGFGAAGEAGVAGAGLEAWRHPSGPARTQLGGQEGAGGWLVVGFLLCLFLLMPP", "length": 150, "header": "tr|A0AAA9SF34-1|A0AAA9SF34_BOVIN Isoform 1 of Taurine up-regulated 1 OS=Bos taurus OX=9913 GN=TUG1 PE=4 SV=2 CANONICAL=A0AAA9SF34-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34/entry#A0AAA9SF34-1", "sequence": { "sequence": "MARPPPLPGLVGRRSGRAVDRAIGWRLFLLLWHPALGAQARPPRRAPGGRWRSRRVFLLVRRTRAAAYAFAIRRGVVRVVGGGGQLLRPAPGEAAAAGFGAAGEAGVAGAGLEAWRHPSGPARTQLGGQEGAGGWLVVGFLLCLFLLMPP", "length": 150, "header": "tr|A0AAA9SF34-1|A0AAA9SF34_BOVIN Isoform 1 of Taurine up-regulated 1 OS=Bos taurus OX=9913 GN=TUG1 PE=4 SV=2 CANONICAL=A0AAA9SF34-1" }, "locus": { "chromosome": "17", "start_pos": 69861970, "end_pos": 69861521, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099970.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099970.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084776.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084776.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF39-1", "uniprot_ac": "A0AAA9SF39", "uniprot_id": "A0AAA9SF39_BOVIN", "mass": { "chemical_mass": 11314.0, "monoisotopic_mass": 11314.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100297192", "type": "recommended", "evidence": [ { "id": "A0AAA9SF39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39" } ] } ], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SF39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100297192", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39", "locus": {} } ], "crossref": [ { "id": "cd07699", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07699", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SF39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GQPKSPPSVTLFPPSTEELNGNKATLVCLISDFYPGSVTVVWKADGSTITRNVETTRASKQSNSKYAASSYLSLTSSDWKSKGSYSCEVTHEGSTVTKTVKPSECS", "length": 106, "header": "tr|A0AAA9SF39-1|A0AAA9SF39_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC100297192 PE=1 SV=1 CANONICAL=A0AAA9SF39-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39/entry#A0AAA9SF39-1", "sequence": { "sequence": "GQPKSPPSVTLFPPSTEELNGNKATLVCLISDFYPGSVTVVWKADGSTITRNVETTRASKQSNSKYAASSYLSLTSSDWKSKGSYSCEVTHEGSTVTKTVKPSECS", "length": 106, "header": "tr|A0AAA9SF39-1|A0AAA9SF39_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC100297192 PE=1 SV=1 CANONICAL=A0AAA9SF39-1" }, "locus": { "chromosome": "17", "start_pos": 71137607, "end_pos": 71137290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149690.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149690.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104972.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104972.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SF39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF39" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 101, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF42-1", "uniprot_ac": "A0AAA9SF42", "uniprot_id": "A0AAA9SF42_BOVIN", "mass": { "chemical_mass": 36410.0, "monoisotopic_mass": 36410.0 }, "refseq": { "ac": "XP_059749135", "name": "protein phosphatase 1 regulatory subunit 42 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749135" }, "gene_names": [ { "name": "PPP1R42", "type": "recommended", "evidence": [ { "id": "A0AAA9SF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ] }, { "name": "LRRC67", "type": "synonym", "evidence": [ { "id": "XP_059749135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749135" } ] }, { "name": "PPP1R42", "type": "synonym", "evidence": [ { "id": "XP_059749135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749135" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 42", "type": "recommended", "evidence": [ { "id": "A0AAA9SF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42/entry#names_and_taxonomy" } ] }, { "name": "Leucine-rich repeat-containing protein 67", "type": "synonym", "evidence": [ { "id": "A0AAA9SF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase 1 regulatory subunit 42 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_059749135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749135" } ] } ], "function": [ { "annotation": "Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM87#function" }, { "database": "UniProtKB", "id": "ARBA00053544", "url": "https://www.uniprot.org/uniprotkb/ARBA00053544#function" }, { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42", "locus": { "chromosome": "14", "start_pos": 31135383, "end_pos": 31180398, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011205", "url": "https://www.ensembl.org/id/ENSBTAG00000011205" } ] } } ], "crossref": [ { "id": "A0AAA9SF42", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SF42", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506058", "url": "https://www.ncbi.nlm.nih.gov/gene/506058", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46652:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46652:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059749135", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749135", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM87", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRLTLDLIAKNSNLKPRKEENVLQYLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNRISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLEGLRELHVESQRLPLGEKLVFDPRTLHSLAKSLSILNISNNNIDDIRDLEILENLNQLIAADNQLLHVKDLEFLLNKLMKLWKMDLNRNPVCLKPKYRDRLILVSKSLEFLDGKEIKNMERQFLMNWKASKDAKKTSKKKNSKNEDTHNSCNSNFETMHHIVPVYYPKVGKPKLVFFSDIQRFLANGNAAPESSQEELSL", "length": 315, "header": "tr|A0AAA9SF42-1|A0AAA9SF42_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 42 OS=Bos taurus OX=9913 GN=PPP1R42 PE=4 SV=1 CANONICAL=A0AAA9SF42-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42/entry#A0AAA9SF42-1", "sequence": { "sequence": "MVRLTLDLIAKNSNLKPRKEENVLQYLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNRISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLEGLRELHVESQRLPLGEKLVFDPRTLHSLAKSLSILNISNNNIDDIRDLEILENLNQLIAADNQLLHVKDLEFLLNKLMKLWKMDLNRNPVCLKPKYRDRLILVSKSLEFLDGKEIKNMERQFLMNWKASKDAKKTSKKKNSKNEDTHNSCNSNFETMHHIVPVYYPKVGKPKLVFFSDIQRFLANGNAAPESSQEELSL", "length": 315, "header": "tr|A0AAA9SF42-1|A0AAA9SF42_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 42 OS=Bos taurus OX=9913 GN=PPP1R42 PE=4 SV=1 CANONICAL=A0AAA9SF42-1" }, "locus": { "chromosome": "14", "start_pos": 31168810, "end_pos": 31135842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130457.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130457.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081059.1" } ] } }, { "isoform_ac": "A0AAF6DM87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42/entry#A0AAF6DM87-1", "sequence": { "sequence": "MVRLTLDLIAKNSNLKPRKEENVLQYLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNRISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLEGLRELHVESQRLPLGEKLVFDPRTLHSLAKSLSILNISNNNIDDIRDLEILENLNQLIAADNQLLHVKDLEFLLNKLMKLWKMDLNRNPVCLKPKYRDRLILVSKSLEFLDGKEIKNMERQFLMNWKASKDAKKTSKKKNSKNEDTHNSCNKLSL", "length": 271, "header": "tr|A0AAF6DM87-1|A0AAF6DM87_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 42 OS=Bos taurus OX=9913 GN=PPP1R42 PE=4 SV=2 CANONICAL=A0AAA9SF42-1" }, "locus": { "chromosome": "14", "start_pos": 31168810, "end_pos": 31135842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046974.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046974.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044218.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044218.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ], "pmid": "" }, { "name": "dynein complex binding", "id": "GO:0070840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF58-1", "uniprot_ac": "A0AAA9SF58", "uniprot_id": "A0AAA9SF58_BOVIN", "mass": { "chemical_mass": 16436.0, "monoisotopic_mass": 16436.0 }, "refseq": { "ac": "XP_024852594", "name": "keratin-associated protein 12-1-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852594" }, "gene_names": [ { "name": "LOC112448007", "type": "recommended", "evidence": [ { "id": "A0AAA9SF58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58" } ] }, { "name": "LOC112448007", "type": "synonym", "evidence": [ { "id": "XP_024852594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852594" } ] } ], "protein_names": [ { "name": "Keratin-associated protein 12-1-like", "type": "recommended", "evidence": [ { "id": "A0AAA9SF58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58/entry#names_and_taxonomy" } ] }, { "name": "keratin-associated protein 12-1-like", "type": "synonym", "evidence": [ { "id": "XP_024852594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852594" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112448007", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58", "locus": {} } ], "crossref": [ { "id": "A0AAA9SF58", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SF58", "database": "AlphaFoldDB", "categories": [] }, { "id": "112448007", "url": "https://www.ncbi.nlm.nih.gov/gene/112448007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:112448007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112448007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024852594", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852594", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SF58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T106", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T106", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T106-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T106-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCHTSFSSGCQAACVPSPCQPSCFTSSACQAACVPSPCQPSCFTSSPCQAACVPSPCQPSCFTSSPCQAACVPSPCQPSCLPVSCRPAVCVTPSCRSAVRLPVSCSPAVYVPVSFKPAVCLPVSRRPALLVAPSCQSSGCYQPSRPTLVCRPVSCSTPCCL", "length": 161, "header": "tr|A0AAA9SF58-1|A0AAA9SF58_BOVIN Isoform 1 of Keratin-associated protein 12-1-like OS=Bos taurus OX=9913 GN=LOC112448007 PE=4 SV=1 CANONICAL=A0AAA9SF58-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58/entry#A0AAA9SF58-1", "sequence": { "sequence": "MCHTSFSSGCQAACVPSPCQPSCFTSSACQAACVPSPCQPSCFTSSPCQAACVPSPCQPSCFTSSPCQAACVPSPCQPSCLPVSCRPAVCVTPSCRSAVRLPVSCSPAVYVPVSFKPAVCLPVSRRPALLVAPSCQSSGCYQPSRPTLVCRPVSCSTPCCL", "length": 161, "header": "tr|A0AAA9SF58-1|A0AAA9SF58_BOVIN Isoform 1 of Keratin-associated protein 12-1-like OS=Bos taurus OX=9913 GN=LOC112448007 PE=4 SV=1 CANONICAL=A0AAA9SF58-1" }, "locus": { "chromosome": "1", "start_pos": 144593216, "end_pos": 144592734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096977.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096977.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082467.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082467.1" } ] } }, { "isoform_ac": "A0AAA9T106-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58/entry#A0AAA9T106-1", "sequence": { "sequence": "MCHTSFSSGCQAACVPSPCQPSCFTSSACQAACVPSPCQPSCFTSSPCQPSCLPVSCSPAVYVPVSFKPAVCLPVSRRPALLVAPSCQSSGCYQPSRPTLVCRPVSCSTPCCL", "length": 113, "header": "tr|A0AAA9T106-1|A0AAA9T106_BOVIN Computationally mapped isoform of Keratin-associated protein 12-1-like OS=Bos taurus OX=9913 GN=LOC112448007 PE=4 SV=1 CANONICAL=A0AAA9SF58-1" }, "locus": { "chromosome": "1", "start_pos": 144593216, "end_pos": 144592734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089335.1" } ] } }, { "isoform_ac": "A0AAA9TMD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF58/entry#A0AAA9TMD4-1", "sequence": { "sequence": "MCHTSFSSGCQAACVPSPCQPSCFTSSACQAACVPSPCQPSCFTSSPCQPSCFTSSPCQAACVPSPCQPSCLPVSCRPAVCVTPSCRSAVRLPVSCSPAVYVPVSFKPAVCLPVSRRPALLVAPSCQSSGCYQPSRPTLVCRPVSCSTPCCL", "length": 152, "header": "tr|A0AAA9TMD4-1|A0AAA9TMD4_BOVIN Computationally mapped isoform of Keratin-associated protein 12-1-like OS=Bos taurus OX=9913 GN=LOC112448007 PE=4 SV=1 CANONICAL=A0AAA9SF58-1" }, "locus": { "chromosome": "1", "start_pos": 144593216, "end_pos": 144592734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107005.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107005.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098147.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 92, "start_aa": "Thr", "end_pos": 92, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr92", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:112448007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112448007", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 92 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFA6-1", "uniprot_ac": "A0AAA9SFA6", "uniprot_id": "A0AAA9SFA6_BOVIN", "mass": { "chemical_mass": 10560.0, "monoisotopic_mass": 10560.0 }, "refseq": {}, "gene_names": [ { "name": "PRLH", "type": "recommended", "evidence": [ { "id": "A0AAA9SFA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6" } ] } ], "protein_names": [ { "name": "Prolactin releasing hormone", "type": "synonym", "evidence": [ { "id": "A0AAA9SFA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRLH", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6", "locus": { "chromosome": "3", "start_pos": 117015067, "end_pos": 117011430, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059135", "url": "https://www.ensembl.org/id/ENSBTAG00000059135" } ] } } ], "crossref": [ { "id": "A0AAA9SFA6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RARQHSM", "url": "https://omabrowser.org/oma/group/RARQHSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR17206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17206:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17206:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15172", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15172", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAVGAWLLCLLLLGLALQGAASRAHQHSMEIRTPDINPAWYAGRGIRPVGRFGRRRAALGDGPRPGPRRVPACFRLEGGAEPSRALPGRLTAQLVQE", "length": 98, "header": "tr|A0AAA9SFA6-1|A0AAA9SFA6_BOVIN Isoform 1 of Prolactin releasing hormone OS=Bos taurus OX=9913 GN=PRLH PE=4 SV=1 CANONICAL=A0AAA9SFA6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6/entry#A0AAA9SFA6-1", "sequence": { "sequence": "MKAVGAWLLCLLLLGLALQGAASRAHQHSMEIRTPDINPAWYAGRGIRPVGRFGRRRAALGDGPRPGPRRVPACFRLEGGAEPSRALPGRLTAQLVQE", "length": 98, "header": "tr|A0AAA9SFA6-1|A0AAA9SFA6_BOVIN Isoform 1 of Prolactin releasing hormone OS=Bos taurus OX=9913 GN=PRLH PE=4 SV=1 CANONICAL=A0AAA9SFA6-1" }, "locus": { "chromosome": "3", "start_pos": 117014307, "end_pos": 117013542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115822.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115822.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084047.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084047.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3UWC3-1", "protein_name": "Prolactin releasing hormone", "gene_name": "Prlh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPRTWLLCLLLLGLVLPGASSRAHQHSMETRTPDINPAWYTGRGIRPVGRFGRRRAALRDVTGPGLRCRLSCFPLDGSAKFSHSS", "length": 86 }, "evidence": [ { "id": "A0AAA9SFA6", "url": "https://omabrowser.org/oma/group/A0AAA9SFA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P81277-1", "protein_name": "Prolactin-releasing peptide", "gene_name": "PRLH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVLRAWLLCLLMLGLALRGAASRTHRHSMEIRTPDINPAWYASRGIRPVGRFGRRRATLGDVPKPGLRPRLTCFPLEGGAMSSQDG", "length": 87 }, "evidence": [ { "id": "A0AAA9SFA6", "url": "https://omabrowser.org/oma/group/A0AAA9SFA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFB1-1", "uniprot_ac": "A0AAA9SFB1", "uniprot_id": "A0AAA9SFB1_BOVIN", "mass": { "chemical_mass": 43866.0, "monoisotopic_mass": 43866.0 }, "refseq": {}, "gene_names": [ { "name": "EEF2KMT", "type": "recommended", "evidence": [ { "id": "A0AAA9SFB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1" } ] } ], "protein_names": [ { "name": "Eukaryotic elongation factor 2 lysine methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SFB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EEF2KMT", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFB1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "531984", "url": "https://www.ncbi.nlm.nih.gov/gene/531984", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14614:SF130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14614:SF130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14904", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14904", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8G2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8G2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8G2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZCX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZCX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VGWGAPRVRGERGSGVTHPPSLPRDGLCYLAGPSGTSGPPGSPGPRGLAARGQALHRCAPGPSLRALGPTLRSALNSLFPWTLAALHRLCRQNWRNSLEEKLRDSSGSELLLDILQKTVKHPLCVKHPPSVKYSRSFLSELIRKHEAVHTEPLDELYQALAEVLTAEDPTHCHRSYLLPSGDSVTLCESTAIVSHGTTGLVTWNAALYLAEWAVENPAVFAHRMVLELGSGAGLTGLAICKTCRPRAYIFSDCHSHVLEQLRGNVLLNGFSLEPSIDTWAQHPGPHTPEAERPWVTVARLDWDTVTAPQLAAFQPDVVLAADVLYCPETVLSLVGVLRKLSTCRKDQRAPDAYIAFTVRNPETCQLFTTELGEPRAPGQAAVCERPAGSLHWPHTGLQGAQKPGK", "length": 405, "header": "tr|A0AAA9SFB1-1|A0AAA9SFB1_BOVIN Isoform 1 of Eukaryotic elongation factor 2 lysine methyltransferase OS=Bos taurus OX=9913 GN=EEF2KMT PE=3 SV=1 CANONICAL=A0AAA9SFB1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1/entry#A0AAA9SFB1-1", "sequence": { "sequence": "VGWGAPRVRGERGSGVTHPPSLPRDGLCYLAGPSGTSGPPGSPGPRGLAARGQALHRCAPGPSLRALGPTLRSALNSLFPWTLAALHRLCRQNWRNSLEEKLRDSSGSELLLDILQKTVKHPLCVKHPPSVKYSRSFLSELIRKHEAVHTEPLDELYQALAEVLTAEDPTHCHRSYLLPSGDSVTLCESTAIVSHGTTGLVTWNAALYLAEWAVENPAVFAHRMVLELGSGAGLTGLAICKTCRPRAYIFSDCHSHVLEQLRGNVLLNGFSLEPSIDTWAQHPGPHTPEAERPWVTVARLDWDTVTAPQLAAFQPDVVLAADVLYCPETVLSLVGVLRKLSTCRKDQRAPDAYIAFTVRNPETCQLFTTELGEPRAPGQAAVCERPAGSLHWPHTGLQGAQKPGK", "length": 405, "header": "tr|A0AAA9SFB1-1|A0AAA9SFB1_BOVIN Isoform 1 of Eukaryotic elongation factor 2 lysine methyltransferase OS=Bos taurus OX=9913 GN=EEF2KMT PE=3 SV=1 CANONICAL=A0AAA9SFB1-1" }, "locus": { "chromosome": "25", "start_pos": 4112198, "end_pos": 4103482, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082543.1" } ] } }, { "isoform_ac": "A0AAA9T8G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1/entry#A0AAA9T8G2-1", "sequence": { "sequence": "MAPEERADAARLLRGFERRFLAARALRSFPWQSLEEKLRDSSGSELLLDILQKTVKHPLCVKHPPSVKYSRSFLSELIRKHEAVHTEPLDELYQALAEVLTAEDPTHCHRSYLLPSGDSVTLCESTAIVSHGTTGLVTWNAALYLAEWAVENPAVFAHRMVLELGSGAGLTGLAICKTCRPRAYIFSDCHSHVLEQLRGNVLLNGFSLEPSIDTWAQHPGPHTPEAERPWVTVARLDWDTVTAPQLAAFQPDVVLAAGTAWLSAGTQQWTLPGGKNGGTWVAWASRVTAQHGACLLGALRPQPPRLRQRPCVLPRKWSLLWRNQLCPARRAMSRTGPRAPDQRDQS", "length": 346, "header": "tr|A0AAA9T8G2-1|A0AAA9T8G2_BOVIN Computationally mapped isoform of Eukaryotic elongation factor 2 lysine methyltransferase OS=Bos taurus OX=9913 GN=EEF2KMT PE=3 SV=1 CANONICAL=A0AAA9SFB1-1" }, "locus": { "chromosome": "25", "start_pos": 4112317, "end_pos": 4104618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132316.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132316.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093094.1" } ] } }, { "isoform_ac": "A0AAF6ZCX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1/entry#A0AAF6ZCX3-1", "sequence": { "sequence": "APPPELCAPPPRAPAALDPAPSPTPAPCARLWPPRITALLPPSLLGNAAASPHHGAGGESGCRAPAAGFRAPLLGGARPALLSLAGGRQGARKSLEEKLRDSSGSELLLDILQKTVKHPLCVKHPPSVKYSRSFLSELIRKHEAVHTEPLDELYQALAEVLTAEDPTHCHRSYLLPSGDSVTLCESTAIVSHGTTGLVTWNAALYLAEWAVENPAVFAHRMVLELGSGAGLTGLAICKTCRPRAYIFSDCHSHVLEQLRGNVLLNGFSLEPSIDTWAQHPGPHTPEAERPWVTVARLDWDTVTAPQLAAFQPDVVLAADVLYCPETVLSLVGVLRKLSTCRKDQRAPDAYIAFTVRNPETCQLFTTELGQAGIPWEEVPCHDQKLFPYEEHSEMAILKLTL", "length": 401, "header": "tr|A0AAF6ZCX3-1|A0AAF6ZCX3_BOVIN Computationally mapped isoform of Eukaryotic elongation factor 2 lysine methyltransferase OS=Bos taurus OX=9913 GN=EEF2KMT PE=3 SV=1 CANONICAL=A0AAA9SFB1-1" }, "locus": { "chromosome": "25", "start_pos": 4112477, "end_pos": 4101599, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037485.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037485.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037316.6", "url": "https://www.ensembl.org/id/ENSBTAP00000037316.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFB1" }, { "id": "PF14904", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14904" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM86 N-terminal", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 163, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFC8-1", "uniprot_ac": "A0AAA9SFC8", "uniprot_id": "A0AAA9SFC8_BOVIN", "mass": { "chemical_mass": 38125.0, "monoisotopic_mass": 38125.0 }, "refseq": {}, "gene_names": [ { "name": "TECTB", "type": "recommended", "evidence": [ { "id": "A0AAA9SFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ] } ], "protein_names": [ { "name": "Beta-tectorin", "type": "recommended", "evidence": [ { "id": "A0AAA9SFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.", "evidence": [ { "database": "UniProtKB", "id": "E1BI14", "url": "https://www.uniprot.org/uniprotkb/E1BI14#function" }, { "database": "UniProtKB", "id": "ARBA00058814", "url": "https://www.uniprot.org/uniprotkb/ARBA00058814#function" }, { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TECTB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8", "locus": { "chromosome": "26", "start_pos": 32835691, "end_pos": 32816060, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006689", "url": "https://www.ensembl.org/id/ENSBTAG00000006689" } ] } } ], "crossref": [ { "id": "A0AAA9SFC8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006689", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006689", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BI14", "url": "https://www.orthodb.org/?gene=E1BI14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00100", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00100", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI14", "url": "https://www.uniprot.org/uniprotkb/E1BI14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI14-1", "url": "https://www.uniprot.org/uniprotkb/E1BI14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVMRAFVLLAVFAEASARSCTPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEAGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDSTVIVKNQPVNYSFSCTYHSTYLVDQAAFDQSPYAKFSPLFRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFILETSEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGKDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGSSGLYSFSAHLNEVEGAGGSGLSPTSP", "length": 342, "header": "tr|A0AAA9SFC8-1|A0AAA9SFC8_BOVIN Isoform 1 of Beta-tectorin OS=Bos taurus OX=9913 GN=TECTB PE=4 SV=1 CANONICAL=A0AAA9SFC8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8/entry#A0AAA9SFC8-1", "sequence": { "sequence": "MVMRAFVLLAVFAEASARSCTPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEAGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDSTVIVKNQPVNYSFSCTYHSTYLVDQAAFDQSPYAKFSPLFRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFILETSEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGKDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGSSGLYSFSAHLNEVEGAGGSGLSPTSP", "length": 342, "header": "tr|A0AAA9SFC8-1|A0AAA9SFC8_BOVIN Isoform 1 of Beta-tectorin OS=Bos taurus OX=9913 GN=TECTB PE=4 SV=1 CANONICAL=A0AAA9SFC8-1" }, "locus": { "chromosome": "26", "start_pos": 32832928, "end_pos": 32816332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084879.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084879.1" } ] } }, { "isoform_ac": "E1BI14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8/entry#E1BI14-1", "sequence": { "sequence": "MVMRAFVLLAVFAEASARSCTPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEAGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDSTVIVKNQPVNYSFSCTYHSTYLVDQAAFDQSPYAKFSPLFRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFILETSEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGKDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGSSGLYSFSDVLYHLIVMLGVCAVL", "length": 339, "header": "tr|E1BI14-1|A0AAA9SFC8_BOVIN Computationally mapped isoform of Beta-tectorin OS=Bos taurus OX=9913 GN=TECTB PE=4 SV=2 CANONICAL=A0AAA9SFC8-1" }, "locus": { "chromosome": "26", "start_pos": 32833929, "end_pos": 32816332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046061.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046061.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043389.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043389.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 217, "start_aa": "Thr", "end_pos": 217, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr217", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFC8" }, { "id": "PS51034", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51034" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZP", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 293, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 217 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 116, "end_pos": 118 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFD3-1", "uniprot_ac": "A0AAA9SFD3", "uniprot_id": "A0AAA9SFD3_BOVIN", "mass": { "chemical_mass": 167460.0, "monoisotopic_mass": 167460.0 }, "refseq": { "ac": "XP_010812165", "name": "golgin subfamily A member 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812165" }, "gene_names": [ { "name": "GOLGA3", "type": "recommended", "evidence": [ { "id": "A0AAA9SFD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3" } ] }, { "name": "GOLGA3", "type": "synonym", "evidence": [ { "id": "XP_010812165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812165" } ] } ], "protein_names": [ { "name": "Golgin A3", "type": "synonym", "evidence": [ { "id": "A0AAA9SFD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3/entry#names_and_taxonomy" } ] }, { "name": "golgin subfamily A member 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010812165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812165" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLGA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3", "locus": { "chromosome": "17", "start_pos": 44468139, "end_pos": 44423371, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009755", "url": "https://www.ensembl.org/id/ENSBTAG00000009755" } ] } } ], "crossref": [ { "id": "533600", "url": "https://www.ncbi.nlm.nih.gov/gene/533600", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QDDQHAQ", "url": "https://omabrowser.org/oma/group/QDDQHAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR18902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18902:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18902:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_010812165", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812165", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSAAAMQEGLVEDRSSSGSSAQPEGPPKPPGSLAPLDQWDEAQCASAKVNRTSDEGRQGDTCLNGPTPQFPEPPSPSGPDASPGVAGFHDNLRKSQGTSAEGIVRKEALQSLRLSLPMQETQLCSTEASLPLEKEEQVRLQARKRLEEQLKQYRVKRQQERSSQPVTKTRLFSTLDPELMLNPETLPRASAVAMTKEYSFLRTSVPRGPKVGSLGLLAHPKEKKSSKSSKIRSLADYRTEDSDVRNSGGNVPAPDSTRGSLKQNRGSGTSVVSEVSLCPEADDRLENASLTGDNVSEADGTESDSSSYSSVSARGTPGIPANMGGTREAPYMVSGREIAVGALGQFPSISDVLQAAAAEHQEQRQEVNGETRSRTNSICSSVSLESSVAETHDEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALHTRLQAQLEHSHSSQQRQDSLSSEVDTLKQSCWDLEQAMTDLQNMLEAKNASLASSNSDLQVAEEQYQRLMAKVEEMQRSILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEIASLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMSQAGLLEHLKLENVSLSHQLTETQQRSIKEKERIAAQLQGIEADMLDQEAAFVQIQEAKTMVEEDLQRRLEEFEDEKEQLQKMVASAAVLEQQLEQVKLTLHQRDQQLEALQQEHLDLLKQFTSTQETLQTREQSLGDLQVRYDELQARLDELQGEAASREDAIQALQNEKIVLEVALQAAHSSREEFDRGAKRLEEGAQDTSDTLEQLRQELAIKSSQVEHLQQEAGALKKQTQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATKKRLDSEVKELRQELMKLQGEKRSVEVEHSRLQKEMSQIQQQVVDLEGHLQSAQRERDEMETQLQSLQFDKEQMVAVTEANEVLKKQIEELQQEATKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAAEAELSQLRAQAAAGGSDLTLHERVQVLEAELQAVGHSKMMLERELQEVISLTGQELEEQREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQAALQKEKVMVHSLEEQVAAAKAEAGHNRRHFKAATLELSEVKKELQAKEQEVQRLQAEADGLQIQEGKHSQEIAEFQAELAEARTQLQLLQKQLDEQLSKEPIGNQEMENLKWEVDQKEREIQSLKQQLDLTEHQSKQELDGIQQSLQNIKSELEMVREDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSSPVTPVKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEAHAVTVHESLSSWTQGDPASPSPPGDHANPRGDTERHGQGRASQEGLGTVTTEHPHPECL", "length": 1496, "header": "tr|A0AAA9SFD3-1|A0AAA9SFD3_BOVIN Isoform 1 of Golgin A3 OS=Bos taurus OX=9913 GN=GOLGA3 PE=4 SV=1 CANONICAL=A0AAA9SFD3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3/entry#A0AAA9SFD3-1", "sequence": { "sequence": "MDSAAAMQEGLVEDRSSSGSSAQPEGPPKPPGSLAPLDQWDEAQCASAKVNRTSDEGRQGDTCLNGPTPQFPEPPSPSGPDASPGVAGFHDNLRKSQGTSAEGIVRKEALQSLRLSLPMQETQLCSTEASLPLEKEEQVRLQARKRLEEQLKQYRVKRQQERSSQPVTKTRLFSTLDPELMLNPETLPRASAVAMTKEYSFLRTSVPRGPKVGSLGLLAHPKEKKSSKSSKIRSLADYRTEDSDVRNSGGNVPAPDSTRGSLKQNRGSGTSVVSEVSLCPEADDRLENASLTGDNVSEADGTESDSSSYSSVSARGTPGIPANMGGTREAPYMVSGREIAVGALGQFPSISDVLQAAAAEHQEQRQEVNGETRSRTNSICSSVSLESSVAETHDEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALHTRLQAQLEHSHSSQQRQDSLSSEVDTLKQSCWDLEQAMTDLQNMLEAKNASLASSNSDLQVAEEQYQRLMAKVEEMQRSILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEIASLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMSQAGLLEHLKLENVSLSHQLTETQQRSIKEKERIAAQLQGIEADMLDQEAAFVQIQEAKTMVEEDLQRRLEEFEDEKEQLQKMVASAAVLEQQLEQVKLTLHQRDQQLEALQQEHLDLLKQFTSTQETLQTREQSLGDLQVRYDELQARLDELQGEAASREDAIQALQNEKIVLEVALQAAHSSREEFDRGAKRLEEGAQDTSDTLEQLRQELAIKSSQVEHLQQEAGALKKQTQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATKKRLDSEVKELRQELMKLQGEKRSVEVEHSRLQKEMSQIQQQVVDLEGHLQSAQRERDEMETQLQSLQFDKEQMVAVTEANEVLKKQIEELQQEATKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAAEAELSQLRAQAAAGGSDLTLHERVQVLEAELQAVGHSKMMLERELQEVISLTGQELEEQREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQAALQKEKVMVHSLEEQVAAAKAEAGHNRRHFKAATLELSEVKKELQAKEQEVQRLQAEADGLQIQEGKHSQEIAEFQAELAEARTQLQLLQKQLDEQLSKEPIGNQEMENLKWEVDQKEREIQSLKQQLDLTEHQSKQELDGIQQSLQNIKSELEMVREDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSSPVTPVKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEAHAVTVHESLSSWTQGDPASPSPPGDHANPRGDTERHGQGRASQEGLGTVTTEHPHPECL", "length": 1496, "header": "tr|A0AAA9SFD3-1|A0AAA9SFD3_BOVIN Isoform 1 of Golgin A3 OS=Bos taurus OX=9913 GN=GOLGA3 PE=4 SV=1 CANONICAL=A0AAA9SFD3-1" }, "locus": { "chromosome": "17", "start_pos": 44467135, "end_pos": 44430048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097373.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097373.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082572.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082572.1" } ] } }, { "isoform_ac": "A0AAA9SIN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3/entry#A0AAA9SIN3-1", "sequence": { "sequence": "MDSAAAMQEGLVEDRSSSGSSAQPEGPPKPPGSLAPLDQWDEAQCSTEASLPLEKEEQVRLQARKRLEEQLKQYRVKRQQERVSLPLSNQLMEKQQSVSHNSRICCLFLF", "length": 110, "header": "tr|A0AAA9SIN3-1|A0AAA9SIN3_BOVIN Computationally mapped isoform of Golgin A3 OS=Bos taurus OX=9913 GN=GOLGA3 PE=4 SV=1 CANONICAL=A0AAA9SFD3-1" }, "locus": { "chromosome": "17", "start_pos": 44435260, "end_pos": 44430048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091948.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091948.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083623.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083623.1" } ] } }, { "isoform_ac": "A0AAA9SQ12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3/entry#A0AAA9SQ12-1", "sequence": { "sequence": "MDSAAAMQEGLVEDRSSSGSSAQPEGPPKPPGSLAPLDQWDEAQCASAKVNRTSDEGRQGDTCLNGPTPQFPEPPSPSGPDASPGSTEASLPLEKEEQVRLQARKRLEEQLKQYRVKRQQERSSQPVTKTRLFSTLDPELMLNPETLPRASAVAMTKEYSFLRTSVPRGPKVGSLGLLAHPKEKKSSKSSKIRSLADYRTEDSDVRNSGGNVPAPDSTRGSLKQNRGSGTSVVSEVSLCPEADDRLENASLTGDNVSEADGTESDSSSYSSVSARGTPGIPANMGGTREAPYMVSGREIAVGALGQFPSISDVLQAAAAEHQEQRQEVNGETRSRTNSICSSVSLESSVAETHDEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALHTRLQAQLEHSHSSQQRQDSLSSEVDTLKQSCWDLEQAMTDLQNMLEAKNASLASSNSDLQVAEEQYQRLMAKVEEMQRSILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEIASLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMSQAGLLEHLKLENVSLSHQLTETQQRSIKEKERIAAQLQGIEADMLDQEAAFVQIQEAKTMVEEDLQRRLEEFEDEKEQLQKMVASAAVLEQQLEQVKLTLHQRDQQLEALQQEHLDLLKQFTSTQETLQTREQSLGDLQVRYDELQARLDELQGEAASREDAIQALQNEKIVLEVALQAAHSSREEFDRGAKRLEEGAQDTSDTLEQLRQELAIKSSQVEHLQQEAGALKKQTQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATKKRLDSEVKELRQELMKLQGEKRSVEVEHSRLQKEMSQIQQQVVDLEGHLQSAQRERDEMETQLQSLQFDKEQMVAVTEANEVLKKQIEELQQEATKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAAEAELSQLRAQAAAGGSDLTLHERVQVLEAELQAVGHSKMMLERELQEVISLTGQELEEQREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQAALQKEKVMVHSLEEQVAAAKAEAGHNRRHFKAATLELSEVKKELQAKEQEVQRLQAEADGLQIQEGKHSQEIAEFQAELAEARTQLQLLQKQLDEQLSKEPIGNQEMENLKWEVDQKEREIQSLKQQLDLTEHQSKQELDGIQQSLQNIKSELEMVREDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKQEMDSLQRQMEAHAVTVHESLSSWTQGDPASPSPPGDHANPRGDTERHGQGRASQEGLGTVTTEHPHPECL", "length": 1391, "header": "tr|A0AAA9SQ12-1|A0AAA9SQ12_BOVIN Computationally mapped isoform of Golgin A3 OS=Bos taurus OX=9913 GN=GOLGA3 PE=4 SV=1 CANONICAL=A0AAA9SFD3-1" }, "locus": { "chromosome": "17", "start_pos": 44467135, "end_pos": 44430048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087461.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087461.1" } ] } }, { "isoform_ac": "A0AAA9TW43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3/entry#A0AAA9TW43-1", "sequence": { "sequence": "MDSAAAMQEGLVEDRSSSGSSAQPEGPPKPPGSLAPLDQWDEAQCASAKVNRTSDEGRQGDTCLNGPTPQFPEPPSPSGPDASPGVAGFHDNLRKSQGTSAEGIVRKEALQSLRLSLPMQETQLCSTEASLPLEKEEQVRLQARKRLEEQLKQYRVKRQQERVSLPLSNQLMEKQQSVSHNSRICCLFLF", "length": 190, "header": "tr|A0AAA9TW43-1|A0AAA9TW43_BOVIN Computationally mapped isoform of Golgin A3 OS=Bos taurus OX=9913 GN=GOLGA3 PE=4 SV=1 CANONICAL=A0AAA9SFD3-1" }, "locus": { "chromosome": "17", "start_pos": 44435260, "end_pos": 44430048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109232.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109232.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101402.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1385, "start_aa": "Thr", "end_pos": 1385, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1385", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 68, "start_aa": "Thr", "end_pos": 68, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr68", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZGC2-1", "protein_name": "Golgin A3", "gene_name": "GOLGA3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESSSVQQDVLLDNRSSSGAPGTSQEHGDCNANSALPATGDEVNTSSVNLSEVPNEEGSLELNSKADACQNGPELLFPDSPISFDPTSSPQGQESSPGVPGFHDSLRKSQGTSAEGVALRKEALQSLKLSLPMQETELCSVESSLPLENEEQIRLQARRRLEEQLRQYRVKRHQERSNQSTSKSRPSSTLDPELMLNPEILPRASTVAMTKEYSFLRTSVPRGPKLGSLGLPASSKERKSSKSSKSSKIRSLADYRTEDSGSGSSAGNLMATDLPGGTLKQSRSGPASVVSEISLPFDTDDRIENSSLAGDSISEIDGSEAGMRLDGNESDSSTYSSVSGKGLCNNLPNSEGKERIPYTINGQKIHPDAIGQFPSISEVLQAAAVEHQAQEQEFNGEIRSRRDSISSSVSMESSVAGTHDEMLQVLKEKMRLEGQLEALSAEANQALKEKAELQAQLAALNMKLQAQVEHSQSSQQKQESLSSEVATLKQSCWDLERAMADLQNTLEAKNASLASSNNDLQLAEEQYQRLMLKVEDMQKSVLTRDSTVHDLRQQLASLQSQLQKVQLERTTLTNKLKASETEITSLQNVRQWYQQQLVLAQEARVRLQSEMANIQAGQMTQAGVLEHLKLENVALSQQLTETQHRSIKEKERIAAQLQNIEADMLDQEAAFMQIQEAKTMVEEDLQRKLEEFEDEKEQLQKMADSAATLEQELDQVKLTLHQRDLQLESLQQEHLDLMKQFTMTQEMLHTKEQTLDDLQTQYDELKARLEEFQSDATSKDDMIQYLQNEKIVLEVALQTAKASQDQLDEGTKRLGEDTEVTSEILEQLRQEMAIRSSQVENLQQENGSLKKQVQKVKEQFLQQKVMVEAYRRDASSKDQLISELKATKKRLDSEMKELKRELLQIQVEKQSLETEHSKLQKEVTEVHQQMVEIENHLQSVQKERDEMETRLQSLQFDKEQMASLAEANQTLKLQVEQMQEEAKKAITEQKQKMKRLGSDLTSAQKEMKAKHKAYENAVSILSRRLQESLTAKESAEAELSKLKAQITDGGSNQIAQERIQALETELQAVRSSKLMLEKELQEVISLTSQELEEYREKVLELEDELQESRGFRRKIKRLEEINKKLALELEHERGKLTGLSQSNAALREHNNVLETALAKREADLVQLNLQVQAVLKRKEEEDQQMQQLIQALQASLEKEKSKVKDLKEQVAAAKADAAHNRRHYRAAALELNEVKKELHAKELLVQALQAEVDKLQVEDEKHSQEVSQFQQELAEARSQLQLLQKKLDDKLSEQPLVSQEVEDLKWEVEQKEREIGTLKQQLDMSEQRSHKELEGMQVVLQNIKTELEVVREDLSVTQKDKFMLQAKVSELKNSMKSLLQQNQQLKMDLKHGKMKKRKGENNSSNPVTPVKIPDCPVPAALLEELLKPSTAVSKEPLKNLNSCLRQLKQEMDSLQRQMEEHTITVHESMSSWTQIEEQLMDFTSTSPATASDQQERPALVETKHNCDVSDKEALAL", "length": 1516 }, "evidence": [ { "id": "A0AAA9SFD3", "url": "https://omabrowser.org/oma/group/A0AAA9SFD3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7GW86-1", "protein_name": "Golgin subfamily A member 3 isoform X1", "gene_name": "Golga3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLFRVFLVWAALTMDGVPVKQDGFWEDKSSNDISSCPEASPETLGSLALPPDQPNEVQSVSIEVNNSIFREGGSPDRSSQEALCQNGQFPDHPLSLDPTASPVGPDASAGVDGFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEEQLIQYRVKRHRERSSQPATKMKLFSTLDPELMLNPENLPRASTVAVTKEYSFLRTSVPRGPKVGSLGLLAQSKEKKSSKSSKIRSLADYRTEDSSDSGGLGSTGDAVGGSLKQSRSSTSVVSEVSPSSETDNRVESASLAGDSVSEADGNESDSSSHSSFSTRGACGVLVNVAMPGAAYMVDGQEISVEALGQFPSIKDVLQSAAAQHQDQNQEVNGEVQSRRDSICSSVSMESSLAETQDEMLQVLKEKMRLEGQLEALSLEATQALQEKAELQAQLAALSTRLQAQVEHSHSSQQKQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRNILSKDNTVHDLRQQMAALQSQLHQVQLERTTLTSKLQASQAEITSLQHARQWYQQQLALAQEARVRLQGEVAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFLQIKEAKTMVEEDLQRRLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQEHLDVIKQLTSTQEALQSKGQSLDELHSRYDELQARLEELQREADSREDTIHFLQNEKIVLEVALQSARNDKEELDRGTQHLEEDTEETSGILEQLRQELAVKSNQVEHLQQETASLRKQIQKVKEQFLQQKVMVEAYRRDATSKDQLISELKATKKRLDSEMKELRQELIKVHGEKKTVEVEHSRLQKEMSLVHQQMADLEGHLQSVQKERDEMETHLQSLQFDKEQMVALTEANETLKKQIEELQQEAKKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALATKEATDAELSQLRAQSTGGSSDPVLHEKIRALEVELQNVGQSKILLEKELQEVITMTSQELEESREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVEALQASLEKEKMKVNSMKEQMAAAKVEAGHNRRHFKAATLELSEVKKELQAKEHLVQTLQAQADELQIQEGKHSQEIAHFQTELAEARTRLQFLQKQLDEQMSQQPTGSQEMENLKWELDQKEREIQSLKQQLDLTEQHGKKELESTQQTLQTIRSELEMVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKKKEPKGESNSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHTITVHESLSSWAQAEAAPAEHAHPRGDTKPHSQNSVPREGLGQ", "length": 1501 }, "evidence": [ { "id": "A0AAA9SFD3", "url": "https://omabrowser.org/oma/group/A0AAA9SFD3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2CEB4-1", "protein_name": "Golgin subfamily A member 3", "gene_name": "golga3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MENGNNGMVSIEAKPPQHPDAQHCKNPNSNTVESLKPERSLVTEKIPNGHVKAELLPNGEAMVEGQDVGGGSTPPSATPSPGSRLSDSSPSTELDPGVVSFPDSLERSEGSVHTGDALQSLRLSIPMQETELSSTDPCVEMENEEKIRQEARRRLEEQLKQYRAQRHTERTRRSTPKSRPFSTLDPELMLHPEGLPRANTVAMTKEYSFLRTSVPRGPKLGSLGIPSSREKKSKSSRSSKIHSLADYKTPESEGSGGAVSASADSSFTSLHSTISSVSTVSEISISSEANNHSESSQLIRDNISEVDGSESGFRADGNDSDSSSYSSVSTTGTYNMLSAIVNRPKAPYTVEGREIAAEAMGHFPSLQEVLQAATEERHMEELEQDREGSVEPRSRRDSFSSSVSYGSSVMGTHDEMLQVLKEKMRLEGQLESLSSEASQALKEKTELQAQLATVNAQLKAQVEQTQAGQERQSTLKTEVTTLRSNCSALEKAMVDLQTNLEGKNASLASLGNDLEVAEEQYQRLMVKVEEMQQSLNAKDNTVSELRQQMGGLQTQLQRVQSERNALQSRLKTSQAEVDSLQQLRLWYQQQLNLAQEARVRLQGEMANMQAGQMTQFGVLENLKIENVTLSHKLTETNHRSIKEKERIAVQLQSIEADMLTQEAAIHQIQEAKTMVEEDLQHKLEEFEEEREHLLKLANTATTLERELEQVKLVLFQKDSQLESLQREHLELMKQLTTTQETLQTKEQALNQLEARYQELQVQLEELQTDASAKEETLQYLQNEKIVLEVALQAARADKSELDEGAEKLGEEVLVASDTLDQLRQEVQVKATQIEALQHENGTLKKQAQKLKEQFMQQKVMVEAYRRDASSKEQLISELKASKKRLVAEVKDLKQELLKTEGEKKSAVQEQARLQKEVERVQQQMNGLEAHLQSVQTERDQLDSQLQSLQFDQNQLAAVTEENENLRKRVEQMQNEARTAISEQKVKMKRLGTDLTSAQKEMKAKHKAYENAVGILSRRLQEALAAKETAEAELDKLKAQVADGGNSQELQAKVKSLQGELQAVSQSKAMLEKELQEVITLTSTELEEYQEKVLELEDEQLQESRNFKKRIRRLEDANKKLALELEHEKGKLSGLGKSHSALREHANILEAALAKREADLVQLNLQVQAVLKRKEEEDQQMRQLVQTLQTALEKEKIKVKDLTEQVAEAKLEAAHNRRHYRAAVLELSEIKKDLQAKEELVKALEKEATTLAAQDEKHSEEVSRFREELADAHTQLQILQKQLDDELNKQPVTNQEVEDLKWEVEQKQREMEAQKQQLEMVEQCHQREMQSQQDMLQTIKVELEMVQEELNGTRKDKFMLQAKVGELRNSMKTVLQQNNQLKQDLKNSRLRKQRMDLKGESTPVTPVKIPDCPVPASLLDELLKPSTSVNKEPLNNLHNCLKQLKQEMDSLQKQMEEHTVTVTSLASPEDELQKLGLHDSSESSNKEDKEEMLPS", "length": 1494 }, "evidence": [ { "id": "A0AAA9SFD3", "url": "https://omabrowser.org/oma/group/A0AAA9SFD3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZLD5-1", "protein_name": "Golgin A3", "gene_name": "Golga3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDGASAKQDGLWENKSSSDISSCPEASLETVGSLAQLPDQQDTAQDGSVEVNRVFKEEGSPDRSSQVPICQNGQIPDLQLSLDPTTSPVGPDASTGVDGFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEEQLMQYRVKRHRERSSQPATKMKLFSTLDPELMLNPENLPRASAVAVTKEYSFLRTSVPRGPKVGSLGLLAHSKEKKNSKSSKIRSLADYRTEDPSDSGGLGSTADAVGSSLKQSRSSTSVVSEVSPSCETDNRAESASLAGDSVSEADGNESDSSSHSSFSARGACAVLGNVGTPGAAYVVDGQEISAEALGQFPSIKDVLQAAAAQHQDQNQEANGEVQSRRDSICSSVSMESSFAEPQEELLQILKDKRRLEGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVEHSHSSQQKQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEAMQRNILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLQASQAEITSLQQARQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFVQIREAKTMVEEDLQRKLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQEHLDVIKQLTSTQEALQAKGQSLDDLQTRYDELQARLEELQREADSREDAIHFLQNEKIVLEVALHSARSDKEELDRGARRLEEDTEETSGLLEQLRQDVAVKSNQVEHLQQETATLRKQMQKVKEQFLQQKVMVEAYRRDAASKDQLINELKATKKRLDSEMKELRQELIKLHGEKKTVEVEHSRLQKDMSLVHQQMAELEGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLKKQIEELQQEAKKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALANKEATDAELNQLRAQSTGGSSDPALHEKIHALEVELQNVGQSKILLEKELQEVITMTSQELEESREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQISLEKEKTEVSSLKEQMAAARVEAGHNRRHFKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQEGKHSQEIAQFQTELAEARTQLQLLQKKLEEQRSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEHQGKKELEGTQQTLQTIKSELETVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKKKEPKGESSSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHTITVHESLSSWAQVEAAPAEHAHARGDTKVHNQNSVPGEGLGQ", "length": 1487 }, "evidence": [ { "id": "A0AAA9SFD3", "url": "https://omabrowser.org/oma/group/A0AAA9SFD3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RI72-1", "protein_name": "Golgin A3", "gene_name": "GOLGA3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGVVAMQDGPEDRSSNGPEALPKPPGSLALLDQQEEAQCTNVEVNRASDEGGSQGDTCQNGPMPQFPDPPSSVGPDASPGVAGFHDNLRKSQGTSAEGSGRKEALQSLRLSLPMQETQLCSTEASLPLEKEEQVRLQARKRLEEQLKQYRVKRQQERSSQPVTKTRLFSTLDPELMLNPETLPRASAVAMTKEYSFLRTSVPRGPKVGSLGLLAHPKEKKSSKSSKIRSLADYRTEESDAQNSGGSVPAVDSARASLKQNRSSGTSVVSEVSLCPEADDRLENASLTGDNVSEADGNESDSSSYSSVSTRGALSLLANSLGTREAPYVVSGQEVAAAALGQFPSISDVLQAAAAEHQDQRQEVNGETRSRADSICSSVSMESSVAETHDEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTRLQAQVEHSHNSQQRQDSLSSEVDTLKQSCWDLEQAMADLQNMLEAKNASLASSNSDLQVAEEQYHRLMAKVEEMQRSMLSKDNTVHDLRQQMTALQSQLRQVQLERTALSSKLQASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQQRSIKEKERIAAQLQGIEADMLDQEAAFVQIQEAKTMVEEDLQRRLEEFEDEKEQLQKMVASVATLEQQLEQVKLTLHQRDQQLEALQQEHLDLLKQFTSTQENLQAREQALGDLRVRCDELQARLDELQGEAASRDDTICVLQNEKIVLEVALQAARREELDPGSKRQEESTEETSETLERLREELAIKSSQVEHLQQEAATLKKQTQKIKEQFLQQKVMVEAYRRDAASKDQLVSELKATKKRLDAEAKELRQELIRLQGEKRSVEVEHARLQKDVTQARQQVADLEGHLQSVQRERDQMEMNLQSLQFDKEQMVALTEANEVLKKQIEELQQEATKAITEQKQKMKRLGSDLSSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAAEAELGQLRAQAASSSDDFPLHERIQALETELQTVGHSKTMLERELQEVISMTSQELEEQREKVLELEDELQEARGFRRKIKHLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQVALQKEKVTVRSLEEQVAAAKAEAGHNRRHFKAATLELSEVKKELQAKEQEVQRLQAEADGLQIQEGKHSQEIAQFQAELAEARTQLQFLQKQLDEQLSKEPIGNQEMENLKWEVDQKEREIQALKQQLDLTEQQSTKELEGVQQSLQNIKSELEMAREDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKELKEATSSSPVTPVKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEAHTVTVHESLSSWTQGDPTSPSPPGDHANPRGDTERPGQSRASGEGLGTAAERPHHECL", "length": 1488 }, "evidence": [ { "id": "A0AAA9SFD3", "url": "https://omabrowser.org/oma/group/A0AAA9SFD3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08378-1", "protein_name": "Golgin subfamily A member 3", "gene_name": "GOLGA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLVPPDQQDKVQCAEVNRASTEGESPDGPGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKEGPGE", "length": 1498 }, "evidence": [ { "id": "A0AAA9SFD3", "url": "https://omabrowser.org/oma/group/A0AAA9SFD3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFD3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 606, "end_pos": 608, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 68, 1385 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 288, "end_pos": 290 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 606, "end_pos": 608 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFF4-1", "uniprot_ac": "A0AAA9SFF4", "uniprot_id": "A0AAA9SFF4_BOVIN", "mass": { "chemical_mass": 28496.0, "monoisotopic_mass": 28496.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "40S ribosomal protein S4", "type": "recommended", "evidence": [ { "id": "A0AAA9SFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00165", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00165", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11581", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11581", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11581:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11581:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00900", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00900", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQGPKKHLKRVAAPKHWMLDKLTGVFAPCPSTGPYKLRECLPLIIFLRNRLKYALTGDEVKKICMQHFIEIDGKVRTDITYPAGFMDVISIVKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIHYPDPLIKVNDTIQTDLETGKITDFIKFDTGNLCMVTGGANLRRIGVITNRERHPGSFDVVHVKDANGNSFAKRLSKHFRYWQRQQTVDLSSPWKGYSPYHC", "length": 249, "header": "tr|A0AAA9SFF4-1|A0AAA9SFF4_BOVIN Isoform 1 of 40S ribosomal protein S4 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SFF4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4/entry#A0AAA9SFF4-1", "sequence": { "sequence": "MAQGPKKHLKRVAAPKHWMLDKLTGVFAPCPSTGPYKLRECLPLIIFLRNRLKYALTGDEVKKICMQHFIEIDGKVRTDITYPAGFMDVISIVKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIHYPDPLIKVNDTIQTDLETGKITDFIKFDTGNLCMVTGGANLRRIGVITNRERHPGSFDVVHVKDANGNSFAKRLSKHFRYWQRQQTVDLSSPWKGYSPYHC", "length": 249, "header": "tr|A0AAA9SFF4-1|A0AAA9SFF4_BOVIN Isoform 1 of 40S ribosomal protein S4 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SFF4-1" }, "locus": { "chromosome": "3", "start_pos": 25810149, "end_pos": 25809403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117788.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117788.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082597.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082597.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" }, { "id": "PF08071", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08071" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Small ribosomal subunit protein eS4 N-terminal", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 39, "start_aa": "Gly", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF4" }, { "id": "PF00900", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00900" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Small ribosomal subunit protein eS4 central region", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 169, "start_aa": "Thr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFF8-1", "uniprot_ac": "A0AAA9SFF8", "uniprot_id": "A0AAA9SFF8_BOVIN", "mass": { "chemical_mass": 15040.0, "monoisotopic_mass": 15040.0 }, "refseq": {}, "gene_names": [ { "name": "RPL22", "type": "recommended", "evidence": [ { "id": "A0AAA9SFF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL22", "type": "recommended", "evidence": [ { "id": "A0AAA9SFF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L22", "type": "synonym", "evidence": [ { "id": "A0AAA9SFF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "F1N301", "url": "https://www.uniprot.org/uniprotkb/F1N301#function" }, { "database": "UniProtKB", "id": "ARBA00034092", "url": "https://www.uniprot.org/uniprotkb/ARBA00034092#function" }, { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8#function" }, { "database": "UniProtKB", "id": "A0AAA9TRC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8", "locus": { "chromosome": "16", "start_pos": 47152159, "end_pos": 47144239, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014423", "url": "https://www.ensembl.org/id/ENSBTAG00000014423" } ] } } ], "crossref": [ { "id": "A0AAA9SFF8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFF8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014423", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014423", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616065", "url": "https://www.ncbi.nlm.nih.gov/gene/616065", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616065", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616065", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IMEIGSF", "url": "https://omabrowser.org/oma/group/IMEIGSF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N301", "url": "https://www.orthodb.org/?gene=F1N301", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10064:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10064:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01776", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01776", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N301", "url": "https://www.uniprot.org/uniprotkb/F1N301", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N301-1", "url": "https://www.uniprot.org/uniprotkb/F1N301-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFCIQKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 130, "header": "tr|A0AAA9SFF8-1|A0AAA9SFF8_BOVIN Isoform 1 of Large ribosomal subunit protein eL22 OS=Bos taurus OX=9913 GN=RPL22 PE=1 SV=1 CANONICAL=A0AAA9SFF8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8/entry#A0AAA9SFF8-1", "sequence": { "sequence": "MGFCIQKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 130, "header": "tr|A0AAA9SFF8-1|A0AAA9SFF8_BOVIN Isoform 1 of Large ribosomal subunit protein eL22 OS=Bos taurus OX=9913 GN=RPL22 PE=1 SV=1 CANONICAL=A0AAA9SFF8-1" }, "locus": { "chromosome": "16", "start_pos": 47151597, "end_pos": 47144300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090303.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090303.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081188.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081188.1" } ] } }, { "isoform_ac": "A0AAA9TRC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8/entry#A0AAA9TRC0-1", "sequence": { "sequence": "KKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 124, "header": "tr|A0AAA9TRC0-1|A0AAA9TRC0_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL22 OS=Bos taurus OX=9913 GN=RPL22 PE=1 SV=2 CANONICAL=A0AAA9SFF8-1" }, "locus": { "chromosome": "16", "start_pos": 47151597, "end_pos": 47146275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096637.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096637.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098999.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098999.2" } ] } }, { "isoform_ac": "F1N301-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8/entry#F1N301-1", "sequence": { "sequence": "MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 128, "header": "tr|F1N301-1|F1N301_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL22 OS=Bos taurus OX=9913 GN=RPL22 PE=1 SV=2 CANONICAL=A0AAA9SFF8-1" }, "locus": { "chromosome": "16", "start_pos": 47151597, "end_pos": 47144481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019184.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019184.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019184.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019184.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616065", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616065", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P35268-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "RPL22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 128 }, "evidence": [ { "id": "A0AAA9SFF8", "url": "https://omabrowser.org/oma/group/A0AAA9SFF8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P47198-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "Rpl22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEEPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 128 }, "evidence": [ { "id": "A0AAA9SFF8", "url": "https://omabrowser.org/oma/group/A0AAA9SFF8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P67984-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "Rpl22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 128 }, "evidence": [ { "id": "A0AAA9SFF8", "url": "https://omabrowser.org/oma/group/A0AAA9SFF8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P67985-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "RPL22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED", "length": 128 }, "evidence": [ { "id": "A0AAA9SFF8", "url": "https://omabrowser.org/oma/group/A0AAA9SFF8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFH1-1", "uniprot_ac": "A0AAA9SFH1", "uniprot_id": "A0AAA9SFH1_BOVIN", "mass": { "chemical_mass": 19735.0, "monoisotopic_mass": 19735.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM18", "type": "recommended", "evidence": [ { "id": "A0AAA9SFH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1" } ] } ], "protein_names": [ { "name": "Transmembrane protein 18", "type": "recommended", "evidence": [ { "id": "A0AAA9SFH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1", "locus": { "chromosome": "8", "start_pos": 112477324, "end_pos": 112472794, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057706", "url": "https://www.ensembl.org/id/ENSBTAG00000057706" } ] } } ], "crossref": [ { "id": "A0AAA9SFH1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22593:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22593:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14770", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14770", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSZ7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SLADLRSSAVWRAAQIFRGFNHWSAAAKSLQPCPTLCDPIDGSPPGSPVPGILQQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE", "length": 174, "header": "tr|A0AAA9SFH1-1|A0AAA9SFH1_BOVIN Isoform 1 of Transmembrane protein 18 OS=Bos taurus OX=9913 GN=TMEM18 PE=3 SV=1 CANONICAL=A0AAA9SFH1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1/entry#A0AAA9SFH1-1", "sequence": { "sequence": "SLADLRSSAVWRAAQIFRGFNHWSAAAKSLQPCPTLCDPIDGSPPGSPVPGILQQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE", "length": 174, "header": "tr|A0AAA9SFH1-1|A0AAA9SFH1_BOVIN Isoform 1 of Transmembrane protein 18 OS=Bos taurus OX=9913 GN=TMEM18 PE=3 SV=1 CANONICAL=A0AAA9SFH1-1" }, "locus": { "chromosome": "8", "start_pos": 112476843, "end_pos": 112473499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132120.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132120.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081205.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081205.1" } ] } }, { "isoform_ac": "A0AAA9TWS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1/entry#A0AAA9TWS9-1", "sequence": { "sequence": "MPSAFSVSRFPVSIPAVITTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE", "length": 138, "header": "tr|A0AAA9TWS9-1|A0AAA9TWS9_BOVIN Computationally mapped isoform of Transmembrane protein 18 OS=Bos taurus OX=9913 GN=TMEM18 PE=3 SV=1 CANONICAL=A0AAA9SFH1-1" }, "locus": { "chromosome": "8", "start_pos": 112476843, "end_pos": 112473061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105851.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105851.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102816.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102816.1" } ] } }, { "isoform_ac": "A0ABI0NSZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1/entry#A0ABI0NSZ7-1", "sequence": { "sequence": "LSGHAQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE", "length": 125, "header": "tr|A0ABI0NSZ7-1|A0ABI0NSZ7_BOVIN Computationally mapped isoform of Transmembrane protein 18 OS=Bos taurus OX=9913 GN=TMEM18 PE=3 SV=1 CANONICAL=A0AAA9SFH1-1" }, "locus": { "chromosome": "8", "start_pos": 112476843, "end_pos": 112474107, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154930.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154930.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106247.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106247.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFH2-1", "uniprot_ac": "A0AAA9SFH2", "uniprot_id": "A0AAA9SFH2_BOVIN", "mass": { "chemical_mass": 18370.0, "monoisotopic_mass": 18370.0 }, "refseq": { "ac": "XP_002687992", "name": "desumoylating isopeptidase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687992" }, "gene_names": [ { "name": "DESI1", "type": "recommended", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] }, { "name": "DESI1", "type": "synonym", "evidence": [ { "id": "XP_002687992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687992" } ] } ], "protein_names": [ { "name": "Desumoylating isopeptidase 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#names_and_taxonomy" } ] }, { "name": "3.1.2.22", "type": "synonym", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#names_and_taxonomy" } ] }, { "name": "PPPDE peptidase domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#names_and_taxonomy" } ] }, { "name": "Palmitoyl protein thioesterase DESI1", "type": "synonym", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#names_and_taxonomy" } ] }, { "name": "S-depalmitoylase DESI1", "type": "synonym", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#names_and_taxonomy" } ] }, { "name": "desumoylating isopeptidase 1", "type": "synonym", "evidence": [ { "id": "XP_002687992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687992" } ] } ], "function": [ { "annotation": "Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2#function" }, { "database": "UniProtKB", "id": "ARBA00055399", "url": "https://www.uniprot.org/uniprotkb/ARBA00055399#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DESI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2", "locus": { "chromosome": "5", "start_pos": 112686400, "end_pos": 112706720, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047942", "url": "https://www.ensembl.org/id/ENSBTAG00000047942" } ] } } ], "crossref": [ { "id": "A0AAA9SFH2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "614655", "url": "https://www.ncbi.nlm.nih.gov/gene/614655", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008580", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008580", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614655", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614655", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HLMLGKQ", "url": "https://omabrowser.org/oma/group/HLMLGKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12378", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12378", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12378:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12378:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05903", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05903", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687992", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687992", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19233", "url": "https://www.rhea-db.org/rhea/19233", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T916", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T916", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T916-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T916-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGRTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRSEAYNIFENNCNTFSNEVAQFLTGRKIPSYITDLPSEILSTPFGQALRPFLDSIAIQPPGGSPVGRPNGQS", "length": 168, "header": "tr|A0AAA9SFH2-1|A0AAA9SFH2_BOVIN Isoform 1 of Desumoylating isopeptidase 1 OS=Bos taurus OX=9913 GN=DESI1 PE=3 SV=1 CANONICAL=A0AAA9SFH2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#A0AAA9SFH2-1", "sequence": { "sequence": "MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGRTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRSEAYNIFENNCNTFSNEVAQFLTGRKIPSYITDLPSEILSTPFGQALRPFLDSIAIQPPGGSPVGRPNGQS", "length": 168, "header": "tr|A0AAA9SFH2-1|A0AAA9SFH2_BOVIN Isoform 1 of Desumoylating isopeptidase 1 OS=Bos taurus OX=9913 GN=DESI1 PE=3 SV=1 CANONICAL=A0AAA9SFH2-1" }, "locus": { "chromosome": "5", "start_pos": 112706369, "end_pos": 112687404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096595.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096595.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082618.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082618.1" } ] } }, { "isoform_ac": "A0AAA9T916-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2/entry#A0AAA9T916-1", "sequence": { "sequence": "GHYAHARKCVPAPALSFALTVPSPLCHLTVAGGGCWGASSPGRPLPAPQAGPGLGLLFRPLPSPVGYGKVQAAAGCLRDFVAAAATGPDGAAESLSGEALRVRPVQGLGPAAQPHHVGHTSIVVHKDEFFFGSGGISSCPPGRTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRSEAYNIFENNCNTFSNEVAQFLTGRKIPSYITDLPSEILSTPFGQALRPFLDSIAIQPPGGSPVGRPNGQS", "length": 249, "header": "tr|A0AAA9T916-1|A0AAA9T916_BOVIN Computationally mapped isoform of palmitoyl-protein hydrolase OS=Bos taurus OX=9913 GN=DESI1 PE=3 SV=1 CANONICAL=A0AAA9SFH2-1" }, "locus": { "chromosome": "5", "start_pos": 112706634, "end_pos": 112687404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133023.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133023.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094481.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094481.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614655", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614655", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3B0Z9-1", "protein_name": "palmitoyl-protein hydrolase", "gene_name": "DESI1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEPPALHPVKLYVYDLSKGMARRLSPLMLGKQLDGIWHTSIIVHKDEFYYGAGGISSCAPGGTLLGPPDSVIDLGNTEVTEEIFLEYLSSLGESMFRSESYHFFERNCNTFSNEVAQFLTGRKIPSYITDLPSEVLATPFGQALRPFLSTTQFHPPGGNTFNRDNGQS", "length": 169 }, "evidence": [ { "id": "A0AAA9SFH2", "url": "https://omabrowser.org/oma/group/A0AAA9SFH2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JB89-1", "protein_name": "palmitoyl-protein hydrolase", "gene_name": "Desi1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDTVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTAQTAPTTEVSSAPDGVSALGRSLWAITQLSSLKGPKLPKGI", "length": 179 }, "evidence": [ { "id": "A0AAA9SFH2", "url": "https://omabrowser.org/oma/group/A0AAA9SFH2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6ICB0-1", "protein_name": "Desumoylating isopeptidase 1", "gene_name": "DESI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS", "length": 168 }, "evidence": [ { "id": "A0AAA9SFH2", "url": "https://omabrowser.org/oma/group/A0AAA9SFH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQT7-1", "protein_name": "Desumoylating isopeptidase 1", "gene_name": "Desi1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSSGISSCTPGGTLLGPPDSVVDVGNTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPFLDSIQIQPPGGNSVGRPNGQS", "length": 168 }, "evidence": [ { "id": "A0AAA9SFH2", "url": "https://omabrowser.org/oma/group/A0AAA9SFH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "protein export from nucleus", "id": "GO:0006611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006611", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032434", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "protein desumoylation", "id": "GO:0016926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016926", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "deSUMOylase activity", "id": "GO:0016929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "importin-alpha family protein binding", "id": "GO:0061676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" }, { "name": "long-chain fatty acyl-CoA hydrolase activity", "id": "GO:0052816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052816", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19233", "name": "", "equation": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T2L1-1", "A0AAA9SCF5-1", "A0AAA9SFH2-1", "A0A3Q1M5Z8-1", "G3MWX2-1", "A0AAF6YMI2-1", "A5PKD9-1", "P45478-1", "Q3MHR0-1", "Q1ZYR0-1", "Q5E9H9-1", "F1MNH5-1", "Q2HJ19-1", "A0AAA9S0E0-1", "F1MYM8-1", "F6RC73-1", "F1N587-1" ], "evidence": [ { "id": "19233", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19233" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M5Z8", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] } ] }, { "uniprot_ac": "A0AAA9S0E0", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] } ] }, { "uniprot_ac": "A0AAA9SCF5", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] } ] }, { "uniprot_ac": "A0AAA9SFH2", "gene_name": "DESI1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] } ] }, { "uniprot_ac": "A0AAA9T2L1", "gene_name": "ABHD17B", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ] } ] }, { "uniprot_ac": "A0AAF6YMI2", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.1.93", "activity": "mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+).", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.1.93", "activity": "", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] } ] }, { "uniprot_ac": "A5PKD9", "gene_name": "ABHD17C", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A5PKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKD9" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A5PKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKD9" } ] } ] }, { "uniprot_ac": "F1MNH5", "gene_name": "DESI2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] } ] }, { "uniprot_ac": "F1MYM8", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1MYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1MYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM8" } ] } ] }, { "uniprot_ac": "F1N587", "gene_name": "CPT1C", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] } ] }, { "uniprot_ac": "F6RC73", "gene_name": "LYPLAL1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F6RC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RC73" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F6RC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RC73" } ] } ] }, { "uniprot_ac": "G3MWX2", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] } ] }, { "uniprot_ac": "P45478", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] } ] }, { "uniprot_ac": "Q1ZYR0", "gene_name": "CLN5", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] } ] }, { "uniprot_ac": "Q2HJ19", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q2HJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ19" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q2HJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ19" } ] } ] }, { "uniprot_ac": "Q3MHR0", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] } ] }, { "uniprot_ac": "Q5E9H9", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] }, { "ec_number": "3.1.1.93", "activity": "mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+).", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" }, { "id": "PS51858", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51858" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPPDE", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 149, "start_aa": "Tyr", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.22", "ec_name": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "3.1.2.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22" }, { "id": "3.1.2.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFL5-1", "uniprot_ac": "A0AAA9SFL5", "uniprot_id": "A0AAA9SFL5_BOVIN", "mass": { "chemical_mass": 35425.0, "monoisotopic_mass": 35425.0 }, "refseq": {}, "gene_names": [ { "name": "OR5D14", "type": "recommended", "evidence": [ { "id": "A0AAA9SFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5D14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5", "locus": { "chromosome": "28", "start_pos": 74395, "end_pos": 73451, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069872", "url": "https://www.ensembl.org/id/ENSBTAG00000069872" } ] } } ], "crossref": [ { "id": "A0AAA9SFL5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15410", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15410", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "IVMTARNMSLETTFALLGFTDYPELQIPLFLVFLIMYIITVVGNLGMIVIIKINPKFHNPMYFFLSHLSFVDFCYSSIVTPKLLENLVMADKSIFYTSCMLQYFLSCTAVVTESFLLAMMAYDRFVAICNPLLYTVVMSQRLCALLVSGSYLWGMFGPLVLLCYALQLSFSGHTVINHFFCEYTALIAVSSSNTHIPHLLLFTFATFNEVSTLLIILTSYVFIFVTVLNIRSASGRRKAFSTCASHLTAITIFHGTILSLYCVPNSKNSRQTVKVASVFYTVVNPMLNPLIYSLRNKDVKDAFQKLIDTKASFH", "length": 314, "header": "tr|A0AAA9SFL5-1|A0AAA9SFL5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5D14 PE=3 SV=1 CANONICAL=A0AAA9SFL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5/entry#A0AAA9SFL5-1", "sequence": { "sequence": "IVMTARNMSLETTFALLGFTDYPELQIPLFLVFLIMYIITVVGNLGMIVIIKINPKFHNPMYFFLSHLSFVDFCYSSIVTPKLLENLVMADKSIFYTSCMLQYFLSCTAVVTESFLLAMMAYDRFVAICNPLLYTVVMSQRLCALLVSGSYLWGMFGPLVLLCYALQLSFSGHTVINHFFCEYTALIAVSSSNTHIPHLLLFTFATFNEVSTLLIILTSYVFIFVTVLNIRSASGRRKAFSTCASHLTAITIFHGTILSLYCVPNSKNSRQTVKVASVFYTVVNPMLNPLIYSLRNKDVKDAFQKLIDTKASFH", "length": 314, "header": "tr|A0AAA9SFL5-1|A0AAA9SFL5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5D14 PE=3 SV=1 CANONICAL=A0AAA9SFL5-1" }, "locus": { "chromosome": "28", "start_pos": 74392, "end_pos": 73451, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091411.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091411.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082664.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 292, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFL8-1", "uniprot_ac": "A0AAA9SFL8", "uniprot_id": "A0AAA9SFL8_BOVIN", "mass": { "chemical_mass": 34206.0, "monoisotopic_mass": 34206.0 }, "refseq": {}, "gene_names": [ { "name": "OR8G3", "type": "recommended", "evidence": [ { "id": "A0AAA9SFL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SFL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8G3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFL8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPGNHSSVTEFILAGLTEKPELQIPLLVFFLGIYSVTVVGNLGMITLIGLSSHLHTPMYYFLTNLSFIDFCHSTVVTPKMLVNFVTEKNIISYPECMTQLYFFIVFIIAECHMLAVMAYDRYVAICNPLLYNVIMSYYRCFQLTVTVYILCIIESAIHTGFMLRLYFCKANVINHYFCDLFPLLELSCSSISMNELLALVFSAFNVLIPVLTILASYIFILSSILQIHSTEGRSKAFSTCSSHISAVVVFYGSVAFMYLQPSSVSSMEQGKVSSVFYTCIVPMLNPLIYSLRNKDVKFALKK", "length": 303, "header": "tr|A0AAA9SFL8-1|A0AAA9SFL8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G3 PE=3 SV=1 CANONICAL=A0AAA9SFL8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8/entry#A0AAA9SFL8-1", "sequence": { "sequence": "MDPGNHSSVTEFILAGLTEKPELQIPLLVFFLGIYSVTVVGNLGMITLIGLSSHLHTPMYYFLTNLSFIDFCHSTVVTPKMLVNFVTEKNIISYPECMTQLYFFIVFIIAECHMLAVMAYDRYVAICNPLLYNVIMSYYRCFQLTVTVYILCIIESAIHTGFMLRLYFCKANVINHYFCDLFPLLELSCSSISMNELLALVFSAFNVLIPVLTILASYIFILSSILQIHSTEGRSKAFSTCSSHISAVVVFYGSVAFMYLQPSSVSSMEQGKVSSVFYTCIVPMLNPLIYSLRNKDVKFALKK", "length": 303, "header": "tr|A0AAA9SFL8-1|A0AAA9SFL8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G3 PE=3 SV=1 CANONICAL=A0AAA9SFL8-1" }, "locus": { "chromosome": "29", "start_pos": 27504016, "end_pos": 27503108, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100887.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100887.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082403.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFL8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFM7-1", "uniprot_ac": "A0AAA9SFM7", "uniprot_id": "A0AAA9SFM7_BOVIN", "mass": { "chemical_mass": 59472.0, "monoisotopic_mass": 59472.0 }, "refseq": { "ac": "XP_024844485", "name": "cytochrome P450, family 4, subfamily A, polypeptide 22 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844485" }, "gene_names": [ { "name": "CYP4A22", "type": "recommended", "evidence": [ { "id": "A0AAA9SFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ] }, { "name": "CYP4A22", "type": "synonym", "evidence": [ { "id": "XP_024844485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844485" } ] } ], "protein_names": [ { "name": "Cytochrome P450, family 4, subfamily A, polypeptide 22", "type": "synonym", "evidence": [ { "id": "A0AAA9SFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7/entry#names_and_taxonomy" } ] }, { "name": "cytochrome P450, family 4, subfamily A, polypeptide 22 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024844485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844485" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYP4A22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7", "locus": { "chromosome": "3", "start_pos": 99334690, "end_pos": 99319612, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013481", "url": "https://www.ensembl.org/id/ENSBTAG00000013481" } ] } } ], "crossref": [ { "id": "A0AAA9SFM7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20678", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20678", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516085", "url": "https://www.ncbi.nlm.nih.gov/gene/516085", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVSVLSPTRALGGVSGLLQVVSLLGLVLLLLKAAQLYLRRQWLLKALHQFPSPPSHWFYGHKKEFQKESELPPLLERVEKYPKACVRWLWGTKALVLVYDPDYMKVFLGRSDPKPHRTYKYLAPWIGTGLLLLEGQKWFQHRRMLTPAFRYDILKAYVGIMADSVRVMLDKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSHQGSVQMDRSSQSYIQAIRDLSHLIVSRLRNAFHQNDLIYRLTPEGRWNHRACQLTHQHTDAVIKERKAHLQKEGELEKVRSRRHLDFLDILLLARMENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITWDHLDQMRYTTMCIKEAMRLYPPVPFIGRELRKPITFPDGRSLPAGILVSLSFYGLHHNPNVWPNPEVFDPTRFSPGSTQHSYAFLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELSPDPSRVPVPTPIMVLRSKNGIHLQLRKLSDPGGDKDKL", "length": 519, "header": "tr|A0AAA9SFM7-1|A0AAA9SFM7_BOVIN Isoform 1 of Cytochrome P450, family 4, subfamily A, polypeptide 22 OS=Bos taurus OX=9913 GN=CYP4A22 PE=3 SV=1 CANONICAL=A0AAA9SFM7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7/entry#A0AAA9SFM7-1", "sequence": { "sequence": "MSVSVLSPTRALGGVSGLLQVVSLLGLVLLLLKAAQLYLRRQWLLKALHQFPSPPSHWFYGHKKEFQKESELPPLLERVEKYPKACVRWLWGTKALVLVYDPDYMKVFLGRSDPKPHRTYKYLAPWIGTGLLLLEGQKWFQHRRMLTPAFRYDILKAYVGIMADSVRVMLDKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSHQGSVQMDRSSQSYIQAIRDLSHLIVSRLRNAFHQNDLIYRLTPEGRWNHRACQLTHQHTDAVIKERKAHLQKEGELEKVRSRRHLDFLDILLLARMENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITWDHLDQMRYTTMCIKEAMRLYPPVPFIGRELRKPITFPDGRSLPAGILVSLSFYGLHHNPNVWPNPEVFDPTRFSPGSTQHSYAFLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELSPDPSRVPVPTPIMVLRSKNGIHLQLRKLSDPGGDKDKL", "length": 519, "header": "tr|A0AAA9SFM7-1|A0AAA9SFM7_BOVIN Isoform 1 of Cytochrome P450, family 4, subfamily A, polypeptide 22 OS=Bos taurus OX=9913 GN=CYP4A22 PE=3 SV=1 CANONICAL=A0AAA9SFM7-1" }, "locus": { "chromosome": "3", "start_pos": 99333652, "end_pos": 99319651, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091410.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091410.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084178.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084178.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 491, "start_aa": "Thr", "end_pos": 491, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr491", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 491 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 302, "end_pos": 304 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFR4-1", "uniprot_ac": "A0AAA9SFR4", "uniprot_id": "A0AAA9SFR4_BOVIN", "mass": { "chemical_mass": 90322.0, "monoisotopic_mass": 90322.0 }, "refseq": {}, "gene_names": [ { "name": "WHAMM", "type": "recommended", "evidence": [ { "id": "A0AAA9SFR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ] } ], "protein_names": [ { "name": "WASP homolog associated with actin, golgi membranes and microtubules", "type": "synonym", "evidence": [ { "id": "A0AAA9SFR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WHAMM", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4", "locus": { "chromosome": "21", "start_pos": 23100087, "end_pos": 23081878, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017711", "url": "https://www.ensembl.org/id/ENSBTAG00000017711" } ] } } ], "crossref": [ { "id": "A0AAA9SFR4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017711", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017711", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23330", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23330", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23330:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23330:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15871", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15871", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD74", "url": "https://www.uniprot.org/uniprotkb/E1BD74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD74-1", "url": "https://www.uniprot.org/uniprotkb/E1BD74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDEQPDSLEGWVPVREDLFAEPERHQLRFLVAWNDVEGKFAVTCHDRTAQRRRWREGSQAGPEPAPEPEAAAPPPSWAGLLSAAGLRGAHRQLAALWPPLEPCFPRLPPELDVGGGGAWGLGLGLWTLVWPAPTGPGEAALQELCRQLERYLGQAADGCGGAAVRDALFPGQRCAADCESTREFRERALRARRDEASARLRQLLQGHEKANTMVALMNVYREEDEAYQELVTATTMFFQYLLQPFRDMRELATSCKLAILKSLDEDDLGPKRIVALQKEAQEWTRQAEEAIVSIQDITVNYFEKTVEALAGMKKQMAQDEKRFGQAAWATATPRLEKLKLMLAREALQLMRAKELCLNHRRAEIRGKMEDLPEQEKKINIVDDLEIQYYEVQLELYEVKFEILKYEEILLVTQLDSIKRLIKDKQDEVIYYDPCESPEELTVMDGVMGLQEGKQLEVGVLSRQCQQLESKRGSICARRARLRNRKDQCKENHRLRLQQAEERIKYSHQHHSVQRKRDKKKEEEQKKREWINQERQKTLQRLRAFKERCPGQPVLKSSRSQPVTPDLPNGLPKQTPPPTSQMTAVIHPSSRKTRSAPLSEVSTVKTPEREDCAGDSPVPTLVPTGDQTHSTSSEELLPPPLPPPPPPPPPPPPPPLPAQPFSSQPANHRNLRFGTSVKDDQPLPLVCESPTENPRGPADSFSGPGSMDEVLASLRHGRAPPQKVQAPALPPPRASVNEHILAAIRQGVKLKKVHPAPGPSPSSKPTSDLEKSIKAALQRIKRVSADSEEEGEEGDEQGPHEWDH", "length": 804, "header": "tr|A0AAA9SFR4-1|A0AAA9SFR4_BOVIN Isoform 1 of WASP homolog associated with actin, golgi membranes and microtubules OS=Bos taurus OX=9913 GN=WHAMM PE=4 SV=1 CANONICAL=A0AAA9SFR4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4/entry#A0AAA9SFR4-1", "sequence": { "sequence": "MEDEQPDSLEGWVPVREDLFAEPERHQLRFLVAWNDVEGKFAVTCHDRTAQRRRWREGSQAGPEPAPEPEAAAPPPSWAGLLSAAGLRGAHRQLAALWPPLEPCFPRLPPELDVGGGGAWGLGLGLWTLVWPAPTGPGEAALQELCRQLERYLGQAADGCGGAAVRDALFPGQRCAADCESTREFRERALRARRDEASARLRQLLQGHEKANTMVALMNVYREEDEAYQELVTATTMFFQYLLQPFRDMRELATSCKLAILKSLDEDDLGPKRIVALQKEAQEWTRQAEEAIVSIQDITVNYFEKTVEALAGMKKQMAQDEKRFGQAAWATATPRLEKLKLMLAREALQLMRAKELCLNHRRAEIRGKMEDLPEQEKKINIVDDLEIQYYEVQLELYEVKFEILKYEEILLVTQLDSIKRLIKDKQDEVIYYDPCESPEELTVMDGVMGLQEGKQLEVGVLSRQCQQLESKRGSICARRARLRNRKDQCKENHRLRLQQAEERIKYSHQHHSVQRKRDKKKEEEQKKREWINQERQKTLQRLRAFKERCPGQPVLKSSRSQPVTPDLPNGLPKQTPPPTSQMTAVIHPSSRKTRSAPLSEVSTVKTPEREDCAGDSPVPTLVPTGDQTHSTSSEELLPPPLPPPPPPPPPPPPPPLPAQPFSSQPANHRNLRFGTSVKDDQPLPLVCESPTENPRGPADSFSGPGSMDEVLASLRHGRAPPQKVQAPALPPPRASVNEHILAAIRQGVKLKKVHPAPGPSPSSKPTSDLEKSIKAALQRIKRVSADSEEEGEEGDEQGPHEWDH", "length": 804, "header": "tr|A0AAA9SFR4-1|A0AAA9SFR4_BOVIN Isoform 1 of WASP homolog associated with actin, golgi membranes and microtubules OS=Bos taurus OX=9913 GN=WHAMM PE=4 SV=1 CANONICAL=A0AAA9SFR4-1" }, "locus": { "chromosome": "21", "start_pos": 23099224, "end_pos": 23081976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119150.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119150.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082715.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082715.1" } ] } }, { "isoform_ac": "E1BD74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4/entry#E1BD74-1", "sequence": { "sequence": "MEDEQPDSLEGWVPVREDLFAEPERHQLRFLVAWNDVEGKFAVTCHDRTAQRRRWREGSQAGPEPAPEPEAAAPPPSWAGLLSAAGLRGAHRQLAALWPPLEPCFPRLPPELDVGGGGAWGLGLGLWTLVWPAPTGPGEAALQELCRQLERYLGQAADGCGGAAVRDALFPGQRCAADCESTREFRERALRARRDEASARLRQLLQGHEKANTMVALMNVYREEDEAYQELVTATTMFFQYLLQPFRDMRELATSCKLAILKSLDEDDLGPKRIVALQKEAQEWTRQAEEAIVSIQDITVNYFEKTVEALAGMKKQMAQDEKRFGQAAWATATPRLEKLKLMLAREALQLMRAKELCLNHRRAEIRGKMEDLPEQEKKINIVDDLEIQYYEVQLELYEVKFEILKYEEILLVTQLDSIKRLIKDKQDEVIYYDPCESPEELTVMDGVMGLQEGKQLEVGVLSRQCQQLESKRGSICARRARLRNRKDQCKENHRLRLQQAEERIKYSHQHHSVQRKRDKKKEEEQKKREWINQERQKTLQRLRAFKERCPGQPVLKSSRSQPVTPDLPNGLPKQTPPPTSQMTAVIHPSSRKTRSAPLSEVSTVKTPEREDCAGDSPVPTLVSLVTKHIPRQVRNCCRRRCLRLPPPPPPPPPPLPAQPFSSQPANHRNLRFGTSVKDDQPLPLVCESPTENPRGPADSFSGPGSMDEVLASLRHGRAPPQKVQAPALPPPRASVNEHILAAIRQGVKLKKVHPAPGPSPSSKPTSDLEKSIKAALQRIKRVSADSEEEGEEGDEQGPHEWDH", "length": 803, "header": "tr|E1BD74-1|A0AAA9SFR4_BOVIN Computationally mapped isoform of WASP homolog associated with actin, golgi membranes and microtubules OS=Bos taurus OX=9913 GN=WHAMM PE=4 SV=4 CANONICAL=A0AAA9SFR4-1" }, "locus": { "chromosome": "21", "start_pos": 23099224, "end_pos": 23081976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023556.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023556.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023556.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023556.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "id": "GO:0033116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "Arp2/3 complex binding", "id": "GO:0071933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071933", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "lamellipodium assembly", "id": "GO:0030032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030032", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "focal adhesion assembly", "id": "GO:0048041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "positive regulation of actin nucleation", "id": "GO:0051127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051127", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" }, { "name": "plasma membrane tubulation", "id": "GO:0097320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097320", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFR4" }, { "id": "PS51082", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WH2", "eco_id": "ECO_0000259", "start_pos": 736, "end_pos": 753, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFS0-1", "uniprot_ac": "A0AAA9SFS0", "uniprot_id": "A0AAA9SFS0_BOVIN", "mass": { "chemical_mass": 57999.0, "monoisotopic_mass": 57999.0 }, "refseq": { "ac": "NP_001193990", "name": "ankyrin repeat domain-containing protein 34C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193990" }, "gene_names": [ { "name": "ANKRD34C", "type": "recommended", "evidence": [ { "id": "A0AAA9SFS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0" } ] }, { "name": "ANKRD34C", "type": "synonym", "evidence": [ { "id": "NP_001193990", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193990" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 34C", "type": "synonym", "evidence": [ { "id": "A0AAA9SFS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 34C", "type": "synonym", "evidence": [ { "id": "NP_001193990", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193990" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD34C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0", "locus": { "chromosome": "21", "start_pos": 25506738, "end_pos": 25500696, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062558", "url": "https://www.ensembl.org/id/ENSBTAG00000062558" } ] } } ], "crossref": [ { "id": "A0AAA9SFS0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "100297143", "url": "https://www.ncbi.nlm.nih.gov/gene/100297143", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100297143", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297143", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EQQNTVF", "url": "https://omabrowser.org/oma/group/EQQNTVF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24156:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24156:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193990", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGDVVSLLLENGADPSLEDRTGASALVYAINADDKDALRHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPLPKEEDRQSPPPCASPSEVELKAPGLGSPPSEKEDGFFSLQSGHPSSCNSAKALNEPGSPTRKVGNLKKARLPQLKRLQSEPWGLTAPSVLAASCVRQDETHGVGMDGEVKSIGDVSFPRRGPLSRTSSIDGKDASLVHTVTEQVVKIPVSSASASWKAAYEKTQAPHPRLARRGTLPIDQEKVGICPVGPSALKDTMTLKWLENDLYDLELHPGADLPNPISLESGKGPLDRKKLNSSYLSLFQGSRESLDAVSSTSPNSARRRPPHLLERRGSGTLLLDRISQTRPGFLPPLNVNLNPPIPDIRVSSKPSSPLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQVEQMKQLSDFEETMT", "length": 535, "header": "tr|A0AAA9SFS0-1|A0AAA9SFS0_BOVIN Isoform 1 of Ankyrin repeat domain 34C OS=Bos taurus OX=9913 GN=ANKRD34C PE=3 SV=1 CANONICAL=A0AAA9SFS0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS0/entry#A0AAA9SFS0-1", "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGDVVSLLLENGADPSLEDRTGASALVYAINADDKDALRHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPLPKEEDRQSPPPCASPSEVELKAPGLGSPPSEKEDGFFSLQSGHPSSCNSAKALNEPGSPTRKVGNLKKARLPQLKRLQSEPWGLTAPSVLAASCVRQDETHGVGMDGEVKSIGDVSFPRRGPLSRTSSIDGKDASLVHTVTEQVVKIPVSSASASWKAAYEKTQAPHPRLARRGTLPIDQEKVGICPVGPSALKDTMTLKWLENDLYDLELHPGADLPNPISLESGKGPLDRKKLNSSYLSLFQGSRESLDAVSSTSPNSARRRPPHLLERRGSGTLLLDRISQTRPGFLPPLNVNLNPPIPDIRVSSKPSSPLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQVEQMKQLSDFEETMT", "length": 535, "header": "tr|A0AAA9SFS0-1|A0AAA9SFS0_BOVIN Isoform 1 of Ankyrin repeat domain 34C OS=Bos taurus OX=9913 GN=ANKRD34C PE=3 SV=1 CANONICAL=A0AAA9SFS0-1" }, "locus": { "chromosome": "21", "start_pos": 25502300, "end_pos": 25500696, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132799.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132799.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081311.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081311.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297143", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297143", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNJ4-1", "protein_name": "Ankyrin repeat domain 34C", "gene_name": "ANKRD34C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACRAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKETDRQSPPLCASPSDIELKAPGLGCPPSEKEDDFFSLQAGHPSGCNTSKALNDPGSPTRKVGNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDENHGVGTDNEVIKSISDVSFPKRGPLSRTNSIDSKDPSLFHTVTEQVLKIPASSAPASWKAAYEKSQASHPRLARRGTLPIDQEKGGISPSGPSALKDAVSLKRLENDLYDLDLQAGTELPNSISLEPGKGPLDRMKLNSSHLSLFQGSRESLDTVPSTSPSSARHRPPHLLERRGSGTLLLDRISQTRPGFLPPLNVNLNPPIPDIRSSSKPSSPLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQVEQMKQLSDFEEIMT", "length": 535 }, "evidence": [ { "id": "A0AAA9SFS0", "url": "https://omabrowser.org/oma/group/A0AAA9SFS0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZI64-1", "protein_name": "Ankyrin repeat domain 34C", "gene_name": "Ankrd34c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRQSPPLCATPSDVELKASGLSSPPSEKDDDFFILQTGHQSCCSTSKVLNEPGSPTRKVSSLKRARLPQLKRLQSEPWGLIAPSVLAAAARQDETHGTSTDNEVIRSINDLSFPKRGPLSRANSIDSKDPTMFPTVQEQVLKVSSSTPASWKAAYEKGQAPHPRLARRGTLPVDQEKCGMCPPGPSTLKDTASLKMLENDLYDLDIQPGGDPPNSMSLESGKGPLDRKKLNSSHLSLFHGSRESLDAVPSTSPSSVRRRPPHLLERRGSGTLLLDRIAHTRPGFLPPLNVNLNPPIPDIRASNKPASPLASGLKSMVPVAPNSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMA", "length": 534 }, "evidence": [ { "id": "A0AAA9SFS0", "url": "https://omabrowser.org/oma/group/A0AAA9SFS0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QC31-1", "protein_name": "Ankyrin repeat domain-containing protein 34C", "gene_name": "ankrd34c", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADVLELRTDGNSLLKAVWLRRLRLTRLLLEGGAYINESNDRGETPLMVACMSKHSDQQSVSKAKLVKYLLDNKADPNIQDKAGRSALMHACSHRAGHEVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLDACKAKGKEVIIITTDKSPSGTKTTKQYLNVPPSPELDERATPAPCASPSEIDLHASPSPSKEEEKDTVFNFQTKFKSTSSTAAKLPNGLTSPSKKPANPKRARLPQLKRLQSEPWGLIAPSVLAAANEESKRANSDEDVVAGVNGLSLSRRGTLSRHNSVDGKDILFPMMGDQNTKISPTSSLPPSSKASYERSLAQHQPLARRSTVPTEQEASGVNFGPASLRDTVHRRRLGTEHYDSDSQLYSDSSMLDSPKAPLERRKLNTSPLAMLTGSRESLDSNPSTSSPSTARCRAPGLLERRGSGTLLLDYISHTRPGHLPPLNVNPNPPIPDIGASSKPSSPLAAGIRLIAPVAPNSPKRGNLRTKKKLVRRHSMQVEQMKQLSNFEELNHQS", "length": 531 }, "evidence": [ { "id": "A0AAA9SFS0", "url": "https://omabrowser.org/oma/group/A0AAA9SFS0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3GTA8-1", "protein_name": "Ankyrin repeat domain-containing protein 34C", "gene_name": "Ankrd34c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRQSPPLCASPSDIELKAPSLDSPPSEKDDDFFILQSGHQSGCSTSKALNEPGSPTRKVSSLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGTSTDNEIVRSINDISFPKRGPLSRANSIDSKDCTLFPTVQEQVLKVPASAPATWKAAYEKGQAPHPRLARRGTTLPVDQEKAGMCPPGPSALKDPASLKLLENDLYDLDVQPGADPPNTMSLESAKGPLDRKKLNSSHLSLFHGSRECLDAVPSTSPSSVRRRPPHLLERRGSGTLLLDRIAHTRPGFLPPLNVNSNPPIPDIRASSKPAAPLAGGLKSMVPIAPNSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMT", "length": 535 }, "evidence": [ { "id": "A0AAA9SFS0", "url": "https://omabrowser.org/oma/group/A0AAA9SFS0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0C6C1-1", "protein_name": "Ankyrin repeat domain-containing protein 34C", "gene_name": "ANKRD34C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRHSPPLCASPSDIELKALGLDSPLTEKEDDFFSLQAGHPSSCNTSKAVNEPGSPTRKVSNLKRARLPQLKRLQSEPWGLIAPSVLAASTRQDETHGASTDNEVIKSISDISFPKRGPLSRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEKCGMGPSGPSALKEPASLKWLENDLYDLDIQPGPDPPNSISLESGKGPLDRKKLNSSHLSLFHGSRESLDTVPSTSPSSARRRPPHLLERRGSGTLLLDRISHTRPGFLPPLNVNLNPPIPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMT", "length": 535 }, "evidence": [ { "id": "A0AAA9SFS0", "url": "https://omabrowser.org/oma/group/A0AAA9SFS0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BLB8-1", "protein_name": "Ankyrin repeat domain-containing protein 34C", "gene_name": "Ankrd34c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQSISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRQSPPLCTTPSDVELKTSGLASPPSEKDDDFFILQTGHQSGCSTSKVLNEPGSPTRKVSSLKRARLPQLKRLQSEPWGLIAPSVLAAATRQDETHGTSTDNEVIRSINDVTFPKRGPLSRTNSIDSKDPTLFPTVQEQVLKVSASTPASWKAAYEKGQAPHPRLARRGTLPLDQEKSGMCPPGPSTLKDPASLKLLENDLYDLDIQPVGDPPNSMSLESGKGPLDRKKLNSSHLSLFHGSRESLEVVPSTSPTSVRRRPPHLLERRGSGTLLLDRIAHTRPGFLPPLNVNLNPPIPDIRASSKPASPLASGLKSMAPVAPNSPKRVDLRSKKKLLRRHSMQIEQMKQLSDFEEIMA", "length": 534 }, "evidence": [ { "id": "A0AAA9SFS0", "url": "https://omabrowser.org/oma/group/A0AAA9SFS0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 }, { "start_pos": 409, "end_pos": 411 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFS1-1", "uniprot_ac": "A0AAA9SFS1", "uniprot_id": "A0AAA9SFS1_BOVIN", "mass": { "chemical_mass": 26944.0, "monoisotopic_mass": 26944.0 }, "refseq": {}, "gene_names": [ { "name": "LOC514170", "type": "recommended", "evidence": [ { "id": "A0AAA9SFS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1" } ] } ], "protein_names": [ { "name": "Cystatin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SFS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC514170", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFS1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11414:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11414:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R4G4", "url": "https://www.uniprot.org/uniprotkb/F6R4G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R4G4-1", "url": "https://www.uniprot.org/uniprotkb/F6R4G4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "AGGSFSSPPLAALRSAAPVSPGSCGTRRTGDSHHPPTRVDPFLSGDSVGAAPHYHTHPAGSSHPCLVTLPPRGRYRSPAPAESEHVPEWDQDFPSLFPVPQPRHLSWLHPRITGPSLQVWQFPISSPVLGVSAAPTAHPPSLPTADMWGPNLGGFSDTQDATAEIQAIADQVKSQLEEKENKKFPVFKAVKFRSQVVAGMNYLIKVQVDEDDFVHIRVFESLPHENKPVALTSYQTNKSRHDELTYF", "length": 247, "header": "tr|A0AAA9SFS1-1|A0AAA9SFS1_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC514170 PE=3 SV=1 CANONICAL=A0AAA9SFS1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1/entry#A0AAA9SFS1-1", "sequence": { "sequence": "AGGSFSSPPLAALRSAAPVSPGSCGTRRTGDSHHPPTRVDPFLSGDSVGAAPHYHTHPAGSSHPCLVTLPPRGRYRSPAPAESEHVPEWDQDFPSLFPVPQPRHLSWLHPRITGPSLQVWQFPISSPVLGVSAAPTAHPPSLPTADMWGPNLGGFSDTQDATAEIQAIADQVKSQLEEKENKKFPVFKAVKFRSQVVAGMNYLIKVQVDEDDFVHIRVFESLPHENKPVALTSYQTNKSRHDELTYF", "length": 247, "header": "tr|A0AAA9SFS1-1|A0AAA9SFS1_BOVIN Isoform 1 of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC514170 PE=3 SV=1 CANONICAL=A0AAA9SFS1-1" }, "locus": { "chromosome": "1", "start_pos": 143824090, "end_pos": 143819698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092637.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092637.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084220.1" } ] } }, { "isoform_ac": "F6R4G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1/entry#F6R4G4-1", "sequence": { "sequence": "DRPERVGRWAWLGDEGLQGARAGRTEAQAAPAPLLQLLQVLSWRELLLSALGSSQVCCSRVSRLLWNPKDRHLSWLHPRITGPSLQVWQFPISSPVLGVSAAPTAHPPSLPTADMWGPNLGGFSDTQDATAEIQAIADQVKSQLEEKENKKFPVFKAVKFRSQVVAGMNYLIKVQVDEDDFVHIRVFESLPHENKPVALTSYQTNKSRHDELTYF", "length": 215, "header": "tr|F6R4G4-1|F6R4G4_BOVIN Computationally mapped isoform of Cystatin domain-containing protein OS=Bos taurus OX=9913 GN=LOC514170 PE=3 SV=1 CANONICAL=A0AAA9SFS1-1" }, "locus": { "chromosome": "1", "start_pos": 143824214, "end_pos": 143819698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024208.4", "url": "https://www.ensembl.org/id/ENSBTAT00000024208.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024208.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024208.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS1" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 150, "end_pos": 247, "start_aa": "Pro", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 237, "end_pos": 239 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFS8-1", "uniprot_ac": "A0AAA9SFS8", "uniprot_id": "A0AAA9SFS8_BOVIN", "mass": { "chemical_mass": 44950.0, "monoisotopic_mass": 44950.0 }, "refseq": {}, "gene_names": [ { "name": "LOC615581", "type": "recommended", "evidence": [ { "id": "A0AAA9SFS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" } ] } ], "protein_names": [ { "name": "Nuclear RNA export factor Tap RNA-binding domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SFS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC615581", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFS8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10662:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10662:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLSILEHTDKVNSLQRRARSSGIYRRQYAYWSEPVTSQQQEDKDSKESDAHMDIQGRYAPYAIPSHHWRSSFQRKDQMHVNMETDQKPPERTMKTNRQDETLGSWFKIIIPFGTKYDEKWLMNLIQKKCSVPFTAVEFHYEKMQAQFFVENANVACALKNVSGKICNEDNEKISIFVEPCDAPESVQKTLTSEKLEQIKFPGDLITRGIGMTWNRRNSMAASLHVYPGIRPMLSSLYLSNKKPYLVHGLSTIMEIASTTENLNLSNTEVKIAGEMDKGHQLEPEGVCADRSAVCTTFRDKSTNMRSSSALSLHPYVSLISPLLPPLPFCLYSPPYLLSLQTGFEVPVPVALQKGVRTVWLGATQRKGNGGGGSRKGWRGQSPSWSIHRVVTRALEC", "length": 397, "header": "tr|A0AAA9SFS8-1|A0AAA9SFS8_BOVIN Isoform 1 of Nuclear RNA export factor Tap RNA-binding domain-containing protein OS=Bos taurus OX=9913 GN=LOC615581 PE=3 SV=1 CANONICAL=A0AAA9SFS8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8/entry#A0AAA9SFS8-1", "sequence": { "sequence": "MLLSILEHTDKVNSLQRRARSSGIYRRQYAYWSEPVTSQQQEDKDSKESDAHMDIQGRYAPYAIPSHHWRSSFQRKDQMHVNMETDQKPPERTMKTNRQDETLGSWFKIIIPFGTKYDEKWLMNLIQKKCSVPFTAVEFHYEKMQAQFFVENANVACALKNVSGKICNEDNEKISIFVEPCDAPESVQKTLTSEKLEQIKFPGDLITRGIGMTWNRRNSMAASLHVYPGIRPMLSSLYLSNKKPYLVHGLSTIMEIASTTENLNLSNTEVKIAGEMDKGHQLEPEGVCADRSAVCTTFRDKSTNMRSSSALSLHPYVSLISPLLPPLPFCLYSPPYLLSLQTGFEVPVPVALQKGVRTVWLGATQRKGNGGGGSRKGWRGQSPSWSIHRVVTRALEC", "length": 397, "header": "tr|A0AAA9SFS8-1|A0AAA9SFS8_BOVIN Isoform 1 of Nuclear RNA export factor Tap RNA-binding domain-containing protein OS=Bos taurus OX=9913 GN=LOC615581 PE=3 SV=1 CANONICAL=A0AAA9SFS8-1" }, "locus": { "chromosome": "NKLS02001178.1", "start_pos": 10654, "end_pos": 7655, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106065.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106065.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082730.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" }, { "id": "PF24048", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24048" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NXF1/2/3/5-like leucine-rich repeat", "eco_id": "ECO_0000259", "start_pos": 195, "end_pos": 307, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS8" }, { "id": "PF09162", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09162" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear RNA export factor Tap RNA-binding", "eco_id": "ECO_0000259", "start_pos": 106, "end_pos": 184, "start_aa": "Trp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 264, "end_pos": 266 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFT5-1", "uniprot_ac": "A0AAA9SFT5", "uniprot_id": "A0AAA9SFT5_BOVIN", "mass": { "chemical_mass": 35702.0, "monoisotopic_mass": 35702.0 }, "refseq": { "ac": "NP_001377645", "name": "olfactory receptor family 6 subfamily C member 1N", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377645" }, "gene_names": [ { "name": "OR6C1N", "type": "recommended", "evidence": [ { "id": "A0AAA9SFT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5" } ] }, { "name": "OR6C1N", "type": "synonym", "evidence": [ { "id": "NP_001377645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377645" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SFT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 6 subfamily C member 1N", "type": "synonym", "evidence": [ { "id": "NP_001377645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377645" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377645" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C1N", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5", "locus": { "chromosome": "5", "start_pos": 58854800, "end_pos": 58855738, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065118", "url": "https://www.ensembl.org/id/ENSBTAG00000065118" } ] } } ], "crossref": [ { "id": "A0AAA9SFT5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100847492", "url": "https://www.ncbi.nlm.nih.gov/gene/100847492", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847492", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847492", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377645", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNYTEITEFILLGLSDDPQLQVVSFIFLLITYMLSITGNLTIIILTLLDAHLQTPMYFFLRNFSLLEVSFTTVSIPRFLATIITGDKTIPFNDCMAQLFFFIFLGVTEFYLLAAMSYDRYIAICKPLHYLTIMNHKVCTLLVLASWLASFLIIFPLVMLFLQLDYCKSNVIDHFSCDYFPLLYLSCSDTKFLEIVGFSCAVFILLFTLALIILSYTYIIRTILRIPSTTQRTKAFSTCSSHMIVISISYGSCIFMYMNPSAKDRVSSSKGVAVLNTSIAPMLNPFIYTLRNQQVKRAFMDTARKTIFFSSK", "length": 312, "header": "tr|A0AAA9SFT5-1|A0AAA9SFT5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C1N PE=3 SV=1 CANONICAL=A0AAA9SFT5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5/entry#A0AAA9SFT5-1", "sequence": { "sequence": "MRNYTEITEFILLGLSDDPQLQVVSFIFLLITYMLSITGNLTIIILTLLDAHLQTPMYFFLRNFSLLEVSFTTVSIPRFLATIITGDKTIPFNDCMAQLFFFIFLGVTEFYLLAAMSYDRYIAICKPLHYLTIMNHKVCTLLVLASWLASFLIIFPLVMLFLQLDYCKSNVIDHFSCDYFPLLYLSCSDTKFLEIVGFSCAVFILLFTLALIILSYTYIIRTILRIPSTTQRTKAFSTCSSHMIVISISYGSCIFMYMNPSAKDRVSSSKGVAVLNTSIAPMLNPFIYTLRNQQVKRAFMDTARKTIFFSSK", "length": 312, "header": "tr|A0AAA9SFT5-1|A0AAA9SFT5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C1N PE=3 SV=1 CANONICAL=A0AAA9SFT5-1" }, "locus": { "chromosome": "5", "start_pos": 58855738, "end_pos": 58854803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113118.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113118.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081327.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081327.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100847492", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847492", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFT5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 276, "end_pos": 278 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFW5-1", "uniprot_ac": "A0AAA9SFW5", "uniprot_id": "A0AAA9SFW5_BOVIN", "mass": { "chemical_mass": 65721.0, "monoisotopic_mass": 65721.0 }, "refseq": { "ac": "XP_059747130", "name": "proto-oncogene c-Rel isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747130" }, "gene_names": [ { "name": "REL", "type": "recommended", "evidence": [ { "id": "A0AAA9SFW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ] }, { "name": "REL", "type": "synonym", "evidence": [ { "id": "XP_059747130", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747130" } ] } ], "protein_names": [ { "name": "REL proto-onco, NF-kB subunit", "type": "synonym", "evidence": [ { "id": "A0AAA9SFW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5/entry#names_and_taxonomy" } ] }, { "name": "proto-oncogene c-Rel isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059747130", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747130" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5", "locus": { "chromosome": "11", "start_pos": 43662860, "end_pos": 43625348, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015386", "url": "https://www.ensembl.org/id/ENSBTAG00000015386" } ] } } ], "crossref": [ { "id": "A0AAA9SFW5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015386", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015386", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01177", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01177", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07933", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07933", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509135", "url": "https://www.ncbi.nlm.nih.gov/gene/509135", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509135", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509135", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MJH6", "url": "https://www.orthodb.org/?gene=F1MJH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24169:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24169:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00554", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00554", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1169091", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059747130", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747130", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJH6", "url": "https://www.uniprot.org/uniprotkb/F1MJH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJH6-1", "url": "https://www.uniprot.org/uniprotkb/F1MJH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKLIGGFNPCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKDAVISRVRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGVFSQADVHRQVAIVFKTPPYCKAIIEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDTYGNKAKKQKTTLLFHKLWQDCGVNFPERPRPSPLGPTGEGRFIKKEPNLFSHGAVLPETSRPVSSQAESYYSSSASISSTLSHPASAMLPMGTQSSSGWSSVAHPTSRSVNTNSLSSFSTGTLSSNSQVIPPFLEMSDLNVSNACIYNNTNDIGRMEASSVSPADLYSISDASMLPNCPVNMITPSNDSMRETDNPRLVSMNLENPSCNSVLDPRDLRQLHQMSPSSMSTVTSSSTTAYVAQSEAFEGSDFNCADNSMINEAGPSNSTNANSHGFGPNSQYSGIGAMQNEQLSDSFAFEFFKVNL", "length": 593, "header": "tr|A0AAA9SFW5-1|A0AAA9SFW5_BOVIN Isoform 1 of REL proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=REL PE=4 SV=1 CANONICAL=A0AAA9SFW5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5/entry#A0AAA9SFW5-1", "sequence": { "sequence": "MLKLIGGFNPCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKDAVISRVRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGVFSQADVHRQVAIVFKTPPYCKAIIEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDTYGNKAKKQKTTLLFHKLWQDCGVNFPERPRPSPLGPTGEGRFIKKEPNLFSHGAVLPETSRPVSSQAESYYSSSASISSTLSHPASAMLPMGTQSSSGWSSVAHPTSRSVNTNSLSSFSTGTLSSNSQVIPPFLEMSDLNVSNACIYNNTNDIGRMEASSVSPADLYSISDASMLPNCPVNMITPSNDSMRETDNPRLVSMNLENPSCNSVLDPRDLRQLHQMSPSSMSTVTSSSTTAYVAQSEAFEGSDFNCADNSMINEAGPSNSTNANSHGFGPNSQYSGIGAMQNEQLSDSFAFEFFKVNL", "length": 593, "header": "tr|A0AAA9SFW5-1|A0AAA9SFW5_BOVIN Isoform 1 of REL proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=REL PE=4 SV=1 CANONICAL=A0AAA9SFW5-1" }, "locus": { "chromosome": "11", "start_pos": 43662803, "end_pos": 43628362, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087865.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087865.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081361.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081361.1" } ] } }, { "isoform_ac": "F1MJH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5/entry#F1MJH6-1", "sequence": { "sequence": "MASGGFNPCIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQILNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKDAVISRVRAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGVFSQADVHRQVAIVFKTPPYCKAIIEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDTYGNKAKKQKTTLLFHKLWQDCGVNFPERPRPSPLGPTGEGRFIKKEPNLFSHGAVLPETSRPVSSQAESYYSSSASISSTLSHPASAMLPMGTQSSSGWSSVAHPTSRSVNTNSLSSFSTGTLSSNSQVIPPFLEMSDLNVSNACIYNNTNDIGRMEASSVSPADLYSISDASMLPNCPVNMITPSNDSMRETDNPRLVSMNLENPSCNSVLDPRDLRQLHQMSPSSMSTVTSSSTTAYVAQSEAFEGSDFNCADNSMINEAGPSNSTNANSHGFGPNSQYSGIGAMQNEQLSDSFAFEFFKVNL", "length": 591, "header": "tr|F1MJH6-1|F1MJH6_BOVIN Computationally mapped isoform of REL proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=REL PE=4 SV=4 CANONICAL=A0AAA9SFW5-1" }, "locus": { "chromosome": "11", "start_pos": 43662803, "end_pos": 43625547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020447.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020447.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020447.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020447.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509135", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509135", "resource": "KEGG Pathway" }, { "id": "R-BTA-1169091", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "resource": "Reactome", "description": "Activation of NF-kappaB in B cells" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "negative regulation of interferon-beta production", "id": "GO:0032688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032688", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "canonical NF-kappaB signal transduction", "id": "GO:0007249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "non-canonical NF-kappaB signal transduction", "id": "GO:0038061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038061", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "regulation of multicellular organismal process", "id": "GO:0051239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051239", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW5" }, { "id": "PS50254", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50254" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RHD", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 184, "start_aa": "Gly", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 475, "end_pos": 477 }, { "start_pos": 554, "end_pos": 556 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFW7-1", "uniprot_ac": "A0AAA9SFW7", "uniprot_id": "A0AAA9SFW7_BOVIN", "mass": { "chemical_mass": 11682.0, "monoisotopic_mass": 11682.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SFW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFW7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFW7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GNKVEQSPTLSVQEGNSTFITCTYTDGNSNYFPWYKQEPGKGPQLLIAIHSNKAKEEDQRLTVLLNKTAKRLSLHIATTEAGDSAVYFCAASTQCFPGIFCLYSNL", "length": 106, "header": "tr|A0AAA9SFW7-1|A0AAA9SFW7_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SFW7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7/entry#A0AAA9SFW7-1", "sequence": { "sequence": "GNKVEQSPTLSVQEGNSTFITCTYTDGNSNYFPWYKQEPGKGPQLLIAIHSNKAKEEDQRLTVLLNKTAKRLSLHIATTEAGDSAVYFCAASTQCFPGIFCLYSNL", "length": 106, "header": "tr|A0AAA9SFW7-1|A0AAA9SFW7_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SFW7-1" }, "locus": { "chromosome": "10", "start_pos": 22752696, "end_pos": 22752379, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082524.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082524.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW7" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 92, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFW8-1", "uniprot_ac": "A0AAA9SFW8", "uniprot_id": "A0AAA9SFW8_BOVIN", "mass": { "chemical_mass": 74980.0, "monoisotopic_mass": 74980.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF746", "type": "recommended", "evidence": [ { "id": "A0AAA9SFW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ] } ], "protein_names": [ { "name": "Zinc finger protein 746", "type": "recommended", "evidence": [ { "id": "A0AAA9SFW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8#function" }, { "database": "UniProtKB", "id": "ARBA00059214", "url": "https://www.uniprot.org/uniprotkb/ARBA00059214#function" }, { "database": "UniProtKB", "id": "A0AAA9T195", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T195#function" }, { "database": "UniProtKB", "id": "A0AAF6YZP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZP0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF746", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8", "locus": { "chromosome": "4", "start_pos": 112486138, "end_pos": 112509045, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031106", "url": "https://www.ensembl.org/id/ENSBTAG00000031106" } ] } } ], "crossref": [ { "id": "A0AAA9SFW8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521998", "url": "https://www.ncbi.nlm.nih.gov/gene/521998", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T195", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T195", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T195-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T195-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZP0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVPFDDVAVYFSEQEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGESGYPTPHSQVFLGQSAPLKVKRRTGGHTRKAKRVKGRPCWAGGLRQSVRSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL", "length": 693, "header": "tr|A0AAA9SFW8-1|A0AAA9SFW8_BOVIN Isoform 1 of Zinc finger protein 746 OS=Bos taurus OX=9913 GN=ZNF746 PE=3 SV=1 CANONICAL=A0AAA9SFW8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8/entry#A0AAA9SFW8-1", "sequence": { "sequence": "MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVPFDDVAVYFSEQEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGESGYPTPHSQVFLGQSAPLKVKRRTGGHTRKAKRVKGRPCWAGGLRQSVRSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL", "length": 693, "header": "tr|A0AAA9SFW8-1|A0AAA9SFW8_BOVIN Isoform 1 of Zinc finger protein 746 OS=Bos taurus OX=9913 GN=ZNF746 PE=3 SV=1 CANONICAL=A0AAA9SFW8-1" }, "locus": { "chromosome": "4", "start_pos": 112508081, "end_pos": 112487743, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095620.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095620.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084267.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084267.1" } ] } }, { "isoform_ac": "A0AAA9T195-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8/entry#A0AAA9T195-1", "sequence": { "sequence": "MGPVCCEQIQHCLQRQRREISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL", "length": 641, "header": "tr|A0AAA9T195-1|A0AAA9T195_BOVIN Computationally mapped isoform of Zinc finger protein 746 OS=Bos taurus OX=9913 GN=ZNF746 PE=3 SV=1 CANONICAL=A0AAA9SFW8-1" }, "locus": { "chromosome": "4", "start_pos": 112505337, "end_pos": 112487743, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124925.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124925.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091465.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091465.1" } ] } }, { "isoform_ac": "A0AAF6YZP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8/entry#A0AAF6YZP0-1", "sequence": { "sequence": "MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVPFDDVAVYFSEQEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL", "length": 643, "header": "tr|A0AAF6YZP0-1|A0AAF6YZP0_BOVIN Computationally mapped isoform of Zinc finger protein 746 OS=Bos taurus OX=9913 GN=ZNF746 PE=3 SV=1 CANONICAL=A0AAA9SFW8-1" }, "locus": { "chromosome": "4", "start_pos": 112508081, "end_pos": 112487743, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018668.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018668.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018668.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018668.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 425, "start_aa": "Thr", "end_pos": 425, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr425", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 688, "start_aa": "Thr", "end_pos": 688, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr688", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 517, "end_pos": 544, "start_aa": "Phe", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW8" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 109, "end_pos": 180, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 425, 688 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 305, "end_pos": 307 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFY0-1", "uniprot_ac": "A0AAA9SFY0", "uniprot_id": "A0AAA9SFY0_BOVIN", "mass": { "chemical_mass": 53153.0, "monoisotopic_mass": 53153.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SFY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SFY0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14224:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14224:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SFY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVHNPPRLAILAAIGLLRDEPLAISTLEFLPTELYPPLFMAAVFGRHRETLKAMVPAWPFARLPLGSLMQKPHQGTLQAVLEGLDVLLAQKVHPRRGKLRVLDLRNTGQDFWNMWSGGKGHMPSSSLLVPVAEDMSRKRHPLTPLEVYIELCLTKKPLEKFLTYLFRWVEQRKASIHLCCKKMKIISMSKENMKEVLRMVKLDCVQMVKLSFTQKLSTLAQFAPLLGQMSNVQSLILSRIRGSAVEEQDHQDLLQFTSQILQLRNLRNLSMEAPFFLEGCLDQMLRCLKTPLDNISITNCLLTESDLTHLSWCPKICQLKGLNLSGVTLTDFNPKLLQVLLEKVAGTLEELDLNLCGITDVHLMGFLPALSCCSQLRVLTMCGNLISMAVLESVLRHTDRLPDLNLELYPAPRESYSSLGVLHRERFAQIKAKLRVILTYLERPRKIWVSPSPCPYCGDDMCGHLSPNT", "length": 470, "header": "tr|A0AAA9SFY0-1|A0AAA9SFY0_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SFY0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0/entry#A0AAA9SFY0-1", "sequence": { "sequence": "MSVHNPPRLAILAAIGLLRDEPLAISTLEFLPTELYPPLFMAAVFGRHRETLKAMVPAWPFARLPLGSLMQKPHQGTLQAVLEGLDVLLAQKVHPRRGKLRVLDLRNTGQDFWNMWSGGKGHMPSSSLLVPVAEDMSRKRHPLTPLEVYIELCLTKKPLEKFLTYLFRWVEQRKASIHLCCKKMKIISMSKENMKEVLRMVKLDCVQMVKLSFTQKLSTLAQFAPLLGQMSNVQSLILSRIRGSAVEEQDHQDLLQFTSQILQLRNLRNLSMEAPFFLEGCLDQMLRCLKTPLDNISITNCLLTESDLTHLSWCPKICQLKGLNLSGVTLTDFNPKLLQVLLEKVAGTLEELDLNLCGITDVHLMGFLPALSCCSQLRVLTMCGNLISMAVLESVLRHTDRLPDLNLELYPAPRESYSSLGVLHRERFAQIKAKLRVILTYLERPRKIWVSPSPCPYCGDDMCGHLSPNT", "length": 470, "header": "tr|A0AAA9SFY0-1|A0AAA9SFY0_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SFY0-1" }, "locus": { "chromosome": "29", "start_pos": 5556886, "end_pos": 5554155, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090730.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090730.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085086.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0" } ], "pmid": "" }, { "name": "negative regulation of cell differentiation", "id": "GO:0045596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045596", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 269, "end_pos": 271 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 324, "end_pos": 326 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFY5-1", "uniprot_ac": "A0AAA9SFY5", "uniprot_id": "A0AAA9SFY5_BOVIN", "mass": { "chemical_mass": 33970.0, "monoisotopic_mass": 33970.0 }, "refseq": { "ac": "NP_001192633", "name": "RWD domain-containing protein 2A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192633" }, "gene_names": [ { "name": "RWDD2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5" } ] }, { "name": "RWDD2A", "type": "synonym", "evidence": [ { "id": "NP_001192633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192633" } ] } ], "protein_names": [ { "name": "RWD domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5/entry#names_and_taxonomy" } ] }, { "name": "RWD domain-containing protein 2A", "type": "synonym", "evidence": [ { "id": "NP_001192633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192633" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RWDD2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5", "locus": { "chromosome": "9", "start_pos": 23121072, "end_pos": 23115935, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015911", "url": "https://www.ensembl.org/id/ENSBTAG00000015911" } ] } } ], "crossref": [ { "id": "A0AAA9SFY5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015911", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015911", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23829", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23829", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd24163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd24163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539733", "url": "https://www.ncbi.nlm.nih.gov/gene/539733", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539733", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539733", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BBJ6", "url": "https://www.orthodb.org/?gene=E1BBJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15955", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15955", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15955:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15955:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192633", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBJ6", "url": "https://www.uniprot.org/uniprotkb/E1BBJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBJ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASMKECLQLQLLEMEMLFSMFPNQGEVKLEDVNALTNIKRYLDGIREALPPKIEFVITLQIEEPKVKIDLQVTMPHSYPYVALQMFARSPELDRQQQLLLNKGLTSYIGTFDPGELCVCAAIQWLQDNSASYFLNRKLVDEPSTQAKPVKNTFLRMWIYSHHIYQQDLRKKILEVGKRLDVTGFCMTGKPGIICVEGFKEHCEEFWHTIRYPNWKHISCKHAESMETEGDGQDLRLFHSFEELLLEAHGDYGLRNDYHMNLGQFLEFLKKHKSEHVFQILFGIESKSSDS", "length": 292, "header": "tr|A0AAA9SFY5-1|A0AAA9SFY5_BOVIN Isoform 1 of RWD domain-containing protein OS=Bos taurus OX=9913 GN=RWDD2A PE=4 SV=1 CANONICAL=A0AAA9SFY5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5/entry#A0AAA9SFY5-1", "sequence": { "sequence": "MSASMKECLQLQLLEMEMLFSMFPNQGEVKLEDVNALTNIKRYLDGIREALPPKIEFVITLQIEEPKVKIDLQVTMPHSYPYVALQMFARSPELDRQQQLLLNKGLTSYIGTFDPGELCVCAAIQWLQDNSASYFLNRKLVDEPSTQAKPVKNTFLRMWIYSHHIYQQDLRKKILEVGKRLDVTGFCMTGKPGIICVEGFKEHCEEFWHTIRYPNWKHISCKHAESMETEGDGQDLRLFHSFEELLLEAHGDYGLRNDYHMNLGQFLEFLKKHKSEHVFQILFGIESKSSDS", "length": 292, "header": "tr|A0AAA9SFY5-1|A0AAA9SFY5_BOVIN Isoform 1 of RWD domain-containing protein OS=Bos taurus OX=9913 GN=RWDD2A PE=4 SV=1 CANONICAL=A0AAA9SFY5-1" }, "locus": { "chromosome": "9", "start_pos": 23118926, "end_pos": 23117040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102105.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102105.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081383.1" } ] } }, { "isoform_ac": "E1BBJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5/entry#E1BBJ6-1", "sequence": { "sequence": "MSASMKECLQLQLLEMEMLFSMFPNQGEVKLEDVNALTNIKRYLDGIREALPPKIEFVITLQIEEPKVKIDLQVTMPHSYPYVALQMFARSPELDRQQQLLLNKGLTSYIGTFDPGELCVCAAIQWLQDNSASYFLNRKLVDEPSTQAKPVKNTFLRMWIYSHHIYQQDLRKKILEVGKRLDVTGFCMTGKPGIICVEGFKEHCEEFWHTIRYPNWKHISCKHAESMETEGDGQDLRLFHSFEELLLEAHGDYGLRNDYHMNLGQFLEFLKKHKKALILFSHRVMSNSSQPHGLQHARIPCPLPSPGVCPSSCPFHR", "length": 317, "header": "tr|E1BBJ6-1|E1BBJ6_BOVIN Computationally mapped isoform of RWD domain-containing protein OS=Bos taurus OX=9913 GN=RWDD2A PE=4 SV=3 CANONICAL=A0AAA9SFY5-1" }, "locus": { "chromosome": "9", "start_pos": 23121031, "end_pos": 23117040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021159.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021159.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021159.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021159.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539733", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539733", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFY5" }, { "id": "PS50908", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RWD", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 134, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG11-1", "uniprot_ac": "A0AAA9SG11", "uniprot_id": "A0AAA9SG11_BOVIN", "mass": { "chemical_mass": 35928.0, "monoisotopic_mass": 35928.0 }, "refseq": {}, "gene_names": [ { "name": "OR6C282", "type": "recommended", "evidence": [ { "id": "A0AAA9SG11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SG11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C282", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11", "locus": { "chromosome": "5", "start_pos": 58640018, "end_pos": 58618683, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069047", "url": "https://www.ensembl.org/id/ENSBTAG00000069047" } ] } } ], "crossref": [ { "id": "A0AAA9SG11", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG11", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNHTRPTEFILLGLSDDPELQIVIFLFLIITYILSVTGNLTIIILTLVDSHLQTPMYFFLRNFSILEISFTTVCIPRFLGTIITRNKTISYNDCTAQLFFFIFLGITEFYLLTAMSYDRYVAICKPLHYTTIMNNRVCVLLVFCAWLAGFLNIFPPVILFLQLDYCGSNIIDHFTCDYFPLLQLSCSDIWLLEVIGFYSAIEILLFTLALIILSYMFIIKTVLRLPSASQRKKAFSACSSHMIVIFISYGSCIFVYINPSAKEKTSLMKGVAILDTSVAPMMNLFIYTLRNQQVQAFKDTIQKFIFFSSKCN", "length": 313, "header": "tr|A0AAA9SG11-1|A0AAA9SG11_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C282 PE=3 SV=1 CANONICAL=A0AAA9SG11-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11/entry#A0AAA9SG11-1", "sequence": { "sequence": "MKNHTRPTEFILLGLSDDPELQIVIFLFLIITYILSVTGNLTIIILTLVDSHLQTPMYFFLRNFSILEISFTTVCIPRFLGTIITRNKTISYNDCTAQLFFFIFLGITEFYLLTAMSYDRYVAICKPLHYTTIMNNRVCVLLVFCAWLAGFLNIFPPVILFLQLDYCGSNIIDHFTCDYFPLLQLSCSDIWLLEVIGFYSAIEILLFTLALIILSYMFIIKTVLRLPSASQRKKAFSACSSHMIVIFISYGSCIFVYINPSAKEKTSLMKGVAILDTSVAPMMNLFIYTLRNQQVQAFKDTIQKFIFFSSKCN", "length": 313, "header": "tr|A0AAA9SG11-1|A0AAA9SG11_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C282 PE=3 SV=1 CANONICAL=A0AAA9SG11-1" }, "locus": { "chromosome": "5", "start_pos": 58640015, "end_pos": 58618683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108482.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108482.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084307.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG11" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG12-1", "uniprot_ac": "A0AAA9SG12", "uniprot_id": "A0AAA9SG12_BOVIN", "mass": { "chemical_mass": 34574.0, "monoisotopic_mass": 34574.0 }, "refseq": { "ac": "NP_001376816", "name": "olfactory receptor family 4 subfamily A member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816" }, "gene_names": [ { "name": "OR4A2", "type": "recommended", "evidence": [ { "id": "A0AAA9SG12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12" } ] }, { "name": "OR4A15", "type": "synonym", "evidence": [ { "id": "NP_001376816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816" } ] }, { "name": "OR4A2", "type": "synonym", "evidence": [ { "id": "NP_001376816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SG12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 4 subfamily A member 2", "type": "synonym", "evidence": [ { "id": "NP_001376816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816" } ] }, { "name": "olfactory receptor, family 4, subfamily A, member 15", "type": "synonym", "evidence": [ { "id": "NP_001376816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12", "locus": { "chromosome": "15", "start_pos": 84155994, "end_pos": 84155077, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057798", "url": "https://www.ensembl.org/id/ENSBTAG00000057798" } ] } } ], "crossref": [ { "id": "A0AAA9SG12", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG12", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511653", "url": "https://www.ncbi.nlm.nih.gov/gene/511653", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511653", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511653", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376816", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQRRNVTEFVLLGLTQSVQGQKILFVVFLLIYIVTMVGNLLIVLTVVFSPSLDVPMYFFLGYLSFMDAVYSTTVTPNMIIDLLYVKKTISFQACMTQLFIGHLFGGAEILLLVVMAYDRYVAICKPLHYLTIMNQRVCVMLLLLAWVGGFLHAVVQLLFVYNLPFCGPNVIDHFICDMYPLLKLACTDTYIIGLTVVANDGAICVIIFMLLLISYGIILHSLKNLSQEGRRKALSTCGSHITVVILFFVPCIFMYVRPPSTLPTDKSLTVFYTIITPMLNPLIYTLRNAEMKNAMKKLWTNKRK", "length": 305, "header": "tr|A0AAA9SG12-1|A0AAA9SG12_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A2 PE=3 SV=1 CANONICAL=A0AAA9SG12-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12/entry#A0AAA9SG12-1", "sequence": { "sequence": "MEQRRNVTEFVLLGLTQSVQGQKILFVVFLLIYIVTMVGNLLIVLTVVFSPSLDVPMYFFLGYLSFMDAVYSTTVTPNMIIDLLYVKKTISFQACMTQLFIGHLFGGAEILLLVVMAYDRYVAICKPLHYLTIMNQRVCVMLLLLAWVGGFLHAVVQLLFVYNLPFCGPNVIDHFICDMYPLLKLACTDTYIIGLTVVANDGAICVIIFMLLLISYGIILHSLKNLSQEGRRKALSTCGSHITVVILFFVPCIFMYVRPPSTLPTDKSLTVFYTIITPMLNPLIYTLRNAEMKNAMKKLWTNKRK", "length": 305, "header": "tr|A0AAA9SG12-1|A0AAA9SG12_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A2 PE=3 SV=1 CANONICAL=A0AAA9SG12-1" }, "locus": { "chromosome": "15", "start_pos": 84155991, "end_pos": 84155077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100929.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100929.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082591.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082591.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511653", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511653", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG12" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 285, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG28-1", "uniprot_ac": "A0AAA9SG28", "uniprot_id": "A0AAA9SG28_BOVIN", "mass": { "chemical_mass": 33727.0, "monoisotopic_mass": 33727.0 }, "refseq": {}, "gene_names": [ { "name": "TASL", "type": "recommended", "evidence": [ { "id": "A0AAA9SG28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ] } ], "protein_names": [ { "name": "TLR adaptor interacting with endolysosomal SLC15A4", "type": "synonym", "evidence": [ { "id": "A0AAA9SG28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TASL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28", "locus": { "chromosome": "X", "start_pos": 113023102, "end_pos": 113007421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058370", "url": "https://www.ensembl.org/id/ENSBTAG00000058370" } ] } } ], "crossref": [ { "id": "A0AAA9SG28", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG28", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR027869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MFHDSSP", "url": "https://omabrowser.org/oma/group/MFHDSSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14889", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14889", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14889:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14889:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSEGYLSGLAYRNDIQWSYPSSNEQVAEEKEEEMEATAAASLSYSSVDETQVQNLYVSCKSSGKVISSVYSRESQHSRNPRITVLQTNPNPVYESPNLAAVELYRDTSRETYLVPPSCKSICKNYNDLQIAGGQVMAINSATTDFPSEGSFQYGPLLKSSEIPLSMEDSMFTQPSDLPPTPIQRYSSYWRITSIKEKNSLQMQKPISNAVLNEYLEQKLVELYKQYFMDTGFHDSSPTQILASELIMTNVDQISIQVSIEKNLEISKARDIVINRLLQYGSTEISTPSLHISQYSNVNP", "length": 300, "header": "tr|A0AAA9SG28-1|A0AAA9SG28_BOVIN Isoform 1 of TLR adaptor interacting with endolysosomal SLC15A4 OS=Bos taurus OX=9913 GN=TASL PE=4 SV=1 CANONICAL=A0AAA9SG28-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28/entry#A0AAA9SG28-1", "sequence": { "sequence": "MLSEGYLSGLAYRNDIQWSYPSSNEQVAEEKEEEMEATAAASLSYSSVDETQVQNLYVSCKSSGKVISSVYSRESQHSRNPRITVLQTNPNPVYESPNLAAVELYRDTSRETYLVPPSCKSICKNYNDLQIAGGQVMAINSATTDFPSEGSFQYGPLLKSSEIPLSMEDSMFTQPSDLPPTPIQRYSSYWRITSIKEKNSLQMQKPISNAVLNEYLEQKLVELYKQYFMDTGFHDSSPTQILASELIMTNVDQISIQVSIEKNLEISKARDIVINRLLQYGSTEISTPSLHISQYSNVNP", "length": 300, "header": "tr|A0AAA9SG28-1|A0AAA9SG28_BOVIN Isoform 1 of TLR adaptor interacting with endolysosomal SLC15A4 OS=Bos taurus OX=9913 GN=TASL PE=4 SV=1 CANONICAL=A0AAA9SG28-1" }, "locus": { "chromosome": "X", "start_pos": 113019959, "end_pos": 113019060, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103895.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103895.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082834.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RS25-1", "protein_name": "TLR adaptor interacting with endolysosomal SLC15A4", "gene_name": "CXorf21", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSEGYLYRIAYLCEDSELCTNQAVEEVVYEMRSINCSSRDEAQVKSLLQRCRSAGKCISAVHSRGSKHSRRQKDNLQQSVQNPLPEGQTSPTMDVCEGLVRKDTYLVPSSCKSICKNYNDLHIAGDCVVPISSVATDFTCDSGIGPFLESSEIPPPMESVRVPPSETGRKQAQGFSSCWRVASLVPHQQPLSDSALNDYLEQKLMELYKQYIMDSTVNRASPTQILASELIMTNVDQISTQISRERKMETTKAKDIVISRFLQIASEQIFSEISTPSLHISQYSNTNA", "length": 289 }, "evidence": [ { "id": "A0AAA9SG28", "url": "https://omabrowser.org/oma/group/A0AAA9SG28/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZRK2-1", "protein_name": "TLR adaptor interacting with endolysosomal SLC15A4", "gene_name": "Tasl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSEGYLSGLTYWNDIHWNCASYNEPVAGDQGEETSSVAALSYSSVDETQVQSVYVSCKSSGKFISSVHARASQHSRSQSRTVLQANSNPVFESPTLAAVGICRDVIRETYLVPPSCKSICKNYNDLHIAGGQVMAINSVMADFPSESSFEDGPLLKSSEISLSMEDSISTQFTELPLKPIQRYSSYWRITSIKEKNSLQMQKPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQILASEFIMTNVDQISLQVSKEKNLDTSKVKDIVISHLLQLVSSEISTPSLHISQYSDITP", "length": 298 }, "evidence": [ { "id": "A0AAA9SG28", "url": "https://omabrowser.org/oma/group/A0AAA9SG28/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SPV1-1", "protein_name": "TLR adaptor interacting with endolysosomal SLC15A4", "gene_name": "TASL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSEGYLSGLAYQNDIYWNCTSCNEQVVEEKEETEATAATALYYSPVDKTQVRNLYVSCKSSDKFISSVHSRESHPSRNPMITVLQANPNPVFESPNLATVELYRDPSRETYLVPPSCKSICKNYNDLHIAGGQVMALNSVTTDFASEGSFEHGPLLKSSEIPLTMEDSISTQPSDLPPKPIQRYSSYWRITSVKEKSSLQMQKPISNAVLNEYLEQKVVELYKQYIMDNMFHDSSPTQILASELIMTSVDQISIQVSREKNLETSKARDIVINRLLQLVSTEISTPSLHISQYSNVNP", "length": 299 }, "evidence": [ { "id": "A0AAA9SG28", "url": "https://omabrowser.org/oma/group/A0AAA9SG28/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D3J9-1", "protein_name": "TLR adapter interacting with SLC15A4 on the lysosome", "gene_name": "Tasl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSEGYLSGLTYWNDIHWNCASYNEPVAGDQGKETSSVAALSYSSVDETQVQSLYVSCKSSGKFISSVHARASQHSRSQSRTVLQANSNPVFESPTLAAVGICRDVIRETYLVPPSCKSICKNYNDLHIAGGQVMAINSVMANFPSESSFEDGPLLKSSEISLSMEDSTSTQLTELPLKPIQRYSSYWRITSIKEKSSLQMQKPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQILASEFIMTNVDQISLQVSKEKNLDTSKVKDIVISHLLQLVSSEISTPSLHISQYSNITP", "length": 298 }, "evidence": [ { "id": "A0AAA9SG28", "url": "https://omabrowser.org/oma/group/A0AAA9SG28/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HAI6-1", "protein_name": "TLR adapter interacting with SLC15A4 on the lysosome", "gene_name": "TASL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSEGYLSGLEYWNDIHWSCASYNEQVAGEKEEETNSVATLSYSSVDETQVRSLYVSCKSSGKFISSVHSRESQHSRSQRVTVLQTNPNPVFESPNLAAVEICRDASRETYLVPSSCKSICKNYNDLQIAGGQVMAINSVTTDFPSESSFEYGPLLKSSEIPLPMEDSISTQPSDFPQKPIQRYSSYWRITSIKEKSSLQMQNPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQILASELIMTSVDQISLQVSREKNLETSKARDIVFSRLLQLMSTEITEISTPSLHISQYSNVNP", "length": 301 }, "evidence": [ { "id": "A0AAA9SG28", "url": "https://omabrowser.org/oma/group/A0AAA9SG28/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" }, { "name": "endolysosome membrane", "id": "GO:0036020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of toll-like receptor signaling pathway", "id": "GO:0034121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 7 signaling pathway", "id": "GO:0034157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" }, { "name": "regulation of lysosomal lumen pH", "id": "GO:0035751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035751", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 8 signaling pathway", "id": "GO:0034161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG32-1", "uniprot_ac": "A0AAA9SG32", "uniprot_id": "A0AAA9SG32_BOVIN", "mass": { "chemical_mass": 35723.0, "monoisotopic_mass": 35723.0 }, "refseq": { "ac": "XP_005213929", "name": "BTB/POZ domain-containing protein KCTD12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213929" }, "gene_names": [ { "name": "KCTD12", "type": "recommended", "evidence": [ { "id": "A0AAA9SG32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ] }, { "name": "KCTD12", "type": "synonym", "evidence": [ { "id": "XP_005213929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213929" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD12", "type": "synonym", "evidence": [ { "id": "XP_005213929", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213929" } ] }, { "name": "Potassium channel tetramerization domain containing 12", "type": "synonym", "evidence": [ { "id": "A0AAA9SG32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32#function" }, { "database": "UniProtKB", "id": "ARBA00057758", "url": "https://www.uniprot.org/uniprotkb/ARBA00057758#function" }, { "database": "UniProtKB", "id": "G3N3D4", "url": "https://www.uniprot.org/uniprotkb/G3N3D4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32", "locus": { "chromosome": "12", "start_pos": 51993631, "end_pos": 52005793, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001414", "url": "https://www.ensembl.org/id/ENSBTAG00000001414" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001414", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001414", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18397", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18397", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22217", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22217", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616416", "url": "https://www.ncbi.nlm.nih.gov/gene/616416", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049905", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049905", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616416", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616416", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DPDHGMS", "url": "https://omabrowser.org/oma/group/DPDHGMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N3D4", "url": "https://www.orthodb.org/?gene=G3N3D4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213929", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213929", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3D4", "url": "https://www.uniprot.org/uniprotkb/G3N3D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3D4-1", "url": "https://www.uniprot.org/uniprotkb/G3N3D4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALADSTRGLPNGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVQKEGSLGDDLLPLGSAESEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFAGSTDQSEDKIWTSYTEYVFCRE", "length": 326, "header": "tr|A0AAA9SG32-1|A0AAA9SG32_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 12 OS=Bos taurus OX=9913 GN=KCTD12 PE=1 SV=1 CANONICAL=A0AAA9SG32-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32/entry#A0AAA9SG32-1", "sequence": { "sequence": "MALADSTRGLPNGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVQKEGSLGDDLLPLGSAESEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFAGSTDQSEDKIWTSYTEYVFCRE", "length": 326, "header": "tr|A0AAA9SG32-1|A0AAA9SG32_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 12 OS=Bos taurus OX=9913 GN=KCTD12 PE=1 SV=1 CANONICAL=A0AAA9SG32-1" }, "locus": { "chromosome": "12", "start_pos": 51998677, "end_pos": 51998634, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096412.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096412.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081429.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081429.1" } ] } }, { "isoform_ac": "G3N3D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32/entry#G3N3D4-1", "sequence": { "sequence": "MALADSTRGLPNGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVQKEGSLGDDLLPLGSAESEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFAGSTDQSEDKIWTSYTELQPQILSASSSSPDPSEREPRRTPPPHVFSVPGPKPTLPSSCPSVWI", "length": 367, "header": "tr|G3N3D4-1|G3N3D4_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 12 OS=Bos taurus OX=9913 GN=KCTD12 PE=1 SV=2 CANONICAL=A0AAA9SG32-1" }, "locus": { "chromosome": "12", "start_pos": 52004884, "end_pos": 52003610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001854.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001854.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056437.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056437.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 46, "start_aa": "Thr", "end_pos": 46, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr46", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616416", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616416", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y7I2-1", "protein_name": "Potassium channel tetramerization domain containing 12", "gene_name": "Kctd12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLPLGYAEPEPQEGASAGAPSPTLDLASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE", "length": 327 }, "evidence": [ { "id": "A0AAA9SG32", "url": "https://omabrowser.org/oma/group/A0AAA9SG32/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6WVG3-1", "protein_name": "BTB/POZ domain-containing protein KCTD12", "gene_name": "Kctd12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALADSARGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFFFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLPLGYAEPEPQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE", "length": 327 }, "evidence": [ { "id": "A0AAA9SG32", "url": "https://omabrowser.org/oma/group/A0AAA9SG32/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96CX2-1", "protein_name": "BTB/POZ domain-containing protein KCTD12", "gene_name": "KCTD12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPSRRGVHKEGSLGDELLPLGYSEPEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE", "length": 325 }, "evidence": [ { "id": "A0AAA9SG32", "url": "https://omabrowser.org/oma/group/A0AAA9SG32/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VDH3-1", "protein_name": "Kctd12-like, isoform A", "gene_name": "Ktl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPEIIELNVGGVSYTTTLATLLQDKSTLLAELFGEGRDSLAKDSKGRYFLDRDGVLFRYILDFLRDKALHLPEGFRERQRLLREAEHFKLTAMLECIRSERDARPPGCITIGYRGSFQFGKDGLADVKFRKLSRILVCGRVAQCREVFGDTLNESRDPDHGGTDRYTSRFFLKHCYIEQAFDNLHDHGYRMAGSCGSGTAGSAAEPKPGVDTEENRWNHYNEFVFIRD", "length": 228 }, "evidence": [ { "id": "A0AAA9SG32", "url": "https://omabrowser.org/oma/group/A0AAA9SG32/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "pmid": "" }, { "name": "regulation of G protein-coupled receptor signaling pathway", "id": "GO:0008277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG32" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 136, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 46 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG56-1", "uniprot_ac": "A0AAA9SG56", "uniprot_id": "A0AAA9SG56_BOVIN", "mass": { "chemical_mass": 35432.0, "monoisotopic_mass": 35432.0 }, "refseq": { "ac": "NP_001377227", "name": "olfactory receptor family 4 subfamily K member 54", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377227" }, "gene_names": [ { "name": "OR4K54", "type": "recommended", "evidence": [ { "id": "A0AAA9SG56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56" } ] }, { "name": "OR4K54", "type": "synonym", "evidence": [ { "id": "NP_001377227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377227" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 4 subfamily K member 54", "type": "synonym", "evidence": [ { "id": "A0AAA9SG56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4K3", "type": "synonym", "evidence": [ { "id": "NP_001377227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377227" } ] }, { "name": "olfactory receptor family 4 subfamily K member 54", "type": "synonym", "evidence": [ { "id": "NP_001377227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377227" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377227" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4K54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56", "locus": { "chromosome": "10", "start_pos": 27679172, "end_pos": 27678234, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068153", "url": "https://www.ensembl.org/id/ENSBTAG00000068153" } ] } } ], "crossref": [ { "id": "A0AAA9SG56", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG56", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781713", "url": "https://www.ncbi.nlm.nih.gov/gene/781713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377227", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEANQSVVSEFVFRGLCDSKDLQKFLFLPFSALYLMTVLGNLFIAFLIITDSHLHPPMYFLLANLSFVDFCLSSVTTPKLITDFLKDNKTISFGGCMSQILFIHFLAGDEMVLLVTMAYDRCVAICKPLHYSRIMDRQKCIWLALISWIIGFVHAISQLAMILDLSFCGPRIVDSFFCDIPEVIKLACMDTHTLRILINADSGVLAVTCFILLLISYTYILVTIHLHSKDGSSKALSTCTSHITVVVLFFGPCIFIYFWPLSITWVDKVLSVFYTVITPLLNPAIYTLRNKEIKNAVKRLISQHKNTKYNF", "length": 312, "header": "tr|A0AAA9SG56-1|A0AAA9SG56_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily K member 54 OS=Bos taurus OX=9913 GN=OR4K54 PE=3 SV=1 CANONICAL=A0AAA9SG56-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56/entry#A0AAA9SG56-1", "sequence": { "sequence": "MEEANQSVVSEFVFRGLCDSKDLQKFLFLPFSALYLMTVLGNLFIAFLIITDSHLHPPMYFLLANLSFVDFCLSSVTTPKLITDFLKDNKTISFGGCMSQILFIHFLAGDEMVLLVTMAYDRCVAICKPLHYSRIMDRQKCIWLALISWIIGFVHAISQLAMILDLSFCGPRIVDSFFCDIPEVIKLACMDTHTLRILINADSGVLAVTCFILLLISYTYILVTIHLHSKDGSSKALSTCTSHITVVVLFFGPCIFIYFWPLSITWVDKVLSVFYTVITPLLNPAIYTLRNKEIKNAVKRLISQHKNTKYNF", "length": 312, "header": "tr|A0AAA9SG56-1|A0AAA9SG56_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily K member 54 OS=Bos taurus OX=9913 GN=OR4K54 PE=3 SV=1 CANONICAL=A0AAA9SG56-1" }, "locus": { "chromosome": "10", "start_pos": 27679169, "end_pos": 27678234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116291.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116291.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084357.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084357.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781713", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG56" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG76-1", "uniprot_ac": "A0AAA9SG76", "uniprot_id": "A0AAA9SG76_BOVIN", "mass": { "chemical_mass": 40576.0, "monoisotopic_mass": 40576.0 }, "refseq": {}, "gene_names": [ { "name": "ACTG1", "type": "recommended", "evidence": [ { "id": "A0AAA9SG76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ] } ], "protein_names": [ { "name": "Actin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SG76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76/entry#names_and_taxonomy" } ] }, { "name": "Actin II", "type": "synonym", "evidence": [ { "id": "A0AAA9SG76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm. Polymerizes into longer and more stable actin filaments compared to ACT1/actin-1. Has ATPase activity. ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi. ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin. Plays an essential role in male gametocyte development in the mosquito midgut, functioning in several processes including male gametocyte egress from host erythrocytes, formation of a beating flagellum and relocalization of ACT1/actin-1 to the cytoplasm. On the basal side of the mosquito midgut epithelium, required for the development of ookinetes into sporogonic oocysts.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76#function" }, { "database": "UniProtKB", "id": "ARBA00056954", "url": "https://www.uniprot.org/uniprotkb/ARBA00056954#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76", "locus": { "chromosome": "19", "start_pos": 51262290, "end_pos": 51259312, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006189", "url": "https://www.ensembl.org/id/ENSBTAG00000006189" } ] } } ], "crossref": [ { "id": "A0AAA9SG76", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG76", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF", "length": 364, "header": "tr|A0AAA9SG76-1|A0AAA9SG76_BOVIN Isoform 1 of Actin-2 OS=Bos taurus OX=9913 GN=ACTG1 PE=3 SV=2 CANONICAL=A0AAA9SG76-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76/entry#A0AAA9SG76-1", "sequence": { "sequence": "MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF", "length": 364, "header": "tr|A0AAA9SG76-1|A0AAA9SG76_BOVIN Isoform 1 of Actin-2 OS=Bos taurus OX=9913 GN=ACTG1 PE=3 SV=2 CANONICAL=A0AAA9SG76-1" }, "locus": { "chromosome": "19", "start_pos": 51261556, "end_pos": 51259957, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114661.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114661.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081483.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081483.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "regulation of focal adhesion assembly", "id": "GO:0051893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "tight junction assembly", "id": "GO:0120192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "positive regulation of wound healing", "id": "GO:0090303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "regulation of stress fiber assembly", "id": "GO:0051492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051492", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "morphogenesis of a polarized epithelium", "id": "GO:0001738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001738", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "protein localization to bicellular tight junction", "id": "GO:1902396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle endocytosis", "id": "GO:1900242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900242", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "regulation of transepithelial transport", "id": "GO:0150111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150111", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "calyx of Held", "id": "GO:0044305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044305", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "myofibril", "id": "GO:0030016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030016", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "filamentous actin", "id": "GO:0031941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "basal body patch", "id": "GO:0120220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120220", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" }, { "name": "profilin binding", "id": "GO:0005522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005522", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG79-1", "uniprot_ac": "A0AAA9SG79", "uniprot_id": "A0AAA9SG79_BOVIN", "mass": { "chemical_mass": 46073.0, "monoisotopic_mass": 46073.0 }, "refseq": { "ac": "XP_024855690", "name": "integral membrane protein GPR180 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855690" }, "gene_names": [ { "name": "GPR180", "type": "recommended", "evidence": [ { "id": "A0AAA9SG79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" } ] }, { "name": "GPR180", "type": "synonym", "evidence": [ { "id": "XP_024855690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855690" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 180", "type": "synonym", "evidence": [ { "id": "A0AAA9SG79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79/entry#names_and_taxonomy" } ] }, { "name": "integral membrane protein GPR180 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024855690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855690" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR180", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79", "locus": { "chromosome": "12", "start_pos": 69124784, "end_pos": 69099238, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005310", "url": "https://www.ensembl.org/id/ENSBTAG00000005310" } ] } } ], "crossref": [ { "id": "A0AAA9SG79", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG79", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005310", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005310", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "537630", "url": "https://www.ncbi.nlm.nih.gov/gene/537630", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N5D2", "url": "https://www.orthodb.org/?gene=F1N5D2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23252:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23252:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21870", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21870", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024855690", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5D2", "url": "https://www.uniprot.org/uniprotkb/F1N5D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5D2-1", "url": "https://www.uniprot.org/uniprotkb/F1N5D2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGLRLLAVALTCCWWPPGSQGKTLRGSFSSAAARDAQGQSIGHFEFHGDHALLCVRINNIAVAVGKEAKLYLFQAQEWLKLQEGGPEYSCSEKLSKAQLTMAVNQTEHNLTVSQIPYPQKWHVFYADKYTCREGGEESQMEDVPFEMMLLNPDAEGNPFDHFSAGESGLHEFFFLLVLVYFVIACIYAQSLWQAIKKGGPMHMVLKVLTTALLLQAGSAFANYIHFSSYSKDGIGVPFMGSLAEFFDIASQIQMLYLLLSLCMGWTIVRMKKSQSRPLQWDSTPASTGIAVFMVITQSILLLWEQFEETSSHSHHSHHSLAGILLIVLRICLALSLGCGLYQIITVERSTLKREFYITFAKVWVCLENDFFALSTSFCITGKAASCGFCAIQVLRAFLSFLMTTKEIRSLQ", "length": 412, "header": "tr|A0AAA9SG79-1|A0AAA9SG79_BOVIN Isoform 1 of G protein-coupled receptor 180 OS=Bos taurus OX=9913 GN=GPR180 PE=4 SV=1 CANONICAL=A0AAA9SG79-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79/entry#A0AAA9SG79-1", "sequence": { "sequence": "MRGLRLLAVALTCCWWPPGSQGKTLRGSFSSAAARDAQGQSIGHFEFHGDHALLCVRINNIAVAVGKEAKLYLFQAQEWLKLQEGGPEYSCSEKLSKAQLTMAVNQTEHNLTVSQIPYPQKWHVFYADKYTCREGGEESQMEDVPFEMMLLNPDAEGNPFDHFSAGESGLHEFFFLLVLVYFVIACIYAQSLWQAIKKGGPMHMVLKVLTTALLLQAGSAFANYIHFSSYSKDGIGVPFMGSLAEFFDIASQIQMLYLLLSLCMGWTIVRMKKSQSRPLQWDSTPASTGIAVFMVITQSILLLWEQFEETSSHSHHSHHSLAGILLIVLRICLALSLGCGLYQIITVERSTLKREFYITFAKVWVCLENDFFALSTSFCITGKAASCGFCAIQVLRAFLSFLMTTKEIRSLQ", "length": 412, "header": "tr|A0AAA9SG79-1|A0AAA9SG79_BOVIN Isoform 1 of G protein-coupled receptor 180 OS=Bos taurus OX=9913 GN=GPR180 PE=4 SV=1 CANONICAL=A0AAA9SG79-1" }, "locus": { "chromosome": "12", "start_pos": 69124605, "end_pos": 69099325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114227.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114227.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081488.1" } ] } }, { "isoform_ac": "F1N5D2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79/entry#F1N5D2-1", "sequence": { "sequence": "MRGLRLLAVALTCCWWPPGSQGKTLRGSFSSAAARDAQGQSIGHFEFHGDHALLCVRINNIAVAVGKEAKLYLFQAQEWLKLQEGGPEYSCSEKLSKAQLTMAVNQTEHNLTVSQIPYPQKWHVFYADKYTCREGGEESQMEDVPFEMMLLNPDAEGNPFDHFSAGESGLHEFFFLLVLVYFVIACIYAQSLWQAIKKGGPMHMVLKVLTTALLLQAGSAFANYIHFSSYSKDGIGVPFMGSLAEFFDIASQIQMLYLLLSLCMGWTIVRMKKSQSRPLQWDSTPASTGIAVFMVITQSILLLWEQFEETSSHSHHSHHSLAGILLIVLRICLALSLGCGLYQIITVERSTLKREFYITFAKFLLYRPIEINQDLLNRAASCGFCAIQVLRAFLSFLMTTKEIRSLQ", "length": 407, "header": "tr|F1N5D2-1|F1N5D2_BOVIN Computationally mapped isoform of G protein-coupled receptor 180 OS=Bos taurus OX=9913 GN=GPR180 PE=4 SV=3 CANONICAL=A0AAA9SG79-1" }, "locus": { "chromosome": "12", "start_pos": 69124605, "end_pos": 69099325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006985.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006985.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006985.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006985.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" } ], "pmid": "" }, { "name": "response to pheromone", "id": "GO:0019236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019236", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" }, { "id": "PF21870", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21870" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GPR180-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 134, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SG79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG79" }, { "id": "PF10192", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GPR180/TMEM145 transmembrane", "eco_id": "ECO_0000259", "start_pos": 177, "end_pos": 364, "start_aa": "Leu", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 110, "end_pos": 112 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG84-1", "uniprot_ac": "A0AAA9SG84", "uniprot_id": "A0AAA9SG84_BOVIN", "mass": { "chemical_mass": 85782.0, "monoisotopic_mass": 85782.0 }, "refseq": {}, "gene_names": [ { "name": "TBC1D23", "type": "recommended", "evidence": [ { "id": "A0AAA9SG84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 23", "type": "recommended", "evidence": [ { "id": "A0AAA9SG84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84", "locus": { "chromosome": "1", "start_pos": 44611551, "end_pos": 44549064, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015010", "url": "https://www.ensembl.org/id/ENSBTAG00000015010" } ] } } ], "crossref": [ { "id": "A0AAA9SG84", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG84", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015010", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015010", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20788", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20788", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518370", "url": "https://www.ncbi.nlm.nih.gov/gene/518370", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518370", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518370", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MU30", "url": "https://www.orthodb.org/?gene=F1MU30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13297", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13297", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13297:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13297:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19430", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19430", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU30", "url": "https://www.uniprot.org/uniprotkb/F1MU30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU30-1", "url": "https://www.uniprot.org/uniprotkb/F1MU30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKGHSSSPWKVSFGEHHRNPANSQHQLVRHKLGPRLPRTFYDVGYKSVSAPGPLFGKVTWTSTAMAEGEEVLPLPTSDDEGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIDHLSVPEEKAAQLLLDIESVITFYCKSRNIKYSSTLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFACYCSIEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILGQESDSKEEVIQFLENTPSSLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDDADLSQALCLAISVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSSVDGESSNGSNDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRMSFNLPWPDRTCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATKAIKQQIMKVLDALES", "length": 765, "header": "tr|A0AAA9SG84-1|A0AAA9SG84_BOVIN Isoform 1 of TBC1 domain family member 23 OS=Bos taurus OX=9913 GN=TBC1D23 PE=4 SV=1 CANONICAL=A0AAA9SG84-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84/entry#A0AAA9SG84-1", "sequence": { "sequence": "MLKGHSSSPWKVSFGEHHRNPANSQHQLVRHKLGPRLPRTFYDVGYKSVSAPGPLFGKVTWTSTAMAEGEEVLPLPTSDDEGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIDHLSVPEEKAAQLLLDIESVITFYCKSRNIKYSSTLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFACYCSIEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILGQESDSKEEVIQFLENTPSSLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDDADLSQALCLAISVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSSVDGESSNGSNDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRMSFNLPWPDRTCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATKAIKQQIMKVLDALES", "length": 765, "header": "tr|A0AAA9SG84-1|A0AAA9SG84_BOVIN Isoform 1 of TBC1 domain family member 23 OS=Bos taurus OX=9913 GN=TBC1D23 PE=4 SV=1 CANONICAL=A0AAA9SG84-1" }, "locus": { "chromosome": "1", "start_pos": 44610547, "end_pos": 44549079, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134465.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134465.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081493.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081493.1" } ] } }, { "isoform_ac": "A0AAA9T4H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84/entry#A0AAA9T4H4-1", "sequence": { "sequence": "MAEGEEVLPLPTSDDEGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIDHLSVPEEKAAQLLLDIESVITFYCKSRNIKYSSTLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFACYCSIEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILGQESDSKEEVIQFLENTPSSLNLEDIEDLFSLAQYYCSKTPASFRKEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSSVDGESSNGSNDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRMSFNLPWPDRTCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATKAIKQQIMKVLDALES", "length": 659, "header": "tr|A0AAA9T4H4-1|A0AAA9T4H4_BOVIN Computationally mapped isoform of TBC1 domain family member 23 OS=Bos taurus OX=9913 GN=TBC1D23 PE=4 SV=1 CANONICAL=A0AAA9SG84-1" }, "locus": { "chromosome": "1", "start_pos": 44610547, "end_pos": 44555416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109527.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109527.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091572.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091572.1" } ] } }, { "isoform_ac": "A0AAA9TL51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84/entry#A0AAA9TL51-1", "sequence": { "sequence": "MAEGEEVLPLPTSDDEGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIDHLSVPEEKAAQLLLDIESVITFYCKSRNIKYSSTLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFACYCSIEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILGQESDSKEEVIQFLENTPSSLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDDADLSQALCLAISVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSSVDGESSNGSNDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRMSFNLPWPDRTCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPRYLIPNAGDATKAIKQQIMKVLDALES", "length": 635, "header": "tr|A0AAA9TL51-1|A0AAA9TL51_BOVIN Computationally mapped isoform of TBC1 domain family member 23 OS=Bos taurus OX=9913 GN=TBC1D23 PE=4 SV=1 CANONICAL=A0AAA9SG84-1" }, "locus": { "chromosome": "1", "start_pos": 44610547, "end_pos": 44555416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107334.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107334.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097014.1" } ] } }, { "isoform_ac": "A0AAA9TRC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84/entry#A0AAA9TRC8-1", "sequence": { "sequence": "MGWYFRPARTEHYSQRLSGVHWDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFACYCSIEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILGQESDSKEEVIQFLENTPSSLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDDADLSQALCLAISVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSSVDGESSNGSNDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRMSFNLPWPDRTCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATKAIKQQIMKVLDALES", "length": 563, "header": "tr|A0AAA9TRC8-1|A0AAA9TRC8_BOVIN Computationally mapped isoform of TBC1 domain family member 23 OS=Bos taurus OX=9913 GN=TBC1D23 PE=4 SV=1 CANONICAL=A0AAA9SG84-1" }, "locus": { "chromosome": "1", "start_pos": 44610547, "end_pos": 44575497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135330.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135330.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101160.1" } ] } }, { "isoform_ac": "F1MU30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84/entry#F1MU30-1", "sequence": { "sequence": "MAEGEEVLPLPTSDDEGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIDHLSVPEEKAAQLLLDIESVITFYCKSRNIKYSSTLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFACYCSIEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILGQESDSKEEVIQFLENTPSSLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDDADLSQALCLAISVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSSVDGESSNGSNDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATKAIKQQIMKVLDALES", "length": 685, "header": "tr|F1MU30-1|F1MU30_BOVIN Computationally mapped isoform of TBC1 domain family member 23 OS=Bos taurus OX=9913 GN=TBC1D23 PE=4 SV=4 CANONICAL=A0AAA9SG84-1" }, "locus": { "chromosome": "1", "start_pos": 44610547, "end_pos": 44555416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032386.7", "url": "https://www.ensembl.org/id/ENSBTAT00000032386.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032319.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032319.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518370", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518370", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "WASH complex", "id": "GO:0071203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "vesicle tethering to Golgi", "id": "GO:0099041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" }, { "name": "embryonic brain development", "id": "GO:1990403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990403", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 533, "end_pos": 535, "annotation": "n_glycosylation_sequon" }, { "start_pos": 542, "end_pos": 544, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 726, "end_pos": 728, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 109, "end_pos": 290, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SG84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG84" }, { "id": "PS50206", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50206" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rhodanese", "eco_id": "ECO_0000259", "start_pos": 399, "end_pos": 511, "start_aa": "Glu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 533, "end_pos": 535 }, { "start_pos": 542, "end_pos": 544 }, { "start_pos": 577, "end_pos": 579 }, { "start_pos": 726, "end_pos": 728 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG90-1", "uniprot_ac": "A0AAA9SG90", "uniprot_id": "A0AAA9SG90_BOVIN", "mass": { "chemical_mass": 18546.0, "monoisotopic_mass": 18546.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG90/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG90", "locus": {} } ], "crossref": [ { "id": "A0AAA9SG90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG90", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SG90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCCGCSGGCGSSCGGCGSSCGGCGSCGGCGSSCCVPVCCCKPVCGCVPACSCSSCGKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSSCCVPVCCCVPACSCSSCGKAGCGSCGCSQSSCCKPCCSQSSCCVPVCCSQSSCCKPCCSQSSCCKPCCSQSSCCVPICCQCKI", "length": 207, "header": "tr|A0AAA9SG90-1|A0AAA9SG90_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SG90-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG90/entry#A0AAA9SG90-1", "sequence": { "sequence": "MGCCGCSGGCGSSCGGCGSSCGGCGSCGGCGSSCCVPVCCCKPVCGCVPACSCSSCGKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSSCCVPVCCCVPACSCSSCGKAGCGSCGCSQSSCCKPCCSQSSCCVPVCCSQSSCCKPCCSQSSCCKPCCSQSSCCVPICCQCKI", "length": 207, "header": "tr|A0AAA9SG90-1|A0AAA9SG90_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SG90-1" }, "locus": { "chromosome": "29", "start_pos": 49940748, "end_pos": 49940128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105738.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105738.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082889.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082889.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG97-1", "uniprot_ac": "A0AAA9SG97", "uniprot_id": "A0AAA9SG97_BOVIN", "mass": { "chemical_mass": 11957.0, "monoisotopic_mass": 11957.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Immunoglobulin V-set domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SG97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97", "locus": {} } ], "crossref": [ { "id": "A0AAA9SG97", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG97", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04983", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04983", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SG97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QQQVKQSPQSLTVQEGEISNLNCSYENSLFDYFPWYRQYPGKGPAFLIAIRSVVNEMEDGRLTVFLNKSAKQLSLHLTTSQPGDSATLLCTSGSFPMSQFFASGGKVL", "length": 108, "header": "tr|A0AAA9SG97-1|A0AAA9SG97_BOVIN Isoform 1 of Immunoglobulin V-set domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SG97-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97/entry#A0AAA9SG97-1", "sequence": { "sequence": "QQQVKQSPQSLTVQEGEISNLNCSYENSLFDYFPWYRQYPGKGPAFLIAIRSVVNEMEDGRLTVFLNKSAKQLSLHLTTSQPGDSATLLCTSGSFPMSQFFASGGKVL", "length": 108, "header": "tr|A0AAA9SG97-1|A0AAA9SG97_BOVIN Isoform 1 of Immunoglobulin V-set domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SG97-1" }, "locus": { "chromosome": "10", "start_pos": 23149765, "end_pos": 23148334, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106508.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106508.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081508.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081508.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG97" }, { "id": "SM00406", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin V-set", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 92, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG98-1", "uniprot_ac": "A0AAA9SG98", "uniprot_id": "A0AAA9SG98_BOVIN", "mass": { "chemical_mass": 135349.0, "monoisotopic_mass": 135349.0 }, "refseq": { "ac": "XP_005207644", "name": "synaptopodin-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207644" }, "gene_names": [ { "name": "SYNPO2", "type": "recommended", "evidence": [ { "id": "A0AAA9SG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ] }, { "name": "SYNPO2", "type": "synonym", "evidence": [ { "id": "XP_005207644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207644" } ] } ], "protein_names": [ { "name": "Synaptopodin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98/entry#names_and_taxonomy" } ] }, { "name": "Myopodin", "type": "synonym", "evidence": [ { "id": "A0AAA9SG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98/entry#names_and_taxonomy" } ] }, { "name": "synaptopodin-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005207644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207644" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNPO2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98", "locus": { "chromosome": "6", "start_pos": 6232763, "end_pos": 6434637, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006434", "url": "https://www.ensembl.org/id/ENSBTAG00000006434" } ] } } ], "crossref": [ { "id": "A0AAA9SG98", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG98", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10820", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10820", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540340", "url": "https://www.ncbi.nlm.nih.gov/gene/540340", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24217:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24217:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005207644", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207644", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RN75", "url": "https://www.uniprot.org/uniprotkb/F6RN75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RN75-1", "url": "https://www.uniprot.org/uniprotkb/F6RN75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTGDFICISMTGGAPWGFRLQGGKEQQQPLQVAKIRSQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLVKRPSSGISETSISETENKNQENVTHEGYVESTTLQIRPATKSQYREFYIVPIKSGAPLAEEQASGAGFSGSIKEETGLAPHTSDSESGRLPEEIILSEKAEAGRPGTVVELQLSLSQERHRGKSAAVVTLLGAEKSMSPDPEPNLLHDGIVHINSAPTSEKEDPPLRSSKTIQISSGQELRVIQGNEAADTGLPRVEVIFDCSDRQKTEGCRLQAAKGCVDSPVEGGQSEAPPSLVSFAVSSEGAEQGEDPRSERDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREAEEEEEEGDKEDPCEVAFLGASESEVDEELLSDTEDNTQVANFDWDSGLVDIEKKLSRGDKMEMLPDTTGKGALMFAKRRERMDQITAQKEEERAVGVPSREPDAAQTDGLRTVTSYQRKEEESVRVQSSVSKSYTEVSHGLGHVPQQNGFTGVSETAEAQRMIPVNRTAKPFPGSGNQPATPFSPSRNVTSPIADFPAPPPYSAVTPPPETFSRAVSSPTAGPAPPPPWPQPAPWSQPAFYDSSERIASRDERIAVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKKGPGAGADSGPEEDYLSLGAEACNFMQGSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPLWSPGVAPAQPPAFPTSNPSHGTVVSSIKIAQPSYAPARPASALNLAGPFKGPQAAVASRNYTPKPAAPTPTVNTAHAGAVGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHAARAHSPTPSLPAGWKYSSNVRAPPPVAYNPIHSPSYPPAAVKSQPSGLQASKTGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPAKPSVKASSVPAAKQALPPRPVNAGSPTNVQASSVYSVPAYTSPPSFFAEVTSPVSASPVPVAIPTSPKQESASTSYFVAPRPKFSAKKSGVTVQQTGRSLSLPGRPVPPAISATSPWLYQPAYSYTSKPTDGLEEAKKRLTPWEAAAKSPLGLVDEAFRPRNIQESIVANVVSAARRKVLPGQSEEWNARLSYVPQTQKTSVGSFAKQEYNVASLPNYSMPNSQYGSQAPHAYYRQPSRNDSEIMSMETRSDYCLSITNCNYNPHPRGWRRQT", "length": 1260, "header": "tr|A0AAA9SG98-1|A0AAA9SG98_BOVIN Isoform 1 of Synaptopodin-2 OS=Bos taurus OX=9913 GN=SYNPO2 PE=1 SV=1 CANONICAL=A0AAA9SG98-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98/entry#A0AAA9SG98-1", "sequence": { "sequence": "MGTGDFICISMTGGAPWGFRLQGGKEQQQPLQVAKIRSQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLVKRPSSGISETSISETENKNQENVTHEGYVESTTLQIRPATKSQYREFYIVPIKSGAPLAEEQASGAGFSGSIKEETGLAPHTSDSESGRLPEEIILSEKAEAGRPGTVVELQLSLSQERHRGKSAAVVTLLGAEKSMSPDPEPNLLHDGIVHINSAPTSEKEDPPLRSSKTIQISSGQELRVIQGNEAADTGLPRVEVIFDCSDRQKTEGCRLQAAKGCVDSPVEGGQSEAPPSLVSFAVSSEGAEQGEDPRSERDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREAEEEEEEGDKEDPCEVAFLGASESEVDEELLSDTEDNTQVANFDWDSGLVDIEKKLSRGDKMEMLPDTTGKGALMFAKRRERMDQITAQKEEERAVGVPSREPDAAQTDGLRTVTSYQRKEEESVRVQSSVSKSYTEVSHGLGHVPQQNGFTGVSETAEAQRMIPVNRTAKPFPGSGNQPATPFSPSRNVTSPIADFPAPPPYSAVTPPPETFSRAVSSPTAGPAPPPPWPQPAPWSQPAFYDSSERIASRDERIAVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKKGPGAGADSGPEEDYLSLGAEACNFMQGSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPLWSPGVAPAQPPAFPTSNPSHGTVVSSIKIAQPSYAPARPASALNLAGPFKGPQAAVASRNYTPKPAAPTPTVNTAHAGAVGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHAARAHSPTPSLPAGWKYSSNVRAPPPVAYNPIHSPSYPPAAVKSQPSGLQASKTGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPAKPSVKASSVPAAKQALPPRPVNAGSPTNVQASSVYSVPAYTSPPSFFAEVTSPVSASPVPVAIPTSPKQESASTSYFVAPRPKFSAKKSGVTVQQTGRSLSLPGRPVPPAISATSPWLYQPAYSYTSKPTDGLEEAKKRLTPWEAAAKSPLGLVDEAFRPRNIQESIVANVVSAARRKVLPGQSEEWNARLSYVPQTQKTSVGSFAKQEYNVASLPNYSMPNSQYGSQAPHAYYRQPSRNDSEIMSMETRSDYCLSITNCNYNPHPRGWRRQT", "length": 1260, "header": "tr|A0AAA9SG98-1|A0AAA9SG98_BOVIN Isoform 1 of Synaptopodin-2 OS=Bos taurus OX=9913 GN=SYNPO2 PE=1 SV=1 CANONICAL=A0AAA9SG98-1" }, "locus": { "chromosome": "6", "start_pos": 6434476, "end_pos": 6233767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102990.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102990.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084394.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084394.1" } ] } }, { "isoform_ac": "A0AAA9ST66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98/entry#A0AAA9ST66-1", "sequence": { "sequence": "MGTGDFICISMTGGAPWGFRLQGGKEQQQPLQVAKIRSQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLVKSRLDALFLFLEDQSHLPSLQHLLGYTSLLTATLASQRMGS", "length": 125, "header": "tr|A0AAA9ST66-1|A0AAA9ST66_BOVIN Computationally mapped isoform of Synaptopodin-2 OS=Bos taurus OX=9913 GN=SYNPO2 PE=3 SV=2 CANONICAL=A0AAA9SG98-1" }, "locus": { "chromosome": "6", "start_pos": 6434476, "end_pos": 6234186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132846.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132846.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088544.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088544.2" } ] } }, { "isoform_ac": "F6RN75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98/entry#F6RN75-1", "sequence": { "sequence": "MTWKQPRCPPADEWIRKLWYIYIMEYYSAIKKNTFESVLMRWMKLEPILQSEIRSQSKASGSGLCEGDEVVSINGNPCADLTYPEVIKLMESITDSLQMLVKRPSSGISETSISETENKNQENVTHEGYVESTTLQIRPATKSQYREFYIVPIKSGAPLAEEQASGAGFSGSIKEETGLAPHTSDSESGRLPEEIILSEKAEAGRPGTVVELQLSLSQERHRGKSAAVVTLLGAEKSMSPDPEPNLLHDGIVHINSAPTSEKEDPPLRSSKTIQISSGQELRVIQGNEAADTGLPRVEVIFDCSDRQKTEGCRLQAAKGCVDSPVEGGQSEAPPSLVSFAVSSEGAEQGEDPRSERDHSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREAEEEEEEGDKEDPCEVAFLGASESEVDEELLSDTEDNTQVANFDWDSGLVDIEKKLSRGDKMEMLPDTTGKGALMFAKRRERMDQITAQKEEERAVGVPSREPDAAQTDGLRTVTSYQRKEEESVRVQSSVSKSYTEVSHGLGHVPQQNGFTGVSETAEAQRMIPVNRTAKPFPGSGNQPATPFSPSRNVTSPIADFPAPPPYSAVTPPPETFSRAVSSPTAGPAPPPPWPQPAPWSQPAFYDSSERIASRDERIAVPAKRTGILQEAKRRSTTKPMFTFKEPKVSPNPELLSLLQNSEGKKGPGAGADSGPEEDYLSLGAEACNFMQGSSAKQKTPPPVAPKPAVKSSSSQPVTPVSPLWSPGVAPAQPPAFPTSNPSHGTVVSSIKIAQPSYAPARPASALNLAGPFKGPQAAVASRNYTPKPAAPTPTVNTAHAGAVGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHAARAHSPTPSLPAGWKYSSNVRAPPPVAYNPIHSPSYPPAAVKSQPSGLQASKTGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPAKPSVKASSVPAAKQALPPRPVNAGSPTNVQASSVYSVPAYTSPPSFFAEVTSPVSASPVPVAIPTSPKQESASTSYFVAPRPKFSAKKSGVTVQVWKPSVVEE", "length": 1107, "header": "tr|F6RN75-1|F6RN75_BOVIN Computationally mapped isoform of Synaptopodin 2 OS=Bos taurus OX=9913 GN=SYNPO2 PE=1 SV=2 CANONICAL=A0AAA9SG98-1" }, "locus": { "chromosome": "6", "start_pos": 6391469, "end_pos": 6264682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008434.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008434.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008434.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008434.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 623, "start_aa": "Thr", "end_pos": 623, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr623", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 771, "start_aa": "Thr", "end_pos": 771, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr771", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 845, "start_aa": "Thr", "end_pos": 845, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr845", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 901, "start_aa": "Thr", "end_pos": 901, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr901", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" }, { "name": "organelle", "id": "GO:0043226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "alpha-actinin binding", "id": "GO:0051393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" }, { "name": "filamin binding", "id": "GO:0031005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1204, "end_pos": 1206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1227, "end_pos": 1229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 605, "end_pos": 607, "annotation": "n_glycosylation_sequon" }, { "start_pos": 836, "end_pos": 838, "annotation": "n_glycosylation_sequon" }, { "start_pos": 970, "end_pos": 972, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG98" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 88, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 623, 771, 845, 901 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 1204, "end_pos": 1206 }, { "start_pos": 1227, "end_pos": 1229 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 605, "end_pos": 607 }, { "start_pos": 836, "end_pos": 838 }, { "start_pos": 970, "end_pos": 972 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGE0-1", "uniprot_ac": "A0AAA9SGE0", "uniprot_id": "A0AAA9SGE0_BOVIN", "mass": { "chemical_mass": 10756.0, "monoisotopic_mass": 10756.0 }, "refseq": {}, "gene_names": [ { "name": "S100A5", "type": "recommended", "evidence": [ { "id": "A0AAA9SGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ] } ], "protein_names": [ { "name": "Protein S100", "type": "recommended", "evidence": [ { "id": "A0AAA9SGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0", "locus": { "chromosome": "3", "start_pos": 16833547, "end_pos": 16828168, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000644", "url": "https://www.ensembl.org/id/ENSBTAG00000000644" } ] } } ], "crossref": [ { "id": "A0AAA9SGE0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKELCLGEMRESSIDDLMKSLDKNSDQEIDFKEYSVFLTTLCMAYNDFFLEENQ", "length": 92, "header": "tr|A0AAA9SGE0-1|A0AAA9SGE0_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100A5 PE=3 SV=1 CANONICAL=A0AAA9SGE0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0/entry#A0AAA9SGE0-1", "sequence": { "sequence": "METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKELCLGEMRESSIDDLMKSLDKNSDQEIDFKEYSVFLTTLCMAYNDFFLEENQ", "length": 92, "header": "tr|A0AAA9SGE0-1|A0AAA9SGE0_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=S100A5 PE=3 SV=1 CANONICAL=A0AAA9SGE0-1" }, "locus": { "chromosome": "3", "start_pos": 16832543, "end_pos": 16830569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112041.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112041.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081557.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081557.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "pmid": "" }, { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE0" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 82, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGF9-1", "uniprot_ac": "A0AAA9SGF9", "uniprot_id": "A0AAA9SGF9_BOVIN", "mass": { "chemical_mass": 23452.0, "monoisotopic_mass": 23452.0 }, "refseq": {}, "gene_names": [ { "name": "SPACDR", "type": "recommended", "evidence": [ { "id": "A0AAA9SGF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9" } ] } ], "protein_names": [ { "name": "Sperm acrosome developmental regulator", "type": "synonym", "evidence": [ { "id": "A0AAA9SGF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPACDR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9", "locus": { "chromosome": "25", "start_pos": 36091628, "end_pos": 36087967, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016765", "url": "https://www.ensembl.org/id/ENSBTAG00000016765" } ] } } ], "crossref": [ { "id": "A0AAA9SGF9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016765", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016765", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617958", "url": "https://www.ncbi.nlm.nih.gov/gene/617958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MRFFRWV", "url": "https://omabrowser.org/oma/group/MRFFRWV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR39221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39221:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39221:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPF5", "url": "https://www.uniprot.org/uniprotkb/F1MPF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPF5-1", "url": "https://www.uniprot.org/uniprotkb/F1MPF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVVIKFFRWIWQKISRWVFFWKHKAKSVIMDHTDSKKNELKAEKAFKVSETFKLVEPPKEAKVSKMDVSPKVVDPCLLAKTTMDGAAVEAGRRRRSLLKLPQAAVKSVSMLMASALQSGWQMCSWKSSVSSTSVASQMKTRSPLESREAAMLREVYLVLWAIRKQLRQLARRQERRRRHHLRAHMGPQPDPAQGLKQDARSPL", "length": 204, "header": "tr|A0AAA9SGF9-1|A0AAA9SGF9_BOVIN Isoform 1 of Sperm acrosome developmental regulator OS=Bos taurus OX=9913 GN=SPACDR PE=4 SV=1 CANONICAL=A0AAA9SGF9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9/entry#A0AAA9SGF9-1", "sequence": { "sequence": "MAVVIKFFRWIWQKISRWVFFWKHKAKSVIMDHTDSKKNELKAEKAFKVSETFKLVEPPKEAKVSKMDVSPKVVDPCLLAKTTMDGAAVEAGRRRRSLLKLPQAAVKSVSMLMASALQSGWQMCSWKSSVSSTSVASQMKTRSPLESREAAMLREVYLVLWAIRKQLRQLARRQERRRRHHLRAHMGPQPDPAQGLKQDARSPL", "length": 204, "header": "tr|A0AAA9SGF9-1|A0AAA9SGF9_BOVIN Isoform 1 of Sperm acrosome developmental regulator OS=Bos taurus OX=9913 GN=SPACDR PE=4 SV=1 CANONICAL=A0AAA9SGF9-1" }, "locus": { "chromosome": "25", "start_pos": 36091389, "end_pos": 36088665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092616.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092616.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082960.1" } ] } }, { "isoform_ac": "F1MPF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9/entry#F1MPF5-1", "sequence": { "sequence": "MGNALGAPGMCSLTVFFWKHKAKSVIMDHTDSKKNELKAEKAFKVSETFKLVEPPKEAKVSKMDVSPKVVDPCLLAKTTMDGAAVEAGRRRRSLLKLPQAAVKSVSMLMASALQSGWQMCSWKSSVSSTSVASQMKTRSPLESREAAMLREVYLVLWAIRKQLRQLARRQERRRRHHLRAHMGPQPDPAQGLKQDARSPL", "length": 200, "header": "tr|F1MPF5-1|A0AAA9SGF9_BOVIN Computationally mapped isoform of Sperm acrosome developmental regulator OS=Bos taurus OX=9913 GN=SPACDR PE=4 SV=2 CANONICAL=A0AAA9SGF9-1" }, "locus": { "chromosome": "25", "start_pos": 36091389, "end_pos": 36088248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022295.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022295.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022295.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022295.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8IZ16-1", "protein_name": "Sperm acrosome developmental regulator", "gene_name": "SPACDR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVVMKFFRWVRRAWQRIISWVFFWRQKIKPTISGHPDSKKHSLKKMEKTLQVVETLRLVELPKEAKPKLGESPELADPCVLAKTTEETEVELGQQGQSLLQLPRTAVKSVSTLMVSALQSGWQMCSWKSSVSSASVSSQVRTQSPLKTPEAELLWEVYLVLWAVRKHLRRLYRRQERHRRHHVRCHAAPRPNPAQSLKLDAQSPL", "length": 206 }, "evidence": [ { "id": "A0AAA9SGF9", "url": "https://omabrowser.org/oma/group/A0AAA9SGF9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGI8-1", "uniprot_ac": "A0AAA9SGI8", "uniprot_id": "A0AAA9SGI8_BOVIN", "mass": { "chemical_mass": 44378.0, "monoisotopic_mass": 44378.0 }, "refseq": {}, "gene_names": [ { "name": "COPS7A", "type": "recommended", "evidence": [ { "id": "A0AAA9SGI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ] } ], "protein_names": [ { "name": "COP9 signalosome subunit 7A", "type": "synonym", "evidence": [ { "id": "A0AAA9SGI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8#function" }, { "database": "UniProtKB", "id": "ARBA00025037", "url": "https://www.uniprot.org/uniprotkb/ARBA00025037#function" }, { "database": "UniProtKB", "id": "F6QE33", "url": "https://www.uniprot.org/uniprotkb/F6QE33#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COPS7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8", "locus": { "chromosome": "5", "start_pos": 103712243, "end_pos": 103719964, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011111", "url": "https://www.ensembl.org/id/ENSBTAG00000011111" } ] } } ], "crossref": [ { "id": "A0AAA9SGI8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011111", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6QE33", "url": "https://www.orthodb.org/?gene=F6QE33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15350", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15350", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15350:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15350:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6781823", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QE33", "url": "https://www.uniprot.org/uniprotkb/F6QE33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QE33-1", "url": "https://www.uniprot.org/uniprotkb/F6QE33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRHQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGPAGGVFCLGICGRTEGSFPAHSKAKCQKNRRTKYYAEAHWVPGDLDPRPLNFEQIAQYVGIHSGAEGACWAPACAQLEMQNGGHCPCSRGTLSSACLPPPHRIVGEELIVNFNFCIKTTGGLPWWLSGREPACQCGRHRFSP", "length": 405, "header": "tr|A0AAA9SGI8-1|A0AAA9SGI8_BOVIN Isoform 1 of COP9 signalosome subunit 7A OS=Bos taurus OX=9913 GN=COPS7A PE=3 SV=1 CANONICAL=A0AAA9SGI8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8/entry#A0AAA9SGI8-1", "sequence": { "sequence": "MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRHQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGPAGGVFCLGICGRTEGSFPAHSKAKCQKNRRTKYYAEAHWVPGDLDPRPLNFEQIAQYVGIHSGAEGACWAPACAQLEMQNGGHCPCSRGTLSSACLPPPHRIVGEELIVNFNFCIKTTGGLPWWLSGREPACQCGRHRFSP", "length": 405, "header": "tr|A0AAA9SGI8-1|A0AAA9SGI8_BOVIN Isoform 1 of COP9 signalosome subunit 7A OS=Bos taurus OX=9913 GN=COPS7A PE=3 SV=1 CANONICAL=A0AAA9SGI8-1" }, "locus": { "chromosome": "5", "start_pos": 103719313, "end_pos": 103713247, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090334.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090334.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082987.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082987.1" } ] } }, { "isoform_ac": "F6QE33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8/entry#F6QE33-1", "sequence": { "sequence": "MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVREKTGRLLSLLSSAVESENRGEGRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRHQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN", "length": 298, "header": "tr|F6QE33-1|F6QE33_BOVIN Computationally mapped isoform of COP9 signalosome subunit 7A OS=Bos taurus OX=9913 GN=COPS7A PE=3 SV=2 CANONICAL=A0AAA9SGI8-1" }, "locus": { "chromosome": "5", "start_pos": 103719313, "end_pos": 103714497, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014754.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014754.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014754.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014754.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5696394", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" }, { "id": "R-BTA-6781823", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "resource": "Reactome", "description": "Formation of TC-NER Pre-Incision Complex" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ], "pmid": "" }, { "name": "COP9 signalosome", "id": "GO:0008180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008180", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "COP9 signalosome assembly", "id": "GO:0010387", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010387", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ], "pmid": "" }, { "name": "protein deneddylation", "id": "GO:0000338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI8" }, { "id": "PS50250", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50250" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 159, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGJ8-1", "uniprot_ac": "A0AAA9SGJ8", "uniprot_id": "A0AAA9SGJ8_BOVIN", "mass": { "chemical_mass": 11362.0, "monoisotopic_mass": 11362.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SGJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGJ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SYELTQPTSVSVALGQTAKITCSGDLLDEQYTQWYQQKPGQGPVRVIYKDSERPSGISDRFSGSSSGKTATLTISGAQTEDEADYYCQSADSKNRSYSKHEMY", "length": 103, "header": "tr|A0AAA9SGJ8-1|A0AAA9SGJ8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SGJ8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8/entry#A0AAA9SGJ8-1", "sequence": { "sequence": "SYELTQPTSVSVALGQTAKITCSGDLLDEQYTQWYQQKPGQGPVRVIYKDSERPSGISDRFSGSSSGKTATLTISGAQTEDEADYYCQSADSKNRSYSKHEMY", "length": 103, "header": "tr|A0AAA9SGJ8-1|A0AAA9SGJ8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SGJ8-1" }, "locus": { "chromosome": "17", "start_pos": 71077486, "end_pos": 71075965, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090630.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090630.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085304.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085304.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGJ8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 98, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGK5-1", "uniprot_ac": "A0AAA9SGK5", "uniprot_id": "A0AAA9SGK5_BOVIN", "mass": { "chemical_mass": 9178.0, "monoisotopic_mass": 9178.0 }, "refseq": {}, "gene_names": [ { "name": "C20H5orf58", "type": "recommended", "evidence": [ { "id": "A0AAA9SGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5" } ] } ], "protein_names": [ { "name": "Chromosome 5 open reading frame 58", "type": "synonym", "evidence": [ { "id": "A0AAA9SGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C20H5orf58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SGK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKNNVTDHKLNVEAIIKNINTISLELKKMNELSQLLLCDLTLHFSHPVKTDDLKETERNSPHFEESKMPDLSLASDSFI", "length": 80, "header": "tr|A0AAA9SGK5-1|A0AAA9SGK5_BOVIN Isoform 1 of Chromosome 5 open reading frame 58 OS=Bos taurus OX=9913 GN=C20H5orf58 PE=4 SV=1 CANONICAL=A0AAA9SGK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGK5/entry#A0AAA9SGK5-1", "sequence": { "sequence": "MIKNNVTDHKLNVEAIIKNINTISLELKKMNELSQLLLCDLTLHFSHPVKTDDLKETERNSPHFEESKMPDLSLASDSFI", "length": 80, "header": "tr|A0AAA9SGK5-1|A0AAA9SGK5_BOVIN Isoform 1 of Chromosome 5 open reading frame 58 OS=Bos taurus OX=9913 GN=C20H5orf58 PE=4 SV=1 CANONICAL=A0AAA9SGK5-1" }, "locus": { "chromosome": "20", "start_pos": 2129924, "end_pos": 2123169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107137.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107137.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081628.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGL1-1", "uniprot_ac": "A0AAA9SGL1", "uniprot_id": "A0AAA9SGL1_BOVIN", "mass": { "chemical_mass": 31275.0, "monoisotopic_mass": 31275.0 }, "refseq": { "ac": "XP_005227708", "name": "protein sprouty homolog 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227708" }, "gene_names": [ { "name": "SPRY3", "type": "recommended", "evidence": [ { "id": "A0AAA9SGL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1" } ] }, { "name": "SPRY3", "type": "synonym", "evidence": [ { "id": "XP_005227708", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227708" } ] } ], "protein_names": [ { "name": "Sprouty RTK signaling antagonist 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SGL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1/entry#names_and_taxonomy" } ] }, { "name": "protein sprouty homolog 3", "type": "synonym", "evidence": [ { "id": "XP_005227708", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227708" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPRY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1", "locus": { "chromosome": "X", "start_pos": 35441214, "end_pos": 35453000, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000067551", "url": "https://www.ensembl.org/id/ENSBTAG00000067551" } ] } } ], "crossref": [ { "id": "A0AAA9SGL1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "539402", "url": "https://www.ncbi.nlm.nih.gov/gene/539402", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539402", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539402", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQNHTNT", "url": "https://omabrowser.org/oma/group/CQNHTNT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12365", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12365", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12365:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12365:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227708", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227708", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAAVTDDFQQILPIEQLRSTHASNDYVDRPPVPCKQALSSPSLIVQTHKSDWSLATMPTALPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGTGAHPKADGALKGEAEHSAMHPSEHLFICEECGRCKCVLCTAARPLPACWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPGSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV", "length": 288, "header": "tr|A0AAA9SGL1-1|A0AAA9SGL1_BOVIN Isoform 1 of Sprouty RTK signaling antagonist 3 OS=Bos taurus OX=9913 GN=SPRY3 PE=3 SV=1 CANONICAL=A0AAA9SGL1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1/entry#A0AAA9SGL1-1", "sequence": { "sequence": "MDAAVTDDFQQILPIEQLRSTHASNDYVDRPPVPCKQALSSPSLIVQTHKSDWSLATMPTALPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGTGAHPKADGALKGEAEHSAMHPSEHLFICEECGRCKCVLCTAARPLPACWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPGSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV", "length": 288, "header": "tr|A0AAA9SGL1-1|A0AAA9SGL1_BOVIN Isoform 1 of Sprouty RTK signaling antagonist 3 OS=Bos taurus OX=9913 GN=SPRY3 PE=3 SV=1 CANONICAL=A0AAA9SGL1-1" }, "locus": { "chromosome": "X", "start_pos": 35447264, "end_pos": 35446401, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113890.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113890.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082833.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082833.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539402", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539402", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A5X6-1", "protein_name": "Sprouty RTK signaling antagonist 3", "gene_name": "SPRY3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDAAVADDCQQILPIEQLRSTHASNDYVDRPPVPCKQALSSPSLIVHTHKSDWSLATMPTALPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGTGAHPKADGALKGEAEPSAEHPSEHLFICEECGRCKCVLCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPGSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV", "length": 288 }, "evidence": [ { "id": "A0AAA9SGL1", "url": "https://omabrowser.org/oma/group/A0AAA9SGL1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YEH5-1", "protein_name": "Sprouty RTK signaling antagonist 3", "gene_name": "SPRY3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQLSSSVAELSCDETMDPPAEDFQQVLSIDQIRSIRASNNYVERPATCFQQARSNPSLSQPPHKQEWTQDRLASSTLQDLHRSHSQQPHMPPLQQAMSHSSTASSVSQSTTASEQRLLSALTPSHSGHSLIRTQPRAGELKAEESPLKGAVEKGSLHGGHLFVCEECGRCKCARCTAARGLPSCWLCNQRCLCSPESLLDYGTCLCCVKGLFYHCSSDDEDTCADDPCSCGPGSCCARWAAMSFLSLLMPCLCCYFPTLGCLKLCQRGYDGLKRPGCRCQTHTNTVCRKISSSSGTPFPKALDKPV", "length": 306 }, "evidence": [ { "id": "A0AAA9SGL1", "url": "https://omabrowser.org/oma/group/A0AAA9SGL1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B5DF90-1", "protein_name": "Sprouty RTK signaling antagonist 3", "gene_name": "Spry3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATDDPQPILPIAQLRSVHASNDYVDRPPAPRKPTLSSPSLTLQTHKSDWSLATTPTALPRSVSQCHQLQPLPQHLSQSSIASSVSQTTTASDQRLLATMTPSPSGPSSILRTHPKVDGALKGGAEQSAGQSSDHRLFICEECGRCKCVPCTAVRPLPSCWVCNQRCLCSAESLLDYGTCLCCVQGVFYHCSTDDEDNCADEPCSCGPGSRFLRWAAMGVISVFLPCLCCYLPTRGCLRLCQRGYDSLRRPGCRCKMHTNTVCRKMSSGGSPCPKAQEKSV", "length": 281 }, "evidence": [ { "id": "A0AAA9SGL1", "url": "https://omabrowser.org/oma/group/A0AAA9SGL1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43610-1", "protein_name": "Protein sprouty homolog 3", "gene_name": "SPRY3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSSPSLIVQTHKSDWSLATMPTSLPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCKCVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV", "length": 288 }, "evidence": [ { "id": "A0AAA9SGL1", "url": "https://omabrowser.org/oma/group/A0AAA9SGL1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGM4-1", "uniprot_ac": "A0AAA9SGM4", "uniprot_id": "A0AAA9SGM4_BOVIN", "mass": { "chemical_mass": 56198.0, "monoisotopic_mass": 56198.0 }, "refseq": {}, "gene_names": [ { "name": "LOC104968500", "type": "recommended", "evidence": [ { "id": "A0AAA9SGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain containing 5B", "type": "recommended", "evidence": [ { "id": "A0AAA9SGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC104968500", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGM4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "104968500", "url": "https://www.ncbi.nlm.nih.gov/gene/104968500", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968500", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968500", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEDQTFFQGCENITDSLGAESLASVPPQDTLMENSECDQENWHVRFRTFSSSEESDPVKDLKRLRELCHLWLRPDLHTKEQMMDRLVLEQFMICMPLECQVLLKESGVQSCKDLEDVLRNKQKHKTWVSRTLMMGVGQGDTCKVQGSQDRTCGFGSVSVVPKQTIVCIQGQKYLVRDPNIEMVEAKAGHMDDERHLCGGPQPSSRVIPPEDGQEGSQELQNLPGATNLSREQDERALPPETVPETGELEGLTPRENLEKDLLEDRGETKTLQSEAPQLLKGPEADVSTTGGSRRGPLKNRRHMKRKRDSSPTCQDVCQEAATCLDQGEFSGQLGSHSIDVSGTVGPTSLPEGAETPGRAPSECRMCKKSFPYQSQLILHQRTHTGERPFQCDICAKGFIQPSDLRVHERIHTGEKPYSCDLCLKKFTHDSTLRAHKRTHTQEKPFRCEHCDRAFSHRGNLNVHRRIHSGLKPYVCPECHSAFRQLGTFKRHQKIHSR", "length": 498, "header": "tr|A0AAA9SGM4-1|A0AAA9SGM4_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC104968500 PE=3 SV=1 CANONICAL=A0AAA9SGM4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4/entry#A0AAA9SGM4-1", "sequence": { "sequence": "MAEDQTFFQGCENITDSLGAESLASVPPQDTLMENSECDQENWHVRFRTFSSSEESDPVKDLKRLRELCHLWLRPDLHTKEQMMDRLVLEQFMICMPLECQVLLKESGVQSCKDLEDVLRNKQKHKTWVSRTLMMGVGQGDTCKVQGSQDRTCGFGSVSVVPKQTIVCIQGQKYLVRDPNIEMVEAKAGHMDDERHLCGGPQPSSRVIPPEDGQEGSQELQNLPGATNLSREQDERALPPETVPETGELEGLTPRENLEKDLLEDRGETKTLQSEAPQLLKGPEADVSTTGGSRRGPLKNRRHMKRKRDSSPTCQDVCQEAATCLDQGEFSGQLGSHSIDVSGTVGPTSLPEGAETPGRAPSECRMCKKSFPYQSQLILHQRTHTGERPFQCDICAKGFIQPSDLRVHERIHTGEKPYSCDLCLKKFTHDSTLRAHKRTHTQEKPFRCEHCDRAFSHRGNLNVHRRIHSGLKPYVCPECHSAFRQLGTFKRHQKIHSR", "length": 498, "header": "tr|A0AAA9SGM4-1|A0AAA9SGM4_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC104968500 PE=3 SV=1 CANONICAL=A0AAA9SGM4-1" }, "locus": { "chromosome": "18", "start_pos": 63671383, "end_pos": 63668228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124366.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124366.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081648.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081648.1" } ] } }, { "isoform_ac": "A0AAA9TY10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4/entry#A0AAA9TY10-1", "sequence": { "sequence": "MAEDQTFFQGCENITDSLGAESLASVPPQDTLMENSECDQENWHVRFRTFSSSEESDPVKDLKRLRELCHLWLRPDLHTKEQMMDRLVLEQFMICMPLECQVLLKESGVQSCKDLEDVLRNKQKHKTWTIVCIQGQKYLVRDPNIEMVEAKAGHMDDERHLCGGPQPSSRVIPPEDGQEGSQELQNLPGATNLSREQDERALPPETVPETGELEGLTPRENLEKDLLEDRGETKTLQSEAPQLLKGPEADVSTTGGSRRGPLKNRRHMKRKRDSSPTCQDVCQEAATCLDQGEFSGQLGSHSIDVSGTVGPTSLPEGAETPGRAPSECRMCKKSFPYQSQLILHQRTHTGERPFQCDICAKGFIQPSDLRVHERIHTGEKPYSCDLCLKKFTHDSTLRAHKRTHTQEKPFRCEHCDRAFSHRGNLNVHRRIHSGLKPYVCPECHSAFRQLGTFKRHQKIHSR", "length": 462, "header": "tr|A0AAA9TY10-1|A0AAA9TY10_BOVIN Computationally mapped isoform of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC104968500 PE=4 SV=1 CANONICAL=A0AAA9SGM4-1" }, "locus": { "chromosome": "18", "start_pos": 63671383, "end_pos": 63668228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103240.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 348, "start_aa": "Thr", "end_pos": 348, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr348", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:104968500", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968500", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 362, "end_pos": 389, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM4" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 124, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 348 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 }, { "start_pos": 228, "end_pos": 230 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGM6-1", "uniprot_ac": "A0AAA9SGM6", "uniprot_id": "A0AAA9SGM6_BOVIN", "mass": { "chemical_mass": 31101.0, "monoisotopic_mass": 31101.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "small monomeric GTPase", "type": "recommended", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGM6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47980", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47980", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAGDPPTGQRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWVGQDTAGQERYRTITTAYYRGAMGFLLMYDVANQESFAAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPTEEGRRLADDLGQCPTWATGPGPPRTKPPSLCLSPRSNQSPILCPLKICPEKYLHVYHLLHLIPEDLPTDNLYCPTALGTQTQQNHFWEFILQTTPVWAVTGVSNYSTVIRRESLAASQVSHSGGSSYT", "length": 278, "header": "tr|A0AAA9SGM6-1|A0AAA9SGM6_BOVIN Isoform 1 of small monomeric GTPase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SGM6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6/entry#A0AAA9SGM6-1", "sequence": { "sequence": "MASAGDPPTGQRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWVGQDTAGQERYRTITTAYYRGAMGFLLMYDVANQESFAAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPTEEGRRLADDLGQCPTWATGPGPPRTKPPSLCLSPRSNQSPILCPLKICPEKYLHVYHLLHLIPEDLPTDNLYCPTALGTQTQQNHFWEFILQTTPVWAVTGVSNYSTVIRRESLAASQVSHSGGSSYT", "length": 278, "header": "tr|A0AAA9SGM6-1|A0AAA9SGM6_BOVIN Isoform 1 of small monomeric GTPase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SGM6-1" }, "locus": { "chromosome": "7", "start_pos": 15745629, "end_pos": 15743994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106265.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106265.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085335.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGN5-1", "uniprot_ac": "A0AAA9SGN5", "uniprot_id": "A0AAA9SGN5_BOVIN", "mass": { "chemical_mass": 23049.0, "monoisotopic_mass": 23049.0 }, "refseq": { "ac": "XP_002691673", "name": "peptidyl-tRNA hydrolase isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691673" }, "gene_names": [ { "name": "PTRH1", "type": "recommended", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] }, { "name": "PTRH1", "type": "synonym", "evidence": [ { "id": "XP_002691673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691673" } ] } ], "protein_names": [ { "name": "peptidyl-tRNA hydrolase", "type": "recommended", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.29", "type": "synonym", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5/entry#names_and_taxonomy" } ] }, { "name": "peptidyl-tRNA hydrolase isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002691673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691673" } ] } ], "function": [ { "annotation": "Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes. Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes. Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5#function" }, { "database": "UniProtKB", "id": "ARBA00053438", "url": "https://www.uniprot.org/uniprotkb/ARBA00053438#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTRH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5", "locus": { "chromosome": "11", "start_pos": 98393074, "end_pos": 98395617, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012736", "url": "https://www.ensembl.org/id/ENSBTAG00000012736" } ] } } ], "crossref": [ { "id": "A0AAA9SGN5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012736", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012736", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00462", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00462", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505680", "url": "https://www.ncbi.nlm.nih.gov/gene/505680", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036416", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036416", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505680", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505680", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BK88", "url": "https://www.orthodb.org/?gene=E1BK88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17224:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17224:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01195", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01195", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691673", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "54448", "url": "https://www.rhea-db.org/rhea/54448", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK88", "url": "https://www.uniprot.org/uniprotkb/E1BK88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK88-1", "url": "https://www.uniprot.org/uniprotkb/E1BK88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPGLSRAGLWLSRAMSRCVLEPRPAGKRWLVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWERDRRCAADLAQASLGDAQLVLLRPRRLMNLNGHSVAQAVELFGLTAEEVYLVHDELDKPLGKVALKLGGSARGHNGVRSCMSCLNSNAMPRLQVGIGRPTHRDAVQAYVLGRFSPAEQELLPPVLERAVDLLLGHIHQRSRESSSGP", "length": 214, "header": "tr|A0AAA9SGN5-1|A0AAA9SGN5_BOVIN Isoform 1 of peptidyl-tRNA hydrolase OS=Bos taurus OX=9913 GN=PTRH1 PE=3 SV=1 CANONICAL=A0AAA9SGN5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5/entry#A0AAA9SGN5-1", "sequence": { "sequence": "MGLPGLSRAGLWLSRAMSRCVLEPRPAGKRWLVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWERDRRCAADLAQASLGDAQLVLLRPRRLMNLNGHSVAQAVELFGLTAEEVYLVHDELDKPLGKVALKLGGSARGHNGVRSCMSCLNSNAMPRLQVGIGRPTHRDAVQAYVLGRFSPAEQELLPPVLERAVDLLLGHIHQRSRESSSGP", "length": 214, "header": "tr|A0AAA9SGN5-1|A0AAA9SGN5_BOVIN Isoform 1 of peptidyl-tRNA hydrolase OS=Bos taurus OX=9913 GN=PTRH1 PE=3 SV=1 CANONICAL=A0AAA9SGN5-1" }, "locus": { "chromosome": "11", "start_pos": 98395418, "end_pos": 98393687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096467.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096467.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084513.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084513.1" } ] } }, { "isoform_ac": "E1BK88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5/entry#E1BK88-1", "sequence": { "sequence": "MGLPGLSRAGLWLSRAMSRCVLEPRPAGKRWLVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWERDRRCAADLAQASLGDAQLVLLRPRRLMNLNGHSVAQAVELFGLTAEEVYLVHDELDKPLGKVALKLGGSARQCHGCRWASGGRPTGTQCRPMCWAASPLLSRSCCLQCWSVLWTC", "length": 183, "header": "tr|E1BK88-1|A0AAA9SGN5_BOVIN Computationally mapped isoform of peptidyl-tRNA hydrolase OS=Bos taurus OX=9913 GN=PTRH1 PE=3 SV=3 CANONICAL=A0AAA9SGN5-1" }, "locus": { "chromosome": "11", "start_pos": 98395418, "end_pos": 98393734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016930.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016930.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016930.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016930.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:505680", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505680", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peptidyl-tRNA hydrolase activity", "id": "GO:0004045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54448", "name": "", "equation": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZ85-1", "Q3ZBL5-1", "Q3T116-1", "A0AAA9SGN5-1" ], "evidence": [ { "id": "54448", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54448" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SGN5", "gene_name": "PTRH1", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] } ] }, { "uniprot_ac": "Q3SZ85", "gene_name": "PTRHD1", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] } ] }, { "uniprot_ac": "Q3T116", "gene_name": "MRPL58", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] } ] }, { "uniprot_ac": "Q3ZBL5", "gene_name": "PTRH2", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.29", "ec_name": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "3.1.1.29", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29" }, { "id": "3.1.1.29", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.29" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGS7-1", "uniprot_ac": "A0AAA9SGS7", "uniprot_id": "A0AAA9SGS7_BOVIN", "mass": { "chemical_mass": 51390.0, "monoisotopic_mass": 51390.0 }, "refseq": {}, "gene_names": [ { "name": "SLC46A2", "type": "recommended", "evidence": [ { "id": "A0AAA9SGS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ] } ], "protein_names": [ { "name": "Solute carrier family 46 member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SGS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC46A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7", "locus": { "chromosome": "8", "start_pos": 102117910, "end_pos": 102129395, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013670", "url": "https://www.ensembl.org/id/ENSBTAG00000013670" } ] } } ], "crossref": [ { "id": "A0AAA9SGS7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGS7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23507", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23507", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23507:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23507:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCQGSICPWRDPLPRLQVWTWIEPVVASTQVATSLYDAGLLLVVKASFGVGTSSNHSSSPSPRGALEDEQQRAISNFYIVYHLVMGLTPLLSAYGLGWLSDRYHRKVSICVPLLGFLLSRLVLLLKVLLDWPVEMLYAGAALTGLCGGFSAFWSGVMALGSLSSSEGRRSLRLIVIDLILGLAGFCGSMVSGHLFKQMVGHSKQGLVLTACSVSCATCALLYSLFVLKVPESKAKPRKAVDIVPGTVGRYDTLDPDQTDKQSVVRPPPPPATAKPKQIIIGLLFVGAIIYDLAVVGTVDVMPLFVLREPLSWNQVQVGYGMASGYTIFITSFLGVLVFSRYLQDTTMIMIGMVSFASGALLLAFVKETYMFYIARAIMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLTLTGVVTSTLYNKIYQLTMEKFIGTCFALSSFLSFLAILPIGDLLGSTLEPSISLTVVLQAAE", "length": 475, "header": "tr|A0AAA9SGS7-1|A0AAA9SGS7_BOVIN Isoform 1 of Solute carrier family 46 member 2 OS=Bos taurus OX=9913 GN=SLC46A2 PE=3 SV=1 CANONICAL=A0AAA9SGS7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7/entry#A0AAA9SGS7-1", "sequence": { "sequence": "MCQGSICPWRDPLPRLQVWTWIEPVVASTQVATSLYDAGLLLVVKASFGVGTSSNHSSSPSPRGALEDEQQRAISNFYIVYHLVMGLTPLLSAYGLGWLSDRYHRKVSICVPLLGFLLSRLVLLLKVLLDWPVEMLYAGAALTGLCGGFSAFWSGVMALGSLSSSEGRRSLRLIVIDLILGLAGFCGSMVSGHLFKQMVGHSKQGLVLTACSVSCATCALLYSLFVLKVPESKAKPRKAVDIVPGTVGRYDTLDPDQTDKQSVVRPPPPPATAKPKQIIIGLLFVGAIIYDLAVVGTVDVMPLFVLREPLSWNQVQVGYGMASGYTIFITSFLGVLVFSRYLQDTTMIMIGMVSFASGALLLAFVKETYMFYIARAIMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLTLTGVVTSTLYNKIYQLTMEKFIGTCFALSSFLSFLAILPIGDLLGSTLEPSISLTVVLQAAE", "length": 475, "header": "tr|A0AAA9SGS7-1|A0AAA9SGS7_BOVIN Isoform 1 of Solute carrier family 46 member 2 OS=Bos taurus OX=9913 GN=SLC46A2 PE=3 SV=1 CANONICAL=A0AAA9SGS7-1" }, "locus": { "chromosome": "8", "start_pos": 102129284, "end_pos": 102125101, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110647.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110647.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082900.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082900.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway", "id": "GO:0070430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070430", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ], "pmid": "" }, { "name": "cyclic-GMP-AMP transmembrane import across plasma membrane", "id": "GO:0140361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140361", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cyclic-GMP-AMP transmembrane transporter activity", "id": "GO:0140360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGT7-1", "uniprot_ac": "A0AAA9SGT7", "uniprot_id": "A0AAA9SGT7_BOVIN", "mass": { "chemical_mass": 24872.0, "monoisotopic_mass": 24872.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "palmitoyl-protein hydrolase", "type": "recommended", "evidence": [ { "id": "A0AAA9SGT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7/entry#names_and_taxonomy" } ] }, { "name": "3.1.2.22", "type": "synonym", "evidence": [ { "id": "A0AAA9SGT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGT7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGT7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10655", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10655", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10655:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10655:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTSARLAFPPDSEAGRIQAILQMRSWELQANNIQAYLGENVGTVPEPAIKHGTAGLTPSPPSGSLTSSTSALMHSWFGLMGLNLDAPEDEAGIKKATENIKALIEHEMKNGIPANRIVLGRFSQGGALSLYTALTCSHPLAGTVALSCWLPLHRASPQAANGSAKDLTILQCRGELDPMVPVRFGALTAEKLWSIVTPARVQFKKYPGVTHSPCPQEMAAVKKFLEKLLPPV", "length": 233, "header": "tr|A0AAA9SGT7-1|A0AAA9SGT7_BOVIN Isoform 1 of palmitoyl-protein hydrolase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SGT7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7/entry#A0AAA9SGT7-1", "sequence": { "sequence": "MGTSARLAFPPDSEAGRIQAILQMRSWELQANNIQAYLGENVGTVPEPAIKHGTAGLTPSPPSGSLTSSTSALMHSWFGLMGLNLDAPEDEAGIKKATENIKALIEHEMKNGIPANRIVLGRFSQGGALSLYTALTCSHPLAGTVALSCWLPLHRASPQAANGSAKDLTILQCRGELDPMVPVRFGALTAEKLWSIVTPARVQFKKYPGVTHSPCPQEMAAVKKFLEKLLPPV", "length": 233, "header": "tr|A0AAA9SGT7-1|A0AAA9SGT7_BOVIN Isoform 1 of palmitoyl-protein hydrolase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SGT7-1" }, "locus": { "chromosome": "8", "start_pos": 38152854, "end_pos": 38143882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007837.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007837.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084555.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084555.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT7" }, { "id": "PF02230", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02230" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phospholipase/carboxylesterase/thioesterase", "eco_id": "ECO_0000259", "start_pos": 62, "end_pos": 229, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.22", "ec_name": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "3.1.2.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22" }, { "id": "3.1.2.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.22" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGT8-1", "uniprot_ac": "A0AAA9SGT8", "uniprot_id": "A0AAA9SGT8_BOVIN", "mass": { "chemical_mass": 51598.0, "monoisotopic_mass": 51598.0 }, "refseq": {}, "gene_names": [ { "name": "DIPK1A", "type": "recommended", "evidence": [ { "id": "A0AAA9SGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8" } ] } ], "protein_names": [ { "name": "Divergent protein kinase domain 1A", "type": "synonym", "evidence": [ { "id": "A0AAA9SGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIPK1A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8", "locus": { "chromosome": "3", "start_pos": 50629761, "end_pos": 50499751, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002028", "url": "https://www.ensembl.org/id/ENSBTAG00000002028" } ] } } ], "crossref": [ { "id": "A0AAA9SGT8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR022049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21093", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21093", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21093:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21093:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12260", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12260", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14875", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14875", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QG02", "url": "https://www.uniprot.org/uniprotkb/F6QG02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QG02-1", "url": "https://www.uniprot.org/uniprotkb/F6QG02-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRAPKYDLFSQRDVKFQELIKTKYNVSHLMNELELGGVQARFSYVRMKYLFFSWLAVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS", "length": 450, "header": "tr|A0AAA9SGT8-1|A0AAA9SGT8_BOVIN Isoform 1 of Divergent protein kinase domain 1A OS=Bos taurus OX=9913 GN=DIPK1A PE=3 SV=1 CANONICAL=A0AAA9SGT8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8/entry#A0AAA9SGT8-1", "sequence": { "sequence": "MQRAPKYDLFSQRDVKFQELIKTKYNVSHLMNELELGGVQARFSYVRMKYLFFSWLAVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS", "length": 450, "header": "tr|A0AAA9SGT8-1|A0AAA9SGT8_BOVIN Isoform 1 of Divergent protein kinase domain 1A OS=Bos taurus OX=9913 GN=DIPK1A PE=3 SV=1 CANONICAL=A0AAA9SGT8-1" }, "locus": { "chromosome": "3", "start_pos": 50628554, "end_pos": 50532212, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122721.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122721.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082910.1" } ] } }, { "isoform_ac": "A0AAA9SH33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8/entry#A0AAA9SH33-1", "sequence": { "sequence": "MARSLCPGAWLRKPCYLQARFSYVRMKYLFFSWLAVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS", "length": 369, "header": "tr|A0AAA9SH33-1|A0AAA9SH33_BOVIN Computationally mapped isoform of Divergent protein kinase domain 1A OS=Bos taurus OX=9913 GN=DIPK1A PE=3 SV=1 CANONICAL=A0AAA9SGT8-1" }, "locus": { "chromosome": "3", "start_pos": 50628554, "end_pos": 50499812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130420.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130420.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085519.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085519.1" } ] } }, { "isoform_ac": "A0AAA9TK45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8/entry#A0AAA9TK45-1", "sequence": { "sequence": "MGLHVIAFVSQKLFTLENAYPPSPTIRDVGGLVSKSCPNLMAPWTVAHQAPLSMGLSWQEYWSGLHFFLQGTFLSQGSNLCLLHGRQSPALQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS", "length": 421, "header": "tr|A0AAA9TK45-1|A0AAA9TK45_BOVIN Computationally mapped isoform of Divergent protein kinase domain 1A OS=Bos taurus OX=9913 GN=DIPK1A PE=3 SV=1 CANONICAL=A0AAA9SGT8-1" }, "locus": { "chromosome": "3", "start_pos": 50628554, "end_pos": 50620903, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131921.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131921.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097293.1" } ] } }, { "isoform_ac": "A0AAA9TQW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8/entry#A0AAA9TQW3-1", "sequence": { "sequence": "MARSLCPGAWLRKPCYLQCDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS", "length": 383, "header": "tr|A0AAA9TQW3-1|A0AAA9TQW3_BOVIN Computationally mapped isoform of Divergent protein kinase domain 1A OS=Bos taurus OX=9913 GN=DIPK1A PE=3 SV=1 CANONICAL=A0AAA9SGT8-1" }, "locus": { "chromosome": "3", "start_pos": 50628554, "end_pos": 50499812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110846.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110846.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100975.1" } ] } }, { "isoform_ac": "F6QG02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8/entry#F6QG02-1", "sequence": { "sequence": "MARSLCPGAWLRKPCYLQARFSYVRMKYLFFSWLAVFVGSWIIYVQYSTYTELCRGKDCKKIIMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS", "length": 392, "header": "tr|F6QG02-1|F6QG02_BOVIN Computationally mapped isoform of Divergent protein kinase domain 1A OS=Bos taurus OX=9913 GN=DIPK1A PE=3 SV=1 CANONICAL=A0AAA9SGT8-1" }, "locus": { "chromosome": "3", "start_pos": 50628554, "end_pos": 50499812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002628.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002628.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002628.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002628.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT8" }, { "id": "SM01299", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01299" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM69 N-terminal", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 199, "start_aa": "Ala", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 448, "end_pos": 450 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGU9-1", "uniprot_ac": "A0AAA9SGU9", "uniprot_id": "A0AAA9SGU9_BOVIN", "mass": { "chemical_mass": 33927.0, "monoisotopic_mass": 33927.0 }, "refseq": { "ac": "XP_002695235", "name": "sulfotransferase 2A1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695235" }, "gene_names": [ { "name": "LOC514658", "type": "recommended", "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ] }, { "name": "LOC514658", "type": "synonym", "evidence": [ { "id": "XP_002695235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695235" } ] } ], "protein_names": [ { "name": "Sulfotransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9/entry#names_and_taxonomy" } ] }, { "name": "sulfotransferase 2A1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002695235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695235" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC514658", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGU9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "514658", "url": "https://www.ncbi.nlm.nih.gov/gene/514658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514658", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514658", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQGLSAY", "url": "https://omabrowser.org/oma/group/CQGLSAY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11783", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11783", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695235", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695235", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "70607", "url": "https://www.rhea-db.org/rhea/70607", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGKCVWFEGIPFPSLDYSPELLREVQESFLVKDKDVLLLTFPKSGTNWLIETVCLIYSKGDPKWVQSEPIWDRSPWVETKHGYELLKEKEGPRLISSHLPIQLFPKSFFKSKAKMIYLIRNPRDVLVSGYFFWRSAKFVKRPQSLEQYFEWFVEGNVVFGSWFDHARGWMSMRDKENFLILSYEEMKWDMRSTVEKICQFLGKKLEPEELNSVLKNSSFQAMKENSMSNYSLLKGQYFEENGQLLRKGVTGDWRNYFTVAQAETFDKLFQEKMADLPQDLFLWKQ", "length": 286, "header": "tr|A0AAA9SGU9-1|A0AAA9SGU9_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=LOC514658 PE=3 SV=1 CANONICAL=A0AAA9SGU9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9/entry#A0AAA9SGU9-1", "sequence": { "sequence": "MTGKCVWFEGIPFPSLDYSPELLREVQESFLVKDKDVLLLTFPKSGTNWLIETVCLIYSKGDPKWVQSEPIWDRSPWVETKHGYELLKEKEGPRLISSHLPIQLFPKSFFKSKAKMIYLIRNPRDVLVSGYFFWRSAKFVKRPQSLEQYFEWFVEGNVVFGSWFDHARGWMSMRDKENFLILSYEEMKWDMRSTVEKICQFLGKKLEPEELNSVLKNSSFQAMKENSMSNYSLLKGQYFEENGQLLRKGVTGDWRNYFTVAQAETFDKLFQEKMADLPQDLFLWKQ", "length": 286, "header": "tr|A0AAA9SGU9-1|A0AAA9SGU9_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=LOC514658 PE=3 SV=1 CANONICAL=A0AAA9SGU9-1" }, "locus": { "chromosome": "18", "start_pos": 54771042, "end_pos": 54753788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119001.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119001.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085416.1" } ] } }, { "isoform_ac": "A0AAA9TPQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9/entry#A0AAA9TPQ9-1", "sequence": { "sequence": "MEFPSEHLREVQEDFIIKDEDVLLLTYPQSGTNWLIETVCLIYSKGDPKWVQSEPIWDRSPWVETKHGYELLKEKEGPRLISSHLPIQLFPKSFFKSKAKMIYLIRNPRDVLVSGYFFWRSAKFVKRPQSLEQYFEWFVEGNVVFGSWFDHARGWMSMRDKENFLILSYEEMKWDMRSTVEKICQFLGKKLEPEELNSVLKNSSFQAMKENSMSNYSLLKGQYFEENGQLLRKGVTGDWRNYFTVAQAETFDKLFQEKMADLPQDLFLWKQ", "length": 271, "header": "tr|A0AAA9TPQ9-1|A0AAA9TPQ9_BOVIN Computationally mapped isoform of Sulfotransferase OS=Bos taurus OX=9913 GN=LOC514658 PE=3 SV=1 CANONICAL=A0AAA9SGU9-1" }, "locus": { "chromosome": "18", "start_pos": 54781930, "end_pos": 54753788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121245.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121245.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098360.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514658", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514658", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P15709-1", "protein_name": "Sulfotransferase 2A1", "gene_name": "Sult2a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPDYTWFEGIPFHAFGISKETLQNVCNKFVVKDEDLILLAYPKSGTNWLIEIVCLIQTKGDPKWIQSVTIWDRSPWIETDLGYDMLIKKKGPRLITSHLPMHLFSKSLFSSKAKVIYLVRNPRDVLVSGYYFWGNSTLAKKPDSLGTYVEWFLKGNVLYGSWFEHIRAWLSMREWDNFLLLYYEDMKKDTMGTIKKICDFLGKKLEPDELDLVLKYSSFQVMKENDMSNYSLLMKKSIFTGIGLMRKGTVGDWKNHFTVSQAEAFDKVFQEKMAGFPPGMFPWE", "length": 284 }, "evidence": [ { "id": "A0AAA9SGU9", "url": "https://omabrowser.org/oma/group/A0AAA9SGU9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P52843-1", "protein_name": "Sulfotransferase 2A1", "gene_name": "Sult2a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPKSGTNWLIEIVCLIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLITSHLPIHLFSKSFFSSKAKAIYLVRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLKGNVLFGSWFEHVRGWLSMREWDNFLVLYYEDIKKDTKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNFSLIKEDQVTNGLKLMRKGTIGDWKNHFTVAQAEAFDKVFQEKMAGFPPGIFPWE", "length": 285 }, "evidence": [ { "id": "A0AAA9SGU9", "url": "https://omabrowser.org/oma/group/A0AAA9SGU9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q06520-1", "protein_name": "Sulfotransferase 2A1", "gene_name": "SULT2A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE", "length": 285 }, "evidence": [ { "id": "A0AAA9SGU9", "url": "https://omabrowser.org/oma/group/A0AAA9SGU9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FZ80-1", "protein_name": "Cytosolic sulfotransferase 17", "gene_name": "SOT17", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MESKTINDVVVSESNHELASSSPSEFEKNQKHYQEIIATLPHKDGWRPKDPFVEYGGHWWLQPLLEGLLHAQKFFKARPNDFFVCSYPKTGTTWLKALTFAIANRSKFDVSTNPLLKRNPHEFVPYIEIDFPFFPSVDVLKDEGNTLFSTHIPYDLLPESVVKSGCKIVYIWRDPKDTFVSMWTFAHKERSQQGPVVSIEEAFDKYCQGLSAYGPYLDHVLGYWKAYQANPDQILFLKYETMRADPLPYVKRLAEFMGYGFTKEEEEGNVVEKVVKLCSFETLKNLEANKGEKDREDRPAVYANSAYFRKGKVGDWQNYLTPEMVARIDGLMEEKFKGTGFLSSKS", "length": 346 }, "evidence": [ { "id": "A0AAA9SGU9", "url": "https://omabrowser.org/oma/group/A0AAA9SGU9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sulfation", "id": "GO:0051923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aryl sulfotransferase activity", "id": "GO:0004062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004062", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "70607", "name": "", "equation": "4-ethylphenol + 3'-phosphoadenylyl sulfate = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T0Y3-1", "P50227-1", "P19217-1", "A0AAA9RW31-1", "A0A3Q1N4J6-1", "F1MZX9-1", "E1BG19-1", "E1BAC7-1", "E1BIS9-1", "A0ABI0NTS0-1", "A0AAA9SGU9-1", "A0ABI0P531-1", "E1BJ78-1" ], "evidence": [ { "id": "70607", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70607" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1N4J6", "gene_name": "", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1N4J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4J6" } ] } ] }, { "uniprot_ac": "A0AAA9RW31", "gene_name": "LOC100300896", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0AAA9RW31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW31" } ] } ] }, { "uniprot_ac": "A0AAA9SGU9", "gene_name": "LOC514658", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" } ] } ] }, { "uniprot_ac": "A0ABI0NTS0", "gene_name": "SULT1C2", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0ABI0NTS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTS0" } ] } ] }, { "uniprot_ac": "A0ABI0P531", "gene_name": "LOC112446736", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0ABI0P531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P531" } ] } ] }, { "uniprot_ac": "E1BAC7", "gene_name": "SULT1D1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BAC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAC7" } ] } ] }, { "uniprot_ac": "E1BG19", "gene_name": "SULT2A1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BG19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG19" } ] } ] }, { "uniprot_ac": "E1BIS9", "gene_name": "SULT1C3", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIS9" } ] } ] }, { "uniprot_ac": "E1BJ78", "gene_name": "LOC783020", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "E1BJ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ78" } ] } ] }, { "uniprot_ac": "F1MZX9", "gene_name": "SULT6B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "F1MZX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZX9" } ] } ] }, { "uniprot_ac": "P19217", "gene_name": "SULT1E1", "activity": [ { "ec_number": "2.8.2.4", "activity": "estrone + 3'-phosphoadenylyl sulfate = estrone 3-sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "P19217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19217" } ] }, { "ec_number": "2.8.2.4", "activity": "", "evidence": [ { "id": "P19217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19217" } ] } ] }, { "uniprot_ac": "P50227", "gene_name": "SULT1A1", "activity": [ { "ec_number": "2.8.2.1", "activity": "a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "P50227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P50227" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P50227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P50227" } ] } ] }, { "uniprot_ac": "Q3T0Y3", "gene_name": "SULT1B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] }, { "ec_number": "2.8.2.1", "activity": "a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+).", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q3T0Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y3" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU9" }, { "id": "PF00685", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfotransferase", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 277, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 230, "end_pos": 232 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGY4-1", "uniprot_ac": "A0AAA9SGY4", "uniprot_id": "A0AAA9SGY4_BOVIN", "mass": { "chemical_mass": 129393.0, "monoisotopic_mass": 129393.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Myosin XVA", "type": "recommended", "evidence": [ { "id": "A0AAA9SGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SGY4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22692", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22692", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22692:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22692:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00784", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00784", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26570", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26570", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW37-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVVADSDGYCSHNENDLDSLGEPAVPHKGLDCYLDSLFDPVLSCGDADLEKPTAIAYRMKGGGQPGGDGSSSTEGPPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQAMALQQQPLSPTPRPFPPEKPLASEARPKFVGTGLPAKPVLLQAAPKPAAPAPLAKAPRTPTKPVAAPILPQGWASPESTSPCLELVRSSTLNSEHFPQPTQQIKDIVRQHQQLPRGGRPEALRKDGGRVFVKRPDPHEEALTILRGQMSPPVAAPGTQVPREAVALVKPVTSTQRPSVGPAPALPSRSLEPPEDPVQTRLHRLPNPNFYGYRDTPWQIFLRKEVFYPKDDHSHPVQLDLLFRQVLHDTLSEACLRISAEERLQMKALFAQNQLDTQRPLVTESVKRAVVSTARDSWEVYFSRLFPATGSVGTGVQMLAVSHTGIKLLRVVKGSHEASGQLRVLRTYSFADILFVTIPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRLGYSAGCVVGKKVVYLEELRCRGPDFGWRFGTIHGRVGRFPSDLVQPAAAPDFLQLPAEPGRGRAAAVAAAVASTAAAQEVGRRREGPPLRAGSMDRGEDSLALPPYTMLEFAQKYFRDPQRRPQDGPRLKSKEGRESRTLEDMLCFTKTPLQDSLIEFSDSSLNKMATDMFLAVMRFMGDAPLKGQSELDVLCTLLKLCRDHEVMRDECYCQVVKQITDNTSTKQDSCQRGWRLLYIVAAYHSCSEVLQPHLTHFLQDVSRTPGLPFQGIAKACEQNLKKTLRFGGRLELPGSMELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEELCAEMALTRPEAFDEYVIFVVTNRGQHVCPLSRRTYILDVASEMAQVDGGYALWFRRVLWDQPLKFDNELYVTMHYNQVLPDYLKGLFSSMPAGRPSEQQLQQVSKLAALQHRAKDHFYLPSAREAQGYIPAQLYRTEASSTWLRLLGQHRQQMQALSPHQARAQFLGLLSALPMFGSSFFLVQSCSTTAVPAPCILAVNQNGLNFLSTETHELMVKFPLKEIQSTRTQRPTADSSCPYVEVALGDVTAQHTVQLQLEQRAGQCRLMSPAGPGAVSGGGCACGEPAQCPR", "length": 1172, "header": "tr|A0AAA9SGY4-1|A0AAA9SGY4_BOVIN Isoform 1 of Myosin XVA OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SGY4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4/entry#A0AAA9SGY4-1", "sequence": { "sequence": "MPVVADSDGYCSHNENDLDSLGEPAVPHKGLDCYLDSLFDPVLSCGDADLEKPTAIAYRMKGGGQPGGDGSSSTEGPPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQAMALQQQPLSPTPRPFPPEKPLASEARPKFVGTGLPAKPVLLQAAPKPAAPAPLAKAPRTPTKPVAAPILPQGWASPESTSPCLELVRSSTLNSEHFPQPTQQIKDIVRQHQQLPRGGRPEALRKDGGRVFVKRPDPHEEALTILRGQMSPPVAAPGTQVPREAVALVKPVTSTQRPSVGPAPALPSRSLEPPEDPVQTRLHRLPNPNFYGYRDTPWQIFLRKEVFYPKDDHSHPVQLDLLFRQVLHDTLSEACLRISAEERLQMKALFAQNQLDTQRPLVTESVKRAVVSTARDSWEVYFSRLFPATGSVGTGVQMLAVSHTGIKLLRVVKGSHEASGQLRVLRTYSFADILFVTIPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRLGYSAGCVVGKKVVYLEELRCRGPDFGWRFGTIHGRVGRFPSDLVQPAAAPDFLQLPAEPGRGRAAAVAAAVASTAAAQEVGRRREGPPLRAGSMDRGEDSLALPPYTMLEFAQKYFRDPQRRPQDGPRLKSKEGRESRTLEDMLCFTKTPLQDSLIEFSDSSLNKMATDMFLAVMRFMGDAPLKGQSELDVLCTLLKLCRDHEVMRDECYCQVVKQITDNTSTKQDSCQRGWRLLYIVAAYHSCSEVLQPHLTHFLQDVSRTPGLPFQGIAKACEQNLKKTLRFGGRLELPGSMELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEELCAEMALTRPEAFDEYVIFVVTNRGQHVCPLSRRTYILDVASEMAQVDGGYALWFRRVLWDQPLKFDNELYVTMHYNQVLPDYLKGLFSSMPAGRPSEQQLQQVSKLAALQHRAKDHFYLPSAREAQGYIPAQLYRTEASSTWLRLLGQHRQQMQALSPHQARAQFLGLLSALPMFGSSFFLVQSCSTTAVPAPCILAVNQNGLNFLSTETHELMVKFPLKEIQSTRTQRPTADSSCPYVEVALGDVTAQHTVQLQLEQRAGQCRLMSPAGPGAVSGGGCACGEPAQCPR", "length": 1172, "header": "tr|A0AAA9SGY4-1|A0AAA9SGY4_BOVIN Isoform 1 of Myosin XVA OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SGY4-1" }, "locus": { "chromosome": "19", "start_pos": 34467088, "end_pos": 34445635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092282.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092282.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083161.1" } ] } }, { "isoform_ac": "A0AAA9SW37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4/entry#A0AAA9SW37-1", "sequence": { "sequence": "MPVVADSDGYCSHNENDLDSLGEPAVPHKGLDCYLDSLFDPVLSCGDADLEKPTAIAYRMKGGGQPGGDGSSSTEGPPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQAMALQQQPLSPTPRPFPPEKPLASEARPKFVGTGLPAKPVLLQAAPKPAAPAPLAKAPRTPTKPVAAPILPQGWASPESTSPCLELVRSSTLNSEHFPQPTQQIKDIVRQHQQLPRGGRPEALRKDGGRVFVKRPDPHEEALTILRGQMSPPVAAPGTQVPREAVALVKPVTSTQRPSVGPAPALPSRSLEPPEDPVQTRLHRLPNPNFYGYRDTPWQIFLRKEVFYPKDDHSHPVQLDLLFRQVLHDTLSEACLRISAEERLQMKALFAQNQLDTQRPLVTESVKRAVVSTARDSWEVYFSRLFPATGSVGTGVQMLAVSHTGIKLLRVVKGSHEASGQLRVLRTYSFADILFVTIPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRLGYSAGCVVGKKVVYLEELRCRGPDFGWRFGTIHGRVGRFPSDLVQPAAAPDFLQLPAEPGRGRAAAVAAAVASTAAAQEVGRRREGPPLRAGSMDRGEDSLALPPYTMLEFAQKYFRDPQRRPQDGPRLKSKEGRESRTLEDMLCFTKTPLQDSLIEFSDSSLNKMATDMFLAVMRFMGDAPLKGQSELDVLCTLLKLCRDHEVMRDECYCQVVKQITDNTSTKQDSCQRGWRLLYIVAAYHSCSEVLQPHLTHFLQDVSRTPGLPFQGIAKACEQNLKKTLRFGGRLELPGSMELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEELCAEMALTRPEAFDEYVIFVVTNRGQHVCPLSRRTYILDVASEMAQVDGGYALWFRRVLWDQPLKFDNELYVTMHYNQVLPDYLKGLFSSMPAGRPSEQQLQQVSKLAALQHRAKDHFYLPSAREAQGYIPAQLYRTEASSTWLRLLGQHRQQMQALSPHQARAQFLELQHHGCASPLHPRCQPERPQLPQHDPRPGAVSGGGCACGEPAQCPR", "length": 1096, "header": "tr|A0AAA9SW37-1|A0AAA9SW37_BOVIN Computationally mapped isoform of Myosin XVA OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SGY4-1" }, "locus": { "chromosome": "19", "start_pos": 34467088, "end_pos": 34445635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108047.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108047.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090695.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" }, { "id": "PS50057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FERM", "eco_id": "ECO_0000259", "start_pos": 853, "end_pos": 1172, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" }, { "id": "PS51016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MyTH4", "eco_id": "ECO_0000259", "start_pos": 694, "end_pos": 848, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY4" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 511, "end_pos": 597, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 768, "end_pos": 770 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGY6-1", "uniprot_ac": "A0AAA9SGY6", "uniprot_id": "A0AAA9SGY6_BOVIN", "mass": { "chemical_mass": 318988.0, "monoisotopic_mass": 318988.0 }, "refseq": {}, "gene_names": [ { "name": "FCGBP", "type": "recommended", "evidence": [ { "id": "A0AAA9SGY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6" } ] } ], "protein_names": [ { "name": "Fc gamma binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SGY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FCGBP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6", "locus": { "chromosome": "18", "start_pos": 49408001, "end_pos": 49467025, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005261", "url": "https://www.ensembl.org/id/ENSBTAG00000005261" } ] } } ], "crossref": [ { "id": "cd19941", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19941", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ACHESLD", "url": "https://omabrowser.org/oma/group/ACHESLD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11339:SF244", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11339:SF244", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSLRSWWMLWAGATLLWGLTQEASVDPQSSGGEEFLTAFLQNYNPGYSKAYLCLLLSSLSDSLTSVSILSRADGTTQKVTVRPGQSVLVNISAKAEMVGSKTFQHAVVVRADRAISVQAVNAKPSTADVTLLRPVRALGTEYFVLTPSSPSSRNLQEFAVVAGAAGASVSIRLKGSVTFKGKSYAAGRVLNVTLDPYQVAQIQSTSNLSGSKVTASSPVAVLSGHSCAQRNSNCNHVVEQLLPTSAWGTRYVVPPLSFHSQHDVIYVMASQATRLTYHLGGTTGSRGLQAGNVAEFEIQQSRPLYLSADLGIQVLMFGAGTTKDGETYDPHLVLIPDVAAYCPAYVVRSVPGSKGVALVVTPTKAAGELTMDGQRLGAKLSWAAVPGSEFSYAELDFGTTDSVHVAEAATSFGLLTFGLYQDVSFGTAAACGRTQRSLEKTPCEGKQCAARQVCKVVNGQARCVAPVATCRAQGDPHYTTFDGRYYDMMGTCLYSLAELQSNDDSLPAFSVDAKNEHRGSRRVSYVGLVTVRAYNHAVSLARGEVGFARIDNQRSRLPASLSGGRLRVYQSGTRAVVELDFGLVVSYDWDAQLALSLPVRFQGQVRGLCGNYNGDPTDDFLTPDSEQAPDAVEFASSWKLDDGDYLCEDGCQENCPACTPEQAQLYEDSRFCGMLTQLNGPFAACHEALDPQPFLKECVYDLCVVNGDRASLCRGLSAYTQACLELGISVGNWRSSANCPLSCPANSRYELCAPACQASCNPDAAPSNCSARQCVEGCVCLEGFVESGGACVAASSCGCIYEGRPLAPGQEVWADTTCQRRCTCDAATGQVRCSDTQGCPKGERCLVQNGLRGCYPDRFGTCKGSGDPHYVSFDGRRFDFMGTCTYLLAGSCGQASGLQTFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGRVLVDDILQYLPFQAADGQVQVFRQGQNAVIRTDFGLTVTYNWDAHVTVKVPTSYAGALCGLCGNFNEDPADDFALKSGGQAANALAFGNSWQEETRPGCGAAQPGDCPKLDSLVAEQLQSKKECGILADPSGPFRECHRTLDPQGAVRDCVYDRCLLPGQSGPLCDALAAYADACQAAGLTVHPWRSEELCPLSCPSHSHYEECSYGCPLSCGDLPVSGGCGFECKEGCVCDEGFVLNGESCVPLASCGCVYQGSYYPPEQTFYPGPECDSLCYCEEGGLVSCVPSSCGPHEACQPSNGVLGCVAVGSTTCQASGDPHYTTFDGQRFDFMGTCVYVLAQTCGTRPGLPQFAVLQENVAWGNGKVSVTKAITVQVANFTLRLEQNQWKVTVNGVDRRLPVLLDEGRIHVFQHGSDVVIETDFGLRVAYDLVYNVRVTVPGNYYQQLCGLCGNYNGNPKDDFQKPDGSQAGSANEFGNSWEEAVPDSPCLPPPTCQPGDKDCDTELECKPELQNKYEQQEFCGLLTSPTGPLAACHKLLDPQGPLQDCVFDLCVGGGNESILCSNIHAYVSACQAAGGHVEPWRTESFCPMQCPPNSHYEVCADTCSLGCSALSAPPQCPERCAEGCQCDSGFLSDGQGCVPIQECGCYHNGIYYEPEKVVLTDNCQQQCVCQPGKGLVCQNHSCSDGQVCQPSGGVLSCVTKDPCHSVTCRPQETCQNKNGQGVCVPNYQATCWLWGDPHYHSFDGWNFDFQGTCNYVLASTDCPGSNAQGLTPFTVTTKNENRGNPSVSYVRLVTVTTLNTNISIHKGEIGKVRVNGVLRALPVSVADGRLLVTHGASKAVLATDFGLQVTYDWDWRVEVTLPSSYHSAICGLCGNMDRNPSNDQAFPNGTLAPSIPIWGGSWRVPGWDPLCWDECQGSCPTCAEDRLEEYGGPGFCGPLAPGSGGPFAACHDHVAPDSFFKGCVLDVCLGGGAKDILCQALAAYAAACQAAGIVIKDWRTEAGCELPCPENSHYELCGPPCPASCPSPTPPTSPAVCEGPCVEGCQCNSGFVLSADRCVPLEGGCGCWANGIYHEAGSEFWADATCSQRCQCGPRGGSLVCKPASCRLGEECALLPSGQHGCQPVSTAECQAWGDPHYITLDGHRFDFQGACEYLLSAPCHDLPEGALNFTVTVANEHRGSQAVSYTRTVTLHIYGHSFTLSAGWPRQLQVDGKLVALPFQLDSRVHAYLSGADVVVTTASGISLAFDGNSNVRLRVPAAYAGALCGLCGNYNKNPNDDLNAVEGNPDRWQVGGAAGCGECVPGPCPKPCTPEQQEPFGGPDACGVISSLEGPLAPCHSLIPPEQYFQACLLDACQAQGHPGGLCPAVAAYVAACQAAGAQLGEWRRPDFCPFQCPAHSHYQLCGDSCPVSCPSLSAPEGCESTCREGCVCDAGFVLSGDTCVPVGQCGCLHEGRYYPLGETFYPGPECGRHCQCGPGGQVSCQEGETCRPYEECRVQDGVQACRPTGCGRCLANGGVHYITLDGRVYDLHGSCSYILAQVCHPQPGDEDFTIVLEKNAAGDPQRVVVTVAGQVVTLARGPQVTVDGEAVALPVAVGHVRVTAEGRNIVLQTTKDLRLLFDGDAHILISIPSPFRNRLCGLCGNFNGNWNDDLDLPSGTTAPSVDAFGAAWRAPGSSQGCSEGCGPQGCPVCSAEQTAPYESLEACGQLRDANGPFSACHAALSPSEYFRQCVYDLCAQKGNVTYLCRSLAAYTAACQAAGMAVKPWRTDSFCPLQCPTNSHYSVCTRSCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHDGRYLPVNSSLLTSDCSQRCSCSSSTGLTCQAASCPLGRVCEVQAGTRDCWVPHGLCSLSVGANLTTFDGAHSAVSSPGVYEISFRCPGSQETVPWYRVVADVQPCKGKVEAVARVHIFFQDGLVTVTQNKGVWVNGLQVDLPAEVLTSVSVSQNPDGSVLVQQKEGVQVKLGADGQLAVVVSDDHAGKLCGACGNFDADWSNDWPNSQETTLENWKAQDFSPCQD", "length": 3001, "header": "tr|A0AAA9SGY6-1|A0AAA9SGY6_BOVIN Isoform 1 of Fc gamma binding protein OS=Bos taurus OX=9913 GN=FCGBP PE=1 SV=1 CANONICAL=A0AAA9SGY6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6/entry#A0AAA9SGY6-1", "sequence": { "sequence": "MGSLRSWWMLWAGATLLWGLTQEASVDPQSSGGEEFLTAFLQNYNPGYSKAYLCLLLSSLSDSLTSVSILSRADGTTQKVTVRPGQSVLVNISAKAEMVGSKTFQHAVVVRADRAISVQAVNAKPSTADVTLLRPVRALGTEYFVLTPSSPSSRNLQEFAVVAGAAGASVSIRLKGSVTFKGKSYAAGRVLNVTLDPYQVAQIQSTSNLSGSKVTASSPVAVLSGHSCAQRNSNCNHVVEQLLPTSAWGTRYVVPPLSFHSQHDVIYVMASQATRLTYHLGGTTGSRGLQAGNVAEFEIQQSRPLYLSADLGIQVLMFGAGTTKDGETYDPHLVLIPDVAAYCPAYVVRSVPGSKGVALVVTPTKAAGELTMDGQRLGAKLSWAAVPGSEFSYAELDFGTTDSVHVAEAATSFGLLTFGLYQDVSFGTAAACGRTQRSLEKTPCEGKQCAARQVCKVVNGQARCVAPVATCRAQGDPHYTTFDGRYYDMMGTCLYSLAELQSNDDSLPAFSVDAKNEHRGSRRVSYVGLVTVRAYNHAVSLARGEVGFARIDNQRSRLPASLSGGRLRVYQSGTRAVVELDFGLVVSYDWDAQLALSLPVRFQGQVRGLCGNYNGDPTDDFLTPDSEQAPDAVEFASSWKLDDGDYLCEDGCQENCPACTPEQAQLYEDSRFCGMLTQLNGPFAACHEALDPQPFLKECVYDLCVVNGDRASLCRGLSAYTQACLELGISVGNWRSSANCPLSCPANSRYELCAPACQASCNPDAAPSNCSARQCVEGCVCLEGFVESGGACVAASSCGCIYEGRPLAPGQEVWADTTCQRRCTCDAATGQVRCSDTQGCPKGERCLVQNGLRGCYPDRFGTCKGSGDPHYVSFDGRRFDFMGTCTYLLAGSCGQASGLQTFRVLVENEHRGSQTVSYTRAVRVEARGVKVAVRREYPGRVLVDDILQYLPFQAADGQVQVFRQGQNAVIRTDFGLTVTYNWDAHVTVKVPTSYAGALCGLCGNFNEDPADDFALKSGGQAANALAFGNSWQEETRPGCGAAQPGDCPKLDSLVAEQLQSKKECGILADPSGPFRECHRTLDPQGAVRDCVYDRCLLPGQSGPLCDALAAYADACQAAGLTVHPWRSEELCPLSCPSHSHYEECSYGCPLSCGDLPVSGGCGFECKEGCVCDEGFVLNGESCVPLASCGCVYQGSYYPPEQTFYPGPECDSLCYCEEGGLVSCVPSSCGPHEACQPSNGVLGCVAVGSTTCQASGDPHYTTFDGQRFDFMGTCVYVLAQTCGTRPGLPQFAVLQENVAWGNGKVSVTKAITVQVANFTLRLEQNQWKVTVNGVDRRLPVLLDEGRIHVFQHGSDVVIETDFGLRVAYDLVYNVRVTVPGNYYQQLCGLCGNYNGNPKDDFQKPDGSQAGSANEFGNSWEEAVPDSPCLPPPTCQPGDKDCDTELECKPELQNKYEQQEFCGLLTSPTGPLAACHKLLDPQGPLQDCVFDLCVGGGNESILCSNIHAYVSACQAAGGHVEPWRTESFCPMQCPPNSHYEVCADTCSLGCSALSAPPQCPERCAEGCQCDSGFLSDGQGCVPIQECGCYHNGIYYEPEKVVLTDNCQQQCVCQPGKGLVCQNHSCSDGQVCQPSGGVLSCVTKDPCHSVTCRPQETCQNKNGQGVCVPNYQATCWLWGDPHYHSFDGWNFDFQGTCNYVLASTDCPGSNAQGLTPFTVTTKNENRGNPSVSYVRLVTVTTLNTNISIHKGEIGKVRVNGVLRALPVSVADGRLLVTHGASKAVLATDFGLQVTYDWDWRVEVTLPSSYHSAICGLCGNMDRNPSNDQAFPNGTLAPSIPIWGGSWRVPGWDPLCWDECQGSCPTCAEDRLEEYGGPGFCGPLAPGSGGPFAACHDHVAPDSFFKGCVLDVCLGGGAKDILCQALAAYAAACQAAGIVIKDWRTEAGCELPCPENSHYELCGPPCPASCPSPTPPTSPAVCEGPCVEGCQCNSGFVLSADRCVPLEGGCGCWANGIYHEAGSEFWADATCSQRCQCGPRGGSLVCKPASCRLGEECALLPSGQHGCQPVSTAECQAWGDPHYITLDGHRFDFQGACEYLLSAPCHDLPEGALNFTVTVANEHRGSQAVSYTRTVTLHIYGHSFTLSAGWPRQLQVDGKLVALPFQLDSRVHAYLSGADVVVTTASGISLAFDGNSNVRLRVPAAYAGALCGLCGNYNKNPNDDLNAVEGNPDRWQVGGAAGCGECVPGPCPKPCTPEQQEPFGGPDACGVISSLEGPLAPCHSLIPPEQYFQACLLDACQAQGHPGGLCPAVAAYVAACQAAGAQLGEWRRPDFCPFQCPAHSHYQLCGDSCPVSCPSLSAPEGCESTCREGCVCDAGFVLSGDTCVPVGQCGCLHEGRYYPLGETFYPGPECGRHCQCGPGGQVSCQEGETCRPYEECRVQDGVQACRPTGCGRCLANGGVHYITLDGRVYDLHGSCSYILAQVCHPQPGDEDFTIVLEKNAAGDPQRVVVTVAGQVVTLARGPQVTVDGEAVALPVAVGHVRVTAEGRNIVLQTTKDLRLLFDGDAHILISIPSPFRNRLCGLCGNFNGNWNDDLDLPSGTTAPSVDAFGAAWRAPGSSQGCSEGCGPQGCPVCSAEQTAPYESLEACGQLRDANGPFSACHAALSPSEYFRQCVYDLCAQKGNVTYLCRSLAAYTAACQAAGMAVKPWRTDSFCPLQCPTNSHYSVCTRSCQGSCAALSGLTGCTTRCFEGCECDDRFLLSQGVCIPVQDCGCTHDGRYLPVNSSLLTSDCSQRCSCSSSTGLTCQAASCPLGRVCEVQAGTRDCWVPHGLCSLSVGANLTTFDGAHSAVSSPGVYEISFRCPGSQETVPWYRVVADVQPCKGKVEAVARVHIFFQDGLVTVTQNKGVWVNGLQVDLPAEVLTSVSVSQNPDGSVLVQQKEGVQVKLGADGQLAVVVSDDHAGKLCGACGNFDADWSNDWPNSQETTLENWKAQDFSPCQD", "length": 3001, "header": "tr|A0AAA9SGY6-1|A0AAA9SGY6_BOVIN Isoform 1 of Fc gamma binding protein OS=Bos taurus OX=9913 GN=FCGBP PE=1 SV=1 CANONICAL=A0AAA9SGY6-1" }, "locus": { "chromosome": "18", "start_pos": 49449999, "end_pos": 49408384, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091331.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091331.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081765.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1970, "start_aa": "Thr", "end_pos": 1970, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1970", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZQD3-1", "protein_name": "Mucin-2", "gene_name": "Fcgbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNPGHGSSFESTLDKKKKISSSLALVTFQVLSSHRGSVAPLSTTGKGERESARHHRVFCGTAWADMAAIWRSNYGMGSPWSWWALWAGAILLWARLTPTEASCQGVQCASGQRCQMVSGKARCVAESTAVCRAQGDPHYTTFDGRRYDMMGSCSYTMAELCGSDETLPAFSVEAKNEHRGSRQVSYVGLVTVYAYSHSVSMVRGETGFIRIDNQRSRLPASLSEGRLRVYQSGTRGIIELDFGLVISYDWDSQLTLSLPKRFQDQVCGLCGNYNGDPADDFLTPDLEQAPNALEFANSWKLDDGDYLCDDGCHNSCPSCTPGQMQHYKGDRLCGMLALSTGPFSACHELLDPKPFLEDCVFDLCVTGGERLSLCRSLSAYAQACVELGVTLENWRQPSNCPMSCPANSCYDPCSPACPASCNSEALPSNCSSRPCVEGCVCLPGFVASGGDCVPVSSCGCTYQGRPLAPGQEVFADDQCQRRCTCDGATQKVTCRDTSGCPSGEHCNVQNGLLGCYPDNFASCQASGDPHYVSFDGKRFDFMGTCTYLLVGSCGQNAALPAFKVLVENEHRGSQTVSYTRAVRVVAHGVEVAVRRENPGRVLVDGVLQYLPFQAAGGKVRVYRQGNDAVVSTDFGLTVTYNWDAHVTAKVPNSYAKAVCGLCGNFNGNPDDDLALKGGGQANNVLDFGNSWQEEIIPGCGATTPGDCPQLDSLVTQQTQSKKECGILADPEGPFRECHKLLNPQGAIRDCVYDLCLLPGQSGPLCEALAAYAAECQAAGGTVHPWRSEKLCPLTCPPNSHYELCSYGCPLSCGDLPVPGGCGSECRESCVCDEGFALSGESCVPLASCGCVYQGAYHSPGETFYPGPGCESLCHCEEGGLVSCEPSSCGPHEACQPSNGVLGCVAVGTTTCQASGDPHYITFDGRRFDFMGTCVYVLAQTCGTRPGLHQFTVLQENEPWGNGKVSVTKVITVLVANYTLRLEQNQWKVKVNGVDMKLPVVLDGGKIRVSQHGSDAVIETDFGLRVAYDLVYSVRVTIPGNYYQQMCGLCGDYNGDPKDDFQKPDGSQATNPSDFGNSWEEAVPDSPCAPVPPCTGDDCNPACSPELENKYSGEKFCGLLTNPTGPLAACHKLLDPQGPLKDCVFDLCLGGGNQSILCNNIHAYVSACQEAGGQVEPWRTETFCPMKCPPHSHYEVCADTCSLGCWALSTPQKCPEVCAEGCECDSGFLYNGKACVPIQECGCYHNGVYYEPEESVLIENCQQHCVCHPGTGMVCQDHSCKPGEVCEPSGGVLTCITKDPCHGITCRPQETCKVEGGEGVCVPNYHATCWLWGDPHYNSFDGWSYDFQGTCNYLLAGTICPGINAEGLTPFTVTTKNENRGNPAVSYVRLVTVTTLNTNISIHKNEIGKVRVNGALVTLPVYLAGGRISVINGGSKAVLETDFGLQVTYDWNWRVEVTLPSSYHSAVCGLCGNMDKKPENDKVFPNGTVAPSIPAWGGSWQVPGWDPLCWNECQGSCPTCPEDRVEEYEGPGFCGPLAPGTGGPFASCHSHVPPESFFKGCVLDVCLGGGNKDILCQALAAYAAACQAAGIKIEDWRTQAGCEIPCPDNSHYELCGPRCPASCPPPAQHTPPTACDGPCVEGCQCDQGFVLSADQCVPLDGGCGCWVNGTYHEAGTEFWTDTTCSKRCHCGPGGDSLICKSASCGLGEECALLPSGEIGCQPTSIAECEAWGDPHYTTLDGHRFDFQGTCEYLLSAPCHAPPPGIEYFNVTVANEHRGSQAVSYTRSVTLHIYGLSLTLSAQWPRQLQVNGEFVALPFHLDQKLSVYISGADVVVNTASGLSLAFDGNSFVRLRVPAAYAGSLCGLCGNYNKNPNDDLTAVDGKPEGWKVGGAPGCDQCQPEPCPQPCTPEQQEPFRGPDACGIITAPEGPLAPCHSLVPPTKYFEACLLDACQVQGHPGGLCPAIATYVAACQAAGAQLGEWRKPDFCPLQCPANSHYQLCGDSCPVSCPSLSAPEGCETTCREGCVCDSGFVLSGDTCVPVGQCGCLYNGRYYVLGATFYPGPECERLCECGPGGQVTCQEGADCEPYEECRVENGVQACHPTGCGHCLANGGVHYVTLDGRVYDLHGSCSYVLAGVCRPKPGEEEFSIVLEKDSAGEPQRVVVTVADQVVVLARGPQVTVDGEAVALPVATAHVSVTAEGRNVVLQTNKGMKVLFDGDAHILMSIPSSFRGRICGLCGNFNGNWSDDFVLPGGAVAPNVDAFGAAWRAPSSSLGCSEGCGPQGCPVCLAEETEAYEKNDACGKIRDPKGPFATCHKVLSPLEYFRQCVYDMCAHKGDKAYLCRSLAAYTAACQASGAAVKPWRTDSFCPLQCPAHSHYSVCTRSCQGSCAALSGLTGCTTRCFEGCECDDHFLLSQGVCIPAQDCGCVHNGQYVPVNSSLMSSDCSELCYCSETTGLTCRAAGCPSGQVCEIQAGVRQCRAAHGLCSLSVGANLTTFDGALNTISSPGVYELSSRCPGFQKNVPWYRLLADVQPCLNNDKIVSKVHIFFQDGMVTVIPSKGAWVNGLRVDLPATVLTSVSVKKMPDGSMFVHQKAGVQVWLGKDGHLDVMVGDDHAAVLCGVCGNFDGDQTNDAHGSQGKTTIEKWRAQDFSPCPN", "length": 2658 }, "evidence": [ { "id": "A0AAA9SGY6", "url": "https://omabrowser.org/oma/group/A0AAA9SGY6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q9C6-1", "protein_name": "Mucin-2", "gene_name": "Fcgbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSPWKWWALWAGATLLWALLTPAEASCQGIQCASGQRCQMVSGKARCVAESTAVCRAQGDPHYTTFDGRRYDMMGTCSYTMAELCGSDETLPAFSVEAKNEHRGSRQVSYVGLVTVYAYSHSVSLVRGEIGFVRIDNQRSRLPASLSEGRLRVHKSGTRGVIEMDFGLVVTYDWDGQLTLSLPKRFQDQVCGLCGNYNGDPADDFLTPDLDQAPDALEFANSWKLDDGDYLCDDGCHNSCPSCTPGQTQHYKGDRLCGMLTLSTGPFSACHEFLDPKPFLDDCVFDLCVTGGERLSLCRSLSAYAQACVELGVTLENWRLPASCPMSCPANSCYDPCSPACPPSCNSEAVPTNCSSRPCVEGCVCLPGFVASGGDCVPVSSCGCIYQGRLLAPGQEVFDDDRCRRRCTCDGATQKVTCRDTTGCPSGERCNVQNGLLGCYPDNFASCQASGDPHYVSFDGKRFDFMGTCTYLLVGSCGQNAALPAFKVLVENEHRGSQTVSYTRAVRVVAHGVEVAVRRENPGRVLIDGVLQYLPFQAAGGKIQVYRQGNDAIVSIDFGLTVTYNWDAHVTAKVPSSYAKDVCGLCGNFNGNPDDDLALKGGGQASNVLDFGNSWQEEIIPGCGATEPGDCPQLDSLVTQQIQDKKECGILADPEGPFRECHKLLNPQGAIRDCVYDLCLLPGQSGPLCDALAAYAAACQAAGGTVHPWRSEELCPLTCPPNSHYEQCSYGCPLSCGDLPVQGGCGSECREGCVCNEGFALSGESCVPLASCGCVHEGAYHAPGETFYPGPGCDSLCHCEEGGLVSCEPSSCGPQEACQPSNGVLGCVAVGTTTCQASGDPHYVTFDGRRFDFMGTCVYVLAQTCGNRPGLHQFTVLQENEAWGNGKVSVTKVITVLVANYTLRLEQSQWKVKVNGVDTKLPVMLDGGKIRVSQHGSDVVIETDFGLRVAYDLVYYVRVTIPGNYYKQMCGLCGDYNGDPKDDFQKPDGSQTTDPSDFGNSWEEAVPDSPCAPVPPCTGDDCDTECSPELQDKYHGEQFCGLLTSPTGPLAACHKLLDPQGPLQDCVFDLCLGGGNQSILCNIIHAYVSACQAAGGQVEPWRTETFCPMECPPHSHYEVCADTCSLGCWALNTPQQCPEGCAEGCECDSGFLYNGKACVPIEQCGCYHNGVYYEPEESVLIENCQQHCVCQPGKGMMCQDHSCKPGQVCEPSGGVLTCVTKDPCHGITCRPQETCKVQGGEGVCVPNYNSTCWLWGDPHYNSFDGWSFDFQGTCNYLLAGTLCPGVNAEGLTPFTVTTKNENRGSPAVSYVRQVTVTTLNTNISIHKNEIGKVRVNGVLMALPVYLAGGRISVINGGSKAVLETDFGLQVTYDWNWRVDVTLPSSYHGAVCGLCGNMDKNHQNDQVFPNGTMAPSIPTWGGSWQVPGWDPLCWHECQGSCPTCPEDRVEEYEGPGFCGPLAPGTGSPFTSCHAHVPPESFFKGCVLDVCLGGGSKDILCQALAAYAAACQAAGIKIEDWRTQAGCEITCPDNSHYELCGPPCPASCPPPARHTAPTVCDGPCVEGCQCDEGFVLSADQCVPLDGGCGCWVNGTYYEAGTEFWADTTCSKRCHCGPGGDSLVCKPASCGLGEECALLPSGEIGCQPTSITECQAWGDPHYTTLDGHRFDFQGTCEYLLSAPCHEPPTGTEYFNVTVANEHRGSQAVSYTRSVTLQIYGLSLTLSAQWPRKLQVNGEFVALPFHLDQKLSVYISGADVVVNTASGVSLAFDGDSFVRLRVPAAYAGTLCGLCGNYNKNPNDDLTAVGGKPEGWKVGGAPGCDQCEPEPCPKPCTPEEQEPFRGPDACGIITAPEGPLAPCHSLVPPTQYFEACLLDACQVQGHPGGLCPAIATYVAACQAAGAQLGEWRKPDFCPLQCPAHSHYQLCGDSCPVSCPSLSAPVGCETICREGCVCDAGFVLSGDTCVPVGQCGCLYQGRYYVLGATFYPGPECERLCECGPDGQVTCQEGADCEPYEECRIENGVQACHPTGCGHCLANGGLHYVTLDGRVYDLHGSCSYVLASVCHPKPGDEEFSIVLEKNSAGDPQRVVVTVAGQVVGLARGPQVTVDGEVVTLPVATGHVSVTAEGRNIVLQTNKGMKVLFDGDAHILMSIPSSFRGRLCGLCGNFNGNWSDDFVLPSGAVAPNVEAFGTAWRAPGSSLGCGEGCGPQGCPVCLAEETQAYEKNDACGKIRDPHGPFAACHKVLSPLEYFRQCVYDMCAHKGDKAYLCRSLAAYTAACQAAGAAVKPWRTDSVCPLQCPAHSHYSICTRSCQGSCAALSGLTGCTTRCFEGCECDDHFLLSHGVCIPAQDCGCVHNGQYMPVNSSLMSSDCSERCFCSPNNGLTCHEAGCPSGHVCEIQAGVRECQAARGLCSISVGANLTTFDGAHNAISSPGVYELSSRCPGLQKNVPWYRVLADVQPCHNNDKIVSKVHIFFQDGLVTVIPSKGAWVNGLRVDLPATVLTSVSVRRMPDGSMLVHQKAGVTVWLGKDGLLDVMVGDDLAAMLCGACGNFDGDQTNDAYGSQGKTPIEKWRAQDFSPCSN", "length": 2583 }, "evidence": [ { "id": "A0AAA9SGY6", "url": "https://omabrowser.org/oma/group/A0AAA9SGY6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1316, "end_pos": 1318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1496, "end_pos": 1498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1620, "end_pos": 1622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1742, "end_pos": 1744, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1829, "end_pos": 1831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2110, "end_pos": 2112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2683, "end_pos": 2685, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2783, "end_pos": 2785, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2839, "end_pos": 2841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 769, "end_pos": 771, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY6" }, { "id": "PS51233", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51233" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFD", "eco_id": "ECO_0000259", "start_pos": 469, "end_pos": 649, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1970 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1316, "end_pos": 1318 }, { "start_pos": 1496, "end_pos": 1498 }, { "start_pos": 1620, "end_pos": 1622 }, { "start_pos": 1742, "end_pos": 1744 }, { "start_pos": 1829, "end_pos": 1831 }, { "start_pos": 192, "end_pos": 194 }, { "start_pos": 208, "end_pos": 210 }, { "start_pos": 2110, "end_pos": 2112 }, { "start_pos": 2683, "end_pos": 2685 }, { "start_pos": 2783, "end_pos": 2785 }, { "start_pos": 2839, "end_pos": 2841 }, { "start_pos": 769, "end_pos": 771 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGZ0-1", "uniprot_ac": "A0AAA9SGZ0", "uniprot_id": "A0AAA9SGZ0_BOVIN", "mass": { "chemical_mass": 58027.0, "monoisotopic_mass": 58027.0 }, "refseq": { "ac": "XP_024846758", "name": "glucocorticoid-induced transcript 1 protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846758" }, "gene_names": [ { "name": "GLCCI1", "type": "recommended", "evidence": [ { "id": "A0AAA9SGZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0" } ] }, { "name": "GLCCI1", "type": "synonym", "evidence": [ { "id": "XP_024846758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846758" } ] } ], "protein_names": [ { "name": "Glucocorticoid induced 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SGZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0/entry#names_and_taxonomy" } ] }, { "name": "glucocorticoid-induced transcript 1 protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024846758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846758" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGZ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLCCI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0", "locus": { "chromosome": "4", "start_pos": 16156702, "end_pos": 16051322, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008533", "url": "https://www.ensembl.org/id/ENSBTAG00000008533" } ] } } ], "crossref": [ { "id": "A0AAA9SGZ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGZ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "541048", "url": "https://www.ncbi.nlm.nih.gov/gene/541048", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541048", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541048", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14972:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14972:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846758", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846758", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGZ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTAASSSSSSQTPHPPPQRMRRSAAGSPPAAPAAGSGNGAGGGGGGGVGCAPAAGAGRLLQPIRATVPYQLLRGSQHSPTRPPAAAAAASLGSLPGPGAARGPSPPSPTPPPAAAPTEQAPRAKGRPRRSPESHRRSNSPERRSPGSPVCRVDRPKSQQVRTSSTIRRTSSLDTITGPYLTGQWPRDPHVHYPSCMKDKATQTPSCWAEEGAEKRSHQRSASWGSADQLKEQIAKLRQQLQRSKQSSRHSKEKDRQSPLHGNHIAISHTQATGSRSVPMPLSNISVPKSSVSRVPCNVEGISPELEKVFIKENNGKEDVSKPLDIPDGRRAPLPAHYRSSSTRSIDTQTPSVQERSSSCSSHSPCVSPFCPPESQDGSPCSTEDLLYDRDKDSGSSSPLPKYASSPKPNNSYMFKREPPEGCERVKVFEEMASRQPISAPLFSCPDKNKVNFIPTGSAFCPVKLLGPLLPASDLMLKNSPNSGQSSALATLTVEQLSSRVSFTSLSDDTSIAGSAEASVQQPSQQQQFLQELPGEDHMSAHNYVVI", "length": 547, "header": "tr|A0AAA9SGZ0-1|A0AAA9SGZ0_BOVIN Isoform 1 of Glucocorticoid induced 1 OS=Bos taurus OX=9913 GN=GLCCI1 PE=4 SV=1 CANONICAL=A0AAA9SGZ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ0/entry#A0AAA9SGZ0-1", "sequence": { "sequence": "MSTAASSSSSSQTPHPPPQRMRRSAAGSPPAAPAAGSGNGAGGGGGGGVGCAPAAGAGRLLQPIRATVPYQLLRGSQHSPTRPPAAAAAASLGSLPGPGAARGPSPPSPTPPPAAAPTEQAPRAKGRPRRSPESHRRSNSPERRSPGSPVCRVDRPKSQQVRTSSTIRRTSSLDTITGPYLTGQWPRDPHVHYPSCMKDKATQTPSCWAEEGAEKRSHQRSASWGSADQLKEQIAKLRQQLQRSKQSSRHSKEKDRQSPLHGNHIAISHTQATGSRSVPMPLSNISVPKSSVSRVPCNVEGISPELEKVFIKENNGKEDVSKPLDIPDGRRAPLPAHYRSSSTRSIDTQTPSVQERSSSCSSHSPCVSPFCPPESQDGSPCSTEDLLYDRDKDSGSSSPLPKYASSPKPNNSYMFKREPPEGCERVKVFEEMASRQPISAPLFSCPDKNKVNFIPTGSAFCPVKLLGPLLPASDLMLKNSPNSGQSSALATLTVEQLSSRVSFTSLSDDTSIAGSAEASVQQPSQQQQFLQELPGEDHMSAHNYVVI", "length": 547, "header": "tr|A0AAA9SGZ0-1|A0AAA9SGZ0_BOVIN Isoform 1 of Glucocorticoid induced 1 OS=Bos taurus OX=9913 GN=GLCCI1 PE=4 SV=1 CANONICAL=A0AAA9SGZ0-1" }, "locus": { "chromosome": "4", "start_pos": 16155698, "end_pos": 16051521, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131411.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131411.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084598.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084598.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 110, "start_aa": "Thr", "end_pos": 110, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr110", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:541048", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541048", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 110 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 284, "end_pos": 286 }, { "start_pos": 410, "end_pos": 412 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH71-1", "uniprot_ac": "A0AAA9SH71", "uniprot_id": "A0AAA9SH71_BOVIN", "mass": { "chemical_mass": 10019.0, "monoisotopic_mass": 10019.0 }, "refseq": { "ac": "XP_059733550", "name": "small cysteine and glycine repeat-containing protein 7-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733550" }, "gene_names": [ { "name": "LOC132342861", "type": "recommended", "evidence": [ { "id": "A0AAA9SH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71" } ] }, { "name": "LOC132342861", "type": "synonym", "evidence": [ { "id": "XP_059733550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733550" } ] } ], "protein_names": [ { "name": "Small cysteine and glycine repeat containing 8", "type": "synonym", "evidence": [ { "id": "A0AAA9SH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71/entry#names_and_taxonomy" } ] }, { "name": "small cysteine and glycine repeat-containing protein 7-like", "type": "synonym", "evidence": [ { "id": "XP_059733550", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733550" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132342861", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71", "locus": {} } ], "crossref": [ { "id": "A0AAA9SH71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH71", "database": "AlphaFoldDB", "categories": [] }, { "id": "132342861", "url": "https://www.ncbi.nlm.nih.gov/gene/132342861", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "XP_059733550", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SH71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCCGCGSCGGCGGGCGSGCGGGCGGGCGGGCGSCNSCRCYRVGCCTSCCPCCYGCCGGCCSVPVVCCHRRTCSCNSCGCGGGKGCCQQKSCCQQKCSCQKQCCH", "length": 105, "header": "tr|A0AAA9SH71-1|A0AAA9SH71_BOVIN Isoform 1 of Small cysteine and glycine repeat containing 8 OS=Bos taurus OX=9913 GN=LOC132342861 PE=4 SV=1 CANONICAL=A0AAA9SH71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH71/entry#A0AAA9SH71-1", "sequence": { "sequence": "MGCCGCGSCGGCGGGCGSGCGGGCGGGCGGGCGSCNSCRCYRVGCCTSCCPCCYGCCGGCCSVPVVCCHRRTCSCNSCGCGGGKGCCQQKSCCQQKCSCQKQCCH", "length": 105, "header": "tr|A0AAA9SH71-1|A0AAA9SH71_BOVIN Isoform 1 of Small cysteine and glycine repeat containing 8 OS=Bos taurus OX=9913 GN=LOC132342861 PE=4 SV=1 CANONICAL=A0AAA9SH71-1" }, "locus": { "chromosome": "2", "start_pos": 115886049, "end_pos": 115885735, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091574.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091574.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083261.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH80-1", "uniprot_ac": "A0AAA9SH80", "uniprot_id": "A0AAA9SH80_BOVIN", "mass": { "chemical_mass": 26977.0, "monoisotopic_mass": 26977.0 }, "refseq": {}, "gene_names": [ { "name": "MRPL22", "type": "recommended", "evidence": [ { "id": "A0AAA9SH80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL22m", "type": "recommended", "evidence": [ { "id": "A0AAA9SH80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L22, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAA9SH80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80", "locus": { "chromosome": "7", "start_pos": 66144328, "end_pos": 66104075, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019457", "url": "https://www.ensembl.org/id/ENSBTAG00000019457" } ] } } ], "crossref": [ { "id": "A0AAA9SH80", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH80", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00336", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00336", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614639", "url": "https://www.ncbi.nlm.nih.gov/gene/614639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13501", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13501", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13501:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13501:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SH80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJC7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJC7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXI7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXI7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYD8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYD8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRPFSLPEPQFPHLWRGGVARHALLAPSGNAVSAGALWVQNLRGKLALGLFSSHSILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 236, "header": "tr|A0AAA9SH80-1|A0AAA9SH80_BOVIN Isoform 1 of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=3 SV=1 CANONICAL=A0AAA9SH80-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80/entry#A0AAA9SH80-1", "sequence": { "sequence": "MNRPFSLPEPQFPHLWRGGVARHALLAPSGNAVSAGALWVQNLRGKLALGLFSSHSILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 236, "header": "tr|A0AAA9SH80-1|A0AAA9SH80_BOVIN Isoform 1 of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=3 SV=1 CANONICAL=A0AAA9SH80-1" }, "locus": { "chromosome": "7", "start_pos": 66144241, "end_pos": 66104180, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105575.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105575.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085568.1" } ] } }, { "isoform_ac": "A0ABI0NJC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80/entry#A0ABI0NJC7-1", "sequence": { "sequence": "MEISRQEYWSALWVQNLRGKLALGLFSSHSILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 210, "header": "tr|A0ABI0NJC7-1|A0ABI0NJC7_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=3 SV=1 CANONICAL=A0AAA9SH80-1" }, "locus": { "chromosome": "7", "start_pos": 66144241, "end_pos": 66104810, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139172.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139172.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104209.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104209.1" } ] } }, { "isoform_ac": "A0ABI0NXI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80/entry#A0ABI0NXI7-1", "sequence": { "sequence": "MKHEPIQLTTGSIRLFSSHSILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 200, "header": "tr|A0ABI0NXI7-1|A0ABI0NXI7_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=3 SV=1 CANONICAL=A0AAA9SH80-1" }, "locus": { "chromosome": "7", "start_pos": 66144241, "end_pos": 66126028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142433.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142433.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104758.1" } ] } }, { "isoform_ac": "A0ABI0NYD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80/entry#A0ABI0NYD8-1", "sequence": { "sequence": "MAAVILERLGALWVQNLRGKLALGLFSSHSILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 210, "header": "tr|A0ABI0NYD8-1|A0ABI0NYD8_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=3 SV=1 CANONICAL=A0AAA9SH80-1" }, "locus": { "chromosome": "7", "start_pos": 66144241, "end_pos": 66108806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149628.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149628.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105268.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80" } ], "pmid": "" }, { "name": "large ribosomal subunit", "id": "GO:0015934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015934", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH84-1", "uniprot_ac": "A0AAA9SH84", "uniprot_id": "A0AAA9SH84_BOVIN", "mass": { "chemical_mass": 69941.0, "monoisotopic_mass": 69941.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112442379", "type": "recommended", "evidence": [ { "id": "A0AAA9SH84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" } ] } ], "protein_names": [ { "name": "Cationic amino acid transporter C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SH84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112442379", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84", "locus": {} } ], "crossref": [ { "id": "A0AAA9SH84", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH84", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SH84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTMLGQYLRQFGQKLVRRKPQFREEPESSETPPPNTLDLVVIGLDNMLGAGIYILIGGVAKYIAGPAIILFLLVAGLTTLLSGLCYVELAAGVEKPGTVYFISYVTMGQLYAFITGWNLLLYLIIAIACIARAWSSIFDSLIGNHISEALEGTFSLQMPYFLASFPDFLALGLVLLLTGLLALRVYESTLIYKVFTGLNILVLSFIILSGFIKGDLHNWKLTEQDYTLAAAGSGDAYSLGLLGSGGFLPFAFDGILQGAATCFYAFVGFAGIVNAGRKASNPQWSMPLAVMISFFICFLVCFGVSAALTLMVPYYLIQLESPLPQAFIYVGWNSAKYVVAVGTLSILLYSLLSIMFIMSQLTYAMAEDGLLFRGLAWIPAHTDAHTIIIRTTYARIIVHTVAPTGTPIMAVLVPGTLAAVMALLFDFTDLVDLMSFQSLVAHSLVTFSVLVLRYQPAQNGSKKEKTEEETETKPEVEGGPLESEPEAGTSNILQSLWFPPSTIPTRKSGQIVYGCASLVVLLLIILSLILYRWSSQVFSGDPVLTTVALLLLLLITGVTLIIWRQPQNPSTLPFRVPALPALFLVSTFMNVYLMIQMTTRTWAQFGIWMAIGFAIYFGYGIQHSLGENNDQQPAASTSQT", "length": 641, "header": "tr|A0AAA9SH84-1|A0AAA9SH84_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442379 PE=3 SV=1 CANONICAL=A0AAA9SH84-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84/entry#A0AAA9SH84-1", "sequence": { "sequence": "MSTMLGQYLRQFGQKLVRRKPQFREEPESSETPPPNTLDLVVIGLDNMLGAGIYILIGGVAKYIAGPAIILFLLVAGLTTLLSGLCYVELAAGVEKPGTVYFISYVTMGQLYAFITGWNLLLYLIIAIACIARAWSSIFDSLIGNHISEALEGTFSLQMPYFLASFPDFLALGLVLLLTGLLALRVYESTLIYKVFTGLNILVLSFIILSGFIKGDLHNWKLTEQDYTLAAAGSGDAYSLGLLGSGGFLPFAFDGILQGAATCFYAFVGFAGIVNAGRKASNPQWSMPLAVMISFFICFLVCFGVSAALTLMVPYYLIQLESPLPQAFIYVGWNSAKYVVAVGTLSILLYSLLSIMFIMSQLTYAMAEDGLLFRGLAWIPAHTDAHTIIIRTTYARIIVHTVAPTGTPIMAVLVPGTLAAVMALLFDFTDLVDLMSFQSLVAHSLVTFSVLVLRYQPAQNGSKKEKTEEETETKPEVEGGPLESEPEAGTSNILQSLWFPPSTIPTRKSGQIVYGCASLVVLLLIILSLILYRWSSQVFSGDPVLTTVALLLLLLITGVTLIIWRQPQNPSTLPFRVPALPALFLVSTFMNVYLMIQMTTRTWAQFGIWMAIGFAIYFGYGIQHSLGENNDQQPAASTSQT", "length": 641, "header": "tr|A0AAA9SH84-1|A0AAA9SH84_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442379 PE=3 SV=1 CANONICAL=A0AAA9SH84-1" }, "locus": { "chromosome": "18", "start_pos": 61111263, "end_pos": 61105377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090403.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090403.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084692.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084692.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH84" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 575, "end_pos": 625, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 460, "end_pos": 462 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH86-1", "uniprot_ac": "A0AAA9SH86", "uniprot_id": "A0AAA9SH86_BOVIN", "mass": { "chemical_mass": 63088.0, "monoisotopic_mass": 63088.0 }, "refseq": {}, "gene_names": [ { "name": "TAF15", "type": "recommended", "evidence": [ { "id": "A0AAA9SH86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ] } ], "protein_names": [ { "name": "TATA-box binding protein associated factor 15", "type": "synonym", "evidence": [ { "id": "A0AAA9SH86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAF15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86", "locus": { "chromosome": "19", "start_pos": 14542740, "end_pos": 14573167, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006916", "url": "https://www.ensembl.org/id/ENSBTAG00000006916" } ] } } ], "crossref": [ { "id": "A0AAA9SH86", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH86", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006916", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006916", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12535", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12535", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BGX1", "url": "https://www.orthodb.org/?gene=E1BGX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23238", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23238", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73776", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73779", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75953", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76042", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T374", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T374", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T374-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T374-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGX1", "url": "https://www.uniprot.org/uniprotkb/E1BGX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BGX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDSGSYGQSGGEQQSYSSYGNQSNQGYGQAPQSYPGYGQTTEPSYGQNYSGYSSYGQSQSGYSQSYSGYENQKQSSYSQQSYNNQGQQNVESSGGQGGRAPSYDQSDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYNQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRPDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGADRSGGGYGGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGNYGGDRGGGYGGDRSGGYGGDRGGSYGGDRSGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSGGGYGGDRGGSGGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY", "length": 605, "header": "tr|A0AAA9SH86-1|A0AAA9SH86_BOVIN Isoform 1 of TATA-box binding protein associated factor 15 OS=Bos taurus OX=9913 GN=TAF15 PE=3 SV=1 CANONICAL=A0AAA9SH86-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86/entry#A0AAA9SH86-1", "sequence": { "sequence": "MSDSGSYGQSGGEQQSYSSYGNQSNQGYGQAPQSYPGYGQTTEPSYGQNYSGYSSYGQSQSGYSQSYSGYENQKQSSYSQQSYNNQGQQNVESSGGQGGRAPSYDQSDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYNQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRPDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGADRSGGGYGGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGNYGGDRGGGYGGDRSGGYGGDRGGSYGGDRSGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSGGGYGGDRGGSGGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY", "length": 605, "header": "tr|A0AAA9SH86-1|A0AAA9SH86_BOVIN Isoform 1 of TATA-box binding protein associated factor 15 OS=Bos taurus OX=9913 GN=TAF15 PE=3 SV=1 CANONICAL=A0AAA9SH86-1" }, "locus": { "chromosome": "19", "start_pos": 14572891, "end_pos": 14543298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114545.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114545.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085573.1" } ] } }, { "isoform_ac": "A0AAA9T374-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86/entry#A0AAA9T374-1", "sequence": { "sequence": "MSDSGSYGQSGGEQQSYSSYGNQSNQGYGQAPQSYPGYGQTTEPSYGQNYSGYSSYGQSQSGYSQSYSGYENQKQSSYSQQSYNNQGQQNVESSGGQGGRAPSYDQSDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYNQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRPDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGGYGGDRSGGYGGDRGGSYGGDRSGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSGGGYGGDRGGSGGYGGDRSGGYGGDRGGYGGKMGGRNDYRNDQRNRPY", "length": 538, "header": "tr|A0AAA9T374-1|A0AAA9T374_BOVIN Computationally mapped isoform of TATA-box binding protein associated factor 15 OS=Bos taurus OX=9913 GN=TAF15 PE=3 SV=1 CANONICAL=A0AAA9SH86-1" }, "locus": { "chromosome": "19", "start_pos": 14572891, "end_pos": 14543298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092592.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092592.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090935.1" } ] } }, { "isoform_ac": "E1BGX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86/entry#E1BGX1-1", "sequence": { "sequence": "MSDSGSYGQSGGEQQSYSSYGNQSNQGYGQAPQSYPGYGQTTEPSYGQNYSGYSSYGQSQSGYSQSYSGYENQKQSSYSQQSYNNQGQQNVESSGGQGGRAPSYDQSDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYNQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRPDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDRGGGYGGDRSGGYGGDRGGSYGGDRSGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSGGGYGGDRGGSGGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY", "length": 534, "header": "tr|E1BGX1-1|E1BGX1_BOVIN Computationally mapped isoform of TATA-box binding protein associated factor 15 OS=Bos taurus OX=9913 GN=TAF15 PE=3 SV=4 CANONICAL=A0AAA9SH86-1" }, "locus": { "chromosome": "19", "start_pos": 14572891, "end_pos": 14543298, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009084.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009084.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009084.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009084.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" }, { "id": "R-BTA-73776", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "resource": "Reactome", "description": "RNA Polymerase II Promoter Escape" }, { "id": "R-BTA-73779", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "resource": "Reactome", "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" }, { "id": "R-BTA-75953", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation" }, { "id": "R-BTA-76042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 233, "end_pos": 319, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SH86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH86" }, { "id": "PS50199", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RanBP2-type", "eco_id": "ECO_0000259", "start_pos": 353, "end_pos": 384, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 22, "end_pos": 24 }, { "start_pos": 232, "end_pos": 234 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHD9-1", "uniprot_ac": "A0AAA9SHD9", "uniprot_id": "A0AAA9SHD9_BOVIN", "mass": { "chemical_mass": 341077.0, "monoisotopic_mass": 341077.0 }, "refseq": { "ac": "XP_010807483", "name": "MAX gene-associated protein isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807483" }, "gene_names": [ { "name": "MGA", "type": "recommended", "evidence": [ { "id": "A0AAA9SHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ] }, { "name": "MGA", "type": "synonym", "evidence": [ { "id": "XP_010807483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807483" } ] } ], "protein_names": [ { "name": "MAX gene-associated protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9/entry#names_and_taxonomy" } ] }, { "name": "MAX gene-associated protein isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010807483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807483" } ] } ], "function": [ { "annotation": "Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.", "evidence": [ { "database": "UniProtKB", "id": "E1BKB7", "url": "https://www.uniprot.org/uniprotkb/E1BKB7#function" }, { "database": "UniProtKB", "id": "ARBA00059348", "url": "https://www.uniprot.org/uniprotkb/ARBA00059348#function" }, { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MGA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9", "locus": { "chromosome": "10", "start_pos": 37166996, "end_pos": 37066923, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015138", "url": "https://www.ensembl.org/id/ENSBTAG00000015138" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015138", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015138", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18911", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18911", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20195", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20195", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532556", "url": "https://www.ncbi.nlm.nih.gov/gene/532556", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037935", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037935", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKB7", "url": "https://www.orthodb.org/?gene=E1BKB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11267:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11267:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010807483", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807483", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKB7", "url": "https://www.uniprot.org/uniprotkb/E1BKB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BKB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEKQQIILANQDGGTVPGAAPTFFVILKQPGNGKTDQGILVTNRDACALASSVSSPGKSKGKICLPADCTVGGITVTLDNNNMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNMKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLNSKPQRDGKQKNSSDQEGNSVPSSPGQRVRLTEGEGSEVQLTDLDPLSRGQETSGKGLEKPSLNIKRDFLGFMDIDSALGEVPQLKQEVSESLGNSFEDGSHVTSPLNPNENFNVVIKEEPLDDYEYELGECPEGVTVKQEETDEETDVYSNSDDDPILEKQLKRHNKADNLEADHPSSKWQPNSPSGVAKAKMFKLDAGKMPVVYLEPCAVTKSTVKVSELPDNMLSTSRKDRSLLTELDYLPAYVENSNETGFCLGRESENDLGRHSLDIRVVQKYPSLKEAQWKYPDISDSVNTEKLLDGSKSSVGDSFLGKEDLGRKKTMLKISAAPRTVNANQNAPPNVPGKRGRPRKLKLSKAGRPPKNTGRSLTSTKNTLTGPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTNEESCSLQASAANDPGCRARISQLEKELIEDLKALRHKQVIHPGLQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPFWNLTGANPASPDAGFPFVSRTGKTNDFTKIKGWRGKFHSASASRNEGGNSEGPLKNRSAFCSDKLDEYLENEGKLMETSMGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPSVSRKAKSQNKQATFSGRTKSSYKSILPYPVSPKQKHTPMIPGDKITKNSSSTTSENRVNNLIVPTLDENTFPKQISLRQAHQQQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFQKKSAHRDPVFYDNLGEEQKEEGEEGVKEEEEQLKEKKKRKKLEYTICETEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPMKPLLLPQPEVLSTTVKGKLLTGIKPARAYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEEERQPSPSPSPSFQQQGSCHSSPENCSVKEPASEQQPLKPLTCDLEDDSDKSQEKSWKSSCNEGESASTSYVHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKMDDVSPVQTDALDSVRERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVNGKSYPQAKLLLGQMGALHPANRLAAYITGRLRPSVLDLSTLSTVISKVASNAKVAASRKPRTLLPSTSNSKTASSSGTTTNRPGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVSTPQPLTGPQKFSIRPSPVMVVTPVVSSEPVQVCSSVTAAVTTTTPQVFLENVPAVTPTTALSDVGTKETTYSSGATTAGVVEVSETNTSTLVTPTQSTATLNLIKTTGITTPVASVAFPKSLVASPPTITLPVASTASTSIVVVTTAASSSMVTTPTSSLSSVPIILSGIDGSPPVSQRPENAPQIPVAPPQVSPNTVKRAGPRLLLIPVQQGSPTLRPVPNTQLQGHRMVLQPVRSPSGMNLFRHPNGQIVQLLPLHQLRGSNNQPNLQPVMFRNPGSVMGIRLPTPSKPSETPPSSASPSAFSVVNPVIQAVGSSPAMNVITQAPSLLSSGPNFVSQSGTLTLRISPPEPHSFTSKTASETKITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQHVASLQMKRESQNADQKDETSFLKREQETKKVLQSGEAVEPETNIIKQNSGAAVSEETLNDSLEDRGDHLDEESLIEEGPTAVKPSEHVCSTGSHAGEDYKDVEEEYGIRNHNSSKEKLTVLEVKTISGRASNMTVQSVNNVQLKKLGDVKVEQQKGLDNPEEKSNEFPVISKEESKVEFSGSRVAEQQSNPKPEAKEKECGESLEKDSIKERWRKHLKGPLAQKYVRTSQEGKNETNEQLIKETKTCKENSDVFQQEHSISDLLGKSGTTENARILKTECDSWSRISSPTTFSIVPRRAAKGSKGDGHFQGHLLLSGEQIKPKQEKTGGRSSTDFTVLELEEEDEEDENEKTDDSIDEIVDVVSDYQSEEVDDVEKNNCIEYIEDDEEQVDIETVEELPEEIKIAHMKSTAVHTEILKQPCCTPVSADEKATERSRKAAQVPLKLKPDYWSEKLQKEAEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILTRAFSEIQGLTDQADKLIGQKNLLTRKRNILIRKVSSLSGKTEEVVLKKLEYIYAKQQAVEAQKRKKKMGSDEFDVSPRTSKQQEGASVSSVDLGQMFINNRKGKPLILSRKKDQATENTSPSNTPHTSANIVMTPQGQLLTLKGPLFSGPVVTVSPALLEGDLKPQVASSAVAQSENDDLFMMPRIVNVTSLATEGGLVDMSGSKYPHEVPDGKPPDHLKNTVRSEDNSCEDLGRISSRGNHRDVRMTLGTAQVYLSHKDSGFPQIVDVSSMQEAQEFLPKKISGDTRGSQHKWKESESRRERLKTKESPFHKLKMKDLKDSSIEMELRKVASAIEEAALDPSELLTSMEDEDDTDETLTSLLNEIAFLNQQLNDDSVSLAELPSSLDTEFPGDARRAFISKLPPGNRATFQVGHLETGLKELPDVQGESDSVSPLLLHLEDDDFSENEKQLAEPASEPDVLKIVIDSEIKDPLVSQRKAGDEGKSASGVPAEPESVSSPPVLHMKGGLENSSTDTLWRPMPKLAPLGLKVANPSSDTEGQSLKVMPCLAPVAAKVGSVGHKMNLTGNDQECRESKVMPTLAPVVAKLGNTGASPSSAGK", "length": 3114, "header": "tr|A0AAA9SHD9-1|A0AAA9SHD9_BOVIN Isoform 1 of MAX gene-associated protein OS=Bos taurus OX=9913 GN=MGA PE=4 SV=2 CANONICAL=A0AAA9SHD9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9/entry#A0AAA9SHD9-1", "sequence": { "sequence": "MEEKQQIILANQDGGTVPGAAPTFFVILKQPGNGKTDQGILVTNRDACALASSVSSPGKSKGKICLPADCTVGGITVTLDNNNMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNMKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLNSKPQRDGKQKNSSDQEGNSVPSSPGQRVRLTEGEGSEVQLTDLDPLSRGQETSGKGLEKPSLNIKRDFLGFMDIDSALGEVPQLKQEVSESLGNSFEDGSHVTSPLNPNENFNVVIKEEPLDDYEYELGECPEGVTVKQEETDEETDVYSNSDDDPILEKQLKRHNKADNLEADHPSSKWQPNSPSGVAKAKMFKLDAGKMPVVYLEPCAVTKSTVKVSELPDNMLSTSRKDRSLLTELDYLPAYVENSNETGFCLGRESENDLGRHSLDIRVVQKYPSLKEAQWKYPDISDSVNTEKLLDGSKSSVGDSFLGKEDLGRKKTMLKISAAPRTVNANQNAPPNVPGKRGRPRKLKLSKAGRPPKNTGRSLTSTKNTLTGPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTNEESCSLQASAANDPGCRARISQLEKELIEDLKALRHKQVIHPGLQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPFWNLTGANPASPDAGFPFVSRTGKTNDFTKIKGWRGKFHSASASRNEGGNSEGPLKNRSAFCSDKLDEYLENEGKLMETSMGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPSVSRKAKSQNKQATFSGRTKSSYKSILPYPVSPKQKHTPMIPGDKITKNSSSTTSENRVNNLIVPTLDENTFPKQISLRQAHQQQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFQKKSAHRDPVFYDNLGEEQKEEGEEGVKEEEEQLKEKKKRKKLEYTICETEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPMKPLLLPQPEVLSTTVKGKLLTGIKPARAYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEEERQPSPSPSPSFQQQGSCHSSPENCSVKEPASEQQPLKPLTCDLEDDSDKSQEKSWKSSCNEGESASTSYVHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKMDDVSPVQTDALDSVRERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVNGKSYPQAKLLLGQMGALHPANRLAAYITGRLRPSVLDLSTLSTVISKVASNAKVAASRKPRTLLPSTSNSKTASSSGTTTNRPGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVSTPQPLTGPQKFSIRPSPVMVVTPVVSSEPVQVCSSVTAAVTTTTPQVFLENVPAVTPTTALSDVGTKETTYSSGATTAGVVEVSETNTSTLVTPTQSTATLNLIKTTGITTPVASVAFPKSLVASPPTITLPVASTASTSIVVVTTAASSSMVTTPTSSLSSVPIILSGIDGSPPVSQRPENAPQIPVAPPQVSPNTVKRAGPRLLLIPVQQGSPTLRPVPNTQLQGHRMVLQPVRSPSGMNLFRHPNGQIVQLLPLHQLRGSNNQPNLQPVMFRNPGSVMGIRLPTPSKPSETPPSSASPSAFSVVNPVIQAVGSSPAMNVITQAPSLLSSGPNFVSQSGTLTLRISPPEPHSFTSKTASETKITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQHVASLQMKRESQNADQKDETSFLKREQETKKVLQSGEAVEPETNIIKQNSGAAVSEETLNDSLEDRGDHLDEESLIEEGPTAVKPSEHVCSTGSHAGEDYKDVEEEYGIRNHNSSKEKLTVLEVKTISGRASNMTVQSVNNVQLKKLGDVKVEQQKGLDNPEEKSNEFPVISKEESKVEFSGSRVAEQQSNPKPEAKEKECGESLEKDSIKERWRKHLKGPLAQKYVRTSQEGKNETNEQLIKETKTCKENSDVFQQEHSISDLLGKSGTTENARILKTECDSWSRISSPTTFSIVPRRAAKGSKGDGHFQGHLLLSGEQIKPKQEKTGGRSSTDFTVLELEEEDEEDENEKTDDSIDEIVDVVSDYQSEEVDDVEKNNCIEYIEDDEEQVDIETVEELPEEIKIAHMKSTAVHTEILKQPCCTPVSADEKATERSRKAAQVPLKLKPDYWSEKLQKEAEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILTRAFSEIQGLTDQADKLIGQKNLLTRKRNILIRKVSSLSGKTEEVVLKKLEYIYAKQQAVEAQKRKKKMGSDEFDVSPRTSKQQEGASVSSVDLGQMFINNRKGKPLILSRKKDQATENTSPSNTPHTSANIVMTPQGQLLTLKGPLFSGPVVTVSPALLEGDLKPQVASSAVAQSENDDLFMMPRIVNVTSLATEGGLVDMSGSKYPHEVPDGKPPDHLKNTVRSEDNSCEDLGRISSRGNHRDVRMTLGTAQVYLSHKDSGFPQIVDVSSMQEAQEFLPKKISGDTRGSQHKWKESESRRERLKTKESPFHKLKMKDLKDSSIEMELRKVASAIEEAALDPSELLTSMEDEDDTDETLTSLLNEIAFLNQQLNDDSVSLAELPSSLDTEFPGDARRAFISKLPPGNRATFQVGHLETGLKELPDVQGESDSVSPLLLHLEDDDFSENEKQLAEPASEPDVLKIVIDSEIKDPLVSQRKAGDEGKSASGVPAEPESVSSPPVLHMKGGLENSSTDTLWRPMPKLAPLGLKVANPSSDTEGQSLKVMPCLAPVAAKVGSVGHKMNLTGNDQECRESKVMPTLAPVVAKLGNTGASPSSAGK", "length": 3114, "header": "tr|A0AAA9SHD9-1|A0AAA9SHD9_BOVIN Isoform 1 of MAX gene-associated protein OS=Bos taurus OX=9913 GN=MGA PE=4 SV=2 CANONICAL=A0AAA9SHD9-1" }, "locus": { "chromosome": "10", "start_pos": 37164178, "end_pos": 37075885, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098173.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098173.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081918.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081918.2" } ] } }, { "isoform_ac": "E1BKB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9/entry#E1BKB7-1", "sequence": { "sequence": "MEEKQQIILANQDGGTVPGAAPTFFVILKQPGNGKTDQGILVTNRDACALASSVSSPGKSKGKICLPADCTVGGITVTLDNNNMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNMKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKATEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLNSKPQRDGKQKNSSDQEGNSVPSSPGQRVRLTEGEGSEVQLTDLDPLSRGQETSGKGLEKPSLNIKRDFLGFMDIDSALGEVPQLKQEVSESLGNSFEDGSHVTSPLNPNENFNVVIKEEPLDDYEYELGECPEGVTVKQEETDEETDVYSNSDDDPILEKQLKRHNKADNLEADHPSSKWQPNSPSGVAKAKMFKLDAGKMPVVYLEPCAVTKSTVKVSELPDNMLSTSRKDRSLLTELDYLPAYVENSNETGFCLGRESENDLGRHSLDIRVVQKYPSLKEAQWKYPDISDSVNTEKLLDGSKSSVGDSFLGKEDLGRKKTMLKISAAPRTVNANQNAPPNVPGKRGRPRKLKLSKAGRPPKNTGRSLTSTKNTLTGPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTNEESCSLQASAANDPGCRARISQLEKELIEDLKALRHKQVIHPGLQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPFWNLTGANPASPDAGFPFVSRTGKTNDFTKIKGWRGKFHSASASRNEGGNSEGPLKNRSAFCSDKLDEYLENEGKLMETSMGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPSVSRKAKSQNKQATFSGRTKSSYKSILPYPVSPKQKHTPMIPGDKITKNSSSTTSENRVNNLIVPTLDENTFPKQISLRQAHQQQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFQKKSAHRDPVFYDNLGEEQKEEGEEGVKEEEEQLKEKKKRKKLEYTICETEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPMKPLLLPQPEVLSTTVKGKLLTGIKPARAYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEEERQPSPSPSPSFQQQGSCHSSPENCSVKEPASEQQPLKPLTCDLEDDSDKSQEKSWKSSCNEGESASTSYVHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKMDDVSPVQTDALDSVRERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVNGKSYPQAKLLLGQMGALHPANRLAAYITGRLRPSVLDLSTLSTVISKVASNAKVAASRKPRTLLPSTSNSKTASSSGTTTNRPGKNLKAFVPAKRPIENAPQIPVAPPQVSPNTVKRAGPRLLLIPVQQGSPTLRPVPNTQLQGHRMVLQPVRSPSGMNLFRHPNGQIVQLLPLHQLRGSNNQPNLQPVMFRNPGSVMGIRLPTPSKPSETPPSSASPSAFSVVNPVIQAVGSSPAMNVITQAPSLLSSGPNFVSQSGTLTLRISPPEPHSFTSKTASETKITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQHVASLQMKRESQNADQKDETSFLKREQETKKVLQSGEAVEPETNIIKQNSGAAVSEETLNDSLEDRGDHLDEESLIEEGPTAVKPSEHVCSTGSHAGEDYKDVEEEYGIRNHNSSKEKLTVLEVKTISGRASNMTVQSVNNVQLKKLGDVKVEQQKGLDNPEEKSNEFPVISKEESKVEFSGSRVAEQQSNPKPEAKEKECGESLEKDSIKERWRKHLKGPLAQKYVRTSQEGKNETNEQLIKETKTCKENSDVFQQEHSISDLLGKSGTTENARILKTECDSWSRISSPTTFSIVPRRAAKGSKGDGHFQGHLLLSGEQIKPKQEKTGGRSSTDFTVLELEEEDEEDENEKTDDSIDEIVDVVSDYQSEEVDDVEKNNCIEYIEDDEEQVDIETVEELPEEIKIAHMKSTAVHTEILKQPCCTPVSADEKATERSRKAAQVPLKLKPDYWSEKLQKEAEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILTRAFSEIQGLTDQADKLIGQKNLLTRKRNILIRKVSSLSGKTEEVVLKKLEYIYAKQQAVEAQKRKKKMGSDEFDVSPRTSKQQEGASVSSVDLGQMFINNRKGKPLILSRKKDQATENTSPSNTPHTSANIVMTPQGQLLTLKGPLFSGPVVTVSPALLEGDLKPQVASSAVAQSENDDLFMMPRIVNVTSLATEGGLVDMSGSKYPHEVPDGKPPDHLKNTVRSEDNSCEDLGRISSRGNHRDVRMTLGTAQVYLSHKDSGFPQIVDVSSMQEAQEFLPKKISGDTRGSQHKWKESESRRERLKTKESPFHKLKMKDLKDSSIEMELRKVASAIEEAALDPSELLTSMEDEDDTDETLTSLLNEIAFLNQQLNDDSVSLAELPSSLDTEFPGDARRAFISKLPPGNRATFQVGHLETGLKELPDVQGESDSVSPLLLHLEDDDFSENEKQLAEPASEPDVLKIVIDSEIKDPLVSQRKAGDEGKSASGVPAEPESVSSPPVLHMKGGLENSSTDTLWRPMPKLAPLGLKVANPSSDTEGQSLKVMPCLAPVAAKVGSVGHKMNLTGNDQECRESKVMPTLAPVVAKLGNTGASPSSAGK", "length": 2905, "header": "tr|E1BKB7-1|E1BKB7_BOVIN Computationally mapped isoform of MAX gene-associated protein OS=Bos taurus OX=9913 GN=MGA PE=4 SV=3 CANONICAL=A0AAA9SHD9-1" }, "locus": { "chromosome": "10", "start_pos": 37164178, "end_pos": 37075885, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020143.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020143.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020143.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020143.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1660, "start_aa": "Thr", "end_pos": 1660, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1660", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1662, "start_aa": "Thr", "end_pos": 1662, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1662", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "reported site T1611 is on non-canonical isoform E1BKB7-1 which maps to canonical isoform site A0AAA9SHD9-1:1820", "icn3d_view": {}, "start_pos": 1820, "start_aa": "Thr", "end_pos": 1820, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1820", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2089, "start_aa": "Thr", "end_pos": 2089, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2089", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8953750", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "resource": "Reactome", "description": "Transcriptional Regulation by E2F6" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "cell fate specification", "id": "GO:0001708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001708", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1275, "end_pos": 1277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1691, "end_pos": 1693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2068, "end_pos": 2070, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2121, "end_pos": 2123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2141, "end_pos": 2143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2243, "end_pos": 2245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2632, "end_pos": 2634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2702, "end_pos": 2704, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3025, "end_pos": 3027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3078, "end_pos": 3080, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 815, "end_pos": 817, "annotation": "n_glycosylation_sequon" }, { "start_pos": 938, "end_pos": 940, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 2472, "end_pos": 2523, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHD9" }, { "id": "PS50252", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50252" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "T-box", "eco_id": "ECO_0000259", "start_pos": 79, "end_pos": 260, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1660, 1662, 1820, 2089 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1275, "end_pos": 1277 }, { "start_pos": 1691, "end_pos": 1693 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 2068, "end_pos": 2070 }, { "start_pos": 2121, "end_pos": 2123 }, { "start_pos": 2141, "end_pos": 2143 }, { "start_pos": 2243, "end_pos": 2245 }, { "start_pos": 2632, "end_pos": 2634 }, { "start_pos": 2702, "end_pos": 2704 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 3025, "end_pos": 3027 }, { "start_pos": 3078, "end_pos": 3080 }, { "start_pos": 514, "end_pos": 516 }, { "start_pos": 761, "end_pos": 763 }, { "start_pos": 815, "end_pos": 817 }, { "start_pos": 938, "end_pos": 940 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHE6-1", "uniprot_ac": "A0AAA9SHE6", "uniprot_id": "A0AAA9SHE6_BOVIN", "mass": { "chemical_mass": 85049.0, "monoisotopic_mass": 85049.0 }, "refseq": { "ac": "XP_024845660", "name": "kin of IRRE-like protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845660" }, "gene_names": [ { "name": "KIRREL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SHE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ] }, { "name": "KIRREL1", "type": "synonym", "evidence": [ { "id": "XP_024845660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845660" } ] } ], "protein_names": [ { "name": "Kin of IRRE-like protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SHE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#names_and_taxonomy" } ] }, { "name": "Kin of irregular chiasm-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SHE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#names_and_taxonomy" } ] }, { "name": "Nephrin-like protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SHE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#names_and_taxonomy" } ] }, { "name": "kin of IRRE-like protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845660" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIRREL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6", "locus": { "chromosome": "3", "start_pos": 12271292, "end_pos": 12372125, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005799", "url": "https://www.ensembl.org/id/ENSBTAG00000005799" } ] } } ], "crossref": [ { "id": "A0AAA9SHE6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHE6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005799", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05759", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05759", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05898", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05898", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781667", "url": "https://www.ncbi.nlm.nih.gov/gene/781667", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781667", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781667", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DTGQFNL", "url": "https://omabrowser.org/oma/group/DTGQFNL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3G9", "url": "https://www.orthodb.org/?gene=F1N3G9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11640:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11640:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024845660", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845660", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3G9", "url": "https://www.uniprot.org/uniprotkb/F1N3G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3G9-1", "url": "https://www.uniprot.org/uniprotkb/F1N3G9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSAEAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGIPHNLTCRAFNAKPAATILWFRDGTQQEGAVASTELLKDGKRETTISQLLINPTDLDIGRVFTCRSVNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRAPAPDYGPEPTPPGPAAPAGNDTASQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 773, "header": "tr|A0AAA9SHE6-1|A0AAA9SHE6_BOVIN Isoform 1 of Kin of IRRE-like protein 1 OS=Bos taurus OX=9913 GN=KIRREL1 PE=3 SV=1 CANONICAL=A0AAA9SHE6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#A0AAA9SHE6-1", "sequence": { "sequence": "MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSAEAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGIPHNLTCRAFNAKPAATILWFRDGTQQEGAVASTELLKDGKRETTISQLLINPTDLDIGRVFTCRSVNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRAPAPDYGPEPTPPGPAAPAGNDTASQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 773, "header": "tr|A0AAA9SHE6-1|A0AAA9SHE6_BOVIN Isoform 1 of Kin of IRRE-like protein 1 OS=Bos taurus OX=9913 GN=KIRREL1 PE=3 SV=1 CANONICAL=A0AAA9SHE6-1" }, "locus": { "chromosome": "3", "start_pos": 12371926, "end_pos": 12272296, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113629.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113629.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083140.1" } ] } }, { "isoform_ac": "A0AAA9TP54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#A0AAA9TP54-1", "sequence": { "sequence": "MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSAEAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRAPAPDYGPEPTPPGPAAPAGNDTASQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 654, "header": "tr|A0AAA9TP54-1|A0AAA9TP54_BOVIN Computationally mapped isoform of Kin of IRRE-like protein 1 OS=Bos taurus OX=9913 GN=KIRREL1 PE=3 SV=1 CANONICAL=A0AAA9SHE6-1" }, "locus": { "chromosome": "3", "start_pos": 12371926, "end_pos": 12272296, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124277.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124277.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099035.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099035.1" } ] } }, { "isoform_ac": "A0AAA9TUZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#A0AAA9TUZ5-1", "sequence": { "sequence": "MLSLLVWILTLSDTFSQVPPEDTRIDGGPVILLQAGIPHNLTCRAFNAKPAATILWFRDGTQQEGAVASTELLKDGKRETTISQLLINPTDLDIGRVFTCRSVNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRAPAPDYGPEPTPPGPAAPAGNDTASQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 657, "header": "tr|A0AAA9TUZ5-1|A0AAA9TUZ5_BOVIN Computationally mapped isoform of Kirre like nephrin family adhesion molecule 1 OS=Bos taurus OX=9913 GN=KIRREL1 PE=3 SV=2 CANONICAL=A0AAA9SHE6-1" }, "locus": { "chromosome": "3", "start_pos": 12371926, "end_pos": 12272296, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112708.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112708.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102441.2", "url": "https://www.ensembl.org/id/ENSBTAP00000102441.2" } ] } }, { "isoform_ac": "F1N3G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6/entry#F1N3G9-1", "sequence": { "sequence": "MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKVPPEDTRIDGGPVILLQAGIPHNLTCRAFNAKPAATILWFRDGTQQEGAVASTELLKDGKRETTISQLLINPTDLDIGRVFTCRSVNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRAPAPDYGPEPTPPGPAAPAGNDTASQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ", "length": 707, "header": "tr|F1N3G9-1|F1N3G9_BOVIN Computationally mapped isoform of Kirre like nephrin family adhesion molecule 1 OS=Bos taurus OX=9913 GN=KIRREL1 PE=3 SV=4 CANONICAL=A0AAA9SHE6-1" }, "locus": { "chromosome": "3", "start_pos": 12371926, "end_pos": 12272344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007626.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007626.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007626.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007626.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 682, "start_aa": "Thr", "end_pos": 682, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr682", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:781667", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781667", "resource": "KEGG Pathway" }, { "id": "R-BTA-373753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373753", "resource": "Reactome", "description": "Nephrin family interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480EKD7-1", "protein_name": "Kin of IRRE-like protein 1", "gene_name": "KIRREL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTKIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTISQLLINPTDLDIGRVFTCRSVNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFVIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVDVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRAPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 773 }, "evidence": [ { "id": "A0AAA9SHE6", "url": "https://omabrowser.org/oma/group/A0AAA9SHE6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6X936-1", "protein_name": "Kin of IRRE-like protein 1", "gene_name": "Kirrel1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLENRSTCLMTCQSSLLPKKPRFLSQKMWAPHLVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGHRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLLIQPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTTSISTATRVMKAIYSSFKDDVDLKQDLHCDTIETREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQLNTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 789 }, "evidence": [ { "id": "A0AAA9SHE6", "url": "https://omabrowser.org/oma/group/A0AAA9SHE6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80W68-1", "protein_name": "Kin of IRRE-like protein 1", "gene_name": "Kirrel1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLESPSTRLMTCQSSLLPEKPRFLSQKMWAPHLVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILVVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASISTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQLNTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 789 }, "evidence": [ { "id": "A0AAA9SHE6", "url": "https://omabrowser.org/oma/group/A0AAA9SHE6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96J84-1", "protein_name": "Kin of IRRE-like protein 1", "gene_name": "KIRREL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV", "length": 757 }, "evidence": [ { "id": "A0AAA9SHE6", "url": "https://omabrowser.org/oma/group/A0AAA9SHE6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "myosin binding", "id": "GO:0017022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "glomerular filtration", "id": "GO:0003094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" }, { "name": "cell-cell junction maintenance", "id": "GO:0045217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045217", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 115, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 682 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 487, "end_pos": 489 }, { "start_pos": 692, "end_pos": 694 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHE7-1", "uniprot_ac": "A0AAA9SHE7", "uniprot_id": "A0AAA9SHE7_BOVIN", "mass": { "chemical_mass": 22687.0, "monoisotopic_mass": 22687.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101907835", "type": "recommended", "evidence": [ { "id": "A0AAA9SHE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7" } ] } ], "protein_names": [ { "name": "THO complex subunit 7 homolog", "type": "recommended", "evidence": [ { "id": "A0AAA9SHE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7#function" }, { "database": "UniProtKB", "id": "ARBA00046174", "url": "https://www.uniprot.org/uniprotkb/ARBA00046174#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101907835", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SHE7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23405:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23405:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGARLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 195, "header": "tr|A0AAA9SHE7-1|A0AAA9SHE7_BOVIN Isoform 1 of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=LOC101907835 PE=3 SV=1 CANONICAL=A0AAA9SHE7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7/entry#A0AAA9SHE7-1", "sequence": { "sequence": "MGARLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 195, "header": "tr|A0AAA9SHE7-1|A0AAA9SHE7_BOVIN Isoform 1 of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=LOC101907835 PE=3 SV=1 CANONICAL=A0AAA9SHE7-1" }, "locus": { "chromosome": "17", "start_pos": 18425159, "end_pos": 18424479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012008.5", "url": "https://www.ensembl.org/id/ENSBTAT00000012008.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084764.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084764.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "THO complex part of transcription export complex", "id": "GO:0000445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000445", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHG6-1", "uniprot_ac": "A0AAA9SHG6", "uniprot_id": "A0AAA9SHG6_BOVIN", "mass": { "chemical_mass": 35495.0, "monoisotopic_mass": 35495.0 }, "refseq": { "ac": "NP_001376879", "name": "olfactory receptor family 2 subfamily A member 65", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376879" }, "gene_names": [ { "name": "OR2A65", "type": "recommended", "evidence": [ { "id": "A0AAA9SHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6" } ] }, { "name": "OR2A65", "type": "synonym", "evidence": [ { "id": "NP_001376879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376879" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2A2", "type": "synonym", "evidence": [ { "id": "NP_001376879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376879" } ] }, { "name": "olfactory receptor family 2 subfamily A member 65", "type": "synonym", "evidence": [ { "id": "NP_001376879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376879" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376879" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2A65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6", "locus": { "chromosome": "4", "start_pos": 107479981, "end_pos": 107479049, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059185", "url": "https://www.ensembl.org/id/ENSBTAG00000059185" } ] } } ], "crossref": [ { "id": "A0AAA9SHG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15420", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15420", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514662", "url": "https://www.ncbi.nlm.nih.gov/gene/514662", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514662", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514662", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376879", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGNQSWIAEFILIGFQLSEDMELVLFGIFSLLYTFNLLANGMILGLICLDPRLHTPMYYFLSHLAIIDISYASSNLPNLLANLVKHKKDISFVLCTLQMIFNLIFSSMECLILVVMSYDRFVAICHPLQYTVIMNWRVCMFLAIACWSCGLCLAIVQVSLFLRLPFCGPQKVNHFFCEIQSVLKVTCGDIWINEMFLFAEGVFILVGPLALMLVSYVHILWAILKIQSKEGRKKAFSTCSSHLCVVGFYFGIAMMVYLAPESSHREEQKKILFLFYCLFNPLLNPLVYSVRNAQVKAAFHRVLQKKRTV", "length": 310, "header": "tr|A0AAA9SHG6-1|A0AAA9SHG6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A65 PE=3 SV=1 CANONICAL=A0AAA9SHG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6/entry#A0AAA9SHG6-1", "sequence": { "sequence": "MEGNQSWIAEFILIGFQLSEDMELVLFGIFSLLYTFNLLANGMILGLICLDPRLHTPMYYFLSHLAIIDISYASSNLPNLLANLVKHKKDISFVLCTLQMIFNLIFSSMECLILVVMSYDRFVAICHPLQYTVIMNWRVCMFLAIACWSCGLCLAIVQVSLFLRLPFCGPQKVNHFFCEIQSVLKVTCGDIWINEMFLFAEGVFILVGPLALMLVSYVHILWAILKIQSKEGRKKAFSTCSSHLCVVGFYFGIAMMVYLAPESSHREEQKKILFLFYCLFNPLLNPLVYSVRNAQVKAAFHRVLQKKRTV", "length": 310, "header": "tr|A0AAA9SHG6-1|A0AAA9SHG6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A65 PE=3 SV=1 CANONICAL=A0AAA9SHG6-1" }, "locus": { "chromosome": "4", "start_pos": 107479978, "end_pos": 107479049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107393.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107393.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083165.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514662", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514662", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHH5-1", "uniprot_ac": "A0AAA9SHH5", "uniprot_id": "A0AAA9SHH5_BOVIN", "mass": { "chemical_mass": 21077.0, "monoisotopic_mass": 21077.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Canopy FGF signaling regulator 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SHH5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13341", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13341", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13341:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13341:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARSLRPVALLALLALLAGLPAARDPREPDVFCGACRALMDEVEHDVTKARQEKTKVGSFRINPDGTQERRKIPLAQSEAFLTDLLDKVCERMNDYRLEEDPVTKEKTFKRFAPRKGDKIYKEFKKFYFYSDAYRPLKFACETIIEEFEDEILSLITQEAHQLADTLCGEKSGLCETPTNHTEL", "length": 184, "header": "tr|A0AAA9SHH5-1|A0AAA9SHH5_BOVIN Isoform 1 of Canopy FGF signaling regulator 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SHH5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5/entry#A0AAA9SHH5-1", "sequence": { "sequence": "MARSLRPVALLALLALLAGLPAARDPREPDVFCGACRALMDEVEHDVTKARQEKTKVGSFRINPDGTQERRKIPLAQSEAFLTDLLDKVCERMNDYRLEEDPVTKEKTFKRFAPRKGDKIYKEFKKFYFYSDAYRPLKFACETIIEEFEDEILSLITQEAHQLADTLCGEKSGLCETPTNHTEL", "length": 184, "header": "tr|A0AAA9SHH5-1|A0AAA9SHH5_BOVIN Isoform 1 of Canopy FGF signaling regulator 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SHH5-1" }, "locus": { "chromosome": "4", "start_pos": 117317108, "end_pos": 117261923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095324.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095324.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085652.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085652.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHH5" }, { "id": "PS50015", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50015" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Saposin B-type", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 179, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHI3-1", "uniprot_ac": "A0AAA9SHI3", "uniprot_id": "A0AAA9SHI3_BOVIN", "mass": { "chemical_mass": 22036.0, "monoisotopic_mass": 22036.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SHI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SHI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNPLWTLLFVLSAPRGVLSQVQLRESGPSLVKPSQTLSLTCTVSGFSLSDNSVGWVRQAPGKALEWLGVIYSGGSTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCARDTVRGSQCEPRQKPPCTGARDHEGALRTQYRAESWSRELSKTLAADTAKSLQLCPTLCDPIDASPLGPTVPGILQARTLEWVAISFSNA", "length": 205, "header": "tr|A0AAA9SHI3-1|A0AAA9SHI3_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SHI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3/entry#A0AAA9SHI3-1", "sequence": { "sequence": "MNPLWTLLFVLSAPRGVLSQVQLRESGPSLVKPSQTLSLTCTVSGFSLSDNSVGWVRQAPGKALEWLGVIYSGGSTGYNPALKSRLSITKDNSKSQVSLSLSSVTTEDTATYYCARDTVRGSQCEPRQKPPCTGARDHEGALRTQYRAESWSRELSKTLAADTAKSLQLCPTLCDPIDASPLGPTVPGILQARTLEWVAISFSNA", "length": 205, "header": "tr|A0AAA9SHI3-1|A0AAA9SHI3_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SHI3-1" }, "locus": { "chromosome": "21", "start_pos": 292608, "end_pos": 291650, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100530.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100530.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083373.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083373.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 185, "start_aa": "Thr", "end_pos": 185, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr185", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3" } ], "pmid": "" }, { "name": "immunoglobulin complex", "id": "GO:0019814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI3" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 114, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 185 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHN2-1", "uniprot_ac": "A0AAA9SHN2", "uniprot_id": "A0AAA9SHN2_BOVIN", "mass": { "chemical_mass": 35858.0, "monoisotopic_mass": 35858.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "15-oxoprostaglandin 13-reductase", "type": "recommended", "evidence": [ { "id": "A0AAA9SHN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2/entry#names_and_taxonomy" } ] }, { "name": "1.3.1.48", "type": "synonym", "evidence": [ { "id": "A0AAA9SHN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SHN2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHN2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43205:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43205:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00107", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00107", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TSRCSSWVYKRESCQHPLDHQKKEVNLPDCVNERQVQVRTLYLSMDPYMRCRMNEDTGKNTNFTKGDFVTSFYWPWQTTVILDGNILEKVDPQLVDGHLSYFLEAIGMPGLTYLIGVQEKSHITAGSNQTMVVSGAAGACGSLAGQIGRLLGCSKVVGICGTPEKCLFLTSELGFNAAINYKEGNVAEQLHKLCPAGVDVYLNNVGGDISDTVISQMNQNSHIILCGQISQYNKDVPYPPLHPAIEAIQKERNITRERFLVLNYKDKFEFGILQLSQWFKEGKLKIKETRINGLENMGAAFQSMMTGGNIGKQIVCISGDTSL", "length": 323, "header": "tr|A0AAA9SHN2-1|A0AAA9SHN2_BOVIN Isoform 1 of 15-oxoprostaglandin 13-reductase OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SHN2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2/entry#A0AAA9SHN2-1", "sequence": { "sequence": "TSRCSSWVYKRESCQHPLDHQKKEVNLPDCVNERQVQVRTLYLSMDPYMRCRMNEDTGKNTNFTKGDFVTSFYWPWQTTVILDGNILEKVDPQLVDGHLSYFLEAIGMPGLTYLIGVQEKSHITAGSNQTMVVSGAAGACGSLAGQIGRLLGCSKVVGICGTPEKCLFLTSELGFNAAINYKEGNVAEQLHKLCPAGVDVYLNNVGGDISDTVISQMNQNSHIILCGQISQYNKDVPYPPLHPAIEAIQKERNITRERFLVLNYKDKFEFGILQLSQWFKEGKLKIKETRINGLENMGAAFQSMMTGGNIGKQIVCISGDTSL", "length": 323, "header": "tr|A0AAA9SHN2-1|A0AAA9SHN2_BOVIN Isoform 1 of 15-oxoprostaglandin 13-reductase OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SHN2-1" }, "locus": { "chromosome": "5", "start_pos": 17121667, "end_pos": 17119781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027699.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027699.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085714.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085714.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "id": "GO:0016628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN2" }, { "id": "PF00107", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00107" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alcohol dehydrogenase-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 239, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.3.1.48", "ec_name": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+).", "evidence": [ { "id": "1.3.1.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48" }, { "id": "1.3.1.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.1.48" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHN8-1", "uniprot_ac": "A0AAA9SHN8", "uniprot_id": "A0AAA9SHN8_BOVIN", "mass": { "chemical_mass": 94334.0, "monoisotopic_mass": 94334.0 }, "refseq": {}, "gene_names": [ { "name": "BRSK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ] } ], "protein_names": [ { "name": "BR serine/threonine kinase 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SHN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRSK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8", "locus": { "chromosome": "29", "start_pos": 50051859, "end_pos": 50101241, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059118", "url": "https://www.ensembl.org/id/ENSBTAG00000059118" } ] } } ], "crossref": [ { "id": "A0AAA9SHN8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14081", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14081", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346:SF108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346:SF108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21115", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21115", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21122", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21122", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "12801", "url": "https://www.rhea-db.org/rhea/12801", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53904", "url": "https://www.rhea-db.org/rhea/53904", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPVPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRALEMAQHGQRSRSISGASSGLSTSPLSSPRPIRKFVLPPPPPELPFVACPSATSAEPEACRSASRPGHLLPPQAAPRPNPKTQTLPSKAKLTDKPLQGTKSNPLPAGTQAQPLVPGGLSPEPALPPGPPTLPSPARLPTPGTEPNTKSVPTIQVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGAAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHEQPSAQHLSDTTNCMEMMTGRLSKCGSPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPAGKDKARTGLPAARREQP", "length": 860, "header": "tr|A0AAA9SHN8-1|A0AAA9SHN8_BOVIN Isoform 1 of BR serine/threonine kinase 2 OS=Bos taurus OX=9913 GN=BRSK2 PE=3 SV=1 CANONICAL=A0AAA9SHN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8/entry#A0AAA9SHN8-1", "sequence": { "sequence": "MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPVPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRALEMAQHGQRSRSISGASSGLSTSPLSSPRPIRKFVLPPPPPELPFVACPSATSAEPEACRSASRPGHLLPPQAAPRPNPKTQTLPSKAKLTDKPLQGTKSNPLPAGTQAQPLVPGGLSPEPALPPGPPTLPSPARLPTPGTEPNTKSVPTIQVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGAAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHEQPSAQHLSDTTNCMEMMTGRLSKCGSPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPAGKDKARTGLPAARREQP", "length": 860, "header": "tr|A0AAA9SHN8-1|A0AAA9SHN8_BOVIN Isoform 1 of BR serine/threonine kinase 2 OS=Bos taurus OX=9913 GN=BRSK2 PE=3 SV=1 CANONICAL=A0AAA9SHN8-1" }, "locus": { "chromosome": "29", "start_pos": 50100941, "end_pos": 50052863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133253.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133253.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085719.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085719.1" } ] } }, { "isoform_ac": "A0AAA9SKG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8/entry#A0AAA9SKG8-1", "sequence": { "sequence": "MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPVPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRALEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLSTSPLSSPRPIRKFVLPPPPPELPFVACPSATSAEPEACRSASRPGHLLPPQAAPRPNPKTQTLPSKAKLTDKPLQGTKSNPLPAGTQAQPLVPGGLSPEPALPPGPPTLPSPARLPTPGTEPNTKSVPTIQVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGAAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHEQPSAQHLSEPPPPAPGLSWGAGLKGQKVATSYESSL", "length": 820, "header": "tr|A0AAA9SKG8-1|A0AAA9SKG8_BOVIN Computationally mapped isoform of BR serine/threonine kinase 2 OS=Bos taurus OX=9913 GN=BRSK2 PE=3 SV=1 CANONICAL=A0AAA9SHN8-1" }, "locus": { "chromosome": "29", "start_pos": 50100941, "end_pos": 50056214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084373.1" } ] } }, { "isoform_ac": "A0AAA9SNP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8/entry#A0AAA9SNP5-1", "sequence": { "sequence": "MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPVPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRALEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGAAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHEQPSAQHLSDTTNCMEMMTGRLSKCDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPAGKDKARTGLPAARREQP", "length": 743, "header": "tr|A0AAA9SNP5-1|A0AAA9SNP5_BOVIN Computationally mapped isoform of BR serine/threonine kinase 2 OS=Bos taurus OX=9913 GN=BRSK2 PE=3 SV=1 CANONICAL=A0AAA9SHN8-1" }, "locus": { "chromosome": "29", "start_pos": 50100941, "end_pos": 50052863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119824.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119824.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085575.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 539, "start_aa": "Thr", "end_pos": 539, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr539", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 587, "start_aa": "Thr", "end_pos": 587, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr587", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "regulation of axonogenesis", "id": "GO:0050770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "G2/M transition of mitotic cell cycle", "id": "GO:0000086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "regulation of insulin secretion involved in cellular response to glucose stimulus", "id": "GO:0061178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "id": "GO:0070059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "establishment of cell polarity", "id": "GO:0030010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization involved in establishment of planar polarity", "id": "GO:0090176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "tau-protein kinase activity", "id": "GO:0050321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12801", "name": "", "equation": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LJI4-1", "A0A3Q1NDU7-1", "P35508-1", "A0ABI0NQQ4-1", "G5E5D4-1", "A0AAA9T8T9-1" ], "evidence": [ { "id": "12801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12801" } ] }, { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "53904", "name": "", "equation": "L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LJI4-1", "A0A3Q1NDU7-1", "P35508-1", "A0ABI0NQQ4-1", "G5E5D4-1", "A0AAA9T8T9-1" ], "evidence": [ { "id": "53904", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53904" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJI4", "gene_name": "GSK3A", "activity": [ { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJI4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0A3Q1LJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJI4" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NDU7", "gene_name": "GSK3B", "activity": [ { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN8" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 271, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 539, 587 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 631, "end_pos": 633 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHP1-1", "uniprot_ac": "A0AAA9SHP1", "uniprot_id": "A0AAA9SHP1_BOVIN", "mass": { "chemical_mass": 68174.0, "monoisotopic_mass": 68174.0 }, "refseq": { "ac": "XP_015327901", "name": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327901" }, "gene_names": [ { "name": "LINGO2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1" } ] }, { "name": "LINGO2", "type": "synonym", "evidence": [ { "id": "XP_015327901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327901" } ] } ], "protein_names": [ { "name": "Leucine rich repeat and Ig domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2", "type": "synonym", "evidence": [ { "id": "XP_015327901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327901" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LINGO2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1", "locus": { "chromosome": "8", "start_pos": 16310519, "end_pos": 15612507, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064575", "url": "https://www.ensembl.org/id/ENSBTAG00000064575" } ] } } ], "crossref": [ { "id": "539968", "url": "https://www.ncbi.nlm.nih.gov/gene/539968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539968", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539968", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TKAVVCH", "url": "https://omabrowser.org/oma/group/TKAVVCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015327901", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327901", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHTALSCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTIPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLTCDCRLLWILQRHPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI", "length": 606, "header": "tr|A0AAA9SHP1-1|A0AAA9SHP1_BOVIN Isoform 1 of Leucine rich repeat and Ig domain containing 2 OS=Bos taurus OX=9913 GN=LINGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1/entry#A0AAA9SHP1-1", "sequence": { "sequence": "MLHTALSCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTIPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLTCDCRLLWILQRHPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI", "length": 606, "header": "tr|A0AAA9SHP1-1|A0AAA9SHP1_BOVIN Isoform 1 of Leucine rich repeat and Ig domain containing 2 OS=Bos taurus OX=9913 GN=LINGO2 PE=4 SV=1 CANONICAL=A0AAA9SHP1-1" }, "locus": { "chromosome": "8", "start_pos": 16300849, "end_pos": 16299032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111325.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111325.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075837.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539968", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539968", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XM05-1", "protein_name": "Leucine rich repeat and Ig domain containing 2", "gene_name": "", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLHTAVSCWQPFLGLAVLLVFMGPTFGCPARCECSAQNKSVSCHRRRLLSIPEGIPIETKILDLSKNRLKSVNPEEFMSYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLERCNLTAVPTEALSHLHNLISLHLKQLNINALPAYAFKRLFRLKDLEIDSWPLLDMLPANSLYGLNLTSLSITNTNLSAVPYTAFKHLVYLTHLNLSFNPISTIEAGMLSDLVRLQELHMVGAQLRTIEPHAFQGLRFLRVLNVSQNLLETLEENVFHSPKALEILCINNNPLACDCRLLWILQRQPTLQFGGQPPMCAGPDSVKERSFKDFHSTALSFYFTCKKPRIQDKKLQYLVVEEGQTVQLMCNADGDPQPTISWVTPRRRLITTKSNGRATVLGDGTLEIRFAQDQDTGIYVCIASNAAGNDTYSASLTVKGFTSDRFLYANRTPMYMTDSNDTSSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKTSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI", "length": 606 }, "evidence": [ { "id": "A0AAA9SHP1", "url": "https://omabrowser.org/oma/group/A0AAA9SHP1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4FBD2-1", "protein_name": "Leucine rich repeat and Ig domain containing 2", "gene_name": "LINGO2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRHPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGIYVCIASNAAGNDTFTASLTVKGFTSDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVAEGEVAGPRRFNMKMI", "length": 606 }, "evidence": [ { "id": "A0AAA9SHP1", "url": "https://omabrowser.org/oma/group/A0AAA9SHP1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R752-1", "protein_name": "Leucine rich repeat and Ig domain containing 2", "gene_name": "Lingo2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLHTAIPCWQPFLGLAMVLLFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLFSLEQLTLEKCNLTAVPTEALSHLRSLITLHLKHLNINNMPVYAFKRLFHLKQLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHVVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQATLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVAEGEVAGPRRFNMKMI", "length": 606 }, "evidence": [ { "id": "A0AAA9SHP1", "url": "https://omabrowser.org/oma/group/A0AAA9SHP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3URE9-1", "protein_name": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2", "gene_name": "Lingo2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLHTAIPCWQPFLGLAVVLLLMGSTIGCPARCECSAQNKSVSCHRRRLLAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQPNLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI", "length": 606 }, "evidence": [ { "id": "A0AAA9SHP1", "url": "https://omabrowser.org/oma/group/A0AAA9SHP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7L985-1", "protein_name": "Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2", "gene_name": "LINGO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI", "length": 606 }, "evidence": [ { "id": "A0AAA9SHP1", "url": "https://omabrowser.org/oma/group/A0AAA9SHP1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 491, "end_pos": 493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 527, "end_pos": 529, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 410, "end_pos": 499, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 279, "end_pos": 281 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 38, "end_pos": 40 }, { "start_pos": 491, "end_pos": 493 }, { "start_pos": 512, "end_pos": 514 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 527, "end_pos": 529 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHR9-1", "uniprot_ac": "A0AAA9SHR9", "uniprot_id": "A0AAA9SHR9_BOVIN", "mass": { "chemical_mass": 37159.0, "monoisotopic_mass": 37159.0 }, "refseq": {}, "gene_names": [ { "name": "B3GAT2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ] } ], "protein_names": [ { "name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.135", "type": "synonym", "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "B3GAT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9", "locus": { "chromosome": "9", "start_pos": 10022958, "end_pos": 10070245, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020817", "url": "https://www.ensembl.org/id/ENSBTAG00000020817" } ] } } ], "crossref": [ { "id": "A0AAA9SHR9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00218", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00218", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10896", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10896", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10896:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10896:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03360", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03360", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "24168", "url": "https://www.rhea-db.org/rhea/24168", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SHR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSVLFSRFFMLLPWILIVIIMLDVDTRRPTPPLTPRPYFAPYSGGRGGARLPLRRGGPGRGREPRNESWPRPPPPPPEPPLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAAARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHGHQRAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLRQITTVEELEPKANNCTKVLVWHTRTEKVNLANEPKYHLDTVTIEV", "length": 326, "header": "tr|A0AAA9SHR9-1|A0AAA9SHR9_BOVIN Isoform 1 of Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase OS=Bos taurus OX=9913 GN=B3GAT2 PE=3 SV=2 CANONICAL=A0AAA9SHR9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9/entry#A0AAA9SHR9-1", "sequence": { "sequence": "MKSVLFSRFFMLLPWILIVIIMLDVDTRRPTPPLTPRPYFAPYSGGRGGARLPLRRGGPGRGREPRNESWPRPPPPPPEPPLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAAARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHGHQRAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLRQITTVEELEPKANNCTKVLVWHTRTEKVNLANEPKYHLDTVTIEV", "length": 326, "header": "tr|A0AAA9SHR9-1|A0AAA9SHR9_BOVIN Isoform 1 of Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase OS=Bos taurus OX=9913 GN=B3GAT2 PE=3 SV=2 CANONICAL=A0AAA9SHR9-1" }, "locus": { "chromosome": "9", "start_pos": 10070046, "end_pos": 9975344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104467.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104467.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082058.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082058.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 295, "start_aa": "Asn", "end_pos": 295, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn295", "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9#ptm_processing" }, { "id": "PIRSR605027-6", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605027-6" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 89, "start_aa": "Thr", "end_pos": 89, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ], "pmid": "" }, { "name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "id": "GO:0015018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24168", "name": "", "equation": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LG25-1", "A0AAA9SHR9-1", "F1MQ60-1" ], "evidence": [ { "id": "24168", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24168" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG25", "gene_name": "B3GAT3", "activity": [ { "ec_number": "2.4.1.135", "activity": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "A0A3Q1LG25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG25" } ] }, { "ec_number": "2.4.1.135", "activity": "", "evidence": [ { "id": "A0A3Q1LG25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG25" } ] } ] }, { "uniprot_ac": "A0AAA9SHR9", "gene_name": "B3GAT2", "activity": [ { "ec_number": "2.4.1.135", "activity": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ] }, { "ec_number": "2.4.1.135", "activity": "", "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" } ] } ] }, { "uniprot_ac": "F1MQ60", "gene_name": "B3GAT1", "activity": [ { "ec_number": "2.4.1.135", "activity": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "F1MQ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ60" } ] }, { "ec_number": "2.4.1.135", "activity": "", "evidence": [ { "id": "F1MQ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ60" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9#function" }, { "id": "A0AAA9SHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR9" }, { "id": "PIRSR605027-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605027-3" } ], "binding_site_uniprot": 190, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29035", "ligand": "Mn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 190, "end_pos": 190, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [ { "glytoucan_ac": "G01954ZH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G06898ZN", "type": "O-linked", "subtype": "O-mannose core M1" }, { "glytoucan_ac": "G16475ZM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17406OI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18129IO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G18434DQ", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G25614IV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G30265AO", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G43848AQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G47519VR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53366RQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G55005SM", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G57941GW", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G60606QD", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G73224TY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G77291EZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G79253EJ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G82208GO", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G87632FZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G89932GS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G99103PU", "type": "O-linked", "subtype": "O-mannose core M1" } ], "enzyme_annotation": [ { "ec_number": "2.4.1.135", "ec_name": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "2.4.1.135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135" }, { "id": "2.4.1.135", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.135" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 295 ], "o_linked_sites": [ 89 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHS1-1", "uniprot_ac": "A0AAA9SHS1", "uniprot_id": "A0AAA9SHS1_BOVIN", "mass": { "chemical_mass": 12216.0, "monoisotopic_mass": 12216.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SHS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SHS1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQTVIQDQPDISSQLGQSVTLNCRYATTWSSYHYMFWYKLLPNGEMIYLIGHSGQNERHGRYSVNFQKARKSISLTISDLQLEDSAKYFCALWELTVLEVMGIAK", "length": 106, "header": "tr|A0AAA9SHS1-1|A0AAA9SHS1_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SHS1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1/entry#A0AAA9SHS1-1", "sequence": { "sequence": "MAQTVIQDQPDISSQLGQSVTLNCRYATTWSSYHYMFWYKLLPNGEMIYLIGHSGQNERHGRYSVNFQKARKSISLTISDLQLEDSAKYFCALWELTVLEVMGIAK", "length": 106, "header": "tr|A0AAA9SHS1-1|A0AAA9SHS1_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SHS1-1" }, "locus": { "chromosome": "10", "start_pos": 23235977, "end_pos": 23235660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134925.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134925.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084890.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084890.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHS1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 91, "start_aa": "Gln", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHT9-1", "uniprot_ac": "A0AAA9SHT9", "uniprot_id": "A0AAA9SHT9_BOVIN", "mass": { "chemical_mass": 137806.0, "monoisotopic_mass": 137806.0 }, "refseq": {}, "gene_names": [ { "name": "IRS2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ] } ], "protein_names": [ { "name": "Insulin receptor substrate 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IRS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9", "locus": { "chromosome": "12", "start_pos": 84627061, "end_pos": 84655278, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012019", "url": "https://www.ensembl.org/id/ENSBTAG00000012019" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01204", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01204", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100300012", "url": "https://www.ncbi.nlm.nih.gov/gene/100300012", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100300012", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300012", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10614:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10614:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-109704", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-112399", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112399", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-112412", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112412", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1257604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1266695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1266695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-198203", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198203", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2428928", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2428928", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-74713", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74713", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-74749", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74749", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9006335", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9006335", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9027276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9027276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9027284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9027284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJE0", "url": "https://www.uniprot.org/uniprotkb/F1MJE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJE0-1", "url": "https://www.uniprot.org/uniprotkb/F1MJE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEAGAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAAADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSACRVRTASEGDGGAAAAAAAGAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGGGLQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMERPLSHCGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVALLGTGSGSCKSDDYMPMSPTSVSAPKQILQPRPVPAALPPAGATVPTPASAAGRAFPGTAGSYKTGSPAESSPEDSGYMRMWCGSKLSMESADSKLLPNGDYLNMSPSDAGTAGTPPDFFSAAGETLRCVPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPPPGPAQPASAFPAAAAGSGHPQPLHPVVPSSGRPGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEYPLPPEPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSGDSRQRSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSALQPPPPPPPPGELYRLPAAPASQGPGAASSSSSDTGDNSDYTEMAFGVAATPPQPIAAPPKPDGARVSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHTPKRHNSASVENVCLRKGSEGGGAGGSVLGGGDEPPSSPRQLPPPTPQQARAWTPAQPGGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEPGLSPPLQQHPHAQMGDRSAWGRTRSLGGLISAVGAGSPAGVCGGPGPGALPAANAYASIDFLTHHLKEATVVKAPWTVARQAPLSMGFSR", "length": 1341, "header": "tr|A0AAA9SHT9-1|A0AAA9SHT9_BOVIN Isoform 1 of Insulin receptor substrate 2 OS=Bos taurus OX=9913 GN=IRS2 PE=4 SV=1 CANONICAL=A0AAA9SHT9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9/entry#A0AAA9SHT9-1", "sequence": { "sequence": "MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEAGAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAAADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSACRVRTASEGDGGAAAAAAAGAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGGGLQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMERPLSHCGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVALLGTGSGSCKSDDYMPMSPTSVSAPKQILQPRPVPAALPPAGATVPTPASAAGRAFPGTAGSYKTGSPAESSPEDSGYMRMWCGSKLSMESADSKLLPNGDYLNMSPSDAGTAGTPPDFFSAAGETLRCVPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPPPGPAQPASAFPAAAAGSGHPQPLHPVVPSSGRPGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEYPLPPEPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSGDSRQRSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSALQPPPPPPPPGELYRLPAAPASQGPGAASSSSSDTGDNSDYTEMAFGVAATPPQPIAAPPKPDGARVSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHTPKRHNSASVENVCLRKGSEGGGAGGSVLGGGDEPPSSPRQLPPPTPQQARAWTPAQPGGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEPGLSPPLQQHPHAQMGDRSAWGRTRSLGGLISAVGAGSPAGVCGGPGPGALPAANAYASIDFLTHHLKEATVVKAPWTVARQAPLSMGFSR", "length": 1341, "header": "tr|A0AAA9SHT9-1|A0AAA9SHT9_BOVIN Isoform 1 of Insulin receptor substrate 2 OS=Bos taurus OX=9913 GN=IRS2 PE=4 SV=1 CANONICAL=A0AAA9SHT9-1" }, "locus": { "chromosome": "12", "start_pos": 84655079, "end_pos": 84640935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085784.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085784.1" } ] } }, { "isoform_ac": "A0AAA9SZJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9/entry#A0AAA9SZJ6-1", "sequence": { "sequence": "MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEAGAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAAADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSACRVRTASEGDGGAAAAAAAGAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGGGLQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMERPLSHCGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVALLGTGSGSCKSDDYMPMSPTSVSAPKQILQPRPVPAALPPAGATVPTPASAAGRAFPGTAGSYKTGSPAESSPEDSGYMRMWCGSKLSMESADSKLLPNGDYLNMSPSDAGTAGTPPDFFSAAGETLRCVPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPPPGPAQPASAFPAAAAGSGHPQPLHPVVPSSGRPGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEYPLPPEPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSGDSRQRSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSALQPPPPPPPPGELYRLPAAPASQGPGAASSSSSDTGDNSDYTEMAFGVAATPPQPIAAPPKPDGARVSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHTPKRHNSASVENVCLRKGSEGGGAGGSVLGGGDEPPSSPRQLPPPTPQQARAWTPAQPGGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEPGLSPPLQQHPHAQMGDRSAWGRTRSLGGLISAVGAGSPAGVCGGPGPGALPAANAYASIDFLTHHLKEATVVKE", "length": 1325, "header": "tr|A0AAA9SZJ6-1|A0AAA9SZJ6_BOVIN Computationally mapped isoform of Insulin receptor substrate 2 OS=Bos taurus OX=9913 GN=IRS2 PE=4 SV=1 CANONICAL=A0AAA9SHT9-1" }, "locus": { "chromosome": "12", "start_pos": 84655079, "end_pos": 84627505, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114187.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114187.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088800.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088800.1" } ] } }, { "isoform_ac": "F1MJE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9/entry#F1MJE0-1", "sequence": { "sequence": "MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEAGAGGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAAADDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSACRVRTASEGDGGAAAAAAAGAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGGGLQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMERPLSHCGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSSGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVALLGTGSGSCKSDDYMPMSPTSVSAPKQILQPRPVPAALPPAGATVPTPASAAGRAFPGTAGSYKTGSPAESSPEDSGYMRMWCGSKLSMESADSKLLPNGDYLNMSPSDAGTAGTPPDFFSAAGETLRCVPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPPPGPAQPASAFPAAAAGSGHPQPLHPVVPSSGRPGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEYPLPPEPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSGDSRQRSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSALQPPPPPPPPGELYRLPAAPASQGPGAASSSSSDTGDNSDYTEMAFGVAATPPQPIAAPPKPDGARVSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHTPKRHNSASVENVCLRKGSEGGGAGGSVLGGGDEPPSSPRQLPPPTPQQARAWTPAQPGGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEPGLSPPLQQHPHAQMGDRSAWGRTRSLGGLISAVGAGSPAGVCGGPGPGALPAANAYASIDFLTHHLKEATVVKGLHAKWISSRPI", "length": 1336, "header": "tr|F1MJE0-1|A0AAA9SHT9_BOVIN Computationally mapped isoform of Insulin receptor substrate 2 OS=Bos taurus OX=9913 GN=IRS2 PE=4 SV=4 CANONICAL=A0AAA9SHT9-1" }, "locus": { "chromosome": "12", "start_pos": 84655079, "end_pos": 84648669, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015938.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015938.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049448.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049448.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1201, "start_aa": "Thr", "end_pos": 1201, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1201", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 702, "start_aa": "Thr", "end_pos": 702, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr702", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100300012", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300012", "resource": "KEGG Pathway" }, { "id": "R-BTA-109704", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "resource": "Reactome", "description": "PI3K Cascade" }, { "id": "R-BTA-112399", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112399", "resource": "Reactome", "description": "IRS-mediated signalling" }, { "id": "R-BTA-112412", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112412", "resource": "Reactome", "description": "SOS-mediated signalling" }, { "id": "R-BTA-1257604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-BTA-1266695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1266695", "resource": "Reactome", "description": "Interleukin-7 signaling" }, { "id": "R-BTA-198203", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198203", "resource": "Reactome", "description": "PI3K/AKT activation" }, { "id": "R-BTA-2428928", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2428928", "resource": "Reactome", "description": "IRS-related events triggered by IGF1R" }, { "id": "R-BTA-5673001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "resource": "Reactome", "description": "RAF/MAP kinase cascade" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-74713", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74713", "resource": "Reactome", "description": "IRS activation" }, { "id": "R-BTA-74749", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74749", "resource": "Reactome", "description": "Signal attenuation" }, { "id": "R-BTA-8853659", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "resource": "Reactome", "description": "RET signaling" }, { "id": "R-BTA-9006335", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9006335", "resource": "Reactome", "description": "Signaling by Erythropoietin" }, { "id": "R-BTA-9027276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9027276", "resource": "Reactome", "description": "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)" }, { "id": "R-BTA-9027284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9027284", "resource": "Reactome", "description": "Erythropoietin activates RAS" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase binding", "id": "GO:0043548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043548", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase adaptor activity", "id": "GO:0005068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005068", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase activator activity", "id": "GO:0141038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "positive regulation of fatty acid beta-oxidation", "id": "GO:0032000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "positive regulation of B cell proliferation", "id": "GO:0030890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030890", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "insulin receptor signaling pathway", "id": "GO:0008286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "response to glucose", "id": "GO:0009749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009749", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "negative regulation of long-chain fatty acid import across plasma membrane", "id": "GO:0010748", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010748", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "positive regulation of glycogen biosynthetic process", "id": "GO:0045725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "positive regulation of D-glucose import", "id": "GO:0046326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046326", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "insulin-like growth factor receptor signaling pathway", "id": "GO:0048009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048009", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "negative regulation of B cell apoptotic process", "id": "GO:0002903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002903", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" }, { "name": "positive regulation of transport", "id": "GO:0051050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 759, "end_pos": 761, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" }, { "id": "PS51064", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51064" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IRS-type PTB", "eco_id": "ECO_0000259", "start_pos": 195, "end_pos": 299, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SHT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT9" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 144, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 702, 1201 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 759, "end_pos": 761 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHV1-1", "uniprot_ac": "A0AAA9SHV1", "uniprot_id": "A0AAA9SHV1_BOVIN", "mass": { "chemical_mass": 48848.0, "monoisotopic_mass": 48848.0 }, "refseq": { "ac": "XP_010810567", "name": "sodium/bile acid cotransporter 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810567" }, "gene_names": [ { "name": "SLC10A5", "type": "recommended", "evidence": [ { "id": "A0AAA9SHV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1" } ] }, { "name": "SLC10A5", "type": "synonym", "evidence": [ { "id": "XP_010810567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810567" } ] } ], "protein_names": [ { "name": "Inositol monophosphatase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SHV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1/entry#names_and_taxonomy" } ] }, { "name": "sodium/bile acid cotransporter 5", "type": "synonym", "evidence": [ { "id": "XP_010810567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810567" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC10A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1", "locus": { "chromosome": "14", "start_pos": 80901137, "end_pos": 80887222, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060527", "url": "https://www.ensembl.org/id/ENSBTAG00000060527" } ] } } ], "crossref": [ { "id": "104968462", "url": "https://www.ncbi.nlm.nih.gov/gene/104968462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968462", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968462", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWMAHFR", "url": "https://omabrowser.org/oma/group/AWMAHFR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10361", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10361:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10361:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010810567", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIRKLFIILLLSSVTLGEARKSFLSFLNIEKTEVLFITKTEETVVVRSSYRDKQPNSSYLRVQLEDDKMLQVVNVTKTLSDVTNFTIHLVTGGDGETNLTVQLWDSEGRRERLIEEIKNVRVRVLRQRQDSPFQASNLINRNILMLFLPMILLNKCAFGCKIEFQVFETVWKRPLPVVLGAVIQFFLMPFCGFLLTQILALPEAQAFGFIVTCTCPGGGGGYLFALLLEGDVTLAILMTCTSTFLALVTMPTNSYIYSRILGLSGTLHIPISKIMSTLLFILAPMSVGIVIKHRLPDKAKFLERIIRPLSFILMFIGIYVTFSMGLVFLKTVNLGVLLLGVLVPALGLLFGYFFAKISMLPLPVCKTVAIEGGVLNSFLALAIIQLSFSQSDADLASVAPFTVAMCSGCEMLLILLFYKAKKRCILNIEEKRMKNPPV", "length": 438, "header": "tr|A0AAA9SHV1-1|A0AAA9SHV1_BOVIN Isoform 1 of Inositol monophosphatase 1 OS=Bos taurus OX=9913 GN=SLC10A5 PE=3 SV=1 CANONICAL=A0AAA9SHV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1/entry#A0AAA9SHV1-1", "sequence": { "sequence": "MIRKLFIILLLSSVTLGEARKSFLSFLNIEKTEVLFITKTEETVVVRSSYRDKQPNSSYLRVQLEDDKMLQVVNVTKTLSDVTNFTIHLVTGGDGETNLTVQLWDSEGRRERLIEEIKNVRVRVLRQRQDSPFQASNLINRNILMLFLPMILLNKCAFGCKIEFQVFETVWKRPLPVVLGAVIQFFLMPFCGFLLTQILALPEAQAFGFIVTCTCPGGGGGYLFALLLEGDVTLAILMTCTSTFLALVTMPTNSYIYSRILGLSGTLHIPISKIMSTLLFILAPMSVGIVIKHRLPDKAKFLERIIRPLSFILMFIGIYVTFSMGLVFLKTVNLGVLLLGVLVPALGLLFGYFFAKISMLPLPVCKTVAIEGGVLNSFLALAIIQLSFSQSDADLASVAPFTVAMCSGCEMLLILLFYKAKKRCILNIEEKRMKNPPV", "length": 438, "header": "tr|A0AAA9SHV1-1|A0AAA9SHV1_BOVIN Isoform 1 of Inositol monophosphatase 1 OS=Bos taurus OX=9913 GN=SLC10A5 PE=3 SV=1 CANONICAL=A0AAA9SHV1-1" }, "locus": { "chromosome": "14", "start_pos": 80892326, "end_pos": 80891013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137127.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137127.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107166.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104968462", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968462", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LSF0-1", "protein_name": "Sodium/bile acid cotransporter 5", "gene_name": "Slc10a5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFGNFFLILLLLVTPGEARKSFLSFLNIQNTEILSFAKTEETVVVRSSYKDKRPNSSYLFVKLEDPKVLQVVNVTKTLLDVTDFTISLMTSPGETNLTIQLWDSEGRQKILIEEIKNVKVKVLLQTKGSLFQAPMHVNRYILMLILSMVLLNKCAFGCKIEFQVLQTVWKKPLPVVLGTVTQFFLMPFCGFLLSQIFGLSKAQAFGFVLTCTCPGGGGGYLFALLLEGDITLAILMTCTSTTLALIMMPVNSYLYSRLLGLPGVFHVPVLKIVSTLLFILTPISIGVVIKHKTPQKAACLERVVRPLSLTLMFVGIYLAFRMGLVFLRMANLDMLLLGLLVPALGFLFGYSFAKVSMLPLPVCKTVAIESGMLNSFLALAIIQLSFSQSKAYEASVAPFTTAMCSGCEMLLLLLIYKGKKRGILSTGTEKTPLV", "length": 434 }, "evidence": [ { "id": "A0AAA9SHV1", "url": "https://omabrowser.org/oma/group/A0AAA9SHV1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5PT54-1", "protein_name": "Sodium/bile acid cotransporter 5", "gene_name": "Slc10a5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGNFFIFLLLLVTPGEAKKSFLSFLNIQNTEMLSFTRTEENIVVRSSYKDKQPHSSYLLVKLEDPKVLQVVNVTKTSLAVTDFTVNLKTFPGETNVTLQLWESEGRQTTLIDELKNVRVRVFRQTDDSLLQAPIHVDSSIFLLVLSMILLNKCAFGCKIEFQVLQTVWKRPLPILLGVVIQFFLMPFCGFLLSQILGLPKAQAFGFVMTCTCPGGGGGYLFALLLEGDVTLAILMTCTSTSLALIMMPVNSYFYSRLLGLAGAFHVPVLKIVSTLLFILMPMSTGVIIKHKMPAKAICLERVVRPLSLTLMFVGIYLAFRMGLVFLRMANLEVFLLGLLVPALGLLFGYSLAKVYLLPLPVCKTVALETGMLNSFLALAIIQLSFSQPKAHEASVAPFTVAMCSSCEMLLLLLVYKAKRRPSLSTEYEKTPLV", "length": 434 }, "evidence": [ { "id": "A0AAA9SHV1", "url": "https://omabrowser.org/oma/group/A0AAA9SHV1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5PT55-1", "protein_name": "Sodium/bile acid cotransporter 5", "gene_name": "SLC10A5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIRKLFIVLLLLLVTIEEARMSSLSFLNIEKTEILFFTKTEETILVSSSYENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINLVTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKDSLLQAPMHIDRNILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAFGVVMTCTCPGGGGGYLFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIYSRILGLSGTFHIPVSKIVSTLLFILVPVSIGIVIKHRIPEKASFLERIIRPLSFILMFVGIYLTFTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVCKTVAIESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIILVYKAKKRCIFFLQDKRKRNFLI", "length": 438 }, "evidence": [ { "id": "A0AAA9SHV1", "url": "https://omabrowser.org/oma/group/A0AAA9SHV1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VXV4-1", "protein_name": "P3 protein", "gene_name": "Dmel\\CG11655", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSPHGRPGWEWSYLLLTLAVGFASTHGWMAHFRPAALTLQMERGDRVQLKLENVAPSTLQQPTRYHFRLESVDTDLASVPGENATISLDVFNTDTRDWTGDIVVNGHFLGQTKIQVKLYDSQRNTSELPTNWSNDSTLDVKIKRPKRVVDDIFLGTIILLMSLLYISFGAALNLDVLRGLITRPTGPCIGFVMQVVGMPLLSYALGVFIFPQAPAMQLGLFFTGISPSGGASNTWSAVLGGNIHLSVLMTTVSNVAAFATIPLWTITLGQLIFERAGIKVPYGKIASYSSSLVLPLLLGLLVQKRMPQVARVLVRLLKPVSAFIILFIIVFAIINNFYLFYLFSWQIVVAGMALPGLGYIFAFLAAKLLHQNAADALTIAIETGIQNTGIAIFLLTTTLESPEADITTVVPVSVAVMTPLPLLGIYLYNRCWGNKRISEASATASEAERIAGAIH", "length": 455 }, "evidence": [ { "id": "A0AAA9SHV1", "url": "https://omabrowser.org/oma/group/A0AAA9SHV1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV1" }, { "id": "PF24690", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24690" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTCP5/P3 N-terminal", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 124, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 56, "end_pos": 58 }, { "start_pos": 74, "end_pos": 76 }, { "start_pos": 84, "end_pos": 86 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHX0-1", "uniprot_ac": "A0AAA9SHX0", "uniprot_id": "A0AAA9SHX0_BOVIN", "mass": { "chemical_mass": 14869.0, "monoisotopic_mass": 14869.0 }, "refseq": {}, "gene_names": [ { "name": "TAFA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SHX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ] } ], "protein_names": [ { "name": "TAFA chemokine like family member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SHX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAFA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0", "locus": { "chromosome": "22", "start_pos": 32965288, "end_pos": 33471946, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019041", "url": "https://www.ensembl.org/id/ENSBTAG00000019041" } ] } } ], "crossref": [ { "id": "A0AAA9SHX0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019041", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019041", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR020350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CQGSLQQ", "url": "https://omabrowser.org/oma/group/CQGSLQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31770", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31770", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31770:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31770:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ13", "url": "https://www.uniprot.org/uniprotkb/F1MJ13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ13-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMVSAMSWVLYLWISACAVLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 133, "header": "tr|A0AAA9SHX0-1|A0AAA9SHX0_BOVIN Isoform 1 of TAFA chemokine like family member 1 OS=Bos taurus OX=9913 GN=TAFA1 PE=3 SV=1 CANONICAL=A0AAA9SHX0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0/entry#A0AAA9SHX0-1", "sequence": { "sequence": "MAMVSAMSWVLYLWISACAVLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 133, "header": "tr|A0AAA9SHX0-1|A0AAA9SHX0_BOVIN Isoform 1 of TAFA chemokine like family member 1 OS=Bos taurus OX=9913 GN=TAFA1 PE=3 SV=1 CANONICAL=A0AAA9SHX0-1" }, "locus": { "chromosome": "22", "start_pos": 33471943, "end_pos": 32966392, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114365.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114365.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085822.1" } ] } }, { "isoform_ac": "F1MJ13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0/entry#F1MJ13-1", "sequence": { "sequence": "MAMVSAMSWVLYLWISACAVLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRVSCFLFLEMSHACYRLYCLPLCCIKNTQRSFEQERKKPFPQQKLFLTVQISVHPSKRS", "length": 186, "header": "tr|F1MJ13-1|F1MJ13_BOVIN Computationally mapped isoform of TAFA chemokine like family member 1 OS=Bos taurus OX=9913 GN=TAFA1 PE=3 SV=4 CANONICAL=A0AAA9SHX0-1" }, "locus": { "chromosome": "22", "start_pos": 33471943, "end_pos": 32971887, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025342.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025342.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025342.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025342.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MCT3-1", "protein_name": "Chemokine-like protein TAFA-1", "gene_name": "Tafa1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAMVSAMSWVLYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 133 }, "evidence": [ { "id": "A0AAA9SHX0", "url": "https://omabrowser.org/oma/group/A0AAA9SHX0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I5ZYE4-1", "protein_name": "TAFA chemokine like family member 1", "gene_name": "Tafa1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTMVSAMSWVLYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 133 }, "evidence": [ { "id": "A0AAA9SHX0", "url": "https://omabrowser.org/oma/group/A0AAA9SHX0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Z523-1", "protein_name": "TAFA chemokine like family member 1", "gene_name": "FAM19A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVVSAMSWVLYLWISACAMLLCQGSLHHTFQQHHLHRPGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 132 }, "evidence": [ { "id": "A0AAA9SHX0", "url": "https://omabrowser.org/oma/group/A0AAA9SHX0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7TPG8-1", "protein_name": "Chemokine-like protein TAFA-1", "gene_name": "Tafa1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMVSAMSWALYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 133 }, "evidence": [ { "id": "A0AAA9SHX0", "url": "https://omabrowser.org/oma/group/A0AAA9SHX0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z5A9-1", "protein_name": "Chemokine-like protein TAFA-1", "gene_name": "TAFA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMVSAMSWVLYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT", "length": 133 }, "evidence": [ { "id": "A0AAA9SHX0", "url": "https://omabrowser.org/oma/group/A0AAA9SHX0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuroblast differentiation", "id": "GO:0014016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014016", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ], "pmid": "" }, { "name": "regulation of neuroblast proliferation", "id": "GO:1902692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902692", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHX9-1", "uniprot_ac": "A0AAA9SHX9", "uniprot_id": "A0AAA9SHX9_BOVIN", "mass": { "chemical_mass": 9556.0, "monoisotopic_mass": 9556.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SHX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SHX9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR033222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14380:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14380:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SHX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSVSPCAYRHRYIFADELYLRSGCPMTWIQTYMYDFIYPVYERIKVVSEQALLFQTELYFPPRDIRYGPQKIPLECSAS", "length": 80, "header": "tr|A0AAA9SHX9-1|A0AAA9SHX9_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SHX9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9/entry#A0AAA9SHX9-1", "sequence": { "sequence": "MVSVSPCAYRHRYIFADELYLRSGCPMTWIQTYMYDFIYPVYERIKVVSEQALLFQTELYFPPRDIRYGPQKIPLECSAS", "length": 80, "header": "tr|A0AAA9SHX9-1|A0AAA9SHX9_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SHX9-1" }, "locus": { "chromosome": "15", "start_pos": 83144355, "end_pos": 83140844, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082132.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SHZ6-1", "uniprot_ac": "A0AAA9SHZ6", "uniprot_id": "A0AAA9SHZ6_BOVIN", "mass": { "chemical_mass": 51501.0, "monoisotopic_mass": 51501.0 }, "refseq": {}, "gene_names": [ { "name": "HYAL3", "type": "recommended", "evidence": [ { "id": "A0AAA9SHZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ] } ], "protein_names": [ { "name": "Hyaluronidase", "type": "recommended", "evidence": [ { "id": "A0AAA9SHZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.35", "type": "synonym", "evidence": [ { "id": "A0AAA9SHZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HYAL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6", "locus": { "chromosome": "22", "start_pos": 50039609, "end_pos": 50033536, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052388", "url": "https://www.ensembl.org/id/ENSBTAG00000052388" } ] } } ], "crossref": [ { "id": "A0AAA9SHZ6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SHZ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052388", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052388", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616562", "url": "https://www.ncbi.nlm.nih.gov/gene/616562", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616562", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616562", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NH73", "url": "https://www.orthodb.org/?gene=A0A3Q1NH73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11769", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11769", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11769:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11769:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01630", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01630", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2024101", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024101", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2160916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NH73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NH73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NH73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NH73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSTKPPGDTIPRPERTPHILDGERHLRLFPGQDAVFLGFHPWGMTMQLGLALVLGVALCLGCGRSLLQAPARPFSVLWNVPSARCKNRFGVPLPLEALGISANRGQHFHGQNVTIFYKNRLGFYPYLGPRGTVHNGGIPQAVPLGCHLARAAHQIRHSLWPGFAGLAVLDWEEWCPLWAGNWGRRQVYRAASWAWAQWVFPNLDPQEQLHKARVGFEQAARALMEDTLWLGRALQPQGLWGFYRFPACGNGWRGTASNYTGHCHAAAVARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRYRLEEAFRVAIAGHPHPLPVLAYARLTHRSSGRFLSLDELVQTIGVSAALGAAGVVLWGDLSFSSSEEECWHLHDYLLGTLGPYVINVTRAAVACSHQRCHGHGRCAWQNPGQLEVFLHLQPDGSPGAWESFSCRCYHGWAGPTCQEPRPELRPEEAP", "length": 464, "header": "tr|A0AAA9SHZ6-1|A0AAA9SHZ6_BOVIN Isoform 1 of Hyaluronidase OS=Bos taurus OX=9913 GN=HYAL3 PE=3 SV=1 CANONICAL=A0AAA9SHZ6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NH73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6/entry#A0A3Q1NH73-1", "sequence": { "sequence": "MTMQLGLALVLGVALCLGCGRSLLQAPARPFSVLWNVPSARCKNRFGVPLPLEALGISANRGQHFHGQNVTIFYKNRLGFYPYLGPRGTVHNGGIPQAVPLGCHLARAAHQIRHSLWPGFAGLAVLDWEEWCPLWAGNWGRRQVYRAASWAWAQWVFPNLDPQEQLHKARVGFEQAARALMEDTLWLGRALQPQGLWGFYRFPACGNGWRGTASNYTGHCHAAAVARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRYRLEEAFRVAIAGHPHPLPVLAYARLTHRSSGRFLSLEECWHLHDYLLGTLGPYVINVTRAAVACSHQRCHGHGRCAWQNPGQLEVFLHLQPDGSPGAWESFSCRCYHGWAGPTCQEPRPELRPEEAP", "length": 389, "header": "tr|A0A3Q1NH73-1|A0A3Q1NH73_BOVIN Computationally mapped isoform of Hyaluronidase OS=Bos taurus OX=9913 GN=HYAL3 PE=3 SV=2 CANONICAL=A0AAA9SHZ6-1" }, "locus": { "chromosome": "22", "start_pos": 50039006, "end_pos": 50037279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067923.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067923.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071272.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071272.2" } ] } }, { "isoform_ac": "A0AAA9SHZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6/entry#A0AAA9SHZ6-1", "sequence": { "sequence": "MAPSTKPPGDTIPRPERTPHILDGERHLRLFPGQDAVFLGFHPWGMTMQLGLALVLGVALCLGCGRSLLQAPARPFSVLWNVPSARCKNRFGVPLPLEALGISANRGQHFHGQNVTIFYKNRLGFYPYLGPRGTVHNGGIPQAVPLGCHLARAAHQIRHSLWPGFAGLAVLDWEEWCPLWAGNWGRRQVYRAASWAWAQWVFPNLDPQEQLHKARVGFEQAARALMEDTLWLGRALQPQGLWGFYRFPACGNGWRGTASNYTGHCHAAAVARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRYRLEEAFRVAIAGHPHPLPVLAYARLTHRSSGRFLSLDELVQTIGVSAALGAAGVVLWGDLSFSSSEEECWHLHDYLLGTLGPYVINVTRAAVACSHQRCHGHGRCAWQNPGQLEVFLHLQPDGSPGAWESFSCRCYHGWAGPTCQEPRPELRPEEAP", "length": 464, "header": "tr|A0AAA9SHZ6-1|A0AAA9SHZ6_BOVIN Isoform 1 of Hyaluronidase OS=Bos taurus OX=9913 GN=HYAL3 PE=3 SV=1 CANONICAL=A0AAA9SHZ6-1" }, "locus": { "chromosome": "22", "start_pos": 50039006, "end_pos": 50033735, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127623.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127623.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085852.1" } ] } }, { "isoform_ac": "A0AAA9T5Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6/entry#A0AAA9T5Z2-1", "sequence": { "sequence": "MTMQLGLALVLGVALCLGCGRSLLQAPARPFSVLWNVPSARCKNRFGVPLPLEALGISANRGQHFHGQNVTIFYKNRLGFYPYLGPRGTVHNGGIPQAVPLGCHLARAAHQIRHSLWPGFAGLAVLDWEEWCPLWAGNWGRRQVYRAASWAWAQWVFPNLDPQEQLHKARVGFEQAARALMEDTLWLGRALQPQGLWGFYRFPACGNGWRGTASNYTGHCHAAAVARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRYRLEEAFRVAIAGHPHPLPVLAYARLTHRSSGRFLSLDELVQTIGVSAALGAAGVVLWGDLSFSSSEEECWHLHDYLLGTLGPYVINVTRAAVACSHQRCHGHGRCAWQNPGQLEVFLHLQPDGSPGAWESFSCRCYHGWAGPTCQEPRPELRPEEAP", "length": 419, "header": "tr|A0AAA9T5Z2-1|A0AAA9T5Z2_BOVIN Computationally mapped isoform of Hyaluronidase OS=Bos taurus OX=9913 GN=HYAL3 PE=3 SV=2 CANONICAL=A0AAA9SHZ6-1" }, "locus": { "chromosome": "22", "start_pos": 50039006, "end_pos": 50037279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091980.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091980.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:616562", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616562", "resource": "KEGG Pathway" }, { "id": "R-BTA-2024101", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024101", "resource": "Reactome", "description": "CS/DS degradation" }, { "id": "R-BTA-2160916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "resource": "Reactome", "description": "Hyaluronan degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "cellular response to UV-B", "id": "GO:0071493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071493", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "negative regulation of ovarian follicle development", "id": "GO:2000355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "response to antibiotic", "id": "GO:0046677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "penetration of zona pellucida", "id": "GO:0007341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007341", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "cartilage development", "id": "GO:0051216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "cellular response to interleukin-1", "id": "GO:0071347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071347", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "positive regulation of acrosomal vesicle exocytosis", "id": "GO:2000368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000368", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "hyaluronan catabolic process", "id": "GO:0030214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "ovarian follicle atresia", "id": "GO:0001552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "acrosomal membrane", "id": "GO:0002080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hyalurononglucosaminidase activity", "id": "GO:0004415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004415", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" }, { "name": "hyaluronoglucuronidase activity", "id": "GO:0033906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033906", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1793209", "name": "HYAL1-4 hydrolyze chondroitin chains", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-2065212" ], "enzyme_list": [ "E1B8K4-1", "F1MSK8-1", "A0AAA9SHZ6-1" ], "evidence": [ { "id": "R-BTA-1793209", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1793209" } ] }, { "id": "R-BTA-2160874", "name": "HYAL1 hydrolyses (HA)50", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2160864" ], "output_participant_list": [ "R-ALL-2160866" ], "enzyme_list": [ "E1B8K4-1", "F1MSK8-1", "A0AAA9SHZ6-1" ], "evidence": [ { "id": "R-BTA-2160874", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160874" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2065212", "participant_name": "CS/HS precursor [lysosomal lumen]", "crossref": [ { "id": "747385", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2160864", "participant_name": "(HA)50 [lysosomal lumen]", "crossref": [ { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" } ] }, { "participant_id": "R-ALL-2160866", "participant_name": "(HA)2 [lysosomal lumen]", "crossref": [ { "id": "64024", "database": "ChEBI", "url": "" }, { "id": "G35674CY", "database": "GlyTouCan", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SHZ6", "gene_name": "HYAL3", "activity": [ { "ec_number": "3.2.1.35", "activity": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "A0AAA9SHZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ] }, { "ec_number": "3.2.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SHZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" } ] } ] }, { "uniprot_ac": "E1B8K4", "gene_name": "HYAL4", "activity": [ { "ec_number": "3.2.1.35", "activity": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "E1B8K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8K4" } ] }, { "ec_number": "3.2.1.35", "activity": "", "evidence": [ { "id": "E1B8K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8K4" } ] } ] }, { "uniprot_ac": "F1MSK8", "gene_name": "HYAL1", "activity": [ { "ec_number": "3.2.1.35", "activity": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "F1MSK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSK8" } ] }, { "ec_number": "3.2.1.35", "activity": "", "evidence": [ { "id": "F1MSK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSK8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SHZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHZ6" }, { "id": "PS00022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00022" }, { "id": "PS01186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 440, "end_pos": 451, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.35", "ec_name": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "3.2.1.35", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.35" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 393, "end_pos": 395 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI06-1", "uniprot_ac": "A0AAA9SI06", "uniprot_id": "A0AAA9SI06_BOVIN", "mass": { "chemical_mass": 9928.0, "monoisotopic_mass": 9928.0 }, "refseq": { "ac": "XP_024836709", "name": "keratin-associated protein 17-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836709" }, "gene_names": [ { "name": "KRTAP17-1", "type": "recommended", "evidence": [ { "id": "A0AAA9SI06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06" } ] }, { "name": "KRTAP17-1", "type": "synonym", "evidence": [ { "id": "XP_024836709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836709" } ] } ], "protein_names": [ { "name": "Keratin associated protein 17-1", "type": "synonym", "evidence": [ { "id": "A0AAA9SI06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06/entry#names_and_taxonomy" } ] }, { "name": "keratin-associated protein 17-1", "type": "synonym", "evidence": [ { "id": "XP_024836709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836709" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTAP17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06", "locus": { "chromosome": "19", "start_pos": 41527379, "end_pos": 41527714, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063685", "url": "https://www.ensembl.org/id/ENSBTAG00000063685" } ] } } ], "crossref": [ { "id": "A0AAA9SI06", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI06", "database": "AlphaFoldDB", "categories": [] }, { "id": "100297004", "url": "https://www.ncbi.nlm.nih.gov/gene/100297004", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:100297004", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297004", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024836709", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836709", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SI06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCCPGDCFGCCGEEQDCCEVCCCQPSCCGCCGSCCGSCCGCGSGCGGCGGSCCGSSCCGSGCGGGGGCGGCGGCGSCGSCCGSCCGSGCCGSSGCCGPVCCQPTPVCETK", "length": 111, "header": "tr|A0AAA9SI06-1|A0AAA9SI06_BOVIN Isoform 1 of Keratin associated protein 17-1 OS=Bos taurus OX=9913 GN=KRTAP17-1 PE=4 SV=1 CANONICAL=A0AAA9SI06-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI06/entry#A0AAA9SI06-1", "sequence": { "sequence": "MGCCPGDCFGCCGEEQDCCEVCCCQPSCCGCCGSCCGSCCGCGSGCGGCGGSCCGSSCCGSGCGGGGGCGGCGGCGSCGSCCGSCCGSGCCGSSGCCGPVCCQPTPVCETK", "length": 111, "header": "tr|A0AAA9SI06-1|A0AAA9SI06_BOVIN Isoform 1 of Keratin associated protein 17-1 OS=Bos taurus OX=9913 GN=KRTAP17-1 PE=4 SV=1 CANONICAL=A0AAA9SI06-1" }, "locus": { "chromosome": "19", "start_pos": 41527714, "end_pos": 41527382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128657.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128657.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082163.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082163.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297004", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297004", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI20-1", "uniprot_ac": "A0AAA9SI20", "uniprot_id": "A0AAA9SI20_BOVIN", "mass": { "chemical_mass": 66687.0, "monoisotopic_mass": 66687.0 }, "refseq": {}, "gene_names": [ { "name": "ATXN10", "type": "recommended", "evidence": [ { "id": "A0AAA9SI20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ] } ], "protein_names": [ { "name": "Ataxin-10", "type": "recommended", "evidence": [ { "id": "A0AAA9SI20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20/entry#names_and_taxonomy" } ] }, { "name": "Spinocerebellar ataxia type 10 protein homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SI20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20#function" }, { "database": "UniProtKB", "id": "ARBA00045173", "url": "https://www.uniprot.org/uniprotkb/ARBA00045173#function" }, { "database": "UniProtKB", "id": "F1MH20", "url": "https://www.uniprot.org/uniprotkb/F1MH20#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATXN10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20", "locus": { "chromosome": "5", "start_pos": 116169393, "end_pos": 116028127, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009351", "url": "https://www.ensembl.org/id/ENSBTAG00000009351" } ] } } ], "crossref": [ { "id": "A0AAA9SI20", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009351", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009351", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13255", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13255", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13255:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13255:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH20", "url": "https://www.uniprot.org/uniprotkb/F1MH20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH20-1", "url": "https://www.uniprot.org/uniprotkb/F1MH20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METLSVPIAPLRVSPFRGHPSDFSLGALRPPDVPTPANTTSARAPSPQGELPAGAPLPAGGTSARAPSPRRAVASSGLRRGLGAWSRAFPAGPAGCSGAEAAAAACGGSSPRSLPPALLPLLLRLLVVGRSARAASGKMAAPRPPPGRLSGVMMPAPIQDLEALRALTALFKEQRNRDTAPRTIFQRVLDILKKSSHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLGTIGVAVDLILLFRELRVEQDSLLTAFRCGLQFLGNIASRNEDSQSVVWMHAFPELFLSCLNHPDRKIVAYSSMILFTSLNSERMKELEENLNIAIDVVEAHQKQPESEWPFLIITDHFLKSPELVKAMYAKMSNQERVTLLDLMIAKIVGDEPLTKDDAPVFLSHAELIASTFVDQCKIVLKLTSEQHTDDEEALATIRLLDVLCEMTANTDLLGYLQVFPGLLERVIDLLRLIHVAGNDSTNIFSACASIKADGDVSSVAEGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDSCGLDDSNPFLTQWVVYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKMGFEVEKRGDKLILKSTSDTPQL", "length": 613, "header": "tr|A0AAA9SI20-1|A0AAA9SI20_BOVIN Isoform 1 of Ataxin-10 OS=Bos taurus OX=9913 GN=ATXN10 PE=3 SV=1 CANONICAL=A0AAA9SI20-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20/entry#A0AAA9SI20-1", "sequence": { "sequence": "METLSVPIAPLRVSPFRGHPSDFSLGALRPPDVPTPANTTSARAPSPQGELPAGAPLPAGGTSARAPSPRRAVASSGLRRGLGAWSRAFPAGPAGCSGAEAAAAACGGSSPRSLPPALLPLLLRLLVVGRSARAASGKMAAPRPPPGRLSGVMMPAPIQDLEALRALTALFKEQRNRDTAPRTIFQRVLDILKKSSHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLGTIGVAVDLILLFRELRVEQDSLLTAFRCGLQFLGNIASRNEDSQSVVWMHAFPELFLSCLNHPDRKIVAYSSMILFTSLNSERMKELEENLNIAIDVVEAHQKQPESEWPFLIITDHFLKSPELVKAMYAKMSNQERVTLLDLMIAKIVGDEPLTKDDAPVFLSHAELIASTFVDQCKIVLKLTSEQHTDDEEALATIRLLDVLCEMTANTDLLGYLQVFPGLLERVIDLLRLIHVAGNDSTNIFSACASIKADGDVSSVAEGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDSCGLDDSNPFLTQWVVYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKMGFEVEKRGDKLILKSTSDTPQL", "length": 613, "header": "tr|A0AAA9SI20-1|A0AAA9SI20_BOVIN Isoform 1 of Ataxin-10 OS=Bos taurus OX=9913 GN=ATXN10 PE=3 SV=1 CANONICAL=A0AAA9SI20-1" }, "locus": { "chromosome": "5", "start_pos": 116168600, "end_pos": 116028326, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112979.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112979.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083538.1" } ] } }, { "isoform_ac": "F1MH20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20/entry#F1MH20-1", "sequence": { "sequence": "MAAPRPPPGRLSGVMMPAPIQDLEALRALTALFKEQRNRNLGTIGVAVDLILLFRELRVEQDSLLTAFRCGLQFLGNIASRNEDSQSVVWMHAFPELFLSCLNHPDRKIVAYSSMILFTSLNSERMKELEENLNIAIDVVEAHQKQPESEWPFLIITDHFLKSPELVKAMYAKMSNQERVTLLDLMIAKIVGDEPLTKDDAPVFLSHAELIASTFVDQCKIVLKLTSEQHTDDEEALATIRLLDVLCEMTANTDLLGYLQVFPGLLERVIDLLRLIHVAGNDSTNIFSACASIKADGDVSSVAEGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDSCGLDDSNPFLTQWVVYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKMGFEVEKRGDKLILKSTSDTPQL", "length": 411, "header": "tr|F1MH20-1|A0AAA9SI20_BOVIN Computationally mapped isoform of Ataxin-10 OS=Bos taurus OX=9913 GN=ATXN10 PE=3 SV=2 CANONICAL=A0AAA9SI20-1" }, "locus": { "chromosome": "5", "start_pos": 116168600, "end_pos": 116028740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012308.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012308.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012308.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012308.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 562, "end_pos": 564, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SI20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI20" }, { "id": "PF09759", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09759" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ataxin-10", "eco_id": "ECO_0000259", "start_pos": 508, "end_pos": 598, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 }, { "start_pos": 483, "end_pos": 485 }, { "start_pos": 562, "end_pos": 564 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI75-1", "uniprot_ac": "A0AAA9SI75", "uniprot_id": "A0AAA9SI75_BOVIN", "mass": { "chemical_mass": 11613.0, "monoisotopic_mass": 11613.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112445860", "type": "recommended", "evidence": [ { "id": "A0AAA9SI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75" } ] } ], "protein_names": [ { "name": "Protein S100", "type": "recommended", "evidence": [ { "id": "A0AAA9SI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112445860", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75", "locus": {} } ], "crossref": [ { "id": "A0AAA9SI75", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI75", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112445860", "url": "https://www.ncbi.nlm.nih.gov/gene/112445860", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112445860", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445860", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:786350", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786350", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RHYLSNI", "url": "https://omabrowser.org/oma/group/RHYLSNI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002686048", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686048", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SI75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGFHLEQAITDLINLFHKYSGSDDTIEKEDLLRLMKENFPNFLSACEKRGRQYLSDIFEKKDKNKDKKIDFSEFLSLLADIATDYHNHSHGAQLCSGGNQ", "length": 101, "header": "tr|A0AAA9SI75-1|A0AAA9SI75_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=LOC112445860 PE=3 SV=1 CANONICAL=A0AAA9SI75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75/entry#A0AAA9SI75-1", "sequence": { "sequence": "MSGFHLEQAITDLINLFHKYSGSDDTIEKEDLLRLMKENFPNFLSACEKRGRQYLSDIFEKKDKNKDKKIDFSEFLSLLADIATDYHNHSHGAQLCSGGNQ", "length": 101, "header": "tr|A0AAA9SI75-1|A0AAA9SI75_BOVIN Isoform 1 of Protein S100 OS=Bos taurus OX=9913 GN=LOC112445860 PE=3 SV=1 CANONICAL=A0AAA9SI75-1" }, "locus": { "chromosome": "3", "start_pos": 17039803, "end_pos": 17038569, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130404.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130404.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083445.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112445860", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445860", "resource": "KEGG Pathway" }, { "id": "bta:786350", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786350", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transition metal ion binding", "id": "GO:0046914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SI75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI75" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 85, "start_aa": "Arg", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI82-1", "uniprot_ac": "A0AAA9SI82", "uniprot_id": "A0AAA9SI82_BOVIN", "mass": { "chemical_mass": 40451.0, "monoisotopic_mass": 40451.0 }, "refseq": { "ac": "XP_024844000", "name": "zinc finger protein 75 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844000" }, "gene_names": [ { "name": "LOC614260", "type": "recommended", "evidence": [ { "id": "A0AAA9SI82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" } ] }, { "name": "LOC614260", "type": "synonym", "evidence": [ { "id": "XP_024844000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844000" } ] }, { "name": "ZNF75", "type": "synonym", "evidence": [ { "id": "XP_024844000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844000" } ] } ], "protein_names": [ { "name": "Zinc finger protein 75D", "type": "recommended", "evidence": [ { "id": "A0AAA9SI82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 75 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024844000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844000" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC614260", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82", "locus": {} } ], "crossref": [ { "id": "A0AAA9SI82", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI82", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614260", "url": "https://www.ncbi.nlm.nih.gov/gene/614260", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844000", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844000", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SI82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQIEEKLFPEQIMMSPVKAPACLYPHVEVLQGTKRSVKESSNKSKKSSPQMGSLHPESARQHFRSFCYHDTPGPFEAVSQLQELCSQWLRPEIHSKEQILELLVLEQFLDVLPSHIQNWVQKYHPQNVKEAVALVDRFHRECGGISNEVTTHQLGNDTALLGGTAVAPGFKWKPAEPQPMGVFQEECSNIYQVLQEPRWNTHKESQPVDKGAVPAEESPTFSEEKSTPSWKLTSKLTLPKSQSPLTFEDVALYFSEEEWKIMTPDEKTLYLDVMQELYEDVASVGLKLTNDPENDPPVSLPTLEIQPSGCEVLGKATMKDAETTVGKENHGDTCRVRKRPRSPEAPALASHFVAGDKLH", "length": 360, "header": "tr|A0AAA9SI82-1|A0AAA9SI82_BOVIN Isoform 1 of Zinc finger protein 75D OS=Bos taurus OX=9913 GN=LOC614260 PE=4 SV=1 CANONICAL=A0AAA9SI82-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82/entry#A0AAA9SI82-1", "sequence": { "sequence": "MSQIEEKLFPEQIMMSPVKAPACLYPHVEVLQGTKRSVKESSNKSKKSSPQMGSLHPESARQHFRSFCYHDTPGPFEAVSQLQELCSQWLRPEIHSKEQILELLVLEQFLDVLPSHIQNWVQKYHPQNVKEAVALVDRFHRECGGISNEVTTHQLGNDTALLGGTAVAPGFKWKPAEPQPMGVFQEECSNIYQVLQEPRWNTHKESQPVDKGAVPAEESPTFSEEKSTPSWKLTSKLTLPKSQSPLTFEDVALYFSEEEWKIMTPDEKTLYLDVMQELYEDVASVGLKLTNDPENDPPVSLPTLEIQPSGCEVLGKATMKDAETTVGKENHGDTCRVRKRPRSPEAPALASHFVAGDKLH", "length": 360, "header": "tr|A0AAA9SI82-1|A0AAA9SI82_BOVIN Isoform 1 of Zinc finger protein 75D OS=Bos taurus OX=9913 GN=LOC614260 PE=4 SV=1 CANONICAL=A0AAA9SI82-1" }, "locus": { "chromosome": "X", "start_pos": 19055487, "end_pos": 19046720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124115.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124115.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083612.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083612.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SI82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 246, "end_pos": 327, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SI82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI82" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 142, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SF96-1", "uniprot_ac": "A0AAA9SF96", "uniprot_id": "A0AAA9SF96_BOVIN", "mass": { "chemical_mass": 217314.0, "monoisotopic_mass": 217314.0 }, "refseq": {}, "gene_names": [ { "name": "ASPM", "type": "recommended", "evidence": [ { "id": "A0AAA9SF96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ] } ], "protein_names": [ { "name": "Assembly factor for spindle microtubules", "type": "synonym", "evidence": [ { "id": "A0AAA9SF96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis.", "evidence": [ { "database": "UniProtKB", "id": "F1MM80", "url": "https://www.uniprot.org/uniprotkb/F1MM80#function" }, { "database": "UniProtKB", "id": "ARBA00059155", "url": "https://www.uniprot.org/uniprotkb/ARBA00059155#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASPM", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96", "locus": { "chromosome": "16", "start_pos": 76021939, "end_pos": 76082265, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007860", "url": "https://www.ensembl.org/id/ENSBTAG00000007860" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007860", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007860", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23766", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23766", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534849", "url": "https://www.ncbi.nlm.nih.gov/gene/534849", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534849", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534849", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSHWRAT", "url": "https://omabrowser.org/oma/group/QSHWRAT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MM80", "url": "https://www.orthodb.org/?gene=F1MM80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22706", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22706", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22706:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22706:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM80", "url": "https://www.uniprot.org/uniprotkb/F1MM80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM80-1", "url": "https://www.uniprot.org/uniprotkb/F1MM80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ATWQRGSGCWERSPPEPRPRAGPRGPRAEEEAASPAVLSLSHFCRSPFLCFGDVRLGASRTLPLILDNPNEEAAAVWLSRGPAAERGFTIWPSAFVLQPKEKIVVSITWTPLKGGRIRETITFLVNDILKHQAILLGNAEEPKKKKRTLWDTINKKKASASSRHNKKASNIQNVNKTFNVSPKADRVRSPLQACENLATNGNCSPPESNPLILEENKLPISPISPASQECHRGTCLPLPVRRSTTYTSLPASENGGLVKADGANTAEDFHFNEKGITETSFDSIDNVNSQIEENGKLTLTPNYSSSLNITQSQGHFLSPDSFVNNSHASNNEPEFVKCLSPDMFVKGNTRPVILESKRVHEICRKILSPDSFINDNYGLNEDLETESINPILSPNQFLKDNMAYICVSQQTCQLPLSTGHFQDSQPPQDERKNAAVPCISECQQLESPKATFEASKALEVMSNSYTFKKQNQPKFSAVQDISSHSRKKPIKRRPILSATVTKRKPTCAVENQMETVKPKAKRCLNVVVGDCKKETDDQKEKDDFHPFLPIRDLIQSRPKSSKNIVTPPCKVASVARKRKSEGHTGDENVRITVTECMEAQEVKRPHFSPVESKTSTVKHTKKVVTSSLKRVSHREKLNLKKKTDSLGYRTPKTNRRTRPFVPVAQSNLTFIKPLKGIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNASTLLLGVESQHKVSVPKAPTKDEVSLRAYTARCRLNRLRRAACRLFTSEKMVKAMKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELVPLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPSVPHLYRDGHEEALSKFTLKKLLLLICFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLGGEGDLSRHLSLLGFPVTHVQMPFDEFDFAVKNLAVDLQCGVRLVRTMELLTQNWNLSKKLRIPAISRLQKMHNVDIVLEILKSRGIQLNDEHGNAILSKDIVDRHREKTLALLWKIALAFQVDISLNLDQLKEEIDFLKNTQSTKKTMSALSCRPDAVISKKRDERHSGPFEQCSESVKLLMDWVNAVCGFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTHTGSVVLNSSSESDGSFLDFSLKPPDQENTSELYKELLENEKKNFQLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKETRAARLIQTTWRQYKLKKDLKHHEERDKAARIIQSAIINFLTKQRFKKKVSAALVIQKYWRRALAKRKLLMLKKEKLERVHSKSASIIQAVWRRHKARKYLREVKAACRIQAWYRCWKARREYLAVLRAVRIIQRCFCTQQQRRRFLNVRASAVIIQRRWRTVLSGRTTHEQSLMTKRHQAACLIQANFRGYKARQAFLQQKSAALTIQRYIRARKAGKHQRMKYVELKKSTVVLQALVRGWLVRKRISEQRAKIRLLHFAAAAFYHLSALRIQRAYRRHVALKHANNKQLNSAICIQRWFRARSQRKRFLQKYSIINIQREAREQARQRSRAASVIQRAVRRFLLRKKQENCNKRIAKIQALWRGYSWRKKNDSTKTKAIRQRLQCVNREIREESKLYHRTAVALHHLLTYKYLSTVLEALKHLEAVTRLSSICCEKMAQSGAISKIFVLIRSCNRSVPCMEVIRYAMQVLLNVAKYEKTTSAIYDVENCVDTLLELMQMYQEKSGDKVADKSRSIFTKTCCLLAVLLKTTTRALDVQSRSKVVDRIYSLYKLTAHKHKVNTERILCKQKKNSSVSLSFFPETPVRTTMVSRLKPDWVLRRDNVEEVMTPLQAIQMVLDTLSLPY", "length": 1892, "header": "tr|A0AAA9SF96-1|A0AAA9SF96_BOVIN Isoform 1 of Assembly factor for spindle microtubules OS=Bos taurus OX=9913 GN=ASPM PE=4 SV=1 CANONICAL=A0AAA9SF96-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96/entry#A0AAA9SF96-1", "sequence": { "sequence": "ATWQRGSGCWERSPPEPRPRAGPRGPRAEEEAASPAVLSLSHFCRSPFLCFGDVRLGASRTLPLILDNPNEEAAAVWLSRGPAAERGFTIWPSAFVLQPKEKIVVSITWTPLKGGRIRETITFLVNDILKHQAILLGNAEEPKKKKRTLWDTINKKKASASSRHNKKASNIQNVNKTFNVSPKADRVRSPLQACENLATNGNCSPPESNPLILEENKLPISPISPASQECHRGTCLPLPVRRSTTYTSLPASENGGLVKADGANTAEDFHFNEKGITETSFDSIDNVNSQIEENGKLTLTPNYSSSLNITQSQGHFLSPDSFVNNSHASNNEPEFVKCLSPDMFVKGNTRPVILESKRVHEICRKILSPDSFINDNYGLNEDLETESINPILSPNQFLKDNMAYICVSQQTCQLPLSTGHFQDSQPPQDERKNAAVPCISECQQLESPKATFEASKALEVMSNSYTFKKQNQPKFSAVQDISSHSRKKPIKRRPILSATVTKRKPTCAVENQMETVKPKAKRCLNVVVGDCKKETDDQKEKDDFHPFLPIRDLIQSRPKSSKNIVTPPCKVASVARKRKSEGHTGDENVRITVTECMEAQEVKRPHFSPVESKTSTVKHTKKVVTSSLKRVSHREKLNLKKKTDSLGYRTPKTNRRTRPFVPVAQSNLTFIKPLKGIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNASTLLLGVESQHKVSVPKAPTKDEVSLRAYTARCRLNRLRRAACRLFTSEKMVKAMKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELVPLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPSVPHLYRDGHEEALSKFTLKKLLLLICFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLGGEGDLSRHLSLLGFPVTHVQMPFDEFDFAVKNLAVDLQCGVRLVRTMELLTQNWNLSKKLRIPAISRLQKMHNVDIVLEILKSRGIQLNDEHGNAILSKDIVDRHREKTLALLWKIALAFQVDISLNLDQLKEEIDFLKNTQSTKKTMSALSCRPDAVISKKRDERHSGPFEQCSESVKLLMDWVNAVCGFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTHTGSVVLNSSSESDGSFLDFSLKPPDQENTSELYKELLENEKKNFQLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKETRAARLIQTTWRQYKLKKDLKHHEERDKAARIIQSAIINFLTKQRFKKKVSAALVIQKYWRRALAKRKLLMLKKEKLERVHSKSASIIQAVWRRHKARKYLREVKAACRIQAWYRCWKARREYLAVLRAVRIIQRCFCTQQQRRRFLNVRASAVIIQRRWRTVLSGRTTHEQSLMTKRHQAACLIQANFRGYKARQAFLQQKSAALTIQRYIRARKAGKHQRMKYVELKKSTVVLQALVRGWLVRKRISEQRAKIRLLHFAAAAFYHLSALRIQRAYRRHVALKHANNKQLNSAICIQRWFRARSQRKRFLQKYSIINIQREAREQARQRSRAASVIQRAVRRFLLRKKQENCNKRIAKIQALWRGYSWRKKNDSTKTKAIRQRLQCVNREIREESKLYHRTAVALHHLLTYKYLSTVLEALKHLEAVTRLSSICCEKMAQSGAISKIFVLIRSCNRSVPCMEVIRYAMQVLLNVAKYEKTTSAIYDVENCVDTLLELMQMYQEKSGDKVADKSRSIFTKTCCLLAVLLKTTTRALDVQSRSKVVDRIYSLYKLTAHKHKVNTERILCKQKKNSSVSLSFFPETPVRTTMVSRLKPDWVLRRDNVEEVMTPLQAIQMVLDTLSLPY", "length": 1892, "header": "tr|A0AAA9SF96-1|A0AAA9SF96_BOVIN Isoform 1 of Assembly factor for spindle microtubules OS=Bos taurus OX=9913 GN=ASPM PE=4 SV=1 CANONICAL=A0AAA9SF96-1" }, "locus": { "chromosome": "16", "start_pos": 76082063, "end_pos": 76022097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123684.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123684.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084844.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084844.1" } ] } }, { "isoform_ac": "F1MM80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96/entry#F1MM80-1", "sequence": { "sequence": "MATWQRGSGCWERSPPEPRPRAGPRGPRAEEEAASPAVLSLSHFCRSPFLCFGDVRLGASRTLPLILDNPNEEAAAVWLSRGPAAERGFTIWPSAFVLQPKEKIVVSITWTPLKGGRIRETITFLVNDILKHQAILLGNAEEPKKKKRTLWDTINKKKASASSRHNKKASNIQNVNKTFNVSPKADRVRSPLQACENLATNGNCSPPESNPLILEENKLPISPISPASQECHRGTCLPLPVRRSTTYTSLPASENGGLVKADGANTAEDFHFNEKGITETSFDSIDNVNSQIEENGKLTLTPNYSSSLNITQSQGHFLSPDSFVNNSHASNNEPEFVKCLSPDMFVKGNTRPVILESKRVHEICRKILSPDSFINDNYGLNEDLETESINPILSPNQFLKDNMAYICVSQQTCQLPLSTGHFQDSQPPQDERKNAAVPCISECQQLESPKATFEASKALEVMSNSYTFKKQNQPKFSAVQDISSHSRKKPIKRRPILSATVTKRKPTCAVENQMETVKPKAKRCLNVVVGDCKKETDDQKEKDDFHPFLPIRDLIQSRPKSSKNIVTPPCKVASVARKRKSEGHTGDENVRITVTECMEAQEVKRPHFSPVESKTSTVKHTKKVVTSSLKRVSHREKLNLKKKTDSLGYRTPKTNRRTRPFVPVAQSNLTFIKPLKGIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNASTLLLGVESQHKVSVPKAPTKDEVSLRAYTARCRLNRLRRAACRLFTSEKMVKAMKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELVPLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPSVPHLYRDGHEEALSKFTLKKLLLLICFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLGGEGDLSRHLSLLGFPVTHVQMPFDEFDFAVKNLAVDLQCGVRLVRTMELLTQNWNLSKKLRIPAISRLQKMHNVDIVLEILKSRGIQLNDEHGNAILSKDIVDRHREKTLALLWKIALAFQVDISLNLDQLKEEIDFLKNTQSTKKTMSALSCRPDAVISKKRDERHSGPFEQCSESVKLLMDWVNAVCGFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTHTGSVVLNSSSESDGSFLDFSLKPPDQENTSELYKELLENEKKNFQLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKETRAARLIQTTWRQYKLKKDLKHHEERDKAARIIQSAIINFLTKQRFKKKVSAALVIQKYWRRALAKRKLLMLKKEKLERVHSKSASIIQRHWRRYSTRKQFLKLKYYSIFLQSKIRMIIAVASYKRYHWATVTIQRRWRAHVRSKQDRQRYELLRSSTLVIQFAFRRWRRRKRQSQINAAITLQRAFRQWHVRKCAQEERAAVVIQSWYRMHRELRKYIHLRSCVIIIQARFRCFQAQKLYTRTRESILTLQKHYRAYVKGKVECTGYLQKRAAAIRLQAAFRGRRARNLYRQIKAACVLQSYWRMRQDRLRFLNLKKNIIRLQAHIRRRQQLHTYQKMKKAALIIQIHFRAYMSAKEVLASYQKTRSAVIVLQSACRRMQARKKFLHILTSIVKIQSYYRAYASRRKFLRLKKATVKLQSIVRMKLARKQYLHLRAIAQQREEHRRASCIKLQAFLRGYLVRKQVRLQRKAAVSLQSYFRMRKMRLDYLKVCHTAVVIQRYYRAHRAGAQQRKHFLQVRRAVTCLQATYRGYKVRRQLQQQSSAALKIQAAFRGYRQRTKYQSVLQSAFKIQRWYRTHKTVSAIRSHFFKTRTAAISLQSAYRGWKVRKQMRKEHEAAVKIQSAFRTARAQKEFRVLKTAASVIQQHLRARAAGRRQRTEYMALRRAAVMLQSAWRGRAARRRIQKQQRCAIIIQAYYRRHVQRKRWEIMKKAAHLIQMHYRAYRTGRKQHHLFLKTKAAAIILQSAFRGVRVRKKVKEMHQAAATIQSRYRAYQARKKYASYRAAAVIIQRWYRAAKLAGRQREEYLAVKKAALKIQAVYRGVRARRQIRRMHTAATLIKATFKMQQSRRRYQQMRTAAIIIQVRYRAYRQGRAQRAKYLTILKAVALLQAALRGARVRQSLRRMRTAATLIQAHYRGRRQQAYFNKLKKVTKTVQQKYRAARERHAQLRRYNQLRRSAICIQAAFRGMRARRRLKAMHSAAAVIQRRFRTLGMRRRFLSLRKTAVWVQRKYRAKVCTRHHVQQLRLQKAAIKIQSWYRGWMVRKKIQEMRRAATILQAAFRRHRTRARYQAWRCASQVIQQRFRAGRAARLQRRQYLQQRHSALVLQAAFRGMRVRRRLKRMHVSATLIQSRFRSIMRRKRFLSLKKAAVFVQRKYRATICAKHHLHRFLELQKAIIIIQASYRRRMVKKQLQEMHRAAALIQASFRMHRARLAFQTWKHAAVLIQQRYRACRAAKLQRALYIRWRHSAVVIQAAYKGLKARQLLREKHRAAVIIQSTYRMYRQHFFYQKLQWATKVIQERYRASKRKALQHDALKAATCARAGFQDMVVRRLIEERRHQAAITIQEHFRAFKTRKHYLHFRAKVVFVQRRYRELMAVRTQAVICIQSCFRGFKARRGIQRMHLAATRIQSCYRRHRARADYQAKKRAVVVIQNHYRSYIRVKMERKEFLAIQKSAPTIQAAFRGMKVRQKLKTMPDKKMAAPATQPAFYCHRTESQHEAGHSPALVAQGLYKTSLVGPSQETEQHSQRKAAVTIQKAFHKMVTRRLEKQRRAAVRIQSFLQMAVYRRRFLQQKRAALTLQRCFRIQQSRKQFLLYREAAVGLQNPHRASLPAKHQRELYLQIRSSVIIIQARVKGFIQKRKFRELKDSTIKIQAVWRRHKARKYLREVKAACRIQAWYRCWKARREYLAVLRAVRIIQRCFCTQQQRRRFLNVRASAVIIQRRWRTVLSGRTTHEQSLMTKRHQAACLIQANFRGYKARQAFLQQKSAALTIQRYIRARKAGKHQRMKYVELKKSTVVLQALVRGWLVRKRISEQRAKIRLLHFAAAAFYHLSALRIQRAYRRHVALKHANNKQLNSAICIQRWFRARSQRKRFLQKYSIINIQREAREQARQRSRAASVIQRAVRRFLLRKKQENCNKRIAKIQALWRGYSWRKKNDSTKTKAIRQRLQCVNREIREESKLYHRTAVALHHLLTYKYLSTVLEALKHLEAVTRLSSICCEKMAQSGAISKIFVLIRSCNRSVPCMEVIRYAMQVLLNVAKYEKTTSAIYDVENCVDTLLELMQMYQEKSGDKVADKSRSIFTKTCCLLAVLLKTTTRALDVQSRSKVVDRIYSLYKLTAHKHKVNTERILCKQKKNSSVSLSFFPETPVRTTMVSRLKPDWVLRRDNVEEVMTPLQAIQMVLDTLSLPY", "length": 3461, "header": "tr|F1MM80-1|F1MM80_BOVIN Computationally mapped isoform of Abnormal spindle-like microcephaly-associated protein homolog OS=Bos taurus OX=9913 GN=ASPM PE=4 SV=3 CANONICAL=A0AAA9SF96-1" }, "locus": { "chromosome": "16", "start_pos": 76082066, "end_pos": 76022097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010340.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010340.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010340.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010340.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534849", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534849", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B8W4-1", "protein_name": "Abnormal spindle-like microcephaly-associated protein isoform X1", "gene_name": "aspm", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSFKVAKSECLDFSPPLDSHCSRDKSGKENSSSIPVLSLLQFSRAPFVSFGTIKLGSSKSLPLRIENPTDDATATVIVDKISASKGFSVDQMSFTIQPEDSIILTVTWTPVEEGGIRELLCFIANGIVKHQAILLGKAETTKKKKKTLWDSIKSKKGVPAPSKEKKVSTMPIKSVNKTFHVSRQSQYRKDRTSNPLSPLNQNGSRRVNTPSSTPEMPKPAFITETFDNVHLQKDSPVVVLVPAERLLDTPGKKDAPSSRQIECREITRVLNKTLSPASTPERFRNPLSSGFQSPLPVIGQFVQDKSREPEKLSLSVKDALDVIGSDLSHTVSPPNACSSFDFSDSLESDKPDPGASFRARRVISPPVETADPRLTFCVKPNKAIGIASNQDEFRLKALPFSTATVTKSIKVDDTHVPDDPKTFPVNSATVVKSKADASVESPGLRKKKTSRRRLLEKTLELSEPSNAESNTSSPDSFSALPVINSDSSPDLPLESKICPVAKKKPTLNLSPHDQLLSSISPIRPQVFPSVSNSPSSSLELSASHFSEKVKPNLLENQFPVQSRTLVQSKKRKSDEFLRGHSEDKSNIQAKKCRAPAQATEKPSQERTLTSRSTSGPQRKAVAPPSSRKFTRFPPKKISPKTAQKDARSVKSANSSTRKTARIVAVAQARLTFMKPTQTAIPRHPLPFAAKNMFYDERWIEKQERGFTWWMNYILTPDDFKVATEVTKVNALSLTMGNDKFNIPKAPTKEEMSFRTYTARQRLNRLRRAACKLFTSEAMVKAIQRLELEVEAKRLLVRKDRHLWKDIGERQKVLNWLISYNPLWLRIGLETIYGELISLESNNDVMGLAMFILGRLLWNPDLAAEFRHSKVPHLYRDGHEEALSRFTLKKLILLVCFLDKAKESRLIEHDPCLFCMDAEFKSSKDLLLAFSRDFLSGEGILSRHLSHLGLAVSHVQTPLDEFNFAVKKLAVDLKCGIRLVRVMELFTLDWTLSRKLRIPAISRLQKVHNVDLALQVLKNKGVDLRDEHGANIDSRDIVDGHREKTLNLLWKIIFAFQVEVLLDENQLKEEISFLRKTWRTKQKLASIMANNSVTVSRMKARRAFEHPSQKVTLLMDWVNAVCEFYSLKAENFTVSFSDGRILCYLIHHYHPGHLHAEEIQQRTTQTIECGHRGRVELNNSSSDSDCSFENLATMQSESVTVDFRELLENEKSNFQLVNTAVSYLGGVPAMINPEDMSNTIPNEKVVTCYLSFLCARLLDLRNETRAARVIQGAWRRYKLQKDIALMHEKNLAATKIQALARKFILKRRLIRQNKAAVKIQTLWRGYSAREKLRVLKKERHYALQNAAATLIQKTYKAWRVKNLLKKNRSAFVIQAAFRKWHAKKMLERNTAALRIQAWYRMQLCKRQYLEMKRKAVCVQAWFRGHLQRSKFQNLKKRHHASVVIQSAFRAYLIRKELSKMKQNAVLIQRWFRACVQRKAEQKRYFEIKSAVLVLQAAFRGWKVRKSVAQHHRSALVIQTAFRRFTAQRHFLCLKRSAIVLQQRYRAKVHGGKFRKEYMALKSASVRIQAMWRGRAERKKISQLHRFAKIIQSNYRRHLEQTRFLQMKRAAVVIQRQYRAFRDGQKVHAEYTKIKRAAIILQSAYRGRRIRQELQRKNKAATLIQSVMRAHMCHQQFLAQKHAAIVIQQQFRAFTFGRMERSHYMRLRKATITMQAIYRGSKVRQNLKREHQAATVIQAQFRMHKVRIPFVAAKCAAILIQQHYRAYKVGKTVQATYLQMKNAAVVIQSAFRGMKVRNYLRKSHQAAKVIQAHFRGHSQLKKYRRQQWAASVLQQRFRATVTKNAVMKQYAAIKTATICIQSAFRGMVARKQIAEKQKCAKIIQKMYRAYKQRHDYLALRNATIRIQQQYRAVVSARQQHQRYCSLRAAAITLQSSYRGLRARKEINRRQKAATVIQAAYKMYRTRVPFQAMKLASLVIQRQYRCHLLRKKARENFLKLKQSAVAIQAIYRGKLARRDLARRHFAATIIQRKYLAYKQRKCFLTLQAAVIFCQQHYRSILLTRHDRKDYLTKRRAVVAIQASFRGMNVRRQIRREHKAATIIQSHVRMRILNLRFQRLRWAVCTVQQRFRANKIMRQEMAALQEKKSAALILQAAYRGKKTRQALKQMHQAATIIQSHVRMRILNLRFQRLRWAVCTVQERFRANRIMRQEMAALQEKKSAALILQAAYRGKKTRQALKQMHQAATIIQSHVRMRILNLRFQRLRWAVCTLQRHFRANKIMRQEMAALQEKKSAALILQAAYRGMKTRHTLKQMHQAATIIQSHVRMRILNLRFQRLRWAVCTVQQRFRANRIMRQEMAALQEKKSAALILQAAYRGMKTRQTLKQMHQAATIVQATYRAYSGRKRYLEMKCAAIDIQQRYRAVNAAKQQRKSYLKVRQGALVLQACYRGRKVRRNLQLQCQAAVLIQSYFRRHKEMVKYQAMKLSAVIIQSHFRSYIQARADRKNYQHLRKSAIVIQAAFRGHSLRRHLARKQEASVIIQASFRMYQQRSAFKKQRWAARVLQQRFRALKLRDEHVCQYQQVRNAAVCLQRYFRGMKGRELARRSKAARTIQSFLRMSVQRQRFMKEKAAAIAIQSAYRGHFARAQYTRMQAGTVLIQKWYRSRKLVQEDRKRFVAVRQATLTLQSALRGMLVRRLAKRRRAAIKIQSVMRMHIQRKRYVTLRASALKFQAHYRMLVAQRKYRRLQAATVTLQKHYRSHRATLEQRCSYLKTLQNIKKLQARVRGHIAYKRFQRLRTCAITIQANYRGMIERRRFHQLKECALVIQKHYRAFILCQKERSKFLQLRQSAVVIQRAYRAYQKRQNAMKAQAALKIQAWFRGRLARRNYILKQAASATIRRCIQARRQRSKFLAVQHSVRVIQQRWRETLSSRKQHAEFLKLIKSVIYIQALWRGRRLRDSIQKQATAAVKIQSAFRGSIQRRRYHQQRNAAITLQRHFRVLRLARVKEENLRRRHNAAIYIQALWRGWLARQQVKEMAFAARRLRFTAAVYHHLSAIKIQRAVRAHWALKSAKKKISSVLYIQQCFRAKLQRKKYLKDREDIIKTQRAVRSWLHRRNQAASIIQHAVRKLLFRRRKERLQRGIIRAQALWRGHCSRKLHDTNKVISMRQRLREVNQRVKEEDKLCNKTTTALTYLLGLQNYAFILAALKHLETATRLSPECCERLVESGATHTIFTLIRSCNRSVPSMEIITLSIQVLLNLSKYHRTIDAVYDVDNSVETLLDLLQIYREKAGDKVADKGGSIFTKTCFLLVLLVQDERRAMEIRRLPKVMDRIRSIYRLTLRKCKMDAERNKVKQKMNTSLNGSFLLQATPRKSKPVARFAPDWVLRRDKMKDIVDPLRAIQILANALAIVP", "length": 3411 }, "evidence": [ { "id": "A0AAA9SF96", "url": "https://omabrowser.org/oma/group/A0AAA9SF96/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZZQ1-1", "protein_name": "Assembly factor for spindle microtubules", "gene_name": "Aspm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATVQAAYSSEESGRRARRDPAAEDASPPVLLLSHFCAVPFLCFGDVRVGTSRTRSLVLHNPHAEPLHVELSLLRAAGQGFSASPNRCELQPKEKITISVTWTPLKEGGVREIVTFLVNDFLKHQAVLLGNAEEQRKKKRSLWNTSKKIPASSKYTKRTSKNQNFNESFTISQKVDRIRSPLQPCENLAMSECCSPTENSSLPLEENKVPTSSISPIRECQSEACLSLFSPGPTAYSSLHESENARNSKVQDASISKNFDFNEEVTNETFINPISVSHHSEGDSKLALTPNCSSPLNIAQTQMHFLSPDSFENDSYTSDNGLRSMKNVLSDTFKKDPSESVCLESQTVHEVCQTILSPESFLNDNYGLKKGLNLESVNPVLSPTQFVKDNMVHVGQQMGELSPLPAKPSQDRRVNEGLADNPKGQHAQTPSSKSEQQNPGEMNLHNYGFTKQKPKISELQDAFCNQSKQLKKRRPILSATVTKRKPTNAREKLPEINKPNAKRSLEGVVGECGKEVDKLKEKAFHSSLPVVEAVINKPPSYRNEVTPSTVVIARKRKSSGTVGDTSGKLAVAEWMDVCEIKRIHFSPLESTPSTVARTTKKEALTSNRISNLERSGLKKKTDSSILKTPLSKTKRKRRSIVPVAQSHLTFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNYILTPDDFTVKTNVSKVNAATLILGAEGQHKVSVPKAPTKEEVSLRAYTASCRLNRLRRTACSLFTSEKMVKAIKKIEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPLADNSDITGLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKISRLIDHDPCLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSLLGLPVSHVQTPLDEFDFAVTNLAVDLQCGVRLVRTIELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVSLTDEHGNTILSKDIVDRHREKTLGLLWKIAFAFQVDISLNLNQLKEEIDFLKHTHNIKTAMSALICSSPAVTKKQKDRRFSGNFEHYGDSVKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPGYVPFDAICQRTTQSVACTQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLGGIPAMIHHADMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQITWRKYKLKRDLKDRQERDKAARIIQAVVLNFLTRRRLQKRVSAALVIQTCWRRVSAQRKLLMLKNEKLAKLHSASASLIQAHWRRHSTRKHFLKLKHCSVILQSRLRMKIALTSYKRYRWATVTIQRRWRAHLSRKRDQQRFRKLKSASLVIQSVFRRWKRRKLQLQTKAAVTLQRAFREWRCRKQTRERAAVVIQSWYRMHRELQKYIYIRSCVVVIQRRVRCFHAQKLCKRRKDAVLTLQKHFRARQMGKLARTDYLQKRAAAIQLQAAFRGMKARRSYRLQIQAACVLQSYWRMRQGRVKFLNLKKTVIKLQAHIRKHQQLQKYQKIKKAAVTIQTHFRASISARKSLASYQKTRSSVIVLQSAYRGMQARKTFRRALTSVVKIQSCYRAYISRKKFRSLRNAAVKLQSIVKMKQSRKQYLQVRAAAVFIQRWYRSQKRKESVQVREACIKLQSYFRGCLVRKQMRLQSKAAISLQSYFRMWRVRQRYLKTRKAALVIQTFYSAYRAQVHQRKIFLQVKGAAVCLQAAYRGRRARRQIKQQSTAAVTIQRVFRGHSQRMKYQTVLQSAVKVQRWYRAHKVASDMRIHFLKTREAVVVLQSACRGWQVRQQLRRQHQAAVKIQAAFRMARAQRQYKLVRNAAVVIQQHVRARAAGERQHSEYIRLRHAALVFQATWKGKMLRREIAQRHQCAALIQSYYRMYSQRRKWSLMKTAARQIQVCYRAYRVGKEQRHLYLKTKAAVVILQSAYRGMKARRQITECHKAAVTIQSKFRAYRTQKKYTTCRTSAIIIQRWYRNIKITTQQREAYLTLKRAATKVQAVYRGIQVRRHIQHMYMAATLIKALFKIQQSRAAAVIQVRYRAYYLGKIQQEKYLTTLRAIKTLQAGVRGARVRKTLRKMHFAATLIQSYFRRHRQRTYFHRLRKAATVVQQRYRAVKEGSSQFQRYSRLRRSVILVQAAFRGLKARRHLKAMHLAATVIQRRFRTLLMRRKFLSLRKTVIWIQRQYRARLHAKYCRQQLLLEKAVTKIQSSYKGWMVRKSVQKMHRAATVIQATFRMHRACVRYQRLKRASVVIQKQYRAHRTAELQRQLFVRQRQAALTLQAAFRGVKARNHLKTMHASATLIQSKFRARIVRRQFLALRKAAIFVQRKYRATLYAKHKLHQFLQLRKAAITIQSSFRRLMVKKQLQERHRAAALIQATFRMHRTYVRFHLWKRASIRIQQHYRTYRTRKLQREQLSREEHRAAVRIQSTYRMHRQRCVYQQLRWAAKVIQKKYRANKRRQDLPMACKEETPLTQMHFQGSNMAKQVQLQHDAAVIIQKHFRAFKARRLVEAERGSQAVWRTSEARQDLRRGEAACRIQAWYRRCRVRRRYLTLLKAVKTIQGYFYAKQERTRFLKMRAAAIIIQRKWRAALCARAACESLTLKRHGAACVIQAHFRGYKGRQSFRQQRSAALTIQRYVRASVAARQERTKYVQFKKSAVVLQALVRGWLARKRVSEQKANIRRFRFIAAAYCHMCALRIQRAYRRHVAMRNAKKHVNSVIVIQRWFRRRLQQQRFIEQYRKIMAAERDVQARRHQQDRAASVIQKAVRRFLLSRRQQKVNSSATRIQALWRGYASRKKNDRTEIKAIRQSLRAVSRNVEEENKLYRRTERALHHLLTYKHLSAILEAMKHLEVVTRLSPLCCENMAESGAVSTVFVVIRSCNRSVPCMEVVGCAVQVLLNVAKYDKTISAVYDAENCVDTLLELLQAYREKPGDRVAEKSASIFTRTCCLLAVLLKTEQCAFDAQSRSKVIDRIYRLYKFTVPKHKVNTQGLFDKQKQNSCIGFPFIPERSIKTRIVSRLKPQWVLRRDNMEEITNSLQAIQLVMDTLGIPYC", "length": 3133 }, "evidence": [ { "id": "A0AAA9SF96", "url": "https://omabrowser.org/oma/group/A0AAA9SF96/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CJ27-1", "protein_name": "Abnormal spindle-like microcephaly-associated protein homolog", "gene_name": "Aspm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATMQAASCPEERGRRARPDPEAGDPSPPVLLLSHFCGVPFLCFGDVRVGTSRTRSLVLHNPHEEPLQVELSLLRAAGQGFSVAPNRCELKPKEKLTISVTWTPLREGGVREIVTFLVNDFLKHQAILLGNAEEPKKKKRSLWNTSKKIPASSKHTKRTSKNQHFNESFTISQKDRIRSPLQPCENLAMSECSSPTENKVPTPSISPIRECQSETCLPLFLRESTAYSSLHESENTQNLKVQDASISQTFDFNEEVANETFINPISVCHQSEGDRKLTLAPNCSSPLNSTQTQIHFLSPDSFVNNRYTSDNDLKSMKNVLSDTFRKDPAESVCLESQTVHEVCQTILSPDSFLNDNYGLKKGLNFKSVNPVLSPTQFVKDSMGHVGQQTGKSNEASQDWRINEGLAYTPECQHAQTPSSRSEKQNPVEVKPHTYDFTKQKPKISEFQDAFCHQSKQPHKRRPILSATVTKRKPTNAREKLPEINKPDAKRCLEGLVGERGKEVGSLREKGFHSSLPVVEPGVSKALSYRDEVTPATVVVARKRKSHGTVGDANGKVAAEEWMDMCEVKRIHFSPLESTPSTVARTTKKEGHTSKRISSLERSGLKKKMDSSILKTPLSKTKKKRRSIVAVAQSHLTFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNYILTPDDFTVKTNVSKVNAASLVLGAESQHKISVPKAPTKEEVSLRAYTASCRLNRLRRTACSLFTSEKMVKAIKKVEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPLADNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKISRLIDHDPCLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSFLGLPVSHVQTPLDEFDFAVTNLAVDLQCGVRLVRTVELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVPLTDEHGSAISSKDVVDRHREKTLGLLWKIALAFQVDISLNLDQLKEEIDFLKHTHSIKRAMSALTCPSQAITNKQRDKRISGNFERYGDSVQLLMDWVNAVCAFYNKKVENFTVSFSDGRILCYLIHHYHPCYVPFDAICQRTSQSVACAQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKRDLKHHQERDKAARVIQSVVLNFLSRRRLQKNVSAALVIQKCWRRVSAQRKLRMLKNEKLAKLQNKSAVLIQAYWRRYSTRKRFLRLKHYSVILQSRIRMKIALTSYKRYLWATVTIQRHWRAYLSRKRDQQIFRKLKSSSLVIQFMFRRWKRRKLQLQTKAAVTLQRAFREWHLRKQIRERSAVVIQSWYRMHRELQKYIYIRSCVIVIQRRVRCFQAQKLYKRRKDAILTLQKHYRARQKGKLAHADYLQKRAATIRLQAAFRGMKARHSYRLQIGAACVLQSYWRMRQERVRFLNLKKMVIKLQAHIRKYQQLQKYKKIKKAAITIQTHFRASISARRVLASYQKTRSSVIVLQSACRGMQARKAFRHALASVIKIQSYYRAYICRKTFQNFKNATIKLQSIVKMKQSRKQYLQIRAAALFIQRWYRSQKLASQKRKEYIQVRESCIKLQSHFRGCLVRKQLRLQCKAAISLQSYFRMRTARQRYLKMCKAALVIQSFYCAYRAQISQRKNFLQVKRAAICLQAAYRGCKVRRQIKQQSTAAVTIQRVFRGHSQRMKYQTMLQSAVKIQRWYRAQKVAYDMRIQFLKTREAVVCLQSAYRGWQVRQQLRRQHEAAVKIQSTFRMAVAQQQYKLLRAAAAVIQQHVRARAAGKRQHLAYIQLRHAALVFQAAWKGKMLRRQIARQHQCAALIQSYYRMHIQRRKWSIMKTAALQIQLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRGMKVRKRVAECHKAAVTIQSKFRAYRTQKKYTTYRTSAIVIQRWYRNIKITTQQHQEYLNLRRAAVQVQAAYRGIRVRRRIQHMHMAATLIEAMFKMRQSRVRYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRRTVRKMHFAATLIQSHFRGHRQQTYFHRLRKAATMVQQRYRAVKEGSAEFQRYSRLRRSVLLIQAAFRGLRTRRHLKAMHLAATLIQRRFRTFAMRRKFLSLRKTAIWIQRQYRARLYAKYSRQQLLLEKAVIKIQSSYRGWVVRKRVQKMHRAATVIQATFRMHGAYMRYQHLKRASVVIQVHTAAELQRQKHAAVILQAAVRGMKTRSHLKTMHSSATLIQSQFRAFIVRRRFIALRKAAIFVQRKFRATLYAKHKLHQFLQLRKAAITIQSSYRRLMVQKKLQEMHRAAALIQATFRMHRTYVAFHIWKCASIRIQQCYRTYRTIKLQKEKLIREEQHSAAVLIQSTYRMYRQRCFYQQRRWAAKVIQKTYRANKRRQDLLYVCKEETPLLQMHFQGLNTAKQGRQQHGAAMITQKHFRAFKARRLMEAERGFQAGCRKYKAKKYLSKVEAACRIQAWYRRWRAHKKYLTLLKAVNIIEGYLSAQLARRRFLKMRAAAIIIQRKWRATLSVRGARENLKRHRAACVIQAHFRGYQARQSFLQQRSAVLIIQRHVRAMVAAKQERIKYIKLKKSTVVVQALVRGWLVRKRVSEQKAKTRLFHFTAAAYCHMCALKIQRAYRLHVTLRNAKKHMDSVIFIQRWFRKRLQRKRFIEQYHKILSTRREAHACWLQQDRAASVIQKAVRRFLLCRRQEKITSCATRIQALWRGYSWRKKNDHTEIKAIRRSLRAVSTTVEEENKLYRRTERALHHLLTYKHLSAILDALKHLEVVTRLSPLCCENMAESGAVSTIFVVIRSCNRSVPCMEVVGYAVQVLLNVAKYDKTIAAVYEAENCVDTLLELLQVYREKPGDRVAEKSASIFTRTCCLLAVLLKTEQCAFDAQSRSKVTDRIYRLYKFTVPKHKVNTQGLFDKQKQNSCVGFPCIPERTMKTRLVSRLKPQWVLRRDNVEEITNSLQAIQLVMDTLGISY", "length": 3122 }, "evidence": [ { "id": "A0AAA9SF96", "url": "https://omabrowser.org/oma/group/A0AAA9SF96/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZT6-1", "protein_name": "Abnormal spindle-like microcephaly-associated protein", "gene_name": "ASPM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQRGENSKLSLTPNCSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSQPVHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDANVRVAITEHTEVREIKRIHFSPSEPKTSAVKKTKNVTTPISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQRAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRCFQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHAVLVLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRCRAYYQGKMQREKYLTILKAVKVLQASFRGVRVRRTLRKMQTAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYWAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQSTFRMHRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLYQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMYRTYITFQTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARQLLREKHKASIVIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKVFQHNELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYRMHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFRGMKVRQKLKNVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVTIQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILPAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKHERIKYIEFKKSTVILQALVRGWLVRKRFLEQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY", "length": 3477 }, "evidence": [ { "id": "A0AAA9SF96", "url": "https://omabrowser.org/oma/group/A0AAA9SF96/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "microtubule minus-end", "id": "GO:0036449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036449", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "meiotic spindle", "id": "GO:0072687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072687", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "spindle organization", "id": "GO:0007051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "spindle localization", "id": "GO:0051653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051653", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" }, { "name": "regulation of meiotic cell cycle", "id": "GO:0051445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051445", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SF96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1133, "end_pos": 1135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1180, "end_pos": 1182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1201, "end_pos": 1203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1639, "end_pos": 1641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1722, "end_pos": 1724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1839, "end_pos": 1841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 667, "end_pos": 669, "annotation": "n_glycosylation_sequon" }, { "start_pos": 721, "end_pos": 723, "annotation": "n_glycosylation_sequon" }, { "start_pos": 726, "end_pos": 728, "annotation": "n_glycosylation_sequon" }, { "start_pos": 990, "end_pos": 992, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SF96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF96" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 920, "end_pos": 1056, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1133, "end_pos": 1135 }, { "start_pos": 1180, "end_pos": 1182 }, { "start_pos": 1201, "end_pos": 1203 }, { "start_pos": 1639, "end_pos": 1641 }, { "start_pos": 1722, "end_pos": 1724 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 1839, "end_pos": 1841 }, { "start_pos": 202, "end_pos": 204 }, { "start_pos": 302, "end_pos": 304 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 667, "end_pos": 669 }, { "start_pos": 721, "end_pos": 723 }, { "start_pos": 726, "end_pos": 728 }, { "start_pos": 990, "end_pos": 992 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "exact_o_linked_glycan_sites", "count": 3 }, { "field": "exact_o_linked_glycans", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "exact_o_linked_glycan_sites", "count": 3 }, { "field": "exact_o_linked_glycans", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 45 }, { "field": "total_sites", "count": 45 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1358 }, { "field": "total_sites", "count": 1117 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1315 }, { "field": "total_sites", "count": 1083 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 43 }, { "field": "total_sites", "count": 41 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 122 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SGE7-1", "uniprot_ac": "A0AAA9SGE7", "uniprot_id": "A0AAA9SGE7_BOVIN", "mass": { "chemical_mass": 16328.0, "monoisotopic_mass": 16328.0 }, "refseq": {}, "gene_names": [ { "name": "RANGRF", "type": "recommended", "evidence": [ { "id": "A0AAA9SGE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ] } ], "protein_names": [ { "name": "Ran guanine nucleotide release factor", "type": "recommended", "evidence": [ { "id": "A0AAA9SGE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7/entry#names_and_taxonomy" } ] }, { "name": "Ran-binding protein MOG1", "type": "synonym", "evidence": [ { "id": "A0AAA9SGE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.", "evidence": [ { "database": "UniProtKB", "id": "F1MW14", "url": "https://www.uniprot.org/uniprotkb/F1MW14#function" }, { "database": "UniProtKB", "id": "ARBA00059721", "url": "https://www.uniprot.org/uniprotkb/ARBA00059721#function" }, { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RANGRF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7", "locus": { "chromosome": "19", "start_pos": 27905330, "end_pos": 27903909, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018809", "url": "https://www.ensembl.org/id/ENSBTAG00000018809" } ] } } ], "crossref": [ { "id": "A0AAA9SGE7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018809", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018809", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ECSSAWM", "url": "https://omabrowser.org/oma/group/ECSSAWM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MW14", "url": "https://www.orthodb.org/?gene=F1MW14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15837:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15837:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5576892", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576892", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW14", "url": "https://www.uniprot.org/uniprotkb/F1MW14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW14-1", "url": "https://www.uniprot.org/uniprotkb/F1MW14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPTRDYPLFGGAFSATLPPGAIDVSDLRPVPDHQEVFCHRVTDQSLIVELLELQAHVQGEEAARYHFEDVGGVQEARAVQVETVQPLVLENLALRGCCQEAWILSGQQQVAKENQQVAKYVTLHQALLRLPQYQTDLLLTFNQPP", "length": 146, "header": "tr|A0AAA9SGE7-1|A0AAA9SGE7_BOVIN Isoform 1 of Ran guanine nucleotide release factor OS=Bos taurus OX=9913 GN=RANGRF PE=3 SV=1 CANONICAL=A0AAA9SGE7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7/entry#A0AAA9SGE7-1", "sequence": { "sequence": "MEPTRDYPLFGGAFSATLPPGAIDVSDLRPVPDHQEVFCHRVTDQSLIVELLELQAHVQGEEAARYHFEDVGGVQEARAVQVETVQPLVLENLALRGCCQEAWILSGQQQVAKENQQVAKYVTLHQALLRLPQYQTDLLLTFNQPP", "length": 146, "header": "tr|A0AAA9SGE7-1|A0AAA9SGE7_BOVIN Isoform 1 of Ran guanine nucleotide release factor OS=Bos taurus OX=9913 GN=RANGRF PE=3 SV=1 CANONICAL=A0AAA9SGE7-1" }, "locus": { "chromosome": "19", "start_pos": 27904849, "end_pos": 27904028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098036.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098036.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081567.1" } ] } }, { "isoform_ac": "F1MW14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7/entry#F1MW14-1", "sequence": { "sequence": "MEPTRDYPLFGGAFSATLPPGAIDVSDLRPVPDHQEVFCHRVTDQSLIVELLELQAHVQGEEAARYHFEDVGGVQEARAVQVETVQPLVLENLALRGCCQEAWILSGQQQVAKENQQVAKYVTLHQALLRLPQYQTDLLLTFNQPPPENRSSLGPENLSIPPWSLGDFEQLVTSLTLHDPNIFGPQ", "length": 186, "header": "tr|F1MW14-1|F1MW14_BOVIN Computationally mapped isoform of Ran guanine nucleotide release factor OS=Bos taurus OX=9913 GN=RANGRF PE=3 SV=1 CANONICAL=A0AAA9SGE7-1" }, "locus": { "chromosome": "19", "start_pos": 27905172, "end_pos": 27904028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025038.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025038.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025038.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025038.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5576892", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576892", "resource": "Reactome", "description": "Phase 0 - rapid depolarisation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AY47-1", "protein_name": "Ran guanine nucleotide release factor", "gene_name": "RANGRF", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPMRDYPLFGGAFSATLPPGAIDVSDLRPVPDNQEVFCHRETDQSLIVELLELQAHVQGEEAARYHFEDVGGVQEARAVQVEAVQPLLLENLALRGCCQEAWILSGKQQVAKENQQVAKCVTLHQALLRLPQYQTDLLLTFNQPPSSLGPENLSLPPWSLGDFEQLVTSLTLHDPNIFGSQ", "length": 182 }, "evidence": [ { "id": "A0AAA9SGE7", "url": "https://omabrowser.org/oma/group/A0AAA9SGE7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A3KPP3-1", "protein_name": "Ran guanine nucleotide release factor", "gene_name": "rangrf", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSRPLFGGALSAVFPSSVMDISELRQIPDNQEVFAHSQTDQSIIIELLEYQSQVQDADAARYHFEDVAGSNKAIENGTWEVRVVEQVPQSEISMQECSSAWLLSGAQLVSKFNEEAKNTVNVHQCLFRLPQFTTDILMTFNDPVFINPLSSSAAGNMEAIPWTLQDFQGVLQSLRLLDSGVFG", "length": 183 }, "evidence": [ { "id": "A0AAA9SGE7", "url": "https://omabrowser.org/oma/group/A0AAA9SGE7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZMP9-1", "protein_name": "Ran guanine nucleotide release factor", "gene_name": "Rangrf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPARNCPLFGGAFSAILPRGAIDVSDLRPVPDNQEVFCHPVTDQSLIIELLELQAHVQGEAAARYHFEDVGGVQGARSVHVLSVQPLCLENLSLRGCCQDAWFLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRPLGPENLSCPPWSLGNFEQLVTSLTLHDPNLFGPQ", "length": 185 }, "evidence": [ { "id": "A0AAA9SGE7", "url": "https://omabrowser.org/oma/group/A0AAA9SGE7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47123-1", "protein_name": "Nuclear import protein MOG1", "gene_name": "MOG1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKIEKASHISQPVQLSTCTLIDTYPGHQGSMNNKEVELYGGAITTVVPPGFIDASTLREVPDTQEVYVNSRRDEEEFEDGLATNESIIVDLLETVDKSDLKEAWQFHVEDLTELNGTTKWEALQEDTVQQGTKFTGLVMEVANKWGKPDLAQTVVIGVALIRLTQFDTDVVISINVPLTKEEASQASNKELPARCHAVYQLLQEMVRKFHVVDTSLFA", "length": 218 }, "evidence": [ { "id": "A0AAA9SGE7", "url": "https://omabrowser.org/oma/group/A0AAA9SGE7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9HD47-1", "protein_name": "Ran guanine nucleotide release factor", "gene_name": "RANGRF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ", "length": 186 }, "evidence": [ { "id": "A0AAA9SGE7", "url": "https://omabrowser.org/oma/group/A0AAA9SGE7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JIB0-1", "protein_name": "Ran guanine nucleotide release factor", "gene_name": "Rangrf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPNRNCPLFGGAFSAILPTGAIDVSDLRPVPDNQEVFCHPVTDQSLIIELLELQAHVQGEAAARYHFEDVGRVQGARAVHVLSVQPLCLENLSLRGCCQDAWSLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRSLGPENLSCPPWSLSNFEQLVTSLTLHDPNLFGPQ", "length": 185 }, "evidence": [ { "id": "A0AAA9SGE7", "url": "https://omabrowser.org/oma/group/A0AAA9SGE7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "regulation of membrane depolarization", "id": "GO:0003254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003254", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "regulation of sodium ion transmembrane transport", "id": "GO:1902305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902305", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "regulation of membrane depolarization during cardiac muscle cell action potential", "id": "GO:1900825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900825", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "mitotic spindle assembly", "id": "GO:0090307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "positive regulation of protein localization to cell surface", "id": "GO:2000010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "heart contraction", "id": "GO:0060047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "positive regulation of protein localization to plasma membrane", "id": "GO:1903078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903078", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "regulation of cardiac muscle cell action potential involved in regulation of contraction", "id": "GO:0098909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "positive regulation of membrane depolarization during cardiac muscle cell action potential", "id": "GO:1900827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900827", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "regulation of bundle of His cell action potential", "id": "GO:0098905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "protein exit from endoplasmic reticulum", "id": "GO:0032527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "sodium channel regulator activity", "id": "GO:0017080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "channel activator activity", "id": "GO:0099103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099103", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "rough endoplasmic reticulum", "id": "GO:0005791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "intercalated disc", "id": "GO:0014704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014704", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" }, { "name": "caveola", "id": "GO:0005901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI76-1", "uniprot_ac": "A0AAA9SI76", "uniprot_id": "A0AAA9SI76_BOVIN", "mass": { "chemical_mass": 17088.0, "monoisotopic_mass": 17088.0 }, "refseq": {}, "gene_names": [ { "name": "PTP4A1", "type": "recommended", "evidence": [ { "id": "A0AAA9SI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ] } ], "protein_names": [ { "name": "Protein tyrosine phosphatase 4A1", "type": "synonym", "evidence": [ { "id": "A0AAA9SI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTP4A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76", "locus": { "chromosome": "9", "start_pos": 458072, "end_pos": 453116, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002275", "url": "https://www.ensembl.org/id/ENSBTAG00000002275" } ] } } ], "crossref": [ { "id": "A0AAA9SI76", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002275", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002275", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18537", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18537", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613326", "url": "https://www.ncbi.nlm.nih.gov/gene/613326", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613326", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613326", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IQVHGWT", "url": "https://omabrowser.org/oma/group/IQVHGWT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G5E526", "url": "https://www.orthodb.org/?gene=G5E526", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22785", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22785", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E526", "url": "https://www.uniprot.org/uniprotkb/G5E526", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E526-1", "url": "https://www.uniprot.org/uniprotkb/G5E526-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARMNRPAPVEVTYRNMRFLITHNPTNATLSKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREDPGCCIAVHCVAGLGRKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 148, "header": "tr|A0AAA9SI76-1|A0AAA9SI76_BOVIN Isoform 1 of Protein tyrosine phosphatase 4A1 OS=Bos taurus OX=9913 GN=PTP4A1 PE=4 SV=1 CANONICAL=A0AAA9SI76-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76/entry#A0AAA9SI76-1", "sequence": { "sequence": "MARMNRPAPVEVTYRNMRFLITHNPTNATLSKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREDPGCCIAVHCVAGLGRKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 148, "header": "tr|A0AAA9SI76-1|A0AAA9SI76_BOVIN Isoform 1 of Protein tyrosine phosphatase 4A1 OS=Bos taurus OX=9913 GN=PTP4A1 PE=4 SV=1 CANONICAL=A0AAA9SI76-1" }, "locus": { "chromosome": "9", "start_pos": 456813, "end_pos": 453248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090457.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090457.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082249.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082249.1" } ] } }, { "isoform_ac": "G5E526-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76/entry#G5E526-1", "sequence": { "sequence": "MARMNRPAPVEVTYRNMRFLITHNPTNATLSKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREDPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 173, "header": "tr|G5E526-1|G5E526_BOVIN Computationally mapped isoform of Protein tyrosine phosphatase 4A1 OS=Bos taurus OX=9913 GN=PTP4A1 PE=3 SV=1 CANONICAL=A0AAA9SI76-1" }, "locus": { "chromosome": "9", "start_pos": 456813, "end_pos": 453248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002933.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002933.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002933.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002933.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613326", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613326", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N686-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "Ptp4a1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIRVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 173 }, "evidence": [ { "id": "A0AAA9SI76", "url": "https://omabrowser.org/oma/group/A0AAA9SI76/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O61722-1", "protein_name": "PRL-1 phosphatase", "gene_name": "PRL-1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSITMRQKDLRPAPALIEYKGMKFLITDRPSDITINHYIMELKKNNVNTVVRVCEPSYNTDELETQGITVKDLAFEDGTFPPQQVVDEWFEVLKDKYQQNPEACVAVHCVAGLGRAPVLVALALIELGLKYEAAVEMIRDKRRGAINAKQLSFLEKYKPKARLKHKNGHKNSCSVQ", "length": 176 }, "evidence": [ { "id": "A0AAA9SI76", "url": "https://omabrowser.org/oma/group/A0AAA9SI76/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q54DU9-1", "protein_name": "Probable protein tyrosine phosphatase type IVA A", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTGIRSALPNPASLVESSTHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALIEGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSKKKSSCRIM", "length": 166 }, "evidence": [ { "id": "A0AAA9SI76", "url": "https://omabrowser.org/oma/group/A0AAA9SI76/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q63739-1", "protein_name": "Protein tyrosine phosphatase type IVA 1", "gene_name": "Ptp4a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 173 }, "evidence": [ { "id": "A0AAA9SI76", "url": "https://omabrowser.org/oma/group/A0AAA9SI76/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q78EG7-1", "protein_name": "Protein tyrosine phosphatase type IVA 1", "gene_name": "Ptp4a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 173 }, "evidence": [ { "id": "A0AAA9SI76", "url": "https://omabrowser.org/oma/group/A0AAA9SI76/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q93096-1", "protein_name": "Protein tyrosine phosphatase type IVA 1", "gene_name": "PTP4A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ", "length": 173 }, "evidence": [ { "id": "A0AAA9SI76", "url": "https://omabrowser.org/oma/group/A0AAA9SI76/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SI76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI76" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 110, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 27, "end_pos": 29 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGS8-1", "uniprot_ac": "A0AAA9SGS8", "uniprot_id": "A0AAA9SGS8_BOVIN", "mass": { "chemical_mass": 39301.0, "monoisotopic_mass": 39301.0 }, "refseq": { "ac": "XP_005208528", "name": "ceramide synthase 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208528" }, "gene_names": [ { "name": "CERS1", "type": "recommended", "evidence": [ { "id": "A0AAA9SGS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8" } ] }, { "name": "CERS1", "type": "synonym", "evidence": [ { "id": "XP_005208528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208528" } ] }, { "name": "LASS1", "type": "synonym", "evidence": [ { "id": "XP_005208528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208528" } ] } ], "protein_names": [ { "name": "Ceramide synthase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SGS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8/entry#names_and_taxonomy" } ] }, { "name": "ceramide synthase 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005208528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208528" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CERS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8", "locus": { "chromosome": "7", "start_pos": 4333137, "end_pos": 4313650, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037729", "url": "https://www.ensembl.org/id/ENSBTAG00000037729" } ] } } ], "crossref": [ { "id": "A0AAA9SGS8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "615296", "url": "https://www.ncbi.nlm.nih.gov/gene/615296", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12560", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12560", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12560:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12560:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208528", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208528", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36547", "url": "https://www.rhea-db.org/rhea/36547", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAGSAGPEPMPSYAQLVQRGWGSALAAARGCADCGWGLARRGLAEHAHLAPPELLLLALGALGWTVLRSAATSRLFRPLAKRCRLQPRDAAKMPESAWKFLFYLGAWSYSTYLLFGTDYPFFHDPPSVFYDWKTGMAVPRDIAVAYLLQGSFYGHSIYATLYLDAWRKDSVVMLVHHVVTLVLIVSSYAFRYHKVGILVLFLHDISDVQLEFTKLNVYFKSRGGAHHRLHALAADLGCLSFCLSWFWFRLYWFPLKVLYATSYCSLRSVPDIPFYFFFNVLLLLLTLMNLYWFLYIVAFAAKVLTGQVRELKDVREYDTAEAPSPKPRKAEKPLRNGLVKDKRF", "length": 346, "header": "tr|A0AAA9SGS8-1|A0AAA9SGS8_BOVIN Isoform 1 of Ceramide synthase 1 OS=Bos taurus OX=9913 GN=CERS1 PE=3 SV=1 CANONICAL=A0AAA9SGS8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8/entry#A0AAA9SGS8-1", "sequence": { "sequence": "MAAAGSAGPEPMPSYAQLVQRGWGSALAAARGCADCGWGLARRGLAEHAHLAPPELLLLALGALGWTVLRSAATSRLFRPLAKRCRLQPRDAAKMPESAWKFLFYLGAWSYSTYLLFGTDYPFFHDPPSVFYDWKTGMAVPRDIAVAYLLQGSFYGHSIYATLYLDAWRKDSVVMLVHHVVTLVLIVSSYAFRYHKVGILVLFLHDISDVQLEFTKLNVYFKSRGGAHHRLHALAADLGCLSFCLSWFWFRLYWFPLKVLYATSYCSLRSVPDIPFYFFFNVLLLLLTLMNLYWFLYIVAFAAKVLTGQVRELKDVREYDTAEAPSPKPRKAEKPLRNGLVKDKRF", "length": 346, "header": "tr|A0AAA9SGS8-1|A0AAA9SGS8_BOVIN Isoform 1 of Ceramide synthase 1 OS=Bos taurus OX=9913 GN=CERS1 PE=3 SV=1 CANONICAL=A0AAA9SGS8-1" }, "locus": { "chromosome": "7", "start_pos": 4332735, "end_pos": 4313679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114254.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114254.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083089.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083089.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ceramide biosynthetic process", "id": "GO:0046513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sphingosine N-acyltransferase activity", "id": "GO:0050291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050291", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36547", "name": "", "equation": "sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BP45-1", "A0A3Q1MVP2-1", "Q3ZBF8-1", "A0AAA9TDQ3-1", "Q5E9R6-1" ], "evidence": [ { "id": "36547", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36547" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MVP2", "gene_name": "CERS5", "activity": [ { "ec_number": "2.3.1.24", "activity": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MVP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVP2" } ] }, { "ec_number": "2.3.1.24", "activity": "", "evidence": [ { "id": "A0A3Q1MVP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVP2" } ] } ] }, { "uniprot_ac": "A0AAA9TDQ3", "gene_name": "CERS3", "activity": [ { "ec_number": "2.3.1.24", "activity": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+).", "evidence": [ { "id": "A0AAA9TDQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ3" } ] }, { "ec_number": "2.3.1.24", "activity": "", "evidence": [ { "id": "A0AAA9TDQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDQ3" } ] } ] }, { "uniprot_ac": "E1BP45", "gene_name": "CERS6", "activity": [ { "ec_number": "2.3.1.24", "activity": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+).", "evidence": [ { "id": "E1BP45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ] }, { "ec_number": "2.3.1.24", "activity": "", "evidence": [ { "id": "E1BP45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ] } ] }, { "uniprot_ac": "Q3ZBF8", "gene_name": "CERS2", "activity": [ { "ec_number": "2.3.1.24", "activity": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+).", "evidence": [ { "id": "Q3ZBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF8" } ] }, { "ec_number": "2.3.1.297", "activity": "a very long-chain fatty acyl-CoA + a sphingoid base = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+).", "evidence": [ { "id": "Q3ZBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF8" } ] }, { "ec_number": "2.3.1.24", "activity": "", "evidence": [ { "id": "Q3ZBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF8" } ] } ] }, { "uniprot_ac": "Q5E9R6", "gene_name": "CERS4", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q5E9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R6" } ] }, { "ec_number": "2.3.1.24", "activity": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+).", "evidence": [ { "id": "Q5E9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R6" } ] }, { "ec_number": "2.3.1.24", "activity": "", "evidence": [ { "id": "Q5E9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SGS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS8" }, { "id": "PS50922", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50922" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TLC", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 307, "start_aa": "Ala", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGY5-1", "uniprot_ac": "A0AAA9SGY5", "uniprot_id": "A0AAA9SGY5_BOVIN", "mass": { "chemical_mass": 41368.0, "monoisotopic_mass": 41368.0 }, "refseq": {}, "gene_names": [ { "name": "SUPT3H", "type": "recommended", "evidence": [ { "id": "A0AAA9SGY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ] } ], "protein_names": [ { "name": "SPT3 homolog, SAGA and STAGA complex component", "type": "synonym", "evidence": [ { "id": "A0AAA9SGY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SUPT3H", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5", "locus": { "chromosome": "23", "start_pos": 18239634, "end_pos": 18641842, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032887", "url": "https://www.ensembl.org/id/ENSBTAG00000032887" } ] } } ], "crossref": [ { "id": "A0AAA9SGY5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032887", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032887", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07978", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07978", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LP47", "url": "https://www.orthodb.org/?gene=A0A3Q1LP47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAP1", "url": "https://www.orthodb.org/?gene=A0A3Q1MAP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIA7", "url": "https://www.orthodb.org/?gene=A0A3Q1MIA7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11380:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11380:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02269", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02269", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LP47", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP47-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAP1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIA7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIA7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0R3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLY3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNTAASPMSAATSSSGRSTGKSISFTAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAEGSCMKPYPESPENTPPPTPTAPSAGSQHSGKTTSGSLGNGSAGQDSAKTKQRKRKKSTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTCWPSSPGGEKLPSR", "length": 374, "header": "tr|A0AAA9SGY5-1|A0AAA9SGY5_BOVIN Isoform 1 of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=1 CANONICAL=A0AAA9SGY5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0A3Q1LP47-1", "sequence": { "sequence": "LQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTNAFLAFFVFIGYC", "length": 255, "header": "tr|A0A3Q1LP47-1|A0AAA9SGY5_BOVIN Computationally mapped isoform of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=3 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18376200, "end_pos": 18315028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085523.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085523.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058665.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058665.3" } ] } }, { "isoform_ac": "A0A3Q1MAP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0A3Q1MAP1-1", "sequence": { "sequence": "MNNTAASPMSAATSSSGRSTGKSISFTAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAEGSCMKPYPESPENTPPPTPTAPSAGSQHSGKTTSGSLGNGSAGQDSAKTKQRKRKKSTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTKTPAKNNSAGCVIYHEKDGQTCVSSRPRLCTSSGWCPWLPPLKRSPMLSEKCW", "length": 413, "header": "tr|A0A3Q1MAP1-1|A0A3Q1MAP1_BOVIN Computationally mapped isoform of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=2 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18628543, "end_pos": 18310371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071108.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071108.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071101.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071101.2" } ] } }, { "isoform_ac": "A0A3Q1MIA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0A3Q1MIA7-1", "sequence": { "sequence": "MNNTAASPMSAATSSSGRSTGKSISFTAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTISSSLTECLPQERDGFSGLLM", "length": 325, "header": "tr|A0A3Q1MIA7-1|A0AAA9SGY5_BOVIN Computationally mapped isoform of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=2 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18628543, "end_pos": 18239725, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083911.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083911.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074033.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074033.2" } ] } }, { "isoform_ac": "A0AAA9SE07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0AAA9SE07-1", "sequence": { "sequence": "MIMKTRFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAEGSCMKPYPESPENTPPPTPTAPSAGSQHSGKTTSGSLGNGSAGQDSAKTKQRKRKKSTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTSAYRRNGMAFLAC", "length": 345, "header": "tr|A0AAA9SE07-1|A0AAA9SGY5_BOVIN Computationally mapped isoform of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=1 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18492583, "end_pos": 18239730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127791.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127791.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082052.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082052.1" } ] } }, { "isoform_ac": "A0AAA9SGY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0AAA9SGY5-1", "sequence": { "sequence": "MNNTAASPMSAATSSSGRSTGKSISFTAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAEGSCMKPYPESPENTPPPTPTAPSAGSQHSGKTTSGSLGNGSAGQDSAKTKQRKRKKSTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTCWPSSPGGEKLPSR", "length": 374, "header": "tr|A0AAA9SGY5-1|A0AAA9SGY5_BOVIN Isoform 1 of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=1 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18628543, "end_pos": 18273822, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097229.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097229.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084592.1" } ] } }, { "isoform_ac": "A0AAA9U0R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0AAA9U0R3-1", "sequence": { "sequence": "MNNTAASPMSAATSSSGRSTGKSISFTAELQSMMFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAEGSCMKPYPESPENTPPPTPTAPSAGSQHSGKTTSGSLGNGSAGQDSAKTKQRKRKKSTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTKSSLSDDSDASQWRRTMLSSSSPCTPCSPTRPSVRS", "length": 396, "header": "tr|A0AAA9U0R3-1|A0AAA9U0R3_BOVIN Computationally mapped isoform of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=1 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18628543, "end_pos": 18303037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112082.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112082.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103254.1" } ] } }, { "isoform_ac": "A0AAF6DLY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5/entry#A0AAF6DLY3-1", "sequence": { "sequence": "MPLFLLRFSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVISAEDLLFLMRKDKKKLRRLLKYMFFRDYKSKIVKGIDEDDLLEDKLSGSNNVNKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRVMDSAQYAEFCESRHLSFSKKGSKFRDWLDCGSMEIKPNVIAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAEGSCMKPYPESPENTPPPTPTAPSAGSQHSGKTTSGSLGNGSAGQDSAKTKQRKRKKSTAACGVEAHSDAIQPSHIREAIRRYGHKIGPLSPFTSAYRRNGMAFLAC", "length": 346, "header": "tr|A0AAF6DLY3-1|A0AAF6DLY3_BOVIN Computationally mapped isoform of SPT3 homolog, SAGA and STAGA complex component OS=Bos taurus OX=9913 GN=SUPT3H PE=3 SV=1 CANONICAL=A0AAA9SGY5-1" }, "locus": { "chromosome": "23", "start_pos": 18492347, "end_pos": 18239730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046690.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046690.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043962.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043962.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 285, "start_aa": "Thr", "end_pos": 285, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr285", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 287, "start_aa": "Thr", "end_pos": 287, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr287", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" }, { "name": "transcription factor TFTC complex", "id": "GO:0033276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" }, { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 285, 287 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 2, "end_pos": 4 }, { "start_pos": 306, "end_pos": 308 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI25-1", "uniprot_ac": "A0AAA9SI25", "uniprot_id": "A0AAA9SI25_BOVIN", "mass": { "chemical_mass": 91241.0, "monoisotopic_mass": 91241.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "DnaJ homolog subfamily C member 10", "type": "recommended", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25/entry#names_and_taxonomy" } ] }, { "name": "1.8.4.-", "type": "synonym", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Endoplasmic reticulum disulfide reductase that collaborates directly with a BIP/HSPA5 (GRP78)-type chaperone to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25#function" }, { "database": "UniProtKB", "id": "PIRNR037293", "url": "https://www.uniprot.org/uniprotkb/PIRNR037293#function" } ] }, { "annotation": "Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25#function" }, { "database": "UniProtKB", "id": "ARBA00094198", "url": "https://www.uniprot.org/uniprotkb/ARBA00094198#function" }, { "database": "UniProtKB", "id": "A0A3Q1MIT7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIT7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25", "locus": {} } ], "crossref": [ { "id": "A0AAA9SI25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039671", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039671", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03003", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03003", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03004", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03004", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035673", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035673", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PRVEVFM", "url": "https://omabrowser.org/oma/group/PRVEVFM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR44340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44340:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44340:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "21064", "url": "https://www.rhea-db.org/rhea/21064", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MIT7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKVVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLDGLVNVGWVDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKSGILFLNSLDAKEIYLEIMHNLPDFELLSANSLQDRLAHHRWLLFFQFGQNENSNDPELKKLKTLLKNEHIQIGKFDCSSAPDVCSNFYVFQPCLAVFKGQGTKEFEIHHGKKILYDILALAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCRALLPELRKASKHLYGQLKFGTLDCTIHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQILMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRLYPYERAKRNTWGEQIDSRDAKEIATLIYEKLEKLQNHEKRDKDEL", "length": 793, "header": "tr|A0AAA9SI25-1|A0AAA9SI25_BOVIN Isoform 1 of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SI25-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25/entry#A0A3Q1MIT7-1", "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKVVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLDGLVNVGWVDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKSGILFLNSLDAKEIYLEIMHNLPDFELLSANSLQDRLAHHRWLLFFQFGQNENSNDPELKKLKTLLKNEHIQIGKFDCSSAPDVCSNFYVFQPCLAVFKGQGTKEFEIHHGKKILYDILALAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCRALLPELRKASKHLYGQLKFGTLDCTIHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQILMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRFSKIMRKEIRTNFNDVENEEKIEKKSTDDIRRYLFRKLLIFLMGINEPYLGLTVALPESVQH", "length": 809, "header": "tr|A0A3Q1MIT7-1|A0A3Q1MIT7_BOVIN Computationally mapped isoform of Endoplasmic reticulum disulfide reductase DNAJC10 OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SI25-1" }, "locus": { "chromosome": "26", "start_pos": 36959175, "end_pos": 36956649, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054050.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054050.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074241.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074241.2" } ] } }, { "isoform_ac": "A0AAA9SI25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25/entry#A0AAA9SI25-1", "sequence": { "sequence": "MGVWLNKDDYVRDLKRVMLFFLVMYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHSDFLKVNRAYEVLKDEDLRKKYDKYGEKGLADNQGGQYESWNYYRYDFGIYDDDPEIITLDRREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKVVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYHGDRSKESLMNFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSEGSDCLTSQTRLRLSGMLDGLVNVGWVDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKSGILFLNSLDAKEIYLEIMHNLPDFELLSANSLQDRLAHHRWLLFFQFGQNENSNDPELKKLKTLLKNEHIQIGKFDCSSAPDVCSNFYVFQPCLAVFKGQGTKEFEIHHGKKILYDILALAKESVNSHVTTLGPQNFPANEKEPWLVDFFAPWCPPCRALLPELRKASKHLYGQLKFGTLDCTIHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFVEDLMNPSVISLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQILMPEWKRMARTLIGLINVGSIDCQQYHSFCAQENVRRYPEIRFFPQKSNKAYEYHSYNGWNRDAYSLRIWGLGFLPQASIDLTPQTFNEKVLQGKNHWVVDFYAPWCGPCQNFAPEFELLARTLKGKVKAGKVDCQAYAQTCQKAGIRAYPTVRLYPYERAKRNTWGEQIDSRDAKEIATLIYEKLEKLQNHEKRDKDEL", "length": 793, "header": "tr|A0AAA9SI25-1|A0AAA9SI25_BOVIN Isoform 1 of DnaJ homolog subfamily C member 10 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SI25-1" }, "locus": { "chromosome": "26", "start_pos": 36960749, "end_pos": 36960313, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129852.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129852.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085883.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "IRE1-mediated unfolded protein response", "id": "GO:0036498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036498", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" }, { "name": "protein folding in endoplasmic reticulum", "id": "GO:0034975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" }, { "name": "protein-disulfide reductase activity", "id": "GO:0015035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015035", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" }, { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "id": "GO:0016671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016671", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21064", "name": "", "equation": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E936-1", "A0AAA9SI25-1", "F1N151-1" ], "evidence": [ { "id": "21064", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21064" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SI25", "gene_name": "", "activity": [ { "ec_number": "1.8.4.-", "activity": "", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] }, { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" } ] } ] }, { "uniprot_ac": "F1N151", "gene_name": "DNAJC10", "activity": [ { "ec_number": "1.8.4.-", "activity": "", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] }, { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "F1N151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N151" } ] } ] }, { "uniprot_ac": "Q5E936", "gene_name": "TXNDC12", "activity": [ { "ec_number": "1.8.4.2", "activity": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] }, { "ec_number": "1.8.4.2", "activity": "", "evidence": [ { "id": "Q5E936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E936" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 100, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SI25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI25" }, { "id": "PS51352", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51352" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 234, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.8.4.2", "ec_name": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide.", "evidence": [ { "id": "1.8.4.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.2" }, { "id": "1.8.4.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.8.4.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 530, "end_pos": 532 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SFA5-1", "uniprot_ac": "A0AAA9SFA5", "uniprot_id": "A0AAA9SFA5_BOVIN", "mass": { "chemical_mass": 87466.0, "monoisotopic_mass": 87466.0 }, "refseq": {}, "gene_names": [ { "name": "ARHGAP26", "type": "recommended", "evidence": [ { "id": "A0AAA9SFA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 26", "type": "recommended", "evidence": [ { "id": "A0AAA9SFA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#names_and_taxonomy" } ] }, { "name": "Rho-type GTPase-activating protein 26", "type": "synonym", "evidence": [ { "id": "A0AAA9SFA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5", "locus": { "chromosome": "7", "start_pos": 54280637, "end_pos": 53811371, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027151", "url": "https://www.ensembl.org/id/ENSBTAG00000027151" } ] } } ], "crossref": [ { "id": "A0AAA9SFA5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SFA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01249", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01249", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07636", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07636", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12064", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12064", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538219", "url": "https://www.ncbi.nlm.nih.gov/gene/538219", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538219", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538219", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AXIFNTV", "url": "https://omabrowser.org/oma/group/AXIFNTV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWV5", "url": "https://www.orthodb.org/?gene=A0A3Q1LWV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12552", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12552", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12552:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12552:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16746", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16746", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013406", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWV5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWV5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1B5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1B5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1B5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NNP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NNP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NNP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NNP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNB7", "url": "https://www.uniprot.org/uniprotkb/E1BNB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BNB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRPEEAVREDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 770, "header": "tr|A0AAA9SFA5-1|A0AAA9SFA5_BOVIN Isoform 1 of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=1 CANONICAL=A0AAA9SFA5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0A3Q1LWV5-1", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRSVAGFVCFFVAAVVLSSAWSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVREDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 815, "header": "tr|A0A3Q1LWV5-1|A0A3Q1LWV5_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=1 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54278744, "end_pos": 53811879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075058.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075058.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065196.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065196.1" } ] } }, { "isoform_ac": "A0A3Q1M1B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0A3Q1M1B5-1", "sequence": { "sequence": "MFVVHLGGTWGSAGEHCSGIQETVLSGCRSCLEAFPMQDSSDLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPISTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 750, "header": "tr|A0A3Q1M1B5-1|A0A3Q1M1B5_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=2 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54278744, "end_pos": 53848361, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071813.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071813.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061837.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061837.2" } ] } }, { "isoform_ac": "A0A3Q1NNP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0A3Q1NNP7-1", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLKNCSRQASLFMTHRISFPSTRAVCELGYLQPVGRGGMGGDGDQTPFSAQPASLTEWKSKKEQCFPSHGLFSSPLYKLKSWKGPAFSSIN", "length": 753, "header": "tr|A0A3Q1NNP7-1|A0AAA9SFA5_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=2 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54217310, "end_pos": 53811879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073051.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073051.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074522.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074522.2" } ] } }, { "isoform_ac": "A0AAA9SFA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0AAA9SFA5-1", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRPEEAVREDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 770, "header": "tr|A0AAA9SFA5-1|A0AAA9SFA5_BOVIN Isoform 1 of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=1 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54278744, "end_pos": 53811879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094118.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094118.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081132.1" } ] } }, { "isoform_ac": "A0AAA9SFX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0AAA9SFX9-1", "sequence": { "sequence": "MAVLALSQDLSLCHGWCPVAGSNAIWFVVVPMFLDLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPISTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 743, "header": "tr|A0AAA9SFX9-1|A0AAA9SFX9_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=1 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54278744, "end_pos": 53926059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116277.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116277.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084277.1" } ] } }, { "isoform_ac": "A0AAA9TP12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0AAA9TP12-1", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPISTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 736, "header": "tr|A0AAA9TP12-1|A0AAA9TP12_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=1 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54278744, "end_pos": 53811879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096042.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096042.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100111.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100111.1" } ] } }, { "isoform_ac": "A0AAA9TWN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#A0AAA9TWN1-1", "sequence": { "sequence": "IERAPPRGRCLPSGKDLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 687, "header": "tr|A0AAA9TWN1-1|A0AAA9TWN1_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=1 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54278744, "end_pos": 53812445, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111602.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111602.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102759.1" } ] } }, { "isoform_ac": "E1BNB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5/entry#E1BNB7-1", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFNDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETEMDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDAPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSLINSSLESVVSSNANSILNSSSSLQPNMNSSDPDLDVLKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRSVAGFVCFFVAAVVLSSAWSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVREDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNGVCTASQATSPVSSWSF", "length": 803, "header": "tr|E1BNB7-1|E1BNB7_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 26 OS=Bos taurus OX=9913 GN=ARHGAP26 PE=4 SV=4 CANONICAL=A0AAA9SFA5-1" }, "locus": { "chromosome": "7", "start_pos": 54271735, "end_pos": 53811879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060996.5", "url": "https://www.ensembl.org/id/ENSBTAT00000060996.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053583.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053583.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 671, "start_aa": "Thr", "end_pos": 671, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr671", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538219", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538219", "resource": "KEGG Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013406", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-BTA-9013409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013409", "resource": "Reactome", "description": "RHOJ GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AL79-1", "protein_name": "Rho GTPase-activating protein 26", "gene_name": "Arhgap26", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERSRMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETDICAEWEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDVPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHAVPSTEKQEQRNSIINSSLESVSSSANSILNSSSSLQPNMNFSDPSLDVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRPEEVVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 769 }, "evidence": [ { "id": "A0AAA9SFA5", "url": "https://omabrowser.org/oma/group/A0AAA9SFA5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZMW5-1", "protein_name": "Rho GTPase-activating protein 26", "gene_name": "ARHGAP26", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGLPALEFSECCLDSPQFRERLRSHEAELEKTNKFIKELIKDGKSLIAALKNLSSAKRKFADSLNEFKFRCIGDAETDDEICIAKSLQEFATVLRNLEDERMRMIENASEVLITPLEKFRKEQIGAAKDAKKKYDKETEKYCGVLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFSDFKTELTISIQNTRNRFEGTRSEVESLMKKMKENPHEHKNISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRESKRITMVPFDQKSGGKGGEDEAVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDNQSEGTAQLDSIGFSIIKKCIHAVETRGINEQGLYRIVGVNSRVQKLLSILMDPKTATETETEICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLHLLMNHLAKVADNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPETPPSNSQLLLSRKKSTDSKPPSCSERPLTLFHTAQPNEKQESRNSIINSSLESVISSNANSFLNSNSAPQSNLNSSDLELEVIKPNRPNSLPQNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPISSPLRKARALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 760 }, "evidence": [ { "id": "A0AAA9SFA5", "url": "https://omabrowser.org/oma/group/A0AAA9SFA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6ZQ82-1", "protein_name": "Rho GTPase-activating protein 26", "gene_name": "Arhgap26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFAAVLRNLEDERSRMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNRDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETDICAEWEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDVPLTNAQLHLSRKKSSDSKPPSCSKRPLTLFHAVPSTEKQEQRNSIINSSLESVSSSANSILNSSSSLQPNLNSSDSNLDVVKPSRPSSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRSVAGFVWFSVAAVVLSLAWSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVREDSSTPFRKAKALYACQAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 814 }, "evidence": [ { "id": "A0AAA9SFA5", "url": "https://omabrowser.org/oma/group/A0AAA9SFA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UNA1-1", "protein_name": "Rho GTPase-activating protein 26", "gene_name": "ARHGAP26", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL", "length": 814 }, "evidence": [ { "id": "A0AAA9SFA5", "url": "https://omabrowser.org/oma/group/A0AAA9SFA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X2JDY8-1", "protein_name": "Rho GTPase-activating protein Graf", "gene_name": "Graf", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGGGKNVRRGLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPEEIFTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDEKLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKNKPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRVVSKTNCTEPTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINNLHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQSGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKHYSPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPHLGPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGESEGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHLKPHH", "length": 1025 }, "evidence": [ { "id": "A0AAA9SFA5", "url": "https://omabrowser.org/oma/group/A0AAA9SFA5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" }, { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SFA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 637, "end_pos": 639, "annotation": "n_glycosylation_sequon" }, { "start_pos": 647, "end_pos": 649, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SFA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 265, "end_pos": 369, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 383, "end_pos": 568, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SFA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFA5" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 712, "end_pos": 770, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 671 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 150, "end_pos": 152 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 621, "end_pos": 623 }, { "start_pos": 637, "end_pos": 639 }, { "start_pos": 647, "end_pos": 649 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH98-1", "uniprot_ac": "A0AAA9SH98", "uniprot_id": "A0AAA9SH98_BOVIN", "mass": { "chemical_mass": 164308.0, "monoisotopic_mass": 164308.0 }, "refseq": { "ac": "XP_002697144", "name": "FYVE and coiled-coil domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697144" }, "gene_names": [ { "name": "FYCO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ] }, { "name": "FYCO1", "type": "synonym", "evidence": [ { "id": "XP_002697144", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697144" } ] } ], "protein_names": [ { "name": "FYVE and coiled-coil domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98/entry#names_and_taxonomy" } ] }, { "name": "FYVE and coiled-coil domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "XP_002697144", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697144" } ] } ], "function": [ { "annotation": "May mediate microtubule plus end-directed vesicle transport.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M133", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M133#function" }, { "database": "UniProtKB", "id": "ARBA00055152", "url": "https://www.uniprot.org/uniprotkb/ARBA00055152#function" }, { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98#function" }, { "database": "UniProtKB", "id": "G3MZW6", "url": "https://www.uniprot.org/uniprotkb/G3MZW6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FYCO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98", "locus": { "chromosome": "22", "start_pos": 53401616, "end_pos": 53325781, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015698", "url": "https://www.ensembl.org/id/ENSBTAG00000015698" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015698", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015698", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15726", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15726", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17698", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17698", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100139246", "url": "https://www.ncbi.nlm.nih.gov/gene/100139246", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100139246", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139246", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KERCCSD", "url": "https://omabrowser.org/oma/group/KERCCSD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M133", "url": "https://www.orthodb.org/?gene=A0A3Q1M133", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZW6", "url": "https://www.orthodb.org/?gene=G3MZW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N2N5", "url": "https://www.orthodb.org/?gene=G3N2N5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46753:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46753:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01363", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01363", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697144", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697144", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M133", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M133", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M133-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M133-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZW6", "url": "https://www.uniprot.org/uniprotkb/G3MZW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZW6-1", "url": "https://www.uniprot.org/uniprotkb/G3MZW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2N5", "url": "https://www.uniprot.org/uniprotkb/G3N2N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2N5-1", "url": "https://www.uniprot.org/uniprotkb/G3N2N5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTSAESQLQRIIRDLQDAVTELSRESKEAGEPITDDSTNLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTDVQFDLASRGYDLDAAWPTFARRTLATSSSAYLWRPPSRSSSMSSLVSSYLQTQEMASSLDLSNPLNSESLEGFDEMRLELDQLEVREKQLQERMQQLDRENQELKAAISLQGEQLQVERERGRATAEDNSRLADMVAALQKQWEVTQAMQNTMVELHTCLQALELGAAEKEEDYRSALRRLESLLKPLARDLKATHDSPHRRNQDIPAANVLEQLAAAEQMAAPALDAKEREERVYSDSALETQELAVRLQALESKNPRIQELSGQQAVQLEPLAGELQLKEEAQTCLERLVEETALLRDELSCKGQEAAQLRRQLQESLGHLGSLEEELTEARREARQRLEEKELLEQEARSLTRQLQLLETQLAQVSQHVSDLEEQKKQLIQDRDHLSQKVGMLEQLAAQLGPGLPDEAETLEALNSVPQQACEMPEEEQRGLREGQTDNPRVHGTGMEDQLQQAHRELEKELQNVAERNHILEEKLQALQADYQALQQREAASQGSLAFLESEQTEASMWAHMAEKEAALQSKEAECRRLREQVEQGQQLAEARDGELQALAGQCQQQTQLIETLRADGGQQGLSPPEDHAPQELAVQLALSQAQLEIHQGEARRLQAMVVELQAKLQAALGDQEKVKSQLSVAETALTEHKALVQRLKEQNEALNRAHVQELLQCSEREGALREERAEEAERREEELQILREELSRVRCSSEEAHLEHTELQEQLHHANMDTAELGIQVCALTAEKERVEGALAHTIQELREAQEAASREREGLEHQVAGLRREKESLQEQLRVAEETAGSLPGLQARLAQAEQHAQSLQEASRQELDTLKFQLSTEMMDYQKRLKTSSEECRTLRGQLEEQGRQLQATKEAEGKLKAAQADVQEKLSCTSKHLAECQAAMLRKDEEGAALRQDLDRTQKELERATTKAQEYYNRLCQEAAEREKNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWPGDMEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYAVSKHGGKKERCCRACFRKLSESPGSPNSSSSGTSQGEPSPTRSPAQATGGQGANTDCRPPDDAAFDIITDEELCQIQESGSSLPETPTETDSLDPNVAEQDTTSTSLTPEDAEDMPVGQDSEICLLKSGELMIKLPLTVEEIANFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYLLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFP", "length": 1454, "header": "tr|A0AAA9SH98-1|A0AAA9SH98_BOVIN Isoform 1 of FYVE and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=FYCO1 PE=4 SV=2 CANONICAL=A0AAA9SH98-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M133-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98/entry#A0A3Q1M133-1", "sequence": { "sequence": "MASTSAESQLQRIIRDLQDAVTELSRESKEAGEPITDDSTNLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTDVQFDLASRGYDLDAAWPTFARRTLATSSSAYLWRPPSRSSSMSSLVSSYLQTQEMASSLDLSNPLNSESLEGFDEMRLELDQLEVREKQLQERMQQLDRENQELKAAISLQGEQLQVERERGRATAEDNSRLADMVAALQKQWEVTQAMQNTMVELHTCLQALELGAAEKEEDYRSALRRLESLLKPLARDLKATHDSPHRRNQDIPAANVLEQLAAAEQMAAPALDAKEREERVYSDSALETQELAVRLQALESKNPRIQELSGQQAVQLEPLAGELQLKEEAQTCLERLVEETALLRDELSCKGQEAAQLRRQLQESLGHLGSLEEELTEARREARQRLEEKELLEQEARSLTRQLQLLETQLAQVSQHVSDLEEQKKQLIQDRDHLSQKVGMLEQLAAQLGPGLPDEAETLEALNSVPQQACEMPEEEQRGLREGQTDNPRVHGTGMEDQLQQAHRELEKELQNVAERNHILEEKLQALQADYQALQQREAASQGSLAFLESEQTEASMWAHMAEKEAALQSKEAECRRLREQVEQGQQLAEARDGELQALAGQCQQQTQLIETLRADGGQQGLSPPEDHAPQELAVQLALSQAQLEIHQGEARRLQAMVVELQAKLQAALGDQEKVKSQLSVAETALTEHKALVQRLKEQNEALNRAHVQELLQCSEREGALREERAEEAERREEELQILREELSRVRCSSEEAHLEHTELQEQLHHANMDTAELGIQVCALTAEKERVEGALAHTIQELREAQEAASREREGLEHQVAGLRREKESLQEQLRVAEETAGSLPGLQARLAQAEQHAQSLQEASRQELDTLKFQLSTEMMDYQKRLKAAQADVQEKLSCTSKHLAECQAAMLRKDEEGAALRQDLDRTQKELERATTKAQEYYNRLCQEAAEREKNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWPGDMEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYAVSKHGGKKERCCRACFRKLSESPGSPNSSSSGTSQGEPSPTRSPAQATGGQGANTDCRPPDDAAFDIITDEELCQIQESGSSLPETPTETDSLDPNVAEQDTTSTSLTPEDAEDMPVGQDSEICLLKSGELMIKLPLTVEEIANFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYLLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFP", "length": 1423, "header": "tr|A0A3Q1M133-1|A0A3Q1M133_BOVIN Computationally mapped isoform of FYVE and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=FYCO1 PE=4 SV=3 CANONICAL=A0AAA9SH98-1" }, "locus": { "chromosome": "22", "start_pos": 53400612, "end_pos": 53336390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066882.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066882.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063674.3", "url": "https://www.ensembl.org/id/ENSBTAP00000063674.3" } ] } }, { "isoform_ac": "A0AAA9SH98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98/entry#A0AAA9SH98-1", "sequence": { "sequence": "MASTSAESQLQRIIRDLQDAVTELSRESKEAGEPITDDSTNLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTDVQFDLASRGYDLDAAWPTFARRTLATSSSAYLWRPPSRSSSMSSLVSSYLQTQEMASSLDLSNPLNSESLEGFDEMRLELDQLEVREKQLQERMQQLDRENQELKAAISLQGEQLQVERERGRATAEDNSRLADMVAALQKQWEVTQAMQNTMVELHTCLQALELGAAEKEEDYRSALRRLESLLKPLARDLKATHDSPHRRNQDIPAANVLEQLAAAEQMAAPALDAKEREERVYSDSALETQELAVRLQALESKNPRIQELSGQQAVQLEPLAGELQLKEEAQTCLERLVEETALLRDELSCKGQEAAQLRRQLQESLGHLGSLEEELTEARREARQRLEEKELLEQEARSLTRQLQLLETQLAQVSQHVSDLEEQKKQLIQDRDHLSQKVGMLEQLAAQLGPGLPDEAETLEALNSVPQQACEMPEEEQRGLREGQTDNPRVHGTGMEDQLQQAHRELEKELQNVAERNHILEEKLQALQADYQALQQREAASQGSLAFLESEQTEASMWAHMAEKEAALQSKEAECRRLREQVEQGQQLAEARDGELQALAGQCQQQTQLIETLRADGGQQGLSPPEDHAPQELAVQLALSQAQLEIHQGEARRLQAMVVELQAKLQAALGDQEKVKSQLSVAETALTEHKALVQRLKEQNEALNRAHVQELLQCSEREGALREERAEEAERREEELQILREELSRVRCSSEEAHLEHTELQEQLHHANMDTAELGIQVCALTAEKERVEGALAHTIQELREAQEAASREREGLEHQVAGLRREKESLQEQLRVAEETAGSLPGLQARLAQAEQHAQSLQEASRQELDTLKFQLSTEMMDYQKRLKTSSEECRTLRGQLEEQGRQLQATKEAEGKLKAAQADVQEKLSCTSKHLAECQAAMLRKDEEGAALRQDLDRTQKELERATTKAQEYYNRLCQEAAEREKNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWPGDMEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYAVSKHGGKKERCCRACFRKLSESPGSPNSSSSGTSQGEPSPTRSPAQATGGQGANTDCRPPDDAAFDIITDEELCQIQESGSSLPETPTETDSLDPNVAEQDTTSTSLTPEDAEDMPVGQDSEICLLKSGELMIKLPLTVEEIANFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYLLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFP", "length": 1454, "header": "tr|A0AAA9SH98-1|A0AAA9SH98_BOVIN Isoform 1 of FYVE and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=FYCO1 PE=4 SV=2 CANONICAL=A0AAA9SH98-1" }, "locus": { "chromosome": "22", "start_pos": 53400612, "end_pos": 53336390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120459.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120459.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085583.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085583.2" } ] } }, { "isoform_ac": "G3MZW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98/entry#G3MZW6-1", "sequence": { "sequence": "MASTSAESQLQRIIRDLQDAVTELSRESKEAGEPITDDSTNLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTDVQFDLASRGYDLDAAWPTFARRTLATSSSAYLWRPPSRSSSMSSLVSSYLQTQEMASSLDLSNPLNSESLEGFDEMRLELDQLEVREKQLQERMQQLDRENQELKAAISLQGEQLQVERERGRATAEDNSRLADMVAALQKQWEVTQAMQNTMVELHTCLQALELGAAEKEEDYRSALRRLESLLKPLARDLKATHDSPHRRNQDIPAANVLEQLAAAEQMAAPALDAKEREERVYSDSALETQELAVRLQALESKNPRIQELSGQQAVQLEPLAGELQLKEEAQTCLERLVEETALLRDELSCKGQEAAQLRRQLQESLGHLGSLEEELTEARREARQRLEEKELLEQEARSLTRQLQLLETQLAQVSQHVSDLEEQKKQLIQDRDHLSQKVGMLEQLAAQLGPGLPDEAETLEALNSVPQQACEMPEEEQRGLREGQTDNPRVHGTGMEDQLQQAHRELEKELQNVAERNHILEEKLQALQADYQALQQREAASQGSLAFLESEQTEASMWAHMAEKEAALQSKEAECRRLREQVEQGQQLAEARDGELQALAGQCQQQTQLIETLRADGGQQGLSPPEDHAPQELAVQLALSQAQLEIHQGEARRLQAMVVELQAKLQAALGDQEKVKSQLSVAETALTEHKALVQRLKEQNEALNRAHVQELLQCSEREGALREERAEEAERREEELQILREELSRVRCSSEEAHLEHTELQEQLHHANMDTAELGIQVCALTAEKERVEGALAHTIQELREAQEAASREREGLEHQVAGLRREKESLQEQLRVAEETAGSLPGLQARLAQAEQHAQSLQEASRQELDTLKFQLSTEMMDYQKRLKTSSEECRTLRGQLEEQGRQLQATKEAEGKLKAAQADVQEKLSCTSKHLAECQAAMLRKDEEGAALRQDLDRTQKELERATTKAQEYYNRLCQEAAEREKNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWPGDMEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYAVSKHGGKKERCCRACFRKLSESPGSPNSSSSGTSQGEPSPTRSPAQATGGQGANTDCRPPDDAAFDIITDEELCQIQESGSSLPETPTETDSLDPNVAEQIKLPLTVEEIANFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYLLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFP", "length": 1422, "header": "tr|G3MZW6-1|G3MZW6_BOVIN Computationally mapped isoform of FYVE and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=FYCO1 PE=4 SV=4 CANONICAL=A0AAA9SH98-1" }, "locus": { "chromosome": "22", "start_pos": 53400612, "end_pos": 53336390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063071.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063071.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055120.4", "url": "https://www.ensembl.org/id/ENSBTAP00000055120.4" } ] } }, { "isoform_ac": "G3N2N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98/entry#G3N2N5-1", "sequence": { "sequence": "MGSDSSSPSRSDWYYARSPFLKPKLSSDIVGQLYELTDVQFDLASRGYDLDAAWPTFARRTLATSSSAYLWRPPSRSSSMSSLVSSYLQTQEMASSLDLSNPLNSESLEGFDEMRLELDQLEVREKQLQERMQQLDRENQELKAAISLQGEQLQVERERGRATAEDNSRLADMVAALQKQWEVTQAMQNTMVELHTCLQALELGAAEKEEDYRSALRRLESLLKPLARDLKATHDSPHRRNQDIPAANVLEQLAAAEQMAAPALDAKEREERVYSDSALETQELAVRLQALESKNPRIQELSGQQAVQLEPLAGELQLKEEAQTCLERLVEETALLRDELSCKGQEAAQLRRQLQESLGHLGSLEEELTEARREARQRLEEKELLEQEARSLTRQLQLLETQLAQVSQHVSDLEEQKKQLIQDRDHLSQKVGMLEQLAAQLGPGLPDEAETLEALNSVPQQACEMPEEEQRGLREGQTDNPRVHGTGMEDQLQQAHRELEKELQNVAERNHILEEKLQALQADYQALQQREAASQGSLAFLESEQTEASMWAHMAEKEAALQSKEAECRRLREQVEQGQQLAEARDGELQALAGQCQQQTQLIETLRADGGQQGLSPPEDHAPQELAVQLALSQAQLEIHQGEARRLQAMVVELQAKLQAALGDQEKVKSQLSVAETALTEHKALVQRLKEQNEALNRAHVQELLQCSEREGALREERAEEAERREEELQILREELSRVRCSSEEAHLEHTELQEQLHHANMDTAELGIQVCALTAEKERVEGALAHTIQELREAQEAASREREGLEHQVAGLRREKESLQEQLRVAEETAGSLPGLQARLAQAEQHAQSLQEASRQELDTLKFQLSTEMMDYQKRLKTSSEECRTLRGQLEEQGRQLQATKEAEGKLKAAQADVQEKLSCTSKHLAECQAAMLRKDEEGAALRQDLDRTQKELERATTKAQEYYNRLCQEAAEREKNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWPGDMEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYAVSKHGGKKERCCRACFRKLSESPGSPNSSSSGTSQGEPSPTRSPAQATGGQGANTDCRPPDDAAFDIITDEELCQIQESGSSLPETPTETDSLDPNVAEQDTTSTSLTPEDAEDMPVGQDSEICLLKSGELMIKLPLTVEEIANFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYLLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFP", "length": 1333, "header": "tr|G3N2N5-1|G3N2N5_BOVIN Computationally mapped isoform of FYVE and coiled-coil domain autophagy adaptor 1 OS=Bos taurus OX=9913 GN=FYCO1 PE=4 SV=3 CANONICAL=A0AAA9SH98-1" }, "locus": { "chromosome": "22", "start_pos": 53400612, "end_pos": 53341997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065084.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065084.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056152.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056152.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100139246", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139246", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z2G0-1", "protein_name": "FYVE and coiled-coil domain-containing protein 1", "gene_name": "FYCO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAAPGESQLQRIIRDLQDAVAELSKEFKEGGEPITDDSVNLQKFSYKLEYLLQFDQKEKSTLLGNRKDYWDYFCDCLAKVKGANDGIRFVKSITELRTSLGKGRAFLRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLNPKMSSDIVGQLYELTDVQFDLASRGYDLDAAWPAFARRTLSSLGSSAYLWKPPSRSSSMSSLVSNYLQAPEFPSSPDANNSLNAEHFEGFEEMRVELDQAELRQKELQRSIHQLEMENQELQAAVSLQKEQLQLEKEKSNNYSEENSRLTKMITELQKQCEVSHSTQSTVHDLQKCLQSLELNAVEQQKEYSTKLAQLATSKEDYASKLQLLNEELEVSRALVAMKELCIDELKAKLSSTEQKNLNLLAKVDAALEEKGHQAMAQCDSALQIQALLEKLQQTEKEKAEMQRLSDECTSQLKTAEEQLRLKEEAQKELESRYNCLTADSREGSEKLLRSLETMEKEVDALQKALTLKEKKMAELQTQVMESLAQVGSLEKDLEEARKEKEKLKEEYGKMEEALKEEAQSQAEKFEQQEGHLKKVSETVCSLEEQKRKLLYEKEHLSQKVKELEEQMRQQNSTVNEMSEESRKLKTENVDLQQSKKKVEEKLKNLEASKDSLEAEVARLRASEKQLQSEIDDALVSVDEKEKKLRSQNKQLDEDLQNARRQSQILEEKLEALQSDYRELKEREETTRESYASLEGQLKGAKQHSLQVEKSLDTLKESKESLQSQLAEKEIQLQGMECQCEQLRKEAERHRKKAETLEVEKLSAENTCLQQTKLIESLTSEKESMEKHQLQQAASLEKDAKELASRLTVSEEQLQVNRDEVSRLQTEVLDLRVKLQQTTDEREQLKSELAITETVLGEQKMLVQQLKEQTESLNRNHVQELVQCKEREEVLKREQEAVVLQKTELENNLLSLKEELSKFKQYLEAARMENVENKDLLHRTNTDMAELGIQICALSSEKVDAEEQLAQAKERLKELEEQAAMQQEKLKHDISNLRQENRSLQEKLEEAQICVSAVPSLQAQLETAKKQAQSFQETSQEELSAIKFQMSTEILNYQTKFKTASEECGKLRDQLEEQKRQQHATEEEIAGLQAENTSLSRKLDEAREQLSELQSARLQKEEEVTSLRELLERTQKEADEAKNQALDYSEKLSKMAADKDSNDQKLFAELDDLTRTKQFLEERLIELIRDKDALWQKSDALEFQQKLSAEQKWQGDTEVNHCLDCQREFSWMVRRHHCRMCGRIFCYYCCNNYMVTKPGGRKERCCKACFNKPRVIVDNTDDSGSSANQEGSPGSLESPVSPVAGEVSKPPDDAAFDIITDEELCQVQESDSLHSESQMDRDSLDQSVTDLPVIHSSWYSRVYPVHLPFWRNSTCNSSTFDESEEWQVAQDAEISLLKSGEIMVKLPLTVEEIMNFGEGNRELFIKSSTYSIIPITVTEIGLTISWIFSSDPKSISFSVVYQESEDTPLDQCKVLIPMTRCNSHKETIRGQMKVRNSGIYTLIFDNTFSRFISKRVFYQLTVERPVIYDGSDFP", "length": 1560 }, "evidence": [ { "id": "A0AAA9SH98", "url": "https://omabrowser.org/oma/group/A0AAA9SH98/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3Z9D2-1", "protein_name": "FYVE and coiled-coil domain-containing protein 1", "gene_name": "Fyco1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSSTETQLQRIIRDLQDAVTELSNEFKEGGEPITDDSTSLHKFSYKLEYLLQFDQKEKASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEVQFDLASRGYDLDAAWPTFARRTLATSSSYMWKPPSRSSSMSSLVSNYLQTQEMASSLDLNSSLNNEALESFDEMRLELDQLEVREKQLQEHVQQLNRENQALRMTISKQGGQLQVEKETGYLAVEDSIDLVSLVAELQKQGEVTQATVKKLQTCLQALELAVDQKETSHSVLQLENVAQALDAVRDSLGRKNQLLASLSECLTRAEKREHPSLDTKLHQEPVPTDLALKFQELKGKLQTLEGENTKAQELNRQQSLKLEQLAKELQLKEEARASLEHLVKDAVPLQEELSGKKQESAQLRRQLQESLAHLSSVEEELAEARQQEKQHREEKQLLEQEAKSLTWQLQLLETQLGQVSQLVSDLEEQKKQLMQDKDHLSQKVGTLEQLAEAHGASKSKEAVPPQAGEMPEKGQHCLQEEQVNNATVRGADQDELQKVNQELQKELQNMAVRNQLLEGKLQALQTDYKALQQREAAIQGSLASLEAEQASIRQLGNQMEASLLAVRKAKETMKAQVAEKEAALQSKEGECRQLQEEAEQCRLRTEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVNTAQLALSQAQLEIHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAEAVLGEHKTLVQQLKEQNEALNRAHIQELLQCSEREGILQEESIYKAQKQEQELRALQAELSQVRCSSEGAHLEHAELQDQLHRANTDTAELGIQVCALTAEKDRMEGALASLAQELQDSKEAALQERKGLELQVMQLQQEKESLQEKLKATEEAASSFSVLQAQLAQAEQLAQSLQEAAHQEQDALKFQLSAEIMDHQNRLKTANEECGSLRAQLEEQGQELQMTKEAVQELKITKATMEEKLNCTGSHLAECQATLLRKDEESAMLRINLERTQKELEKATSKFQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGDMEANHCHDCKREFSWIVRRHHCRLCGRIFCYYCCNNYVVTKPSGKKERCCRACFQKFGESSGSPDSSGSGTSQGEPSPMVSPAEAAPQSIGSQGINPVCRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSMDPNMAEQDTTSNSLTPEDTEDMPLGQDAEICLLKSGELMIKLPLTVEEIASFGEGNRELFVRSSTYSLIPITVAEPGLTISWVFSSDPKSISFSVVFQETEDTPLDQCKVLIPTTRCNSHKESIRGQLKVRTPGIYLLIFDNTFSRFISKKVFYHLTVDRPVIYDGSDFP", "length": 1451 }, "evidence": [ { "id": "A0AAA9SH98", "url": "https://omabrowser.org/oma/group/A0AAA9SH98/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VDC1-1", "protein_name": "FYVE and coiled-coil domain-containing protein 1", "gene_name": "Fyco1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSSTETQLQRIIRDLQDAATELSHEFKEGGEPITDDSTSLHKFSYKLEYLLQFDQKEKASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEVQFDLAPRGYDLDAAWPTFARRTLATSTSAYMWKPPSRSSSMSSLVSNYLQTQEMASSLDLNCSLNNEALESFDEMRLELDQLEVREKQLQERVQQLDRENQALRMLVSRQGGQLQVEKEMGYLAVEDSIGLVSLVAELQKQGDVSQATVKKLQSCLQALELNVDKKEYSPSALQLENMAKELDTVRGSLGRENQLLASLSERLARAEKGEKTPPDTELHQEPVPADLVLKFQELKGKLQALEGENTEAQELNRQQSIKLEQLAKELQLKEEARASLAHLVKDVVPLQEELSGKKQESAQLRRQLQESLAHLSSVEEELAEARQQEKQHREEKQLLEQEATSLTWQLQLLETQLGQVSQLVSDLEEQKKQLMQERDHLSQRVGTLEQLAEVHGPPQSAEMPEKRQQCLREEQVNNSTVSEAEQEELQKELQNMVDRNQLLEGKLQALQTDYKALQQREAAIQGSLASLEAEQASIRHLGNQMEASLLAVKKAKETMKAQVAEKEAALQSKESECQRLQEEADQCRLQAEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVNTDQLALSQAQLEIHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAETVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGILQEESIYKAQKQEQELRALQAELSQVRCSSEGAHLEHAELQDQLHRANTDTAELGIQVCALTAEKDRMEEALASLAQELQDSKEAALQERKGLELQVMQLQQEKEKLQEKVKAAEEAASSFSGLQAQLAQAEQLAQSLQETAHQEQDALKFQLSAEIMDHQNRLKTANEECGHLRAQLEEQGQQLQMTKEAVQELEITKAAMEEKLNCTSSHLAECQATLLRKDEESTMLQTSLERTQKELEKATSKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGDMEVNHCHDCKREFSWIVRRHHCRICGRIFCYYCCNNYVVTKPSGKKERCCRACFQKFGEGSGSNDSSGSGTSQGEPSPMVSPAEASPQSIGSQGINSVCRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSMDPNTAEQDTTSNSLTPEDTEDVPMGQDAEICLLKSGELMIKLPLTVEEVASFGEGSRELFVRSSTYSLITITVAEPGLTISWVFSSDPKSISFSVVFQETEDTPLDQCKVLIPTTRCNSHKENIRGQLKVRIPGIYLLIFDNTFSRFISKKVLYHLTVDRPVIYDGSDFP", "length": 1437 }, "evidence": [ { "id": "A0AAA9SH98", "url": "https://omabrowser.org/oma/group/A0AAA9SH98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQS8-1", "protein_name": "FYVE and coiled-coil domain-containing protein 1", "gene_name": "FYCO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGPQATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTSTSLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL", "length": 1478 }, "evidence": [ { "id": "A0AAA9SH98", "url": "https://omabrowser.org/oma/group/A0AAA9SH98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of autophagosome maturation", "id": "GO:1901098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901098", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "pmid": "" }, { "name": "plus-end-directed vesicle transport along microtubule", "id": "GO:0072383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072383", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1111, "end_pos": 1113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1218, "end_pos": 1220, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" }, { "id": "PS50178", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FYVE-type", "eco_id": "ECO_0000259", "start_pos": 1153, "end_pos": 1211, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" }, { "id": "PS50866", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GOLD", "eco_id": "ECO_0000259", "start_pos": 1313, "end_pos": 1442, "start_aa": "Glu", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH98" }, { "id": "PS50826", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50826" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RUN", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 169, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1111, "end_pos": 1113 }, { "start_pos": 1218, "end_pos": 1220 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SEX2-1", "uniprot_ac": "A0AAA9SEX2", "uniprot_id": "A0AAA9SEX2_BOVIN", "mass": { "chemical_mass": 26392.0, "monoisotopic_mass": 26392.0 }, "refseq": { "ac": "XP_024836586", "name": "tumor necrosis factor receptor superfamily member 13B isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836586" }, "gene_names": [ { "name": "TNFRSF13B", "type": "recommended", "evidence": [ { "id": "A0AAA9SEX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ] }, { "name": "TNFRSF13B", "type": "synonym", "evidence": [ { "id": "XP_024836586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836586" } ] } ], "protein_names": [ { "name": "TNF receptor superfamily member 13B", "type": "synonym", "evidence": [ { "id": "A0AAA9SEX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2/entry#names_and_taxonomy" } ] }, { "name": "tumor necrosis factor receptor superfamily member 13B isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024836586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836586" } ] } ], "function": [ { "annotation": "Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RXN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXN2#function" }, { "database": "UniProtKB", "id": "ARBA00058588", "url": "https://www.uniprot.org/uniprotkb/ARBA00058588#function" }, { "database": "UniProtKB", "id": "F1MU29", "url": "https://www.uniprot.org/uniprotkb/F1MU29#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFRSF13B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2", "locus": { "chromosome": "19", "start_pos": 35117894, "end_pos": 35095158, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015298", "url": "https://www.ensembl.org/id/ENSBTAG00000015298" } ] } } ], "crossref": [ { "id": "A0AAA9SEX2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SEX2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015298", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13415", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13415", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617948", "url": "https://www.ncbi.nlm.nih.gov/gene/617948", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617948", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617948", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CESMDCN", "url": "https://omabrowser.org/oma/group/CESMDCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MU29", "url": "https://www.orthodb.org/?gene=F1MU29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15511", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15511", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15511:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15511:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09305", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09305", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024836586", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836586", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU29", "url": "https://www.uniprot.org/uniprotkb/F1MU29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU29-1", "url": "https://www.uniprot.org/uniprotkb/F1MU29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGLGRRGQGGRGLAGQEEPKSLSCRQEQGRYYDLLLRDCVSCASICGRHPKQCTHYCEKTLRSQVSLLPEVRRQRAGEAPTRADTLGRHQVPEHRGLDAGPAPAGLKLSADQLALVYSTLGLCLCAIVCCFLLAVACFLKRRGVQVSFPTRPRPCPTQAKTSKDHWMEAGCVAGTPPEPVETCSFCFPECRAPTQESAGAPPTPGSERTGRRARQGQSTAGQPCVRAANGGIEVVYTPAQEGGLAT", "length": 247, "header": "tr|A0AAA9SEX2-1|A0AAA9SEX2_BOVIN Isoform 1 of TNF receptor superfamily member 13B OS=Bos taurus OX=9913 GN=TNFRSF13B PE=4 SV=1 CANONICAL=A0AAA9SEX2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2/entry#A0AAA9RXN2-1", "sequence": { "sequence": "MPTRPAPQGPRRGVAMEPCPEEQYWDSLLNTCVSCKPICSSQIPRTCAAFCKSLSCRQEQGRYYDLLLRDCVSCASICGRHPKQCTHYCEKTLRSQVSLLPEVRRQRAGEAPTRADTLGRHQVPEHRGLDAGPAPAGLKLSADQLALVYSTLGLCLCAIVCCFLLAVACFLKRRGVQVSFPTRPRPCPTQAKTSKDHWMEAGCVAGTPPEPVETCSFCFPECRAPTQESAGAPPTPGSERTGRRARQGQSTAGQPCVRAANGGIEVVYTPAQEGGLAT", "length": 278, "header": "tr|A0AAA9RXN2-1|A0AAA9SEX2_BOVIN Computationally mapped isoform of TNF receptor superfamily member 13B OS=Bos taurus OX=9913 GN=TNFRSF13B PE=4 SV=1 CANONICAL=A0AAA9SEX2-1" }, "locus": { "chromosome": "19", "start_pos": 35117878, "end_pos": 35097077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126605.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126605.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075908.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075908.1" } ] } }, { "isoform_ac": "A0AAA9SEX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2/entry#A0AAA9SEX2-1", "sequence": { "sequence": "MSGLGRRGQGGRGLAGQEEPKSLSCRQEQGRYYDLLLRDCVSCASICGRHPKQCTHYCEKTLRSQVSLLPEVRRQRAGEAPTRADTLGRHQVPEHRGLDAGPAPAGLKLSADQLALVYSTLGLCLCAIVCCFLLAVACFLKRRGVQVSFPTRPRPCPTQAKTSKDHWMEAGCVAGTPPEPVETCSFCFPECRAPTQESAGAPPTPGSERTGRRARQGQSTAGQPCVRAANGGIEVVYTPAQEGGLAT", "length": 247, "header": "tr|A0AAA9SEX2-1|A0AAA9SEX2_BOVIN Isoform 1 of TNF receptor superfamily member 13B OS=Bos taurus OX=9913 GN=TNFRSF13B PE=4 SV=1 CANONICAL=A0AAA9SEX2-1" }, "locus": { "chromosome": "19", "start_pos": 35117878, "end_pos": 35095462, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111554.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111554.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082389.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082389.1" } ] } }, { "isoform_ac": "F1MU29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2/entry#F1MU29-1", "sequence": { "sequence": "MSGLGRRGQGGRGLAGQEEPTPQGPRRGVAMEPCPEEQYWDSLLNTCVSCKPICSSQIPRTCAAFCKSLSCRQEQGRYYDLLLRDCVSCASICGRHPKQCTHYCEKTLRSQVSLLPEVRRQRAGEAPTRADTLGRHQVPEHRGLDAGPAPAGLKLSADQLALVYSTLGLCLCAIVCCFLLAVACFLKRRGVQVSFPTRPRPCPTQAKTSKDHWMEAGCVAGTPPEPVETCSFCFPECRAPTQESAGAPPTPGSERTGRRARQGQSTAGQPCVRAANGGIEVVYTPAQEGGLAT", "length": 293, "header": "tr|F1MU29-1|F1MU29_BOVIN Computationally mapped isoform of Tumor necrosis factor receptor superfamily member 13B OS=Bos taurus OX=9913 GN=TNFRSF13B PE=4 SV=3 CANONICAL=A0AAA9SEX2-1" }, "locus": { "chromosome": "19", "start_pos": 35117878, "end_pos": 35095462, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020341.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020341.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020341.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020341.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 158, "start_aa": "Thr", "end_pos": 158, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr158", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 204, "start_aa": "Thr", "end_pos": 204, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr204", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617948", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617948", "resource": "KEGG Pathway" }, { "id": "R-BTA-5669034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5669034", "resource": "Reactome", "description": "TNFs bind their physiological receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "O14836-1", "protein_name": "Tumor necrosis factor receptor superfamily member 13B", "gene_name": "TNFRSF13B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYSTLGLCLCAVLCCFLVAVACFLKKRGDPCSCQPRSRPRQSPAKSSQDHAMEAGSPVSTSPEPVETCSFCFPECRAPTQESAVTPGTPDPTCAGRWGCHTRTTVLQPCPHIPDSGLGIVCVPAQEGGPGA", "length": 293 }, "evidence": [ { "id": "A0AAA9SEX2", "url": "https://omabrowser.org/oma/group/A0AAA9SEX2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ET35-1", "protein_name": "Tumor necrosis factor receptor superfamily member 13B", "gene_name": "Tnfrsf13b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMAFCPKDQYWDSSRKSCVSCALTCSQRSQRTCTDFCKFINCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKRPRSQANLQPELGRPQAGEVEVRSDNSGRHQGSEHGPGLRLSSDQLTLYCTLGVCLCAIFCCFLVALASFLRRRGEPLPSQPAGPRGSQANSPHAHRPVTEACDEVTASPQPVETCSFCFPERSSPTQESAPRSLGIHGFAGTAAPQPCMRATVGGLGVLRASTGDARPAT", "length": 249 }, "evidence": [ { "id": "A0AAA9SEX2", "url": "https://omabrowser.org/oma/group/A0AAA9SEX2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ], "pmid": "" }, { "name": "negative regulation of B cell proliferation", "id": "GO:0030889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030889", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ], "pmid": "" }, { "name": "B cell homeostasis", "id": "GO:0001782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001782", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SEX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SEX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEX2" }, { "id": "PF09305", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09305" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TACI cysteine-rich", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 61, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 158, 204 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SH90-1", "uniprot_ac": "A0AAA9SH90", "uniprot_id": "A0AAA9SH90_BOVIN", "mass": { "chemical_mass": 42786.0, "monoisotopic_mass": 42786.0 }, "refseq": {}, "gene_names": [ { "name": "DAPK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ], "protein_names": [ { "name": "Death-associated protein kinase 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#names_and_taxonomy" } ] }, { "name": "DAP-kinase-related protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DAPK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90", "locus": { "chromosome": "10", "start_pos": 46089594, "end_pos": 45905873, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011820", "url": "https://www.ensembl.org/id/ENSBTAG00000011820" } ] } } ], "crossref": [ { "id": "A0AAA9SH90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SH90", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011820", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011820", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14196", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14196", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MHX3", "url": "https://www.orthodb.org/?gene=F1MHX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24342", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24342", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24342:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24342:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHX3", "url": "https://www.uniprot.org/uniprotkb/F1MHX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHX3-1", "url": "https://www.uniprot.org/uniprotkb/F1MHX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TLQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSPASRRGVCREEIEREVSILRQVLHPNVITLHDVFENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILEGVNYLHAKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIMPVDSQQALMRRESVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKMHPRRNEDLRNCESDTEEDIAKRKVLHPRRRSSTS", "length": 370, "header": "tr|A0AAA9SH90-1|A0AAA9SH90_BOVIN Isoform 1 of Death-associated protein kinase 2 OS=Bos taurus OX=9913 GN=DAPK2 PE=3 SV=2 CANONICAL=A0AAA9SH90-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#A0AAA9SBS8-1", "sequence": { "sequence": "MHPQGCTLQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSPASRRGVCREEIEREVSILRQVLHPNVITLHDVFENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILEGVNYLHAKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIMPVDSQQALMRRESVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKMHPRRNEDLFIKTGHRSHWPGKTTRQDWLKRNCESDTEEDIAKRKVLHPRRRSSTS", "length": 397, "header": "tr|A0AAA9SBS8-1|A0AAA9SH90_BOVIN Computationally mapped isoform of Death-associated protein kinase 2 OS=Bos taurus OX=9913 GN=DAPK2 PE=3 SV=1 CANONICAL=A0AAA9SH90-1" }, "locus": { "chromosome": "10", "start_pos": 46088590, "end_pos": 45956733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101656.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101656.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079686.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079686.1" } ] } }, { "isoform_ac": "A0AAA9SH90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#A0AAA9SH90-1", "sequence": { "sequence": "TLQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSPASRRGVCREEIEREVSILRQVLHPNVITLHDVFENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILEGVNYLHAKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIMPVDSQQALMRRESVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKMHPRRNEDLRNCESDTEEDIAKRKVLHPRRRSSTS", "length": 370, "header": "tr|A0AAA9SH90-1|A0AAA9SH90_BOVIN Isoform 1 of Death-associated protein kinase 2 OS=Bos taurus OX=9913 GN=DAPK2 PE=3 SV=2 CANONICAL=A0AAA9SH90-1" }, "locus": { "chromosome": "10", "start_pos": 46088590, "end_pos": 45958683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096925.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096925.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083068.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083068.2" } ] } }, { "isoform_ac": "A0AAA9TUC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#A0AAA9TUC3-1", "sequence": { "sequence": "MGCTLQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSPASRRGVCREEIEREVSILRQVLHPNVITLHDVFENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILEGVNYLHAKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIMPVDSQQALMRRESVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKMHPRRNEDLRNCESDTEEDIAKRKVLHPRRRSSTS", "length": 373, "header": "tr|A0AAA9TUC3-1|A0AAA9TUC3_BOVIN Computationally mapped isoform of Death-associated protein kinase 2 OS=Bos taurus OX=9913 GN=DAPK2 PE=3 SV=1 CANONICAL=A0AAA9SH90-1" }, "locus": { "chromosome": "10", "start_pos": 46088590, "end_pos": 45950025, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109877.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109877.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101968.1" } ] } }, { "isoform_ac": "F1MHX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90/entry#F1MHX3-1", "sequence": { "sequence": "TLQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSPASRRGVCREEIEREVSILRQVLHPNVITLHDVFENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILEGVNYLHAKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIMSKGEIRAPEQHKAEPNQLKTKRLREYTLKCHSSMPPNNTYINFERFARVVEDVARVEQGCRALTGAHDTIQDDVETLISIYNEKEAWYREESERARHDLSQLRYEFRKVKSSKKLLREDIRATGSRLGGAARKLDHLQTQFETLRQELSADLQWLQELVGSFQLESGSMDSPGSVFCRDASESFGELLNRSCGEEVLAGLKL", "length": 488, "header": "tr|F1MHX3-1|F1MHX3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=DAPK2 PE=3 SV=4 CANONICAL=A0AAA9SH90-1" }, "locus": { "chromosome": "10", "start_pos": 46074320, "end_pos": 45958683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015689.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015689.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015689.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015689.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "anoikis", "id": "GO:0043276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "regulation of intrinsic apoptotic signaling pathway", "id": "GO:2001242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001242", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "positive regulation of eosinophil chemotaxis", "id": "GO:2000424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "positive regulation of neutrophil chemotaxis", "id": "GO:0090023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "neutrophil migration", "id": "GO:1990266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "autophagosome lumen", "id": "GO:0034423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034423", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SH90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 285, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SG49-1", "uniprot_ac": "A0AAA9SG49", "uniprot_id": "A0AAA9SG49_BOVIN", "mass": { "chemical_mass": 139694.0, "monoisotopic_mass": 139694.0 }, "refseq": { "ac": "XP_005213904", "name": "TBC1 domain family member 4 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213904" }, "gene_names": [ { "name": "TBC1D4", "type": "recommended", "evidence": [ { "id": "A0AAA9SG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ] }, { "name": "TBC1D4", "type": "synonym", "evidence": [ { "id": "XP_005213904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213904" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49/entry#names_and_taxonomy" } ] }, { "name": "Akt substrate of 160 kDa", "type": "synonym", "evidence": [ { "id": "A0AAA9SG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49/entry#names_and_taxonomy" } ] }, { "name": "TBC1 domain family member 4 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005213904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213904" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49", "locus": { "chromosome": "12", "start_pos": 50330163, "end_pos": 50571317, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005760", "url": "https://www.ensembl.org/id/ENSBTAG00000005760" } ] } } ], "crossref": [ { "id": "A0AAA9SG49", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SG49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005760", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005760", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00934", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00934", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534649", "url": "https://www.ncbi.nlm.nih.gov/gene/534649", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534649", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534649", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQMRDPA", "url": "https://omabrowser.org/oma/group/QQMRDPA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPA1", "url": "https://www.orthodb.org/?gene=E1BPA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11830", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11830", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213904", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213904", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPA1", "url": "https://www.uniprot.org/uniprotkb/E1BPA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPPSCIQDEPFPHPLEPEPGTPAQPGPGKPSDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVLLVLSAPFLRCIPAPGAGATGGSGSTAAQPNPAVFIFEHKAQHISRFIHNSQDLTYFAYLIKAQPDDPESQMACHVFRAADPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVTVTHKKAPSSLIDDCIEKFSLHEQQRLRLQSEPRAGDSGEDQAGSEARTPACPVDVLSEEGDGVADTHPVFPAAPSQPGPSSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVLQRKVHENSQKPQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESSEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKAVNDQEENELVILHLRQLCEAKQKTHVHIGEGPLTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSVASEKDYSPGDSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGKAHGVRSPLLRQSSSEQCSDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPMRKSPSAMQQDGLDRSELLPLSPLAPTMEEEPLMIFMSDEDDPEKGEERNKSEELRCLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLTIWDKKLLNCRAKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSAQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSNQETLIMECENFENIVEFLKITLPDMNSSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYACEDSEPIEKLERANSQLKRQNMDLLEKLQIAHAKIQTLESNLENLLTRETKMKSLIRTLEQEKTAYQKAVEQIWKLLPADILANCEPLLRDLNCNPNNKAKTGNKP", "length": 1236, "header": "tr|A0AAA9SG49-1|A0AAA9SG49_BOVIN Isoform 1 of TBC1 domain family member 4 OS=Bos taurus OX=9913 GN=TBC1D4 PE=4 SV=1 CANONICAL=A0AAA9SG49-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49/entry#A0AAA9SG49-1", "sequence": { "sequence": "MEPPSCIQDEPFPHPLEPEPGTPAQPGPGKPSDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVLLVLSAPFLRCIPAPGAGATGGSGSTAAQPNPAVFIFEHKAQHISRFIHNSQDLTYFAYLIKAQPDDPESQMACHVFRAADPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVTVTHKKAPSSLIDDCIEKFSLHEQQRLRLQSEPRAGDSGEDQAGSEARTPACPVDVLSEEGDGVADTHPVFPAAPSQPGPSSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVLQRKVHENSQKPQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESSEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKAVNDQEENELVILHLRQLCEAKQKTHVHIGEGPLTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSVASEKDYSPGDSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGKAHGVRSPLLRQSSSEQCSDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPMRKSPSAMQQDGLDRSELLPLSPLAPTMEEEPLMIFMSDEDDPEKGEERNKSEELRCLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLTIWDKKLLNCRAKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSAQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSNQETLIMECENFENIVEFLKITLPDMNSSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYACEDSEPIEKLERANSQLKRQNMDLLEKLQIAHAKIQTLESNLENLLTRETKMKSLIRTLEQEKTAYQKAVEQIWKLLPADILANCEPLLRDLNCNPNNKAKTGNKP", "length": 1236, "header": "tr|A0AAA9SG49-1|A0AAA9SG49_BOVIN Isoform 1 of TBC1 domain family member 4 OS=Bos taurus OX=9913 GN=TBC1D4 PE=4 SV=1 CANONICAL=A0AAA9SG49-1" }, "locus": { "chromosome": "12", "start_pos": 50540017, "end_pos": 50332402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134844.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134844.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081450.1" } ] } }, { "isoform_ac": "A0AAA9SLK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49/entry#A0AAA9SLK3-1", "sequence": { "sequence": "MEPPSCIQDEPFPHPLEPEPGTPAQPGPGKPSDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVLLVLSAPFLRCIPAPGAGATGGSGSTAAQPNPAVFIFEHKAQHISRFIHNSQDLTYFAYLIKAQPDDPESQMACHVFRAADPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVTVTHKKAPSSLIDDCIEKFSLHEQQRLRLQSEPRAGDSGEDQAGSEARTPACPVDVLSEEGDGVADTHPVFPAAPSQPGPSSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVLQRKVHENSQKPQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESSEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKAVNDQEENELVILHLRQLCEAKQKTHVHIGEGPLTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSVASEKDYSPGDSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGKAHGVRSPLLRQSSSEQCSILPPARRMHKECNSSSSLPSLHTSFSAPSFTAPPFLKSFYQNSGRLSPQYENEISDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPMRKSPSAMQQDGLDRSELLPLSPLAPTMEEEPLMIFMSDEDDPEKGEERNKSEELRCLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLTIWDKKLLNCRAKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSAQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSNQETLIMECENFENIVEFLKITLPDMNSSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYACEDSEPIEKLERANSQLKRQNMDLLEKLQIAHAKIQTLESNLENLLTRETKMKSLIRTLEQEKTAYQKAVEQIWKLLPADILANCEPLLRDLNCNPNNKAKTGNKP", "length": 1291, "header": "tr|A0AAA9SLK3-1|A0AAA9SLK3_BOVIN Computationally mapped isoform of TBC1 domain family member 4 OS=Bos taurus OX=9913 GN=TBC1D4 PE=4 SV=1 CANONICAL=A0AAA9SG49-1" }, "locus": { "chromosome": "12", "start_pos": 50540017, "end_pos": 50332402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088603.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088603.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084836.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084836.1" } ] } }, { "isoform_ac": "A0AAA9TV94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49/entry#A0AAA9TV94-1", "sequence": { "sequence": "MEPPSCIQDEPFPHPLEPEPGTPAQPGPGKPSDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVLLVLSAPFLRCIPAPGAGATGGSGSTAAQPNPAVFIFEHKAQHISRFIHNSQDLTYFAYLIKAQPDDPESQMACHVFRAADPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVTVTHKKAPSSLIDDCIEKFSLHEQQRLRLQSEPRAGDSGEDQAGSEARTPACPVDVLSEEGDGVADTHPVFPAAPSQPGPSSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVLQRKVHENSQKPQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESSEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKAVNDQEENELVILHLRQLCEAKQKTHVHIGEGPLGANRMRGRLGSVDSFERSNSVASEKDYSPGDSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGKAHGVRSPLLRQSSSEQCSDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPMRKSPSAMQQDGLDRSELLPLSPLAPTMEEEPLMIFMSDEDDPEKGEERNKSEELRCLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLTIWDKKLLNCRAKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSAQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSNQETLIMECENFENIVEFLKITLPDMNSSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYACEDSEPIEKLERANSQLKRQNMDLLEKLQIAHAKIQTLESNLENLLTRETKMKSLIRTLEQEKTAYQKAVEQIWKLLPADILANCEPLLRDLNCNPNNKAKTGNKP", "length": 1196, "header": "tr|A0AAA9TV94-1|A0AAA9TV94_BOVIN Computationally mapped isoform of TBC1 domain family member 4 OS=Bos taurus OX=9913 GN=TBC1D4 PE=4 SV=1 CANONICAL=A0AAA9SG49-1" }, "locus": { "chromosome": "12", "start_pos": 50540017, "end_pos": 50332402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099668.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099668.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102540.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102540.1" } ] } }, { "isoform_ac": "E1BPA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49/entry#E1BPA1-1", "sequence": { "sequence": "MEPPSCIQDEPFPHPLEPEPGTPAQPGPGKPSDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVLLVLSAPFLRCIPAPGAGATGGSGSTAAQPNPAVFIFEHKAQHISRFIHNSQDLTYFAYLIKAQPDDPESQMACHVFRAADPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVTVTHKKAPSSLIDDCIEKFSLHEQQRLRLQSEPRAGDSGEDQAGSEARTPACPVDVLSEEGDGVADTHPVFPAAPSQPGPSSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVLQRKVHENSQKPQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESSEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKAVNDQEENELVILHLRQLCEAKQKTHVHIGEGPLTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSVASEKDYSPGDSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGKAHGVRSPLLRQSSSEQCSILPPARRMHKECNSSSSLPSLHTSFSAPSFTAPPFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPMRKSPSAMQQDGLDRSELLPLSPLAPTMEEEPLMIFMSDEDDPEKGEERNKSEELRCLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLTIWDKKLLNCRAKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSAQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSNQETLIMECENFENIVEFLKITLPDMNSSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYACEDSEPIEKLERANSQLKRQNMDLLEKLQIAHAKIQTLESNLENLLTRETKMKSLIRTLEQEKTAYQKAVEQIWKLLPADILANCEPLLRDLNCNPNNKAKTGNKP", "length": 1299, "header": "tr|E1BPA1-1|E1BPA1_BOVIN Computationally mapped isoform of TBC1 domain family member 4 OS=Bos taurus OX=9913 GN=TBC1D4 PE=4 SV=2 CANONICAL=A0AAA9SG49-1" }, "locus": { "chromosome": "12", "start_pos": 50540017, "end_pos": 50332402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007574.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007574.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007574.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007574.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 22, "start_aa": "Thr", "end_pos": 22, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 615, "start_aa": "Thr", "end_pos": 615, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr615", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 705, "start_aa": "Thr", "end_pos": 705, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr705", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534649", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534649", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z881-1", "protein_name": "TBC1 domain family member 4", "gene_name": "Tbc1d4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESPSCIQDEPFPHPLEPEPIALAQPGATKPGDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSLKPEAGGCGAPAAREVLLVLSAPFLRCVPAPGVGVGGGAGSGAVQPNTGVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRLKLQGERGGDPGDGDEMGVLEAESPVSPDDGLPEKPDGLVNCPRALPSLASLPALASQPALASSRVCFPERILEDCGFDEQQEFRSRCSSVTGVMQKKVHENNQKTQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESLEPGLSQYICYVFQCANESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQKTHVHIGEGQAIISNSTIPENSTSGGRFKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDFSPGGSPPGTPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSSRRKLNLQDGKAHGLRSPLLRQNSSEQCSDGEGRKRTSSTCSNESLSAGGTPVTPRRISWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPLVIFLSGDEDTEKVEEKKKSKEIKSLWKKAIHQQILLLRMEKENQKLEARRDELQSRKVKLDYEEVGTCQKEVLIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTQPYFSVQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSSQEALVMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDELLESSYACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMKALIRTLEQDKMAYQKTVEQIRKLLPADALANCELLLKDLSYPTNDKAKAGNKP", "length": 1245 }, "evidence": [ { "id": "A0AAA9SG49", "url": "https://omabrowser.org/oma/group/A0AAA9SG49/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1JJ52-1", "protein_name": "Pollux, isoform C", "gene_name": "plx", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKTRLVSLTFRGSASVDPRYSASMLPWTINDIRSTESYTKLSVGIENGILESYNSDFELQFSHPLKHIVGMCRIIHKPQAKSIGNGFLQLKSSAGQTSSSSAVASSMGGAASSSLTGNGLRHTLTASTSYGSLSSSAACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTPLSPPSTASNSSGGSIFSRMGYRTTPPALSPLAQRQSYGVAITTAPCPQHMEEVAPATTMAVMPQEDVEEPQPMHPLSMVGGDVNVRFKGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAVRVAPVPVELAPPAATATTGRS", "length": 1572 }, "evidence": [ { "id": "A0AAA9SG49", "url": "https://omabrowser.org/oma/group/A0AAA9SG49/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O60343-1", "protein_name": "TBC1 domain family member 4", "gene_name": "TBC1D4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP", "length": 1298 }, "evidence": [ { "id": "A0AAA9SG49", "url": "https://omabrowser.org/oma/group/A0AAA9SG49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BYJ6-1", "protein_name": "TBC1 domain family member 4", "gene_name": "Tbc1d4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESPSCIQDEPFPHPLEPEPSAPAQPGATKPGDKRFRLWYVGGSCLDRRTTLPMLPWLMAEIRRRSQKPDAGGCGAPAAREVILVLSAPFLRCVPAPGAGVGGGAGSGAVQPNTGVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKAAMKEDSKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRLKLQGERGGDPGDEMGVLEVESPVSPDDSLPEKADGTVNSPRALPSLASLPALASQPALASSRVCFPERILEDCGFDEQQEFRSRCSSVTGVMQKKVHENNQKTQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCANESLVDEVMLTLKQAFSTAAALQSAKTQIKLCETCPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQRTHVHIGEGPAIISNSTIPENVTSGGRFKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLGSMDSFERANSLASEKDFSPGDSPPGTPPASPLSSAWHAFPEEDSDSPQFRRRAHTFSHPPSSSRRKLNLQDGKAHGLRSPLLRQSSSEQCSIVPSARRMYKESNSSCSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPLIIFLSGDEDTEKVEEKKKSKELKSLWKKAIHQQILLLRMEKENQKLEEARRDELQSRKVKLDYEEVGTCQKEILIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSSQEALIMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDELLESSYACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMKALIRTLEQDKMAYQKTVEQIRKLLPADALANCELLLKDLTHPTNDKAKAGNKP", "length": 1307 }, "evidence": [ { "id": "A0AAA9SG49", "url": "https://omabrowser.org/oma/group/A0AAA9SG49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SG49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1090, "end_pos": 1092, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" }, { "start_pos": 549, "end_pos": 551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 694, "end_pos": 696, "annotation": "n_glycosylation_sequon" }, { "start_pos": 772, "end_pos": 774, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" }, { "id": "PS01179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PID", "eco_id": "ECO_0000259", "start_pos": 368, "end_pos": 440, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG49" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 856, "end_pos": 1050, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 22, 615, 705 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1090, "end_pos": 1092 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 543, "end_pos": 545 }, { "start_pos": 549, "end_pos": 551 }, { "start_pos": 694, "end_pos": 696 }, { "start_pos": 772, "end_pos": 774 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SI10-1", "uniprot_ac": "A0AAA9SI10", "uniprot_id": "A0AAA9SI10_BOVIN", "mass": { "chemical_mass": 41635.0, "monoisotopic_mass": 41635.0 }, "refseq": {}, "gene_names": [ { "name": "LDAH", "type": "recommended", "evidence": [ { "id": "A0AAA9SI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ] } ], "protein_names": [ { "name": "Lipid droplet-associated hydrolase", "type": "recommended", "evidence": [ { "id": "A0AAA9SI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.13", "type": "synonym", "evidence": [ { "id": "A0AAA9SI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#names_and_taxonomy" } ] }, { "name": "Lipid droplet-associated serine hydrolase", "type": "synonym", "evidence": [ { "id": "A0AAA9SI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LDAH", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10", "locus": { "chromosome": "11", "start_pos": 78189172, "end_pos": 78103037, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031014", "url": "https://www.ensembl.org/id/ENSBTAG00000031014" } ] } } ], "crossref": [ { "id": "A0AAA9SI10", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SI10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031014", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031014", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WVPVSYY", "url": "https://omabrowser.org/oma/group/WVPVSYY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BNE1", "url": "https://www.orthodb.org/?gene=E1BNE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13390:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13390:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "36403", "url": "https://www.rhea-db.org/rhea/36403", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZF3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4K4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4K4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLB2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLB2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNE1", "url": "https://www.uniprot.org/uniprotkb/E1BNE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNE1-1", "url": "https://www.uniprot.org/uniprotkb/E1BNE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RWV4", "url": "https://www.uniprot.org/uniprotkb/F6RWV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RWV4-1", "url": "https://www.uniprot.org/uniprotkb/F6RWV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYHNWFAAAAAKSLQSCPTLCDLIDGSLPGSPARDSPEMDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPVIRSILLFPTIERMSESPKGRFATPLLCWLRYALYVPCYLLLKPWPEKIKFLAIRMVLQMMDIPREFLCMNMLEPFCLVNAAYLGSQEMREVVKRDDETIKEHLPKLIFYYGATDSWCPKEYYDDMKKDFPEGDIRLCEKKIPHAFVMSFFQEMADMVADWLKDDLSKM", "length": 364, "header": "tr|A0AAA9SI10-1|A0AAA9SI10_BOVIN Isoform 1 of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=1 CANONICAL=A0AAA9SI10-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#A0AAA9RZF3-1", "sequence": { "sequence": "MDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPLTLPTLGAKK", "length": 166, "header": "tr|A0AAA9RZF3-1|A0AAA9SI10_BOVIN Computationally mapped isoform of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=2 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78174743, "end_pos": 78107602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109075.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109075.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076485.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076485.2" } ] } }, { "isoform_ac": "A0AAA9S4K4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#A0AAA9S4K4-1", "sequence": { "sequence": "MDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPVIRSILLFPTIERMSESPKGRFATPLLCWLRYALYVPCYLLLKPWPEKIKFLAIRMVLQMMDIPREFLCMNMLEPFCLVNAAYLGSQEMREVVKRDDETIKEHLPKAHGNSWCVLLPDGIRASLSVNRALKSFPARAHETLLSDHGGQRWEDCLQMGLPLPPEGQPGATVWLGKGQRVLRNRDPPLLHTPPPA", "length": 349, "header": "tr|A0AAA9S4K4-1|A0AAA9SI10_BOVIN Computationally mapped isoform of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=2 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78180149, "end_pos": 78107602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110517.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110517.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080868.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080868.2" } ] } }, { "isoform_ac": "A0AAA9SDQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#A0AAA9SDQ8-1", "sequence": { "sequence": "MKSTEELQGQDRPECKVNEMDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPVIRSILLFPTIERMSESPKGRFATPLLCWLRYALYVPCYLLLKPWPEKIKFLAIRMVLQMMDIPREFLCMNMLEPFCLVNAAYLGSQEMREVVKRDDETIKEHLPKLIFYYGATDSWCPKEYYDDMKKDFPEGDIRLCEKKIPHAFVMSFFQEMADMVADWLKDDLSKM", "length": 344, "header": "tr|A0AAA9SDQ8-1|A0AAA9SI10_BOVIN Computationally mapped isoform of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=1 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78188168, "end_pos": 78106755, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080500.1" } ] } }, { "isoform_ac": "A0AAA9SI10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#A0AAA9SI10-1", "sequence": { "sequence": "MAYHNWFAAAAAKSLQSCPTLCDLIDGSLPGSPARDSPEMDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPVIRSILLFPTIERMSESPKGRFATPLLCWLRYALYVPCYLLLKPWPEKIKFLAIRMVLQMMDIPREFLCMNMLEPFCLVNAAYLGSQEMREVVKRDDETIKEHLPKLIFYYGATDSWCPKEYYDDMKKDFPEGDIRLCEKKIPHAFVMSFFQEMADMVADWLKDDLSKM", "length": 364, "header": "tr|A0AAA9SI10-1|A0AAA9SI10_BOVIN Isoform 1 of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=1 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78188168, "end_pos": 78104714, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123410.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123410.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083382.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083382.1" } ] } }, { "isoform_ac": "A0ABI0NLB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#A0ABI0NLB2-1", "sequence": { "sequence": "MDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPVIRSILLFPTIERMSESPKGRFATPLLCWLRYALYVPCYLLLKPWPEKIKFLAIRMVLQMMDIPREFLCMNMLEPFCLVNAAYLGSQEMREVVKRDDETIKEHLPKLIFYYGATDSWCPKEYYDDMKKDFPEGDIRLCEKKIPHAFVMSFFQEMADMVADWLKDDLSKM", "length": 277, "header": "tr|A0ABI0NLB2-1|A0ABI0NLB2_BOVIN Computationally mapped isoform of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=1 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78188168, "end_pos": 78107602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138804.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138804.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105788.1" } ] } }, { "isoform_ac": "E1BNE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#E1BNE1-1", "sequence": { "sequence": "MDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEDPNAEEIKDIYGVRGQVEHKLAFLRTQVPKEMKLVVIGHSIGSYFSLEILKHAPELPVIRSILLFPTIERMSESPKGRFATPLLCWLRYALYVPCYLLLKPWPEKIKFLAIRMVLQMMDIPREFLCMNMLEPFCLVNAAYLGSQEMREVVKRDDETIKEHLPKLIFYYGATDSWCPKEYYDDMKKDFPEGDIRLCEKKIPHAFVMSFFQEMADMVADWLKDDLSKM", "length": 325, "header": "tr|E1BNE1-1|E1BNE1_BOVIN Computationally mapped isoform of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=2 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78188168, "end_pos": 78107602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060987.5", "url": "https://www.ensembl.org/id/ENSBTAT00000060987.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053561.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053561.2" } ] } }, { "isoform_ac": "F6RWV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10/entry#F6RWV4-1", "sequence": { "sequence": "MKSTEELQGQDRPECKVNEMDSEIKEEIPVHEEFILCCGVETQVLKCGPWTDLINNQSGTRPKLLIFIIPGNPGFSAMYVPFAKALYSATKRRFPVWIISHAGHALAPRGKKILKSSEGTEKNPKICMEPQKTPNRQNNLEEED", "length": 144, "header": "tr|F6RWV4-1|F6RWV4_BOVIN Computationally mapped isoform of Lipid droplet-associated hydrolase OS=Bos taurus OX=9913 GN=LDAH PE=3 SV=2 CANONICAL=A0AAA9SI10-1" }, "locus": { "chromosome": "11", "start_pos": 78123286, "end_pos": 78106755, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043900.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043900.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041435.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041435.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LZ95-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "Ldah", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDSKVQEEIPVHEEFFLCGGVETQIIKCGPWTNLFDEQSATKPKLLIFIIPGNPGFSPFYLPFSKTLYSLTKGRFPVWMISHAGFAMAPKDKILAGPDETNAQEIEDVYGLNGQIEHKLAFLRAHVPKDVKLILIGHSIGSYIALRLMKHVPELPVIHTFLLFPTIERMSETPNGRFATPLLCWFRYVLYAASYLVLKPCPEIIKSFITTKALQRLNFTCEIPVKDALQPFCLANAAYLGSQEMIHVRKRDDEIIKEHLPKLTFYYGKTDGWCPVKYYEDMKKDFPEGDIRLCEKGIAHAFVLGFNQEVAAIVADWMNNKLPKI", "length": 324 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1N977-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "LDAH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLGVAEPAKGEANMRSVSEEPVPLHEEFIYCCGAATHVLKCGPWKDLSKDESKNLPRLLFMIIPGNPGLAGYYRTFIKALYCGLNQQYPVWVVSHAGHCKPPSGMEMIEDTDIKELEDVFGLNGQVEHKLNFLKKNVSKDIKLVLIAHSIGCYITLEMMKRASELQVLRSVLLFPTIERMAQSPQGKLMTPLLCKLRYALYMPVYLLSFLPEGIKASLVRFALRGMKTCDESSITTSVNLFSVDCIANILYMASQEMMKVVERDSTTIKQNLKKLIFYYGTGDSWCPQNYYDEIKMDFPDGDIRLCEKGLRHAFVLDASKEMAAMITDWLRDDLTKL", "length": 337 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3L9Q4-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "LDAH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDSDIKEEIPVHEEFILCCGVETQVLKCGPWTDLINDQSANRPKLLIFIITGNPGFSAFYAPFAKALYSSTKGQFPVWVISHAGHAMAPKGKKILTTSDDPNAQEIKDIYGLRGQVEHKLAFLRTHVPKEMKLVVIGHSIGCYISLQILKHGPELPIIRCFLLFPTIERMSESPNGKITTPLVCWFRYALYIPVYLLLKPWPVNIKSLMVRMCLRMMNLQSPSEFSLLNMLEPSCLVNVAYLASQEMMEVVKRDNETIKEHLSKLTFYYGTKDAWCPKEYYEDMKRDFPEGDIRLCEKMMPHAFVLHFHREMAAMVAAWLKDDLSKVQH", "length": 329 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54LL8-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MELIEEIINLDEAIQGETRTEIIYTKSQTPSNIKIIVIAGNPGIESFYQEFVKVLNLSFNSKYDIYGVGHIGHCGKIENKTFSVEEQIKHKELFLEYLLKNKYGDKDRKDIKFILIGHSVGSYISLKVVSRFSEKFEFLSVVNLFPTFKNLYDGLSPFIKMVVMRESTRNGLSTFLHYIPSIVVSNVLKWILPSDESRIAVQSKINYYSALNILYMAYTETEDIKEIDDECHSVFNSRLNQLLFIYGQTDSYTPKSFYDEMKQLYPAGNIEYSSSYVPHAFVLHHSQEVALRVSEWLSLNILKN", "length": 304 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5HZX7-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "Ldah", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASEVEDGVPVHEEFFLCGGVETQIIKCGPWTNLFDKQGVSKPKHLIFVIPGNPGLSPFYVPFAKALYSLVKGHFPVWIISHAGFCLTPKDKKILTAPQEPNAQEIEDIYGLNGQIEHKIAFLRAHVPKDVKLIFIGHSVGSYIALHVMNRAPELPVVHTFLLFPTIERMSESPNGKFATPFLCRFRYMLYAASYLIFKPCPEMIKSFIVQKVLEKMSFKSELRLTDLLQPFCLANAAYLGGQEMIHVVKRDDGIIKELLPKLTFYYGKTDGWCPVNYYEDMKRDFPEANLHLCEKGIPHAFVLGFSQEMAAMVADWINNRLPKK", "length": 325 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BVA5-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "Ldah", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASEVEEQIPVREEFFLCGGVETKIIKCGPWTNLFEKQDVSKPKQLIFIIPGNPGYSAFYVPFAKALYTLMKSRFPVWIISHAGFSVTPKDKKVLAAPQEESNAQKIEDVYGLNGQIEHKIAFLRAHVPKDVKLILIGHSVGTYMTLHVMKRVLELPVAHAFLLFPTIERMSESPNGKFATPFLCQFRYLLYATSYLLFKPCPEVIKSFIIQKLMGQMNIKLELPLTDILQPFCLANAAYLGSQEMVQIVKRDDDIIKEFLPKLKFYYGKTDGWCPVKYYEDMKKDFPEGNIYLCEKGIPHAFVLDFSQEMATIVAEWINNRPPRK", "length": 326 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6V9-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "LDAH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSELKEEIPVHEEFILCGGAETQVLKCGPWTDLFHDQSVKRPKLLIFIIPGNPGFSAFYVPFAKALYSLTNRRFPVWTISHAGHALAPKDKKILTTSEDSNAQEIKDIYGLNGQIEHKLAFLRTHVPKDMKLVLIGHSIGSYFTLQMLKRVPELPVIRAFLLFPTIERMSESPNGRIATPLLCWFRYVLYVTGYLLLKPCPETIKSLLIRRGLQVMNLENEFSPLNILEPFCLANAAYLGGQEMMEVVKRDDETIKEHLCKLTFYYGTIDPWCPKEYYEDIKKDFPEGDIRLCEKNIPHAFITHFNQEMADMIADSLKDDLSKM", "length": 325 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W0H3-1", "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "sturkopf", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQEAYVNINSIPTHIFTWGRWIEETITEKEIVICITGNPGLPGFYTEFAGTLQKELGDLPVWVIGHAGHDDPPEASIREVPQLSGNEELFNLDGQIRHKIAFIEKYVPSDVKIHLIGHSIGAWMILQLLENERIRSRIQKCYMLFPTVERMMESPNGWVFTKVAMPLYSVFGYIFFSFFNFLPVWLRLMLIQIYFLIFSIPRQFLGTALKYSKPSVAEKVVFLADDEMARVRGIQREIVEQNLDLLKFYYGTTDGWVPISYYDQLKKDYPKVDAQLDTKKIDHAFVLRHSQPMAVIVRDMIQQHRRV", "length": 307 }, "evidence": [ { "id": "A0AAA9SI10", "url": "https://omabrowser.org/oma/group/A0AAA9SI10/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sterol ester esterase activity", "id": "GO:0004771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004771", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "lipid storage", "id": "GO:0019915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" }, { "name": "intracellular triglyceride homeostasis", "id": "GO:0035356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035356", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" }, { "name": "lipid droplet fusion", "id": "GO:0160077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160077", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" }, { "name": "lipid droplet organization", "id": "GO:0034389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034389", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36403", "name": "", "equation": "a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SI10-1", "Q1JQE6-1" ], "evidence": [ { "id": "36403", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36403" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SI10", "gene_name": "LDAH", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = cholesterol + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9SI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "A0AAA9SI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI10" } ] } ] }, { "uniprot_ac": "Q1JQE6", "gene_name": "NCEH1", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q1JQE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE6" } ] }, { "ec_number": "3.1.1.71", "activity": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = a 1-O-alkyl-sn-glycerol + acetate + H(+).", "evidence": [ { "id": "Q1JQE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQE6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.13", "ec_name": "a cholesterol ester + H2O = cholesterol + a fatty acid + H(+).", "evidence": [ { "id": "3.1.1.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13" }, { "id": "3.1.1.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.13" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SGT2-1", "uniprot_ac": "A0AAA9SGT2", "uniprot_id": "A0AAA9SGT2_BOVIN", "mass": { "chemical_mass": 29675.0, "monoisotopic_mass": 29675.0 }, "refseq": {}, "gene_names": [ { "name": "ELP6", "type": "recommended", "evidence": [ { "id": "A0AAA9SGT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ] } ], "protein_names": [ { "name": "Elongator complex protein 6", "type": "recommended", "evidence": [ { "id": "A0AAA9SGT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2/entry#names_and_taxonomy" } ] }, { "name": "Protein TMEM103", "type": "synonym", "evidence": [ { "id": "A0AAA9SGT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Involved in cell migration.", "evidence": [ { "database": "UniProtKB", "id": "E1BNP5", "url": "https://www.uniprot.org/uniprotkb/E1BNP5#function" }, { "database": "UniProtKB", "id": "ARBA00059616", "url": "https://www.uniprot.org/uniprotkb/ARBA00059616#function" }, { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2", "locus": { "chromosome": "22", "start_pos": 52157228, "end_pos": 52133185, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011478", "url": "https://www.ensembl.org/id/ENSBTAG00000011478" } ] } } ], "crossref": [ { "id": "A0AAA9SGT2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SGT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011478", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011478", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19495", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19495", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR018627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BNP5", "url": "https://www.orthodb.org/?gene=E1BNP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16184:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16184:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNP5", "url": "https://www.uniprot.org/uniprotkb/E1BNP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BNP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPELNNLLNTTPEGAEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNMVGQKLGVSLTTARERGQLVVLEGLKSAVDIFFRPQEEPHPLQFLREANAGDLQPLYAFVRDALEPVDCGEAAWRCPVLLVDDLSVLLSLGVGPVAVLDFVHYCRATVCREWKGNVVALVHDSGDAEDEESDVLLNGLSHQSHLILRAEGLATGFCKDVHGQLRILWRRPLQPTTPRDRSLTYQYKIQDKSIFCCEPSSEPYSL", "length": 266, "header": "tr|A0AAA9SGT2-1|A0AAA9SGT2_BOVIN Isoform 1 of Elongator complex protein 6 OS=Bos taurus OX=9913 GN=ELP6 PE=3 SV=1 CANONICAL=A0AAA9SGT2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2/entry#A0AAA9SGT2-1", "sequence": { "sequence": "MFPELNNLLNTTPEGAEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNMVGQKLGVSLTTARERGQLVVLEGLKSAVDIFFRPQEEPHPLQFLREANAGDLQPLYAFVRDALEPVDCGEAAWRCPVLLVDDLSVLLSLGVGPVAVLDFVHYCRATVCREWKGNVVALVHDSGDAEDEESDVLLNGLSHQSHLILRAEGLATGFCKDVHGQLRILWRRPLQPTTPRDRSLTYQYKIQDKSIFCCEPSSEPYSL", "length": 266, "header": "tr|A0AAA9SGT2-1|A0AAA9SGT2_BOVIN Isoform 1 of Elongator complex protein 6 OS=Bos taurus OX=9913 GN=ELP6 PE=3 SV=1 CANONICAL=A0AAA9SGT2-1" }, "locus": { "chromosome": "22", "start_pos": 52156757, "end_pos": 52137257, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110578.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110578.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083094.1" } ] } }, { "isoform_ac": "E1BNP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2/entry#E1BNP5-1", "sequence": { "sequence": "MFPELNNLLNTTPEGAEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNMVGQKLGVSLTTARERGQLVVLEGLKSAVDIFFRPQEEPHPLQFLREANAGDLQPLYAFVRDALEPVDCGEAAWRCPVLLVDDLSVLLSLGVGPVAVLDFVHYCRATVCREWKGNVVALVHDSGDAEDEESDVLLNGLSHQSHLILRAEGLATGFCKDVHGQVRGALAHWELLASSVRPTAPGQCRARAAEDPVEKTTAAHHPPGSKPHVPVQDTGQECILFRQRNVSCCSVT", "length": 295, "header": "tr|E1BNP5-1|E1BNP5_BOVIN Computationally mapped isoform of Elongator complex protein 6 OS=Bos taurus OX=9913 GN=ELP6 PE=3 SV=2 CANONICAL=A0AAA9SGT2-1" }, "locus": { "chromosome": "22", "start_pos": 52149403, "end_pos": 52137257, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015255.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015255.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015255.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015255.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "pmid": "" }, { "name": "elongator holoenzyme complex", "id": "GO:0033588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033588", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA wobble uridine modification", "id": "GO:0002098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SGT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLM2-1", "uniprot_ac": "A0AAA9SLM2", "uniprot_id": "A0AAA9SLM2_BOVIN", "mass": { "chemical_mass": 37246.0, "monoisotopic_mass": 37246.0 }, "refseq": {}, "gene_names": [ { "name": "PIGP", "type": "recommended", "evidence": [ { "id": "A0AAA9SLM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol glycan anchor biosynthesis class P", "type": "synonym", "evidence": [ { "id": "A0AAA9SLM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SDA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA9#function" }, { "database": "UniProtKB", "id": "PIRNR008765", "url": "https://www.uniprot.org/uniprotkb/PIRNR008765#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLM2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46346:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46346:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08510", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08510", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VGHDCRRRGHARGEGWGGGEHPKRGAVTPRRRGHPHSRGVHARAGKNRHRHKGAARADISRVHARSGRRTPTRLAGVSPTHRRRRGRVGGLGTRTHTRASPTFAQEPRRTPTCRTGKSDKKDTPTGADDSGHTHIHTPRTGTIHPSYTHYRHHSQRRGATRTHPHSPHTPGGGVEGLSPRPSRLLRDKLTHPAAPPRASISKATGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITIVIGYVLLFGINMMSTSPLDSIHNITDNYAKNQQHKKDQEEAIPALRDIPISEVNQMFFLEAK", "length": 334, "header": "tr|A0AAA9SLM2-1|A0AAA9SLM2_BOVIN Isoform 1 of Phosphatidylinositol glycan anchor biosynthesis class P OS=Bos taurus OX=9913 GN=PIGP PE=4 SV=1 CANONICAL=A0AAA9SLM2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2/entry#A0AAA9SDA9-1", "sequence": { "sequence": "IVKMSGSLTDNLFLFSPHSISKATGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITIVIGYVLLFGINMMSTSPLDSIHNITDNYAKNQQHKKDQEEAIPALRDIPISEVNQMFFLEAKLYTKNL", "length": 160, "header": "tr|A0AAA9SDA9-1|A0AAA9SLM2_BOVIN Computationally mapped isoform of Phosphatidylinositol glycan anchor biosynthesis class P OS=Bos taurus OX=9913 GN=PIGP PE=4 SV=1 CANONICAL=A0AAA9SLM2-1" }, "locus": { "chromosome": "1", "start_pos": 149317302, "end_pos": 149305128, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129918.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129918.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080310.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080310.1" } ] } }, { "isoform_ac": "A0AAA9SLM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2/entry#A0AAA9SLM2-1", "sequence": { "sequence": "VGHDCRRRGHARGEGWGGGEHPKRGAVTPRRRGHPHSRGVHARAGKNRHRHKGAARADISRVHARSGRRTPTRLAGVSPTHRRRRGRVGGLGTRTHTRASPTFAQEPRRTPTCRTGKSDKKDTPTGADDSGHTHIHTPRTGTIHPSYTHYRHHSQRRGATRTHPHSPHTPGGGVEGLSPRPSRLLRDKLTHPAAPPRASISKATGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITIVIGYVLLFGINMMSTSPLDSIHNITDNYAKNQQHKKDQEEAIPALRDIPISEVNQMFFLEAK", "length": 334, "header": "tr|A0AAA9SLM2-1|A0AAA9SLM2_BOVIN Isoform 1 of Phosphatidylinositol glycan anchor biosynthesis class P OS=Bos taurus OX=9913 GN=PIGP PE=4 SV=1 CANONICAL=A0AAA9SLM2-1" }, "locus": { "chromosome": "1", "start_pos": 149318715, "end_pos": 149305149, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084851.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084851.1" } ] } }, { "isoform_ac": "A0AAA9T3M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2/entry#A0AAA9T3M5-1", "sequence": { "sequence": "MRRQGPVLGVEAQAGGRLGAGPPIRPCPFFPVLIEAKPAELGWRSVPPPTPHCRNISKATGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITIVIGYVLLFGINMMSTSPLDSIHNITDNYAKNQQHKKDQEEAIPALRDIPISEVNQMFFLEAK", "length": 190, "header": "tr|A0AAA9T3M5-1|A0AAA9T3M5_BOVIN Computationally mapped isoform of Phosphatidylinositol glycan anchor biosynthesis class P OS=Bos taurus OX=9913 GN=PIGP PE=4 SV=1 CANONICAL=A0AAA9SLM2-1" }, "locus": { "chromosome": "1", "start_pos": 149317646, "end_pos": 149305149, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121143.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121143.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091086.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 28, "start_aa": "Thr", "end_pos": 28, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol N-acetylglucosaminyltransferase activity", "id": "GO:0017176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM2" }, { "id": "PF08510", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08510" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIG-P", "eco_id": "ECO_0000259", "start_pos": 218, "end_pos": 330, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 28 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 295, "end_pos": 297 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJI1-1", "uniprot_ac": "A0AAA9SJI1", "uniprot_id": "A0AAA9SJI1_BOVIN", "mass": { "chemical_mass": 39638.0, "monoisotopic_mass": 39638.0 }, "refseq": { "ac": "XP_005226088", "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226088" }, "gene_names": [ { "name": "TUSC3", "type": "recommended", "evidence": [ { "id": "A0AAA9SJI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ] }, { "name": "TUSC3", "type": "synonym", "evidence": [ { "id": "XP_005226088", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226088" } ] } ], "protein_names": [ { "name": "Tumor suppressor candidate 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SJI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#names_and_taxonomy" } ] }, { "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_005226088", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226088" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TUSC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1", "locus": { "chromosome": "27", "start_pos": 21352503, "end_pos": 21570464, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009191", "url": "https://www.ensembl.org/id/ENSBTAG00000009191" } ] } } ], "crossref": [ { "id": "A0AAA9SJI1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009191", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009191", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615007", "url": "https://www.ncbi.nlm.nih.gov/gene/615007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFB7", "url": "https://www.orthodb.org/?gene=A0A3Q1LFB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MFE0", "url": "https://www.orthodb.org/?gene=F1MFE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12692", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12692", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12692:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12692:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5223345", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005226088", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226088", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFB7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFE0", "url": "https://www.uniprot.org/uniprotkb/F1MFE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFE0-1", "url": "https://www.uniprot.org/uniprotkb/F1MFE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDLDFE", "length": 348, "header": "tr|A0AAA9SJI1-1|A0AAA9SJI1_BOVIN Isoform 1 of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0A3Q1LFB7-1", "sequence": { "sequence": "MKRKARIRSPLLGKTEILFTEMGNKRKNLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK", "length": 328, "header": "tr|A0A3Q1LFB7-1|A0AAA9SJI1_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=2 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21553759, "end_pos": 21353053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087352.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087352.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056828.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056828.2" } ] } }, { "isoform_ac": "A0AAA9SJI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0AAA9SJI1-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDLDFE", "length": 348, "header": "tr|A0AAA9SJI1-1|A0AAA9SJI1_BOVIN Isoform 1 of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21356905, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125369.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125369.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083966.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083966.1" } ] } }, { "isoform_ac": "A0AAA9SLZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0AAA9SLZ5-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVMLLSPWGWFF", "length": 276, "header": "tr|A0AAA9SLZ5-1|A0AAA9SLZ5_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21373201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084915.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084915.1" } ] } }, { "isoform_ac": "A0AAA9SP48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0AAA9SP48-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRSNCSPQGVPEKSSALRSTGQRLSESLKFSISCHKSSHN", "length": 350, "header": "tr|A0AAA9SP48-1|A0AAA9SJI1_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21372349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099997.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099997.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087147.1" } ] } }, { "isoform_ac": "A0AAA9STT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0AAA9STT9-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRTF", "length": 314, "header": "tr|A0AAA9STT9-1|A0AAA9STT9_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21353061, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093279.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093279.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089838.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089838.1" } ] } }, { "isoform_ac": "A0AAA9SW16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0AAA9SW16-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSKEFSFFFSFLIK", "length": 355, "header": "tr|A0AAA9SW16-1|A0AAA9SW16_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21353053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101519.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101519.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088411.1" } ] } }, { "isoform_ac": "A0AAA9TF21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#A0AAA9TF21-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQVQFVAESHIILVLTF", "length": 289, "header": "tr|A0AAA9TF21-1|A0AAA9TF21_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=1 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21382708, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124190.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124190.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094743.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094743.1" } ] } }, { "isoform_ac": "F1MFE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1/entry#F1MFE0-1", "sequence": { "sequence": "MGARGAPSRRRQAGRRPRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSVFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRLANEEYQILANSWRYSSAFCNKLFFSKVDYDEGTDIFQQLNINSAPTFMHFPPKGRPKRADTFDLQRIGFGAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLSYIHGSSQVQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK", "length": 317, "header": "tr|F1MFE0-1|F1MFE0_BOVIN Computationally mapped isoform of Tumor suppressor candidate 3 OS=Bos taurus OX=9913 GN=TUSC3 PE=3 SV=3 CANONICAL=A0AAA9SJI1-1" }, "locus": { "chromosome": "27", "start_pos": 21570292, "end_pos": 21353053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012110.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012110.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012110.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012110.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5223345", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5223345", "resource": "Reactome", "description": "Miscellaneous transport and binding events" }, { "id": "R-BTA-9931295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "resource": "Reactome", "description": "PD-L1(CD274) glycosylation and translocation to plasma membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "oligosaccharyltransferase complex", "id": "GO:0008250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "magnesium ion transmembrane transporter activity", "id": "GO:0015095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015095", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cognition", "id": "GO:0050890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050890", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ], "pmid": "" }, { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ], "pmid": "" }, { "name": "magnesium ion transmembrane transport", "id": "GO:1903830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903830", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 227, "end_pos": 229 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SL25-1", "uniprot_ac": "A0AAA9SL25", "uniprot_id": "A0AAA9SL25_BOVIN", "mass": { "chemical_mass": 58396.0, "monoisotopic_mass": 58396.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD42", "type": "recommended", "evidence": [ { "id": "A0AAA9SL25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 42", "type": "synonym", "evidence": [ { "id": "A0AAA9SL25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25", "locus": { "chromosome": "29", "start_pos": 12411684, "end_pos": 12472797, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001391", "url": "https://www.ensembl.org/id/ENSBTAG00000001391" } ] } } ], "crossref": [ { "id": "A0AAA9SL25", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SL25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001391", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001391", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24201:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24201:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LHW2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHW2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2X0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2X0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP31", "url": "https://www.uniprot.org/uniprotkb/E1BP31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP31-1", "url": "https://www.uniprot.org/uniprotkb/E1BP31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLFNSYSWKLLPNQDSTLCTGARKKVHFGSIHDAVRAGDVKQLSEIVQRGASINEVDVLHKFTPLHWAAHSGSLECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETLAFPGHVAAFKGDLEMLKKLIEDGVININERDNNGSTLMHKAAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARVRAFKKIVELRHLLEIAESNYKHLGGITEEDIKQKKEQLESAKTIKELQGQLEYERLRREKLECQLDEYRVEVDQLKEMLEKTQVPNFVAVEDDISCELSKEKRRVKKKVSSGGVFVKRY", "length": 519, "header": "tr|A0AAA9SL25-1|A0AAA9SL25_BOVIN Isoform 1 of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=1 CANONICAL=A0AAA9SL25-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LHW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#A0A3Q1LHW2-1", "sequence": { "sequence": "MPGVSDSGPSTSSTETATPLGARKKVHFGSIHDAVRAGDVKQLSEIVQRGASINEVDVLHKFTPLHWAAHSGSLECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETLAFPGHVAAFKGDLEMLKKLIEDGVININERDNNGSTLMHKAAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARVRAFKKIVELRHLLEIAESNYKHLGGITEEDIKQKKEQLESAKTIKELQGQLEYERLRREKLECQLDEYRVEVDQLKEMLEKTQVPNFVAVEDDISCELSKEKRRVKKKVSSGGVFVKS", "length": 518, "header": "tr|A0A3Q1LHW2-1|A0AAA9SL25_BOVIN Computationally mapped isoform of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=2 CANONICAL=A0AAA9SL25-1" }, "locus": { "chromosome": "29", "start_pos": 12472521, "end_pos": 12417325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077719.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077719.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058443.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058443.2" } ] } }, { "isoform_ac": "A0AAA9SL25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#A0AAA9SL25-1", "sequence": { "sequence": "MLFNSYSWKLLPNQDSTLCTGARKKVHFGSIHDAVRAGDVKQLSEIVQRGASINEVDVLHKFTPLHWAAHSGSLECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETLAFPGHVAAFKGDLEMLKKLIEDGVININERDNNGSTLMHKAAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARVRAFKKIVELRHLLEIAESNYKHLGGITEEDIKQKKEQLESAKTIKELQGQLEYERLRREKLECQLDEYRVEVDQLKEMLEKTQVPNFVAVEDDISCELSKEKRRVKKKVSSGGVFVKRY", "length": 519, "header": "tr|A0AAA9SL25-1|A0AAA9SL25_BOVIN Isoform 1 of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=1 CANONICAL=A0AAA9SL25-1" }, "locus": { "chromosome": "29", "start_pos": 12470442, "end_pos": 12418196, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116489.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116489.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087079.1" } ] } }, { "isoform_ac": "A0AAA9SNI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#A0AAA9SNI7-1", "sequence": { "sequence": "MPGVSDSGPSTSSTETATPLGARKKVHFGSIHDAVRAGDVKQLSEIVQRGASINEVDVLHKFTPLHWAAHSGSLECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETLAFPGHVAAFKGDLEMLKKLIEDGVININERDNNGSTLMHKAAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARVRAFKKIVELRHLLEIAESNYKHLGGITEEDIKQKKEQLESAKTIKELQGQLEYERLRREKLECQLDEYRVEVDQLKEMLEKTQVPNFVAVEDDISCELSKEKRRVKKKVSSGGVFVKRKYWDSSSEWLEGQDHGAHFLPQIHQKMHQHVEQFSQNTYKCLQIS", "length": 563, "header": "tr|A0AAA9SNI7-1|A0AAA9SNI7_BOVIN Computationally mapped isoform of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=1 CANONICAL=A0AAA9SL25-1" }, "locus": { "chromosome": "29", "start_pos": 12472521, "end_pos": 12412713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125292.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125292.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086893.1" } ] } }, { "isoform_ac": "A0AAA9TKE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#A0AAA9TKE1-1", "sequence": { "sequence": "MPGVSDSGPSTSSTETATPLGARKKVHFGSIHDAVRAGDVKQLSEIVQRGASINEVDVLHKFTPLHWAAHSGSLECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARVRAFKKIVELRHLLEIAESNYKHLGGITEEDIKQKKEQLESAKTIKELQGQLEYERLRREKLECQLDEYRVEVDQLKEMLEKTQVPNFVAVEDDISCELSKEKRRVKKKVSSGGVFVKRSHRTKAPIPT", "length": 486, "header": "tr|A0AAA9TKE1-1|A0AAA9TKE1_BOVIN Computationally mapped isoform of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=1 CANONICAL=A0AAA9SL25-1" }, "locus": { "chromosome": "29", "start_pos": 12472521, "end_pos": 12412688, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115141.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115141.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097402.1" } ] } }, { "isoform_ac": "A0ABI0P2X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#A0ABI0P2X0-1", "sequence": { "sequence": "MKCLTVRMDVVKTDDECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETLAFPGHVAAFKGDLEMLKKLIEDGVININERDNNGSTLMHKAAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARGLSKSCRASWSMNDYAERS", "length": 359, "header": "tr|A0ABI0P2X0-1|A0ABI0P2X0_BOVIN Computationally mapped isoform of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=1 CANONICAL=A0AAA9SL25-1" }, "locus": { "chromosome": "29", "start_pos": 12465433, "end_pos": 12423590, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143062.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143062.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105078.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105078.1" } ] } }, { "isoform_ac": "E1BP31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25/entry#E1BP31-1", "sequence": { "sequence": "MPGVSDSGPSTSSTETATPLGARKKVHFGSIHDAVRAGDVKQLSEIVQRGASINEVDVLHKFTPLHWAAHSGSLECLHWLLWHGADISQVTARGWTAAHISAIRGQDACMQALIINGANLAAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWKPVHYAAFHGRLGCLQLLVKWGCSVEDVDYNGNLPVHLAAMEGHLHCFKFLLSRMSSASQGLKAFNDNGENVLDLAQRFFKQNILQFIRGSEYEGNDPTDQETLAFPGHVAAFKGDLEMLKKLIEDGVININERDNNGSTLMHKAAGQGHIECLQWLIKMGADNNITNKAREKPSDVAKRFAHLAAVKLLEGLQKYDIDDANEINENDIRFFIRHGVEGSTDAKDDLGLSESDKTDARGLSKSCRASWSMNDYAERS", "length": 418, "header": "tr|E1BP31-1|A0AAA9SL25_BOVIN Computationally mapped isoform of Ankyrin repeat domain 42 OS=Bos taurus OX=9913 GN=ANKRD42 PE=4 SV=5 CANONICAL=A0AAA9SL25-1" }, "locus": { "chromosome": "29", "start_pos": 12472521, "end_pos": 12423590, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033977.7", "url": "https://www.ensembl.org/id/ENSBTAT00000033977.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033880.7", "url": "https://www.ensembl.org/id/ENSBTAP00000033880.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "NF-kappaB binding", "id": "GO:0051059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase inhibitor activity", "id": "GO:0004861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 326, "end_pos": 328 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKE0-1", "uniprot_ac": "A0AAA9SKE0", "uniprot_id": "A0AAA9SKE0_BOVIN", "mass": { "chemical_mass": 60030.0, "monoisotopic_mass": 60030.0 }, "refseq": {}, "gene_names": [ { "name": "MARCOL", "type": "recommended", "evidence": [ { "id": "A0AAA9SKE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0" } ] } ], "protein_names": [ { "name": "Kazal-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SKE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MARCOL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKE0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052607", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052607", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24637", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24637", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24637:SF421", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24637:SF421", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37456", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37456", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37456:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37456:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00050", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00050", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LKZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAFIFLPFMFLALFSVSSTQPLKTGSVFKLGDSPEPALILERENEANQQGGQKEFKRETGSNTQGKPGPLILQGQPRYSNQPGKPENFKQKERPGVFNQPGSLQANSGQSNQKGNPEASNEQGKPGSFSQQGKPGSSNHQGKPGSTSQQGEPGSSSQQGKPGSTSQPGKPGSSSQPGKPGSNSQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGKPGSSIQPGKPGSSGQQGKPGSSGQQGKPGSSSQPGKPGSSSQQGSPGSSSQQGSPGSSSQKGNPRLSRQQRKSKSFYNQEEGKTGVNPWNDNTIEIQTGHTSNKNPTRKTKCQPNYEPVCGSDGKTYGNHCAFNEAKRLSNGKLSLNHEGKC", "length": 598, "header": "tr|A0AAA9SKE0-1|A0AAA9SKE0_BOVIN Isoform 1 of Kazal-like domain-containing protein OS=Bos taurus OX=9913 GN=MARCOL PE=4 SV=1 CANONICAL=A0AAA9SKE0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0/entry#A0A3Q1LKZ8-1", "sequence": { "sequence": "MEAFIFLPFMFLALFSVSSTQPLKTGSVFKLGDSPEPALILERENEANQQGGQKEFKRETGSNTQGKPGPLILQGQPRYSNQPGKPENFKQKERPGVFNQPGSLQANSGQSNQKGNPEASNEQGKPGSFSQQGKPGSSNHQGKPGSTSQQGEPGSSSQQGKPGSTSQPGKPGSSSQPGKPGSNSQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGKPGSSIQPGKPGSSGQQGKPGSSGQQGKPGSSSQPGKPGSSSQQGSPGSSSQQGSPGSSSQKGNPRLSRQQRKSKSFYNQEEGKTGVNPWNDNTIEIQVE", "length": 545, "header": "tr|A0A3Q1LKZ8-1|A0AAA9SKE0_BOVIN Computationally mapped isoform of Kazal-like domain-containing protein OS=Bos taurus OX=9913 GN=MARCOL PE=4 SV=2 CANONICAL=A0AAA9SKE0-1" }, "locus": { "chromosome": "7", "start_pos": 59531955, "end_pos": 59522656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080140.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080140.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060408.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060408.2" } ] } }, { "isoform_ac": "A0AAA9SKE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0/entry#A0AAA9SKE0-1", "sequence": { "sequence": "MEAFIFLPFMFLALFSVSSTQPLKTGSVFKLGDSPEPALILERENEANQQGGQKEFKRETGSNTQGKPGPLILQGQPRYSNQPGKPENFKQKERPGVFNQPGSLQANSGQSNQKGNPEASNEQGKPGSFSQQGKPGSSNHQGKPGSTSQQGEPGSSSQQGKPGSTSQPGKPGSSSQPGKPGSNSQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSIQPGKPGSSSQQGEPGSNSQPGKPGSSSQQGEPGSSIQPGKPGSSIQPGKPGSSIQPGKPGKPGSSIQPGKPGSSGQQGKPGSSGQQGKPGSSSQPGKPGSSSQQGSPGSSSQQGSPGSSSQKGNPRLSRQQRKSKSFYNQEEGKTGVNPWNDNTIEIQTGHTSNKNPTRKTKCQPNYEPVCGSDGKTYGNHCAFNEAKRLSNGKLSLNHEGKC", "length": 598, "header": "tr|A0AAA9SKE0-1|A0AAA9SKE0_BOVIN Isoform 1 of Kazal-like domain-containing protein OS=Bos taurus OX=9913 GN=MARCOL PE=4 SV=1 CANONICAL=A0AAA9SKE0-1" }, "locus": { "chromosome": "7", "start_pos": 59531992, "end_pos": 59522656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106631.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106631.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085759.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKE0" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 558, "end_pos": 598, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMH1-1", "uniprot_ac": "A0AAA9SMH1", "uniprot_id": "A0AAA9SMH1_BOVIN", "mass": { "chemical_mass": 51483.0, "monoisotopic_mass": 51483.0 }, "refseq": { "ac": "NP_001192693", "name": "E3 ubiquitin-protein ligase TRIM15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192693" }, "gene_names": [ { "name": "TRIM15", "type": "recommended", "evidence": [ { "id": "A0AAA9SMH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ] }, { "name": "TRIM15", "type": "synonym", "evidence": [ { "id": "NP_001192693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192693" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM15", "type": "recommended", "evidence": [ { "id": "A0AAA9SMH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAA9SMH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase TRIM15", "type": "synonym", "evidence": [ { "id": "NP_001192693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192693" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1", "locus": { "chromosome": "23", "start_pos": 28802214, "end_pos": 28813725, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007532", "url": "https://www.ensembl.org/id/ENSBTAG00000007532" } ] } } ], "crossref": [ { "id": "A0AAA9SMH1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007532", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007532", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15826", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15826", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540074", "url": "https://www.ncbi.nlm.nih.gov/gene/540074", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540074", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540074", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDTKCRE", "url": "https://omabrowser.org/oma/group/EDTKCRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LN45", "url": "https://www.orthodb.org/?gene=A0A3Q1LN45", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MS12", "url": "https://www.orthodb.org/?gene=F1MS12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN45-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS12", "url": "https://www.uniprot.org/uniprotkb/F1MS12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS12-1", "url": "https://www.uniprot.org/uniprotkb/F1MS12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSTPSHKGATCSKCKGPLEDAVTAACGHAFCRLCLPPPSQMGAQPSGRVLLCALCEEEEPRETLLVPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPSHQAHVVGFLDEAIQPYRDRLRSRLEALSTERDEIDDMKSREDQKLQVLLTQIESKKQQVEAAFERLQQELGKQQRLLLARLTELERRIWKERDEYLSKLSEEVARLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDLHRKILTLPEMMRAFSENLVHHLETESGVVTLDPQTASRSLVLSEDRKSVRYTRQKQNLPDSPLRFEGLPVVLGSPGFSSGRHRWQVEVQLGDGGGCTVGVVGEEVRRKGEQGLSAEEGVWAVVLSHQQCWASTSPGTDLPLSDIPRHVGVALDYEAGRVALLDADTQAPIFTFTASFSGKVFPFFAVWKKGSCLTLKG", "length": 461, "header": "tr|A0AAA9SMH1-1|A0AAA9SMH1_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM15 OS=Bos taurus OX=9913 GN=TRIM15 PE=3 SV=1 CANONICAL=A0AAA9SMH1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1/entry#A0A3Q1LN45-1", "sequence": { "sequence": "MVPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPSHQAHVVGFLDEAIQPYRDRLRSRLEALSTERDEIDDMKSREDQKLQVLLTQIESKKQQVEAAFERLQQELGKQQRLLLARLTELERRIWKERDEYLSKLSEEVARLGAQVKELEEKCQQPASELLQDVRGRVLMCEMKTFVSPEAISPDLVKKIRDLHRKILTLPEMMRAFSENLVHHLETESGVVTLDPQTASRSLVLSEDRKSVRYTRQKQNLPDSPLRFEGLPVVLGSPGFSSGRHRWQVEVQLGDGGGCTVGVVGEEVRRKGEQGLSAEEGVWAVVLSHQQCWASTSPGTDLPLSDIPRHVGVALDYEAGRVALLDADTQAPIFTFTASFSGKVFPFFAVWKKGSCLTLKG", "length": 396, "header": "tr|A0A3Q1LN45-1|A0AAA9SMH1_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM15 OS=Bos taurus OX=9913 GN=TRIM15 PE=3 SV=3 CANONICAL=A0AAA9SMH1-1" }, "locus": { "chromosome": "23", "start_pos": 28813331, "end_pos": 28803218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081701.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081701.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061370.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061370.2" } ] } }, { "isoform_ac": "A0AAA9SMH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1/entry#A0AAA9SMH1-1", "sequence": { "sequence": "MPSTPSHKGATCSKCKGPLEDAVTAACGHAFCRLCLPPPSQMGAQPSGRVLLCALCEEEEPRETLLVPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPSHQAHVVGFLDEAIQPYRDRLRSRLEALSTERDEIDDMKSREDQKLQVLLTQIESKKQQVEAAFERLQQELGKQQRLLLARLTELERRIWKERDEYLSKLSEEVARLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDLHRKILTLPEMMRAFSENLVHHLETESGVVTLDPQTASRSLVLSEDRKSVRYTRQKQNLPDSPLRFEGLPVVLGSPGFSSGRHRWQVEVQLGDGGGCTVGVVGEEVRRKGEQGLSAEEGVWAVVLSHQQCWASTSPGTDLPLSDIPRHVGVALDYEAGRVALLDADTQAPIFTFTASFSGKVFPFFAVWKKGSCLTLKG", "length": 461, "header": "tr|A0AAA9SMH1-1|A0AAA9SMH1_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM15 OS=Bos taurus OX=9913 GN=TRIM15 PE=3 SV=1 CANONICAL=A0AAA9SMH1-1" }, "locus": { "chromosome": "23", "start_pos": 28813526, "end_pos": 28803218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108622.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108622.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085134.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085134.1" } ] } }, { "isoform_ac": "A0AAA9SX78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1/entry#A0AAA9SX78-1", "sequence": { "sequence": "MPSTPSHKGATCSKCKGPLEDAVTAACGHAFCRLCLPPPSQMGAQPSGRVLLCALCEEEEPRETLLVPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPSHQAHVVGFLDEAIQPYRDRLRSRLEALSTERDEIDDMKSREDQKLQVLLTQIESKKQQVEAAFERLQQELGKQQRLLLARLTELERRIWKERDEYLSKLSEEVARLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDLHRKILTLPEMMRAFSGVVTLDPQTASRSLVLSEDRKSVRYTRQKQNLPDSPLRFEGLPVVLGSPGFSSGRHRWQVEVQLGDGGGCTVGVVGEEVRRKGEQGLSAEEGVWAVVLSHQQCWASTSPGTDLPLSDIPRHVGVALDYEAGRVALLDADTQAPIFTFTASFSGKVFPFFAVWKKGSCLTLKG", "length": 450, "header": "tr|A0AAA9SX78-1|A0AAA9SX78_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM15 OS=Bos taurus OX=9913 GN=TRIM15 PE=3 SV=1 CANONICAL=A0AAA9SMH1-1" }, "locus": { "chromosome": "23", "start_pos": 28813526, "end_pos": 28803218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088824.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088824.1" } ] } }, { "isoform_ac": "F1MS12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1/entry#F1MS12-1", "sequence": { "sequence": "MPSTPSHKGATCSKCKGPLEDAVTAACGHAFCRLCLPPPSQMGAQPSGRVLLCALCEEEEPRETLLVPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPSHQAHVVGFLDEAIQPYRDRLRSRLEALSTERDEIDDMKSREDQKLQVLLTQIESKKQQVEAAFERLQQELGKQQRLLLARLTELERRIWKERDEYLSKLSEEVARLGAQVKELEEKCQQPASELLQNLTGYQLVCRCEMKTFVSPEAISPDLVKKIRDLHRKILTLPEMMRAFSAASSDVHAFLPIGVVTLDPQTASRSLVLSEDRKSVRYTRQKQNLPDSPLRFEGLPVVLGSPGFSSGRHRWQVEVQLGDGGGCTVGVVGEEVRRKGEQGLSAEEGVWAVVLSHQQCWASTSPGTDLPLSDIPRHVGVALDYEAGRVALLDADTQAPIFTFTASFSGKVFPFFAVWKKGS", "length": 458, "header": "tr|F1MS12-1|F1MS12_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM15 OS=Bos taurus OX=9913 GN=TRIM15 PE=3 SV=4 CANONICAL=A0AAA9SMH1-1" }, "locus": { "chromosome": "23", "start_pos": 28813526, "end_pos": 28803236, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012653.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012653.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012653.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012653.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:540074", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540074", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTL1-1", "protein_name": "Tripartite motif containing 15", "gene_name": "Trim15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLTRSLRGPHQVACTVCTRPLQDAVTIACGHAVCLLCLPRAPMGAQLLCPLCQGAEEEKIQTAVTPVSLGPLSETCCEEHGEKIYFFCKTDAELLCVFCREGPAHQAHTVGFLDEAIQPYRDRLRSRLEALRMERDKIEDRKCQEDQKLQEVLMQVESKKQQVEAAFERLKRELVDQRCLLLTRLEELEQQIWKEREEYITTVSQEVDRLGAQVEELEEKCQQPASELLQDARLNQSRYEMKTFVCPEAISSDLIKKIRNLHRKILCLPKMMRTFSENLMHHLETDSETEA", "length": 292 }, "evidence": [ { "id": "A0AAA9SMH1", "url": "https://omabrowser.org/oma/group/A0AAA9SMH1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9C019-1", "protein_name": "E3 ubiquitin-protein ligase TRIM15", "gene_name": "TRIM15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG", "length": 465 }, "evidence": [ { "id": "A0AAA9SMH1", "url": "https://omabrowser.org/oma/group/A0AAA9SMH1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9TSW0-1", "protein_name": "E3 ubiquitin-protein ligase TRIM15", "gene_name": "TRIM15", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPLTPSHKGAVCSDCQGRLEDAVTAACGHTFCRLCLPLPPQMGAQPSSRVLLCPVCQEKEQTEPVLVPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPSHQAHAVGFLDEAIQPYRDRLRGRLEALITERDEIEDMKSREDQKLQVLLAQIESKKRHVEATFERLQQELGEQQRLLLARLTELERQIWKERDKYISKLSEEVARLGTQVKELEEKCQQPASELLQDVRVNQSRCETKTFVSPEAISPDLVKKIRDLHRKILTLPEMLRAFSENLVHHLETDSGIVTLDPLTASPSLVLSEDRKSVRYTRQKQNLPDSPLRFEGLPVVLGSPGFSSGRHRWQVEVQLGEGGGCTVGVVGEEVRRKGEQGLSAEEGVWAVILSHQQCWASTSPGTDLPLSEIPRRVGVALDYEAGRVALLNAETRAPIFTFAASFSGKVFPFFAVWKKGSCLTLKG", "length": 461 }, "evidence": [ { "id": "A0AAA9SMH1", "url": "https://omabrowser.org/oma/group/A0AAA9SMH1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "molecular sequestering activity", "id": "GO:0140313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140313", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "suppression of viral release by host", "id": "GO:0044790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044790", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "negative regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "positive regulation of RIG-I signaling pathway", "id": "GO:1900246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "negative regulation of intracellular transport of viral material", "id": "GO:1901253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901253", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 122, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 272, "end_pos": 461, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH1" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 57, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 237, "end_pos": 239 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKN9-1", "uniprot_ac": "A0AAA9SKN9", "uniprot_id": "A0AAA9SKN9_BOVIN", "mass": { "chemical_mass": 119696.0, "monoisotopic_mass": 119696.0 }, "refseq": {}, "gene_names": [ { "name": "EFL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ] } ], "protein_names": [ { "name": "Elongation factor-like GTPase 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#names_and_taxonomy" } ] }, { "name": "Elongation factor Tu GTP-binding domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#names_and_taxonomy" } ] }, { "name": "Elongation factor-like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM42A", "type": "synonym", "evidence": [ { "id": "A0AAA9SKN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.", "evidence": [ { "database": "UniProtKB", "id": "E1BH79", "url": "https://www.uniprot.org/uniprotkb/E1BH79#function" }, { "database": "UniProtKB", "id": "ARBA00054932", "url": "https://www.uniprot.org/uniprotkb/ARBA00054932#function" }, { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9#function" }, { "database": "UniProtKB", "id": "A0AAA9TE99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE99#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9", "locus": { "chromosome": "21", "start_pos": 23940247, "end_pos": 24055255, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003410", "url": "https://www.ensembl.org/id/ENSBTAG00000003410" } ] } } ], "crossref": [ { "id": "A0AAA9SKN9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003410", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003410", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01681", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01681", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01885", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01885", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16261", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16261", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16268", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16268", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527607", "url": "https://www.ncbi.nlm.nih.gov/gene/527607", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035647", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035647", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527607", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527607", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FARCDIQ", "url": "https://omabrowser.org/oma/group/FARCDIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BH79", "url": "https://www.orthodb.org/?gene=E1BH79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42908", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42908", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42908:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42908:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LPM1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPM1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH79", "url": "https://www.uniprot.org/uniprotkb/E1BH79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BH79-1", "url": "https://www.uniprot.org/uniprotkb/E1BH79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLNSLDKMIQLQKNTANIRNICVLAHVDHGDKEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAEREAESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPDQGNVVFTSAIDGWGFGIEHFAKIYSQKTGIRKEVLLKTLWGDYYINTKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKTDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISQAVLAMVCQKLPSPLDITAERVEKLMCAGSQTFDSLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAERRERARRRHAEKLAAAQGQAPVEPTQDAGALEMSPQGEEPKGDEQGVESETPKPVSPEGSEQESFIAFARVFSGVARKGKRIFVLGPKYSPLEFLQQVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCTSPSCPPFIPLNFEATPIVRVAIEPKHPSEMPQLVKGMKLLNQADPCVQVFIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSNGLITMMTPNKLATLSVRALPLPEEVTQILEESSDLIRSMEQLTSSLNEGKNNPQMIHQKTQEKIWEFKGKLEHHLTGRKWRNTVDQIWSFGPRKCGPNILVNKSEDFHNSVWTGLDGKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQTASDLVKERQGEGDTRSGGDEQQELQDYGSEPFEKRASQRGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1070, "header": "tr|A0AAA9SKN9-1|A0AAA9SKN9_BOVIN Isoform 1 of Elongation factor-like GTPase 1 OS=Bos taurus OX=9913 GN=EFL1 PE=4 SV=1 CANONICAL=A0AAA9SKN9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#A0A3Q1LPM1-1", "sequence": { "sequence": "MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGDKEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAEREAESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPDQGNVVFTSAIDGWGFGIEHFAKIYSQKTGIRKEVLLKTLWGDYYINTKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKTDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISQAVLAMVCQKLPSPLDITAERVEKLMCAGSQTFDSLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAERRERARRRHAEKLAAAQGQAPVEPTQDAGALEMSPQGEEPKGDEQGVESETPKPVSPEGSEQESFIAFARVFSGVARKGKRIFVLGPKYSPLEFLQQVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCTSPSCPPFIPLNFEATPIVRVAIEPKHPSEMPQLVKGMKLLNQADPCVQVFIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSNGLITMMTPNKLATLSVRALPLPEEVTQILEESSDLIRSMEQLTSSLNEGKNNPQMIHQKTQEKIWEFKGKLEHHLTGRKWRNTVDQIWSFGPRKCGPNILVNKSEDFHNSVWTGLDGKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQTASNKQNQEPGDLVKERQGEGDTRSGGDEQQELQDYGSEPFEKRASQRGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLDNPQRPLLGTNHRGGVPALWGKG", "length": 1028, "header": "tr|A0A3Q1LPM1-1|A0AAA9SKN9_BOVIN Computationally mapped isoform of Elongation factor-like GTPase 1 OS=Bos taurus OX=9913 GN=EFL1 PE=4 SV=1 CANONICAL=A0AAA9SKN9-1" }, "locus": { "chromosome": "21", "start_pos": 24054165, "end_pos": 23941369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072435.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072435.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062034.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062034.2" } ] } }, { "isoform_ac": "A0AAA9SKN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#A0AAA9SKN9-1", "sequence": { "sequence": "MVLNSLDKMIQLQKNTANIRNICVLAHVDHGDKEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAEREAESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPDQGNVVFTSAIDGWGFGIEHFAKIYSQKTGIRKEVLLKTLWGDYYINTKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKTDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISQAVLAMVCQKLPSPLDITAERVEKLMCAGSQTFDSLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAERRERARRRHAEKLAAAQGQAPVEPTQDAGALEMSPQGEEPKGDEQGVESETPKPVSPEGSEQESFIAFARVFSGVARKGKRIFVLGPKYSPLEFLQQVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCTSPSCPPFIPLNFEATPIVRVAIEPKHPSEMPQLVKGMKLLNQADPCVQVFIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSNGLITMMTPNKLATLSVRALPLPEEVTQILEESSDLIRSMEQLTSSLNEGKNNPQMIHQKTQEKIWEFKGKLEHHLTGRKWRNTVDQIWSFGPRKCGPNILVNKSEDFHNSVWTGLDGKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQTASDLVKERQGEGDTRSGGDEQQELQDYGSEPFEKRASQRGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1070, "header": "tr|A0AAA9SKN9-1|A0AAA9SKN9_BOVIN Isoform 1 of Elongation factor-like GTPase 1 OS=Bos taurus OX=9913 GN=EFL1 PE=4 SV=1 CANONICAL=A0AAA9SKN9-1" }, "locus": { "chromosome": "21", "start_pos": 24054165, "end_pos": 23941251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106396.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106396.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084447.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084447.1" } ] } }, { "isoform_ac": "A0AAA9TE99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#A0AAA9TE99-1", "sequence": { "sequence": "MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGDKEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAEREAESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPDQGNVVFTSAIDGWGFGIEHFAKIYSQKTGIRKEVLLKTLWGDYYINTKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKTDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISQAVLAMVCQKLPSPLDITAERVEKLMCAGSQTFDSLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAERRERARRRHAEKLAAAQGQAPVEPTQDAGALEMSPQGEEPKGDEQGVESETPKPVSPEGSEQESFIAFARVFSGVARKGKRIFVLGPKYSPLEFLQQVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCTSPSCPPFIPLNFEATPIVRVAIEPKHPSEMPQLVKGMKLLNQADPCVQVFIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSNGLITMMTPNKLATLSVRALPLPEEVTQILEESSDLIRSMEQLTSSLNEGKNNPQMIHQKTQEKIWEFKGKLEHHLTGRKWRNTVDQIWSFGPRKCGPNILVNKSEDFHNSVWTGLDGKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQTASNKQNQEPGDLVKERQGEGDTRSGGDEQQELQDYGSEPFEKRASQRGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1129, "header": "tr|A0AAA9TE99-1|A0AAA9TE99_BOVIN Computationally mapped isoform of Elongation factor-like GTPase 1 OS=Bos taurus OX=9913 GN=EFL1 PE=4 SV=1 CANONICAL=A0AAA9SKN9-1" }, "locus": { "chromosome": "21", "start_pos": 24054165, "end_pos": 23941251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125021.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125021.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094501.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094501.1" } ] } }, { "isoform_ac": "E1BH79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9/entry#E1BH79-1", "sequence": { "sequence": "MLRYMDSREDEQVRGITMKSSAISLHYAEGDKEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAEREAESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPDQGNVVFTSAIDGWGFGIEHFAKIYSQKTGIRKEVLLKTLWGDYYINTKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKTDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISQAVLAMVCQKLPSPLDITAERVEKLMCAGSQTFDSLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAERRERARRRHAEKLAAAQGQAPVEPTQDAGALEMSPQGEEPKGDEQGVESETPKPVSPEGSEQESFIAFARVFSGVARKGKRIFVLGPKYSPLEFLQQVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCTSPSCPPFIPLNFEATPIVRVAIEPKHPSEMPQLVKGMKLLNQADPCVQVFIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSNGLITMMTPNKLATLSVRALPLPEEVTQILEESSDLIRSMEQLTSSLNEGKNNPQMIHQKTQEKIWEFKGKLEHHLTGRKWRNTVDQIWSFGPRKCGPNILVNKSEDFHNSVWTGLDGKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQTASNKQNQEPGDLVKERQGEGDTRSGGDEQQELQDYGSEPFEKRASQRGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1077, "header": "tr|E1BH79-1|E1BH79_BOVIN Computationally mapped isoform of Elongation factor-like GTPase 1 OS=Bos taurus OX=9913 GN=EFL1 PE=4 SV=3 CANONICAL=A0AAA9SKN9-1" }, "locus": { "chromosome": "21", "start_pos": 24054077, "end_pos": 23941251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047037.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047037.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044276.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044276.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527607", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527607", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BT76-1", "protein_name": "Elongation factor-like GTPase 1", "gene_name": "EFL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLNSLDKMIQLQKNTANIRNICVLAHVDHDDEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERVTESQVNPHSEQGEQVYDWSTGLEDTDDSHLYFSPDQGNVVFTSAIDGWGFGIEHFAKIYSQKTGIRKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILGNIWSLYDAVLKKDKEKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISQAVLAMVCQKLPSPLDITAERVEKLMCAGSQTFDSLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTPEEIAERRERARRRHAEKLAAAQGQAPVEPTQDGSALEASPKEEEPKGDEQQVLQEGNDQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLQRVPLGFSAPLDGLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCTLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLKERFAKIQISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQTKEDQSKIPEGIQVDSDGLVTITTPNKLATLCVRAMPLPEEVTQILEENSDLIRSMEQLTSSLNEGKNTQVIHQKTQEKIGEFKGRLEQHLTGRKWRNTVDQIWSFGPRKCGPNILVNKSEDFQNSVWTGPDGKASQEANRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQTASDKQNQKQSDLVDAGQGEGETSSAGDENQEVHNGCSEPFEKRPSQKGESSLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1069 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7FRL8-1", "protein_name": "Elongation factor-like GTPase 1", "gene_name": "Efl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLNGVDKMIQLQKHTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKLDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETDSQVKTQSEQGDQVYDWSTGLEDADDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDMTSERVEKLMCTGSQTFESLPLETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKTLPQNKPRPLTQEEIAQRRERARQRHAERLAGTQGQAPQGPTQDGGTLETGPQGDEPRGDEPDVASISPQPVAQEESSQEAFIAFARVFSGIARRGQKIFVLGPKYSPVEFLQRVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGRQQKVAVIHQTKEEQSKIPEGIHVDSDGLITITTPNKLATLSVRAIPLPEEVTQILEENSDLIRSMELLTSSLNEGRNTQGIHQKTQEKIWDFKGKLEQHLIGRKWRNTVDQIWSFGPRKCGPNILVSRSEDFQNSVWSGPAGKESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWELNKCAEQGASDKQNQKQCDLAEEGQEEGKTCHSGDENQEQQDGCSEPFEETSPKGESPVTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEVRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1127 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZXJ5-1", "protein_name": "Elongation factor-like GTPase 1", "gene_name": "Efl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLSGLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGSEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILGQINALTGTLFTSKVLEERAERETESQAKSHSEQGDQVYDWSTGLEDVDDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKVDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDMTSERVEKLMCTGSQTFESLPLETQALKAAFMKCGSEDTAPVIIFVSKMFAVDVKALPQNKPRPLTQEEMAQRRERARQRHAEKLAAAQGQAPQGPTQDGGALETSPQEDEPRGEEPDMTSVSRQPAPQEESSQEAFIAFARVFSGVARRGKKIFVLGPKYSPVDFLQRVPQGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDSVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGRQQKVAVIHQTKEEQSKIPEGILVDSDGLITIPTPNKLATLSVRAIPLPEEVTRILEENSDLIRSMELLTSSLNEGRNTQAIHQKTQEKIWEFKGKLEKHLTGRKWRNTVDQIWSFGPRKCGPNILVSRSEDFQSSVWSGPAGRESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWELNKCAEPGASDKQSQGQCDLTGEGQEKSKTCPVGDENQEQQDGYSEPFEETSQKGDSPVIDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1127 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NZK8-1", "protein_name": "Elongation factor-like GTPase 1", "gene_name": "EFL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVLTSVGKMMGLQQKAAGIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYLDSREDEQVRGITMKSSAISLHFEKGGQEYLINLIDSPGHVDFSSEVSTAVRLCDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKLTPQEAYMHLKNILEQINAVTGSLFTSKVLEERAEKEAESESSSDTAAGDQIYDWSAGLEDTDDSHLYFSPDHGNVVFASAIDGWGFGIEHFAKLYSQKIGIKPAVLLKTLWGDYYLNTKAKKIMKGDQSKGKKPLFVQLVLDNIWSLYEAVMKRDKEKIEKIVTSLGLKIGPRESRHADPKVHLNAICSQWLPISDAVLSMVCSKLPSPLDITAERVEKLMCVGAKTFDSLPPETQELKSAFLRCSSEETAPVIVFVSKMFAVDAKALPHNKPRPLTQEEIAQRRELAKQRHAGKMAANQGKEVSEKPPSENSSEGTGSTGDKKGEEQQLTDQMDVVTSKAAKQEADNKESFIAFARVFSGVVRRGQKIFVLGPKYDPAESLHKLSPQCSATDDLPSVPHMSCCTLENLYLLMGRELEELEEVPAGNVLGIGGLQDFVLKSATLSTSPACPPFTPLNFEATPIVRVAVEPKHPSDMPQLVRGMKLLNQADPCVQVLIQETGEHVLVTAGEVHLQRCLDDLKERFAKIEISVSAPIIPFRETITRPPKVDMVNEEIGKQQKVAVIHQTKEDQNKIPEGIQVDSDGLVTISTPNKQATLSVRALPLPEEVTRLLEENSDLIRTMEQLSTSLNEDKNAHEINQKTMDKIKEFKQKLEQNLQGRKWRNAVDHIWSFGPRKCGPNILLHKFEGYKNSVWQCLENTEKEVSKYGDFDNSIVSGFQLATLSGPMCEEPLMGVCFTVEKWEMNKVGETLLTKSRDSGECGAVEHQESEDTVSPTSNCTVDTCSENEHEQSSQSVPKSLEKNSKNKGEVLLTDCYGPFSGQLIATMKEACRYALQAKPQRLMAAMYTCEIMATAEVLGRVYAVLSKREGRVLQEEMKEGTDVFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIISSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSRNK", "length": 1139 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4J2T9-1", "protein_name": "Elongation factor-like 1", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDESEGRKVRNICILAHVDHGKTTLADHLIASSGGGVLHPRLAGKLRFMDYLDEEQRRAITMKSSSISLKYKDYSLNLIDSPGHMDFCSEVSTAARLSDGALVLVDAVEGVHIQTHAVLRQAWIEKLTPCLVLNKIDRLIFELRLSPMEAYTRLIRIVHEVNGIVSAYKSEKYLSDVDSILASPSGELSAESLELLEDDEEVTFQPQKGNVVFVCALDGWGFGIAEFANFYASKLGASATALQKSLWGPRYYIPKTKMIVGKKNLSAGSKAKPMFVQFVLEPLWQVYEAALDPGGDKAVLEKVIKSFNLSIPPRELQNKDPKNVLQSVMSRWLPLSDAVLSMAVKHLPDPIAAQAYRIPRLVPERKIIGGDDVDSSVLAEAELVRKSIEACDSSSDSPCVVFVSKMFAIPMKMIPQDGNHRERMNGLNDDDSKSESDECFLAFARIFSGVLRAGQRVFVITALYDPLKGESSHKYIQEAELHSLYLMMGQGLTPVTEVKAGNVVAIRGLGPYISKSATLSSTRNCWPLASMEFQVSPTLRVAIEPSDPADMSALMKGLRLLNRADPFVEITVSARGEHVLAAAGEVHLERCVKDLKERFAKVNLEVSPPLVSYRETIEGDGSNLLESLRSLSLNSSDYIEKRTPNGRCIIRVHVMKLPHALTKLLDENTELLGDIIGGKGSHSVKILESQKPSLGENVDPIEELKKQLVEAGVSSSSETEKDREKCKTEWSKLLKRIWALGPREKGPNILFAPDGKRIAEDGSMLVRGSPHVSQRLGFTEDSTETPAEVSETALYSEALTLESSIVSGFQLATASGPLCDEPMWGLAFTIESHLAPAEDVETDKPENFGIFTGQVMTAVKDACRAAVLQTNPRIVEAMYFCELNTAPEYLGPMYAVLSRRRARILKEEMQEGSSLFTVHAYVPVSESFGFADELRKGTSGGASALMVLSHWEMLEEDPFFVPKTEEEIEEFGDGASVLPNTARKLINAVRRRKGLHVEEKVVQYATKQRTLARKV", "length": 1015 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P53893-1", "protein_name": "Ribosome assembly protein 1", "gene_name": "RIA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPRVESETYKRLQNDPSCIRNICIVAHVDHGKTSLSDSLLASNGIISQRLAGKIRFLDARPDEQLRGITMESSAISLYFRVLRKQEGSDEPLVSEHLVNLIDSPGHIDFSSEVSAASRLCDGAVVLVDVVEGVCSQTVTVLRQCWTEKLKPILVLNKIDRLITELQLTPQEAYIHLSKVIEQVNSVIGSFFANERQLDDLFWREQLEKNENAEYIEKDDSGIYFNPTDNNVIFASAIDGWGFNIGQLAKFYEQKLGAKRENLQKVLWGDFYMDPKTKKIINNKGLKGRSLKPLFTSLILENIWKIYQNIITSRDSEMVEKIAKTLNIKLLARDLRSKDDKQLLRTIMGQWLPVSTAVLLTVIEKLPSPLESQTDRLNTILVSESDTAAMDPRLLKAMKTCDKEGPVSAYVSKMLSIPREELPVESKRIASSDELMERSRKAREEALNAAKHAGMVENMAMMDLNDNSKNTSDLYKRAKDTVMTPEVGEQTKPKPSRNNDVFCVVSEPSSALDLEFEYEGEDDSDSQDNFGLDFVPTDIDPNDPLSSMFEYEEEDPLLESIKQISEDVNDEVDDIFDEKEECLVAFARIYSGTLRVGQEISVLGPKYDPKCPEEHIETAIITHLYLFMGKELVPLDVCPSGNIVGIRGLAGKVLKSGTLIEKGVQGVNLAGVNFHFTPIVRVAVEPANPVEMSKLVRGLKLLDQADPCVHTYVENTGEHILCTAGELHLERCLKDLTERFAGIEITHSEPAIPYRETFLSASDMNPPQNSQLGRGVHELLLSQYKITFRTFPLSGKVTDFLSQHQNSIKNILKTSTSSMDPVIESTGSSFLDKKSLLVAFEEVINQEEKSRELLSGFKVKLAGFGPSRVGCNILLSQDNLLGSLFEGTPAAFEYSDSIKNGFQLAVSEGPLANEPVQGMCVLVESVHKMSQDEIESIEDPRYQQHIVDLSGRLITSTRDAIHEAFLDWSPRIMWAIYSCDIQTSVDVLGKVYAVILQRHGKIISEEMKEGTPFFQIEAHVPVVEAFGLSEDIRKRTSGAAQPQLVFSGFECIDLDPFWVPTTEEELEELGDTADRENIARKHMNAIRRRKGLFIEEKVVENAEKQRTLKKN", "length": 1110 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54WF2-1", "protein_name": "Ribosome assembly protein 1", "gene_name": "eftud1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPSISPNLLASLQDHTKNIRNICVLAHVDHGKTTLSDCLISSNGIISPEMAGKLRYLDFLEDEQEREITMKASAISLLFQQPSSSSSSNDKESFLINLIDSPGHVDFSSEVSTAVRITDGALVLVDAVEGVCIQTHAVLKQAYQEKVKPCLVLNKIDRLILELHMTPLEAYQHLSKIIEQVNVITGTLTSEEIILKESSEDYIESSDDSNLNFNENIGTEYYFSPQKGNVAFTTAFDGWGFTIKQFIDLCYKKTGIKKEILEKCLWGEYYYHPKEKKIYKSPKGNLMPMFVTFILNSVWEVVKTIVGTPEWIDRDRLDKMISVLNITVGARDLASKDQKIVLKSVLHAWLPLSEAVLSMVCDKLPDPIEGQARRMEKIFKPSKSLSTSSSSSSSSSNQSNVELIEKQKQLLYDTITCNSSDDCEIVAYVAKVFAHNKRGGVQTSTIHRPVPPRRVQPSAVPSQNRQQQLHQDEKDILKIDNMFISSAPSTTNDSTTTTKTTTTSPSSPITSTAKPLDLSTIPTGPIKANNNDEEFIAVVRVFSGVLKKGKTIYVMGPRYDPMNPTHDVYKVEITHLYLLMGSSLEPIDKVPAGNVCGVGGGVGNLVLKSATISSSLMCPPISNMMFVSSPIVKVALEPENISDLPKLLHGLKLLNQADPLVEVYVQETGEHVIVASGELHLERCIRDLKESFAKINVHVSSPIVPFRETIITPTITTPTTSSTITSSSSTTAAATATTTNNSGQQSPPLKEIITVKTANKKVSVKIRAIPLPKNITNLIEQRSQQLRDLFLGGKNTNKELSDNKITKREAEQAEREDFQKELEEELEKSGGDWKNEIKNIWSFGPRHIGPNLLLNHIPGYNLSPYWKHSLQRGIQKKLKKLQKQQQQEKEEIKEEEEEKEEEEKEDEEDEDEKEIEEEEIQEEENSNSEVGSIKLLDGDDKFKRISELDNSIVSGFQLATIAGPLCDEPMMGVCLIVEDIDIIREEGDQQNSDSYGPLSGQMISTVKEGCRMAFQIKPQRLMEALYLCEIQVTSTALGKMYSVLSSRRAQIQKEGVKEGTQIFCIQARLPVVESFGFSQQIMIKTSGAASTQLFFDNYWETIEQDPYYEPTTEEELEDNGVNIASLGNNIARQYMNMIRKRKGLFVEEKLVEHADKQRTLKKNK", "length": 1164 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7Z2Z2-1", "protein_name": "Elongation factor-like GTPase 1", "gene_name": "EFL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQIRGITMKSSAISLHYATGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILENIWSLYDAVLKKDKDKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCQKLPSPLDITAERVERLMCTGSQTFDSFPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQGQAPLEPTQDGSAIETCPKGEEPRGDEQQVESMTPKPVLQEENNQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLRRVPLGFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLVTAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQMKEDQSKIPEGIQVDSDGLITITTPNKLATLSVRAMPLPEEVTQILEENSDLIRSMEQLTSSLNEGENTHMIHQKTQEKIWEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKSEDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLSKFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1120 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C0D5-1", "protein_name": "Elongation factor-like GTPase 1", "gene_name": "Efl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLSGVDKMIRLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGHEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQAKPHSEQGEQVYDWSAGLEDVDDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCHKLPSPLDMTSERVEKLLCTGSQTFESLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDVKALPQNKPRPLTQEEMAQRRERARQRHAEKLAAAQGQTSQGPTQDGGALETSPHEDEPRGDEPDVASVSRQPVSQEESSQEAFIAFARVFSGIARRGKKIFVLGPKYSPVDFLQRVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQVLIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGRQQKVAVIHQTKEEQSKIPEGIHVDSDGLITIPTPNKLATLSVRAIPLPEEVTRILEENSDLIRSMELLTSSLNEGRNTQAIHQKTQEKIWEFKGKLEKHLTGRKWRNTVDQIWSFGPRKCGPNILVSRSEDFQNSVWSGPAGRESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWELNKCAEQGASDKQHQGQCDLAGEGQGGGKTCHVGDENQEQQDVCSEPFEETSQKGDSPVIDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK", "length": 1127 }, "evidence": [ { "id": "A0AAA9SKN9", "url": "https://omabrowser.org/oma/group/A0AAA9SKN9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytosolic ribosome assembly", "id": "GO:0042256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042256", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 788, "end_pos": 790, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN9" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 316, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 788, "end_pos": 790 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLE6-1", "uniprot_ac": "A0AAA9SLE6", "uniprot_id": "A0AAA9SLE6_BOVIN", "mass": { "chemical_mass": 25964.0, "monoisotopic_mass": 25964.0 }, "refseq": {}, "gene_names": [ { "name": "LOC509972", "type": "recommended", "evidence": [ { "id": "A0AAA9SLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ] } ], "protein_names": [ { "name": "C-type lectin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC509972", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLE6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLE6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049487", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049487", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509972", "url": "https://www.ncbi.nlm.nih.gov/gene/509972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509972", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509972", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HHIWRWT", "url": "https://omabrowser.org/oma/group/HHIWRWT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRJ4", "url": "https://www.orthodb.org/?gene=A0A3Q1LRJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MX84", "url": "https://www.orthodb.org/?gene=G3MX84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45710", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45710", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45710:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45710:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRJ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP29", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX84", "url": "https://www.uniprot.org/uniprotkb/G3MX84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX84-1", "url": "https://www.uniprot.org/uniprotkb/G3MX84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SQAPFYSPFPTGRGSLSVLDCRVLREGFGGPGPQEFTRRQVSQEPHLELLELEDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 230, "header": "tr|A0AAA9SLE6-1|A0AAA9SLE6_BOVIN Isoform 1 of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=1 CANONICAL=A0AAA9SLE6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#A0A3Q1LRJ4-1", "sequence": { "sequence": "MTPHSSTLAWKISWMEEPDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 195, "header": "tr|A0A3Q1LRJ4-1|A0AAA9SLE6_BOVIN Computationally mapped isoform of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=2 CANONICAL=A0AAA9SLE6-1" }, "locus": { "chromosome": "5", "start_pos": 100143089, "end_pos": 100117177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085636.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085636.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059627.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059627.2" } ] } }, { "isoform_ac": "A0AAA9RZW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#A0AAA9RZW7-1", "sequence": { "sequence": "PCLSHSGKSIQTSPTQDPDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 195, "header": "tr|A0AAA9RZW7-1|A0AAA9SLE6_BOVIN Computationally mapped isoform of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=1 CANONICAL=A0AAA9SLE6-1" }, "locus": { "chromosome": "5", "start_pos": 100143089, "end_pos": 100126673, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095937.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095937.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076910.1" } ] } }, { "isoform_ac": "A0AAA9SLE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#A0AAA9SLE6-1", "sequence": { "sequence": "SQAPFYSPFPTGRGSLSVLDCRVLREGFGGPGPQEFTRRQVSQEPHLELLELEDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 230, "header": "tr|A0AAA9SLE6-1|A0AAA9SLE6_BOVIN Isoform 1 of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=1 CANONICAL=A0AAA9SLE6-1" }, "locus": { "chromosome": "5", "start_pos": 100143089, "end_pos": 100135709, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119354.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119354.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084754.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084754.1" } ] } }, { "isoform_ac": "A0AAA9SP29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#A0AAA9SP29-1", "sequence": { "sequence": "MTMTEVSLKILETDSTYRVNMEQWRSDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 203, "header": "tr|A0AAA9SP29-1|A0AAA9SP29_BOVIN Computationally mapped isoform of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=1 CANONICAL=A0AAA9SLE6-1" }, "locus": { "chromosome": "5", "start_pos": 100143089, "end_pos": 100128316, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123675.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123675.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088074.1" } ] } }, { "isoform_ac": "A0AAA9T4S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#A0AAA9T4S4-1", "sequence": { "sequence": "MMLSNRLLYFRDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 188, "header": "tr|A0AAA9T4S4-1|A0AAA9T4S4_BOVIN Computationally mapped isoform of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=1 CANONICAL=A0AAA9SLE6-1" }, "locus": { "chromosome": "5", "start_pos": 100143089, "end_pos": 100128742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095429.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095429.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091507.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091507.1" } ] } }, { "isoform_ac": "G3MX84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6/entry#G3MX84-1", "sequence": { "sequence": "MAISPGLGPLVRDFGNRGDKDLRKKCLAIISPVTPAKFCCCILIIFILVALYLVTLSALLAVRSRETDLLILYVSCPKGWIGFGSKCFYFSEDSKNWTFSQTSCTSVGAVLAQFETEEELNFLRRYKGIFDHWIGLSRESSHHAWKWTDNSKYNASFIITGDGERGYLNDLGVSSARSYTDRKWICSKQITSACP", "length": 195, "header": "tr|G3MX84-1|G3MX84_BOVIN Computationally mapped isoform of C-type lectin domain-containing protein OS=Bos taurus OX=9913 GN=LOC509972 PE=4 SV=2 CANONICAL=A0AAA9SLE6-1" }, "locus": { "chromosome": "5", "start_pos": 100143089, "end_pos": 100136771, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065136.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065136.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054144.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054144.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 69, "start_aa": "Thr", "end_pos": 69, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr69", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509972", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509972", "resource": "KEGG Pathway" }, { "id": "R-BTA-198933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZA8-1", "protein_name": "C-type lectin domain family 2, member H", "gene_name": "Clec2h", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAVKIEEASVDKLKIHLTATACLQEEDKGKVLQGKLLRSISPESRVKLHCCYGVVIVVLTVAVVALSVALSVRNKIPVMENCEPCSATCPSGWIGFGSKCFYFSEDVGNWTFSQSSCMALDSHLALFDSLEELIFLKRYKGPSDHWIGLHRASTKHPWIWADDTEYSNLVLIRGGGQCGFLSDNGISSGRDYTHRKWICNKSSSICKSKLGNVPRHV", "length": 218 }, "evidence": [ { "id": "A0AAA9SLE6", "url": "https://omabrowser.org/oma/group/A0AAA9SLE6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C1T8-1", "protein_name": "C-type lectin domain family 2 member H", "gene_name": "Clec2h", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNAAKVETSSMGMLQRADLTAADCLQEGEMGKKIQGKCFRIISTVSPVKLYCCYGVIMVLTVAVIALSVALSVRNKIPAMEDREPCYTACPSGWIGFGSKCFYFSEDMGNWTFSQSSCVASNSHLALFHSLEELNFLKRYKGTSDHWIGLHRASTQHPWIWTDNTEYSNLVLTRGGGECGFLSDNGISSGRSYTHRKWICSKFVSSCKSRVGSVPRHV", "length": 218 }, "evidence": [ { "id": "A0AAA9SLE6", "url": "https://omabrowser.org/oma/group/A0AAA9SLE6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "natural killer cell lectin-like receptor binding", "id": "GO:0046703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046703", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" }, { "name": "NK T cell activation", "id": "GO:0051132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051132", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE6" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 118, "end_pos": 230, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 69 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 189, "end_pos": 191 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK01-1", "uniprot_ac": "A0AAA9SK01", "uniprot_id": "A0AAA9SK01_BOVIN", "mass": { "chemical_mass": 27178.0, "monoisotopic_mass": 27178.0 }, "refseq": {}, "gene_names": [ { "name": "KCTD14", "type": "recommended", "evidence": [ { "id": "A0AAA9SK01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01" } ] } ], "protein_names": [ { "name": "Potassium channel tetramerization domain containing 14", "type": "synonym", "evidence": [ { "id": "A0AAA9SK01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01", "locus": { "chromosome": "29", "start_pos": 18030392, "end_pos": 18005020, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056326", "url": "https://www.ensembl.org/id/ENSBTAG00000056326" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011668", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011668", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18371", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18371", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25611", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25611", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDD6", "url": "https://www.uniprot.org/uniprotkb/F1MDD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDD6-1", "url": "https://www.uniprot.org/uniprotkb/F1MDD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMNHELPGDGTVGHSASCAPQESPVVELNVGGEFYTTTLGTLRKFPGSKLAEMFSSPAKACLDAEGRFFIDRCGTYFGPILEYLRSGQLPTQHIPEVYREAQHYEIKPLIKHLEDTPQIFGEQVARKQFLLQVPGYSENLELMVRLARAEAVAARCSRVLVCLVRNEKEDANCADALRSLEANKRSVVKFGPWKAALDISDLLDCLNMDIKAQGYQVCYSHNSPLPAKVSDYFYTFSFSWW", "length": 242, "header": "tr|A0AAA9SK01-1|A0AAA9SK01_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 14 OS=Bos taurus OX=9913 GN=KCTD14 PE=4 SV=1 CANONICAL=A0AAA9SK01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01/entry#A0AAA9SK01-1", "sequence": { "sequence": "MKMNHELPGDGTVGHSASCAPQESPVVELNVGGEFYTTTLGTLRKFPGSKLAEMFSSPAKACLDAEGRFFIDRCGTYFGPILEYLRSGQLPTQHIPEVYREAQHYEIKPLIKHLEDTPQIFGEQVARKQFLLQVPGYSENLELMVRLARAEAVAARCSRVLVCLVRNEKEDANCADALRSLEANKRSVVKFGPWKAALDISDLLDCLNMDIKAQGYQVCYSHNSPLPAKVSDYFYTFSFSWW", "length": 242, "header": "tr|A0AAA9SK01-1|A0AAA9SK01_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 14 OS=Bos taurus OX=9913 GN=KCTD14 PE=4 SV=1 CANONICAL=A0AAA9SK01-1" }, "locus": { "chromosome": "29", "start_pos": 18026161, "end_pos": 18025436, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084179.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084179.1" } ] } }, { "isoform_ac": "F1MDD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01/entry#F1MDD6-1", "sequence": { "sequence": "MPTAARISDLYEIRIFITIPSTGCGHTESPVVELNVGGEFYTTTLGTLRKFPGSKLAEMFSSPAKACLDAEGRFFIDRCGTYFGPILEYLRSGQLPTQHIPEVYREAQHYEIKPLIKHLEDTPQIFGEQVARKQFLLQVPGYSENLELMVRLARAEAVAARCSRVLVCLVRNEKEDANCADALRSLEANKRSVVKFGPWKAALDISDLLDCLNMDIKAQGYQVCYSHNSPLPAKVSDYFYTFSFSWW", "length": 247, "header": "tr|F1MDD6-1|A0AAA9SK01_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 14 OS=Bos taurus OX=9913 GN=KCTD14 PE=4 SV=4 CANONICAL=A0AAA9SK01-1" }, "locus": { "chromosome": "29", "start_pos": 18026161, "end_pos": 18024875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015491.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015491.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015491.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015491.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK01" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 122, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKU8-1", "uniprot_ac": "A0AAA9SKU8", "uniprot_id": "A0AAA9SKU8_BOVIN", "mass": { "chemical_mass": 22142.0, "monoisotopic_mass": 22142.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM235", "type": "recommended", "evidence": [ { "id": "A0AAA9SKU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8" } ] } ], "protein_names": [ { "name": "Transmembrane protein 235", "type": "synonym", "evidence": [ { "id": "A0AAA9SKU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKU8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024926", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024926", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LWRTCEG", "url": "https://omabrowser.org/oma/group/LWRTCEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFH6", "url": "https://www.orthodb.org/?gene=F1MFH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20516", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20516", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20516:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20516:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13903", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13903", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFH6", "url": "https://www.uniprot.org/uniprotkb/F1MFH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFH6-1", "url": "https://www.uniprot.org/uniprotkb/F1MFH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRLGALLLAAALGALLSFALLAAAVASDYWYLLEVADAGNHSGHGQLSSHSGLWRICEGHNSCIPLIDPFASESLDASTSVQHLISLHRAVLVVLPVSLVLIVCGWICGLLSSLAQSIRLLLFTGCYFLLGGALTLAGVIIYISYSQLAFAETARQYGPQHMQDVRISFGWSLALAWGSCAAESLSGALLLTAARGLSLGGQPGAPHSVVI", "length": 212, "header": "tr|A0AAA9SKU8-1|A0AAA9SKU8_BOVIN Isoform 1 of Transmembrane protein 235 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SKU8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8/entry#A0AAA9SKU8-1", "sequence": { "sequence": "MSRLGALLLAAALGALLSFALLAAAVASDYWYLLEVADAGNHSGHGQLSSHSGLWRICEGHNSCIPLIDPFASESLDASTSVQHLISLHRAVLVVLPVSLVLIVCGWICGLLSSLAQSIRLLLFTGCYFLLGGALTLAGVIIYISYSQLAFAETARQYGPQHMQDVRISFGWSLALAWGSCAAESLSGALLLTAARGLSLGGQPGAPHSVVI", "length": 212, "header": "tr|A0AAA9SKU8-1|A0AAA9SKU8_BOVIN Isoform 1 of Transmembrane protein 235 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SKU8-1" }, "locus": { "chromosome": "19", "start_pos": 53933612, "end_pos": 53928095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098088.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098088.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084503.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084503.1" } ] } }, { "isoform_ac": "F1MFH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8/entry#F1MFH6-1", "sequence": { "sequence": "MSRLGALLLAAALGALLSFALLAAAVASDYWYLLEVADAGNHSGHGQLSSHSGLWRICEGHNSCIPLIDPFASESLDASTSVQHLISLHRAVLVVLPVSLVLIVCGWICGLLSSLAQSIRLLLFTGCYFLLGVQGKPVTRSVCVSVHPETSCACCVCPSVRSRLRQTRSALSHFWPAQAGRTPGASRWFQGLALWAGPLSLGGSPLTSPSSLTAAGAQQCEGLTLGGPDTHG", "length": 232, "header": "tr|F1MFH6-1|A0AAA9SKU8_BOVIN Computationally mapped isoform of Transmembrane protein 235 OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=A0AAA9SKU8-1" }, "locus": { "chromosome": "19", "start_pos": 53933612, "end_pos": 53926374, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034726.4", "url": "https://www.ensembl.org/id/ENSBTAT00000034726.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034611.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034611.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A6NFC5-1", "protein_name": "Transmembrane protein 235", "gene_name": "TMEM235", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARLGALLLAAALGALLSFALLAAAVASDYWYILEVADAGNGSAWPGRAELLSSHSGLWRICEGQNGCIPLVDPFASESLDVSTSVQHLILLHRAVIVVLPLSLVLLVCGWICGLLSSLAQSVSLLLFTGCYFLLGSVLTLAGVSIYISYSHLAFAETVQQYGPQHMQGVRVSFGWSMALAWGSCALEAFSGTLLLSAAWTLSLSPPICGHLSPQQVGGRGGD", "length": 223 }, "evidence": [ { "id": "A0AAA9SKU8", "url": "https://omabrowser.org/oma/group/A0AAA9SKU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B1AQL3-1", "protein_name": "Transmembrane protein 235", "gene_name": "Tmem235", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALLATLLLSAALGALLSFALLAAAVASDYWYILEVADAGGLGGVQLFSHSGLWRTCEGQNSCVPLIDPFASAGLEVSPSVQHLLSLHRTVMVVLPLSLVLIVCGWVCGLLSSLSQSVPLLLATGCYFLLGGALTLAGLSIYISYSHLAFVEAARTYGVTHVQNVHISFGWSLALAWASCASEVLSGALLLAAARLLSLSQRPGVPHSVIL", "length": 211 }, "evidence": [ { "id": "A0AAA9SKU8", "url": "https://omabrowser.org/oma/group/A0AAA9SKU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3H3F3-1", "protein_name": "Transmembrane protein 235", "gene_name": "Tmem235", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALVAALLLSAALGALLSFALLAAAVASDYWYILEVANAGGSGSGGGAQQLSSHSGLWRTCEGHNSCVPLVDPFASDSLEASPSIQHLLSLHRTVMVVLPLSLILIVCGWVCGLLSSLSQSVPLLLITGCYFLLGGALTLAGVSVYISYSHLAFVETARLYGVQHVQDVHISFGWSLALAWGSCALEVLSGALLLTAARFLSLSQHPGMPHSVII", "length": 215 }, "evidence": [ { "id": "A0AAA9SKU8", "url": "https://omabrowser.org/oma/group/A0AAA9SKU8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0R4D0-1", "protein_name": "Transmembrane protein 235", "gene_name": "Tmem235", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLAALFLSAALGALLSFALLAAAVASDYWYILEVADAGSSGGARLSSHSGLWRTCEGQNSCVPLIDPFASSGLEASPSIQHLLSLHRTVMVVLPLSLILIVCGWVCGLLSSLSQSVPLLLATGCYFLLGGALTLAGLSVYICYSQLAFVEAARLYGLQHVQSVHISFGWSLALAWGSCASEVLSGALLLAAARLLTLSQHPGMPHSVIL", "length": 211 }, "evidence": [ { "id": "A0AAA9SKU8", "url": "https://omabrowser.org/oma/group/A0AAA9SKU8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 41, "end_pos": 43 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKK8-1", "uniprot_ac": "A0AAA9SKK8", "uniprot_id": "A0AAA9SKK8_BOVIN", "mass": { "chemical_mass": 179519.0, "monoisotopic_mass": 179519.0 }, "refseq": {}, "gene_names": [ { "name": "MAP3K4", "type": "recommended", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ], "protein_names": [ { "name": "Mitogen-activated protein kinase kinase kinase 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.25", "type": "synonym", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#names_and_taxonomy" } ] }, { "name": "MAPK/ERK kinase kinase 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ2#function" }, { "database": "UniProtKB", "id": "ARBA00060115", "url": "https://www.uniprot.org/uniprotkb/ARBA00060115#function" }, { "database": "UniProtKB", "id": "A0A3Q1MAA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA5#function" }, { "database": "UniProtKB", "id": "A0A3Q1MPE5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPE5#function" }, { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAP3K4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8", "locus": { "chromosome": "9", "start_pos": 96779916, "end_pos": 96631663, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020079", "url": "https://www.ensembl.org/id/ENSBTAG00000020079" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020079", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020079", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06626", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06626", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSJ2", "url": "https://www.orthodb.org/?gene=A0A3Q1LSJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAA5", "url": "https://www.orthodb.org/?gene=A0A3Q1MAA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPE5", "url": "https://www.orthodb.org/?gene=A0A3Q1MPE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48016:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48016:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPE5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPE5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREAAAAAAPVPPLACAVTSAAMEEPPPPPPPEPEPERCRAARQECVLGDSACKNSESDPEDFSDEANTENLYGTSPPSTPRQMKRMSSKHQRNSVGRPAGRANLKEKMNASNQPPHRDTGKTVENVEEYSYKQEKKIRAALRSTERDHKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQESTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSFAFVRNGASLNGTSVEGQFGAPHGTQPAGYSTYHEHLQRQRVSFEQVKRIMELLEYIEALYPSMQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRSSRGNEPEDEAEDTEGELKELDSSTEESEEEQSCGPRAPEPRPPADHSRHVQSPPDCVPKKLERLESEDESVGWGAPDWSAEAGVSGHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKSDGPVEFSGFPDPMWGSDYVQLSRTPPSSEQKCSTVSWEELRSMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLHEVLDQLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQELPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAEFWTSADDSSASDEIRRSVIEVSRALKELFHEARERASKALGFAKMLRKDLEIAAEFILSAPVRDLLDVLKAKQYVKVQIPGLENLQVFVPDALAEEKSIILQLLNAATGKDCSKDSDEALIDDYLLLTKHGDRTPDSEASWAAWEAQPVKVVPPVETVDTLRSMQVDNLLLVVMHSAQLIIHRKAFQQSIEGLMTLRQEQTSSQPVIAKALQQLKNDALELCNRISDAIDRVDHMFTSEFDAEVDESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFKQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPSFISALPEDDFLSLQALMNECIGHVIGKPHSPITGLYFAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSARSVPADVRSLGSPAPAPAAARPGPSGSDPAPPKPISGAHETRGSSVPENDRLASIAAELQFRSLSRHSSPTEEREEPAYPKGDSSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITVAINVLHEHGIVHRDVKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESEPRMRWTASQLLDHSFVKVCTDEE", "length": 1594, "header": "tr|A0AAA9SKK8-1|A0AAA9SKK8_BOVIN Isoform 1 of Mitogen-activated protein kinase kinase kinase 4 OS=Bos taurus OX=9913 GN=MAP3K4 PE=3 SV=1 CANONICAL=A0AAA9SKK8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#A0A3Q1LSJ2-1", "sequence": { "sequence": "MREAAAAAAPVPPLACAVTSAAMEEPPPPPPPEPEPERCRAARQECVLGDSACKNSESDPEDFSDEANTENLYGTSPPSTPRQMKRMSSKHQRNSVGRPAGRANLKEKMNASNQPPHRDTGKTVENVEEYSYKQEKKIRAALRSTERDHKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQESTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSFAFVRNGASLNGTSVEGQFGAPHGTQPAGYSTYHEHLQRQRVSFEQVKRIMELLEYIEALYPSMQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRSSRGNEPEDEAEDTEGELKELDSSTEESEEEQSCGPRAPEPRPPADHSRHVQSPPDCVPKKLERLESEDESVGWGAPDWSAEAGVSGHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKSDGPVEFSGFPDPMWGSDYVQLSRTPPSSEQKCSTVSWEELRSMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLHEVLDQLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQELPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFWRSVIEVSRALKELFHEARERASKALGFAKMLRKDLEIAAEFILSAPVRDLLDVLKAKQYVKVQIPGLENLQVFVPDALAEEKSIILQLLNAATGKDCSKDSDEALIDDYLLLTKHGDRTPDSEASWAAWEAQPVKVVPPVETVDTLRSMQVDNLLLVVMHSAQLIIHRKAFQQSIEGLMTLRQEQTSSQPVIAKALQQLKNDALELCNRISDAIDRVDHMFTSEFDAEVDESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFKQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPSFISALPEDDFLSLQALMNECIGHVIGKPHSPITAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSARSVPADVRSLGSPAPAPAAARPGPSGSDPAPPKPISGAHETRGSSVPENDRLASIAAELQFRSLSRHSSPTEEREEPAYPKGDSSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITVAINVLHEHGIVHRDVKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESEPRMRWTASQLLDHSFVKVCTDEE", "length": 1551, "header": "tr|A0A3Q1LSJ2-1|A0AAA9SKK8_BOVIN Computationally mapped isoform of Mitogen-activated protein kinase kinase kinase 4 OS=Bos taurus OX=9913 GN=MAP3K4 PE=3 SV=2 CANONICAL=A0AAA9SKK8-1" }, "locus": { "chromosome": "9", "start_pos": 96778912, "end_pos": 96674478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071880.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071880.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060219.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060219.2" } ] } }, { "isoform_ac": "A0A3Q1MAA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#A0A3Q1MAA5-1", "sequence": { "sequence": "MREAAAAAAPVPPLACAVTSAAMEEPPPPPPPEPEPERCRAARQECVLGDSACKNSESDPEDFSDEANTENLYGTSPPSTPRQMKRMSSKHQRNSVGRPAGRANLKEKMNASNQPPHRDTGKTVENVEEYSYKQEKKIRAALRSTERDHKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQESTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSFAFVRNGASLNGTSVEGQFGAPHGTQPAGYSTYHEHLQRQRVSFEQVKRIMELLEYIEALYPSMQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRSSRGNEPEDEAEDTEGELKELDSSTEESEEEQSCGPRAPEPRPPADHSRHVQSPPDCVPKKLERLESEDESVGWGAPDWSAEAGVSGHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKSDGPVEFSGFPDPMWGSDYVQLSRTPPSSEQKCSTVSWEELRSMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLHEVLDQLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQELPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAEFWTSADDSSASDEIRRSVIEVSRALKELFHEARERASKALGFAKMLRKDLEIAAEFILSAPVRDLLDVLKAKQYVKVQIPGLENLQVFVPDALAEEKSIILQLLNAATGKDCSKDSDEALIDDYLLLTKHGDRTPDSEASWAAWEAQPVKVVPPVETVDTLRSMQVDNLLLVVMHSAQLIIHRKAFQQSIEGLMTLRQEQTSSQPVIAKALQQLKNDALELCNRISDAIDRVDHMFTSEFDAEVDESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFKQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPSFISALPEDDFLSLQALMNECIGHVIGKPHSPITGLYFAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRHSSPTEEREEPAYPKGDSSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITVAINVLHEHGIVHRDVKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESEPRMRWTASQLLDHSFVKVCTDEE", "length": 1551, "header": "tr|A0A3Q1MAA5-1|A0AAA9SKK8_BOVIN Computationally mapped isoform of Mitogen-activated protein kinase kinase kinase 4 OS=Bos taurus OX=9913 GN=MAP3K4 PE=3 SV=3 CANONICAL=A0AAA9SKK8-1" }, "locus": { "chromosome": "9", "start_pos": 96778912, "end_pos": 96674478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074485.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074485.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067143.3", "url": "https://www.ensembl.org/id/ENSBTAP00000067143.3" } ] } }, { "isoform_ac": "A0A3Q1MPE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#A0A3Q1MPE5-1", "sequence": { "sequence": "MREAAAAAAPVPPLACAVTSAAMEEPPPPPPPEPEPERCRAARQECVLGDSACKNSESDPEDFSDEANTENLYGTSPPSTPRQMKRMSSKHQRNSVGRPAGRANLKEKMNASNQPPHRDTGKTVENVEEYSYKQEKKIRAALRSTERDHKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQESTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSFAFVRNGASLNGTSVEGQFGAPHGTQPAGYSTYHEHLQRQRVSFEQVKRIMELLEYIEALYPSMQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRSSRGNEPEDEAEDTEGELKELDSSTEESEEEQSCGPRAPEPRPPADHSRHVQSPPDCVPKKLERLESEDESVGWGAPDWSAEAGVSGHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKSDGPVEFSGFPDPMWGSDYVQLSRTPPSSEQKCSTVSWEELRSMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLHEVLDQLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQELPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAEFWTSADDSSASDEIRRSVIEVSRALKELFHEARERASKALGFAKMLRKDLEIAAEFILSAPVRDLLDVLKAKQYVKVQIPGLENLQVFVPDALAEEKSIILQLLNAATGKDCSKDSDEALIDDYLLLTKHGDRTPDSEASWAAWEAQPVKVVPPVETVDTLRSMQVDNLLLVVMHSAQLIIHRKAFQQSIEGLMTLRQEQTSSQPVIAKALQQLKYHKEVVRLMSGEFKQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPSFISALPEDDFLSLQALMNECIGHVIGKPHSPITAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSARSVPADVRSLGSPAPAPAAARPGPSGSDPAPPKPISGAHETRGSSVPENDRLASIAAELQFRSLSRHSSPTEEREEPAYPKGDSSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITVAINVLHEHGIVHRDVKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESEPRMRWTASQLLDHSFVKVCTDEE", "length": 1536, "header": "tr|A0A3Q1MPE5-1|A0AAA9SKK8_BOVIN Computationally mapped isoform of Mitogen-activated protein kinase kinase kinase 4 OS=Bos taurus OX=9913 GN=MAP3K4 PE=3 SV=2 CANONICAL=A0AAA9SKK8-1" }, "locus": { "chromosome": "9", "start_pos": 96778912, "end_pos": 96674478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084288.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084288.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073312.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073312.2" } ] } }, { "isoform_ac": "A0AAA9SKK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8/entry#A0AAA9SKK8-1", "sequence": { "sequence": "MREAAAAAAPVPPLACAVTSAAMEEPPPPPPPEPEPERCRAARQECVLGDSACKNSESDPEDFSDEANTENLYGTSPPSTPRQMKRMSSKHQRNSVGRPAGRANLKEKMNASNQPPHRDTGKTVENVEEYSYKQEKKIRAALRSTERDHKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQESTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSFAFVRNGASLNGTSVEGQFGAPHGTQPAGYSTYHEHLQRQRVSFEQVKRIMELLEYIEALYPSMQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRSSRGNEPEDEAEDTEGELKELDSSTEESEEEQSCGPRAPEPRPPADHSRHVQSPPDCVPKKLERLESEDESVGWGAPDWSAEAGVSGHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKSDGPVEFSGFPDPMWGSDYVQLSRTPPSSEQKCSTVSWEELRSMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLHEVLDQLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQELPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAEFWTSADDSSASDEIRRSVIEVSRALKELFHEARERASKALGFAKMLRKDLEIAAEFILSAPVRDLLDVLKAKQYVKVQIPGLENLQVFVPDALAEEKSIILQLLNAATGKDCSKDSDEALIDDYLLLTKHGDRTPDSEASWAAWEAQPVKVVPPVETVDTLRSMQVDNLLLVVMHSAQLIIHRKAFQQSIEGLMTLRQEQTSSQPVIAKALQQLKNDALELCNRISDAIDRVDHMFTSEFDAEVDESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFKQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPSFISALPEDDFLSLQALMNECIGHVIGKPHSPITGLYFAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSARSVPADVRSLGSPAPAPAAARPGPSGSDPAPPKPISGAHETRGSSVPENDRLASIAAELQFRSLSRHSSPTEEREEPAYPKGDSSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITVAINVLHEHGIVHRDVKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESEPRMRWTASQLLDHSFVKVCTDEE", "length": 1594, "header": "tr|A0AAA9SKK8-1|A0AAA9SKK8_BOVIN Isoform 1 of Mitogen-activated protein kinase kinase kinase 4 OS=Bos taurus OX=9913 GN=MAP3K4 PE=3 SV=1 CANONICAL=A0AAA9SKK8-1" }, "locus": { "chromosome": "9", "start_pos": 96778912, "end_pos": 96674478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093164.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093164.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086870.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086870.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" }, { "name": "MAP kinase kinase kinase activity", "id": "GO:0004709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "p38MAPK cascade", "id": "GO:0038066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" }, { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" }, { "name": "positive regulation of p38MAPK cascade", "id": "GO:1900745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900745", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" }, { "name": "response to UV-C", "id": "GO:0010225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1486, "end_pos": 1488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 724, "end_pos": 726, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 1329, "end_pos": 1587, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.25", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25" }, { "id": "2.7.11.25", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 1486, "end_pos": 1488 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 310, "end_pos": 312 }, { "start_pos": 390, "end_pos": 392 }, { "start_pos": 410, "end_pos": 412 }, { "start_pos": 724, "end_pos": 726 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKQ0-1", "uniprot_ac": "A0AAA9SKQ0", "uniprot_id": "A0AAA9SKQ0_BOVIN", "mass": { "chemical_mass": 46092.0, "monoisotopic_mass": 46092.0 }, "refseq": {}, "gene_names": [ { "name": "NDRG4", "type": "recommended", "evidence": [ { "id": "A0AAA9SKQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ] } ], "protein_names": [ { "name": "Protein NDRG4", "type": "recommended", "evidence": [ { "id": "A0AAA9SKQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MBK3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK3#function" }, { "database": "UniProtKB", "id": "RU367129", "url": "https://www.uniprot.org/uniprotkb/RU367129#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDRG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0", "locus": { "chromosome": "18", "start_pos": 26298396, "end_pos": 26256243, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003894", "url": "https://www.ensembl.org/id/ENSBTAG00000003894" } ] } } ], "crossref": [ { "id": "A0AAA9SKQ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003894", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003894", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515033", "url": "https://www.ncbi.nlm.nih.gov/gene/515033", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515033", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515033", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHPPDFE", "url": "https://omabrowser.org/oma/group/EHPPDFE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVG9", "url": "https://www.orthodb.org/?gene=A0A3Q1LVG9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBA1", "url": "https://www.orthodb.org/?gene=A0A3Q1MBA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBK3", "url": "https://www.orthodb.org/?gene=A0A3Q1MBK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LVG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVG9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBA1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBK3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R752", "url": "https://www.uniprot.org/uniprotkb/F6R752", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R752-1", "url": "https://www.uniprot.org/uniprotkb/F6R752-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVSNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDISRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYISGACVSLGGQAYRERPGESSQESNSRPPGDRAPCSLSGDKRGNERPSPTVRPGGDTEPRRCLENTAGTGGALSQHDSSCPLSHSIPHQRQLGGRQPPAGLHPLGEQRGAGPGQPHHGGVLLKPRSHEDAHSPPHPH", "length": 425, "header": "tr|A0AAA9SKQ0-1|A0AAA9SKQ0_BOVIN Isoform 1 of Protein NDRG4 OS=Bos taurus OX=9913 GN=NDRG4 PE=3 SV=2 CANONICAL=A0AAA9SKQ0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0/entry#A0A3Q1LVG9-1", "sequence": { "sequence": "MKVLGHKIELLTGLLLHDVTMAGLQELRFPEEKPLLRGQDAAELENSDSFLLAVDTDWKEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVSNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDISRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGGAVPSASMTRLARSRTASLTSANSVDGSRPQACTHSESSEGLGQVNHTMEVSC", "length": 404, "header": "tr|A0A3Q1LVG9-1|A0AAA9SKQ0_BOVIN Computationally mapped isoform of Protein NDRG4 OS=Bos taurus OX=9913 GN=NDRG4 PE=3 SV=3 CANONICAL=A0AAA9SKQ0-1" }, "locus": { "chromosome": "18", "start_pos": 26296446, "end_pos": 26256442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085690.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085690.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064628.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064628.3" } ] } }, { "isoform_ac": "A0A3Q1MBA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0/entry#A0A3Q1MBA1-1", "sequence": { "sequence": "MAGLQELRFPEEKPLLRGQDAAELENSDSFLLAVDTDWKEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKVSAVHLEGGGAGGAGRSQGQGRAGGLERRLLNWPLPGPQLSGLTSTLPDTVLSHLFSQEELVSNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDISRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYMPSASMTRLARSRTASLTSANSVDGSRPQACTHSESSEGLGQVNHTMEVSC", "length": 410, "header": "tr|A0A3Q1MBA1-1|A0A3Q1MBA1_BOVIN Computationally mapped isoform of NDRG family member 4 OS=Bos taurus OX=9913 GN=NDRG4 PE=3 SV=2 CANONICAL=A0AAA9SKQ0-1" }, "locus": { "chromosome": "18", "start_pos": 26296446, "end_pos": 26274966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078043.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078043.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067949.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067949.2" } ] } }, { "isoform_ac": "A0A3Q1MBK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0/entry#A0A3Q1MBK3-1", "sequence": { "sequence": "MAGLQELRFPEEKPLLRGQDAAELEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVSNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDISRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYMPSASMTRLARSRTASLTSANSVDGSRPQACTHSESSEGLGQVNHTMEVSC", "length": 356, "header": "tr|A0A3Q1MBK3-1|A0AAA9SKQ0_BOVIN Computationally mapped isoform of Protein NDRG4 OS=Bos taurus OX=9913 GN=NDRG4 PE=3 SV=3 CANONICAL=A0AAA9SKQ0-1" }, "locus": { "chromosome": "18", "start_pos": 26296446, "end_pos": 26274966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071768.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071768.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071481.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071481.3" } ] } }, { "isoform_ac": "A0AAA9SKQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0/entry#A0AAA9SKQ0-1", "sequence": { "sequence": "MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVSNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDISRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYISGACVSLGGQAYRERPGESSQESNSRPPGDRAPCSLSGDKRGNERPSPTVRPGGDTEPRRCLENTAGTGGALSQHDSSCPLSHSIPHQRQLGGRQPPAGLHPLGEQRGAGPGQPHHGGVLLKPRSHEDAHSPPHPH", "length": 425, "header": "tr|A0AAA9SKQ0-1|A0AAA9SKQ0_BOVIN Isoform 1 of Protein NDRG4 OS=Bos taurus OX=9913 GN=NDRG4 PE=3 SV=2 CANONICAL=A0AAA9SKQ0-1" }, "locus": { "chromosome": "18", "start_pos": 26296493, "end_pos": 26285078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130869.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130869.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084489.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084489.2" } ] } }, { "isoform_ac": "F6R752-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0/entry#F6R752-1", "sequence": { "sequence": "MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVSNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDISRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKPGKLTEAFKYFLQGMGYMPSASMTRLARSRTASLTSANSVDGSRPQACTHSESSEGLGQVNHTMEVSC", "length": 327, "header": "tr|F6R752-1|F6R752_BOVIN Computationally mapped isoform of Protein NDRG4 OS=Bos taurus OX=9913 GN=NDRG4 PE=3 SV=1 CANONICAL=A0AAA9SKQ0-1" }, "locus": { "chromosome": "18", "start_pos": 26296446, "end_pos": 26285078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005083.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005083.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005083.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005083.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515033", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515033", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZZ15-1", "protein_name": "NDRG family member 4", "gene_name": "NDRG4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATFLGTPRTQPCIRSSPVSSIASPCSLSCTAPPYPSQLHSCPFVPPSLVPIIRPSPAPLPAPSPAPSLLSVPAEGRIRSPGPCRLAPAPPCALLSAPLRSGSARSPRRGRRPGMKVLRHKIELLTGLLLQEMTMAGLHELRFTEEKPLLRGQDAELENSDVFLSTADTDWKEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNYEDMQEITKHFVVCHVDAPGQQAGASQFPQGYQYPSMDQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAAAKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGSVVNQFNLQLFLNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEEGVVECNSKLDPTNTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYMPSASMTRLARSRTASLTSASSVEGARPRACTHSESSEAMGQINHTMEVSC", "length": 504 }, "evidence": [ { "id": "A0AAA9SKQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SKQ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AB32TCE3-1", "protein_name": "Protein NDRG4 isoform X1", "gene_name": "ndrg4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEGRQVKFINSAKLLRQSGRLCQKQQASRSPSRPPLKSRMGPGLFWNFPSKASCTVPQSLLQTMLLSRMAGMKDQQFTEEKPLLPDSRGQETEMAKGQSVHVLPSATPPPPTARPPKRWHAIAQHWLGLTRRRTSGYFPENCETFVATGDWKEHDIETPYGMLHVVIRGAPKGNKPAILTYHDVGLNHKLCFNSFFQNEDMLEITKHFVVCHVDAPGQHIGAPQMPQGYQYPTMDQLAGMLPSVVQHFGFKSIVGIGVGAGAYILAKFALIFPDLVEGLVLLNIDPNGKGWIDWAATKLSGLTSTLPDTVLTHLFSQEELMSNTEVVQNYRQQINNTINQFNLQLFWNMYNSRRDLEMNRSGSVINAKTLRCPVMLVVGDNAPAEEGVVECNSKLDPTNTTFLKMADSGGMPQITQPGKLTEAFKYFLQGMGYIAYMKDRRMSGGPVPSASMTRLARSRTASLTSAGSVDGSRNRACTHSDSSEGVGQVSHTMEVSC", "length": 497 }, "evidence": [ { "id": "A0AAA9SKQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SKQ0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q55BX3-1", "protein_name": "NDRG-like protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSLNKSIGSVTESPINVVVHNYDNNDPTETRHEVQTKHGKLVCFQKIGSNQSPNMPTIISYHDLGLNHTTCFSPFFNHPNMNHILPYLNIIHIEAPGHEFNAETIPSSQYPSITEMAEDIQYVLDYFKVKVFIGLGAGAGGCILTQYSIFYPRSVVGLVLVGSVIKSFSWLDWVKSWVELTTLPSLKNPTGVRKYLIDHYYADNLEETNPDLLEIIKKEMVLINPDNLYHYVHSFVKRDDIKEEQIKALGCKILLVVGKDSTYKEDIIDLFSQFNPRNSTILQVPDCGILVTAEKPGDIVEPFKLFMQGIGFLLDYYQSHDDAQK", "length": 326 }, "evidence": [ { "id": "A0AAA9SKQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SKQ0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BTG7-1", "protein_name": "Protein NDRG4", "gene_name": "Ndrg4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQISNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEEGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAHLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGSRPQPCAHSDSSEGMGQVNHTMEVSC", "length": 352 }, "evidence": [ { "id": "A0AAA9SKQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SKQ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ULP0-1", "protein_name": "Protein NDRG4", "gene_name": "NDRG4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGSRPQACTHSESSEGLGQVNHTMEVSC", "length": 352 }, "evidence": [ { "id": "A0AAA9SKQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SKQ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "cell projection membrane", "id": "GO:0031253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031253", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "visual learning", "id": "GO:0008542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "negative regulation of platelet-derived growth factor receptor signaling pathway", "id": "GO:0010642", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010642", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell migration", "id": "GO:0014912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell proliferation", "id": "GO:0048662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048662", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "cell migration involved in heart development", "id": "GO:0060973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060973", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "regulation of endocytic recycling", "id": "GO:2001135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001135", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" }, { "name": "vesicle docking", "id": "GO:0048278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048278", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJK9-1", "uniprot_ac": "A0AAA9SJK9", "uniprot_id": "A0AAA9SJK9_BOVIN", "mass": { "chemical_mass": 36042.0, "monoisotopic_mass": 36042.0 }, "refseq": { "ac": "XP_015327145", "name": "WD repeat-containing protein 5B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327145" }, "gene_names": [ { "name": "WDR5B", "type": "recommended", "evidence": [ { "id": "A0AAA9SJK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9" } ] }, { "name": "WDR5B", "type": "synonym", "evidence": [ { "id": "XP_015327145", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327145" } ] } ], "protein_names": [ { "name": "WD repeat domain 5B", "type": "synonym", "evidence": [ { "id": "A0AAA9SJK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 5B", "type": "synonym", "evidence": [ { "id": "XP_015327145", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327145" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR5B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9", "locus": { "chromosome": "1", "start_pos": 66863022, "end_pos": 66866455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054326", "url": "https://www.ensembl.org/id/ENSBTAG00000054326" } ] } } ], "crossref": [ { "id": "A0AAA9SJK9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJK9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054326", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054326", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100138335", "url": "https://www.ncbi.nlm.nih.gov/gene/100138335", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138335", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138335", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWZ5", "url": "https://www.orthodb.org/?gene=A0A3Q1LWZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22847", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22847", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22847:SF516", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22847:SF516", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015327145", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327145", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWZ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTEQSGNAKAEPALPSSANQSKPVSEKPNYALKFTLEGHTEAVSSVKFSPNGEWLASSSADKVIIIWGAYDGKYEKTLKGHNLEISDVAWSSDSSRLVSASDDKTLKIWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDESVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGVCRIWDAASGQCLKALVDDDNPPVSFVKFSPNGKYILIATLDNTLKLWDYSRGRCLKTYTGHKNEKYCVFASFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENIIASAALGNDKTVKLWTSTY", "length": 330, "header": "tr|A0AAA9SJK9-1|A0AAA9SJK9_BOVIN Isoform 1 of WD repeat domain 5B OS=Bos taurus OX=9913 GN=WDR5B PE=3 SV=1 CANONICAL=A0AAA9SJK9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9/entry#A0A3Q1LWZ5-1", "sequence": { "sequence": "MTTEQSGNAKAEPALPSSANQSKPVSEKPNYALKFTLEGHTEAVSSVKFSPNGEWLASSSADKVIIIWGAYDGKYEKTLKGHNLEISDVAWSSDSSRLVSASDDKTLKIWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDESVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGVCRIWDAASGQCLKALVDDDNPPVSFVKFSPNGKYILIATLDNTLKLWDYSRGRCLKTYTGHKNEKYCVFASFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVLTKQDD", "length": 305, "header": "tr|A0A3Q1LWZ5-1|A0AAA9SJK9_BOVIN Computationally mapped isoform of WD repeat domain 5B OS=Bos taurus OX=9913 GN=WDR5B PE=3 SV=2 CANONICAL=A0AAA9SJK9-1" }, "locus": { "chromosome": "1", "start_pos": 66865795, "end_pos": 66864152, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071769.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071769.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061985.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061985.2" } ] } }, { "isoform_ac": "A0AAA9SJK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9/entry#A0AAA9SJK9-1", "sequence": { "sequence": "MTTEQSGNAKAEPALPSSANQSKPVSEKPNYALKFTLEGHTEAVSSVKFSPNGEWLASSSADKVIIIWGAYDGKYEKTLKGHNLEISDVAWSSDSSRLVSASDDKTLKIWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDESVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGVCRIWDAASGQCLKALVDDDNPPVSFVKFSPNGKYILIATLDNTLKLWDYSRGRCLKTYTGHKNEKYCVFASFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENIIASAALGNDKTVKLWTSTY", "length": 330, "header": "tr|A0AAA9SJK9-1|A0AAA9SJK9_BOVIN Isoform 1 of WD repeat domain 5B OS=Bos taurus OX=9913 GN=WDR5B PE=3 SV=1 CANONICAL=A0AAA9SJK9-1" }, "locus": { "chromosome": "1", "start_pos": 66865795, "end_pos": 66864806, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113503.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113503.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082791.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082791.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138335", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138335", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Set1C/COMPASS complex", "id": "GO:0048188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048188", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK9" }, { "id": "PF25175", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25175" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WDR5-like beta-propeller", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 327, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 20, "end_pos": 22 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK08-1", "uniprot_ac": "A0AAA9SK08", "uniprot_id": "A0AAA9SK08_BOVIN", "mass": { "chemical_mass": 36677.0, "monoisotopic_mass": 36677.0 }, "refseq": {}, "gene_names": [ { "name": "DDRGK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SK08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ] } ], "protein_names": [ { "name": "DDRGK domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SK08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDRGK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08", "locus": { "chromosome": "13", "start_pos": 52014649, "end_pos": 52002925, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013753", "url": "https://www.ensembl.org/id/ENSBTAG00000013753" } ] } } ], "crossref": [ { "id": "A0AAA9SK08", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK08", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013753", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013753", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFTRECN", "url": "https://omabrowser.org/oma/group/EFTRECN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZ83", "url": "https://www.orthodb.org/?gene=A0A3Q1LZ83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MK36", "url": "https://www.orthodb.org/?gene=F1MK36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48176:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48176:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZ83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK36", "url": "https://www.uniprot.org/uniprotkb/F1MK36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK36-1", "url": "https://www.uniprot.org/uniprotkb/F1MK36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRWLQQTLSLPLKNTHVCMHPPPCFASLPEGRVSCQAAQEPLHNEEVPAAAGRVARPQPLEPEEQRAAGRPRRRRDLGSRLQAQRRAQRVAWADENEEEAIIQAQEEEDIEKPVETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQAQREHEEYLKLKETFVVEEEGVGETMTEEQSHSFLAEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWGRETPAQAPA", "length": 319, "header": "tr|A0AAA9SK08-1|A0AAA9SK08_BOVIN Isoform 1 of DDRGK domain-containing protein 1 OS=Bos taurus OX=9913 GN=DDRGK1 PE=3 SV=1 CANONICAL=A0AAA9SK08-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08/entry#A0A3Q1LZ83-1", "sequence": { "sequence": "MVSPVVYLVVAALLVGLILFLTRGRGRAAAAAQEPLHNEEVPAAAGRVARPQPLEPEEQRAAGRPRRRRDLGSRLQAQRRAQRVAWADENEEEAIIQAQEEEDIEKPVETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQAQREHEEYLKLKETFVVEEEGVGETMTEEQVELFSSQDTINRIQDLLAEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWGRETPAQAPA", "length": 288, "header": "tr|A0A3Q1LZ83-1|A0AAA9SK08_BOVIN Computationally mapped isoform of DDRGK domain-containing protein 1 OS=Bos taurus OX=9913 GN=DDRGK1 PE=3 SV=1 CANONICAL=A0AAA9SK08-1" }, "locus": { "chromosome": "13", "start_pos": 52014521, "end_pos": 52004100, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072069.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072069.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066136.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066136.1" } ] } }, { "isoform_ac": "A0AAA9SK08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08/entry#A0AAA9SK08-1", "sequence": { "sequence": "MRWLQQTLSLPLKNTHVCMHPPPCFASLPEGRVSCQAAQEPLHNEEVPAAAGRVARPQPLEPEEQRAAGRPRRRRDLGSRLQAQRRAQRVAWADENEEEAIIQAQEEEDIEKPVETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQAQREHEEYLKLKETFVVEEEGVGETMTEEQSHSFLAEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWGRETPAQAPA", "length": 319, "header": "tr|A0AAA9SK08-1|A0AAA9SK08_BOVIN Isoform 1 of DDRGK domain-containing protein 1 OS=Bos taurus OX=9913 GN=DDRGK1 PE=3 SV=1 CANONICAL=A0AAA9SK08-1" }, "locus": { "chromosome": "13", "start_pos": 52014521, "end_pos": 52004647, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123807.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123807.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084189.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084189.1" } ] } }, { "isoform_ac": "A0AAA9SXR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08/entry#A0AAA9SXR6-1", "sequence": { "sequence": "AQELAAQEPLHNEEVPAAAGRVARPQPLEPEEQRAAGRPRRRRDLGSRLQAQRRAQRVAWADENEEEAIIQAQEEEDIEKPVETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQAQREHEEYLKLKETFVVEEEGVGETMTEEQSHSFLAEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWGRETPAQAPA", "length": 287, "header": "tr|A0AAA9SXR6-1|A0AAA9SXR6_BOVIN Computationally mapped isoform of DDRGK domain-containing protein 1 OS=Bos taurus OX=9913 GN=DDRGK1 PE=3 SV=1 CANONICAL=A0AAA9SK08-1" }, "locus": { "chromosome": "13", "start_pos": 52014521, "end_pos": 52003124, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099531.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099531.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090160.1" } ] } }, { "isoform_ac": "F1MK36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08/entry#F1MK36-1", "sequence": { "sequence": "MVSPVVYLVVAALLVGLILFLTRGRGRAAAAAQEPLHNEEVPAAAGRVARPQPLEPEEQRAAGRPRRRRDLGSRLQAQRRAQRVAWADENEEEAIIQAQEEEDIEKPVETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQAQREHEEYLKLKETFVVEEEGVGETMTEEQSHSFLAEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWGRETPAQAPA", "length": 313, "header": "tr|F1MK36-1|F1MK36_BOVIN Computationally mapped isoform of DDRGK domain-containing protein 1 OS=Bos taurus OX=9913 GN=DDRGK1 PE=3 SV=1 CANONICAL=A0AAA9SK08-1" }, "locus": { "chromosome": "13", "start_pos": 52014521, "end_pos": 52004100, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018273.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018273.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018273.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018273.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z3L3-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "DDRGK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDAVLLAVVAALLAVLLFFATLFRRSAPAADEEHQQDVAAAVRPRPYVEERGDGMPRRRRNLGNRMMAQRRAQQAEEWVEEEDDAEEVPELQVTGKIGAKKQRKLEEKQARKAQREAEEAEREERRKLESKREEERRKEEERIRLEEERQEEEKRKAKEEEEKREYEEYLKLKESFVVEEEGVEESMTEEETRSFLKEFIEYIKKTKVIQLEDLASHMGLRTQDAINRIQDLMADGTLTGVIDDRGKFIYITPEEMAAVAQFIKQRGRVSIAELVQASNSLINLQPDSQAVAPTMA", "length": 296 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZAS9-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "Ddrgk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVVGGAWRSGSRRRAGVAARLSVVMVGPWVYLVAAVLLIGLILFLTRSRGRAAAADGEPLHNEEERTGAGQVARSWPQESEEQRTGGRPRRRRDLGSRLQAQRRAQRVTWEEVDENEGEAAVPAQEEEGVEKPAEVHPTGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLKEEQKEEEERKAREEQARREHEEYLKLKEAFVVEEEGVSETMTEEQSHSFLTEFINYIKQSKVVLLEDLAFQMGLRTQDAINRIQDLLTEGTLTGVIDDRGKFIYITPEELAAVASFIRQRGRVSITELAQASNSLISWGQDLPAQASV", "length": 339 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55CM7-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGDTYSLVLVAGYLSIFLFIGAIGYFYLSKPRIPSSNVNEQQQQQQQQQQQQQQPQINIEDEPQQRGGIGRMNLRNRRQPIINQRDEDTESSGSDSDNSTNSDNYDDDNGQEGEGEDIGVVAPGIVSNRSGKKIGKKKLEKLKLKDEKRKAREYQEYLREEKKKTDLEKEEALKEKRLEEKENEKLRKEEEERIRIEKERKEDEEYNLLKSQISLQESGITKNEDYDKSLLQLFIKYLKEHKICLLEDIAIEFNIKTNEVIDRIKTLDKQGLISGVIDDRGKFIYITKEEMEAVAKFVNKKGRVNIEQIALESNRLIDFSKKVVDNNDQDPVDTN", "length": 335 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q80WW9-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "Ddrgk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGPWVYLVAAVLLIGLILFLTRSRGRAAAADGEPLHNEEERAGAGQVGRSLPQESEEQRTGSRPRRRRDLGSRLQAQRRAQRVAWEDGDENVGQTVIPAQEEEGIEKPAEVHPTGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLKEEQKEEEERKAQEEQARREHEEYLKLKEAFVVEEEGVSETMTEEQSHSFLTEFINYIKKSKVVLLEDLAFQMGLRTQDAINRIQDLLTEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLISWGQDLPAQASA", "length": 315 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q94C53-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEEIFALIVSMILIVAVIPLFFWKRRRDARSREEVAEPPQVQPRENVARAGGGRRMRRRPAASGASSSTSNVQENGSGSEDEDEDEAGGTQARASKKKEKKRQEREAQRQAEEATRESRNTKQDWYAEMRRKKDEEREAEELKLEEEEKARQAKEEEAAALEFDKWKGEFSVDAEGTTEEVQGGNQDLLSEFVEYIKKQKCVPLEDLAAEFHLRTQECINRIASLESIGRLSGVMDDRGKYIYISMEEMNAVADYIKRQGRVSISHLASKSNQFIDLEPKVQHQLTEEISGMEEISVS", "length": 298 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q96HY6-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "DDRGK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAPVWYLVAAALLVGFILFLTRSRGRAASAGQEPLHNEELAGAGRVAQPGPLEPEEPRAGGRPRRRRDLGSRLQAQRRAQRVAWAEADENEEEAVILAQEEEGVEKPAETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTITGVIDDRGKFIYITPEELAAVANFIRQRGRVSIAELAQASNSLIAWGRESPAQAPA", "length": 314 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VDD1-1", "protein_name": "DDRGK domain-containing protein 1", "gene_name": "Ddrgk1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDLIILVGIAVALLVVIVTLYLLQKKNAAPETKVAAAPQRGVPQRAQEGVPRRAQIARNQRNRLRQNVPAAPVAAAAGALPAAGDSDHEDEGQVDGDEARVPQGAVLDEKMGAKKRAKMEAKEQKRLQREQELHDREQRKVKEAKEEAERKQQEDLEAEAERKRVDAERLAKEERERKEHEEYLKMKAAFSVEEEGFEEGDADDQDNLLADFIQYIRDNKVVVLEDLAVAFKLKTQQVIDRIQNLQADGTLTGVIDDRGKFIYVSEKELLAVAKFIKQRGRVSIAELAESSNNLINLTPISAGGGEASS", "length": 309 }, "evidence": [ { "id": "A0AAA9SK08", "url": "https://omabrowser.org/oma/group/A0AAA9SK08/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "protein localization to endoplasmic reticulum", "id": "GO:0070972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070972", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "cartilage development", "id": "GO:0051216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "negative regulation of PERK-mediated unfolded protein response", "id": "GO:1903898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "negative regulation of IRE1-mediated unfolded protein response", "id": "GO:1903895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903895", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of protein localization to endoplasmic reticulum", "id": "GO:1905552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "protein K69-linked ufmylation", "id": "GO:1990592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990592", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "regulation of intracellular estrogen receptor signaling pathway", "id": "GO:0033146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of plasma cell differentiation", "id": "GO:1900100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900100", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "positive regulation of reticulophagy", "id": "GO:0140501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140501", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin-like protein ligase binding", "id": "GO:0044389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044389", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" }, { "name": "UFM1-modified protein reader activity", "id": "GO:0141185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141185", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMB5-1", "uniprot_ac": "A0AAA9SMB5", "uniprot_id": "A0AAA9SMB5_BOVIN", "mass": { "chemical_mass": 377571.0, "monoisotopic_mass": 377571.0 }, "refseq": { "ac": "XP_005201486", "name": "golgin subfamily B member 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201486" }, "gene_names": [ { "name": "GOLGB1", "type": "recommended", "evidence": [ { "id": "A0AAA9SMB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5" } ] }, { "name": "GOLGB1", "type": "synonym", "evidence": [ { "id": "XP_005201486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201486" } ] } ], "protein_names": [ { "name": "Golgin B1", "type": "synonym", "evidence": [ { "id": "A0AAA9SMB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#names_and_taxonomy" } ] }, { "name": "golgin subfamily B member 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201486" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLGB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5", "locus": { "chromosome": "1", "start_pos": 66150780, "end_pos": 66226752, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008862", "url": "https://www.ensembl.org/id/ENSBTAG00000008862" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008862", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008862", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532923", "url": "https://www.ncbi.nlm.nih.gov/gene/532923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532923", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532923", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR18887", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18887", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18887:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18887:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005201486", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201486", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6J0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6J0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6J0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6J0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJE7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T268", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T268", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T268-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T268-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKZ5", "url": "https://www.uniprot.org/uniprotkb/E1BKZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNTLSIQLCDTSQSLRENQQHYSDLFNHCAVLEKQVQELQAVSEKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3273, "header": "tr|A0AAA9SMB5-1|A0AAA9SMB5_BOVIN Isoform 1 of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=1 CANONICAL=A0AAA9SMB5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#A0A3Q1M6J0-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNTLSIQLCDTSQSLRENQQHYSDLFNHCAVLEKQVQELQAVSEKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3194, "header": "tr|A0A3Q1M6J0-1|A0AAA9SMB5_BOVIN Computationally mapped isoform of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=2 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069890.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069890.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065607.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065607.2" } ] } }, { "isoform_ac": "A0A3Q1MAP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#A0A3Q1MAP7-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQFSQLLEEKNTLSIQLCDTSQSLRENQQHYSDLFNHCAVLEKQVQELQAVSEKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3227, "header": "tr|A0A3Q1MAP7-1|A0AAA9SMB5_BOVIN Computationally mapped isoform of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=2 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079358.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079358.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067695.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067695.2" } ] } }, { "isoform_ac": "A0A3Q1MJE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#A0A3Q1MJE7-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3180, "header": "tr|A0A3Q1MJE7-1|A0AAA9SMB5_BOVIN Computationally mapped isoform of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=1 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081026.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081026.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070895.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070895.1" } ] } }, { "isoform_ac": "A0AAA9SMB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#A0AAA9SMB5-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNTLSIQLCDTSQSLRENQQHYSDLFNHCAVLEKQVQELQAVSEKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3273, "header": "tr|A0AAA9SMB5-1|A0AAA9SMB5_BOVIN Isoform 1 of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=1 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103583.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103583.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085036.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085036.1" } ] } }, { "isoform_ac": "A0AAA9T268-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#A0AAA9T268-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNTLSIQLCDTSQSLRENQQHYSDLFNHCAVLEKQVQELQAVSEKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3190, "header": "tr|A0AAA9T268-1|A0AAA9T268_BOVIN Computationally mapped isoform of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=1 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130946.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130946.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090723.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090723.1" } ] } }, { "isoform_ac": "A0AAA9T5L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#A0AAA9T5L8-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNTLSIQLCDTSQSLRENQQHYSDLFNHCAVLEKQVQELQAVSEKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3232, "header": "tr|A0AAA9T5L8-1|A0AAA9T5L8_BOVIN Computationally mapped isoform of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=1 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099894.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099894.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094069.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094069.1" } ] } }, { "isoform_ac": "E1BKZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5/entry#E1BKZ5-1", "sequence": { "sequence": "MLSRLSGLANVVLHELSGDDTDENMRASLEPELPQESDMEFNDRTQEDVLERLAYVEQLVVELKEIIRQKDAELQQKDEVLQEERKAADNKIKKLKLHAKAKLTSLNKHIEEMKAQGGTVLSTEPQSEEQLSKHDKSSTEEEIEVEKIKHKLQEKEELITSLQAQLTQAQANQATQSAKSSTEMEEFLMMKKQLQEKEELISTLQTQLSQTQAEQAAQLSSMQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEEALLGRTQVVDLLQQELTAAEQRNQILCQQLQQMEAELSTLRNTIETERQESKVLMEKMELEVAERKLSFHNLQEEMHHLLEQLEQAGQAQAELQSRHSALEQKHNAEMEEKTSHILSLRKSEQELQSACDALKDQNSKLLQDKNEQAAHSAQVIQQLEDQLQQKSEEINQFLNKPTLLKHEIASQTCSPDVSHEGTQAVTEESIAFLQKRVVELENEKGALLLNSVELEELKAENEKLSSQITLLESQKRTGEVDREVHEVSMVDITRLNKSSFSAEESGQDALENTFTQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEGDPEFLDQKEMKQIESEGIPPVKMTVLLEDTGQHFPPTPDKESSRTTTEKGEQMSPEHQHRPSEEISLTYTGVELKSAEQDNDDKPSSAAPGICQCHQDELERLKGQVLELEVNLHKAEEIYEKNLDEKAKEISMLTQLIEEFKKNAENTNNAFTALSEERDQLLAQVKELCVVTELRAQVQQLEVSLAEAERQRRLDYESQTAHHDLLTEQIHSLTIEAKSKDVKIEVLQNELDGVQVQFSEQSTLIKSLQSQLQKKESEVLEGAEREREVSNKVEELSQALSQKELEIAKMDQLLLEKKKDVEILQQTIEEKDQQVTELSFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEETKKEQMEEDKEIVSSIKQNYDELSPAGLISKEELQRELDLVKKESEQRKRKLQAALINRKELLQKVSRLEEELAKVKDEPSKEILLHESERREVEEDKESKEDLEKRVTSKCQEIEMSLKLIISEKEMELEHIRKDLEEKAAIEEQLQAVVKQMNQNLQEKTNQIDLLQAEVVENQAIIQKLTTGNKDAGDGNSAAPVKEAVAISPLGAGSGEHWKPELEEKIVDLEKEKEQLQKKLQEVLTSRKVILKKAQEKERHLREELKQQKYDYNRLQEQFDEQSKENENIGDQLKQLQIQVQESMDRKLPGSGQQEPGAATQGLEEPLFKTTKQQPVQSVSESDLHPDWPSHLGDTDALQGNAAIAQIKTQLKEIEAEKEELELKVNSTINELTKKSEEVFQLQEQINKQDLEIQSLKAESCEAEAHAETLRQKLESSQLEIAGLEQLRDLKPELDELQKLISKKEEEVRYLSGLLSEKETALTKVQTEITEQEDLVKALRTQLEMQAKEHDEKIKQFQVELCELKQKPEETGEESKAKQQIQRKLQAALISRKEALKENKGLQEELSLARDTIEHLTKSLADVENQVSAQNREKDVFLGKLAVLQEERDKLIAEVDRSLMENQSLSGSCESLKLALEGLTEDKENLMKEIESLKCSKIAESTEWQEKHQELQKEYEILLQSYENVSNEAERIQHVVETVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENERLRAEIHPAGDTSKDSMEALLSSNSNMKEELERVKTEYKTLSEEFKALKAEKDSLSEEVQHLKHQIEDNVSKQASLEPTEKHDNQMAVTEEATPSAPGEADEQDSPGMNTRPENLESTLSENSAKPDICENVSLHDEINNYLQQIDQLKERITELEEGRQKDKDFSQNLENERDALLSQIAAKDGELKMLQEEVTKINLLNQQTQEELARVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNELLESEMQNLKKCVSELEEEKQQLVKEKTKVESEIRKEYMEKIQGAQKGPGNKSHAKELQELLKEKQQEVKQLQTDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQANEHRKKAELELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESIKSQMKQKDEDLERRLEQVEEKHLKEKKNMQEKLDALRREKVHLEETFGEVQVTLNKKDKEVKQLQENLDSTVAQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQTKEEEIRLKEENCSVLKDQLRQMSIHMEELKINISRLEHDKQMWESKAQTEVQIQQKVCDTLQGENKELLSQLEETQNLYRSSQDDLAKLESELKILRDQSTDLNNSLEKFKENKENLEGIIKQKEADIQNCKFSYEQLETDLQASRQLTSRLHEEINMKEQKIISLLSAKEQAVQVAVAELHRQHDKEIKELENLLSQEEEENTVLEEENKKVVDRTNQLMEALKNIKKENMQQKAQLNSFVKSMSSLQDDRDRIVSDYQQLEERHLSVILEKDQLIQDAATENNKLKEEIRCLRSHMDDLNSENAKLNAELIQYREDLNQVLSKKDCQQKQLLEAQLQQVKEVKGEYAKLEAKLKESEEAREELQRSSLALQEEKQDLAKETESLKVSLSQLKKQLTALQEEGTLGIFQAQLKAKEEEVQKLSTVFSSSQKRVMELEEELVNVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKDLTAQIQSFGRSMSSLQNSRDQAHEELEELKRKYEASLKELAQLREQGLISRERDVLVSKAAFPVISTEDNSLPHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDRLLSELEKLRKSEDGRQRSPAPPATSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELRPLKAQLQEYQDKTKTFQIMQEELKQENLSWQHELHQLRIEKNSWEMQERRMKEQYFMAIADKDQQLSHLQNLVRELRSSSSQTETHKVQYQRQASPETSVSLNGSQNLVYETEHLRTQLNDSLKEIHQKELRIQQLNSKGPLNIDVAPGAPQEKNGGHRKGDAEELSEPQLSFSEAQKQLCNTKQEMNELRKLLEEERDQRAAAEAALSMAEEQIRRLEHGEWDSPRSPIIGSCGSQEQALLIDLTSSSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAVYFLMVHVLLVLCLTGHL", "length": 3221, "header": "tr|E1BKZ5-1|A0AAA9SMB5_BOVIN Computationally mapped isoform of Golgin B1 OS=Bos taurus OX=9913 GN=GOLGB1 PE=4 SV=4 CANONICAL=A0AAA9SMB5-1" }, "locus": { "chromosome": "1", "start_pos": 66215009, "end_pos": 66151784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011669.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011669.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011669.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011669.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1800, "start_aa": "Thr", "end_pos": 1800, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1800", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532923", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532923", "resource": "KEGG Pathway" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1336, "end_pos": 1338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1572, "end_pos": 1574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1634, "end_pos": 1636, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1776, "end_pos": 1778, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1838, "end_pos": 1840, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1944, "end_pos": 1946, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2013, "end_pos": 2015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2242, "end_pos": 2244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2263, "end_pos": 2265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2335, "end_pos": 2337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2706, "end_pos": 2708, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2952, "end_pos": 2954, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3028, "end_pos": 3030, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3045, "end_pos": 3047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1800 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1336, "end_pos": 1338 }, { "start_pos": 1572, "end_pos": 1574 }, { "start_pos": 1634, "end_pos": 1636 }, { "start_pos": 1776, "end_pos": 1778 }, { "start_pos": 1838, "end_pos": 1840 }, { "start_pos": 1944, "end_pos": 1946 }, { "start_pos": 2013, "end_pos": 2015 }, { "start_pos": 2242, "end_pos": 2244 }, { "start_pos": 2263, "end_pos": 2265 }, { "start_pos": 2335, "end_pos": 2337 }, { "start_pos": 2706, "end_pos": 2708 }, { "start_pos": 2952, "end_pos": 2954 }, { "start_pos": 3028, "end_pos": 3030 }, { "start_pos": 3045, "end_pos": 3047 }, { "start_pos": 543, "end_pos": 545 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SID7-1", "uniprot_ac": "A0AAA9SID7", "uniprot_id": "A0AAA9SID7_BOVIN", "mass": { "chemical_mass": 21321.0, "monoisotopic_mass": 21321.0 }, "refseq": { "ac": "XP_005219950", "name": "small ribosomal subunit protein mS23 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219950" }, "gene_names": [ { "name": "MRPS23", "type": "recommended", "evidence": [ { "id": "A0AAA9SID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ] }, { "name": "MRPS23", "type": "synonym", "evidence": [ { "id": "XP_005219950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219950" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein mS23", "type": "recommended", "evidence": [ { "id": "A0AAA9SID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7/entry#names_and_taxonomy" } ] }, { "name": "small ribosomal subunit protein mS23 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005219950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219950" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPS23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7", "locus": { "chromosome": "19", "start_pos": 8654486, "end_pos": 8661095, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012366", "url": "https://www.ensembl.org/id/ENSBTAG00000012366" } ] } } ], "crossref": [ { "id": "A0AAA9SID7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SID7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012366", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012366", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23701", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23701", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515228", "url": "https://www.ncbi.nlm.nih.gov/gene/515228", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M7M3", "url": "https://www.orthodb.org/?gene=A0A3Q1M7M3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MZW1", "url": "https://www.orthodb.org/?gene=F1MZW1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15925", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15925", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15925:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15925:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10484", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10484", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005219950", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219950", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7M3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7M3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SID7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZW1", "url": "https://www.uniprot.org/uniprotkb/F1MZW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZW1-1", "url": "https://www.uniprot.org/uniprotkb/F1MZW1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSRLETVGSIFTRTRDLIRAGVLKEKPLWFDVYNAFPPLREPVFRRPRLRYGKAKSPTQDIFYHEDQIRAKFYAAYGSGPKAFDLFNPNFKSTCQRFVEKYIELQKLGETDEEKLFVEAGKALLAEGVILRRVEKARTEGSQVSRKSESMGVESQTALEENPPLKEVPQAQHLESPGEESKGLSPP", "length": 188, "header": "tr|A0AAA9SID7-1|A0AAA9SID7_BOVIN Isoform 1 of Small ribosomal subunit protein mS23 OS=Bos taurus OX=9913 GN=MRPS23 PE=3 SV=1 CANONICAL=A0AAA9SID7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M7M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7/entry#A0A3Q1M7M3-1", "sequence": { "sequence": "MRRWINPEHCLVGLEFGNILPSSRTRDLIRAGVLKEKPLWFDVYNAFPPLREPVFRRPRLRYGKAKSPTQDIFYHEDQIRAKFYAAYGSGPKAFDLFNPNFKSTCQRFVEKYIELQKLGETDEEKLFVEAGKALLAEGVILRRVEKARTQQEGSQVSRKSESMGVESQTALEENPPLKEVPQAQHLESPGEESKGLSPP", "length": 199, "header": "tr|A0A3Q1M7M3-1|A0AAA9SID7_BOVIN Computationally mapped isoform of Small ribosomal subunit protein mS23 OS=Bos taurus OX=9913 GN=MRPS23 PE=3 SV=2 CANONICAL=A0AAA9SID7-1" }, "locus": { "chromosome": "19", "start_pos": 8659471, "end_pos": 8655410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078309.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078309.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069834.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069834.2" } ] } }, { "isoform_ac": "A0AAA9SID7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7/entry#A0AAA9SID7-1", "sequence": { "sequence": "MAGSRLETVGSIFTRTRDLIRAGVLKEKPLWFDVYNAFPPLREPVFRRPRLRYGKAKSPTQDIFYHEDQIRAKFYAAYGSGPKAFDLFNPNFKSTCQRFVEKYIELQKLGETDEEKLFVEAGKALLAEGVILRRVEKARTEGSQVSRKSESMGVESQTALEENPPLKEVPQAQHLESPGEESKGLSPP", "length": 188, "header": "tr|A0AAA9SID7-1|A0AAA9SID7_BOVIN Isoform 1 of Small ribosomal subunit protein mS23 OS=Bos taurus OX=9913 GN=MRPS23 PE=3 SV=1 CANONICAL=A0AAA9SID7-1" }, "locus": { "chromosome": "19", "start_pos": 8660132, "end_pos": 8655410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128899.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128899.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083510.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083510.1" } ] } }, { "isoform_ac": "F1MZW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7/entry#F1MZW1-1", "sequence": { "sequence": "GQETQEGGLGSRVTLVRTRDLIRAGVLKEKPLWFDVYNAFPPLREPVFRRPRLRYGKAKSPTQDIFYHEDQIRAKFYAAYGSGPKAFDLFNPNFKSTCQRFVEKYIELQKLGETDEEKLFVEAGKALLAEGVILRRVEKARTQQEGSQVSRKSESMGVESQTALEENPPLKEVPQAQHLESPGEESKGLSPP", "length": 192, "header": "tr|F1MZW1-1|A0AAA9SID7_BOVIN Computationally mapped isoform of Small ribosomal subunit protein mS23 OS=Bos taurus OX=9913 GN=MRPS23 PE=3 SV=2 CANONICAL=A0AAA9SID7-1" }, "locus": { "chromosome": "19", "start_pos": 8661090, "end_pos": 8655410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016409.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016409.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016409.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016409.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SID7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SID7" }, { "id": "PF10484", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10484" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Small ribosomal subunit protein mS23 conserved", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 129, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJD4-1", "uniprot_ac": "A0AAA9SJD4", "uniprot_id": "A0AAA9SJD4_BOVIN", "mass": { "chemical_mass": 38411.0, "monoisotopic_mass": 38411.0 }, "refseq": {}, "gene_names": [ { "name": "PITPNC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ] } ], "protein_names": [ { "name": "Cytoplasmic phosphatidylinositol transfer protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4/entry#names_and_taxonomy" } ] }, { "name": "Mammalian rdgB homolog beta", "type": "synonym", "evidence": [ { "id": "A0AAA9SJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4/entry#names_and_taxonomy" } ] }, { "name": "Retinal degeneration B homolog beta", "type": "synonym", "evidence": [ { "id": "A0AAA9SJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes. Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MGY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGY9#function" }, { "database": "UniProtKB", "id": "ARBA00055461", "url": "https://www.uniprot.org/uniprotkb/ARBA00055461#function" }, { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PITPNC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4", "locus": { "chromosome": "19", "start_pos": 49220295, "end_pos": 49484333, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044065", "url": "https://www.ensembl.org/id/ENSBTAG00000044065" } ] } } ], "crossref": [ { "id": "A0AAA9SJD4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJD4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08890", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08890", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10658", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10658", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10658:SF55", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10658:SF55", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02121", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02121", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "36435", "url": "https://www.rhea-db.org/rhea/36435", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38691", "url": "https://www.rhea-db.org/rhea/38691", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MGY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLKEYRICMPLTVDEYRIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDSIFDNEAKDLEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGVFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPRDRPRKKSAPETLTLPDPEKKATLNLPGIHSSDKPCRPKSE", "length": 332, "header": "tr|A0AAA9SJD4-1|A0AAA9SJD4_BOVIN Isoform 1 of Cytoplasmic phosphatidylinositol transfer protein 1 OS=Bos taurus OX=9913 GN=PITPNC1 PE=3 SV=1 CANONICAL=A0AAA9SJD4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4/entry#A0A3Q1MGY9-1", "sequence": { "sequence": "MLLKEYRICMPLTVDEYRIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDSIFDNEAKDLEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDDVREYEKNMHEQTNIKVCNQHSSTVDDIESQAQTST", "length": 268, "header": "tr|A0A3Q1MGY9-1|A0AAA9SJD4_BOVIN Computationally mapped isoform of Cytoplasmic phosphatidylinositol transfer protein 1 OS=Bos taurus OX=9913 GN=PITPNC1 PE=3 SV=2 CANONICAL=A0AAA9SJD4-1" }, "locus": { "chromosome": "19", "start_pos": 49484080, "end_pos": 49221610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085436.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085436.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068309.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068309.2" } ] } }, { "isoform_ac": "A0AAA9SJD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4/entry#A0AAA9SJD4-1", "sequence": { "sequence": "MLLKEYRICMPLTVDEYRIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDSIFDNEAKDLEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGVFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPRDRPRKKSAPETLTLPDPEKKATLNLPGIHSSDKPCRPKSE", "length": 332, "header": "tr|A0AAA9SJD4-1|A0AAA9SJD4_BOVIN Isoform 1 of Cytoplasmic phosphatidylinositol transfer protein 1 OS=Bos taurus OX=9913 GN=PITPNC1 PE=3 SV=1 CANONICAL=A0AAA9SJD4-1" }, "locus": { "chromosome": "19", "start_pos": 49484080, "end_pos": 49221299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107794.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107794.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086380.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086380.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" }, { "name": "phosphatidylinositol transfer activity", "id": "GO:0008526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008526", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" }, { "name": "phosphatidic acid transfer activity", "id": "GO:1990050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" }, { "name": "phosphatidylglycerol binding", "id": "GO:1901611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901611", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" }, { "name": "phosphatidic acid binding", "id": "GO:0070300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" }, { "name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "id": "GO:1902635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36435", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MUP9-1" ], "evidence": [ { "id": "36435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36435" } ] }, { "id": "38691", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38691", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38691" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJD4" }, { "id": "PF02121", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02121" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphatidylinositol transfer protein N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 243, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJG8-1", "uniprot_ac": "A0AAA9SJG8", "uniprot_id": "A0AAA9SJG8_BOVIN", "mass": { "chemical_mass": 44143.0, "monoisotopic_mass": 44143.0 }, "refseq": { "ac": "XP_005204863", "name": "zinc finger protein 684 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204863" }, "gene_names": [ { "name": "ZNF684", "type": "recommended", "evidence": [ { "id": "A0AAA9SJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ] }, { "name": "ZNF684", "type": "synonym", "evidence": [ { "id": "XP_005204863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204863" } ] } ], "protein_names": [ { "name": "Zinc finger protein 684", "type": "synonym", "evidence": [ { "id": "A0AAA9SJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 684 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204863", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204863" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1MM01", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM01#function" }, { "database": "UniProtKB", "id": "F1MR89", "url": "https://www.uniprot.org/uniprotkb/F1MR89#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF684", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8", "locus": { "chromosome": "3", "start_pos": 105572886, "end_pos": 105644539, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000533", "url": "https://www.ensembl.org/id/ENSBTAG00000000533" } ] } } ], "crossref": [ { "id": "A0AAA9SJG8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000533", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000533", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112441496", "url": "https://www.ncbi.nlm.nih.gov/gene/112441496", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112441496", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441496", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DCPLIDE", "url": "https://omabrowser.org/oma/group/DCPLIDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MR89", "url": "https://www.orthodb.org/?gene=F1MR89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005204863", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204863", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM01", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM01-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MR89", "url": "https://www.uniprot.org/uniprotkb/F1MR89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MR89-1", "url": "https://www.uniprot.org/uniprotkb/F1MR89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MINFKGSVTLQDVAVEFTPEEWQLLDCDQRTLYWDVMLENFRNLISVGTGCPVTETTVIFKVEQGQGPWMVEGENSRWSSPEADCPLVDESDKHQKSKDNFLNSILFMFDKILTVERLHGYNMSTSLNPTRKKSYKCKSYGKSLQPTLDFHNYNRCYNGEHADECNECGKAFKKKFNFIRREKNHTRKKLFECNNCGKAYSSKAHLATHQKIHNRERPFVCSDCGKAFTHKAQLVVHQRLHTGEKPYECSQCGKSFTWNSSFNQHMKSHTLENSFECKECGKTFRYSSSLYKHSKFHTGEKPYQCIVCGKAFGNSSVLVTHQRIHTGEKPYGCIKCGKAFIKKSHLLRHQITHTGERPYECSKCGKPFSQKSNLIVHQKIHM", "length": 382, "header": "tr|A0AAA9SJG8-1|A0AAA9SJG8_BOVIN Isoform 1 of Zinc finger protein 684 OS=Bos taurus OX=9913 GN=ZNF684 PE=3 SV=1 CANONICAL=A0AAA9SJG8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MM01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8/entry#A0A3Q1MM01-1", "sequence": { "sequence": "MLENFRNLISVGTGCPVTETTVIFKVEQGQGPWMVEGENSRWSSPEADCPLVDESDKHQKSKDNFLNSILFMFDKILTVERLHGYNMSTSLNPTRKKSYKCKSYGKSLQPTLDFHNYNRCYNGEHADECNECGKAFKKKFNFIRREKNHTRKKLFECNNCGKAYSSKAHLATHQKIHNRERPFVCSDCGKAFTHKAQLVVHQRLHTGEKPYECSQCGKSFTWNSSFNQHMKSHTLENSFECKECGKTFRYSSSLYKHSKFHTGEKPYQCIVCGKAFGNSSVLVTHQRIHTGEKPYGCIKCGKAFIKKSHLLRHQITHTGERPYECSKCGKPFSQKSNLIVHQKIHM", "length": 346, "header": "tr|A0A3Q1MM01-1|A0AAA9SJG8_BOVIN Computationally mapped isoform of Zinc finger protein 684 OS=Bos taurus OX=9913 GN=ZNF684 PE=3 SV=2 CANONICAL=A0AAA9SJG8-1" }, "locus": { "chromosome": "3", "start_pos": 105617457, "end_pos": 105615010, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076025.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076025.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072758.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072758.2" } ] } }, { "isoform_ac": "A0AAA9SJG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8/entry#A0AAA9SJG8-1", "sequence": { "sequence": "MINFKGSVTLQDVAVEFTPEEWQLLDCDQRTLYWDVMLENFRNLISVGTGCPVTETTVIFKVEQGQGPWMVEGENSRWSSPEADCPLVDESDKHQKSKDNFLNSILFMFDKILTVERLHGYNMSTSLNPTRKKSYKCKSYGKSLQPTLDFHNYNRCYNGEHADECNECGKAFKKKFNFIRREKNHTRKKLFECNNCGKAYSSKAHLATHQKIHNRERPFVCSDCGKAFTHKAQLVVHQRLHTGEKPYECSQCGKSFTWNSSFNQHMKSHTLENSFECKECGKTFRYSSSLYKHSKFHTGEKPYQCIVCGKAFGNSSVLVTHQRIHTGEKPYGCIKCGKAFIKKSHLLRHQITHTGERPYECSKCGKPFSQKSNLIVHQKIHM", "length": 382, "header": "tr|A0AAA9SJG8-1|A0AAA9SJG8_BOVIN Isoform 1 of Zinc finger protein 684 OS=Bos taurus OX=9913 GN=ZNF684 PE=3 SV=1 CANONICAL=A0AAA9SJG8-1" }, "locus": { "chromosome": "3", "start_pos": 105622254, "end_pos": 105615010, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133865.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133865.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084039.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084039.1" } ] } }, { "isoform_ac": "F1MR89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8/entry#F1MR89-1", "sequence": { "sequence": "MINFKGSVTLQDVAVEFTPEEWQLLDCDQRTLYWDVMLENFRNLISVGCPVTETTVIFKVEQGQGPWMVEGENSRWSSPEADCPLVDESDKHQKSKDNFLNSILFMFDKILTVERLHGYNMSTSLNPTRKKSYKCKSYGKSLQPTLDFHNYNRCYNGEHADECNECGKAFKKKFNFIRREKNHTRKKLFECNNCGKAYSSKAHLATHQKIHNRERPFVCSDCGKAFTHKAQLVVHQRLHTGEKPYECSQCGKSFTWNSSFNQHMKSHTLENSFECKECGKTFRYSSSLYKHSKFHTGEKPYQCIVCGKAFGNSSVLVTHQRIHTGEKPYGCIKCGKAFIKKSHLLRHQITHTGERPYECSKCGKPFSQKSNLIVHQKIHM", "length": 380, "header": "tr|F1MR89-1|A0AAA9SJG8_BOVIN Computationally mapped isoform of Zinc finger protein 684 OS=Bos taurus OX=9913 GN=ZNF684 PE=3 SV=3 CANONICAL=A0AAA9SJG8-1" }, "locus": { "chromosome": "3", "start_pos": 105622254, "end_pos": 105615010, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000691.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000691.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000691.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000691.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112441496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441496", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SCQ9-1", "protein_name": "Zinc finger protein 684", "gene_name": "ZNF684", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMLYARAAEMINIKGSMTLQDVAVDFTPEEWQLLDCDQRTLYWDVMLENFRNLISVGCPVPKTKVIFRMEQGHDPWMVEGENPRWRCPEADYPLVDESDKHQESKDNFLNSVLFTFNKILTVERPHSYKMSTSLNPTRKKSYRCTSYGKSLQPTLDLLSYNRCYTGENTYECNECGKAFKKKFHFIRHEKNHTRKKPFECSDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGEKPYECGQCGKSFTWNSSFTQHVKSHTLENSFECKECGKTFRYSSSLYKHSRFHTGEKPYRCIVCGKAFGNTSVLVTHQRIHTGEKPYGCIECGKAFIKKSHLLRHQITHTGEKPYECSKCGKAFSQKSNLIVHQKIHM", "length": 389 }, "evidence": [ { "id": "A0AAA9SJG8", "url": "https://omabrowser.org/oma/group/A0AAA9SJG8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5T5D7-1", "protein_name": "Zinc finger protein 684", "gene_name": "ZNF684", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MISFQESVTFQDVAVDFTAEEWQLLDCAERTLYWDVMLENYRNLISVGCPITKTKVILKVEQGQEPWMVEGANPHESSPESDYPLVDEPGKHRESKDNFLKSVLLTFNKILTMERIHHYNMSTSLNPMRKKSYKSFEKCLPPNLDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKNHTRKKPFECNDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGEKPYECSQCGKTFTWNSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQCIICGKAFGNTSVLVTHQRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRCGKAFSQKSNLIVHQKIHT", "length": 378 }, "evidence": [ { "id": "A0AAA9SJG8", "url": "https://omabrowser.org/oma/group/A0AAA9SJG8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 163, "end_pos": 190, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG8" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 81, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 314, "end_pos": 316 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLZ2-1", "uniprot_ac": "A0AAA9SLZ2", "uniprot_id": "A0AAA9SLZ2_BOVIN", "mass": { "chemical_mass": 19787.0, "monoisotopic_mass": 19787.0 }, "refseq": {}, "gene_names": [ { "name": "C3H1orf210", "type": "recommended", "evidence": [ { "id": "A0AAA9SLZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2" } ] } ], "protein_names": [ { "name": "Chromosome 3 C1orf210 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SLZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C3H1orf210", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2", "locus": { "chromosome": "3", "start_pos": 102744929, "end_pos": 102741183, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021079", "url": "https://www.ensembl.org/id/ENSBTAG00000021079" } ] } } ], "crossref": [ { "id": "A0AAA9SLZ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021079", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021079", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "PTHR31450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31450:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31450:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MMT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMT9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSDLVHRPITDMDERCFSAWTLLPGPLLIQIPPAPAPVPPGLCPRAAWHPGVSLEPGLFWQRLRLPVSSGPSMSEANQTIVGSSEVPTTSTVSSGPGSGIQTWLVLVGVVLGAVVLSILIAVAAKCHLCRKHRASYQHHPLPETGKGGRPEVVEDEDDDGFIEDNYIQPGFGGLETGASRDHFSL", "length": 186, "header": "tr|A0AAA9SLZ2-1|A0AAA9SLZ2_BOVIN Isoform 1 of Chromosome 3 C1orf210 homolog OS=Bos taurus OX=9913 GN=C3H1orf210 PE=4 SV=2 CANONICAL=A0AAA9SLZ2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2/entry#A0A3Q1MMT9-1", "sequence": { "sequence": "MASCPVSRVRAVPSCGCECGPERVSVAVLDPYLRVYIPGLCPRAAWHPGVSLEPGLFWQRLRLPVSSGPSMSEANQTIVGSSEVPTTSTVSSGPGSGIQTWLVLVGVVLGAVVLSILIAVAAKCHLCRKHRASYQHHPLPETGKGGRPEVVEDEDDDGFIEDNYIQPGFGGLETGASRDHFSL", "length": 183, "header": "tr|A0A3Q1MMT9-1|A0AAA9SLZ2_BOVIN Computationally mapped isoform of Chromosome 3 C1orf210 homolog OS=Bos taurus OX=9913 GN=C3H1orf210 PE=4 SV=3 CANONICAL=A0AAA9SLZ2-1" }, "locus": { "chromosome": "3", "start_pos": 102743987, "end_pos": 102743300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085697.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085697.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070778.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070778.3" } ] } }, { "isoform_ac": "A0AAA9SLZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2/entry#A0AAA9SLZ2-1", "sequence": { "sequence": "MGSDLVHRPITDMDERCFSAWTLLPGPLLIQIPPAPAPVPPGLCPRAAWHPGVSLEPGLFWQRLRLPVSSGPSMSEANQTIVGSSEVPTTSTVSSGPGSGIQTWLVLVGVVLGAVVLSILIAVAAKCHLCRKHRASYQHHPLPETGKGGRPEVVEDEDDDGFIEDNYIQPGFGGLETGASRDHFSL", "length": 186, "header": "tr|A0AAA9SLZ2-1|A0AAA9SLZ2_BOVIN Isoform 1 of Chromosome 3 C1orf210 homolog OS=Bos taurus OX=9913 GN=C3H1orf210 PE=4 SV=2 CANONICAL=A0AAA9SLZ2-1" }, "locus": { "chromosome": "3", "start_pos": 102743987, "end_pos": 102742184, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113876.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113876.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086298.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086298.2" } ] } }, { "isoform_ac": "A0AAA9TCC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ2/entry#A0AAA9TCC4-1", "sequence": { "sequence": "MMRGVLGQPHRCFSAWTLLPGPLLIQIPPAPAPVPPGLCPRAAWHPGVSLEPGLFWQRLRLPVSSGPSMSEANQTIVGSSEVPTTSTVSSGPGSGIQTWLVLVGVVLGAVVLSILIAVAAKCHLCRKHRASYQHHPLPETGKGGRPEVVEDEDDDGFIEDNYIQPGFGGLETGASRDHFSL", "length": 181, "header": "tr|A0AAA9TCC4-1|A0AAA9TCC4_BOVIN Computationally mapped isoform of Chromosome 3 C1orf210 homolog OS=Bos taurus OX=9913 GN=C3H1orf210 PE=4 SV=1 CANONICAL=A0AAA9SLZ2-1" }, "locus": { "chromosome": "3", "start_pos": 102743987, "end_pos": 102741922, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088717.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088717.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094388.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094388.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJA0-1", "uniprot_ac": "A0AAA9SJA0", "uniprot_id": "A0AAA9SJA0_BOVIN", "mass": { "chemical_mass": 31609.0, "monoisotopic_mass": 31609.0 }, "refseq": { "ac": "NP_001069008", "name": "hydroxyacylglutathione hydrolase-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069008" }, "gene_names": [ { "name": "HAGHL", "type": "recommended", "evidence": [ { "id": "A0AAA9SJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" } ] }, { "name": "HAGHL", "type": "synonym", "evidence": [ { "id": "NP_001069008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069008" } ] } ], "protein_names": [ { "name": "Hydroxyacylglutathione hydrolase like", "type": "synonym", "evidence": [ { "id": "A0AAA9SJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0/entry#names_and_taxonomy" } ] }, { "name": "hydroxyacylglutathione hydrolase-like protein", "type": "synonym", "evidence": [ { "id": "NP_001069008", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069008" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAGHL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0", "locus": { "chromosome": "25", "start_pos": 628863, "end_pos": 625490, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002481", "url": "https://www.ensembl.org/id/ENSBTAG00000002481" } ] } } ], "crossref": [ { "id": "A0AAA9SJA0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002481", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002481", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07723", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07723", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511836", "url": "https://www.ncbi.nlm.nih.gov/gene/511836", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511836", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511836", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11935:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11935:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16123", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16123", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069008", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQE9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVKVIPVLEDNYMYLVIEERTREAVAVDVAVPKRLLEIVGRERVSLTTVLTTHHHWDHARGNAELARLLPGLVVLGADERICALTRRLAHGEELRFGAIHVRCLLTPGHTLGHMSYFLWEEECPDPPAVFSGDALSVAGCGSRLEGTVQQMYQSLVETLGTLPPETKVFCGHEHTLGNLEFAQKVEPYNDHVKAKLSWAKQRDEDDVPTVPATLGEELLYNPFLRVAEESVRKFTGKVAPADVLDVLCRERASFERAAEPLQPQARALLALQWGLLSTPRQK", "length": 283, "header": "tr|A0AAA9SJA0-1|A0AAA9SJA0_BOVIN Isoform 1 of Hydroxyacylglutathione hydrolase like OS=Bos taurus OX=9913 GN=HAGHL PE=3 SV=2 CANONICAL=A0AAA9SJA0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0/entry#A0A3Q1MQE9-1", "sequence": { "sequence": "MKVKVIPVLEDNYMYLVIEERTREAVAVDVAVPKRLLEIVGRERVSLTTVLTTHHHWDHARGNAELARLLPGLVVLGADERICALTRRLAHGEELRFGAIHVRCLLTPGHTLGHMSYFLWEEECPDPPAVFSGTGCPVPTCPTSLCPIPLSLTHPTPQGMHCPWPAAAHAWRAQFSRCTRAWWRPWAPCPLRHRGMRTMCPRCRQPWAKNSFTTPS", "length": 216, "header": "tr|A0A3Q1MQE9-1|A0AAA9SJA0_BOVIN Computationally mapped isoform of Hydroxyacylglutathione hydrolase like OS=Bos taurus OX=9913 GN=HAGHL PE=3 SV=2 CANONICAL=A0AAA9SJA0-1" }, "locus": { "chromosome": "25", "start_pos": 627848, "end_pos": 626103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081621.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081621.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073831.2" } ] } }, { "isoform_ac": "A0AAA9SJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0/entry#A0AAA9SJA0-1", "sequence": { "sequence": "MKVKVIPVLEDNYMYLVIEERTREAVAVDVAVPKRLLEIVGRERVSLTTVLTTHHHWDHARGNAELARLLPGLVVLGADERICALTRRLAHGEELRFGAIHVRCLLTPGHTLGHMSYFLWEEECPDPPAVFSGDALSVAGCGSRLEGTVQQMYQSLVETLGTLPPETKVFCGHEHTLGNLEFAQKVEPYNDHVKAKLSWAKQRDEDDVPTVPATLGEELLYNPFLRVAEESVRKFTGKVAPADVLDVLCRERASFERAAEPLQPQARALLALQWGLLSTPRQK", "length": 283, "header": "tr|A0AAA9SJA0-1|A0AAA9SJA0_BOVIN Isoform 1 of Hydroxyacylglutathione hydrolase like OS=Bos taurus OX=9913 GN=HAGHL PE=3 SV=2 CANONICAL=A0AAA9SJA0-1" }, "locus": { "chromosome": "25", "start_pos": 628299, "end_pos": 626103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130170.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130170.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082660.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082660.2" } ] } }, { "isoform_ac": "A0AAA9TBY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0/entry#A0AAA9TBY9-1", "sequence": { "sequence": "MKVKVIPVLEDNYMYLVIEERTREAVAVDVAVPKRGPRSWQRGTGEAAAWSGGLGCGRAHLCADAQAGTWRGAAEGVLWSRAHTG", "length": 85, "header": "tr|A0AAA9TBY9-1|A0AAA9TBY9_BOVIN Computationally mapped isoform of Hydroxyacylglutathione hydrolase like OS=Bos taurus OX=9913 GN=HAGHL PE=4 SV=1 CANONICAL=A0AAA9SJA0-1" }, "locus": { "chromosome": "25", "start_pos": 627416, "end_pos": 626103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099180.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099180.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094217.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094217.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511836", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511836", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" } ], "pmid": "" }, { "name": "hydroxyacylglutathione hydrolase activity", "id": "GO:0004416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione", "id": "GO:0019243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019243", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA0" }, { "id": "SM00849", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Metallo-beta-lactamase", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 173, "start_aa": "Asp", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKS2-1", "uniprot_ac": "A0AAA9SKS2", "uniprot_id": "A0AAA9SKS2_BOVIN", "mass": { "chemical_mass": 132398.0, "monoisotopic_mass": 132398.0 }, "refseq": { "ac": "XP_059737598", "name": "tectonin beta-propeller repeat-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737598" }, "gene_names": [ { "name": "TECPR1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ] }, { "name": "TECPR1", "type": "synonym", "evidence": [ { "id": "XP_059737598", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737598" } ] } ], "protein_names": [ { "name": "Tectonin beta-propeller repeat-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2/entry#names_and_taxonomy" } ] }, { "name": "tectonin beta-propeller repeat-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059737598", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737598" } ] } ], "function": [ { "annotation": "Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LFS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFS7#function" }, { "database": "UniProtKB", "id": "ARBA00059274", "url": "https://www.uniprot.org/uniprotkb/ARBA00059274#function" }, { "database": "UniProtKB", "id": "A0A3Q1MSC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSC0#function" }, { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2#function" }, { "database": "UniProtKB", "id": "A0AAA9TGA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TECPR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2", "locus": { "chromosome": "25", "start_pos": 37793776, "end_pos": 37765399, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051678", "url": "https://www.ensembl.org/id/ENSBTAG00000051678" } ] } } ], "crossref": [ { "id": "A0AAA9SKS2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051678", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051678", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13300", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13300", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789454", "url": "https://www.ncbi.nlm.nih.gov/gene/789454", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006624", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006624", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFS7", "url": "https://www.orthodb.org/?gene=A0A3Q1LFS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MSC0", "url": "https://www.orthodb.org/?gene=A0A3Q1MSC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23250", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23250", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23250:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23250:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06398", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06398", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059737598", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737598", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAILYSQRNEGPVPRRPTGLCAVSVAEHRCGPAHPPRSRRGKERRNSSGEWQEEGVRGRWPPKAAPAAMPSSALWAVDLFGRVFTLSTAGQHWEPCRDAQLEFKRVSAARDCCWGIACDHQVYVLVGASDVPIRCQEEAYENQRWNPVGGFCETLLPSDRWPWSDVSGLQHRPLDGVALPSLHWEWESDWYVDENFGGEPTEKGGWTYAIDFPAAYTRDKKWNSCVRRRRWIRYRRYKSQDAWAKIPSEDDPQQLPDPFSDLSVGGWEVTDEPVGRLSVWAVTLQGKVWYRENVSHHNPEGSSWSLVDTPGEAVQISCGPHDLLWVTLWEGQALVREGINRNNPKGSSWSTVEPPTSENGILHVSTGVCVVWAVTKDRKVWFRRGVNSHNPCGTSWIEMFGEMMMVNVGLNDQVWGIGCVDRALYFRQGVTQSELSGKTWKVIVAGREGDRSLSGSSFSLHSAGCFFGNEVRGSAESCGPGDTDASWEVPGPASSPAGLRGKESWKGPSHATANFPEATDLSSLRLLPLGLEEPDSADCHALWAWVSGGGCAVEAHTTLKWFTTQSGLCPSVQTLSLSITPAQTAAWRKQIFQQLTERTKRELENFQHYEQAVEQSVWVKTGALQWWCDWKPHKWMDVHVALEQLTGHDGAQDSILFIYYVVHEEKKYIHVFLNEVTALVPVFSEAKHSFALYTPERTRQRWPVRLAAATEQDMSDWLTLLNLSCCESRRMHGRPSPQAIWSVTCKGDIFVSEPSPDLEGPERRLPCDQMFWRQIGGHLRVVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNVFTQWDVKFVHIYENQRWNPVTGYTSRGLPTDRYMWSDATGLQECTKASTKPPSLQWTWVSDWFVDFSVPGGTDPEGWQYASDFPASYHKYKTMKDFVRRRCWARKCKLVTTGPWLEVTSVALRDVSIIPESPGAHGSGLNIALWAISDKGDVLCRLGVSELNPEGFCWMHVGTDQPFTSVSIGTCYQVWAVARDGSAFYRSSVSPSRPNGDCWYHIPPPPKQRLKQVSVGHTSVFALDENGNLWYRQGVTPSHPQGDSWEHVSNNVRHVSVGPLDQVWVIADKVQGSHSLSRGTVCRRTGVQSLEPKGQGWDYGIGGGWDHLSIRASATRAPRSSSQKPASKQNGQPPSVAGGPWQTPGPVCC", "length": 1185, "header": "tr|A0AAA9SKS2-1|A0AAA9SKS2_BOVIN Isoform 1 of Tectonin beta-propeller repeat-containing protein 1 OS=Bos taurus OX=9913 GN=TECPR1 PE=3 SV=1 CANONICAL=A0AAA9SKS2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2/entry#A0A3Q1LFS7-1", "sequence": { "sequence": "MPSSALWAVDLFGRVFTLSTAGQHWEPCRDAQLEFKRVSAARDCCWGIACDHQVYVLVGASDVPIRCQEEAYENQRWNPVGGFCETLLPSDRWPWSDVSGLQHRPLDGVALPSLHWEWESDWYVDENFGGEPTEKGGWTYAIDFPAAYTRDKKWNSCVRRRRWIRYRRYKSQDAWAKIPSEDDPQQLPDPFSDLSVGGWEVTDEPVGRLSVWAVTLQGKVWYRENVSHHNPEGSSWSLVDTPGEAVQISCGPHDLLWVTLWEGQALVREGINRNNPKGSSWSTVEPPTSENGILHVSTGVCVVWAVTKDRKVWFRRGVNSHNPCGTSWIEMFGEMMMVNVGLNDQVWGIGCVDRALYFRQGVTQSELSGKTWKVIVAGREGDRSLSGSSFSLHSAGCFFGNEVRGSAESCGPGDTDASWEVPGPASSPAGLRGKESWKGPSHATANFPEATDLSSLRLLPLGLEEPDSADCHALWAWVSGGGCAVEAHTTLKWFTTQSGLCPSVQTLSLSITPAQTAAWRKQIFQQLTERTKRELENFQHYEQAVEQSVWVKTGALQWWCDWKPHKWMDVHVALEQLTGHDGAQDSILFIYYVVHEEKKYIHVFLNEVTALVPVFSEAKHSFALYTPERTRQRWPVRLAAATEQDMSDWLTLLNLSCCESRRMHGRPSPQAIWSVTCKGDIFVSEPSPDLEGPERRLPCDQMFWRQIGGHLRVVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNVFTQWDVKFVHIYENQRWNPVTGYTSRGLPTDRYMWSDATGLQECTKASTKPPSLQWTWVSDWFVDFSVPGGTDPEGWQYASDFPASYHKYKTMKDFVRRRCWARKCKLVTTGPWLEVTSVALRDVSIIPESPGAHGSGLNIALWAISDKGDVLCRLGVSELNPEGFCWMHVGTDQPFTSVSIGTCYQVWAVARDGSAFYRSSVSPSRPNGNLWYRQGVTPSHPQGDSWEHVSNNVRHVSVGPLDQVWVIADKVQGSHSLSRGTVCRRTGVQSLEPKGQGWDYGIGGGWDHLSIRASATRAPRSSSQKPASKQNGQPPSVAGGPWQTPGPVCC", "length": 1085, "header": "tr|A0A3Q1LFS7-1|A0A3Q1LFS7_BOVIN Computationally mapped isoform of Tectonin beta-propeller repeat-containing protein 1 OS=Bos taurus OX=9913 GN=TECPR1 PE=3 SV=3 CANONICAL=A0AAA9SKS2-1" }, "locus": { "chromosome": "25", "start_pos": 37792772, "end_pos": 37770280, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072906.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072906.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057089.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057089.3" } ] } }, { "isoform_ac": "A0A3Q1MSC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2/entry#A0A3Q1MSC0-1", "sequence": { "sequence": "MGAGLAAASCPRSPPPRGRAGPLSSRRGAIAATPPARCPSPAAPAAMPSSALWAVDLFGRVFTLSTAGQHWEPCRDAQLEFKRVSAARDCCWGIACDHQVYVLVGASDVPIRCQEEAYENQRWNPVGGFCETLLPSDRWPWSDVSGLQHRPLDGVALPSLHWEWESDWYVDENFGGEPTEKGGWTYAIDFPAAYTRDKKWNSCVRRRRWIRYRRYKSQDAWAKIPSEDDPQQLPDPFSDLSVGGWEVTDEPVGRLSVWAVTLQGKVWYRENVSHHNPEGSSWSLVDTPGEAVQISCGPHDLLWVTLWEGQALVREGINRNNPKGSSWSTVEPPTSENGILHVSTGVCVVWAVTKDRKVWFRRGVNSHNPCGTSWIEMFGEMMMVNVGLNDQVWGIGCVDRALYFRQGVTQSELSGKTWKVIVAGREGDRSLSGSSFSLHSAGCFFGNEVRGSAESCGPGDTDASWEVPGPASSPAGLRGKESWKGPSHATANFPEATDLSSLRLLPLGLEEPDSADCHALWAWVSGGGCAVEAHTTLKWFTTQSGLCPSVQTLSLSITPAQTAAWRKQIFQQLTERTKRELENFQHYEQAVEQVRNARGTSSSRHPSVWVKTGALQWWCDWKPHKWMDVHVALEQLTGHDGAQDSILFIYYVVHEEKKYIHVFLNEVTALVPVFSEAKHSFALYTPERTRQRWPVRLAAATEQDMSDWLTLLNLSCCESRRMHGRPSPQAIWSVTCKGDIFVSEPSPDLEGPERRLPCDQMFWRQIGGHLRVVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNVFTQWDVKFVHIYENQRWNPVTGYTSRGLPTDRYMWSDATGLQECTKASTKPPSLQWTWVSDWFVDFSVPGGTDPEGWQYASDFPASYHKYKTMKDFVRRRCWARKCKLVTTGPWLEVTSVALRDVSIIPESPGAHGSGLNIALWAISDKGDVLCRLGVSELNPEGFCWMHVGTDQPFTSVSIGTCYQVWAVARDGSAFYRSSVSPSRPNGDCWYHIPPPPKQRLKQVSVGHTSVFALDENGNLWYRQGVTPSHPQGDSWEHVSNNVRHVSVGPLDQVWVIADKVQGSHSLSRGTVCRRTGVQSLEPKGQGWDYGIGGGWDHLSIRASATRAPRSSSQKPASKQNGQPPSVAGGPWQTPGPVCC", "length": 1175, "header": "tr|A0A3Q1MSC0-1|A0AAA9SKS2_BOVIN Computationally mapped isoform of Tectonin beta-propeller repeat-containing protein 1 OS=Bos taurus OX=9913 GN=TECPR1 PE=3 SV=2 CANONICAL=A0AAA9SKS2-1" }, "locus": { "chromosome": "25", "start_pos": 37792772, "end_pos": 37765428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084275.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084275.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072893.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072893.2" } ] } }, { "isoform_ac": "A0AAA9SKS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2/entry#A0AAA9SKS2-1", "sequence": { "sequence": "MKAILYSQRNEGPVPRRPTGLCAVSVAEHRCGPAHPPRSRRGKERRNSSGEWQEEGVRGRWPPKAAPAAMPSSALWAVDLFGRVFTLSTAGQHWEPCRDAQLEFKRVSAARDCCWGIACDHQVYVLVGASDVPIRCQEEAYENQRWNPVGGFCETLLPSDRWPWSDVSGLQHRPLDGVALPSLHWEWESDWYVDENFGGEPTEKGGWTYAIDFPAAYTRDKKWNSCVRRRRWIRYRRYKSQDAWAKIPSEDDPQQLPDPFSDLSVGGWEVTDEPVGRLSVWAVTLQGKVWYRENVSHHNPEGSSWSLVDTPGEAVQISCGPHDLLWVTLWEGQALVREGINRNNPKGSSWSTVEPPTSENGILHVSTGVCVVWAVTKDRKVWFRRGVNSHNPCGTSWIEMFGEMMMVNVGLNDQVWGIGCVDRALYFRQGVTQSELSGKTWKVIVAGREGDRSLSGSSFSLHSAGCFFGNEVRGSAESCGPGDTDASWEVPGPASSPAGLRGKESWKGPSHATANFPEATDLSSLRLLPLGLEEPDSADCHALWAWVSGGGCAVEAHTTLKWFTTQSGLCPSVQTLSLSITPAQTAAWRKQIFQQLTERTKRELENFQHYEQAVEQSVWVKTGALQWWCDWKPHKWMDVHVALEQLTGHDGAQDSILFIYYVVHEEKKYIHVFLNEVTALVPVFSEAKHSFALYTPERTRQRWPVRLAAATEQDMSDWLTLLNLSCCESRRMHGRPSPQAIWSVTCKGDIFVSEPSPDLEGPERRLPCDQMFWRQIGGHLRVVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNVFTQWDVKFVHIYENQRWNPVTGYTSRGLPTDRYMWSDATGLQECTKASTKPPSLQWTWVSDWFVDFSVPGGTDPEGWQYASDFPASYHKYKTMKDFVRRRCWARKCKLVTTGPWLEVTSVALRDVSIIPESPGAHGSGLNIALWAISDKGDVLCRLGVSELNPEGFCWMHVGTDQPFTSVSIGTCYQVWAVARDGSAFYRSSVSPSRPNGDCWYHIPPPPKQRLKQVSVGHTSVFALDENGNLWYRQGVTPSHPQGDSWEHVSNNVRHVSVGPLDQVWVIADKVQGSHSLSRGTVCRRTGVQSLEPKGQGWDYGIGGGWDHLSIRASATRAPRSSSQKPASKQNGQPPSVAGGPWQTPGPVCC", "length": 1185, "header": "tr|A0AAA9SKS2-1|A0AAA9SKS2_BOVIN Isoform 1 of Tectonin beta-propeller repeat-containing protein 1 OS=Bos taurus OX=9913 GN=TECPR1 PE=3 SV=1 CANONICAL=A0AAA9SKS2-1" }, "locus": { "chromosome": "25", "start_pos": 37792772, "end_pos": 37769498, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091223.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091223.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084510.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084510.1" } ] } }, { "isoform_ac": "A0AAA9TGA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2/entry#A0AAA9TGA5-1", "sequence": { "sequence": "MCTRIFYSRGSLQTSPPAPAAMPSSALWAVDLFGRVFTLSTAGQHWEPCRDAQLEFKRVSAARDCCWGIACDHQVYVLVGASDVPIRCQEEAYENQRWNPVGGFCETLLPSDRWPWSDVSGLQHRPLDGVALPSLHWEWESDWYVDENFGGEPTEKGGWTYAIDFPAAYTRDKKWNSCVRRRRWIRYRRYKSQDAWAKIPSEDDPQQLPDPFSDLSVGGWEVTDEPVGRLSVWAVTLQGKVWYRENVSHHNPEGSSWSLVDTPGEAVQISCGPHDLLWVTLWEGQALVREGINRNNPKGSSWSTVEPPTSENGILHVSTGVCVVWAVTKDRKVWFRRGVNSHNPCGTSWIEMFGEMMMVNVGLNDQVWGIGCVDRALYFRQGVTQSELSGKTWKVIVAGREGDRSLSGSSFSLHSAGCFFGNEVRGSAESCGPGDTDASWEVPGPASSPAGLRGKESWKGPSHATANFPEATDLSSLRLLPLGLEEPDSADCHALWAWVSGGGCAVEAHTTLKWFTTQSGLCPSVQTLSLSITPAQTAAWRKQIFQQLTERTKRELENFQHYEQAVEQSVWVKTGALQWWCDWKPHKWMDVHVALEQLTGHDGAQDSILFIYYVVHEEKKYIHVFLNEVTALVPVFSEAKHSFALYTPERTRQRWPVRLAAATEQDMSDWLTLLNLSCCESRRMHGRPSPQAIWSVTCKGDIFVSEPSPDLEGPERRLPCDQMFWRQIGGHLRVVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNVFTQWDVKFVHIYENQRWNPVTGYTSRGLPTDRYMWSDATGLQECTKASTKPPSLQWTWVSDWFVDFSVPGGTDPEGWQYASDFPASYHKYKTMKDFVRRRCWARKCKLVTTGPWLEVTSVALRDVSIIPESPGAHGSGLNIALWAISDKGDVLCRLGVSELNPEGFCWMHVGTDQPFTSVSIGTCYQVWAVARDGSAFYRSSVSPSRPNGDCWYHIPPPPKQRLKQVSVGHTSVFALDENGNLWYRQGVTPSHPQGDSWEHVSNNVRHVSVGPLDQVWVIADKVQGSHSLSRGTVCRRTGVQSLEPKGQGWDYGIGGGWDHLSIRASATRAPRSSSQKPASKQNGQPPSVAGGPWQTPGPVCC", "length": 1137, "header": "tr|A0AAA9TGA5-1|A0AAA9TGA5_BOVIN Computationally mapped isoform of Tectonin beta-propeller repeat-containing protein 1 OS=Bos taurus OX=9913 GN=TECPR1 PE=3 SV=1 CANONICAL=A0AAA9SKS2-1" }, "locus": { "chromosome": "25", "start_pos": 37792772, "end_pos": 37766719, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110382.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110382.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096068.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096068.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1072, "start_aa": "Thr", "end_pos": 1072, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1072", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" }, { "name": "regulation of autophagosome maturation", "id": "GO:1901096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS2" }, { "id": "SM00693", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00693" }, { "id": "SM00694", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00694" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peroxin/Ferlin", "eco_id": "ECO_0000259", "start_pos": 133, "end_pos": 194, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1072 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 294, "end_pos": 296 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 723, "end_pos": 725 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKT8-1", "uniprot_ac": "A0AAA9SKT8", "uniprot_id": "A0AAA9SKT8_BOVIN", "mass": { "chemical_mass": 33983.0, "monoisotopic_mass": 33983.0 }, "refseq": { "ac": "NP_001231277", "name": "ciliary-associated calcium-binding coiled-coil protein 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231277" }, "gene_names": [ { "name": "CABCOCO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8" } ] }, { "name": "C10orf107", "type": "synonym", "evidence": [ { "id": "NP_001231277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231277" } ] }, { "name": "C28H10orf107", "type": "synonym", "evidence": [ { "id": "NP_001231277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231277" } ] }, { "name": "CABCOCO1", "type": "synonym", "evidence": [ { "id": "NP_001231277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231277" } ] } ], "protein_names": [ { "name": "Ciliary associated calcium binding coiled-coil 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8/entry#names_and_taxonomy" } ] }, { "name": "ciliary-associated calcium-binding coiled-coil protein 1 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001231277", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231277" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CABCOCO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8", "locus": { "chromosome": "28", "start_pos": 17758585, "end_pos": 17588040, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010967", "url": "https://www.ensembl.org/id/ENSBTAG00000010967" } ] } } ], "crossref": [ { "id": "A0AAA9SKT8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010967", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010967", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510670", "url": "https://www.ncbi.nlm.nih.gov/gene/510670", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510670", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510670", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LEDNIKW", "url": "https://omabrowser.org/oma/group/LEDNIKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTY4", "url": "https://www.orthodb.org/?gene=A0A3Q1MTY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPD1", "url": "https://www.orthodb.org/?gene=A0A3S5ZPD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28457", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28457", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28457:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28457:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14769", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14769", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001231277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231277", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTY4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPD1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATFVGTTPGGTTPAGMTSAGTTPESEKDAEFQEHEKILSPDFLSVAQITEMLAEDVDGVQQKLEKFLNFKNLQTCLKEASLLDYYVSGFLWAKGMDFSVIQYSKFMTLLDMLLHNLRTLHMSLEDSIKWLGEVMAEIGPSHKNEKWNIFDVKQASAIVDYLKISLFQHYKLYEFLFFSAREEIVIGTEQLIEVVNPADHPFPDPLEEGISFDIYSTFIEPPPPLDMEIKGLNQEQGPGESQPEADTSETDLLVGFTIEEIKSVLDQVTDDILISIQTEINEKLQIQEEAFNARIEKLKKA", "length": 301, "header": "tr|A0AAA9SKT8-1|A0AAA9SKT8_BOVIN Isoform 1 of Ciliary associated calcium binding coiled-coil 1 OS=Bos taurus OX=9913 GN=CABCOCO1 PE=4 SV=2 CANONICAL=A0AAA9SKT8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8/entry#A0A3Q1MTY4-1", "sequence": { "sequence": "MKLEKFLNFKNLQTCLKEASLLDYYVSGFLWAKGMDFSVIQYSKFMTLLDMLLHNLRTLHMSLEDSIKWLGEVMAEIGPSHKNEKWNIFDVKQASAIVDYLKISLFQHYKLYEFLFFSAREEIVIGTEQLIEVVNPADHPFPDPLEEGISFDIYSTFIEPPPPLDMEIKGLNQEQGPGESQPEADTSETDLLVGFTIEEIKSVLDQVTDDILISIQTEINEKLQIQEEAFNARIEKLKKA", "length": 240, "header": "tr|A0A3Q1MTY4-1|A0AAA9SKT8_BOVIN Computationally mapped isoform of Ciliary associated calcium binding coiled-coil 1 OS=Bos taurus OX=9913 GN=CABCOCO1 PE=4 SV=2 CANONICAL=A0AAA9SKT8-1" }, "locus": { "chromosome": "28", "start_pos": 17758305, "end_pos": 17621000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072855.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072855.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073903.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073903.2" } ] } }, { "isoform_ac": "A0A3S5ZPD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8/entry#A0A3S5ZPD1-1", "sequence": { "sequence": "MATFVGTTPGGTTPAGMTSAGTTPESEKDAEFQEHEKILSPDFLSVAQITEMLAEDVDGVQQKLEKFLNFKNLQTCLKEASLLDYYVSGFLWAKGMDFSVIQYSKFMTLLDMLLHNLRTLHMSLEDSIKWLGEVMAEIGPSHKNEKWNIFDVKQASAIVDYLKISLFQHYKLYEFLFFSAREEIVIGTEDQRFLKEKKLKKNITAVFKSEGLTGLKRRETKDYWLALLDLV", "length": 231, "header": "tr|A0A3S5ZPD1-1|A0AAA9SKT8_BOVIN Computationally mapped isoform of Ciliary associated calcium binding coiled-coil 1 OS=Bos taurus OX=9913 GN=CABCOCO1 PE=4 SV=1 CANONICAL=A0AAA9SKT8-1" }, "locus": { "chromosome": "28", "start_pos": 17676476, "end_pos": 17588177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014562.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014562.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014562.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014562.6" } ] } }, { "isoform_ac": "A0AAA9SKT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT8/entry#A0AAA9SKT8-1", "sequence": { "sequence": "MATFVGTTPGGTTPAGMTSAGTTPESEKDAEFQEHEKILSPDFLSVAQITEMLAEDVDGVQQKLEKFLNFKNLQTCLKEASLLDYYVSGFLWAKGMDFSVIQYSKFMTLLDMLLHNLRTLHMSLEDSIKWLGEVMAEIGPSHKNEKWNIFDVKQASAIVDYLKISLFQHYKLYEFLFFSAREEIVIGTEQLIEVVNPADHPFPDPLEEGISFDIYSTFIEPPPPLDMEIKGLNQEQGPGESQPEADTSETDLLVGFTIEEIKSVLDQVTDDILISIQTEINEKLQIQEEAFNARIEKLKKA", "length": 301, "header": "tr|A0AAA9SKT8-1|A0AAA9SKT8_BOVIN Isoform 1 of Ciliary associated calcium binding coiled-coil 1 OS=Bos taurus OX=9913 GN=CABCOCO1 PE=4 SV=2 CANONICAL=A0AAA9SKT8-1" }, "locus": { "chromosome": "28", "start_pos": 17758305, "end_pos": 17588177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125191.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125191.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086971.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086971.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510670", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510670", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B5F7-1", "protein_name": "Ciliary associated calcium binding coiled-coil 1", "gene_name": "CABCOCO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATSVGTTPGGTTPAGMIPAGTTPESENGAEFQEHERILSPDFLSVAQITEMLAEDADGVQRKLEKFLNFKNLHTCLKEAILLDYYVSGFLWARGMDFSIIQYSKFMTLLDMLLHNLRTLRMSLEDSIKWLGEVMAEIGPSHSQKNEEWNIFDIKQTNAIVDYLKVSLFQHYKLYEFLFYSTREEIVIGTEQVIEVVKPVGHPFPDPLEEGMAFDIYSTFIEPPPTLDMEMKELHQEQGPEESHPEANTSETDPLVGFTIEDIKSVLSQVTDDILIGIQTEINEKLQIQEEAFNARIEKLKKA", "length": 303 }, "evidence": [ { "id": "A0AAA9SKT8", "url": "https://omabrowser.org/oma/group/A0AAA9SKT8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZD36-1", "protein_name": "Ciliary associated calcium binding coiled-coil 1", "gene_name": "Cabcoco1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRASSRENVAGSSIGLTSWGPTTPGVTPAGSTTDSEENERILSPDILTTNQIIDLLGEEDVEKIQEKMGTFLNFKNLQTSLRDAILLDYYVAGFCWAKGMNFSIDQYSKFMTLLDMLLQNLQTLHMSLEDSIKWLGEVMAEIGPNHSQKNKNFHIFNVKEANAIIDYLKISLFQHYRLYEFLFYSAREEIVIGTEQTIEAVKPADHPFPAPLEEGISLSMYSAFIEPLPTLDTEQKGLDQEQGPQESLLESEMGEEDPLGGFTIDDVKLALARVTDEVLISIQNEINEKLQVQEESFNARIEKLKKA", "length": 307 }, "evidence": [ { "id": "A0AAA9SKT8", "url": "https://omabrowser.org/oma/group/A0AAA9SKT8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CDT7-1", "protein_name": "Ciliary-associated calcium-binding coiled-coil protein 1", "gene_name": "Cabcoco1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFSIEQYSKFMTLLDMLLHNLQTLHMSLEDSIKWLGEVMAEIGPNHSQKSEDFHVFEVKEANAIIDYLKISLFQHYRLYEFLFYSTREEIVIGTEQTIEVVKPADYPFPAPLEEGISLDTYSTFIEPLPTPDMEQKVLDQEQGTQEALLESEMREEDPLGGFTIDDVKSALERVTDEVLISMQKEISEKLQVQEEAFNARIEKLKKA", "length": 208 }, "evidence": [ { "id": "A0AAA9SKT8", "url": "https://omabrowser.org/oma/group/A0AAA9SKT8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IVU9-1", "protein_name": "Ciliary-associated calcium-binding coiled-coil protein 1", "gene_name": "CABCOCO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDFSIIQYSKFMTLLAMSLQNLKTLHMSLEESIKWLGEVMAEIGPTHSQKSEDWNIFDVKQANAIIDYLKISLFQHYKLYEFMFYSAREEIVIGTEQVIEVVKSACGPFPNPLEEGISFDIYSTFIEPPTILDTEMKRLDQEQGPEESQPETDTSDMDPLVGFTIEDVKSVLDQVTDDILIGIQTEINEKLQIQEEAFNARIEKLKKA", "length": 208 }, "evidence": [ { "id": "A0AAA9SKT8", "url": "https://omabrowser.org/oma/group/A0AAA9SKT8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLE5-1", "uniprot_ac": "A0AAA9SLE5", "uniprot_id": "A0AAA9SLE5_BOVIN", "mass": { "chemical_mass": 101664.0, "monoisotopic_mass": 101664.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100336984", "type": "recommended", "evidence": [ { "id": "A0AAA9SLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ] } ], "protein_names": [ { "name": "Zinc finger protein 420-like", "type": "recommended", "evidence": [ { "id": "A0AAA9SLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100336984", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLE5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037710", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037710", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NFT1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFT1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRCVCYITSPEKTQQEEEEEEMAASQGRLTFQDVAIDFTQEEWECLDLGQRELYRDVMLENYGNLASLGLVISKPDLVTFLEQMKDPWDTRRMETPAVHPAVSSHDTQGLRTQKPGLEDLFPTAKLGIYERFHLGNLHLTKDWEYMRAYKEQRACYDGQNQIGTDSHNVNITAKRNQGCESNREKPISDDQFRSSTSADKCIFVSKDPHQLLKHTRSLKGKVENLESHLVSTANTHSNNSEHRCLLNIHSNISGNQKLENEGGNSQYNHFEGSFNKGLLFFNQQLFSPCSKICNVDNNGRDLIQPSLFNTYGGIISVEQLYKRNNMSNALSRSSTPNNYKSIHDGMRSSSCSETGHNVDQDSYLMKQQGHQFSDNSKHNKYKNIFYQSSNLTINTYKSIDIGEKTYNCYDYAKAFNQSSKVIQQQNIQTKQKHYKCNICGKVFSNSPNLSRHRKIHTGRKCFKCTACGKAFNQSSYLTEHQRIHAGEKPYKCTECGKTFIYCSRVTQHQRIHTGERPYKCTACGKAFKHSSTLTEHQRIHTGERLYKCTECGKAFTRYSLLTEHQRIHTGERPYKCTECGKAFNWHLSLTVHQRTHTGEKPHKCKECGKAFISCSNLTRHQRIHTGERPYKCTDCGKAFTRYSSLTQHQRIHTGERPYKCTECGKAFNWHLSLTVHQRTHTGEKPYKCKECGKAFICCSHLTQHQRIHTGERPYKCTECGKAFTCYSLLTQHQRIHTGERPYKCTECGKAFTRYSLLTQHQRIHTGQRPYKCTDCGKAFTRYSLLTQHQRIHTGEKPYKCKDCGKAFIHCSHLTRHQRIHTGERLYKCTDCGKAFSRSSGLSQHQRIHTAGKSQKCKECGKGFHHSHHLTHHQRIHTAEKP", "length": 882, "header": "tr|A0AAA9SLE5-1|A0AAA9SLE5_BOVIN Isoform 1 of Zinc finger protein 420-like OS=Bos taurus OX=9913 GN=LOC100336984 PE=3 SV=1 CANONICAL=A0AAA9SLE5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NFT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5/entry#A0A3Q1NFT1-1", "sequence": { "sequence": "MQRCVCYITSPEKTEQEEEEEEMAASQGRLTFQDVAIDFTQEEWECLDLGQRELYRDVMLENYGNLASLGLVISKPDLVTFLEQMKDPWDTRRMETPAVHPAVSSHDTQGLRTQKPGLEDLFPTAKLGIYERFHLGNLHLTKDWEYMRAYKEQRACYDGQNQIGTDSHNVNITAKRNQGCESNREKPISDDQFRSSTSADKCIFVSKDPHQLLKHTRSLKGKVENLESHLVSTANTHSNNSEHRCLLNIHSNISGNQKLENEGGNSQYNHFEGSFNKGLLFFNQQLFSPCSKICNVDNNGRDLIQPSLFNTYGGIISVEQLYKRNNMSNALSRSSTPNNYKSIHDGMRSSSCSETGHNVDQDSYLMKQQGHQFSDNSKHNKYKNIFYQSSNLTINTYKSIDIGEKTYNCYDYAKAFNQSSKVIQQQNIQTKQKHYKCNICGKVFSNSPNLSRHRKIHTGRKCFKCTACGKAFNQSSYLTEHQRIHAGEKPYKCTECGKTFIYCSRVTQHQRIHTGERPYKCTACGKAFKHSSTLTEHQRIHTGERPYKCTECGKAFTCYSLLTQHQRIHTGERPYKCTECGKAFTRYSLLTQHQRIHTGQRPYKCTDCGKAFTRYSLLTQHQRIHTGEKPYKCKDCGKAFIHCSHLTRHQRIHTGERLYKCTDCGKAFSRSSGLSQHQRIHTAGKSQKCKECGKGFHHSHHLTHHQRIHTAEKP", "length": 714, "header": "tr|A0A3Q1NFT1-1|A0AAA9SLE5_BOVIN Computationally mapped isoform of Zinc finger protein 420-like OS=Bos taurus OX=9913 GN=LOC100336984 PE=3 SV=1 CANONICAL=A0AAA9SLE5-1" }, "locus": { "chromosome": "18", "start_pos": 57343361, "end_pos": 57220169, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076428.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076428.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070559.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070559.1" } ] } }, { "isoform_ac": "A0AAA9SLE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5/entry#A0AAA9SLE5-1", "sequence": { "sequence": "MQRCVCYITSPEKTQQEEEEEEMAASQGRLTFQDVAIDFTQEEWECLDLGQRELYRDVMLENYGNLASLGLVISKPDLVTFLEQMKDPWDTRRMETPAVHPAVSSHDTQGLRTQKPGLEDLFPTAKLGIYERFHLGNLHLTKDWEYMRAYKEQRACYDGQNQIGTDSHNVNITAKRNQGCESNREKPISDDQFRSSTSADKCIFVSKDPHQLLKHTRSLKGKVENLESHLVSTANTHSNNSEHRCLLNIHSNISGNQKLENEGGNSQYNHFEGSFNKGLLFFNQQLFSPCSKICNVDNNGRDLIQPSLFNTYGGIISVEQLYKRNNMSNALSRSSTPNNYKSIHDGMRSSSCSETGHNVDQDSYLMKQQGHQFSDNSKHNKYKNIFYQSSNLTINTYKSIDIGEKTYNCYDYAKAFNQSSKVIQQQNIQTKQKHYKCNICGKVFSNSPNLSRHRKIHTGRKCFKCTACGKAFNQSSYLTEHQRIHAGEKPYKCTECGKTFIYCSRVTQHQRIHTGERPYKCTACGKAFKHSSTLTEHQRIHTGERLYKCTECGKAFTRYSLLTEHQRIHTGERPYKCTECGKAFNWHLSLTVHQRTHTGEKPHKCKECGKAFISCSNLTRHQRIHTGERPYKCTDCGKAFTRYSSLTQHQRIHTGERPYKCTECGKAFNWHLSLTVHQRTHTGEKPYKCKECGKAFICCSHLTQHQRIHTGERPYKCTECGKAFTCYSLLTQHQRIHTGERPYKCTECGKAFTRYSLLTQHQRIHTGQRPYKCTDCGKAFTRYSLLTQHQRIHTGEKPYKCKDCGKAFIHCSHLTRHQRIHTGERLYKCTDCGKAFSRSSGLSQHQRIHTAGKSQKCKECGKGFHHSHHLTHHQRIHTAEKP", "length": 882, "header": "tr|A0AAA9SLE5-1|A0AAA9SLE5_BOVIN Isoform 1 of Zinc finger protein 420-like OS=Bos taurus OX=9913 GN=LOC100336984 PE=3 SV=1 CANONICAL=A0AAA9SLE5-1" }, "locus": { "chromosome": "18", "start_pos": 57230971, "end_pos": 57220169, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083469.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083469.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" }, { "start_pos": 617, "end_pos": 619, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 435, "end_pos": 462, "start_aa": "Tyr", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE5" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 101, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 239, "end_pos": 241 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 473, "end_pos": 475 }, { "start_pos": 617, "end_pos": 619 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJN1-1", "uniprot_ac": "A0AAA9SJN1", "uniprot_id": "A0AAA9SJN1_BOVIN", "mass": { "chemical_mass": 108079.0, "monoisotopic_mass": 108079.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM63A", "type": "recommended", "evidence": [ { "id": "A0AAA9SJN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ] } ], "protein_names": [ { "name": "Transmembrane protein 63A", "type": "synonym", "evidence": [ { "id": "A0AAA9SJN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM63A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1", "locus": { "chromosome": "16", "start_pos": 28871494, "end_pos": 28905120, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002854", "url": "https://www.ensembl.org/id/ENSBTAG00000002854" } ] } } ], "crossref": [ { "id": "A0AAA9SJN1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002854", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002854", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXL9", "url": "https://www.orthodb.org/?gene=A0A3Q1LXL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13018:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13018:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13967", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13967", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14703", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14703", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXL9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXL9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NHA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NHA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9I4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9I4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9I4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLS0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGIFFPPLHCSGLPCWFCCFFFFPDSSLWGTWRSLPSYPWACVRSWTPSSQSLQLPVLLWEESQCPGLTRALSPRTRGERLEFQGSLQRLVPYDLHQKSPAGNEQWTRGSLGGSQGHRCLCQRQLRPSPGDTSTFPSPVSGRISVMTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQCLAQSPEDRVAAADQGD", "length": 948, "header": "tr|A0AAA9SJN1-1|A0AAA9SJN1_BOVIN Isoform 1 of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=1 CANONICAL=A0AAA9SJN1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#A0A3Q1LXL9-1", "sequence": { "sequence": "MGIFFPPLHCSGLPCWFCCFFFFPDSSLWGTWRSLPSYPWACVRSWTPSSQSLQLPVLLWEESQCPGLTRALSPRTRGERLEFQGSLQRLVPYDLHQKSPAGNEQWTRGSLGGSQGHRCLCQRQLRPSPGDTSTFPSPVSGRISVMTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTGPPPVVGLGKENGAPGSQSCDHRPGRSGWD", "length": 924, "header": "tr|A0A3Q1LXL9-1|A0A3Q1LXL9_BOVIN Computationally mapped isoform of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=2 CANONICAL=A0AAA9SJN1-1" }, "locus": { "chromosome": "16", "start_pos": 28904679, "end_pos": 28873070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087455.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087455.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065528.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065528.2" } ] } }, { "isoform_ac": "A0A3Q1NHA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#A0A3Q1NHA0-1", "sequence": { "sequence": "MQAAGLGGTVMVPQSCRLVTGGDRPQLSRKGSLQRLVPYDLHQKSPAGNEQWTRGSLGGSQGHRCLCQRQLRPSPGDTSTFPSPVSGRISVMTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQCLAQSPEDRVAAADQGD", "length": 894, "header": "tr|A0A3Q1NHA0-1|A0AAA9SJN1_BOVIN Computationally mapped isoform of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=1 CANONICAL=A0AAA9SJN1-1" }, "locus": { "chromosome": "16", "start_pos": 28905088, "end_pos": 28872276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076284.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076284.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071313.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071313.2" } ] } }, { "isoform_ac": "A0AAA9S9I4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#A0AAA9S9I4-1", "sequence": { "sequence": "MRGQSPGSAPGMHRRISVMTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQCLAQSPEDRVAAADQGD", "length": 821, "header": "tr|A0AAA9S9I4-1|A0AAA9SJN1_BOVIN Computationally mapped isoform of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=1 CANONICAL=A0AAA9SJN1-1" }, "locus": { "chromosome": "16", "start_pos": 28903255, "end_pos": 28872276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123925.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123925.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080070.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080070.1" } ] } }, { "isoform_ac": "A0AAA9SJN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#A0AAA9SJN1-1", "sequence": { "sequence": "MGIFFPPLHCSGLPCWFCCFFFFPDSSLWGTWRSLPSYPWACVRSWTPSSQSLQLPVLLWEESQCPGLTRALSPRTRGERLEFQGSLQRLVPYDLHQKSPAGNEQWTRGSLGGSQGHRCLCQRQLRPSPGDTSTFPSPVSGRISVMTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQCLAQSPEDRVAAADQGD", "length": 948, "header": "tr|A0AAA9SJN1-1|A0AAA9SJN1_BOVIN Isoform 1 of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=1 CANONICAL=A0AAA9SJN1-1" }, "locus": { "chromosome": "16", "start_pos": 28904679, "end_pos": 28872276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116464.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116464.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085541.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085541.1" } ] } }, { "isoform_ac": "A0AAA9SLN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#A0AAA9SLN4-1", "sequence": { "sequence": "MPPDLLPPPCLLHLLSYVHEIVPKEPSQRPELAVTGSPTHTQTVLPHSPNICLFSIPFLVSQIFVPLTGRISVMTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQCLAQSPEDRVAAADQGD", "length": 876, "header": "tr|A0AAA9SLN4-1|A0AAA9SLN4_BOVIN Computationally mapped isoform of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=1 CANONICAL=A0AAA9SJN1-1" }, "locus": { "chromosome": "16", "start_pos": 28903752, "end_pos": 28872276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131574.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131574.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084861.1" } ] } }, { "isoform_ac": "A0AAF6DLS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1/entry#A0AAF6DLS0-1", "sequence": { "sequence": "MTESPFLELWQSRAVAIPERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVTCFLFLIAAFSIIRRKFWDYGRIALVSEGNSLHSGFAEARGLGSGASCFSCESRFRRLSSSSSGQQDFESEMGLCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTVFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPRHAKKETVESHFRDAYPTCEVVEVQLCYDVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDGLMERITEEECRVQDQPLGMAFVTFQEKSMATYVLKDFNACKCQGLQCKGEPQPSSHGRELRISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVVLFFLTTPSIILSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTKSGENWIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRKNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFKHLSPLNYKTEESASDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQCLAQSPEDRVAAADQGD", "length": 823, "header": "tr|A0AAF6DLS0-1|A0AAF6DLS0_BOVIN Computationally mapped isoform of Transmembrane protein 63A OS=Bos taurus OX=9913 GN=TMEM63A PE=3 SV=1 CANONICAL=A0AAA9SJN1-1" }, "locus": { "chromosome": "16", "start_pos": 28902159, "end_pos": 28872276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003701.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003701.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003701.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003701.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "calcium-activated cation channel activity", "id": "GO:0005227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "mechanosensitive monoatomic ion channel activity", "id": "GO:0008381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008381", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "osmolarity-sensing monoatomic cation channel activity", "id": "GO:1990760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" }, { "name": "surfactant secretion", "id": "GO:0160069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 594, "end_pos": 596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" }, { "start_pos": 923, "end_pos": 925, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" }, { "id": "PF02714", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02714" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CSC1/OSCA1-like 7TM region", "eco_id": "ECO_0000259", "start_pos": 566, "end_pos": 836, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" }, { "id": "PF13967", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13967" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CSC1/OSCA1-like N-terminal transmembrane", "eco_id": "ECO_0000259", "start_pos": 198, "end_pos": 355, "start_aa": "Val", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN1" }, { "id": "PF14703", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14703" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CSC1/OSCA1-like cytosolic", "eco_id": "ECO_0000259", "start_pos": 372, "end_pos": 554, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 309, "end_pos": 311 }, { "start_pos": 554, "end_pos": 556 }, { "start_pos": 594, "end_pos": 596 }, { "start_pos": 902, "end_pos": 904 }, { "start_pos": 923, "end_pos": 925 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM51-1", "uniprot_ac": "A0AAA9SM51", "uniprot_id": "A0AAA9SM51_BOVIN", "mass": { "chemical_mass": 52520.0, "monoisotopic_mass": 52520.0 }, "refseq": { "ac": "XP_010808879", "name": "arrestin domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808879" }, "gene_names": [ { "name": "ARRDC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SM51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ] }, { "name": "ARRDC1", "type": "synonym", "evidence": [ { "id": "XP_010808879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808879" } ] } ], "protein_names": [ { "name": "Arrestin domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SM51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51/entry#names_and_taxonomy" } ] }, { "name": "arrestin domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010808879", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808879" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARRDC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51", "locus": { "chromosome": "11", "start_pos": 106575151, "end_pos": 106565868, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012147", "url": "https://www.ensembl.org/id/ENSBTAG00000012147" } ] } } ], "crossref": [ { "id": "A0AAA9SM51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM51", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012147", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012147", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786098", "url": "https://www.ncbi.nlm.nih.gov/gene/786098", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJY5", "url": "https://www.orthodb.org/?gene=A0A3Q1MJY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPU9", "url": "https://www.orthodb.org/?gene=A0A3S5ZPU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11188:SF176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11188:SF176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010808879", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808879", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPU9", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPU9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3T7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3T7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3T7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGRQQQPAPGSGDSLGSHPGPEVFPTSQGPTHKSSSPRNTGRWASSFLWCYRFGNRTEESGSPARAAVRGCGGGWATPGLWELAEAGTQKLSWSDCRSCLGGGLLAAIRVTCTGSCRVSNKANDSAWVVEESYFNSALSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRATIDTPRFSKDHQCSRVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKARRWIYDVRTIAEVEGAGVKAWRRAQWQEQVLVPALPQSALPGCSLIHVDYYLQVSLKQPEAVVTLPVFIGNIAVNHVPLSPRPGPGLVVPSAPPQEEAEAVASGPHFFSDPVSLSTKSHSQQQQLHAALGSVPHGAPEPRPQDGSPAPHPLPPPLCISTGATVPYFAEGSGGPVPTSSTLILPPEYSSWGYPYEAPPSYEQSCGGVDPGLTPGS", "length": 494, "header": "tr|A0AAA9SM51-1|A0AAA9SM51_BOVIN Isoform 1 of Arrestin domain containing 1 OS=Bos taurus OX=9913 GN=ARRDC1 PE=3 SV=1 CANONICAL=A0AAA9SM51-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51/entry#A0A3Q1MJY5-1", "sequence": { "sequence": "SPGLCWSVGALLVFGLPVGTVPAIRVTCTGSCRVSNKANDSAWVVEESYFNSALSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRATIDTPRFSKDHQCSRVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKARRWIYDVRTIAEVEGAGVKAWRRAQWQEQVLVPALPQSALPGCSLIHVDYYLQVSLKQPEAVVTLPVFIGNIAVNHVPLSPRPGPGLVVPSAPPQEEAEAVASGPHFFSDPVSLSTKSHSQQQQLHAALGSVPHGAPEPRPQDGSPAPHPLPPPLCISTGATVPYFAEGSGGPVPTSSTLILPPEYSSWGYPYEAPPSYEQSCGGVDPGLTPGS", "length": 409, "header": "tr|A0A3Q1MJY5-1|A0A3Q1MJY5_BOVIN Computationally mapped isoform of Arrestin domain containing 1 OS=Bos taurus OX=9913 GN=ARRDC1 PE=3 SV=2 CANONICAL=A0AAA9SM51-1" }, "locus": { "chromosome": "11", "start_pos": 106574908, "end_pos": 106571669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081566.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081566.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071709.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071709.2" } ] } }, { "isoform_ac": "A0A3S5ZPU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51/entry#A0A3S5ZPU9-1", "sequence": { "sequence": "AYADSEVRIPAPVVPERERQGASQALKSPKTIRVTCTGSCRVSNKANDSAWVVEESYFNSALSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRATIDTPRFSKDHQCSRVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKARRWIYDVRTIAEVEGAGVKAWRRAQWQEQVLVPALPQSALPGCSLIHVDYYLQVSLKQPEAVVTLPVFIGNIAVNHVPLSPRPGPGLVVPSAPPQEEAEAVASGPHFFSDPVSLSTKSHSQQQQLHAALGSVPHGAPEPRPQDGSPAPHPLPPPLCISTGATVPYFAEGSGGPVPTSSTLILPPEYSSWGYPYEAPPSYEQSCGGVDPGLTPGS", "length": 417, "header": "tr|A0A3S5ZPU9-1|A0AAA9SM51_BOVIN Computationally mapped isoform of Arrestin domain containing 1 OS=Bos taurus OX=9913 GN=ARRDC1 PE=3 SV=2 CANONICAL=A0AAA9SM51-1" }, "locus": { "chromosome": "11", "start_pos": 106574908, "end_pos": 106565868, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032616.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032616.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032546.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032546.5" } ] } }, { "isoform_ac": "A0AAA9S3T7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51/entry#A0AAA9S3T7-1", "sequence": { "sequence": "MPVRQQEGGGEAIRVTCTGSCRVSNKANDSAWVVEESYFNSALSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRATIDTPRFSKDHQCSRVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKARRWIYDVRTIAEVEGAGVKAWRRAQWQEQVLVPALPQSALPGCSLIHVDYYLQVSLKQPEAVVTLPVFIGNIAVNHVPLSPRPGPGLVVPSAPPQEEAEAVASGPHFFSDPVSLSTKSHSQQQQLHAALGSVPHGAPEPRPQDGSPAPHPLPPPLCISTGATVPYFAEGSGGPVPTSSTLILPPEYSSWGYPYEAPPSYEQSCGGVDPGLTPGS", "length": 398, "header": "tr|A0AAA9S3T7-1|A0AAA9SM51_BOVIN Computationally mapped isoform of Arrestin domain containing 1 OS=Bos taurus OX=9913 GN=ARRDC1 PE=3 SV=1 CANONICAL=A0AAA9SM51-1" }, "locus": { "chromosome": "11", "start_pos": 106574908, "end_pos": 106572566, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104038.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104038.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080600.1" } ] } }, { "isoform_ac": "A0AAA9SM51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51/entry#A0AAA9SM51-1", "sequence": { "sequence": "MPGRQQQPAPGSGDSLGSHPGPEVFPTSQGPTHKSSSPRNTGRWASSFLWCYRFGNRTEESGSPARAAVRGCGGGWATPGLWELAEAGTQKLSWSDCRSCLGGGLLAAIRVTCTGSCRVSNKANDSAWVVEESYFNSALSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRATIDTPRFSKDHQCSRVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKARRWIYDVRTIAEVEGAGVKAWRRAQWQEQVLVPALPQSALPGCSLIHVDYYLQVSLKQPEAVVTLPVFIGNIAVNHVPLSPRPGPGLVVPSAPPQEEAEAVASGPHFFSDPVSLSTKSHSQQQQLHAALGSVPHGAPEPRPQDGSPAPHPLPPPLCISTGATVPYFAEGSGGPVPTSSTLILPPEYSSWGYPYEAPPSYEQSCGGVDPGLTPGS", "length": 494, "header": "tr|A0AAA9SM51-1|A0AAA9SM51_BOVIN Isoform 1 of Arrestin domain containing 1 OS=Bos taurus OX=9913 GN=ARRDC1 PE=3 SV=1 CANONICAL=A0AAA9SM51-1" }, "locus": { "chromosome": "11", "start_pos": 106574908, "end_pos": 106570299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110426.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110426.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084967.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084967.1" } ] } }, { "isoform_ac": "A0AAA9SNF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51/entry#A0AAA9SNF5-1", "sequence": { "sequence": "PLGPSCSGLRDGWSPVPQHPGSVGAPRDVGEAACVLWRAAGRALAFPEPTIRVTCTGSCRVSNKANDSAWVVEESYFNSALSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRATIDTPRFSKDHQCSRVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKARRWIYDVRTIAEVEGAGVKAWRRAQWQEQVLVPALPQSALPGCSLIHVDYYLQVSLKQPEAVVTLPVFIGNIAVNHVPLSPRPGPGLVVPSAPPQEEAEAVASGPHFFSDPVSLSTKSHSQQQQLHAALGSVPHGAPEPRPQDGSPAPHPLPPPLCISTGATVPYFAEGSGGPVPTSSTLILPPEYSSWGYPYEAPPSYEQSCGGVDPGLTPGS", "length": 436, "header": "tr|A0AAA9SNF5-1|A0AAA9SNF5_BOVIN Computationally mapped isoform of Arrestin domain containing 1 OS=Bos taurus OX=9913 GN=ARRDC1 PE=3 SV=1 CANONICAL=A0AAA9SM51-1" }, "locus": { "chromosome": "11", "start_pos": 106574908, "end_pos": 106572723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114807.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114807.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084382.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084382.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 78, "start_aa": "Thr", "end_pos": 78, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr78", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "extracellular vesicle", "id": "GO:1903561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903561", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "extracellular transport", "id": "GO:0006858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006858", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "extracellular vesicle biogenesis", "id": "GO:0140112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140112", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "arrestin family protein binding", "id": "GO:1990763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990763", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SM51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM51" }, { "id": "SM01017", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01017" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arrestin C-terminal-like", "eco_id": "ECO_0000259", "start_pos": 230, "end_pos": 354, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 78 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLC5-1", "uniprot_ac": "A0AAA9SLC5", "uniprot_id": "A0AAA9SLC5_BOVIN", "mass": { "chemical_mass": 35521.0, "monoisotopic_mass": 35521.0 }, "refseq": {}, "gene_names": [ { "name": "CDIN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5" } ] } ], "protein_names": [ { "name": "CDAN1-interacting nuclease 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDIN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5", "locus": { "chromosome": "10", "start_pos": 32520217, "end_pos": 32244014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002179", "url": "https://www.ensembl.org/id/ENSBTAG00000002179" } ] } } ], "crossref": [ { "id": "A0AAA9SLC5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLC5", "database": "AlphaFoldDB", "categories": [] }, { "id": "538758", "url": "https://www.ncbi.nlm.nih.gov/gene/538758", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31661:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31661:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RST9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RST9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0I3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S715", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S715", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S715-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S715-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ90", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AE26", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AE26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNSSRLEGPGTQRSPSSLFCLHSSWVFPGDLTRDSGFLFHLVLLSLTFIPSPKTFPRVHICLSSQLSAQYHLLDT", "length": 311, "header": "tr|A0AAA9SLC5-1|A0AAA9SLC5_BOVIN Isoform 1 of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RST9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9RST9-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRGSQIIQEGNALHRSHWFTTCLQRGQEKQFNVEHRGIYLCCCQDSCPL", "length": 286, "header": "tr|A0AAA9RST9-1|A0AAA9SLC5_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32407508, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110349.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110349.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075765.1" } ] } }, { "isoform_ac": "A0AAA9S0I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9S0I3-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRKSTGCLGRQESQEMACYILPQLNFGIIRRITSYLITRRMTL", "length": 280, "header": "tr|A0AAA9S0I3-1|A0AAA9SLC5_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32520207, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109631.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109631.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075567.1" } ] } }, { "isoform_ac": "A0AAA9S715-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9S715-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNSLHRCDRNQFIRVHMFEDYL", "length": 258, "header": "tr|A0AAA9S715-1|A0AAA9SLC5_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32388932, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127750.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127750.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080988.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080988.1" } ] } }, { "isoform_ac": "A0AAA9SLC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9SLC5-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNSSRLEGPGTQRSPSSLFCLHSSWVFPGDLTRDSGFLFHLVLLSLTFIPSPKTFPRVHICLSSQLSAQYHLLDT", "length": 311, "header": "tr|A0AAA9SLC5-1|A0AAA9SLC5_BOVIN Isoform 1 of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32372424, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123862.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123862.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083447.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083447.1" } ] } }, { "isoform_ac": "A0AAA9SSM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9SSM5-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRGSQIIQEGNALHRSHWFTTCLQRGQEKQFNVEHRGIYL", "length": 277, "header": "tr|A0AAA9SSM5-1|A0AAA9SSM5_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32373945, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134140.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134140.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086029.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086029.1" } ] } }, { "isoform_ac": "A0AAA9T1L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9T1L4-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNSFFFSTLRETPGLHRGSSSQHCSMETFSREQVGKSKCLPLSLPFIQG", "length": 285, "header": "tr|A0AAA9T1L4-1|A0AAA9T1L4_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32384589, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107182.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107182.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092675.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092675.1" } ] } }, { "isoform_ac": "A0AAA9TDN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9TDN7-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRITTNQKFSQEKMSARSSTLPSCQNSDT", "length": 266, "header": "tr|A0AAA9TDN7-1|A0AAA9TDN7_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32378654, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098343.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098343.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096242.1" } ] } }, { "isoform_ac": "A0AAA9TS33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAA9TS33-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNSIAKKAERRRIDAFEL", "length": 254, "header": "tr|A0AAA9TS33-1|A0AAA9TS33_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32415894, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112853.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112853.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101405.1" } ] } }, { "isoform_ac": "A0AAF6YJ90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAF6YJ90-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPLHLFSSAASKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVAVEGHIIHWIESKASFGDECSHHAYLHDQFWSYWNRFGPGLVIYWYGFIQELDCNRERGILLHACFPTDIVTLCHSVA", "length": 288, "header": "tr|A0AAF6YJ90-1|A0AAF6YJ90_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32472966, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002823.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002823.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002823.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002823.6" } ] } }, { "isoform_ac": "A0AAF7AE26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5/entry#A0AAF7AE26-1", "sequence": { "sequence": "MILTKAQYDEIAQCLVSVPPTRQSLRKLKQRFPSQSQATLLSIFSQEYQKHIKRTHAKHHTSEAIESYYQRYLNGVRKNGAAPVLLELANEVDYAPSLMARIILERFLQKHEEAPPSKSVINSMLRDPSQIPDGVLANQVYQCIVNDCCYGPLVDCIKHAIGHEHEVLLRDLLLEKNLSFLDEDQLRARGYDKTPDFILQVPVGLGQA", "length": 208, "header": "tr|A0AAF7AE26-1|A0AAF7AE26_BOVIN Computationally mapped isoform of CDAN1-interacting nuclease 1 OS=Bos taurus OX=9913 GN=CDIN1 PE=4 SV=1 CANONICAL=A0AAA9SLC5-1" }, "locus": { "chromosome": "10", "start_pos": 32472853, "end_pos": 32244240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072019.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072019.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067675.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067675.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 238, "end_pos": 240 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK59-1", "uniprot_ac": "A0AAA9SK59", "uniprot_id": "A0AAA9SK59_BOVIN", "mass": { "chemical_mass": 81695.0, "monoisotopic_mass": 81695.0 }, "refseq": { "ac": "XP_024851053", "name": "PWWP domain-containing protein 2A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851053" }, "gene_names": [ { "name": "PWWP2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SK59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ] }, { "name": "PWWP2A", "type": "synonym", "evidence": [ { "id": "XP_024851053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851053" } ] } ], "protein_names": [ { "name": "PWWP domain containing 2A", "type": "synonym", "evidence": [ { "id": "A0AAA9SK59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59/entry#names_and_taxonomy" } ] }, { "name": "PWWP domain-containing protein 2A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024851053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851053" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PWWP2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59", "locus": { "chromosome": "7", "start_pos": 71654763, "end_pos": 71688154, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010341", "url": "https://www.ensembl.org/id/ENSBTAG00000010341" } ] } } ], "crossref": [ { "id": "A0AAA9SK59", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK59", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20152", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20152", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540114", "url": "https://www.ncbi.nlm.nih.gov/gene/540114", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540114", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540114", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48125", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48125", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48125:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48125:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851053", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851053", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RTG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGEADGQQSSPQADEPPLPLPPPPPGELARSPEAAGLELEPEEKLPARVVEPGAAAPPEGPSLPPSPVPPPEEPPAPEERQEPPLPQPAAPALVPPAGGDSAVSQLIPGSEVRVTLDHIIEDALVVSFRLGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMQLQSNTFQEGTEVKCEVNGAVPNDPSPVPPPELSLAKSLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGGSASDPSKYEDKKRRSESVTTVNKKLKTDHKVDGRSQNESQKRSAVVKVSNIPHSRGRVVKVSAQANTSKAQLNTKKVLQNKNMDHAKAREVLKIAKEKAQKKQSETSTSRSAHSKVHFTRRYQNPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKMRSSKMAPKPQSRCTSTRSAGEAPSENQSPSTGPEEASSGVQDTTEVLVPGEQEEPQTLGRKGSKSSISVYMTLNQKKSDSSSASVCSIDSTDDLKSSNSECSSSESFDFPPGCMHAPSTSTSSSSKEEKKLSNSLKMKVFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDSGILVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFES", "length": 754, "header": "tr|A0AAA9SK59-1|A0AAA9SK59_BOVIN Isoform 1 of PWWP domain containing 2A OS=Bos taurus OX=9913 GN=PWWP2A PE=4 SV=1 CANONICAL=A0AAA9SK59-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59/entry#A0AAA9RTG8-1", "sequence": { "sequence": "MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGEADGQQSSPQADEPPLPLPPPPPGELARSPEAAGLELEPEEKLPARVVEPGAAAPPEGPSLPPSPVPPPEEPPAPEERQEPPLPQPAAPALVPPAGGDSAVSQLIPGSEVRVTLDHIIEDALVVSFRLGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMQLQSNTFQEGTEVKCEVNGAVPNDPSPVPPPELSLAKSLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGGSASDPSKYEDKKRRSESVTTVNKKLKTDHKVDGRSQNESQKRSAVVKVSNIPHSRGRVVKVSAQANTSKAQLNTKKVLQNKNMDHAKAREVLKIAKEKAQKKQSETSTSRSAHSKVHFTRRYQNPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKMRSSKMAPKPQSRCTSTRSAGLNKWQLLHQTVTSAAAPLQCLTDHCGFRLGALKLTVKRAAQRH", "length": 560, "header": "tr|A0AAA9RTG8-1|A0AAA9SK59_BOVIN Computationally mapped isoform of PWWP domain containing 2A OS=Bos taurus OX=9913 GN=PWWP2A PE=4 SV=1 CANONICAL=A0AAA9SK59-1" }, "locus": { "chromosome": "7", "start_pos": 71687955, "end_pos": 71655767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108167.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108167.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075184.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075184.1" } ] } }, { "isoform_ac": "A0AAA9SK59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59/entry#A0AAA9SK59-1", "sequence": { "sequence": "MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGEADGQQSSPQADEPPLPLPPPPPGELARSPEAAGLELEPEEKLPARVVEPGAAAPPEGPSLPPSPVPPPEEPPAPEERQEPPLPQPAAPALVPPAGGDSAVSQLIPGSEVRVTLDHIIEDALVVSFRLGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMQLQSNTFQEGTEVKCEVNGAVPNDPSPVPPPELSLAKSLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGGSASDPSKYEDKKRRSESVTTVNKKLKTDHKVDGRSQNESQKRSAVVKVSNIPHSRGRVVKVSAQANTSKAQLNTKKVLQNKNMDHAKAREVLKIAKEKAQKKQSETSTSRSAHSKVHFTRRYQNPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKMRSSKMAPKPQSRCTSTRSAGEAPSENQSPSTGPEEASSGVQDTTEVLVPGEQEEPQTLGRKGSKSSISVYMTLNQKKSDSSSASVCSIDSTDDLKSSNSECSSSESFDFPPGCMHAPSTSTSSSSKEEKKLSNSLKMKVFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDSGILVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFES", "length": 754, "header": "tr|A0AAA9SK59-1|A0AAA9SK59_BOVIN Isoform 1 of PWWP domain containing 2A OS=Bos taurus OX=9913 GN=PWWP2A PE=4 SV=1 CANONICAL=A0AAA9SK59-1" }, "locus": { "chromosome": "7", "start_pos": 71687955, "end_pos": 71669292, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128614.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128614.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084258.1" } ] } }, { "isoform_ac": "A0AAA9SR54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59/entry#A0AAA9SR54-1", "sequence": { "sequence": "MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGEADGQQSSPQADEPPLPLPPPPPGELARSPEAAGLELEPEEKLPARVVEPGAAAPPEGPSLPPSPVPPPEEPPAPEERQEPPLPQPAAPALVPPAGGDSAVSQLIPGSEVRVTLDHIIEDALVVSFRLGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMQLQSNTFQEGTEVKCEVNGAVPNDPSPVPPPELSLAKSLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGGSASDPSKYEDKKRRSESVTTVNKKLKTDHKVDGRSQNESQKRSAVVKVSNIPHSRGRVVKVSAQANTSKAQLNTKKVLQNKNMDHAKAREVLKIAKEKAQKKQSETSTSRSAHSKVHFTRRYQNPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKMRSSKMAPKPQSRCTSTRSAAQRH", "length": 520, "header": "tr|A0AAA9SR54-1|A0AAA9SR54_BOVIN Computationally mapped isoform of PWWP domain containing 2A OS=Bos taurus OX=9913 GN=PWWP2A PE=4 SV=1 CANONICAL=A0AAA9SK59-1" }, "locus": { "chromosome": "7", "start_pos": 71687955, "end_pos": 71655767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086537.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540114", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540114", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" }, { "name": "NuRD complex binding", "id": "GO:0120325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" }, { "name": "histone H3K36me3 reader activity", "id": "GO:0140003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140003", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" }, { "name": "positive regulation of transcription elongation by RNA polymerase II", "id": "GO:0032968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" }, { "name": "regulation of transcriptional start site selection at RNA polymerase II promoter", "id": "GO:0001178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" }, { "start_pos": 640, "end_pos": 642, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK59" }, { "id": "PS50812", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50812" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PWWP", "eco_id": "ECO_0000259", "start_pos": 654, "end_pos": 714, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 523, "end_pos": 525 }, { "start_pos": 640, "end_pos": 642 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKI3-1", "uniprot_ac": "A0AAA9SKI3", "uniprot_id": "A0AAA9SKI3_BOVIN", "mass": { "chemical_mass": 116225.0, "monoisotopic_mass": 116225.0 }, "refseq": { "ac": "XP_010800057", "name": "serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800057" }, "gene_names": [ { "name": "ANKRD28", "type": "recommended", "evidence": [ { "id": "A0AAA9SKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ] }, { "name": "ANKRD28", "type": "synonym", "evidence": [ { "id": "XP_010800057", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800057" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 28", "type": "synonym", "evidence": [ { "id": "A0AAA9SKI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010800057", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800057" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3", "locus": { "chromosome": "1", "start_pos": 152698434, "end_pos": 152916344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024815", "url": "https://www.ensembl.org/id/ENSBTAG00000024815" } ] } } ], "crossref": [ { "id": "A0AAA9SKI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024815", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024815", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529062", "url": "https://www.ncbi.nlm.nih.gov/gene/529062", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529062", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529062", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AMDGHTD", "url": "https://omabrowser.org/oma/group/AMDGHTD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BN43", "url": "https://www.orthodb.org/?gene=E1BN43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24198:SF192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24198:SF192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-171319", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010800057", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800057", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RTH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2V3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5G1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T784", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T784", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T784-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T784-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN43", "url": "https://www.uniprot.org/uniprotkb/E1BN43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN43-1", "url": "https://www.uniprot.org/uniprotkb/E1BN43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRVCIVVLEEVEDESPEFICKLPQENKSLHSAPSGNVLPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1083, "header": "tr|A0AAA9SKI3-1|A0AAA9SKI3_BOVIN Isoform 1 of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9RTH2-1", "sequence": { "sequence": "MSACNCCFLTCVHVLRRQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1034, "header": "tr|A0AAA9RTH2-1|A0AAA9SKI3_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152814829, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122525.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122525.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075190.1" } ] } }, { "isoform_ac": "A0AAA9S2V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9S2V3-1", "sequence": { "sequence": "MDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1017, "header": "tr|A0AAA9S2V3-1|A0AAA9SKI3_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152856658, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130864.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130864.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079401.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079401.1" } ] } }, { "isoform_ac": "A0AAA9SJ02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9SJ02-1", "sequence": { "sequence": "MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1053, "header": "tr|A0AAA9SJ02-1|A0AAA9SJ02_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152916145, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093939.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093939.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083899.1" } ] } }, { "isoform_ac": "A0AAA9SJJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9SJJ5-1", "sequence": { "sequence": "MAFLKLRDQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1025, "header": "tr|A0AAA9SJJ5-1|A0AAA9SJJ5_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152916145, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083981.1" } ] } }, { "isoform_ac": "A0AAA9SKI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9SKI3-1", "sequence": { "sequence": "MSRVCIVVLEEVEDESPEFICKLPQENKSLHSAPSGNVLPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1083, "header": "tr|A0AAA9SKI3-1|A0AAA9SKI3_BOVIN Isoform 1 of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152826230, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130471.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130471.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085803.1" } ] } }, { "isoform_ac": "A0AAA9SUA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9SUA9-1", "sequence": { "sequence": "MPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1045, "header": "tr|A0AAA9SUA9-1|A0AAA9SUA9_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152856658, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119783.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119783.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088920.1" } ] } }, { "isoform_ac": "A0AAA9T5G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9T5G1-1", "sequence": { "sequence": "MSRVCIVVLEEVEDESPEFICKLPQENKSLHSAPSGNVLPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1016, "header": "tr|A0AAA9T5G1-1|A0AAA9T5G1_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152826230, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107148.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107148.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093061.1" } ] } }, { "isoform_ac": "A0AAA9T784-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#A0AAA9T784-1", "sequence": { "sequence": "MGVRDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1020, "header": "tr|A0AAA9T784-1|A0AAA9T784_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=1 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152807535, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092462.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092462.1" } ] } }, { "isoform_ac": "E1BN43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3/entry#E1BN43-1", "sequence": { "sequence": "MSLSKLQELPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHTAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAALSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLNDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDRWGRTALHRGAVTGHEECVDALLQHGANCLFRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAMVDNHGYTALHWACYNGHETCVELLLEQDVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGSSIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAHVNSVDSSGKTPLMMAAENGQTNTVEMLVSSASADLTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPISSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1053, "header": "tr|E1BN43-1|A0AAA9SKI3_BOVIN Computationally mapped isoform of Ankyrin repeat domain 28 OS=Bos taurus OX=9913 GN=ANKRD28 PE=4 SV=2 CANONICAL=A0AAA9SKI3-1" }, "locus": { "chromosome": "1", "start_pos": 152833098, "end_pos": 152701414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034553.5", "url": "https://www.ensembl.org/id/ENSBTAT00000034553.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034443.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034443.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529062", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529062", "resource": "KEGG Pathway" }, { "id": "R-BTA-171319", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "resource": "Reactome", "description": "Telomere Extension By Telomerase" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6APS9-1", "protein_name": "Ankyrin repeat domain 28", "gene_name": "Ankrd28", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCTSPGFLHFSYLHTIHQDCLDLEYCCYSFEEKRPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQILLKHSADVNARDKNWQTPLHIAAANKAVKCAESLVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGANVNQKNERGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSATSVDANPAIVDNHGYTALHWACYNGHETCVELLLEQDVFQKIDGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAPDSKGRTPLHAAAFTDHVECLQLLLSQNAQVNSADSTGKTPLMMAAENGQTNTVEMLVSSASADLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSNSPLTSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1078 }, "evidence": [ { "id": "A0AAA9SKI3", "url": "https://omabrowser.org/oma/group/A0AAA9SKI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0X8A2-1", "protein_name": "Ankyrin repeat domain 28", "gene_name": "ANKRD28", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRVCIVVLEEEEDDCPTFVSSIPQENVCLRPLPPGNVLPPLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEDAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHVEMVSLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVAHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDSGANVNQMNEKGFTPLHFAAASTHGALCLELLVCNGADVNMKSKDGKTPLHMTAIHGRFSRSQTIIQNGAEIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDRFGRTPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAASDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLELIASETPLDVLMETSGTDMLNDSDNRAPISPLHLAAYHGHHQALEVLVQSLLDLDVRNNNGRTPLDLAAFKGHVECVDVLINQGASILVKDYVVKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVEALLQHGAKSLLRDCRGRTPIHLSAACGHIGVLGALLQSATSVDAIPAIADNHGYTSLHWACYNGHDSCVELLLEQEVFQKMEGNSFSPLHCAVINDNEGAAEMLIDTLGAGIVNSTDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNAVDASGKTPLMMAAENGQTNTVEVLVSSAKADLTLQDSCKNTALHLACSKGHETSALLILEKITDRNLINATNTALQTPLHVAARNGLTVVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSTLPSLTFNAINHYTNTSKTVTFDSLPIVRSDHSSYCTFNNIGREDGYPYTEEDELNDSDSETY", "length": 1083 }, "evidence": [ { "id": "A0AAA9SKI3", "url": "https://omabrowser.org/oma/group/A0AAA9SKI3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9QBZ2-1", "protein_name": "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A", "gene_name": "ankrd28b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVVLKIRDQPALLKAIFNVDPDEVRSLIFKKEDVNVQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDNKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHVAAANKAVRCAEALVPLLSNVNVSDRAGRTALHHAAFSGHLEMVRLLLSRGANINAFDKKDRRAIHWAAYMGHMEVVKLLVSHGAEVPCKDKKAYTPLHAAASSGMISVVKYLLDMGVDMNEPNAYGNTPLHVACYNGQDVVVNELIECGANVNQVNEKGFAPLHFTAASRHGALCLELLVGNGADVNIKSKDGKTPLHMTAIHGRFSRSQAIIQNGAEIDCEDKNGNTPLHIAARYGHELLINTLITNGADTAKRGVHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNRKDSFGRTPLHYAAANCNYQCLFALVGSGANVNELDKRGCTPLHYAAASDADGKCLEYLLRNDANPGIRDNQGYNAVHYASAYGHRLCLELIASETPLDVLMETSGTDILNDSDVLAPVSPLHLAAYHGHHQALEVLVQSLLDLDVRTAQGHTPLDLAAFKGHVECVDVLINQGASILVKDYTLKRTPIHAAATNGHSECLRLLIGNADLQSAVDIQDGIGQTPLMLSVLGGHTDCVYSLINKGANVDAKDKWGRTALHRGAVTGHEECVEALLQHSASFMVRDCRGRSPVHLASACGHVGVLGGLLHAAQSVESIPVITDHQGYTPLHWACYNGHDTCVEVLLEQELFHKTEGNPFSPLHCAVINDNEGAVELLIETLSPVIVNANDSKNRTPLHAAAFTDHVECLQLLLGHNAQVNCVDAGGKTPLMMAAENGQTNAVEVLVSSAKADLTLQDANKNTALHLACSKGHETSALLILEKITDRNLINSTNAALQTPLHVAARNGLTVVVQELLAKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSPGGGSVPTLTFSAINHYTSPTKSVTFDSLPMLRSEHSSYCSFNSIGRHDGFYKDEELNDSDSETY", "length": 1052 }, "evidence": [ { "id": "A0AAA9SKI3", "url": "https://omabrowser.org/oma/group/A0AAA9SKI3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O15084-3", "protein_name": "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A", "gene_name": "ANKRD28", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1053 }, "evidence": [ { "id": "A0AAA9SKI3", "url": "https://omabrowser.org/oma/group/A0AAA9SKI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q505D1-1", "protein_name": "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A", "gene_name": "Ankrd28", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQILLKHSADVNARDKNWQTPLHIAAANKAVKCAESLVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSATSVDANPAVVDNHGYTALHWACYNGHETCVELLLEQDVFQKIDGNAFSPLHCAVINDNEGAAEMLIDSLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSQNAQVNSADSTGKTPLMMAAENGQTNTVEMLVSSASADLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLTSLTFNAINRYTNTSKTVSFEALPIMRNEASSYCSFNNIGGEQEYLYTDVDELNDSDSETY", "length": 1053 }, "evidence": [ { "id": "A0AAA9SKI3", "url": "https://omabrowser.org/oma/group/A0AAA9SKI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase complex", "id": "GO:0008287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of focal adhesion assembly", "id": "GO:0051894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1035, "end_pos": 1037, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1076, "end_pos": 1078, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 573, "end_pos": 575, "annotation": "n_glycosylation_sequon" }, { "start_pos": 610, "end_pos": 612, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" }, { "start_pos": 950, "end_pos": 952, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1035, "end_pos": 1037 }, { "start_pos": 1076, "end_pos": 1078 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 27, "end_pos": 29 }, { "start_pos": 573, "end_pos": 575 }, { "start_pos": 610, "end_pos": 612 }, { "start_pos": 847, "end_pos": 849 }, { "start_pos": 950, "end_pos": 952 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK64-1", "uniprot_ac": "A0AAA9SK64", "uniprot_id": "A0AAA9SK64_BOVIN", "mass": { "chemical_mass": 72089.0, "monoisotopic_mass": 72089.0 }, "refseq": { "ac": "XP_005217988", "name": "F-box only protein 21 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217988" }, "gene_names": [ { "name": "FBXO21", "type": "recommended", "evidence": [ { "id": "A0AAA9SK64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64" } ] }, { "name": "FBXO21", "type": "synonym", "evidence": [ { "id": "XP_005217988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217988" } ] } ], "protein_names": [ { "name": "F-box only protein 21 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005217988", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217988" } ] }, { "name": "F-box protein 21", "type": "synonym", "evidence": [ { "id": "A0AAA9SK64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64", "locus": { "chromosome": "17", "start_pos": 57937005, "end_pos": 57892483, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032097", "url": "https://www.ensembl.org/id/ENSBTAG00000032097" } ] } } ], "crossref": [ { "id": "A0AAA9SK64", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK64", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617252", "url": "https://www.ncbi.nlm.nih.gov/gene/617252", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032698", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31350", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31350", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31350:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31350:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08755", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08755", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13369", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13369", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217988", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217988", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SG14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVVDSAMEVVPALVEEAAPEAAGLSCLVNLPGEVLEYILCSGSLTAADIGRVSSTCRRLRELCQGSGKVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQAQIDSIVELVCKTLRGINSRHPSLAFKAGESSMIMEIELQSQVLDAMNHVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGTTLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNLLSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSHEKHRDVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLESVYETVQNIYSAKKENVE", "length": 627, "header": "tr|A0AAA9SK64-1|A0AAA9SK64_BOVIN Isoform 1 of F-box protein 21 OS=Bos taurus OX=9913 GN=FBXO21 PE=4 SV=2 CANONICAL=A0AAA9SK64-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64/entry#A0AAA9SG14-1", "sequence": { "sequence": "MLCSTGHLDPDAEGERSDMDGNRFQFCRNAWMGSPSKAGTTGKEARWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQAQIDSIVELVCKTLRGINSRHPSLAFKAGESSMIMEIELQSQVLDAMNHVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGTTLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNLLSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSHEKHRDVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLESVYETVQNIYSAKKENVE", "length": 593, "header": "tr|A0AAA9SG14-1|A0AAA9SK64_BOVIN Computationally mapped isoform of F-box protein 21 OS=Bos taurus OX=9913 GN=FBXO21 PE=4 SV=1 CANONICAL=A0AAA9SK64-1" }, "locus": { "chromosome": "17", "start_pos": 57936001, "end_pos": 57899446, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104288.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104288.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084312.1" } ] } }, { "isoform_ac": "A0AAA9SK64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64/entry#A0AAA9SK64-1", "sequence": { "sequence": "MAAAVVDSAMEVVPALVEEAAPEAAGLSCLVNLPGEVLEYILCSGSLTAADIGRVSSTCRRLRELCQGSGKVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKVRQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKALTWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQAQIDSIVELVCKTLRGINSRHPSLAFKAGESSMIMEIELQSQVLDAMNHVLYDQLKFKGNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQGAEGTTLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNLLSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKSFCLVLKVLDILQHIQTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSHEKHRDVCYSIGLIMKHKRYGYNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVEPQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLESVYETVQNIYSAKKENVE", "length": 627, "header": "tr|A0AAA9SK64-1|A0AAA9SK64_BOVIN Isoform 1 of F-box protein 21 OS=Bos taurus OX=9913 GN=FBXO21 PE=4 SV=2 CANONICAL=A0AAA9SK64-1" }, "locus": { "chromosome": "17", "start_pos": 57936001, "end_pos": 57900950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133529.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133529.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084263.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084263.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK64" }, { "id": "SM00992", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00992" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Hemimethylated DNA-binding", "eco_id": "ECO_0000259", "start_pos": 500, "end_pos": 597, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMN7-1", "uniprot_ac": "A0AAA9SMN7", "uniprot_id": "A0AAA9SMN7_BOVIN", "mass": { "chemical_mass": 26718.0, "monoisotopic_mass": 26718.0 }, "refseq": { "ac": "XP_059745853", "name": "protein lin-28 homolog B isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745853" }, "gene_names": [ { "name": "LIN28B", "type": "recommended", "evidence": [ { "id": "A0AAA9SMN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ] }, { "name": "LIN28B", "type": "synonym", "evidence": [ { "id": "XP_059745853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745853" } ] } ], "protein_names": [ { "name": "Lin-28 homolog B", "type": "synonym", "evidence": [ { "id": "A0AAA9SMN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7/entry#names_and_taxonomy" } ] }, { "name": "protein lin-28 homolog B isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059745853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745853" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LIN28B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7", "locus": { "chromosome": "9", "start_pos": 44947436, "end_pos": 45086340, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000043973", "url": "https://www.ensembl.org/id/ENSBTAG00000043973" } ] } } ], "crossref": [ { "id": "A0AAA9SMN7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000043973", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043973", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04458", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04458", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112448101", "url": "https://www.ncbi.nlm.nih.gov/gene/112448101", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46109", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46109", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46109:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46109:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00313", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00313", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21890", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21890", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059745853", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RW46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T395", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T395", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T395-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T395-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N777", "url": "https://www.uniprot.org/uniprotkb/F1N777", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N777-1", "url": "https://www.uniprot.org/uniprotkb/F1N777-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGGAGKGGGEEPGKLPEQAEDESQVLHGTGHCKWFNVRMGFGFISMISREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHCCQSITHMVANCPHKTAVQPPASSQGRQEAEPQPCTSTFPREVGGGHSCTSFQEARSELSEWPGRSPQEASSTKSSAAPEEQSKKGPSVQKRKKT", "length": 247, "header": "tr|A0AAA9SMN7-1|A0AAA9SMN7_BOVIN Isoform 1 of Lin-28 homolog B OS=Bos taurus OX=9913 GN=LIN28B PE=3 SV=1 CANONICAL=A0AAA9SMN7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RW46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7/entry#A0AAA9RW46-1", "sequence": { "sequence": "MRSFNQVSSAPGGAGKGGGEEPGKLPEQAEDESQVLHGTGHCKWFNVRMGFGFISMISREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDSISSYGGLLATSSLRCYNCGGLDHHAKECSLPPQPKKCHCCQSITHMVANCPHKTAVQPPASSQGRQEAEPQPCTSTFPREVGGGHSCTSFQEARSELSEWPGRSPQEASSTKSSAAPEEQSKKGPSVQKRKKT", "length": 269, "header": "tr|A0AAA9RW46-1|A0AAA9SMN7_BOVIN Computationally mapped isoform of Lin-28 homolog B OS=Bos taurus OX=9913 GN=LIN28B PE=3 SV=1 CANONICAL=A0AAA9SMN7-1" }, "locus": { "chromosome": "9", "start_pos": 45077229, "end_pos": 44948440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096065.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096065.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075334.1" } ] } }, { "isoform_ac": "A0AAA9SMN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7/entry#A0AAA9SMN7-1", "sequence": { "sequence": "MAEGGAGKGGGEEPGKLPEQAEDESQVLHGTGHCKWFNVRMGFGFISMISREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHCCQSITHMVANCPHKTAVQPPASSQGRQEAEPQPCTSTFPREVGGGHSCTSFQEARSELSEWPGRSPQEASSTKSSAAPEEQSKKGPSVQKRKKT", "length": 247, "header": "tr|A0AAA9SMN7-1|A0AAA9SMN7_BOVIN Isoform 1 of Lin-28 homolog B OS=Bos taurus OX=9913 GN=LIN28B PE=3 SV=1 CANONICAL=A0AAA9SMN7-1" }, "locus": { "chromosome": "9", "start_pos": 45069956, "end_pos": 44948440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092997.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092997.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084030.1" } ] } }, { "isoform_ac": "A0AAA9T395-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7/entry#A0AAA9T395-1", "sequence": { "sequence": "MAEGGAGKGGGEEPGKLPEQAEDESQVLHGTGHCKWFNVRMGFGFISMISREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDSISSYGGLLATSSLRCYNCGGLDHHAKECSLPPQPKKCHCCQSITHMVANCPHKTAVQPPASSQGRQEAEPQPCTSTFPREVGGGHSCTSFQEARSELSEWPGRSPQEASSTKSSAAPEEQSKKGPSVQKRKKT", "length": 261, "header": "tr|A0AAA9T395-1|A0AAA9T395_BOVIN Computationally mapped isoform of Lin-28 homolog B OS=Bos taurus OX=9913 GN=LIN28B PE=3 SV=1 CANONICAL=A0AAA9SMN7-1" }, "locus": { "chromosome": "9", "start_pos": 45069956, "end_pos": 44948440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123716.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123716.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092232.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092232.1" } ] } }, { "isoform_ac": "F1N777-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7/entry#F1N777-1", "sequence": { "sequence": "MVPQPLLLVLRRTEALFQLYRSHSLLLLENNNGGAGKGGGEEPGKLPEQAEDESQVLHGTGHCKWFNVRMGFGFISMISREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHCCQSITHMVANCPHKTAVQPPASSQGRQEAEPQPCTSTFPREVGGGHSCTSFQEARSELSEWPGRSPQEASSTKSSAAPEEQSKKGPSVQKRKKT", "length": 276, "header": "tr|F1N777-1|F1N777_BOVIN Computationally mapped isoform of Lin-28 homolog B OS=Bos taurus OX=9913 GN=LIN28B PE=3 SV=4 CANONICAL=A0AAA9SMN7-1" }, "locus": { "chromosome": "9", "start_pos": 45073406, "end_pos": 44948440, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061356.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061356.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053651.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053651.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of miRNA-mediated gene silencing", "id": "GO:0060964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060964", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "post-transcriptional regulation of gene expression", "id": "GO:0010608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010608", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "pre-miRNA processing", "id": "GO:0031054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "miRNA catabolic process", "id": "GO:0010587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010587", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "RNA destabilization", "id": "GO:0050779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "negative regulation of primary miRNA processing", "id": "GO:2000635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "positive regulation of miRNA catabolic process", "id": "GO:2000627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000627", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "negative regulation of pre-miRNA processing", "id": "GO:2000632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000632", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" }, { "name": "RNA 3'-end processing", "id": "GO:0031123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" }, { "id": "PS50158", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC-type", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 142, "start_aa": "Arg", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN7" }, { "id": "PS51857", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51857" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CSD", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 101, "start_aa": "His", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJW6-1", "uniprot_ac": "A0AAA9SJW6", "uniprot_id": "A0AAA9SJW6_BOVIN", "mass": { "chemical_mass": 125956.0, "monoisotopic_mass": 125956.0 }, "refseq": { "ac": "XP_024856240", "name": "solute carrier family 12 member 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856240" }, "gene_names": [ { "name": "SLC12A5", "type": "recommended", "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ] }, { "name": "SLC12A5", "type": "synonym", "evidence": [ { "id": "XP_024856240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856240" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 5", "type": "recommended", "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#names_and_taxonomy" } ] }, { "name": "Electroneutral potassium-chloride cotransporter 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#names_and_taxonomy" } ] }, { "name": "K-Cl cotransporter 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#names_and_taxonomy" } ] }, { "name": "Neuronal K-Cl cotransporter", "type": "synonym", "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 12 member 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856240" } ] } ], "function": [ { "annotation": "Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RWQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ9#function" }, { "database": "UniProtKB", "id": "ARBA00058031", "url": "https://www.uniprot.org/uniprotkb/ARBA00058031#function" }, { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6", "locus": { "chromosome": "13", "start_pos": 74795844, "end_pos": 74759175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014179", "url": "https://www.ensembl.org/id/ENSBTAG00000014179" } ] } } ], "crossref": [ { "id": "A0AAA9SJW6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "510157", "url": "https://www.ncbi.nlm.nih.gov/gene/510157", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856240", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856240", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72427", "url": "https://www.rhea-db.org/rhea/72427", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RWQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK95", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK95-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRFTVTSLPPAGPAGASDPGPHGPSAADRRRRLSGGDAKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIIEAFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFMRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSAGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEVEGEADPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSQDAKLVLLNMPGPPRNRNGDENYMEFLEVLTERLDRVMLVRGGGREVITIYS", "length": 1140, "header": "tr|A0AAA9SJW6-1|A0AAA9SJW6_BOVIN Isoform 1 of Solute carrier family 12 member 5 OS=Bos taurus OX=9913 GN=SLC12A5 PE=3 SV=1 CANONICAL=A0AAA9SJW6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#A0AAA9RWQ9-1", "sequence": { "sequence": "MSRRFTVTSLPPAGPAGASDPGPHGPSAADRRRRLSGGDAKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIIEAFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFMRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSAGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEVEGEADPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPNQSNVRRMHTAVRLNEVIVKKSQDAKLVLLNMPGPPRNRNGDENYMEFLEVLTERLDRVMLVRGGGREVITIYS", "length": 1135, "header": "tr|A0AAA9RWQ9-1|A0AAA9SJW6_BOVIN Computationally mapped isoform of Solute carrier family 12 member 5 OS=Bos taurus OX=9913 GN=SLC12A5 PE=3 SV=1 CANONICAL=A0AAA9SJW6-1" }, "locus": { "chromosome": "13", "start_pos": 74793336, "end_pos": 74759284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105320.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105320.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075555.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075555.1" } ] } }, { "isoform_ac": "A0AAA9SJW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#A0AAA9SJW6-1", "sequence": { "sequence": "MSRRFTVTSLPPAGPAGASDPGPHGPSAADRRRRLSGGDAKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIIEAFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFMRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSAGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEVEGEADPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSQDAKLVLLNMPGPPRNRNGDENYMEFLEVLTERLDRVMLVRGGGREVITIYS", "length": 1140, "header": "tr|A0AAA9SJW6-1|A0AAA9SJW6_BOVIN Isoform 1 of Solute carrier family 12 member 5 OS=Bos taurus OX=9913 GN=SLC12A5 PE=3 SV=1 CANONICAL=A0AAA9SJW6-1" }, "locus": { "chromosome": "13", "start_pos": 74793336, "end_pos": 74759284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129211.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129211.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084129.1" } ] } }, { "isoform_ac": "A0ABI0NK95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6/entry#A0ABI0NK95-1", "sequence": { "sequence": "MLNNLTDCEDGDGGANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIIEAFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRLSGWQEFH", "length": 178, "header": "tr|A0ABI0NK95-1|A0ABI0NK95_BOVIN Computationally mapped isoform of Solute carrier family 12 member 5 OS=Bos taurus OX=9913 GN=SLC12A5 PE=4 SV=1 CANONICAL=A0AAA9SJW6-1" }, "locus": { "chromosome": "13", "start_pos": 74795346, "end_pos": 74767061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145994.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145994.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105051.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "postsynaptic specialization membrane", "id": "GO:0099634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "potassium:chloride symporter activity", "id": "GO:0015379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015379", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "chloride:monoatomic cation symporter activity", "id": "GO:0015377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015377", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "intracellular chloride ion homeostasis", "id": "GO:0030644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030644", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "dendritic spine development", "id": "GO:0060996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060996", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" }, { "name": "hypotonic response", "id": "GO:0006971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006971", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1067, "end_pos": 1069, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 834, "end_pos": 836, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72427", "name": "", "equation": "K(+)(in) + chloride(in) = K(+)(out) + chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72427" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 127, "end_pos": 299, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW6" }, { "id": "PF03522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SLC12A transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 713, "end_pos": 831, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1067, "end_pos": 1069 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 834, "end_pos": 836 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKR9-1", "uniprot_ac": "A0AAA9SKR9", "uniprot_id": "A0AAA9SKR9_BOVIN", "mass": { "chemical_mass": 55938.0, "monoisotopic_mass": 55938.0 }, "refseq": {}, "gene_names": [ { "name": "SLC18A1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ] } ], "protein_names": [ { "name": "Solute carrier family 18 member A1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC18A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9", "locus": { "chromosome": "8", "start_pos": 67229792, "end_pos": 67282360, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020788", "url": "https://www.ensembl.org/id/ENSBTAG00000020788" } ] } } ], "crossref": [ { "id": "A0AAA9SKR9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020788", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020788", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17384", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17384", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FGWCVDR", "url": "https://omabrowser.org/oma/group/FGWCVDR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBH3", "url": "https://www.orthodb.org/?gene=F1MBH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23506", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23506", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23506:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23506:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "73739", "url": "https://www.rhea-db.org/rhea/73739", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "73743", "url": "https://www.rhea-db.org/rhea/73743", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RX07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBH3", "url": "https://www.uniprot.org/uniprotkb/F1MBH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBH3-1", "url": "https://www.uniprot.org/uniprotkb/F1MBH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRTVLDAPQRLLKKGRESRKLVLLVVFVALLLDNMLLTVVVPIVPTYLYAIEFKDINGSLYLGSATTTQPSLTPAFSTILSFFENNTVAVEESVPSGIARTSSISGTIPPVTEAIPAHGNNCFQATEFLKEENLWVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFISTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLACVYTDDHERGRAMGIALGGLALGVLVGAPFGSVTYVFLGKTVPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLLTLLRDPYILVAAGSICLANMGVAMLEPTLPIWMLQTMCAPEWQLGLAFLPASVSYLIGTSLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHDIFGLIGPNAGLGISIGMVDSSMMPIMGHLVDLRHAPVYGSVYAIADVAFCLGFAVGPSTGGAIVRAIGFPWLMVITGVTDIIYAPLCYYLRSPPAKEEKLAVLSQDCPMETRMYAAEKHTRQFPLGEDSDEEPGCEE", "length": 523, "header": "tr|A0AAA9SKR9-1|A0AAA9SKR9_BOVIN Isoform 1 of Solute carrier family 18 member A1 OS=Bos taurus OX=9913 GN=SLC18A1 PE=3 SV=1 CANONICAL=A0AAA9SKR9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RX07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9/entry#A0AAA9RX07-1", "sequence": { "sequence": "MLRTVLDAPQRLLKKGRESRKLVLLVVFVALLLDNMLLTVVVPIVPTYLYAIEFKDINGSLYLGSATTTQPSLTPAFSTILSFFENNTVAVEESVPSGIARTSSISGTIPPVTEAIPAHGNNCFQATEFLKEENLWVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFISTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLACVYTDDHERGRAMGIALGGLALGVLVGAPFGSVTYVFLGKTVPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLLTLLRDPYILVAAGSICLANMGVAMLEPTLPIWMLQTMCAPEWQLGLAFLPASVSYLIGTSLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHDIFGLIGPNAGLGISIGMVDSSMMPIMGHLVDLRHAPVYGSVYAIADVAFCLGFAVPHGDPDVCSREAHKAVSSGGGQR", "length": 464, "header": "tr|A0AAA9RX07-1|A0AAA9SKR9_BOVIN Computationally mapped isoform of Solute carrier family 18 member A1 OS=Bos taurus OX=9913 GN=SLC18A1 PE=3 SV=1 CANONICAL=A0AAA9SKR9-1" }, "locus": { "chromosome": "8", "start_pos": 67273780, "end_pos": 67230501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101138.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101138.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075689.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075689.1" } ] } }, { "isoform_ac": "A0AAA9SKR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9/entry#A0AAA9SKR9-1", "sequence": { "sequence": "MLRTVLDAPQRLLKKGRESRKLVLLVVFVALLLDNMLLTVVVPIVPTYLYAIEFKDINGSLYLGSATTTQPSLTPAFSTILSFFENNTVAVEESVPSGIARTSSISGTIPPVTEAIPAHGNNCFQATEFLKEENLWVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFISTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLACVYTDDHERGRAMGIALGGLALGVLVGAPFGSVTYVFLGKTVPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLLTLLRDPYILVAAGSICLANMGVAMLEPTLPIWMLQTMCAPEWQLGLAFLPASVSYLIGTSLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHDIFGLIGPNAGLGISIGMVDSSMMPIMGHLVDLRHAPVYGSVYAIADVAFCLGFAVGPSTGGAIVRAIGFPWLMVITGVTDIIYAPLCYYLRSPPAKEEKLAVLSQDCPMETRMYAAEKHTRQFPLGEDSDEEPGCEE", "length": 523, "header": "tr|A0AAA9SKR9-1|A0AAA9SKR9_BOVIN Isoform 1 of Solute carrier family 18 member A1 OS=Bos taurus OX=9913 GN=SLC18A1 PE=3 SV=1 CANONICAL=A0AAA9SKR9-1" }, "locus": { "chromosome": "8", "start_pos": 67273780, "end_pos": 67230479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132749.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132749.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085884.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085884.1" } ] } }, { "isoform_ac": "F1MBH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9/entry#F1MBH3-1", "sequence": { "sequence": "MLRTVLDAPQRLLKKGRESRKLVLLVVFVALLLDNMLLTVVVPIVPTYLYAIEFKDINGSLYLGSATTTQPSLTPAFSTILSFFENNTVAVEESVPSGIARTSSISGTIPPVTEAIPAHGNNCFQATEFLKEENLWVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFISTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLACVYTDDHERGRAMGIALGGLALGVLVGAPFGSVTYVFLGKTVPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLLTLLRDPYILVAAGLAFLPASVSYLIGTSLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHDIFGLIGPNAGLGISIGMVDSSMMPIMGHLVDLRHAPVYGSVYAIADVAFCLGFAVGPSTGGAIVRAIGFPWLMVITGVTDIIYAPLCYYLRSPPAKEEKLPMETRMYAAEKHTRQFPLGEDSDEEPGCEE", "length": 484, "header": "tr|F1MBH3-1|F1MBH3_BOVIN Computationally mapped isoform of Solute carrier family 18 member A1 OS=Bos taurus OX=9913 GN=SLC18A1 PE=3 SV=4 CANONICAL=A0AAA9SKR9-1" }, "locus": { "chromosome": "8", "start_pos": 67273780, "end_pos": 67230479, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045811.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045811.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043172.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043172.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RG90-1", "protein_name": "Solute carrier family 18 member A1", "gene_name": "SLC18A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRAVWDAPQQLLKKGRGSPKLVLLVVFVALLLDNMLLTVVVPIVPTYLYAIEFKDVNTSLYLGPTSTTQPALASAFSTIFSFFENNTVAIEESVPSGTAWTNGTSGTTPPPVTEAIATHKNNCFQGTEFLKEENIWVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFMSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGKAMGIALGGLALGVLVGAPFGSVMYVFFGKVVPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLLTLLQDPYILVAAGSLCFANMGVAMLEPTLPIWMLQTMCPPEWHLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLVGMVIVGTSLLCVPLAHNIFGLIGPNAGLGFSIGMVDSSMMPIMGHLVDLRHAPVYGSVYAIADVAFCMGFAIGPSTGGAIVRAIGFPWLMVIIGVVNIIYAPLCCYLRSPPAKEEKLAILSQDCPLETRMYAAEPHLREFPLGDDSDAEPASEE", "length": 524 }, "evidence": [ { "id": "A0AAA9SKR9", "url": "https://omabrowser.org/oma/group/A0AAA9SKR9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MMN4-1", "protein_name": "Chromaffin granule amine transporter isoform X1", "gene_name": "Slc18a1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFQVVLGAPQRLLKEGRESRQLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFRDVNSSLHRGPSVRSQQAVTSPDFSTIFSFFDNTTTTAEAHVLFHVAWTNGTIPPPVTEAGSAPKNSCLQGIEFLEEENIRVGVLFASKALMQLLVNPFVGPLTNRIGYHIPMFAGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNHERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILWPSKVSSENAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCALVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCIGFAIGPSTGGAVVQVIGFPWLMVVIGVINIIYAPLCCFLQNPPAKEEKLAILSQECPMETQMYASRKPTKEFPLGDNSDDPGSEE", "length": 521 }, "evidence": [ { "id": "A0AAA9SKR9", "url": "https://omabrowser.org/oma/group/A0AAA9SKR9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P54219-1", "protein_name": "Chromaffin granule amine transporter", "gene_name": "SLC18A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISAHKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE", "length": 525 }, "evidence": [ { "id": "A0AAA9SKR9", "url": "https://omabrowser.org/oma/group/A0AAA9SKR9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q01818-1", "protein_name": "Chromaffin granule amine transporter", "gene_name": "Slc18a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDSNSSLHRGPSVSSQQALTSPAFSTIFSFFDNTTTTVEEHVPFRVTWTNGTIPPPVTEASSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILWPSKVSPESAMGTSLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVQVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEKRAILSQECPTETQMYTFQKPTKAFPLGENSDDPSSGE", "length": 521 }, "evidence": [ { "id": "A0AAA9SKR9", "url": "https://omabrowser.org/oma/group/A0AAA9SKR9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R090-1", "protein_name": "Chromaffin granule amine transporter", "gene_name": "Slc18a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDINSSLLRGPSVSSQQALTSPAFSTTFSFFDNTTMTVEEHVPFRVAWINGTIPPPVTEAGSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEELAILNQECPTETQMYTIQRPTKEFPLGENSDDPGSEE", "length": 521 }, "evidence": [ { "id": "A0AAA9SKR9", "url": "https://omabrowser.org/oma/group/A0AAA9SKR9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" }, { "name": "serotonin:sodium:chloride symporter activity", "id": "GO:0005335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" }, { "name": "terminal bouton", "id": "GO:0043195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043195", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "establishment of localization in cell", "id": "GO:0051649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051649", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" }, { "name": "serotonin transport", "id": "GO:0006837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" }, { "name": "neurotransmitter transport", "id": "GO:0006836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006836", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" }, { "name": "aminergic neurotransmitter loading into synaptic vesicle", "id": "GO:0015842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015842", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "73739", "name": "", "equation": "dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "73739", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/73739" } ] }, { "id": "73743", "name": "", "equation": "serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "73743", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/73743" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR9" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 481, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 58, "end_pos": 60 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKI1-1", "uniprot_ac": "A0AAA9SKI1", "uniprot_id": "A0AAA9SKI1_BOVIN", "mass": { "chemical_mass": 23405.0, "monoisotopic_mass": 23405.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD37", "type": "recommended", "evidence": [ { "id": "A0AAA9SKI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 37", "type": "synonym", "evidence": [ { "id": "A0AAA9SKI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1", "locus": { "chromosome": "27", "start_pos": 15654048, "end_pos": 15646411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018453", "url": "https://www.ensembl.org/id/ENSBTAG00000018453" } ] } } ], "crossref": [ { "id": "A0AAA9SKI1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "509139", "url": "https://www.ncbi.nlm.nih.gov/gene/509139", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24201:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24201:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RX71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z560", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z560", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z560-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z560-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VKPLQSWRVFGVAEDFNLRRAGAWTKARRGAGAVLFSQVDSLKHLLETGASVNAPPDPCEQSPVHLAAGGGLACFLLWQLQTGADLNQQLPQAINLTHQLPQECFGETKICCLVCKDVFGEAPLHKAARVGSMECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPECAKFLTTIKCMQTIKSREQPNKDHCVQVLRLKRSFGSEEYTSGKRKC", "length": 214, "header": "tr|A0AAA9SKI1-1|A0AAA9SKI1_BOVIN Isoform 1 of Ankyrin repeat domain 37 OS=Bos taurus OX=9913 GN=ANKRD37 PE=4 SV=1 CANONICAL=A0AAA9SKI1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RX71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1/entry#A0AAA9RX71-1", "sequence": { "sequence": "GGWGEVDSLKHLLETGASVNAPPDPCEQSPVHLAAGGGLACFLLWQLQTGADLNQQLPQAINLTHQLPQECFGETKICCLVCKDVFGEAPLHKAARVGSMECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPECAKFLTTIKCMQTIKSREQPNKDHCVQVLRLKRSFGSEEYTSGKRKC", "length": 181, "header": "tr|A0AAA9RX71-1|A0AAA9SKI1_BOVIN Computationally mapped isoform of Ankyrin repeat domain 37 OS=Bos taurus OX=9913 GN=ANKRD37 PE=4 SV=1 CANONICAL=A0AAA9SKI1-1" }, "locus": { "chromosome": "27", "start_pos": 15653571, "end_pos": 15646429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104035.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104035.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075778.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075778.1" } ] } }, { "isoform_ac": "A0AAA9SKI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1/entry#A0AAA9SKI1-1", "sequence": { "sequence": "VKPLQSWRVFGVAEDFNLRRAGAWTKARRGAGAVLFSQVDSLKHLLETGASVNAPPDPCEQSPVHLAAGGGLACFLLWQLQTGADLNQQLPQAINLTHQLPQECFGETKICCLVCKDVFGEAPLHKAARVGSMECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPECAKFLTTIKCMQTIKSREQPNKDHCVQVLRLKRSFGSEEYTSGKRKC", "length": 214, "header": "tr|A0AAA9SKI1-1|A0AAA9SKI1_BOVIN Isoform 1 of Ankyrin repeat domain 37 OS=Bos taurus OX=9913 GN=ANKRD37 PE=4 SV=1 CANONICAL=A0AAA9SKI1-1" }, "locus": { "chromosome": "27", "start_pos": 15653571, "end_pos": 15651688, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134871.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134871.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084422.1" } ] } }, { "isoform_ac": "A0AAF6Z560-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1/entry#A0AAF6Z560-1", "sequence": { "sequence": "MLLLDCNPEVDSLKHLLETGASVNAPPDPCEQSPVHLAAGGGLACFLLWQLQTGADLNQQLPQAINLTHQLPQECFGETKICCLVCKDVFGEAPLHKAARVGSMECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPECAKFLTTIKCMQTIKSREQPNKDHCVQVLRLKRSFGSEEYTSGKRKC", "length": 185, "header": "tr|A0AAF6Z560-1|A0AAF6Z560_BOVIN Computationally mapped isoform of Ankyrin repeat domain 37 OS=Bos taurus OX=9913 GN=ANKRD37 PE=4 SV=1 CANONICAL=A0AAA9SKI1-1" }, "locus": { "chromosome": "27", "start_pos": 15653571, "end_pos": 15651553, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024559.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024559.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024559.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024559.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJG6-1", "uniprot_ac": "A0AAA9SJG6", "uniprot_id": "A0AAA9SJG6_BOVIN", "mass": { "chemical_mass": 151774.0, "monoisotopic_mass": 151774.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101906567", "type": "recommended", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] } ], "protein_names": [ { "name": "Multidrug resistance-associated protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.3", "type": "synonym", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules. Confers resistance to anticancer agents such as methotrexate.", "evidence": [ { "database": "UniProtKB", "id": "G3X810", "url": "https://www.uniprot.org/uniprotkb/G3X810#function" }, { "database": "UniProtKB", "id": "ARBA00094206", "url": "https://www.uniprot.org/uniprotkb/ARBA00094206#function" }, { "database": "UniProtKB", "id": "G5E5W7", "url": "https://www.uniprot.org/uniprotkb/G5E5W7#function" }, { "database": "UniProtKB", "id": "A0AAA9RYN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYN8#function" }, { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6#function" }, { "database": "UniProtKB", "id": "A0AAA9TFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFS8#function" }, { "database": "UniProtKB", "id": "G3MW11", "url": "https://www.uniprot.org/uniprotkb/G3MW11#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101906567", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000046041", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046041", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000047383", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047383", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3X810", "url": "https://www.orthodb.org/?gene=G3X810", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "66424", "url": "https://www.rhea-db.org/rhea/66424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RYN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MW11", "url": "https://www.uniprot.org/uniprotkb/G3MW11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MW11-1", "url": "https://www.uniprot.org/uniprotkb/G3MW11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X810", "url": "https://www.uniprot.org/uniprotkb/G3X810", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X810-1", "url": "https://www.uniprot.org/uniprotkb/G3X810-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5T3", "url": "https://www.uniprot.org/uniprotkb/G5E5T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5T3-1", "url": "https://www.uniprot.org/uniprotkb/G5E5T3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5W7", "url": "https://www.uniprot.org/uniprotkb/G5E5W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5W7-1", "url": "https://www.uniprot.org/uniprotkb/G5E5W7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEETFRVLLPRYFEDLLTHFQKFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVSKEICFGVIIFFSSLFHRANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVSAFAPHAFFSTENKIVIRTNQELTIPSHCSLNGA", "length": 1332, "header": "tr|A0AAA9SJG6-1|A0AAA9SJG6_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=1 CANONICAL=A0AAA9SJG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#A0AAA9RYN8-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEETFRVLLPRYFEDLLTHFQKFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVSKEICFGVIIFFSSLFHRANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVSAFAPHAFFSTENKIVIRTNQELTIPSHCSLNGA", "length": 1295, "header": "tr|A0AAA9RYN8-1|A0AAA9SJG6_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=1 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70681283, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127622.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127622.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078687.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078687.1" } ] } }, { "isoform_ac": "A0AAA9SJG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#A0AAA9SJG6-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEETFRVLLPRYFEDLLTHFQKFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVSKEICFGVIIFFSSLFHRANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVSAFAPHAFFSTENKIVIRTNQELTIPSHCSLNGA", "length": 1332, "header": "tr|A0AAA9SJG6-1|A0AAA9SJG6_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=1 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70681283, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091323.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091323.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082736.1" } ] } }, { "isoform_ac": "A0AAA9SWT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#A0AAA9SWT7-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEVKAFIYSPFFLSGFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVAYILQDWWLLNWANEQDTLNITAHEKGNITEMIHLDWYLGIFSGKAESSGRRKRFCCIFI", "length": 779, "header": "tr|A0AAA9SWT7-1|A0AAA9SWT7_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=4 SV=1 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70560909, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090937.1" } ] } }, { "isoform_ac": "A0AAA9TFS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#A0AAA9TFS8-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEETFRVLLPRYFEDLLTHFQKFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVSKEICFGVIIFFSSLFHRANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVYFKKSFRVPI", "length": 1308, "header": "tr|A0AAA9TFS8-1|A0AAA9TFS8_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=1 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70681581, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110254.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110254.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097415.1" } ] } }, { "isoform_ac": "G3MW11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#G3MW11-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEVKAFIYSPFFLSGFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVAYILQDWWLLNWANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVSPLWGVVIKIYLHSSLLTIW", "length": 1305, "header": "tr|G3MW11-1|G3MW11_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=2 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70680712, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035484.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035484.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035359.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035359.5" } ] } }, { "isoform_ac": "G3X810-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#G3X810-1", "sequence": { "sequence": "MCSLNLHLSSFLLIFNRWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEETFRVLLPRYFEDLLTHFQKFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVSKEICFGVIIFFSSLFHRANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSALNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVYFKKSFRVPI", "length": 1262, "header": "tr|G3X810-1|G3X810_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=3 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70681581, "end_pos": 70422251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050045.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050045.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046814.5", "url": "https://www.ensembl.org/id/ENSBTAP00000046814.5" } ] } }, { "isoform_ac": "G5E5T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#G5E5T3-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFETLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVSKEICFGVIIFFSSLFHRANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVSPLWGVVIKIYLHSSLLTIW", "length": 1243, "header": "tr|G5E5T3-1|G5E5T3_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=3 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70680712, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030481.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030481.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030462.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030462.6" } ] } }, { "isoform_ac": "G5E5W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6/entry#G5E5W7-1", "sequence": { "sequence": "MLQVFPERKPNPLQDANLCSRLVFWWINPLFKIGHKRRLEEDDMYSVLPEDRSQHVGEELQGYWDQEVKRAEKDAREPSLMKAIIKCYWKSYLPFAVFKLFEETFRVLLPRYFEDLLTHFQKFDPSDSGVLFKTYGYTAVLNLCLFIWSILVHFCFYYVQRVGMRLRVAMCHMIYCKTLRLSNSAIGKTTTGQIVNMMSNDVNRFDRVMIRLHILWIGPLNAITAIILLWMEIGISSLAGMALLIIFMLLQSFSGKLFLSLRSKSAAFTDTRLRTMNEVITGIRTIKMYAWEKLFAELITRLRRKEISKILRRSYLDGMNLIFFDTASKLILFITFTTYVLLGNTITVNQVFLAITLYQVVQFTGILLFPTAIENIAETVASVRRIKNFLLLDELPQCDHQLPLDGKTVVNVQDFTAFWDKELRTPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPSQGQVSVHGRIVYVSQQPWVFSGTVRSNILFGKKYEEERYEKVIKACALEEDLQFLENGDLTVVGDRGTTLSGGQKARVSLARALYQNADIYLLDDPLSAVDAEVSRHLFKQCICQGLHEKITILVTHQWQYLKDASQILVLEKGEMVQKGTYAELLKSGIDFASLLKKENEEAEPSPVPESPTMRTQTSSESSVQSQQSSTPLLKDAPAEDQDTENIQHTLSEERRLEGKVGFKTYKNYFRAGAHWSVIIFLILVNIAAQVAYILQDWWLLNWANEQDTLNITAHEKGNITEMIHLDWYLGIFSGLTASSLLFGVTRSLLALYILVNSSQTLHNKMLKSILRVPVLFFDRNPAGRILNRFSKDIGYMDDVLPSSFQKFFQTFLQVIGVVVVVVVVIPWIAIPVIPLGVIFFFLRRYFLETSRDVKRLECSTQSPVFSHLASSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLLLTITRWFSLHLDIIYLIFICLVDLGPCFFHKVTLNVGQLGLILSYALNVMVVFPWCIRLSVEVENMMISVERVIEYIELEQEAPWELEFRPPPDWPNNGMIALSNVNFKYSSDGPLVLKDLTTDIKPGEKVGIVGRTGAGKSSFIAALFRLSEPEGRVWIDKILITEIGLHDLRKKMSIIPQDPIVFTGTMRKNLDPFNKHTDEELWNVLEEVQLKEIIEELPDKMDTELVESGSNLSVGQKQLVCLARNILRKNQILIIDEATAHVDPSTDELIQKKIREKFAQCTVLTIAHRLSTIIDSDRIMVLDSGRLEEYDEPYVLLQNRDGLFYKMVQQLGKAKAAALTETAKQVSPLWGVVIKIYLHSSLLTIW", "length": 1312, "header": "tr|G5E5W7-1|G5E5W7_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC101906567 PE=3 SV=3 CANONICAL=A0AAA9SJG6-1" }, "locus": { "chromosome": "12", "start_pos": 70680712, "end_pos": 70341283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036965.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036965.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036813.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036813.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "ABC-type glutathione S-conjugate transporter activity", "id": "GO:0015431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1183, "end_pos": 1185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 760, "end_pos": 762, "annotation": "n_glycosylation_sequon" }, { "start_pos": 798, "end_pos": 800, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "66424", "name": "", "equation": "leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RZT1-1", "A0AAA9T569-1", "A0AAA9SJG6-1", "A0AAA9TUR1-1", "A0AAA9S3M4-1", "G3MW08-1", "A0AAA9TZ11-1", "A0A3Q1LXZ2-1", "A0AAA9T4S3-1", "A0A3Q1LPI1-1", "A0AAA9TR50-1", "A0A3Q1ML89-1", "A0AAA9SMB4-1" ], "evidence": [ { "id": "66424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66424" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LPI1", "gene_name": "LOC107131247", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] } ] }, { "uniprot_ac": "A0A3Q1LXZ2", "gene_name": "LOC521568", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] } ] }, { "uniprot_ac": "A0A3Q1ML89", "gene_name": "LOC100299180", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] } ] }, { "uniprot_ac": "A0AAA9RZT1", "gene_name": "LOC100337390", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] } ] }, { "uniprot_ac": "A0AAA9S3M4", "gene_name": "LOC100848700", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] } ] }, { "uniprot_ac": "A0AAA9SJG6", "gene_name": "LOC101906567", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] } ] }, { "uniprot_ac": "A0AAA9SMB4", "gene_name": "LOC100847574", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] } ] }, { "uniprot_ac": "A0AAA9T4S3", "gene_name": "LOC520016", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] } ] }, { "uniprot_ac": "A0AAA9T569", "gene_name": "ABCC4", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] } ] }, { "uniprot_ac": "A0AAA9TR50", "gene_name": "LOC509854", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] } ] }, { "uniprot_ac": "A0AAA9TUR1", "gene_name": "LOC528412", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] } ] }, { "uniprot_ac": "A0AAA9TZ11", "gene_name": "", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] } ] }, { "uniprot_ac": "G3MW08", "gene_name": "LOC100337076", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" }, { "id": "PS50929", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50929" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transmembrane type-1", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 357, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 410, "end_pos": 633, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.6.2.2", "ec_name": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "7.6.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2" }, { "id": "7.6.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.2" } ] }, { "ec_number": "7.6.2.3", "ec_name": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "7.6.2.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3" }, { "id": "7.6.2.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1183, "end_pos": 1185 }, { "start_pos": 752, "end_pos": 754 }, { "start_pos": 760, "end_pos": 762 }, { "start_pos": 798, "end_pos": 800 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMG7-1", "uniprot_ac": "A0AAA9SMG7", "uniprot_id": "A0AAA9SMG7_BOVIN", "mass": { "chemical_mass": 110198.0, "monoisotopic_mass": 110198.0 }, "refseq": { "ac": "NP_001179056", "name": "storkhead-box protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179056" }, "gene_names": [ { "name": "STOX1", "type": "recommended", "evidence": [ { "id": "A0AAA9SMG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ] }, { "name": "STOX1", "type": "synonym", "evidence": [ { "id": "NP_001179056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179056" } ] } ], "protein_names": [ { "name": "Storkhead box 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SMG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7/entry#names_and_taxonomy" } ] }, { "name": "storkhead-box protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179056" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STOX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7", "locus": { "chromosome": "28", "start_pos": 25172620, "end_pos": 25111884, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019028", "url": "https://www.ensembl.org/id/ENSBTAG00000019028" } ] } } ], "crossref": [ { "id": "A0AAA9SMG7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019028", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019028", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506979", "url": "https://www.ncbi.nlm.nih.gov/gene/506979", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506979", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506979", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PHTYFIT", "url": "https://omabrowser.org/oma/group/PHTYFIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8Y9", "url": "https://www.orthodb.org/?gene=E1B8Y9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22437", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22437", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22437:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22437:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10264", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10264", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179056", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Y9", "url": "https://www.uniprot.org/uniprotkb/E1B8Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Y9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQPVQLAPGSLALVLCRLQAQEEVEGAEEPGGRAVFRAFRRANARCFWNSRLARAASRLAFQGWLRRGVLLVHAPPASLQVLRDAWCRRALRPPRGFRILAVGDVFPVQMNPIAQSQFIPLAEVLCCAISDMNADQIVVTQESLLEHLMKRYPGIAIPSRDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTPQENKRVLSDENSQMPTSITYLVNVESCAELAKENAAFISHCHSCGCFHDVCTQDVQEPPAAVEVTNKGQKGLVESKSLVHNQAVSVSEENHVCESIKPLPHTKDREKVKKFGFNLFWRNISRKEKSRIEHSSFSAQFPPEEWPVRDEDNMDNIPRDIEHEIIKRINPILTVDNLIKHAVLMQKYEEQKKYNSQGTSTDMLTLRHKYFSKVGVKKRQGWSVKPRRQGHSHRDRHKARSQGSGPQPGNVRLEKHPKLPATQPTSSIKSPNEAVLQKPLGENPSALGPHLIYKKRISNPFQDLAPRGSPITKGHKIQKTSDLEPNQTGPKGKPFERSRSLVSSRIFESEAKELCGKQCNDILREESTYVNHSTVKSISDDFRDHLLNYSQCNVLQNGSKCCSFRESILRCDVYGGENEAIPEVSRRSYSHLDTLEETEEAQHVLPSGGSSLNQASPACRLVDSTVHQFQNLGLLDYPLGAKHLRQIERQDRDSKETLMGKAHVQEAQTVCLENEGLSDDDQALYQNEVEDEDGACSSLYLDEDDFSENDDLIQMLPDNIQFSFPEGNKWNHLGKQTVTERSLTEYDSNIQRFEPQVLKGNEHYKLTNPGESQKPNLSAENCILNLGIQCGFNYEEEPSVTECVQASAADDGSIFDYYSTGKATAEAEALQGSVGDTGKKPGSWSQSAQSQEMRKQFTHKLELFSTSHMSALAQDVQPERSHLEGAENQSLTGDSGIDSPRTQSLASNNSVILDGLKRRQNLLQNFEGTKSSQTLTSSSLLQLTPVINV", "length": 984, "header": "tr|A0AAA9SMG7-1|A0AAA9SMG7_BOVIN Isoform 1 of Storkhead box 1 OS=Bos taurus OX=9913 GN=STOX1 PE=4 SV=1 CANONICAL=A0AAA9SMG7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZ17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7/entry#A0AAA9RZ17-1", "sequence": { "sequence": "MNCSLPGFSVHRILQARILRFWFLLEYSLKNYLQGAALVFALFCDVFPVQMNPIAQSQFIPLAEVLCCAISDMNADQIVVTQESLLEHLMKRYPGIAIPSRDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTPQENKRVLSDENSQMPTSITYLVNVESCAELAKENAAFISHCHSCGCFHDVCTQDVQEPPAAVEVTNKGQKGLVESKSLVHNQAVSVSEENHVCESIKPLPHTKDREKVKKFGFNLFWRNISRKEKSRIEHSSFSAQFPPEEWPVRDEDNMDNIPRDIEHEIIKRINPILTVDNLIKHAVLMQKYEEQKKYNSQGTSTDMLTLRHKYFSKVGVKKRQGWSVKPRRQGHSHRDRHKARSQGSGPQPGNVRLEKHPKLPATQPTSSIKSPNEAVLQKPLGENPSALGPHLIYKKRISNPFQDLAPRGSPITKGHKIQKTSDLEPNQTGPKGKPFERSRSLVSSRIFESEAKELCGKQCNDILREESTYVNHSTVKSISDDFRDHLLNYSQCNVLQNGSKCCSFRESILRCDVYGGENEAIPEVSRRSYSHLDTLEETEEAQHVLPSGGSSLNQASPACRLVDSTVHQFQNLGLLDYPLGAKHLRQIERQDRDSKETLMGKAHVQEAQTVCLENEGLSDDDQALYQNEVEDEDGACSSLYLDEDDFSENDDLIQMLPDNIQFSFPEGNKWNHLGKQTVTERSLTEYDSNIQRFEPQVLKGNEHYKLTNPGESQKPNLSAENCILNLGIQCGFNYEEEPSVTECVQASAADDGSIFDYYSTGKATAEAEALQGSVGDTGKKPGSWSQSAQSQEMRKQFTHKLELFSTSHMSALAQDVQPERSHLEGAENQSLTGDSGIDSPRTQSLASNNSVILDGLKRRQNLLQNFEGTKSSQTLTSSSLLQLTPVINV", "length": 924, "header": "tr|A0AAA9RZ17-1|A0AAA9SMG7_BOVIN Computationally mapped isoform of Storkhead box 1 OS=Bos taurus OX=9913 GN=STOX1 PE=4 SV=1 CANONICAL=A0AAA9SMG7-1" }, "locus": { "chromosome": "28", "start_pos": 25171616, "end_pos": 25137972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119120.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119120.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075016.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075016.1" } ] } }, { "isoform_ac": "A0AAA9SMG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7/entry#A0AAA9SMG7-1", "sequence": { "sequence": "MAQPVQLAPGSLALVLCRLQAQEEVEGAEEPGGRAVFRAFRRANARCFWNSRLARAASRLAFQGWLRRGVLLVHAPPASLQVLRDAWCRRALRPPRGFRILAVGDVFPVQMNPIAQSQFIPLAEVLCCAISDMNADQIVVTQESLLEHLMKRYPGIAIPSRDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTPQENKRVLSDENSQMPTSITYLVNVESCAELAKENAAFISHCHSCGCFHDVCTQDVQEPPAAVEVTNKGQKGLVESKSLVHNQAVSVSEENHVCESIKPLPHTKDREKVKKFGFNLFWRNISRKEKSRIEHSSFSAQFPPEEWPVRDEDNMDNIPRDIEHEIIKRINPILTVDNLIKHAVLMQKYEEQKKYNSQGTSTDMLTLRHKYFSKVGVKKRQGWSVKPRRQGHSHRDRHKARSQGSGPQPGNVRLEKHPKLPATQPTSSIKSPNEAVLQKPLGENPSALGPHLIYKKRISNPFQDLAPRGSPITKGHKIQKTSDLEPNQTGPKGKPFERSRSLVSSRIFESEAKELCGKQCNDILREESTYVNHSTVKSISDDFRDHLLNYSQCNVLQNGSKCCSFRESILRCDVYGGENEAIPEVSRRSYSHLDTLEETEEAQHVLPSGGSSLNQASPACRLVDSTVHQFQNLGLLDYPLGAKHLRQIERQDRDSKETLMGKAHVQEAQTVCLENEGLSDDDQALYQNEVEDEDGACSSLYLDEDDFSENDDLIQMLPDNIQFSFPEGNKWNHLGKQTVTERSLTEYDSNIQRFEPQVLKGNEHYKLTNPGESQKPNLSAENCILNLGIQCGFNYEEEPSVTECVQASAADDGSIFDYYSTGKATAEAEALQGSVGDTGKKPGSWSQSAQSQEMRKQFTHKLELFSTSHMSALAQDVQPERSHLEGAENQSLTGDSGIDSPRTQSLASNNSVILDGLKRRQNLLQNFEGTKSSQTLTSSSLLQLTPVINV", "length": 984, "header": "tr|A0AAA9SMG7-1|A0AAA9SMG7_BOVIN Isoform 1 of Storkhead box 1 OS=Bos taurus OX=9913 GN=STOX1 PE=4 SV=1 CANONICAL=A0AAA9SMG7-1" }, "locus": { "chromosome": "28", "start_pos": 25171616, "end_pos": 25111937, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088912.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088912.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083952.1" } ] } }, { "isoform_ac": "E1B8Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7/entry#E1B8Y9-1", "sequence": { "sequence": "MRAPKLSCTSFRQHKWAGSLLGPLTSHQWIHLGTLHFSPDDSGQFSSQCSFKQSCFSCHQFICPCSVEDIWRCSAWKRLSGDVFPVQMNPIAQSQFIPLAEVLCCAISDMNADQIVVTQESLLEHLMKRYPGIAIPSRDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTPQENKRVLSDENSQMPTSITYLVNVESCAELAKENAAFISHCHSCGCFHDVCTQDVQEPPAAVEVTNKGQKGLVESKSLVHNQAVSVSEENHVCESIKPLPHTKDREKVKKFGFNLFWRNISRKEKSRIEHSSFSAQFPPEEWPVRDEDNMDNIPRDIEHEIIKRINPILTVDNLIKHAVLMQKYEEQKKYNSQGTSTDMLTLRHKYFSKVGVKKRQGWSVKPRRQGHSHRDRHKARSQGSGPQPGNVRLEKHPKLPATQPTSSIKSPNEAVLQKPLGENPSALGPHLIYKKRISNPFQDLAPRGSPITKGHKIQKTSDLEPNQTGPKGKPFERSRSLVSSRIFESEAKELCGKQCNDILREESTYVNHSTVKSISDDFRDHLLNYSQCNVLQNGSKCCSFRESILRCDVYGGENEAIPEVSRRSYSHLDTLEETEEAQHVLPSGGSSLNQASPACRLVDSTVHQFQNLGLLDYPLGAKHLRQIERQDRDSKETLMGKAHVQEAQTVCLENEGLSDDDQALYQNEVEDEDGACSSLYLDEDDFSENDDLIQMLPDNIQFSFPEGNKWNHLGKQTVTERSLTEYDSNIQRFEPQVLKGNEHYKLTNPGESQKPNLSAENCILNLGIQCGFNYEEEPSVTECVQASAADDGSIFDYYSTGKATAEAEALQGSVGDTGKKPGSWSQSAQSQEMRKQFTHKLELFSTSHMSALAQDVQPERSHLEGAENQSLTGDSGIDSPRTQSLASNNSVILDGLKRRQNLLQNFEGTKSSQTLTSSSLLQLTPVINV", "length": 961, "header": "tr|E1B8Y9-1|E1B8Y9_BOVIN Computationally mapped isoform of Storkhead box 1 OS=Bos taurus OX=9913 GN=STOX1 PE=4 SV=2 CANONICAL=A0AAA9SMG7-1" }, "locus": { "chromosome": "28", "start_pos": 25171616, "end_pos": 25147393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025324.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025324.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025324.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025324.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506979", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506979", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K418-1", "protein_name": "Storkhead box 1", "gene_name": "Stox1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARPVQLAPGSLALVLSPREAGQAAGEPGGRALFRAFRRANARCFWNARLARAASRLAFLGWLRRGVLLVRAPQPCVQVLRDAWRRRALRPPRGFRITAVGDVFPVQMSLIAQRRFVPLAEVLCCVIADMNAGQVAVTQEALLEHLMKHYPGIAVPSPDILYSTLGTLIQQRKIYHTGEGYFIVTPNTYFITNTTMQGNKRALLSDEGCSGSTSGTYLVSVDSCAEPTQENEVPVSHCPSCQCYPDTSKHGSKDLMTTAEVSRKRQNGLDKPTVLTKNQVVSASEDTHICVSPKPSSYTKDKGKRFGFGFLWRSLSRKEKPKAGYHSFSAQFPPEEWPVRDEDSSNNIPRDVEHAIIKRINPVLTVDNLTRHTALMQKYEEQKKHNSQGTSTDVLPSRHKYSSKEATRRRQGQAAKPHKRSCSHKGRQKAWSQTRELEPGSPEQEKEKNPKVPAAQPAASTKSPSERVHHLHGRNPAVLGSHLIYKKQINNPFQGMHLRGHPASKGYIVQKTHKPSCIGPEEKPFRRAGFSGPSRVFDGEAQPPCLEHCRDKLEAETTHVAKAPIHPVSDDFRGGPGNYPPHRVLTSHSRCCSFRESTLRAAVYHEENKVLPEVLRKSWSDCDMFLGTKEKKQVLPAQRSSLDPDSSVYAEDKTVDKTVHQFQNLGLLDCPVGANRLRTHERQDGDSEKLSRKAFQIPEAEIVNMEEEGLSDSEQDEVALSQSDPGAGDDGGCSSLCLEDDFSETDDFCHTLPGYTQYSFAAGNSWNHLGRPTMTGRSLTDCNSKTHRLEPLGIERNHWYKATGSFSNARESPNPDLADNPGLNSEIPPGFNYEGEPVVAHVQTPAAAGQSLLERSIVREASLPVEILQDSPGDRGENPAVWRQSLPSQEMKKHFTDKLQLVKTSHVPALAHLEGTENSSMAGDSGIDSPRTQSLVSTNSAMLDGFKRQNFLQTGESVQKSQKLASNSLLRLTPAINV", "length": 978 }, "evidence": [ { "id": "A0AAA9SMG7", "url": "https://omabrowser.org/oma/group/A0AAA9SMG7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B2RQL2-1", "protein_name": "Storkhead-box protein 1", "gene_name": "Stox1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARPVQLAPGSLALVLSPREAGQAAGEPGGRALFRAFRRANARCFWNARLARAASRLAFLGWLRRGVLLVRAPQPCVQVLRDAWRRRALRPPRGFRITAVGDVFPVQMSPIAQCRFVPLAEVLCCAIADMNAAQVMVTQQSLLEHLIKHYPGIAVPSPDILYSTLGALIQERKIYHTGEGYFIVTPSTYFITNTPMQGNKSALLSNEGCSGPTSGTYLVSVDCCAEPTQENEALFSHCPSCQCYPDTSMCDSKDLLTAAEVTRKSQEGLEETTALTENQVVSASEDTHICVNPKPLPYTKDKGKRFGFGFLWRSLSRKEKPKAEYHSFSAQFPPEEWPVRDEDSSTKIPRDVEHALIKRINPVLTVDNLTKHTALMQKYEEQKKYNSQGTSMDILTTRHKDSSKEVIGKRQGQFAKSRRRGSSHKGRHKARSQGSELEPGNPGQEKEKQPKVPAAQPAPRTKSPSEQVHHLQGRNPAVLGSHLIYKKQINNPFQGMHLRKHSVSKGHAVQKTHGLKPTCVGPEEKPFWSAGSSDPSGVFDGEAQPPYPEQCRDKLEAGSTQVAKAPVHPVSDDFRGGPGNYPPRRVLPGPSRCCSFRESMLRPGVYHEENKDLPEVLRKSWSTCDMFLGTKEKKQALPAQRCSLDPDSSSVHAEDKTVDKILHQFQNLGLLDCPAGANRLRTHERQDGNSEELSRKALQIPEAEIVNMENEGLSDSEQDQVALSHSDPGAGDDGGCSSLCLEDDDFSETDDFCPSLPGHTQHSFAGGGTWNHLGTPAMTGKSLTDCNSKAHRLELLAIERNPWYKATGLFSNAGESPNPDLSDNPGQNSRIPWGFNYEGEPTVAHVQTPAAAAGRSLLACSTVRTTSFPVEILQESPGDRGKSPIVWRQSLPSQEMKEHFTDKLQLVKTSHGPVSAQEPQGEHLEGTENYSMTGDSGIDSPRTQSLVSTNSAILDGFKRRQHFLPNREGVQKSQNLASNSLFQLTPAINV", "length": 990 }, "evidence": [ { "id": "A0AAA9SMG7", "url": "https://omabrowser.org/oma/group/A0AAA9SMG7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZVD7-1", "protein_name": "Storkhead-box protein 1", "gene_name": "STOX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARPVQLAPGSLALVLCRLEAQKAAGAAEEPGGRAVFRAFRRANARCFWNARLARAASRLAFQGWLRRGVLLVRAPPACLQVLRDAWRRRALRPPRGFRIRAVGDVFPVQMNPITQSQFVPLGEVLCCAISDMNTAQIVVTQESLLERLMKHYPGIAIPSEDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTTQENKRMLPSDESRLMPASMTYLVSMESCAESAQENAAPISHCQSCQCFRDMHTQDVQEAPVAAEVTRKSHRGLGESVSWVQNGAVSVSAEHHICESTKPLPYTRDKEKGKKFGFSLLWRSLSRKEKPKTEHSSFSAQFPPEEWPVRDEDDLDNIPRDVEHEIIKRINPILTVDNLIKHTVLMQKYEEQKKYNSQGTSTDMLTIGHKYPSKEGVKKRQGLSAKPQGQGHSRRDRHKARNQGSEFQPGSIRLEKHPKLPATQPIPRIKSPNEMVGQKPLGEITTVLGSHLIYKKRISNPFQGLSHRGSTISKGHKIQKTSDLKPSQTGPKEKPFQKPRSLDSSRIFDGKAKEPYAEQPNDKMEAESIYINDPTVKPINDDFRGHLFSHPQQSMLQNDGKCCPFMESMLRYEVYGGENEVIPEVLRKSHSHFDKLGETKQTPHSLPSRGASFSDRTPSACRLVDNTIHQFQNLGLLDYPVGVNPLRQAARQDKDSEELLRKGFVQDAETTSLENEQLSNDDQALYQNEVEDDDGACSSLYLEEDDISENDDLRQMLPGHSQYSFTGGSQGNHLGKQKVIERSLTEYNSTMERVESQVLKRNECYKPTGLHATPGESQEPNLSAESCGLNSGAQFGFNYEEEPSVAKCVQASAPADERIFDYYSARKASFEAEVIQDTIGDTGKKPASWSQSPQNQEMRKHFPQKFQLFNTSHMPVLAQDVQYEHSHLEGTENHSMAGDSGIDSPRTQSLGSNNSVILDGLKRRQNFLQNVEGTKSSQPLTSNSLLPLTPVINV", "length": 989 }, "evidence": [ { "id": "A0AAA9SMG7", "url": "https://omabrowser.org/oma/group/A0AAA9SMG7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "positive regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010971", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "regulation of mitochondrial membrane potential", "id": "GO:0051881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "inner ear development", "id": "GO:0048839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "regulation of mitochondrion organization", "id": "GO:0010821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010821", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "cellular response to nitrosative stress", "id": "GO:0071500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071500", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "regulation of mitochondrial DNA metabolic process", "id": "GO:1901858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901858", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "positive regulation of otic vesicle morphogenesis", "id": "GO:1904120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904120", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "regulation of response to oxidative stress", "id": "GO:1902882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" }, { "start_pos": 923, "end_pos": 925, "annotation": "n_glycosylation_sequon" }, { "start_pos": 943, "end_pos": 945, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG7" }, { "id": "PF10264", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10264" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Winged helix Storkhead-box1", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 189, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 592, "end_pos": 594 }, { "start_pos": 811, "end_pos": 813 }, { "start_pos": 923, "end_pos": 925 }, { "start_pos": 943, "end_pos": 945 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIL9-1", "uniprot_ac": "A0AAA9SIL9", "uniprot_id": "A0AAA9SIL9_BOVIN", "mass": { "chemical_mass": 17718.0, "monoisotopic_mass": 17718.0 }, "refseq": {}, "gene_names": [ { "name": "ANKRD40CL", "type": "recommended", "evidence": [ { "id": "A0AAA9SIL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9" } ] } ], "protein_names": [ { "name": "ANKRD40 C-terminal like", "type": "synonym", "evidence": [ { "id": "A0AAA9SIL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD40CL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9", "locus": { "chromosome": "19", "start_pos": 35987326, "end_pos": 35981207, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025183", "url": "https://www.ensembl.org/id/ENSBTAG00000025183" } ] } } ], "crossref": [ { "id": "A0AAA9SIL9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "512899", "url": "https://www.ncbi.nlm.nih.gov/gene/512899", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24192:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24192:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27687", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27687", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RZB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SPRATHFLQTFQTANKAHPTSHTQHRCIAKGTACHTLGFLDPGFTLPFELVLKVRIQSHKENDFIEVELDRQELSYQNLLQVSCYELGINPEQVEKIRKLPNTLLRKDKDILRLQDFQEVELILMKNGSSELAEYTPSLLEKPCYNSNAAKMTY", "length": 154, "header": "tr|A0AAA9SIL9-1|A0AAA9SIL9_BOVIN Isoform 1 of ANKRD40 C-terminal like OS=Bos taurus OX=9913 GN=ANKRD40CL PE=4 SV=1 CANONICAL=A0AAA9SIL9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9/entry#A0AAA9RZB4-1", "sequence": { "sequence": "MAEPQLDVKKPSELVLKVRIQSHKENDFIEVELDRQELSYQNLLQVSCYELGINPEQVEKIRKLPNTLLRKDKDILRLQDFQEVELILMKNGSSELAEYTPSLLEKPCYNSNAAKMTY", "length": 118, "header": "tr|A0AAA9RZB4-1|A0AAA9SIL9_BOVIN Computationally mapped isoform of ANKRD40 C-terminal like OS=Bos taurus OX=9913 GN=ANKRD40CL PE=4 SV=2 CANONICAL=A0AAA9SIL9-1" }, "locus": { "chromosome": "19", "start_pos": 35986555, "end_pos": 35981727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088092.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088092.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075131.2", "url": "https://www.ensembl.org/id/ENSBTAP00000075131.2" } ] } }, { "isoform_ac": "A0AAA9SIL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL9/entry#A0AAA9SIL9-1", "sequence": { "sequence": "SPRATHFLQTFQTANKAHPTSHTQHRCIAKGTACHTLGFLDPGFTLPFELVLKVRIQSHKENDFIEVELDRQELSYQNLLQVSCYELGINPEQVEKIRKLPNTLLRKDKDILRLQDFQEVELILMKNGSSELAEYTPSLLEKPCYNSNAAKMTY", "length": 154, "header": "tr|A0AAA9SIL9-1|A0AAA9SIL9_BOVIN Isoform 1 of ANKRD40 C-terminal like OS=Bos taurus OX=9913 GN=ANKRD40CL PE=4 SV=1 CANONICAL=A0AAA9SIL9-1" }, "locus": { "chromosome": "19", "start_pos": 35986555, "end_pos": 35985128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132136.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132136.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086094.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJI6-1", "uniprot_ac": "A0AAA9SJI6", "uniprot_id": "A0AAA9SJI6_BOVIN", "mass": { "chemical_mass": 99536.0, "monoisotopic_mass": 99536.0 }, "refseq": {}, "gene_names": [ { "name": "ZC3H12C", "type": "recommended", "evidence": [ { "id": "A0AAA9SJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ] } ], "protein_names": [ { "name": "Zinc finger CCCH-type containing 12C", "type": "synonym", "evidence": [ { "id": "A0AAA9SJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZC3H12C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6", "locus": { "chromosome": "15", "start_pos": 20240567, "end_pos": 20172827, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008732", "url": "https://www.ensembl.org/id/ENSBTAG00000008732" } ] } } ], "crossref": [ { "id": "A0AAA9SJI6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008732", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008732", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18729", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18729", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512586", "url": "https://www.ncbi.nlm.nih.gov/gene/512586", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040546", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040546", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512586", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512586", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RSPDCRY", "url": "https://omabrowser.org/oma/group/RSPDCRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MYD3", "url": "https://www.orthodb.org/?gene=F1MYD3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12876:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12876:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11977", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11977", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S133", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S133", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S133-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S133-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYD3", "url": "https://www.uniprot.org/uniprotkb/F1MYD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYD3-1", "url": "https://www.uniprot.org/uniprotkb/F1MYD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLYFPVNEYGVLCIQEYRKNSKVESSTHNSFMGLKDHLGHDPGHLYVESADPHLSTSVPWSMVEKPTMDKVNSGKEEKEVSEENASSGDSEESTNSDNESEQLSSISVEPCLLTKTHRQLCRSPCLEPHILKCSEILQDFKPEESQPSKEMKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEAEQTVSTLNIIMRETSSLESQRSESPMQEIITDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAVKTANEGGLVKSNSVPCNTKGDSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRISSVASDCSSEGSLSCGSSDSYVGYNDRTYVSSPDPQLEENLKCPHMHPHGRLNSQPFLQSFHDPLTRVQSYSHEEPKYHHKPPLPHPAVRLQHPAVGARSSCPGDYPSPPGSAHAKAPHLGRSLVATRIDSISDSRLYDGSPSRPRKPHARQEGLGGWDRQSYGLDAYGYRQTYSLPDNPTQPCYEQFTFQSLPEQPEPTWRVPYCGAPPPDPPRYQDSREKVFVNLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 884, "header": "tr|A0AAA9SJI6-1|A0AAA9SJI6_BOVIN Isoform 1 of Zinc finger CCCH-type containing 12C OS=Bos taurus OX=9913 GN=ZC3H12C PE=3 SV=1 CANONICAL=A0AAA9SJI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S133-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6/entry#A0AAA9S133-1", "sequence": { "sequence": "MADEERLQEYGVLCIQEYRKNSKVESSTHNSFMGLKDHLGHDPGHLYVESADPHLSTSVPWSMVEKPTMDKVNSGKEEKEVSEENASSGDSEESTNSDNESEQLSSISVEPCLLTKTHRQLCRSPCLEPHILKCSEILQDFKPEESQPSKEMKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEAEQTVSTLNIIMRETSSLESQRSESPMQEIITDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAVKTANEGGLVKSNSVPCNTKGDSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRISSVASDCSSEGSLSCGSSDSYVGYNDRTYVSSPDPQLEENLKCPHMHPHGRLNSQPFLQSFHDPLTRVQSYSHEEPKYHHKPPLPHPAVRLQHPAVGARSSCPGDYPSPPGSAHAKAPHLGRSLVATRIDSISDSRLYDGSPSRPRKPHARQEGLGGWDRQSYGLDAYGYRQTYSLPDNPTQPCYEQFTFQSLPEQPEPTWRVPYCGAPPPDPPRYQDSREKVFVNLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 884, "header": "tr|A0AAA9S133-1|A0AAA9SJI6_BOVIN Computationally mapped isoform of Zinc finger CCCH-type containing 12C OS=Bos taurus OX=9913 GN=ZC3H12C PE=3 SV=1 CANONICAL=A0AAA9SJI6-1" }, "locus": { "chromosome": "15", "start_pos": 20239563, "end_pos": 20173026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110294.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110294.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079580.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079580.1" } ] } }, { "isoform_ac": "A0AAA9SJI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6/entry#A0AAA9SJI6-1", "sequence": { "sequence": "MSLYFPVNEYGVLCIQEYRKNSKVESSTHNSFMGLKDHLGHDPGHLYVESADPHLSTSVPWSMVEKPTMDKVNSGKEEKEVSEENASSGDSEESTNSDNESEQLSSISVEPCLLTKTHRQLCRSPCLEPHILKCSEILQDFKPEESQPSKEMKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEAEQTVSTLNIIMRETSSLESQRSESPMQEIITDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAVKTANEGGLVKSNSVPCNTKGDSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRISSVASDCSSEGSLSCGSSDSYVGYNDRTYVSSPDPQLEENLKCPHMHPHGRLNSQPFLQSFHDPLTRVQSYSHEEPKYHHKPPLPHPAVRLQHPAVGARSSCPGDYPSPPGSAHAKAPHLGRSLVATRIDSISDSRLYDGSPSRPRKPHARQEGLGGWDRQSYGLDAYGYRQTYSLPDNPTQPCYEQFTFQSLPEQPEPTWRVPYCGAPPPDPPRYQDSREKVFVNLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 884, "header": "tr|A0AAA9SJI6-1|A0AAA9SJI6_BOVIN Isoform 1 of Zinc finger CCCH-type containing 12C OS=Bos taurus OX=9913 GN=ZC3H12C PE=3 SV=1 CANONICAL=A0AAA9SJI6-1" }, "locus": { "chromosome": "15", "start_pos": 20239563, "end_pos": 20202356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105006.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105006.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083971.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083971.1" } ] } }, { "isoform_ac": "A0AAA9TL41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6/entry#A0AAA9TL41-1", "sequence": { "sequence": "MPGSGPQEYGVLCIQEYRKNSKVESSTHNSFMGLKDHLGHDPGHLYVESADPHLSTSVPWSMVEKPTMDKVNSGKEEKEVSEENASSGDSEESTNSDNESEQLSSISVEPCLLTKTHRQLCRSPCLEPHILKCSEILQDFKPEESQPSKEMKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEAEQTVSTLNIIMRETSSLESQRSESPMQEIITDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAVKTANEGGLVKSNSVPCNTKGDSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRISSVASDCSSEGSLSCGSSDSYVGYNDRTYVSSPDPQLEENLKCPHMHPHGRLNSQPFLQSFHDPLTRVQSYSHEEPKYHHKPPLPHPAVRLQHPAVGARSSCPGDYPSPPGSAHAKAPHLGRSLVATRIDSISDSRLYDGSPSRPRKPHARQEGLGGWDRQSYGLDAYGYRQTYSLPDNPTQPCYEQFTFQSLPEQPEPTWRVPYCGAPPPDPPRYQDSREKVFVNLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 883, "header": "tr|A0AAA9TL41-1|A0AAA9TL41_BOVIN Computationally mapped isoform of Zinc finger CCCH-type containing 12C OS=Bos taurus OX=9913 GN=ZC3H12C PE=3 SV=2 CANONICAL=A0AAA9SJI6-1" }, "locus": { "chromosome": "15", "start_pos": 20239563, "end_pos": 20173226, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105040.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105040.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097004.1" } ] } }, { "isoform_ac": "A0AAA9TU25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6/entry#A0AAA9TU25-1", "sequence": { "sequence": "MGLKDHLGHDPGHLYVESADPHLSTSVPWSMVEKPTMDKVNSGKEEKEVSEENASSGDSEESTNSDNESEQLSSISVEPCLLTKTHRQLCRSPCLEPHILKCSEILQDFKPEESQPSKEMKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEAEQTVSTLNIIMRETSSLESQRSESPMQEIITDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAVKTANEGGLVKSNSVPCNTKGDSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRISSVASDCSSEGSLSCGSSDSYVGYNDRTYVSSPDPQLEENLKCPHMHPHGRLNSQPFLQSFHDPLTRVQSYSHEEPKYHHKPPLPHPAVRLQHPAVGARSSCPGDYPSPPGSAHAKAPHLGRSLVATRIDSISDSRLYDGSPSRPRKPHARQEGLGGWDRQSYGLDAYGYRQTYSLPDNPTQPCYEQFTFQSLPEQPEPTWRVPYCGAPPPDPPRYQDSREKVFVNLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 852, "header": "tr|A0AAA9TU25-1|A0AAA9TU25_BOVIN Computationally mapped isoform of Zinc finger CCCH-type containing 12C OS=Bos taurus OX=9913 GN=ZC3H12C PE=3 SV=1 CANONICAL=A0AAA9SJI6-1" }, "locus": { "chromosome": "15", "start_pos": 20239563, "end_pos": 20207649, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100048.1" } ] } }, { "isoform_ac": "F1MYD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6/entry#F1MYD3-1", "sequence": { "sequence": "MDCSPPGFSVHGIFQEYGVLCIQEYRKNSKVESSTHNSFMGLKDHLGHDPGHLYVESADPHLSTSVPWSMVEKPTMDKVNSGKEEKEVSEENASSGDSEESTNSDNESEQLSSISVEPCLLTKTHRQLCRSPCLEPHILKCSEILQDFKPEESQPSKEMKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEAEQTVSTLNIIMRETSSLESQRSESPMQEIITDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAVKTANEGGLVKSNSVPCNTKGDSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSISGPRSPERRFSLDTDYRISSVASDCSSEGSLSCGSSDSYVGYNDRTYVSSPDPQLEENLKCPHMHPHGRLNSQPFLQSFHDPLTRVQSYSHEEPKYHHKPPLPHPAVRLQHPAVGARSSCPGDYPSPPGSAHAKAPHLGRSLVATRIDSISDSRLYDGSPSRPRKPHARQEGLGGWDRQSYGLDAYGYRQTYSLPDNPTQPCYEQFTFQSLPEQPEPTWRVPYCGAPPPDPPRYQDSREKVFVNLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 891, "header": "tr|F1MYD3-1|F1MYD3_BOVIN Computationally mapped isoform of Zinc finger CCCH-type containing 12C OS=Bos taurus OX=9913 GN=ZC3H12C PE=3 SV=4 CANONICAL=A0AAA9SJI6-1" }, "locus": { "chromosome": "15", "start_pos": 20239563, "end_pos": 20183128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011504.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011504.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011504.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011504.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512586", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512586", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5XWR9-1", "protein_name": "Zinc finger CCCH type containing 12C", "gene_name": "Zc3h12c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAGPGAAEGNGPTAVILPLGPSRARGEYGVLCIQEYRKSSKVESSARNSFMGLKDHLGHDLGHLYMESADPQISAAVPWPMAEKPTMDTVSAGKEEKGVSEENVSSGDSEESTNSDHESEQLSSLSVEPCLLTKTHRQLCRSPCLEPHLLKHSDVLQDFKPEESQTPSKEVKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTVNSAMRETSSLESQRSESPMPEIVTDDGENLRPVVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTTNEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTHVYQDIEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGAPMPYEQYPKCESPVDVGYYSMLNAYSNLSISGPRSPERRFSLDTDYRVNSVASDCSSEGSMSCGSSDSYVGYSDRSYVSSPDPQLEENLKGQHMHPHSRLNSQPFLQSFHDPLTRVQSYSHEEPKFHHKRPLPHLAMHLQHPAVGARSSCPGDYPSPPSSAHSKASHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWDRPSYGMDAYGYRQTYSLPDNSTPPCYESITFQSLPEQQEPTWRIPYCGMPHDPPRYQDSREKIYINLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 903 }, "evidence": [ { "id": "A0AAA9SJI6", "url": "https://omabrowser.org/oma/group/A0AAA9SJI6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5DTV4-1", "protein_name": "Probable ribonuclease ZC3H12C", "gene_name": "Zc3h12c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAEKTLQEYGVLCIQEYRKSSKVESSARNSFMGLKDHLGHDLGHLYMESTDPQMSAAVPWPMVEKPTMDTVNSGKEGKGVSEENVSSGDSEGSTSSDHESEQLSSLSVEPCSLTKTHRQLCRSPCLEPRLLKHSDILQDFKPEESQTPSKEVKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINSVMRETSSLESQRSESPMQEVVVDDGENLRPVVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTTNEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTHVYQDIEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTPLSNGLPSGVHFPPQDQRPQGQYPPMMMATKNHGTPMPYEQYPKCDSPVDVGYYSMLNAYSNLSISGPRSPERRFSLDTDYRVNSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEESLKCQHMHPHSRLNSQPFLQNFHDPLTRVQSYSHEEPKFHPKRPLPHLAMHLQHPAVGARSSCPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWGRPSYGLEAYGYRQTYSLPDNSTPPCYESITFQSLPEQQEPTWRIPYCGMPHDPPRYQDNREKIFINLCNIFPPDLVRLVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 884 }, "evidence": [ { "id": "A0AAA9SJI6", "url": "https://omabrowser.org/oma/group/A0AAA9SJI6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C0D7-1", "protein_name": "Probable ribonuclease ZC3H12C", "gene_name": "ZC3H12C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGGGSQEYGVLCIQEYRKNSKVESSTRNNFMGLKDHLGHDLGHLYVESTDPQLSPAVPWSTVENPSMDTVNVGKDEKEASEENASSGDSEENTNSDHESEQLGSISVEPGLITKTHRQLCRSPCLEPHILKRNEILQDFKPEESQTTSKEAKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINTITRETSSLESQRSESPMQEIVTDDGENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHKKQPCPYGKKCTYGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTANEGGLVKSNSVPCSTKADSTSDVKRGAPKRQSDPSIRTQVYQDLEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQYPSMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSLSGPRSPERRFSLDTDYRISSVASDCSSEGSMSCGSSDSYVGYNDRSYVSSPDPQLEENLKCQHMHPHSRLNPQPFLQNFHDPLTRGQSYSHEEPKFHHKPPLPHLALHLPHSAVGARSSCPGDYPSPPSSAHSKAPHLGRSLVATRIDSISDSRLYDSSPSRQRKPYSRQEGLGSWERPGYGIDAYGYRQTYSLPDNSTQPCYEQFTFQSLPEQQEPAWRIPYCGMPQDPPRYQDNREKIYINLCNIFPPDLVRIVMKRNPHMTDAQQLAAAILVEKSQLGY", "length": 883 }, "evidence": [ { "id": "A0AAA9SJI6", "url": "https://omabrowser.org/oma/group/A0AAA9SJI6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "3'-UTR-mediated mRNA destabilization", "id": "GO:0061158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJI6" }, { "id": "PS50103", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50103" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C3H1-type", "eco_id": "ECO_0000259", "start_pos": 410, "end_pos": 435, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 85, "end_pos": 87 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIF9-1", "uniprot_ac": "A0AAA9SIF9", "uniprot_id": "A0AAA9SIF9_BOVIN", "mass": { "chemical_mass": 94322.0, "monoisotopic_mass": 94322.0 }, "refseq": { "ac": "NP_001179540", "name": "BEN domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179540" }, "gene_names": [ { "name": "BEND3", "type": "recommended", "evidence": [ { "id": "A0AAA9SIF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ] }, { "name": "BEND3", "type": "synonym", "evidence": [ { "id": "NP_001179540", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179540" } ] } ], "protein_names": [ { "name": "BEN domain containing 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SIF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#names_and_taxonomy" } ] }, { "name": "BEN domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001179540", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179540" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BEND3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9", "locus": { "chromosome": "9", "start_pos": 42927604, "end_pos": 42875558, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012534", "url": "https://www.ensembl.org/id/ENSBTAG00000012534" } ] } } ], "crossref": [ { "id": "A0AAA9SIF9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012534", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012534", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525371", "url": "https://www.ncbi.nlm.nih.gov/gene/525371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525371", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525371", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AEHPQTY", "url": "https://omabrowser.org/oma/group/AEHPQTY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BHG2", "url": "https://www.orthodb.org/?gene=E1BHG2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28665", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28665", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28665:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28665:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10523", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10523", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179540", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2F4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2F4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHG2", "url": "https://www.uniprot.org/uniprotkb/E1BHG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHG2-1", "url": "https://www.uniprot.org/uniprotkb/E1BHG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSAEKHPLDGVFTAVQDSSKRKPLGGEGPLDSVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 829, "header": "tr|A0AAA9SIF9-1|A0AAA9SIF9_BOVIN Isoform 1 of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=1 CANONICAL=A0AAA9SIF9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2F4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#A0AAA9S2F4-1", "sequence": { "sequence": "MNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSAEKHPLDGVFTAVQDSSKRKPLGGEGPLDSVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKKVLLSYIWPVPRPQDETPLFSSLVGKVTLLQASGMLSRIPTRKLPNR", "length": 873, "header": "tr|A0AAA9S2F4-1|A0AAA9SIF9_BOVIN Computationally mapped isoform of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=1 CANONICAL=A0AAA9SIF9-1" }, "locus": { "chromosome": "9", "start_pos": 42926600, "end_pos": 42910877, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091158.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091158.1" } ] } }, { "isoform_ac": "A0AAA9SIF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#A0AAA9SIF9-1", "sequence": { "sequence": "MNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSAEKHPLDGVFTAVQDSSKRKPLGGEGPLDSVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 829, "header": "tr|A0AAA9SIF9-1|A0AAA9SIF9_BOVIN Isoform 1 of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=1 CANONICAL=A0AAA9SIF9-1" }, "locus": { "chromosome": "9", "start_pos": 42924966, "end_pos": 42910877, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132366.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132366.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083531.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083531.1" } ] } }, { "isoform_ac": "A0AAA9SLN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#A0AAA9SLN2-1", "sequence": { "sequence": "MWEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 752, "header": "tr|A0AAA9SLN2-1|A0AAA9SLN2_BOVIN Computationally mapped isoform of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=1 CANONICAL=A0AAA9SIF9-1" }, "locus": { "chromosome": "9", "start_pos": 42924966, "end_pos": 42914755, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104058.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104058.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086160.1" } ] } }, { "isoform_ac": "A0AAA9TFW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#A0AAA9TFW7-1", "sequence": { "sequence": "MKRWTRTVEQKMNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSAEKHPLDGVFTAVQDSSKRKPLGGEGPLDSVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 840, "header": "tr|A0AAA9TFW7-1|A0AAA9TFW7_BOVIN Computationally mapped isoform of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=1 CANONICAL=A0AAA9SIF9-1" }, "locus": { "chromosome": "9", "start_pos": 42924966, "end_pos": 42875757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100213.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100213.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095915.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095915.1" } ] } }, { "isoform_ac": "A0AAA9TWN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#A0AAA9TWN3-1", "sequence": { "sequence": "MCGRGLCASASETFKFTFLTRCTLSAQEAATPASHLTREAAQPPPALLPPAGGSVEQKMNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSAEKHPLDGVFTAVQDSSKRKPLGGEGPLDSVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 887, "header": "tr|A0AAA9TWN3-1|A0AAA9TWN3_BOVIN Computationally mapped isoform of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=1 CANONICAL=A0AAA9SIF9-1" }, "locus": { "chromosome": "9", "start_pos": 42924966, "end_pos": 42897001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102417.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102417.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103064.1" } ] } }, { "isoform_ac": "E1BHG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9/entry#E1BHG2-1", "sequence": { "sequence": "MSALGRPGPRSARPSSLPRPFTPERRRRSRVCPAEGEGRAGGGGGGVVVPLQRGLLCPCAEMTHGVPSRHARAQRTDTHKERGKYTAPARCPQQLPGPPRPGPPRAAPTPQPRAPPTPHVAPQLGAGPLCKVQNSCPSRCTLSAQEAATPASHLTREAAQPPPALLPPAGGSVEQKMNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSAEKHPLDGVFTAVQDSSKRKPLGGEGPLDSVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEPAGRGKNLGSMWPGEEEPGHDVSTPSYKKPLYGISHKIMEKKNPPAGDMLNTYELSEKVNPSNSPSPLRLLNETQKRDTGGPAAATDSDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCGACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVSGFFEAEPQVDAGHFLDSKEQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEDAWLQQCAQRINDELEGLGLDAGSEGEPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 1005, "header": "tr|E1BHG2-1|E1BHG2_BOVIN Computationally mapped isoform of BEN domain containing 3 OS=Bos taurus OX=9913 GN=BEND3 PE=4 SV=2 CANONICAL=A0AAA9SIF9-1" }, "locus": { "chromosome": "9", "start_pos": 42924966, "end_pos": 42895555, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016639.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016639.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016639.4", "url": "https://www.ensembl.org/id/ENSBTAP00000016639.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525371", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525371", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B0B0-1", "protein_name": "BEN domain containing 3", "gene_name": "BEND3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNATEFSEDVEEVLKNNTVKVETEAEDAALDCSVNSRSSEKHPLDGVFTALQDSSKRKQPSGSGGGDGPPDPVPSVKRRRLIPEALLAGMRNRENSSPCQGNGEQAGRGRNSGSVWPGEEEPGNDVTTPSYKKPLYGISHKIMEKKNPPPGDVLNTYELFEKANPSNSPSPLRLLNEPQKRDCGGGAAATDGDPNIYFLIQKMFYMLNTLSSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVAGFFEADQVDSGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGRQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLDAGSEGEAARDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTAENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 832 }, "evidence": [ { "id": "A0AAA9SIF9", "url": "https://omabrowser.org/oma/group/A0AAA9SIF9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y9R1-1", "protein_name": "BEN domain containing 3", "gene_name": "BEND3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNSAEITDDDEVKIPKKNIVKVETENEDEALDCSVTSRSSEKHSVDGAVTCLQDSNKRKQTSLGCDGSGSQQDVLPSVKKRRFTQEGSNSNMKNRDTGSPTQANSEQPSKNKNPNITWLCEEEPFSDITTSSYKKPLYGISHKITEKKNAPGAEQFASYDLYEKISPSSPSHLRTLNDQRKRDSAAALAAAAVAVESDPNIYSLIQKMFFTLNTLSSNMTQLHNKVDLLSLEVSRIKKQVSPVECVADFKPPPEYTLTSAELKQLMDQSTSGGDLACRLLVQLFPELFSDDEFNRNCSACGFPNKRKLESLHLQLIRSYVEVCYPSVKSTAVWQVECLPQLNDFFNRFWAQRELENNPQNVQSSSFYETEQVDSSHFLEDKEQEEALSLDRSNAIASDYILDAQDLNEFLDEASSPGEFCVFLLHRLFPELFDHRKLAERYSCYGDSGKQLLDPHRLQIIRRYTEIYFPDVQEEEAWLQQCVQRINEELENVYMDGSECDQLRDDCYDSSSLPDDVSIIKVEDSFEYEKPGRRSKKIWLVPIDFDKLDFPPPDFDVPVPDYLLNKEQIKNIYESSLSIGNFASRLLVLLFPELFTHENLRKQYNCSGSLGKKQLDPTRIKLIRHYVQILYPRAKNDRVWMLEFVGKLDERCRRRDTEQRRSYQQQRKVHMPGPERREFLSYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVIPNPDFPVPSPYLLTDKEVREIVQQSLSVGNFAARLLVRLFPELFTPENLRLQYNHSGACNKKQLDPIRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKAKK", "length": 836 }, "evidence": [ { "id": "A0AAA9SIF9", "url": "https://omabrowser.org/oma/group/A0AAA9SIF9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B7ZD94-1", "protein_name": "BEN domain-containing protein 3", "gene_name": "bend3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSSLCMVNADGQVPDKKVKVEKDAEDVIENTEGKMESFFKSITKRASTGSDVERPNSGKRIKVTTPAGENLLDSSSDDGSRSCSYVHRSSPEQISISSYRKPLYSITHRISERKAASSLDQSEAHNGVRASQNGVHFQKLGNSRKHHMFKASPTVGVTGSPASLDSHLYPLIEKMFFLLNTLNSSMTQLHSKVDLLSLEVTRIKKQMKPSEMVMEFQPPPEYQLTSEELAQLMEQTSTAGELGCRLLVQLFPELFTTKECAHGCSTCSLTSKRTLDSLHLQLIRNYVEACYPLVKNENVWQTECLLQINDFLNRYWAQKDMESGQVCDKQAPMVVGFDIEPNHTCHFISEDAQDETLSLNSGENNDVHSNNVSSDVVLDSHEAAGDDSEDLTSPEELVIFLLNRLFPEVFEEGKLPEGHNSIGQLITDSDRLEILRKYMEANFPDIPEDTWLQLCVQRMEEALENASTSGNGEMYNTTRLPDNISIVKISDLCDYEKPNRRSKKSWLEPMDFDKLEIPLPNFDVPQEYLLTKEQLKNNYECSLSIGNFASRLLVLMFPELFTNENARKYYNCSGSLGKKQLDPLRISLIRHYVQLLYPQAKNDRVWTLEFVGKLDERCRRRDTDQRRSYQQQRKACSPDQEPDPNDSLLSAGQINALTSDRLKEDFEVLSSPLEKSSKDFCKIPLEDLSVPTPDFPVPSEYLLTDAEVREIVQQSLSVGNFAARLLVRLFPELFTQENLRLQYNHSGACNKKQLDPMRLRLIRHYVEAVYPVDKMEEVWHYECVPSIDERCRRPNRKKCDILKKAKRSNNTVTYS", "length": 816 }, "evidence": [ { "id": "A0AAA9SIF9", "url": "https://omabrowser.org/oma/group/A0AAA9SIF9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "M0RCL1-1", "protein_name": "BEN domain containing 3", "gene_name": "Bend3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSTEFSEDVEEVLKTNPVKVEGGDAAALDCSRNSRASEKHPLDSVLTALHNSSKRKQLGSDGQADSVPGEKRRRLISEALVAGMRNRENSSPCQGNGEPATRGRGGSCVWPAEEEPSTEATAPSYKKPLYGISHKIMEKKNPPSGDLLSPYELFEKANSSNSPSPLRLLNESQKRECGVGAATDGDSSIYFLIQKMFYTLNTLTSNMSQLHSKMDLLSLEVGRIKKQVSSSELVAKFQPPPEYQLTAAELKQIAEQSLSCGDLACRLLVQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPSVKDSAVWQAECLPQLNDFFSRFWAQREMEDSQPGGQVTNFFEADQVDAGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLEGGSEGEAPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEMPGSDCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPARIRLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTAENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 826 }, "evidence": [ { "id": "A0AAA9SIF9", "url": "https://omabrowser.org/oma/group/A0AAA9SIF9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T5X7-1", "protein_name": "BEN domain-containing protein 3", "gene_name": "BEND3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSTEFTEDVEEVLKSITVKVETEAEDAALDCSVNSRTSEKHSVDSVLTALQDSSKRKQLVSDGLLDSVPGVKRRRLIPEALLAGMRNRENSSPCQGNGEQAGRGRSLGNVWPGEEEPCNDATTPSYKKPLYGISHKIMEKKNPPSGDLLNVYELFEKANASNSPSSLRLLNEPQKRDCGSTGAGTDNDPNIYFLIQKMFYMLNTLTSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVASFFEAEQVDPGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLDAGSEGDPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLTSYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTAENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 828 }, "evidence": [ { "id": "A0AAA9SIF9", "url": "https://omabrowser.org/oma/group/A0AAA9SIF9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PAL0-1", "protein_name": "BEN domain-containing protein 3", "gene_name": "Bend3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSTEISEDVEEVLKNNPVKAEGSDATLDCSRNSRASEKHLLESVLTALHDSSKRKQLDSDGQPDSVPSVKRRRLIPEALLAGMRTRENSSPCQGNGEPASRGRSGSCAWPAEEEPSTEATVPSYKKPLYGISHKIMEKKNPPSGDLLSPYELFEKANSSSGPSPLRLLSESQKRECGVGVATDGDLNIYFLIQKMFYMLNGLTTNMSQLHSKMDLLSLEVSRVKKQVSPSELVAKFQPPPEYQLTASELKQIAEQSLSCGDLACRLLLQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPNVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPGGQVTNFFEADQVDAGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLEGGSEGEAPRDDCYDSSSLPDDISVVKVEDNFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEMPGSDCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPARIRLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK", "length": 825 }, "evidence": [ { "id": "A0AAA9SIF9", "url": "https://omabrowser.org/oma/group/A0AAA9SIF9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" }, { "name": "rDNA binding", "id": "GO:0000182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000182", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "rDNA heterochromatin formation", "id": "GO:0000183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000183", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" }, { "name": "DNA methylation-dependent constitutive heterochromatin formation", "id": "GO:0006346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006346", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" }, { "name": "positive regulation of ATP metabolic process", "id": "GO:1903580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903580", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF9" }, { "id": "PS51457", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51457" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BEN", "eco_id": "ECO_0000259", "start_pos": 242, "end_pos": 343, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 172, "end_pos": 174 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 454, "end_pos": 456 }, { "start_pos": 597, "end_pos": 599 }, { "start_pos": 763, "end_pos": 765 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMA3-1", "uniprot_ac": "A0AAA9SMA3", "uniprot_id": "A0AAA9SMA3_BOVIN", "mass": { "chemical_mass": 31464.0, "monoisotopic_mass": 31464.0 }, "refseq": {}, "gene_names": [ { "name": "TMIGD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ] } ], "protein_names": [ { "name": "Transmembrane and immunoglobulin domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2G8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G8#function" }, { "database": "UniProtKB", "id": "ARBA00059449", "url": "https://www.uniprot.org/uniprotkb/ARBA00059449#function" }, { "database": "UniProtKB", "id": "F1MLX4", "url": "https://www.uniprot.org/uniprotkb/F1MLX4#function" }, { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3#function" }, { "database": "UniProtKB", "id": "A0AAA9TXB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXB5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMIGD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3", "locus": { "chromosome": "19", "start_pos": 21399082, "end_pos": 21413846, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002609", "url": "https://www.ensembl.org/id/ENSBTAG00000002609" } ] } } ], "crossref": [ { "id": "A0AAA9SMA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002609", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002609", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLX4", "url": "https://www.orthodb.org/?gene=F1MLX4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11640:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11640:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S2G8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLX4", "url": "https://www.uniprot.org/uniprotkb/F1MLX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLX4-1", "url": "https://www.uniprot.org/uniprotkb/F1MLX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILCSRAYLRRKSDVNSLKMAQKTSGLIQRCRFLLLMILFLPHVMTSSVLSVNGKTENYILDTEPGLQESLKCAVQNHIRDEELLWYREDGRVDLKSGNKINSSSVCVSGISEDDNGITFTCKLQRNQSVSISVVLNVTFPPLLSGNDFQTAEEGSDVKLVCNVKSNPQAQMMWYKNNGILNLENHHQIQQTSKYFQLSITKVKKSDNGTYSCIANSLIETKTKDFHLIVKDKGSTVPIEPIIAACVVVFLTLVFGVIARRKRIMKLCRKDQGPQCRTAL", "length": 280, "header": "tr|A0AAA9SMA3-1|A0AAA9SMA3_BOVIN Isoform 1 of Transmembrane and immunoglobulin domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMIGD1 PE=4 SV=1 CANONICAL=A0AAA9SMA3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3/entry#A0AAA9S2G8-1", "sequence": { "sequence": "MAQKTSGLIQRCRFLLLMILFLPHVMTSSVLSVNGKTENYILDTEPGLQESLKCAVQNHIRDEELLWYREDGRVDLKSGNKINSSSVCVSGISEDDNGITFTCKLQRNQSVSISVVLNVTFPPLLSGNDFQTAEEGSDVKLVCNVKSNPQAQMMWYKNNGILNLENHHQIQQTSKYFQLSITKVKKSDNGTYSCIANSLIETKTKDFHLIVKALQKGS", "length": 218, "header": "tr|A0AAA9S2G8-1|A0AAA9SMA3_BOVIN Computationally mapped isoform of Transmembrane and immunoglobulin domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMIGD1 PE=4 SV=1 CANONICAL=A0AAA9SMA3-1" }, "locus": { "chromosome": "19", "start_pos": 21412827, "end_pos": 21400068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098007.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098007.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077907.1" } ] } }, { "isoform_ac": "A0AAA9SMA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3/entry#A0AAA9SMA3-1", "sequence": { "sequence": "MILCSRAYLRRKSDVNSLKMAQKTSGLIQRCRFLLLMILFLPHVMTSSVLSVNGKTENYILDTEPGLQESLKCAVQNHIRDEELLWYREDGRVDLKSGNKINSSSVCVSGISEDDNGITFTCKLQRNQSVSISVVLNVTFPPLLSGNDFQTAEEGSDVKLVCNVKSNPQAQMMWYKNNGILNLENHHQIQQTSKYFQLSITKVKKSDNGTYSCIANSLIETKTKDFHLIVKDKGSTVPIEPIIAACVVVFLTLVFGVIARRKRIMKLCRKDQGPQCRTAL", "length": 280, "header": "tr|A0AAA9SMA3-1|A0AAA9SMA3_BOVIN Isoform 1 of Transmembrane and immunoglobulin domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMIGD1 PE=4 SV=1 CANONICAL=A0AAA9SMA3-1" }, "locus": { "chromosome": "19", "start_pos": 21413517, "end_pos": 21399197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131084.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131084.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087497.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087497.1" } ] } }, { "isoform_ac": "A0AAA9TXB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3/entry#A0AAA9TXB5-1", "sequence": { "sequence": "MDCMLHGVAKSSVLSVNGKTENYILDTEPGLQESLKCAVQNHIRDEELLWYREDGRVDLKSGNKINSSSVCVSGISEDDNGITFTCKLQRNQSVSISVVLNVTFPPLLSGNDFQTAEEGSDVKLVCNVKSNPQAQMMWYKNNGILNLENHHQIQQTSKYFQLSITKVKKSDNGTYSCIANSLIETKTKDFHLIVKDKGSTVPIEPIIAACVVVFLTLVFGVIARRKRIMKLCRKDQGPQCRTAL", "length": 244, "header": "tr|A0AAA9TXB5-1|A0AAA9TXB5_BOVIN Computationally mapped isoform of Transmembrane and immunoglobulin domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMIGD1 PE=4 SV=1 CANONICAL=A0AAA9SMA3-1" }, "locus": { "chromosome": "19", "start_pos": 21412340, "end_pos": 21399197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101286.1" } ] } }, { "isoform_ac": "F1MLX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3/entry#F1MLX4-1", "sequence": { "sequence": "FPRAATFGSVLSVNGKTENYILDTEPGLQESLKCAVQNHIRDEELLWYREDGRVDLKSGNKINSSSVCVSGISEDDNGITFTCKLQRNQSVSISVVLNVTFPPLLSGNDFQTAEEGSDVKLVCNVKSNPQAQMMWYKNNGILNLENHHQIQQTSKYFQLSITKVKKSDNGTYSCIANSLIETKTKDFHLIVKDKGSTVPIEPIIAACVVVFLTLVFGVIARRKRIMKLCRKDQGPQCRTAL", "length": 241, "header": "tr|F1MLX4-1|A0AAA9SMA3_BOVIN Computationally mapped isoform of Transmembrane and immunoglobulin domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMIGD1 PE=4 SV=2 CANONICAL=A0AAA9SMA3-1" }, "locus": { "chromosome": "19", "start_pos": 21411821, "end_pos": 21399197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003375.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003375.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003375.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003375.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "regulation of membrane permeability", "id": "GO:0090559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090559", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" }, { "name": "cell adhesion mediator activity", "id": "GO:0098631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMA3" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 133, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 127, "end_pos": 129 }, { "start_pos": 137, "end_pos": 139 }, { "start_pos": 208, "end_pos": 210 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLC2-1", "uniprot_ac": "A0AAA9SLC2", "uniprot_id": "A0AAA9SLC2_BOVIN", "mass": { "chemical_mass": 51737.0, "monoisotopic_mass": 51737.0 }, "refseq": { "ac": "XP_005214244", "name": "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214244" }, "gene_names": [ { "name": "NSUN6", "type": "recommended", "evidence": [ { "id": "A0AAA9SLC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2" } ] }, { "name": "NSUN6", "type": "synonym", "evidence": [ { "id": "XP_005214244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214244" } ] } ], "protein_names": [ { "name": "NOP2/Sun RNA methyltransferase 6", "type": "synonym", "evidence": [ { "id": "A0AAA9SLC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2/entry#names_and_taxonomy" } ] }, { "name": "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214244" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NSUN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2", "locus": { "chromosome": "13", "start_pos": 32998276, "end_pos": 33078041, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022003", "url": "https://www.ensembl.org/id/ENSBTAG00000022003" } ] } } ], "crossref": [ { "id": "A0AAA9SLC2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21150", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21150", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511775", "url": "https://www.ncbi.nlm.nih.gov/gene/511775", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22807", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22807", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22807:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22807:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214244", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214244", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S349", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S349", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S349-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S349-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVFPKISLRLEVENYLKAGFMNKEILSALGKQEAERRFEMLLHNLSHPPSFTTVRVNTHLASVQHVKNLLFDELQKQFNGLSFPVLQHPDLQDVLLIPVIGPRKNIKQQTCEVIVGAQCGSAVLRGAHVYVPGIVSASKFMKGGDDVSVYSDIKGKCKKGAKEFDGTKIFLGNGISELSRKEIFSGLPELKGVGVRMTEPVYLSPSFDNVLPSYLFLQNLPSAVVSHVLDPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKISKKVEKIKQNALLLGLNSIRAFCFDGTKALKLDMVKDTDGEPPFLPESFDRILLDAPCSGMGQRPNMACTWTLKEVMSYQPLQRKLFTVAVELLKPGGMLVYSTCTVTLAENEEQVAWALEAFPGLQLQHQDPQVGGEGMLGAGLSPEQLKRLQRFDPSAMRSLDRDIGSLRDASIEDLVWLANKDCIGFFIAKFVKCKSTQ", "length": 470, "header": "tr|A0AAA9SLC2-1|A0AAA9SLC2_BOVIN Isoform 1 of NOP2/Sun RNA methyltransferase 6 OS=Bos taurus OX=9913 GN=NSUN6 PE=3 SV=1 CANONICAL=A0AAA9SLC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S349-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2/entry#A0AAA9S349-1", "sequence": { "sequence": "MSVFPKISLRLEVENYLKAGFMNKEILSALGKQEAERRFEMLLHNLSHPPSFTTVRVNTHLASVQHVKNLLFDELQKQFNGLSFPVLQHPDLQDVLLIPVIGPRKNIKQQTCEVIVGAQCGSAVLRGAHVYVPGIVSASKFMKGGDDVSVYSDIKGKCKKGAKEFDGTKIFLGNGISELSRKEIFSGLPELKGVGVRMTEPVYLSPSFDNVLPSYLFLQNLPSAVVSHVLDPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKISKKVEKIKQNALLLGLNSIRAFCFDGTKALKLDMVKDTDGEPPFLPESFDRILLDAPCSGMGQRPNMACTWTLKEVMSYQPLQRKLFTVDPQVGGEGMLGAGLSPEQLKRLQRFDPSAMRSLDRDIGSLRDASIEDLVWLANKDCIGFFIAKFVKCKSTQ", "length": 428, "header": "tr|A0AAA9S349-1|A0AAA9SLC2_BOVIN Computationally mapped isoform of NOP2/Sun RNA methyltransferase 6 OS=Bos taurus OX=9913 GN=NSUN6 PE=3 SV=1 CANONICAL=A0AAA9SLC2-1" }, "locus": { "chromosome": "13", "start_pos": 33077644, "end_pos": 32999280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078180.1" } ] } }, { "isoform_ac": "A0AAA9SLC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2/entry#A0AAA9SLC2-1", "sequence": { "sequence": "MSVFPKISLRLEVENYLKAGFMNKEILSALGKQEAERRFEMLLHNLSHPPSFTTVRVNTHLASVQHVKNLLFDELQKQFNGLSFPVLQHPDLQDVLLIPVIGPRKNIKQQTCEVIVGAQCGSAVLRGAHVYVPGIVSASKFMKGGDDVSVYSDIKGKCKKGAKEFDGTKIFLGNGISELSRKEIFSGLPELKGVGVRMTEPVYLSPSFDNVLPSYLFLQNLPSAVVSHVLDPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKISKKVEKIKQNALLLGLNSIRAFCFDGTKALKLDMVKDTDGEPPFLPESFDRILLDAPCSGMGQRPNMACTWTLKEVMSYQPLQRKLFTVAVELLKPGGMLVYSTCTVTLAENEEQVAWALEAFPGLQLQHQDPQVGGEGMLGAGLSPEQLKRLQRFDPSAMRSLDRDIGSLRDASIEDLVWLANKDCIGFFIAKFVKCKSTQ", "length": 470, "header": "tr|A0AAA9SLC2-1|A0AAA9SLC2_BOVIN Isoform 1 of NOP2/Sun RNA methyltransferase 6 OS=Bos taurus OX=9913 GN=NSUN6 PE=3 SV=1 CANONICAL=A0AAA9SLC2-1" }, "locus": { "chromosome": "13", "start_pos": 33077644, "end_pos": 32999280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096160.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096160.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087171.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2" } ], "pmid": "" }, { "name": "RNA methyltransferase activity", "id": "GO:0008173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008173", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "RNA methylation", "id": "GO:0001510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001510", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC2" }, { "id": "PS51686", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51686" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM-dependent MTase RsmB/NOP-type", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 466, "start_aa": "Phe", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIY2-1", "uniprot_ac": "A0AAA9SIY2", "uniprot_id": "A0AAA9SIY2_BOVIN", "mass": { "chemical_mass": 100792.0, "monoisotopic_mass": 100792.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF585A", "type": "recommended", "evidence": [ { "id": "A0AAA9SIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ] } ], "protein_names": [ { "name": "Zinc finger protein 585A", "type": "synonym", "evidence": [ { "id": "A0AAA9SIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S4L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4L9#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "F1MUP0", "url": "https://www.uniprot.org/uniprotkb/F1MUP0#function" }, { "database": "UniProtKB", "id": "A0AAA9SVN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN7#function" }, { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2#function" }, { "database": "UniProtKB", "id": "A0AAA9TNS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNS2#function" }, { "database": "UniProtKB", "id": "A0AAA9TWS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF585A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SIY2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040063", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040063", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767967", "url": "https://www.ncbi.nlm.nih.gov/gene/767967", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767967", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767967", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232:SF165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232:SF165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S4L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4L9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM84", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUP0", "url": "https://www.uniprot.org/uniprotkb/F1MUP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUP0-1", "url": "https://www.uniprot.org/uniprotkb/F1MUP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATHSSILAWKIPWTEEHGGLQTMELQRGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPEELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 880, "header": "tr|A0AAA9SIY2-1|A0AAA9SIY2_BOVIN Isoform 1 of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=1 CANONICAL=A0AAA9SIY2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAA9S4L9-1", "sequence": { "sequence": "MLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 820, "header": "tr|A0AAA9S4L9-1|A0AAA9SIY2_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47280728, "end_pos": 47273444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126256.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126256.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077079.1" } ] } }, { "isoform_ac": "A0AAA9SIY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAA9SIY2-1", "sequence": { "sequence": "MATHSSILAWKIPWTEEHGGLQTMELQRGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPEELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 880, "header": "tr|A0AAA9SIY2-1|A0AAA9SIY2_BOVIN Isoform 1 of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47283910, "end_pos": 47273444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100276.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100276.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083754.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083754.1" } ] } }, { "isoform_ac": "A0AAA9STM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAA9STM5-1", "sequence": { "sequence": "MTMPANWTSPQKSLGLAPEEPGGSCEGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKASENSYWRKTL", "length": 159, "header": "tr|A0AAA9STM5-1|A0AAA9STM5_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=4 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47288598, "end_pos": 47275110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088701.1" } ] } }, { "isoform_ac": "A0AAA9SVN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAA9SVN7-1", "sequence": { "sequence": "MGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPEELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 853, "header": "tr|A0AAA9SVN7-1|A0AAA9SVN7_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47286931, "end_pos": 47273444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121986.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121986.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087248.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087248.1" } ] } }, { "isoform_ac": "A0AAA9TNS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAA9TNS2-1", "sequence": { "sequence": "MTMPANWTSPQKSLGLAPEEPGGSCEGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPEELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 878, "header": "tr|A0AAA9TNS2-1|A0AAA9TNS2_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47288598, "end_pos": 47273444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129162.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129162.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100216.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100216.1" } ] } }, { "isoform_ac": "A0AAA9TWS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAA9TWS2-1", "sequence": { "sequence": "MTMPANWTSPQKSLGLAPEEPGGSCEGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIEELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 847, "header": "tr|A0AAA9TWS2-1|A0AAA9TWS2_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47288598, "end_pos": 47273444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104389.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104389.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101625.1" } ] } }, { "isoform_ac": "A0AAF6DM84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#A0AAF6DM84-1", "sequence": { "sequence": "MTMPANWTSPQKSLGLAPEEPGGSCEGSVSFRDVAVDFSREEWQQLDLDQKNLYRDVMLETCSHLLSIEWSSY", "length": 73, "header": "tr|A0AAF6DM84-1|A0AAF6DM84_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=4 SV=1 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47288598, "end_pos": 47278044, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000051893.4", "url": "https://www.ensembl.org/id/ENSBTAT00000051893.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048235.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048235.4" } ] } }, { "isoform_ac": "F1MUP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2/entry#F1MUP0-1", "sequence": { "sequence": "MLETCSHLLSIGYQVPETKVFMLEQGKEPWALQGEGPYQSCPEELWQIGDQIESYHQRENRSLRNVAFIKKVLTIQRDYAYKGITKIIRVSQNIPSPKRPHHQCDLFGSALSCNLDLCNNNRNSGSKNINKITEYGKISSYTKQECTPTGEKLRDHNQCGKILNYKQVPSQHQKIHTGVKFYECPEFGNIFTQNSQLKVHLKVHTGEKLYVCIDCGKAFVQKPEFITHQRTHTREKPYKCSECGKAFFQVSSLFRHQRIHTGEKLYECSECGKGFSYNSDLSIHQKIHTGERHHECSECGKAFTQKSTLKMHQKIHTGERSYICIECGQAFIQKTHLIAHRRIHTGEKPYKCSNCGKSFISKSQLQVHQRTHTRMKPSMCSEYGNVFNNNSNLNTHKKVQIREKSSICTECGKAFTYRSELVIHQRIHTGEKPYECSDCGKAFTQKSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPYKCGHCGKSFTSKSQLHVHKRIHTGEKPYTCTKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECSTCGKSFTQKSHLNIHQKIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPYECSDCGKSFTSKSQLLVHQPIHTGEKPYVCALCGKAFSGRSNLSKHQKTHTGEKPYICSECGKTFRQKSELIIHHRIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECGKAFTDRSNLNKHQTTHTGDKPYKCVVCGKGFVQKSVLNVHQSIHT", "length": 821, "header": "tr|F1MUP0-1|F1MUP0_BOVIN Computationally mapped isoform of Zinc finger protein 585A OS=Bos taurus OX=9913 GN=ZNF585A PE=3 SV=4 CANONICAL=A0AAA9SIY2-1" }, "locus": { "chromosome": "18", "start_pos": 47280728, "end_pos": 47273444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057256.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057256.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051211.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051211.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767967", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767967", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 759, "end_pos": 761, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 241, "end_pos": 268, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIY2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 101, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 448, "end_pos": 450 }, { "start_pos": 588, "end_pos": 590 }, { "start_pos": 759, "end_pos": 761 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIN8-1", "uniprot_ac": "A0AAA9SIN8", "uniprot_id": "A0AAA9SIN8_BOVIN", "mass": { "chemical_mass": 38278.0, "monoisotopic_mass": 38278.0 }, "refseq": {}, "gene_names": [ { "name": "JKAMP", "type": "recommended", "evidence": [ { "id": "A0AAA9SIN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8" } ] } ], "protein_names": [ { "name": "JNK1/MAPK8 associated membrane protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SIN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JKAMP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8", "locus": { "chromosome": "10", "start_pos": 71782133, "end_pos": 71759930, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003371", "url": "https://www.ensembl.org/id/ENSBTAG00000003371" } ] } } ], "crossref": [ { "id": "A0AAA9SIN8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003371", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003371", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CPGIYCG", "url": "https://omabrowser.org/oma/group/CPGIYCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12740:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12740:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S610", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S610", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S610-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S610-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q4I0", "url": "https://www.uniprot.org/uniprotkb/F6Q4I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q4I0-1", "url": "https://www.uniprot.org/uniprotkb/F6Q4I0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIFQEKVNFPNSRLTRTYSTVGYGFFEAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECTVAALVTLLVSEPVGVLHIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH", "length": 337, "header": "tr|A0AAA9SIN8-1|A0AAA9SIN8_BOVIN Isoform 1 of JNK1/MAPK8 associated membrane protein OS=Bos taurus OX=9913 GN=JKAMP PE=4 SV=1 CANONICAL=A0AAA9SIN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S610-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8/entry#A0AAA9S610-1", "sequence": { "sequence": "IKGESERTVGARVVCLFFFLTVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECTVAALVTLLVSEPVGVLHIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH", "length": 330, "header": "tr|A0AAA9S610-1|A0AAA9SIN8_BOVIN Computationally mapped isoform of JNK1/MAPK8 associated membrane protein OS=Bos taurus OX=9913 GN=JKAMP PE=4 SV=1 CANONICAL=A0AAA9SIN8-1" }, "locus": { "chromosome": "10", "start_pos": 71781350, "end_pos": 71760517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107978.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107978.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077603.1" } ] } }, { "isoform_ac": "A0AAA9SIN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8/entry#A0AAA9SIN8-1", "sequence": { "sequence": "MIFQEKVNFPNSRLTRTYSTVGYGFFEAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECTVAALVTLLVSEPVGVLHIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH", "length": 337, "header": "tr|A0AAA9SIN8-1|A0AAA9SIN8_BOVIN Isoform 1 of JNK1/MAPK8 associated membrane protein OS=Bos taurus OX=9913 GN=JKAMP PE=4 SV=1 CANONICAL=A0AAA9SIN8-1" }, "locus": { "chromosome": "10", "start_pos": 71781350, "end_pos": 71761466, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126675.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126675.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082410.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082410.1" } ] } }, { "isoform_ac": "F6Q4I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8/entry#F6Q4I0-1", "sequence": { "sequence": "AVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECTVAALVTLLVSEPVGVLHIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH", "length": 310, "header": "tr|F6Q4I0-1|F6Q4I0_BOVIN Computationally mapped isoform of JNK1/MAPK8 associated membrane protein OS=Bos taurus OX=9913 GN=JKAMP PE=4 SV=1 CANONICAL=A0AAA9SIN8-1" }, "locus": { "chromosome": "10", "start_pos": 71781350, "end_pos": 71762426, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004373.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004373.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004373.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004373.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 312, "start_aa": "Thr", "end_pos": 312, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr312", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 312 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ15-1", "uniprot_ac": "A0AAA9SJ15", "uniprot_id": "A0AAA9SJ15_BOVIN", "mass": { "chemical_mass": 17941.0, "monoisotopic_mass": 17941.0 }, "refseq": { "ac": "XP_010803935", "name": "ninjurin-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803935" }, "gene_names": [ { "name": "NINJ2", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ] }, { "name": "NINJ2", "type": "synonym", "evidence": [ { "id": "XP_010803935", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803935" } ] } ], "protein_names": [ { "name": "Ninjurin 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15/entry#names_and_taxonomy" } ] }, { "name": "ninjurin-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010803935", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803935" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NINJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15", "locus": { "chromosome": "5", "start_pos": 107436495, "end_pos": 107440389, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008554", "url": "https://www.ensembl.org/id/ENSBTAG00000008554" } ] } } ], "crossref": [ { "id": "A0AAA9SJ15", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ15", "database": "AlphaFoldDB", "categories": [] }, { "id": "509556", "url": "https://www.ncbi.nlm.nih.gov/gene/509556", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12316", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12316", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12316:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12316:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010803935", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803935", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRLKTRPVLSRDCRLPAAFRLPPAPTALLVTLSFRPGSPSPGSSPLVNLNRYATKKSLAESLLDMALFMSNAVQLKAVLDRGPSSYNYFALVTLLSISLILQVVIGILLVVMALLNLNEVEKQWRLNQLNNAATALIFITVMINIFITAFGAHRIGLLAAGTPL", "length": 165, "header": "tr|A0AAA9SJ15-1|A0AAA9SJ15_BOVIN Isoform 1 of Ninjurin 2 OS=Bos taurus OX=9913 GN=NINJ2 PE=3 SV=1 CANONICAL=A0AAA9SJ15-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15/entry#A0AAA9S7R3-1", "sequence": { "sequence": "MGKTRLGDLFPSHSDASRMALTPRLWPGSPSPGSSPLVNLNRYATKKSLAESLLDMALFMSNAVQLKAVLDRGPSSYNYFALVTLLSISLILQVVIGILLVVMALLNLNEVEKQWRLNQLNNAATALIFITVMINIFITAFGAHRIGLLAAGTPL", "length": 155, "header": "tr|A0AAA9S7R3-1|A0AAA9SJ15_BOVIN Computationally mapped isoform of Ninjurin 2 OS=Bos taurus OX=9913 GN=NINJ2 PE=3 SV=1 CANONICAL=A0AAA9SJ15-1" }, "locus": { "chromosome": "5", "start_pos": 107440190, "end_pos": 107437308, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093084.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093084.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079333.1" } ] } }, { "isoform_ac": "A0AAA9SJ15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15/entry#A0AAA9SJ15-1", "sequence": { "sequence": "MNRLKTRPVLSRDCRLPAAFRLPPAPTALLVTLSFRPGSPSPGSSPLVNLNRYATKKSLAESLLDMALFMSNAVQLKAVLDRGPSSYNYFALVTLLSISLILQVVIGILLVVMALLNLNEVEKQWRLNQLNNAATALIFITVMINIFITAFGAHRIGLLAAGTPL", "length": 165, "header": "tr|A0AAA9SJ15-1|A0AAA9SJ15_BOVIN Isoform 1 of Ninjurin 2 OS=Bos taurus OX=9913 GN=NINJ2 PE=3 SV=1 CANONICAL=A0AAA9SJ15-1" }, "locus": { "chromosome": "5", "start_pos": 107438935, "end_pos": 107437308, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109654.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109654.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083909.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083909.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ], "pmid": "" }, { "name": "tissue regeneration", "id": "GO:0042246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ15" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIT7-1", "uniprot_ac": "A0AAA9SIT7", "uniprot_id": "A0AAA9SIT7_BOVIN", "mass": { "chemical_mass": 162146.0, "monoisotopic_mass": 162146.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SIT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000050359", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050359", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TQCENRE", "url": "https://omabrowser.org/oma/group/TQCENRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47772", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47772", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47772:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47772:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LVN0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVN0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NN71", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NN71-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NN71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKENKSGMTLSQTQLTVEDVDIKFTPEEWECLDPAQRALYWDVMEETYRNLLSVDVSHIHMTKKLQAKGNSGKGKNFQTVMFVRAETHEIKDFFLRKIEKTVHGFEYLWTDDDRSDNGISISHNKNLTDGKDHQSRNDAADKPVERLRSSFHDELRMLQSEGTIFECSRVVTNINSSTSVLPIQRTCSVRKGISYNENPVVHPSEQAPDREAYKKKSYKTRDCGLTFLQHSELIRRQRILTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKQSHSLHQILHTGEKPYKCDRCGHGYTRKSRLVIHHRVHTGENPYKCDICGCDLNGKRQLRTHRRSHTEVKSYKCNTCGKSFFALSSLNKHQAVQTDKKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDLCGCGYPRKSQLVIHQRIHAGENRYKCDVCGCGFTGNRQLRTHRRIHTEVKSYKCNNCGKRFFALSSLSKHQAVQIDEKACKCNLCGKIFSSRCYLAVHQRIHIGEKPYKCIVCGCGYTRKSQLGIHHKVHTGEKPYKCDVCGCDFTGRRQLRNHQRIHTEVKSYKCNNCGKLFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1418, "header": "tr|A0AAA9SIT7-1|A0AAA9SIT7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SIT7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#A0A3Q1LVN0-1", "sequence": { "sequence": "MTKKLQAKGNSGKGKNFQTVMFVRAETHEIKDFFLRKIEKTVHGFEYLWTDDDRSDNGISISHNKNLTDGKDHQSRNDAADKPVERLRSSFHDELRMLQSEGTIFECSRVVTNINSSTSVLPIQRTCSVRKGISYNENPVVHPSEQAPDREAYKKKSYKTRDCGLTFLQHSELIRRQRILTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKQSHSLHQILHTGEKPYKCDRCGHGYTRKSRLVIHHRVHTGENPYKCDICGCDLNGKRQLRTHRRSHTEVKSYKCNTCGKSFFALSSLNKHQAVQTDKKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDLCGCGYPRKSQLVIHQRIHAGENRYKCDVCGCGFTGNRQLRTHRRIHTEVKSYKCNNCGKRFFALSSLSKHQAVQIDEKACKCNLCGKIFSSRCYLAVHQRIHIGEKPYKCIVCGCGYTRKSQLGIHHKVHTGEKPYKCDVCGCDFTGRRQLRNHQRIHTEVKSYKCNNCGKLFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1358, "header": "tr|A0A3Q1LVN0-1|A0A3Q1LVN0_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SIT7-1" }, "locus": { "chromosome": "18", "start_pos": 59301666, "end_pos": 59297593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072682.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072682.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061474.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061474.2" } ] } }, { "isoform_ac": "A0AAA9S7U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#A0AAA9S7U6-1", "sequence": { "sequence": "MKENKSGMTLSQTQLTVEDVDIKFTPEEWECLDPAQRALYWDVMEETYRNLLSVDVSHIHMTKKLQAKGNSGKGKNFQTVMFVRAETHEIKDFFLRKIEKTVHGFEYLWTDDDRSDNGISISHNKNLTDGKDHQSRNDAADKPVERLRSSFHDELRMLQSEGTIFECSRVVTNINSSTSVLPIQRTCSVRKGISYNENPVVHPSEQAPDREAYKKKSYKTRDCGLTFLQHSELIRRQRILTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKQSHSLHQILHTGEKPYKCDRCGHGYTRKSRLVIHHRVHTGENPYKCDICGCDLNGKRQLRTHRRSHTEVKSYKCNTCGKSFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1194, "header": "tr|A0AAA9S7U6-1|A0AAA9SIT7_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SIT7-1" }, "locus": { "chromosome": "18", "start_pos": 59311809, "end_pos": 59297593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127773.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127773.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079374.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079374.1" } ] } }, { "isoform_ac": "A0AAA9SFV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#A0AAA9SFV4-1", "sequence": { "sequence": "MKENKSGMTLSQTQLTVEDVDIKFTPEEWECLDPAQRALYWDVMEETYRNLLSVDVSHIHMTKKLQAKGNSGKGKNFQTVMFVRAETHEIKDFFLRKIEKTVHGFEYLWTDDDRSDNGISISHNKNLTDGKDHQSRNDAADKPVERLRSSFHDELRMLQSEGTIFECSRVVTNINSSTSVLPIQRTCSVRKGISYNENPVVHPSEQAPDREAYKKKSYKTRDCGLTFLQHSELIRRQRILTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDLCGCGYPRKSQLVIHQRIHAGENRYKCDVCGCGFTGNRQLRTHRRIHTEVKSYKCNNCGKRFFALSSLSKHQAVQIDEKACKCNLCGKIFSSRCYLAVHQRIHIGEKPYKCIVCGCGYTRKSQLGIHHKVHTGEKPYKCDVCGCDFTGRRQLRNHQRIHTEVKSYKCNNCGKLFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1278, "header": "tr|A0AAA9SFV4-1|A0AAA9SIT7_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SIT7-1" }, "locus": { "chromosome": "18", "start_pos": 59311809, "end_pos": 59297593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089951.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089951.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082759.1" } ] } }, { "isoform_ac": "A0AAA9SIT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#A0AAA9SIT7-1", "sequence": { "sequence": "MKENKSGMTLSQTQLTVEDVDIKFTPEEWECLDPAQRALYWDVMEETYRNLLSVDVSHIHMTKKLQAKGNSGKGKNFQTVMFVRAETHEIKDFFLRKIEKTVHGFEYLWTDDDRSDNGISISHNKNLTDGKDHQSRNDAADKPVERLRSSFHDELRMLQSEGTIFECSRVVTNINSSTSVLPIQRTCSVRKGISYNENPVVHPSEQAPDREAYKKKSYKTRDCGLTFLQHSELIRRQRILTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKQSHSLHQILHTGEKPYKCDRCGHGYTRKSRLVIHHRVHTGENPYKCDICGCDLNGKRQLRTHRRSHTEVKSYKCNTCGKSFFALSSLNKHQAVQTDKKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDLCGCGYPRKSQLVIHQRIHAGENRYKCDVCGCGFTGNRQLRTHRRIHTEVKSYKCNNCGKRFFALSSLSKHQAVQIDEKACKCNLCGKIFSSRCYLAVHQRIHIGEKPYKCIVCGCGYTRKSQLGIHHKVHTGEKPYKCDVCGCDFTGRRQLRNHQRIHTEVKSYKCNNCGKLFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1418, "header": "tr|A0AAA9SIT7-1|A0AAA9SIT7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SIT7-1" }, "locus": { "chromosome": "18", "start_pos": 59311809, "end_pos": 59297593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093563.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093563.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083693.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083693.2" } ] } }, { "isoform_ac": "A0AAA9SRQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#A0AAA9SRQ6-1", "sequence": { "sequence": "MYLGAHEPNVSHIHMTKKLQAKGNSGKGKNFQTVMFVRAETHEIKDFFLRKIEKTVHGFEYLWTDDDRSDNGISISHNKNLTDGKDHQSRNDAADKPVERLRSSFHDELRMLQSEGTIFECSRVVTNINSSTSVLPIQRTCSVRKGISYNENPVVHPSEQAPDREAYKKKSYKTRDCGLTFLQHSELIRRQRILTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKQSHSLHQILHTGEKPYKCDRCGHGYTRKSRLVIHHRVHTGENPYKCDICGCDLNGKRQLRTHRRSHTEVKSYKCNTCGKSFFALSSLNKHQAVQTDKKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDLCGCGYPRKSQLVIHQRIHAGENRYKCDVCGCGFTGNRQLRTHRRIHTEVKSYKCNNCGKRFFALSSLSKHQAVQIDEKACKCNLCGKIFSSRCYLAVHQRIHIGEKPYKCIVCGCGYTRKSQLGIHHKVHTGEKPYKCDVCGCDFTGRRQLRNHQRIHTEVKSYKCNNCGKLFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1372, "header": "tr|A0AAA9SRQ6-1|A0AAA9SRQ6_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SIT7-1" }, "locus": { "chromosome": "18", "start_pos": 59302657, "end_pos": 59297593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104024.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104024.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086647.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086647.2" } ] } }, { "isoform_ac": "A0ABI0NN71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7/entry#A0ABI0NN71-1", "sequence": { "sequence": "MSISHNRNLTGGRDHQSRNDVGDKPIKMHISSFHDELQMLQSEGTLFECSQVVMNINSSASGLPPQRMCRVHKGISHKHESAVMHSSELAPDQESHKKKSYKCNECDIMFLQDSELTRHQRIHTGRKPYKADIGGKAFNDNESLAVHRRNHTGEKPYKCDVCGHSFKQKTALQIHLRVHTGERPYKCDVCGHSFKHKTHLQNHGRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLRIHRRVHTGEKPYTCDVCGKTFSRKEGCALHQILHTGEKPYKCDVCGRGYIRKSQLGIHQRIHTGEKPYKCDVCGKAFTRKESHVLHQILHTGEKPYKCDVCGQAFTRKESHALHKILHTGEKPYKCDVCGRGYTRSTQLAIHWRLHTGEKPYQCDVCGHGYPRKSQLVIHQRIHIRENPYKCNVCGCGFTGKRQLRIHRRTHTEVKSYKCNNCGKRFFALFSLNKHQAVQTDEKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKQSHSLHQILHTGEKPYKCDRCGHGYTRKSRLVIHHRVHTGENPYKCDICGCDLNGKRQLRTHRRSHTEVKSYKCNTCGKSFFALSSLNKHQAVQTDKKACKCNLCGKMFSSRCYLAVHQRTHTGEKPYKCDLCGCGYPRKSQLVIHQRIHAGENRYKCDVCGCGFTGNRQLRTHRRIHTEVKSYKCNNCGKRFFALSSLSKHQAVQIDEKACKCNLCGKIFSSRCYLAVHQRIHIGEKPYKCIVCGCGYTRKSQLGIHHKVHTGEKPYKCDVCGCDFTGRRQLRNHQRIHTEVKSYKCNNCGKLFFALSSLNKHQAVQSDEKACKCNLCGKMFSSKCCLAVHQRTHTGEKPYKCDVCGKAFTRKESCALHQILHTGEKPYKCDVCGRGYTRKSQLEIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDVCGRGYIRKSKLGIHQRIHTGENSYKCDVCGRGFTGNRQLGIHRRIHTEVKPFQCNSCDKRFFTRASLKIHEVVHTDEKARKCTLCGKVFSSRCYLAVHQRTHTGEKPYKCDVCGKAFTRKESHAVHQILHTGEKPYKCDVCGRGYTRSTQLAVHQRVHTGEKPYKCDVCGKAFRVNGSLTSHRKIHCREKPYKCDVCGKAFSVNGSLRTHQKIHTGEKPYKCDVCGKAFRVNGTLTSHQKIHTGEKPYKCDVCGKAFTINGSLATHRKIHTGEKPYKCDICGKAFSLNGSLTYHQKIHSDEKPYQCGVCGKAFRVKGSLTSHQKIHTG", "length": 1301, "header": "tr|A0ABI0NN71-1|A0ABI0NN71_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SIT7-1" }, "locus": { "chromosome": "18", "start_pos": 59356054, "end_pos": 59297593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141816.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141816.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106730.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q9VBR8-1", "protein_name": "Zinc finger protein Xfin", "gene_name": "anon-96CDa", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLPSDVCRTCAVQNSQLLPLSTCLDKDSSKSYYAVLQELTQIDLENTDDNLPQHICSECWRRMESAYTFVQQARKVHGELLAQLRECLDELPIDIPAEQNIKTEVDLDDGGNKSEVEVDDTEATALELKWQPASGSDREFCSGPESDEDQVEKKSYHLRRSSRKVKHPVESENEECKPSEPSPVKRRRGRPPGPAKSQAMTTDGRHACEVCGKTFSWYRDMQRHARIHFENASYVCDTCGKGFLRKDKYIFHLRCHKKREAKWKALQLGKEWRFAERLYSSGKLKRIECKLCGLSCQRMEELRAHLWDHADTETLVNLRTDSDVVREHFPGLPCDLDNIKKQICVDIADGHLEKYACVVNFHGYELGLSDSDEECDSKESKYHCFVCNMSFNRKHRLMKHTLEDHSQSATTLPWQRCSSCKVGFLCLTMYNKHLNTHCQSKIRRYRCRKCSGRFMWPENLQRHACSHREEKTIASQILCSLCDISLSSLSQLRLHLITHQHDLNGISPEYNSLFFRSFYPDGLNCSISDLAVRIAEDFEVQDFDRYYNASTESGQELDLFESETELSDEETSKTSHICLLCGETSNSLMNLMKHQICLHSDGVAELPCRCDYCGSGFVSKALLQQHRRHRCEKKHSRFHCRICNIRFIWESNYEKHEKTHHNKTKDAEERPTKLKCDQCEKVFIWHKDLNRHKRLHQPQSAAQFDCPHCHRRFHRKDGLKSHLKVHAGNSDYINNQPVVPDVNQEMILARLSRPHGCKLIQCMICLSRHSKISDLRSHLSSHQYELSFAEDRDIPSASKAFYPDLENTLEKDELAEMIMADVQREFDLDRFISITNEAGLELNLESSETDTESEQEDNHSSLNYPCNLCTTVVKRKHQLYAHQLEEHKWEEAVLVCSNCQTRFVNESLLDHHSRTLCHNPQKLFQCRKCPLRFRWRENLKLHMEVFHMLDELSIQDDLPKVDGDLQCGKCNRSFRMQKDLTRHTLMHGQESNIFRCRWCARRFYRRANLLQHIARHGISVSQLPYAEAILDSYVNPGGRKKVECRVCNVSFPTIAALRLHLETMPAGSHHDYSSLQNYSITNQMGFEMDLYDSETDDEDSRTHIKPPGAPSSYTCNMCQLRCLRKFELYQHQQAMHRMEKISDGCDSCLFKSVCPEIISHHKRTQCENREKQFKCTRCGYKFMWESNLLLHMDLQHVKTEDQELDESKEASGDEPKTEGQVFQCGLCTRKYNRKDRLTAHLKKFHGPDCKPSTAKTPNRPISPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCEYCTMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRMQQSHYEEGQESVEPTRRTVLEQFTL", "length": 1426 }, "evidence": [ { "id": "A0AAA9SIT7", "url": "https://omabrowser.org/oma/group/A0AAA9SIT7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear lumen", "id": "GO:0031981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1266, "end_pos": 1268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1294, "end_pos": 1296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1322, "end_pos": 1324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1350, "end_pos": 1352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1378, "end_pos": 1380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 218, "end_pos": 245, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SIT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIT7" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 90, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1266, "end_pos": 1268 }, { "start_pos": 126, "end_pos": 128 }, { "start_pos": 1294, "end_pos": 1296 }, { "start_pos": 1322, "end_pos": 1324 }, { "start_pos": 1350, "end_pos": 1352 }, { "start_pos": 1378, "end_pos": 1380 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 258, "end_pos": 260 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJG9-1", "uniprot_ac": "A0AAA9SJG9", "uniprot_id": "A0AAA9SJG9_BOVIN", "mass": { "chemical_mass": 95574.0, "monoisotopic_mass": 95574.0 }, "refseq": { "ac": "XP_005202184", "name": "biotin--protein ligase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202184" }, "gene_names": [ { "name": "HLCS", "type": "recommended", "evidence": [ { "id": "A0AAA9SJG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ] }, { "name": "HLCS", "type": "synonym", "evidence": [ { "id": "XP_005202184", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202184" } ] } ], "protein_names": [ { "name": "Holocarboxylase synthetase", "type": "synonym", "evidence": [ { "id": "A0AAA9SJG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9/entry#names_and_taxonomy" } ] }, { "name": "biotin--protein ligase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202184", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202184" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HLCS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9", "locus": { "chromosome": "1", "start_pos": 149028011, "end_pos": 149221581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033679", "url": "https://www.ensembl.org/id/ENSBTAG00000033679" } ] } } ], "crossref": [ { "id": "A0AAA9SJG9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033679", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033679", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16442", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16442", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534247", "url": "https://www.ncbi.nlm.nih.gov/gene/534247", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534247", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534247", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12835", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12835", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12835:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12835:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03099", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03099", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005202184", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202184", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S868", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S868", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S868-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S868-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG29", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJL3", "url": "https://www.uniprot.org/uniprotkb/F1MJL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJL3-1", "url": "https://www.uniprot.org/uniprotkb/F1MJL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLITLCYLYLWARWGRGPAALVRATVQRLRASRCSFTFCSAAAPPRGSRVCLSRGGRVFCVGESQSIDDLNKWALFLVSPFILEAEHIAFVTESIWVQGENLQTPASSSETIVKWSDCCLPLACRPGDPYQLIAKASVDDFSKLGVAFLEDRLQMANGLIPQKIVSVHLQDSALKELKGQASDLPAQLLQPDPESCIERNPPEPDTMEDPQSPGSVSTRGPGGAPGGSEPAMDGDRGVGSIEHCPLHLSSCHECLELENSTIESVRFASAENIPDLPYDYSSGLEGLDDDLRPERDERRVNVMGKAPNILLYVGSDSRDGQDRLQQVRSALADCVDTDCYTLYHLPPENALRDPWPDNCLLLVIATGEPVPEDLSRRFMAYLSQGGKVLALASSFTLPGFRVTSKSPLQDTVQSLVFCKADGSLLRLSILSSGCVYEEGPGEPLDPSKLHGHLDSEDGDRLVVQVPFGIHGGEAVLCQVHLELPPSSPVVQTQEDFNLLKSSNFRRYEVLTEILTTLGLSCDAKQAPALTPLYLLTATEEIWGPLVQWLGKHVDPEGVIRSSKVSLKFISSYTSEIEITPSAIPVVTDTESCSSENFDFEIYRQNLKTKKLGKVILFAEVTPTTMNLLDGLMFEMPQEMGLIAIAVRQTQGKGRGKNAWLSPLGCALSTLLVCIPLRSALGQRIPFVQHLMSLAVVEAVRSIPGYQDINLRVKWPNDIYYSDLMKLGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKEHGAQLQPLRADCLIARTVTVLEKLIDVFQDQGPNGVLPLYYKYWVHSAQQVCLGSAEGPQAWIAGLDDSGFLLVHQEDGDVVTVHPDGNSFDMLRNLIVPKQQ", "length": 872, "header": "tr|A0AAA9SJG9-1|A0AAA9SJG9_BOVIN Isoform 1 of Holocarboxylase synthetase OS=Bos taurus OX=9913 GN=HLCS PE=3 SV=1 CANONICAL=A0AAA9SJG9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S868-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9/entry#A0AAA9S868-1", "sequence": { "sequence": "MLITLCYLYLWARWGRGPAALVRATVQRLRASRCSFTFCSAAAPPRGSRVCLSRGGRVFCVGESQIVKWSDCCLPLACRPGDPYQLIAKASVDDFSKLGVAFLEDRLQMANGLIPQKIVSVHLQDSALKELKGQASDLPAQLLQPDPESCIERNPPEPDTMEDPQSPGSVSTRGPGGAPGGSEPAMDGDRGVGSIEHCPLHLSSCHECLELENSTIESVRFASAENIPDLPYDYSSGLEGLDDDLRPERDERRVNVMGKAPNILLYVGSDSRDGQDRLQQVRSALADCVDTDCYTLYHLPPENALRDPWPDNCLLLVIATGEPVPEDLSRRFMAYLSQGGKVLALASSFTLPGFRVTSKSPLQDTVQSLVFCKADGSLLRLSILSSGCVYEEGPGEPLDPSKLHGHLDSEDGDRLVVQVPFGIHGGEAVLCQVHLELPPSSPVVQTQEDFNLLKSSNFRRYEVLTEILTTLGLSCDAKQAPALTPLYLLTATEEIWGPLVQWLGKHVDPEGVIRSSKVSLKFISSYTSEIEITPSAIPVVTDTESCSSENFDFEIYRQNLKTKKLGKVILFAEVTPTTMNLLDGLMFEMPQEMGLIAIAVRQTQGKGRGKNAWLSPLGCALSTLLVCIPLRSALGQRIPFVQHLMSLAVVEAVRSIPGYQDINLRVKWPNDIYYSDLMKLGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKEHGAQLQPLRADCLIARTVTVLEKLIDVFQDQGPNGVLPLYYKYWVHSAQQVCLGSAEGPQAWIAGLDDSGFLLVHQEDGDVVTVHPDGNSFDMLRNLIVPKQQ", "length": 826, "header": "tr|A0AAA9S868-1|A0AAA9SJG9_BOVIN Computationally mapped isoform of Holocarboxylase synthetase OS=Bos taurus OX=9913 GN=HLCS PE=3 SV=1 CANONICAL=A0AAA9SJG9-1" }, "locus": { "chromosome": "1", "start_pos": 149221509, "end_pos": 149031199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095236.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095236.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082239.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082239.1" } ] } }, { "isoform_ac": "A0AAA9SG29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9/entry#A0AAA9SG29-1", "sequence": { "sequence": "MANGLIPQKIVSVHLQDSALKELKGQASDLPAQLLQPDPESCIERNPPEPDTMEDPQSPGSVSTRGPGGAPGGSEPAMDGDRGVGSIEHCPLHLSSCHECLELENSTIESVRFASAENIPDLPYDYSSGLEGLDDDLRPERDERRVNVMGKAPNILLYVGSDSRDGQDRLQQVRSALADCVDTDCYTLYHLPPENALRDPWPDNCLLLVIATGEPVPEDLSRRFMAYLSQGGKVLALASSFTLPGFRVTSKSPLQDTVQSLVFCKADGSLLRLSILSSGCVYEEGPGEPLDPSKLHGHLDSEDGDRLVVQVPFGIHGGEAVLCQEIWGPLVQWLGKHVDPEGVIRSSKVSLKFISSYTSEIEITPSAIPVVTDTESCSSENFDFEIYRQNLKTKKLGKVILFAEVTPTTMNLLDGLMFEMPQEMGLIAIAVRQTQGKGRGKNAWLSPLGCALSTLLVCIPLRSALGQRIPFVQHLMSLAVVEAVRSIPGYQDINLRVKWPNDIYYSDLMKLGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKEHGAQLQPLRADCLIARTVTVLEKLIDVFQDQGPNGVLPLYYKYWVHSAQQVCLGSAEGPQAWIAGLDDSGFLLVHQEDGDVVTVHPDGNSFDMLRNLIVPKQQ", "length": 657, "header": "tr|A0AAA9SG29-1|A0AAA9SJG9_BOVIN Computationally mapped isoform of Holocarboxylase synthetase OS=Bos taurus OX=9913 GN=HLCS PE=3 SV=1 CANONICAL=A0AAA9SJG9-1" }, "locus": { "chromosome": "1", "start_pos": 149200198, "end_pos": 149031199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118814.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118814.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081424.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081424.1" } ] } }, { "isoform_ac": "A0AAA9SJG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9/entry#A0AAA9SJG9-1", "sequence": { "sequence": "MLITLCYLYLWARWGRGPAALVRATVQRLRASRCSFTFCSAAAPPRGSRVCLSRGGRVFCVGESQSIDDLNKWALFLVSPFILEAEHIAFVTESIWVQGENLQTPASSSETIVKWSDCCLPLACRPGDPYQLIAKASVDDFSKLGVAFLEDRLQMANGLIPQKIVSVHLQDSALKELKGQASDLPAQLLQPDPESCIERNPPEPDTMEDPQSPGSVSTRGPGGAPGGSEPAMDGDRGVGSIEHCPLHLSSCHECLELENSTIESVRFASAENIPDLPYDYSSGLEGLDDDLRPERDERRVNVMGKAPNILLYVGSDSRDGQDRLQQVRSALADCVDTDCYTLYHLPPENALRDPWPDNCLLLVIATGEPVPEDLSRRFMAYLSQGGKVLALASSFTLPGFRVTSKSPLQDTVQSLVFCKADGSLLRLSILSSGCVYEEGPGEPLDPSKLHGHLDSEDGDRLVVQVPFGIHGGEAVLCQVHLELPPSSPVVQTQEDFNLLKSSNFRRYEVLTEILTTLGLSCDAKQAPALTPLYLLTATEEIWGPLVQWLGKHVDPEGVIRSSKVSLKFISSYTSEIEITPSAIPVVTDTESCSSENFDFEIYRQNLKTKKLGKVILFAEVTPTTMNLLDGLMFEMPQEMGLIAIAVRQTQGKGRGKNAWLSPLGCALSTLLVCIPLRSALGQRIPFVQHLMSLAVVEAVRSIPGYQDINLRVKWPNDIYYSDLMKLGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKEHGAQLQPLRADCLIARTVTVLEKLIDVFQDQGPNGVLPLYYKYWVHSAQQVCLGSAEGPQAWIAGLDDSGFLLVHQEDGDVVTVHPDGNSFDMLRNLIVPKQQ", "length": 872, "header": "tr|A0AAA9SJG9-1|A0AAA9SJG9_BOVIN Isoform 1 of Holocarboxylase synthetase OS=Bos taurus OX=9913 GN=HLCS PE=3 SV=1 CANONICAL=A0AAA9SJG9-1" }, "locus": { "chromosome": "1", "start_pos": 149221509, "end_pos": 149031199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120155.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120155.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085482.1" } ] } }, { "isoform_ac": "F1MJL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9/entry#F1MJL3-1", "sequence": { "sequence": "MQCTGEHRMALMYMPPGITKSIDDLNKWALFLVSPFILEAEHIAFVTESIWVQGENLQTPASSSETIVKWSDCCLPLACRPGDPYQLIAKASVDDFSKLGVAFLEDRLQMANGLIPQKIVSVHLQDSALKELKGQASDLPAQLLQPDPESCIERNPPEPDTMEDPQSPGSVSTRGPGGAPGGSEPAMDGDRGVGSIEHCPLHLSSCHECLELENSTIESVRFASAENIPDLPYDYSSGLEGLDDDLRPERDERRVNVMGKAPNILLYVGSDSRDGQDRLQQVRSALADCVDTDCYTLYHLPPENALRDPWPDNCLLLVIATGEPVPEDLSRRFMAYLSQGGKVLALASSFTLPGFRVTSKSPLQDTVQSLVFCKADGSLLRLSILSSGCVYEEGPGEPLDPSKLHGHLDSEDGDRLVVQVPFGIHGGEAVLCQVHLELPPSSPVVQTQEDFNLLKSSNFRRYEVLTEILTTLGLSCDAKQAPALTPLYLLTATEEIWGPLVQWLGKHVDPEGVIRSSKVSLKFISSYTSEIEITPSAIPVVTDTESCSSENFDFEIYRQNLKTKKLGKVILFAEVTPTTMNLLDGLMFEMPQEMGLIAIAVRQTQGKGRGKNAWLSPLGCALSTLLVCIPLRSALGQRIPFVQHLMSLAVVEAVRSIPGYQDINLRVKWPNDIYYSDLMKLGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKEHGAQLQPLRADCLIARTVTVLEKLIDVFQDQGPNGVLPLYYKYWVHSAQQVCLGSAEGPQAWIAGLDDSGFLLVHQEDGDVVTVHPDGNSFDMLRNLIVPKQQ", "length": 827, "header": "tr|F1MJL3-1|A0AAA9SJG9_BOVIN Computationally mapped isoform of Holocarboxylase synthetase OS=Bos taurus OX=9913 GN=HLCS PE=3 SV=4 CANONICAL=A0AAA9SJG9-1" }, "locus": { "chromosome": "1", "start_pos": 149217400, "end_pos": 149031199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057284.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057284.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051848.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051848.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534247", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534247", "resource": "KEGG Pathway" }, { "id": "R-BTA-196780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "resource": "Reactome", "description": "Biotin transport and metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "biotin--[biotin carboxyl-carrier protein] ligase activity", "id": "GO:0004077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004077", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "biotin binding", "id": "GO:0009374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "nuclear matrix", "id": "GO:0016363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "nuclear lamina", "id": "GO:0005652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005652", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" }, { "name": "response to biotin", "id": "GO:0070781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG9" }, { "id": "PS51733", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51733" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BPL/LPL catalytic", "eco_id": "ECO_0000259", "start_pos": 600, "end_pos": 798, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 }, { "start_pos": 732, "end_pos": 734 }, { "start_pos": 749, "end_pos": 751 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ67-1", "uniprot_ac": "A0AAA9SJ67", "uniprot_id": "A0AAA9SJ67_BOVIN", "mass": { "chemical_mass": 128480.0, "monoisotopic_mass": 128480.0 }, "refseq": {}, "gene_names": [ { "name": "LARP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ] } ], "protein_names": [ { "name": "La ribonucleoprotein 1, translational regulator", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LARP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67", "locus": { "chromosome": "7", "start_pos": 66011409, "end_pos": 65922019, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008443", "url": "https://www.ensembl.org/id/ENSBTAG00000008443" } ] } } ], "crossref": [ { "id": "A0AAA9SJ67", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ67", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR006607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22792", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22792", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22792:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22792:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S8H0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8H0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8H0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWRVLASGRPPPPYPEPAFQEAPMPSCPGRRPGRKDSVALAAARQEGDHRCQGEAISLPSSAAVAEDHGGLVRKKPLPPPEGKGEPGANDVGGGEPDGGTRRPRPPCAKQHREGTGQLERESPRPPQPPGAEGLAVSDGEEGGGGEPGAGGGAAGVAGAGRRDFVEAPPPKVNPWTKNALPPVLATVNGQSPPEHSAPAKVVRAAVPKQRKGGKVGDFGDAINWPTPGEIAHKSVQPQAHKSQPARKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLVSRPTRPPEPRHTPTNRGEIKGSEPVTYVPVAPPTPAWQPETKSEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGAEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPMTLIASFHRVQALTTDISLIFAALKDSKVVEIVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEEPRFVHSTTLPQHLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKTPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPAAAGGGSGEGRKRCPSQSSSRPTTSQPPTPPTGQPIREDAKWTSQHSDSQTLGK", "length": 1145, "header": "tr|A0AAA9SJ67-1|A0AAA9SJ67_BOVIN Isoform 1 of La ribonucleoprotein 1, translational regulator OS=Bos taurus OX=9913 GN=LARP1 PE=3 SV=1 CANONICAL=A0AAA9SJ67-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8H0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67/entry#A0AAA9S8H0-1", "sequence": { "sequence": "MATQVEPLLPGGAPLLQAEDHGGLVRKKPLPPPEGKGEPGANDVGGGEPDGGTRRPRPPCAKQHREGTGQLERESPRPPQPPGAEGLAVSDGEEGGGGEPGAGGGAAGVAGAGRRDFVEAPPPKVNPWTKNALPPVLATVNGQSPPGTQVLDLGTVDGKKTEEACTHSSHASGVTQHSAPAKVVRAAVPKQRKGGKVGDFGDAINWPTPGEIAHKSVQPQAHKSQPARKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLVSRPTRPPEPRHTPTNRGEIKGSEPVTYVPVAPPTPAWQPETKSEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGAEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPMTLIASFHRVQALTTDISLIFAALKDSKVVEIVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEEPRFVHSTTLPQHLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKTPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPAAAGGGSGEGRKRCPSQSSSRPTTSQPPTPPTGQPIREDAKWTSQHSDSQTLGK", "length": 1126, "header": "tr|A0AAA9S8H0-1|A0AAA9SJ67_BOVIN Computationally mapped isoform of La ribonucleoprotein 1, translational regulator OS=Bos taurus OX=9913 GN=LARP1 PE=3 SV=1 CANONICAL=A0AAA9SJ67-1" }, "locus": { "chromosome": "7", "start_pos": 66010405, "end_pos": 65952521, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120383.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120383.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078452.1" } ] } }, { "isoform_ac": "A0AAA9S9D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67/entry#A0AAA9S9D9-1", "sequence": { "sequence": "MSAGRLSLPPHPHWGREHSAPAKVVRAAVPKQRKGGKVGDFGDAINWPTPGEIAHKSVQPQAHKSQPARKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLVSRPTRPPEPRHTPTNRGEIKGSEPVTYVPVAPPTPAWQPETKSEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGAEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPMTLIASFHRVQALTTDISLIFAALKDSKVVEIVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEEPRFVHSTTLPQHLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKTPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPAAAGGGSGEGRKRCPSQSSSRPTTSQPPTPPTGQPIREDAKWTSQHSDSQTLGK", "length": 967, "header": "tr|A0AAA9S9D9-1|A0AAA9SJ67_BOVIN Computationally mapped isoform of La ribonucleoprotein 1, translational regulator OS=Bos taurus OX=9913 GN=LARP1 PE=3 SV=2 CANONICAL=A0AAA9SJ67-1" }, "locus": { "chromosome": "7", "start_pos": 66010405, "end_pos": 65985356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098477.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098477.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082692.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082692.2" } ] } }, { "isoform_ac": "A0AAA9SJ67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67/entry#A0AAA9SJ67-1", "sequence": { "sequence": "MSWRVLASGRPPPPYPEPAFQEAPMPSCPGRRPGRKDSVALAAARQEGDHRCQGEAISLPSSAAVAEDHGGLVRKKPLPPPEGKGEPGANDVGGGEPDGGTRRPRPPCAKQHREGTGQLERESPRPPQPPGAEGLAVSDGEEGGGGEPGAGGGAAGVAGAGRRDFVEAPPPKVNPWTKNALPPVLATVNGQSPPEHSAPAKVVRAAVPKQRKGGKVGDFGDAINWPTPGEIAHKSVQPQAHKSQPARKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLVSRPTRPPEPRHTPTNRGEIKGSEPVTYVPVAPPTPAWQPETKSEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGAEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPMTLIASFHRVQALTTDISLIFAALKDSKVVEIVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEEPRFVHSTTLPQHLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKTPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPAAAGGGSGEGRKRCPSQSSSRPTTSQPPTPPTGQPIREDAKWTSQHSDSQTLGK", "length": 1145, "header": "tr|A0AAA9SJ67-1|A0AAA9SJ67_BOVIN Isoform 1 of La ribonucleoprotein 1, translational regulator OS=Bos taurus OX=9913 GN=LARP1 PE=3 SV=1 CANONICAL=A0AAA9SJ67-1" }, "locus": { "chromosome": "7", "start_pos": 66010405, "end_pos": 65922133, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105923.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105923.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086302.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1120, "start_aa": "Thr", "end_pos": 1120, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1120", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 352, "start_aa": "Thr", "end_pos": 352, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr352", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 577, "start_aa": "Thr", "end_pos": 577, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr577", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 907, "start_aa": "Thr", "end_pos": 907, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr907", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "mRNA stabilization", "id": "GO:0048255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "cellular response to rapamycin", "id": "GO:0072752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072752", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "positive regulation of macroautophagy", "id": "GO:0016239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016239", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "negative regulation of translational initiation", "id": "GO:0045947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045947", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "response to amino acid starvation", "id": "GO:1990928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990928", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "TORC1 signaling", "id": "GO:0038202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "positive regulation of viral genome replication", "id": "GO:0045070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "positive regulation of translational initiation", "id": "GO:0045948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045948", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "RNA cap binding", "id": "GO:0000339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "eukaryotic initiation factor 4E binding", "id": "GO:0008190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008190", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "translation activator activity", "id": "GO:0008494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "RNA 7-methylguanosine cap binding", "id": "GO:0000340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000340", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "mRNA 5'-UTR binding", "id": "GO:0048027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" }, { "name": "TORC1 complex", "id": "GO:0031931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031931", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 715, "end_pos": 717, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ67" }, { "id": "PS50961", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50961" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HTH La-type RNA-binding", "eco_id": "ECO_0000259", "start_pos": 446, "end_pos": 536, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 352, 577, 907, 1120 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 431, "end_pos": 433 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 715, "end_pos": 717 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKB6-1", "uniprot_ac": "A0AAA9SKB6", "uniprot_id": "A0AAA9SKB6_BOVIN", "mass": { "chemical_mass": 43820.0, "monoisotopic_mass": 43820.0 }, "refseq": {}, "gene_names": [ { "name": "HAUS7", "type": "recommended", "evidence": [ { "id": "A0AAA9SKB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ] } ], "protein_names": [ { "name": "HAUS augmin like complex subunit 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SKB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6", "locus": { "chromosome": "X", "start_pos": 36676282, "end_pos": 36722856, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014095", "url": "https://www.ensembl.org/id/ENSBTAG00000014095" } ] } } ], "crossref": [ { "id": "A0AAA9SKB6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14352:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14352:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SE91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QXC3", "url": "https://www.uniprot.org/uniprotkb/F6QXC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QXC3-1", "url": "https://www.uniprot.org/uniprotkb/F6QXC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELGPVGGGGSGGGYEGESDDSSFQAAVEVFAKLKDLNCPFLDGLYITEPKTIQELLCSPSKYRLEILEWMCTRVCPSWLDRFSSLKGVSAEVKIQAEMVKLGHELMLCGLDDQELLKGRACAQKQLHFMDQLLDVVHSLSVGDSSCPSAEECFEDTREKTEGLLGELFSSPCLQTLLRPKCESWPVDMQPLLDKQSDDRQGASPLVKLEEEKVAKLARQLQESASKLQALQVECFAQQGATVGSAHASTLDQKLRLVISDFHQLVMAFLQVYDGELGEYCQRPGPYLHPCGPIIQAVYQTLTSCSQLLKAAVEVTSTSVKAVHMANQQHDEQICWGNNSSVMSLAIGFPVSVKTITVSKRPRAETFVFLDLEAIGLPSVDPENAELSLFAVHQSSLED", "length": 400, "header": "tr|A0AAA9SKB6-1|A0AAA9SKB6_BOVIN Isoform 1 of HAUS augmin like complex subunit 7 OS=Bos taurus OX=9913 GN=HAUS7 PE=4 SV=1 CANONICAL=A0AAA9SKB6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6/entry#A0AAA9SE91-1", "sequence": { "sequence": "MAELGPVGGGGSGGGYEGESDDSSFQAAVEVFAKLKDLNCPFLDGLYITEPKTIQELLCSPSKYRLEILEWMCTRVCPSWLDRFSSLKGVSAEVKIQEMVKLGHELMLCGLDDQELLKGRACAQKQLHFMDQLLDVVHSLSVGDSSCPSAEECFEDTREKTEGLLGELFSSPCLQTLLRPKCESWPVDMQPLLDKQSDDRQGASPLVKLEEEKVAKLARQLQESASKLQALQVECFAQQGATVGSAHASTLDQKLRLVISDFHQLVMAFLQVYDGELGEYCQRPGPYLHPCGPIIQAVYQTLTSCSQLLKAAVEVTSTSVKAVHMANQQHDEQICWGNNSSVMSLGVLEWVTISFSNKQRRY", "length": 362, "header": "tr|A0AAA9SE91-1|A0AAA9SKB6_BOVIN Computationally mapped isoform of HAUS augmin like complex subunit 7 OS=Bos taurus OX=9913 GN=HAUS7 PE=4 SV=1 CANONICAL=A0AAA9SKB6-1" }, "locus": { "chromosome": "X", "start_pos": 36703200, "end_pos": 36676349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108117.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108117.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082152.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082152.1" } ] } }, { "isoform_ac": "A0AAA9SKB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6/entry#A0AAA9SKB6-1", "sequence": { "sequence": "MAELGPVGGGGSGGGYEGESDDSSFQAAVEVFAKLKDLNCPFLDGLYITEPKTIQELLCSPSKYRLEILEWMCTRVCPSWLDRFSSLKGVSAEVKIQAEMVKLGHELMLCGLDDQELLKGRACAQKQLHFMDQLLDVVHSLSVGDSSCPSAEECFEDTREKTEGLLGELFSSPCLQTLLRPKCESWPVDMQPLLDKQSDDRQGASPLVKLEEEKVAKLARQLQESASKLQALQVECFAQQGATVGSAHASTLDQKLRLVISDFHQLVMAFLQVYDGELGEYCQRPGPYLHPCGPIIQAVYQTLTSCSQLLKAAVEVTSTSVKAVHMANQQHDEQICWGNNSSVMSLAIGFPVSVKTITVSKRPRAETFVFLDLEAIGLPSVDPENAELSLFAVHQSSLED", "length": 400, "header": "tr|A0AAA9SKB6-1|A0AAA9SKB6_BOVIN Isoform 1 of HAUS augmin like complex subunit 7 OS=Bos taurus OX=9913 GN=HAUS7 PE=4 SV=1 CANONICAL=A0AAA9SKB6-1" }, "locus": { "chromosome": "X", "start_pos": 36703200, "end_pos": 36683822, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084314.1" } ] } }, { "isoform_ac": "A0AAA9SSH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6/entry#A0AAA9SSH3-1", "sequence": { "sequence": "MIARDAVMGSKKHWRSGERTLGILWTVGIPGEGASGRWAGGGWKAASVAWGQKGPRWLMWLSRGSKDLNCPFLDGLYITEPKTIQELLCSPSKYRLEILEWMCTRVCPSWLDRFSSLKGVSAEVKIQAEMVKLGHELMLCGLDDQELLKGRACAQKQLHFMDQLLDVVHSLSVGDSSCPSAEECFEDTREKTEGLLGELFSSPCLQTLLRPKCESWPVDMQPLLDKQSDDRQGASPLVKLEEEKVAKLARQLQESASKLQALQVECFAQQGATVGSAHASTLDQKLRLVISDFHQLVMAFLQVYDGELGEYCQRPGPYLHPCGPIIQAVYQTLTSCSQLLKAAVEVTSTSVKAVHMANQQHDEQICWGNNSSVMSLATKMEELTQQYKTFSNCLHKGPQ", "length": 399, "header": "tr|A0AAA9SSH3-1|A0AAA9SSH3_BOVIN Computationally mapped isoform of HAUS augmin like complex subunit 7 OS=Bos taurus OX=9913 GN=HAUS7 PE=4 SV=2 CANONICAL=A0AAA9SKB6-1" }, "locus": { "chromosome": "X", "start_pos": 36708501, "end_pos": 36686443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092334.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092334.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086940.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086940.2" } ] } }, { "isoform_ac": "F6QXC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6/entry#F6QXC3-1", "sequence": { "sequence": "MAELGPVGGGGSGGGYEGESDDSSFQAAVEVFAKLKDLNCPFLDGLYITEPKTIQELLCSPSKYRLEILEWMCTRVCPSWLDRFSSLKGVSAEVKIQAEMVKLGHELMLCGLDDQELLKGRACAQKQLHFMDQLLDVVHSLSVGDSSCPRGTQAHPTEDGYLSCPCSAEECFEDTREKTEGLLGELFSSPCLQTLLRPKCESWPVDMQPLLDKQSDDRQGASPLVKLEEEKVAKLARQLQESASKLQALQVECFAQQGATVGSAHASTLDQKLRLVISDFHQLVMAFLQVYDGELGEYCQRPGPYLHPCGPIIQAVYQTLTSCSQLLKAAVEVTSTSVKAVHMANQQHDEQICWGNNSSVMSLATKMEELTQQYKTFSNCLHKGPQ", "length": 386, "header": "tr|F6QXC3-1|F6QXC3_BOVIN Computationally mapped isoform of HAUS augmin like complex subunit 7 OS=Bos taurus OX=9913 GN=HAUS7 PE=4 SV=1 CANONICAL=A0AAA9SKB6-1" }, "locus": { "chromosome": "X", "start_pos": 36703200, "end_pos": 36686443, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018739.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018739.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018739.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018739.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "pmid": "" }, { "name": "HAUS complex", "id": "GO:0070652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070652", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "pmid": "" }, { "name": "mitotic spindle microtubule", "id": "GO:1990498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990498", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "thioesterase binding", "id": "GO:0031996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031996", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "centrosome cycle", "id": "GO:0007098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007098", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "pmid": "" }, { "name": "spindle assembly", "id": "GO:0051225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 339, "end_pos": 341 }, { "start_pos": 340, "end_pos": 342 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIC7-1", "uniprot_ac": "A0AAA9SIC7", "uniprot_id": "A0AAA9SIC7_BOVIN", "mass": { "chemical_mass": 117435.0, "monoisotopic_mass": 117435.0 }, "refseq": { "ac": "XP_002695865", "name": "cytospin-B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695865" }, "gene_names": [ { "name": "SPECC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SIC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7" } ] }, { "name": "SPECC1", "type": "synonym", "evidence": [ { "id": "XP_002695865", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695865" } ] } ], "protein_names": [ { "name": "Sperm antigen with calponin homology and coiled-coil domains 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SIC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7/entry#names_and_taxonomy" } ] }, { "name": "cytospin-B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002695865", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695865" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPECC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7", "locus": { "chromosome": "19", "start_pos": 33521157, "end_pos": 33725875, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000928", "url": "https://www.ensembl.org/id/ENSBTAG00000000928" } ] } } ], "crossref": [ { "id": "A0AAA9SIC7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000928", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000928", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506538", "url": "https://www.ncbi.nlm.nih.gov/gene/506538", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050540", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050540", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506538", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506538", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23167:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23167:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695865", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695865", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEN2", "url": "https://www.uniprot.org/uniprotkb/F1MEN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEN2-1", "url": "https://www.uniprot.org/uniprotkb/F1MEN2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEGLPGTNMRSAAKPWSPVTRAGSHGVDRPRPLPVPSPGMKSSKSSTSLAFESRLSKLKRASSEDTLNKPGAAVASGAAARLKKTSTSGAISELTESRLRGPSGSVTATKRTGIPAPRELAVTVSRDRTVPRGPSNSRKVTTSPTSSSTPTPTKHVRAAPPRPRPEHEGAEKAVLESQVRELLAEAKEKDSEINRLRSELKKWMEKRTQDSEGGDALDSSVDGASVLPGDSEPLIRALEEKNKSFQKELAELEEENRALKEKLTYFEHSPDSEGGASHTGDSSCPTSVTQESSFGSPTGNEALSEIDVYRKNPHEGALRTSGSSSSDVTKASLSPDASDFEHIPADTLGPLSPAGSLVKSSKCSAAGSSPNTASELSLASLAEKIHRMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLADEKTLLETSFHQHRERAEQLSQENEKLMTLLQERVKGEEPGAQEGKILELEQKCTEILEQGRFEREKLLSIQQQLTCRLRAVEEEHRSALELVRHLQEVNGELTTRLELEQHSGGPTAEIPAARQLPVEGLQVENGSLQASLENEEQKTGGASPLGPMAEGCDVQEMLTVARAEKDQLEQSCSELRQELLKAHGEVKRVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVMKLEEQKSDLERQLKTLTKQIKDETEEWRRFQADLQTAVVVANDIKVEAQQELRAVKRRLLEEEEKNARLQKALGDAQARGRPVKEEPEPSEADAPGRWPSAYVNRTPPTPSESVTTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTPPAAAVSPMQRHSAFSSARPASKGEIQRLDLPDLPLSDLLKGRAEDLKPNPYLRKSPSLESLSRPPSLGFGGSRLLGTSPAGWKPQSKLSVERRDPLAALAREYGGSKRNALLRWCQRKTEGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSELLHTDRPDWQSVMQYVAQIYKYFET", "length": 1068, "header": "tr|A0AAA9SIC7-1|A0AAA9SIC7_BOVIN Isoform 1 of Sperm antigen with calponin homology and coiled-coil domains 1 OS=Bos taurus OX=9913 GN=SPECC1 PE=3 SV=1 CANONICAL=A0AAA9SIC7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7/entry#A0AAA9SEC9-1", "sequence": { "sequence": "MRSAAKPWSPVTRAGSHGVDRPRPLPVPSPGMKSSKSSTSLAFESRLSKLKRASSEDTLNKPGAAVASGAAARLKKTSTSGAISELTESRLRGPSGSVTATKRTGIPAPRELAVTVSRDRTVPRGPSNSRKVTTSPTSSSTPTPTKHVRAAPPRPRPEHEGAEKAVLESQVRELLAEAKEKDSEINRLRSELKKWMEKRTQDSEGGDALDSSVDGASVLPGDSEPLIRALEEKNKSFQKELAELEEENRALKEKLTYFEHSPDSEGGASHTGDSSCPTSVTQESSFGSPTGNEALSEIDVYRKNPHEGALRTSGSSSSDVTKASLSPDASDFEHIPADTLGPLSPAGSLVKSSKCSAAGSSPNTASELSLASLAEKIHRMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLADEKTLLETSFHQHRERAEQLSQENEKLMTLLQERVKGEEPGAQEGKILELEQKCTEILEQGRFEREKLLSIQQQLTCRLRAVEEEHRSALELVRHLQEVNGELTTRLELEQHSGGPTAEIPAARQLPVEGLQVENGSLQASLENEEQKTGGASPLGPMAEGCDVQEMLTVARAEKDQLEQSCSELRQELLKAHGEVKRVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVMKLEEQKSDLERQLKTLTKQIKDETEEWRRFQADLQTAVVVANDIKVEAQQELRAVKRRLLEEEEKNARLQKALGDAQARGRPVKEEPEPSEADAPGRWPSAYVNRTPPTPSESVTTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTPPAAAVSPMQRHSAFSSARPASKGEIQRLDLPDLPLSDLLKGRAEDLKPNPYLRKSPSLESLSRPPSLGFGGSRLLGTSPAGWKPQSKLSVERRDPLAALAREYGGSKRNALLRWCQRKTEGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSELLHTDRPDWQSVMQYVAQIYKYFET", "length": 1059, "header": "tr|A0AAA9SEC9-1|A0AAA9SIC7_BOVIN Computationally mapped isoform of Sperm antigen with calponin homology and coiled-coil domains 1 OS=Bos taurus OX=9913 GN=SPECC1 PE=3 SV=2 CANONICAL=A0AAA9SIC7-1" }, "locus": { "chromosome": "19", "start_pos": 33669141, "end_pos": 33522161, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089066.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089066.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082200.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082200.2" } ] } }, { "isoform_ac": "A0AAA9SIC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7/entry#A0AAA9SIC7-1", "sequence": { "sequence": "MEEGLPGTNMRSAAKPWSPVTRAGSHGVDRPRPLPVPSPGMKSSKSSTSLAFESRLSKLKRASSEDTLNKPGAAVASGAAARLKKTSTSGAISELTESRLRGPSGSVTATKRTGIPAPRELAVTVSRDRTVPRGPSNSRKVTTSPTSSSTPTPTKHVRAAPPRPRPEHEGAEKAVLESQVRELLAEAKEKDSEINRLRSELKKWMEKRTQDSEGGDALDSSVDGASVLPGDSEPLIRALEEKNKSFQKELAELEEENRALKEKLTYFEHSPDSEGGASHTGDSSCPTSVTQESSFGSPTGNEALSEIDVYRKNPHEGALRTSGSSSSDVTKASLSPDASDFEHIPADTLGPLSPAGSLVKSSKCSAAGSSPNTASELSLASLAEKIHRMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLADEKTLLETSFHQHRERAEQLSQENEKLMTLLQERVKGEEPGAQEGKILELEQKCTEILEQGRFEREKLLSIQQQLTCRLRAVEEEHRSALELVRHLQEVNGELTTRLELEQHSGGPTAEIPAARQLPVEGLQVENGSLQASLENEEQKTGGASPLGPMAEGCDVQEMLTVARAEKDQLEQSCSELRQELLKAHGEVKRVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVMKLEEQKSDLERQLKTLTKQIKDETEEWRRFQADLQTAVVVANDIKVEAQQELRAVKRRLLEEEEKNARLQKALGDAQARGRPVKEEPEPSEADAPGRWPSAYVNRTPPTPSESVTTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTPPAAAVSPMQRHSAFSSARPASKGEIQRLDLPDLPLSDLLKGRAEDLKPNPYLRKSPSLESLSRPPSLGFGGSRLLGTSPAGWKPQSKLSVERRDPLAALAREYGGSKRNALLRWCQRKTEGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSELLHTDRPDWQSVMQYVAQIYKYFET", "length": 1068, "header": "tr|A0AAA9SIC7-1|A0AAA9SIC7_BOVIN Isoform 1 of Sperm antigen with calponin homology and coiled-coil domains 1 OS=Bos taurus OX=9913 GN=SPECC1 PE=3 SV=1 CANONICAL=A0AAA9SIC7-1" }, "locus": { "chromosome": "19", "start_pos": 33681366, "end_pos": 33522161, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127156.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127156.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083500.1" } ] } }, { "isoform_ac": "A0AAA9TXA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7/entry#A0AAA9TXA6-1", "sequence": { "sequence": "MGNHSGRPEDPEAGSVTATKRTGIPAPRELAVTVSRDRTVPRGPSNSRKVTTSPTSSSTPTPTKHVRAAPPRPRPEHEGAEKAVLESQVRELLAEAKEKDSEINRLRSELKKWMEKRTQDSEGGDALDSSVDGASVLPGDSEPLIRALEEKNKSFQKELAELEEENRALKEKLTYFEHSPDSEGGASHTGDSSCPTSVTQESSFGSPTGNEALSEIDVYRKNPHEGALRTSGSSSSDVTKASLSPDASDFEHIPADTLGPLSPAGSLVKSSKCSAAGSSPNTASELSLASLAEKIHRMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLADEKTLLETSFHQHRERAEQLSQENEKLMTLLQERVKGEEPGAQEGKILELEQKCTEILEQGRFEREKLLSIQQQLTCRLRAVEEEHRSALELVRHLQEVNGELTTRLELEQHSGGPTAEIPAARQLPVEGLQVENGSLQASLENEEQKTGGASPLGPMAEGCDVQEMLTVARAEKDQLEQSCSELRQELLKAHGEVKRVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVMKLEEQKSDLERQLKTLTKQIKDETEEWRRFQADLQTAVVVANDIKVEAQQELRAVKRRLLEEEEKNARLQKALGDAQARGRPVKEEPEPSEADAPGRWPSAYVNRTPPTPSESVTTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTPPAAAVSPMQRHSAFSSARPASKGEIQRLDLPDLPLSDLLKGRAEDLKPNPYLRKSPSLESLSRPPSLGFGGSRLLGTSPAGWKPQSKLSVERRDPLAALAREYGGSKRNALLRWCQRKTEGYAHLLLLVLLLPVTGACVTRGLTQAVAYFPCWQKRNLLLAFEAAESVGIKPSLELSELLHTDRPDWQSVMQYVAQIYKYFET", "length": 969, "header": "tr|A0AAA9TXA6-1|A0AAA9TXA6_BOVIN Computationally mapped isoform of Sperm antigen with calponin homology and coiled-coil domains 1 OS=Bos taurus OX=9913 GN=SPECC1 PE=4 SV=1 CANONICAL=A0AAA9SIC7-1" }, "locus": { "chromosome": "19", "start_pos": 33638517, "end_pos": 33522161, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090256.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090256.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102970.1" } ] } }, { "isoform_ac": "F1MEN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7/entry#F1MEN2-1", "sequence": { "sequence": "MVMWQIPVGGWLIRELMGSLVEGEGLPGTNMRSAAKPWSPVTRAGSHGVDRPRPLPVPSPGMKSSKSSTSLAFESRLSKLKRASSEDTLNKPGAAVASGAAARLKKTSTSGAISELTESRLRGPSGSVTATKRTGIPAPRELAVTVSRDRTVPRGPSNSRKVTTSPTSSSTPTPTKHVRAAPPRPRPEHEGAEKAVLESQVRELLAEAKEKDSEINRLRSELKKWMEKRTQDSEGGDALDSSVDGASVLPGDSEPLIRALEEKNKSFQKELAELEEENRALKEKLTYFEHSPDSEGGASHTGDSSCPTSVTQESSFGSPTGNEALSEIDVYRKNPHEGALRTSGSSSSDVTKASLSPDASDFEHIPADTLGPLSPAGSLVKSSKCSAAGSSPNTASELSLASLAEKIHRMEENQHSTAEELQATLQELSDQQQMVQELTAENEKLADEKTLLETSFHQHRERAEQLSQENEKLMTLLQERVKGEEPGAQEGKILELEQKCTEILEQGRFEREKLLSIQQQLTCRLRAVEEEHRSALELVRHLQEVNGELTTRLELEQHSGGPTAEIPAARQLPVEGLQVENGSLQASLENEEQKTGGASPLGPMAEGCDVQEMLTVARAEKDQLEQSCSELRQELLKAHGEVKRVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVMKLEEQKSDLERQLKTLTKQIKDETEEWRRFQADLQTAVVVANDIKVEAQQELRAVKRRLLEEEEKNARLQKALGDAQARGRPVKEEPEPSEADAPGRWPSAYVNRTPPTPSESVTTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTPPAAAVSPMQRHSAFSSARPASKGEIQRLDLPDLPLSDLLKGRAEDLKPNPYLRKSPSLESLSRPPSLGFGGSRLLGTSPAGWKPQSKLSVERRDPLAALAREYGGSKRNALLRWCQRKTEGYAVMLLLLLLSHFSRVRLCATP", "length": 1021, "header": "tr|F1MEN2-1|A0AAA9SIC7_BOVIN Computationally mapped isoform of Sperm antigen with calponin homology and coiled-coil domains 1 OS=Bos taurus OX=9913 GN=SPECC1 PE=3 SV=4 CANONICAL=A0AAA9SIC7-1" }, "locus": { "chromosome": "19", "start_pos": 33697249, "end_pos": 33547775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035035.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035035.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034915.6", "url": "https://www.ensembl.org/id/ENSBTAP00000034915.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 542, "start_aa": "Thr", "end_pos": 542, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr542", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 812, "start_aa": "Thr", "end_pos": 812, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr812", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506538", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506538", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 560, "end_pos": 562, "annotation": "n_glycosylation_sequon" }, { "start_pos": 807, "end_pos": 809, "annotation": "n_glycosylation_sequon" }, { "start_pos": 838, "end_pos": 840, "annotation": "n_glycosylation_sequon" }, { "start_pos": 986, "end_pos": 988, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC7" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 962, "end_pos": 1067, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 542, 812 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 243, "end_pos": 245 }, { "start_pos": 560, "end_pos": 562 }, { "start_pos": 807, "end_pos": 809 }, { "start_pos": 838, "end_pos": 840 }, { "start_pos": 986, "end_pos": 988 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIC9-1", "uniprot_ac": "A0AAA9SIC9", "uniprot_id": "A0AAA9SIC9_BOVIN", "mass": { "chemical_mass": 27490.0, "monoisotopic_mass": 27490.0 }, "refseq": { "ac": "XP_010814280", "name": "tumor necrosis factor ligand superfamily member 12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814280" }, "gene_names": [ { "name": "TNFSF12", "type": "recommended", "evidence": [ { "id": "A0AAA9SIC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ] }, { "name": "TNFSF12", "type": "synonym", "evidence": [ { "id": "XP_010814280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814280" } ] }, { "name": "TWEAK", "type": "synonym", "evidence": [ { "id": "XP_010814280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814280" } ] } ], "protein_names": [ { "name": "TNF superfamily member 12", "type": "synonym", "evidence": [ { "id": "A0AAA9SIC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9/entry#names_and_taxonomy" } ] }, { "name": "tumor necrosis factor ligand superfamily member 12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010814280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814280" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFSF12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9", "locus": { "chromosome": "19", "start_pos": 27291150, "end_pos": 27282474, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031725", "url": "https://www.ensembl.org/id/ENSBTAG00000031725" } ] } } ], "crossref": [ { "id": "A0AAA9SIC9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIC9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031725", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031725", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00184", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00184", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100551513", "url": "https://www.ncbi.nlm.nih.gov/gene/100551513", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MX43", "url": "https://www.orthodb.org/?gene=F1MX43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15151:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15151:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5668541", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5676594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010814280", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814280", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX43", "url": "https://www.uniprot.org/uniprotkb/F1MX43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX43-1", "url": "https://www.uniprot.org/uniprotkb/F1MX43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRRIQRRRERRGEPGTALLAPLVLGLGLVLACLGLLLAVVSLGSRASLFAQQEPSQRDLVAEEDPDPLDLNPQPEESQDAVPFLKLVRPRRNASKGQKPRARRAVAAHYEVRPRPGQDGAQAGVDGTVSGWEEAKINSSNPLRYDCQTGQFTVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDDTLALRCLEEFSATAASSPGPQLRLCQVSGLLRLRRGSSLRIRTLPQTQLKAAPFLTYFGLFQVH", "length": 249, "header": "tr|A0AAA9SIC9-1|A0AAA9SIC9_BOVIN Isoform 1 of TNF superfamily member 12 OS=Bos taurus OX=9913 GN=TNFSF12 PE=3 SV=1 CANONICAL=A0AAA9SIC9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9/entry#A0AAA9SGW1-1", "sequence": { "sequence": "QSRSGRTRPAALAAVFPPRHRHPGRVEFLLFQPSLPLSRRPAARVQRAQPHTPARPLHTHTHIAPLFRAREEPSQRDLVAEEDPDPLDLNPQPEESQDAVPFLKLVRPRRNASKGQKPRARRAVAAHYEVRPRPGQDGAQAGVDGTVSGWEEAKINSSNPLRYDCQTGQFTVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDDTLALRCLEEFSATAASSPGPQLRLCQVSGLLRLRRGSSLRIRTLPQTQLKAAPFLTYFGLFQVH", "length": 266, "header": "tr|A0AAA9SGW1-1|A0AAA9SIC9_BOVIN Computationally mapped isoform of TNF superfamily member 12 OS=Bos taurus OX=9913 GN=TNFSF12 PE=3 SV=1 CANONICAL=A0AAA9SIC9-1" }, "locus": { "chromosome": "19", "start_pos": 27290667, "end_pos": 27282912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090176.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090176.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085432.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085432.1" } ] } }, { "isoform_ac": "A0AAA9SIC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9/entry#A0AAA9SIC9-1", "sequence": { "sequence": "MATRRIQRRRERRGEPGTALLAPLVLGLGLVLACLGLLLAVVSLGSRASLFAQQEPSQRDLVAEEDPDPLDLNPQPEESQDAVPFLKLVRPRRNASKGQKPRARRAVAAHYEVRPRPGQDGAQAGVDGTVSGWEEAKINSSNPLRYDCQTGQFTVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDDTLALRCLEEFSATAASSPGPQLRLCQVSGLLRLRRGSSLRIRTLPQTQLKAAPFLTYFGLFQVH", "length": 249, "header": "tr|A0AAA9SIC9-1|A0AAA9SIC9_BOVIN Isoform 1 of TNF superfamily member 12 OS=Bos taurus OX=9913 GN=TNFSF12 PE=3 SV=1 CANONICAL=A0AAA9SIC9-1" }, "locus": { "chromosome": "19", "start_pos": 27290667, "end_pos": 27283387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085995.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085995.1" } ] } }, { "isoform_ac": "A0AAA9SUC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9/entry#A0AAA9SUC3-1", "sequence": { "sequence": "MATRRIQRRRERRGEPGTALLAPLVLGLGLVLACLGLLLAVVSLGSRASLFAQEPSQRDLVAEEDPDPLDLNPQPEESQDAVPFLKLVRPRRNASKGQKPRARRAVAAHYEVRPRPGQDGAQAGAL", "length": 126, "header": "tr|A0AAA9SUC3-1|A0AAA9SUC3_BOVIN Computationally mapped isoform of TNF superfamily member 12 OS=Bos taurus OX=9913 GN=TNFSF12 PE=4 SV=1 CANONICAL=A0AAA9SIC9-1" }, "locus": { "chromosome": "19", "start_pos": 27290426, "end_pos": 27283387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127943.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127943.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087747.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087747.1" } ] } }, { "isoform_ac": "A0AAA9TWL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9/entry#A0AAA9TWL0-1", "sequence": { "sequence": "MATRRIQRRRERRGEPGTALLAPLVLGLGLVLACLGLLLAVVSLGSRASLFAQEPSQRDLVAEEDPDPLDLNPQPEESQDAVPFLKLVRPRRNASKGQKPRARRAVAAHYEVRPRPGQDGAQAGEAPIPLTALAFWTRDPP", "length": 141, "header": "tr|A0AAA9TWL0-1|A0AAA9TWL0_BOVIN Computationally mapped isoform of TNF superfamily member 12 OS=Bos taurus OX=9913 GN=TNFSF12 PE=4 SV=1 CANONICAL=A0AAA9SIC9-1" }, "locus": { "chromosome": "19", "start_pos": 27285239, "end_pos": 27283387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126891.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126891.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100983.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100983.1" } ] } }, { "isoform_ac": "F1MX43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9/entry#F1MX43-1", "sequence": { "sequence": "MATRRIQRRRERRGEPGTALLAPLVLGLGLVLACLGLLLAVVSLGSRASLFAQQEPSQRDLVAEEDPDPLDLNPQPEESQDAVPFLKLVRPRRNVRPRPGQDGAQAGVDGTVSGWEEAKINSSNPLRYDCQTGQFTVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDDTLALRCLEEFSATAASSPGPQLRLCQVSGLLRLRRGSSLRIRTLPQTQLKAAPFLTYFGLFQVH", "length": 231, "header": "tr|F1MX43-1|F1MX43_BOVIN Computationally mapped isoform of TNF superfamily member 12 OS=Bos taurus OX=9913 GN=TNFSF12 PE=3 SV=3 CANONICAL=A0AAA9SIC9-1" }, "locus": { "chromosome": "19", "start_pos": 27290667, "end_pos": 27283387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045584.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045584.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042963.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042963.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5668541", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668541", "resource": "Reactome", "description": "TNFR2 non-canonical NF-kB pathway" }, { "id": "R-BTA-5676594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5676594", "resource": "Reactome", "description": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" }, { "name": "positive regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001238", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC9" }, { "id": "PS50049", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50049" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THD", "eco_id": "ECO_0000259", "start_pos": 107, "end_pos": 248, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 139, "end_pos": 141 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJH9-1", "uniprot_ac": "A0AAA9SJH9", "uniprot_id": "A0AAA9SJH9_BOVIN", "mass": { "chemical_mass": 77081.0, "monoisotopic_mass": 77081.0 }, "refseq": { "ac": "XP_005206219", "name": "calcium-binding and coiled-coil domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206219" }, "gene_names": [ { "name": "CALCOCO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ] }, { "name": "CALCOCO1", "type": "synonym", "evidence": [ { "id": "XP_005206219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206219" } ] } ], "protein_names": [ { "name": "Calcium-binding and coiled-coil domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#names_and_taxonomy" } ] }, { "name": "calcium-binding and coiled-coil domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005206219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206219" } ] } ], "function": [ { "annotation": "Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MRI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRI3#function" }, { "database": "UniProtKB", "id": "ARBA00045799", "url": "https://www.uniprot.org/uniprotkb/ARBA00045799#function" }, { "database": "UniProtKB", "id": "F1N037", "url": "https://www.uniprot.org/uniprotkb/F1N037#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ72#function" }, { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9#function" }, { "database": "UniProtKB", "id": "A0AAA9SI38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI38#function" }, { "database": "UniProtKB", "id": "A0ABI0NLL4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLL4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CALCOCO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9", "locus": { "chromosome": "5", "start_pos": 26342671, "end_pos": 26328422, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015016", "url": "https://www.ensembl.org/id/ENSBTAG00000015016" } ] } } ], "crossref": [ { "id": "A0AAA9SJH9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015016", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015016", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21967", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21967", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538675", "url": "https://www.ncbi.nlm.nih.gov/gene/538675", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HNWASND", "url": "https://omabrowser.org/oma/group/HNWASND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MRI3", "url": "https://www.orthodb.org/?gene=A0A3Q1MRI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N037", "url": "https://www.orthodb.org/?gene=F1N037", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31915", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31915", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31915:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31915:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07888", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07888", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17751", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17751", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005206219", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLL4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLL4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N037", "url": "https://www.uniprot.org/uniprotkb/F1N037", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N037-1", "url": "https://www.uniprot.org/uniprotkb/F1N037-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLTEASTGGPATPPWKECPICKERFPAESDKDAMEDHMDGHFFFSTQDPFTFE", "length": 692, "header": "tr|A0AAA9SJH9-1|A0AAA9SJH9_BOVIN Isoform 1 of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=1 CANONICAL=A0AAA9SJH9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#A0A3Q1MRI3-1", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASTVLCRAQIALHPPSPAPMPSPATRCCRSSLTPLGNPLGGGFSGFAVGPLTEASTGGPATPPWKECPICKERFPAESDKDAMEDHMDGHFFFSTQDPFTFE", "length": 734, "header": "tr|A0A3Q1MRI3-1|A0A3Q1MRI3_BOVIN Computationally mapped isoform of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=2 CANONICAL=A0AAA9SJH9-1" }, "locus": { "chromosome": "5", "start_pos": 26341667, "end_pos": 26330611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069806.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069806.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074398.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074398.2" } ] } }, { "isoform_ac": "A0AAA9SI38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#A0AAA9SI38-1", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMARCCRSSLTPLGNPLGGGFSGFAVGPLTEASTGGPATPPWKECPICKERFPAESDKDAMEDHMDGHFFFSTQDPFTFE", "length": 710, "header": "tr|A0AAA9SI38-1|A0AAA9SJH9_BOVIN Computationally mapped isoform of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=1 CANONICAL=A0AAA9SJH9-1" }, "locus": { "chromosome": "5", "start_pos": 26341667, "end_pos": 26330611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095957.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095957.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082206.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082206.1" } ] } }, { "isoform_ac": "A0AAA9SJH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#A0AAA9SJH9-1", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLTEASTGGPATPPWKECPICKERFPAESDKDAMEDHMDGHFFFSTQDPFTFE", "length": 692, "header": "tr|A0AAA9SJH9-1|A0AAA9SJH9_BOVIN Isoform 1 of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=1 CANONICAL=A0AAA9SJH9-1" }, "locus": { "chromosome": "5", "start_pos": 26341667, "end_pos": 26330611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101469.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101469.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082755.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082755.1" } ] } }, { "isoform_ac": "A0AAA9TJ72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#A0AAA9TJ72-1", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQEPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLTEASTGGPATPPWKECPICKERFPAESDKDAMEDHMDGHFFFSTQDPFTFE", "length": 607, "header": "tr|A0AAA9TJ72-1|A0AAA9TJ72_BOVIN Computationally mapped isoform of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=1 CANONICAL=A0AAA9SJH9-1" }, "locus": { "chromosome": "5", "start_pos": 26341667, "end_pos": 26330611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123696.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123696.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098379.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098379.1" } ] } }, { "isoform_ac": "A0ABI0NLL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#A0ABI0NLL4-1", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMAR", "length": 634, "header": "tr|A0ABI0NLL4-1|A0ABI0NLL4_BOVIN Computationally mapped isoform of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=1 CANONICAL=A0AAA9SJH9-1" }, "locus": { "chromosome": "5", "start_pos": 26340518, "end_pos": 26330611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145123.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145123.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105698.1" } ] } }, { "isoform_ac": "F1N037-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9/entry#F1N037-1", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPESVTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEETDGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHGELTEERDILSRQQGDHVARILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQVQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLKEEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWSEDPATEDEEAAVGLSCPAALTDSEDESPEDMRLPPYSLCESGDPGSSPATGPREASPLVVISQPAPIAPQLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASTVLCRAQIALHPPSPAPMPSPATSGFAVGPLTEASTGGPATPPWKECPICKERFPAESDKDAMEDHMDGHFFFSTQDPFTFE", "length": 716, "header": "tr|F1N037-1|F1N037_BOVIN Computationally mapped isoform of Calcium-binding and coiled-coil domain-containing protein 1 OS=Bos taurus OX=9913 GN=CALCOCO1 PE=3 SV=3 CANONICAL=A0AAA9SJH9-1" }, "locus": { "chromosome": "5", "start_pos": 26341667, "end_pos": 26330611, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019992.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019992.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019992.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019992.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 651, "start_aa": "Thr", "end_pos": 651, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr651", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q66HR5-1", "protein_name": "Calcium-binding and coiled-coil domain-containing protein 1", "gene_name": "Calcoco1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEESSLSRAPSRGGVSFLNVARTYVPNTKVECHYTLPPGTTPSASDWIGIFKVEAACVRDYHTFVWSSVPETTTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHGELSEERDILSQQQGEHVARILELEDDIQTMSDKVLMKEVELDRVRDMVKALTREQEKLLGQLKEFQADKEQSEAELQTVREENCHLNTELQEAKGRQEEQGAQVQRLKDKVAHMKDTLGQTQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQEERSQSHMFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWNEDAATEDEEATAGLSCPAALTDSEDESPEDMRLPSYGLCERGNTSSSPPGPRESSSLVVINQPAPIAPQLSGPGEASSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSTFYDVASGFAVSSLSEASTGVPAIPAWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE", "length": 691 }, "evidence": [ { "id": "A0AAA9SJH9", "url": "https://omabrowser.org/oma/group/A0AAA9SJH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CGU1-1", "protein_name": "Calcium-binding and coiled-coil domain-containing protein 1", "gene_name": "Calcoco1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHGELSEERDILSQQQGDHVARILELEDDIQTMSDKVLMKEVELDRVRDTVKALTREQEKLLRQLKEFQADKEQSEAELQTVREENCCLNTELEEAKSRQEEQGAQVQRLKDKLAHMKDTLGQAQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQEERTQSHVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWTEDAATEDEEATAGLSCPASLTDSEDESPEDMRLPSYGLCESGNTSSSPPGPREPSSLVVINQPAPIAPQFSGPGEASSSDSEAEDEKSVLMAAVQSGGEEASLLLPELGSAFYDVASAFTVSSLSEASPGVPANPPWKECPICKERFPAESDKDALEGHMDGHFFFSTQDPFTFE", "length": 691 }, "evidence": [ { "id": "A0AAA9SJH9", "url": "https://omabrowser.org/oma/group/A0AAA9SJH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P1Z2-1", "protein_name": "Calcium-binding and coiled-coil domain-containing protein 1", "gene_name": "CALCOCO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE", "length": 691 }, "evidence": [ { "id": "A0AAA9SJH9", "url": "https://omabrowser.org/oma/group/A0AAA9SJH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" }, { "name": "nuclear receptor-mediated steroid hormone signaling pathway", "id": "GO:0030518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030518", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH9" }, { "id": "PS51905", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51905" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBZ1-type", "eco_id": "ECO_0000259", "start_pos": 654, "end_pos": 680, "start_aa": "Trp", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 651 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIB5-1", "uniprot_ac": "A0AAA9SIB5", "uniprot_id": "A0AAA9SIB5_BOVIN", "mass": { "chemical_mass": 27477.0, "monoisotopic_mass": 27477.0 }, "refseq": {}, "gene_names": [ { "name": "MRM2", "type": "recommended", "evidence": [ { "id": "A0AAA9SIB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ] } ], "protein_names": [ { "name": "rRNA methyltransferase 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SIB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5/entry#names_and_taxonomy" } ] }, { "name": "16S rRNA (uridine(1369)-2'-O)-methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SIB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5/entry#names_and_taxonomy" } ] }, { "name": "16S rRNA [Um1369] 2'-O-methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SIB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5/entry#names_and_taxonomy" } ] }, { "name": "Protein ftsJ homolog 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SIB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5#function" }, { "database": "UniProtKB", "id": "ARBA00058412", "url": "https://www.uniprot.org/uniprotkb/ARBA00058412#function" }, { "database": "UniProtKB", "id": "F1MLL9", "url": "https://www.uniprot.org/uniprotkb/F1MLL9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5", "locus": { "chromosome": "25", "start_pos": 40983409, "end_pos": 40977160, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002477", "url": "https://www.ensembl.org/id/ENSBTAG00000002477" } ] } } ], "crossref": [ { "id": "A0AAA9SIB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002477", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002477", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "790010", "url": "https://www.ncbi.nlm.nih.gov/gene/790010", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:790010", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790010", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HRQTDHL", "url": "https://omabrowser.org/oma/group/HRQTDHL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLL9", "url": "https://www.orthodb.org/?gene=F1MLL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10920:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10920:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01728", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01728", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "47764", "url": "https://www.rhea-db.org/rhea/47764", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLL9", "url": "https://www.uniprot.org/uniprotkb/F1MLL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLL9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGGAWSLKLVWASLQRQRFHTTGSCYKSRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEMNERHQILRPGLRVLDCGAAPGAWSQVAVQRVNAAGTDPSAPVGFVLGVDLLHIFPLEGATFLCPADVTDPRTFRKIQELLPGGRADVILSDMAPNATGIRSLDHDRLISLCLSLLDMVPDVLHPRGTFLCKTWAGSQSQRLQKRLTQEFQNTRTVKPEASRKESSEVYLLATQYRGKPGGL", "length": 247, "header": "tr|A0AAA9SIB5-1|A0AAA9SIB5_BOVIN Isoform 1 of rRNA methyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=MRM2 PE=3 SV=1 CANONICAL=A0AAA9SIB5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5/entry#A0AAA9SIB5-1", "sequence": { "sequence": "MDGGAWSLKLVWASLQRQRFHTTGSCYKSRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEMNERHQILRPGLRVLDCGAAPGAWSQVAVQRVNAAGTDPSAPVGFVLGVDLLHIFPLEGATFLCPADVTDPRTFRKIQELLPGGRADVILSDMAPNATGIRSLDHDRLISLCLSLLDMVPDVLHPRGTFLCKTWAGSQSQRLQKRLTQEFQNTRTVKPEASRKESSEVYLLATQYRGKPGGL", "length": 247, "header": "tr|A0AAA9SIB5-1|A0AAA9SIB5_BOVIN Isoform 1 of rRNA methyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=MRM2 PE=3 SV=1 CANONICAL=A0AAA9SIB5-1" }, "locus": { "chromosome": "25", "start_pos": 40982390, "end_pos": 40978548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085980.1" } ] } }, { "isoform_ac": "F1MLL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5/entry#F1MLL9-1", "sequence": { "sequence": "MAGSLKLVWASLQRQRFHTTGSCYKSRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEMNERHQILRPGLRVLDCGAAPGAWSQVAVQRVNAAGTDPSAPVGFVLGVDLLHIFPLEGATFLCPADVTDPRTFRKIQELLPGGRADVILSDMAPNATGIRSLDHDRLISLCLSLLDMVPDVLHPRGTFLCKTWAGSQSQRLQKRLTQEFQNTRTVKPEASRKESSEVYLLATQYRGKPGGL", "length": 244, "header": "tr|F1MLL9-1|F1MLL9_BOVIN Computationally mapped isoform of rRNA methyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=MRM2 PE=3 SV=2 CANONICAL=A0AAA9SIB5-1" }, "locus": { "chromosome": "25", "start_pos": 40982390, "end_pos": 40977196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003214.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003214.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003214.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003214.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:790010", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790010", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZGI8-1", "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "Mrm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGYPKLVGVPLKVRRLHTAVCHYKGRTGAEHLWLMRHLKDPFVKAAKAESYRCRSAFKLLEMNEKHHILRPGLRVLDCGAAPGAWSQVAVQSVNATGADSSSPMGFVLGVDLLHMFPLAGATFLCPADVTDPRTFQRILELLPRRRADVILSDMAPNATGIRDLDHDRLISLCLTLVDMAVDILHPGGTLLCKTWAGSKSHLLQKRLAQEFRSTRVVKPEASRKESAEVYLLATQYHGRKGSTKQ", "length": 246 }, "evidence": [ { "id": "A0AAA9SIB5", "url": "https://omabrowser.org/oma/group/A0AAA9SIB5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GVF7-1", "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "Mrm2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAWYLKLVGVPLKVQRFHTTACGCKGRTGAEHLWLKRHLKDPFVKAAKVESYRCRSAFKLMAINEKHHILRPGLRVLDCGAAPGAWSQVAVQRVNATGTDCSSPVGYVLGVDLLHIFPLEGATFLCPADVTDPGTRQRILDLLPRRKADVILSDMAPNATGIRDLDHDRLISLCLTLVDMAVDILHPGGTLLCKTWAGRKSHLLQKRLTQEFQNTRVVKPEASRKESSEVYLLATQYRGGKGSEQ", "length": 245 }, "evidence": [ { "id": "A0AAA9SIB5", "url": "https://omabrowser.org/oma/group/A0AAA9SIB5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9CPY0-1", "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "Mrm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGHLKLVGVPLKVRRLHTAVCHYRGRTGAEHLWLTRHLKDPFVKAAKVESYRCRSAFKLLEMNEKHQILRPGLRVLDCGAAPGAWSQVAVQRVNATGADSSSPVGFVLGVDLLHIFPLAGATFLCPADVTDPRTFQKILELLPSRRADVILSDMAPNATGIRDLDHDKLISLCLTLVDMAVDILHPGGTLLCKTWAGSKSHLLQKRLTQEFQSTRVVKPEASRKESSEVYLLATQYRGGKGTRRP", "length": 246 }, "evidence": [ { "id": "A0AAA9SIB5", "url": "https://omabrowser.org/oma/group/A0AAA9SIB5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SXH3-1", "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "TRM7C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSGAGVPDFFYREAQRLGYVARSAFKLLQIQKQYKLIKPGSSVLDLGCAPGAWLQVACQSLGPLRSGGIVVGMDIKKVKVPPQCDSRVQTIAADVLNFPRQKIRELSPQQLGFSVILSDMCHSVSGITTRDAALSAELGMRALDLAVGQAAISQSPNDDDGGPNESRPGVLRHGGHLVIKLLESEDAQDFARICKPIFNKASWLRPKATRPSSREIYLICQGFR", "length": 224 }, "evidence": [ { "id": "A0AAA9SIB5", "url": "https://omabrowser.org/oma/group/A0AAA9SIB5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UI43-1", "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "MRM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGYLKLVCVSFQRQGFHTVGSRCKNRTGAEHLWLTRHLRDPFVKAAKVESYRCRSAFKLLEVNERHQILRPGLRVLDCGAAPGAWSQVAVQKVNAAGTDPSSPVGFVLGVDLLHIFPLEGATFLCPADVTDPRTSQRILEVLPGRRADVILSDMAPNATGFRDLDHDRLISLCLTLLSVTPDILQPGGTFLCKTWAGSQSRRLQRRLTEEFQNVRIIKPEASRKESSEVYFLATQYHGRKGTVKQ", "length": 246 }, "evidence": [ { "id": "A0AAA9SIB5", "url": "https://omabrowser.org/oma/group/A0AAA9SIB5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VDT6-1", "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "Mrm2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRLVFTGNCVFKRLLHTEIGGKYAKQQPRNLKGRSKSSQEWLTRQLADPYVEKARMMNYRCRSAFKLLEIDDKYGILRPGDTVLECGAAPGSWTQVAVERTNANGKQERAPQGAVFSIDLLHFHAVPGATIFGGMDFTSSLAQKRLREALQDRKVNCVLSDMAPNATGVRMLDQESITNLCYEVLRFALAMSAPQAHLVVKVWDNGDVPKLERDMLRFYEKVKRVKPRASRGDSAEHFLVARNFKGATDS", "length": 250 }, "evidence": [ { "id": "A0AAA9SIB5", "url": "https://omabrowser.org/oma/group/A0AAA9SIB5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit assembly", "id": "GO:1902775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902775", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "pmid": "" }, { "name": "RNA methylation", "id": "GO:0001510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001510", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "rRNA (uridine-2'-O-)-methyltransferase activity", "id": "GO:0008650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "47764", "name": "", "equation": "uridine(1369) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methyluridine(1369) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "47764", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47764" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIB5" }, { "id": "PF01728", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01728" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ribosomal RNA methyltransferase FtsJ", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 239, "start_aa": "Tyr", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIE1-1", "uniprot_ac": "A0AAA9SIE1", "uniprot_id": "A0AAA9SIE1_BOVIN", "mass": { "chemical_mass": 136331.0, "monoisotopic_mass": 136331.0 }, "refseq": { "ac": "XP_059735376", "name": "inverted formin-2 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735376" }, "gene_names": [ { "name": "INF2", "type": "recommended", "evidence": [ { "id": "A0AAA9SIE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" } ] }, { "name": "INF2", "type": "synonym", "evidence": [ { "id": "XP_059735376", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735376" } ] } ], "protein_names": [ { "name": "Inverted formin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SIE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1/entry#names_and_taxonomy" } ] }, { "name": "inverted formin-2 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_059735376", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735376" } ] } ], "function": [ { "annotation": "Severs actin filaments and accelerates their polymerization and depolymerization.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1#function" }, { "database": "UniProtKB", "id": "ARBA00058087", "url": "https://www.uniprot.org/uniprotkb/ARBA00058087#function" }, { "database": "UniProtKB", "id": "G5E5C0", "url": "https://www.uniprot.org/uniprotkb/G5E5C0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1", "locus": { "chromosome": "21", "start_pos": 69195143, "end_pos": 69166745, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007187", "url": "https://www.ensembl.org/id/ENSBTAG00000007187" } ] } } ], "crossref": [ { "id": "A0AAA9SIE1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007187", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007187", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22061", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22061", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538493", "url": "https://www.ncbi.nlm.nih.gov/gene/538493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46345:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46345:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06371", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06371", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059735376", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735376", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5C0", "url": "https://www.uniprot.org/uniprotkb/G5E5C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5C0-1", "url": "https://www.uniprot.org/uniprotkb/G5E5C0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSQGSAGGGPRQGPAWVGRGSRKVLRVWLSKMSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQVPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARIADALLQLTCVSCVRAVMNSQEGIQYILSNQAYVRQLSLALDTSNMMVKKQVFELLAALCIYSPEGHALTLDALDHYKTVCGQQYRFSVIMSELSDSDNVPYVATLLSVVNAIILGPEDVRARAQLRSEFIGLQLLDVLTRLRDLEDGDLLIQLEAFREARAEDEEELLRAFGGIDINSHQEVFSALFHKVSCSPASAHLLSVLQGLLHLEPSLRSSQLLWEALESLVNRAVLLATDGQECTLEEMVERLLSIKGRPHPRSLDKAHKSTQADFGQSQRGSSPQNSGTPTADLGGQQPAAALGSPPVASVQGERGPAPQPTAPEPLERPPPPPAPPLPGPTTAPRPPPPPPPPPPPPPPPPPPLPGMRAAFPSPPPPPPPPLPNSVRTIPPPPPLPGLGGPPPPPPPPLPGLGGPPPPPPLPGVSGPPTAGSVEEIIVAQVDGGLGSAWVPRHRRVNPPTLRMKKLNWQKLPSSVAREGSSMWATLSSPDTEVVEPDFSSIERLFSFPTAKPKEQAVAPARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMIRAGDSTKFDVEVLKQLLKLLPEKHEIENLRSFTEDQARLASADQFYLLLLNIPCYQLRIECMLLCEGTAVVLDMVRPKAQLLLAACESLLTSHRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEESHPDLLQLPQDLELPARAAGINLDAIHSESSTNLKKLLEMERKVSSSVPEVQEQYSHRLQASITDSQALEEVFQAIEQKQLELASYLCEDTQQLSLEDTLSTMKTFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEGGKAARRGGGKQEEVCVIDALLADIRKGFQLRKTARGRGDAEAASRAAATDPPRNKAPAATRDPVGGASPPTSEPGLDAAAAREPQGWDLADAVPTSRQPTGDSSETGGPGALERRSSWYTDASDFLPTEDPQGPQPPAGAWPVVLGDAQALKPLDFSDQPPKAMDLSPDAEEPPATLGARQAEASSADEGLEDAAAHCHRAGLPAAGPDEDGDGELTAPDSALDTSLDRSFSEDAVTDSSGSSTLPRAQGRTSKGTGKRRKKRSSRNQEEVAPDPDDNKTKRLCVIQ", "length": 1262, "header": "tr|A0AAA9SIE1-1|A0AAA9SIE1_BOVIN Isoform 1 of Inverted formin-2 OS=Bos taurus OX=9913 GN=INF2 PE=3 SV=1 CANONICAL=A0AAA9SIE1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1/entry#A0AAA9SIE1-1", "sequence": { "sequence": "MRSQGSAGGGPRQGPAWVGRGSRKVLRVWLSKMSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQVPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARIADALLQLTCVSCVRAVMNSQEGIQYILSNQAYVRQLSLALDTSNMMVKKQVFELLAALCIYSPEGHALTLDALDHYKTVCGQQYRFSVIMSELSDSDNVPYVATLLSVVNAIILGPEDVRARAQLRSEFIGLQLLDVLTRLRDLEDGDLLIQLEAFREARAEDEEELLRAFGGIDINSHQEVFSALFHKVSCSPASAHLLSVLQGLLHLEPSLRSSQLLWEALESLVNRAVLLATDGQECTLEEMVERLLSIKGRPHPRSLDKAHKSTQADFGQSQRGSSPQNSGTPTADLGGQQPAAALGSPPVASVQGERGPAPQPTAPEPLERPPPPPAPPLPGPTTAPRPPPPPPPPPPPPPPPPPPLPGMRAAFPSPPPPPPPPLPNSVRTIPPPPPLPGLGGPPPPPPPPLPGLGGPPPPPPLPGVSGPPTAGSVEEIIVAQVDGGLGSAWVPRHRRVNPPTLRMKKLNWQKLPSSVAREGSSMWATLSSPDTEVVEPDFSSIERLFSFPTAKPKEQAVAPARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMIRAGDSTKFDVEVLKQLLKLLPEKHEIENLRSFTEDQARLASADQFYLLLLNIPCYQLRIECMLLCEGTAVVLDMVRPKAQLLLAACESLLTSHRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEESHPDLLQLPQDLELPARAAGINLDAIHSESSTNLKKLLEMERKVSSSVPEVQEQYSHRLQASITDSQALEEVFQAIEQKQLELASYLCEDTQQLSLEDTLSTMKTFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEGGKAARRGGGKQEEVCVIDALLADIRKGFQLRKTARGRGDAEAASRAAATDPPRNKAPAATRDPVGGASPPTSEPGLDAAAAREPQGWDLADAVPTSRQPTGDSSETGGPGALERRSSWYTDASDFLPTEDPQGPQPPAGAWPVVLGDAQALKPLDFSDQPPKAMDLSPDAEEPPATLGARQAEASSADEGLEDAAAHCHRAGLPAAGPDEDGDGELTAPDSALDTSLDRSFSEDAVTDSSGSSTLPRAQGRTSKGTGKRRKKRSSRNQEEVAPDPDDNKTKRLCVIQ", "length": 1262, "header": "tr|A0AAA9SIE1-1|A0AAA9SIE1_BOVIN Isoform 1 of Inverted formin-2 OS=Bos taurus OX=9913 GN=INF2 PE=3 SV=1 CANONICAL=A0AAA9SIE1-1" }, "locus": { "chromosome": "21", "start_pos": 69191605, "end_pos": 69176118, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134621.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134621.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086010.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086010.1" } ] } }, { "isoform_ac": "G5E5C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1/entry#G5E5C0-1", "sequence": { "sequence": "MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQVPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARIADALLQLTCVSCVRAVMNSQEGIQYILSNQAYVRQLSLALDTSNMMVKKQVFELLAALCIYSPEGHALTLDALDHYKTVCGQQYRFSVIMSELSDSDNVPYVATLLSVVNAIILGPEDVRARAQLRSEFIGLQLLDVLTRLRDLEDGDLLIQLEAFREARAEDEEELLRAFGGIDINSHQEVFSALFHKVSCSPASAHLLSVLQGLLHLEPSLRSSQLLWEALESLVNRAVLLATDGQECTLEEMVERLLSIKGRPHPRSLDKAHKSTQADFGQSQRGSSPQNSGTPTADLGGQQPAAALGSPPVASVQGERGPAPQPTAPEPLERPPPPPAPPLPGPTTAPRPPPPPPPPPPPPPPPPPPLPGMRAAFPSPPPPPPPPLPNSVRTIPPPPPLPGLGGPPPPPPPPLPGLGGPPPPPPLPGVSGPPTAGSVEEIIVAQVDGGLGSAWVPRHRRVNPPTLRMKKLNWQKLPSSVAREGSSMWATLSSPDTEVVEPDFSSIERLFSFPTAKPKEQAVAPARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMIRAGDSTKFDVEVLKQLLKLLPEKHEIENLRSFTEDQARLASADQFYLLLLNIPCYQLRIECMLLCEGTAVVLDMVRPKAQLLLAACESLLTSHRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEESHPDLLQLPQDLELPARAAGINLDAIHSESSTNLKKLLEMERKVSSSVPEVQEQYSHRLQASITDSQALEEVFQAIEQKQLELASYLCEDTQQLSLEDTLSTMKTFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEGGKAARRGGGKQEEVCVIDALLADIRKGFQLRKTARGRGDAEAASRAAATDPPRNKAPAATRDPVGGASPPTSEPGLDAAAAREPQGWDLADAVPTSRQPTGDSSETGGPGALERRSSWYTDASDFLPTEDPQGPQPPAGAWPVVLGDAQALKPLDFSDQPPKAMDLSPDAEEPPATLGARQAEASSADEGLEDAAAHCHRAGLPAAGPDEDGDGELTAPDSALDTSLDRSFSEDAVTDSSGSSTLPRAQGRTSKGTGKRRKKRSSRNQEGLRPRSRAK", "length": 1221, "header": "tr|G5E5C0-1|G5E5C0_BOVIN Computationally mapped isoform of Inverted formin-2 OS=Bos taurus OX=9913 GN=INF2 PE=3 SV=3 CANONICAL=A0AAA9SIE1-1" }, "locus": { "chromosome": "21", "start_pos": 69194139, "end_pos": 69178956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012349.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012349.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012349.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012349.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 443, "start_aa": "Thr", "end_pos": 443, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr443", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 463, "start_aa": "Thr", "end_pos": 463, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr463", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1253, "end_pos": 1255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" }, { "id": "PS51444", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51444" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FH2", "eco_id": "ECO_0000259", "start_pos": 575, "end_pos": 965, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SIE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" }, { "id": "PS51232", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51232" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GBD/FH3", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 362, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SIE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE1" }, { "id": "PS51082", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WH2", "eco_id": "ECO_0000259", "start_pos": 993, "end_pos": 1008, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 443, 463 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1253, "end_pos": 1255 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIE6-1", "uniprot_ac": "A0AAA9SIE6", "uniprot_id": "A0AAA9SIE6_BOVIN", "mass": { "chemical_mass": 51570.0, "monoisotopic_mass": 51570.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112442391", "type": "recommended", "evidence": [ { "id": "A0AAA9SIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain containing 5B", "type": "recommended", "evidence": [ { "id": "A0AAA9SIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112442391", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SIE6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIE6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768229", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768229", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENQTSGRGRFADIPGAGSPASAPFQGTRRENPDSDLEKLRVCFRTFSSSDESDPIKALRRLHELCSLWLRPDLHTKEEMVDRLVLEQFVMCMPPDIQVLVKSSGAETCKDLEEVLRKKQKLQKWAGVRVQGEDFLMPVSGVEMLGSEVSEGHGEGDRAREPQSTVSVVPPDEGQPERQDGQHLPGAKDLSTGQGQKALPPETIPETGELECQTPSKENLEKDLLEDTGVTRTLLSQERELLQNHEGDVSTPSGSRRGPLKNHRHVKRKQDSTPTCQDVGQESATCLDQREFSGQLGSHSVGAFGSMGPTSHSEGAGTPGRARSECKVCKKSFPYQYQLTVHQRTHTGERPFQCDICAKGFIQPSDLRVHQRIHTGEKPYSCDICLKKFTHNSTMHAHKVTHSQEKPFRCEHCDRAFAYRANLTVHRRTHSGLKPYVCPECHRAFSQLGSFKRHRKIHSR", "length": 461, "header": "tr|A0AAA9SIE6-1|A0AAA9SIE6_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC112442391 PE=3 SV=2 CANONICAL=A0AAA9SIE6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6/entry#A0AAA9SIE6-1", "sequence": { "sequence": "MAENQTSGRGRFADIPGAGSPASAPFQGTRRENPDSDLEKLRVCFRTFSSSDESDPIKALRRLHELCSLWLRPDLHTKEEMVDRLVLEQFVMCMPPDIQVLVKSSGAETCKDLEEVLRKKQKLQKWAGVRVQGEDFLMPVSGVEMLGSEVSEGHGEGDRAREPQSTVSVVPPDEGQPERQDGQHLPGAKDLSTGQGQKALPPETIPETGELECQTPSKENLEKDLLEDTGVTRTLLSQERELLQNHEGDVSTPSGSRRGPLKNHRHVKRKQDSTPTCQDVGQESATCLDQREFSGQLGSHSVGAFGSMGPTSHSEGAGTPGRARSECKVCKKSFPYQYQLTVHQRTHTGERPFQCDICAKGFIQPSDLRVHQRIHTGEKPYSCDICLKKFTHNSTMHAHKVTHSQEKPFRCEHCDRAFAYRANLTVHRRTHSGLKPYVCPECHRAFSQLGSFKRHRKIHSR", "length": 461, "header": "tr|A0AAA9SIE6-1|A0AAA9SIE6_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC112442391 PE=3 SV=2 CANONICAL=A0AAA9SIE6-1" }, "locus": { "chromosome": "18", "start_pos": 63652992, "end_pos": 63650014, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118221.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118221.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083515.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083515.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768229", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768229", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 325, "end_pos": 352, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIE6" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 122, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 393, "end_pos": 395 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIF1-1", "uniprot_ac": "A0AAA9SIF1", "uniprot_id": "A0AAA9SIF1_BOVIN", "mass": { "chemical_mass": 13336.0, "monoisotopic_mass": 13336.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SIF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SIF1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIF1", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SIF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRTAFILGSSLPLLMVHWNCVIGYLQRFWGASCYFWQAQWERLLSTFEGKEWLLYILGVTQVPLLVYRTLSGLLLVLDVTGKPNFISRYRIHVDNNGRSGQTWLCHGMKLNRD", "length": 114, "header": "tr|A0AAA9SIF1-1|A0AAA9SIF1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIF1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1/entry#A0AAA9SIF1-1", "sequence": { "sequence": "MRRTAFILGSSLPLLMVHWNCVIGYLQRFWGASCYFWQAQWERLLSTFEGKEWLLYILGVTQVPLLVYRTLSGLLLVLDVTGKPNFISRYRIHVDNNGRSGQTWLCHGMKLNRD", "length": 114, "header": "tr|A0AAA9SIF1-1|A0AAA9SIF1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIF1-1" }, "locus": { "chromosome": "7", "start_pos": 66029286, "end_pos": 66019581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088007.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088007.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083520.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083520.1" } ] } }, { "isoform_ac": "A0AAA9T0Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF1/entry#A0AAA9T0Y9-1", "sequence": { "sequence": "MKEEAGHMLHNENPNQEGHIWGSMRRTAFILGSSLPLLMVHWNCVIGYLQRFWGASCYFWQAQWERLLSTFEGKEWLLYILVWPDLALPWHETERLNSPQ", "length": 100, "header": "tr|A0AAA9T0Y9-1|A0AAA9T0Y9_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIF1-1" }, "locus": { "chromosome": "7", "start_pos": 66031750, "end_pos": 66019563, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112460.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112460.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091363.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIF7-1", "uniprot_ac": "A0AAA9SIF7", "uniprot_id": "A0AAA9SIF7_BOVIN", "mass": { "chemical_mass": 59619.0, "monoisotopic_mass": 59619.0 }, "refseq": { "ac": "XP_024852959", "name": "raftlin isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852959" }, "gene_names": [ { "name": "RFTN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SIF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ] }, { "name": "RFTN1", "type": "synonym", "evidence": [ { "id": "XP_024852959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852959" } ] } ], "protein_names": [ { "name": "Raftlin, lipid raft linker 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SIF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#names_and_taxonomy" } ] }, { "name": "raftlin isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024852959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852959" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RFTN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7", "locus": { "chromosome": "1", "start_pos": 153335290, "end_pos": 153561415, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030593", "url": "https://www.ensembl.org/id/ENSBTAG00000030593" } ] } } ], "crossref": [ { "id": "A0AAA9SIF7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030593", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030593", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506782", "url": "https://www.ncbi.nlm.nih.gov/gene/506782", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N1Q3", "url": "https://www.orthodb.org/?gene=F1N1Q3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17601", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17601", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17601:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17601:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024852959", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1D5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Q3", "url": "https://www.uniprot.org/uniprotkb/F1N1Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1Q3-1", "url": "https://www.uniprot.org/uniprotkb/F1N1Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCGLNKLEKRDDRRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 549, "header": "tr|A0AAA9SIF7-1|A0AAA9SIF7_BOVIN Isoform 1 of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=1 CANONICAL=A0AAA9SIF7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#A0AAA9SIF7-1", "sequence": { "sequence": "MGCGLNKLEKRDDRRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 549, "header": "tr|A0AAA9SIF7-1|A0AAA9SIF7_BOVIN Isoform 1 of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=1 CANONICAL=A0AAA9SIF7-1" }, "locus": { "chromosome": "1", "start_pos": 153543136, "end_pos": 153336294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101252.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101252.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086030.1" } ] } }, { "isoform_ac": "A0AAA9T0H3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#A0AAA9T0H3-1", "sequence": { "sequence": "MLQTVRRHRTQGRRGGRERVCFEHAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 525, "header": "tr|A0AAA9T0H3-1|A0AAA9T0H3_BOVIN Computationally mapped isoform of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=1 CANONICAL=A0AAA9SIF7-1" }, "locus": { "chromosome": "1", "start_pos": 153494810, "end_pos": 153336294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128443.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128443.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089145.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089145.1" } ] } }, { "isoform_ac": "A0AAA9T9U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#A0AAA9T9U8-1", "sequence": { "sequence": "MAPGAGSVGRGGLGPTFLKRKERNQPWRARGRGTPRAVCGGQWAPPARGRRGRKRRGGFEATAAEMGCGLNKLEKRDDRRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 614, "header": "tr|A0AAA9T9U8-1|A0AAA9T9U8_BOVIN Computationally mapped isoform of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=1 CANONICAL=A0AAA9SIF7-1" }, "locus": { "chromosome": "1", "start_pos": 153560925, "end_pos": 153336294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134763.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134763.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093646.1" } ] } }, { "isoform_ac": "A0AAA9TAD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#A0AAA9TAD4-1", "sequence": { "sequence": "MPSSLSSAEMGCGLNKLEKRDDRRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 558, "header": "tr|A0AAA9TAD4-1|A0AAA9TAD4_BOVIN Computationally mapped isoform of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=1 CANONICAL=A0AAA9SIF7-1" }, "locus": { "chromosome": "1", "start_pos": 153543918, "end_pos": 153336294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124998.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124998.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093835.1" } ] } }, { "isoform_ac": "A0AAA9U1D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#A0AAA9U1D5-1", "sequence": { "sequence": "MGVGCHFLLQGVFSAQGSNPGLPHCRRFLYHLSHQGSRHGRWGEAKLPIQAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 551, "header": "tr|A0AAA9U1D5-1|A0AAA9U1D5_BOVIN Computationally mapped isoform of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=1 CANONICAL=A0AAA9SIF7-1" }, "locus": { "chromosome": "1", "start_pos": 153515588, "end_pos": 153336294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100740.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100740.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103592.1" } ] } }, { "isoform_ac": "F1N1Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7/entry#F1N1Q3-1", "sequence": { "sequence": "MDDASAQSLTASSAEMGCGLNKLEKRDDRRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPRASAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTPEREKTPLEHIFRAILIKKNDRSQNADLHNEGYILELDCCSSLDHLTDQKVLPEFIKKIQEAASRGLKFVGVVPQYRCPGSPAGSCPPADAQDETQEPGGHGAAEELGAADAAVGTDGSLEPGQGPREETPATQQPNSPPGEGDGAESPARGTPEGPDADLPSEGPGEPLAGKMEIFALFNKPKSHQKCRQYYPVTIPLRVSKNGPTVCGLDANWLEHMSDHFRKGGVLVNAVSSLSLVHDSLHDLTDGVFIFEAVSTEDSRTTQGYDAIVVEQWTVLDGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVIRTTREGTVSTKQVVFLQRPCLPQKVKKKESKFQWRFSRDEMRNRPTRKSKGKFCVRGKRQAEESEKNPEDQLPRVGDAGGHVPGREDWAEGPAEKPRPDGQPCVEGEAVQNGPSGRSPAPAEGSVGLTGPEPGEDAGVEVAPGPAAAEHP", "length": 564, "header": "tr|F1N1Q3-1|A0AAA9SIF7_BOVIN Computationally mapped isoform of Raftlin, lipid raft linker 1 OS=Bos taurus OX=9913 GN=RFTN1 PE=3 SV=4 CANONICAL=A0AAA9SIF7-1" }, "locus": { "chromosome": "1", "start_pos": 153545402, "end_pos": 153336294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043219.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043219.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040806.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040806.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 396, "start_aa": "Thr", "end_pos": 396, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr396", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 89, "start_aa": "Thr", "end_pos": 89, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "T cell antigen processing and presentation", "id": "GO:0002457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "positive regulation of interleukin-17 production", "id": "GO:0032740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032740", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "membrane raft assembly", "id": "GO:0001765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "positive regulation of growth rate", "id": "GO:0040010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" }, { "name": "protein transport into membrane raft", "id": "GO:0032596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032596", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 89, 396 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIG0-1", "uniprot_ac": "A0AAA9SIG0", "uniprot_id": "A0AAA9SIG0_BOVIN", "mass": { "chemical_mass": 39333.0, "monoisotopic_mass": 39333.0 }, "refseq": { "ac": "XP_002691086", "name": "cell cycle control protein 50B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691086" }, "gene_names": [ { "name": "TMEM30B", "type": "recommended", "evidence": [ { "id": "A0AAA9SIG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0" } ] }, { "name": "TMEM30B", "type": "synonym", "evidence": [ { "id": "XP_002691086", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691086" } ] } ], "protein_names": [ { "name": "Cell cycle control protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SIG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0/entry#names_and_taxonomy" } ] }, { "name": "cell cycle control protein 50B", "type": "synonym", "evidence": [ { "id": "XP_002691086", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691086" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM30B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0", "locus": { "chromosome": "10", "start_pos": 73388154, "end_pos": 73396576, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065174", "url": "https://www.ensembl.org/id/ENSBTAG00000065174" } ] } } ], "crossref": [ { "id": "A0AAA9SIG0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "539324", "url": "https://www.ncbi.nlm.nih.gov/gene/539324", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539324", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539324", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WWTDTNV", "url": "https://omabrowser.org/oma/group/WWTDTNV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10926", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10926", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10926:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10926:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03381", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03381", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691086", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691086", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTWSATARGAHQPDNTAFTQQRLPAWHPLLSASITLPLFFCAGLAFIGLGLGLYYSSNGIKELAYDYTGDSGTGNCSVCAMAGQGRAPPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDDSQLSGLPSSLRHPVNECAPYQYSAAGLPIAPCGAIANSLFNDSFSLWHQRQPNGPYVEVPLDRTGIAWWTDYHVKFRNPPLVNGSLALAFQGTAPPPNWHRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGAYRVNITYNYPVRAFNGHKSLIFSSISWMGGKNPFLGIAYLLVGSLCILVGFVMLVVYIRYQDQNDDEEDDE", "length": 353, "header": "tr|A0AAA9SIG0-1|A0AAA9SIG0_BOVIN Isoform 1 of Cell cycle control protein OS=Bos taurus OX=9913 GN=TMEM30B PE=3 SV=1 CANONICAL=A0AAA9SIG0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0/entry#A0AAA9SIG0-1", "sequence": { "sequence": "MTWSATARGAHQPDNTAFTQQRLPAWHPLLSASITLPLFFCAGLAFIGLGLGLYYSSNGIKELAYDYTGDSGTGNCSVCAMAGQGRAPPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDDSQLSGLPSSLRHPVNECAPYQYSAAGLPIAPCGAIANSLFNDSFSLWHQRQPNGPYVEVPLDRTGIAWWTDYHVKFRNPPLVNGSLALAFQGTAPPPNWHRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGAYRVNITYNYPVRAFNGHKSLIFSSISWMGGKNPFLGIAYLLVGSLCILVGFVMLVVYIRYQDQNDDEEDDE", "length": 353, "header": "tr|A0AAA9SIG0-1|A0AAA9SIG0_BOVIN Isoform 1 of Cell cycle control protein OS=Bos taurus OX=9913 GN=TMEM30B PE=3 SV=1 CANONICAL=A0AAA9SIG0-1" }, "locus": { "chromosome": "10", "start_pos": 73388154, "end_pos": 73385067, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129939.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129939.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083707.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539324", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539324", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FED1-1", "protein_name": "Cell cycle control protein", "gene_name": "TMEM30B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTWSATARGAHQPDNTAFTQQRLPAWQPLLSASIALPLFFCAGLAFIGLGLGLYYSSNGIKELEYDYTGDSGLSNCSVCAAAGQGRAPPPRCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDDAQLSGLPSALRHPVNECAPYQLSAAGLPIAPCGAIANSLFNDSFSLWYQRQPGGPYVEVPLDRTGIAWWTDYHVKFRNPPLVNGSLALAFRGTAPPPNWHRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGAYRVNITYNYPVRAFGGHKLIIFSSISWMGGKNPFLGIAYLVVGSLCILTGFVMLVVYIRYQDQNDEDEEDE", "length": 353 }, "evidence": [ { "id": "A0AAA9SIG0", "url": "https://omabrowser.org/oma/group/A0AAA9SIG0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3Z9E9-1", "protein_name": "Cell cycle control protein", "gene_name": "Tmem30b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTWSASARGAQQPDNTAFTQQRLPAWQPLLSAGITLPLFFCAGLAFIGLGLGLFYSSNGIQELEYDYTGNPGTGNCSVCAAKGQDRAPPPSCQCSWSFTLPELFPGPVYLYYELSNFYQNNRRYGVSRDDAQLSGLASALRHPANECAPYQFSSDGLPIAPCGAIANSLFNDSFSLWHQRQPADPFVEVPLDRTAIAWWTDYHVKFRNPPLVNGSLALAFKGTAPPPNWHRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGTYRVNITYNYPVRAFGGHKLIILSNISWMGGKNPFLGIAYLVVGSLCILMGFVMLVVYIRYQDQDDDDNDDE", "length": 353 }, "evidence": [ { "id": "A0AAA9SIG0", "url": "https://omabrowser.org/oma/group/A0AAA9SIG0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P42838-1", "protein_name": "Phospholipid-transporting ATPase accessory subunit LEM3", "gene_name": "LEM3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDTLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK", "length": 414 }, "evidence": [ { "id": "A0AAA9SIG0", "url": "https://omabrowser.org/oma/group/A0AAA9SIG0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q3MIR4-1", "protein_name": "Cell cycle control protein 50B", "gene_name": "TMEM30B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTWSATARGAHQPDNTAFTQQRLPAWQPLLSASIALPLFFCAGLAFIGLGLGLYYSSNGIKELEYDYTGDPGTGNCSVCAAAGQGRALPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDDAQLSGLPSALRHPVNECAPYQRSAAGLPIAPCGAIANSLFNDSFSLWHQRQPGGPYVEVPLDRSGIAWWTDYHVKFRNPPLVNGSLALAFQGTAPPPNWRRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGAYRVNITYNYPVRAFGGHKLLIFSSISWMGGKNPFLGIAYLVVGSLCILTGFVMLVVYIRYQDQDDDDEE", "length": 351 }, "evidence": [ { "id": "A0AAA9SIG0", "url": "https://omabrowser.org/oma/group/A0AAA9SIG0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BHG3-1", "protein_name": "Cell cycle control protein 50B", "gene_name": "Tmem30b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTWSATARGAHQPDNTAFTQQRLPAWQPLLSAGIALPLFFCAGLAFIGLGLGLFYSSNGIKELEYDYTGNPGTGDCSVCAAKGQGRAPPPGCACSWSFTLPELFPGPVYLYYELSNFYQNNRRYGVSRDDAQLSGLASALRHPANECAPYQFRSDGLPIAPCGAIANSLFNDSFSLWHQRQPSDPFVEVPLDRTAIAWWTDYHVKFRNPPLVNGSLALAFRGTAPPPNWHRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGTYRVNITYNYPVRAFGGHKLIILSNISWMGGKNPFLGIAYLVVGSLCIVMGFVMLVVYIRYQDQDDDDNDDE", "length": 353 }, "evidence": [ { "id": "A0AAA9SIG0", "url": "https://omabrowser.org/oma/group/A0AAA9SIG0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of protein exit from endoplasmic reticulum", "id": "GO:0070863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070863", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aminophospholipid flippase activity", "id": "GO:0015247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015247", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 213, "end_pos": 215 }, { "start_pos": 241, "end_pos": 243 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK90-1", "uniprot_ac": "A0AAA9SK90", "uniprot_id": "A0AAA9SK90_BOVIN", "mass": { "chemical_mass": 100855.0, "monoisotopic_mass": 100855.0 }, "refseq": {}, "gene_names": [ { "name": "PIWIL4", "type": "recommended", "evidence": [ { "id": "A0AAA9SK90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ] } ], "protein_names": [ { "name": "Piwi like RNA-mediated silencing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SK90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIWIL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90", "locus": { "chromosome": "15", "start_pos": 15849522, "end_pos": 15905289, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014910", "url": "https://www.ensembl.org/id/ENSBTAG00000014910" } ] } } ], "crossref": [ { "id": "A0AAA9SK90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK90", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014910", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014910", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02845", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02845", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04658", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04658", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MZ84", "url": "https://www.orthodb.org/?gene=F1MZ84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22891", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22891", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23278", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23278", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T175", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T175", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T175-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T175-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ84", "url": "https://www.uniprot.org/uniprotkb/F1MZ84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ84-1", "url": "https://www.uniprot.org/uniprotkb/F1MZ84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAKKRPHGDLAASGLRGDKSGRARVRARGMARSLGAAEPPSVALIDNEASSSSDCERTSRISQKCGISPSDSGCTFKERGGKVRRDIMDLAVCTREKLAHVRDCKTGSSGIPVKLVTNLFNLDVPQDWQLYQYHVTYSPDIESRRLRIALLYSHRELSNKAKAFDGVILFLSQKLEEKGGQRATCMRPQSCPTFCDHMDRSLPDSSVHGVLQVTELSSETQRGETVKMTITLTRELPASSPVCIQVFNIIFKKILKKLSMYQIGRNFYKPSEPVEIPQHKLSLWPGFAISVSHFESKLLLSANVSYKILRNETVLEFMTDLCRKTSESCFTQTCEKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHTFRKRDGAEITYVDYYKQQYDITLSDLNQPVLVSLLKNKKNDNSEAQMAHLIPELCFLTGMPGQATSDFQLMKAVAKETRLDPLVRQQHLARLADDFQRNKDARFELETWGLHFGCQMSLTGRIAPAEKIIMQDHICQPASAADWSKDIRTCKVLSAQSLNKWLVICSNRAESVTENFLNCLRRVGGPMGFNVDRPKIIKVQENPAAFIHAIQKHVKYEVQLVMCILPSIQTSYYDSIKKYLSSDCPVPSQCVLAQTLNKQGMMLSVATKIAMQMICKLGGELWAVEIPLKSLMVVGINVCKDAFSQGTMVVGFVASINPRITRWFSRCILQRTTAHVADCLKVFMIGALNRWYRHNQGLPARIIVYRDGVGDGQLQTLVDYEVPQLLSSVIEASSNTSPKLSVIVVRKKGMPRFLVETGRNLQNPPLGTVVDSEATRPEWYDFYLISQMACRGTVNPTYYNVIYDDNGLKPDHMQRLTFKLCHVYYNWMGLISIPAPCQYARKLTFLVAQSLHKEPSLELANSLFYL", "length": 894, "header": "tr|A0AAA9SK90-1|A0AAA9SK90_BOVIN Isoform 1 of Piwi like RNA-mediated silencing 4 OS=Bos taurus OX=9913 GN=PIWIL4 PE=3 SV=1 CANONICAL=A0AAA9SK90-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90/entry#A0AAA9SIK6-1", "sequence": { "sequence": "MPAKKRPHGDLAASGLRGDKSGRARVRARGMARSLGAAEPPSVALIDNEASSSSDCERTSRISQKCGISPSDSGCTFKERGGKVRRDIMDLAVCTREKLAHVRDCKTGSSGIPVKLVTNLFNLDVPQDWQLYQYHVTYSPDIESRRLRIALLYSHRELSNKAKAFDGVILFLSQKLEEKVTELSSETQRGETVKMTITLTRELPASSPVCIQVFNIIFKKILKKLSMYQIGRNFYKPSEPVEIPQHKYNNKTYRIDDIDWSVKPTHTFRKRDGAEITYVDYYKQQYDITLSDLNQPVLVSLLKNKKNDNSEAQMAHLIPELCFLTGMPGQATSDFQLMKAVAKETRLDPLVRQQHLARLADDFQRNKDARFELETWGLHFGCQMSLTGRIAPAEKIIMQDHICQPASAADWSKDIRTCKVLSAQSLNKWLVICSNRAESVTENFLNCLRRVGGPMGFNVDRPKIIKVQENPAAFIHAIQKHVKYEVQLVMCILPSIQTSYYDSIKKYLSSDCPVPSQCVLAQTLNKQGMMLSVATKIAMQMICKLGGELWAVEIPLKSLMVVGINVCKDAFSQGTMVVGFVASINPRITRWFSRCILQRTTAHVADCLKVFMIGALNRWYRHNQGLPARIIVYRDGVGDGQLQTLVDYEVPQLLSSVIEASSNTSPKLSVIVVRKKGMPRFLVETGRNLQNPPLGTVVDSEATRPEWYDFYLISQMACRGTVNPTYYNVIYDDNGLKPDHMQRLTFKLCHVYYNWMGLISIPAPCQYARKLTFLVAQSLHKEPSLELANSLFYL", "length": 794, "header": "tr|A0AAA9SIK6-1|A0AAA9SK90_BOVIN Computationally mapped isoform of Piwi like RNA-mediated silencing 4 OS=Bos taurus OX=9913 GN=PIWIL4 PE=3 SV=1 CANONICAL=A0AAA9SK90-1" }, "locus": { "chromosome": "15", "start_pos": 15905090, "end_pos": 15850062, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083755.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083755.1" } ] } }, { "isoform_ac": "A0AAA9SK90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90/entry#A0AAA9SK90-1", "sequence": { "sequence": "MPAKKRPHGDLAASGLRGDKSGRARVRARGMARSLGAAEPPSVALIDNEASSSSDCERTSRISQKCGISPSDSGCTFKERGGKVRRDIMDLAVCTREKLAHVRDCKTGSSGIPVKLVTNLFNLDVPQDWQLYQYHVTYSPDIESRRLRIALLYSHRELSNKAKAFDGVILFLSQKLEEKGGQRATCMRPQSCPTFCDHMDRSLPDSSVHGVLQVTELSSETQRGETVKMTITLTRELPASSPVCIQVFNIIFKKILKKLSMYQIGRNFYKPSEPVEIPQHKLSLWPGFAISVSHFESKLLLSANVSYKILRNETVLEFMTDLCRKTSESCFTQTCEKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHTFRKRDGAEITYVDYYKQQYDITLSDLNQPVLVSLLKNKKNDNSEAQMAHLIPELCFLTGMPGQATSDFQLMKAVAKETRLDPLVRQQHLARLADDFQRNKDARFELETWGLHFGCQMSLTGRIAPAEKIIMQDHICQPASAADWSKDIRTCKVLSAQSLNKWLVICSNRAESVTENFLNCLRRVGGPMGFNVDRPKIIKVQENPAAFIHAIQKHVKYEVQLVMCILPSIQTSYYDSIKKYLSSDCPVPSQCVLAQTLNKQGMMLSVATKIAMQMICKLGGELWAVEIPLKSLMVVGINVCKDAFSQGTMVVGFVASINPRITRWFSRCILQRTTAHVADCLKVFMIGALNRWYRHNQGLPARIIVYRDGVGDGQLQTLVDYEVPQLLSSVIEASSNTSPKLSVIVVRKKGMPRFLVETGRNLQNPPLGTVVDSEATRPEWYDFYLISQMACRGTVNPTYYNVIYDDNGLKPDHMQRLTFKLCHVYYNWMGLISIPAPCQYARKLTFLVAQSLHKEPSLELANSLFYL", "length": 894, "header": "tr|A0AAA9SK90-1|A0AAA9SK90_BOVIN Isoform 1 of Piwi like RNA-mediated silencing 4 OS=Bos taurus OX=9913 GN=PIWIL4 PE=3 SV=1 CANONICAL=A0AAA9SK90-1" }, "locus": { "chromosome": "15", "start_pos": 15905090, "end_pos": 15850062, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101600.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101600.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085726.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085726.1" } ] } }, { "isoform_ac": "A0AAA9T175-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90/entry#A0AAA9T175-1", "sequence": { "sequence": "MPAKKRPHGDLAASGLRGDKSGRARVRARGMARSLGAAEPPSVALIDNEASSSSDCERTSRISQKCGISPSDSGCTFKERGGKVRRDIMDLAVCTREKLAHVRDCKTGSSGIPVKLVTNLFNLDVPQDWQLYQYHVTYSPDIESRRLRIALLYSHRELSNKAKAFDGVILFLSQKLEEKVTELSSETQRGETVKMTITLTRELPASSPVCIQVFNIIFKKILKKLSMYQIGRNFYKPSEPVEIPQHKLSLWPGFAISVSHFESKLLLSANVSYKILRNETVLEFMTDLCRKTSESCFTQTCEKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHTFRKRDGAEITYVDYYKQQYDITLSDLNQPVLVSLLKNKKNDNSEAQMAHLIPELCFLTGMPGQATSDFQLMKAVAKETRLDPLVRQQHLARLADDFQRNKDARFELETWGLHFGCQMSLTGRIAPAEKIIMQDHICQPASAADWSKDIRTCKVLSAQSLNKWLVICSNRAESVTENFLNCLRRVGGPMGFNVDRPKIIKVQENPAAFIHAIQKHVKYEVQLVMCILPSIQTSYYDSIKKYLSSDCPVPSQCVLAQTLNKQGMMLSVATKIAMQMICKLGGELWAVEIPLKSLMVVGINVCKDAFSQGTMVVGFVASINPRITRWFSRCILQRTTAHVADCLKVFMIGALNRWYRHNQGLPARIIVYRDGVGDGQLQTLVDYEVPQLLSSVIEASSNTSPKLSVIVVRKKGMPRFLVETGRNLQNPPLGTVVDSEATRPEWYDFYLISQMACRGTVNPTYYNVIYDDNGLKPDHMQRLTFKLCHVYYNWMGLISIPAPCQYARKLTFLVAQSLHKEPSLELANSLFYL", "length": 860, "header": "tr|A0AAA9T175-1|A0AAA9T175_BOVIN Computationally mapped isoform of Piwi like RNA-mediated silencing 4 OS=Bos taurus OX=9913 GN=PIWIL4 PE=3 SV=1 CANONICAL=A0AAA9SK90-1" }, "locus": { "chromosome": "15", "start_pos": 15905090, "end_pos": 15850062, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093097.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093097.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089410.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089410.1" } ] } }, { "isoform_ac": "F1MZ84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90/entry#F1MZ84-1", "sequence": { "sequence": "MDLAVCTREKLAHVRDCKTGSSGIPVKLVTNLFNLDVPQDWQLYQYHVTYSPDIESRRLRIALLYSHRELSNKAKAFDGVILFLSQKLEEKVTELSSETQRGETVKMTITLTRELPASSPVCIQVFNIIFKKILKKLSMYQIGRNFYKPSEPVEIPQHKLSLWPGFAISVSHFESKLLLSANVSYKILRNETVLEFMTDLCRKTSESCFTQTCEKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHTFRKRDGAEITYVDYYKQQYDITLSDLNQPVLVSLLKNKKNDNSEAQMAHLIPELCFLTGMPGQATSDFQLMKAVAKETRLDPLVRQQHLARLADDFQRNKDARFELETWGLHFGCQMSLTGRIAPAEKIIMQDHICQPASAADWSKDIRTCKVLSAQSLNKWLVICSNRAESVTENFLNCLRRVGGPMGFNVDRPKIIKVQENPAAFIHAIQKHVKYEVQLVMCILPSIQTSYYDSIKKYLSSDCPVPSQCVLAQTLNKQGMMLSVATKIAMQMICKLGGELWAVEIPLKSLMVVGINVCKDAFSQGTMVVGFVASINPRITRWFSRCILQRTTAHVADCLKVFMIGALNRWYRHNQGLPARIIVYRDGVGDGQLQTLVDYEVPQLLSSVIEASSNTSPKLSVIVVRKKGMPRFLVETGRNLQNPPLGTVVDSEATRPEWYDFYLISQMACRGTVNPTYYNVIYDDNGLKPDHMQRLTFKLCHVYYNWMGLISIPAPCQYARKLTFLVAQSLHKEPSLELANSLFYL", "length": 772, "header": "tr|F1MZ84-1|F1MZ84_BOVIN Computationally mapped isoform of Piwi like RNA-mediated silencing 4 OS=Bos taurus OX=9913 GN=PIWIL4 PE=3 SV=4 CANONICAL=A0AAA9SK90-1" }, "locus": { "chromosome": "15", "start_pos": 15901055, "end_pos": 15850062, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019851.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019851.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019851.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019851.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "piRNA binding", "id": "GO:0034584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034584", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "epithelial structure maintenance", "id": "GO:0010669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" }, { "id": "PS50821", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50821" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PAZ", "eco_id": "ECO_0000259", "start_pos": 314, "end_pos": 426, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SK90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK90" }, { "id": "PS50822", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50822" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Piwi", "eco_id": "ECO_0000259", "start_pos": 588, "end_pos": 880, "start_aa": "Leu", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 304, "end_pos": 306 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 763, "end_pos": 765 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIK7-1", "uniprot_ac": "A0AAA9SIK7", "uniprot_id": "A0AAA9SIK7_BOVIN", "mass": { "chemical_mass": 132329.0, "monoisotopic_mass": 132329.0 }, "refseq": {}, "gene_names": [ { "name": "NEK10", "type": "recommended", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase Nek10", "type": "recommended", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7/entry#names_and_taxonomy" } ] }, { "name": "Never in mitosis A-related kinase 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEK10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7", "locus": { "chromosome": "22", "start_pos": 1485805, "end_pos": 1746705, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000220", "url": "https://www.ensembl.org/id/ENSBTAG00000000220" } ] } } ], "crossref": [ { "id": "A0AAA9SIK7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000220", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000220", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08528", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08528", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3N110", "url": "https://www.orthodb.org/?gene=G3N110", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43671", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43671", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43671:SF92", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43671:SF92", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N110", "url": "https://www.uniprot.org/uniprotkb/G3N110", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N110-1", "url": "https://www.uniprot.org/uniprotkb/G3N110-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPDQDKKVKATEKSTDKKQQGVSIRDYSDLKRLLCLLNVQSSKQQLPAINFDSVQNSIMKSEPAVRTGGHRARGRWHESTEAVELENFSINYKNERNFSKHPQHKLFQEIFTALVKNRLICREWVDRAPSLHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVAHGYLGYGEAQHSVDKLVNMTYIFQKLAAVRDQREWVTTSGAHKTLVNLLSARDTNVLLGALLALASLAESPECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAERQVREQVKLYEGVPVLLSLLHSDHLKLLWSVVWILVQICEDPETSVEIRIWGGIKQLLHILRGDRNFVSDRSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLDDSNAHQVVQENGIYTIAKLILPNKQKNAAKTNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFETFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENVESINQNKAPSKYIGNYAIDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKRHHFAEERLWKIFIQLCLALRYLHKEKRIIHRDLTPNNIMLGDKDRVTVTDFGLAKQKQESSRLTSVVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLDPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVITTISRCLTPDAETRPDIVEVSSMISDIMMKYVDNLSTSQLALEKKLERERRRTQRYFMEANRNAIICQQEPTLLSQETFEKASLSSSSSGAGSLKSELSEITDLPAEGFQAPCVKDEDRTCDGLLSDDNFNLENIEKDLYSELDDELDVSDNFSSSGSSPLKESTFSTLKRSFSASGGERQSQTRDFTGGIGSRLRPALLPLDLLLKVPPLLLSAHVKEVEAELVTGWQSHSLPTVILHSLKHHGPQISAGIAVSQRKVRQISDPIQQILIQLHKVIYITQLPPALHHNLKRRIIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHHSLGGKSLSSNDPTGLPSSFDLEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNYPTKR", "length": 1165, "header": "tr|A0AAA9SIK7-1|A0AAA9SIK7_BOVIN Isoform 1 of Serine/threonine-protein kinase Nek10 OS=Bos taurus OX=9913 GN=NEK10 PE=3 SV=1 CANONICAL=A0AAA9SIK7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7/entry#A0AAA9SIK7-1", "sequence": { "sequence": "MPDQDKKVKATEKSTDKKQQGVSIRDYSDLKRLLCLLNVQSSKQQLPAINFDSVQNSIMKSEPAVRTGGHRARGRWHESTEAVELENFSINYKNERNFSKHPQHKLFQEIFTALVKNRLICREWVDRAPSLHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVAHGYLGYGEAQHSVDKLVNMTYIFQKLAAVRDQREWVTTSGAHKTLVNLLSARDTNVLLGALLALASLAESPECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAERQVREQVKLYEGVPVLLSLLHSDHLKLLWSVVWILVQICEDPETSVEIRIWGGIKQLLHILRGDRNFVSDRSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLDDSNAHQVVQENGIYTIAKLILPNKQKNAAKTNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFETFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENVESINQNKAPSKYIGNYAIDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKRHHFAEERLWKIFIQLCLALRYLHKEKRIIHRDLTPNNIMLGDKDRVTVTDFGLAKQKQESSRLTSVVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLDPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVITTISRCLTPDAETRPDIVEVSSMISDIMMKYVDNLSTSQLALEKKLERERRRTQRYFMEANRNAIICQQEPTLLSQETFEKASLSSSSSGAGSLKSELSEITDLPAEGFQAPCVKDEDRTCDGLLSDDNFNLENIEKDLYSELDDELDVSDNFSSSGSSPLKESTFSTLKRSFSASGGERQSQTRDFTGGIGSRLRPALLPLDLLLKVPPLLLSAHVKEVEAELVTGWQSHSLPTVILHSLKHHGPQISAGIAVSQRKVRQISDPIQQILIQLHKVIYITQLPPALHHNLKRRIIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHHSLGGKSLSSNDPTGLPSSFDLEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNYPTKR", "length": 1165, "header": "tr|A0AAA9SIK7-1|A0AAA9SIK7_BOVIN Isoform 1 of Serine/threonine-protein kinase Nek10 OS=Bos taurus OX=9913 GN=NEK10 PE=3 SV=1 CANONICAL=A0AAA9SIK7-1" }, "locus": { "chromosome": "22", "start_pos": 1723932, "end_pos": 1486703, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092582.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092582.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083591.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083591.1" } ] } }, { "isoform_ac": "A0AAA9SUM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7/entry#A0AAA9SUM0-1", "sequence": { "sequence": "MPDQDKKVKATEKSTDKKQQGVSIRDYSDLKRLLCLLNVQSSKQQLPAINFDSVQNSIMKSEPAVRTGGHRARGRWHESTEAVELENFSINYKNERNFSKHPQHKLFQEIFTALVKNRLICREWVDRAPSLHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVAHGYLGYGEAQHSVDKLVNMTYIFQKLAAVRDQREWVTTSGAHKTLVNLLSARDTNVLLGALLALASLAESPECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAERQVREQVKLYEGVPVLLSLLHSDHLKLLWSVVWILVQICEDPETSVEIRIWGGIKQLLHILRGDRNFVSDRSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLDDSNAHQVVQENGIYTIAKLILPNKQKNAAKTNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFETFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENVESINQNKAPSKYIGNYAIDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKRHHFAEERLWKIFIQLCLALRYLHKEKRIIHRDLTPNNIMLGDKDRVTVTDFGLAKQKQESSRLTSVVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLDPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVITTISRCLTPDAETRPDIVEVSSMISDIMMKYVDNLSTSQLALEKKLERERRRTQRYFMEANRNAIICQQEPTLLSQETFEKASLSSSSSGAGSLKSELSEITDLPAEGFQAPCVKDEDRTCDGLLSDDNFNLENIEKDLYSELDDELDVSDNFSSSGSSPLKESTFSTLKRSFSASGGERQSQTRDFTGGIGSRLRPASAGIAVSQRKVRQISDPIQQILIQLHKVIYITQLPPALHHNLKRRIIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHHSLGGKSLSSNDPTGLPSSFDLEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNYPTKR", "length": 1115, "header": "tr|A0AAA9SUM0-1|A0AAA9SUM0_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek10 OS=Bos taurus OX=9913 GN=NEK10 PE=3 SV=1 CANONICAL=A0AAA9SIK7-1" }, "locus": { "chromosome": "22", "start_pos": 1723932, "end_pos": 1486703, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095969.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095969.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087669.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087669.1" } ] } }, { "isoform_ac": "G3N110-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7/entry#G3N110-1", "sequence": { "sequence": "MKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKRHHFAEERLWKIFIQLCLALRYLHKEKRIIHRDLTPNNIMLGDKDRVTVTDFGLAKQKQESSRLTSVVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLDPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVITTISRCLTPDAETRPDIVEVSSMISDIMMKYVDNLSTSQLALEKKLERERRRTQRYFMEANRNAIICQQEPTLLSQETFEKASLSSSSSGAGSLKSELSEITDLPAEGFQAPCVKDEDRTCDGLLSDDNFNLENIEKDLYSELDDELDVSDNFSSSGSSPLKESTFSTLKRSFSASGGERQSQTRDFTGGIGSRLRPALLPLDLLLKVPPLLLSAHVKEVEAELVTGWQSHSLPTVILHSLKHHASAGIAVSQRKVRQISDPIQQILIQLHKVIYITQLPPALHHNLKRRIIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHHSLGGKSLSSNDPTGLPSSFDLEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNYPTKR", "length": 616, "header": "tr|G3N110-1|G3N110_BOVIN Computationally mapped isoform of NIMA related kinase 10 OS=Bos taurus OX=9913 GN=NEK10 PE=4 SV=3 CANONICAL=A0AAA9SIK7-1" }, "locus": { "chromosome": "22", "start_pos": 1645344, "end_pos": 1486703, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065772.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065772.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055532.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055532.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1145, "end_pos": 1147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 793, "end_pos": 795, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" }, { "start_pos": 911, "end_pos": 913, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 519, "end_pos": 791, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1145, "end_pos": 1147 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 793, "end_pos": 795 }, { "start_pos": 87, "end_pos": 89 }, { "start_pos": 911, "end_pos": 913 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIL3-1", "uniprot_ac": "A0AAA9SIL3", "uniprot_id": "A0AAA9SIL3_BOVIN", "mass": { "chemical_mass": 71887.0, "monoisotopic_mass": 71887.0 }, "refseq": {}, "gene_names": [ { "name": "NFE2L2", "type": "recommended", "evidence": [ { "id": "A0AAA9SIL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ] } ], "protein_names": [ { "name": "NFE2 like bZIP transcription factor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SIL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFE2L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3", "locus": { "chromosome": "2", "start_pos": 19649649, "end_pos": 19617075, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019255", "url": "https://www.ensembl.org/id/ENSBTAG00000019255" } ] } } ], "crossref": [ { "id": "A0AAA9SIL3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIL3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14720", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14720", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "497024", "url": "https://www.ncbi.nlm.nih.gov/gene/497024", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DMEEMDQ", "url": "https://omabrowser.org/oma/group/DMEEMDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTP2", "url": "https://www.orthodb.org/?gene=A0A3Q1LTP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24411:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24411:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03131", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03131", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9759194", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9759194", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9762114", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762114", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKH3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKH3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKR6", "url": "https://www.uniprot.org/uniprotkb/F1MKR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKR6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKR6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCFANTSGDRSCKESADWQAGTRGTQVLSWQQETGGLNRWPTSYLLKLPDMDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVAPIPKADDLYFDDCMQLLAETFPFVDDNEVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKRPDIKKN", "length": 642, "header": "tr|A0AAA9SIL3-1|A0AAA9SIL3_BOVIN Isoform 1 of NFE2 like bZIP transcription factor 2 OS=Bos taurus OX=9913 GN=NFE2L2 PE=3 SV=1 CANONICAL=A0AAA9SIL3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3/entry#A0A3Q1LRK0-1", "sequence": { "sequence": "LFVISLPPYYQQWSKLCDMDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVAPIPKADDLYFDDCMQLLAETFPFVDDNEVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKRPDIKKN", "length": 609, "header": "tr|A0A3Q1LRK0-1|A0A3Q1LRK0_BOVIN Computationally mapped isoform of NFE2 like bZIP transcription factor 2 OS=Bos taurus OX=9913 GN=NFE2L2 PE=3 SV=2 CANONICAL=A0AAA9SIL3-1" }, "locus": { "chromosome": "2", "start_pos": 19649154, "end_pos": 19645438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081481.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081481.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059632.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059632.2" } ] } }, { "isoform_ac": "A0A3Q1LTP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3/entry#A0A3Q1LTP2-1", "sequence": { "sequence": "MDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKRPDIKKN", "length": 561, "header": "tr|A0A3Q1LTP2-1|A0A3Q1LTP2_BOVIN Computationally mapped isoform of NFE2 like bZIP transcription factor 2 OS=Bos taurus OX=9913 GN=NFE2L2 PE=3 SV=2 CANONICAL=A0AAA9SIL3-1" }, "locus": { "chromosome": "2", "start_pos": 19649154, "end_pos": 19645558, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072818.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072818.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060452.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060452.2" } ] } }, { "isoform_ac": "A0AAA9SIL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3/entry#A0AAA9SIL3-1", "sequence": { "sequence": "MKCFANTSGDRSCKESADWQAGTRGTQVLSWQQETGGLNRWPTSYLLKLPDMDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVAPIPKADDLYFDDCMQLLAETFPFVDDNEVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKRPDIKKN", "length": 642, "header": "tr|A0AAA9SIL3-1|A0AAA9SIL3_BOVIN Isoform 1 of NFE2 like bZIP transcription factor 2 OS=Bos taurus OX=9913 GN=NFE2L2 PE=3 SV=1 CANONICAL=A0AAA9SIL3-1" }, "locus": { "chromosome": "2", "start_pos": 19649154, "end_pos": 19637110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135424.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135424.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085163.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085163.1" } ] } }, { "isoform_ac": "A0ABI0NKH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3/entry#A0ABI0NKH3-1", "sequence": { "sequence": "QDMDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVAPIPKADDLYFDDCMQLLAETFPFVDDNEVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKRPDIKKN", "length": 593, "header": "tr|A0ABI0NKH3-1|A0ABI0NKH3_BOVIN Computationally mapped isoform of NFE2 like bZIP transcription factor 2 OS=Bos taurus OX=9913 GN=NFE2L2 PE=3 SV=1 CANONICAL=A0AAA9SIL3-1" }, "locus": { "chromosome": "2", "start_pos": 19649154, "end_pos": 19645552, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153341.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153341.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105234.1" } ] } }, { "isoform_ac": "F1MKR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3/entry#F1MKR6-1", "sequence": { "sequence": "MDLIDILWRQDIDLGVSREVFDFSQRQKEHELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIPSETSGSANYSQVAPIPKADDLYFDDCMQLLAETFPFVDDNEVSSATFQSLVPDIPSHIESPVFTAPPQAQSPETLIVQVATAVLDDMQDIEQVWEELLSIPELQCLNIQNDKLAETSTVPSPETKLTEIDNYHFYSSMPSLDKEVGNCSPHFLNAFEDSFNSILSTEDSSQLTVNSLNSSATVNTDFGDEFYSAFIAEPSTSNGMPSSATLSQSLSELLNGPIDLSDLSLCKAFNQNHPESTTAEFNDSDSGISLNTTSPSMASPDHSVESSIYGDTLLGFSDSEMEEIDSTPGNVKQKGPKTPSVWPPGDPVQPLSSSQGNSAAARDSQCENAPKKEVPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVEDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKERGENDKSLHLLKKQLSTLYLEVFSMLRDENGKPYSPSEYSLQQTSDGNVFLVPKSKRPDIKKN", "length": 591, "header": "tr|F1MKR6-1|F1MKR6_BOVIN Computationally mapped isoform of NFE2 like bZIP transcription factor 2 OS=Bos taurus OX=9913 GN=NFE2L2 PE=3 SV=2 CANONICAL=A0AAA9SIL3-1" }, "locus": { "chromosome": "2", "start_pos": 19649154, "end_pos": 19645558, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025637.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025637.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025637.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025637.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9755511", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" }, { "id": "R-BTA-9759194", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9759194", "resource": "Reactome", "description": "Nuclear events mediated by NFE2L2" }, { "id": "R-BTA-9762114", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762114", "resource": "Reactome", "description": "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LI36-1", "protein_name": "Nuclear factor erythroid 2-related factor 2 isoform X1", "gene_name": "Nfe2l2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDASGSASYSQVTHIPKPDALYFEDCMQLLAETFPFVDDHEVSSPTFQSLTLDISSNVESPVFSSPDQAQSLDSCLETAMTDLNSIQQDMEQVWQELLSIPELQCLNTENKPLVETATVPSPEANLTEIDSNYHFYSSVPSLDKEVDSCSPHFLHGFEDSFGSILSTEDASQLTSLDSNSTLNTDFGDEFYSAFIAEPSGSSSMASSAAVSQSLSELLGGPIDGCDLSLCKAFNQKHPESTAEFNDSDSGISLNTSPSRASPEHSAESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPTHSSGDTVQPLSPALGHSPPAHDAQCENTTKKEMPVSPGHQKVPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRQLSTLYLEVFSMLRDEDGNPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN", "length": 604 }, "evidence": [ { "id": "A0AAA9SIL3", "url": "https://omabrowser.org/oma/group/A0AAA9SIL3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O54968-1", "protein_name": "Nuclear factor erythroid 2-related factor 2", "gene_name": "Nfe2l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDTSGSVSYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHEVSSPTFQSLALDIPSHVESSVFTTPDQAQSLDSSLETAMTDLSSIQQDMEQVWQELFSIPELQCLNTENKQQAETTTVPSPEATLTEMDSNYHFYSSIPSLEKEVDSCSPHFLHGFEDSFSSILSTDDASQLNSLDSNPTLNTDFGDEFYSAFLAEPSGGGSMPSSAAISQSLSELLGGPIEGCDLSLCKAFNQKHTEGTVEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPTHSSGDTVQPLSPAQGHSAAVHESQCENTTKKEVPVSPGHQKVPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRKLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN", "length": 604 }, "evidence": [ { "id": "A0AAA9SIL3", "url": "https://omabrowser.org/oma/group/A0AAA9SIL3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q16236-1", "protein_name": "Nuclear factor erythroid 2-related factor 2", "gene_name": "NFE2L2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN", "length": 605 }, "evidence": [ { "id": "A0AAA9SIL3", "url": "https://omabrowser.org/oma/group/A0AAA9SIL3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q60795-1", "protein_name": "Nuclear factor erythroid 2-related factor 2", "gene_name": "Nfe2l2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQFQLDEETGEFLPIQPAQHIQTDTSGSASYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHESLALDIPSHAESSVFTAPHQAQSLNSSLEAAMTDLSSIEQDMEQVWQELFSIPELQCLNTENKQLADTTAVPSPEATLTEMDSNYHFYSSISSLEKEVGNCGPHFLHGFEDSFSSILSTDDASQLTSLDSNPTLNTDFGDEFYSAFIAEPSDGGSMPSSAAISQSLSELLDGTIEGCDLSLCKAFNPKHAEGTMEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPAHSPGDTVQPLSPAQGHSAPMRESQCENTTKKEVPVSPGHQKAPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRRLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN", "length": 597 }, "evidence": [ { "id": "A0AAA9SIL3", "url": "https://omabrowser.org/oma/group/A0AAA9SIL3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "negative regulation of hematopoietic stem cell differentiation", "id": "GO:1902037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "positive regulation of glutathione biosynthetic process", "id": "GO:1903788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903788", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell apoptotic process", "id": "GO:2000352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "positive regulation of reactive oxygen species metabolic process", "id": "GO:2000379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000379", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cellular response to glucose starvation", "id": "GO:0042149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cell redox homeostasis", "id": "GO:0045454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045454", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "positive regulation of blood coagulation", "id": "GO:0030194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030194", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "positive regulation of D-glucose import", "id": "GO:0046326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046326", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway", "id": "GO:1902176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "PERK-mediated unfolded protein response", "id": "GO:0036499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036499", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cellular response to laminar fluid shear stress", "id": "GO:0071499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071499", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "regulation of removal of superoxide radicals", "id": "GO:2000121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "regulation of innate immune response", "id": "GO:0045088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "proteasomal ubiquitin-independent protein catabolic process", "id": "GO:0010499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010499", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "negative regulation of ferroptosis", "id": "GO:0110076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "protein-DNA complex", "id": "GO:0032993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "molecular condensate scaffold activity", "id": "GO:0140693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL3" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 534, "end_pos": 597, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIM7-1", "uniprot_ac": "A0AAA9SIM7", "uniprot_id": "A0AAA9SIM7_BOVIN", "mass": { "chemical_mass": 2949.0, "monoisotopic_mass": 2949.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "LASP1 neighbor", "type": "synonym", "evidence": [ { "id": "A0AAA9SIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SIM7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SIM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDIFILMFFAIIGLVILSYIIYLL", "length": 25, "header": "tr|A0AAA9SIM7-1|A0AAA9SIM7_BOVIN Isoform 1 of LASP1 neighbor OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIM7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM7/entry#A0AAA9SIM7-1", "sequence": { "sequence": "MLDIFILMFFAIIGLVILSYIIYLL", "length": 25, "header": "tr|A0AAA9SIM7-1|A0AAA9SIM7_BOVIN Isoform 1 of LASP1 neighbor OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIM7-1" }, "locus": { "chromosome": "19", "start_pos": 39497353, "end_pos": 39497279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087525.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087525.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083777.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083777.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIN7-1", "uniprot_ac": "A0AAA9SIN7", "uniprot_id": "A0AAA9SIN7_BOVIN", "mass": { "chemical_mass": 29387.0, "monoisotopic_mass": 29387.0 }, "refseq": { "ac": "XP_024842544", "name": "leucine-rich repeat-containing protein 18 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842544" }, "gene_names": [ { "name": "LRRC18", "type": "recommended", "evidence": [ { "id": "A0AAA9SIN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7" } ] }, { "name": "LRRC18", "type": "synonym", "evidence": [ { "id": "XP_024842544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842544" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 18", "type": "recommended", "evidence": [ { "id": "A0AAA9SIN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 18 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024842544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842544" } ] } ], "function": [ { "annotation": "May be involved in the regulation of spermatogenesis and sperm maturation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7#function" }, { "database": "UniProtKB", "id": "ARBA00059537", "url": "https://www.uniprot.org/uniprotkb/ARBA00059537#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7", "locus": { "chromosome": "28", "start_pos": 43211154, "end_pos": 43231590, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005996", "url": "https://www.ensembl.org/id/ENSBTAG00000005996" } ] } } ], "crossref": [ { "id": "A0AAA9SIN7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "767998", "url": "https://www.ncbi.nlm.nih.gov/gene/767998", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842544", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842544", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKGAKGPKGKKITLAVAKNCIKITFDGKKRLDLSKMGITTFPKCILRLTDVDELDLSRNLIKKIPDAISKFQNLRWLDLHSNYIDKLPETIGQMTSLLYLNVSNNRLTTNGLPVELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLSNIPNSISKLPKLKKLNTKRNPFPKAESSDMFMDSIRRLDNLHLVEEKDLCGTCLKKCQQARDKLNKIKSMATTIPRKAIFSTLVSPNSMAKESQEDWRMRSTSP", "length": 261, "header": "tr|A0AAA9SIN7-1|A0AAA9SIN7_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 18 OS=Bos taurus OX=9913 GN=LRRC18 PE=4 SV=1 CANONICAL=A0AAA9SIN7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7/entry#A0AAA9SIN7-1", "sequence": { "sequence": "MAKGAKGPKGKKITLAVAKNCIKITFDGKKRLDLSKMGITTFPKCILRLTDVDELDLSRNLIKKIPDAISKFQNLRWLDLHSNYIDKLPETIGQMTSLLYLNVSNNRLTTNGLPVELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLSNIPNSISKLPKLKKLNTKRNPFPKAESSDMFMDSIRRLDNLHLVEEKDLCGTCLKKCQQARDKLNKIKSMATTIPRKAIFSTLVSPNSMAKESQEDWRMRSTSP", "length": 261, "header": "tr|A0AAA9SIN7-1|A0AAA9SIN7_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 18 OS=Bos taurus OX=9913 GN=LRRC18 PE=4 SV=1 CANONICAL=A0AAA9SIN7-1" }, "locus": { "chromosome": "28", "start_pos": 43215390, "end_pos": 43211231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091544.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091544.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083630.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083630.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN7" }, { "id": "PF23598", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Disease resistance R13L4/SHOC-2-like LRR", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 129, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIN9-1", "uniprot_ac": "A0AAA9SIN9", "uniprot_id": "A0AAA9SIN9_BOVIN", "mass": { "chemical_mass": 16669.0, "monoisotopic_mass": 16669.0 }, "refseq": {}, "gene_names": [ { "name": "IFT25", "type": "recommended", "evidence": [ { "id": "A0AAA9SIN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" } ] } ], "protein_names": [ { "name": "Intraflagellar transport protein 25 homolog", "type": "recommended", "evidence": [ { "id": "A0AAA9SIN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#names_and_taxonomy" } ] }, { "name": "Heat shock protein beta-11", "type": "synonym", "evidence": [ { "id": "A0AAA9SIN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#names_and_taxonomy" } ] }, { "name": "Placental protein 25", "type": "synonym", "evidence": [ { "id": "A0AAA9SIN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9#function" }, { "database": "UniProtKB", "id": "ARBA00058003", "url": "https://www.uniprot.org/uniprotkb/ARBA00058003#function" }, { "database": "UniProtKB", "id": "A0AAA9SSY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY3#function" }, { "database": "UniProtKB", "id": "A0ABI0NQ29", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ29#function" }, { "database": "UniProtKB", "id": "A0ABI0P0T5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0T5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9", "locus": { "chromosome": "3", "start_pos": 92296401, "end_pos": 92262391, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007112", "url": "https://www.ensembl.org/id/ENSBTAG00000007112" } ] } } ], "crossref": [ { "id": "A0AAA9SIN9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "616194", "url": "https://www.ncbi.nlm.nih.gov/gene/616194", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33906", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33906", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33906:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33906:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ29", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ29-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0T5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0T5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0T5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0T5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P112", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P112", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P112-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P112-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKVDLCLSSEGTEVIFATSSDEKHPPENMIDGNPETFWTTTGMFPQEFIICFHKHVRIEKLVIQSYFVRTLRIEKSTSKEPVDFEQWIERDLVHTEGQLQNEEILVSKYTLKIYTLSLASTMYLNFKPISIIIKLLNTLVIL", "length": 143, "header": "tr|A0AAA9SIN9-1|A0AAA9SIN9_BOVIN Isoform 1 of Intraflagellar transport protein 25 homolog OS=Bos taurus OX=9913 GN=IFT25 PE=3 SV=1 CANONICAL=A0AAA9SIN9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#A0AAA9SIN9-1", "sequence": { "sequence": "MRKVDLCLSSEGTEVIFATSSDEKHPPENMIDGNPETFWTTTGMFPQEFIICFHKHVRIEKLVIQSYFVRTLRIEKSTSKEPVDFEQWIERDLVHTEGQLQNEEILVSKYTLKIYTLSLASTMYLNFKPISIIIKLLNTLVIL", "length": 143, "header": "tr|A0AAA9SIN9-1|A0AAA9SIN9_BOVIN Isoform 1 of Intraflagellar transport protein 25 homolog OS=Bos taurus OX=9913 GN=IFT25 PE=3 SV=1 CANONICAL=A0AAA9SIN9-1" }, "locus": { "chromosome": "3", "start_pos": 92293901, "end_pos": 92272933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088609.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088609.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083787.1" } ] } }, { "isoform_ac": "A0AAA9SSY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#A0AAA9SSY3-1", "sequence": { "sequence": "MKVKSESEVAQSCPTLGHLMDCSLPGSPSMGFSRQEYWCGLPLPSPLVAIGDTAFVVNLHLYIASCPITSRSSRKIKHFKMRKVDLCLSSEGTEVIFATSSDEKHPPENMIDGNPETFWTTTGMFPQEFIICFHKHVRIEKLVIQSYFVRTLRIEKSTSKEPVDFEQWIERDLVHTEGQLQNEEILARDGHVTYLRFIIVSAFDHFASVHSVSAEGVAVSNLS", "length": 223, "header": "tr|A0AAA9SSY3-1|A0AAA9SSY3_BOVIN Computationally mapped isoform of Intraflagellar transport protein 25 homolog OS=Bos taurus OX=9913 GN=IFT25 PE=3 SV=1 CANONICAL=A0AAA9SIN9-1" }, "locus": { "chromosome": "3", "start_pos": 92296312, "end_pos": 92263944, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135355.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135355.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089521.1" } ] } }, { "isoform_ac": "A0ABI0NQ29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#A0ABI0NQ29-1", "sequence": { "sequence": "MRKVDLCLSSEGTEVIFATSSDEKHPPENMIDGNPETFWTTTGMFPQEFIICFHKHVRIEKLVIQSYFVRTLRIEKSTSKEPVDFEQWIERDLVHTEGQLQNEEILVRNKIGHCVEIQDISESPVSASIIICHSFCVSLYHLPSMHIFFCVFSSYKDNIMLN", "length": 162, "header": "tr|A0ABI0NQ29-1|A0ABI0NQ29_BOVIN Computationally mapped isoform of Intraflagellar transport protein 25 homolog OS=Bos taurus OX=9913 GN=IFT25 PE=3 SV=1 CANONICAL=A0AAA9SIN9-1" }, "locus": { "chromosome": "3", "start_pos": 92297460, "end_pos": 92272933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152693.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152693.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104263.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104263.1" } ] } }, { "isoform_ac": "A0ABI0P0T5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#A0ABI0P0T5-1", "sequence": { "sequence": "MRTAHTAFVVNLHLYIASCPITSRSSRKIKHFKMRKVDLCLSSEGTEVIFATSSDEKHPPENMIDGNPETFWTTTGMFPQEFIICFHKHVRIEKLVIQSYFVRTLRIEKSTSKEPVDFEQWIERDLVHTEGQLQNEEILARDGHVTYLRFIIVSAFDHFASVHSVSAEGVAVSNLS", "length": 176, "header": "tr|A0ABI0P0T5-1|A0ABI0P0T5_BOVIN Computationally mapped isoform of Intraflagellar transport protein 25 homolog OS=Bos taurus OX=9913 GN=IFT25 PE=3 SV=1 CANONICAL=A0AAA9SIN9-1" }, "locus": { "chromosome": "3", "start_pos": 92296312, "end_pos": 92262475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152082.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152082.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104463.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104463.1" } ] } }, { "isoform_ac": "A0ABI0P112-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9/entry#A0ABI0P112-1", "sequence": { "sequence": "MRKVDLCLSSEGTEVIFATSSDEKHPPENMIDGNPETFWTTTGMFPQEFIICFHKHVRIEKLVIQSYFGK", "length": 70, "header": "tr|A0ABI0P112-1|A0ABI0P112_BOVIN Computationally mapped isoform of Intraflagellar transport 25 OS=Bos taurus OX=9913 GN=IFT25 PE=4 SV=1 CANONICAL=A0AAA9SIN9-1" }, "locus": { "chromosome": "3", "start_pos": 92286784, "end_pos": 92272933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144762.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144762.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104264.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104264.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" } ], "pmid": "" }, { "name": "intraciliary transport particle B", "id": "GO:0030992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIN9" }, { "id": "PF00754", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00754" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F5/8 type C", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 80, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIP4-1", "uniprot_ac": "A0AAA9SIP4", "uniprot_id": "A0AAA9SIP4_BOVIN", "mass": { "chemical_mass": 22924.0, "monoisotopic_mass": 22924.0 }, "refseq": {}, "gene_names": [ { "name": "SIVA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SIP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4" } ] } ], "protein_names": [ { "name": "SIVA1 apoptosis inducing factor", "type": "synonym", "evidence": [ { "id": "A0AAA9SIP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SIVA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4", "locus": { "chromosome": "21", "start_pos": 69230630, "end_pos": 69222002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017622", "url": "https://www.ensembl.org/id/ENSBTAG00000017622" } ] } } ], "crossref": [ { "id": "A0AAA9SIP4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017622", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017622", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR022773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3X7B3", "url": "https://www.orthodb.org/?gene=G3X7B3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14365", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14365", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14365:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14365:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05458", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05458", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X7B3", "url": "https://www.uniprot.org/uniprotkb/G3X7B3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X7B3-1", "url": "https://www.uniprot.org/uniprotkb/G3X7B3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKRGYPFADAAPLQLKVRVGQRELSRGVCAERLTREIFEKTMQLLFRGAQACMDPAWEEGCAIVHTPESPRPGPTEAPRAARGQMLIGPDGRLTRSQAQASEADPAGVASRACSSCVRAVDGKAACGQCERALCARCVRTCCSCGAVACALCALVDYGGAQGAATAPAEGAGQGRGNSGSEASRRTSATGGSHRRDGPSGKGVQGGLSPEIRNPSTHRQR", "length": 221, "header": "tr|A0AAA9SIP4-1|A0AAA9SIP4_BOVIN Isoform 1 of SIVA1 apoptosis inducing factor OS=Bos taurus OX=9913 GN=SIVA1 PE=4 SV=1 CANONICAL=A0AAA9SIP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4/entry#A0AAA9SIP4-1", "sequence": { "sequence": "MPKRGYPFADAAPLQLKVRVGQRELSRGVCAERLTREIFEKTMQLLFRGAQACMDPAWEEGCAIVHTPESPRPGPTEAPRAARGQMLIGPDGRLTRSQAQASEADPAGVASRACSSCVRAVDGKAACGQCERALCARCVRTCCSCGAVACALCALVDYGGAQGAATAPAEGAGQGRGNSGSEASRRTSATGGSHRRDGPSGKGVQGGLSPEIRNPSTHRQR", "length": 221, "header": "tr|A0AAA9SIP4-1|A0AAA9SIP4_BOVIN Isoform 1 of SIVA1 apoptosis inducing factor OS=Bos taurus OX=9913 GN=SIVA1 PE=4 SV=1 CANONICAL=A0AAA9SIP4-1" }, "locus": { "chromosome": "21", "start_pos": 69229970, "end_pos": 69222052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121060.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121060.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083792.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083792.1" } ] } }, { "isoform_ac": "G3X7B3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4/entry#G3X7B3-1", "sequence": { "sequence": "MPKRGYPFADAAPLQLKVRVGQRELSRGVCAERLTREIFDPAGVASRACSSCVRAVDGKAACGQCERALCARCVRTCCSCGAVACALCALVDYGGDLHEKVLCSSCAAFEA", "length": 111, "header": "tr|G3X7B3-1|G3X7B3_BOVIN Computationally mapped isoform of SIVA1 apoptosis inducing factor OS=Bos taurus OX=9913 GN=SIVA1 PE=4 SV=2 CANONICAL=A0AAA9SIP4-1" }, "locus": { "chromosome": "21", "start_pos": 69226267, "end_pos": 69222052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023435.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023435.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023435.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023435.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 76, "start_aa": "Thr", "end_pos": 76, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr76", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "CD27 receptor binding", "id": "GO:0005175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 76 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIP8-1", "uniprot_ac": "A0AAA9SIP8", "uniprot_id": "A0AAA9SIP8_BOVIN", "mass": { "chemical_mass": 33922.0, "monoisotopic_mass": 33922.0 }, "refseq": {}, "gene_names": [ { "name": "OR5B140", "type": "recommended", "evidence": [ { "id": "A0AAA9SIP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SIP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5B140", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SIP8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15407", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15407", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FMENNTETADFILLGLTDDPQLQVPLFIAFTFIYLLTLIGNLGMTTLILLDSRLHIPMYFFLSNLSLVDFCYSSTITPKVMAGLLIGDKTMSYRACAAQMFFFVAFATVENYLLASMAYDRYAAVCKPLHYTTTMTTSVCARLAIGSHIFGLLTAAIDAGDTFCLSFCTSNVIHHFFCDIPAVMSLTCSDKGINELILFLISSFNIFFALLVILISYLLIFITILKLQSGEGYQKALSTCASHLVAVSIFYGTVIFMYLQPSSSHSMDRDKIASVFYTILIPMLNPVVYSLRNREVKNAFKKVI", "length": 304, "header": "tr|A0AAA9SIP8-1|A0AAA9SIP8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5B140 PE=3 SV=1 CANONICAL=A0AAA9SIP8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8/entry#A0AAA9SIP8-1", "sequence": { "sequence": "FMENNTETADFILLGLTDDPQLQVPLFIAFTFIYLLTLIGNLGMTTLILLDSRLHIPMYFFLSNLSLVDFCYSSTITPKVMAGLLIGDKTMSYRACAAQMFFFVAFATVENYLLASMAYDRYAAVCKPLHYTTTMTTSVCARLAIGSHIFGLLTAAIDAGDTFCLSFCTSNVIHHFFCDIPAVMSLTCSDKGINELILFLISSFNIFFALLVILISYLLIFITILKLQSGEGYQKALSTCASHLVAVSIFYGTVIFMYLQPSSSHSMDRDKIASVFYTILIPMLNPVVYSLRNREVKNAFKKVI", "length": 304, "header": "tr|A0AAA9SIP8-1|A0AAA9SIP8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5B140 PE=3 SV=1 CANONICAL=A0AAA9SIP8-1" }, "locus": { "chromosome": "15", "start_pos": 81569635, "end_pos": 81568724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109605.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109605.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083798.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083798.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 }, { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIS9-1", "uniprot_ac": "A0AAA9SIS9", "uniprot_id": "A0AAA9SIS9_BOVIN", "mass": { "chemical_mass": 28056.0, "monoisotopic_mass": 28056.0 }, "refseq": { "ac": "XP_002696258", "name": "CMRF35-like molecule 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696258" }, "gene_names": [ { "name": "CD300E", "type": "recommended", "evidence": [ { "id": "A0AAA9SIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9" } ] }, { "name": "CD300E", "type": "synonym", "evidence": [ { "id": "XP_002696258", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696258" } ] } ], "protein_names": [ { "name": "CD300e molecule", "type": "synonym", "evidence": [ { "id": "A0AAA9SIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9/entry#names_and_taxonomy" } ] }, { "name": "CMRF35-like molecule 2", "type": "synonym", "evidence": [ { "id": "XP_002696258", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696258" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD300E", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9", "locus": { "chromosome": "19", "start_pos": 56779893, "end_pos": 56769740, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058003", "url": "https://www.ensembl.org/id/ENSBTAG00000058003" } ] } } ], "crossref": [ { "id": "A0AAA9SIS9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524761", "url": "https://www.ncbi.nlm.nih.gov/gene/524761", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524761", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524761", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WCRIQTV", "url": "https://omabrowser.org/oma/group/WCRIQTV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11860:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11860:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696258", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696258", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLPSALLLLCLPGCWSLTGPSSVAGTMGSSLHVRCQYEKAYKGHNKYWCRGKYGTVCRKIVETKGEEKERRNGRVSIRDQADNLTFTVIMENLSTNDAGSYWCRIQTVWILDVLSWDPSVQVEVSVSPAPSTTPGSTACLAVPASPPTVNDGQNLSAKEISTGCPGSELSNVHFLLLVFLKLPLFLGMVGAVLWVNRPQRRPGGRKRQLDQGGRPCSVLSPGMPCPGIQLFRLDKRDLQILGSRAGGQQLLDSGRT", "length": 257, "header": "tr|A0AAA9SIS9-1|A0AAA9SIS9_BOVIN Isoform 1 of CD300e molecule OS=Bos taurus OX=9913 GN=CD300E PE=4 SV=1 CANONICAL=A0AAA9SIS9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9/entry#A0AAA9SIS9-1", "sequence": { "sequence": "MWLPSALLLLCLPGCWSLTGPSSVAGTMGSSLHVRCQYEKAYKGHNKYWCRGKYGTVCRKIVETKGEEKERRNGRVSIRDQADNLTFTVIMENLSTNDAGSYWCRIQTVWILDVLSWDPSVQVEVSVSPAPSTTPGSTACLAVPASPPTVNDGQNLSAKEISTGCPGSELSNVHFLLLVFLKLPLFLGMVGAVLWVNRPQRRPGGRKRQLDQGGRPCSVLSPGMPCPGIQLFRLDKRDLQILGSRAGGQQLLDSGRT", "length": 257, "header": "tr|A0AAA9SIS9-1|A0AAA9SIS9_BOVIN Isoform 1 of CD300e molecule OS=Bos taurus OX=9913 GN=CD300E PE=4 SV=1 CANONICAL=A0AAA9SIS9-1" }, "locus": { "chromosome": "19", "start_pos": 56778889, "end_pos": 56769871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113075.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113075.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083830.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 134, "start_aa": "Thr", "end_pos": 134, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr134", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:524761", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524761", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JNY5-1", "protein_name": "CMRF35-like molecule 2", "gene_name": "LOC100759375", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWLCPALLLLCLQGCSSLTGPGSVSGYVGGTVHVQCQYGKSYKDHVKYWCRGKSDTKCKTIVEIKGNGEVKKSGRVSMRDHAGNFSMTVTMENLSEDDAGSYWCKIQTFFIWDSWSRDPAVLVKVHVLPATTPMATTLAVTTASLPLVNTGHLRISTSESFLLQLWPLLSTIHFQILVLLKLPLFLSMLCAVFWVNRLQKIPGGN", "length": 205 }, "evidence": [ { "id": "A0AAA9SIS9", "url": "https://omabrowser.org/oma/group/A0AAA9SIS9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q496F6-1", "protein_name": "CMRF35-like molecule 2", "gene_name": "CD300E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWLLPALLLLCLSGCLSLKGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCESIVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSYWCKIQTVWVLDSWSRDPSDLVRVYVSPAITTPRRTTHPATPPIFLVVNPGRNLSTGEVLTQNSGFRLSSPHFLLVVLLKLPLLLSMLGAVFWVNRPQWAPPGR", "length": 205 }, "evidence": [ { "id": "A0AAA9SIS9", "url": "https://omabrowser.org/oma/group/A0AAA9SIS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K249-1", "protein_name": "CMRF35-like molecule 2", "gene_name": "Cd300e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLCAGLLLLCFQGCLSLTGPGSVSGYVGGSLRVQCQYSPSYKGYMKYWCRGPHDTTCKTIVETDGSEKEKRSGPVSIRDHASNSTITVIMEDLSEDNAGSYWCKIQTSFIWDSWSRDPSVSVRVNVFPATTPTLPATTAILPLVNSGQNLRISTNVMFIFQLWSLLSSIQFQVLVFLKLPLFLSMLCAIFWVNRL", "length": 196 }, "evidence": [ { "id": "A0AAA9SIS9", "url": "https://omabrowser.org/oma/group/A0AAA9SIS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIS9" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 128, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 134 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 84, "end_pos": 86 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIV1-1", "uniprot_ac": "A0AAA9SIV1", "uniprot_id": "A0AAA9SIV1_BOVIN", "mass": { "chemical_mass": 57028.0, "monoisotopic_mass": 57028.0 }, "refseq": { "ac": "NP_001192951", "name": "nectin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" }, "gene_names": [ { "name": "NECTIN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ] }, { "name": "HVEC", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "NECTIN1", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "PVRL1", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "prr1", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] } ], "protein_names": [ { "name": "Nectin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9SIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1/entry#names_and_taxonomy" } ] }, { "name": "Herpes virus entry mediator C", "type": "synonym", "evidence": [ { "id": "A0AAA9SIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1/entry#names_and_taxonomy" } ] }, { "name": "Nectin cell adhesion molecule 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1/entry#names_and_taxonomy" } ] }, { "name": "Poliovirus receptor-related protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1/entry#names_and_taxonomy" } ] }, { "name": "herpesvirus entry mediator C", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "nectin-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "nectin", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "poliovirus receptor related protein", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] }, { "name": "poliovirus receptor-related 1 (herpesvirus entry mediator C)", "type": "synonym", "evidence": [ { "id": "NP_001192951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NECTIN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1", "locus": { "chromosome": "15", "start_pos": 30175407, "end_pos": 30282082, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015939", "url": "https://www.ensembl.org/id/ENSBTAG00000015939" } ] } } ], "crossref": [ { "id": "A0AAA9SIV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015939", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05886", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05886", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05890", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05890", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533492", "url": "https://www.ncbi.nlm.nih.gov/gene/533492", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6LSA", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6LSA&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533492", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533492", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVVNYHM", "url": "https://omabrowser.org/oma/group/CVVNYHM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQJ3", "url": "https://www.orthodb.org/?gene=F1MQJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23277", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23277", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23277:SF69", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23277:SF69", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006lsa", "url": "https://www.rcsb.org/structure/pdb_00006lsa", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6LSA", "url": "https://www.rcsb.org/structure/6LSA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420597", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420597", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQJ3", "url": "https://www.uniprot.org/uniprotkb/F1MQJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MQJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARMGLAGAAGRWWGLALGLTAFFLPGAQAQMVQVNDSMYGFIGTDVVLHCSFANPLPGVKITQVTWQKATNGSKQNVAIYNPAMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPAGNRESQLNLTVMAKPTNWIEGTHAVLRARKGQDEKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHMDRFWESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSLAGTYVCEATNPIGTRSAQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVVGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPEDSDDDKKAGPLGGSSYEEEEDEEGGGGERKVGGPHSKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV", "length": 515, "header": "tr|A0AAA9SIV1-1|A0AAA9SIV1_BOVIN Isoform 1 of Nectin-1 OS=Bos taurus OX=9913 GN=NECTIN1 PE=3 SV=1 CANONICAL=A0AAA9SIV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1/entry#A0AAA9SIV1-1", "sequence": { "sequence": "MARMGLAGAAGRWWGLALGLTAFFLPGAQAQMVQVNDSMYGFIGTDVVLHCSFANPLPGVKITQVTWQKATNGSKQNVAIYNPAMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPAGNRESQLNLTVMAKPTNWIEGTHAVLRARKGQDEKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHMDRFWESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSLAGTYVCEATNPIGTRSAQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVVGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPEDSDDDKKAGPLGGSSYEEEEDEEGGGGERKVGGPHSKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV", "length": 515, "header": "tr|A0AAA9SIV1-1|A0AAA9SIV1_BOVIN Isoform 1 of Nectin-1 OS=Bos taurus OX=9913 GN=NECTIN1 PE=3 SV=1 CANONICAL=A0AAA9SIV1-1" }, "locus": { "chromosome": "15", "start_pos": 30281883, "end_pos": 30213864, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112262.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112262.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085266.1" } ] } }, { "isoform_ac": "F1MQJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1/entry#F1MQJ3-1", "sequence": { "sequence": "MARMGLAGAAGRWWGLALGLTAFFLPGAQAQMVQVNDSMYGFIGTDVVLHCSFANPLPGVKITQVTWQKATNGSKQNVAIYNPAMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPAGNRESQLNLTVMAKPTNWIEGTHAVLRARKGQDEKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHMDRFWESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSLAGTYVCEATNPIGTRSAQVEVNITEKPLPRGGPGIMARLLGCAVAVALILSVASTVFLYHWQQKNRLEMDGGGTALPLSQEPEPSPSRQSHLALENIQILGLELEKQQLQQEEDEPQKLPPQPPYYDLGASPSYHPLSSGLKDTDVYYAELDTSALEVMSGPRSTMLGSEEVVEYATIQLSPP", "length": 493, "header": "tr|F1MQJ3-1|F1MQJ3_BOVIN Computationally mapped isoform of Nectin-1 OS=Bos taurus OX=9913 GN=NECTIN1 PE=1 SV=4 CANONICAL=A0AAA9SIV1-1" }, "locus": { "chromosome": "15", "start_pos": 30281883, "end_pos": 30175413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061522.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061522.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053311.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053311.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.", "journal": "Sci. Adv.", "date": "2020", "authors": "Yue Dan, Chen Zhujun, Yang Fanli, Ye Fei, Lin Sheng, He Bin, Cheng Yanwei, Wang Jichao, Chen Zimin, Lin Xi, Yang Jing, Chen Hua, Zhang Zhonglin, You Yu, Sun Honglu, Wen Ao, Wang Lingling, Zheng Yue, Cao Yu, Li Yuhua, Lu Guangwen", "evidence": [ { "database": "UniProtKB", "id": "F1MQJ3", "url": "https://www.uniprot.org/uniprotkb/F1MQJ3" } ], "reference": [ { "type": "PubMed", "id": "32426511", "url": "https://glygen.org/publication/PubMed/32426511" } ] } ], "pathway": [ { "id": "bta:533492", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533492", "resource": "KEGG Pathway" }, { "id": "R-BTA-418990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "resource": "Reactome", "description": "Adherens junctions interactions" }, { "id": "R-BTA-420597", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420597", "resource": "Reactome", "description": "Nectin/Necl trans heterodimerization" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S9T5-1", "protein_name": "Nectin-1", "gene_name": "NECTIN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARMGLAGAAGRWWGLALGLTAFFLPGAHTQVVQVNDSMYGFIGTDVVLHCSFANPLPGVKITQVTWQKATNGSKQNVAIYNPAMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPAGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGKDDKVLVATCTSANGKPPSVVSWETHLKGEAEYQEIRNPNGTVTVISRYRLVPSREDHRQSLACIVNYHMDRFRESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSMAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGQVPTAIIGGVVGSILLVLFVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPEDSDDEKKAGPLGGSSYEEEEEEEGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV", "length": 515 }, "evidence": [ { "id": "A0AAA9SIV1", "url": "https://omabrowser.org/oma/group/A0AAA9SIV1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "presynaptic active zone membrane", "id": "GO:0048787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "cell-cell contact zone", "id": "GO:0044291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044291", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "hippocampal mossy fiber to CA3 synapse", "id": "GO:0098686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098686", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "virus receptor activity", "id": "GO:0001618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001618", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "cell adhesion mediator activity", "id": "GO:0098631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "cochlea morphogenesis", "id": "GO:0090103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090103", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" }, { "name": "protein localization to cell junction", "id": "GO:1902414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902414", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 141, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 139, "end_pos": 141 }, { "start_pos": 202, "end_pos": 204 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SIV3-1", "uniprot_ac": "A0AAA9SIV3", "uniprot_id": "A0AAA9SIV3_BOVIN", "mass": { "chemical_mass": 2195.0, "monoisotopic_mass": 2195.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SIV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SIV3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SIV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DYGNRLTFGNGTRVLVTPSK", "length": 20, "header": "tr|A0AAA9SIV3-1|A0AAA9SIV3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIV3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV3/entry#A0AAA9SIV3-1", "sequence": { "sequence": "DYGNRLTFGNGTRVLVTPSK", "length": 20, "header": "tr|A0AAA9SIV3-1|A0AAA9SIV3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SIV3-1" }, "locus": { "chromosome": "10", "start_pos": 22278986, "end_pos": 22278927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123272.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123272.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083718.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083718.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 17, "start_aa": "Thr", "end_pos": 17, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 17 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SIW0-1", "uniprot_ac": "A0AAA9SIW0", "uniprot_id": "A0AAA9SIW0_BOVIN", "mass": { "chemical_mass": 14972.0, "monoisotopic_mass": 14972.0 }, "refseq": {}, "gene_names": [ { "name": "SMIM34", "type": "recommended", "evidence": [ { "id": "A0AAA9SIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 34", "type": "synonym", "evidence": [ { "id": "A0AAA9SIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0", "locus": { "chromosome": "1", "start_pos": 1076459, "end_pos": 1072002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057327", "url": "https://www.ensembl.org/id/ENSBTAG00000057327" } ] } } ], "crossref": [ { "id": "A0AAA9SIW0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SIW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "QSKVAKC", "url": "https://omabrowser.org/oma/group/QSKVAKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SIW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEWHWANQTQASRILGHLLGDHMEGRNSSNSTRALKLSDGTRAAWYILTIFGIYGLIFLFRLASNILRKNEKSLEDIYYSNLTFELEKKGLQSKAARCSSLTISHRAVLRPNQASPETKGGNSSPHAEIQEIP", "length": 133, "header": "tr|A0AAA9SIW0-1|A0AAA9SIW0_BOVIN Isoform 1 of Small integral membrane protein 34 OS=Bos taurus OX=9913 GN=SMIM34 PE=4 SV=1 CANONICAL=A0AAA9SIW0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIW0/entry#A0AAA9SIW0-1", "sequence": { "sequence": "MEWHWANQTQASRILGHLLGDHMEGRNSSNSTRALKLSDGTRAAWYILTIFGIYGLIFLFRLASNILRKNEKSLEDIYYSNLTFELEKKGLQSKAARCSSLTISHRAVLRPNQASPETKGGNSSPHAEIQEIP", "length": 133, "header": "tr|A0AAA9SIW0-1|A0AAA9SIW0_BOVIN Isoform 1 of Small integral membrane protein 34 OS=Bos taurus OX=9913 GN=SMIM34 PE=4 SV=1 CANONICAL=A0AAA9SIW0-1" }, "locus": { "chromosome": "1", "start_pos": 1076456, "end_pos": 1072002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109795.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109795.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083861.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A8MWV9-1", "protein_name": "Small integral membrane protein 34", "gene_name": "SMIM34", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEWAKWTPHEASNQTQASTLLGLLLGDHTEGRNDTNSTRALKVPDGTSAAWYILTIIGIYAVIFVFRLASNILRKNDKSLEDVYYSNLTSELKMTGLQGKVAKCSTLSISNRAVLQPCQAHLGAKGGSSGPQTATPETP", "length": 139 }, "evidence": [ { "id": "A0AAA9SIW0", "url": "https://omabrowser.org/oma/group/A0AAA9SIW0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 27, "end_pos": 29 }, { "start_pos": 30, "end_pos": 32 }, { "start_pos": 7, "end_pos": 9 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ06-1", "uniprot_ac": "A0AAA9SJ06", "uniprot_id": "A0AAA9SJ06_BOVIN", "mass": { "chemical_mass": 31765.0, "monoisotopic_mass": 31765.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Steroidogenic acute regulatory protein, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06/entry#names_and_taxonomy" } ] }, { "name": "START domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06/entry#names_and_taxonomy" } ] }, { "name": "StAR", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06#function" }, { "database": "UniProtKB", "id": "RU365007", "url": "https://www.uniprot.org/uniprotkb/RU365007#function" }, { "database": "UniProtKB", "id": "ARBA00060302", "url": "https://www.uniprot.org/uniprotkb/ARBA00060302#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJ06", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ06", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08905", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08905", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CMEAMGE", "url": "https://omabrowser.org/oma/group/CMEAMGE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46489:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46489:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "39747", "url": "https://www.rhea-db.org/rhea/39747", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLATFKLCAGSSYRHVRSMKGLQQQAVLAIGQELNRRALGGPAPAAWINQVRRRGSLLGSQLEDPLYSNQELAYIQQGEEAMQRALGILKDQEGWKKESRQANGDEVLSKVIPDVGKVFRLEVVVHQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAEAAGNLVGPRDFVSVGCTKRRGSMCVLAGMATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC", "length": 285, "header": "tr|A0AAA9SJ06-1|A0AAA9SJ06_BOVIN Isoform 1 of Steroidogenic acute regulatory protein, mitochondrial OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SJ06-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06/entry#A0AAA9SJ06-1", "sequence": { "sequence": "MLLATFKLCAGSSYRHVRSMKGLQQQAVLAIGQELNRRALGGPAPAAWINQVRRRGSLLGSQLEDPLYSNQELAYIQQGEEAMQRALGILKDQEGWKKESRQANGDEVLSKVIPDVGKVFRLEVVVHQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAEAAGNLVGPRDFVSVGCTKRRGSMCVLAGMATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC", "length": 285, "header": "tr|A0AAA9SJ06-1|A0AAA9SJ06_BOVIN Isoform 1 of Steroidogenic acute regulatory protein, mitochondrial OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SJ06-1" }, "locus": { "chromosome": "3", "start_pos": 6944368, "end_pos": 6943514, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115082.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115082.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085320.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q9DG10-1", "protein_name": "Steroidogenic acute regulatory protein, mitochondrial", "gene_name": "star", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLPATFKLCAGISYRHMRNMTGLRKNAMIAIHHELNKLSGPGASTWINHIRRRSSLLSSPIAEETYSEADQCYVQQGQEALQKSISILEDQDGWQTEIESINGEKVMSKVLPGIGKVFKLEVTLEQQTGDLYDELVDNMEQMGEWNPNVKQVKILQKIGQETMITHEISAETPGNVVGPRDFVNVRHAKRRGSTCFLAGMSTQHPGMPEQKGFVRAENGPTCIVMRPSADDPNKTKFTWLLSLDLKGWIPKTVINRVLSQTQVDFVNHLRDRMASGGGIDAAIAC", "length": 285 }, "evidence": [ { "id": "A0AAA9SJ06", "url": "https://omabrowser.org/oma/group/A0AAA9SJ06/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06" } ], "pmid": "" }, { "name": "cholesterol transfer activity", "id": "GO:0120020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39747", "name": "", "equation": "cholesterol(in) = cholesterol(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "39747", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39747" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ06" }, { "id": "PS50848", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "START", "eco_id": "ECO_0000259", "start_pos": 67, "end_pos": 280, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ08-1", "uniprot_ac": "A0AAA9SJ08", "uniprot_id": "A0AAA9SJ08_BOVIN", "mass": { "chemical_mass": 50727.0, "monoisotopic_mass": 50727.0 }, "refseq": {}, "gene_names": [ { "name": "PSMD12", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 12", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome regulatory subunit RPN5", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08#function" }, { "database": "UniProtKB", "id": "ARBA00002362", "url": "https://www.uniprot.org/uniprotkb/ARBA00002362#function" }, { "database": "UniProtKB", "id": "A0AAF6YJJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJJ1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08", "locus": { "chromosome": "19", "start_pos": 49515377, "end_pos": 49331839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002423", "url": "https://www.ensembl.org/id/ENSBTAG00000002423" } ] } } ], "crossref": [ { "id": "A0AAA9SJ08", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ08", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10855", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10855", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10855:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10855:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 436, "header": "tr|A0AAA9SJ08-1|A0AAA9SJ08_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus OX=9913 GN=PSMD12 PE=3 SV=1 CANONICAL=A0AAA9SJ08-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08/entry#A0AAA9SJ08-1", "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ", "length": 436, "header": "tr|A0AAA9SJ08-1|A0AAA9SJ08_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus OX=9913 GN=PSMD12 PE=3 SV=1 CANONICAL=A0AAA9SJ08-1" }, "locus": { "chromosome": "19", "start_pos": 49515006, "end_pos": 49495053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120355.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120355.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086229.1" } ] } }, { "isoform_ac": "A0AAF6YJJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08/entry#A0AAF6YJJ1-1", "sequence": { "sequence": "MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAIVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGYTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLQ", "length": 425, "header": "tr|A0AAF6YJJ1-1|A0AAF6YJJ1_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus OX=9913 GN=PSMD12 PE=3 SV=2 CANONICAL=A0AAA9SJ08-1" }, "locus": { "chromosome": "19", "start_pos": 49515006, "end_pos": 49495053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003145.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003145.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003145.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003145.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08" } ], "pmid": "" }, { "name": "proteasome complex", "id": "GO:0000502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000502", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ08" }, { "id": "PS50250", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50250" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000259", "start_pos": 222, "end_pos": 400, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 379, "end_pos": 381 }, { "start_pos": 420, "end_pos": 422 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ10-1", "uniprot_ac": "A0AAA9SJ10", "uniprot_id": "A0AAA9SJ10_BOVIN", "mass": { "chemical_mass": 31152.0, "monoisotopic_mass": 31152.0 }, "refseq": { "ac": "XP_005221619", "name": "coiled-coil domain-containing protein 152", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221619" }, "gene_names": [ { "name": "CCDC152", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10" } ] }, { "name": "CCDC152", "type": "synonym", "evidence": [ { "id": "XP_005221619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221619" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 152", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 152", "type": "synonym", "evidence": [ { "id": "XP_005221619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221619" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC152", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10", "locus": { "chromosome": "20", "start_pos": 31770817, "end_pos": 31811825, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033221", "url": "https://www.ensembl.org/id/ENSBTAG00000033221" } ] } } ], "crossref": [ { "id": "A0AAA9SJ10", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033221", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033221", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767877", "url": "https://www.ncbi.nlm.nih.gov/gene/767877", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767877", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767877", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTKLNCV", "url": "https://omabrowser.org/oma/group/MTKLNCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJA8", "url": "https://www.orthodb.org/?gene=F1MJA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35253:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35253:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005221619", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221619", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJA8", "url": "https://www.uniprot.org/uniprotkb/F1MJA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJA8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQNSEGCMKKISSVNLDKLINDFSQIEKKMIESSGKNNILDMQLEKANCLLRVMQTKEVAMKQECATLHDMIKGLQHTIEYQHNLKGENEQLKRNADLMKEKFKMHEQEHRNNIAKLMSEMKIKEEGHKIEKTKLYQDMQKKVKLSEEKNKELIEKKELEISELNAKLRTQEREKQNEMIKLQLEFDAKLARVQTKTKSYPDSTVSPHSIYKRKLQHLQEEKDKEIAVLRNTVRDLEQRLSVSKDSQVKLVGKDPRFKRRRF", "length": 263, "header": "tr|A0AAA9SJ10-1|A0AAA9SJ10_BOVIN Isoform 1 of Coiled-coil domain containing 152 OS=Bos taurus OX=9913 GN=CCDC152 PE=4 SV=1 CANONICAL=A0AAA9SJ10-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10/entry#A0AAA9SJ10-1", "sequence": { "sequence": "MNQNSEGCMKKISSVNLDKLINDFSQIEKKMIESSGKNNILDMQLEKANCLLRVMQTKEVAMKQECATLHDMIKGLQHTIEYQHNLKGENEQLKRNADLMKEKFKMHEQEHRNNIAKLMSEMKIKEEGHKIEKTKLYQDMQKKVKLSEEKNKELIEKKELEISELNAKLRTQEREKQNEMIKLQLEFDAKLARVQTKTKSYPDSTVSPHSIYKRKLQHLQEEKDKEIAVLRNTVRDLEQRLSVSKDSQVKLVGKDPRFKRRRF", "length": 263, "header": "tr|A0AAA9SJ10-1|A0AAA9SJ10_BOVIN Isoform 1 of Coiled-coil domain containing 152 OS=Bos taurus OX=9913 GN=CCDC152 PE=4 SV=1 CANONICAL=A0AAA9SJ10-1" }, "locus": { "chromosome": "20", "start_pos": 31807156, "end_pos": 31771547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111316.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111316.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083786.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083786.1" } ] } }, { "isoform_ac": "F1MJA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ10/entry#F1MJA8-1", "sequence": { "sequence": "MNQNSEGCMKKISSVNLDKLINDFSQIEKKMIESSGKNNILDMQLEKANCLLRVMQTKEVAMKQGENEQLKRNADLMKEKFKMHEQEHRNNIAKLMSEMKIKEEGHKIEKTKLYQDMQKKVKLSEEKNKELIEKKELEISELNAKLRTQEREKQNEMIKLQLEFDAKLARVQTKTKSYPDSTVSPHSIYKRKLQHLQEEKDKEIAVLRNTVRDLEQRLSVSKDSQVKLVGKDPRFKRRRF", "length": 240, "header": "tr|F1MJA8-1|A0AAA9SJ10_BOVIN Computationally mapped isoform of Coiled-coil domain containing 152 OS=Bos taurus OX=9913 GN=CCDC152 PE=4 SV=2 CANONICAL=A0AAA9SJ10-1" }, "locus": { "chromosome": "20", "start_pos": 31807156, "end_pos": 31771547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047200.2", "url": "https://www.ensembl.org/id/ENSBTAT00000047200.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044423.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767877", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767877", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SWJ8-1", "protein_name": "Coiled-coil domain containing 152", "gene_name": "CCDC152", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNQSSEGCMKKIGSVNLDKLINDFSQIEKKMIEISGKNNILDMQLEKANCLLKVMQTKEVSIKEGENEQLKRNSDLMKEKLKSHEQEYKNNIAKLMNEMKIKEEGHKIEITKLYQDMQKKVELNEEKNKELIEKKEMEISELNAKLRTQEKEKQNEIVKLQLEFDAKLARVQTKAKPYPDSTVLPHSIYRRKLQHLQEEKNKEIAILRNTIHDLEQRLSVSKDSQLKLVGKDSHFKRRRF", "length": 240 }, "evidence": [ { "id": "A0AAA9SJ10", "url": "https://omabrowser.org/oma/group/A0AAA9SJ10/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2N3H7-1", "protein_name": "Coiled-coil domain-containing protein 152 isoform X1", "gene_name": "Ccdc152", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDQSNEGSMKKISNVNLDKLIDDFSQIEKKMIEITGKNNLLDIQLEKNNSLLKIMQTKEATIKEECTTLHTMIKGLQQTIQYQHNLKDENEQLKRNVEFMKEKLKSHEQEYKNSIAKLISEMKIKEEGHKIEMSKLFQDMQKKVELKEEKHQELMAKKEMEISELNTKFRTQEKEKQNEILRLRLEFDTKLARVQTKSKSYPDATILPQSIYRRKLQYLQEEKSKEIASLQNTIRDLEQRLAAVKDSRLTRRRF", "length": 254 }, "evidence": [ { "id": "A0AAA9SJ10", "url": "https://omabrowser.org/oma/group/A0AAA9SJ10/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E9PX14-1", "protein_name": "Coiled-coil domain containing 152", "gene_name": "Ccdc152", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQNSEECTKKIRTVNLDKLIDDFSQIEKKMIETAGKNNLLDIQLEKTNSLLKIMQTKETSMKEECIILHTMIKGLQQTVQYQHNLKDENEQLKRNVDFMKEKLKSHEQEYKNKIAKLISEMKIKEEEHKTEMSKLYLDMQKKVELNEEKHKELMARKEMEISELNAKLRTQEKEKQNEILRLHLEFDTKLARAQTKSKSYPDTTILLQSIYRRKLQHLQEEKSKEIASLQNTIRDLEQRLAACKDTRLMRRRF", "length": 254 }, "evidence": [ { "id": "A0AAA9SJ10", "url": "https://omabrowser.org/oma/group/A0AAA9SJ10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M7D1-1", "protein_name": "Coiled-coil domain containing 152", "gene_name": "Ccdc152", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDQNSEGSMKKTSTVNLDKLIDDFSQIEKKMIEVTGKNNLLDIRLEKTNSLLKIMQAKETSMKEECITLHTMIKGLQQTVQYQHNLKGENEQLKRNVDFMKEKLKSHEQEYKNNIAKLISEMKIKEEEHKIELSKLYQDMQKKVELNEEKHKELMAKKEMEISELNATLKTQEKEKRNEILRLHIEFDTKLARAQTKSKPYPEATILPQSIYRRKLQHLQEEKNKEIASLQNTIRDLEQRLAASKDTRLTRRRF", "length": 254 }, "evidence": [ { "id": "A0AAA9SJ10", "url": "https://omabrowser.org/oma/group/A0AAA9SJ10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4G0S7-1", "protein_name": "Coiled-coil domain-containing protein 152", "gene_name": "CCDC152", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDQSSEGCMKKISSVNLDKLINDFSQIEKKMVETNGKNNILDIQLEKSNCLLKVMQAKEVSIKEECATLHNIIKGLQQTIEYQQNLKGENEQLKISADLIKEKLKSHEQEYKNNIAKLVSEMKIKEEGYKKEISKLYQDMQRKVELNEEKHKELIEKKEMEISELNAKLRSQEKEKQNEIIKLQLEFDAKLARVQTKSKSYQDSTVLPQSIYRRKLQHFQEEKNKEIAILRNTIRDLEQRLSVGKDSHLKRRRF", "length": 254 }, "evidence": [ { "id": "A0AAA9SJ10", "url": "https://omabrowser.org/oma/group/A0AAA9SJ10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ22-1", "uniprot_ac": "A0AAA9SJ22", "uniprot_id": "A0AAA9SJ22_BOVIN", "mass": { "chemical_mass": 57270.0, "monoisotopic_mass": 57270.0 }, "refseq": {}, "gene_names": [ { "name": "SLC29A3", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ] } ], "protein_names": [ { "name": "Solute carrier family 29 member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC29A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22", "locus": { "chromosome": "28", "start_pos": 27499257, "end_pos": 27454135, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046357", "url": "https://www.ensembl.org/id/ENSBTAG00000046357" } ] } } ], "crossref": [ { "id": "A0AAA9SJ22", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046357", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046357", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GSPWTTK", "url": "https://omabrowser.org/oma/group/GSPWTTK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10332", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10332:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10332:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01733", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01733", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-83936", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-83936", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9755088", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755088", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX44", "url": "https://www.uniprot.org/uniprotkb/G3MX44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX44-1", "url": "https://www.uniprot.org/uniprotkb/G3MX44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGACPQPAARERRPVCKPGSAGGGGAGGGAWRRSPASGPAEPGVAVAAAAGEAAAVAASDGDMAIISEDDFRHTSNSTYRTASSSLRADQEALLEKLLDRPPPSLQRPEDRFNGTYIIFFSLGIGGLLPWNFFVTAQEYWIFKLSNCSSPAAGEEPKDSDILNYFESYLAVASTVPSVLCLALNFLLVNRVPIRVRVLASLTVMLAIFIVMTVLVKVDTSSWTHSFFTITITCMAILSGTSTIFNSSVFGMTGSFPMRNSQALISGGAMGGTLSAVASLVDLAVASDVTDSTLAFFLTADIFLALCIGLYLLLPRLDYARYYMKPVWPTVFSGEEQLPQDSPSPTSVAPGSSDPQTPPLGPILKKTTGLGFCIIYLFFITSLIFPAICTNIESLSKGSGSPWSTKFFVPLTTFLLYNFADLCGRQVTAWIQVPGPRSKALPGLALLRTCFVPLFVFCNYQPRGHLHTVLFQSDVYPVLFTSLLGLSNGYLSTLALIYGPKIVPRELAEATGVVMTFYMGLGLVLGSACSALLVHLI", "length": 536, "header": "tr|A0AAA9SJ22-1|A0AAA9SJ22_BOVIN Isoform 1 of Solute carrier family 29 member 3 OS=Bos taurus OX=9913 GN=SLC29A3 PE=3 SV=1 CANONICAL=A0AAA9SJ22-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22/entry#A0AAA9SJ22-1", "sequence": { "sequence": "MGACPQPAARERRPVCKPGSAGGGGAGGGAWRRSPASGPAEPGVAVAAAAGEAAAVAASDGDMAIISEDDFRHTSNSTYRTASSSLRADQEALLEKLLDRPPPSLQRPEDRFNGTYIIFFSLGIGGLLPWNFFVTAQEYWIFKLSNCSSPAAGEEPKDSDILNYFESYLAVASTVPSVLCLALNFLLVNRVPIRVRVLASLTVMLAIFIVMTVLVKVDTSSWTHSFFTITITCMAILSGTSTIFNSSVFGMTGSFPMRNSQALISGGAMGGTLSAVASLVDLAVASDVTDSTLAFFLTADIFLALCIGLYLLLPRLDYARYYMKPVWPTVFSGEEQLPQDSPSPTSVAPGSSDPQTPPLGPILKKTTGLGFCIIYLFFITSLIFPAICTNIESLSKGSGSPWSTKFFVPLTTFLLYNFADLCGRQVTAWIQVPGPRSKALPGLALLRTCFVPLFVFCNYQPRGHLHTVLFQSDVYPVLFTSLLGLSNGYLSTLALIYGPKIVPRELAEATGVVMTFYMGLGLVLGSACSALLVHLI", "length": 536, "header": "tr|A0AAA9SJ22-1|A0AAA9SJ22_BOVIN Isoform 1 of Solute carrier family 29 member 3 OS=Bos taurus OX=9913 GN=SLC29A3 PE=3 SV=1 CANONICAL=A0AAA9SJ22-1" }, "locus": { "chromosome": "28", "start_pos": 27498485, "end_pos": 27454185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131530.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131530.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086246.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086246.1" } ] } }, { "isoform_ac": "G3MX44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22/entry#G3MX44-1", "sequence": { "sequence": "MAIISEDDFRHTSNSTYRTASSSLRADQEALLEKLLDRPPPSLQRPEDRFNGTYIIFFSLGIGGLLPWNFFVTAQEYWIFKLSNCSSPAAGEEPKDSDILNYFESYLAVASTVPSVLCLALNFLLVNRVPIRVRVLASLTVMLAIFIVMTVLVKVDTSSWTHSFFTITITCMAILSGTSTIFNSSVFGMTGSFPMRNSQALISDEQTLVPRSHVSPQVTARGAMGGTLSAVASLVDLAVASDVTDSTLAFFLTADIFLALCIGLYLLLPRLDYARYYMKPVWPTVFSGEEQLPQDSPSPTSVAPGSSDPQTPPLGPILKKTTGLGFCIIYLFFITSLIFPAICTNIESLSKGSGSPWSTKFFVPLTTFLLYNFADLCGRQVTAWIQVPGPRSKALPGLALLRTCFVPLFVFCNYQPRGHLHTVLFQSDVYPVLFTSLLGLSNGYLSTLALIYGPKIVPRELAEATGVVMTFYMGLGLVLGSACSALLVHLI", "length": 491, "header": "tr|G3MX44-1|G3MX44_BOVIN Computationally mapped isoform of Solute carrier family 29 member 3 OS=Bos taurus OX=9913 GN=SLC29A3 PE=3 SV=3 CANONICAL=A0AAA9SJ22-1" }, "locus": { "chromosome": "28", "start_pos": 27498485, "end_pos": 27454371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065071.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065071.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054103.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054103.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-83936", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-83936", "resource": "Reactome", "description": "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" }, { "id": "R-BTA-9755088", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755088", "resource": "Reactome", "description": "Ribavirin ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZCK9-1", "protein_name": "Solute carrier family 29 member 3", "gene_name": "SLC29A3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIFLFPCRASILGVRAQLSLFPRLVMCQHPNIHSMRLSMRVVTSVGAEQPGSSLVVELNQKESYQPLSARLESTLATAKTLPKDYFESYISIASTVPSVLCLLGNFLLVNRVPASVRILSSLFIMLSIFLVITVLVKVDTSSWTTCFFALTIGCVVVVSGASTIFTSSILGLSSRFPMRNSQALLAGQAMGGTVSAIASIIDLAAAADVTDSALAYFLTADIFLVVCIMVYLLLPRLEYSRYYMGSHWEHPSLATTSPSSPLEDQTEPGGSAHSLPQSTAVPPLRPILRKTAALGFCLFYVFFVSIIIFPSLSSSIQSVHQNSGSLWATKYFVPLTSFLLYNFADWCGRQITAWIQAPGPNSRLLPVLVLLRTIFLPLFILCNYQPRAHIRTVLFDHDIYPVAFTTLLGLSNGYLGTLTLVYGPKIMPKELAEAAGVVMSFYLVLGLALGSACSVLVVHLI", "length": 461 }, "evidence": [ { "id": "A0AAA9SJ22", "url": "https://omabrowser.org/oma/group/A0AAA9SJ22/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P31381-1", "protein_name": "Nucleoside transporter FUN26", "gene_name": "FUN26", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTSADTDTIKKPILAVPEPALADTHSEEISRSGEEHESENNEHSDEEGDNYSEREQSVSTEPLDTLPLRKKLKNLSYITFFAIGIGLLWPWNCILSASQYFKHDIFKDTSIWAKIFTSSMMSFSTISSMLFNIYLAKRQYKYSRRVINGLVWEIIVFTVMCFFTILHFLLPKWFNFMFIMMLVVISSMGTAMTQNGIMAIANVFGSEYSQGVMVGQAVAGVLPSLVLFALAFIENSSVSTTGGILLYFFTTTLVVTICVVMFSVSKISRKVNENWNVEDGHITDVLLGSLRSNEEEIRIVGRIDQMEDEDHRRTNGTRDDNDEGEELQLKVPFEVLFAKLKYLVLSIFTTFVVTLVFPVFASATYVTGLPLSNAQYIPLIFTLWNLGDLYGRVIADWPMFRDQKFTPRKTFIYSLLRVAAIPLFLMFTAITSSSSGDEEHNGSVIVDLCYMLLQFLFGVTNGHVISMSFMKVPEQLDNDDEKEAAGGFTNIFVSTGLALGSIISYVFVFIIDFIIR", "length": 517 }, "evidence": [ { "id": "A0AAA9SJ22", "url": "https://omabrowser.org/oma/group/A0AAA9SJ22/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q80WK7-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "Slc29a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFASEDIAYHSSNAVYRVPSNRHEADQEALLGKPLDYPAPGLQRPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAFKLRNCSSPASGKDPEDADILNYFESYLAVASTVPSLLFLVANFLLVNRIRVHVRVLASLSVSLAIFVVMAVLVRVDTSSWTRGFFSIAMACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGGTVSAVASLVDLAASSDVRDSALAFFLTAAVFLGLCVGLYLLLPQLEYARYYMRPVVPIHVFSSEDSPPRDAPSTSSVAPASRAVHTPPLGPILKKTAGLGFCAVFLYFITALIFPAISTNIQPMHKGTGSPWTSKFYVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKLLPILAVSRVCLVPLFLLCNYQPRSHLTLVLFQSDIYPILFTCLLGLSNGYLSTLVLMYGPKIVPRELAEATSVVMLFYMSLGLMLGSACAALLEHFI", "length": 475 }, "evidence": [ { "id": "A0AAA9SJ22", "url": "https://omabrowser.org/oma/group/A0AAA9SJ22/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VXY7-1", "protein_name": "Equilibrative nucleotide transporter 1", "gene_name": "ENT1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTPISQRISQKSPKLRETKQIQMTTTDKSAGIVTDSEAGPETSLLLNPHEGSTKKAPSDSYHFAYIIYFTLGVGFLLPWNAFITAVDYFSYLYPSTAVDRIFAVIYMLVALVCLFVIVVFYAHKSLASFRINLGLLLFVIALLVVPVLDLVYVKGQVGLYAGFDVTSAAVALSGLGDALMQGGLIGVAGEMPERYMQAVVAGTAGSGVLVSLLRILTKAVYPQDPDGLRKSANLYFAVGIVVMVICAVFYNVAHKLPVIKFHEERKNEELIREKSEEKGSLTGLAWRTTLWDIVTKVKSHGFGIVLLYMVTLSIFPGYITEDVHSELLTDWYPILLIAAYNVFDLVGKCLTAVFMLEDEKIAVGGSIARLLFYPLFWGCLHGPMFLRTEIPVTILTCLLGLTNGYLTSVLMILAPKSVPLRHSETAGIVTVMFLVVGLASGSVIAWFWVI", "length": 450 }, "evidence": [ { "id": "A0AAA9SJ22", "url": "https://omabrowser.org/oma/group/A0AAA9SJ22/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q99P65-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "Slc29a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFASEDNVYHSSNAVYRAPSNHQEADQEALLGKLLDYPAPGLQRPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAYKLRNCSSPASGEDPEDMDILNYFESYLAVASTVPSLLFLVANFLLVNRVQVHVRVLASLSVSLAIFVVMIVLVKVDTSSWTRGFFSLTIACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGGTVSAVALLVDLAASSDVRDSTLAFFLMAAVFLGLCMGLYLLLSQLEYARYYMRPVAPVRVFSGEDNPSQDAPSASSVAPASRVMHTPPLGPILKKTASLGFCAVSLYFVTAFIIPAISTNIQSMHKGTGSPWTSKFFVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKLLPGLVVSRFCLVPLFLLCNYQPRSHLTKVLFQSDIYPVLFTCLLGLSNGYLSTLVLIYGPKIVPRELAEATSVVMLFYMSVGLMLGSACAALLEHFI", "length": 475 }, "evidence": [ { "id": "A0AAA9SJ22", "url": "https://omabrowser.org/oma/group/A0AAA9SJ22/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSLGIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLVANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGASTVFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVFLVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRPILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADLCGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI", "length": 475 }, "evidence": [ { "id": "A0AAA9SJ22", "url": "https://omabrowser.org/oma/group/A0AAA9SJ22/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "neurotransmitter transmembrane transporter activity", "id": "GO:0005326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005326", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "cytidine transmembrane transporter activity", "id": "GO:0015212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "uridine transmembrane transporter activity", "id": "GO:0015213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015213", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "monoamine transmembrane transporter activity", "id": "GO:0008504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008504", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "guanine transmembrane transporter activity", "id": "GO:0015208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015208", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "uracil transmembrane transporter activity", "id": "GO:0015210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015210", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "nucleoside transmembrane transporter activity", "id": "GO:0005337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005337", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "dopamine transport", "id": "GO:0015872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "norepinephrine transport", "id": "GO:0015874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "serotonin transport", "id": "GO:0006837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "adenosine transport", "id": "GO:0032238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032238", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" }, { "name": "inosine transport", "id": "GO:0035340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035340", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 245, "end_pos": 247 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ28-1", "uniprot_ac": "A0AAA9SJ28", "uniprot_id": "A0AAA9SJ28_BOVIN", "mass": { "chemical_mass": 45007.0, "monoisotopic_mass": 45007.0 }, "refseq": {}, "gene_names": [ { "name": "MCUB", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ] } ], "protein_names": [ { "name": "Calcium uniporter regulatory subunit MCUb", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCUB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28", "locus": { "chromosome": "6", "start_pos": 15621358, "end_pos": 15822199, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012995", "url": "https://www.ensembl.org/id/ENSBTAG00000012995" } ] } } ], "crossref": [ { "id": "A0AAA9SJ28", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012995", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012995", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504728", "url": "https://www.ncbi.nlm.nih.gov/gene/504728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPW1", "url": "https://www.orthodb.org/?gene=A0A3Q1LPW1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13462:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13462:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04678", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04678", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LPW1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPW1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QZT1", "url": "https://www.uniprot.org/uniprotkb/F6QZT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QZT1-1", "url": "https://www.uniprot.org/uniprotkb/F6QZT1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMLRRGPWPWRARLLPTPGTQGHAHPRPPMPQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKASLTSLLLLLLLNRFSPTLCDPMDSSPPGSSVHGILQARTLQWAAMSFIATSLNYHAPPVLRFVCFYLVLIRSLNTSKYRKG", "length": 392, "header": "tr|A0AAA9SJ28-1|A0AAA9SJ28_BOVIN Isoform 1 of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#A0A3Q1LPW1-1", "sequence": { "sequence": "MVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKATEALRHVRRSLYLRMQVEELDERK", "length": 304, "header": "tr|A0A3Q1LPW1-1|A0A3Q1LPW1_BOVIN Computationally mapped isoform of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15801033, "end_pos": 15717984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082042.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082042.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059050.1" } ] } }, { "isoform_ac": "A0AAA9SJ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#A0AAA9SJ28-1", "sequence": { "sequence": "MMLRRGPWPWRARLLPTPGTQGHAHPRPPMPQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKASLTSLLLLLLLNRFSPTLCDPMDSSPPGSSVHGILQARTLQWAAMSFIATSLNYHAPPVLRFVCFYLVLIRSLNTSKYRKG", "length": 392, "header": "tr|A0AAA9SJ28-1|A0AAA9SJ28_BOVIN Isoform 1 of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15813056, "end_pos": 15678478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135453.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135453.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083807.1" } ] } }, { "isoform_ac": "A0AAA9SNG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#A0AAA9SNG0-1", "sequence": { "sequence": "MFMVFTAVFAFQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKATEALRHVRRSLYLRMQVEELDERK", "length": 315, "header": "tr|A0AAA9SNG0-1|A0AAA9SNG0_BOVIN Computationally mapped isoform of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15822000, "end_pos": 15717984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116306.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116306.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085430.1" } ] } }, { "isoform_ac": "A0AAA9SSX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#A0AAA9SSX6-1", "sequence": { "sequence": "MMLRRGPWPWRARLLPTPGTQGHAHPRPPMPQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKVFYDALI", "length": 317, "header": "tr|A0AAA9SSX6-1|A0AAA9SSX6_BOVIN Computationally mapped isoform of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15813056, "end_pos": 15717807, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087092.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087092.1" } ] } }, { "isoform_ac": "A0AAA9TH94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#A0AAA9TH94-1", "sequence": { "sequence": "MMLRRGPWPWRARLLPTPGTQGHAHPRPPMPQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKLQEEDDQASNEESLQLSPP", "length": 329, "header": "tr|A0AAA9TH94-1|A0AAA9TH94_BOVIN Computationally mapped isoform of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15813056, "end_pos": 15621515, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098136.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098136.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096435.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096435.1" } ] } }, { "isoform_ac": "A0AAA9TPE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#A0AAA9TPE4-1", "sequence": { "sequence": "MMLRRGPWPWRARLLPTPGTQGHAHPRPPMPQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKANFQEGCTVSLYCIMRRADSLEK", "length": 333, "header": "tr|A0AAA9TPE4-1|A0AAA9TPE4_BOVIN Computationally mapped isoform of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15813056, "end_pos": 15696281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116747.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116747.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100265.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100265.1" } ] } }, { "isoform_ac": "F6QZT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28/entry#F6QZT1-1", "sequence": { "sequence": "MWAQQVLCVKLCGNLKFYQSNLYSTLVPSDEITVSYKHGLPLITLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIRTAAIFTADGTEIAASTLMEILLKNDFKLVIDKITYDVQCPMKENLSSEQATEMENMKSLVYRLFTALHLEEFQKKREHHLLEKIDHLKGQLQPLEQMKARIEARSEAKISGLLWAGLAMLSVQGGAMAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLHFFHKRSKQQHFDVEQYNKLKDDLAKATEALRHVRRSLYLRMQVEELDERK", "length": 308, "header": "tr|F6QZT1-1|F6QZT1_BOVIN Computationally mapped isoform of Calcium uniporter regulatory subunit MCUb OS=Bos taurus OX=9913 GN=MCUB PE=3 SV=1 CANONICAL=A0AAA9SJ28-1" }, "locus": { "chromosome": "6", "start_pos": 15748043, "end_pos": 15717984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017276.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017276.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017276.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017276.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 17, "start_aa": "Thr", "end_pos": 17, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr17", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "pmid": "" }, { "name": "mitochondrial calcium ion homeostasis", "id": "GO:0051560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051560", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "pmid": "" }, { "name": "negative regulation of calcium import into the mitochondrion", "id": "GO:0110099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110099", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium channel inhibitor activity", "id": "GO:0019855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019855", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "uniplex complex", "id": "GO:1990246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ28" }, { "id": "PF04678", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04678" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calcium uniporter protein C-terminal", "eco_id": "ECO_0000259", "start_pos": 102, "end_pos": 304, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 17 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 385, "end_pos": 387 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ53-1", "uniprot_ac": "A0AAA9SJ53", "uniprot_id": "A0AAA9SJ53_BOVIN", "mass": { "chemical_mass": 123236.0, "monoisotopic_mass": 123236.0 }, "refseq": {}, "gene_names": [ { "name": "RADIL", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" } ] } ], "protein_names": [ { "name": "Ras-associating and dilute domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53#function" }, { "database": "UniProtKB", "id": "ARBA00057550", "url": "https://www.uniprot.org/uniprotkb/ARBA00057550#function" }, { "database": "UniProtKB", "id": "A0AAA9SUM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RADIL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53", "locus": { "chromosome": "25", "start_pos": 39189390, "end_pos": 39137001, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030690", "url": "https://www.ensembl.org/id/ENSBTAG00000030690" } ] } } ], "crossref": [ { "id": "A0AAA9SJ53", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ53", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06690", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06690", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15472", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15472", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506708", "url": "https://www.ncbi.nlm.nih.gov/gene/506708", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16027:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16027:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01843", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01843", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPLVQNSFLLLRCICSAQLLSRVQLFLTPWTVARQAPLSVGFSRTRPLPCRWPESRVLVGEDGPTMFYGTHFIMSPPAKSKLKRQGQLLSSVLSRTLSYKYRDLDTPYSGLGASDDPAELSTQLSAPGVLKVFGDSVCSGTHYKSVLATGTSSARELVREALERYALSPERAAQFVLCDVVGQASGGGHAWQAQGFRVFGDNEKPLLIQELWKPREGLSRRFELRKRSEVEELAAKDVDTMTAGINAQARRLQRSRAKGTPVPAAGGTRSPPPPRLRRTVSETSLSSASTRDPEEPGRDTMRCSLYESPHLLLLQGYSQQHDSLVYVLNRERHTVGQRTPSSKPSISLSAPDILPLHCTLRRRQPSGQGPAGAQLVLEPLPGAPVAVNFAEVGARPVVLRHGDLLSLGLYYLLLFKDPAQAQPLPAQALARLRTAPQSCRLCGALLRARGAPAPARPALPRPRPLQLEFEPDVEDTLLQRIMTLIEPDGDDHKLTPAFLLCLCIQHSATRLEPGSFGQLLLKIARLIRETVWEKTKELAEKQAHLPEPPSAASFSLAGLAPDLQHILFWMSNSVELLYFVQQRCPLYMQSLEEELDVTGSKESLFSCALTASEEAMAVLEEVVLYAFQQCVYYVSKALYVCLPALLECPPFQSERRESWSAGPPLPEELRRVVAVYQAALDLLRRLHVHPEVAAQVLAYLFFFSGTLLLNQLLDKGPSLSCFHWPRGVQACARLQQLLEWIRSAGFGEAGERFFRKLSCTLNLLATPSAQLIQMSWASLRAAFPALSPAQLHRLLTQYQLASAMGPMSAWEPGAQDGPAAFKSEEVLESYENPPPIVLPSEGFQVDLDTECPDDRVYQHLLYIRHFLCGLRSQPGPSGAPTRPEGLQGLHHASPEGHPEAQSCPLASRDPTGGAQETGLEHPLSSVGGPWAQGVPGRPPGCPSHGGLQAVDPHGDPSCLLTPPGTPLGLDPASPDWPEGSSACRRALPEGRRTGPGGPRGASREGDCAAPEDEPPPAPSSHSSSTDDFCYMFVVELERGPSGLGMGLIDGMHTPLGAPGLYIQTLLPGSPAAADGRLALGDRILEVNGSSLAGVSYPRAVDLIRHGGKKMRFLVAKSDVETARKVRFRTPPP", "length": 1133, "header": "tr|A0AAA9SJ53-1|A0AAA9SJ53_BOVIN Isoform 1 of Ras-associating and dilute domain-containing protein OS=Bos taurus OX=9913 GN=RADIL PE=3 SV=1 CANONICAL=A0AAA9SJ53-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53/entry#A0AAA9SJ53-1", "sequence": { "sequence": "MHPLVQNSFLLLRCICSAQLLSRVQLFLTPWTVARQAPLSVGFSRTRPLPCRWPESRVLVGEDGPTMFYGTHFIMSPPAKSKLKRQGQLLSSVLSRTLSYKYRDLDTPYSGLGASDDPAELSTQLSAPGVLKVFGDSVCSGTHYKSVLATGTSSARELVREALERYALSPERAAQFVLCDVVGQASGGGHAWQAQGFRVFGDNEKPLLIQELWKPREGLSRRFELRKRSEVEELAAKDVDTMTAGINAQARRLQRSRAKGTPVPAAGGTRSPPPPRLRRTVSETSLSSASTRDPEEPGRDTMRCSLYESPHLLLLQGYSQQHDSLVYVLNRERHTVGQRTPSSKPSISLSAPDILPLHCTLRRRQPSGQGPAGAQLVLEPLPGAPVAVNFAEVGARPVVLRHGDLLSLGLYYLLLFKDPAQAQPLPAQALARLRTAPQSCRLCGALLRARGAPAPARPALPRPRPLQLEFEPDVEDTLLQRIMTLIEPDGDDHKLTPAFLLCLCIQHSATRLEPGSFGQLLLKIARLIRETVWEKTKELAEKQAHLPEPPSAASFSLAGLAPDLQHILFWMSNSVELLYFVQQRCPLYMQSLEEELDVTGSKESLFSCALTASEEAMAVLEEVVLYAFQQCVYYVSKALYVCLPALLECPPFQSERRESWSAGPPLPEELRRVVAVYQAALDLLRRLHVHPEVAAQVLAYLFFFSGTLLLNQLLDKGPSLSCFHWPRGVQACARLQQLLEWIRSAGFGEAGERFFRKLSCTLNLLATPSAQLIQMSWASLRAAFPALSPAQLHRLLTQYQLASAMGPMSAWEPGAQDGPAAFKSEEVLESYENPPPIVLPSEGFQVDLDTECPDDRVYQHLLYIRHFLCGLRSQPGPSGAPTRPEGLQGLHHASPEGHPEAQSCPLASRDPTGGAQETGLEHPLSSVGGPWAQGVPGRPPGCPSHGGLQAVDPHGDPSCLLTPPGTPLGLDPASPDWPEGSSACRRALPEGRRTGPGGPRGASREGDCAAPEDEPPPAPSSHSSSTDDFCYMFVVELERGPSGLGMGLIDGMHTPLGAPGLYIQTLLPGSPAAADGRLALGDRILEVNGSSLAGVSYPRAVDLIRHGGKKMRFLVAKSDVETARKVRFRTPPP", "length": 1133, "header": "tr|A0AAA9SJ53-1|A0AAA9SJ53_BOVIN Isoform 1 of Ras-associating and dilute domain-containing protein OS=Bos taurus OX=9913 GN=RADIL PE=3 SV=1 CANONICAL=A0AAA9SJ53-1" }, "locus": { "chromosome": "25", "start_pos": 39189166, "end_pos": 39137200, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112060.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112060.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085365.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085365.1" } ] } }, { "isoform_ac": "A0AAA9SUM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53/entry#A0AAA9SUM6-1", "sequence": { "sequence": "MFYGTHFIMSPPAKSKLKRQGQLLSSVLSRTLSYKYRDLDTPYSGLGASDDPAELSTQLSAPGVLKVFGDSVCSGTHYKSVLATGTSSARELVREALERYALSPERAAQFVLCDVVGQASGGGHAWQAQGFRVFGDNEKPLLIQELWKPREGLSRRFELRKRSEVEELAAKDVDTMTAGINAQARRLQRSRAKGTPVPAAGGTRSPPPPRLRRTVSETSLSSASTRDPEEPGRDTMRCSLYESPHLLLLQGYSQQHDSLVYVLNRERHTVGQRTPSSKPSISLSAPDILPLHCTLRRRQPSGQGPAGAQLVLEPLPGAPVAVNFAEVGARPVVLRHGDLLSLGLYYLLLFKDPAQAQPLPAQALARLRTAPQSCRLCGALLRARGAPAPARPALPRPRPLQLEFEPDVEDTLLQRIMTLIEPDGDDHKLTPAFLLCLCIQHSATRLEPGSFGQLLLKIARLIRETVWEKTKELAEKQAHLPEPPSAASFSLAGLAPDLQHILFWMSNSVELLYFVQQRCPLYMQSLEEELDVTGSKESLFSCALTASEEAMAVLEEVVLYAFQQCVYYVSKALYVCLPALLECPPFQSERRESWSAGPPLPEELRRVVAVYQAALDLLRRLHVHPEVAAQVLAYLFFFSGTLLLNQLLDKGPSLSCFHWPRGVQACARLQQLLEWIRSAGFGEAGERFFRKLSCTLNLLATPSAQLIQMSWASLRAAFPALSPAQLHRLLTQYQLASAMGPMSAWEPGAQDGPAAFKSEEVLESYENPPPIVLPSEGFQVDLDTECPDDRVYQHLLYIRHFLCGLRSQPGPSGAPTRPEGLQGLHHASPEGHPEAQSCPLASRDPTGGAQETGLEHPLSSVGGPWAQGVPGRPPGCPSHGGLQAVDPHGDPSCLLTPPGTPLGLDPASPDWPEGSSACRRALPEGRRTGPGGPRGASREGDCAAPEDEPPPAPSSHSSSTDDFCYMFVVELERGPSGLGMGLIDGMHTPLGAPGLYIQTLLPGSPAAADGRLALGDRILEVNGSSLAGVSYPRAVDLIRHGGKKMRFLVAKSDVETARKVRFRTPPP", "length": 1067, "header": "tr|A0AAA9SUM6-1|A0AAA9SUM6_BOVIN Computationally mapped isoform of Ras-associating and dilute domain-containing protein OS=Bos taurus OX=9913 GN=RADIL PE=3 SV=2 CANONICAL=A0AAA9SJ53-1" }, "locus": { "chromosome": "25", "start_pos": 39189166, "end_pos": 39139543, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132870.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132870.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087674.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087674.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 767, "start_aa": "Thr", "end_pos": 767, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr767", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1088, "end_pos": 1090, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" }, { "id": "PS51126", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51126" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dilute", "eco_id": "ECO_0000259", "start_pos": 522, "end_pos": 824, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 1034, "end_pos": 1119, "start_aa": "Val", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJ53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ53" }, { "id": "PS50200", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-associating", "eco_id": "ECO_0000259", "start_pos": 127, "end_pos": 230, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 767 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1088, "end_pos": 1090 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ59-1", "uniprot_ac": "A0AAA9SJ59", "uniprot_id": "A0AAA9SJ59_BOVIN", "mass": { "chemical_mass": 10536.0, "monoisotopic_mass": 10536.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ59/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ59", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJ59", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ59", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR057129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF23701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPSHLPRFSPEPWLAKTQSTSWRVKMSSTATAWPVEVLLRTCASRGLCWRQRTLPGDGDPWALVPQGKGCDTLPPPAPHDLRSSWAGESGALGFR", "length": 96, "header": "tr|A0AAA9SJ59-1|A0AAA9SJ59_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SJ59-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ59/entry#A0AAA9SJ59-1", "sequence": { "sequence": "MPPSHLPRFSPEPWLAKTQSTSWRVKMSSTATAWPVEVLLRTCASRGLCWRQRTLPGDGDPWALVPQGKGCDTLPPPAPHDLRSSWAGESGALGFR", "length": 96, "header": "tr|A0AAA9SJ59-1|A0AAA9SJ59_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SJ59-1" }, "locus": { "chromosome": "5", "start_pos": 29900515, "end_pos": 29899440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119302.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119302.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082609.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ72-1", "uniprot_ac": "A0AAA9SJ72", "uniprot_id": "A0AAA9SJ72_BOVIN", "mass": { "chemical_mass": 100348.0, "monoisotopic_mass": 100348.0 }, "refseq": {}, "gene_names": [ { "name": "OFCC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72" } ] } ], "protein_names": [ { "name": "Orofacial cleft 1 candidate gene 1 protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OFCC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJ72", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ72", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR031390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33862", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33862", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33862:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33862:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15680", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15680", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDREKFQQKALKQTKQKKSKSAEFLMVKGDGGAMEGTGNPAFNMSSPDLSAQQSSEKKVIRHDTRDRTLAAHQQKCRLQASAEPKGNEYSRNYFDPLMDEEINPRQCGMEVSQEDESIVAGTLSSEDPASSRKNLEHYKKDSEAISADSEEIERNTQKHVILPGSSSLEQDLTFDGEGLGEYIPMSCLKSDRTFEKTTSQGIIADPNVCEAGGVAKLGTLPEVIHPSKGVVWPWPCWKVEQSRSPQPLQVQMKCIRGLKNKVPQGCYLLKLSLLGQPGGCVLQWNPEEQLKTRTRPVRHGGNFYDVGLFFHESLYVVLPPKKDVKLGMAFLFELFILHGKYTYVHQVVGWATFPLYDSSMDVVEGKFKCPLLRGHYDQKVDSFRKTEDLICLDLDHWLCNLYFQVIKLPLHLNDQKNHKRHIQLPPEFPNCLMAEAESSVDNTEKKSCSSRSDGVKSFSHSSQGSISNKISPCPMDCDLSFSKEDHELHNKEKPTAWKTGETEDYSQDTSYLEELEKHKFSVCRSSATANAASGEFFKHLCFVLVSVSSELEFAQWQSQGFWYIILLMASLWFLRLYLHYLSQWFFLQAISTPVTKFRFSPLTVELCYPTSSLHIAEEMLVVVLGPFMLNTVVLSLVLVRWGCQLLFAFCPDVLSKLIITMGLWAVLDPLAVFTVDTVLGRLTQREETPVADAAKLYWMFERTMQSGILGVMLTVLLYVLLFIISSLILYVYCLRLHNDSWILDTFQRIHSEESKFFIPYDLEISNQELSYIIKRSEQWRGLNGERRKVAVYDYIWKKHGVQSSISSCDLQQHNEISMTALGPGGITSHVAVYTVYPSGFQELYRHFLRLPSGAIVEVTFGREAGNKLREIIRESQIDEEEI", "length": 882, "header": "tr|A0AAA9SJ72-1|A0AAA9SJ72_BOVIN Isoform 1 of Orofacial cleft 1 candidate gene 1 protein OS=Bos taurus OX=9913 GN=OFCC1 PE=4 SV=1 CANONICAL=A0AAA9SJ72-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72/entry#A0AAA9SJ72-1", "sequence": { "sequence": "MDREKFQQKALKQTKQKKSKSAEFLMVKGDGGAMEGTGNPAFNMSSPDLSAQQSSEKKVIRHDTRDRTLAAHQQKCRLQASAEPKGNEYSRNYFDPLMDEEINPRQCGMEVSQEDESIVAGTLSSEDPASSRKNLEHYKKDSEAISADSEEIERNTQKHVILPGSSSLEQDLTFDGEGLGEYIPMSCLKSDRTFEKTTSQGIIADPNVCEAGGVAKLGTLPEVIHPSKGVVWPWPCWKVEQSRSPQPLQVQMKCIRGLKNKVPQGCYLLKLSLLGQPGGCVLQWNPEEQLKTRTRPVRHGGNFYDVGLFFHESLYVVLPPKKDVKLGMAFLFELFILHGKYTYVHQVVGWATFPLYDSSMDVVEGKFKCPLLRGHYDQKVDSFRKTEDLICLDLDHWLCNLYFQVIKLPLHLNDQKNHKRHIQLPPEFPNCLMAEAESSVDNTEKKSCSSRSDGVKSFSHSSQGSISNKISPCPMDCDLSFSKEDHELHNKEKPTAWKTGETEDYSQDTSYLEELEKHKFSVCRSSATANAASGEFFKHLCFVLVSVSSELEFAQWQSQGFWYIILLMASLWFLRLYLHYLSQWFFLQAISTPVTKFRFSPLTVELCYPTSSLHIAEEMLVVVLGPFMLNTVVLSLVLVRWGCQLLFAFCPDVLSKLIITMGLWAVLDPLAVFTVDTVLGRLTQREETPVADAAKLYWMFERTMQSGILGVMLTVLLYVLLFIISSLILYVYCLRLHNDSWILDTFQRIHSEESKFFIPYDLEISNQELSYIIKRSEQWRGLNGERRKVAVYDYIWKKHGVQSSISSCDLQQHNEISMTALGPGGITSHVAVYTVYPSGFQELYRHFLRLPSGAIVEVTFGREAGNKLREIIRESQIDEEEI", "length": 882, "header": "tr|A0AAA9SJ72-1|A0AAA9SJ72_BOVIN Isoform 1 of Orofacial cleft 1 candidate gene 1 protein OS=Bos taurus OX=9913 GN=OFCC1 PE=4 SV=1 CANONICAL=A0AAA9SJ72-1" }, "locus": { "chromosome": "23", "start_pos": 46226255, "end_pos": 46000188, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082624.1" } ] } }, { "isoform_ac": "A0AAA9STX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ72/entry#A0AAA9STX8-1", "sequence": { "sequence": "ISLQKFQQKALKQTKQKKSKSAEFLMVKGDGGAMEGTGNPAFNMSSPDLSAQQSSEKKVIRHDTRDRTLAAHQQKCRLQASAEPKGNEYSRNYFDPLMDEEINPRQCGMEDLTFDGEGLGEYIPMSCLKSDRTFEKYVPLVVHLMCFIFLFVPFGVEQSRSPQPLQVQMKCIRGLKNKVPQGCYLLKLSLLGQPGGCVLQWNPEEQLKTRTRPVRHGGNFYDVGLFFHESLYVVLPPKKDVKLGMAFLFELFILHGKYTYVHQVVGWATFPLYDSSMDVVEGKFKCPLLRGHYDQKVDSFRKTEDLICLDLDHWLCNLYFQVIKLPLHLNDQKNHKRHIQLPPEFPNCLMAEAESSVDNTEKKSCSSRSDGVKSFSHSSQGSISNKISPCPMDCDLSFSKEDHELHNKEKPTAWKTGETEDYSQDTSYLEELEKHKFSVCRSSATANAASGEFFKHLCFVLVSVSSELEFAQWQSQGFWYIILLMASLWFLRLYLHYLSQWFFLQAISTPVTKFRFSPLTVELCYPTSSLHIAEEMLVVVLGPFMLNTVVLSLVLVRWGCQLLFAFCPDVLSKLIITMGLWAVLDPLAVFTVDTVLGRLTQREETPVADAAKLYWMFERTMQSGILGVMLTVLLYVLLFIISSLILYVYCLRLHNDSWILDTFQRIHSEESKFFIPYDLEISNQELSYIIKRSEQWRGLNGERRKVAVYDYIWKKHGVQSSISSCDLQQHNEISMTALGPGGITSHVAVYTVYPSGFQELYRHFLRLPSGAIVEVTFGREAGNKLREIIRESQIDEEEI", "length": 799, "header": "tr|A0AAA9STX8-1|A0AAA9STX8_BOVIN Computationally mapped isoform of Orofacial cleft 1 candidate gene 1 protein OS=Bos taurus OX=9913 GN=OFCC1 PE=4 SV=1 CANONICAL=A0AAA9SJ72-1" }, "locus": { "chromosome": "23", "start_pos": 46226255, "end_pos": 46005998, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097781.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097781.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086560.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086560.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 }, { "start_pos": 738, "end_pos": 740 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKU6-1", "uniprot_ac": "A0AAA9SKU6", "uniprot_id": "A0AAA9SKU6_BOVIN", "mass": { "chemical_mass": 31322.0, "monoisotopic_mass": 31322.0 }, "refseq": {}, "gene_names": [ { "name": "MEMO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6" } ] } ], "protein_names": [ { "name": "Protein MEMO1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#names_and_taxonomy" } ] }, { "name": "Mediator of ErbB2-driven cell motility 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEMO1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6", "locus": { "chromosome": "11", "start_pos": 14544697, "end_pos": 14656265, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007734", "url": "https://www.ensembl.org/id/ENSBTAG00000007734" } ] } } ], "crossref": [ { "id": "A0AAA9SKU6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07361", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07361", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EQEAQYG", "url": "https://omabrowser.org/oma/group/EQEAQYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11060:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11060:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01875", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01875", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6785631", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6785631", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJ89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLD8", "url": "https://www.uniprot.org/uniprotkb/F1MLD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLD8-1", "url": "https://www.uniprot.org/uniprotkb/F1MLD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 274, "header": "tr|A0AAA9SKU6-1|A0AAA9SKU6_BOVIN Isoform 1 of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=3 SV=1 CANONICAL=A0AAA9SKU6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#A0AAA9SJ89-1", "sequence": { "sequence": "MVGKTGDFPRGKLHRKALGAPGLRKLVGGGGLPCGCVLLPAPSSSPPLLPLNPGERSVHGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 336, "header": "tr|A0AAA9SJ89-1|A0AAA9SKU6_BOVIN Computationally mapped isoform of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=3 SV=1 CANONICAL=A0AAA9SKU6-1" }, "locus": { "chromosome": "11", "start_pos": 14656066, "end_pos": 14545701, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083972.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083972.1" } ] } }, { "isoform_ac": "A0AAA9SKU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#A0AAA9SKU6-1", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 274, "header": "tr|A0AAA9SKU6-1|A0AAA9SKU6_BOVIN Isoform 1 of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=3 SV=1 CANONICAL=A0AAA9SKU6-1" }, "locus": { "chromosome": "11", "start_pos": 14655101, "end_pos": 14545701, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103959.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103959.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084531.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084531.1" } ] } }, { "isoform_ac": "A0AAA9TC56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#A0AAA9TC56-1", "sequence": { "sequence": "MVGKTGDFPRGKLHRKALGAPGLRKLVGGGGLPCGCVLLPAPSSSPPLLPLNPGERSVHGGTGTKMSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 362, "header": "tr|A0AAA9TC56-1|A0AAA9TC56_BOVIN Computationally mapped isoform of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=3 SV=1 CANONICAL=A0AAA9SKU6-1" }, "locus": { "chromosome": "11", "start_pos": 14656066, "end_pos": 14545701, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088528.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088528.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095638.1" } ] } }, { "isoform_ac": "A0AAA9TDL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#A0AAA9TDL4-1", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 297, "header": "tr|A0AAA9TDL4-1|A0AAA9TDL4_BOVIN Computationally mapped isoform of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=3 SV=1 CANONICAL=A0AAA9SKU6-1" }, "locus": { "chromosome": "11", "start_pos": 14655101, "end_pos": 14545701, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117017.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117017.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094858.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094858.1" } ] } }, { "isoform_ac": "F1MLD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6/entry#F1MLD8-1", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNVILGMCSKFSF", "length": 265, "header": "tr|F1MLD8-1|A0AAA9SKU6_BOVIN Computationally mapped isoform of Protein MEMO1 OS=Bos taurus OX=9913 GN=MEMO1 PE=3 SV=4 CANONICAL=A0AAA9SKU6-1" }, "locus": { "chromosome": "11", "start_pos": 14655101, "end_pos": 14547068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010168.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010168.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010168.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010168.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6785631", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6785631", "resource": "Reactome", "description": "ERBB2 Regulates Cell Motility" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BNP5-1", "protein_name": "Protein MEMO1", "gene_name": "MEMO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 274 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y0E4-1", "protein_name": "Protein MEMO1", "gene_name": "MEMO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSNRVLCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPNITRKIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSEAKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMNIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAINELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALMVH", "length": 297 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q54NZ1-1", "protein_name": "Protein MEMO1 homolog", "gene_name": "memo1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIRNCTHAGSWYLDNARKLEKQLSDWLSEASRQNQNVKSIIAPHAGYSYSGRAAAYAYINLIPENYKRVFILGPSHHVYMKTCGLTKLDTWETPIGNLKVDKDTTNKLFDTGSFIWNTKSVDEDEHSLELQLPYIAKVAEKRLLELSIVPIMVGSLSIDLEELYGKILAPYFDDPENFFVISSDFCHWGERFGYTRYENKEVPIYKYIEELDRKGMEIIESGDPVQFSKYLKETKNTICGRCPIAVMLWITKNSQFKYNISSLYYEQSSKVIKSSDSSVSYGVLSFTKEN", "length": 290 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q91VH6-1", "protein_name": "Protein MEMO1", "gene_name": "Memo1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSVTRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRSWQDSSVSYAAGALTVH", "length": 297 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SIR5-1", "protein_name": "AmmeMemoRadiSam system protein B", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEKIRQPTHAGSWYTDNPTKLSSDLEEWLNATGLTKSPDVRGVIAPHAGYSYSGRAAAYAFANIDPTNISRIFLLGPSHHFYTPKCALSTATVYKTPIGNLPVDVEMIKEIRAMGKFGMMDLRVDEAEHSMEMHLPYLAKVFEGNNVKVVPILVGAVSPENEAMYGELLAKYVDDPKNFFSVSSDFCHWGSRFNYMHYDNTHGAIHKSIEALDKKGMDIIETGDPDAFKKYLLEFENTICGRHPISIFLHMLKHSSSKIKINFLRYEQSSQCQTMRDSSVSYASAAAKLET", "length": 291 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VG04-1", "protein_name": "Protein MEMO1", "gene_name": "dMEMO", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSARRATHAGSWYTDSGAELSRQLDRWLGAADLSHGPARAIIAPHAGYTYCGACAAFAYRQVSPVVVKRIFILGPSHHVRLRGCALSVAKKYRTPLYDLKIDAQINSELEKTGKFSWMDMKTDEDEHSIEMHLPYIAKVMEDYKDQFTIVPILVGSLNPEQEAQYGSLLSSYLMDPTNLFVISSDFCHWGHRFSYTYYDSSCGAIHKSIEKLDKQGMDIIESLNPHSFTEYLRKYNNTICGRHPIGVMLGAVKALQDQGYDKMSFKFLKYAQSSQCQDIEDSSVSYASGSLVFEM", "length": 295 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y316-1", "protein_name": "Protein MEMO1", "gene_name": "MEMO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH", "length": 297 }, "evidence": [ { "id": "A0AAA9SKU6", "url": "https://omabrowser.org/oma/group/A0AAA9SKU6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of microtubule-based process", "id": "GO:0032886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 242, "end_pos": 244 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ95-1", "uniprot_ac": "A0AAA9SJ95", "uniprot_id": "A0AAA9SJ95_BOVIN", "mass": { "chemical_mass": 250427.0, "monoisotopic_mass": 250427.0 }, "refseq": {}, "gene_names": [ { "name": "UNC13C", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ] } ], "protein_names": [ { "name": "Protein unc-13 homolog C", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95/entry#names_and_taxonomy" } ] }, { "name": "Munc13-3", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses.", "evidence": [ { "database": "UniProtKB", "id": "E1BBX9", "url": "https://www.uniprot.org/uniprotkb/E1BBX9#function" }, { "database": "UniProtKB", "id": "ARBA00053265", "url": "https://www.uniprot.org/uniprotkb/ARBA00053265#function" }, { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UNC13C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95", "locus": { "chromosome": "10", "start_pos": 55635538, "end_pos": 56319382, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025522", "url": "https://www.ensembl.org/id/ENSBTAG00000025522" } ] } } ], "crossref": [ { "id": "ENSBTAG00000025522", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025522", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04027", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04027", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08395", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08395", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20859", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20859", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AKYMCPS", "url": "https://omabrowser.org/oma/group/AKYMCPS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBX9", "url": "https://www.orthodb.org/?gene=E1BBX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10480", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10480", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10480:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10480:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06292", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06292", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBX9", "url": "https://www.uniprot.org/uniprotkb/E1BBX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBX9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVANVFKSLILPYIHKLCKGMFTKKLGNTTKKKENRQPKKDQDLPVAGQTKTPKFSNTLKSTVKKLAKCSSTRNLSTEEEEANKEFSLSPTFSYVAIANGLQKKIHVANGDHEELLQELSSIESSYSESLSELRSSTENQAQSALMMPVRRNRKSSSSLAPSEGSSDGERTLQSLKLGALRKLRKWKKSQECVSSDSELSTMKKTWGIRSKSLDRTARNPKTNALEPGFSSSVCISQTQDVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQNEIEQLRTGFVQSRRETRDIHDYIKHLGHVGSKASLRFLNVPEERFEYIESVVYQVLIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETPQQRDLVLKKSYKLKGTGIGISTDILTHDIKERKERGIPSSQTYESMDIKLSTPEPRLKNSWHSPDDSDGELASDLNRNSYAVLSKSEFPTKGSASKSSSKSHNARAKNKTASSSKIANKSEYDKLSSHLPESDNLAKQTTTHYADVTPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTPTMYDNPQDQGLNGAPLGVQGQSEIEYTETVDSGVSNGMVCASGDQSHYSDSQLSLHEDLSPWKEWNQEEQGADLGLDSSTQEAFDYDTNSLSDQPLDVYHKDLEDLGKGHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYNSYQEPNSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKAFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDYSEPVADNETDYVEVMEQVLAKLENRTSVTETDEQMPEYDHPSYETPYETPQDEGYDGQADDVVSEGGLEPLNEAPAEMQMKEDENQNIPEQPVEVTKPKRIRPSFKEAALKAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQAFGGAGRGLYGIDSMPDLRKKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKIHVFKKTLQALIYPMSSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCSECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIRETNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKANGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTISTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREHFPASNAERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLIDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFAQDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSYCDKENVPCILMNNIQQLRVQLEKVFESMGGKELDPEASTVLKELQVKLSGVLDELSVTYGESFQLIIEGCIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRPLMDFLDKTLSLSAKICERTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDAKGLTARQCGIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRPSKDSVGQISVHVDITATPGTGEHKVTVKVIAINDLNWQTTAMFRPFVEVCMLGPNLGDKKRKQGTKTKSNTWSPKYNETFQFTLSKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNVSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSAEENA", "length": 2215, "header": "tr|A0AAA9SJ95-1|A0AAA9SJ95_BOVIN Isoform 1 of Protein unc-13 homolog C OS=Bos taurus OX=9913 GN=UNC13C PE=3 SV=1 CANONICAL=A0AAA9SJ95-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95/entry#A0AAA9SJ95-1", "sequence": { "sequence": "MVANVFKSLILPYIHKLCKGMFTKKLGNTTKKKENRQPKKDQDLPVAGQTKTPKFSNTLKSTVKKLAKCSSTRNLSTEEEEANKEFSLSPTFSYVAIANGLQKKIHVANGDHEELLQELSSIESSYSESLSELRSSTENQAQSALMMPVRRNRKSSSSLAPSEGSSDGERTLQSLKLGALRKLRKWKKSQECVSSDSELSTMKKTWGIRSKSLDRTARNPKTNALEPGFSSSVCISQTQDVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQNEIEQLRTGFVQSRRETRDIHDYIKHLGHVGSKASLRFLNVPEERFEYIESVVYQVLIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETPQQRDLVLKKSYKLKGTGIGISTDILTHDIKERKERGIPSSQTYESMDIKLSTPEPRLKNSWHSPDDSDGELASDLNRNSYAVLSKSEFPTKGSASKSSSKSHNARAKNKTASSSKIANKSEYDKLSSHLPESDNLAKQTTTHYADVTPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTPTMYDNPQDQGLNGAPLGVQGQSEIEYTETVDSGVSNGMVCASGDQSHYSDSQLSLHEDLSPWKEWNQEEQGADLGLDSSTQEAFDYDTNSLSDQPLDVYHKDLEDLGKGHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYNSYQEPNSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKAFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDYSEPVADNETDYVEVMEQVLAKLENRTSVTETDEQMPEYDHPSYETPYETPQDEGYDGQADDVVSEGGLEPLNEAPAEMQMKEDENQNIPEQPVEVTKPKRIRPSFKEAALKAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQAFGGAGRGLYGIDSMPDLRKKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKIHVFKKTLQALIYPMSSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCSECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIRETNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKANGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTISTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREHFPASNAERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLIDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFAQDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSYCDKENVPCILMNNIQQLRVQLEKVFESMGGKELDPEASTVLKELQVKLSGVLDELSVTYGESFQLIIEGCIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRPLMDFLDKTLSLSAKICERTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDAKGLTARQCGIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRPSKDSVGQISVHVDITATPGTGEHKVTVKVIAINDLNWQTTAMFRPFVEVCMLGPNLGDKKRKQGTKTKSNTWSPKYNETFQFTLSKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNVSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSAEENA", "length": 2215, "header": "tr|A0AAA9SJ95-1|A0AAA9SJ95_BOVIN Isoform 1 of Protein unc-13 homolog C OS=Bos taurus OX=9913 GN=UNC13C PE=3 SV=1 CANONICAL=A0AAA9SJ95-1" }, "locus": { "chromosome": "10", "start_pos": 56299963, "end_pos": 55637086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083977.1" } ] } }, { "isoform_ac": "E1BBX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95/entry#E1BBX9-1", "sequence": { "sequence": "MMPVRRNRKSSSSLAPSEGSSDGERTLQSLKLGALRKLRKWKKSQECVSSDSELSTMKKTWGIRSKSLDRTARNPKTNALEPGFSSSVCISQTQDVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQNEIEQLRTGFVQSRRETRDIHDYIKHLGHVGSKASLRFLNVPEERFEYIESVVYQVLIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETPQQRDLVLKKSYKLKGTGIGISTDILTHDIKERKERGIPSSQTYESMDIKLSTPEPRLKNSWHSPDDSDGELASDLNRNSYAVLSKSEFPTKGSASKSSSKSHNARAKNKTASSSKIANKSEYDKLSSHLPESDNLAKQTTTHYADVTPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTPTMYDNPQDQGLNGAPLGVQGQSEIEYTETVDSGVSNGMVCASGDQSHYSDSQLSLHEDLSPWKEWNQEEQGADLGLDSSTQEAFDYDTNSLSDQPLDVYHKDLEDLGKGHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYNSYQEPNSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKAFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDYSEPVADNETDYVEVMEQVLAKLENRTSVTETDEQMPEYDHPSYETPYETPQDEGYDGQADDVVSEGGLEPLNEAPAEMQMKEDENQNIPEQPVEVTKPKRIRPSFKEAALKAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQAFGGAGRGLYGIDSMPDLRKKKTLPIVRDVVKTLAARKSGLSLAMVIRTSLNNEELKIHVFKKTLQALIYPMSSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCSECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIRETNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKANGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTISTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYREHFPASNAERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLIDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFAQDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSYCDKENVPCILMNNIQQLRVQLEKVFESMGGKELDPEASTVLKELQVKLSGVLDELSVTYGESFQLIIEGCIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRPLMDFLDKTLSLSAKICERTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDAKGLTARQCGIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRPSKDSVGQISVHVDITATPGTGEHKVTVKVIAINDLNWQTTAMFRPFVEVCMLGPNLGDKKRKQGTKTKSNTWSPKYNETFQFTLSKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNVSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSAEENA", "length": 2070, "header": "tr|E1BBX9-1|E1BBX9_BOVIN Computationally mapped isoform of Protein unc-13 homolog C OS=Bos taurus OX=9913 GN=UNC13C PE=3 SV=3 CANONICAL=A0AAA9SJ95-1" }, "locus": { "chromosome": "10", "start_pos": 56299525, "end_pos": 55637086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002162.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002162.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002162.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002162.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LSN2-1", "protein_name": "Protein unc-13 homolog C", "gene_name": "Unc13c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVASLFKSLILAYLHKLCKGMFTKKLGNTTKKKENHPQKKNQDFPTAGHTKPPKLSNALKSTVKKIAKCSSTRNFSVEDDEGHKDFSLSPTFSYRVAIANGLQTAVTNSDEDLLQELSSIESSYSESFNELRSSTENQGQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHTLKLGALRKLRKWKKSQECVSSDSELSTVKKTWGIRSKSLDRTARNPKTNVLEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKYSIDEISSSVEVVQSEIEQLRTGFVQARRETRDIHDYIKHLGHMGSKVSLRFLNVPEERLEYVESVVYQILVDKMGFSDVPNSIKIEFAQRIGQQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTYDIRERKEKGGLPSSQTYESMDMKLSTPEPKAKKNSWLSPNDSDRELESDISRSSYADSTAKGNTSKPSSKSHSARSKNKAANNRTSHKSDYDKRPSQLPASNTPEKQTAHYMEATPLWHSQSDFFTPKLSRSESDFSKLCQSYSEDFSENQFFCRTNGSSLLSSSDRELWQRKQESMSALYHSPQDHGLDRSIPAVQGQSEIENTETVDSGMSNSMVCASGDRSNYSGSQLSLHEDLSPWKEWNQAEQAADVGLDSSTQEPFDYDTNSLSDQQLDVFSKDLDDLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGPYDSYQETNSNELYPNQSQPAMMYRSQSELQSDDSEGAPPKSWHSRLSIDLSDKTFKFPKFGSTLQRAKSALEVVWNKSTQSLSGCEDSGSSLMGRFRTLSQSTANESSTTLDSDIYTEPYYYKAEEEEDYSEPVADSETDYVEVMEQVLAKLENRTSVTEVDEHVKDYDHPSYETPYETPQDEGYDGQADDIISEGELETLNEPAVEMELAEDENQNLPVEPPEIMKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQVFGGAGRGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPISSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTLTIITAMKERMKIRERNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDERFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGRVKIPEVKGDEAWKVFFDDASQEIVDEFAIRYGVESIYQAMTHFSCLSSKYMCPGVPAVMSALLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPKASAVVKDCVRACLDSTYKYIFDNCHELYSQLIDPGKKQDVPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWSLFALDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLVQYAAIVSSDFSSYCDKETVPCILMNNIQQLRVQLEKMFESMGGKELDPEASTILKELQIKLNGVLDELSITYGESFQLVIEECIKQMGAELNQMRANGNSTANKNSTAMDAETALRPLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDAKGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLHSLRYALSLYTQTTDALIKKFIETQSSQSRSSKDSVGQISVHVDVTTTPGTGEHKVTVKVIAINDLNWQTTAMFRPFVEVCMLGPSLGDKRRKQGTKTKSNTWSPKYNETFQFILGNENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNLSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSIEESA", "length": 2208 }, "evidence": [ { "id": "A0AAA9SJ95", "url": "https://omabrowser.org/oma/group/A0AAA9SJ95/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZSY8-1", "protein_name": "Unc-13 homolog C", "gene_name": "LOC415414", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVSSCLKSLISSYIYKICKGMFTKKLGNSTKRKESCQSKKEQDLTPTGQIKNPKFSNTLKSTVKKIAKCPSARNLSTEEEEGNREFSLSPTFSYRVAIANGLQKHVFVTNNNNEDLTQDLSSNDSSYSDSLSEVKSNIKKNEYFSYTMPVRRNRKSLSSLAASDGSSDGERTLHTLKLGALRKLRKWKKSQECVSSDSELSTWKKTWGLRSKSLDRTGRHQKSNTLEPGFSSTGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKQSIDEISSSVEVVQNEIEQLRTGFVQSRRETRDIHDYIKQIGHPGNKASLRFLNVPEERLEKTENIVYKILIEKMGFSEAQSTIKIEFAQRLGQQRDCPNAKPRPILVYFESSQQRDLLLKKSYKLKGTGIGISTDVFAHDIKEKKERGLPSSQTYESMDMKIVTVETKTKMHDWESPDSDKDVESDINKNSYAKVSKSALQIKTSTTKGNAESPDPKDLNRTADNNTFSNRRNYDSQSPEFDNVEKQPKMYYSDMTPLWHLQNDFAAPKLSRSESDFSKLCQSYSEDFSENQYFSKTNGSSLLSSSDRELWQRRQDDSVNWYGSSQEQTFAQDAQQYPEQNEVENTETVDSGLSNGIMCVSRDRSHYSDSQLSLHDDFSPWKDWNQLEQGADLGLDSSTQEVFVYDMSSPSDQQTDFGKCRSSDLQYDTESYDFTLDGTSPSCAGLDSESQSQWTSQYDDYQETNSKSPYQNQNRLPMMYRSQSELPSDDSEEAAPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSFIGRFRTLSQSTANESSTTLDSDVYAEPYCYKAEYEEDLIEPPGENETDYVEVMEQVLAKLENRTNSSETSEQVQEYELGQPPCGSPYAILPEEQYDGQFNGLVSEEILEVESDMDAHMDAHVEIREDENQNVQEMLTEIPKKKRIRPSFKEAALKAYKKQMNDLEDKILSGDSGSVDEKARIVSGSSLDTSKLYAIQAFSGSGRGLYGIDSMPDLRRKKSFPIVRDVAMTLAARKSGISMAMLIRTSINNEEMKIHVFKKTLQALIYPISSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQNIISAMKERMKIREKNRPEVFEVIQEMFDISKEDFVQYTKAAKQSVLDGTSKWSAKITITVLCAQGLQAKDKTGSSDPYVTVQVGKTKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGALRLKINVEIEGEEKVAPYHVQYTCLHENLFHYLTEVKSNGVVKIPEVRGDDAWKVYFDDAAQEIVDEFAMRYGIEYIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTATTNVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRDNFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPRASTVVKDCVRACLDSTYRYIFDNCYDLYSQLIDQGKKQEVPKEEQGPTTKNLDFWAQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFAQDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELHAFKDAVPEYSLWFEPFVIQWLDENEDVSMEFLHGALERDKKDGFQQTSDHALFSCSVVDVFTQLNQSFEIIRKLECPNPEALSHLMRRFAKTINKVLLQYAAIISSYFSSYCDKENVPCILMNNIQQLRVQLEKMFESMGGKEKKEGERFSYELDQEASTVLKELQAKLSNVLDELSVTYATSFQSIIEDCVRQMSSELNQMRGNGTAAANKNSAAIDAEIVLRPLMDFLDKTLSLSAKICEKTVLKRVLKELWKIVLNRIEKQIVLPPLTDQTGPQMIFSAAKDLGQLSKLKDHVIRDDAKSLTLRQCAIMEVALATIKQYFHAGGSGLKKNFLEKSPDLHSLKYALSLYTQTTDALIKKFIDTQKSQSQTTNNSVGEISVQVDVSTHPGTGEHKVTVKVVAINNLNWQTTAMFRPFVEVCVLGPNLSDKKRKHGTKTKSNTWSPKYNETFQFILSNEDKPGAYELHLSVKDYCFAREDRVIGMTVIQLQNIAEKGSCASWYPLLRNIFVDETGLTILRILSQRTNDEVAKEFVRLKSETRSAEETA", "length": 2220 }, "evidence": [ { "id": "A0AAA9SJ95", "url": "https://omabrowser.org/oma/group/A0AAA9SJ95/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q62770-1", "protein_name": "Protein unc-13 homolog C", "gene_name": "Unc13c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVASLFKSLILAYIHKLCKGMFTKKLGNTTKKKENRQQNKDQDFPTAGHTKPPKLSNALKSTVKKIAKCSSTRNFSVEDEEGHKDFSLSPTFSYRVAIANGLQTAVTNSDEDLLQELSSIESSYSESFNELRSSTENQVQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHTLKLGALRKLRKWKKSQECVSSDSELSTVKKTWGIRSKSLDRTARNPKTNVLEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKYSIDEISSSVEVVQSEIEQLRTGFVQARRETRDIHDYIKHLGHMGSKVSLRFLNVPEERHEYVESVVYQILVDKMGFSDVPNAIKIEFAQRIGQQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIAISTDILTYDIRERKEKGVLPSSQTYESMDMKLSTPEPKAKKNAWLSPNDSDRELESDLSRSSYADSPAKGSSSKSSSKSHSARSKNKAANSRTSQKSDYNKRPSKPPASEKPTPHYVEATPLWHSQSDFFTPKLSRSESDFSKLCQSYSEDFSESQFFCRTNGSSLLSSSDRELWQRKQEGMTALYHSPQDQGLDGNIPTVPGQGEIENTETVDSGMSNSVVCASGDRSNYSGSQLSLHEDLSPWKEWNQAGHGTDGLDSSTQEPFDYDTNSLSDQQLDMSSKDLDDLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQKTNSNDLYPNQSHPSMMYRSQSELQSDDSEAAQPKSWHSRLSIDLSDKTFKFPKFGSTLQRAKSALEVVWNKSTQSLSGCEDSGSSLMGRFRTLSQSTANESSTTLDSDIYTEPYYYKAEEEEDYCEPVADSETDYVEVMEQVLAKLENRTSVTEVDEHIKEYDHPSYETPYETPQDEGYDGQADDIISEGELETLNEPAVEMELVEDESQNLPVEPPEVMKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQVFGGAGRGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFRKTLQALIYPISSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIRERNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGSVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGVESIYQAMTHFSCLSSKYMCPGVPAVMSALLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPKASAVVKDCVRACLDSTYKYIFDNCHELYSQLIDPSKKQDVPREEQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWSLFALDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLVQYAAIVSSDFSSYCDKETVPCILMNNIQQLRVQLEKMFESMGGKELDPEASTILKELQIKLNGVLDALSVTYGESFQLVIEECIKQMGAELNQMRANGNSAANKNNAAMDAEIVLRPLMDFLDKILSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKELGQLSKLKEHMIRDDAKGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLHSLRYALSLYTQTTDALIKKFIETQGSQSRSSKDAVGQISVHVDVTTTPGTGEHKVTVKVIAINDLNWQTTTMFRPFVEVCMLGPSLGDKKRKQGTKTKSNTWSPKYNETFQFILGNENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNLSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSIDESA", "length": 2204 }, "evidence": [ { "id": "A0AAA9SJ95", "url": "https://omabrowser.org/oma/group/A0AAA9SJ95/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K0T7-1", "protein_name": "Protein unc-13 homolog C", "gene_name": "Unc13c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVASLFKSLILAYIHKLCKGMFTKKLGNTTKKKENRQQKKDQDFPTAGHTKPPKLSNALKSTVKKIAKCSSTRNFSIEDEEGHKDFSLSPTFSYRVAIANGLQTAVTNSDEDLLQELSSIESSYSESFNELRSSTENQVQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHTLKLGALRKLRKWKKSQECVSSDSELSTVKKTWGIRSKSLDRTARNPKTNVLEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKYSIDEISSSVEVVQSEIEQLRTGFVQARRETRDIHDYIKHLGHMGSKVSLRFLNVPEERHEYVESVVYQILIDKMGFSDVPNAIKIEFAQRIGQQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTYDIRERKEKGVLPSSQTYESMDMKLSTPEPKAKKNAWLSPNDSDRELESDLSRSSYADSPAKGSSSKSSSKSHSARSKNKAANSRTSQKSDYNKRPSQPPASSTPEKQTPHYVEATPPLWHSQSDFFTLKLSRSESDFSKLCQSYSEDFSESQFFCRTNGSSLLSSSDRELWQRKQEGMPALYHRLQDQGLDETIPAVPGQAEIENTETVDSGMSNSMVCASGDRSNYSGSQLSLHEDLSPWKEWNQAGQGTDDVGLDSSTQEPFDYDTNSLSDQQLDLSSKDLDDLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQEANSNDLYPNQSHPSMMYRSQSELQSDDSEGAQPKSWHSRLSIDLSDKTFKFPKFGSTLQRAKSALEVVWNKSTQSLSGCEDSGSSLMGRFRTLSQSTANESSTTLDSDIYTEPYYYKAEEEEDYCEPVADSETDYVEVMEQVLAKLENRTSITEVNEHIKDYDHPSYETPYETPQDEGYDGQADDIISEGELETLNEPAVEMELAEDENQNLPAESLEVMKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSMDEKARIVSGNDLDASKFSALQVFGGAGRGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFRKTLQALIYPISSTTPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIRERNRPEVFEVIQEMFQISKEDFVQYTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFFFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGSVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGVESIYQAMTHFSCLSSKYMCPGVPAVMSALLANINAFYAHTTVSTNVQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNSERLQDLKSTVDLLTSITFFRMKVLELQSPPKASAVVKDCVRACLDSTYKYIFDNCHELYSQLIDPSKKQDVPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWSLFALDMKYALEEHEKQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSDHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLVQYAAIVSNDFSSYCDKETVPCILMNNIQQLRVQLEKMFESMGGKELDPEASTILKELQIKLNGVLDALSITYGESFQLTIEECIKQMGAELNQMRANGNSTANKNSAAMDAEIVLRPLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDAKGLTPRQCAIVEVVLATIKQYFHAGGNGLKKNFLEKSPDLHSLRYALSLYTQTTDALIKKFIETQGSQSRSSKDAVGQISVHVDVTTTPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCMLGPSLGDKKRKQGTKTKSNTWSPKYNETFQFILGNENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNLSMDETGLTILRILSQRTSDDVAKEFVRLKSETRSIEESA", "length": 2210 }, "evidence": [ { "id": "A0AAA9SJ95", "url": "https://omabrowser.org/oma/group/A0AAA9SJ95/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NB66-1", "protein_name": "Protein unc-13 homolog C", "gene_name": "UNC13C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVANFFKSLILPYIHKLCKGMFTKKLGNTNKNKEYRQQKKDQDFPTAGQTKSPKFSYTFKSTVKKIAKCSSTHNLSTEEDEASKEFSLSPTFSYRVAIANGLQKNAKVTNSDNEDLLQELSSIESSYSESLNELRSSTENQAQSTHTMPVRRNRKSSSSLAPSEGSSDGERTLHGLKLGALRKLRKWKKSQECVSSDSELSTMKKSWGIRSKSLDRTVRNPKTNALEPGFSSSGCISQTHDVMEMIFKELQGISQIETELSELRGHVNALKHSIDEISSSVEVVQSEIEQLRTGFVQSRRETRDIHDYIKHLGHMGSKASLRFLNVTEERFEYVESVVYQILIDKMGFSDAPNAIKIEFAQRIGHQRDCPNAKPRPILVYFETPQQRDSVLKKSYKLKGTGIGISTDILTHDIRERKEKGIPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRNSYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDYDKISSQLPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLGLDSSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEPQGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDDSEDAPPKSWHSRLSIDLSDKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGSSLMGRFRTLSQSTANESSTTLDSDVYTEPYYYKAEDEEDYTEPVADNETDYVEVMEQVLAKLENRTSITETDEQMQAYDHLSYETPYETPQDEGYDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPEQPVEITKPKRIRPSFKEAALRAYKKQMAELEEKILAGDSSSVDEKARIVSGNDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDFVQFTKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGGVKIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMSTLLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHELYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNMGKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVPEYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQLNQSFEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQLRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQMSFELNQMRANGNTTSNKNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELWKLVLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVLATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDAVGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQGTKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEKGSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA", "length": 2214 }, "evidence": [ { "id": "A0AAA9SJ95", "url": "https://omabrowser.org/oma/group/A0AAA9SJ95/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "calyx of Held", "id": "GO:0044305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044305", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "parallel fiber to Purkinje cell synapse", "id": "GO:0098688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098688", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "terminal bouton", "id": "GO:0043195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043195", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "diacylglycerol binding", "id": "GO:0019992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019992", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "syntaxin-1 binding", "id": "GO:0017075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017075", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "synaptic vesicle exocytosis", "id": "GO:0016079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016079", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "negative regulation of synaptic plasticity", "id": "GO:0031914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "synaptic transmission, glutamatergic", "id": "GO:0035249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "synaptic vesicle priming", "id": "GO:0016082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "synaptic vesicle docking", "id": "GO:0016081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016081", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" }, { "name": "dense core granule priming", "id": "GO:0061789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1278, "end_pos": 1280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1742, "end_pos": 1744, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1874, "end_pos": 1876, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2116, "end_pos": 2118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2175, "end_pos": 2177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 491, "end_pos": 493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 720, "end_pos": 722, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" }, { "start_pos": 814, "end_pos": 816, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 875, "end_pos": 877, "annotation": "n_glycosylation_sequon" }, { "start_pos": 892, "end_pos": 894, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 1204, "end_pos": 1328, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" }, { "id": "PS51258", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51258" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MHD1", "eco_id": "ECO_0000259", "start_pos": 1638, "end_pos": 1781, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" }, { "id": "PS51259", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51259" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MHD2", "eco_id": "ECO_0000259", "start_pos": 1887, "end_pos": 2029, "start_aa": "Glu", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ95" }, { "id": "PS50081", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50081" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phorbol-ester/DAG-type", "eco_id": "ECO_0000259", "start_pos": 1098, "end_pos": 1148, "start_aa": "Pro", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1278, "end_pos": 1280 }, { "start_pos": 1742, "end_pos": 1744 }, { "start_pos": 1874, "end_pos": 1876 }, { "start_pos": 2116, "end_pos": 2118 }, { "start_pos": 2175, "end_pos": 2177 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 491, "end_pos": 493 }, { "start_pos": 501, "end_pos": 503 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 720, "end_pos": 722 }, { "start_pos": 74, "end_pos": 76 }, { "start_pos": 814, "end_pos": 816 }, { "start_pos": 843, "end_pos": 845 }, { "start_pos": 875, "end_pos": 877 }, { "start_pos": 892, "end_pos": 894 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJ96-1", "uniprot_ac": "A0AAA9SJ96", "uniprot_id": "A0AAA9SJ96_BOVIN", "mass": { "chemical_mass": 74284.0, "monoisotopic_mass": 74284.0 }, "refseq": {}, "gene_names": [ { "name": "ADCK5", "type": "recommended", "evidence": [ { "id": "A0AAA9SJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96" } ] } ], "protein_names": [ { "name": "AarF domain containing kinase 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJ96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADCK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96", "locus": { "chromosome": "14", "start_pos": 556899, "end_pos": 570622, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011064", "url": "https://www.ensembl.org/id/ENSBTAG00000011064" } ] } } ], "crossref": [ { "id": "A0AAA9SJ96", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJ96", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13969", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13969", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N2C7", "url": "https://www.orthodb.org/?gene=F1N2C7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43173", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43173", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43173:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43173:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03109", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03109", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJ96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2C7", "url": "https://www.uniprot.org/uniprotkb/F1N2C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2C7-1", "url": "https://www.uniprot.org/uniprotkb/F1N2C7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWRPVRPRALAPLPRPGSPSRDPQGPRLAPQGSSRLAGARHSRQAACPRVPASAPRPCEGDIGPSPPHAAAPLFRGYFLAQLCHFHSALLQGRPKPWPSPATFFRRNLAAPPARPLRPQPLWRKALSAAALGAPLLLGVRYLTAGAQERRRMRLVVDGIGRFSRSLRVGLQISLDYWWCTNVILRGVEENSPRYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYIRTLRVLEDRALTRGFREVDELFLEDFQAPPHELFQEFDYQPIAAASLAQVHRARLHDGTVVAVKPPVQVQYIDLRDRFDGDIHTLELLLHLVELMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELQHFRHVVVPRVHWGTSSKRVLTAEFYEGCKVNDVEAIQSMGLAVQDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAQLVLLDHGLYQFLDEKDRLALCQLWRAIILRDEAAMKAHAAELGVQDYLLFSEVLMQRPVRLGQLWRSRLLSREEAAYMQDMAREHFEEVMAVLKALPRSMLLVLRNVNTVRSINNALGAPVDRYFLMAKSAVRGWSRLAGAMYQSIYGASILRHIRVIWETFKFEVALRLETLSMRLTALLVRVLVYLGIMPDTKGLSKYLET", "length": 659, "header": "tr|A0AAA9SJ96-1|A0AAA9SJ96_BOVIN Isoform 1 of AarF domain containing kinase 5 OS=Bos taurus OX=9913 GN=ADCK5 PE=3 SV=1 CANONICAL=A0AAA9SJ96-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96/entry#A0AAA9SJ96-1", "sequence": { "sequence": "MWRPVRPRALAPLPRPGSPSRDPQGPRLAPQGSSRLAGARHSRQAACPRVPASAPRPCEGDIGPSPPHAAAPLFRGYFLAQLCHFHSALLQGRPKPWPSPATFFRRNLAAPPARPLRPQPLWRKALSAAALGAPLLLGVRYLTAGAQERRRMRLVVDGIGRFSRSLRVGLQISLDYWWCTNVILRGVEENSPRYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYIRTLRVLEDRALTRGFREVDELFLEDFQAPPHELFQEFDYQPIAAASLAQVHRARLHDGTVVAVKPPVQVQYIDLRDRFDGDIHTLELLLHLVELMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELQHFRHVVVPRVHWGTSSKRVLTAEFYEGCKVNDVEAIQSMGLAVQDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAQLVLLDHGLYQFLDEKDRLALCQLWRAIILRDEAAMKAHAAELGVQDYLLFSEVLMQRPVRLGQLWRSRLLSREEAAYMQDMAREHFEEVMAVLKALPRSMLLVLRNVNTVRSINNALGAPVDRYFLMAKSAVRGWSRLAGAMYQSIYGASILRHIRVIWETFKFEVALRLETLSMRLTALLVRVLVYLGIMPDTKGLSKYLET", "length": 659, "header": "tr|A0AAA9SJ96-1|A0AAA9SJ96_BOVIN Isoform 1 of AarF domain containing kinase 5 OS=Bos taurus OX=9913 GN=ADCK5 PE=3 SV=1 CANONICAL=A0AAA9SJ96-1" }, "locus": { "chromosome": "14", "start_pos": 570430, "end_pos": 557023, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107702.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107702.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085407.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085407.1" } ] } }, { "isoform_ac": "A0AAA9SYA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96/entry#A0AAA9SYA9-1", "sequence": { "sequence": "MWRPAQLCHFHSALLQGRPKPWPSPATFFRRNLAAPPARSLRVGLQISLDYWWCTNVILRGVEENSPRYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYIRTLRVLEDRALTRGFREVDELFLEDFQAPPHELFQEFDYQPIAAASLAQVHRARLHDGTVVAVKVQYIDLRDRFDGDIHTLELLLHLVELMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELQHFRHVVVPRVHWGTSSKRVLTAEFYEGCKVNDVEAIQSMGLAVQDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAQLVLLDHGLYQFLDEKDRLALCQLWRAIILRDEAAMKAHAAELGVQDYLLFSEVLMQRPVRLGQLWRSRLLSREEAAYMQDMAREHFEEVMAVLKALPRSMLLVLRNVNTVRSINNALGAPVDRYFLMAKSAVRGWSRLAGAMYQSIYGASILRHIRVIWETFKFEVALRLETLSMRLTALLVRVLVYLGIMPDTKGLSKYLET", "length": 530, "header": "tr|A0AAA9SYA9-1|A0AAA9SYA9_BOVIN Computationally mapped isoform of AarF domain containing kinase 5 OS=Bos taurus OX=9913 GN=ADCK5 PE=3 SV=1 CANONICAL=A0AAA9SJ96-1" }, "locus": { "chromosome": "14", "start_pos": 570430, "end_pos": 557023, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131563.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131563.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089242.1" } ] } }, { "isoform_ac": "F1N2C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96/entry#F1N2C7-1", "sequence": { "sequence": "MWRPAQLCHFHSALLQGRPKPWPSPATFFRRNLAAPPARPLRPQPLWRKALSAAALGAPLLLGVRYLTAGAQERRRMRLVVDGIGRFSRDCAPCCPGHPSSAYRDRGVACVQAAQCPAQELRWTCWLCSPESPAASPRSLRVGLQISLDYWWCTNVILRGVEENSPRYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYIRTLRVLEDRALTRGFREVDELFLEDFQAPPHELFQEFDYQPIAAASLAQVHRARLHDGTVVAVKVQYIDLRDRFDGDIHTLELLLHLVELMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELQHFRHVVVPRVHWGTSSKRVLTAEFYEGCKVNDVEAIQSMGLAVQDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAQLVLLDHGLYQFLDEKDRLALCQLWRAIILRDEAAMKAHAAELGVQDYLLFSEVLMQRPVRLGQLWRSRLLSREEAAYMQDMAREHFEEVMAVLKALPRSMLLVLRNVNTVRSINNALGAPVDRYFLMAKSAVRGWSRLAGAMYQSIYGASILRHIRVIWETFKFEVALRLETLSMRLTALLVRVLVYLGIMPDTKGLSKYLET", "length": 629, "header": "tr|F1N2C7-1|A0AAA9SJ96_BOVIN Computationally mapped isoform of AarF domain containing kinase 5 OS=Bos taurus OX=9913 GN=ADCK5 PE=3 SV=2 CANONICAL=A0AAA9SJ96-1" }, "locus": { "chromosome": "14", "start_pos": 570430, "end_pos": 557023, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014692.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014692.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014692.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014692.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ96" }, { "id": "PF03109", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03109" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC1 atypical kinase-like", "eco_id": "ECO_0000259", "start_pos": 245, "end_pos": 493, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJA3-1", "uniprot_ac": "A0AAA9SJA3", "uniprot_id": "A0AAA9SJA3_BOVIN", "mass": { "chemical_mass": 137284.0, "monoisotopic_mass": 137284.0 }, "refseq": { "ac": "NP_001193000", "name": "tau-tubulin kinase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193000" }, "gene_names": [ { "name": "TTBK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "name": "TTBK2", "type": "synonym", "evidence": [ { "id": "NP_001193000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193000" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3/entry#names_and_taxonomy" } ] }, { "name": "tau-tubulin kinase 2", "type": "synonym", "evidence": [ { "id": "NP_001193000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193000" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTBK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3", "locus": { "chromosome": "10", "start_pos": 38038979, "end_pos": 38167982, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006470", "url": "https://www.ensembl.org/id/ENSBTAG00000006470" } ] } } ], "crossref": [ { "id": "A0AAA9SJA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006470", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006470", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14129", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14129", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541215", "url": "https://www.ncbi.nlm.nih.gov/gene/541215", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BJC2", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BJC2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541215", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541215", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DPLHQRQ", "url": "https://omabrowser.org/oma/group/DPLHQRQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJC2", "url": "https://www.orthodb.org/?gene=E1BJC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193000", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJC2", "url": "https://www.uniprot.org/uniprotkb/E1BJC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLEHISSLDYFTKPDYQLLTSVFDNSIKAFGVIESDPFDWEKTGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDMLRENTDEVFPDEQLSDGENGIPVGVSPNKVPGSLGHPHPQEKDVWEEMDTNRNKIKLGICKAATEEENSHGQANGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLALEPKPDTDKFLETCLEKMQKDPSAGKESTLPALLHKPCVPAVSRADHIWHYDEEYLPDASKPASVNTPEQADGGGSNGFVAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEALGPKTTGSPSDEEPEVLQVLEESPQDEKLQLGPWAENDHLKKETSGVVFVLSGECPATAASEQYIDRLEFQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGQQPEKKDLHTIEPTVELYSPRENFSGLVVIEGEPPSGGSRTDLGLQIDHIGHDMLPNIREYDRSQDVGPKDLPDHNRLAMREFEGLPRGLEEKSIALGSDNEDEKLSKGQHYIEISPLPGDLVTMERDHSATTEPLDVTKMQTFSVVPNQDKNHEIMKLLAVGSSEVSPRVIDPYVEEQIGQVAAMQKSKISEDDIKGEDLPNHSGDLSTFLHQEGKREKIAPRKGELFNPVSESEHCPPSRKDVVRSSFVTRHSRIPVLAQEIDSTFDSSSPVSAKEKLLQKKACQPDLVKLLVEKRQLRSLLGDLSSASDKLLEERLATVPAPFSEEEVFTPFSRLAADSHLSRSAEDNFLAPIISQSRKSKIPRPVSWVNTDQVNSSTPSQFLPRPPPGKPPMRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGTPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSFHHHSASTKAPPGKSKSASKLSR", "length": 1243, "header": "tr|A0AAA9SJA3-1|A0AAA9SJA3_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=TTBK2 PE=3 SV=1 CANONICAL=A0AAA9SJA3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3/entry#A0AAA9SJA3-1", "sequence": { "sequence": "MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLEHISSLDYFTKPDYQLLTSVFDNSIKAFGVIESDPFDWEKTGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDMLRENTDEVFPDEQLSDGENGIPVGVSPNKVPGSLGHPHPQEKDVWEEMDTNRNKIKLGICKAATEEENSHGQANGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLALEPKPDTDKFLETCLEKMQKDPSAGKESTLPALLHKPCVPAVSRADHIWHYDEEYLPDASKPASVNTPEQADGGGSNGFVAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEALGPKTTGSPSDEEPEVLQVLEESPQDEKLQLGPWAENDHLKKETSGVVFVLSGECPATAASEQYIDRLEFQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGQQPEKKDLHTIEPTVELYSPRENFSGLVVIEGEPPSGGSRTDLGLQIDHIGHDMLPNIREYDRSQDVGPKDLPDHNRLAMREFEGLPRGLEEKSIALGSDNEDEKLSKGQHYIEISPLPGDLVTMERDHSATTEPLDVTKMQTFSVVPNQDKNHEIMKLLAVGSSEVSPRVIDPYVEEQIGQVAAMQKSKISEDDIKGEDLPNHSGDLSTFLHQEGKREKIAPRKGELFNPVSESEHCPPSRKDVVRSSFVTRHSRIPVLAQEIDSTFDSSSPVSAKEKLLQKKACQPDLVKLLVEKRQLRSLLGDLSSASDKLLEERLATVPAPFSEEEVFTPFSRLAADSHLSRSAEDNFLAPIISQSRKSKIPRPVSWVNTDQVNSSTPSQFLPRPPPGKPPMRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGTPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSFHHHSASTKAPPGKSKSASKLSR", "length": 1243, "header": "tr|A0AAA9SJA3-1|A0AAA9SJA3_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=TTBK2 PE=3 SV=1 CANONICAL=A0AAA9SJA3-1" }, "locus": { "chromosome": "10", "start_pos": 38129334, "end_pos": 38039983, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107168.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107168.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086345.1" } ] } }, { "isoform_ac": "A0AAA9TBW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3/entry#A0AAA9TBW1-1", "sequence": { "sequence": "MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLEHISSLDYFTKPDYQLLTSVFDNSIKAFGVIESDPFDWEKTGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDMLRENTDEVFPDEQLSDGENGIPVGVSPNKVPGSLGHPHPQEKDVWEEMDTNRNKIKLGICKAATEEENSHGQANGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLALEPKPDTDKFLETWYKMIFFFQ", "length": 478, "header": "tr|A0AAA9TBW1-1|A0AAA9TBW1_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=TTBK2 PE=3 SV=1 CANONICAL=A0AAA9SJA3-1" }, "locus": { "chromosome": "10", "start_pos": 38129334, "end_pos": 38054828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123544.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123544.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093577.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093577.1" } ] } }, { "isoform_ac": "E1BJC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3/entry#E1BJC2-1", "sequence": { "sequence": "MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLEHISSLDYFTKPDYQLLTSVFDNSIKAFGVIESDPFDWEKTGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDMLRENTDEVFPDEQLSDGENGIPVGVSPNKVPGSLGHPHPQEKDVWEEMDTNRNKIKLGICKAATEEENSHGQANGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLALEPKPDTDKFLETCLEKMQKDPSAGKESTLPALLHKPCVPAVSRADHIWHYDEEYLPDASKPASVNTPEQADGGGSNGFVAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEALGPKTTGSPSDEEPEVLQVLEESPQDEKLQLGPWAENDHLKKETSGVVFVLSGECPATAASEQYIDRLEFQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGQQPEKKDLHTIEPTVELYSPRENFSGLVVIEGEPPSGGSRTDLGLQIDHIGHDMLPNIREYDRSQDVGPKDLPDHNRLAMREFEGLPRGLEEKSIALGSDNEDEKLSKGQHYIEISPLPGDLVTMERDHSATTEPLDVTKMQTFSVVPNQDKNHEIMKLLAVGSSEVSPRVIDPYVEEQIGQVAAMQKSKISEDDIKGEDLPNHSGDLSTFLHQEGKREKIAPRKGELFNPVSESEHCPPSRKDVVRSSFVTRHSRIPVLAQEIDSTFDSSSPVSAKEKLLQKKACQPDLVKLLVEKRQLRSLLGDLSSASDKLLEERLATVPAPFSEEEVFTPFSRLAADSHLSRSAEDNFLAPIISQSRKSKIPRPVSWVNTDQVNSSTPSQFLPRPPPGKPPMRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGTPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSFHHHSASTKAPPGKSKSASKLSR", "length": 1208, "header": "tr|E1BJC2-1|E1BJC2_BOVIN Computationally mapped isoform of Tau tubulin kinase 2 OS=Bos taurus OX=9913 GN=TTBK2 PE=3 SV=2 CANONICAL=A0AAA9SJA3-1" }, "locus": { "chromosome": "10", "start_pos": 38129334, "end_pos": 38039983, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008483.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008483.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008483.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008483.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1068, "start_aa": "Thr", "end_pos": 1068, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1068", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 653, "start_aa": "Thr", "end_pos": 653, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr653", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:541215", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541215", "resource": "KEGG Pathway" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RA74-1", "protein_name": "Tau tubulin kinase 2", "gene_name": "TTBK2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIWKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGTDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPAGVSPDKLPGSLGHPRPQEKDVWEELDANRNKIKLGVFKAATEEENSHGQANGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLALEPKPDTDKFLETCLEKMQKDSSAGKEALLPALLHKPCVPSVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFVAVNLSSCKQEVDSKEWVIVDKEQDLRDFRTNEALGHKTTGSPSDEEPEVLQVLEESPQDDKLRLGPWAENDHLKKETSGVILALSRECPATAASEQYTDRLELQAGAAGQFIAVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGQQPEKKDLHPMEPTVELFSPRENFSGLVVIEGEPPSGGSRTDLGLQMDHTGHDVLPNIRECDRPQDLGPKDLSDHDRPALGEFEGLPREKEGKSILLGSDNEDEKLSKKQHYIEIAPLPGDLVTVERDHTATAEPLDAIKTQTFSVVPNQDKNHEIMKLLAVGTSEISPHVTDPHVEGQIGQMAAMQKSKISKDDDLKSEDLPRHQGDLSTFLHQEGKREKMAPRNGELFHSVSESDHCPPSRKDVVRSSFVTRHSRIPVLAQEIDSAFESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQLKSFLGDLSSASDKLLEERLATVPAPFSEEQVFTPFSRLAVDSHLSRSAEDSFLTPIISQSRKSKIPRPVSWISTDQVNSSTSSQFLPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSSGLHHHSASTKAPPGKSKSASKLSR", "length": 1173 }, "evidence": [ { "id": "A0AAA9SJA3", "url": "https://omabrowser.org/oma/group/A0AAA9SJA3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0M2A2-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Ttbk2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPAGVSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCMEKMQKDSSAGKEPVLPALPHKPCVPAVPRTDHVWHYDEEYPPDASKPASANTPEQADGGGSHGFIAVNLSSCKQEVDSKEWVIVDKEQDLRDFRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNQHLKKESSGVILALSAECPATAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGPQPEKKDLQPLEPTVELFSPRENFSGLAVTEGELGSGGSRVDLGLQIDHIGHGMLPNMKDGDASQDLGPRDLPDSNRLVVKEFENLPGETEEKSILLGSDNEDEKLNKGQHCIEISLPGDLVTTERDQSATTEPLDVSKTQNFSVVPNQDKNHEIMKLLAVGTSEMSPQAIDPHAEGQIGQVATVQKHKLFKDDTKSESLPGQQGDLATFLHQEGKREKVAPRNGELYHCVSESEHGPPTRKDMLRSSLVTRHSRIPVLAQEIDSTFESSSAVSAKEKLLQKKAYQPEIVKLLVEKRQFKSFLGDLSSASEKLMEEKLAAAAVPFSEEEVFAPFSRLAVDPQLSRSVEDGFLSPIVSQSRKSKIPRPVSWVSTDQINSSASPQFLPRPPPGKPPVRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGPKGSGSLHHHSASSKTPPGKSKPASKLSR", "length": 1242 }, "evidence": [ { "id": "A0AAA9SJA3", "url": "https://omabrowser.org/oma/group/A0AAA9SJA3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FE66-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "ttbk2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGGLEQIDILSTGILVKERWKILKKIGGGGFGEIYEALDLMTRTSVALKAESAQQPKQVLKMEVAVLKKLQGKDHVCRFVGCGRNDRFNYVVMELQGRNLADLRRSMNRGTFTVSTTLRLGLQILEAIESIHSVGFLHRDIKPSNFAMGRFPSTCRTCYMLDFGLARQFTNSCQEVRPPRPVAGFRGTVRYASINAHKNKEMGRHDDLWSLFYMLVEFLVGQLPWRKIKDKEQVGKLKETYDHRLMLKHLPPQFTVFLDHISNLDYFTKPDYQLLRTVFENSMRTYNVVENDPYDWERISSDSPMTITATANTPQHHTRLTPAQMGIINNSLVPGDLLKENTEEVLQDEHLSDGDNPRPENLLGSPKLPLRNQEIDVWEDLDRNRNRISPAVLKIGTDDEHSNQGNQSPHAGPSIGSPVRVRSELVPSDRDTPLLRKLRNIHSFELEKRLTLEPKPNTERFVEACSGKQPPGTAQERCADGVPGMAISNGSPTERVWHYDEEFRSGSPKPASPGSPEQGDGAANSGFVHLSSGLQDVELRDWVMIEKVSDLQDFKESAGSSPGHVAKLTNSPSEECEEEPEVLQPMDESPDKESTPSAVQADIHMSHTVLSPQRMDRLELSVFPGSGGPPVTPTSPGEALAEGALTQLPTSPASQPEELVARTCSPLHLRSPSPHTLLTTLSDPLHQRAPPGMRRSQSADYQNHPSSYTSSCHGSLPLPSQPRAAHSPGRRKLPAIPATAANTKFPSVIRITRAQLQQLTAQRPSAMSSQCASDCGSLERRDTDNGNNGMHPQDNTADINSPQEQAAFQLTNLVNVEVDPLLNGNGHQKPSSPVPSLIPSPRTPPSPRSPILMNGCHTPPSDTRRNGNEQLQVLKDLNSDSLTLEHVNDPTLEEGKENAPATNGHSSPASTPKQDPSRRHSRIPVFEPSSILDPPHGSAKEKLLQRRVHHFPLSPSASPSLSSDRRAIMIAMQRDQISSASSERSQDDESLMGSRSDRHGDDALSLSSSSSPLLRKSKIPRPVTPTSSMETLTGQFMPRPPPGKPPSRSNVDGRLRRYRIRAGSTSDSDLLTCLAQLMHASSTHGSPQHSSSSPQHVSARHIFHHLHQRSSSASPRSSSSLQRSVSSSPSRHEHRGGCLGRSRSPPSFSGSPPQRRSHPHAQDGCCARQARSITIHTQRGKAAVRCSSKLSR", "length": 1193 }, "evidence": [ { "id": "A0AAA9SJA3", "url": "https://omabrowser.org/oma/group/A0AAA9SJA3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3UVR3-1", "protein_name": "Tau-tubulin kinase 2", "gene_name": "Ttbk2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCMEKMQKDSSAGKEPVPPALPHKPCVPVVTHTDHIWHYDDEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNHHLKKESSGVVLALSAECPATAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGPQPEKKDLQPLEPTVELYSPRENFSGLVVTEGELASGGSRVDLGLQIDHTGHDMLPNMRDGDTSQDLGPKDPPDHNRLAVKEFEHLPGETEERSLLLGSENEDERLSKGQHCIEVSSPGELVTAERAQLAATEPLHVSETQNCSVLPNQDKTHEIMKLLAVGTSEISPQAIDPHAEGQIGQMAAMQKNKLFKDDGIQSESLPRQQGDLSAFLHQEGKREKVVPRNGELYHCVSENEHGPPTRKDMLRSSFVTRHSRIPVLAQEIDSTFESSSAISAKEKLLQKKAYQPEIVKLLVEKRQFKSFLGDLSSASDKLIEEKLAAVPVPFSEEEVFAPFSRLAADSHLSRSVEDSFLSPIISQARKSKIPRPVSWVSTDQINGSASPQFLPRPPPGKPPVRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGPKGSGSLHHHSTSSKTPPGKSKPASKLSR", "length": 1243 }, "evidence": [ { "id": "A0AAA9SJA3", "url": "https://omabrowser.org/oma/group/A0AAA9SJA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6IQ55-1", "protein_name": "Tau-tubulin kinase 2", "gene_name": "TTBK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGEPPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEKSILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKNNEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFLHQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR", "length": 1244 }, "evidence": [ { "id": "A0AAA9SJA3", "url": "https://omabrowser.org/oma/group/A0AAA9SJA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "cerebellar granular layer development", "id": "GO:0021681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021681", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "negative regulation of microtubule depolymerization", "id": "GO:0007026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007026", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "cerebellar granule cell precursor tangential migration", "id": "GO:0021935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021935", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "negative regulation of protein localization to microtubule", "id": "GO:1902817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "ciliary base", "id": "GO:0097546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1065, "end_pos": 1067, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1116, "end_pos": 1118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" }, { "start_pos": 890, "end_pos": 892, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 284, "start_aa": "Trp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 653, 1068 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1065, "end_pos": 1067 }, { "start_pos": 1116, "end_pos": 1118 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 539, "end_pos": 541 }, { "start_pos": 710, "end_pos": 712 }, { "start_pos": 890, "end_pos": 892 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJA5-1", "uniprot_ac": "A0AAA9SJA5", "uniprot_id": "A0AAA9SJA5_BOVIN", "mass": { "chemical_mass": 9342.0, "monoisotopic_mass": 9342.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Family with sequence similarity 24 member A", "type": "recommended", "evidence": [ { "id": "A0AAA9SJA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJA5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR028122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR35860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35860:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35860:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFCIGGAILLAMLVLMAVVIGLYYKVANAMPKVPVCLALKNNPATVNPDKVSAALTTGSYPSLQCCDECNLYPGFDALPPCCCNVNEGL", "length": 89, "header": "tr|A0AAA9SJA5-1|A0AAA9SJA5_BOVIN Isoform 1 of Family with sequence similarity 24 member A OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SJA5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5/entry#A0AAA9SJA5-1", "sequence": { "sequence": "MFCIGGAILLAMLVLMAVVIGLYYKVANAMPKVPVCLALKNNPATVNPDKVSAALTTGSYPSLQCCDECNLYPGFDALPPCCCNVNEGL", "length": 89, "header": "tr|A0AAA9SJA5-1|A0AAA9SJA5_BOVIN Isoform 1 of Family with sequence similarity 24 member A OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SJA5-1" }, "locus": { "chromosome": "26", "start_pos": 42695554, "end_pos": 42694158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082665.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJC0-1", "uniprot_ac": "A0AAA9SJC0", "uniprot_id": "A0AAA9SJC0_BOVIN", "mass": { "chemical_mass": 121679.0, "monoisotopic_mass": 121679.0 }, "refseq": {}, "gene_names": [ { "name": "USP35", "type": "recommended", "evidence": [ { "id": "A0AAA9SJC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ] } ], "protein_names": [ { "name": "Ubiquitin specific peptidase 35", "type": "synonym", "evidence": [ { "id": "A0AAA9SJC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "USP35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0", "locus": { "chromosome": "29", "start_pos": 17795835, "end_pos": 17860064, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012944", "url": "https://www.ensembl.org/id/ENSBTAG00000012944" } ] } } ], "crossref": [ { "id": "A0AAA9SJC0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012944", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012944", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525702", "url": "https://www.ncbi.nlm.nih.gov/gene/525702", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049407", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049407", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525702", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525702", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YKMCGRS", "url": "https://omabrowser.org/oma/group/YKMCGRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BG52", "url": "https://www.orthodb.org/?gene=E1BG52", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24006:SF660", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24006:SF660", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG52", "url": "https://www.uniprot.org/uniprotkb/E1BG52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG52-1", "url": "https://www.uniprot.org/uniprotkb/E1BG52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTWGPESLVTMDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGTRLYVSGADELPRRVGCQLLHVAGRHHPEVFAEFFSARRVLRLLQGGAGPPSARALACVQLCLQLLPEGPGADEVFALLRREVLRTVCERPGPAVCAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPGPSATSVEKMFGGKIVTRICCLRCLNVSSREEAFTDLSLAFPPPERCRRHHHHHHHRRRRLGSVMLPAEDAGAQEPGSAGPRRQRKHCITGGVPPTILDMEGLGPHGLGGQSGQEEKVERGESTEEEEAAGEEEEEEEEEKVKAEVEEKVEEEKVKEEEKVKEKVEEEEERAAQEEKEKVEEEKEKVEEEKEKEMEEERAAQDKEEEVKKKVKEKVEEEEKVEEKEKEAQEEKEAAADGEEAAAGPGPGTLQSAAAASGDGSRSVLDLVNYFLSPERLTSENRYHCESCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVSVPLLLRLPLAGGRGQAYDLCSVVVHSGLSSESGHYYCYAREGAARPAPALGAAERPEPDNQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPEEGSEAEPGSPRTRAEPTLHKDLMEAISKDNILFLQEQEKEARSRAAYISALPASPHWRRGFDDDKDEDKGPPGGCGPAGGSGGDFNRLVF", "length": 1092, "header": "tr|A0AAA9SJC0-1|A0AAA9SJC0_BOVIN Isoform 1 of Ubiquitin specific peptidase 35 OS=Bos taurus OX=9913 GN=USP35 PE=4 SV=1 CANONICAL=A0AAA9SJC0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0/entry#A0AAA9SJC0-1", "sequence": { "sequence": "MGTWGPESLVTMDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGTRLYVSGADELPRRVGCQLLHVAGRHHPEVFAEFFSARRVLRLLQGGAGPPSARALACVQLCLQLLPEGPGADEVFALLRREVLRTVCERPGPAVCAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPGPSATSVEKMFGGKIVTRICCLRCLNVSSREEAFTDLSLAFPPPERCRRHHHHHHHRRRRLGSVMLPAEDAGAQEPGSAGPRRQRKHCITGGVPPTILDMEGLGPHGLGGQSGQEEKVERGESTEEEEAAGEEEEEEEEEKVKAEVEEKVEEEKVKEEEKVKEKVEEEEERAAQEEKEKVEEEKEKVEEEKEKEMEEERAAQDKEEEVKKKVKEKVEEEEKVEEKEKEAQEEKEAAADGEEAAAGPGPGTLQSAAAASGDGSRSVLDLVNYFLSPERLTSENRYHCESCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVSVPLLLRLPLAGGRGQAYDLCSVVVHSGLSSESGHYYCYAREGAARPAPALGAAERPEPDNQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPEEGSEAEPGSPRTRAEPTLHKDLMEAISKDNILFLQEQEKEARSRAAYISALPASPHWRRGFDDDKDEDKGPPGGCGPAGGSGGDFNRLVF", "length": 1092, "header": "tr|A0AAA9SJC0-1|A0AAA9SJC0_BOVIN Isoform 1 of Ubiquitin specific peptidase 35 OS=Bos taurus OX=9913 GN=USP35 PE=4 SV=1 CANONICAL=A0AAA9SJC0-1" }, "locus": { "chromosome": "29", "start_pos": 17853599, "end_pos": 17796839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115192.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115192.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086365.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086365.1" } ] } }, { "isoform_ac": "A0AAA9THL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0/entry#A0AAA9THL2-1", "sequence": { "sequence": "MDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGTRLYVSGADELPRRVGCQLLHVAGRHHPEVFAEFFSARRVLRLLQGGAGPPSARALACVQLCLQLLPEGPGADEVFALLRREVLRTVCERPGPAVCAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPGPSATSVEKMFGGKIVTRICCLRCLNVSSREEAFTDLSLAFPPPERCRRHHHHHHHRRRRLGSVMLPAEDAGAQEPGSAGPRRQRKHCITGGVPPTILDMEGLGPHGLGGQSGQEEKVEEEKEKVEEEKEKEMEEERAAQDKEEEVKKKVKEKVEEEEKVEEKEKEAQEEKEAAADGEEAAAGPGPGTLQSAAAASGDGSRSVLDLVNYFLSPERLTSENRYHCESCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVSVPLLLRLPLAGGRGQAYDLCSVVVHSGLSSESGHYYCYAREGAARPAPALGAAERPEPDNQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPEEGSEAEPGSPRTRAEPTLHKDLMEAISKDNILFLQEQEKEARSRAAYISALPASPHWRRGFDDDKDEDKGPPGGCGPAGGSGGDFNRLVF", "length": 1019, "header": "tr|A0AAA9THL2-1|A0AAA9THL2_BOVIN Computationally mapped isoform of Ubiquitin specific peptidase 35 OS=Bos taurus OX=9913 GN=USP35 PE=4 SV=1 CANONICAL=A0AAA9SJC0-1" }, "locus": { "chromosome": "29", "start_pos": 17853449, "end_pos": 17796839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116220.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116220.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097740.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097740.1" } ] } }, { "isoform_ac": "E1BG52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0/entry#E1BG52-1", "sequence": { "sequence": "MDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGTRLYVSGADELPRRVGCQLLHVAGRHHPEVFAEFFSARRVLRLLQGGAGPPSARALACVQLCLQLLPEGPGADEVFALLRREVLRTVCERPGPAVCAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPGPSATSVEKMFGGKIVTRICCLRCLNVSSREEAFTDLSLAFPPPERCRRHHHHHHHRRRRLGSVMLPAEDAGAQEPGSAGPRRQRKHCITGGVPPTILDMEGLGPHGLGGQSGQEEKVERGESTEEEEAAGEEEEEEEEEKVKAEVEEKVEEEKVKEEEKVKEKVEEEEERAAQEEKEKVEEEKEKVEEEKEKEMEEERAAQDKEEEVKKKVKEKVEEEEKVEEKEKEAQEEKEAAADGEEAAAGPGPGTLQSAAAASGDGSRSVLDLVNYFLSPERLTSENRYHCESCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVSVPLLLRLPLAGGRGQAYDLCSVVVHSGLSSESGHYYCYAREGAARPAPALGAAERPEPDNQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPEEGSEAEPGSPRTRAEPTLHKDLMEAISKDNILFLQEQEKEARSRAAYISALPASPHWRRGFDDDKDEDKGPPGGCGPAGGSGGDFNRLVF", "length": 1081, "header": "tr|E1BG52-1|A0AAA9SJC0_BOVIN Computationally mapped isoform of Ubiquitin specific peptidase 35 OS=Bos taurus OX=9913 GN=USP35 PE=4 SV=3 CANONICAL=A0AAA9SJC0-1" }, "locus": { "chromosome": "29", "start_pos": 17853449, "end_pos": 17796839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017198.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017198.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017198.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017198.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525702", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525702", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UDW5-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP35", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDKILEAVVMSSYPNNVKQGLVRRVIEASKQPMDSEQCWSMLELCTKLYLVGDTKYKREIGKEVLEVYGHYHPEEFEEFFNVRFLLSLLQEGYGPLGKRSHYVLDYIQLGLQFVLESPSANSIFSLLRIEVLRKVCERPSPKQCAKISKLLTQHPQCIPTGKHQVLFCQQLIRCIGQFQCVSEGEDDIMEFLEQVNKVSGLLQRIWRTQTSAILPSLKELFTIISSTEEQEVPSNALASVVQFVPLELMDGVIRNLTNDDSITDVQMMMAIGRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVTLSKIEKVFSKLLYPIVREGALSVLQYMLLSFQHSHEAFHLLLPHIPRLVASLKKEDSNSATSSLEQLAELIHCMFFRFSGFPDLYEPVLEAIKALPIPNEDRIKHLLGQNAWTSQKNELACFYPRLASKSETGKIGLINLGNTCYMNSVIQSLFMASDFRHSVLNLTEGNSQPLMTKLQWLFAFLEHSQRPAISPESFFSASWPPWFTPGAQQDCSEYLKYLLDRLHEEEKTGKRIYQKLKESSLMSQAMEHHSLNKTLIEKMFGGKMMTKIRCLKCLNISSREEAFTDLSLAFPPPDRPICRLGSTSVLPVEEIGPQFIEPPKTPSQPTGSPWVRRKPPVSGDPAAQPVLVETLGFREPRETAHPLSNNAVGVDTKDPHLAFGEQTCAPKDSRSVPDLINYFLSPERLTADNKYHCEKCASLQDAEKVAELTEGPHYLILTLLRFSFDPQTMKRRKILDNVSIPVVLKLPILVSSEETEDICWHGKDRSDLGSTFVSAVYDLCSVVVHSGISSESGHYYCYSRECTDTVPHAQPRDGTPKPASDKQLDFEIPWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRLGRPSSPLHEAVAEASHLHSEPSLNKDLMEAISKDNILYLQEQEKEARNRAAYISTLPKSPLWWRDFERDKDDDSSSGGCSPAGGGGGSGSFHGLVF", "length": 997 }, "evidence": [ { "id": "A0AAA9SJC0", "url": "https://omabrowser.org/oma/group/A0AAA9SJC0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M8S4-1", "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "Usp35", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGTDELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGARALACVQLGLQLLPDGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGAHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALCVLKYMLLTFQHSHEAFHLLLPHIPPMVAALVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHIPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSVLQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSLPSPQEELPSSNATSVERMFGGKIVTRICCLHCLNVSSREEAFTDLSLAFPPPERSRHRRLGSVMLPTEDVRAQELTLAPRAPGAQRQRKHCITGDAPRTGLDIEGVDTVGNGGQSGQEKVEREQAGKEKEVAEDREEEGPREEEKEEGEEKDKEKKEDEKEKEAEDGKEKEGDSLGPGTRKDAATPPREQACGPEGSRSVLDLVNYFLSPERLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVTIPLLLRLPLAGGQGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAPVLGSTERPEPENQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPQEAPEAEPGSPRVRAEPTLHKDLMEAISKDNVLYLQEQEKEARSRAAYISTLPAPPHWSRGFDEDKDEDEGSAGGCNPAGGNGDFHRLVF", "length": 1007 }, "evidence": [ { "id": "A0AAA9SJC0", "url": "https://omabrowser.org/oma/group/A0AAA9SJC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0QWN7-1", "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "Usp35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDKILEAVVTSSYPASVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGTEELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGARALACVQLGLQLLPDGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGAHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCTEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPAMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHIPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSVLQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGMRICQKLKQSSLPSPQEELPSSNATSVEKMFGGKIVTRICCLHCLNVSSREEAFTDLSLAFPPPERSRHRRLGSVMLPTEDVRVQELTLAPRAPGAQRQRKRCITGDAPRTGLDSEGVDTIGTGGRSGQEKVEREQAGKEKEVAEDREEEGTREEEKEEGEEKDKEKEKKEDEKEKEAENGKEKEGDSLGPGTHREAATPPREQTCGPEGSRSVLDLVNYFLSPERLTAENRYYCESCASLQDAEKVVELSQGPRYLILTLLRFSFDLRTMRRRKILDDVTIPLLLRLPLAGGQGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAPVLGSTERPEPENQWYLFNDTRVSYSSFESVSNVTSFFPKDTAYVLFYRQRPREDPAAEPGSPRVRAEPTLHKDLMEAISKDNVLYLQEQEKEARSRAAYISTLPAPPHWGRGFDEDKDEDEGSPGGCNPAGGNGDFHRLVF", "length": 1009 }, "evidence": [ { "id": "A0AAA9SJC0", "url": "https://omabrowser.org/oma/group/A0AAA9SJC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2H5-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 35", "gene_name": "USP35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDKILEAVVTSSYPVSVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGAEELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRALACVQLGLQLLPEGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCAEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQRKHCITEDTPPTSLYIEGLDSKEAGGQSSQEERIEREEEGKEERTEKEEVGEEEESTRGEGEREKEEEVEEEEEKVEKETEKEAEQEKEEDSLGAGTHPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPREGPEAELGSSRVRTEPTLHKDLMEAISKDNILYLQEQEKEARSRAAYISALPTSPHWGRGFDEDKDEDEGSPGGCNPAGGNGGDFHRLVF", "length": 1018 }, "evidence": [ { "id": "A0AAA9SJC0", "url": "https://omabrowser.org/oma/group/A0AAA9SJC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 596, "end_pos": 598, "annotation": "n_glycosylation_sequon" }, { "start_pos": 968, "end_pos": 970, "annotation": "n_glycosylation_sequon" }, { "start_pos": 982, "end_pos": 984, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC0" }, { "id": "PS50235", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50235" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "USP", "eco_id": "ECO_0000259", "start_pos": 452, "end_pos": 1000, "start_aa": "Ile", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 262, "end_pos": 264 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 596, "end_pos": 598 }, { "start_pos": 968, "end_pos": 970 }, { "start_pos": 982, "end_pos": 984 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJE1-1", "uniprot_ac": "A0AAA9SJE1", "uniprot_id": "A0AAA9SJE1_BOVIN", "mass": { "chemical_mass": 40831.0, "monoisotopic_mass": 40831.0 }, "refseq": { "ac": "XP_010806347", "name": "uncharacterized protein C8orf58 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806347" }, "gene_names": [ { "name": "C8H8orf58", "type": "recommended", "evidence": [ { "id": "A0AAA9SJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1" } ] }, { "name": "C8H8orf58", "type": "synonym", "evidence": [ { "id": "XP_010806347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806347" } ] } ], "protein_names": [ { "name": "Chromosome 8 C8orf58 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C8orf58 homolog", "type": "synonym", "evidence": [ { "id": "XP_010806347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806347" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C8H8orf58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1", "locus": { "chromosome": "8", "start_pos": 69906826, "end_pos": 69900189, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005466", "url": "https://www.ensembl.org/id/ENSBTAG00000005466" } ] } } ], "crossref": [ { "id": "A0AAA9SJE1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "101902190", "url": "https://www.ncbi.nlm.nih.gov/gene/101902190", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101902190", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902190", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR37336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37336:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37336:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15552", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15552", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010806347", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGRRRVFAVEPLGGQDGAGEDLAHGCVVPGVNSTYRQIPDVAPVCSSDSWKRQDQLRGPQGQVPLLKLGSQDSGVEMAVGDSSLATSPSFSQDSLNFEPLESAESLALGALEPPAHLSRLLASRKLEQVLKRSHQLSVPPTSLSQHCHSPKLSPKCEMPHSEARGPEATEAESDLEDGLEQAEVVEDLEPEACSGLPGQGLRYLEHLCAVLEQVANLQQLCLQLQTQRGPADPEEEEETTLAPSPLPSYAPGSEVRGPWEWLSQTEETGAKTASPPKVGAPSASPPRLSEALMEPAHTSSSQEHKGDRSHCNKVKVLLNRIRWGSPRPAELATSADGPVTHRIASRDLPEKPLGHPLQKTFMPSLVVKKKQDKNLSVH", "length": 379, "header": "tr|A0AAA9SJE1-1|A0AAA9SJE1_BOVIN Isoform 1 of Chromosome 8 C8orf58 homolog OS=Bos taurus OX=9913 GN=C8H8orf58 PE=4 SV=1 CANONICAL=A0AAA9SJE1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1/entry#A0AAA9SJE1-1", "sequence": { "sequence": "MLGRRRVFAVEPLGGQDGAGEDLAHGCVVPGVNSTYRQIPDVAPVCSSDSWKRQDQLRGPQGQVPLLKLGSQDSGVEMAVGDSSLATSPSFSQDSLNFEPLESAESLALGALEPPAHLSRLLASRKLEQVLKRSHQLSVPPTSLSQHCHSPKLSPKCEMPHSEARGPEATEAESDLEDGLEQAEVVEDLEPEACSGLPGQGLRYLEHLCAVLEQVANLQQLCLQLQTQRGPADPEEEEETTLAPSPLPSYAPGSEVRGPWEWLSQTEETGAKTASPPKVGAPSASPPRLSEALMEPAHTSSSQEHKGDRSHCNKVKVLLNRIRWGSPRPAELATSADGPVTHRIASRDLPEKPLGHPLQKTFMPSLVVKKKQDKNLSVH", "length": 379, "header": "tr|A0AAA9SJE1-1|A0AAA9SJE1_BOVIN Isoform 1 of Chromosome 8 C8orf58 homolog OS=Bos taurus OX=9913 GN=C8H8orf58 PE=4 SV=1 CANONICAL=A0AAA9SJE1-1" }, "locus": { "chromosome": "8", "start_pos": 69905822, "end_pos": 69900779, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110474.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110474.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085450.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101902190", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902190", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE1" }, { "id": "PF15552", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15552" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4657", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 378, "start_aa": "Met", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 }, { "start_pos": 375, "end_pos": 377 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJE2-1", "uniprot_ac": "A0AAA9SJE2", "uniprot_id": "A0AAA9SJE2_BOVIN", "mass": { "chemical_mass": 35289.0, "monoisotopic_mass": 35289.0 }, "refseq": { "ac": "XP_002683646", "name": "olfactory receptor 5H19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002683646" }, "gene_names": [ { "name": "OR5H33", "type": "recommended", "evidence": [ { "id": "A0AAA9SJE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2" } ] }, { "name": "OR5H33", "type": "synonym", "evidence": [ { "id": "XP_002683646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002683646" } ] } ], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 5H19", "type": "synonym", "evidence": [ { "id": "XP_002683646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002683646" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5H33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "783917", "url": "https://www.ncbi.nlm.nih.gov/gene/783917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783917", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783917", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002683646", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002683646", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METKNVTELTEFILTGLTHQPEWQIPLFLLFLMIYLITIVGNLGLIMLICNDPHLHIPMYLFLGNLAFVDTWLSSTVTPKMLLNFFTMSKMISLSECKIQFFSFAICVTTECFLLATMVFDRYVAICKPLLYPVIMTNRLCIWLLVLSFLGGIFHAIIHNAFLLRLTFCNSIIVNHFYCDIIPLFKISCTDPSINFLIVFIFAGSIQTFTISIVLVSYTLVLFTILKKKSLQGVRKAVSTCGAHLLSVSLYYGPLLFMYVLPGSAQENDQNMMDSLFYTVIIPFLNPIIYSLRNKKVIDSLTKMLKRNV", "length": 309, "header": "tr|A0AAA9SJE2-1|A0AAA9SJE2_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=OR5H33 PE=3 SV=1 CANONICAL=A0AAA9SJE2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2/entry#A0AAA9SJE2-1", "sequence": { "sequence": "METKNVTELTEFILTGLTHQPEWQIPLFLLFLMIYLITIVGNLGLIMLICNDPHLHIPMYLFLGNLAFVDTWLSSTVTPKMLLNFFTMSKMISLSECKIQFFSFAICVTTECFLLATMVFDRYVAICKPLLYPVIMTNRLCIWLLVLSFLGGIFHAIIHNAFLLRLTFCNSIIVNHFYCDIIPLFKISCTDPSINFLIVFIFAGSIQTFTISIVLVSYTLVLFTILKKKSLQGVRKAVSTCGAHLLSVSLYYGPLLFMYVLPGSAQENDQNMMDSLFYTVIIPFLNPIIYSLRNKKVIDSLTKMLKRNV", "length": 309, "header": "tr|A0AAA9SJE2-1|A0AAA9SJE2_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=OR5H33 PE=3 SV=1 CANONICAL=A0AAA9SJE2-1" }, "locus": { "chromosome": "1", "start_pos": 42548860, "end_pos": 42547934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132915.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132915.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084019.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084019.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783917", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJE9-1", "uniprot_ac": "A0AAA9SJE9", "uniprot_id": "A0AAA9SJE9_BOVIN", "mass": { "chemical_mass": 39343.0, "monoisotopic_mass": 39343.0 }, "refseq": {}, "gene_names": [ { "name": "RBM43", "type": "recommended", "evidence": [ { "id": "A0AAA9SJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9" } ] } ], "protein_names": [ { "name": "RNA binding motif protein 43", "type": "synonym", "evidence": [ { "id": "A0AAA9SJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9", "locus": { "chromosome": "2", "start_pos": 44869106, "end_pos": 44857595, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016217", "url": "https://www.ensembl.org/id/ENSBTAG00000016217" } ] } } ], "crossref": [ { "id": "A0AAA9SJE9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJE9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15225", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15225", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15225:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15225:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28453", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28453", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRTGASVLNVKESNASERTVVVADLPVDLNDQLVTTLVKIHFEDTDNGGGVVEDVTYPTRTKGVAYVTFKEKTVAENVVRKKKHSLAGMAGSAQLIVSHFSEKIFSSVKAVLDLSVFRSQIRLESLVMDLKREIPTLCFSPLEANGRISVQGTFLAIEKLKESLLLKASFLLENSRNRQSPRGSTRRSSHSLKPARSLTPETTKRGESLVLDTDTFLYLKKRTKFYESTLRRFHVLCQETVDGEITTLCIKNAQGGSQSNNEKKVKESIEKYSHILHFELRKETFILEGKEDREKENIKLACERLSLSYLQVLVNFYKTHIDVIGSPPDTYLFKKEVMELIRQKVR", "length": 347, "header": "tr|A0AAA9SJE9-1|A0AAA9SJE9_BOVIN Isoform 1 of RNA binding motif protein 43 OS=Bos taurus OX=9913 GN=RBM43 PE=4 SV=1 CANONICAL=A0AAA9SJE9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9/entry#A0AAA9SJE9-1", "sequence": { "sequence": "MRRTGASVLNVKESNASERTVVVADLPVDLNDQLVTTLVKIHFEDTDNGGGVVEDVTYPTRTKGVAYVTFKEKTVAENVVRKKKHSLAGMAGSAQLIVSHFSEKIFSSVKAVLDLSVFRSQIRLESLVMDLKREIPTLCFSPLEANGRISVQGTFLAIEKLKESLLLKASFLLENSRNRQSPRGSTRRSSHSLKPARSLTPETTKRGESLVLDTDTFLYLKKRTKFYESTLRRFHVLCQETVDGEITTLCIKNAQGGSQSNNEKKVKESIEKYSHILHFELRKETFILEGKEDREKENIKLACERLSLSYLQVLVNFYKTHIDVIGSPPDTYLFKKEVMELIRQKVR", "length": 347, "header": "tr|A0AAA9SJE9-1|A0AAA9SJE9_BOVIN Isoform 1 of RNA binding motif protein 43 OS=Bos taurus OX=9913 GN=RBM43 PE=4 SV=1 CANONICAL=A0AAA9SJE9-1" }, "locus": { "chromosome": "2", "start_pos": 44867484, "end_pos": 44857713, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113213.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113213.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083934.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083934.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE9" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 104, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJG5-1", "uniprot_ac": "A0AAA9SJG5", "uniprot_id": "A0AAA9SJG5_BOVIN", "mass": { "chemical_mass": 49988.0, "monoisotopic_mass": 49988.0 }, "refseq": { "ac": "XP_005225481", "name": "5-hydroxytryptamine receptor 7 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225481" }, "gene_names": [ { "name": "HTR7", "type": "recommended", "evidence": [ { "id": "A0AAA9SJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ] }, { "name": "HTR7", "type": "synonym", "evidence": [ { "id": "XP_005225481", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225481" } ] } ], "protein_names": [ { "name": "5-hydroxytryptamine receptor 7", "type": "recommended", "evidence": [ { "id": "A0AAA9SJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5/entry#names_and_taxonomy" } ] }, { "name": "5-HT-X", "type": "synonym", "evidence": [ { "id": "A0AAA9SJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5/entry#names_and_taxonomy" } ] }, { "name": "5-hydroxytryptamine receptor 7 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225481", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225481" } ] }, { "name": "Serotonin receptor 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.", "evidence": [ { "database": "UniProtKB", "id": "E1BD86", "url": "https://www.uniprot.org/uniprotkb/E1BD86#function" }, { "database": "UniProtKB", "id": "ARBA00045776", "url": "https://www.uniprot.org/uniprotkb/ARBA00045776#function" }, { "database": "UniProtKB", "id": "A0AAA9TIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP8#function" }, { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HTR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5", "locus": { "chromosome": "26", "start_pos": 12372324, "end_pos": 12475974, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008783", "url": "https://www.ensembl.org/id/ENSBTAG00000008783" } ] } } ], "crossref": [ { "id": "A0AAA9SJG5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008783", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008783", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15329", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15329", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538510", "url": "https://www.ncbi.nlm.nih.gov/gene/538510", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538510", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538510", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BD86", "url": "https://www.orthodb.org/?gene=E1BD86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248:SF199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248:SF199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390666", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390666", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9706019", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9706019", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225481", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225481", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD86", "url": "https://www.uniprot.org/uniprotkb/E1BD86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD86-1", "url": "https://www.uniprot.org/uniprotkb/E1BD86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDVNSSGRPDLYGHLRSFFLPEVGRGLPDLSPDGAGPVAGSWAPHLLHGVVEVTASPGPTRDTPRDNTSGCWEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDGKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRPEEPDSVISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTMCWLPFFLLSTARPFICGIACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPELVLQNSDYCRKKSHDS", "length": 448, "header": "tr|A0AAA9SJG5-1|A0AAA9SJG5_BOVIN Isoform 1 of 5-hydroxytryptamine receptor 7 OS=Bos taurus OX=9913 GN=HTR7 PE=3 SV=1 CANONICAL=A0AAA9SJG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5/entry#A0AAA9SJG5-1", "sequence": { "sequence": "MMDVNSSGRPDLYGHLRSFFLPEVGRGLPDLSPDGAGPVAGSWAPHLLHGVVEVTASPGPTRDTPRDNTSGCWEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDGKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRPEEPDSVISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTMCWLPFFLLSTARPFICGIACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPELVLQNSDYCRKKSHDS", "length": 448, "header": "tr|A0AAA9SJG5-1|A0AAA9SJG5_BOVIN Isoform 1 of 5-hydroxytryptamine receptor 7 OS=Bos taurus OX=9913 GN=HTR7 PE=3 SV=1 CANONICAL=A0AAA9SJG5-1" }, "locus": { "chromosome": "26", "start_pos": 12475775, "end_pos": 12381744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118536.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118536.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086420.1" } ] } }, { "isoform_ac": "A0AAA9TIP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5/entry#A0AAA9TIP8-1", "sequence": { "sequence": "MMDVNSSGRPDLYGHLRSFFLPEVGRGLPDLSPDGAGPVAGSWAPHLLHGVVEVTASPGPTRDTPRDNTSGCWEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDGKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRPEEPDSVISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTMCWLPFFLLSTARPFICGIACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPELVLETHSSSLDSHVRRHFQWDREAEAPNPLRPSSQARRCSLTKL", "length": 476, "header": "tr|A0AAA9TIP8-1|A0AAA9TIP8_BOVIN Computationally mapped isoform of 5-hydroxytryptamine receptor 7 OS=Bos taurus OX=9913 GN=HTR7 PE=3 SV=1 CANONICAL=A0AAA9SJG5-1" }, "locus": { "chromosome": "26", "start_pos": 12475775, "end_pos": 12381775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100232.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100232.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098335.1" } ] } }, { "isoform_ac": "E1BD86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5/entry#E1BD86-1", "sequence": { "sequence": "MMDVNSSGRPDLYGHLRSFFLPEVGRGLPDLSPDGAGPVAGSWAPHLLHGVVEVTASPGPTRDTPRDNTSGCWEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDGKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRPEEPDSVISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTMCWLPFFLLSTARPFICGIACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPELVLMKEAETSP", "length": 443, "header": "tr|E1BD86-1|E1BD86_BOVIN Computationally mapped isoform of 5-hydroxytryptamine receptor 7 OS=Bos taurus OX=9913 GN=HTR7 PE=3 SV=4 CANONICAL=A0AAA9SJG5-1" }, "locus": { "chromosome": "26", "start_pos": 12475775, "end_pos": 12387948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011575.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011575.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011575.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011575.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538510", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538510", "resource": "KEGG Pathway" }, { "id": "R-BTA-390666", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390666", "resource": "Reactome", "description": "Serotonin receptors" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-9706019", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9706019", "resource": "Reactome", "description": "RHOBTB3 ATPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "smooth muscle contraction", "id": "GO:0006939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006939", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "circadian rhythm", "id": "GO:0007623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "vasoconstriction", "id": "GO:0042310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "adenylate cyclase-activating serotonin receptor signaling pathway", "id": "GO:0007192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "id": "GO:0007187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007187", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled serotonin receptor activity", "id": "GO:0004993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" }, { "name": "neurotransmitter receptor activity", "id": "GO:0030594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 100, "end_pos": 387, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJP0-1", "uniprot_ac": "A0AAA9SJP0", "uniprot_id": "A0AAA9SJP0_BOVIN", "mass": { "chemical_mass": 72814.0, "monoisotopic_mass": 72814.0 }, "refseq": { "ac": "XP_005216928", "name": "rab proteins geranylgeranyltransferase component A 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216928" }, "gene_names": [ { "name": "CHML", "type": "recommended", "evidence": [ { "id": "A0AAA9SJP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ] }, { "name": "CHML", "type": "synonym", "evidence": [ { "id": "XP_005216928", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216928" } ] } ], "protein_names": [ { "name": "Rab proteins geranylgeranyltransferase component A", "type": "recommended", "evidence": [ { "id": "A0AAA9SJP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0/entry#names_and_taxonomy" } ] }, { "name": "rab proteins geranylgeranyltransferase component A 2", "type": "synonym", "evidence": [ { "id": "XP_005216928", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216928" } ] } ], "function": [ { "annotation": "Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0#function" }, { "database": "UniProtKB", "id": "PIRNR016550", "url": "https://www.uniprot.org/uniprotkb/PIRNR016550#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHML", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0", "locus": { "chromosome": "16", "start_pos": 35155562, "end_pos": 35138162, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061790", "url": "https://www.ensembl.org/id/ENSBTAG00000061790" } ] } } ], "crossref": [ { "id": "532324", "url": "https://www.ncbi.nlm.nih.gov/gene/532324", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532324", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532324", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMKFLTA", "url": "https://omabrowser.org/oma/group/LMKFLTA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11787", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11787", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11787:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11787:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005216928", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216928", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANSLPTEFDVIVMGTGLPESILAAACSRSGQRVLHLDSRSYYGGNWASFSFPGLLSWLKEHQQNSDTGEESPAAWQDMIHETEEAIPLCKKDETIQHAEVFCYASQGMDGNIEELGALQKNPSCVASSTLIKPLDSACLSEETHSSHITSYEVPTQDTPKNNEEITDTAETSVKEEYCGYDTYKHTVSDGTKDEIKPVLEDNSVPPKRKRIAYSQIVKEGRRFNIDLSSKLLYSQGLLIDLLIKSNVSRYAEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLDYEQHPEEYQAFTQCSFSEYLKTKNLTPSLQHFILHSIAMMSESSCTTVDGLKATKTFLQCLGRFGNTPFLFPLYGQGEIPQCFCRMCAVFGGIYCLRHKVQCLVVDRESGRCKAIIDHLGQRINAKYFIVEDSYLSEETCSSVQYKQISRAVLITDQSVLKTDSDQQISILIVPPVEPGAYAVRIIELCSSTMTCMKDTYLVHLTCSSSKTAREDLESVVKKLFTPYSETEVDNEELPKPGLLWALYFNMRDSSGVSRSSYNGLPPNVYVCTGPDSGLGSEHAVKQAETLFHEIFPSEEFCPPPPNPEDIFFDGDEKPSEPLGTNNIVMAKLESSEGSKNLESSGKHLQN", "length": 651, "header": "tr|A0AAA9SJP0-1|A0AAA9SJP0_BOVIN Isoform 1 of Rab proteins geranylgeranyltransferase component A OS=Bos taurus OX=9913 GN=CHML PE=3 SV=1 CANONICAL=A0AAA9SJP0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0/entry#A0AAA9SJP0-1", "sequence": { "sequence": "MANSLPTEFDVIVMGTGLPESILAAACSRSGQRVLHLDSRSYYGGNWASFSFPGLLSWLKEHQQNSDTGEESPAAWQDMIHETEEAIPLCKKDETIQHAEVFCYASQGMDGNIEELGALQKNPSCVASSTLIKPLDSACLSEETHSSHITSYEVPTQDTPKNNEEITDTAETSVKEEYCGYDTYKHTVSDGTKDEIKPVLEDNSVPPKRKRIAYSQIVKEGRRFNIDLSSKLLYSQGLLIDLLIKSNVSRYAEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLDYEQHPEEYQAFTQCSFSEYLKTKNLTPSLQHFILHSIAMMSESSCTTVDGLKATKTFLQCLGRFGNTPFLFPLYGQGEIPQCFCRMCAVFGGIYCLRHKVQCLVVDRESGRCKAIIDHLGQRINAKYFIVEDSYLSEETCSSVQYKQISRAVLITDQSVLKTDSDQQISILIVPPVEPGAYAVRIIELCSSTMTCMKDTYLVHLTCSSSKTAREDLESVVKKLFTPYSETEVDNEELPKPGLLWALYFNMRDSSGVSRSSYNGLPPNVYVCTGPDSGLGSEHAVKQAETLFHEIFPSEEFCPPPPNPEDIFFDGDEKPSEPLGTNNIVMAKLESSEGSKNLESSGKHLQN", "length": 651, "header": "tr|A0AAA9SJP0-1|A0AAA9SJP0_BOVIN Isoform 1 of Rab proteins geranylgeranyltransferase component A OS=Bos taurus OX=9913 GN=CHML PE=3 SV=1 CANONICAL=A0AAA9SJP0-1" }, "locus": { "chromosome": "16", "start_pos": 35145205, "end_pos": 35143253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118083.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118083.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085552.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085552.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532324", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532324", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AAJ7-1", "protein_name": "Rab proteins geranylgeranyltransferase component A", "gene_name": "Chml", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYGGNWASFSFTGLLSWLKDYQQNHDSEGDVTGTWQDLIDETEEAIALCKKDETIQHTEVFCYASQDVEDSMQETDPLQKSPSPEASATPADSLDTASLPKERHSEDCTSYEAPSRRTEGSDGAVSLSSADAQDSLEKEKFCGDETGMHTVSDGEEGEHKLAAEDNVGQPKRNTITYSQMVKESRTFNIDLVSKLLYSQGSLIDLLIKSNVSRYAEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLDYEQHSDEYQDFKQCSFSDYLKTKKLTPNLQHFILHSIAMSSDSSCTTLDGLQATKNFLRCLGRFGNTPFIFPLYGQGEIPQCFCRMCAVFGGVYCLRHKVQCLVVDRDSGRCKGIIDGFGQRISANYFIVEDSYLSKEMCSNIQYKQISRAVLITDQSILKTDSDQQISILVVPPLEPGTASVRVMELCSSTMTCMKDSYLVHLTCFSSKTAREDLEPVVKQLFIPFAEAEADKEELRKPRLLWALYFNMRDSSGVSRSSYCSLPSNVYICSGPDCGLGNEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFEAEG", "length": 621 }, "evidence": [ { "id": "A0AAA9SJP0", "url": "https://omabrowser.org/oma/group/A0AAA9SJP0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H6M4-1", "protein_name": "Rab proteins geranylgeranyltransferase component A", "gene_name": "Chml", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYGGNWASFSFTGLLSWLKDYEQNHDSEEDMTASWQDLIHETEDAIALCKKDETIENTEVFCYASQDDGDSTQENNALQRSPSPKASATLADSLDSAGLPKEGYTVYFSSHEAPSRHTERSDTEPSPSLTDAENSLDQEKDGGIQTVSDGDKDEDKPDIEDNSKQPKRNRITYPQMIKESRRFNIDLVSKLLYSQGSLIDLLIKSNVSRYAEFKNVTRILAFRDGKVEQVPCCRADVFSSKALTVVEKRMLMKFLTFCLDYEQHSDEYQDFKQCPFSEYLKTKKLTPNLQHFILHSIAMTSEPSCTTLDGLKATKTFLQCLGRFGNTPFIFPLYGQGEIPQCFCRMCAVFGGIYCLRHKVQCLVVDKDSGRCKGVIDHFGQRISANYFIVEDSYLSKETCSNVQYKQISRAVLITDQSILKTDSDHQISILVVPPLEPGSSSIRVMELCSSTMTCMKDSYLVHLTCVSSKTAREDLEPVVKQLFIPFAEAETDEEELRKPRLLWALYFNMRDSSGVSRSSYHGLPSNVYICSGPDCGLGNEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFEGEG", "length": 617 }, "evidence": [ { "id": "A0AAA9SJP0", "url": "https://omabrowser.org/oma/group/A0AAA9SJP0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P26374-1", "protein_name": "Rab proteins geranylgeranyltransferase component A 2", "gene_name": "CHML", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADNLPTEFDVVIIGTGLPESILAAACSRSGQRVLHIDSRSYYGGNWASFSFSGLLSWLKEYQQNNDIGEESTVVWQDLIHETEEAITLRKKDETIQHTEAFCYASQDMEDNVEEIGALQKNPSLGVSNTFTEVLDSALPEESQLSYFNSDEMPAKHTQKSDTEISLEVTDVEESVEKEKYCGDKTCMHTVSDKDGDKDESKSTVEDKADEPIRNRITYSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSRYVEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLEYEQHPDEYQAFRQCSFSEYLKTKKLTPNLQHFVLHSIAMTSESSCTTIDGLNATKNFLQCLGRFGNTPFLFPLYGQGEIPQGFCRMCAVFGGIYCLRHKVQCFVVDKESGRCKAIIDHFGQRINAKYFIVEDSYLSEETCSNVQYKQISRAVLITDQSILKTDLDQQTSILIVPPAEPGACAVRVTELCSSTMTCMKDTYLVHLTCSSSKTAREDLESVVKKLFTPYTETEINEEELTKPRLLWALYFNMRDSSGISRSSYNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEEFCPPPPNPEDIIFDGDDKQPEAPGTNNVVMAKLESSEESKNLESPEKHLQN", "length": 656 }, "evidence": [ { "id": "A0AAA9SJP0", "url": "https://omabrowser.org/oma/group/A0AAA9SJP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZD5-1", "protein_name": "Rab proteins geranylgeranyltransferase component A 2", "gene_name": "Chml", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYGGNWASFSFTGLQSWLKDYQQNHDSEEGVTATWQDLIHETEEAISLRKKDETIQHTEVFCYASQDVEDSVQDTETLQRSSPLEASATPADSLDSASLPKERQSAYSTSYEVPSRHTEESDRELSLPSANVEDSLEKEKYCGDKTDMHTVSGEDKGEHKLVVQDSIEQPKRNRITYSQMVKESRRFNIDLVSKPLYSQGSLIDLLIKSNVSRYAEFKNVTRILAFWEGKVEQVPCSRADVFNSKELSMVEKRMLMKFLTFCLDYEQHSDEYQDFKQCSFSDYLKTKKLTPNLQHFILHSIAMTSESSCTTLDGLQATKNFLQCLGRFGNTPFIFPLYGHGEIPQCFCRMCAVFGGVYCLRHKVQCLVVDKDSGRCKGIIDAFGQRISANYFIVEDSYLPKETCSNVQYKQISRAVLITDQSILKTDSDQQISILVVPPLEPGTTSVRVMELCSSTMTCMKDSYLVHLTCSSSKTAREDLEPVVKQLFIPEAEAEAGKDELRKPRLLWALYFNMRDSSGVSRSSYCGLPSNVYICSGPDWGLGSEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFEAEG", "length": 621 }, "evidence": [ { "id": "A0AAA9SJP0", "url": "https://omabrowser.org/oma/group/A0AAA9SJP0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V8W3-1", "protein_name": "Rab proteins geranylgeranyltransferase component A", "gene_name": "Rep", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLDDLPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFSMDALCARLDQEVEPHSALRNARYTWHSMEKESETDAQSWNRDSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFRAVDHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRGRTFLEYLQAQRVTEKISSCVMQAIAMCGPSTSFEEGMQRTQRFLGSLGRYGNTPFLFPMYGCGELPQCFCRLCAVYGGIYCLKRAVDDIALDSNSNEFLLSSAGKTLRAKNVVSAPGYTPVSKGIELKPHISRGLFISSSPLGNEELNKGGGGVNLLRLLDNEGGREAFLIQLSHYTGACPEGLYIFHLTTPALSEDPASDLAIFTSQLFDQSDAQIIFSSYFTIAAQSSKSPAAEHIYYTDPPTYELDYDAAIANARDIFGKMFPDADFLPRAPDPEEIVVDGEDPSALNEHTLPEDLRAQLHDMQQATQEMDIQE", "length": 511 }, "evidence": [ { "id": "A0AAA9SJP0", "url": "https://omabrowser.org/oma/group/A0AAA9SJP0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" }, { "name": "GDP-dissociation inhibitor activity", "id": "GO:0005092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005092", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" }, { "name": "Rab-protein geranylgeranyltransferase complex", "id": "GO:0005968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP0" }, { "id": "PF22603", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22603" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RAE1/2", "eco_id": "ECO_0000259", "start_pos": 449, "end_pos": 577, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 247, "end_pos": 249 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 325, "end_pos": 327 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJU0-1", "uniprot_ac": "A0AAA9SJU0", "uniprot_id": "A0AAA9SJU0_BOVIN", "mass": { "chemical_mass": 39750.0, "monoisotopic_mass": 39750.0 }, "refseq": {}, "gene_names": [ { "name": "OPN5", "type": "recommended", "evidence": [ { "id": "A0AAA9SJU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ] } ], "protein_names": [ { "name": "Opsin-5", "type": "recommended", "evidence": [ { "id": "A0AAA9SJU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 136", "type": "synonym", "evidence": [ { "id": "A0AAA9SJU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor PGR12", "type": "synonym", "evidence": [ { "id": "A0AAA9SJU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0/entry#names_and_taxonomy" } ] }, { "name": "Neuropsin", "type": "synonym", "evidence": [ { "id": "A0AAA9SJU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OPN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0", "locus": { "chromosome": "23", "start_pos": 20849970, "end_pos": 20807288, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016499", "url": "https://www.ensembl.org/id/ENSBTAG00000016499" } ] } } ], "crossref": [ { "id": "A0AAA9SJU0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016499", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016499", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15074", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15074", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541280", "url": "https://www.ncbi.nlm.nih.gov/gene/541280", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541280", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541280", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MENTTWP", "url": "https://omabrowser.org/oma/group/MENTTWP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BNN4", "url": "https://www.orthodb.org/?gene=E1BNN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-419771", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-419771", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNN4", "url": "https://www.uniprot.org/uniprotkb/E1BNN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BNN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALNHTAPPPDERRPPYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTVNLAICDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGIWLKRKHAYICLAVIWAYAAFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFRLHTVTTVRKSSAVLEIHQESEE", "length": 355, "header": "tr|A0AAA9SJU0-1|A0AAA9SJU0_BOVIN Isoform 1 of Opsin-5 OS=Bos taurus OX=9913 GN=OPN5 PE=3 SV=1 CANONICAL=A0AAA9SJU0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0/entry#A0AAA9SJU0-1", "sequence": { "sequence": "MALNHTAPPPDERRPPYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTVNLAICDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGIWLKRKHAYICLAVIWAYAAFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFRLHTVTTVRKSSAVLEIHQESEE", "length": 355, "header": "tr|A0AAA9SJU0-1|A0AAA9SJU0_BOVIN Isoform 1 of Opsin-5 OS=Bos taurus OX=9913 GN=OPN5 PE=3 SV=1 CANONICAL=A0AAA9SJU0-1" }, "locus": { "chromosome": "23", "start_pos": 20849970, "end_pos": 20807288, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133715.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133715.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084090.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084090.1" } ] } }, { "isoform_ac": "E1BNN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0/entry#E1BNN4-1", "sequence": { "sequence": "MALNHTAPPPDERRPPYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTVNLAICDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGIWLKRKHAYICLAVIWAYAAFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFRLHTVTTVRKSSAVLEIHQEV", "length": 353, "header": "tr|E1BNN4-1|E1BNN4_BOVIN Computationally mapped isoform of Opsin-5 OS=Bos taurus OX=9913 GN=OPN5 PE=3 SV=3 CANONICAL=A0AAA9SJU0-1" }, "locus": { "chromosome": "23", "start_pos": 20839671, "end_pos": 20807288, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021933.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021933.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021933.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021933.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541280", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541280", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-419771", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-419771", "resource": "Reactome", "description": "Opsins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R7I1-1", "protein_name": "Opsin-5", "gene_name": "OPN5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALNHTAPPPDERRPHYLREGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTVNLAICDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAVIWAYAAFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLVAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFRLHAVTTVRKSSAVLEIHQEV", "length": 353 }, "evidence": [ { "id": "A0AAA9SJU0", "url": "https://omabrowser.org/oma/group/A0AAA9SJU0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NEY2-1", "protein_name": "Opsin-5", "gene_name": "OPN5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGMASDCNSSSQEEYLPHYMQQEDPFASKLSREADIIAGFYLTVIGILSTLGNGYVIFMSSKRKKKLRPAEIMTVNLAVCDLGISVVGKPFSIISFFSHRWIFGWMGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLAYGTWLKRHHAFICLALIWAYATFWATVPFAGVGSYAPEPFGTSCTLDWWLAQASVAGQAFVLSILFFCLLFPTAVIVFSYVKIILKVKSSTKEVAHYDTRIQNSHILEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGQPDSVPIQFSVVPTLLAKSAAMYNPIIYQVIDCKFACCRSGGPKTLQKKSSLKESRMYTISSHRDSAALSGTQLEV", "length": 357 }, "evidence": [ { "id": "A0AAA9SJU0", "url": "https://omabrowser.org/oma/group/A0AAA9SJU0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6U736-1", "protein_name": "Opsin-5", "gene_name": "OPN5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE", "length": 354 }, "evidence": [ { "id": "A0AAA9SJU0", "url": "https://omabrowser.org/oma/group/A0AAA9SJU0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6VZZ7-1", "protein_name": "Opsin-5", "gene_name": "Opn5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALNHTALPQDERLPHYLRDEDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWFGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASGGGQVFILSILFFCLLLPTAVIVFSYAKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYRFACCQAGGLRGTKKKSLEDFRLHTVTAVRKSSAVLEIHPESSSRFTSAHVMDGESHSNDGDCGKK", "length": 377 }, "evidence": [ { "id": "A0AAA9SJU0", "url": "https://omabrowser.org/oma/group/A0AAA9SJU0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "hyaloid vascular plexus regression", "id": "GO:1990384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990384", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "positive regulation of wound healing", "id": "GO:0090303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "entrainment of circadian clock by photoperiod", "id": "GO:0043153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043153", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "cellular response to UV-A", "id": "GO:0071492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071492", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "phototransduction, UV", "id": "GO:0007604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "phototransduction", "id": "GO:0007602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "cellular response to light stimulus", "id": "GO:0071482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071482", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "11-cis retinal binding", "id": "GO:0005502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005502", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" }, { "name": "G protein-coupled photoreceptor activity", "id": "GO:0008020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 306, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJU1-1", "uniprot_ac": "A0AAA9SJU1", "uniprot_id": "A0AAA9SJU1_BOVIN", "mass": { "chemical_mass": 11516.0, "monoisotopic_mass": 11516.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "GAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJU1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJU1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14047", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14047", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14047:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14047:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGQVASKLGPTNQDCSQVDEPVVDQQPSVEQPQQEEPPAEIQDITPRKEEVHGEDPVNHSGLEADLQQLAEAKTGGEGGDGPDVREEFASNIEPVEMPEAGEGQPFA", "length": 108, "header": "tr|A0AAA9SJU1-1|A0AAA9SJU1_BOVIN Isoform 1 of GAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SJU1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1/entry#A0AAA9SJU1-1", "sequence": { "sequence": "MSGQVASKLGPTNQDCSQVDEPVVDQQPSVEQPQQEEPPAEIQDITPRKEEVHGEDPVNHSGLEADLQQLAEAKTGGEGGDGPDVREEFASNIEPVEMPEAGEGQPFA", "length": 108, "header": "tr|A0AAA9SJU1-1|A0AAA9SJU1_BOVIN Isoform 1 of GAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SJU1-1" }, "locus": { "chromosome": "2", "start_pos": 126680321, "end_pos": 126679965, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121100.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121100.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084185.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU1" }, { "id": "SM01379", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01379" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAGE", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 108, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJV2-1", "uniprot_ac": "A0AAA9SJV2", "uniprot_id": "A0AAA9SJV2_BOVIN", "mass": { "chemical_mass": 64796.0, "monoisotopic_mass": 64796.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Cationic amino acid transporter C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJV2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTMLGQCLRQFGQKLVHRKPQFREEPESPETPPLNTLDLVVIGLDNMLGAGIYILIGGVAKYVAGPAIILFLLVAGLTTLLSGLCYVELATGVKVPVSGYYVSYVTMGQLYAFITGWNLLLYLIIATACIARAWSSTFDSLIGNHISEALGGTFSLQMPYFLASFPDFLALGLVLLLTGLLALRVYDSTVINKVFTGLNILVLSFIILSGFIKGDLHNWKLIEQDYTLAAAGSGDADSLGLLGSGGFVPFGFDGILQGAATCFYAFVGFAHIVNAGRKARNPQWSIPLAVMISFFICFLVCFGVSAALTLMVPYYLIQLESPLPQAFVYVGWESAKYVVAVGTLCILLYSLLSIMFIMAQLTYAMAKDGLLFRGLAWIPAPTNARTDAPTDAPVMALLFDFTDLVDLMSLRSLLAYSLVTFSVLVLRYQPAQNGSKKEKTEEETKVEPEVEGGPLESEPEAGTSNILKSLWFPPSTNPTRKSGQIVYGCASLVVLLLTILSLILYHGVTVIIWRQPQSPFPLEPTFRVPALPAVFLVSTLVNVYLMIQMTTQTWAQFGIWMAIGKWLSGIKSTASLCLFPVKTHKLSCGRKHR", "length": 594, "header": "tr|A0AAA9SJV2-1|A0AAA9SJV2_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SJV2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2/entry#A0AAA9SJV2-1", "sequence": { "sequence": "MSTMLGQCLRQFGQKLVHRKPQFREEPESPETPPLNTLDLVVIGLDNMLGAGIYILIGGVAKYVAGPAIILFLLVAGLTTLLSGLCYVELATGVKVPVSGYYVSYVTMGQLYAFITGWNLLLYLIIATACIARAWSSTFDSLIGNHISEALGGTFSLQMPYFLASFPDFLALGLVLLLTGLLALRVYDSTVINKVFTGLNILVLSFIILSGFIKGDLHNWKLIEQDYTLAAAGSGDADSLGLLGSGGFVPFGFDGILQGAATCFYAFVGFAHIVNAGRKARNPQWSIPLAVMISFFICFLVCFGVSAALTLMVPYYLIQLESPLPQAFVYVGWESAKYVVAVGTLCILLYSLLSIMFIMAQLTYAMAKDGLLFRGLAWIPAPTNARTDAPTDAPVMALLFDFTDLVDLMSLRSLLAYSLVTFSVLVLRYQPAQNGSKKEKTEEETKVEPEVEGGPLESEPEAGTSNILKSLWFPPSTNPTRKSGQIVYGCASLVVLLLTILSLILYHGVTVIIWRQPQSPFPLEPTFRVPALPAVFLVSTLVNVYLMIQMTTQTWAQFGIWMAIGKWLSGIKSTASLCLFPVKTHKLSCGRKHR", "length": 594, "header": "tr|A0AAA9SJV2-1|A0AAA9SJV2_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SJV2-1" }, "locus": { "chromosome": "18", "start_pos": 60814077, "end_pos": 60808051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117854.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117854.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084195.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084195.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 434, "end_pos": 436, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV2" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 527, "end_pos": 565, "start_aa": "Phe", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 434, "end_pos": 436 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJV5-1", "uniprot_ac": "A0AAA9SJV5", "uniprot_id": "A0AAA9SJV5_BOVIN", "mass": { "chemical_mass": 34490.0, "monoisotopic_mass": 34490.0 }, "refseq": {}, "gene_names": [ { "name": "GINS2", "type": "recommended", "evidence": [ { "id": "A0AAA9SJV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" } ] } ], "protein_names": [ { "name": "GINS complex subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SJV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.", "evidence": [ { "database": "UniProtKB", "id": "E1BC42", "url": "https://www.uniprot.org/uniprotkb/E1BC42#function" }, { "database": "UniProtKB", "id": "ARBA00045258", "url": "https://www.uniprot.org/uniprotkb/ARBA00045258#function" }, { "database": "UniProtKB", "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GINS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5", "locus": { "chromosome": "18", "start_pos": 11648397, "end_pos": 11685193, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044006", "url": "https://www.ensembl.org/id/ENSBTAG00000044006" } ] } } ], "crossref": [ { "id": "A0AAA9SJV5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044006", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044006", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11712", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11712", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21694", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21694", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BC42", "url": "https://www.orthodb.org/?gene=E1BC42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12772", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12772", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12772:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12772:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-176974", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176974", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC42", "url": "https://www.uniprot.org/uniprotkb/E1BC42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC42-1", "url": "https://www.uniprot.org/uniprotkb/E1BC42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIGWHHRLDGHEFEQAGGDGDGQGGLARCSPRGCKESDTTERMNNSRPRSPPSPILTRGVGRQAPGAREGPPRAVLGAAPSSYRPARAPSGQGAGSARWRESGRHSGVFSETEGPEAAAASPGSAGGDAMDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVQVPLWLAVNLKQRQKCRLLPPEWMDVEKLEKIRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLIKDVWDTRIAKFRVSADSFVRQQEAHAKLDNLTLMEINTSGAFLTQALNHMYKLRTNLQPSDSAQSQDF", "length": 314, "header": "tr|A0AAA9SJV5-1|A0AAA9SJV5_BOVIN Isoform 1 of GINS complex subunit 2 OS=Bos taurus OX=9913 GN=GINS2 PE=3 SV=1 CANONICAL=A0AAA9SJV5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5/entry#A0AAA9SJV5-1", "sequence": { "sequence": "MIGWHHRLDGHEFEQAGGDGDGQGGLARCSPRGCKESDTTERMNNSRPRSPPSPILTRGVGRQAPGAREGPPRAVLGAAPSSYRPARAPSGQGAGSARWRESGRHSGVFSETEGPEAAAASPGSAGGDAMDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVQVPLWLAVNLKQRQKCRLLPPEWMDVEKLEKIRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLIKDVWDTRIAKFRVSADSFVRQQEAHAKLDNLTLMEINTSGAFLTQALNHMYKLRTNLQPSDSAQSQDF", "length": 314, "header": "tr|A0AAA9SJV5-1|A0AAA9SJV5_BOVIN Isoform 1 of GINS complex subunit 2 OS=Bos taurus OX=9913 GN=GINS2 PE=3 SV=1 CANONICAL=A0AAA9SJV5-1" }, "locus": { "chromosome": "18", "start_pos": 11684994, "end_pos": 11649401, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089556.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089556.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086583.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086583.1" } ] } }, { "isoform_ac": "E1BC42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5/entry#E1BC42-1", "sequence": { "sequence": "MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVQVPLWLAVNLKQRQKCRLLPPEWMDVEKLEKIRDHERKEETFTPMPSPYYMELTKLLLNQEGPGLPSACDPELDGKAPGQAPCRLLPQPECASVEKAAWASPALWSLSRLAVLLVAFTLHSLAPLFLVSQLCRPSSLSRVWGHAGLSHFHTASDNIPKADEIRTLIKDVWDTRIAKFRVSADSFVRQQEAHAKLDNLTLMEINTSGAFLTQALNHMYKLRTNLQPSDSAQSQDF", "length": 276, "header": "tr|E1BC42-1|E1BC42_BOVIN Computationally mapped isoform of DNA replication complex GINS protein PSF2 OS=Bos taurus OX=9913 GN=GINS2 PE=3 SV=2 CANONICAL=A0AAA9SJV5-1" }, "locus": { "chromosome": "18", "start_pos": 11684437, "end_pos": 11649401, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061540.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061540.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053781.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053781.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-176974", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176974", "resource": "Reactome", "description": "Unwinding of DNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" } ], "pmid": "" }, { "name": "double-strand break repair via break-induced replication", "id": "GO:0000727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "GINS complex", "id": "GO:0000811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000811", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" } ], "pmid": "" }, { "name": "CMG complex", "id": "GO:0071162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071162", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" }, { "id": "PF25005", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25005" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA replication complex GINS protein PSF2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 189, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SJV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJV5" }, { "id": "PF05916", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GINS subunit", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 298, "start_aa": "Trp", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJW2-1", "uniprot_ac": "A0AAA9SJW2", "uniprot_id": "A0AAA9SJW2_BOVIN", "mass": { "chemical_mass": 49942.0, "monoisotopic_mass": 49942.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Elongation factor 1-alpha", "type": "recommended", "evidence": [ { "id": "A0AAA9SJW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2#function" }, { "database": "UniProtKB", "id": "RU000325", "url": "https://www.uniprot.org/uniprotkb/RU000325#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJW2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01883", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01883", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03693", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03693", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKEKTHMNIVIGHVDSGKSTPTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCALLIVAAGVGEFEASICKNEQTHEHAHLAYTLGVQQLILGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDDMLEPSANMPWFKGRKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLSLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRHGNVAGDSKNDPPMEAAGFTAQVIVLNHPGQISAGHAPVLDCHTAHIACKFAELKKIDHRSGKKLEDGPKFLKSGDTAIVDMVPGKPMCVESISDYPPLGHFAVCDMRQTVAVGVIKAVDKKEAGAGKVTKSAQKAQKAK", "length": 460, "header": "tr|A0AAA9SJW2-1|A0AAA9SJW2_BOVIN Isoform 1 of Elongation factor 1-alpha OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SJW2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2/entry#A0AAA9SJW2-1", "sequence": { "sequence": "MGKEKTHMNIVIGHVDSGKSTPTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCALLIVAAGVGEFEASICKNEQTHEHAHLAYTLGVQQLILGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDDMLEPSANMPWFKGRKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLSLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRHGNVAGDSKNDPPMEAAGFTAQVIVLNHPGQISAGHAPVLDCHTAHIACKFAELKKIDHRSGKKLEDGPKFLKSGDTAIVDMVPGKPMCVESISDYPPLGHFAVCDMRQTVAVGVIKAVDKKEAGAGKVTKSAQKAQKAK", "length": 460, "header": "tr|A0AAA9SJW2-1|A0AAA9SJW2_BOVIN Isoform 1 of Elongation factor 1-alpha OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SJW2-1" }, "locus": { "chromosome": "7", "start_pos": 39111577, "end_pos": 39110198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125330.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125330.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084207.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084207.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJW2" }, { "id": "PS51722", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tr-type G", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 241, "start_aa": "Glu", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 221, "end_pos": 223 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 313, "end_pos": 315 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJY1-1", "uniprot_ac": "A0AAA9SJY1", "uniprot_id": "A0AAA9SJY1_BOVIN", "mass": { "chemical_mass": 17485.0, "monoisotopic_mass": 17485.0 }, "refseq": { "ac": "XP_002697394", "name": "mitochondrial coiled-coil domain protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697394" }, "gene_names": [ { "name": "MCCD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SJY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1" } ] }, { "name": "MCCD1", "type": "synonym", "evidence": [ { "id": "XP_002697394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697394" } ] } ], "protein_names": [ { "name": "Mitochondrial coiled-coil domain 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SJY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial coiled-coil domain protein 1", "type": "synonym", "evidence": [ { "id": "XP_002697394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697394" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCCD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1", "locus": { "chromosome": "23", "start_pos": 27758180, "end_pos": 27760531, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069112", "url": "https://www.ensembl.org/id/ENSBTAG00000069112" } ] } } ], "crossref": [ { "id": "A0AAA9SJY1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "617505", "url": "https://www.ncbi.nlm.nih.gov/gene/617505", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617505", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617505", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR37877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37877:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37877:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697394", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697394", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPLAWLSQRCRHLLLPSWAPILQGSWRCCSQGPRSTAETSSTRNRKMSPSRERQPRPTAELAQAEELLEQQLELYQALVEGQEGAWEAQALVLKTQKLKEQMRRQREPGRSHLSFPSVAPSPSSPENCTPPSDQQHPSLSQALRKQKKLPQKG", "length": 155, "header": "tr|A0AAA9SJY1-1|A0AAA9SJY1_BOVIN Isoform 1 of Mitochondrial coiled-coil domain 1 OS=Bos taurus OX=9913 GN=MCCD1 PE=4 SV=1 CANONICAL=A0AAA9SJY1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJY1/entry#A0AAA9SJY1-1", "sequence": { "sequence": "MGLPLAWLSQRCRHLLLPSWAPILQGSWRCCSQGPRSTAETSSTRNRKMSPSRERQPRPTAELAQAEELLEQQLELYQALVEGQEGAWEAQALVLKTQKLKEQMRRQREPGRSHLSFPSVAPSPSSPENCTPPSDQQHPSLSQALRKQKKLPQKG", "length": 155, "header": "tr|A0AAA9SJY1-1|A0AAA9SJY1_BOVIN Isoform 1 of Mitochondrial coiled-coil domain 1 OS=Bos taurus OX=9913 GN=MCCD1 PE=4 SV=1 CANONICAL=A0AAA9SJY1-1" }, "locus": { "chromosome": "23", "start_pos": 27760332, "end_pos": 27759184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129058.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129058.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084227.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084227.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617505", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617505", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJZ3-1", "uniprot_ac": "A0AAA9SJZ3", "uniprot_id": "A0AAA9SJZ3_BOVIN", "mass": { "chemical_mass": 20149.0, "monoisotopic_mass": 20149.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "BPTI/Kunitz inhibitor domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJZ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJZ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22592", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22592", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10083:SF367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10083:SF367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLLTPEDTGLWEISGPRSQSKKEAEPGFRLRCSDCKTTEERVERRDGCRQSSKPPTNPLQPVLRSTQTDRFPVAKTSILRSPPEGHEDEPALPLCSPSPSPGHPDDQHPSGDTSCKDNVLQPHFGLEPPYRGPCKSVNVRYFFNASSTFWEPFVYGGCDAKENNLLRAADLRRTCGGSLGH", "length": 182, "header": "tr|A0AAA9SJZ3-1|A0AAA9SJZ3_BOVIN Isoform 1 of BPTI/Kunitz inhibitor domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SJZ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3/entry#A0AAA9SJZ3-1", "sequence": { "sequence": "MTLLTPEDTGLWEISGPRSQSKKEAEPGFRLRCSDCKTTEERVERRDGCRQSSKPPTNPLQPVLRSTQTDRFPVAKTSILRSPPEGHEDEPALPLCSPSPSPGHPDDQHPSGDTSCKDNVLQPHFGLEPPYRGPCKSVNVRYFFNASSTFWEPFVYGGCDAKENNLLRAADLRRTCGGSLGH", "length": 182, "header": "tr|A0AAA9SJZ3-1|A0AAA9SJZ3_BOVIN Isoform 1 of BPTI/Kunitz inhibitor domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SJZ3-1" }, "locus": { "chromosome": "13", "start_pos": 73791815, "end_pos": 73786244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130024.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130024.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084167.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084167.1" } ] } }, { "isoform_ac": "A0AAA9SSN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3/entry#A0AAA9SSN5-1", "sequence": { "sequence": "KAQSIPSILRSPPEGHEDEPALPLCSPSPSPGHPDDQHPSGDTSCKDNVLQPHFGLEPPYRGPCKSVNVRYFFNASSTFWEPFVYGGCDAKENNLLRAADLRRTCGGSLGH", "length": 111, "header": "tr|A0AAA9SSN5-1|A0AAA9SSN5_BOVIN Computationally mapped isoform of BPTI/Kunitz inhibitor domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SJZ3-1" }, "locus": { "chromosome": "13", "start_pos": 73791815, "end_pos": 73787146, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108767.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108767.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089389.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089389.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJZ3" }, { "id": "PS50279", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50279" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BPTI/Kunitz inhibitor", "eco_id": "ECO_0000259", "start_pos": 126, "end_pos": 176, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 145, "end_pos": 147 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK04-1", "uniprot_ac": "A0AAA9SK04", "uniprot_id": "A0AAA9SK04_BOVIN", "mass": { "chemical_mass": 35176.0, "monoisotopic_mass": 35176.0 }, "refseq": { "ac": "NP_001377046", "name": "olfactory receptor family 2 subfamily B member 8K", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377046" }, "gene_names": [ { "name": "OR2B8K", "type": "recommended", "evidence": [ { "id": "A0AAA9SK04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04" } ] }, { "name": "OR2B8K", "type": "synonym", "evidence": [ { "id": "NP_001377046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377046" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SK04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 2 subfamily B member 8K", "type": "synonym", "evidence": [ { "id": "NP_001377046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377046" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377046" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2B8K", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04", "locus": { "chromosome": "23", "start_pos": 30653775, "end_pos": 30652837, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057671", "url": "https://www.ensembl.org/id/ENSBTAG00000057671" } ] } } ], "crossref": [ { "id": "A0AAA9SK04", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK04", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529518", "url": "https://www.ncbi.nlm.nih.gov/gene/529518", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529518", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529518", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377046", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SK04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQKNGSSFTGFILLGFSDRPQLELVLFVVLLIFYVFTLLGNTTIIALSYLDPRLHTPMYFFLSNLSFLDMCYTTSIVPQFLFNLSGEDKSISFGGCVVQMYISLALGCTECILLGVMAFDRYAAVCRPLHYTVIMHPRLCALMASASWVTGFAISLLQTVLIFLLPLCGRNKLAHFFCEIPPFLKLACVDTTMNVYATFFASIIILLTPVSLIMFSYGRIVRAVLRIKSTTGRRKAFGTCGSHFTVVSLFFGTAIYVYFQPSSSDNQDQEKFMSLFYTVIIPMTNPLIYTLRNRDVKGAMKKVLWKDPDSR", "length": 312, "header": "tr|A0AAA9SK04-1|A0AAA9SK04_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2B8K PE=3 SV=1 CANONICAL=A0AAA9SK04-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04/entry#A0AAA9SK04-1", "sequence": { "sequence": "MEQKNGSSFTGFILLGFSDRPQLELVLFVVLLIFYVFTLLGNTTIIALSYLDPRLHTPMYFFLSNLSFLDMCYTTSIVPQFLFNLSGEDKSISFGGCVVQMYISLALGCTECILLGVMAFDRYAAVCRPLHYTVIMHPRLCALMASASWVTGFAISLLQTVLIFLLPLCGRNKLAHFFCEIPPFLKLACVDTTMNVYATFFASIIILLTPVSLIMFSYGRIVRAVLRIKSTTGRRKAFGTCGSHFTVVSLFFGTAIYVYFQPSSSDNQDQEKFMSLFYTVIIPMTNPLIYTLRNRDVKGAMKKVLWKDPDSR", "length": 312, "header": "tr|A0AAA9SK04-1|A0AAA9SK04_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2B8K PE=3 SV=1 CANONICAL=A0AAA9SK04-1" }, "locus": { "chromosome": "23", "start_pos": 30653772, "end_pos": 30652837, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115448.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115448.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084253.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084253.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529518", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529518", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK04" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK06-1", "uniprot_ac": "A0AAA9SK06", "uniprot_id": "A0AAA9SK06_BOVIN", "mass": { "chemical_mass": 19260.0, "monoisotopic_mass": 19260.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Serine/arginine-rich splicing factor 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SK06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06/entry#names_and_taxonomy" } ] }, { "name": "Splicing factor, arginine/serine-rich 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SK06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06#function" }, { "database": "UniProtKB", "id": "ARBA00056175", "url": "https://www.uniprot.org/uniprotkb/ARBA00056175#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06", "locus": {} } ], "crossref": [ { "id": "A0AAA9SK06", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK06", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12645", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12645", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSSDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK", "length": 164, "header": "tr|A0AAA9SK06-1|A0AAA9SK06_BOVIN Isoform 1 of Serine/arginine-rich splicing factor 3 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SK06-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06/entry#A0AAA9SK06-1", "sequence": { "sequence": "MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSSDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK", "length": 164, "header": "tr|A0AAA9SK06-1|A0AAA9SK06_BOVIN Isoform 1 of Serine/arginine-rich splicing factor 3 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SK06-1" }, "locus": { "chromosome": "5", "start_pos": 101641949, "end_pos": 101641458, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092557.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092557.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086639.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK06" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 83, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK49-1", "uniprot_ac": "A0AAA9SK49", "uniprot_id": "A0AAA9SK49_BOVIN", "mass": { "chemical_mass": 119877.0, "monoisotopic_mass": 119877.0 }, "refseq": {}, "gene_names": [ { "name": "TLR8", "type": "recommended", "evidence": [ { "id": "A0AAA9SK49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ] } ], "protein_names": [ { "name": "Toll-like receptor 9", "type": "recommended", "evidence": [ { "id": "A0AAA9SK49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49#function" }, { "database": "UniProtKB", "id": "ARBA00094474", "url": "https://www.uniprot.org/uniprotkb/ARBA00094474#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TLR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49", "locus": { "chromosome": "X", "start_pos": 130720584, "end_pos": 130767413, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031020", "url": "https://www.ensembl.org/id/ENSBTAG00000031020" } ] } } ], "crossref": [ { "id": "A0AAA9SK49", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK49", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47410", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47410", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47410:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47410:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRWLDVITDSMDENMTLHFLLLTSLFLLISDSCEFFTEASYPRSYPCDVKNENGSFIAECNGRRLQEVPQTVDKDVTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSQSGNPAVKKAMTITDGAFLNLKHLRELLLEDNQLQQIPAGLPESLKKLSLIQNNIITLTKKNTSGLGNLESLYLGWNCYFACDKKFTIENGAFQNLTKLKVLSLSFNPLHSVPPSLPSSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNCPRCFNAPFPCVPCQGDASIQIHPLAFQTLTQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLMDEIASGEFLTKLPSLEILDLSYNYELKKYPQYINISKNFSKLISLQMLHLRGYVFQELRKEDFEPLRNLSNLTTINLGVNFIKQIDFSIFHWFPNLKIIYLSENRISPLVSDTEQHDANGTSFQSHILKRRSADIQFDPHSNFYHNTRPLIKTECSRLGSALDLSLNSIFFIGVSQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNAHYFRIAGVTHRLGFIEHLTNLRVLNLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLTNLTRLDLARNNLRHISSQAFLNLPRTLTDLYINDNMLNFFNWSLLEYFPHLRLLDLSGNQLFFLTNSLSTFASSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLELGGNPFDCTCDFGDFLEWMDRNLNVRVPRLTDVICASPGDQEGKSIVSLDLSTCVSDTIAAIFCFLTFSVTISVMLAALAHHWFYWDAWFIYHVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRFHLEESEDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKNWNFKTAFYLALQRLMEENMDVIVFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQSLKNVVLTANDSRYNNLYVNSIKQY", "length": 1047, "header": "tr|A0AAA9SK49-1|A0AAA9SK49_BOVIN Isoform 1 of Toll-like receptor 9 OS=Bos taurus OX=9913 GN=TLR8 PE=3 SV=1 CANONICAL=A0AAA9SK49-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49/entry#A0AAA9SK49-1", "sequence": { "sequence": "MRWLDVITDSMDENMTLHFLLLTSLFLLISDSCEFFTEASYPRSYPCDVKNENGSFIAECNGRRLQEVPQTVDKDVTEVDLSDNFITRVTNESFQGLQNLTKINLNHNAKSQSGNPAVKKAMTITDGAFLNLKHLRELLLEDNQLQQIPAGLPESLKKLSLIQNNIITLTKKNTSGLGNLESLYLGWNCYFACDKKFTIENGAFQNLTKLKVLSLSFNPLHSVPPSLPSSLTELYLSNTHIGNVSEEDFKELSNLRVLDLSGNCPRCFNAPFPCVPCQGDASIQIHPLAFQTLTQLRYLNLSSTSLRKVPASWFDNMHNLKVLDLEFNYLMDEIASGEFLTKLPSLEILDLSYNYELKKYPQYINISKNFSKLISLQMLHLRGYVFQELRKEDFEPLRNLSNLTTINLGVNFIKQIDFSIFHWFPNLKIIYLSENRISPLVSDTEQHDANGTSFQSHILKRRSADIQFDPHSNFYHNTRPLIKTECSRLGSALDLSLNSIFFIGVSQFKDFGNISCLNLSSNGNGQVLNGTEFSCLSGIKYLDLTNNRLDFDDDAAFSELPLLEVLDLSYNAHYFRIAGVTHRLGFIEHLTNLRVLNLSNNDIFTLTETQLKSASLGELVFSGNRLDLLWNAQDVRYWQIFQNLTNLTRLDLARNNLRHISSQAFLNLPRTLTDLYINDNMLNFFNWSLLEYFPHLRLLDLSGNQLFFLTNSLSTFASSLETLLLSRNRISHLPSDFLSGASSLIHLDLNSNQLKMLNRSTFETKTATKLTVLELGGNPFDCTCDFGDFLEWMDRNLNVRVPRLTDVICASPGDQEGKSIVSLDLSTCVSDTIAAIFCFLTFSVTISVMLAALAHHWFYWDAWFIYHVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRFHLEESEDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTKKYAKNWNFKTAFYLALQRLMEENMDVIVFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQSLKNVVLTANDSRYNNLYVNSIKQY", "length": 1047, "header": "tr|A0AAA9SK49-1|A0AAA9SK49_BOVIN Isoform 1 of Toll-like receptor 9 OS=Bos taurus OX=9913 GN=TLR8 PE=3 SV=1 CANONICAL=A0AAA9SK49-1" }, "locus": { "chromosome": "X", "start_pos": 130742094, "end_pos": 130729217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101440.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101440.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085680.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "positive regulation of type II interferon production", "id": "GO:0032729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "positive regulation of interleukin-8 production", "id": "GO:0032757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032757", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "positive regulation of interleukin-1 beta production", "id": "GO:0032731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 9 signaling pathway", "id": "GO:0034165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "toll-like receptor 8 signaling pathway", "id": "GO:0034158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "unmethylated CpG binding", "id": "GO:0045322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045322", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" }, { "name": "pattern recognition receptor activity", "id": "GO:0038187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1032, "end_pos": 1034, "annotation": "n_glycosylation_sequon" }, { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" }, { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" }, { "start_pos": 758, "end_pos": 760, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" }, { "start_pos": 943, "end_pos": 945, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK49" }, { "id": "PS50104", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50104" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TIR", "eco_id": "ECO_0000259", "start_pos": 884, "end_pos": 1028, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1032, "end_pos": 1034 }, { "start_pos": 14, "end_pos": 16 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 365, "end_pos": 367 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 399, "end_pos": 401 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 450, "end_pos": 452 }, { "start_pos": 513, "end_pos": 515 }, { "start_pos": 518, "end_pos": 520 }, { "start_pos": 529, "end_pos": 531 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 597, "end_pos": 599 }, { "start_pos": 643, "end_pos": 645 }, { "start_pos": 646, "end_pos": 648 }, { "start_pos": 686, "end_pos": 688 }, { "start_pos": 758, "end_pos": 760 }, { "start_pos": 91, "end_pos": 93 }, { "start_pos": 943, "end_pos": 945 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK85-1", "uniprot_ac": "A0AAA9SK85", "uniprot_id": "A0AAA9SK85_BOVIN", "mass": { "chemical_mass": 24086.0, "monoisotopic_mass": 24086.0 }, "refseq": {}, "gene_names": [ { "name": "SNX22", "type": "recommended", "evidence": [ { "id": "A0AAA9SK85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85" } ] } ], "protein_names": [ { "name": "Sorting nexin 22", "type": "synonym", "evidence": [ { "id": "A0AAA9SK85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85", "locus": { "chromosome": "10", "start_pos": 45824595, "end_pos": 45830579, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016821", "url": "https://www.ensembl.org/id/ENSBTAG00000016821" } ] } } ], "crossref": [ { "id": "A0AAA9SK85", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK85", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06880", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06880", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15813", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15813", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15813:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15813:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RVQ5", "url": "https://www.uniprot.org/uniprotkb/F6RVQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RVQ5-1", "url": "https://www.uniprot.org/uniprotkb/F6RVQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GTDCTGQSPQVCGSVGGSLESSGAPRPLCASAGGGWAGGVSGSGAACALAPGLTRTRLPAGVHQVFRVEVLCRGRRHIVQRRYREFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQDVPKELLEFLSLRHWPTDPKASNRGSQLYHRPVVSFPMDPYICTPSPEPLPSVVVQGVLQGLYGFNATIAEAQPEAAHHPAPMPPTP", "length": 221, "header": "tr|A0AAA9SK85-1|A0AAA9SK85_BOVIN Isoform 1 of Sorting nexin 22 OS=Bos taurus OX=9913 GN=SNX22 PE=3 SV=1 CANONICAL=A0AAA9SK85-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85/entry#A0AAA9SK85-1", "sequence": { "sequence": "GTDCTGQSPQVCGSVGGSLESSGAPRPLCASAGGGWAGGVSGSGAACALAPGLTRTRLPAGVHQVFRVEVLCRGRRHIVQRRYREFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQDVPKELLEFLSLRHWPTDPKASNRGSQLYHRPVVSFPMDPYICTPSPEPLPSVVVQGVLQGLYGFNATIAEAQPEAAHHPAPMPPTP", "length": 221, "header": "tr|A0AAA9SK85-1|A0AAA9SK85_BOVIN Isoform 1 of Sorting nexin 22 OS=Bos taurus OX=9913 GN=SNX22 PE=3 SV=1 CANONICAL=A0AAA9SK85-1" }, "locus": { "chromosome": "10", "start_pos": 45830313, "end_pos": 45825256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090140.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090140.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084288.1" } ] } }, { "isoform_ac": "F6RVQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85/entry#F6RVQ5-1", "sequence": { "sequence": "MLEVHIPSVGPEKGHMVFRVEVLCRGRRHIVQRRYREFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQDVPKELLEFLSLRHWPTDPKASNRGSLGECLPDNSSQLYHRPVVSFPMDPYICTPSPEPLPSVVVQGVLQGLYGFNATIAEAQPEAAHHPAPMPPTP", "length": 183, "header": "tr|F6RVQ5-1|F6RVQ5_BOVIN Computationally mapped isoform of Sorting nexin 22 OS=Bos taurus OX=9913 GN=SNX22 PE=3 SV=1 CANONICAL=A0AAA9SK85-1" }, "locus": { "chromosome": "10", "start_pos": 45830538, "end_pos": 45825256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022377.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022377.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022377.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022377.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 220, "start_aa": "Thr", "end_pos": 220, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr220", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK85" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 151, "start_aa": "Gly", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 220 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 200, "end_pos": 202 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SK94-1", "uniprot_ac": "A0AAA9SK94", "uniprot_id": "A0AAA9SK94_BOVIN", "mass": { "chemical_mass": 41535.0, "monoisotopic_mass": 41535.0 }, "refseq": {}, "gene_names": [ { "name": "MRM1", "type": "recommended", "evidence": [ { "id": "A0AAA9SK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ] } ], "protein_names": [ { "name": "rRNA methyltransferase 1, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94/entry#names_and_taxonomy" } ] }, { "name": "16S rRNA (guanosine(1145)-2'-O)-methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94/entry#names_and_taxonomy" } ] }, { "name": "16S rRNA [Gm1145] 2'-O-methyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9SK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94#function" }, { "database": "UniProtKB", "id": "ARBA00055894", "url": "https://www.uniprot.org/uniprotkb/ARBA00055894#function" }, { "database": "UniProtKB", "id": "F6R642", "url": "https://www.uniprot.org/uniprotkb/F6R642#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94", "locus": { "chromosome": "19", "start_pos": 12951099, "end_pos": 12941297, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010311", "url": "https://www.ensembl.org/id/ENSBTAG00000010311" } ] } } ], "crossref": [ { "id": "A0AAA9SK94", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SK94", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18105", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18105", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46103:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46103:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00588", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00588", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08032", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08032", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "47776", "url": "https://www.rhea-db.org/rhea/47776", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R642", "url": "https://www.uniprot.org/uniprotkb/F6R642", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R642-1", "url": "https://www.uniprot.org/uniprotkb/F6R642-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALPPAVGTATWPCCSLPLTRPFSQATRRWGRPGGEELGRLPLDDLASMPRSAGGPELLFGLSPCLLALRAARRRVARLLLQACRSGLQGQRAELLRAAEERAIPVLRPRRRELDVLCRHQVHQGVCMEVSPLRPRPWAEAEVARPGDDPQQLWLVLEGLQDPRNLGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKASAGAMEVMDVFSTDDLAGFLQARARQGWLVAGTVGCPGPEIALSSKIPVTRCLDFLWDRPTLLVLGNEGSGLSRAVQASCQLLLTILPGRQLPPGLESLNVSVAAARGRGSQWNGGESNFSMTPRIPRPHLKQPEWLSTQDCPQDQKRRDKTGANRDCPWCLCAGERTHPHPRMCWSLFVL", "length": 379, "header": "tr|A0AAA9SK94-1|A0AAA9SK94_BOVIN Isoform 1 of rRNA methyltransferase 1, mitochondrial OS=Bos taurus OX=9913 GN=MRM1 PE=3 SV=1 CANONICAL=A0AAA9SK94-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94/entry#A0AAA9SK94-1", "sequence": { "sequence": "MALPPAVGTATWPCCSLPLTRPFSQATRRWGRPGGEELGRLPLDDLASMPRSAGGPELLFGLSPCLLALRAARRRVARLLLQACRSGLQGQRAELLRAAEERAIPVLRPRRRELDVLCRHQVHQGVCMEVSPLRPRPWAEAEVARPGDDPQQLWLVLEGLQDPRNLGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKASAGAMEVMDVFSTDDLAGFLQARARQGWLVAGTVGCPGPEIALSSKIPVTRCLDFLWDRPTLLVLGNEGSGLSRAVQASCQLLLTILPGRQLPPGLESLNVSVAAARGRGSQWNGGESNFSMTPRIPRPHLKQPEWLSTQDCPQDQKRRDKTGANRDCPWCLCAGERTHPHPRMCWSLFVL", "length": 379, "header": "tr|A0AAA9SK94-1|A0AAA9SK94_BOVIN Isoform 1 of rRNA methyltransferase 1, mitochondrial OS=Bos taurus OX=9913 GN=MRM1 PE=3 SV=1 CANONICAL=A0AAA9SK94-1" }, "locus": { "chromosome": "19", "start_pos": 12950095, "end_pos": 12941324, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115670.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115670.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086728.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086728.1" } ] } }, { "isoform_ac": "F6R642-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94/entry#F6R642-1", "sequence": { "sequence": "MALPPAVGTATWPCCSLPLTRPFSQATRRWGRPGGEELGRLPLDDLASMPRSAGGPELLFGLSPCLLALRAARRRVARLLLQACRSGLQGQRAELLRAAEERAIPVLRPRRRELDVLCRHQVHQGVCMEVSPLRPRPWAEAEVARPGDDPQQLWLVLEGLQDPRNLGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKASAGAMEVMDVFSTDDLAGFLQQLPFHWLLGCSAVPHACLARARQGWLVAGTVGCPGPEIALSSKIPVTRCLDFLWDRPTLLVLGNEGSGLSRAVQASCQLLLTILPGRQLPPGLESLNVSVAAGILLHSICSQRKGFPVERRREQLLHDPQDPSASSEAARVAQHPGLSSGSEKKRQDGG", "length": 378, "header": "tr|F6R642-1|F6R642_BOVIN Computationally mapped isoform of rRNA methyltransferase 1, mitochondrial OS=Bos taurus OX=9913 GN=MRM1 PE=3 SV=1 CANONICAL=A0AAA9SK94-1" }, "locus": { "chromosome": "19", "start_pos": 12950013, "end_pos": 12941324, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013616.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013616.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013616.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013616.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ], "pmid": "" }, { "name": "rRNA (guanosine-2'-O-)-methyltransferase activity", "id": "GO:0070039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ], "pmid": "" }, { "name": "RNA methyltransferase activity", "id": "GO:0008173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008173", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA methylation", "id": "GO:0031167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031167", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "47776", "name": "", "equation": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "47776", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47776" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK94" }, { "id": "SM00967", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00967" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RNA 2-O ribose methyltransferase substrate binding", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 136, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 317, "end_pos": 319 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKB5-1", "uniprot_ac": "A0AAA9SKB5", "uniprot_id": "A0AAA9SKB5_BOVIN", "mass": { "chemical_mass": 35971.0, "monoisotopic_mass": 35971.0 }, "refseq": { "ac": "NP_001377635", "name": "olfactory receptor family 1 subfamily L member 8E", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377635" }, "gene_names": [ { "name": "OR1L8E", "type": "recommended", "evidence": [ { "id": "A0AAA9SKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5" } ] }, { "name": "OR1L8E", "type": "synonym", "evidence": [ { "id": "NP_001377635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377635" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 1L8", "type": "synonym", "evidence": [ { "id": "NP_001377635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377635" } ] }, { "name": "olfactory receptor family 1 subfamily L member 8E", "type": "synonym", "evidence": [ { "id": "NP_001377635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377635" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377635" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1L8E", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5", "locus": { "chromosome": "11", "start_pos": 93368888, "end_pos": 93367941, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062570", "url": "https://www.ensembl.org/id/ENSBTAG00000062570" } ] } } ], "crossref": [ { "id": "A0AAA9SKB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337234", "url": "https://www.ncbi.nlm.nih.gov/gene/100337234", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100337234", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337234", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRCKSMERLNQTSRVSEFILLGLSSLPEDQKPLFIIFFIIYLVTITGNLLIILAIHSDSQLQTPMYFFLSFLSFIDICFTTTIVPRMLVNFLSHKTISYAGCLTQMYFIYALGNTDSWLLVVMAFDRYVAICDPFHYVTIMSHHRCVLLVAFSCSLPHFHSLLHTLLLNQVTFCDSNIIHHFLCDFSPLVKLSCSSTFVNEIVMMIEGSVFLVTPFLCITFSYIRILLAVLKIPSAAGKCKAFSTCGSHLTVVTLFYGSIFYVYLQPVSTYTVRDHMATIVYTVLTSTLNPFIYSLRNKDLKQGLRKLLVRRKP", "length": 315, "header": "tr|A0AAA9SKB5-1|A0AAA9SKB5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1L8E PE=3 SV=1 CANONICAL=A0AAA9SKB5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5/entry#A0AAA9SKB5-1", "sequence": { "sequence": "MTRCKSMERLNQTSRVSEFILLGLSSLPEDQKPLFIIFFIIYLVTITGNLLIILAIHSDSQLQTPMYFFLSFLSFIDICFTTTIVPRMLVNFLSHKTISYAGCLTQMYFIYALGNTDSWLLVVMAFDRYVAICDPFHYVTIMSHHRCVLLVAFSCSLPHFHSLLHTLLLNQVTFCDSNIIHHFLCDFSPLVKLSCSSTFVNEIVMMIEGSVFLVTPFLCITFSYIRILLAVLKIPSAAGKCKAFSTCGSHLTVVTLFYGSIFYVYLQPVSTYTVRDHMATIVYTVLTSTLNPFIYSLRNKDLKQGLRKLLVRRKP", "length": 315, "header": "tr|A0AAA9SKB5-1|A0AAA9SKB5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1L8E PE=3 SV=1 CANONICAL=A0AAA9SKB5-1" }, "locus": { "chromosome": "11", "start_pos": 93368885, "end_pos": 93367941, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130715.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130715.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083044.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100337234", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337234", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKB5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 295, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKC9-1", "uniprot_ac": "A0AAA9SKC9", "uniprot_id": "A0AAA9SKC9_BOVIN", "mass": { "chemical_mass": 52284.0, "monoisotopic_mass": 52284.0 }, "refseq": {}, "gene_names": [ { "name": "SAXO2", "type": "recommended", "evidence": [ { "id": "A0AAA9SKC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9" } ] } ], "protein_names": [ { "name": "Stabilizer of axonemal microtubules 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SKC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAXO2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9", "locus": { "chromosome": "21", "start_pos": 24073794, "end_pos": 24054885, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063122", "url": "https://www.ensembl.org/id/ENSBTAG00000063122" } ] } } ], "crossref": [ { "id": "A0AAA9SKC9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKC9", "database": "AlphaFoldDB", "categories": [] }, { "id": "538044", "url": "https://www.ncbi.nlm.nih.gov/gene/538044", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31516", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31516", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31516:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31516:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWL0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GTGSMKTWCLCQICTCGRHHCPHGTTRIYENSGESCATTEYLEKYPSYGSVLPPQSLKPKEEFRAYRGKMEGITTFKSDYRPYEIDKQPRHAPEGYKPKQGVIDLGTTYKRDFNSYKVQPVVIIRPLERQQVKKGKLDTVPTYKDDYRAWDIQKSELYKPQQTYYPPTVRFGNSTTFQDDYVPREIKPRQSCKPSPAVERSTIPFSCNTSHRLDYVPHRPEFNLARPKDSYKPPDQPLEDLTTHRCDFQGLVGETAKICRPAHTRVAQDAPFEGSTEFRDSFQAWALPAPQVQKALEYVPPAGTMQLQSTSHLDYVPHQATRVLPIRPASRRRNHNFPFQGKSTTKQDFPAWESCRQGLIKQGPQIPSPSGKFDGLSTFRSHYVPHELIATESCKPADAPLKRPLPFDDITTYSLEYMPKKLETCPASYPSPPGYLFETTNSQGHKFFRKIAPAVKAF", "length": 458, "header": "tr|A0AAA9SKC9-1|A0AAA9SKC9_BOVIN Isoform 1 of Stabilizer of axonemal microtubules 2 OS=Bos taurus OX=9913 GN=SAXO2 PE=3 SV=1 CANONICAL=A0AAA9SKC9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9/entry#A0AAA9SKC9-1", "sequence": { "sequence": "GTGSMKTWCLCQICTCGRHHCPHGTTRIYENSGESCATTEYLEKYPSYGSVLPPQSLKPKEEFRAYRGKMEGITTFKSDYRPYEIDKQPRHAPEGYKPKQGVIDLGTTYKRDFNSYKVQPVVIIRPLERQQVKKGKLDTVPTYKDDYRAWDIQKSELYKPQQTYYPPTVRFGNSTTFQDDYVPREIKPRQSCKPSPAVERSTIPFSCNTSHRLDYVPHRPEFNLARPKDSYKPPDQPLEDLTTHRCDFQGLVGETAKICRPAHTRVAQDAPFEGSTEFRDSFQAWALPAPQVQKALEYVPPAGTMQLQSTSHLDYVPHQATRVLPIRPASRRRNHNFPFQGKSTTKQDFPAWESCRQGLIKQGPQIPSPSGKFDGLSTFRSHYVPHELIATESCKPADAPLKRPLPFDDITTYSLEYMPKKLETCPASYPSPPGYLFETTNSQGHKFFRKIAPAVKAF", "length": 458, "header": "tr|A0AAA9SKC9-1|A0AAA9SKC9_BOVIN Isoform 1 of Stabilizer of axonemal microtubules 2 OS=Bos taurus OX=9913 GN=SAXO2 PE=3 SV=1 CANONICAL=A0AAA9SKC9-1" }, "locus": { "chromosome": "21", "start_pos": 24072241, "end_pos": 24055205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123776.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123776.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084330.1" } ] } }, { "isoform_ac": "A0AAA9SQ37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9/entry#A0AAA9SQ37-1", "sequence": { "sequence": "MPVQQRRSSWRHHCPHGTTRIYENSGESCATTEYLEKYPSYGSVLPPQSLKPKEEFRAYRGKMEGITTFKSDYRPYEIDKQPRHAPEGYKPKQGVIDLGTTYKRDFNSYKVQPVVIIRPLERQQVKKGKLDTVPTYKDDYRAWDIQKSELYKPQQTYYPPTVRFGNSTTFQDDYVPREIKPRQSCKPSPAVERSTIPFSCNTSHRLDYVPHRPEFNLARPKDSYKPPDQPLEDLTTHRCDFQGLVGETAKICRPAHTRVAQDAPFEGSTEFRDSFQAWALPAPQVQKALEYVPPAGTMQLQSTSHLDYVPHQATRVLPIRPASRRRNHNFPFQGKSTTKQDFPAWESCRQGLIKQGPQIPSPSGKFDGLSTFRSHYVPHELIATESCKPADAPLKRPLPFDDITTYSLEYMPKKLETCPASYPSPPGYLFETTNSQGHKFFRKIAPAVKAF", "length": 451, "header": "tr|A0AAA9SQ37-1|A0AAA9SQ37_BOVIN Computationally mapped isoform of Stabilizer of axonemal microtubules 2 OS=Bos taurus OX=9913 GN=SAXO2 PE=3 SV=1 CANONICAL=A0AAA9SKC9-1" }, "locus": { "chromosome": "21", "start_pos": 24072241, "end_pos": 24055991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103886.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103886.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088438.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088438.1" } ] } }, { "isoform_ac": "A0AAA9SWL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9/entry#A0AAA9SWL0-1", "sequence": { "sequence": "GTGSMKTWCLCQICTCGSDYRPYEIDKQPRHAPEGYKPKQGVIDLGTTYKRDFNSYKVQPVVIIRPLERQQVKKGKLDTVPTYKDDYRAWDIQKSELYKPQQTYYPPTVRFGNSTTFQDDYVPREIKPRQSCKPSPAVERSTIPFSCNTSHRLDYVPHRPEFNLARPKDSYKPPDQPLEDLTTHRCDFQGLVGETAKICRPAHTRVAQDAPFEGSTEFRDSFQAWALPAPQVQKALEYVPPAGTMQLQSTSHLDYVPHQATRVLPIRPASRRRNHNFPFQGKSTTKQDFPAWESCRQGLIKQGPQIPSPSGKFDGLSTFRSHYVPHELIATESCKPADAPLKRPLPFDDITTYSLEYMPKKLETCPASYPSPPGYLFETTNSQGHKFFRKIAPAVKAF", "length": 398, "header": "tr|A0AAA9SWL0-1|A0AAA9SWL0_BOVIN Computationally mapped isoform of Stabilizer of axonemal microtubules 2 OS=Bos taurus OX=9913 GN=SAXO2 PE=3 SV=1 CANONICAL=A0AAA9SKC9-1" }, "locus": { "chromosome": "21", "start_pos": 24072241, "end_pos": 24055205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123970.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123970.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089708.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089708.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 208, "end_pos": 210 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKD6-1", "uniprot_ac": "A0AAA9SKD6", "uniprot_id": "A0AAA9SKD6_BOVIN", "mass": { "chemical_mass": 34872.0, "monoisotopic_mass": 34872.0 }, "refseq": { "ac": "NP_001377662", "name": "olfactory receptor family 5 subfamily B member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377662" }, "gene_names": [ { "name": "OR5B2", "type": "recommended", "evidence": [ { "id": "A0AAA9SKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6" } ] }, { "name": "OR5B2", "type": "synonym", "evidence": [ { "id": "NP_001377662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377662" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 5 subfamily B member 2", "type": "synonym", "evidence": [ { "id": "NP_001377662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377662" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377662" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5B2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6", "locus": { "chromosome": "15", "start_pos": 81592398, "end_pos": 81593351, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059595", "url": "https://www.ensembl.org/id/ENSBTAG00000059595" } ] } } ], "crossref": [ { "id": "A0AAA9SKD6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15407", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15407", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "104968563", "url": "https://www.ncbi.nlm.nih.gov/gene/104968563", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968563", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968563", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377662", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENSAEVTGFILLGLSSAPELRSLLCIMLTLIYLVTLVGNLGMITLILLGSHLHTPMYFFLSNLSLVDFGYSSAVTPKAVAGLLIGDKFISYNACAAQMFFFVAFATVENYLLASMAYDRYAAVCRPLHYTTTMTTSVCAHLAIGSYICGFLNACFHVGDIFSLTFCKSNTVHHFFCDVPAVLALSCSEKHVSEVVLVFMSSFNVSFALLVILISYLFIFVNILKMHSAQSHQKALSTCASHFTAVSIFYGTLIFMYLQPSSRHSMDTDKVASVFYAMVIPMLNPVVYSLRNKEVKSAFKKVVEKTDISIGLGLLTL", "length": 317, "header": "tr|A0AAA9SKD6-1|A0AAA9SKD6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5B2 PE=3 SV=1 CANONICAL=A0AAA9SKD6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6/entry#A0AAA9SKD6-1", "sequence": { "sequence": "MENSAEVTGFILLGLSSAPELRSLLCIMLTLIYLVTLVGNLGMITLILLGSHLHTPMYFFLSNLSLVDFGYSSAVTPKAVAGLLIGDKFISYNACAAQMFFFVAFATVENYLLASMAYDRYAAVCRPLHYTTTMTTSVCAHLAIGSYICGFLNACFHVGDIFSLTFCKSNTVHHFFCDVPAVLALSCSEKHVSEVVLVFMSSFNVSFALLVILISYLFIFVNILKMHSAQSHQKALSTCASHFTAVSIFYGTLIFMYLQPSSRHSMDTDKVASVFYAMVIPMLNPVVYSLRNKEVKSAFKKVVEKTDISIGLGLLTL", "length": 317, "header": "tr|A0AAA9SKD6-1|A0AAA9SKD6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5B2 PE=3 SV=1 CANONICAL=A0AAA9SKD6-1" }, "locus": { "chromosome": "15", "start_pos": 81593351, "end_pos": 81592401, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135101.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135101.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086786.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086786.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104968563", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968563", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKD6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKG6-1", "uniprot_ac": "A0AAA9SKG6", "uniprot_id": "A0AAA9SKG6_BOVIN", "mass": { "chemical_mass": 43385.0, "monoisotopic_mass": 43385.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "SRY-box transcription factor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01388", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01388", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10270", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10270", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10270:SF231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10270:SF231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12336", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12336", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPWMEDERRIASSFNSFCPVRSDQAWADKRLREPSRSFAFLPANQTATRQHPDLAWTFPAGPRVGGRRRAGPAHSARMYNMMETELKPPGPQQTSGGGGGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM", "length": 399, "header": "tr|A0AAA9SKG6-1|A0AAA9SKG6_BOVIN Isoform 1 of SRY-box transcription factor 2 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SKG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6/entry#A0AAA9SKG6-1", "sequence": { "sequence": "MVPWMEDERRIASSFNSFCPVRSDQAWADKRLREPSRSFAFLPANQTATRQHPDLAWTFPAGPRVGGRRRAGPAHSARMYNMMETELKPPGPQQTSGGGGGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM", "length": 399, "header": "tr|A0AAA9SKG6-1|A0AAA9SKG6_BOVIN Isoform 1 of SRY-box transcription factor 2 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SKG6-1" }, "locus": { "chromosome": "1", "start_pos": 85316362, "end_pos": 85302414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090459.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090459.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083105.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083105.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 314, "start_aa": "Thr", "end_pos": 314, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr314", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "miRNA binding", "id": "GO:0035198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "pituitary gland development", "id": "GO:0021983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "response to growth factor", "id": "GO:0070848", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070848", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "osteoblast differentiation", "id": "GO:0001649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "inner ear development", "id": "GO:0048839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "somatic stem cell population maintenance", "id": "GO:0035019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035019", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" }, { "name": "negative regulation of cell cycle G1/S phase transition", "id": "GO:1902807", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902807", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKG6" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 123, "end_pos": 191, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 314 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKH3-1", "uniprot_ac": "A0AAA9SKH3", "uniprot_id": "A0AAA9SKH3_BOVIN", "mass": { "chemical_mass": 149147.0, "monoisotopic_mass": 149147.0 }, "refseq": {}, "gene_names": [ { "name": "GIGYF2", "type": "recommended", "evidence": [ { "id": "A0AAA9SKH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3" } ] } ], "protein_names": [ { "name": "GRB10 interacting GYF protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SKH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIGYF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3", "locus": { "chromosome": "3", "start_pos": 112584264, "end_pos": 112454968, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014079", "url": "https://www.ensembl.org/id/ENSBTAG00000014079" } ] } } ], "crossref": [ { "id": "cd00072", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00072", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14445", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14445", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14445:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14445:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIRRGRLHLGLLLRLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLLPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFVRGGGREMHRSQSWEERGDRRFDKPGRKDVGRPNFEEGGPVSVGRKHEFIRSESGNWRIFREEQNGEDEDGGWRLTGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEECSDSEGSHNEEAKEPDKTNKKEAEKTDRTGVEASEETTQTSSSSARPGSPSDQPQEAPQFERKEESKTEQMEKAEEESRTENSLSTKVSSRGDEVLPAVQQPLSQIPSDTASPLLILPPPVPSPSPALRPVETPVVGAPGMGSVPTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRISDQNIIPSVTRSVSVPDTGSIWELQPAPSQPTVWEGGSVWDLPLDPATPAPALEQLQQMEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKELLRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPAGTAKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSSADTKNSNMGFWDDAVKEVGPRNSTNKNKNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQRQQQQQQQQQQQQQQQQQQQDSVWGMNHSALHSVFQTNQTNNQQSSFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETVDDY", "length": 1291, "header": "tr|A0AAA9SKH3-1|A0AAA9SKH3_BOVIN Isoform 1 of GRB10 interacting GYF protein 2 OS=Bos taurus OX=9913 GN=GIGYF2 PE=3 SV=1 CANONICAL=A0AAA9SKH3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3/entry#A0AAA9SKH3-1", "sequence": { "sequence": "MIRRGRLHLGLLLRLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLLPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFVRGGGREMHRSQSWEERGDRRFDKPGRKDVGRPNFEEGGPVSVGRKHEFIRSESGNWRIFREEQNGEDEDGGWRLTGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEECSDSEGSHNEEAKEPDKTNKKEAEKTDRTGVEASEETTQTSSSSARPGSPSDQPQEAPQFERKEESKTEQMEKAEEESRTENSLSTKVSSRGDEVLPAVQQPLSQIPSDTASPLLILPPPVPSPSPALRPVETPVVGAPGMGSVPTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRISDQNIIPSVTRSVSVPDTGSIWELQPAPSQPTVWEGGSVWDLPLDPATPAPALEQLQQMEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKELLRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPAGTAKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSSADTKNSNMGFWDDAVKEVGPRNSTNKNKNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQRQQQQQQQQQQQQQQQQQQQDSVWGMNHSALHSVFQTNQTNNQQSSFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETVDDY", "length": 1291, "header": "tr|A0AAA9SKH3-1|A0AAA9SKH3_BOVIN Isoform 1 of GRB10 interacting GYF protein 2 OS=Bos taurus OX=9913 GN=GIGYF2 PE=3 SV=1 CANONICAL=A0AAA9SKH3-1" }, "locus": { "chromosome": "3", "start_pos": 112582527, "end_pos": 112487199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118691.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118691.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084378.1" } ] } }, { "isoform_ac": "A0AAA9TUB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3/entry#A0AAA9TUB6-1", "sequence": { "sequence": "MSLHRSAFRLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLLPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFVRGGGREMHRSQSWEERGDRRFDKPGRKDVGRPNFEEGGPVSVGRKHEFIRSESGNWRIFREEQNGEDEDGGWRLTGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEECSDSEGSHNEEAKEPDKTNKKEAEKTDRTGVEASEETTQTSSSSARPGSPSDQPQEAPQFERKEESKTEQMEKAEEESRTENSLSTKVSSRGDEVLPAVQQPLSQIPSDTASPLLILPPPVPSPSPALRPVETPVVGAPGMGSVPTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRISDQNIIPSVTRSVSVPDTGSIWELQPAPSQPTVWEGGSVWDLPLDPATPAPALEQLQQMEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKELLRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPAGTAKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSSADTKNSNMGFWDDAVKEVGPRNSTNKNKNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQRQQQQQQQQQQQQQQQQQQQDSVWGMNHSALHSVFQTNQTNNQQSSFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETVDDY", "length": 1286, "header": "tr|A0AAA9TUB6-1|A0AAA9TUB6_BOVIN Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Bos taurus OX=9913 GN=GIGYF2 PE=3 SV=1 CANONICAL=A0AAA9SKH3-1" }, "locus": { "chromosome": "3", "start_pos": 112582527, "end_pos": 112486961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092942.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092942.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101963.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1030, "end_pos": 1032, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1089, "end_pos": 1091, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1096, "end_pos": 1098, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1227, "end_pos": 1229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1238, "end_pos": 1240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1274, "end_pos": 1276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" }, { "start_pos": 933, "end_pos": 935, "annotation": "n_glycosylation_sequon" }, { "start_pos": 990, "end_pos": 992, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH3" }, { "id": "PS50829", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50829" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GYF", "eco_id": "ECO_0000259", "start_pos": 532, "end_pos": 580, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1030, "end_pos": 1032 }, { "start_pos": 1089, "end_pos": 1091 }, { "start_pos": 1096, "end_pos": 1098 }, { "start_pos": 1227, "end_pos": 1229 }, { "start_pos": 1238, "end_pos": 1240 }, { "start_pos": 1274, "end_pos": 1276 }, { "start_pos": 91, "end_pos": 93 }, { "start_pos": 933, "end_pos": 935 }, { "start_pos": 990, "end_pos": 992 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKI6-1", "uniprot_ac": "A0AAA9SKI6", "uniprot_id": "A0AAA9SKI6_BOVIN", "mass": { "chemical_mass": 83795.0, "monoisotopic_mass": 83795.0 }, "refseq": {}, "gene_names": [ { "name": "TRIM67", "type": "recommended", "evidence": [ { "id": "A0AAA9SKI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" } ] } ], "protein_names": [ { "name": "Tripartite motif-containing protein 67", "type": "recommended", "evidence": [ { "id": "A0AAA9SKI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6", "locus": { "chromosome": "28", "start_pos": 3964571, "end_pos": 3905773, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047877", "url": "https://www.ensembl.org/id/ENSBTAG00000047877" } ] } } ], "crossref": [ { "id": "A0AAA9SKI6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047877", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047877", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12889", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12889", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16758", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16758", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19827", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19827", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19844", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19844", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3MYU7", "url": "https://www.orthodb.org/?gene=G3MYU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22586", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22586", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYU7", "url": "https://www.uniprot.org/uniprotkb/G3MYU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYU7-1", "url": "https://www.uniprot.org/uniprotkb/G3MYU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEELKCPVCGSLFREPIILPCSHNVCLPCARTIAVQTPDGEQHLPPPLLHSRGSALSSGAAAAPPLDQEAAAGPACSGAGGSAAGGLGGGAGGGSDHADKLSLYSETDSGYGSYTPSLKSPNGVRVLPMVPAPPGSSAAAARGAACSSLSSSSSSITCPQCHRSASLDHRGLRGFQRNRLLEAIVQRYQQGRGAAPGASAVTAVAICQLCDRTPPEPAATLCEQCDVLYCAACQLKCHPSRGPFAKHRLVQPPPPPPSEVASGSPGAVQGAPSGSGGCKSPGATGAGAAGGNTARKYPTCPEHEMENYSMYCLTCRTPVCYLCLEEGRHGKHEVKPLGAMWKQHKAQLSQALNGVSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTRQKAKLLTKVTKEREHKLKMVWDQINHCTLKLRQSTGLMEYCLEVIKENDPAGFLQISDALIKRVQVSQEQWVKGALEPKVSAEFELTLDSEPLLQAIHQLDFIQMKCRVPPVPLLQLEKCCTRNNSVTLAWRTPPFTHSPVDGYILELDDGDGGQFREVYVGKETLCTIDGLHFNSTYNARVKAFNSSGVGPYSKTVVLQTSDVAWFTFDPNSGHRDIILSNDNQTATCSSYDDRVVLGTAAFSKGAHYWELHVDRYDNHPDPAFGVARASVVKDMMLGKDDKAWAMYVDNNRSWFMHCNSHTNRTEGGVCKGATVGVLLDLNKHTLTFFINGQQQGPTAFSHVDGVFMPALSLNRNVQVTLHTGLEVPTNLGRPKLSGN", "length": 781, "header": "tr|A0AAA9SKI6-1|A0AAA9SKI6_BOVIN Isoform 1 of Tripartite motif-containing protein 67 OS=Bos taurus OX=9913 GN=TRIM67 PE=4 SV=1 CANONICAL=A0AAA9SKI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6/entry#A0AAA9SKI6-1", "sequence": { "sequence": "MEEELKCPVCGSLFREPIILPCSHNVCLPCARTIAVQTPDGEQHLPPPLLHSRGSALSSGAAAAPPLDQEAAAGPACSGAGGSAAGGLGGGAGGGSDHADKLSLYSETDSGYGSYTPSLKSPNGVRVLPMVPAPPGSSAAAARGAACSSLSSSSSSITCPQCHRSASLDHRGLRGFQRNRLLEAIVQRYQQGRGAAPGASAVTAVAICQLCDRTPPEPAATLCEQCDVLYCAACQLKCHPSRGPFAKHRLVQPPPPPPSEVASGSPGAVQGAPSGSGGCKSPGATGAGAAGGNTARKYPTCPEHEMENYSMYCLTCRTPVCYLCLEEGRHGKHEVKPLGAMWKQHKAQLSQALNGVSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTRQKAKLLTKVTKEREHKLKMVWDQINHCTLKLRQSTGLMEYCLEVIKENDPAGFLQISDALIKRVQVSQEQWVKGALEPKVSAEFELTLDSEPLLQAIHQLDFIQMKCRVPPVPLLQLEKCCTRNNSVTLAWRTPPFTHSPVDGYILELDDGDGGQFREVYVGKETLCTIDGLHFNSTYNARVKAFNSSGVGPYSKTVVLQTSDVAWFTFDPNSGHRDIILSNDNQTATCSSYDDRVVLGTAAFSKGAHYWELHVDRYDNHPDPAFGVARASVVKDMMLGKDDKAWAMYVDNNRSWFMHCNSHTNRTEGGVCKGATVGVLLDLNKHTLTFFINGQQQGPTAFSHVDGVFMPALSLNRNVQVTLHTGLEVPTNLGRPKLSGN", "length": 781, "header": "tr|A0AAA9SKI6-1|A0AAA9SKI6_BOVIN Isoform 1 of Tripartite motif-containing protein 67 OS=Bos taurus OX=9913 GN=TRIM67 PE=4 SV=1 CANONICAL=A0AAA9SKI6-1" }, "locus": { "chromosome": "28", "start_pos": 3963567, "end_pos": 3905773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091664.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091664.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084427.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084427.1" } ] } }, { "isoform_ac": "G3MYU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6/entry#G3MYU7-1", "sequence": { "sequence": "MEEELKCPVCGSLFREPIILPCSHNVCLPCARTIAVQTPDGGSAAGGLGGGAGGGSDHADKLSLYSETDSGYGSYTPSLKSPNGVRVLPMVPAPPGSSAAAARGAACSSLSSSSSSITCPQCHRSASLDHRGLRGFQRNRLLEAIVQRYQQGRGAAPGASAVTAVAICQLCDRTPPEPAATLCEQCDVLYCAACQLKCHPSRGPFAKHRLGAPSGSGGCKSPGATGAGAAGGNTARKYPTCPEHEMENYSMYCLTCRTPVCYLCLEEGRHGKHEVKPLGAMWKQHKAQLSQALNGVSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTRQKAKLLTKVTKEREHKLKMVWDQINHCTLKLRQSTGLMEYCLEVIKENDPAGFLQISDALIKRVQVSQEQWVKGALEPKVSAEFELTLDSEPLLQAIHQLDFIQMKCRVPPVPLLQLEKCCTRNNSVTLAWRTPPFTHSPVDGYILELDDGDGGQFREVYVGKETLCTIDGLHFNSTYNARVKAFNSSGVGPYSKTVVLQTSDVAWFTFDPNSGHRDIILSNDNQTATCSSYDDRVVLGTAAFSKGAHYWELHVDRYDNHPDPAFGVARASVVKDMMLGKDDKAWAMYVDNNRSWFMHCNSHTNRTEGGVCKGATVGVLLDLNKHTLTFFINGQQQGPTAFSHVDGVFMPALSLNRNVQVTLHTGLEVPTNLGRPKLSGN", "length": 721, "header": "tr|G3MYU7-1|G3MYU7_BOVIN Computationally mapped isoform of Tripartite motif containing 67 OS=Bos taurus OX=9913 GN=TRIM67 PE=4 SV=3 CANONICAL=A0AAA9SKI6-1" }, "locus": { "chromosome": "28", "start_pos": 3963567, "end_pos": 3905773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063258.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063258.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054736.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054736.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 587, "end_pos": 589, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 693, "end_pos": 695, "annotation": "n_glycosylation_sequon" }, { "start_pos": 705, "end_pos": 707, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 210, "end_pos": 253, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SKI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 587, "end_pos": 778, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SKI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" }, { "id": "PS51262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COS", "eco_id": "ECO_0000259", "start_pos": 446, "end_pos": 504, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SKI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKI6" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 511, "end_pos": 605, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 }, { "start_pos": 525, "end_pos": 527 }, { "start_pos": 576, "end_pos": 578 }, { "start_pos": 587, "end_pos": 589 }, { "start_pos": 625, "end_pos": 627 }, { "start_pos": 693, "end_pos": 695 }, { "start_pos": 705, "end_pos": 707 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKM1-1", "uniprot_ac": "A0AAA9SKM1", "uniprot_id": "A0AAA9SKM1_BOVIN", "mass": { "chemical_mass": 49206.0, "monoisotopic_mass": 49206.0 }, "refseq": { "ac": "XP_015331324", "name": "transducin-like enhancer protein 7 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331324" }, "gene_names": [ { "name": "TLE7", "type": "recommended", "evidence": [ { "id": "A0AAA9SKM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1" } ] }, { "name": "TLE7", "type": "synonym", "evidence": [ { "id": "XP_015331324", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331324" } ] } ], "protein_names": [ { "name": "TLE family member 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SKM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1/entry#names_and_taxonomy" } ] }, { "name": "transducin-like enhancer protein 7 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015331324", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331324" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TLE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1", "locus": { "chromosome": "18", "start_pos": 39643611, "end_pos": 39637109, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060492", "url": "https://www.ensembl.org/id/ENSBTAG00000060492" } ] } } ], "crossref": [ { "id": "A0AAA9SKM1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "505120", "url": "https://www.ncbi.nlm.nih.gov/gene/505120", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505120", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505120", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10814:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10814:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015331324", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331324", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEEKEETLFHVLPIYDEPEKRRDVPESPDASSQPEHHAWSQLGEMCGPPEQPLGSLRQHGPAYQQMTCASPQQQAPQALDGSELPATWLSKAESEDAAFGFSPPPGAEFGEPCPSPGPSEEVLSFLRAIPPVPDDVVVRQRAPHKSWKVGRLRHGKKVYAVAISGSTHHVYTCGHGYIRVWDESALHAWDQAPQAQLNFQDRDSCVFTCKLFPDERSLITGGLSQSLTLWDLVPTPRVRAQLASTGSVCYSLALSSNAQICVASFKGFVEIWDLQNQILIRKHEVPIYGSRCVDITGNKFWTGGEDTKLYSWDLRSYQRLQQHDLRHEILSITHDPSEEWLLVGLRMSDIVIVHTHRKEKFKAVLQKYAYHHNLKFASCGSFLVATMNETIRCIAAPSLHKLFQVEESAHILCCDISSDNQYVVTGSKNSASVYQLLY", "length": 439, "header": "tr|A0AAA9SKM1-1|A0AAA9SKM1_BOVIN Isoform 1 of TLE family member 7 OS=Bos taurus OX=9913 GN=TLE7 PE=3 SV=1 CANONICAL=A0AAA9SKM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1/entry#A0AAA9SKM1-1", "sequence": { "sequence": "MSEEKEETLFHVLPIYDEPEKRRDVPESPDASSQPEHHAWSQLGEMCGPPEQPLGSLRQHGPAYQQMTCASPQQQAPQALDGSELPATWLSKAESEDAAFGFSPPPGAEFGEPCPSPGPSEEVLSFLRAIPPVPDDVVVRQRAPHKSWKVGRLRHGKKVYAVAISGSTHHVYTCGHGYIRVWDESALHAWDQAPQAQLNFQDRDSCVFTCKLFPDERSLITGGLSQSLTLWDLVPTPRVRAQLASTGSVCYSLALSSNAQICVASFKGFVEIWDLQNQILIRKHEVPIYGSRCVDITGNKFWTGGEDTKLYSWDLRSYQRLQQHDLRHEILSITHDPSEEWLLVGLRMSDIVIVHTHRKEKFKAVLQKYAYHHNLKFASCGSFLVATMNETIRCIAAPSLHKLFQVEESAHILCCDISSDNQYVVTGSKNSASVYQLLY", "length": 439, "header": "tr|A0AAA9SKM1-1|A0AAA9SKM1_BOVIN Isoform 1 of TLE family member 7 OS=Bos taurus OX=9913 GN=TLE7 PE=3 SV=1 CANONICAL=A0AAA9SKM1-1" }, "locus": { "chromosome": "18", "start_pos": 39643353, "end_pos": 39639841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122470.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122470.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086887.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086887.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505120", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505120", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 389, "end_pos": 391 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKM4-1", "uniprot_ac": "A0AAA9SKM4", "uniprot_id": "A0AAA9SKM4_BOVIN", "mass": { "chemical_mass": 35854.0, "monoisotopic_mass": 35854.0 }, "refseq": {}, "gene_names": [ { "name": "LOC782159", "type": "recommended", "evidence": [ { "id": "A0AAA9SKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4" } ] } ], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC782159", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKM4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRRHKSKSHARGKRHQVRGDTQEAQASAAEAPKEECPSSHSTAPQGSLPSSPAAGNHQQLQGAMVPSSPDAGPSCAGSDAGASQAAPRKDLLARKARILVEFLLEKYTKKEPITQNALMKIVSRKYRQHFSEILSTVRERMELVFGLEMKEVDGRGNIYTLIRKLSLGGNDCPRDEGALPKSRLLMVLLGVIFMNGNRATEEKIWEFLSMLGVYAGRRHCIFGEPRRLITKDLVQKEYLNYHRVPNSDPPRYEFLWGPRACVETSKMKVLEALAKFHGRVPSSFPDLYDEALRDQAERAGLRGAAGARSKAEASAPSRASSHI", "length": 324, "header": "tr|A0AAA9SKM4-1|A0AAA9SKM4_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC782159 PE=4 SV=1 CANONICAL=A0AAA9SKM4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4/entry#A0AAA9SKM4-1", "sequence": { "sequence": "MPRRHKSKSHARGKRHQVRGDTQEAQASAAEAPKEECPSSHSTAPQGSLPSSPAAGNHQQLQGAMVPSSPDAGPSCAGSDAGASQAAPRKDLLARKARILVEFLLEKYTKKEPITQNALMKIVSRKYRQHFSEILSTVRERMELVFGLEMKEVDGRGNIYTLIRKLSLGGNDCPRDEGALPKSRLLMVLLGVIFMNGNRATEEKIWEFLSMLGVYAGRRHCIFGEPRRLITKDLVQKEYLNYHRVPNSDPPRYEFLWGPRACVETSKMKVLEALAKFHGRVPSSFPDLYDEALRDQAERAGLRGAAGARSKAEASAPSRASSHI", "length": 324, "header": "tr|A0AAA9SKM4-1|A0AAA9SKM4_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC782159 PE=4 SV=1 CANONICAL=A0AAA9SKM4-1" }, "locus": { "chromosome": "X", "start_pos": 117206139, "end_pos": 117205138, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131682.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131682.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084463.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084463.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM4" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 292, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKN1-1", "uniprot_ac": "A0AAA9SKN1", "uniprot_id": "A0AAA9SKN1_BOVIN", "mass": { "chemical_mass": 47539.0, "monoisotopic_mass": 47539.0 }, "refseq": {}, "gene_names": [ { "name": "ANHX", "type": "recommended", "evidence": [ { "id": "A0AAA9SKN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1" } ] } ], "protein_names": [ { "name": "Anomalous homeobox", "type": "synonym", "evidence": [ { "id": "A0AAA9SKN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANHX", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1", "locus": { "chromosome": "17", "start_pos": 44283769, "end_pos": 44300153, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026626", "url": "https://www.ensembl.org/id/ENSBTAG00000026626" } ] } } ], "crossref": [ { "id": "A0AAA9SKN1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026626", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026626", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10390:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10390:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16878", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16878", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI9", "url": "https://www.uniprot.org/uniprotkb/E1BAI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDPLRVSLALSLLPALPGAWWGGGMGSGPQRKPGSLEGCEVSDLLPVVLGRKRGPTRLAMQSFLQLLRGNEGPSLPLSELVTLAGRLCRDLQDDPTQVQSLVTAVLDSQFRLYLLDNADVALVCASVLAQREQHQAACRLLEGCQVPGGSPKLVQLWNDIHYRLAMKKLGVSTLTPVQKFRCRKRNPPPASLCPNGLKSRNFPREVRQKLEDFASGVSTNPSKAEREGLASETHLTTEQVYNWFANYRRRQRALMQRAAPAQPDSAEDLTSGEASRHLPPQPTDHPQLGSGLVDRPQWSTGPEKSGPLQTLETTQGPWEPVALTPDFSGDETMPKSLAPSIKPQGTYLEEDPGSCGSQAEQQAGNLRVTQPPAQAPDFILNQSSSDLTPAPPGFPGPMSAVELSQPPPSSQVQWSDGQTSSDAFWGARMLLELSAGSLG", "length": 440, "header": "tr|A0AAA9SKN1-1|A0AAA9SKN1_BOVIN Isoform 1 of Anomalous homeobox OS=Bos taurus OX=9913 GN=ANHX PE=4 SV=1 CANONICAL=A0AAA9SKN1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1/entry#A0AAA9SKN1-1", "sequence": { "sequence": "MKDPLRVSLALSLLPALPGAWWGGGMGSGPQRKPGSLEGCEVSDLLPVVLGRKRGPTRLAMQSFLQLLRGNEGPSLPLSELVTLAGRLCRDLQDDPTQVQSLVTAVLDSQFRLYLLDNADVALVCASVLAQREQHQAACRLLEGCQVPGGSPKLVQLWNDIHYRLAMKKLGVSTLTPVQKFRCRKRNPPPASLCPNGLKSRNFPREVRQKLEDFASGVSTNPSKAEREGLASETHLTTEQVYNWFANYRRRQRALMQRAAPAQPDSAEDLTSGEASRHLPPQPTDHPQLGSGLVDRPQWSTGPEKSGPLQTLETTQGPWEPVALTPDFSGDETMPKSLAPSIKPQGTYLEEDPGSCGSQAEQQAGNLRVTQPPAQAPDFILNQSSSDLTPAPPGFPGPMSAVELSQPPPSSQVQWSDGQTSSDAFWGARMLLELSAGSLG", "length": 440, "header": "tr|A0AAA9SKN1-1|A0AAA9SKN1_BOVIN Isoform 1 of Anomalous homeobox OS=Bos taurus OX=9913 GN=ANHX PE=4 SV=1 CANONICAL=A0AAA9SKN1-1" }, "locus": { "chromosome": "17", "start_pos": 44299937, "end_pos": 44284300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098849.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098849.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086899.1" } ] } }, { "isoform_ac": "E1BAI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1/entry#E1BAI9-1", "sequence": { "sequence": "MQSFLQLLRGNEGPSLPLSELVTLAGRLCRDLQDDPTQVQSLVTAVLDSQFRLYLLDNADVALVCASVLAQREQHQAACRLLEGCQVPGGSPKLVQLWNDIHYRLAMKKLGVSTLTPVQKFRCRKRNPPPASLCPNGLKSRNFPREVRQKLEDFASGVSTNPSKAEREGLASETHLTTEQVYNWFANYRRRQRALMQRAAPAPTPDSAEDLTSGEASRHLPPQPTDHPQLGSGLVDRPQWSRFADPPSIKPQGTYLEEDPGSCGSQAEQQAGNLRVTQPPAQAPDFILNQSSSDLTPAPPGFPGPMSAVELSQPPPSSQVQWSDGQTSSDAFWGARMLLELSAGSLG", "length": 347, "header": "tr|E1BAI9-1|E1BAI9_BOVIN Computationally mapped isoform of Anomalous homeobox OS=Bos taurus OX=9913 GN=ANHX PE=4 SV=4 CANONICAL=A0AAA9SKN1-1" }, "locus": { "chromosome": "17", "start_pos": 44298747, "end_pos": 44284300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037916.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037916.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037738.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037738.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKN1" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 255, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 382, "end_pos": 384 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKQ3-1", "uniprot_ac": "A0AAA9SKQ3", "uniprot_id": "A0AAA9SKQ3_BOVIN", "mass": { "chemical_mass": 28423.0, "monoisotopic_mass": 28423.0 }, "refseq": { "ac": "XP_059734475", "name": "dnaJ homolog subfamily C member 8-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734475" }, "gene_names": [ { "name": "LOC512248", "type": "recommended", "evidence": [ { "id": "A0AAA9SKQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3" } ] }, { "name": "LOC512248", "type": "synonym", "evidence": [ { "id": "XP_059734475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734475" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 8", "type": "recommended", "evidence": [ { "id": "A0AAA9SKQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3/entry#names_and_taxonomy" } ] }, { "name": "dnaJ homolog subfamily C member 8-like", "type": "synonym", "evidence": [ { "id": "XP_059734475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734475" } ] } ], "function": [ { "annotation": "Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3#function" }, { "database": "UniProtKB", "id": "ARBA00056329", "url": "https://www.uniprot.org/uniprotkb/ARBA00056329#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC512248", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKQ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512248", "url": "https://www.ncbi.nlm.nih.gov/gene/512248", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512248", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512248", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR15606", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15606", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15606:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15606:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059734475", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPGESGASGGGGGTEEAFMTFYSEVRQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYMEHTVKEQKKQLKKEGKPTNVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRMDSWRNSKPIRKERKRRKTGPF", "length": 241, "header": "tr|A0AAA9SKQ3-1|A0AAA9SKQ3_BOVIN Isoform 1 of DnaJ homolog subfamily C member 8 OS=Bos taurus OX=9913 GN=LOC512248 PE=4 SV=1 CANONICAL=A0AAA9SKQ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3/entry#A0AAA9SKQ3-1", "sequence": { "sequence": "MAAPGESGASGGGGGTEEAFMTFYSEVRQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYMEHTVKEQKKQLKKEGKPTNVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRMDSWRNSKPIRKERKRRKTGPF", "length": 241, "header": "tr|A0AAA9SKQ3-1|A0AAA9SKQ3_BOVIN Isoform 1 of DnaJ homolog subfamily C member 8 OS=Bos taurus OX=9913 GN=LOC512248 PE=4 SV=1 CANONICAL=A0AAA9SKQ3-1" }, "locus": { "chromosome": "19", "start_pos": 27812096, "end_pos": 27811374, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089600.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089600.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086926.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512248", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512248", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ3" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 124, "start_aa": "Asn", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKR2-1", "uniprot_ac": "A0AAA9SKR2", "uniprot_id": "A0AAA9SKR2_BOVIN", "mass": { "chemical_mass": 41133.0, "monoisotopic_mass": 41133.0 }, "refseq": { "ac": "XP_059749004", "name": "actin-like protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749004" }, "gene_names": [ { "name": "ACTL10", "type": "recommended", "evidence": [ { "id": "A0AAA9SKR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2" } ] }, { "name": "ACTL10", "type": "synonym", "evidence": [ { "id": "XP_059749004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749004" } ] } ], "protein_names": [ { "name": "Actin like 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SKR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2/entry#names_and_taxonomy" } ] }, { "name": "actin-like protein 10", "type": "synonym", "evidence": [ { "id": "XP_059749004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749004" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTL10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2", "locus": { "chromosome": "13", "start_pos": 63122409, "end_pos": 63118762, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000067964", "url": "https://www.ensembl.org/id/ENSBTAG00000067964" } ] } } ], "crossref": [ { "id": "A0AAA9SKR2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKR2", "database": "AlphaFoldDB", "categories": [] }, { "id": "132346952", "url": "https://www.ncbi.nlm.nih.gov/gene/132346952", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:132346952", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132346952", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059749004", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059749004", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLSNSRRVRRLSSLGHVAVVVDQGSGFTKAGFAGEEQPRLVLKSSSLVPSWDRPVLPGAPGCELAGGVARAHPIKHGVVVDWEALEGLWERLLVGGLRVCPEEWPVLVSDSPSAPPVGRERVAELLFEALAVPACHLASTALLALCSVGAFSGLALEAGAGVCHATPVYAGHSWHKATFRLDVAGSTLSRYLRDLLVAAGPDHRLQALPHKIITQLKKRCCYVSLDFEGDLCNPARHHPVSFSLGSGCSVCLGRERFCCPEPLFQPGLLGQAEPGLPILAFRALQRVPATLQTRLANTMVLAGGSTLFPGFPERLELELEAQCQRHGCGTLQPHLVAKPGRGTAVWTGGSMVASLRTFQCRWMTRAMYQECGSRLVHEVFH", "length": 383, "header": "tr|A0AAA9SKR2-1|A0AAA9SKR2_BOVIN Isoform 1 of Actin like 10 OS=Bos taurus OX=9913 GN=ACTL10 PE=3 SV=1 CANONICAL=A0AAA9SKR2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2/entry#A0AAA9SKR2-1", "sequence": { "sequence": "MASLSNSRRVRRLSSLGHVAVVVDQGSGFTKAGFAGEEQPRLVLKSSSLVPSWDRPVLPGAPGCELAGGVARAHPIKHGVVVDWEALEGLWERLLVGGLRVCPEEWPVLVSDSPSAPPVGRERVAELLFEALAVPACHLASTALLALCSVGAFSGLALEAGAGVCHATPVYAGHSWHKATFRLDVAGSTLSRYLRDLLVAAGPDHRLQALPHKIITQLKKRCCYVSLDFEGDLCNPARHHPVSFSLGSGCSVCLGRERFCCPEPLFQPGLLGQAEPGLPILAFRALQRVPATLQTRLANTMVLAGGSTLFPGFPERLELELEAQCQRHGCGTLQPHLVAKPGRGTAVWTGGSMVASLRTFQCRWMTRAMYQECGSRLVHEVFH", "length": 383, "header": "tr|A0AAA9SKR2-1|A0AAA9SKR2_BOVIN Isoform 1 of Actin like 10 OS=Bos taurus OX=9913 GN=ACTL10 PE=3 SV=1 CANONICAL=A0AAA9SKR2-1" }, "locus": { "chromosome": "13", "start_pos": 63121343, "end_pos": 63120195, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129417.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129417.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084468.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084468.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132346952", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132346952", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKS6-1", "uniprot_ac": "A0AAA9SKS6", "uniprot_id": "A0AAA9SKS6_BOVIN", "mass": { "chemical_mass": 19582.0, "monoisotopic_mass": 19582.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM52", "type": "recommended", "evidence": [ { "id": "A0AAA9SKS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6" } ] } ], "protein_names": [ { "name": "Transmembrane protein 52", "type": "synonym", "evidence": [ { "id": "A0AAA9SKS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6", "locus": { "chromosome": "16", "start_pos": 50835251, "end_pos": 50833311, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055416", "url": "https://www.ensembl.org/id/ENSBTAG00000055416" } ] } } ], "crossref": [ { "id": "A0AAA9SKS6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR038942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33955", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33955", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33955:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33955:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSRAPADRGLLLLPPLLPLPQVGRGVLGSGTAGRVCVPPSHRCPPQARWSSLWHVGLILLTALLLLLCGVSASCVRFCHLRKRAHSQPHLPPAPEPCDLTAIPMDSDSPAHSTVTSYSSVQCWLGMQLPLPFGELDLDSTTLPAYSLYAPEPPHPSPCNPASPGASCLETPPGLQEPGPNAQDP", "length": 185, "header": "tr|A0AAA9SKS6-1|A0AAA9SKS6_BOVIN Isoform 1 of Transmembrane protein 52 OS=Bos taurus OX=9913 GN=TMEM52 PE=4 SV=2 CANONICAL=A0AAA9SKS6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS6/entry#A0AAA9SKS6-1", "sequence": { "sequence": "MFSRAPADRGLLLLPPLLPLPQVGRGVLGSGTAGRVCVPPSHRCPPQARWSSLWHVGLILLTALLLLLCGVSASCVRFCHLRKRAHSQPHLPPAPEPCDLTAIPMDSDSPAHSTVTSYSSVQCWLGMQLPLPFGELDLDSTTLPAYSLYAPEPPHPSPCNPASPGASCLETPPGLQEPGPNAQDP", "length": 185, "header": "tr|A0AAA9SKS6-1|A0AAA9SKS6_BOVIN Isoform 1 of Transmembrane protein 52 OS=Bos taurus OX=9913 GN=TMEM52 PE=4 SV=2 CANONICAL=A0AAA9SKS6-1" }, "locus": { "chromosome": "16", "start_pos": 50834863, "end_pos": 50833321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124136.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124136.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086953.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086953.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKT0-1", "uniprot_ac": "A0AAA9SKT0", "uniprot_id": "A0AAA9SKT0_BOVIN", "mass": { "chemical_mass": 63407.0, "monoisotopic_mass": 63407.0 }, "refseq": {}, "gene_names": [ { "name": "CD96", "type": "recommended", "evidence": [ { "id": "A0AAA9SKT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0" } ] } ], "protein_names": [ { "name": "CD96 molecule", "type": "synonym", "evidence": [ { "id": "A0AAA9SKT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0", "locus": { "chromosome": "1", "start_pos": 56402835, "end_pos": 56306243, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014441", "url": "https://www.ensembl.org/id/ENSBTAG00000014441" } ] } } ], "crossref": [ { "id": "A0AAA9SKT0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014441", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014441", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QHGFYCA", "url": "https://omabrowser.org/oma/group/QHGFYCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N360", "url": "https://www.orthodb.org/?gene=F1N360", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15317:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15317:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SKT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N360", "url": "https://www.uniprot.org/uniprotkb/F1N360", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N360-1", "url": "https://www.uniprot.org/uniprotkb/F1N360-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKKWTYCAVYSIIQMHLVRGIVEETFGAEEHIYALPGSDVNLTCQTQKKGILVQMQWSKVTDKVDLLAVYHPQHGFYCDSKSACRSLVAFREPPGNVFEWTLYLRNVSSSTTGKYECSFTLYPEGIQTKIYSLKIQTNVAQEEWKNNHTIEIEINGTLEIPCFQNTSLEISSVLTFAWLVEDNGTQKTLTAGGHPISNSALFKDRVRIGTDYRLYLSPVQIHDDGWKFSCHVVVRPGRVLRSSTTVKVFAKPEIPMIVENNSMDVIGERIFTCSLRNVFPTANLTWFIQRSFPQGEREEMYTTSEKRKNKDGFWELKSVLTSVYDNKPAHSNNLTIWCMALSPAPGHKVWNSSSEKITFFLGSLNPPIDSPLNATESTLGTRPSLANSISPTGYRTPSSTAHVDVSTSTSNVIPPSVQTSNSDVPTRGFNYSWTSSGKDAKHSAPWMPSETNSSPSSGAGSTLPGDIFTSTTRASSEVPTTANVSTKNNHITGTVISKPKDGMSWPVIVAALLLSCFVLFGLGVRKWCQYQKEIMQRPPPFKPPPPPIKYTCIQESIGSDLPCHELETL", "length": 570, "header": "tr|A0AAA9SKT0-1|A0AAA9SKT0_BOVIN Isoform 1 of CD96 molecule OS=Bos taurus OX=9913 GN=CD96 PE=4 SV=1 CANONICAL=A0AAA9SKT0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0/entry#A0AAA9SKT0-1", "sequence": { "sequence": "MEKKWTYCAVYSIIQMHLVRGIVEETFGAEEHIYALPGSDVNLTCQTQKKGILVQMQWSKVTDKVDLLAVYHPQHGFYCDSKSACRSLVAFREPPGNVFEWTLYLRNVSSSTTGKYECSFTLYPEGIQTKIYSLKIQTNVAQEEWKNNHTIEIEINGTLEIPCFQNTSLEISSVLTFAWLVEDNGTQKTLTAGGHPISNSALFKDRVRIGTDYRLYLSPVQIHDDGWKFSCHVVVRPGRVLRSSTTVKVFAKPEIPMIVENNSMDVIGERIFTCSLRNVFPTANLTWFIQRSFPQGEREEMYTTSEKRKNKDGFWELKSVLTSVYDNKPAHSNNLTIWCMALSPAPGHKVWNSSSEKITFFLGSLNPPIDSPLNATESTLGTRPSLANSISPTGYRTPSSTAHVDVSTSTSNVIPPSVQTSNSDVPTRGFNYSWTSSGKDAKHSAPWMPSETNSSPSSGAGSTLPGDIFTSTTRASSEVPTTANVSTKNNHITGTVISKPKDGMSWPVIVAALLLSCFVLFGLGVRKWCQYQKEIMQRPPPFKPPPPPIKYTCIQESIGSDLPCHELETL", "length": 570, "header": "tr|A0AAA9SKT0-1|A0AAA9SKT0_BOVIN Isoform 1 of CD96 molecule OS=Bos taurus OX=9913 GN=CD96 PE=4 SV=1 CANONICAL=A0AAA9SKT0-1" }, "locus": { "chromosome": "1", "start_pos": 56402556, "end_pos": 56306274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123858.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123858.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083235.1" } ] } }, { "isoform_ac": "F1N360-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0/entry#F1N360-1", "sequence": { "sequence": "MEKKWTYCAVYSIIQMHLVRGIVEETFGAEEHIYALPGSDVNLTCQTQKKGILVQMQWSKVTDKVDLLAVYHPQHGFYCDSKSACRSLVAFREPPGNVFEWTLYLRNVSSSTTGKYECSFTLYPEGIQTKIYSLKIQTNVAQEEWKNNHTIEIEINGTLEIPCFQNTSLEISSVLTFAWLVEDNGTQKTLTAGGHPISNSALFKDRVRIGTDYRLYLSPVQIHDDGWKFSCHVVVRPGRVLRSSTTVKVFAKPEIPMIVENNSMDVIGERIFTCSLRNVFPTANLTWFIQRSFPQGEREEMYTTSEKRKNKDGFWELKSVLTSVYDNKPAHSNNLTIWCMALSPAPGHKVWNSSSEKITFFLGSLNPPIDSPLNATESTLGTRPSLANSISPTGYRTPSSTAHVDVSTSTSNVIPPSVQTSNSDVPTRGFNYSWTSSGKDAKHSAPWMPSETNSSPSSGAGSTLPGDIFTSTTRASSEVPTTANVSTKNNHITGTVISKPKDGMSWPVIVAALLLSCFVLFGLGVRKWCQYQKEIDDSKSVP", "length": 542, "header": "tr|F1N360-1|F1N360_BOVIN Computationally mapped isoform of CD96 molecule OS=Bos taurus OX=9913 GN=CD96 PE=4 SV=2 CANONICAL=A0AAA9SKT0-1" }, "locus": { "chromosome": "1", "start_pos": 56401850, "end_pos": 56306274, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019209.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019209.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019209.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019209.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZIM2-1", "protein_name": "CD96 molecule", "gene_name": "CD96", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKIWTYYVVCTIIQIHFVRGVLEGSSNAEEDIYVLPGSDVNLTCQAHTKSFLVQIQWSRLTDKVDLIALYHPTHGFYCANQSPCESLVAFRETPENVSEWTLHLRNISSSVTGKYKCSFTLYPEGIHTKIYNLFLQADVTQDEWRSSRTIEIEINRTLEIPCFQNISLEISPKLNFSWLVEGNGTQETLITQDHPISSSTFFKDRVKLGTNYTLHLSPVQIHDDDQKFSCHIVVRPGKILASSTTVKVFAKPEIPMIVENNSMDVLGKRIFTCLLKNVFPTANLTWFIERNFPQGERKEIYIANEERKDKGGFLELKSVLTSLYDNKPAQSDNLTIWCMALSPVPGNKVWNNSSEKITFSLGSVNPPTEPLLSASEVTLGIHPSPAHSTSPASYAAPPSTAFVDVSTSTPEVTPQSAQTSDSTVTTRGFNYSQTSSGKDPKYSSWMPSETYSPSSLGASSTIHGDIFTNTTVAFSEVPTTANGSTENNHMHIPGIVVNKPKDGMSWPVIVAALLFSCLVLFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYVCIQEPIESDLPCHEMETL", "length": 571 }, "evidence": [ { "id": "A0AAA9SKT0", "url": "https://omabrowser.org/oma/group/A0AAA9SKT0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P40200-1", "protein_name": "T-cell surface protein tactile", "gene_name": "CD96", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKKWKYCAVYYIIQIHFVKGVWEKTVNTEENVYATLGSDVNLTCQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSKWTLHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLEIPCFQNSSSKISSEFTYAWSVENSSTDSWVLLSKGIKEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLSPVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDNLTIWCMALSPVPGNKVWNISSEKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSPARYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETYSSSPSGAGSTLHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGMSWPVIVAALLFCCMILFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYTCIQEPNESDLPYHEMETL", "length": 585 }, "evidence": [ { "id": "A0AAA9SKT0", "url": "https://omabrowser.org/oma/group/A0AAA9SKT0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3U0X8-1", "protein_name": "T-cell surface protein tactile", "gene_name": "Cd96", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRKWTYCVVYTIIQIQFFRGVWEELFNVGDDVYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPYTQDEHNYTIEIETNRTLEIPCFQNTSSEIPPRFTFSWLVEKDGVEEVLFTHHHHVNNSTSFKGRIRLGGDYRLHLSPVQIQDDGRTFSCHLTVNPLKAWKMSTTVKVFAKPEILMTVENSTMDVLGERVFTCLLKNVFPKANITWFIDGRFLQGNEEGIYITNEEKNCSSGFWELKSVLTRMHSGPSQSNNMTAWCMALSPGPRNKMWNTSSQPITVSFDSVIAPTKHLPTVTGSTLGTQPFSDAGVSPTGYLATPSVTIVDENGLTPDATPQTSNSSMTTKDGNYLEASSGTDAKNSSRAAASSKSGSWPFPFTSPPEWHSLPGTSTGPQEPDSPVSWIPSEVHTSAPLDASLAPHDTIISTTTEFPNVLTTANGTTKIDHGPITSIIVNQPSDGMSWPVLVAALLFFCTLLFGLGVRKWYRYQNEIMERPPPFKPPPPPIKYTYIQEPIGCDLCCHEMEVL", "length": 602 }, "evidence": [ { "id": "A0AAA9SKT0", "url": "https://omabrowser.org/oma/group/A0AAA9SKT0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5BK49-1", "protein_name": "T-cell surface protein tactile", "gene_name": "Cd96", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRKWTYCVVYAIIQIQFFRGAWEELFNAGDNNVYALPGSDVNLTCQTMEKDLMVQMQWSKVTDEIDMIVVYHPQYGFHYMQGVACESRVAAVETLKDATKWTLNLRNISSSLSGKYECSFTMYPTGTKTIVYNLIVEPYTQDEHNRTIEIETNRTLEIPCFQNTSSEISPRFTFSWLVEKDGVEDVLFTYDYHVSNSTAFKGRVGLGADYGLRLSPVQIQDDGRTFSCFLRISPLKVWKTSTTVKVFAKPEILMTVENTTMDVLGERVFTCLLKNVFPKASITWLIDGRLFQGNEEGIYITNEEKNSSSGFWELKSVLTRMHNRTSQSNNMTVWCMALSPGPGNKMWNTSSQPITFSLDSGTAPTKRLPNVTGSTLGAQTFPDAEVSPTRYLATSSMTIVDENVLTPDPTPQTSNSSMTTKDVNYSQPSSGTDAKNSSRAASSSDGGSRPFPSTSPPKWLSLPHTSTGPQEPDSAVSWIPTDAYTSGSSDASLTSHDVIIRTTKEFPDVLTTANGTTKIKHGHVTGITVNKPRDGMSWPVAVATLLFFCILLFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYMCIQEPTGRGMPCHEMEVL", "length": 603 }, "evidence": [ { "id": "A0AAA9SKT0", "url": "https://omabrowser.org/oma/group/A0AAA9SKT0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT0" }, { "id": "SM00409", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00409" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 137, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 484, "end_pos": 486 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKU2-1", "uniprot_ac": "A0AAA9SKU2", "uniprot_id": "A0AAA9SKU2_BOVIN", "mass": { "chemical_mass": 44283.0, "monoisotopic_mass": 44283.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "LysM domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKU2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR036779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20932:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20932:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SKU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RRGLKGNRPWENTHQSPPPLVFWFSPPRPPVVATATKQLLYSLQRAGEAASDALLSAYFEHIELTPIVSFPLERHQDCESQKSKTLSSRLRHSFQATVAGVGRLRSFRSLSGWPPDFRGCGSTNALRDPGSQLLAGRGGLHFLWFPVTSPARGLLGNEVFFSKSLPPGWIQALSSWQTRGVWNDKNLDVEPEFEGVTDLVWRIPLRISEGERVLQTLAIVTPFACSHSPHRMEQIKRANRLYTNDSIFLKKTLYIPILTEPRDLFNGLDSEEEKDGEEAVQPSKDEVRPHSAERKKRERGLGHANGEPLPTAGQEPARHDLSASDFLKKLDSQISLSKKAAAQKLKKGESGIPGEDSSLHLSSPRMQQRAVLGPVPLTQTSRTRTLRDQEDEIFKL", "length": 396, "header": "tr|A0AAA9SKU2-1|A0AAA9SKU2_BOVIN Isoform 1 of LysM domain containing 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SKU2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKU2/entry#A0AAA9SKU2-1", "sequence": { "sequence": "RRGLKGNRPWENTHQSPPPLVFWFSPPRPPVVATATKQLLYSLQRAGEAASDALLSAYFEHIELTPIVSFPLERHQDCESQKSKTLSSRLRHSFQATVAGVGRLRSFRSLSGWPPDFRGCGSTNALRDPGSQLLAGRGGLHFLWFPVTSPARGLLGNEVFFSKSLPPGWIQALSSWQTRGVWNDKNLDVEPEFEGVTDLVWRIPLRISEGERVLQTLAIVTPFACSHSPHRMEQIKRANRLYTNDSIFLKKTLYIPILTEPRDLFNGLDSEEEKDGEEAVQPSKDEVRPHSAERKKRERGLGHANGEPLPTAGQEPARHDLSASDFLKKLDSQISLSKKAAAQKLKKGESGIPGEDSSLHLSSPRMQQRAVLGPVPLTQTSRTRTLRDQEDEIFKL", "length": 396, "header": "tr|A0AAA9SKU2-1|A0AAA9SKU2_BOVIN Isoform 1 of LysM domain containing 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SKU2-1" }, "locus": { "chromosome": "3", "start_pos": 19652846, "end_pos": 19644695, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096736.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096736.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086976.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086976.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 244, "end_pos": 246 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKV1-1", "uniprot_ac": "A0AAA9SKV1", "uniprot_id": "A0AAA9SKV1_BOVIN", "mass": { "chemical_mass": 19278.0, "monoisotopic_mass": 19278.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SKV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SKV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19339:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19339:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SKV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKLLALSLVILWLQLAKVNNQQGKQKLQTLSIQEGENVTMNCSYKSITLPALQWYRQDSRRGFVHLILMRSNERQKHSGRLHFTLDNSIKSSSLSIMASQAEDTATYLCAPDTQCSAGIRSPSANLPELSLRSRDSVQSWWFCLPTKESLQTASNTKGSSSQIPEFLVACL", "length": 172, "header": "tr|A0AAA9SKV1-1|A0AAA9SKV1_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SKV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1/entry#A0AAA9SKV1-1", "sequence": { "sequence": "MEKLLALSLVILWLQLAKVNNQQGKQKLQTLSIQEGENVTMNCSYKSITLPALQWYRQDSRRGFVHLILMRSNERQKHSGRLHFTLDNSIKSSSLSIMASQAEDTATYLCAPDTQCSAGIRSPSANLPELSLRSRDSVQSWWFCLPTKESLQTASNTKGSSSQIPEFLVACL", "length": 172, "header": "tr|A0AAA9SKV1-1|A0AAA9SKV1_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SKV1-1" }, "locus": { "chromosome": "10", "start_pos": 23273075, "end_pos": 23272148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129576.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129576.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084537.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084537.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 128, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 }, { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKY4-1", "uniprot_ac": "A0AAA9SKY4", "uniprot_id": "A0AAA9SKY4_BOVIN", "mass": { "chemical_mass": 146114.0, "monoisotopic_mass": 146114.0 }, "refseq": {}, "gene_names": [ { "name": "SPAG5", "type": "recommended", "evidence": [ { "id": "A0AAA9SKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ] } ], "protein_names": [ { "name": "Sperm associated antigen 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPAG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4", "locus": { "chromosome": "19", "start_pos": 20034503, "end_pos": 20053770, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013100", "url": "https://www.ensembl.org/id/ENSBTAG00000013100" } ] } } ], "crossref": [ { "id": "ENSBTAG00000013100", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504585", "url": "https://www.ncbi.nlm.nih.gov/gene/504585", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJ22", "url": "https://www.orthodb.org/?gene=E1BJ22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15347", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15347", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15347:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15347:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ22", "url": "https://www.uniprot.org/uniprotkb/E1BJ22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJ22-1", "url": "https://www.uniprot.org/uniprotkb/E1BJ22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSSTVQLPITLSEVRPKDWPWALSAPLPPPASRVDAGDQTAGHTRARAPTVGMAGRGQSKPRPCPPGPSPERTRPPDALRLRSQSGSAKQVQIKAAGRHGVVSYVWEVFIPRSVSKMWRMKKLNLSLSPSPQPGKAAMRTPLRELALQPDAPTNSGKGPPHSPTPSPCKLGLQEGSNNSSPPDFVNARKTDSPSEQFGHPSKWLEAYQHESDEQPLNLIPQTNSTPKTCEKGVDPRDNNVVKTMVLVPSPGRQQQDITLADRLDSMAEGNSFSLDEPLRPGDLLRKGVDFCMEDSFSETVPGMPEIPAFQDPPSQLLESPPNPCSEQQLHCSKESLKDRSTEAEPEDLVPSESNALLPSSLLWLSPSTALAADCPVSHVDPEGDILEHRAIEERKMSFPTLPEEAELGHQALVSNTDDIPSTCPSPNPGEMESQVVPGPAGKDASGIPGSDVGPWMSPLAWLEKGVNTSVMLENLRQSLSLPSAFQNAAIGTTPFSACSVGTWFTPPAQQERSTNTSQTGLVGTKDSASETEHLLWGRSPDLTALSRHDLEDNLLNSLVILEVLSRQLRDWKSQQSGPHPEVRDSSTQTDTLPNEMSKKPQHLQESQEVGQALQQARNVMQSWVLLSRELISLLHLSLLHLDEDKTALSQETRRAETLVSCCFDVLKKLKARLQSLKAEREEAKHREELALRGKDVAETVLEVFCAHASQRISQLQQDLASMGKFRGLLKETQTQLVGLHTEQEELAQQTASLTSALQQDWIAMQLDYVTWTALLSRFRQLTEKFTAKSRQTLQERDAAIEEKQQVSRELEQVSSHLEDCKSQLERLELENSRLAADLQAQLQILASTESQLKVLQSQHAHCTQDLAMKDELLCRLTQNSEEQTAQWQKEEMALKHVQAKLQQQQAVLAKEVQDLKETLEFAEQENQVAHLELGQVECQLKTTLEVLRERSMQCEGLKDTVENLKVKLASIVAETRQQDLEKMRQYSQELGVLTEQLHSLTLFLQTKLKEKAEPETLPISTASAFSQEHPPPSDSTFLGSPQTAEADEDPESTPVPLLGSDKSAFTRVASTVSLEPTETPGIEKSLAEMGTKTLELQSLCSLLQESKEEAVRILQQKICDLQAQLQAQEEQHQEAQKAKEADIEKLNQTLCLRYKNEKELQEVIQQQNEKILEQIDKSGELIRLREEVTQLTRSLRRAETETKVLQETLAGQQNPDCQPMDTNWIQEKVWLSQEVDKLRVMFLEMKNEKAKLMVKFQSHRNILEENLRRSDEELKKLDDTVQHIYETLLSIPDVVNGCKELQGLLQFLS", "length": 1310, "header": "tr|A0AAA9SKY4-1|A0AAA9SKY4_BOVIN Isoform 1 of Sperm associated antigen 5 OS=Bos taurus OX=9913 GN=SPAG5 PE=4 SV=1 CANONICAL=A0AAA9SKY4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4/entry#A0AAA9SKY4-1", "sequence": { "sequence": "MDSSTVQLPITLSEVRPKDWPWALSAPLPPPASRVDAGDQTAGHTRARAPTVGMAGRGQSKPRPCPPGPSPERTRPPDALRLRSQSGSAKQVQIKAAGRHGVVSYVWEVFIPRSVSKMWRMKKLNLSLSPSPQPGKAAMRTPLRELALQPDAPTNSGKGPPHSPTPSPCKLGLQEGSNNSSPPDFVNARKTDSPSEQFGHPSKWLEAYQHESDEQPLNLIPQTNSTPKTCEKGVDPRDNNVVKTMVLVPSPGRQQQDITLADRLDSMAEGNSFSLDEPLRPGDLLRKGVDFCMEDSFSETVPGMPEIPAFQDPPSQLLESPPNPCSEQQLHCSKESLKDRSTEAEPEDLVPSESNALLPSSLLWLSPSTALAADCPVSHVDPEGDILEHRAIEERKMSFPTLPEEAELGHQALVSNTDDIPSTCPSPNPGEMESQVVPGPAGKDASGIPGSDVGPWMSPLAWLEKGVNTSVMLENLRQSLSLPSAFQNAAIGTTPFSACSVGTWFTPPAQQERSTNTSQTGLVGTKDSASETEHLLWGRSPDLTALSRHDLEDNLLNSLVILEVLSRQLRDWKSQQSGPHPEVRDSSTQTDTLPNEMSKKPQHLQESQEVGQALQQARNVMQSWVLLSRELISLLHLSLLHLDEDKTALSQETRRAETLVSCCFDVLKKLKARLQSLKAEREEAKHREELALRGKDVAETVLEVFCAHASQRISQLQQDLASMGKFRGLLKETQTQLVGLHTEQEELAQQTASLTSALQQDWIAMQLDYVTWTALLSRFRQLTEKFTAKSRQTLQERDAAIEEKQQVSRELEQVSSHLEDCKSQLERLELENSRLAADLQAQLQILASTESQLKVLQSQHAHCTQDLAMKDELLCRLTQNSEEQTAQWQKEEMALKHVQAKLQQQQAVLAKEVQDLKETLEFAEQENQVAHLELGQVECQLKTTLEVLRERSMQCEGLKDTVENLKVKLASIVAETRQQDLEKMRQYSQELGVLTEQLHSLTLFLQTKLKEKAEPETLPISTASAFSQEHPPPSDSTFLGSPQTAEADEDPESTPVPLLGSDKSAFTRVASTVSLEPTETPGIEKSLAEMGTKTLELQSLCSLLQESKEEAVRILQQKICDLQAQLQAQEEQHQEAQKAKEADIEKLNQTLCLRYKNEKELQEVIQQQNEKILEQIDKSGELIRLREEVTQLTRSLRRAETETKVLQETLAGQQNPDCQPMDTNWIQEKVWLSQEVDKLRVMFLEMKNEKAKLMVKFQSHRNILEENLRRSDEELKKLDDTVQHIYETLLSIPDVVNGCKELQGLLQFLS", "length": 1310, "header": "tr|A0AAA9SKY4-1|A0AAA9SKY4_BOVIN Isoform 1 of Sperm associated antigen 5 OS=Bos taurus OX=9913 GN=SPAG5 PE=4 SV=1 CANONICAL=A0AAA9SKY4-1" }, "locus": { "chromosome": "19", "start_pos": 20053770, "end_pos": 20034624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095531.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095531.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084567.1" } ] } }, { "isoform_ac": "E1BJ22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4/entry#E1BJ22-1", "sequence": { "sequence": "MWRMKKLNLSLSPSPQPGKAAMRTPLRELALQPDAPTNSGKGPPHSPTPSPCKLGLQEGSNNSSPPDFVNARKTDSPSEQFGHPSKWLEAYQHESDEQPLNLIPQTNSTPKTCEKGVDPRDNNVVKTMVLVPSPGRQQQDITLADRLDSMAEGNSFSLDEPLRPGDLLRKGVDFCMEDSFSETVPGMPEIPAFQDPPSQLLESPPNPCSEQQLHCSKESLKDRSTEAEPEDLVPSESNALLPSSLLWLSPSTALAADCPVSHVDPEGDILEHRAIEERKMSFPTLPEEAELGHQALVSNTDDIPSTCPSPNPGEMESQVVPGPAGKDASGIPGSDVGPWMSPLAWLEKGVNTSVMLENLRQSLSLPSAFQNAAIGTTPFSACSVGTWFTPPAQQERSTNTSQTGLVGTKDSASETEHLLWGRSPDLTALSRHDLEDNLLNSLVILEVLSRQLRDWKSQQSGPHPEVRDSSTQTDTLPNEMSKKPQHLQESQEVGQALQQARNVMQSWVLLSRELISLLHLSLLHLDEDKTALSQETRRAETLVSCCFDVLKKLKARLQSLKAEREEAKHREELALRGKDVAETVLEVFCAHASQRISQLQQDLASMGKFRGLLKETQTQLVGLHTEQEELAQQTASLTSALQQDWIAMQLDVSRELEQVSSHLEDCKSQLERLELENSRLAADLQAQLQILASTESQLKVLQSQHAHCTQDLAMKDELLCRLTQNSEEQTAQWQKEEMALKHVQAKLQQQQAVLAKEVQDLKETLEFAEQENQVAHLELGQVECQLKTTLEVLRERSMQCEGLKDTVENLKVKLASIVAETRQQDLEKMRQYSQELGVLTEQLHSLTLFLQTKLKEKAEPETLPISTASAFSQEHPPPSDSTFLGSPQTAEADEDPESTPVPLLGSDKSAFTRVASTVSLEPTETPGIEKSLAEMGTKTLELQSLCSLLQESKEEAVRILQQKICDLQAQLQAQEEQHQEAQKAKEADIEKLNQTLCLRYKNEKELQEVIQQQNEKILEQIDKSGELIRLREEVTQLTRSLRRAETETKVLQETLAGQQNPDCQPMDTNWIQEKVWLSQEVDKLRVMFLEMKNEKAKLMVKFQSHRNILEENLRRSDEELKKLDDTVQHIYETLLSIPDVVNGCKELQGLLQFLS", "length": 1155, "header": "tr|E1BJ22-1|A0AAA9SKY4_BOVIN Computationally mapped isoform of Sperm associated antigen 5 OS=Bos taurus OX=9913 GN=SPAG5 PE=4 SV=4 CANONICAL=A0AAA9SKY4-1" }, "locus": { "chromosome": "19", "start_pos": 20053419, "end_pos": 20034624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017417.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017417.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017417.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017417.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 165, "start_aa": "Thr", "end_pos": 165, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr165", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of metaphase plate congression", "id": "GO:0090235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "positive regulation of spindle assembly", "id": "GO:1905832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905832", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "regulation of attachment of spindle microtubules to kinetochore", "id": "GO:0051988", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051988", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "spindle organization", "id": "GO:0007051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "protein localization to centrosome", "id": "GO:0071539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "mitotic sister chromatid segregation", "id": "GO:0000070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "positive regulation of intracellular transport", "id": "GO:0032388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032388", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "ciliary rootlet", "id": "GO:0035253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035253", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" }, { "name": "microtubule plus-end", "id": "GO:0035371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035371", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1148, "end_pos": 1150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 165 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1148, "end_pos": 1150 }, { "start_pos": 125, "end_pos": 127 }, { "start_pos": 178, "end_pos": 180 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 468, "end_pos": 470 }, { "start_pos": 516, "end_pos": 518 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKY7-1", "uniprot_ac": "A0AAA9SKY7", "uniprot_id": "A0AAA9SKY7_BOVIN", "mass": { "chemical_mass": 47292.0, "monoisotopic_mass": 47292.0 }, "refseq": { "ac": "XP_005223586", "name": "trem-like transcript 2 protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223586" }, "gene_names": [ { "name": "TREML2", "type": "recommended", "evidence": [ { "id": "A0AAA9SKY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" } ] }, { "name": "TREML2", "type": "synonym", "evidence": [ { "id": "XP_005223586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223586" } ] } ], "protein_names": [ { "name": "Trem-like transcript 2 protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SKY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7/entry#names_and_taxonomy" } ] }, { "name": "Triggering receptor expressed on myeloid cells-like protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SKY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7/entry#names_and_taxonomy" } ] }, { "name": "trem-like transcript 2 protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223586" } ] } ], "function": [ { "annotation": "Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7#function" }, { "database": "UniProtKB", "id": "ARBA00059754", "url": "https://www.uniprot.org/uniprotkb/ARBA00059754#function" }, { "database": "UniProtKB", "id": "F1MNL2", "url": "https://www.uniprot.org/uniprotkb/F1MNL2#function" }, { "database": "UniProtKB", "id": "G3N1M7", "url": "https://www.uniprot.org/uniprotkb/G3N1M7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TREML2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7", "locus": { "chromosome": "23", "start_pos": 15113778, "end_pos": 15127299, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015707", "url": "https://www.ensembl.org/id/ENSBTAG00000015707" } ] } } ], "crossref": [ { "id": "A0AAA9SKY7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015707", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015707", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515548", "url": "https://www.ncbi.nlm.nih.gov/gene/515548", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515548", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515548", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPLMGFQ", "url": "https://omabrowser.org/oma/group/YPLMGFQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MNL2", "url": "https://www.orthodb.org/?gene=F1MNL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N1M7", "url": "https://www.orthodb.org/?gene=G3N1M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16423:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16423:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005223586", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223586", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNL2", "url": "https://www.uniprot.org/uniprotkb/F1MNL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1M7", "url": "https://www.uniprot.org/uniprotkb/G3N1M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1M7-1", "url": "https://www.uniprot.org/uniprotkb/G3N1M7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPAFLLLLLLLLWLQGPVSGAPTEHVYSKLQHFEGETLSVQCSYKSRKNHLEGKVWCKIRRRKCETGFTRVGVQGPRYLLQDDTQAKVVNITMAALRLQDSGRYWCMRNSSGILYPLMGFLLEVSPASITKGNTPLTKLPSIFQSETVVATGPAPTSGPGSPFISRGTVFTAGLLTLARPLPSPTSRSTRLTSVMGSSFSSTSLSTTGPGRATGSQTATVSPSNTRASAAALGYTSTKATHLCTVGAPTMGMCPTSRTLLNHLFPSRYLEFYPMVLVGVLALLPMLVMLIVVYGFWKKRHMGSYSVCRDPARSCKDSPARPEPPWRSAWSEATQLWGGEELLPEGPRETPRRLLRGGVKTGTCLGWSRAGGEDCATWTQVFLEPEAVPHLLGSPGLLGTWRGWESEHVALGRKSLRVWGATEMVLLGATDPRGPS", "length": 436, "header": "tr|A0AAA9SKY7-1|A0AAA9SKY7_BOVIN Isoform 1 of Trem-like transcript 2 protein OS=Bos taurus OX=9913 GN=TREML2 PE=4 SV=1 CANONICAL=A0AAA9SKY7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7/entry#A0AAA9SKY7-1", "sequence": { "sequence": "MPPAFLLLLLLLLWLQGPVSGAPTEHVYSKLQHFEGETLSVQCSYKSRKNHLEGKVWCKIRRRKCETGFTRVGVQGPRYLLQDDTQAKVVNITMAALRLQDSGRYWCMRNSSGILYPLMGFLLEVSPASITKGNTPLTKLPSIFQSETVVATGPAPTSGPGSPFISRGTVFTAGLLTLARPLPSPTSRSTRLTSVMGSSFSSTSLSTTGPGRATGSQTATVSPSNTRASAAALGYTSTKATHLCTVGAPTMGMCPTSRTLLNHLFPSRYLEFYPMVLVGVLALLPMLVMLIVVYGFWKKRHMGSYSVCRDPARSCKDSPARPEPPWRSAWSEATQLWGGEELLPEGPRETPRRLLRGGVKTGTCLGWSRAGGEDCATWTQVFLEPEAVPHLLGSPGLLGTWRGWESEHVALGRKSLRVWGATEMVLLGATDPRGPS", "length": 436, "header": "tr|A0AAA9SKY7-1|A0AAA9SKY7_BOVIN Isoform 1 of Trem-like transcript 2 protein OS=Bos taurus OX=9913 GN=TREML2 PE=4 SV=1 CANONICAL=A0AAA9SKY7-1" }, "locus": { "chromosome": "23", "start_pos": 15125755, "end_pos": 15118377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127902.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127902.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087029.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087029.1" } ] } }, { "isoform_ac": "F1MNL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7/entry#F1MNL2-1", "sequence": { "sequence": "MPPAFLLLLLLLLWLQGPVSGAPTEHVYSKLQHFEGETLSVQCSYKSRKNHLEGKVWCKIRRRKCETGFTRVGVQGPRYLLQDDTQAKVVNITMAALRLQDSGRYWCMRNSSGILYPLMGFLLEVSPASITKGNTPLTKLPSIFQSETVVATGPAPTSGPGSPFISRGTVFTAGLLTLARPLPSPTSRSTRLTSVMGSSFSSTSLSTTGPGRATGSQTATVSPSNTRASAAALGYTSTKATHLCTVGAPTMGMCPTSRTLLNHLFPSRYLEFYPMVLVGVLALLPMLVMLIVVYGFWKKRHMGSYKQHSHPEAKAIPGGPVVKNLHFHHRGKELRSCMMRGSAKKKKKKEG", "length": 351, "header": "tr|F1MNL2-1|A0AAA9SKY7_BOVIN Computationally mapped isoform of Trem-like transcript 2 protein OS=Bos taurus OX=9913 GN=TREML2 PE=4 SV=4 CANONICAL=A0AAA9SKY7-1" }, "locus": { "chromosome": "23", "start_pos": 15125755, "end_pos": 15114643, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020853.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020853.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020853.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020853.7" } ] } }, { "isoform_ac": "G3N1M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7/entry#G3N1M7-1", "sequence": { "sequence": "MPPAFLLLLLLLLWLQGPVSGAPTEHVYSKLQHFEGETLSVQCSYKSRKNHLEGKVWCKIRRRKCETGFTRVGVQGPRYLLQDDTQAKVVNITMAALRLQDSGRYWCMRNSSGILYPLMGFLLEVSPASITKGNTPLTKLPSIFQSETVVATGPAPTSGPGSPFISRGTVFTAGLLTLARPLPSPTSRSTRLTSVMGSSFSSTSLSTTGPGRATGSQTATVSPSNTRASAAALGYTSTKATHLCTVGAPTMGMCPTSRTLLNHLFPSRYLEFYPMVLVGVLALLPMLVMLIVVYGFWKKRHMGSYSVCRDPARSCKDSPARPEPPWRL", "length": 328, "header": "tr|G3N1M7-1|G3N1M7_BOVIN Computationally mapped isoform of Trem-like transcript 2 protein OS=Bos taurus OX=9913 GN=TREML2 PE=4 SV=3 CANONICAL=A0AAA9SKY7-1" }, "locus": { "chromosome": "23", "start_pos": 15125755, "end_pos": 15114782, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063758.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063758.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055776.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055776.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 157, "start_aa": "Thr", "end_pos": 157, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr157", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515548", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515548", "resource": "KEGG Pathway" }, { "id": "R-BTA-198933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZF32-1", "protein_name": "Trem-like transcript 2 protein", "gene_name": "Treml2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPWPLTFLLFLLLLLWLQGCDSGSSSEKLYRKVQRREGETLSVQCSYKNRRNLVEAKSWCKVKRKKCEHSFTRSWVRGPSYSMRDDTKAKVVRITMEALRVQDSGRYWCMRNTAGNLYPLVGFQLEVYPALTTERNVPPTHLTNTLKDGFANTPMDEFVTTSQVHMSDTGDPFTTNVTVFSSGLHTLASGTTAPTPVTRYSFADTSGTITETERSTESQPATVSPSHTRPFLADSVTTSTMTRHQSSSLSTTGTCHQLTPNRSQETHRPVMVVVLTFLPAPMLLVVAYGFWKKRHMGRYNLDSNYAKSWLHLPEGPETLWKPACSKITQ", "length": 330 }, "evidence": [ { "id": "A0AAA9SKY7", "url": "https://omabrowser.org/oma/group/A0AAA9SKY7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2LA85-1", "protein_name": "Trem-like transcript 2 protein", "gene_name": "Treml2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPWPLTFLLLLLLLLWLQGCVSGHSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPAMVVVLTFLPAPVVLVVAYGFWKKRHMGRYNLGSNYAKPWIHLPEGPETPWKPAWSKITQ", "length": 329 }, "evidence": [ { "id": "A0AAA9SKY7", "url": "https://omabrowser.org/oma/group/A0AAA9SKY7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T2D2-1", "protein_name": "Trem-like transcript 2 protein", "gene_name": "TREML2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPAFLLLLLLWPQGCVSGPSADSVYTKVRLLEGETLSVQCSYKGYKNRVEGKVWCKIRKKKCEPGFARVWVKGPRYLLQDDAQAKVVNITMVALKLQDSGRYWCMRNTSGILYPLMGFQLDVSPAPQTERNIPFTHLDNILKSGTVTTGQAPTSGPDAPFTTGVMVFTPGLITLPRLLASTRPASKTGYSFTATSTTSQGPRRTMGSQTVTASPSNARDSSAGPESISTKSGDLSTRSPTTGLCLTSRSLLNRLPSMPSIRHQDVYSTVLGVVLTLLVLMLIMVYGFWKKRHMASYSMCSDPSTRDPPGRPEPYVEVYLI", "length": 321 }, "evidence": [ { "id": "A0AAA9SKY7", "url": "https://omabrowser.org/oma/group/A0AAA9SKY7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "T cell activation", "id": "GO:0042110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042110", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY7" }, { "id": "PF07686", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin V-set", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 123, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 157 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKZ7-1", "uniprot_ac": "A0AAA9SKZ7", "uniprot_id": "A0AAA9SKZ7_BOVIN", "mass": { "chemical_mass": 113698.0, "monoisotopic_mass": 113698.0 }, "refseq": { "ac": "XP_015328229", "name": "collagen alpha-1(XIX) chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328229" }, "gene_names": [ { "name": "COL19A1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7" } ] }, { "name": "COL19A1", "type": "synonym", "evidence": [ { "id": "XP_015328229", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328229" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(XIX) chain", "type": "recommended", "evidence": [ { "id": "A0AAA9SKZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7/entry#names_and_taxonomy" } ] }, { "name": "Collagen alpha-1(Y) chain", "type": "synonym", "evidence": [ { "id": "A0AAA9SKZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7/entry#names_and_taxonomy" } ] }, { "name": "collagen alpha-1(XIX) chain", "type": "synonym", "evidence": [ { "id": "XP_015328229", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328229" } ] } ], "function": [ { "annotation": "May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7#function" }, { "database": "UniProtKB", "id": "ARBA00055297", "url": "https://www.uniprot.org/uniprotkb/ARBA00055297#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL19A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7", "locus": { "chromosome": "9", "start_pos": 9292837, "end_pos": 8866217, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065931", "url": "https://www.ensembl.org/id/ENSBTAG00000065931" } ] } } ], "crossref": [ { "id": "A0AAA9SKZ7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKZ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "100137749", "url": "https://www.ncbi.nlm.nih.gov/gene/100137749", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100137749", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100137749", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015328229", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328229", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLAGSWRLWLWAAAFLLPASASVMSRDKPENQCPILRTEGRRFRQDNRDKLEVSGFDLAERFSLKHVFCEGDKTCFKLGSSLLIRDTIKIFPKGLPEEFAIAAMFRVRRSAKKERWFLWQVLNQRNMPQVSVIVDGGRKVVELMFQAAEGDVLNYIFKNQELRSLFDRQWHKLGFGIQSQAIALYVDCNLVASRHTDRNGTVDFRGRTVIAARASDGKPVDIELHQLQIYCNWNFIAQETCCEISDIKCPEQPGFGGTAASPAPAHASRMSAFLPAKQELTDQCQCMPHKGEAGSPGQKGEQGENGLRGTPGLPGQKGEQGFEGSKGETGEKGEPGEKGDPGLSGVNGQDGVKGDSGPRGPPGPKGDKGDMGPPGPPTLTGSLGIQGPQGPPGKEGQRGRRGKPGPPGKPGPPGPPGPPGVQGMQQTLDGYYHKGNVGEHGAGGLKGEKGETGSPGFPGSIGPKGEKGESGERFTKGEKGDRGEPGITGSQGIKGEPGDPGPPGVIGSPGLKGQQGPAGSVGPRGPPGDIGLPGEHGIPGKQGNKGEKGDPGGITGPPGLPGPKGEAGPPGKSLPGEPGLDGSPGAPGPRGPKGERGLPGVQGSPGDIGPPGIGIPGRTGSQGPAGEPGIQGPRGLPGLPGTPGTPGNDGAPGRDGKPGLPGPPGDPIALPLLGDIGALFKNFCGNCQASVPGLKSNKGEESGAGEPGKFDSAARKGDLGPRGPPGIPGREGPKGSKGERGYPGVPGEKGDEGLQGIPGLPGAPGPTGPPGLLGRTGHPGPMGTKGDKGSEGPPGRPGPPGPPGVPFNEGNGMSSLYKIQGGVNAPSYPGPPGPPGPKGDPGPVGEPGAMGLPGLEGFPGIKGDRGPAGPPGAAGISGKPGAPGPPGIPGEPGERGPVGDIGFPGPEGPSGKPGINGKDGLPGVQGIMGKPGERGPKGERGDQGIPGDRGPQGEQGKPGLQGIKGAIGPVGPPGNKGSPGSPGHQGPPGLPGLPGSPADVVSFEEIKKYINQEVLRIFEERMAVFLSQLKLPAAMLAAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGTSAPGLPGSPGAPGPQGPPGPSGRCNPEDCLYPVSHTRQRTGGK", "length": 1131, "header": "tr|A0AAA9SKZ7-1|A0AAA9SKZ7_BOVIN Isoform 1 of Collagen alpha-1(XIX) chain OS=Bos taurus OX=9913 GN=COL19A1 PE=3 SV=1 CANONICAL=A0AAA9SKZ7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7/entry#A0AAA9SKZ7-1", "sequence": { "sequence": "MRLAGSWRLWLWAAAFLLPASASVMSRDKPENQCPILRTEGRRFRQDNRDKLEVSGFDLAERFSLKHVFCEGDKTCFKLGSSLLIRDTIKIFPKGLPEEFAIAAMFRVRRSAKKERWFLWQVLNQRNMPQVSVIVDGGRKVVELMFQAAEGDVLNYIFKNQELRSLFDRQWHKLGFGIQSQAIALYVDCNLVASRHTDRNGTVDFRGRTVIAARASDGKPVDIELHQLQIYCNWNFIAQETCCEISDIKCPEQPGFGGTAASPAPAHASRMSAFLPAKQELTDQCQCMPHKGEAGSPGQKGEQGENGLRGTPGLPGQKGEQGFEGSKGETGEKGEPGEKGDPGLSGVNGQDGVKGDSGPRGPPGPKGDKGDMGPPGPPTLTGSLGIQGPQGPPGKEGQRGRRGKPGPPGKPGPPGPPGPPGVQGMQQTLDGYYHKGNVGEHGAGGLKGEKGETGSPGFPGSIGPKGEKGESGERFTKGEKGDRGEPGITGSQGIKGEPGDPGPPGVIGSPGLKGQQGPAGSVGPRGPPGDIGLPGEHGIPGKQGNKGEKGDPGGITGPPGLPGPKGEAGPPGKSLPGEPGLDGSPGAPGPRGPKGERGLPGVQGSPGDIGPPGIGIPGRTGSQGPAGEPGIQGPRGLPGLPGTPGTPGNDGAPGRDGKPGLPGPPGDPIALPLLGDIGALFKNFCGNCQASVPGLKSNKGEESGAGEPGKFDSAARKGDLGPRGPPGIPGREGPKGSKGERGYPGVPGEKGDEGLQGIPGLPGAPGPTGPPGLLGRTGHPGPMGTKGDKGSEGPPGRPGPPGPPGVPFNEGNGMSSLYKIQGGVNAPSYPGPPGPPGPKGDPGPVGEPGAMGLPGLEGFPGIKGDRGPAGPPGAAGISGKPGAPGPPGIPGEPGERGPVGDIGFPGPEGPSGKPGINGKDGLPGVQGIMGKPGERGPKGERGDQGIPGDRGPQGEQGKPGLQGIKGAIGPVGPPGNKGSPGSPGHQGPPGLPGLPGSPADVVSFEEIKKYINQEVLRIFEERMAVFLSQLKLPAAMLAAQAHGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGTSAPGLPGSPGAPGPQGPPGPSGRCNPEDCLYPVSHTRQRTGGK", "length": 1131, "header": "tr|A0AAA9SKZ7-1|A0AAA9SKZ7_BOVIN Isoform 1 of Collagen alpha-1(XIX) chain OS=Bos taurus OX=9913 GN=COL19A1 PE=3 SV=1 CANONICAL=A0AAA9SKZ7-1" }, "locus": { "chromosome": "9", "start_pos": 9291833, "end_pos": 8866217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102641.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102641.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085961.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 643, "start_aa": "Thr", "end_pos": 643, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr643", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 646, "start_aa": "Thr", "end_pos": 646, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr646", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 768, "start_aa": "Thr", "end_pos": 768, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr768", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100137749", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100137749", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKZ7" }, { "id": "SM00210", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00210" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thrombospondin-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 234, "start_aa": "Asp", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 643, 646, 768 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 200, "end_pos": 202 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SL15-1", "uniprot_ac": "A0AAA9SL15", "uniprot_id": "A0AAA9SL15_BOVIN", "mass": { "chemical_mass": 10849.0, "monoisotopic_mass": 10849.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SL15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL15/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL15" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL15", "locus": {} } ], "crossref": [ { "id": "A0AAA9SL15", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SL15", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SL15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPALLTTLPARMSLRSLKWSLLLLSLLSFLVMWYLSLPHYNVVERVNWMYFYEIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY", "length": 91, "header": "tr|A0AAA9SL15-1|A0AAA9SL15_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SL15-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL15/entry#A0AAA9SL15-1", "sequence": { "sequence": "MAPALLTTLPARMSLRSLKWSLLLLSLLSFLVMWYLSLPHYNVVERVNWMYFYEIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY", "length": 91, "header": "tr|A0AAA9SL15-1|A0AAA9SL15_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SL15-1" }, "locus": { "chromosome": "1", "start_pos": 106377767, "end_pos": 106376776, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127634.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127634.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084595.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084595.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SL22-1", "uniprot_ac": "A0AAA9SL22", "uniprot_id": "A0AAA9SL22_BOVIN", "mass": { "chemical_mass": 21848.0, "monoisotopic_mass": 21848.0 }, "refseq": { "ac": "XP_059745552", "name": "large ribosomal subunit protein uL6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745552" }, "gene_names": [ { "name": "LOC101905894", "type": "recommended", "evidence": [ { "id": "A0AAA9SL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ] }, { "name": "LOC101905894", "type": "synonym", "evidence": [ { "id": "XP_059745552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745552" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL6", "type": "recommended", "evidence": [ { "id": "A0AAA9SL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L9", "type": "synonym", "evidence": [ { "id": "A0AAA9SL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL6", "type": "synonym", "evidence": [ { "id": "XP_059745552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745552" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22#function" }, { "database": "UniProtKB", "id": "ARBA00034092", "url": "https://www.uniprot.org/uniprotkb/ARBA00034092#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101905894", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22", "locus": {} } ], "crossref": [ { "id": "A0AAA9SL22", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SL22", "database": "AlphaFoldDB", "categories": [] }, { "id": "101905894", "url": "https://www.ncbi.nlm.nih.gov/gene/101905894", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000702", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000702", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11655", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11655", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11655:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11655:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059745552", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745552", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTILSNQTVDIPENVDINLKGRTVIVKGPRGTLQRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE", "length": 192, "header": "tr|A0AAA9SL22-1|A0AAA9SL22_BOVIN Isoform 1 of Large ribosomal subunit protein uL6 OS=Bos taurus OX=9913 GN=LOC101905894 PE=3 SV=2 CANONICAL=A0AAA9SL22-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22/entry#A0AAA9SL22-1", "sequence": { "sequence": "MKTILSNQTVDIPENVDINLKGRTVIVKGPRGTLQRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE", "length": 192, "header": "tr|A0AAA9SL22-1|A0AAA9SL22_BOVIN Isoform 1 of Large ribosomal subunit protein uL6 OS=Bos taurus OX=9913 GN=LOC101905894 PE=3 SV=2 CANONICAL=A0AAA9SL22-1" }, "locus": { "chromosome": "8", "start_pos": 101977554, "end_pos": 101977433, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074464.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074464.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084606.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084606.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL22" }, { "id": "PF00347", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00347" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL6 alpha-beta", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 85, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SL74-1", "uniprot_ac": "A0AAA9SL74", "uniprot_id": "A0AAA9SL74_BOVIN", "mass": { "chemical_mass": 23893.0, "monoisotopic_mass": 23893.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Peroxisomal membrane protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SL74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL74/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL74", "locus": {} } ], "crossref": [ { "id": "A0AAA9SL74", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SL74", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15460", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15460", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15460:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15460:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SL74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "CNSNPGCQGVSPAPCLPPSATPALWSPHRSCGLCSLRSTHYCASAATTQHWPCLRASGTGLREKLRAILQATYTHSWNLARFVFLYKGLCALQSHVQGKTYQAHSFVSAFIGGLLVFGNNNNINSQISMYLLSRVLFALCRLGVEKGFIPEPRLDPFPWFSGLVWGLVLWLFEYHRPTLQPSLQSSMTYLYEDSNVWHDLSDFFIYNKSQPSK", "length": 213, "header": "tr|A0AAA9SL74-1|A0AAA9SL74_BOVIN Isoform 1 of Peroxisomal membrane protein 4 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SL74-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL74/entry#A0AAA9SL74-1", "sequence": { "sequence": "CNSNPGCQGVSPAPCLPPSATPALWSPHRSCGLCSLRSTHYCASAATTQHWPCLRASGTGLREKLRAILQATYTHSWNLARFVFLYKGLCALQSHVQGKTYQAHSFVSAFIGGLLVFGNNNNINSQISMYLLSRVLFALCRLGVEKGFIPEPRLDPFPWFSGLVWGLVLWLFEYHRPTLQPSLQSSMTYLYEDSNVWHDLSDFFIYNKSQPSK", "length": 213, "header": "tr|A0AAA9SL74-1|A0AAA9SL74_BOVIN Isoform 1 of Peroxisomal membrane protein 4 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SL74-1" }, "locus": { "chromosome": "1", "start_pos": 55458561, "end_pos": 55457855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084653.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 21, "start_aa": "Thr", "end_pos": 21, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr21", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 21 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SL84-1", "uniprot_ac": "A0AAA9SL84", "uniprot_id": "A0AAA9SL84_BOVIN", "mass": { "chemical_mass": 44539.0, "monoisotopic_mass": 44539.0 }, "refseq": { "ac": "NP_001193252", "name": "testis-specific Y-encoded-like protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193252" }, "gene_names": [ { "name": "TSPYL5", "type": "recommended", "evidence": [ { "id": "A0AAA9SL84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ] }, { "name": "TSPYL5", "type": "synonym", "evidence": [ { "id": "NP_001193252", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193252" } ] } ], "protein_names": [ { "name": "Testis-specific Y-encoded-like protein 5", "type": "recommended", "evidence": [ { "id": "A0AAA9SL84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84/entry#names_and_taxonomy" } ] }, { "name": "testis-specific Y-encoded-like protein 5", "type": "synonym", "evidence": [ { "id": "NP_001193252", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193252" } ] } ], "function": [ { "annotation": "Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.", "evidence": [ { "database": "UniProtKB", "id": "E1BAA3", "url": "https://www.uniprot.org/uniprotkb/E1BAA3#function" }, { "database": "UniProtKB", "id": "ARBA00059448", "url": "https://www.uniprot.org/uniprotkb/ARBA00059448#function" }, { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPYL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84", "locus": { "chromosome": "14", "start_pos": 66858294, "end_pos": 66852589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011572", "url": "https://www.ensembl.org/id/ENSBTAG00000011572" } ] } } ], "crossref": [ { "id": "A0AAA9SL84", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SL84", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011572", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011572", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615997", "url": "https://www.ncbi.nlm.nih.gov/gene/615997", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615997", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615997", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "APETCST", "url": "https://omabrowser.org/oma/group/APETCST/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAA3", "url": "https://www.orthodb.org/?gene=E1BAA3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11875", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11875", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193252", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA3", "url": "https://www.uniprot.org/uniprotkb/E1BAA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRSKGRRSSRAKGRGKSRAKGRVRAAPDDAPRDPDPPECQRLGEETKAAQVQAGAVWGGPEGAAPAPPRRPGEEAACRLPLDCGLALRARAAGTRGQAVTRPCLVKATSFPERLVSDTVFVGTVGTVARPRNGPRVGSRRGPAAKKAPDTCSAVGRGSAALAGGKPKKGPAAEAASVPVGEEKVENAGSGPPATEGSMDTLENVQLKLETMNAQADRAYLRLSRKFGQLRLHHLERRNLLIQNIPGFWGQAFQNHPQLSSFLNNQDKEVLSFLNSLEVEELGLARLGYKIKFYFGRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHDLQTLSQGNPDNSRSFFGWFSNHSSIESDKIVEIINEELWPNPLQYYLMSEGARAEKGKEGRPGPARPPGETPEPGVNKSN", "length": 413, "header": "tr|A0AAA9SL84-1|A0AAA9SL84_BOVIN Isoform 1 of Testis-specific Y-encoded-like protein 5 OS=Bos taurus OX=9913 GN=TSPYL5 PE=3 SV=1 CANONICAL=A0AAA9SL84-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84/entry#A0AAA9SL84-1", "sequence": { "sequence": "MSGRSKGRRSSRAKGRGKSRAKGRVRAAPDDAPRDPDPPECQRLGEETKAAQVQAGAVWGGPEGAAPAPPRRPGEEAACRLPLDCGLALRARAAGTRGQAVTRPCLVKATSFPERLVSDTVFVGTVGTVARPRNGPRVGSRRGPAAKKAPDTCSAVGRGSAALAGGKPKKGPAAEAASVPVGEEKVENAGSGPPATEGSMDTLENVQLKLETMNAQADRAYLRLSRKFGQLRLHHLERRNLLIQNIPGFWGQAFQNHPQLSSFLNNQDKEVLSFLNSLEVEELGLARLGYKIKFYFGRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHDLQTLSQGNPDNSRSFFGWFSNHSSIESDKIVEIINEELWPNPLQYYLMSEGARAEKGKEGRPGPARPPGETPEPGVNKSN", "length": 413, "header": "tr|A0AAA9SL84-1|A0AAA9SL84_BOVIN Isoform 1 of Testis-specific Y-encoded-like protein 5 OS=Bos taurus OX=9913 GN=TSPYL5 PE=3 SV=1 CANONICAL=A0AAA9SL84-1" }, "locus": { "chromosome": "14", "start_pos": 66858158, "end_pos": 66856920, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078464.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078464.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086026.1" } ] } }, { "isoform_ac": "E1BAA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84/entry#E1BAA3-1", "sequence": { "sequence": "MSGRSKGRRSSRAKGRGKSRAKGRVRAAPDDAPRDPDPPECQRLGEETKAAQVQAGAVWGGPEGAAPAPPRRPGEEAACRLPLDCGLALRARAAGTRGQAVTRPCLVKATSFPERLVSDTVFVGTVGTVARPRNGPRVGSRRGPAAKKAPDTCSAVGRGSAALAGGKPKKGPAAEAASVPVGEEKVENAGSGPPATEGSMDTLENVQLKLETMNAQADRAYLRLSRKFGQLRLHHLERRNLLIQNIPGFWGQAFQNHPQLSSFLNNQDKEVLSFLNSLEVEELGLARLGYKIKFYFGRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHDLQTLSQGNPDNSRSFFGWFSNHSSIESDKIVEIINEELWPNPLQYYLMSEGARAEKGKEGRPGPARPPGETPEPGPSRNPAGCWTDGQAGTCGHVLTVVKLWLQTCTEMERPRVPSPSYIIYQLWSTQFHLHLHLPACIVDRKSKTLCQFNWDHFGRLRHSAGGDRGGLHSHYRIRSAFCFSC", "length": 516, "header": "tr|E1BAA3-1|E1BAA3_BOVIN Computationally mapped isoform of Testis-specific Y-encoded-like protein 5 OS=Bos taurus OX=9913 GN=TSPYL5 PE=3 SV=4 CANONICAL=A0AAA9SL84-1" }, "locus": { "chromosome": "14", "start_pos": 66856881, "end_pos": 66853022, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056995.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056995.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052115.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052115.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615997", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615997", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q69ZB3-1", "protein_name": "Testis-specific Y-encoded-like protein 5", "gene_name": "Tspyl5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRSRGRKSSRAKGRGKGRARARVRAAAEDAWHDEKPPQSPRLGEDSAAAQVQAGAAQGGAEPAELREEAACRLPLDCGLALRARAADERGLAAPDPDLERARSLAERLTSDTSFVGTVGALAKLRRGSRIGNRRVPGRKAPDTRSATGRGPQATVSGKPKMASAGLCAAAPVGEEKKMTEKHAGAGSPATVGSMDTLETVQLKLETMNAQADRAYLRLSRKFGQLRLHHLERRNLLIQSIPGFWGQAFQNHPQLSAFLNTKDKEVLSYLNRLEVEELGLARLGYKIKFYFGRNPYFQNKVLIKEYGCGPSGQVVSRSAPIQWLPGHDLQSLSKENPENNGSFFGWFSNHSSIESDKIVEIINEDLWPNPLQYYLISEEARGEKGKEERPGPAKLSPAPAVRQPN", "length": 406 }, "evidence": [ { "id": "A0AAA9SL84", "url": "https://omabrowser.org/oma/group/A0AAA9SL84/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86VY4-1", "protein_name": "Testis-specific Y-encoded-like protein 5", "gene_name": "TSPYL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRSRGRKSSRAKNRGKGRAKARVRPAPDDAPRDPDPSQYQSLGEDTQAAQVQAGAGWGGLEAAASAQLLRLGEEAACRLPLDCGLALRARAAGDHGQAAARPGPGKAASLSERLAADTVFVGTAGTVGRPKNAPRVGNRRGPAGKKAPETCSTAGRGPQVIAGGRQKKGAAGENTSVSAGEEKKEERDAGSGPPATEGSMDTLENVQLKLENMNAQADRAYLRLSRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLASFLNSQEKEVLSYLNSLEVEELGLARLGYKIKFYFDRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHDLQSLSQGNPENNRSFFGWFSNHSSIESDKIVEIINEELWPNPLQFYLLSEGARVEKGKEKEGRQGPGKQPMETTQPGVSQSN", "length": 417 }, "evidence": [ { "id": "A0AAA9SL84", "url": "https://omabrowser.org/oma/group/A0AAA9SL84/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" }, { "name": "cellular response to gamma radiation", "id": "GO:0071480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071480", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 354, "end_pos": 356 }, { "start_pos": 410, "end_pos": 412 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLA7-1", "uniprot_ac": "A0AAA9SLA7", "uniprot_id": "A0AAA9SLA7_BOVIN", "mass": { "chemical_mass": 81807.0, "monoisotopic_mass": 81807.0 }, "refseq": { "ac": "XP_024848565", "name": "chondroadherin-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848565" }, "gene_names": [ { "name": "CHADL", "type": "recommended", "evidence": [ { "id": "A0AAA9SLA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ] }, { "name": "CHADL", "type": "synonym", "evidence": [ { "id": "XP_024848565", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848565" } ] } ], "protein_names": [ { "name": "Chondroadherin-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7/entry#names_and_taxonomy" } ] }, { "name": "chondroadherin-like protein", "type": "synonym", "evidence": [ { "id": "XP_024848565", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848565" } ] } ], "function": [ { "annotation": "Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.", "evidence": [ { "database": "UniProtKB", "id": "F1MCU5", "url": "https://www.uniprot.org/uniprotkb/F1MCU5#function" }, { "database": "UniProtKB", "id": "ARBA00053126", "url": "https://www.uniprot.org/uniprotkb/ARBA00053126#function" }, { "database": "UniProtKB", "id": "A0A3Q1LWM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWM4#function" }, { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHADL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7", "locus": { "chromosome": "5", "start_pos": 112381648, "end_pos": 112392835, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040106", "url": "https://www.ensembl.org/id/ENSBTAG00000040106" } ] } } ], "crossref": [ { "id": "A0AAA9SLA7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040106", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040106", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100847739", "url": "https://www.ncbi.nlm.nih.gov/gene/100847739", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847739", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847739", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF210", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF210", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF213", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF213", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848565", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848565", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCU5", "url": "https://www.uniprot.org/uniprotkb/F1MCU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCU5-1", "url": "https://www.uniprot.org/uniprotkb/F1MCU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPQSLSLVLLLPLLLPLGPNRCAVAQRCPQACVCDNPRRHVACRHQNLTEVPTAIPELTQRLDLQGNMLKEIPPAAFRDLPHLTHLDLRRCQVELVAEGAFRGLGRLLLLNLASNRLRALPQEALDGLGSLQRLELAGNLLEELRPGTFGALGAVTTLNLAHNALVYLPAMAFQGLVRARWLQLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGAALSQARGLARLELGHNPFTYTGEEDGLALPGLRELRLDHGALQALDARAFARCPRLHTLDLRGNQLDALPPLQGPGQLRRLRLQGNPLWCGCRARPLLEWLARARVRSDGACWGPRRLRGEALDALRPSDLRCPRPGAEEEEEAEELKAARPRAPGDAPGEEAGAAGPCPRTCVCVPESRHSSCEGRGLQAVPRGFPNDTQLLDLRRNRFPVVPQAAFPGLGRLVSLHLQHCGLTELEAGALAGLDSLIYLYLSDNRLSGLSAAALEGAPRLGYLYLERNRFVRMPGAALLALPSLFSLHLQDNALDHLAPGDLAGGRALRWLYLSGNRLARVSPGALGPARELEKLHLDRNQLGEVPTEALEGLPALLELQLSGNPLGALRDGAFRPVGRSLQHLFLNSSGLEQISPGAFSGLGPRLRSLHLQKNQLQTLPALPGLGELELVDLSGNPFHCDCQLLPLHRWLAGLNLRVGATCATPPSARGQRVKAAAAVFEACPGQAARKAKRTPAPRPGAWGTPTKGRRQRANKEYKGLEGHGL", "length": 758, "header": "tr|A0AAA9SLA7-1|A0AAA9SLA7_BOVIN Isoform 1 of Chondroadherin-like protein OS=Bos taurus OX=9913 GN=CHADL PE=3 SV=1 CANONICAL=A0AAA9SLA7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7/entry#A0A3Q1LWM4-1", "sequence": { "sequence": "MAGPQSLSLVLLLPLLLPLGPNRCAVAQRCPQACVCDNPRRHVACRHQNLTEVPTAIPELTQRLDLQGNMLKEIPPAAFRDLPHLTHLDLRRCQVELVAEGAFRGLGRLLLLNLASNRLRALPQEALDGLGSLQRLELAGNLLEELRPGTFGALGAVTTLNLAHNALVYLPAMAFQGLVRARWLQLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGAALSQARGLARLELGHNPFTYTGEEDGLALPGLRELRLDHGALQALDARAFARCPRLHTLDLRGNQLDALPPLQGPGQLRRLRLQGNPLWCGCRARPLLEWLARARVRSDGACWGPRRLRGEALDALRPSDLRCPRPGAEEEEEAEELKAARPRAPGDAPGEEAGAAGPCPRTCVCVPESRHSSCEGRGLQAVPRGFPNDTQLLDLRRNRFPVVPQAAFPGLGRLVSLHLQHCGLTELEAGALAGLDSLIYLYLSDNRLSGLSAAALEGAPRLGYLYLERNRFVRMPGAALLALPSLFSLHLQDNALDHLAPGDLAGGRALRWLYLSGNRLARVSPGALGPARELEKLHLDRNQLGEVPTEALEGLPALLELQLSGNPLGALRDGAFRPVGRSLQHLFLNSSGLEQISPGAFSGLGPRLRSLHLQKNQLQTLPALPGLGELELVDLSGNPFHCDCQLLPLHRWLAGLNLRVGATCATPPSARGQRVKAAAAVFEACPGQAARKAKRTPAPRPGAWGTPTKGRRQRANKVGKEATGL", "length": 756, "header": "tr|A0A3Q1LWM4-1|A0A3Q1LWM4_BOVIN Computationally mapped isoform of Chondroadherin-like protein OS=Bos taurus OX=9913 GN=CHADL PE=3 SV=2 CANONICAL=A0AAA9SLA7-1" }, "locus": { "chromosome": "5", "start_pos": 112392542, "end_pos": 112381651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085555.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085555.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061836.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061836.2" } ] } }, { "isoform_ac": "A0AAA9SLA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7/entry#A0AAA9SLA7-1", "sequence": { "sequence": "MAGPQSLSLVLLLPLLLPLGPNRCAVAQRCPQACVCDNPRRHVACRHQNLTEVPTAIPELTQRLDLQGNMLKEIPPAAFRDLPHLTHLDLRRCQVELVAEGAFRGLGRLLLLNLASNRLRALPQEALDGLGSLQRLELAGNLLEELRPGTFGALGAVTTLNLAHNALVYLPAMAFQGLVRARWLQLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGAALSQARGLARLELGHNPFTYTGEEDGLALPGLRELRLDHGALQALDARAFARCPRLHTLDLRGNQLDALPPLQGPGQLRRLRLQGNPLWCGCRARPLLEWLARARVRSDGACWGPRRLRGEALDALRPSDLRCPRPGAEEEEEAEELKAARPRAPGDAPGEEAGAAGPCPRTCVCVPESRHSSCEGRGLQAVPRGFPNDTQLLDLRRNRFPVVPQAAFPGLGRLVSLHLQHCGLTELEAGALAGLDSLIYLYLSDNRLSGLSAAALEGAPRLGYLYLERNRFVRMPGAALLALPSLFSLHLQDNALDHLAPGDLAGGRALRWLYLSGNRLARVSPGALGPARELEKLHLDRNQLGEVPTEALEGLPALLELQLSGNPLGALRDGAFRPVGRSLQHLFLNSSGLEQISPGAFSGLGPRLRSLHLQKNQLQTLPALPGLGELELVDLSGNPFHCDCQLLPLHRWLAGLNLRVGATCATPPSARGQRVKAAAAVFEACPGQAARKAKRTPAPRPGAWGTPTKGRRQRANKEYKGLEGHGL", "length": 758, "header": "tr|A0AAA9SLA7-1|A0AAA9SLA7_BOVIN Isoform 1 of Chondroadherin-like protein OS=Bos taurus OX=9913 GN=CHADL PE=3 SV=1 CANONICAL=A0AAA9SLA7-1" }, "locus": { "chromosome": "5", "start_pos": 112392542, "end_pos": 112384736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103998.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103998.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084694.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084694.1" } ] } }, { "isoform_ac": "F1MCU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7/entry#F1MCU5-1", "sequence": { "sequence": "MAGPQSLSLVLLLPLLLPLGPNRCAVAQRCPQACVCDNPRRHVACRHQNLTEVPTAIPELTQRLDLQGNMLKEIPPAAFRDLPHLTHLDLRRCQVELVAEGAFRGLGRLLLLNLASNRLRALPQEALDGLGSLQRLELAGNLLEELRPGTFGALGAVTTLNLAHNALVYLPAMAFQGLVRARWLQLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGAALSQARGLARLELGHNPFTYTGEEDGLALPGLRELRLDHGALQALDARAFARCPRLHTLDLRGNQLDALPPLQGPGQLRRLRLQGNPLWCGCRARPLLEWLARARVRSDGACWGPRRLRGEALDALRPSDLRCPRPGAEEEEEAEELKAARPRAPGDAPGEEAGAAGPCPRTCVCVPESRHSSCEGRGLQAVPRGFPNDTQLLDLRRNRFPVVPQAAFPGLGRLVSLHLQHCGLTELEAGALAGLDSLIYLYLSDNRLSGLSAAALEGAPRLGYLYLERNRFVRMPGAALLALPSLFSLHLQDNALDHLAPGDLAGGRALRWLYLSGNRLARVSPGALGPARELEKLHLDRNQLGEVPTEALEGLPALLELQLSGNPLGALRDGAFRPVGRSLQHLFLNSSGLEQISPGAFSGLGPRLRSLHLQKNQLQTLPALPGLGELELVDLSGNPFHCDCQLLPLHRWLAGLNLRVGATCATPPSARGQRVKAAAAVFEACPGQAARKAKRTPAPRPGAWGTPTKGRRQRANKDLK", "length": 751, "header": "tr|F1MCU5-1|F1MCU5_BOVIN Computationally mapped isoform of Chondroadherin-like protein OS=Bos taurus OX=9913 GN=CHADL PE=3 SV=4 CANONICAL=A0AAA9SLA7-1" }, "locus": { "chromosome": "5", "start_pos": 112392542, "end_pos": 112385205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055322.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055322.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050251.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050251.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 580, "start_aa": "Thr", "end_pos": 580, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr580", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100847739", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847739", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "collagen fibril binding", "id": "GO:0098633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098633", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "Roundabout binding", "id": "GO:0048495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048495", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "toll-like receptor signaling pathway", "id": "GO:0002224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "negative regulation of chondrocyte differentiation", "id": "GO:0032331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032331", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "negative regulation of collagen fibril organization", "id": "GO:1904027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" }, { "name": "gel phase of interstitial matrix", "id": "GO:0140150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140150", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 307, "end_pos": 355, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SLA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA7" }, { "id": "SM00013", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRNT", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 63, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 580 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 419, "end_pos": 421 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 620, "end_pos": 622 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLC3-1", "uniprot_ac": "A0AAA9SLC3", "uniprot_id": "A0AAA9SLC3_BOVIN", "mass": { "chemical_mass": 89331.0, "monoisotopic_mass": 89331.0 }, "refseq": {}, "gene_names": [ { "name": "PCDHB7", "type": "recommended", "evidence": [ { "id": "A0AAA9SLC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3" } ] } ], "protein_names": [ { "name": "Protocadherin beta 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SLC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDHB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3", "locus": { "chromosome": "7", "start_pos": 52293005, "end_pos": 52290615, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060447", "url": "https://www.ensembl.org/id/ENSBTAG00000060447" } ] } } ], "crossref": [ { "id": "A0AAA9SLC3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLC3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787102", "url": "https://www.ncbi.nlm.nih.gov/gene/787102", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787102", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787102", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF69", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF69", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFLSCLRTRESVFERLVKRRMDARVECAVQQRQVLFLCVFLGMSWAAEEPLVYFVEEEAERGTLLANLAHDLGLGMEELSAREPRVISDQKIGFLLLDPLTGDVSLNEKLDREELCGPKEPCVLPFQLLMEKPFEIFRAKLWVRDINDHSPVFLDREILLKILESTTPGAAFLLQSAQDSDIGTNNVRNYTISPNAYFHISVHNGADGIIYPELVLDRPLDREEVPELSLILTALDGGSPPRSGTTLVRILVLDINDNAPEFVQPLYKVQLCEDSPVGSLVVTVSARDLDTGSNGEIVYAFFYATERILNTFQINPTSGSVYLKAELNYEVIQTYTLTIQAKDGGGLSGKCTVVIQVTDINDNPPELLMSSLTSPIQENSLETVVAVFRIRDRDSGNNAKMVCSIQDDLPFVLKPSVENYYTLVTDSPLDREERAEYNITITVIDMGTPRLKTEHSVTVLVSDVNDNAPTFTQTSYTLWVRENNSPALHIGSVSATDTDAGANAQVTYSLLPPPDPLVPLASLVSINPDNGHLFALTSLDYEALRAFEFRVGATDRGSPALSSQALVRVLVADANDNAPFVLYPLQNASAPCTELVPRAAEPGYLVTKVVAVDGDAGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAPKQRLVVLVKDNGEPPLSASVTLHVLLVDGFSQPYLPAPEAEAAAAALADPLTVYLVVALASVSSLFLFSVLVFVAVRLCRRGGAASAGRCPVAEGHFPGHLVDVSGTGTLSQSYQCEVGLMGGSGTGEFKFLKPILPNLAFQSIGREVEEYPSYRNDLGLW", "length": 818, "header": "tr|A0AAA9SLC3-1|A0AAA9SLC3_BOVIN Isoform 1 of Protocadherin beta 7 OS=Bos taurus OX=9913 GN=PCDHB7 PE=4 SV=2 CANONICAL=A0AAA9SLC3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3/entry#A0AAA9SLC3-1", "sequence": { "sequence": "MPFLSCLRTRESVFERLVKRRMDARVECAVQQRQVLFLCVFLGMSWAAEEPLVYFVEEEAERGTLLANLAHDLGLGMEELSAREPRVISDQKIGFLLLDPLTGDVSLNEKLDREELCGPKEPCVLPFQLLMEKPFEIFRAKLWVRDINDHSPVFLDREILLKILESTTPGAAFLLQSAQDSDIGTNNVRNYTISPNAYFHISVHNGADGIIYPELVLDRPLDREEVPELSLILTALDGGSPPRSGTTLVRILVLDINDNAPEFVQPLYKVQLCEDSPVGSLVVTVSARDLDTGSNGEIVYAFFYATERILNTFQINPTSGSVYLKAELNYEVIQTYTLTIQAKDGGGLSGKCTVVIQVTDINDNPPELLMSSLTSPIQENSLETVVAVFRIRDRDSGNNAKMVCSIQDDLPFVLKPSVENYYTLVTDSPLDREERAEYNITITVIDMGTPRLKTEHSVTVLVSDVNDNAPTFTQTSYTLWVRENNSPALHIGSVSATDTDAGANAQVTYSLLPPPDPLVPLASLVSINPDNGHLFALTSLDYEALRAFEFRVGATDRGSPALSSQALVRVLVADANDNAPFVLYPLQNASAPCTELVPRAAEPGYLVTKVVAVDGDAGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAPKQRLVVLVKDNGEPPLSASVTLHVLLVDGFSQPYLPAPEAEAAAAALADPLTVYLVVALASVSSLFLFSVLVFVAVRLCRRGGAASAGRCPVAEGHFPGHLVDVSGTGTLSQSYQCEVGLMGGSGTGEFKFLKPILPNLAFQSIGREVEEYPSYRNDLGLW", "length": 818, "header": "tr|A0AAA9SLC3-1|A0AAA9SLC3_BOVIN Isoform 1 of Protocadherin beta 7 OS=Bos taurus OX=9913 GN=PCDHB7 PE=4 SV=2 CANONICAL=A0AAA9SLC3-1" }, "locus": { "chromosome": "7", "start_pos": 52293005, "end_pos": 52290552, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110087.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110087.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084721.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084721.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787102", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787102", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLC3" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 263, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 588, "end_pos": 590 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLF0-1", "uniprot_ac": "A0AAA9SLF0", "uniprot_id": "A0AAA9SLF0_BOVIN", "mass": { "chemical_mass": 42990.0, "monoisotopic_mass": 42990.0 }, "refseq": { "ac": "XP_024839108", "name": "atypical chemokine receptor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839108" }, "gene_names": [ { "name": "LOC112443512", "type": "recommended", "evidence": [ { "id": "A0AAA9SLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ] }, { "name": "LOC112443512", "type": "synonym", "evidence": [ { "id": "XP_024839108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839108" } ] } ], "protein_names": [ { "name": "Atypical chemokine receptor 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0/entry#names_and_taxonomy" } ] }, { "name": "C-C chemokine receptor D6", "type": "synonym", "evidence": [ { "id": "A0AAA9SLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0/entry#names_and_taxonomy" } ] }, { "name": "Chemokine-binding protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0/entry#names_and_taxonomy" } ] }, { "name": "Chemokine-binding protein D6", "type": "synonym", "evidence": [ { "id": "A0AAA9SLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0/entry#names_and_taxonomy" } ] }, { "name": "atypical chemokine receptor 2", "type": "synonym", "evidence": [ { "id": "XP_024839108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839108" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112443512", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0", "locus": {} } ], "crossref": [ { "id": "112443512", "url": "https://www.ncbi.nlm.nih.gov/gene/112443512", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112443512", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112443512", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10489:SF942", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10489:SF942", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839108", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839108", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATTASPLPPTTKVASSENSSSFYDYEYYLEDMIFMLCRKDEVLSFGRVFLPVFYSLIFVLGLVGNLLLLAVLLRFVPRRRMTETYLLNLAISNLLFVVTLPFWGISVAWHWVFGSVLCKVVSTLYTVNFYSGIFFISCMSLDKYLEIVCARPYHRLRTRAKSLLLAASVWAMALAVSIPDMVFVRTHENSPGVWECYADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGSVLVSLRPPGQRRALRMAVALVVAFFVLWFPYNLTLFLHSLLDLQVFGDCRVSQHLDYALQVTESIAFLHCCFTPVLYAFSSHRFRQYLKAFLATVLRRQQALPSSYSESSGLTAQEDVMGMSDLGERLAESSPARGTEGKTA", "length": 379, "header": "tr|A0AAA9SLF0-1|A0AAA9SLF0_BOVIN Isoform 1 of Atypical chemokine receptor 2 OS=Bos taurus OX=9913 GN=LOC112443512 PE=4 SV=1 CANONICAL=A0AAA9SLF0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0/entry#A0AAA9SLF0-1", "sequence": { "sequence": "MATTASPLPPTTKVASSENSSSFYDYEYYLEDMIFMLCRKDEVLSFGRVFLPVFYSLIFVLGLVGNLLLLAVLLRFVPRRRMTETYLLNLAISNLLFVVTLPFWGISVAWHWVFGSVLCKVVSTLYTVNFYSGIFFISCMSLDKYLEIVCARPYHRLRTRAKSLLLAASVWAMALAVSIPDMVFVRTHENSPGVWECYADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGSVLVSLRPPGQRRALRMAVALVVAFFVLWFPYNLTLFLHSLLDLQVFGDCRVSQHLDYALQVTESIAFLHCCFTPVLYAFSSHRFRQYLKAFLATVLRRQQALPSSYSESSGLTAQEDVMGMSDLGERLAESSPARGTEGKTA", "length": 379, "header": "tr|A0AAA9SLF0-1|A0AAA9SLF0_BOVIN Isoform 1 of Atypical chemokine receptor 2 OS=Bos taurus OX=9913 GN=LOC112443512 PE=4 SV=1 CANONICAL=A0AAA9SLF0-1" }, "locus": { "chromosome": "22", "start_pos": 14948618, "end_pos": 14947482, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122680.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122680.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084094.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112443512", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112443512", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chemokine receptor activity", "id": "GO:0004950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004950", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLF0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 314, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 269, "end_pos": 271 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLG8-1", "uniprot_ac": "A0AAA9SLG8", "uniprot_id": "A0AAA9SLG8_BOVIN", "mass": { "chemical_mass": 35065.0, "monoisotopic_mass": 35065.0 }, "refseq": { "ac": "NP_001377304", "name": "olfactory receptor family 5 subfamily H member 30", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304" }, "gene_names": [ { "name": "OR5H30", "type": "recommended", "evidence": [ { "id": "A0AAA9SLG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8" } ] }, { "name": "OR5H30", "type": "synonym", "evidence": [ { "id": "NP_001377304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SLG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 5H2", "type": "synonym", "evidence": [ { "id": "NP_001377304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304" } ] }, { "name": "olfactory receptor 5H8", "type": "synonym", "evidence": [ { "id": "NP_001377304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304" } ] }, { "name": "olfactory receptor family 5 subfamily H member 30", "type": "synonym", "evidence": [ { "id": "NP_001377304", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5H30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8", "locus": { "chromosome": "1", "start_pos": 42467104, "end_pos": 42466175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057799", "url": "https://www.ensembl.org/id/ENSBTAG00000057799" } ] } } ], "crossref": [ { "id": "A0AAA9SLG8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "783843", "url": "https://www.ncbi.nlm.nih.gov/gene/783843", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783843", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783843", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377304", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SLG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METKNATELTEFILTGLIHQPEWQIPLFLLFLMIYLITIMGNLGLIALIYNDPHLHIPMYLFLGSLAFVDAWVSSTVTPKMLVNFLGKSKMTSLSECRAQFFSFVISVTTECFLLSTMAYDRYVAICKPLLYPVIMTDRLCMQLVVLSFLGGLIHSTIHTGLLFRVTFCNSNIIHHFYCDIMPLIKISCTDPSINVLMVSIFSGSIQVFTILIVLISYSLILFTILKKKSIQGIRKAFSTCGAHLLSVSLYYGPLLFMYVHPGSEQADDQDMIDSLFYTVIIPFLNPIIYSLRNKKVIDSLTKVLKRYS", "length": 309, "header": "tr|A0AAA9SLG8-1|A0AAA9SLG8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5H30 PE=3 SV=1 CANONICAL=A0AAA9SLG8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8/entry#A0AAA9SLG8-1", "sequence": { "sequence": "METKNATELTEFILTGLIHQPEWQIPLFLLFLMIYLITIMGNLGLIALIYNDPHLHIPMYLFLGSLAFVDAWVSSTVTPKMLVNFLGKSKMTSLSECRAQFFSFVISVTTECFLLSTMAYDRYVAICKPLLYPVIMTDRLCMQLVVLSFLGGLIHSTIHTGLLFRVTFCNSNIIHHFYCDIMPLIKISCTDPSINVLMVSIFSGSIQVFTILIVLISYSLILFTILKKKSIQGIRKAFSTCGAHLLSVSLYYGPLLFMYVHPGSEQADDQDMIDSLFYTVIIPFLNPIIYSLRNKKVIDSLTKVLKRYS", "length": 309, "header": "tr|A0AAA9SLG8-1|A0AAA9SLG8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5H30 PE=3 SV=1 CANONICAL=A0AAA9SLG8-1" }, "locus": { "chromosome": "1", "start_pos": 42467101, "end_pos": 42466175, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128508.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128508.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083497.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083497.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783843", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783843", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLH8-1", "uniprot_ac": "A0AAA9SLH8", "uniprot_id": "A0AAA9SLH8_BOVIN", "mass": { "chemical_mass": 11741.0, "monoisotopic_mass": 11741.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLH8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GDSVNQTEGPVTVSEGALLTLNCTYQTANSAPYLFWYVQHLNKAPQLLLKGLTADKKVEHEGFQATPIKRDSSFHLQKQAVQASDSAVYYCALSDTVREGCGGAEHKP", "length": 108, "header": "tr|A0AAA9SLH8-1|A0AAA9SLH8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SLH8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8/entry#A0AAA9SLH8-1", "sequence": { "sequence": "GDSVNQTEGPVTVSEGALLTLNCTYQTANSAPYLFWYVQHLNKAPQLLLKGLTADKKVEHEGFQATPIKRDSSFHLQKQAVQASDSAVYYCALSDTVREGCGGAEHKP", "length": 108, "header": "tr|A0AAA9SLH8-1|A0AAA9SLH8_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SLH8-1" }, "locus": { "chromosome": "10", "start_pos": 25031595, "end_pos": 25031272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096210.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096210.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086101.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086101.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLH8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 108, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLK1-1", "uniprot_ac": "A0AAA9SLK1", "uniprot_id": "A0AAA9SLK1_BOVIN", "mass": { "chemical_mass": 16094.0, "monoisotopic_mass": 16094.0 }, "refseq": {}, "gene_names": [ { "name": "SYNJ2BP", "type": "recommended", "evidence": [ { "id": "A0AAA9SLK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ] } ], "protein_names": [ { "name": "Synaptojanin-2-binding protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial outer membrane protein 25", "type": "synonym", "evidence": [ { "id": "A0AAA9SLK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNJ2BP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1", "locus": { "chromosome": "10", "start_pos": 81979141, "end_pos": 82020581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007586", "url": "https://www.ensembl.org/id/ENSBTAG00000007586" } ] } } ], "crossref": [ { "id": "A0AAA9SLK1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007586", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007586", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06709", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06709", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FRNAGCD", "url": "https://omabrowser.org/oma/group/FRNAGCD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQE8", "url": "https://www.orthodb.org/?gene=F1MQE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQE8", "url": "https://www.uniprot.org/uniprotkb/F1MQE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQE8-1", "url": "https://www.uniprot.org/uniprotkb/F1MQE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIFVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGPQGIQKKKAVDGIRPEWKEKAFKTKSQLRLCLWVTYL", "length": 145, "header": "tr|A0AAA9SLK1-1|A0AAA9SLK1_BOVIN Isoform 1 of Synaptojanin-2-binding protein OS=Bos taurus OX=9913 GN=SYNJ2BP PE=4 SV=1 CANONICAL=A0AAA9SLK1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1/entry#A0AAA9SLK1-1", "sequence": { "sequence": "MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIFVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGPQGIQKKKAVDGIRPEWKEKAFKTKSQLRLCLWVTYL", "length": 145, "header": "tr|A0AAA9SLK1-1|A0AAA9SLK1_BOVIN Isoform 1 of Synaptojanin-2-binding protein OS=Bos taurus OX=9913 GN=SYNJ2BP PE=4 SV=1 CANONICAL=A0AAA9SLK1-1" }, "locus": { "chromosome": "10", "start_pos": 82020489, "end_pos": 81979711, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113652.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113652.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083522.1" } ] } }, { "isoform_ac": "F1MQE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1/entry#F1MQE8-1", "sequence": { "sequence": "MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIFVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGPQGEGEPSGIPIAMVLVPVFALTMVASWAFMRYRQRL", "length": 145, "header": "tr|F1MQE8-1|A0AAA9SLK1_BOVIN Computationally mapped isoform of Synaptojanin-2-binding protein OS=Bos taurus OX=9913 GN=SYNJ2BP PE=4 SV=1 CANONICAL=A0AAA9SLK1-1" }, "locus": { "chromosome": "10", "start_pos": 82020489, "end_pos": 81981768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020908.3", "url": "https://www.ensembl.org/id/ENSBTAT00000020908.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020908.2", "url": "https://www.ensembl.org/id/ENSBTAP00000020908.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QJF8-1", "protein_name": "Synaptojanin-2-binding protein", "gene_name": "Synj2bp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNGRVDYIVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKEDGAAARDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLPVQNGPIVHRGEGEPSGIPVAMVLLPVFALTMVAVWAFVRYRKQL", "length": 145 }, "evidence": [ { "id": "A0AAA9SLK1", "url": "https://omabrowser.org/oma/group/A0AAA9SLK1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P57105-1", "protein_name": "Synaptojanin-2-binding protein", "gene_name": "SYNJ2BP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVPVFALTMVAAWAFMRYRQQL", "length": 145 }, "evidence": [ { "id": "A0AAA9SLK1", "url": "https://omabrowser.org/oma/group/A0AAA9SLK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D6K5-1", "protein_name": "Synaptojanin-2-binding protein", "gene_name": "Synj2bp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKEDGAAAQDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGCAVSLRVQHRLPVQNGPIVHRGEGEPSGVPVAMVLLPVFALTMVAVWAFVRYRKQL", "length": 145 }, "evidence": [ { "id": "A0AAA9SLK1", "url": "https://omabrowser.org/oma/group/A0AAA9SLK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9WVJ4-1", "protein_name": "Synaptojanin-2-binding protein", "gene_name": "Synj2bp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNGRVDYLVSEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKEDGAAARDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLPVQNGPIVHRGDGEPSGVPVAVVLLPVFALTLVAVWAFVRYRKQL", "length": 145 }, "evidence": [ { "id": "A0AAA9SLK1", "url": "https://omabrowser.org/oma/group/A0AAA9SLK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of endothelial cell proliferation", "id": "GO:0001937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001937", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "pmid": "" }, { "name": "negative regulation of ERK1 and ERK2 cascade", "id": "GO:0070373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell migration", "id": "GO:0010596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010596", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "pmid": "" }, { "name": "regulation of Notch signaling pathway", "id": "GO:0008593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "pmid": "" }, { "name": "negative regulation of sprouting angiogenesis", "id": "GO:1903671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903671", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK1" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 100, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLK5-1", "uniprot_ac": "A0AAA9SLK5", "uniprot_id": "A0AAA9SLK5_BOVIN", "mass": { "chemical_mass": 2199.0, "monoisotopic_mass": 2199.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SLK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SAGWKKIFGKATELIVAPPGK", "length": 21, "header": "tr|A0AAA9SLK5-1|A0AAA9SLK5_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SLK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK5/entry#A0AAA9SLK5-1", "sequence": { "sequence": "SAGWKKIFGKATELIVAPPGK", "length": 21, "header": "tr|A0AAA9SLK5-1|A0AAA9SLK5_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SLK5-1" }, "locus": { "chromosome": "4", "start_pos": 82699863, "end_pos": 82699801, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111204.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111204.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084804.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084804.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLL2-1", "uniprot_ac": "A0AAA9SLL2", "uniprot_id": "A0AAA9SLL2_BOVIN", "mass": { "chemical_mass": 27869.0, "monoisotopic_mass": 27869.0 }, "refseq": {}, "gene_names": [ { "name": "BTG2", "type": "recommended", "evidence": [ { "id": "A0AAA9SLL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2" } ] } ], "protein_names": [ { "name": "BTG anti-proliferation factor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SLL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLL2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "539364", "url": "https://www.ncbi.nlm.nih.gov/gene/539364", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539364", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539364", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKNQIML", "url": "https://omabrowser.org/oma/group/CKNQIML/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22978", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22978", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22978:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22978:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SGPGPFAPSGRGPRPSAWGWVRRGSSWLLPSALSRAQSPDCDPGSPLGAAEAGCLWVCVRAVLPHWTQDPAGDSPTSRGSLWNEKAQWNLPNNSGSQPRLFRPRGPRRAWGSGWHLKLESGSPFYPPASLSHLPPFLVPREAEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYQEAPVATSYGLLTCKNQMILGRSSPSKNYIMAVSS", "length": 253, "header": "tr|A0AAA9SLL2-1|A0AAA9SLL2_BOVIN Isoform 1 of BTG anti-proliferation factor 2 OS=Bos taurus OX=9913 GN=BTG2 PE=3 SV=1 CANONICAL=A0AAA9SLL2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2/entry#A0AAA9SLL2-1", "sequence": { "sequence": "SGPGPFAPSGRGPRPSAWGWVRRGSSWLLPSALSRAQSPDCDPGSPLGAAEAGCLWVCVRAVLPHWTQDPAGDSPTSRGSLWNEKAQWNLPNNSGSQPRLFRPRGPRRAWGSGWHLKLESGSPFYPPASLSHLPPFLVPREAEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYQEAPVATSYGLLTCKNQMILGRSSPSKNYIMAVSS", "length": 253, "header": "tr|A0AAA9SLL2-1|A0AAA9SLL2_BOVIN Isoform 1 of BTG anti-proliferation factor 2 OS=Bos taurus OX=9913 GN=BTG2 PE=3 SV=1 CANONICAL=A0AAA9SLL2-1" }, "locus": { "chromosome": "16", "start_pos": 1089344, "end_pos": 1087667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092269.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092269.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087254.1" } ] } }, { "isoform_ac": "A0AAA9STP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2/entry#A0AAA9STP0-1", "sequence": { "sequence": "MLPEIAAAVGFLSSLLRTRGCVNEQRLQVFRGALQAALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYQEAPVATSYGLLTCKNQMILGRSSPSKNYIMAVSS", "length": 150, "header": "tr|A0AAA9STP0-1|A0AAA9STP0_BOVIN Computationally mapped isoform of BTG anti-proliferation factor 2 OS=Bos taurus OX=9913 GN=BTG2 PE=3 SV=1 CANONICAL=A0AAA9SLL2-1" }, "locus": { "chromosome": "16", "start_pos": 1089344, "end_pos": 1087483, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086459.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539364", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539364", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3AWP4-1", "protein_name": "BTG anti-proliferation factor 2", "gene_name": "BTG2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQRRGPPPRADMLPEIAAAVGFVSGLLRTRGCVSEQQLQVFSGALREALAEHYKHHWFPEKPFKGSGYRCIRINHKMDPIISKAASQIGLSLPQLYQLLPSELTLWVDPYEVSYRIGEDGSICVLYEATAAKPVSSYGMLTCKNQMMIGRTSPSKNYIMTVSS", "length": 164 }, "evidence": [ { "id": "A0AAA9SLL2", "url": "https://omabrowser.org/oma/group/A0AAA9SLL2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B0F7G7-1", "protein_name": "BTG anti-proliferation factor 2", "gene_name": "BTG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSQARWTGKRTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQEALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVATSYGLLTCKNQMMLGRSSPSKNYVMAVSS", "length": 162 }, "evidence": [ { "id": "A0AAA9SLL2", "url": "https://omabrowser.org/oma/group/A0AAA9SLL2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HQC8-1", "protein_name": "Protein BTG2", "gene_name": "Btg2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSHGKRTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVAASYGLLTCKNQMMLGRSSPSKNYVMAVSS", "length": 158 }, "evidence": [ { "id": "A0AAA9SLL2", "url": "https://omabrowser.org/oma/group/A0AAA9SLL2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P27049-1", "protein_name": "Protein BTG2", "gene_name": "Btg2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHGKRTDMLPEIAAAVGFLTSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVATSYGLLTCKNQMMLGRSSPSKNYVMTVSS", "length": 158 }, "evidence": [ { "id": "A0AAA9SLL2", "url": "https://omabrowser.org/oma/group/A0AAA9SLL2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P78543-1", "protein_name": "Protein BTG2", "gene_name": "BTG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSHGKGTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQEALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISRVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPLAASCGLLTCKNQVLLGRSSPSKNYVMAVSS", "length": 158 }, "evidence": [ { "id": "A0AAA9SLL2", "url": "https://omabrowser.org/oma/group/A0AAA9SLL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q04211-1", "protein_name": "Protein BTG2", "gene_name": "Btg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSHGKRTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVAASYGLLTCKNQMMLGRSSPSKNYVMAVSS", "length": 158 }, "evidence": [ { "id": "A0AAA9SLL2", "url": "https://omabrowser.org/oma/group/A0AAA9SLL2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL2" }, { "id": "PS00960", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00960" }, { "id": "PS01203", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01203" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Anti-proliferative protein", "eco_id": "ECO_0000259", "start_pos": 145, "end_pos": 165, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLN8-1", "uniprot_ac": "A0AAA9SLN8", "uniprot_id": "A0AAA9SLN8_BOVIN", "mass": { "chemical_mass": 180891.0, "monoisotopic_mass": 180891.0 }, "refseq": {}, "gene_names": [ { "name": "KIF14", "type": "recommended", "evidence": [ { "id": "A0AAA9SLN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ] } ], "protein_names": [ { "name": "Kinesin-like protein KIF14", "type": "recommended", "evidence": [ { "id": "A0AAA9SLN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIF14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8", "locus": { "chromosome": "16", "start_pos": 79210161, "end_pos": 79285049, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021874", "url": "https://www.ensembl.org/id/ENSBTAG00000021874" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021874", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021874", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22707", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22707", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G5E5S3", "url": "https://www.orthodb.org/?gene=G5E5S3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47117:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47117:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00498", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00498", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16183", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16183", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23313", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23313", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5625900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5625900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5S3", "url": "https://www.uniprot.org/uniprotkb/G5E5S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5S3-1", "url": "https://www.uniprot.org/uniprotkb/G5E5S3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASTAHSRNDSDLLGVPSSTKTSSLSVIPQGSKLKLHPRSDSSEGENDDPLLRSTSKVRDINSTYVISACKKTGDTPLLPNPVGRLTLQRRATRSKEPSLLGCESGDAGARTAGTCLALQRRTKTGCVEKWKGTQNVGGRTENSQPSPETGINVQTVNSDKNLPSVPLTPDPKDLEMKADGKCAVTRSALSGAGENVALESLRERTPAGSQSQTEAVRVGCVAVRPTESRLEIKVSGTRASHPRGAEKEAVKLPRRFESLEKRTPSKCISEPRSTPRRGVLQPRSPAAFVLRSRRPTLQVKQTPQSSLLASQRERSCENTFLLKEETALQITSAETEPLKVESSQVTVAVRVRPFSNREKREGAHQAVFLDGEEIAVEHPGTRQVYSFAYDLSFWSVDERHPRFASQMAVYQALAAPLLGQAFQGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFAEIAKKQTQEVSYHLEMSFFEVYNERIHDLLVCKGENGQRKQTLRVREHPASGPYVEGLSTNVVSSHSDIQVWLQLGNKQKATAATGMNDKSSRSHSVLTLVMTQAKTEFVEGEELDHRIRSRINLVDLAGSERCSATGTSGERLKEGVSINKSLLTLGKVISALSEQAGGRSVFIPYRESVLTWLLKESLSGNSKTAMVATVSPAGSSVEETLSTLRYAAQARSIVTAARVNEDLSAGLIRELKAEIEKLKAAQRSSQNIDPERYRLCRQEIASLRMKLHQQERDMANMQRMWKEKLEQAEKRKLQVTKELQKAGITFQMDNHLPNLVNLNEDPQLSEILLYMIKEGTTTVGKYRPSSSHDIQLSGVLIADDHCTITNSSGTVSIVPAGEAKTYVNGKLISEPTVLHHGDRVILGGDHYFRFNHPMEVQKGEQPPSRENPVSKRPEDFESAKNDLLTAQRLQLEAEIKEAQVRAKEEMMQGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEESQRKKIQEINNQKANHKIEELEEAKQRFEQEIHVNRKRLEMEALATKQALEDHRIRHAKILEALETEKQRIAQEVQSLQQSQSHRGKAFTVQPSWSSMKLSVMIQEANAISSRLNRNYVFGRHVVSDKGSSFDTCIRVRNLQLGVSTVWSLEKFESKLAAMKELYESHGSSQGEDVFCDPEDEWEPDITDVPVSSFSRRRSRSLMNNRRVSGCLHDIEAHAGQDLRSSGSAGLVGKSSPVYLESAEPFLPGICKELISSSLELLGQSDDEEGTVADSLMSNFLRIHDGVLAVSRAHEEQDEDSQCNLFADRANQSLTVQVASAFQQLTVLTAPWVSGVPLEAGRAALLAELRREVRTLGGRLQLFLQGCSSDISPMVKEAQKQVIQTVHRAVACVGRSVALGGDRLHFLESSAHGAAGLQDDFVGAVCDGVDLGIKSLLNSGIEKAKELEHELLRQSPQAEVTKQMKANALGLIESLGNLFAEWKTKSFRTQVQEENSEYEDLKKMINLAQEFFKLKCGLEQTIQIIISALRGHRGDVALLQDCVQRLCSSARGLHGDWGGCPEDSRAQAGHRELESCATSLLLGFEFEEGPGLWGPWETCDQGPRAAGQEQPGSDRPGPQRTRGVPKRVYELPGLALGGSEQDVLPTCEGAGEGSPPAREQ", "length": 1640, "header": "tr|A0AAA9SLN8-1|A0AAA9SLN8_BOVIN Isoform 1 of Kinesin-like protein KIF14 OS=Bos taurus OX=9913 GN=KIF14 PE=3 SV=1 CANONICAL=A0AAA9SLN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8/entry#A0AAA9SLN8-1", "sequence": { "sequence": "MSASTAHSRNDSDLLGVPSSTKTSSLSVIPQGSKLKLHPRSDSSEGENDDPLLRSTSKVRDINSTYVISACKKTGDTPLLPNPVGRLTLQRRATRSKEPSLLGCESGDAGARTAGTCLALQRRTKTGCVEKWKGTQNVGGRTENSQPSPETGINVQTVNSDKNLPSVPLTPDPKDLEMKADGKCAVTRSALSGAGENVALESLRERTPAGSQSQTEAVRVGCVAVRPTESRLEIKVSGTRASHPRGAEKEAVKLPRRFESLEKRTPSKCISEPRSTPRRGVLQPRSPAAFVLRSRRPTLQVKQTPQSSLLASQRERSCENTFLLKEETALQITSAETEPLKVESSQVTVAVRVRPFSNREKREGAHQAVFLDGEEIAVEHPGTRQVYSFAYDLSFWSVDERHPRFASQMAVYQALAAPLLGQAFQGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFAEIAKKQTQEVSYHLEMSFFEVYNERIHDLLVCKGENGQRKQTLRVREHPASGPYVEGLSTNVVSSHSDIQVWLQLGNKQKATAATGMNDKSSRSHSVLTLVMTQAKTEFVEGEELDHRIRSRINLVDLAGSERCSATGTSGERLKEGVSINKSLLTLGKVISALSEQAGGRSVFIPYRESVLTWLLKESLSGNSKTAMVATVSPAGSSVEETLSTLRYAAQARSIVTAARVNEDLSAGLIRELKAEIEKLKAAQRSSQNIDPERYRLCRQEIASLRMKLHQQERDMANMQRMWKEKLEQAEKRKLQVTKELQKAGITFQMDNHLPNLVNLNEDPQLSEILLYMIKEGTTTVGKYRPSSSHDIQLSGVLIADDHCTITNSSGTVSIVPAGEAKTYVNGKLISEPTVLHHGDRVILGGDHYFRFNHPMEVQKGEQPPSRENPVSKRPEDFESAKNDLLTAQRLQLEAEIKEAQVRAKEEMMQGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEESQRKKIQEINNQKANHKIEELEEAKQRFEQEIHVNRKRLEMEALATKQALEDHRIRHAKILEALETEKQRIAQEVQSLQQSQSHRGKAFTVQPSWSSMKLSVMIQEANAISSRLNRNYVFGRHVVSDKGSSFDTCIRVRNLQLGVSTVWSLEKFESKLAAMKELYESHGSSQGEDVFCDPEDEWEPDITDVPVSSFSRRRSRSLMNNRRVSGCLHDIEAHAGQDLRSSGSAGLVGKSSPVYLESAEPFLPGICKELISSSLELLGQSDDEEGTVADSLMSNFLRIHDGVLAVSRAHEEQDEDSQCNLFADRANQSLTVQVASAFQQLTVLTAPWVSGVPLEAGRAALLAELRREVRTLGGRLQLFLQGCSSDISPMVKEAQKQVIQTVHRAVACVGRSVALGGDRLHFLESSAHGAAGLQDDFVGAVCDGVDLGIKSLLNSGIEKAKELEHELLRQSPQAEVTKQMKANALGLIESLGNLFAEWKTKSFRTQVQEENSEYEDLKKMINLAQEFFKLKCGLEQTIQIIISALRGHRGDVALLQDCVQRLCSSARGLHGDWGGCPEDSRAQAGHRELESCATSLLLGFEFEEGPGLWGPWETCDQGPRAAGQEQPGSDRPGPQRTRGVPKRVYELPGLALGGSEQDVLPTCEGAGEGSPPAREQ", "length": 1640, "header": "tr|A0AAA9SLN8-1|A0AAA9SLN8_BOVIN Isoform 1 of Kinesin-like protein KIF14 OS=Bos taurus OX=9913 GN=KIF14 PE=3 SV=1 CANONICAL=A0AAA9SLN8-1" }, "locus": { "chromosome": "16", "start_pos": 79278728, "end_pos": 79211165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084832.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084832.1" } ] } }, { "isoform_ac": "G5E5S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8/entry#G5E5S3-1", "sequence": { "sequence": "MSASTAHSRNDSDLLGVPSSTKTSSLSVIPQGSKLKLHPRSDSSEGENDDPLLRSTSKVRDINSTYVISACKKTGDTPLLPNPVGRLTLQRRATRSKEPSLLGCESGDAGARTAGTCLALQRRTKTGCVEKWKGTQNVGGRTENSQPSPETGINVQTVNSDKNLPSVPLTPDPKDLEMKADGKCAVTRSALSGAGENVALESLRERTPAGSQSQTEAVRVGCVAVRPTESRLEIKVSGTRASHPRGAEKEAVKLPRRFESLEKRTPSKCISEPRSTPRRGVLQPRSPAAFVLRSRRPTLQVKQTPQSSLLASQRERSCENTFLLKEETALQITSAETEPLKVESSQVTVAVRVRPFSNREKREGAHQAVFLDGEEIAVEHPGTRQVYSFAYDLSFWSVDERHPRFASQMAVYQALAAPLLGQAFQGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFAEIAKKQTQEVSYHLEMSFFEVYNERIHDLLVCKGENGQRKQTLRVREHPASGPYVEGLSTNVVSSHSDIQVWLQLGNKQKATAATGMNDKSSRSHSVLTLVMTQAKTEFVEGEELDHRIRSRINLVDLAGSERCSATGTSGERLKEGVSINKSLLTLGKVISALSEQAGGRSVFIPYRESVLTWLLKESLSGNSKTAMVATVSPAGSSVEETLSTLRYAAQARSIVTAARVNEDLSAGLIRELKAEIEKLKAAQRSSQNIDPERYRLCRQEIASLRMKLHQQERDMANMQRMWKEKLEQAEKRKLQVTKELQKAGITFQMDNHLPNLVNLNEDPQLSEILLYMIKEGTTTVGKYRPSSSHDIQLSGVLIADDHCTITNSSGTVSIVPAGEAKTYVNGKLISEPTVLHHGDRVILGGDHYFRFNHPMEVQKGEQPPSRENPVSKRPEDFESAKNDLLTAQRLQLEAEIKEAQVRAKEEMMQGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEESQRKKIQEINNQKANHKIEELEEAKQRFEQEIHVNRKRLEMEALATKQALEDHRIRHAKILEALETEKQRIAQEVQSLQQSQSHRGKAFTVQPSWSSMKLSVMIQEANAISSRLNRNYVFGRHVVSDKGSSFDTCIRVRNLQLGVSTVWSLEKFESKLAAMKELYESHGSSQGEDVFCDPEDEWEPDITDVPVSSFSRRRSRSLMNNRRVSGCLHDIEAHAGQDLRSSGSAGLVGKSSPVYLESAEPFLPGICKELISSSLELLGQSDDEEGTVADSLMSNFLRIHDGVLAVSRAHEEQDEDSQCNLFADRANQSLTVQVASAFQQLTVLTAPWVSGVPLEAGRAALLAELRREVRTLGGRLQLFLQGCSSDISPMVKEAQKQVIQTVHRAVACVGRSVALGGDRLHFLESSAHGAAGLQDDFVGAVCDGVDLGIKSLLNSGIEKAKELEHELLRQSPQAEVTKQMKANALGLIESLGNLFAEWKTKSFRTQVQEENSEYEDLKKMINLAQEFFKLKCGLEQTIQIIISALRGHRGDVALLQDCVQRLCSSARGPPWRLGRVP", "length": 1541, "header": "tr|G5E5S3-1|G5E5S3_BOVIN Computationally mapped isoform of Kinesin-like protein KIF14 OS=Bos taurus OX=9913 GN=KIF14 PE=3 SV=3 CANONICAL=A0AAA9SLN8-1" }, "locus": { "chromosome": "16", "start_pos": 79278728, "end_pos": 79237766, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029161.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029161.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029161.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029161.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5625900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5625900", "resource": "Reactome", "description": "RHO GTPases activate CIT" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" }, { "id": "R-BTA-9696273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "resource": "Reactome", "description": "RND1 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "cerebellar Purkinje cell layer structural organization", "id": "GO:0021693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "cerebellar granular layer structural organization", "id": "GO:0021685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "regulation of cell maturation", "id": "GO:1903429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903429", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010389", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "hippocampus development", "id": "GO:0021766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021766", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "regulation of cell growth", "id": "GO:0001558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001558", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "mitotic metaphase chromosome alignment", "id": "GO:0007080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "regulation of myelination", "id": "GO:0031641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031641", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "cell proliferation in forebrain", "id": "GO:0021846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021846", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "positive regulation of cytokinesis", "id": "GO:0032467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032467", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "olfactory bulb development", "id": "GO:0021772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021772", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "plus-end-directed microtubule motor activity", "id": "GO:0008574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008574", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "spindle midzone", "id": "GO:0051233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051233", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1291, "end_pos": 1293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" }, { "id": "PS50006", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50006" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FHA", "eco_id": "ECO_0000259", "start_pos": 813, "end_pos": 864, "start_aa": "Thr", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SLN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN8" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 346, "end_pos": 689, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 1291, "end_pos": 1293 }, { "start_pos": 615, "end_pos": 617 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 842, "end_pos": 844 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLP4-1", "uniprot_ac": "A0AAA9SLP4", "uniprot_id": "A0AAA9SLP4_BOVIN", "mass": { "chemical_mass": 34625.0, "monoisotopic_mass": 34625.0 }, "refseq": {}, "gene_names": [ { "name": "PPP1R3E", "type": "recommended", "evidence": [ { "id": "A0AAA9SLP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 3E", "type": "synonym", "evidence": [ { "id": "A0AAA9SLP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R3E", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4", "locus": { "chromosome": "10", "start_pos": 21612728, "end_pos": 21607231, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037679", "url": "https://www.ensembl.org/id/ENSBTAG00000037679" } ] } } ], "crossref": [ { "id": "A0AAA9SLP4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037679", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037679", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527187", "url": "https://www.ncbi.nlm.nih.gov/gene/527187", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12307", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12307", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12307:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12307:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MV14", "url": "https://www.uniprot.org/uniprotkb/F1MV14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MV14-1", "url": "https://www.uniprot.org/uniprotkb/F1MV14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LQPIHTKAPSGILAGAHRLLQLAHSTAPFGGLSNQTKRDEKTEVQRSCALLKVTQLNSTRERAYYLSQRPSLGEEPEEEPSEGGTRLGARSRAPGPSRGRRARSAPAGGGGTRALRNHSPDTRKRVRFADALGLELAAVRRFRPGELPRVPRHVQVQLQRDALRHFAPCQPRARGLQEARAALEPASEPGFAARLQAQRICLERVEAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSQREAPAAYAGPAPPPPRADRFSFRLPAPPIGGSLLFALRYRVTGREFWDNNGGRDYALRGPEHPGSGGNAEPQGWIHFI", "length": 317, "header": "tr|A0AAA9SLP4-1|A0AAA9SLP4_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 3E OS=Bos taurus OX=9913 GN=PPP1R3E PE=4 SV=1 CANONICAL=A0AAA9SLP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4/entry#A0AAA9SLP4-1", "sequence": { "sequence": "LQPIHTKAPSGILAGAHRLLQLAHSTAPFGGLSNQTKRDEKTEVQRSCALLKVTQLNSTRERAYYLSQRPSLGEEPEEEPSEGGTRLGARSRAPGPSRGRRARSAPAGGGGTRALRNHSPDTRKRVRFADALGLELAAVRRFRPGELPRVPRHVQVQLQRDALRHFAPCQPRARGLQEARAALEPASEPGFAARLQAQRICLERVEAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSQREAPAAYAGPAPPPPRADRFSFRLPAPPIGGSLLFALRYRVTGREFWDNNGGRDYALRGPEHPGSGGNAEPQGWIHFI", "length": 317, "header": "tr|A0AAA9SLP4-1|A0AAA9SLP4_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 3E OS=Bos taurus OX=9913 GN=PPP1R3E PE=4 SV=1 CANONICAL=A0AAA9SLP4-1" }, "locus": { "chromosome": "10", "start_pos": 21611724, "end_pos": 21607749, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094830.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094830.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084837.1" } ] } }, { "isoform_ac": "A0AAA9TVY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4/entry#A0AAA9TVY3-1", "sequence": { "sequence": "SLGDEAELQEVKDSSERAYYLSQRPSLGEEPEEEPSEGGTRLGARSRAPGPSRGRRARSAPAGGGGTRALRNHSPDTRKRVRFADALGLELAAVRRFRPGELPRVPRHVQVQLQRDALRHFAPCQPRARGLQEARAALEPASEPGFAARLQAQRICLERVEAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSQREAPAAYAGPAPPPPRADRFSFRLPAPPIGGSLLFALRYRVTGREFWDNNGGRDYALRGPEHPGSGGNAEPQGWIHFI", "length": 272, "header": "tr|A0AAA9TVY3-1|A0AAA9TVY3_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 3E OS=Bos taurus OX=9913 GN=PPP1R3E PE=4 SV=1 CANONICAL=A0AAA9SLP4-1" }, "locus": { "chromosome": "10", "start_pos": 21611724, "end_pos": 21610388, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122184.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122184.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102781.1" } ] } }, { "isoform_ac": "F1MV14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4/entry#F1MV14-1", "sequence": { "sequence": "MRAVSADEKTEVQRSCALLKVTQLNSTRERAYYLSQRPSLGEEPEEEPSEGGTRLGARSRAPGPSRGRRARSAPAGGGGTRALRNHSPDTRKRVRFADALGLELAAVRRFRPGELPRVPRHVQVQLQRDALRHFAPCQPRARGLQEARAALEPASEPGFAARLQAQRICLERVEAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSQREAPAAYAGPAPPPPRADRFSFRLPAPPIGGSLLFALRYRVTGREFWDNNGGRDYALRGPEHPGSGGNAEPQGWIHFI", "length": 285, "header": "tr|F1MV14-1|A0AAA9SLP4_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 3E OS=Bos taurus OX=9913 GN=PPP1R3E PE=4 SV=4 CANONICAL=A0AAA9SLP4-1" }, "locus": { "chromosome": "10", "start_pos": 21611724, "end_pos": 21607430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052538.5", "url": "https://www.ensembl.org/id/ENSBTAT00000052538.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047874.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047874.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 112, "start_aa": "Thr", "end_pos": 112, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr112", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glycogen metabolic process", "id": "GO:0005977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "pmid": "" }, { "name": "regulation of glycogen biosynthetic process", "id": "GO:0005979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phosphoprotein phosphatase activity", "id": "GO:0004721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004721", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "pmid": "" }, { "name": "protein phosphatase 1 binding", "id": "GO:0008157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "pmid": "" }, { "name": "glycogen binding", "id": "GO:2001069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "protein phosphatase type 1 complex", "id": "GO:0000164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000164", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP4" }, { "id": "PS51159", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51159" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBM21", "eco_id": "ECO_0000259", "start_pos": 192, "end_pos": 297, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 112 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLP6-1", "uniprot_ac": "A0AAA9SLP6", "uniprot_id": "A0AAA9SLP6_BOVIN", "mass": { "chemical_mass": 66243.0, "monoisotopic_mass": 66243.0 }, "refseq": {}, "gene_names": [ { "name": "AAMP", "type": "recommended", "evidence": [ { "id": "A0AAA9SLP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ] } ], "protein_names": [ { "name": "Angio-associated migratory cell protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6#function" }, { "database": "UniProtKB", "id": "ARBA00059273", "url": "https://www.uniprot.org/uniprotkb/ARBA00059273#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AAMP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6", "locus": { "chromosome": "2", "start_pos": 106293608, "end_pos": 106301156, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003927", "url": "https://www.ensembl.org/id/ENSBTAG00000003927" } ] } } ], "crossref": [ { "id": "A0AAA9SLP6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLP6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19857", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19857", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19857:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19857:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFCRAFICFKRSLSTSRLKRKLKPQETNCFAQGQTANYPGLEPKPPEAQGSFPLHCDQKLQLPEAQAADPGELLFPGEPRKRARSLVSLLLGAESGWAEFGFSSPRLGLVSHFCLVIGDSAGPPLSLLVKRPSLSLPGSRLRLLPPGRRGSSSASSRRADSGRRLGPEKWVRRLRRMESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPADDLVQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPTGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNSIHVLKGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 611, "header": "tr|A0AAA9SLP6-1|A0AAA9SLP6_BOVIN Isoform 1 of Angio-associated migratory cell protein OS=Bos taurus OX=9913 GN=AAMP PE=4 SV=1 CANONICAL=A0AAA9SLP6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6/entry#A0AAA9SLP6-1", "sequence": { "sequence": "MFCRAFICFKRSLSTSRLKRKLKPQETNCFAQGQTANYPGLEPKPPEAQGSFPLHCDQKLQLPEAQAADPGELLFPGEPRKRARSLVSLLLGAESGWAEFGFSSPRLGLVSHFCLVIGDSAGPPLSLLVKRPSLSLPGSRLRLLPPGRRGSSSASSRRADSGRRLGPEKWVRRLRRMESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPADDLVQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPTGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNSIHVLKGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 611, "header": "tr|A0AAA9SLP6-1|A0AAA9SLP6_BOVIN Isoform 1 of Angio-associated migratory cell protein OS=Bos taurus OX=9913 GN=AAMP PE=4 SV=1 CANONICAL=A0AAA9SLP6-1" }, "locus": { "chromosome": "2", "start_pos": 106301113, "end_pos": 106294024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098891.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098891.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083603.1" } ] } }, { "isoform_ac": "A0AAF6YLU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6/entry#A0AAF6YLU7-1", "sequence": { "sequence": "MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPADDLVQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPTGDCKTFQGPNCPATCGRVLPDGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 407, "header": "tr|A0AAF6YLU7-1|A0AAF6YLU7_BOVIN Computationally mapped isoform of Angio associated migratory cell protein OS=Bos taurus OX=9913 GN=AAMP PE=4 SV=1 CANONICAL=A0AAA9SLP6-1" }, "locus": { "chromosome": "2", "start_pos": 106298458, "end_pos": 106294024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005126.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005126.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005126.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005126.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "smooth muscle cell migration", "id": "GO:0014909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLP6" }, { "id": "PF23098", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolar protein 10-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 411, "end_pos": 605, "start_aa": "Tyr", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLR3-1", "uniprot_ac": "A0AAA9SLR3", "uniprot_id": "A0AAA9SLR3_BOVIN", "mass": { "chemical_mass": 62334.0, "monoisotopic_mass": 62334.0 }, "refseq": {}, "gene_names": [ { "name": "RELA", "type": "recommended", "evidence": [ { "id": "A0AAA9SLR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ] } ], "protein_names": [ { "name": "RELA proto-onco, NF-kB subunit", "type": "synonym", "evidence": [ { "id": "A0AAA9SLR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RELA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3", "locus": { "chromosome": "29", "start_pos": 43830896, "end_pos": 43839652, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013895", "url": "https://www.ensembl.org/id/ENSBTAG00000013895" } ] } } ], "crossref": [ { "id": "A0AAA9SLR3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01177", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01177", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07885", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07885", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24169", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24169", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24169:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24169:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00554", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00554", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R8C2", "url": "https://www.uniprot.org/uniprotkb/F6R8C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R8C2-1", "url": "https://www.uniprot.org/uniprotkb/F6R8C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALGPRGPRREAPLRLLTLHLFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLRLAPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPGLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTDPRPPTRRIAVPNRGSASIPKPAPQPYSFTPSLSTINFEEFSPMVFPSGQIPSQTSALAPAPTPVLTQTQVLAPAPAPAPGMASTLAQALAPGLAQAVTPPAPRTNQTGEGTLTEALLQLQFDTDEDLGALLGNNTDPAVFTDLASVDNSEFQQLLNQGVPMGPHTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGPPGLTNGLLSGDEDFSSIADVDFSALLSQISS", "length": 569, "header": "tr|A0AAA9SLR3-1|A0AAA9SLR3_BOVIN Isoform 1 of RELA proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=RELA PE=4 SV=1 CANONICAL=A0AAA9SLR3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3/entry#A0AAA9SLR3-1", "sequence": { "sequence": "MAALGPRGPRREAPLRLLTLHLFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLRLAPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPGLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTDPRPPTRRIAVPNRGSASIPKPAPQPYSFTPSLSTINFEEFSPMVFPSGQIPSQTSALAPAPTPVLTQTQVLAPAPAPAPGMASTLAQALAPGLAQAVTPPAPRTNQTGEGTLTEALLQLQFDTDEDLGALLGNNTDPAVFTDLASVDNSEFQQLLNQGVPMGPHTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGPPGLTNGLLSGDEDFSSIADVDFSALLSQISS", "length": 569, "header": "tr|A0AAA9SLR3-1|A0AAA9SLR3_BOVIN Isoform 1 of RELA proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=RELA PE=4 SV=1 CANONICAL=A0AAA9SLR3-1" }, "locus": { "chromosome": "29", "start_pos": 43839420, "end_pos": 43831681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105330.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105330.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083638.1" } ] } }, { "isoform_ac": "A0AAA9SQ62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3/entry#A0AAA9SQ62-1", "sequence": { "sequence": "MDDLFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLRLAPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPGLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTDPRPPTRRIAVPNRGSASIPKPGEDFLSHRNCRLKSVQLGSGEDADSRALQTWG", "length": 376, "header": "tr|A0AAA9SQ62-1|A0AAA9SQ62_BOVIN Computationally mapped isoform of RELA proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=RELA PE=4 SV=1 CANONICAL=A0AAA9SLR3-1" }, "locus": { "chromosome": "29", "start_pos": 43839453, "end_pos": 43832818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088463.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088463.1" } ] } }, { "isoform_ac": "F6R8C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3/entry#F6R8C2-1", "sequence": { "sequence": "MDEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLRLAPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPGLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTDPRPPTRRIAVPNRGSASIPKPAPQPYSFTPSLSTINFEEFSPMVFPSGQIPSQTSALAPAPTPVLTQTQVLAPAPAPAPGMASTLAQALAPGLAQAVTPPAPRTNQTGEGTLTEALLQLQFDTDEDLGALLGNNTDPAVFTDLASVDNSEFQQLLNQGVPMGPHTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGPPGLTNGLLSGDEDFSSIADVDFSALLSQISS", "length": 542, "header": "tr|F6R8C2-1|F6R8C2_BOVIN Computationally mapped isoform of RELA proto-onco, NF-kB subunit OS=Bos taurus OX=9913 GN=RELA PE=4 SV=1 CANONICAL=A0AAA9SLR3-1" }, "locus": { "chromosome": "29", "start_pos": 43839453, "end_pos": 43831681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018453.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018453.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018453.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018453.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 403, "start_aa": "Thr", "end_pos": 403, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr403", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 439, "start_aa": "Thr", "end_pos": 439, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr439", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 534, "start_aa": "Thr", "end_pos": 534, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr534", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "NF-kappaB p50/p65 complex", "id": "GO:0035525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 19, "go_terms": [ { "name": "phosphate ion binding", "id": "GO:0042301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "NF-kappaB binding", "id": "GO:0051059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "RNA polymerase II core promoter sequence-specific DNA binding", "id": "GO:0000979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "peptide binding", "id": "GO:0042277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "general transcription initiation factor binding", "id": "GO:0140296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "actinin binding", "id": "GO:0042805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "ankyrin repeat binding", "id": "GO:0071532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071532", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 37, "go_terms": [ { "name": "cellular response to angiotensin", "id": "GO:1904385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904385", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "interleukin-1-mediated signaling pathway", "id": "GO:0070498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070498", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "positive regulation of leukocyte adhesion to vascular endothelial cell", "id": "GO:1904996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904996", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "liver development", "id": "GO:0001889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "positive regulation of vascular endothelial growth factor production", "id": "GO:0010575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010575", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "negative regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "negative regulation of cytokine production involved in inflammatory response", "id": "GO:1900016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900016", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "canonical NF-kappaB signal transduction", "id": "GO:0007249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "non-canonical NF-kappaB signal transduction", "id": "GO:0038061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038061", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "toll-like receptor TLR6:TLR2 signaling pathway", "id": "GO:0038124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cellular response to lipoteichoic acid", "id": "GO:0071223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cellular response to peptidoglycan", "id": "GO:0071224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "vascular endothelial growth factor signaling pathway", "id": "GO:0038084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038084", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "toll-like receptor 4 signaling pathway", "id": "GO:0034142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034142", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "response to UV-B", "id": "GO:0010224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cellular response to nicotine", "id": "GO:0071316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071316", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "positive regulation of miRNA transcription", "id": "GO:1902895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902895", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "negative regulation of protein sumoylation", "id": "GO:0033234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033234", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "cellular response to interleukin-6", "id": "GO:0071354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071354", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "defense response to tumor cell", "id": "GO:0002357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "postsynapse to nucleus signaling pathway", "id": "GO:0099527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "prolactin signaling pathway", "id": "GO:0038161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" }, { "name": "regulation of multicellular organismal process", "id": "GO:0051239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051239", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR3" }, { "id": "PS50254", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50254" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RHD", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 208, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 403, 439, 534 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 446, "end_pos": 448 }, { "start_pos": 474, "end_pos": 476 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLS3-1", "uniprot_ac": "A0AAA9SLS3", "uniprot_id": "A0AAA9SLS3_BOVIN", "mass": { "chemical_mass": 2868.0, "monoisotopic_mass": 2868.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SLS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLS3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SLS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAWRQRRLRQSARPALNEQGWD", "length": 24, "header": "tr|A0AAA9SLS3-1|A0AAA9SLS3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SLS3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS3/entry#A0AAA9SLS3-1", "sequence": { "sequence": "MAAAWRQRRLRQSARPALNEQGWD", "length": 24, "header": "tr|A0AAA9SLS3-1|A0AAA9SLS3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SLS3-1" }, "locus": { "chromosome": "14", "start_pos": 54861763, "end_pos": 54861692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102780.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102780.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086203.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086203.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLU0-1", "uniprot_ac": "A0AAA9SLU0", "uniprot_id": "A0AAA9SLU0_BOVIN", "mass": { "chemical_mass": 13100.0, "monoisotopic_mass": 13100.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLU0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19367:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19367:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLSSLPWVFLAFIFSGSSVAQRVAQDQPDISSQVGEVVTLRCQYETRLSSFRIFWYKQLPSGEMIYLIGQVSSSQKARDGRYTTDLQISRKSISLTISDLQLEDSAKYFCAVWE", "length": 115, "header": "tr|A0AAA9SLU0-1|A0AAA9SLU0_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SLU0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0/entry#A0AAA9SLU0-1", "sequence": { "sequence": "MLLSSLPWVFLAFIFSGSSVAQRVAQDQPDISSQVGEVVTLRCQYETRLSSFRIFWYKQLPSGEMIYLIGQVSSSQKARDGRYTTDLQISRKSISLTISDLQLEDSAKYFCAVWE", "length": 115, "header": "tr|A0AAA9SLU0-1|A0AAA9SLU0_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SLU0-1" }, "locus": { "chromosome": "NKLS02001214.1", "start_pos": 110580, "end_pos": 110121, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135726.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135726.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087319.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087319.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 115, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLU4-1", "uniprot_ac": "A0AAA9SLU4", "uniprot_id": "A0AAA9SLU4_BOVIN", "mass": { "chemical_mass": 33698.0, "monoisotopic_mass": 33698.0 }, "refseq": {}, "gene_names": [ { "name": "CDPF1", "type": "recommended", "evidence": [ { "id": "A0AAA9SLU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4" } ] } ], "protein_names": [ { "name": "Cysteine-rich DPF motif domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SLU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDPF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4", "locus": { "chromosome": "5", "start_pos": 116513933, "end_pos": 116523076, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008065", "url": "https://www.ensembl.org/id/ENSBTAG00000008065" } ] } } ], "crossref": [ { "id": "A0AAA9SLU4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLU4", "database": "AlphaFoldDB", "categories": [] }, { "id": "537366", "url": "https://www.ncbi.nlm.nih.gov/gene/537366", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31849:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31849:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRX3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGIQSCLFATPTTVAPPGSSVHGNSLGKNTGVGYHALLQGTLPNPGIEPRFPASRAQSSRSESPLKPSGRRKGSPPRSPAPPHPPRRRPGHAVAGAGAGPRTRPGLGLAAAEAAEMACETERTPLGVFKCQLCALTAPYSYQGRQPPDSQSVVLLEESYVMRDPFTPDKGRFLVVGSRNAVYSTPRDFASPVSRTTWMLSLRKFSKTWRKEKSPSRGLPASAVLNHECSRVPGPQRCSPRACGHAGFRGPGQRRGRDGATVPAFFLGHWEPCLQPGGAGVCLQQHQGQEPAETAPTGRPQTPALRDRSPPPAQPPP", "length": 317, "header": "tr|A0AAA9SLU4-1|A0AAA9SLU4_BOVIN Isoform 1 of Cysteine-rich DPF motif domain-containing protein 1 OS=Bos taurus OX=9913 GN=CDPF1 PE=3 SV=1 CANONICAL=A0AAA9SLU4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4/entry#A0AAA9SLU4-1", "sequence": { "sequence": "MKGIQSCLFATPTTVAPPGSSVHGNSLGKNTGVGYHALLQGTLPNPGIEPRFPASRAQSSRSESPLKPSGRRKGSPPRSPAPPHPPRRRPGHAVAGAGAGPRTRPGLGLAAAEAAEMACETERTPLGVFKCQLCALTAPYSYQGRQPPDSQSVVLLEESYVMRDPFTPDKGRFLVVGSRNAVYSTPRDFASPVSRTTWMLSLRKFSKTWRKEKSPSRGLPASAVLNHECSRVPGPQRCSPRACGHAGFRGPGQRRGRDGATVPAFFLGHWEPCLQPGGAGVCLQQHQGQEPAETAPTGRPQTPALRDRSPPPAQPPP", "length": 317, "header": "tr|A0AAA9SLU4-1|A0AAA9SLU4_BOVIN Isoform 1 of Cysteine-rich DPF motif domain-containing protein 1 OS=Bos taurus OX=9913 GN=CDPF1 PE=3 SV=1 CANONICAL=A0AAA9SLU4-1" }, "locus": { "chromosome": "5", "start_pos": 116522877, "end_pos": 116514149, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084908.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084908.1" } ] } }, { "isoform_ac": "A0AAF6YRX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4/entry#A0AAF6YRX3-1", "sequence": { "sequence": "MPGRSAACCMDSGRRSLWEKIVPELKRPHMPRKMACETERTPLGVFKCQLCALTAPYSYQGRQPPDSQSVVLLEESYVMRDPFTPDKGRFLVVGSRCSMCGRLVCVGPECSLFYSKRFCLPCVQDNVDAFPQEIQQDLEKRKVPFTRPASQRSS", "length": 154, "header": "tr|A0AAF6YRX3-1|A0AAF6YRX3_BOVIN Computationally mapped isoform of Cysteine-rich DPF motif domain-containing protein 1 OS=Bos taurus OX=9913 GN=CDPF1 PE=3 SV=1 CANONICAL=A0AAA9SLU4-1" }, "locus": { "chromosome": "5", "start_pos": 116521840, "end_pos": 116514426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010609.4", "url": "https://www.ensembl.org/id/ENSBTAT00000010609.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010609.3", "url": "https://www.ensembl.org/id/ENSBTAP00000010609.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU4" }, { "id": "PF10170", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10170" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cysteine-rich DPF motif", "eco_id": "ECO_0000259", "start_pos": 129, "end_pos": 181, "start_aa": "Phe", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLU8-1", "uniprot_ac": "A0AAA9SLU8", "uniprot_id": "A0AAA9SLU8_BOVIN", "mass": { "chemical_mass": 5443.0, "monoisotopic_mass": 5443.0 }, "refseq": {}, "gene_names": [ { "name": "KRTAP19-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SLU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8" } ] } ], "protein_names": [ { "name": "Keratin associated protein 19-2", "type": "synonym", "evidence": [ { "id": "A0AAA9SLU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8#function" }, { "database": "UniProtKB", "id": "ARBA00003327", "url": "https://www.uniprot.org/uniprotkb/ARBA00003327#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTAP19-2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8", "locus": { "chromosome": "1", "start_pos": 5463656, "end_pos": 5457770, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057618", "url": "https://www.ensembl.org/id/ENSBTAG00000057618" } ] } } ], "crossref": [ { "id": "A0AAA9SLU8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR021743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR38140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR38140:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38140:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFGRGCGCGSFRLLGFGSGFGGYRCGSGFGSFGSGCCHPLFFRRCGFSSFY", "length": 52, "header": "tr|A0AAA9SLU8-1|A0AAA9SLU8_BOVIN Isoform 1 of Keratin associated protein 19-2 OS=Bos taurus OX=9913 GN=KRTAP19-2 PE=3 SV=2 CANONICAL=A0AAA9SLU8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8/entry#A0AAA9SLU8-1", "sequence": { "sequence": "MGFGRGCGCGSFRLLGFGSGFGGYRCGSGFGSFGSGCCHPLFFRRCGFSSFY", "length": 52, "header": "tr|A0AAA9SLU8-1|A0AAA9SLU8_BOVIN Isoform 1 of Keratin associated protein 19-2 OS=Bos taurus OX=9913 GN=KRTAP19-2 PE=3 SV=2 CANONICAL=A0AAA9SLU8-1" }, "locus": { "chromosome": "1", "start_pos": 5463653, "end_pos": 5457770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114424.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114424.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086241.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086241.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLW0-1", "uniprot_ac": "A0AAA9SLW0", "uniprot_id": "A0AAA9SLW0_BOVIN", "mass": { "chemical_mass": 35923.0, "monoisotopic_mass": 35923.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Peptidase S1 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLW0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046965", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046965", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3MYJ4", "url": "https://www.orthodb.org/?gene=G3MYJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253:SF144", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253:SF144", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYJ4", "url": "https://www.uniprot.org/uniprotkb/G3MYJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYJ4-1", "url": "https://www.uniprot.org/uniprotkb/G3MYJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPREEAPHSACLSTLPPGSWPWVPHQGPLCAAGQGSLMAPFLGFPDPNLGREQHGTVGVHDAPPGRWPWQASLRRHSKEREQWEHVCGGFLVHLQWVLTAAHCTGRWVTLLAAPLAGEGSGGGADIALLRLEAPVTLSPHVQVVSLPPASLRVPEKKMCWVTGWGDVRLGGPLRPPHHLQEAEVPVVGNEVCNRHYQNSSADAARQIFKDNMLCAGSEGRDSCQGDSGGPLVCSWNDTWVQVGIVSWGDICGHRDLPGVYTRVTSYVLALPIPLPLALGGRDSEKPRALLSPGSVVAPGLLLTLCLPLNSEKPAPDCGLGLWRCACWREPCGGP", "length": 335, "header": "tr|A0AAA9SLW0-1|A0AAA9SLW0_BOVIN Isoform 1 of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SLW0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0/entry#A0AAA9SLW0-1", "sequence": { "sequence": "MHPREEAPHSACLSTLPPGSWPWVPHQGPLCAAGQGSLMAPFLGFPDPNLGREQHGTVGVHDAPPGRWPWQASLRRHSKEREQWEHVCGGFLVHLQWVLTAAHCTGRWVTLLAAPLAGEGSGGGADIALLRLEAPVTLSPHVQVVSLPPASLRVPEKKMCWVTGWGDVRLGGPLRPPHHLQEAEVPVVGNEVCNRHYQNSSADAARQIFKDNMLCAGSEGRDSCQGDSGGPLVCSWNDTWVQVGIVSWGDICGHRDLPGVYTRVTSYVLALPIPLPLALGGRDSEKPRALLSPGSVVAPGLLLTLCLPLNSEKPAPDCGLGLWRCACWREPCGGP", "length": 335, "header": "tr|A0AAA9SLW0-1|A0AAA9SLW0_BOVIN Isoform 1 of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SLW0-1" }, "locus": { "chromosome": "25", "start_pos": 1025795, "end_pos": 1020527, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091893.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091893.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087334.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087334.1" } ] } }, { "isoform_ac": "G3MYJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0/entry#G3MYJ4-1", "sequence": { "sequence": "FRARGASCLCPSVSPESLSLSPAPATQMPLYQLCAAGQGSLMAPFLGFPDPNLGREQHGTVGVHDAPPGRWPWQASLRRHSKEREQWEHVCGGFLVHLQWVLTAAHCTGRWVTLLAAPLAGEGSGDRLMKVTEIIPHPDYNHLLSAKGGADIALLRLEAPVTLSPHVQVVSLPPASLRVPEKKMCWVTGWGDVRLGGPLRPPHHLQEAEVPVVGNEVCNRHYQNSSADAARQIFKDNMLCAGSEGRDSCQGDSGGPLVCSWNDTWVQVGIVSWGDICGHRDLPGVYTRPSHPLSSPSPPVPNPSQRQSLFQ", "length": 311, "header": "tr|G3MYJ4-1|G3MYJ4_BOVIN Computationally mapped isoform of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=3 CANONICAL=A0AAA9SLW0-1" }, "locus": { "chromosome": "25", "start_pos": 1025668, "end_pos": 1020084, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063348.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063348.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054627.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054627.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLW0" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 268, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 199, "end_pos": 201 }, { "start_pos": 237, "end_pos": 239 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLZ9-1", "uniprot_ac": "A0AAA9SLZ9", "uniprot_id": "A0AAA9SLZ9_BOVIN", "mass": { "chemical_mass": 64339.0, "monoisotopic_mass": 64339.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF768", "type": "recommended", "evidence": [ { "id": "A0AAA9SLZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ] } ], "protein_names": [ { "name": "Zinc finger protein 768", "type": "recommended", "evidence": [ { "id": "A0AAA9SLZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity. Required for cell homeostasis. May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BLD0", "url": "https://www.uniprot.org/uniprotkb/E1BLD0#function" }, { "database": "UniProtKB", "id": "ARBA00054040", "url": "https://www.uniprot.org/uniprotkb/ARBA00054040#function" }, { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9#function" }, { "database": "UniProtKB", "id": "A0AAA9TC05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC05#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLZ9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000043974", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043974", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100847165", "url": "https://www.ncbi.nlm.nih.gov/gene/100847165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847165", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SPQFEML", "url": "https://omabrowser.org/oma/group/SPQFEML/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BLD0", "url": "https://www.orthodb.org/?gene=E1BLD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF120", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF120", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLD0", "url": "https://www.uniprot.org/uniprotkb/E1BLD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLD0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAGKALKVQFREDERRQDLPRTPPGGTSGARRRWNRPVHPATNQKGNMSENEEEEISQQEGTGDYEVEEIAFGLEPQSPGFGPQSPEFEPQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDSQSPDFEPQSPRYEPQSPGYEPKSPGYEPRSPGYEPKSPGYEPRSPGYESQSPKYGTQSPEYEPQNPEFKTQSPEFEAESSKFQEGAEMLLNPEEKNPLSIPLGVHPLDAFTQGFGEQPAGGMPLGPPFEMPTGALLAPPQFEMLQNPLGLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 578, "header": "tr|A0AAA9SLZ9-1|A0AAA9SLZ9_BOVIN Isoform 1 of Zinc finger protein 768 OS=Bos taurus OX=9913 GN=ZNF768 PE=3 SV=1 CANONICAL=A0AAA9SLZ9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9/entry#A0AAA9SLZ9-1", "sequence": { "sequence": "MRAGKALKVQFREDERRQDLPRTPPGGTSGARRRWNRPVHPATNQKGNMSENEEEEISQQEGTGDYEVEEIAFGLEPQSPGFGPQSPEFEPQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDSQSPDFEPQSPRYEPQSPGYEPKSPGYEPRSPGYEPKSPGYEPRSPGYESQSPKYGTQSPEYEPQNPEFKTQSPEFEAESSKFQEGAEMLLNPEEKNPLSIPLGVHPLDAFTQGFGEQPAGGMPLGPPFEMPTGALLAPPQFEMLQNPLGLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 578, "header": "tr|A0AAA9SLZ9-1|A0AAA9SLZ9_BOVIN Isoform 1 of Zinc finger protein 768 OS=Bos taurus OX=9913 GN=ZNF768 PE=3 SV=1 CANONICAL=A0AAA9SLZ9-1" }, "locus": { "chromosome": "25", "start_pos": 26713638, "end_pos": 26710404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133605.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133605.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087377.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087377.1" } ] } }, { "isoform_ac": "A0AAA9TC05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9/entry#A0AAA9TC05-1", "sequence": { "sequence": "MSENEEEEISQQEGTGDYEVEEIAFGLEPQSPGFGPQSPEFEPQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDSQSPDFEPQSPRYEPQSPGYEPKSPGYEPRSPGYEPKSPGYEPRSPGYESQSPKYGTQSPEYEPQNPEFKTQSPEFEAESSKFQEGAEMLLNPEEKNPLSIPLGVHPLDAFTQGFGEQPAGGMPLGPPFEMPTGALLAPPQFEMLQNPLGLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 530, "header": "tr|A0AAA9TC05-1|A0AAA9TC05_BOVIN Computationally mapped isoform of Zinc finger protein 768 OS=Bos taurus OX=9913 GN=ZNF768 PE=3 SV=1 CANONICAL=A0AAA9SLZ9-1" }, "locus": { "chromosome": "25", "start_pos": 26711993, "end_pos": 26710404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095575.1" } ] } }, { "isoform_ac": "E1BLD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9/entry#E1BLD0-1", "sequence": { "sequence": "MEREASPWGLEPRDMQSPDEMGSPEGSLKGNMSENEEEEISQQEGTGDYEVEEIAFGLEPQSPGFGPQSPEFEPQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDSQSPDFEPQSPRYEPQSPGYEPKSPGYEPRSPGYEPKSPGYEPRSPGYESQSPKYGTQSPEYEPQNPEFKTQSPEFEAESSKFQEGAEMLLNPEEKNPLSIPLGVHPLDAFTQGFGEQPAGGMPLGPPFEMPTGALLAPPQFEMLQNPLGLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 561, "header": "tr|E1BLD0-1|E1BLD0_BOVIN Computationally mapped isoform of Zinc finger protein 768 OS=Bos taurus OX=9913 GN=ZNF768 PE=3 SV=3 CANONICAL=A0AAA9SLZ9-1" }, "locus": { "chromosome": "25", "start_pos": 26712376, "end_pos": 26710404, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061583.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061583.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053794.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053794.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100847165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847165", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZGK0-1", "protein_name": "Zinc finger protein 768", "gene_name": "Zfp768", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEREASSWGLEPGDVHSPDAMGSPEGSLKGNTSENEEGEISQEGNGDYEVEEIPFGLEPQSPGFEPQSPEFESQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDPQSPEFESQSSRYEPQSPGYDPKSPGYEPGSPRYEPKSPGYGSKSPEFESQSPGCESQSPGYEPQNSGDEVRNSEFKTHSPEFETQSSKFQEGAEMLLNPEEKNPLNIPLGVHPLDSFTQGFGEQPTGALPLGAPFDMPSGALLATPQFEMLQNPLNLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 567 }, "evidence": [ { "id": "A0AAA9SLZ9", "url": "https://omabrowser.org/oma/group/A0AAA9SLZ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LUL2-1", "protein_name": "Zinc finger protein 768", "gene_name": "ZNF768", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEREASPWGLEPQDVQSRDEMGSPEGSLKGNMSENEEEEISQQEGTGDYEVEEIPFGLEPQSPGFGSQSPEFEPQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDSQSPDFESQSPGYEPKSPGYEPKSPGYEPRSPGYEPKSPGYEPGSPGYESQSSRYESQSPGYEPQNPEFKTQSPEFEAQSSKFQEGADMLLNSEEKNPLSIPLGVHPLDSFTQGFEEQPTGGLPLGPPFEMPTGALLAPPQFEMLQNPLGLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 561 }, "evidence": [ { "id": "A0AAA9SLZ9", "url": "https://omabrowser.org/oma/group/A0AAA9SLZ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8R0T2-1", "protein_name": "Zinc finger protein 768", "gene_name": "Znf768", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEREASSWGLESRDVHSPNAVGSPEGSLKDPAGNTSENEEGEISQREGNGDYEVEEIPFGLEPQSPEFEPQSPEFESQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESDPQSPEFESQSPKYEPRSPGCHPRSPGCEPGSPRYEPKSPGYGSKSPEFESQSPGYESQSPGYEPQNSGDGVQNSEFKTHSPEFETQSSKFQEGAEMPLSPEEKNPLSISLGVHPLDSFTQGFGEQPTGALPPFDMPSGALLAAPQFEMLQNPLNLTGTLRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 568 }, "evidence": [ { "id": "A0AAA9SLZ9", "url": "https://omabrowser.org/oma/group/A0AAA9SLZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H5H4-1", "protein_name": "Zinc finger protein 768", "gene_name": "ZNF768", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEREALPWGLEPQDVQSSDEMRSPEGYLRGNMSENEEEEISQQEGSGDYEVEEIPFGLEPQSPGFEPQSPEFEPQSPRFEPESPGFESRSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRYESQNTELKTQSPEFEAQSSKFQEGAEMLLNPEEKSPLNISVGVHPLDSFTQGFGEQPTGDLPIGPPFEMPTGALLSTPQFEMLQNPLGLTGALRGPGRRGGRARGGQGPRPNICGICGKSFGRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRHQRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCTECGKCYSQNSSLRSHQRVHTGQRPFSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKTFNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERPYKCDDCGKAFSQSSDLIRHQRTHAAGRR", "length": 540 }, "evidence": [ { "id": "A0AAA9SLZ9", "url": "https://omabrowser.org/oma/group/A0AAA9SLZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLZ9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 299, "end_pos": 326, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 423, "end_pos": 425 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 505, "end_pos": 507 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM19-1", "uniprot_ac": "A0AAA9SM19", "uniprot_id": "A0AAA9SM19_BOVIN", "mass": { "chemical_mass": 102162.0, "monoisotopic_mass": 102162.0 }, "refseq": { "ac": "XP_015313789", "name": "zinc finger protein 665 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313789" }, "gene_names": [ { "name": "LOC787812", "type": "recommended", "evidence": [ { "id": "A0AAA9SM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ] }, { "name": "LOC787812", "type": "synonym", "evidence": [ { "id": "XP_015313789", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313789" } ] } ], "protein_names": [ { "name": "Zinc finger protein 665", "type": "recommended", "evidence": [ { "id": "A0AAA9SM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 665 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015313789", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313789" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC787812", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19", "locus": {} } ], "crossref": [ { "id": "A0AAA9SM19", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM19", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787812", "url": "https://www.ncbi.nlm.nih.gov/gene/787812", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787812", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787812", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015313789", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313789", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALSQTQLTVEDVDIKFTPEEWECLDPAQRALYQDVMVETYRNLLSVDVSRIHMTMKLQAKGNNGKGEIFQRVMFGRAKTHEIKDYFLRNIQETVRGFENLWTDDERRDNGIFISYIKNLTDGRDHQSRNDAGDKPVERLGSSFHDELQMLQSEGTIFECSPVVTNINSSPLGLPTQRTRRVRKGICHKRESAPMHPSKQAPDQEGHKKKSYKSNECGITILQDSELTRHQKIHTGRKPYKADVYGKAFNENKSLAVHRTNHTGEKPYKCDVCSHSFKRNSALQIHLRVHTGERPYKCDVCGHSFKRNTALQIHLRVHTGERPYKCDVCGHTFKRNAALQIHLRVHTGERPYKCDVCGHSFKHQTHLQNHGRTHTGEKPYKCDICGRGYPRKAQLGIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDLCGQAFTRKESHTLHQILHTGEKPYKCDVCGRGYTRSRQLAIHQRVHTGEKPYKCDVCGHGYPQQSQLVIHQIVHTGENPYKCDICGCGFTGKRRLRIHRRIHPEVKSYKCNSCGKLFFALSSLNKHQEVQTDEKASKCNLCGKMFTSRCYLAVHQRSHTGEKPYKCDVCGKAFTWKQSHALHQILHSGEKPYKCDVCGCGYTRKSHLEIHCRVHTGEKPYKCDVCGKAFTRKDSCTLHQIIHTGEKPYKCDICGRGYTRKSQLGIHRRIHMRIHTGENSYKCAVCGRGFTEKRQLGSHWRIHTEEKPFKCNSCDKRFLAWSSLNTHQAVHTDEKAHKCTFCGKVFSSRCYLAVHQRIHTGEKPYKCDVCGRGYTRSRQLAIHQRVHTGEKHYKCNVCGKAFRVNGSLTSHRKIHSGEKLPGASTGVPTHDKVMWESSGGQGEPELEECPSGPA", "length": 893, "header": "tr|A0AAA9SM19-1|A0AAA9SM19_BOVIN Isoform 1 of Zinc finger protein 665 OS=Bos taurus OX=9913 GN=LOC787812 PE=3 SV=1 CANONICAL=A0AAA9SM19-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19/entry#A0AAA9SM19-1", "sequence": { "sequence": "MALSQTQLTVEDVDIKFTPEEWECLDPAQRALYQDVMVETYRNLLSVDVSRIHMTMKLQAKGNNGKGEIFQRVMFGRAKTHEIKDYFLRNIQETVRGFENLWTDDERRDNGIFISYIKNLTDGRDHQSRNDAGDKPVERLGSSFHDELQMLQSEGTIFECSPVVTNINSSPLGLPTQRTRRVRKGICHKRESAPMHPSKQAPDQEGHKKKSYKSNECGITILQDSELTRHQKIHTGRKPYKADVYGKAFNENKSLAVHRTNHTGEKPYKCDVCSHSFKRNSALQIHLRVHTGERPYKCDVCGHSFKRNTALQIHLRVHTGERPYKCDVCGHTFKRNAALQIHLRVHTGERPYKCDVCGHSFKHQTHLQNHGRTHTGEKPYKCDICGRGYPRKAQLGIHQRVHTGEKPYKCDVCGKAFTRKESHALHQILHTGEKPYKCDLCGQAFTRKESHTLHQILHTGEKPYKCDVCGRGYTRSRQLAIHQRVHTGEKPYKCDVCGHGYPQQSQLVIHQIVHTGENPYKCDICGCGFTGKRRLRIHRRIHPEVKSYKCNSCGKLFFALSSLNKHQEVQTDEKASKCNLCGKMFTSRCYLAVHQRSHTGEKPYKCDVCGKAFTWKQSHALHQILHSGEKPYKCDVCGCGYTRKSHLEIHCRVHTGEKPYKCDVCGKAFTRKDSCTLHQIIHTGEKPYKCDICGRGYTRKSQLGIHRRIHMRIHTGENSYKCAVCGRGFTEKRQLGSHWRIHTEEKPFKCNSCDKRFLAWSSLNTHQAVHTDEKAHKCTFCGKVFSSRCYLAVHQRIHTGEKPYKCDVCGRGYTRSRQLAIHQRVHTGEKHYKCNVCGKAFRVNGSLTSHRKIHSGEKLPGASTGVPTHDKVMWESSGGQGEPELEECPSGPA", "length": 893, "header": "tr|A0AAA9SM19-1|A0AAA9SM19_BOVIN Isoform 1 of Zinc finger protein 665 OS=Bos taurus OX=9913 GN=LOC787812 PE=3 SV=1 CANONICAL=A0AAA9SM19-1" }, "locus": { "chromosome": "18", "start_pos": 59247833, "end_pos": 59233182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083788.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787812", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787812", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 844, "end_pos": 846, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 239, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM19" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 83, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 168, "end_pos": 170 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 844, "end_pos": 846 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM20-1", "uniprot_ac": "A0AAA9SM20", "uniprot_id": "A0AAA9SM20_BOVIN", "mass": { "chemical_mass": 27882.0, "monoisotopic_mass": 27882.0 }, "refseq": { "ac": "NP_001179546", "name": "acyl-coenzyme A thioesterase THEM5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179546" }, "gene_names": [ { "name": "THEM5", "type": "recommended", "evidence": [ { "id": "A0AAA9SM20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20" } ] }, { "name": "THEM5", "type": "synonym", "evidence": [ { "id": "NP_001179546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179546" } ] } ], "protein_names": [ { "name": "Thioesterase superfamily member 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SM20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20/entry#names_and_taxonomy" } ] }, { "name": "acyl-coenzyme A thioesterase THEM5", "type": "synonym", "evidence": [ { "id": "NP_001179546", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179546" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THEM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20", "locus": { "chromosome": "3", "start_pos": 18933048, "end_pos": 18922110, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000690", "url": "https://www.ensembl.org/id/ENSBTAG00000000690" } ] } } ], "crossref": [ { "id": "A0AAA9SM20", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000690", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000690", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03443", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03443", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525765", "url": "https://www.ncbi.nlm.nih.gov/gene/525765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525765", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525765", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QVEGQGY", "url": "https://omabrowser.org/oma/group/QVEGQGY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAC0", "url": "https://www.orthodb.org/?gene=E1BAC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47362", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47362", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47362:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47362:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-77289", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77289", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179546", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SM20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAC0", "url": "https://www.uniprot.org/uniprotkb/E1BAC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRRGFQAAVILGHHGTLPGATHLLPRFNPASAFGSSMESLVSRFCQEMKKSKNYALPNASWGPDMLSLYHEFLEKTKTSGWVRVPSFRSNRDHIQGFKLPLDLSANSDKSDWRLFTRCIEREGQGYEYVIFFQPSEKKSICLFQPGPYLEGVPGFVHGGSLAALIDETFSKTAYLSGEGLLTVNFNIRFKNLIPLGSLAVLNVNVEKIEDQKMYLSCVTQSRDQQTVYAKASGTFLQMHLEEDSSRQ", "length": 248, "header": "tr|A0AAA9SM20-1|A0AAA9SM20_BOVIN Isoform 1 of Thioesterase superfamily member 5 OS=Bos taurus OX=9913 GN=THEM5 PE=4 SV=1 CANONICAL=A0AAA9SM20-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20/entry#A0AAA9SM20-1", "sequence": { "sequence": "MLRRGFQAAVILGHHGTLPGATHLLPRFNPASAFGSSMESLVSRFCQEMKKSKNYALPNASWGPDMLSLYHEFLEKTKTSGWVRVPSFRSNRDHIQGFKLPLDLSANSDKSDWRLFTRCIEREGQGYEYVIFFQPSEKKSICLFQPGPYLEGVPGFVHGGSLAALIDETFSKTAYLSGEGLLTVNFNIRFKNLIPLGSLAVLNVNVEKIEDQKMYLSCVTQSRDQQTVYAKASGTFLQMHLEEDSSRQ", "length": 248, "header": "tr|A0AAA9SM20-1|A0AAA9SM20_BOVIN Isoform 1 of Thioesterase superfamily member 5 OS=Bos taurus OX=9913 GN=THEM5 PE=4 SV=1 CANONICAL=A0AAA9SM20-1" }, "locus": { "chromosome": "3", "start_pos": 18932044, "end_pos": 18922266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108060.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108060.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087397.1" } ] } }, { "isoform_ac": "E1BAC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20/entry#E1BAC0-1", "sequence": { "sequence": "MELFLVPPTSCPDSTLPQPSDPPWSPWWTLCHLSHHGDQPKSPLPRSWPGQVSRFCQEMKKSKNYALPNASWGPDMLSLYHEFLEKTKTSGWVRVPSFRSNRDHIQGFKLPLDLSANSDKSDWRLFTRCIEREGQGYEYVIFFQPSEKKSICLFQPGPYLEGVPGFVHGGSLAALIDETFSKTAYLSGEGLLTVNFNIRFKNLIPLGSLAVLNVNVEKIEDQKMYLSCVTQSRDQQTVYAKASGTFLQMHLEEDSSRQ", "length": 258, "header": "tr|E1BAC0-1|E1BAC0_BOVIN Computationally mapped isoform of Thioesterase superfamily member 5 OS=Bos taurus OX=9913 GN=THEM5 PE=4 SV=2 CANONICAL=A0AAA9SM20-1" }, "locus": { "chromosome": "3", "start_pos": 18932044, "end_pos": 18922309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000922.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000922.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000922.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000922.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525765", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525765", "resource": "KEGG Pathway" }, { "id": "R-BTA-77289", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77289", "resource": "Reactome", "description": "Mitochondrial Fatty Acid Beta-Oxidation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AEW3-1", "protein_name": "Thioesterase superfamily member 5", "gene_name": "Them5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMRTGFQGVARLVHHKALYRSPQTLPRLHLASAFGSSTDSLVARFCGEKTDLKDYALPNASWCPDMLSLYQEFLEKTKSGSWVKLPSFKSNRDHIRGLKLPFGLVAASDKQDWRLFTRSIQLEGQGYEYVIFFHPSEKKSVCLFQPGPYLEGAPGFAHGGSLAALMDETYSKTAYLAGEGLFTLSFNIKFKNLIPVGSLAVLDLQVEKIEDQKLYMSCIAQSRDKQTVYAKSSGKEICSLSLGCLPLPNPQQGGKQRVKDQVLSWSLVLLGVGMLLARDMDEEKEKKTRIFLVRITQPAPLQDSLG", "length": 306 }, "evidence": [ { "id": "A0AAA9SM20", "url": "https://omabrowser.org/oma/group/A0AAA9SM20/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1ST19-1", "protein_name": "Thioesterase superfamily member 5", "gene_name": "THEM5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIRKGFQMAARLGHHRAHPGALNSLSRFNSASVFGSSMDSVVSRTCQEKTDLKNYASPNASWCPDMLSLYHDFLEKTKADGWVKLLSFKSNRDHIQGFKMPSGLQVTSDKRDWRLFTRCIETEGQGYEYVIFFHPSQKKSVCLFQPGPYLEGPPGFAHGGSLAAMIDETFSKTAYLAGEGLLTLNLNISFKNLIPVDSLAVLNVDVEKIENQKIYMSCIIQSRDQQTLYAKASGIFLQMSLEKDSSK", "length": 247 }, "evidence": [ { "id": "A0AAA9SM20", "url": "https://omabrowser.org/oma/group/A0AAA9SM20/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8N1Q8-1", "protein_name": "Acyl-coenzyme A thioesterase THEM5", "gene_name": "THEM5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSRFLPEKTDLKDYALPNASWCSDMLSLYQEFLEKTKSSGWIKLPSFKSNRDHIRGLKLPSGLAVSSDKGDCRIFTRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYLEGPPGFAHGGSLAAMMDETFSKTAFLAGEGLFTLSLNIRFKNLIPVDSLVVMDVELDKIEDQKLYMSCIAHSRDQQTVYAKSSGVFLQLQLEEESPQ", "length": 247 }, "evidence": [ { "id": "A0AAA9SM20", "url": "https://omabrowser.org/oma/group/A0AAA9SM20/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQJ0-1", "protein_name": "Acyl-coenzyme A thioesterase THEM5", "gene_name": "Them5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRTSFQGVARLVRHKALYRSPCLLPRVHLASAFGSSTESLVARFCPEKTDLKDYALPNASWCSDMLSLYQEFLEKTKSGGWIKLPSFKSNRDHIQGLKLPFGLETASDKQDWRLFTRSIQLEGQGYEYVIFFHPSEKKSVCLFQPGPYLEGAPGFAHGGSLAALMDETYSKTAYLAGEGLFTLSLNIKFKNLIPVGSLAVLDIQVEKIEDQKLYMSCIAQSRDKQTVYAKSSGVFLQLQLEEQSQEQ", "length": 248 }, "evidence": [ { "id": "A0AAA9SM20", "url": "https://omabrowser.org/oma/group/A0AAA9SM20/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "long-chain fatty-acyl-CoA metabolic process", "id": "GO:0035336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "long-chain fatty acyl-CoA hydrolase activity", "id": "GO:0052816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052816", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SM20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM20" }, { "id": "PF03061", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioesterase", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 225, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM42-1", "uniprot_ac": "A0AAA9SM42", "uniprot_id": "A0AAA9SM42_BOVIN", "mass": { "chemical_mass": 21958.0, "monoisotopic_mass": 21958.0 }, "refseq": { "ac": "XP_010814588", "name": "keratin-associated protein 4-7-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814588" }, "gene_names": [ { "name": "LOC100848572", "type": "recommended", "evidence": [ { "id": "A0AAA9SM42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42" } ] }, { "name": "LOC100848572", "type": "synonym", "evidence": [ { "id": "XP_010814588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814588" } ] } ], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SM42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42/entry#names_and_taxonomy" } ] }, { "name": "keratin-associated protein 4-7-like", "type": "synonym", "evidence": [ { "id": "XP_010814588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814588" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42#function" }, { "database": "UniProtKB", "id": "ARBA00003327", "url": "https://www.uniprot.org/uniprotkb/ARBA00003327#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100848572", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42", "locus": {} } ], "crossref": [ { "id": "A0AAA9SM42", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM42", "database": "AlphaFoldDB", "categories": [] }, { "id": "100848572", "url": "https://www.ncbi.nlm.nih.gov/gene/100848572", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848572", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848572", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCSETCC", "url": "https://omabrowser.org/oma/group/CCSETCC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262:SF183", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262:SF183", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01500", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01500", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010814588", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814588", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SM42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSSCCGSVCSDQSCGRSLCLETCCRPTCCRTTCCRTTCCRPSCGVSSCCRPVCCQPTCPRPTCCISSCYRPSCCVSSCGSSSCRPTCCISSCCRPQCCQPVCCQPTCPRPTCCISSCCRPSCCGSSCGSNCCRPACCISSCCRPRCCQSVCCQPTCSRISSCCRPSCCGSSCCLRPVCGRVSCHTTCYRPTCVISTCPRPVCCPSSCC", "length": 209, "header": "tr|A0AAA9SM42-1|A0AAA9SM42_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC100848572 PE=4 SV=1 CANONICAL=A0AAA9SM42-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42/entry#A0AAA9SM42-1", "sequence": { "sequence": "MVSSCCGSVCSDQSCGRSLCLETCCRPTCCRTTCCRTTCCRPSCGVSSCCRPVCCQPTCPRPTCCISSCYRPSCCVSSCGSSSCRPTCCISSCCRPQCCQPVCCQPTCPRPTCCISSCCRPSCCGSSCGSNCCRPACCISSCCRPRCCQSVCCQPTCSRISSCCRPSCCGSSCCLRPVCGRVSCHTTCYRPTCVISTCPRPVCCPSSCC", "length": 209, "header": "tr|A0AAA9SM42-1|A0AAA9SM42_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC100848572 PE=4 SV=1 CANONICAL=A0AAA9SM42-1" }, "locus": { "chromosome": "19", "start_pos": 41301553, "end_pos": 41300927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110771.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110771.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083816.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083816.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848572", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848572", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9BYR0-1", "protein_name": "Keratin-associated protein 4-7", "gene_name": "KRTAP4-7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVSSCCGSVCSDQGCSQDLCQETCCRPSCCQTTCCRTTCYRPSCCVSSCCRPQCCQSVCCQPTCCRPTCCETTCCHPRCCISSCCRPSCCMSSCCKPQCCQSVCCQPTCCRPSCCRPCCCLRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC", "length": 155 }, "evidence": [ { "id": "A0AAA9SM42", "url": "https://omabrowser.org/oma/group/A0AAA9SM42/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM64-1", "uniprot_ac": "A0AAA9SM64", "uniprot_id": "A0AAA9SM64_BOVIN", "mass": { "chemical_mass": 65717.0, "monoisotopic_mass": 65717.0 }, "refseq": { "ac": "XP_024834733", "name": "zinc finger protein 319 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834733" }, "gene_names": [ { "name": "ZNF319", "type": "recommended", "evidence": [ { "id": "A0AAA9SM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ] }, { "name": "ZNF319", "type": "synonym", "evidence": [ { "id": "XP_024834733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834733" } ] } ], "protein_names": [ { "name": "Zinc finger protein 319", "type": "synonym", "evidence": [ { "id": "A0AAA9SM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 319 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024834733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834733" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW3#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64#function" }, { "database": "UniProtKB", "id": "G3N1Z7", "url": "https://www.uniprot.org/uniprotkb/G3N1Z7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF319", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64", "locus": { "chromosome": "18", "start_pos": 25894468, "end_pos": 25907712, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045572", "url": "https://www.ensembl.org/id/ENSBTAG00000045572" } ] } } ], "crossref": [ { "id": "A0AAA9SM64", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM64", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045572", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045572", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618783", "url": "https://www.ncbi.nlm.nih.gov/gene/618783", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618783", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618783", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QHHSAHT", "url": "https://omabrowser.org/oma/group/QHHSAHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N1Z7", "url": "https://www.orthodb.org/?gene=G3N1Z7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834733", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834733", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1Z7", "url": "https://www.uniprot.org/uniprotkb/G3N1Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1Z7-1", "url": "https://www.uniprot.org/uniprotkb/G3N1Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPEPGLQPPQHVPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSAHSGTGGLVKCSICEKTYKPAEAAEPEATAAPSLPPAPPPPPAVAPAESADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKAEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCHKAYKRASALQKHQLAHCSAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCDKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQDSLS", "length": 584, "header": "tr|A0AAA9SM64-1|A0AAA9SM64_BOVIN Isoform 1 of Zinc finger protein 319 OS=Bos taurus OX=9913 GN=ZNF319 PE=3 SV=1 CANONICAL=A0AAA9SM64-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64/entry#A0AAA9SM64-1", "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPEPGLQPPQHVPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSAHSGTGGLVKCSICEKTYKPAEAAEPEATAAPSLPPAPPPPPAVAPAESADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKAEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCHKAYKRASALQKHQLAHCSAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCDKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQDSLS", "length": 584, "header": "tr|A0AAA9SM64-1|A0AAA9SM64_BOVIN Isoform 1 of Zinc finger protein 319 OS=Bos taurus OX=9913 GN=ZNF319 PE=3 SV=1 CANONICAL=A0AAA9SM64-1" }, "locus": { "chromosome": "18", "start_pos": 25904558, "end_pos": 25902580, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102594.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102594.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086376.1" } ] } }, { "isoform_ac": "A0AAA9SNW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64/entry#A0AAA9SNW3-1", "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPEPGLQPPQHVPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSAHSGTGGLVKCSICEKTYKPAEAAEPEATAAPSLPPAPPPPPAVAPAESADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKAEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCHKAYKRASALQKHQLAHCSAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCDKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP", "length": 586, "header": "tr|A0AAA9SNW3-1|A0AAA9SNW3_BOVIN Computationally mapped isoform of Zinc finger protein 319 OS=Bos taurus OX=9913 GN=ZNF319 PE=3 SV=1 CANONICAL=A0AAA9SM64-1" }, "locus": { "chromosome": "18", "start_pos": 25904558, "end_pos": 25902801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131030.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131030.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079504.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079504.1" } ] } }, { "isoform_ac": "G3N1Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64/entry#G3N1Z7-1", "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPEPGLQPPQHVPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSAHSGTGGLVKCSICEKTYKPAEAAEPEATAAPSLPPAPPPPPAVAPAESADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKAEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCHKAYKRASALQKHQLAHCSAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCDKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVNPHPATPHLCLLS", "length": 594, "header": "tr|G3N1Z7-1|G3N1Z7_BOVIN Computationally mapped isoform of Zinc finger protein 319 OS=Bos taurus OX=9913 GN=ZNF319 PE=3 SV=3 CANONICAL=A0AAA9SM64-1" }, "locus": { "chromosome": "18", "start_pos": 25904558, "end_pos": 25894507, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063509.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063509.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055902.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055902.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618783", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618783", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZY36-1", "protein_name": "Zinc finger protein 319", "gene_name": "ZNF319", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPDPGLQPPQHAPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSAHSGTGGLVKCSICEKTYKPAEAAEPAAAAAPSLPPAAPPPAVAPAEQTDKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCNKAYKRASALQKHQLAHCSAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP", "length": 585 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M2BLK1-1", "protein_name": "Zinc finger protein 319", "gene_name": "znf319b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTEAWQQHAVAPPPVVHTIPPGADALGCTVYGIVLQPDTTLQQQQQQQQQQQQHHSQQHNQQQQHPAQSQQPSLHVGNEGGHKCGACGHDISHLANPHEHQCMVSQDRSFQCTQCLKIFHQATDLLEHQCVQVEQKPFVCGVCKMGFSLLTSLAQHHNAHNSGNPMKCSICEKTYRPGSGNATPTSSSATPGQPSNDEASSSGSAAVGTSGQPTFEPSHPDRPYKCSVCTKGFRHLSELTRHERVHTGEKPFKCETCDKSFSQSSHLAHHQRTHSSERPFKCAVCEKSFKHRSHLVRHMYAHSGEHLFKCNLCELHFKESSELLHHQCQPQGARPFRCATCGKGFKRPSDLRQHERTHSEERPFHCEDCQMSFKQQYALVRHRRTHKPSADRPFKCNLCDKGFLQPSHLLYHQHVHGMDNLFKCASCGKGFSQSGELLRHKCGESSSTPTNPDKPYKCDVCGKAYKKATTLQRHQNSHCTEKPLKCSLCDRRFLSSSEFVQHRCDPSREKPLKCPDCEKRFKYSSEMQRHRRVHTGEKPYKCASCDKGFKQREHLAKHQSVHARDAQFKCVWCGERFADLGALQEHTVQHTAEGGGYPVSSLIQ", "length": 604 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D4AEC6-1", "protein_name": "Zinc finger protein 319", "gene_name": "Zfp319", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSESWQQPPQTQPQQPQAPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPDPGLQPPQHAPLQAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSSHTGMVKCSICDKTYKPAEAAEPATTTAPSLPSAPPPTNVAPVEQPEKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGSTERPFKCPVCNKAYKRASALQKHQLSHCAAAEKPLRCTLCERRFFSSSEFVQHRCDPTREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP", "length": 581 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1P3T2-1", "protein_name": "Zinc finger protein 319", "gene_name": "ZNF319", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSESWQQQQQQPQQPPPPPQQHHAGTTALPEHSIPPSSADNPLGCAVYGILLQPDPGLQHHQHAPLQAGEPSHKCGVCGHDLTHLSNPHEHQCLPGHDRSFQCTQCLKIFHQATDLLEHQCIQVEQKPFVCGVCKMGFSLLTSLAQHHNVHNGNAMKCSICEKTYKPPEAEHPQPLDPSEKPYSCSICQKTFKHLSELSRHERVHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCTVCEKTFKHRSHLVRHMYAHSGEHLFKCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSEERPFKCDLCQMSFKQQYALMRHRRTHKAEEPFKCNLCEKGFVQPSHLVYHQHVHGIENLFKCNVCQKGFNQSSELLRHKCVQNAERPFKCAVCNKSYKRASALQKHQLAHCAEKPLKCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPSCEKAFKQREHLNKHHSVHAREQQYKCMWCGERFLDLGLLQEHSVQHTAEGAYQVAACLP", "length": 554 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I3J7-1", "protein_name": "Zinc finger protein 319", "gene_name": "Znf319", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPDPGLQPPQHAPLQAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHTSHTGMVKCSICDKTYKPTEAAEPATTTAPSVPPAPPPTSVAPAEQPEKPYSCTICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCNECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPSSTERPFKCPVCNKAYKRASALQKHQLSHCAAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP", "length": 581 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9ERR8-1", "protein_name": "Zinc finger protein 319", "gene_name": "Znf319", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSESWQQPPQTQPQQPQAPQPQHHAETPPALAEHTLPPGSAENPLGCAVYGILLQPDPGLQPPQHAPLQAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSSHTGMVKCSICDKTYKPAEAAEPATTTAPSLPSAPPPANIAPVEQPEKPYSCPVCQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPTSTERPFKCPVCNKAYKRASALQKHQLSHCAAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPSCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP", "length": 581 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2F9-1", "protein_name": "Zinc finger protein 319", "gene_name": "ZNF319", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSESWQQPPQTQPQQPQPPQPQHHAEPPPALAEHTLPPGTAENPLGCAVYGILLQPDPGLQPPQHAPLQAAGEPGPKCGVCGHDLAHLSSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGVCKMGFSLLTSLAQHHSSHSGLVKCSICEKTYKPAEAAEPATTAAPSLPAAPAPSTVTPAEQADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAVCEKTFKHRSHLVRHMYAHSGEHHLFRCNVCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEKGFGQPSHLLYHQHVHTLETLFKCPVCQKGFDQSAELLRHKCLPGAAERPFKCPVCNKAYKRASALQKHQLAHCAAAEKPLRCTLCERRFFSSSEFVQHRCDPAREKPLKCPDCEKRFKYASDLQRHRRVHTGEKPYKCPNCDKAFKQREHLNKHQGVHAREQQFKCVWCGERFLDVALLQEHSAQHSAAAAAAEGAYQVAACLP", "length": 582 }, "evidence": [ { "id": "A0AAA9SM64", "url": "https://omabrowser.org/oma/group/A0AAA9SM64/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SM64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM64" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 131, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM65-1", "uniprot_ac": "A0AAA9SM65", "uniprot_id": "A0AAA9SM65_BOVIN", "mass": { "chemical_mass": 10887.0, "monoisotopic_mass": 10887.0 }, "refseq": {}, "gene_names": [ { "name": "CCL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SM65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65" } ] } ], "protein_names": [ { "name": "C-C motif chemokine 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SM65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65/entry#names_and_taxonomy" } ] }, { "name": "Small-inducible cytokine A1", "type": "synonym", "evidence": [ { "id": "A0AAA9SM65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65", "locus": { "chromosome": "19", "start_pos": 15786778, "end_pos": 15783012, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008832", "url": "https://www.ensembl.org/id/ENSBTAG00000008832" } ] } } ], "crossref": [ { "id": "A0AAA9SM65", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM65", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786156", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786156", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SSNCCFT", "url": "https://omabrowser.org/oma/group/SSNCCFT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SM65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLIIAALVCLLLAGMWLQDVDAKSMHVPSSNCCFRTVKGKISPKKIQCYKNISSTCSYNDRLIFKLTGGLQSCVLQKDLWVQAYLKRINLCQKEM", "length": 96, "header": "tr|A0AAA9SM65-1|A0AAA9SM65_BOVIN Isoform 1 of C-C motif chemokine 1 OS=Bos taurus OX=9913 GN=CCL1 PE=3 SV=2 CANONICAL=A0AAA9SM65-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65/entry#A0AAA9SM65-1", "sequence": { "sequence": "MKLIIAALVCLLLAGMWLQDVDAKSMHVPSSNCCFRTVKGKISPKKIQCYKNISSTCSYNDRLIFKLTGGLQSCVLQKDLWVQAYLKRINLCQKEM", "length": 96, "header": "tr|A0AAA9SM65-1|A0AAA9SM65_BOVIN Isoform 1 of C-C motif chemokine 1 OS=Bos taurus OX=9913 GN=CCL1 PE=3 SV=2 CANONICAL=A0AAA9SM65-1" }, "locus": { "chromosome": "19", "start_pos": 15786208, "end_pos": 15783417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117108.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117108.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087450.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087450.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786156", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786156", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDY4-1", "protein_name": "C-C motif chemokine", "gene_name": "Ccl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLLNMVLVCLLVAAMWLQNVDSKSMHVVSSRCCLNTLENKIALKFIKCYKEIGPSCPYYPAVIFRLIKGRESCALTNTTWVQDYLKKVKPC", "length": 92 }, "evidence": [ { "id": "A0AAA9SM65", "url": "https://omabrowser.org/oma/group/A0AAA9SM65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P10146-1", "protein_name": "C-C motif chemokine 1", "gene_name": "Ccl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPTAMALMCLLLAAVWIQDVDSKSMLTVSNSCCLNTLKKELPLKFIQCYRKMGSSCPDPPAVVFRLNKGRESCASTNKTWVQNHLKKVNPC", "length": 92 }, "evidence": [ { "id": "A0AAA9SM65", "url": "https://omabrowser.org/oma/group/A0AAA9SM65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P22362-1", "protein_name": "C-C motif chemokine 1", "gene_name": "CCL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQIITTALVCLLLAGMWPEDVDSKSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNEGLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK", "length": 96 }, "evidence": [ { "id": "A0AAA9SM65", "url": "https://omabrowser.org/oma/group/A0AAA9SM65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SM65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM65" }, { "id": "SM00199", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chemokine interleukin-8-like", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 89, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SM96-1", "uniprot_ac": "A0AAA9SM96", "uniprot_id": "A0AAA9SM96_BOVIN", "mass": { "chemical_mass": 21334.0, "monoisotopic_mass": 21334.0 }, "refseq": {}, "gene_names": [ { "name": "C23H6orf136", "type": "recommended", "evidence": [ { "id": "A0AAA9SM96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96" } ] } ], "protein_names": [ { "name": "Chromosome 23 C6orf136 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SM96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SM96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C23H6orf136", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96", "locus": { "chromosome": "23", "start_pos": 28349054, "end_pos": 28353973, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006958", "url": "https://www.ensembl.org/id/ENSBTAG00000006958" } ] } } ], "crossref": [ { "id": "A0AAA9SM96", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SM96", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006958", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006958", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR018790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MVB5", "url": "https://www.orthodb.org/?gene=F1MVB5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31094", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31094", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31094:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31094:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10184", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10184", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SM96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U016", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U016", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U016-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U016-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVB5", "url": "https://www.uniprot.org/uniprotkb/F1MVB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVB5-1", "url": "https://www.uniprot.org/uniprotkb/F1MVB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYQPSRGAARRLGPCLRAYQARPQLPNLFLHSHDYTLYSSDVEFINEILNMRTKGRTWYILSLTLCRFLAWNYFAQLRLEILQLTRHPENWTLQARWRLVGLPIHLLFLRFYKRDKEELYRTYDAYSTFYLNSNGLICRHRLDKLMPSHSPPAPVKKLLVGALVALGLSEPEPNLHLCSKD", "length": 181, "header": "tr|A0AAA9SM96-1|A0AAA9SM96_BOVIN Isoform 1 of Chromosome 23 C6orf136 homolog OS=Bos taurus OX=9913 GN=C23H6orf136 PE=4 SV=1 CANONICAL=A0AAA9SM96-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96/entry#A0AAA9SM96-1", "sequence": { "sequence": "MYQPSRGAARRLGPCLRAYQARPQLPNLFLHSHDYTLYSSDVEFINEILNMRTKGRTWYILSLTLCRFLAWNYFAQLRLEILQLTRHPENWTLQARWRLVGLPIHLLFLRFYKRDKEELYRTYDAYSTFYLNSNGLICRHRLDKLMPSHSPPAPVKKLLVGALVALGLSEPEPNLHLCSKD", "length": 181, "header": "tr|A0AAA9SM96-1|A0AAA9SM96_BOVIN Isoform 1 of Chromosome 23 C6orf136 homolog OS=Bos taurus OX=9913 GN=C23H6orf136 PE=4 SV=1 CANONICAL=A0AAA9SM96-1" }, "locus": { "chromosome": "23", "start_pos": 28352672, "end_pos": 28349239, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119108.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119108.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086411.1" } ] } }, { "isoform_ac": "A0AAA9U016-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96/entry#A0AAA9U016-1", "sequence": { "sequence": "MYSFIHLFILQAFFFFKSVPSHLYLIFNQSNKVFFTTSVTENCGCRYFSPTPHPSAPTFAQAYRSRLRGALTPVRRPEAGHRRRSLRSRKIMYQPSRGAARRLGPCLRAYQARPQDQSSPWALPFPPLWPHSTTTTSPSLPLFWSPPPPSPPTRLLPPAPPLPLPQVQALTSPWVVLPPGKGEEGPGPELLSGCLDGLRSLFEGPPCPCPGALIPFQAPGTAHPSPATPSGDPSMEEHLAVMYERLRQELPNLFLHSHDYTLYSSDVEFINEILNMRTKGRTWYILSLTLCRFLAWNYFAQLRLEILQLTRHPENWTLQARWRLVGLPIHLLFLRFYKRDKEELYRTYDAYSTFYLNSNGLICRHRLDKLMPSHSPPAPVKKLLVGALVALGLSEPEPNLHLCSKD", "length": 406, "header": "tr|A0AAA9U016-1|A0AAA9U016_BOVIN Computationally mapped isoform of Chromosome 23 C6orf136 homolog OS=Bos taurus OX=9913 GN=C23H6orf136 PE=4 SV=1 CANONICAL=A0AAA9SM96-1" }, "locus": { "chromosome": "23", "start_pos": 28353148, "end_pos": 28349239, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102906.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102906.1" } ] } }, { "isoform_ac": "F1MVB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM96/entry#F1MVB5-1", "sequence": { "sequence": "MSQYRSRLRGALTPVRRPEAGHRRRSLRSRKIMYQPSRGAARRLGPCLRAYQARPQDQSSPWALPFPPLWPHSTTTTSPSLPLFWSPPPPSPPTRLLPPAPPLPLPQVQALTSPWVVLPPGKGEEGPGPELLSGCLDGLRSLFEGPPCPCPGALIPFQAPGTAHPSPATPSGDPSMEEHLAVMYERLRQELPNLFLHSHDYTLYSSDVEFINEILNMRTKGRTWYILSLTLCRFLAWNYFAQLRLEILQLTRHPENWTLQARWRLVGLPIHLLFLRFYKRDKEELYRTYDAYSTFYLNSNGLICRHRLDKLMPSHSPPAPVKKLLVGALVALGLSEPEPNLHLCSKD", "length": 347, "header": "tr|F1MVB5-1|A0AAA9SM96_BOVIN Computationally mapped isoform of Chromosome 23 C6orf136 homolog OS=Bos taurus OX=9913 GN=C23H6orf136 PE=4 SV=2 CANONICAL=A0AAA9SM96-1" }, "locus": { "chromosome": "23", "start_pos": 28353907, "end_pos": 28349239, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035893.4", "url": "https://www.ensembl.org/id/ENSBTAT00000035893.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035760.3", "url": "https://www.ensembl.org/id/ENSBTAP00000035760.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMB0-1", "uniprot_ac": "A0AAA9SMB0", "uniprot_id": "A0AAA9SMB0_BOVIN", "mass": { "chemical_mass": 35106.0, "monoisotopic_mass": 35106.0 }, "refseq": {}, "gene_names": [ { "name": "OR7A89", "type": "recommended", "evidence": [ { "id": "A0AAA9SMB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0" } ] } ], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SMB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7A89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SMB0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEARNKTRISEFLLLGFSEEPEIQPLIFGLFLSMYLITVFGNLLIILAVSSDSHFHTPMYFFLSNLSFVDICFTSTTIPKMLWNIQAQNKAITYEGCIIQMYFFILFVCLDDFLLTVMAYDRFVAICHPLHYTVMMNSQLCGLLMLVSWVMSALNSLIQSLMVLQLSFCTDLEIPHFFCEINQMVRLACSDTFFNDMLFYFAAGMFGFLTLTGILYSYSKIVSSIRGISSAQGKYKAFSTCASHLSMVCLFYCTSLGVYLSSAATQSSHSSATASVMYTVITPMLNPFIYSLRNKDIKRALERILEMAAT", "length": 310, "header": "tr|A0AAA9SMB0-1|A0AAA9SMB0_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=OR7A89 PE=3 SV=1 CANONICAL=A0AAA9SMB0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0/entry#A0AAA9SMB0-1", "sequence": { "sequence": "MEARNKTRISEFLLLGFSEEPEIQPLIFGLFLSMYLITVFGNLLIILAVSSDSHFHTPMYFFLSNLSFVDICFTSTTIPKMLWNIQAQNKAITYEGCIIQMYFFILFVCLDDFLLTVMAYDRFVAICHPLHYTVMMNSQLCGLLMLVSWVMSALNSLIQSLMVLQLSFCTDLEIPHFFCEINQMVRLACSDTFFNDMLFYFAAGMFGFLTLTGILYSYSKIVSSIRGISSAQGKYKAFSTCASHLSMVCLFYCTSLGVYLSSAATQSSHSSATASVMYTVITPMLNPFIYSLRNKDIKRALERILEMAAT", "length": 310, "header": "tr|A0AAA9SMB0-1|A0AAA9SMB0_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=OR7A89 PE=3 SV=1 CANONICAL=A0AAA9SMB0-1" }, "locus": { "chromosome": "7", "start_pos": 9441226, "end_pos": 9440297, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105222.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105222.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085029.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085029.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMB4-1", "uniprot_ac": "A0AAA9SMB4", "uniprot_id": "A0AAA9SMB4_BOVIN", "mass": { "chemical_mass": 136120.0, "monoisotopic_mass": 136120.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100847574", "type": "recommended", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] } ], "protein_names": [ { "name": "Multidrug resistance-associated protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.3", "type": "synonym", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules. Confers resistance to anticancer agents such as methotrexate.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4#function" }, { "database": "UniProtKB", "id": "ARBA00094206", "url": "https://www.uniprot.org/uniprotkb/ARBA00094206#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100847574", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SMB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "66424", "url": "https://www.rhea-db.org/rhea/66424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISYVENYDPTDSAALHEAYGYAAGLSACVLVWAVLHHLCFYHMQRVGMRLRVAVCHMIYHKALRLSSPAMGKTTTGQIVNLLSNDVNRFDQVIVFLHYLWVGPLQAVAVTALLWMEIGISCLAGMAVLIILLLLQSCFGKLFSSLRSKTAALTDKRIRTMSEVITGIRTIKMNAWEKSFIDLITRLRSKEISKILKSSYLRGMNLTSFFTVSKIMIFVTFITNELLDNWITASQVFVVVTLFEALRFSSTLYFPMAIKKVSEAVVSLRRIKNFLSLDEIPQLNTQLPSDGEMIVDMQDFTAFWDEELELPTLKGLSFTVRPGELLTVVGPVGAGKSSLLRALLGELAPSQGKVSVHGRIAYVSQQPWLFPGTVRSNILFGKKYEEERYKEVIKACALEEDLQNLKERDLTVTGDGGTPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDARVSRHLFELCVHQALKEKITILVTHQLQYLKDASQILILKDDKTVERGTYSEFLKSGVDIFSLFEKRNKQPGSSPVLGTPTLISESLVRSPSSPRPSLKDAVPEDQDTENIQVTLPLEDYLEGKVGFKTYKNYFTAGAGWPLITFLILVNIAAQVAYVLQDWWLALWANLQINLYSGALVKEDADVMLLLNWCLRVYSGLTVSTVLFGITRSLLIFYIFVNSSQTLHNKILESILRAPVSFFNSNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVIGVMVAVIPWIAIPVIPLGIAFFFLQRYFSETSRDIKHLECATRSPVFSHLASSLRGVWTIRTYKAEQSFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVICAIFVTVVAFVSLILADALTLGQVGLVLSLALTLMGMFQWCIRQRTEVENLMISVERVTGYLDLEKEAPWEYKDRAPPPWTNEGRILFHTVNFRHTLDGPLVLKNLTAVIESTKKVGIVGRTGAGKSSVFSAVFRLSEPEGYLWVDRCLIGRAGLHNLRKKMSIILQEPVLFTGTMRKNLDPFNEHTDKELWNALEEVQLKETIEGLPGKMDTALAETGANLSVGQRQLVCLARVILKKNQILIIDKATSNVDARTDELIKKAIHEKFAQCTVVTITHRLSTIIDSDMIMVLDSGTVKEYSPPHDLLQNSKSLFYKMVQQLGEAEATALTERAKQVSLLQGVRRQWRPNSSTLAWKISWTEEPGRLQSMGSLSWT", "length": 1211, "header": "tr|A0AAA9SMB4-1|A0AAA9SMB4_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC100847574 PE=3 SV=2 CANONICAL=A0AAA9SMB4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4/entry#A0AAA9SMB4-1", "sequence": { "sequence": "MISYVENYDPTDSAALHEAYGYAAGLSACVLVWAVLHHLCFYHMQRVGMRLRVAVCHMIYHKALRLSSPAMGKTTTGQIVNLLSNDVNRFDQVIVFLHYLWVGPLQAVAVTALLWMEIGISCLAGMAVLIILLLLQSCFGKLFSSLRSKTAALTDKRIRTMSEVITGIRTIKMNAWEKSFIDLITRLRSKEISKILKSSYLRGMNLTSFFTVSKIMIFVTFITNELLDNWITASQVFVVVTLFEALRFSSTLYFPMAIKKVSEAVVSLRRIKNFLSLDEIPQLNTQLPSDGEMIVDMQDFTAFWDEELELPTLKGLSFTVRPGELLTVVGPVGAGKSSLLRALLGELAPSQGKVSVHGRIAYVSQQPWLFPGTVRSNILFGKKYEEERYKEVIKACALEEDLQNLKERDLTVTGDGGTPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDARVSRHLFELCVHQALKEKITILVTHQLQYLKDASQILILKDDKTVERGTYSEFLKSGVDIFSLFEKRNKQPGSSPVLGTPTLISESLVRSPSSPRPSLKDAVPEDQDTENIQVTLPLEDYLEGKVGFKTYKNYFTAGAGWPLITFLILVNIAAQVAYVLQDWWLALWANLQINLYSGALVKEDADVMLLLNWCLRVYSGLTVSTVLFGITRSLLIFYIFVNSSQTLHNKILESILRAPVSFFNSNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVIGVMVAVIPWIAIPVIPLGIAFFFLQRYFSETSRDIKHLECATRSPVFSHLASSLRGVWTIRTYKAEQSFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVICAIFVTVVAFVSLILADALTLGQVGLVLSLALTLMGMFQWCIRQRTEVENLMISVERVTGYLDLEKEAPWEYKDRAPPPWTNEGRILFHTVNFRHTLDGPLVLKNLTAVIESTKKVGIVGRTGAGKSSVFSAVFRLSEPEGYLWVDRCLIGRAGLHNLRKKMSIILQEPVLFTGTMRKNLDPFNEHTDKELWNALEEVQLKETIEGLPGKMDTALAETGANLSVGQRQLVCLARVILKKNQILIIDKATSNVDARTDELIKKAIHEKFAQCTVVTITHRLSTIIDSDMIMVLDSGTVKEYSPPHDLLQNSKSLFYKMVQQLGEAEATALTERAKQVSLLQGVRRQWRPNSSTLAWKISWTEEPGRLQSMGSLSWT", "length": 1211, "header": "tr|A0AAA9SMB4-1|A0AAA9SMB4_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC100847574 PE=3 SV=2 CANONICAL=A0AAA9SMB4-1" }, "locus": { "chromosome": "NKLS02001064.1", "start_pos": 386525, "end_pos": 163056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090494.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090494.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085078.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085078.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1057, "end_pos": 1059, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1185, "end_pos": 1187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 673, "end_pos": 675, "annotation": "n_glycosylation_sequon" }, { "start_pos": 941, "end_pos": 943, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "66424", "name": "", "equation": "leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RZT1-1", "A0AAA9T569-1", "A0AAA9SJG6-1", "A0AAA9TUR1-1", "A0AAA9S3M4-1", "G3MW08-1", "A0AAA9TZ11-1", "A0A3Q1LXZ2-1", "A0AAA9T4S3-1", "A0A3Q1LPI1-1", "A0AAA9TR50-1", "A0A3Q1ML89-1", "A0AAA9SMB4-1" ], "evidence": [ { "id": "66424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66424" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LPI1", "gene_name": "LOC107131247", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] } ] }, { "uniprot_ac": "A0A3Q1LXZ2", "gene_name": "LOC521568", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] } ] }, { "uniprot_ac": "A0A3Q1ML89", "gene_name": "LOC100299180", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] } ] }, { "uniprot_ac": "A0AAA9RZT1", "gene_name": "LOC100337390", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] } ] }, { "uniprot_ac": "A0AAA9S3M4", "gene_name": "LOC100848700", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] } ] }, { "uniprot_ac": "A0AAA9SJG6", "gene_name": "LOC101906567", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] } ] }, { "uniprot_ac": "A0AAA9SMB4", "gene_name": "LOC100847574", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] } ] }, { "uniprot_ac": "A0AAA9T4S3", "gene_name": "LOC520016", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] } ] }, { "uniprot_ac": "A0AAA9T569", "gene_name": "ABCC4", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] } ] }, { "uniprot_ac": "A0AAA9TR50", "gene_name": "LOC509854", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] } ] }, { "uniprot_ac": "A0AAA9TUR1", "gene_name": "LOC528412", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] } ] }, { "uniprot_ac": "A0AAA9TZ11", "gene_name": "", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] } ] }, { "uniprot_ac": "G3MW08", "gene_name": "LOC100337076", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" }, { "id": "PS50929", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50929" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transmembrane type-1", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 243, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 518, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.6.2.2", "ec_name": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "7.6.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2" }, { "id": "7.6.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.2" } ] }, { "ec_number": "7.6.2.3", "ec_name": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "7.6.2.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3" }, { "id": "7.6.2.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.3" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1057, "end_pos": 1059 }, { "start_pos": 1185, "end_pos": 1187 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 673, "end_pos": 675 }, { "start_pos": 941, "end_pos": 943 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMD9-1", "uniprot_ac": "A0AAA9SMD9", "uniprot_id": "A0AAA9SMD9_BOVIN", "mass": { "chemical_mass": 47036.0, "monoisotopic_mass": 47036.0 }, "refseq": { "ac": "XP_010799719", "name": "tripartite motif-containing protein 59 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799719" }, "gene_names": [ { "name": "TRIM59", "type": "recommended", "evidence": [ { "id": "A0AAA9SMD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ] }, { "name": "TRIM59", "type": "synonym", "evidence": [ { "id": "XP_010799719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799719" } ] } ], "protein_names": [ { "name": "Tripartite motif-containing protein 59", "type": "recommended", "evidence": [ { "id": "A0AAA9SMD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9/entry#names_and_taxonomy" } ] }, { "name": "tripartite motif-containing protein 59 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010799719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799719" } ] } ], "function": [ { "annotation": "E3 ubiquitin ligase involved in different processes such as development and immune response. Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT. Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9#function" }, { "database": "UniProtKB", "id": "ARBA00055104", "url": "https://www.uniprot.org/uniprotkb/ARBA00055104#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9", "locus": { "chromosome": "1", "start_pos": 107056539, "end_pos": 107028899, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058033", "url": "https://www.ensembl.org/id/ENSBTAG00000058033" } ] } } ], "crossref": [ { "id": "cd16763", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16763", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19790", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19790", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540154", "url": "https://www.ncbi.nlm.nih.gov/gene/540154", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24098:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24098:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010799719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHNFEDELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQATGNFYIWRPLRIPLKCPNCRSIIEIAPSGIESLPVNFALRAIIEKYQQEDHPDIITCPEHYRQPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYMKEKDTPQKLLEQLTDTHWTDLTCLIEKLEEQKSHSEKMVQGDKEVVLQYFKELSDTLEQKKKIFLTALCDVGNLINQEYTPQIERMKEIREQQLELVTLTTSLQEEAPLKFLEKVDDVRQRVHILKQRPLPNVQPVEIYPRVSQVLKEDWSRTEIGQIKKLLIPEMKISSKRIPCAWPDKEEKVEFFKILNIVIVTLISVILMLILFFNQHIITFLNEITSICFSEVSLSVYQSLSKNVHNLKNILCHTVYLLKEFMWKIISH", "length": 402, "header": "tr|A0AAA9SMD9-1|A0AAA9SMD9_BOVIN Isoform 1 of Tripartite motif-containing protein 59 OS=Bos taurus OX=9913 GN=TRIM59 PE=3 SV=1 CANONICAL=A0AAA9SMD9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9/entry#A0AAA9SMD9-1", "sequence": { "sequence": "MHNFEDELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQATGNFYIWRPLRIPLKCPNCRSIIEIAPSGIESLPVNFALRAIIEKYQQEDHPDIITCPEHYRQPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYMKEKDTPQKLLEQLTDTHWTDLTCLIEKLEEQKSHSEKMVQGDKEVVLQYFKELSDTLEQKKKIFLTALCDVGNLINQEYTPQIERMKEIREQQLELVTLTTSLQEEAPLKFLEKVDDVRQRVHILKQRPLPNVQPVEIYPRVSQVLKEDWSRTEIGQIKKLLIPEMKISSKRIPCAWPDKEEKVEFFKILNIVIVTLISVILMLILFFNQHIITFLNEITSICFSEVSLSVYQSLSKNVHNLKNILCHTVYLLKEFMWKIISH", "length": 402, "header": "tr|A0AAA9SMD9-1|A0AAA9SMD9_BOVIN Isoform 1 of Tripartite motif-containing protein 59 OS=Bos taurus OX=9913 GN=TRIM59 PE=3 SV=1 CANONICAL=A0AAA9SMD9-1" }, "locus": { "chromosome": "1", "start_pos": 107042496, "end_pos": 107041291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102276.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102276.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082633.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082633.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ], "pmid": "" }, { "name": "host-mediated suppression of symbiont invasion", "id": "GO:0046597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 92, "end_pos": 134, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD9" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 60, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SME3-1", "uniprot_ac": "A0AAA9SME3", "uniprot_id": "A0AAA9SME3_BOVIN", "mass": { "chemical_mass": 124781.0, "monoisotopic_mass": 124781.0 }, "refseq": {}, "gene_names": [ { "name": "C21H15orf39", "type": "recommended", "evidence": [ { "id": "A0AAA9SME3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3" } ] } ], "protein_names": [ { "name": "Chromosome 21 C15orf39 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SME3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C21H15orf39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3", "locus": { "chromosome": "21", "start_pos": 33542460, "end_pos": 33558870, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021021", "url": "https://www.ensembl.org/id/ENSBTAG00000021021" } ] } } ], "crossref": [ { "id": "A0AAA9SME3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SME3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR037656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCK2", "url": "https://www.orthodb.org/?gene=E1BCK2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28422", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28422", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28422:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28422:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SME3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCK2", "url": "https://www.uniprot.org/uniprotkb/E1BCK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCK2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRRAGGYRVCTAPAARFPEGWQRQALCTPGLRGAQAPRGAARLCPCCAGRSAPAPPPARPARDRRRRPAAARTAARRVAPGSVLTATSRAGPGRTRTRVLRGAGGCGRGAGQQQREAGCPAGQRLSSWGPGGLEAFTVMAEKRPLGTLGPVMYGKLPRLEADSGPGHSLPPSAGNQDSCSYKGAYFSCPMGAPPKTGSERLAPWTPYPPLYPTSMAGPPLRANNLLTSCLLYRPSTESSEKVQDSGPVELLPFGPQSHSYPGPPLAAPKPVYRSPLCYGLATCLGAGAPKKPLDVDWTLVTGSLLPPVGPSCSLPPASGKGQFLDGTFLRGVPAGASDKDSSVSFSPCQAFLEKYRALHGTGFLASKYASPYSGDPKQALSEGPPSPWTQLAQPLGPACQDAAPPHYPLPHPTQPVPCPPACRHPEKPGSYSSVLPLQPLGAPKGAGYPAGGLNSPYLRQQAIQTPYMPPVGLDPYAYPSAPLPAPSPGLKLEPPLTPRCPLDFAPQTLGFPYAREDLSLYGASPGLGGMPPSQNSVQALPKPGAFQRACQPLPASRPCSEPMRPAEKPVQEAEEKMWLPSCRKEHPQPQPQAQPQPQPPPRLDEHPGAPIVIGDSPVPRTPPPLPPCAQERQSLPQNEGSLPPSSPPMPVIDNVFSLAPYRDYLDVPAPEAPAEPELAPAPNESHDRDCGRSLPAQEAPSSEHPSLKEEVALDLSVKKTTAEASPTKVPHPMGRAKPTAAVDMPATGSNVSNVPGTGDTVSDPQGLQKAVTEVPEPPGLPVTTEATPRTNFHSSVAFMFRKFKIIRPAPLPATVVPSVPTLAPAPAQPVPTPTPVPPGLQMLTQPLPMACFGLTLPSPPAVAMASPASMPAPAPSPAPAPAPAPAPVAGPSPASTPTTADSSEQHFAGLHASLCDAISGSVAHSPPEKLREWLATSGPWGRAAWQDCQGVQGLLGKLLSQLQSFVCTQQCPFPHVVRAGAIFVPIHLVKERLFPRLPPASVDHVLQEHRVELRPTTLSEERALRERALHGCTSRMLKLLALRQLPDIYPDLLGLQWRDCVRRQLGDFNTEPGSVPSSESTMAREEPGSLDLTWKSAAPKAKKPGRKPPTPGPEKAEATAAGGSRGASPTPAAGASLPGPTVKARFRSLLESAWLNGLALPTWGHKASGPDRTAPRPQLLGSQSHQL", "length": 1189, "header": "tr|A0AAA9SME3-1|A0AAA9SME3_BOVIN Isoform 1 of Chromosome 21 C15orf39 homolog OS=Bos taurus OX=9913 GN=C21H15orf39 PE=4 SV=1 CANONICAL=A0AAA9SME3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SME3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3/entry#A0AAA9SME3-1", "sequence": { "sequence": "MASRRAGGYRVCTAPAARFPEGWQRQALCTPGLRGAQAPRGAARLCPCCAGRSAPAPPPARPARDRRRRPAAARTAARRVAPGSVLTATSRAGPGRTRTRVLRGAGGCGRGAGQQQREAGCPAGQRLSSWGPGGLEAFTVMAEKRPLGTLGPVMYGKLPRLEADSGPGHSLPPSAGNQDSCSYKGAYFSCPMGAPPKTGSERLAPWTPYPPLYPTSMAGPPLRANNLLTSCLLYRPSTESSEKVQDSGPVELLPFGPQSHSYPGPPLAAPKPVYRSPLCYGLATCLGAGAPKKPLDVDWTLVTGSLLPPVGPSCSLPPASGKGQFLDGTFLRGVPAGASDKDSSVSFSPCQAFLEKYRALHGTGFLASKYASPYSGDPKQALSEGPPSPWTQLAQPLGPACQDAAPPHYPLPHPTQPVPCPPACRHPEKPGSYSSVLPLQPLGAPKGAGYPAGGLNSPYLRQQAIQTPYMPPVGLDPYAYPSAPLPAPSPGLKLEPPLTPRCPLDFAPQTLGFPYAREDLSLYGASPGLGGMPPSQNSVQALPKPGAFQRACQPLPASRPCSEPMRPAEKPVQEAEEKMWLPSCRKEHPQPQPQAQPQPQPPPRLDEHPGAPIVIGDSPVPRTPPPLPPCAQERQSLPQNEGSLPPSSPPMPVIDNVFSLAPYRDYLDVPAPEAPAEPELAPAPNESHDRDCGRSLPAQEAPSSEHPSLKEEVALDLSVKKTTAEASPTKVPHPMGRAKPTAAVDMPATGSNVSNVPGTGDTVSDPQGLQKAVTEVPEPPGLPVTTEATPRTNFHSSVAFMFRKFKIIRPAPLPATVVPSVPTLAPAPAQPVPTPTPVPPGLQMLTQPLPMACFGLTLPSPPAVAMASPASMPAPAPSPAPAPAPAPAPVAGPSPASTPTTADSSEQHFAGLHASLCDAISGSVAHSPPEKLREWLATSGPWGRAAWQDCQGVQGLLGKLLSQLQSFVCTQQCPFPHVVRAGAIFVPIHLVKERLFPRLPPASVDHVLQEHRVELRPTTLSEERALRERALHGCTSRMLKLLALRQLPDIYPDLLGLQWRDCVRRQLGDFNTEPGSVPSSESTMAREEPGSLDLTWKSAAPKAKKPGRKPPTPGPEKAEATAAGGSRGASPTPAAGASLPGPTVKARFRSLLESAWLNGLALPTWGHKASGPDRTAPRPQLLGSQSHQL", "length": 1189, "header": "tr|A0AAA9SME3-1|A0AAA9SME3_BOVIN Isoform 1 of Chromosome 21 C15orf39 homolog OS=Bos taurus OX=9913 GN=C21H15orf39 PE=4 SV=1 CANONICAL=A0AAA9SME3-1" }, "locus": { "chromosome": "21", "start_pos": 33553992, "end_pos": 33543464, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108455.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108455.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083920.1" } ] } }, { "isoform_ac": "E1BCK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3/entry#E1BCK2-1", "sequence": { "sequence": "MAEKRPLGTLGPVMYGKLPRLEADSGPGHSLPPSAGNQDSCSYKGAYFSCPMGAPPKTGSERLAPWTPYPPLYPTSMAGPPLRANNLLTSCLLYRPSTESSEKVQDSGPVELLPFGPQSHSYPGPPLAAPKPVYRSPLCYGLATCLGAGAPKKPLDVDWTLVTGSLLPPVGPSCSLPPASGKGQFLDGTFLRGVPAGASDKDSSVSFSPCQAFLEKYRALHGTGFLASKYASPYSGDPKQALSEGPPSPWTQLAQPLGPACQDAAPPHYPLPHPTQPVPCPPACRHPEKPGSYSSVLPLQPLGAPKGAGYPAGGLNSPYLRQQAIQTPYMPPVGLDPYAYPSAPLPAPSPGLKLEPPLTPRCPLDFAPQTLGFPYAREDLSLYGASPGLGGMPPSQNSVQALPKPGAFQRACQPLPASRPCSEPMRPAEKPVQEAEEKMWLPSCRKEHPQPQPQAQPQPQPPPRLDEHPGAPIVIGDSPVPRTPPPLPPCAQERQSLPQNEGSLPPSSPPMPVIDNVFSLAPYRDYLDVPAPEAPAEPELAPAPNESHDRDCGRSLPAQEAPSSEHPSLKEEVALDLSVKKTTAEASPTKVPHPMGRAKPTAAVDMPATGSNVSNVPGTGDTVSDPQGLQKAVTEVPEPPGLPVTTEATPRTNFHSSVAFMFRKFKIIRPAPLPATVVPSVPTLAPAPAQPVPTPTPVPPGLQMLTQPLPMACFGLTLPSPPAVAMASPASMPAPAPSPAPAPAPAPAPVAGPSPASTPTTADSSEQHFAGLHASLCDAISGSVAHSPPEKLREWLATSGPWGRAAWQDCQGVQGLLGKLLSQLQSFVCTQQCPFPHVVRAGAIFVPIHLVKERLFPRLPPASVDHVLQEHRVELRPTTLSEERALRERALHGCTSRMLKLLALRQLPDIYPDLLGLQWRDCVRRQLGDFNTEPGSVPSSESTMAREEPGSLDLTWKSAAPKAKKPGRKPPTPGPEKAEATAAGGSRGASPTPAAGASLPGPTVKARFRSLLESAWLNGLALPTWGHKASGPDRTAPRPQLLGSQSHQL", "length": 1049, "header": "tr|E1BCK2-1|E1BCK2_BOVIN Computationally mapped isoform of Chromosome 21 C15orf39 homolog OS=Bos taurus OX=9913 GN=C21H15orf39 PE=4 SV=3 CANONICAL=A0AAA9SME3-1" }, "locus": { "chromosome": "21", "start_pos": 33548530, "end_pos": 33543464, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027992.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027992.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027992.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027992.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1112, "start_aa": "Thr", "end_pos": 1112, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1112", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1132, "start_aa": "Thr", "end_pos": 1132, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1132", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1143, "start_aa": "Thr", "end_pos": 1143, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1143", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 834, "start_aa": "Thr", "end_pos": 834, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr834", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 836, "start_aa": "Thr", "end_pos": 836, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr836", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SME3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 685, "end_pos": 687, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 834, 836, 1112, 1132, 1143 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 685, "end_pos": 687 }, { "start_pos": 752, "end_pos": 754 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMF9-1", "uniprot_ac": "A0AAA9SMF9", "uniprot_id": "A0AAA9SMF9_BOVIN", "mass": { "chemical_mass": 67577.0, "monoisotopic_mass": 67577.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101905790", "type": "recommended", "evidence": [ { "id": "A0AAA9SMF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ] } ], "protein_names": [ { "name": "Zinc finger protein 852", "type": "recommended", "evidence": [ { "id": "A0AAA9SMF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MMV1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMV1#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9#function" }, { "database": "UniProtKB", "id": "A0AAA9TX32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX32#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101905790", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SMF9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052626", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052626", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HHLKAWF", "url": "https://omabrowser.org/oma/group/HHLKAWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MMV1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLSSRSLSFQEATELEFLSVNYTLKNWKGTALSQRALYWNIMLENCCSLAPLAGENRMASSQLSPKQDISEESKSADRTSGILCGLILRGPEAGASCEEALEKLKVQPSDEEGTRRESDFLEITQEDKKKSTKDRCDEYKELGGHPDLSSTLSKHQGVLKGQKLYRCDECGKVFNWSSHLIGHQRIHTGEKPYECTECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHTGEKPYKCNECGKAFNESSKLFDHQRTHTGEKPYGCNECGALFSRSKSLIRHQVLHTGKKPYKCEECGKAFCSNRNLIDHQRIHTGEKPYECNECGKAFSRSKCLTRHQSLHTGKKPYKCSKCVKAFNQISQLADHERIHTGEKPFECNECGKAFSLSKCLTRHQRLHTGEKPYKCNDCGKSFNQNSYLIIHQRIHTGEKPYECNKCGKVFTHNSSLMVHQRTHTGEKPYKCKDCEKAFRDSSQLTVHQRVHTGEKPYECIECGKPLVSVLLSITTSELTLERSTQVWLGLFVKTRFSKTARNFRLRFLYKYVHPDLYLEPPVPCVPSQDFPRGPVVKALSSQNGGHEF", "length": 593, "header": "tr|A0AAA9SMF9-1|A0AAA9SMF9_BOVIN Isoform 1 of Zinc finger protein 852 OS=Bos taurus OX=9913 GN=LOC101905790 PE=3 SV=1 CANONICAL=A0AAA9SMF9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9/entry#A0A3Q1MMV1-1", "sequence": { "sequence": "MASSQLSPKQDISEESKSADRTSGILCGLILRGPEAGASCEEALEKLKVQPSDEEGTRRESDFLEITQEDKKKSTKDRCDEYKELGGHPDLSSTLSKHQGVLKGQKLYRCDECGKVFNWSSHLIGHQRIHTGEKPYECTECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHTGEKPYKCNECGKAFNESSKLFDHQRTHTGEKPYGCNECGALFSRSKSLIRHQVLHTGKKPYKCEECGKAFCSNRNLIDHQRIHTGEKPYECNECGKAFSRSKCLTRHQSLHTGKKPYKCSKCVKAFNQISQLADHERIHTGEKPFECNECGKAFSLSKCLTRHQRLHTGEKPYKCNDCGKSFNQNSYLIIHQRIHTGEKPYECNKCGKVFTHNSSLMVHQRTHTGEKPYKCKDCEKAFRDSSQLTVHQRVHTGEKPYECIECGKPLVSVLLSITTSELTLERSTQVWLGLFVKTRFSKTARNFRLRFLYKYVHPDLYLEPPVPCVPSQDFPRGPVVKALSSQNGGHEF", "length": 535, "header": "tr|A0A3Q1MMV1-1|A0A3Q1MMV1_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC101905790 PE=3 SV=2 CANONICAL=A0AAA9SMF9-1" }, "locus": { "chromosome": "22", "start_pos": 16376469, "end_pos": 16374865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086521.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086521.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070798.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070798.2" } ] } }, { "isoform_ac": "A0AAA9SMF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9/entry#A0AAA9SMF9-1", "sequence": { "sequence": "MSLSSRSLSFQEATELEFLSVNYTLKNWKGTALSQRALYWNIMLENCCSLAPLAGENRMASSQLSPKQDISEESKSADRTSGILCGLILRGPEAGASCEEALEKLKVQPSDEEGTRRESDFLEITQEDKKKSTKDRCDEYKELGGHPDLSSTLSKHQGVLKGQKLYRCDECGKVFNWSSHLIGHQRIHTGEKPYECTECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHTGEKPYKCNECGKAFNESSKLFDHQRTHTGEKPYGCNECGALFSRSKSLIRHQVLHTGKKPYKCEECGKAFCSNRNLIDHQRIHTGEKPYECNECGKAFSRSKCLTRHQSLHTGKKPYKCSKCVKAFNQISQLADHERIHTGEKPFECNECGKAFSLSKCLTRHQRLHTGEKPYKCNDCGKSFNQNSYLIIHQRIHTGEKPYECNKCGKVFTHNSSLMVHQRTHTGEKPYKCKDCEKAFRDSSQLTVHQRVHTGEKPYECIECGKPLVSVLLSITTSELTLERSTQVWLGLFVKTRFSKTARNFRLRFLYKYVHPDLYLEPPVPCVPSQDFPRGPVVKALSSQNGGHEF", "length": 593, "header": "tr|A0AAA9SMF9-1|A0AAA9SMF9_BOVIN Isoform 1 of Zinc finger protein 852 OS=Bos taurus OX=9913 GN=LOC101905790 PE=3 SV=1 CANONICAL=A0AAA9SMF9-1" }, "locus": { "chromosome": "22", "start_pos": 16378625, "end_pos": 16374865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127758.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127758.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083941.1" } ] } }, { "isoform_ac": "A0AAA9TX32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9/entry#A0AAA9TX32-1", "sequence": { "sequence": "MLENCCSLAPLAGENRMASSQLSPKQDISEESKSADRTSGILCGLILRGPEAGASCEEALEKLKVQPSDEEGTRRESDFLEITQEDKKKSTKDRCDEYKELGGHPDLSSTLSKHQGVLKGQKLYRCDECGKVFNWSSHLIGHQRIHTGEKPYECTECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHTGEKPYKCNECGKAFNESSKLFDHQRTHTGEKPYGCNECGALFSRSKSLIRHQVLHTGKKPYKCEECGKAFCSNRNLIDHQRIHTGEKPYECNECGKAFSRSKCLTRHQSLHTGKKPYKCSKCVKAFNQISQLADHERIHTGEKPFECNECGKAFSLSKCLTRHQRLHTGEKPYKCNDCGKSFNQNSYLIIHQRIHTGEKPYECNKCGKVFTHNSSLMVHQRTHTGEKPYKCKDCEKAFRDSSQLTVHQRVHTGEKPYECIECGKPLVSVLLSITTSELTLERSTQVWLGLFVKTRFSKTARNFRLRFLYKYVHPDLYLEPPVPCVPSQDFPRGPVVKALSSQNGGHEF", "length": 551, "header": "tr|A0AAA9TX32-1|A0AAA9TX32_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC101905790 PE=3 SV=1 CANONICAL=A0AAA9SMF9-1" }, "locus": { "chromosome": "22", "start_pos": 16378499, "end_pos": 16374865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101152.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101152.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q6ZMS4-1", "protein_name": "Zinc finger protein 852", "gene_name": "ZNF852", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRPQDTVAYEDLSEDYTQKKWKGLALSQRALHWNMMLENDRSMASLGRNMMESSELTPKQEIFKGSESSNSTSGGLFGVVPGGTETGDVCEDTFKELEGQPSNEEGSRLESDFLEIIDEDKKKSTKDRYEEYKEVEEHPPLSSSPVEHEGVLKGQKSYRCDECGKAFYWSSHLIGHRRIHTGEKPYECNECGKTFRQTSQLIVHLRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFNQSSKLFDHQRTHTGEKPYECKECGAAFSRSKNLVRHQFLHTGKKPYKCNECGRAFCSNRNLIDHQRTHTGEKPYKCNECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQISQLVEHERIHTGEKPFKCSECGKAFGLSKCLIRHQRLHTSEKPYKCNECGKSFNQNSYLIIHQRIHTGEKPYECNECGKVFSYNSSLMVHQRTHTGEKPYKCNSCGKAFSDSSQLTVHQRVHTGEKNLMNVLSVGKPLVSVPLLITTSELMLERSPQVWLGHLLKAWFSETDSKDL", "length": 543 }, "evidence": [ { "id": "A0AAA9SMF9", "url": "https://omabrowser.org/oma/group/A0AAA9SMF9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "regulation of macromolecule metabolic process", "id": "GO:0060255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 193, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMF9" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 87, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 22, "end_pos": 24 }, { "start_pos": 260, "end_pos": 262 }, { "start_pos": 458, "end_pos": 460 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMG5-1", "uniprot_ac": "A0AAA9SMG5", "uniprot_id": "A0AAA9SMG5_BOVIN", "mass": { "chemical_mass": 36084.0, "monoisotopic_mass": 36084.0 }, "refseq": { "ac": "XP_005211334", "name": "alpha- and gamma-adaptin-binding protein p34 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211334" }, "gene_names": [ { "name": "AAGAB", "type": "recommended", "evidence": [ { "id": "A0AAA9SMG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5" } ] }, { "name": "AAGAB", "type": "synonym", "evidence": [ { "id": "XP_005211334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211334" } ] } ], "protein_names": [ { "name": "Alpha- and gamma-adaptin-binding protein p34", "type": "recommended", "evidence": [ { "id": "A0AAA9SMG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5/entry#names_and_taxonomy" } ] }, { "name": "alpha- and gamma-adaptin-binding protein p34 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005211334", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211334" } ] } ], "function": [ { "annotation": "May be involved in endocytic recycling of growth factor receptors such as EGFR.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5#function" }, { "database": "UniProtKB", "id": "ARBA00059083", "url": "https://www.uniprot.org/uniprotkb/ARBA00059083#function" }, { "database": "UniProtKB", "id": "A0AAF6DMB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AAGAB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5", "locus": { "chromosome": "10", "start_pos": 14030086, "end_pos": 14103131, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040368", "url": "https://www.ensembl.org/id/ENSBTAG00000040368" } ] } } ], "crossref": [ { "id": "A0AAA9SMG5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "507035", "url": "https://www.ncbi.nlm.nih.gov/gene/507035", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14659", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14659", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14659:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14659:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10199", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10199", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211334", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211334", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMB2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGVPCALVTSCSSTFSADRLVQHILGTEDVVVEVTANDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAESWLPEVMILVCDRVSENGVNRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNERNQGLNLLSSLTGASHSIGSAESCHSEQPCVPAAERTESLLDHRGAASNTADVQVDSIVDPMLDLDIQELASLTTGGGDLENFERLFSKLKEMKVLEHLCAPDSPVRLDEFLKIYFPPRQGCDASSRAKKDACRKGGQSLLDGNWGRQR", "length": 328, "header": "tr|A0AAA9SMG5-1|A0AAA9SMG5_BOVIN Isoform 1 of Alpha- and gamma-adaptin-binding protein p34 OS=Bos taurus OX=9913 GN=AAGAB PE=4 SV=1 CANONICAL=A0AAA9SMG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5/entry#A0AAA9SMG5-1", "sequence": { "sequence": "MAAGVPCALVTSCSSTFSADRLVQHILGTEDVVVEVTANDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAESWLPEVMILVCDRVSENGVNRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNERNQGLNLLSSLTGASHSIGSAESCHSEQPCVPAAERTESLLDHRGAASNTADVQVDSIVDPMLDLDIQELASLTTGGGDLENFERLFSKLKEMKVLEHLCAPDSPVRLDEFLKIYFPPRQGCDASSRAKKDACRKGGQSLLDGNWGRQR", "length": 328, "header": "tr|A0AAA9SMG5-1|A0AAA9SMG5_BOVIN Isoform 1 of Alpha- and gamma-adaptin-binding protein p34 OS=Bos taurus OX=9913 GN=AAGAB PE=4 SV=1 CANONICAL=A0AAA9SMG5-1" }, "locus": { "chromosome": "10", "start_pos": 14103106, "end_pos": 14030738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097764.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097764.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086487.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086487.1" } ] } }, { "isoform_ac": "A0AAF6DMB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5/entry#A0AAF6DMB2-1", "sequence": { "sequence": "MAAGVPCALVTSCSSTFSADRLVQHILGTEDVVVEVTANDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAESWLPEVMILVCDRVSENGVNRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNGKRNKEIERNQGLNLLSSLTGASHSIGSAESCHSEQPCVPAAERTESLLDHRGAASNTADVQVDSIVDPMLDLDIQELASLTTGGGDLENFERLFSKLKEMKDKAATLPHEQRKMHAEKVAKAFWMAIGGDRDEIEGLSSDEEH", "length": 322, "header": "tr|A0AAF6DMB2-1|A0AAF6DMB2_BOVIN Computationally mapped isoform of Alpha- and gamma-adaptin-binding protein p34 OS=Bos taurus OX=9913 GN=AAGAB PE=4 SV=1 CANONICAL=A0AAA9SMG5-1" }, "locus": { "chromosome": "10", "start_pos": 14103106, "end_pos": 14030704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055091.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055091.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050312.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050312.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMI1-1", "uniprot_ac": "A0AAA9SMI1", "uniprot_id": "A0AAA9SMI1_BOVIN", "mass": { "chemical_mass": 396470.0, "monoisotopic_mass": 396470.0 }, "refseq": { "ac": "XP_024834681", "name": "zinc finger protein 469", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834681" }, "gene_names": [ { "name": "ZNF469", "type": "recommended", "evidence": [ { "id": "A0AAA9SMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1" } ] }, { "name": "ZNF469", "type": "synonym", "evidence": [ { "id": "XP_024834681", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834681" } ] } ], "protein_names": [ { "name": "Zinc finger protein 469", "type": "synonym", "evidence": [ { "id": "A0AAA9SMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 469", "type": "synonym", "evidence": [ { "id": "XP_024834681", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834681" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF469", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1", "locus": { "chromosome": "18", "start_pos": 13713392, "end_pos": 13461104, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045507", "url": "https://www.ensembl.org/id/ENSBTAG00000045507" } ] } } ], "crossref": [ { "id": "100298623", "url": "https://www.ncbi.nlm.nih.gov/gene/100298623", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100298623", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100298623", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR21465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21465:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21465:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834681", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834681", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGEQPLGTPPPTMTGDLQPCPAASGTGGPLRPPGEISALANRTTKAMGSRAQATDDPKAQVQQAGKGLTEAPLPRAQALSSVPSKGSSPQTPAGSNLMQARVRRAGRVAGSPQQLYSLNIASTRPKPALDGKTPESLQPEDLRPLNAEAPPSQGTRAGLRPGHPRAEASPAPEELSFQKCFQETPSSFTSTNYTSPSATPGPPPLRAPQSRGTSPCRPASYLEFQASGADAWPPPAENSFPGASFGVPPTEPEPFPEGGSPGVAAFQYPFPELHGAGRRPFPEDTAGPKYPERALVLAFHQPRGAWPEAVGTGPAYPLAARPARPPPPCYSSRPGSLEAPSDLGGVPPPPSAAPPAPKPFSESTATFQDGLHENMTKVLPERPPSAHEGLGSPRGPPNSLSQRQFPGQAYGSPGASGVGTSPGPRDTELAASGPPTARLPPLWDPAPAPYPPPPLGPPATTFFEAQPSPGQQLSLPQSPPLPWPQVLPATGPSPHQMEMLNRLPFPPGAPEWQGGSQGALGAVGKTPGPGEKLAVLRNSPGQHGSGSPGLFAYNGLKDPGAQPLFFGAAQPQASPRGPPGLPPPRVVGASPSESPLPSPATHTASSTCSSLSPLSSSPANPSSDESQVPGPLVPSAFFHPAPHPQEAGSPFPSPEPSHSLPIHYQPEPAKTFPFPTEGLEETPFPSSGLQVGSAGLEGFPQGPPPYSTHHFPLSSASLDQLDVLLTCRQCDRNYSSLAAFLGHRQFCGLLPARAQDSHQQPPGLPAPPRVPAGRTPSPLSHARTAPFLLGGDLRPDGRDDPLRTSFLPGPTATPFPLPTGDLDLEDAAKLDSLITEALNGLEYQSDNPEIDSSFIDVFTDEEPSGPKGSAAGQPPKARLGATPENKAPAPALPPAVDVPLETQPRQPGDGGNPAGPRPKTRSLGPAPAETDGASLAGQQRRGKRFKLFRKELDTVNTTKRPGRGSRATRLRPRRKGRAEARPRDLRTQAPKSHTDPGGRAPLVETRSSRRLRLSPGQDCRRRRARGGTWSKELIHKIVQQKNRAGGRGPAPGAADGGPQHCDCAASESEEEDGPRPPGSRFRGRPRPSGRRWRRGEKRKEVDLTPGVREDGQQQKPRKVVKQEAARSRGYLGPEEPGRPGPGPSQSPGAQGPSHGPEAGVDLEEKGPQHLLRDLIGTKTVEESHPPPGFPQDTETPEVADGLPPDATELHKEAPGSSPAPCRGGGPCPSAPELPQLHGEDAGLPLASSPTLGARRCLEPVASQDREDPPASPSGESLVPVANAVHMVHLDPSTLFVKTPGLGESIEAPAARKGPKPYSSPHSELFLGPKDLASCFHEDLGSRASAPDSPLAIRAHLCQDNHDASSPEPKPPRSPPYTGITDPGRGQSALALEPTPLPLGLPRDNFDPPPYGSLSGRGDTPALRACAALPPRKPQLDPPYPSFLPERDWSLLEEVSPVPPGHPGLFPGLSAEKTLSQQCPSEGPVAASLSALPTRAVECSTASTSDLSEEELEIKRLVTELESQLQSRGPQGARGEPCRASNTAPRDSSSHGKGVDTRGDALASPQEEWPSPLAPSTHKDMVPQGPSSPMGASLSFQSVQKARVPKTRLPRAEGGQRARQEVCVPDPMSDVGSLAKCSPSLEPSLPKGHGAPGTQHSQGLPLLLPHPPRGGVSPGPHKAPGPCQDPLELEAFSSPTTHLAPGLAYRGAELLPLGTTPPSAAIHSSAPRGHSVSSTGEPGGTELLPAVTAGPVPEGKEEFVPVGVSPSCASIPNPSPGGRLQNPASSPLHQLQLLVARAAERGDDARGSRVTPTAEAQSPLHSNPSDVGGDGKEGETVAHSPALGSLGDVQMTTVARHQLEPDEDGHVGTLGQARKPRGQAEAGHLQPGDQGRPGGPDSCTTASADPETTPAGLVGAADQLGAQLQGSRAAMGLCNKAQATPSPTSSEADSSVPALVAAHTPDRPRDWTLEAVAAGPGLRKHLLFPGESPEPPTRDLASRTPSSASAAPSNPCGLKPLHQEGPSAAPSGELGELLPASPSHRGAASSQLLSASSPTWTPPEGAERSPATTCTVAPLAVSPSLKTSHHGLKESPAHHPLLGDGSPLEDPPKEPSFVSVISAAHGGARPGGHVSKTLEASRKERPRDSPAHATPPHPTTVSTPGATVKAAALPSVPITDGLGALRGPRAEWPDPRGVLPITHPDGVPTGSSSKPLGNREGQGVTTVPTDPSTRGAMWPDPHTCQEGKALASLQGQESLETPGARLPAITKASEAGARGVPVMCPPTELCPGSTTSDSRALFPQCALHQRPQADALSPQDLRQKPRGFKKKPVFTENGHWRGGAPSGRPVTCEVCSASFRSGPGLSRHRARKHGLHKGATSQPSPAPQPAPQMCHRPGKKSRRALGKEEAGRLVGDPSQAGEPPPVCGSTPPEDALGPETSKGLRQGLSLLGAPGCPPSWEPHTPDTIRQGVDVKPAEPRKQDRLGREELRPKQAEKGGGQRRGRPHTDFPSESEGKSNKKARKPRARRFREESNPQAPANVTPDRSCWSPSTSAANCCRLSPKTEQETKATQLSPAAMDLEETPAQKPPGDWVACSRMVEGAPPGEGPGEQKAALAGGCGGPRETRTSGICEEPLRVTGAKPAGDSREADSRLGHSVLEEHGLPRGPPETRGSEAGGTISSPCSQAPLHSPAEGVPEQEGTAPKPPSPERGDPLSLLDDEASFSQLFPLGDRLARKKNPRVYGKRCKKSKPPPRVEPSGQVGGSVTLPSARLPTDLSDSGSLCLSHEDPWGDEATDLPESFLLEGFLNSKVPGIDPWAPGPSLWALEPHLETKPCRAEDHPSENIPKLHMVPAAWRGLELQAPEDEVTSSLGDASPEPPNLEREHYDGGVPRSAADLEMLGTKLELQDLSFLGPCEDPVGLPSTSFLDVKATAGSQGPRSRTEEADGARKAAGEGQHAKARRASYKCRVCFQRFHGLGELDLHKLAHSPSPPPTCYMCVERRFGSRELLREHLLEKHVQSKAGLWACGMCLREVADVWMYNEHLREHAVRFARKGQARRSLEDLPACWEGGGVVTHFLSGIAGQASRSHRGKRSVAGKVGGGCAESSGPNAGARKALPRERPRPQARSRGCDAVGASAQGSPSACARPAPAGGASPEAHPHGEPPLPAVPVHQDCKDPARDCHHCGKRFPKPFKLQRHLAVHSPQRVYLCPQCPRVYPEHQELRAHLGSEHGVSGELELAHTPLYACELCANVTHISKRSFVCSSCNYTFAKKEQFDRHMDKHRRKGQQPFTFRGVRRPGAPGRKASAREGTLPSKRRRVAAPGSPARSSTDGPLSQGSSPTPSEGSLPALLQPCPEAAPSVTAGQPGTPERPIDPLGHQELLPPSLSPFPAASAGGKDGHKPDQALESSEDEASPGSPEHLLQKAFPLGGSLPRLGAADHEVEEKRAAGPLSGKHRTPSAPGKCAPDHHPEAPSLLWKEKQVSTCLLVPAGATGGPSHRGSAPKPRGCGSLSKDRSSSSTPNKAPKIPGQLKKAVASPVPGELPRGTEERLKPTALKAKPGFQGAGGPRQGTKAVGGSQPQPASGRLQSETATTPAKPDCPGQGPAPDKALPRALAKGYPKGPREAGGQGLRGSLGPREDADSSEKKRKGRAPEPARSEGVGSLGKGPSAPDKPPRAPRKQATPSRVIPAKPKPKPKSSSQNSSMLPQPSEVQKREPSHAHGDLRCSKEGLSKALPQTRPLHRPPRKGGALHSAEPPNPRACRTAESQSHLLSQLFGQRLTSFKIPLKKDSSE", "length": 3791, "header": "tr|A0AAA9SMI1-1|A0AAA9SMI1_BOVIN Isoform 1 of Zinc finger protein 469 OS=Bos taurus OX=9913 GN=ZNF469 PE=4 SV=1 CANONICAL=A0AAA9SMI1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1/entry#A0AAA9SMI1-1", "sequence": { "sequence": "MPGEQPLGTPPPTMTGDLQPCPAASGTGGPLRPPGEISALANRTTKAMGSRAQATDDPKAQVQQAGKGLTEAPLPRAQALSSVPSKGSSPQTPAGSNLMQARVRRAGRVAGSPQQLYSLNIASTRPKPALDGKTPESLQPEDLRPLNAEAPPSQGTRAGLRPGHPRAEASPAPEELSFQKCFQETPSSFTSTNYTSPSATPGPPPLRAPQSRGTSPCRPASYLEFQASGADAWPPPAENSFPGASFGVPPTEPEPFPEGGSPGVAAFQYPFPELHGAGRRPFPEDTAGPKYPERALVLAFHQPRGAWPEAVGTGPAYPLAARPARPPPPCYSSRPGSLEAPSDLGGVPPPPSAAPPAPKPFSESTATFQDGLHENMTKVLPERPPSAHEGLGSPRGPPNSLSQRQFPGQAYGSPGASGVGTSPGPRDTELAASGPPTARLPPLWDPAPAPYPPPPLGPPATTFFEAQPSPGQQLSLPQSPPLPWPQVLPATGPSPHQMEMLNRLPFPPGAPEWQGGSQGALGAVGKTPGPGEKLAVLRNSPGQHGSGSPGLFAYNGLKDPGAQPLFFGAAQPQASPRGPPGLPPPRVVGASPSESPLPSPATHTASSTCSSLSPLSSSPANPSSDESQVPGPLVPSAFFHPAPHPQEAGSPFPSPEPSHSLPIHYQPEPAKTFPFPTEGLEETPFPSSGLQVGSAGLEGFPQGPPPYSTHHFPLSSASLDQLDVLLTCRQCDRNYSSLAAFLGHRQFCGLLPARAQDSHQQPPGLPAPPRVPAGRTPSPLSHARTAPFLLGGDLRPDGRDDPLRTSFLPGPTATPFPLPTGDLDLEDAAKLDSLITEALNGLEYQSDNPEIDSSFIDVFTDEEPSGPKGSAAGQPPKARLGATPENKAPAPALPPAVDVPLETQPRQPGDGGNPAGPRPKTRSLGPAPAETDGASLAGQQRRGKRFKLFRKELDTVNTTKRPGRGSRATRLRPRRKGRAEARPRDLRTQAPKSHTDPGGRAPLVETRSSRRLRLSPGQDCRRRRARGGTWSKELIHKIVQQKNRAGGRGPAPGAADGGPQHCDCAASESEEEDGPRPPGSRFRGRPRPSGRRWRRGEKRKEVDLTPGVREDGQQQKPRKVVKQEAARSRGYLGPEEPGRPGPGPSQSPGAQGPSHGPEAGVDLEEKGPQHLLRDLIGTKTVEESHPPPGFPQDTETPEVADGLPPDATELHKEAPGSSPAPCRGGGPCPSAPELPQLHGEDAGLPLASSPTLGARRCLEPVASQDREDPPASPSGESLVPVANAVHMVHLDPSTLFVKTPGLGESIEAPAARKGPKPYSSPHSELFLGPKDLASCFHEDLGSRASAPDSPLAIRAHLCQDNHDASSPEPKPPRSPPYTGITDPGRGQSALALEPTPLPLGLPRDNFDPPPYGSLSGRGDTPALRACAALPPRKPQLDPPYPSFLPERDWSLLEEVSPVPPGHPGLFPGLSAEKTLSQQCPSEGPVAASLSALPTRAVECSTASTSDLSEEELEIKRLVTELESQLQSRGPQGARGEPCRASNTAPRDSSSHGKGVDTRGDALASPQEEWPSPLAPSTHKDMVPQGPSSPMGASLSFQSVQKARVPKTRLPRAEGGQRARQEVCVPDPMSDVGSLAKCSPSLEPSLPKGHGAPGTQHSQGLPLLLPHPPRGGVSPGPHKAPGPCQDPLELEAFSSPTTHLAPGLAYRGAELLPLGTTPPSAAIHSSAPRGHSVSSTGEPGGTELLPAVTAGPVPEGKEEFVPVGVSPSCASIPNPSPGGRLQNPASSPLHQLQLLVARAAERGDDARGSRVTPTAEAQSPLHSNPSDVGGDGKEGETVAHSPALGSLGDVQMTTVARHQLEPDEDGHVGTLGQARKPRGQAEAGHLQPGDQGRPGGPDSCTTASADPETTPAGLVGAADQLGAQLQGSRAAMGLCNKAQATPSPTSSEADSSVPALVAAHTPDRPRDWTLEAVAAGPGLRKHLLFPGESPEPPTRDLASRTPSSASAAPSNPCGLKPLHQEGPSAAPSGELGELLPASPSHRGAASSQLLSASSPTWTPPEGAERSPATTCTVAPLAVSPSLKTSHHGLKESPAHHPLLGDGSPLEDPPKEPSFVSVISAAHGGARPGGHVSKTLEASRKERPRDSPAHATPPHPTTVSTPGATVKAAALPSVPITDGLGALRGPRAEWPDPRGVLPITHPDGVPTGSSSKPLGNREGQGVTTVPTDPSTRGAMWPDPHTCQEGKALASLQGQESLETPGARLPAITKASEAGARGVPVMCPPTELCPGSTTSDSRALFPQCALHQRPQADALSPQDLRQKPRGFKKKPVFTENGHWRGGAPSGRPVTCEVCSASFRSGPGLSRHRARKHGLHKGATSQPSPAPQPAPQMCHRPGKKSRRALGKEEAGRLVGDPSQAGEPPPVCGSTPPEDALGPETSKGLRQGLSLLGAPGCPPSWEPHTPDTIRQGVDVKPAEPRKQDRLGREELRPKQAEKGGGQRRGRPHTDFPSESEGKSNKKARKPRARRFREESNPQAPANVTPDRSCWSPSTSAANCCRLSPKTEQETKATQLSPAAMDLEETPAQKPPGDWVACSRMVEGAPPGEGPGEQKAALAGGCGGPRETRTSGICEEPLRVTGAKPAGDSREADSRLGHSVLEEHGLPRGPPETRGSEAGGTISSPCSQAPLHSPAEGVPEQEGTAPKPPSPERGDPLSLLDDEASFSQLFPLGDRLARKKNPRVYGKRCKKSKPPPRVEPSGQVGGSVTLPSARLPTDLSDSGSLCLSHEDPWGDEATDLPESFLLEGFLNSKVPGIDPWAPGPSLWALEPHLETKPCRAEDHPSENIPKLHMVPAAWRGLELQAPEDEVTSSLGDASPEPPNLEREHYDGGVPRSAADLEMLGTKLELQDLSFLGPCEDPVGLPSTSFLDVKATAGSQGPRSRTEEADGARKAAGEGQHAKARRASYKCRVCFQRFHGLGELDLHKLAHSPSPPPTCYMCVERRFGSRELLREHLLEKHVQSKAGLWACGMCLREVADVWMYNEHLREHAVRFARKGQARRSLEDLPACWEGGGVVTHFLSGIAGQASRSHRGKRSVAGKVGGGCAESSGPNAGARKALPRERPRPQARSRGCDAVGASAQGSPSACARPAPAGGASPEAHPHGEPPLPAVPVHQDCKDPARDCHHCGKRFPKPFKLQRHLAVHSPQRVYLCPQCPRVYPEHQELRAHLGSEHGVSGELELAHTPLYACELCANVTHISKRSFVCSSCNYTFAKKEQFDRHMDKHRRKGQQPFTFRGVRRPGAPGRKASAREGTLPSKRRRVAAPGSPARSSTDGPLSQGSSPTPSEGSLPALLQPCPEAAPSVTAGQPGTPERPIDPLGHQELLPPSLSPFPAASAGGKDGHKPDQALESSEDEASPGSPEHLLQKAFPLGGSLPRLGAADHEVEEKRAAGPLSGKHRTPSAPGKCAPDHHPEAPSLLWKEKQVSTCLLVPAGATGGPSHRGSAPKPRGCGSLSKDRSSSSTPNKAPKIPGQLKKAVASPVPGELPRGTEERLKPTALKAKPGFQGAGGPRQGTKAVGGSQPQPASGRLQSETATTPAKPDCPGQGPAPDKALPRALAKGYPKGPREAGGQGLRGSLGPREDADSSEKKRKGRAPEPARSEGVGSLGKGPSAPDKPPRAPRKQATPSRVIPAKPKPKPKSSSQNSSMLPQPSEVQKREPSHAHGDLRCSKEGLSKALPQTRPLHRPPRKGGALHSAEPPNPRACRTAESQSHLLSQLFGQRLTSFKIPLKKDSSE", "length": 3791, "header": "tr|A0AAA9SMI1-1|A0AAA9SMI1_BOVIN Isoform 1 of Zinc finger protein 469 OS=Bos taurus OX=9913 GN=ZNF469 PE=4 SV=1 CANONICAL=A0AAA9SMI1-1" }, "locus": { "chromosome": "18", "start_pos": 13713439, "end_pos": 13713392, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063301.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063301.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098042.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098042.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1811, "start_aa": "Thr", "end_pos": 1811, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1811", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1940, "start_aa": "Thr", "end_pos": 1940, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1940", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1944, "start_aa": "Thr", "end_pos": 1944, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1944", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 200, "start_aa": "Thr", "end_pos": 200, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr200", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 251, "start_aa": "Thr", "end_pos": 251, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr251", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3339, "start_aa": "Thr", "end_pos": 3339, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3339", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 527, "start_aa": "Thr", "end_pos": 527, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr527", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 812, "start_aa": "Thr", "end_pos": 812, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr812", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100298623", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100298623", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of extracellular matrix organization", "id": "GO:1903053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903053", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2537, "end_pos": 2539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3249, "end_pos": 3251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3264, "end_pos": 3266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3700, "end_pos": 3702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 734, "end_pos": 736, "annotation": "n_glycosylation_sequon" }, { "start_pos": 957, "end_pos": 959, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 2346, "end_pos": 2377, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 200, 251, 527, 812, 1811, 1940, 1944, 3339 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 193, "end_pos": 195 }, { "start_pos": 2537, "end_pos": 2539 }, { "start_pos": 3249, "end_pos": 3251 }, { "start_pos": 3264, "end_pos": 3266 }, { "start_pos": 3700, "end_pos": 3702 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 734, "end_pos": 736 }, { "start_pos": 957, "end_pos": 959 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMJ6-1", "uniprot_ac": "A0AAA9SMJ6", "uniprot_id": "A0AAA9SMJ6_BOVIN", "mass": { "chemical_mass": 78218.0, "monoisotopic_mass": 78218.0 }, "refseq": {}, "gene_names": [ { "name": "PTPRH", "type": "recommended", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ], "protein_names": [ { "name": "Receptor-type tyrosine-protein phosphatase H", "type": "recommended", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6/entry#names_and_taxonomy" } ] }, { "name": "Stomach cancer-associated protein tyrosine phosphatase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTPRH", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6", "locus": { "chromosome": "18", "start_pos": 62252166, "end_pos": 62236960, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040559", "url": "https://www.ensembl.org/id/ENSBTAG00000040559" } ] } } ], "crossref": [ { "id": "A0AAA9SMJ6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMJ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040559", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040559", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MGT8", "url": "https://www.orthodb.org/?gene=F1MGT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46957:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46957:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGT8", "url": "https://www.uniprot.org/uniprotkb/F1MGT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGT8-1", "url": "https://www.uniprot.org/uniprotkb/F1MGT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QTSSSITLSWKVPEGSEPETYCVQWTGDGNATVSQNTTNTTITVKGLEAGTLYEFSVYAVKDGFNSSVHLNACTDPLEKEMATHFSILAWEIPWTEEPGGLQSTGSQSRTRLDTHTPLPMPRYFRFALRRRRLGNHGFGVEGRGPWGSSPFSLYPYFSAPSEVTALQKQNQTDSSITLQWEAPADPQPQFYVYWVHWASRGYPQRKRGPQGHQDNQTGSTNRTHYTVEALVPGTWYCFNVWAESYGVHGYKQSLNASTAPDPANITSCVITSGGHEVILAWSCPQGGYEAFELEVKGQLGPQNSSSCGDAVKVSLLRPAQSSSATVMTVWDEMRAPSASVACHMESGHAGVIAGAVVSVLLLLILVGLLLFFLKRRQFKDSPFSPPSPHRFPGDILAEDFAEHVWRNERDSNYGFAEEYQQLALEDHGQSQTVASALENSGKNRYRNVLPYDWSRVPLQALLGQPGSEYINASFIPGLWSPREFIAAQGPLPQTVGDFWRMVWEQQSHTLVMLTNCVESGRVKCEHYWPLDAQPFTHGHLQVTLVGEEVAENWAVRNLKLCHVQQQKTLPVRQFHYMTWPDHGVPHSPDPLLAFWRMLRQWLDQTVGGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFGYVKKMRESRPLMVQTEAQYVFLHQCILQFLQQSATVRAQKGATYENLLMENGAATEA", "length": 702, "header": "tr|A0AAA9SMJ6-1|A0AAA9SMJ6_BOVIN Isoform 1 of Receptor-type tyrosine-protein phosphatase H OS=Bos taurus OX=9913 GN=PTPRH PE=4 SV=1 CANONICAL=A0AAA9SMJ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6/entry#A0AAA9SMJ6-1", "sequence": { "sequence": "QTSSSITLSWKVPEGSEPETYCVQWTGDGNATVSQNTTNTTITVKGLEAGTLYEFSVYAVKDGFNSSVHLNACTDPLEKEMATHFSILAWEIPWTEEPGGLQSTGSQSRTRLDTHTPLPMPRYFRFALRRRRLGNHGFGVEGRGPWGSSPFSLYPYFSAPSEVTALQKQNQTDSSITLQWEAPADPQPQFYVYWVHWASRGYPQRKRGPQGHQDNQTGSTNRTHYTVEALVPGTWYCFNVWAESYGVHGYKQSLNASTAPDPANITSCVITSGGHEVILAWSCPQGGYEAFELEVKGQLGPQNSSSCGDAVKVSLLRPAQSSSATVMTVWDEMRAPSASVACHMESGHAGVIAGAVVSVLLLLILVGLLLFFLKRRQFKDSPFSPPSPHRFPGDILAEDFAEHVWRNERDSNYGFAEEYQQLALEDHGQSQTVASALENSGKNRYRNVLPYDWSRVPLQALLGQPGSEYINASFIPGLWSPREFIAAQGPLPQTVGDFWRMVWEQQSHTLVMLTNCVESGRVKCEHYWPLDAQPFTHGHLQVTLVGEEVAENWAVRNLKLCHVQQQKTLPVRQFHYMTWPDHGVPHSPDPLLAFWRMLRQWLDQTVGGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFGYVKKMRESRPLMVQTEAQYVFLHQCILQFLQQSATVRAQKGATYENLLMENGAATEA", "length": 702, "header": "tr|A0AAA9SMJ6-1|A0AAA9SMJ6_BOVIN Isoform 1 of Receptor-type tyrosine-protein phosphatase H OS=Bos taurus OX=9913 GN=PTPRH PE=4 SV=1 CANONICAL=A0AAA9SMJ6-1" }, "locus": { "chromosome": "18", "start_pos": 62251372, "end_pos": 62236960, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090816.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090816.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083988.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083988.1" } ] } }, { "isoform_ac": "F1MGT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6/entry#F1MGT8-1", "sequence": { "sequence": "MIITYIWNRKNGSGNSLAIQGLGLKYSPFSPPSPHRFPGDILAEDFAEHVWRNERDSNYGFAEEYQQLALEDHGQSQTVASALENSGKNRYRNVLPYDWSRVPLQALLGQPGSEYINASFIPGLWSPREFIAAQGPLPQTVGDFWRMVWEQQSHTLVMLTNCVESGRVKCEHYWPLDAQPFTHGHLQVTLVGEEVAENWAVRNLKLCHVQQQKTLPVRQFHYMTWPDHGVPHSPDPLLAFWRMLRQWLDQTVGGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFGYVKKMRESRPLMVQTEAQYVFLHQCILQFLQQSATVRAQKGATYENLLMENGAATEA", "length": 348, "header": "tr|F1MGT8-1|A0AAA9SMJ6_BOVIN Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase H OS=Bos taurus OX=9913 GN=PTPRH PE=4 SV=4 CANONICAL=A0AAA9SMJ6-1" }, "locus": { "chromosome": "18", "start_pos": 62251372, "end_pos": 62245120, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052445.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052445.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050372.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050372.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" }, { "name": "microvillus membrane", "id": "GO:0031528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031528", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 471, "end_pos": 473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 77, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 592, "end_pos": 665, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" }, { "id": "PS50055", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50055" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 415, "end_pos": 674, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 221, "end_pos": 223 }, { "start_pos": 255, "end_pos": 257 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 30, "end_pos": 32 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 471, "end_pos": 473 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMK3-1", "uniprot_ac": "A0AAA9SMK3", "uniprot_id": "A0AAA9SMK3_BOVIN", "mass": { "chemical_mass": 18219.0, "monoisotopic_mass": 18219.0 }, "refseq": {}, "gene_names": [ { "name": "ZG16", "type": "recommended", "evidence": [ { "id": "A0AAA9SMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ] } ], "protein_names": [ { "name": "Zymogen granule membrane protein 16", "type": "recommended", "evidence": [ { "id": "A0AAA9SMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3/entry#names_and_taxonomy" } ] }, { "name": "Secretory lectin ZG16", "type": "synonym", "evidence": [ { "id": "A0AAA9SMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3#function" }, { "database": "UniProtKB", "id": "ARBA00054741", "url": "https://www.uniprot.org/uniprotkb/ARBA00054741#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZG16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3", "locus": { "chromosome": "25", "start_pos": 26459943, "end_pos": 26476226, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064482", "url": "https://www.ensembl.org/id/ENSBTAG00000064482" } ] } } ], "crossref": [ { "id": "A0AAA9SMK3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09611", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09611", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001229", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001229", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052321", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052321", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33589", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33589", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33589:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33589:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01419", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01419", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTAALLALLCASASATEIQPRASSYSGEYGGGGGERFSQSGNQLDGPITAIRIRVSNYYIVGLQVRYGTVWSDYVGGTSGDLDEIFLYPGESIVQVSGKYKTYLRKLVFVTDKFRFLSFGKDTGTSFNAVPLYPNTVLRFISGRAGSLIDAIGFHWDLYPSDYESC", "length": 167, "header": "tr|A0AAA9SMK3-1|A0AAA9SMK3_BOVIN Isoform 1 of Zymogen granule membrane protein 16 OS=Bos taurus OX=9913 GN=ZG16 PE=3 SV=1 CANONICAL=A0AAA9SMK3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3/entry#A0AAA9SMK3-1", "sequence": { "sequence": "MLTAALLALLCASASATEIQPRASSYSGEYGGGGGERFSQSGNQLDGPITAIRIRVSNYYIVGLQVRYGTVWSDYVGGTSGDLDEIFLYPGESIVQVSGKYKTYLRKLVFVTDKFRFLSFGKDTGTSFNAVPLYPNTVLRFISGRAGSLIDAIGFHWDLYPSDYESC", "length": 167, "header": "tr|A0AAA9SMK3-1|A0AAA9SMK3_BOVIN Isoform 1 of Zymogen granule membrane protein 16 OS=Bos taurus OX=9913 GN=ZG16 PE=3 SV=1 CANONICAL=A0AAA9SMK3-1" }, "locus": { "chromosome": "25", "start_pos": 26461714, "end_pos": 26460338, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125438.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125438.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086536.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086536.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 79, "start_aa": "Thr", "end_pos": 79, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr79", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mucus layer", "id": "GO:0070701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070701", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" }, { "name": "Golgi lumen", "id": "GO:0005796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peptidoglycan binding", "id": "GO:0042834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042834", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK3" }, { "id": "PS51752", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51752" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Jacalin-type lectin", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 159, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 79 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLN0-1", "uniprot_ac": "A0AAA9SLN0", "uniprot_id": "A0AAA9SLN0_BOVIN", "mass": { "chemical_mass": 26664.0, "monoisotopic_mass": 26664.0 }, "refseq": { "ac": "NP_001193835", "name": "ras-related protein Rab-23", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193835" }, "gene_names": [ { "name": "RAB23", "type": "recommended", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "name": "RAB23", "type": "synonym", "evidence": [ { "id": "NP_001193835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193835" } ] }, { "name": "Rab23-like", "type": "synonym", "evidence": [ { "id": "NP_001193835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193835" } ] } ], "protein_names": [ { "name": "Ras-related protein Rab-23", "type": "recommended", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#names_and_taxonomy" } ] }, { "name": "ras-related protein Rab-23", "type": "synonym", "evidence": [ { "id": "NP_001193835", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193835" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0", "locus": { "chromosome": "23", "start_pos": 3087632, "end_pos": 3012980, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005362", "url": "https://www.ensembl.org/id/ENSBTAG00000005362" } ] } } ], "crossref": [ { "id": "A0AAA9SLN0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04106", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04106", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618588", "url": "https://www.ncbi.nlm.nih.gov/gene/618588", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618588", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618588", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR47977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193835", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRTSVKEDLNVSEVFKYLAEKYLQKLKQQIAENPESMHSSSNKIGVFSTSAGSHLGQNSSTLNGGDVINLRPNRQRTKKNRNPFSSCSIP", "length": 237, "header": "tr|A0AAA9SLN0-1|A0AAA9SLN0_BOVIN Isoform 1 of Ras-related protein Rab-23 OS=Bos taurus OX=9913 GN=RAB23 PE=3 SV=2 CANONICAL=A0AAA9SLN0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#A0AAA9SDW4-1", "sequence": { "sequence": "MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRTSVKEDLNVSEVFKYLAEKYLQKLKQQIAENPESMHSSSNKIGKTGASLVSGTQGPWDQSLQSARDHHT", "length": 218, "header": "tr|A0AAA9SDW4-1|A0AAA9SLN0_BOVIN Computationally mapped isoform of Ras-related protein Rab-23 OS=Bos taurus OX=9913 GN=RAB23 PE=3 SV=1 CANONICAL=A0AAA9SLN0-1" }, "locus": { "chromosome": "23", "start_pos": 3047208, "end_pos": 3019772, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099169.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099169.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080566.1" } ] } }, { "isoform_ac": "A0AAA9SLN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#A0AAA9SLN0-1", "sequence": { "sequence": "MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRTSVKEDLNVSEVFKYLAEKYLQKLKQQIAENPESMHSSSNKIGVFSTSAGSHLGQNSSTLNGGDVINLRPNRQRTKKNRNPFSSCSIP", "length": 237, "header": "tr|A0AAA9SLN0-1|A0AAA9SLN0_BOVIN Isoform 1 of Ras-related protein Rab-23 OS=Bos taurus OX=9913 GN=RAB23 PE=3 SV=2 CANONICAL=A0AAA9SLN0-1" }, "locus": { "chromosome": "23", "start_pos": 3037482, "end_pos": 3019772, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109851.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109851.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083576.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083576.2" } ] } }, { "isoform_ac": "A0AAA9T9M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#A0AAA9T9M3-1", "sequence": { "sequence": "MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRTSVKEDLNVSEVFKYLAEKYLQKLKQQIAENPESMHSSSNKIGTGFIHKDMVAVWTVTSQEEFLCHLSNALLS", "length": 222, "header": "tr|A0AAA9T9M3-1|A0AAA9T9M3_BOVIN Computationally mapped isoform of Ras-related protein Rab-23 OS=Bos taurus OX=9913 GN=RAB23 PE=3 SV=1 CANONICAL=A0AAA9SLN0-1" }, "locus": { "chromosome": "23", "start_pos": 3087621, "end_pos": 3019772, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102924.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102924.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095408.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095408.1" } ] } }, { "isoform_ac": "A0AAA9TG94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#A0AAA9TG94-1", "sequence": { "sequence": "MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRTSVKEDLNVSEVFKYLAEKYLQKLKQQIAENPESMHSSSNKIDPARAPTHARAVVPSCCRVWSPGPTLSPPVC", "length": 222, "header": "tr|A0AAA9TG94-1|A0AAA9TG94_BOVIN Computationally mapped isoform of Ras-related protein Rab-23 OS=Bos taurus OX=9913 GN=RAB23 PE=3 SV=1 CANONICAL=A0AAA9SLN0-1" }, "locus": { "chromosome": "23", "start_pos": 3036142, "end_pos": 3019772, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118134.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118134.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097583.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097583.1" } ] } }, { "isoform_ac": "A0AAA9TGD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0/entry#A0AAA9TGD3-1", "sequence": { "sequence": "MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRTSVKEDLNVSEVFKYLAEKYLQKLKQQIAENPESMHSSSNKIDSDTVLTGVLSSGSGGHVSPARNSAKGPRPLLPCSL", "length": 227, "header": "tr|A0AAA9TGD3-1|A0AAA9TGD3_BOVIN Computationally mapped isoform of Ras-related protein Rab-23 OS=Bos taurus OX=9913 GN=RAB23 PE=3 SV=1 CANONICAL=A0AAA9SLN0-1" }, "locus": { "chromosome": "23", "start_pos": 3047637, "end_pos": 3019772, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120417.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120417.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097240.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:618588", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618588", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "system development", "id": "GO:0048731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "craniofacial suture morphogenesis", "id": "GO:0097094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "cellular defense response", "id": "GO:0006968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "negative regulation of protein import into nucleus", "id": "GO:0042308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042308", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "GTP metabolic process", "id": "GO:0046039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "negative regulation of smoothened signaling pathway", "id": "GO:0045879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "phagocytic vesicle membrane", "id": "GO:0030670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030670", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 205, "end_pos": 207 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SL87-1", "uniprot_ac": "A0AAA9SL87", "uniprot_id": "A0AAA9SL87_BOVIN", "mass": { "chemical_mass": 327483.0, "monoisotopic_mass": 327483.0 }, "refseq": {}, "gene_names": [ { "name": "NBEA", "type": "recommended", "evidence": [ { "id": "A0AAA9SL87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ] } ], "protein_names": [ { "name": "Neurobeachin", "type": "recommended", "evidence": [ { "id": "A0AAA9SL87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#names_and_taxonomy" } ] }, { "name": "Lysosomal-trafficking regulator 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SL87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NBEA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87", "locus": { "chromosome": "12", "start_pos": 25769872, "end_pos": 26441847, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022991", "url": "https://www.ensembl.org/id/ENSBTAG00000022991" } ] } } ], "crossref": [ { "id": "ENSBTAG00000022991", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022991", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525624", "url": "https://www.ncbi.nlm.nih.gov/gene/525624", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06469", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06469", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13385", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13385", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14844", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14844", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20425", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20425", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MIS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0K0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0K0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0K0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S012", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S012", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S012-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S012-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T319", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T319", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T319-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T319-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF64", "url": "https://www.uniprot.org/uniprotkb/F1MF64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF64-1", "url": "https://www.uniprot.org/uniprotkb/F1MF64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEKPGPGPGLEPQPVGLIAVGASGGGGGGGSGGGGSGGSGIGELRGASGSGSVVLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVPDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKDELPNSSTSFLFDKIPKQEEKLLPELSSNHIIPHIQDTQVHLGDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISDRDLASSSKGLEYAEMTATTLETESSGSKIVPNVDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEAPQGVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFAHSFYKETPAAFPDTVKEKEAPTPGEDIHLESSIPHTDSGIGEEQVANILNGAELETSTGPDAMSELLSTLSNEVKKSQESLTENPSEILKSAPSISSISQTKGINVKEILKSLVAAPVEIAECGPEPVPYPDPALKREAQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATAAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDPAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 2945, "header": "tr|A0AAA9SL87-1|A0AAA9SL87_BOVIN Isoform 1 of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=3 SV=1 CANONICAL=A0AAA9SL87-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#A0A3Q1MIS5-1", "sequence": { "sequence": "MASEKPGPGPGLEPQPVGLIAVGASGGGGGGGSGGGGSGGSGIGELRGASGSGSVVLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVPDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKDELPNSSTSFLFDKIPKQEEKLLPELSSNHIIPHIQDTQVHLGDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISDRDLASSSKGLEYAEMTATTLETESSGSKIVPNVDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEAPQGVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFAHSFYKETPAAFPDTVKEKEAPTPGEDIHLESSIPHTDSGIGEEQVANILNGAELETSTGPDAMSELLSTLSNEVKKSQESLTENPSEILKSAPSISSISQTKGINVKEILKSLVAAPVEIAECGPEPVPYPDPALKREAQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATAAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDPAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIKAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 2966, "header": "tr|A0A3Q1MIS5-1|A0A3Q1MIS5_BOVIN Computationally mapped isoform of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=3 SV=2 CANONICAL=A0AAA9SL87-1" }, "locus": { "chromosome": "12", "start_pos": 26441648, "end_pos": 25770876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069105.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069105.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069075.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069075.2" } ] } }, { "isoform_ac": "A0A3Q1N0K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#A0A3Q1N0K0-1", "sequence": { "sequence": "MHFSYCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVPDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKDELPNSSTSFLFDKIPKQEEKLLPELSSNHIIPHIQDTQVHLGDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISDRDLASSSKGLEYAEMTATTLETESSGSKIVPNVDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEAPQGVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFAHSFYKETPAAFPDTVKEKEAPTPGEDIHLESSIPHTDSGIGEEQVANILNGAELETSTGPDAMSELLSTLSNEVKKSQESLTENPSEILKSAPSISSISQTKGINVKEILKSLVAAPVEIAECGPEPVPYPDPALKREAQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATAAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDPAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 2423, "header": "tr|A0A3Q1N0K0-1|A0AAA9SL87_BOVIN Computationally mapped isoform of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=3 SV=2 CANONICAL=A0AAA9SL87-1" }, "locus": { "chromosome": "12", "start_pos": 26273475, "end_pos": 25770876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085729.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085729.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062245.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062245.2" } ] } }, { "isoform_ac": "A0AAA9S012-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#A0AAA9S012-1", "sequence": { "sequence": "MQIQVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 755, "header": "tr|A0AAA9S012-1|A0AAA9SL87_BOVIN Computationally mapped isoform of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=3 SV=1 CANONICAL=A0AAA9SL87-1" }, "locus": { "chromosome": "12", "start_pos": 25976557, "end_pos": 25770876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131156.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131156.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076958.1" } ] } }, { "isoform_ac": "A0AAA9SL87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#A0AAA9SL87-1", "sequence": { "sequence": "MASEKPGPGPGLEPQPVGLIAVGASGGGGGGGSGGGGSGGSGIGELRGASGSGSVVLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVPDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKDELPNSSTSFLFDKIPKQEEKLLPELSSNHIIPHIQDTQVHLGDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISDRDLASSSKGLEYAEMTATTLETESSGSKIVPNVDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEAPQGVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFAHSFYKETPAAFPDTVKEKEAPTPGEDIHLESSIPHTDSGIGEEQVANILNGAELETSTGPDAMSELLSTLSNEVKKSQESLTENPSEILKSAPSISSISQTKGINVKEILKSLVAAPVEIAECGPEPVPYPDPALKREAQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATAAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDPAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 2945, "header": "tr|A0AAA9SL87-1|A0AAA9SL87_BOVIN Isoform 1 of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=3 SV=1 CANONICAL=A0AAA9SL87-1" }, "locus": { "chromosome": "12", "start_pos": 26441648, "end_pos": 25770876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101235.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101235.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083405.1" } ] } }, { "isoform_ac": "A0AAA9T319-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#A0AAA9T319-1", "sequence": { "sequence": "MASEKPGPGPGLEPQPVGLIAVGASGGGGGGGSGGGGSGGSGIGELRGASGSGSVVLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIAGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDPAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 1021, "header": "tr|A0AAA9T319-1|A0AAA9T319_BOVIN Computationally mapped isoform of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=4 SV=1 CANONICAL=A0AAA9SL87-1" }, "locus": { "chromosome": "12", "start_pos": 26441648, "end_pos": 25770876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098633.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098633.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091012.1" } ] } }, { "isoform_ac": "F1MF64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87/entry#F1MF64-1", "sequence": { "sequence": "MASEKPGPGPGLEPQPVGLIAVGASGGGGGGGSGGGGSGGSGIGELRGASGSGSVVLPAGMINPSVPIRNIRMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVLNQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVPDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKDELPNSSTSFLFDKIPKQEEKLLPELSSNHIIPHIQDTQVHLGDDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISDRDLASSSKGLEYAEMTATTLETESSGSKIVPNVDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQEAPQGVTATAASKTPLENVPGNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETARTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIPEQSFAHSFYKETPAAFPDTVKEKEAPTPGEDIHLESSIPHTDSGIGEEQVANILNGAELETSTGPDAMSELLSTLSNEVKKSQESLTENPSEILKSAPSISSISQTKGINVKEILKSLVAAPVEIAECGPEPVPYPDPALKREAQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATAAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDPAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPNRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAKKPEDFVRINRMALESEFVSCQLHQWIDLVFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVSSEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY", "length": 2942, "header": "tr|F1MF64-1|A0AAA9SL87_BOVIN Computationally mapped isoform of Neurobeachin OS=Bos taurus OX=9913 GN=NBEA PE=3 SV=4 CANONICAL=A0AAA9SL87-1" }, "locus": { "chromosome": "12", "start_pos": 26441648, "end_pos": 25770876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061623.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061623.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053802.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053802.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1658, "start_aa": "Thr", "end_pos": 1658, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1658", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" }, { "name": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0098696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098696", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SL87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1142, "end_pos": 1144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1451, "end_pos": 1453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1460, "end_pos": 1462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1494, "end_pos": 1496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1526, "end_pos": 1528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1837, "end_pos": 1839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1880, "end_pos": 1882, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2232, "end_pos": 2234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2283, "end_pos": 2285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2410, "end_pos": 2412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2658, "end_pos": 2660, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2764, "end_pos": 2766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2847, "end_pos": 2849, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2861, "end_pos": 2863, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 855, "end_pos": 857, "annotation": "n_glycosylation_sequon" }, { "start_pos": 981, "end_pos": 983, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SL87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" }, { "id": "PS50197", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50197" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BEACH", "eco_id": "ECO_0000259", "start_pos": 2273, "end_pos": 2562, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SL87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL87" }, { "id": "PS51783", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51783" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BEACH-type PH", "eco_id": "ECO_0000259", "start_pos": 2146, "end_pos": 2254, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1658 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1142, "end_pos": 1144 }, { "start_pos": 1451, "end_pos": 1453 }, { "start_pos": 1460, "end_pos": 1462 }, { "start_pos": 1494, "end_pos": 1496 }, { "start_pos": 1526, "end_pos": 1528 }, { "start_pos": 1837, "end_pos": 1839 }, { "start_pos": 1880, "end_pos": 1882 }, { "start_pos": 2232, "end_pos": 2234 }, { "start_pos": 2283, "end_pos": 2285 }, { "start_pos": 2410, "end_pos": 2412 }, { "start_pos": 2658, "end_pos": 2660 }, { "start_pos": 2764, "end_pos": 2766 }, { "start_pos": 2847, "end_pos": 2849 }, { "start_pos": 2861, "end_pos": 2863 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 855, "end_pos": 857 }, { "start_pos": 981, "end_pos": 983 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMD5-1", "uniprot_ac": "A0AAA9SMD5", "uniprot_id": "A0AAA9SMD5_BOVIN", "mass": { "chemical_mass": 195017.0, "monoisotopic_mass": 195017.0 }, "refseq": {}, "gene_names": [ { "name": "MYO5B", "type": "recommended", "evidence": [ { "id": "A0AAA9SMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ] } ], "protein_names": [ { "name": "Unconventional myosin-Vb", "type": "recommended", "evidence": [ { "id": "A0AAA9SMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.", "evidence": [ { "database": "UniProtKB", "id": "F1MMQ6", "url": "https://www.uniprot.org/uniprotkb/F1MMQ6#function" }, { "database": "UniProtKB", "id": "ARBA00058661", "url": "https://www.uniprot.org/uniprotkb/ARBA00058661#function" }, { "database": "UniProtKB", "id": "A0AAA9SFS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS4#function" }, { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5#function" }, { "database": "UniProtKB", "id": "A0AAA9T280", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T280#function" }, { "database": "UniProtKB", "id": "A0A3Q1MKF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKF2#function" }, { "database": "UniProtKB", "id": "A0AAA9TTE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE6#function" }, { "database": "UniProtKB", "id": "A0AAA9U1G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1G5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYO5B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5", "locus": { "chromosome": "24", "start_pos": 49489277, "end_pos": 49825965, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019455", "url": "https://www.ensembl.org/id/ENSBTAG00000019455" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019455", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019455", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15477", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15477", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514078", "url": "https://www.ncbi.nlm.nih.gov/gene/514078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MKF2", "url": "https://www.orthodb.org/?gene=A0A3Q1MKF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMQ6", "url": "https://www.orthodb.org/?gene=F1MMQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140:SF356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140:SF356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16027:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16027:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01843", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01843", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432040", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432040", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MKF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T280", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T280", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T280-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T280-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMQ6", "url": "https://www.uniprot.org/uniprotkb/F1MMQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMQ6-1", "url": "https://www.uniprot.org/uniprotkb/F1MMQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPYGTFSRKPWLWIRDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1684, "header": "tr|A0AAA9SMD5-1|A0AAA9SMD5_BOVIN Isoform 1 of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MKF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0A3Q1MKF2-1", "sequence": { "sequence": "MSVSELYSQYTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETIQEYPIDVQNNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYDQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1846, "header": "tr|A0A3Q1MKF2-1|A0A3Q1MKF2_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=2 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49824636, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084252.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084252.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071343.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071343.2" } ] } }, { "isoform_ac": "A0AAA9SBW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0AAA9SBW8-1", "sequence": { "sequence": "METLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1181, "header": "tr|A0AAA9SBW8-1|A0AAA9SMD5_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49568445, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124439.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124439.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083588.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083588.1" } ] } }, { "isoform_ac": "A0AAA9SFS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0AAA9SFS4-1", "sequence": { "sequence": "MRNLDSILKRRDITLPTKIQEYPIDVQNNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYDQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1792, "header": "tr|A0AAA9SFS4-1|A0AAA9SMD5_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49677184, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125841.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125841.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082725.1" } ] } }, { "isoform_ac": "A0AAA9SMD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0AAA9SMD5-1", "sequence": { "sequence": "MEPYGTFSRKPWLWIRDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1684, "header": "tr|A0AAA9SMD5-1|A0AAA9SMD5_BOVIN Isoform 1 of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49645801, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091853.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091853.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085098.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085098.1" } ] } }, { "isoform_ac": "A0AAA9T280-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0AAA9T280-1", "sequence": { "sequence": "MKPDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1671, "header": "tr|A0AAA9T280-1|A0AAA9T280_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49687955, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120335.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120335.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092903.1" } ] } }, { "isoform_ac": "A0AAA9TTE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0AAA9TTE6-1", "sequence": { "sequence": "MDALAENCFQKSSLIQYTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETIQEYPIDVQNNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYDQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1827, "header": "tr|A0AAA9TTE6-1|A0AAA9TTE6_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49825766, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099860.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099860.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101627.1" } ] } }, { "isoform_ac": "A0AAA9U1G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#A0AAA9U1G5-1", "sequence": { "sequence": "MGRTACFILGKEDWEPAGVPNYTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETIQEYPIDVQNNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYDQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1832, "header": "tr|A0AAA9U1G5-1|A0AAA9U1G5_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=1 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49698622, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134716.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134716.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103633.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103633.1" } ] } }, { "isoform_ac": "F1MMQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5/entry#F1MMQ6-1", "sequence": { "sequence": "MLGCSRDEKNQSIIVSGESGAGKTVSAKYAMRYFTTVSGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYRIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAEDFFYTSQGGNTVIEGVDDAEDFEKTRQAFTLVGVRESHQISIFKIIASILHLGNVEIQAERDGESCRVSPEDEHLSDFCRLLGVELSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFHWIVEHVNKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWTQKLYDRHSGSQHFQKPRMSNKAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDGKDSAPTATASSKINIRSSRPPVKASNKEHKKTVGYQFRSSLHLLMETLNATTPHYVRCIKPNDEKLPFHFNPKRAVQQLRACGVLETIRISAAGYPSRWSYHDFFNRYRVLVKKRDLANSDKKAICRSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRAATIMIQKAVRGWLQKVKYRRLKGATLILQRYCRGYLARRLAKHLRRTRAAVVLQKQYRMQRARRAYQRVRRAAVVIQAFARGMFVRRIYHQVLREHKATIIQKHVRGWMARRRFQRLRGAAVVIQCGFRRLKAKQALKALRIEARSAEHLKRLNVGMENKIVQLQRKIDDQNKELKTLSEQLSAITSTHTMEVEKLKKEVACYQQSQGEDRGPQLQEEVESLRTELQRAHSERKVLEDTHTREKDELRKRVADLEQENALLKNEKEQLNNQILCQSKDEFAQNSVKENLMMKKELEEERSRYQNLVKEYSRLEQRYDNLRDEMTILKQTPGHRRNPSNQSSLESDSNYPSISTSEVGDTEDTLQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKKEQQDGKRVPADQPSNDSDLDQDADLAYNSLKRQELESENKKLKNELNELRKAVADQASEHSPAAAGTPDSYSLLLNQLRVANEELEVRKEEVLILRTQIVSADQRRLAGKGSEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNRLLEAQLQAQSREHEEEVDNLKAQLEALKEEMDRQQQTFCQTLLLSPEAQVEFGIQQEMSRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKVQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTELKPQVLAGAVPCLPAYILYMCLRHADYVNDDLKVHSLLTSTINGIKKVLKKHNEDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGLLQPMIVSAMLENESIQGLSGVKPTGYRKRTSSMPEGDNSYCLEAIIRQMNSFHTVMCDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVETMEPLIQAAQLLQLKKKSPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQDRNDPQQLLLDFKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV", "length": 1674, "header": "tr|F1MMQ6-1|F1MMQ6_BOVIN Computationally mapped isoform of Unconventional myosin-Vb OS=Bos taurus OX=9913 GN=MYO5B PE=3 SV=4 CANONICAL=A0AAA9SMD5-1" }, "locus": { "chromosome": "24", "start_pos": 49647262, "end_pos": 49490281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061584.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061584.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053198.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053198.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514078", "resource": "KEGG Pathway" }, { "id": "R-BTA-432040", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432040", "resource": "Reactome", "description": "Vasopressin regulates renal water homeostasis via Aquaporins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "apical cortex", "id": "GO:0045179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1046, "end_pos": 1048, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1460, "end_pos": 1462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1551, "end_pos": 1553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 964, "end_pos": 966, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" }, { "id": "PS51126", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51126" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dilute", "eco_id": "ECO_0000259", "start_pos": 1362, "end_pos": 1639, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMD5" }, { "id": "PS51456", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51456" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin motor", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 621, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1046, "end_pos": 1048 }, { "start_pos": 1460, "end_pos": 1462 }, { "start_pos": 1551, "end_pos": 1553 }, { "start_pos": 20, "end_pos": 22 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 508, "end_pos": 510 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 964, "end_pos": 966 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKM0-1", "uniprot_ac": "A0AAA9SKM0", "uniprot_id": "A0AAA9SKM0_BOVIN", "mass": { "chemical_mass": 83578.0, "monoisotopic_mass": 83578.0 }, "refseq": {}, "gene_names": [ { "name": "ADARB1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ] } ], "protein_names": [ { "name": "Adenosine deaminase RNA specific B1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADARB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0", "locus": { "chromosome": "1", "start_pos": 145051007, "end_pos": 144937740, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017486", "url": "https://www.ensembl.org/id/ENSBTAG00000017486" } ] } } ], "crossref": [ { "id": "A0AAA9SKM0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017486", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017486", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19895", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19895", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19898", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19898", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521761", "url": "https://www.ncbi.nlm.nih.gov/gene/521761", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IFSPHES", "url": "https://omabrowser.org/oma/group/IFSPHES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIG3", "url": "https://www.orthodb.org/?gene=A0A3Q1MIG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10910", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10910", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10910:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10910:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02137", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02137", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MIG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T892", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T892", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T892-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T892-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKAFRLAWRAGQGPEGRQGPEGSSPSRRHARIISAPPALQGPGGTGTRGSHDRNSLRQSRNPQKYFAMDIEDEENMSSSSTDVKENCNLDGAPPKDSSAPGPGEGAPLSNGGGGGTSRKRALDEGSNGHAKFRLKKRRRAPGPALPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFLMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRSLSTNADFTSDQADFPDALFNGFETPDRSEVPFYLGSNGDDSFSSSGDLSLAASPVPAGLAQPPLPGPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKNFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVARLVLDKFGDLTDSFASPHARRKVLAGIVMTTGTDVKDAKVISISTGTKCINGEYMSDRGLALNDCHAEIIARRSLLRFLYTQLEIYLNSKDDQKRSIFEKSERGGFKLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASVQTWDGVLQGERLLTMSCSDKMARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSALEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSSLLRSKITKPNVYHESKLVAKEYQAAKACLFRAFIKAGLGAWVEKPTEQDQFSLTP", "length": 769, "header": "tr|A0AAA9SKM0-1|A0AAA9SKM0_BOVIN Isoform 1 of Adenosine deaminase RNA specific B1 OS=Bos taurus OX=9913 GN=ADARB1 PE=4 SV=1 CANONICAL=A0AAA9SKM0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0/entry#A0A3Q1MIG3-1", "sequence": { "sequence": "MDIEDEENMIGLGVCCGRFPYSGSSSTDVKENCNLDGAPPKDSSAPGPGEGAPLSNGGGGGTSRKRALDEGSNGHAKFRLKKRRRAPGPALPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFLMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRSLSTNADFTSDQADFPDALFNGFETPDRSEVPFYLGSNGDDSFSSSGDLSLAASPVPAGLAQPPLPGPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKNFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVARLVLDKFGDLTDSFASPHARRKVLAGIVMTTGTDVKDAKVISISTGTKCINGEYMSDRGLALNDCHAEIIARRSLLRFLYTQLEIYLNSKDDQKRSIFEKSERGGFKLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASVQTWDGVLQGERLLTMSCSDKMARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSALEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSSLLRSKITKPNVYHESKLVAKEYQAAKACLFRAFIKAGLGAWVEKPTEQDQFSLTP", "length": 714, "header": "tr|A0A3Q1MIG3-1|A0AAA9SKM0_BOVIN Computationally mapped isoform of Adenosine deaminase RNA specific B1 OS=Bos taurus OX=9913 GN=ADARB1 PE=4 SV=1 CANONICAL=A0AAA9SKM0-1" }, "locus": { "chromosome": "1", "start_pos": 145050003, "end_pos": 145012322, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084373.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084373.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068958.1" } ] } }, { "isoform_ac": "A0AAA9SKM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0/entry#A0AAA9SKM0-1", "sequence": { "sequence": "MGKAFRLAWRAGQGPEGRQGPEGSSPSRRHARIISAPPALQGPGGTGTRGSHDRNSLRQSRNPQKYFAMDIEDEENMSSSSTDVKENCNLDGAPPKDSSAPGPGEGAPLSNGGGGGTSRKRALDEGSNGHAKFRLKKRRRAPGPALPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFLMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRSLSTNADFTSDQADFPDALFNGFETPDRSEVPFYLGSNGDDSFSSSGDLSLAASPVPAGLAQPPLPGPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKNFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVARLVLDKFGDLTDSFASPHARRKVLAGIVMTTGTDVKDAKVISISTGTKCINGEYMSDRGLALNDCHAEIIARRSLLRFLYTQLEIYLNSKDDQKRSIFEKSERGGFKLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASVQTWDGVLQGERLLTMSCSDKMARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSALEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSSLLRSKITKPNVYHESKLVAKEYQAAKACLFRAFIKAGLGAWVEKPTEQDQFSLTP", "length": 769, "header": "tr|A0AAA9SKM0-1|A0AAA9SKM0_BOVIN Isoform 1 of Adenosine deaminase RNA specific B1 OS=Bos taurus OX=9913 GN=ADARB1 PE=4 SV=1 CANONICAL=A0AAA9SKM0-1" }, "locus": { "chromosome": "1", "start_pos": 145050003, "end_pos": 144978222, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102649.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102649.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084426.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084426.1" } ] } }, { "isoform_ac": "A0AAA9T892-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0/entry#A0AAA9T892-1", "sequence": { "sequence": "MHLEYRNSLRQSRNPQKYFAMDIEDEENMSSSSTDVKENCNLDGAPPKDSSAPGPGEGAPLSNGGGGGTSRKRALDEGSNGHAKFRLKKRRRAPGPALPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFLMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRSLSTNADFTSDQADFPDALFNGFETPDRSEVPFYLGSNGDDSFSSSGDLSLAASPVPAGLAQPPLPGPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKNFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVARLVLDKFGDLTDSFASPHARRKVLAGIVMTTGTDVKDAKVISISTGTKCINGEYMSDRGLALNDCHAEIIARRSLLRFLYTQLEIYLNSKDDQKRSIFEKSERGGFKLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASVQTWDGVLQGERLLTMSCSDKMARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSALEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSSLLRSKITKPNVYHESKLVAKEYQAAKACLFRAFIKAGLGAWVEKPTEQDQFSLTP", "length": 721, "header": "tr|A0AAA9T892-1|A0AAA9T892_BOVIN Computationally mapped isoform of Adenosine deaminase RNA specific B1 OS=Bos taurus OX=9913 GN=ADARB1 PE=4 SV=1 CANONICAL=A0AAA9SKM0-1" }, "locus": { "chromosome": "1", "start_pos": 145050003, "end_pos": 145005835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104231.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104231.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093031.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093031.1" } ] } }, { "isoform_ac": "A0AAA9TNS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0/entry#A0AAA9TNS4-1", "sequence": { "sequence": "SLITGTQAMGTVLSIRGRRCKRRRRRRSERKDRNSLRQSRNPQKYFAMDIEDEENMSSSSTDVKENCNLDGAPPKDSSAPGPGEGAPLSNGGGGGTSRKRALDEGSNGHAKFRLKKRRRAPGPALPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFLMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRSLSTNADFTSDQADFPDALFNGFETPDRSEVPFYLGSNGDDSFSSSGDLSLAASPVPAGLAQPPLPGPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKNFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVARLVLDKFGDLTDSFASPHARRKVLAGIVMTTGTDVKDAKVISISTGTKCINGEYMSDRGLALNDCHAEIIARRSLLRFLYTQLEIYLNSKDDQKRSIFEKSERGGFKLKENVQFHLYISTSPCGDARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASVQTWDGVLQGERLLTMSCSDKMARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSALEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSSLLRSKITKPNVYHESKLVAKEYQAAKACLFRAFIKAGLGAWVEKPTEQDQFSLTP", "length": 748, "header": "tr|A0AAA9TNS4-1|A0AAA9TNS4_BOVIN Computationally mapped isoform of Adenosine deaminase RNA specific B1 OS=Bos taurus OX=9913 GN=ADARB1 PE=4 SV=1 CANONICAL=A0AAA9SKM0-1" }, "locus": { "chromosome": "1", "start_pos": 145050003, "end_pos": 145000504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134396.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134396.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097990.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097990.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7H913-1", "protein_name": "Double-stranded RNA-specific editase 1 isoform X1", "gene_name": "Adarb1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MILVSEDWNTTGASSSSTDVKENRNLDNMPPKDSSTPGPVEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQIFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPETHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEIINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLTP", "length": 715 }, "evidence": [ { "id": "A0AAA9SKM0", "url": "https://omabrowser.org/oma/group/A0AAA9SKM0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P51400-1", "protein_name": "Double-stranded RNA-specific editase 1", "gene_name": "Adarb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDIEDEENMSSSSIDVKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP", "length": 711 }, "evidence": [ { "id": "A0AAA9SKM0", "url": "https://omabrowser.org/oma/group/A0AAA9SKM0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P78563-1", "protein_name": "Double-stranded RNA-specific editase 1", "gene_name": "ADARB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLTP", "length": 741 }, "evidence": [ { "id": "A0AAA9SKM0", "url": "https://omabrowser.org/oma/group/A0AAA9SKM0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91ZS8-1", "protein_name": "Double-stranded RNA-specific editase 1", "gene_name": "Adarb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDIEDEENMSSSSTDIKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDATIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP", "length": 711 }, "evidence": [ { "id": "A0AAA9SKM0", "url": "https://omabrowser.org/oma/group/A0AAA9SKM0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NII1-1", "protein_name": "Double-stranded RNA-specific editase Adar", "gene_name": "Adar", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLNSANNNSPQHPVSAPSDINMNGYNRKLPQKRGYEMPKYSDPKKKMCKERIPQPKNTVAMLNELRHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRSKKVARIEAAATALRSFIQFKDGAVLSPLKPAGNLDFTSDEHLENGIENLSSSKMFEIIQTMLTEKLSNPTSLEQPTFCMSQNVSKSAITVDGQKKVPDKGPVMLLYELFNDVNFECINIDGAQNNCRFKMTVTINEKKFDGTGPSKKTAKNAAAKAALASLCNISYSPMVVPQKNVPLPIDDKSSSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVDKHPNRKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLNKPRLALVTSAEPRNQAKAPNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKYGFLMANLPGILVRKVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE", "length": 669 }, "evidence": [ { "id": "A0AAA9SKM0", "url": "https://omabrowser.org/oma/group/A0AAA9SKM0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "adenosine deaminase activity", "id": "GO:0004000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "double-stranded RNA adenosine deaminase activity", "id": "GO:0003726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "mRNA modification", "id": "GO:0016556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "positive regulation of viral genome replication", "id": "GO:0045070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" }, { "name": "adenosine to inosine editing", "id": "GO:0006382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006382", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 564, "end_pos": 566, "annotation": "n_glycosylation_sequon" }, { "start_pos": 665, "end_pos": 667, "annotation": "n_glycosylation_sequon" }, { "start_pos": 669, "end_pos": 671, "annotation": "n_glycosylation_sequon" }, { "start_pos": 681, "end_pos": 683, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" }, { "id": "PS50141", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50141" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "A to I editase", "eco_id": "ECO_0000259", "start_pos": 438, "end_pos": 765, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SKM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKM0" }, { "id": "PS50137", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50137" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DRBM", "eco_id": "ECO_0000259", "start_pos": 146, "end_pos": 212, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 564, "end_pos": 566 }, { "start_pos": 665, "end_pos": 667 }, { "start_pos": 669, "end_pos": 671 }, { "start_pos": 681, "end_pos": 683 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJK5-1", "uniprot_ac": "A0AAA9SJK5", "uniprot_id": "A0AAA9SJK5_BOVIN", "mass": { "chemical_mass": 45870.0, "monoisotopic_mass": 45870.0 }, "refseq": { "ac": "XP_024836467", "name": "double C2-like domain-containing protein beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836467" }, "gene_names": [ { "name": "DOC2B", "type": "recommended", "evidence": [ { "id": "A0AAA9SJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ] }, { "name": "DOC2B", "type": "synonym", "evidence": [ { "id": "XP_024836467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836467" } ] } ], "protein_names": [ { "name": "Double C2-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5/entry#names_and_taxonomy" } ] }, { "name": "double C2-like domain-containing protein beta", "type": "synonym", "evidence": [ { "id": "XP_024836467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836467" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DOC2B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5", "locus": { "chromosome": "19", "start_pos": 22495826, "end_pos": 22471836, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025140", "url": "https://www.ensembl.org/id/ENSBTAG00000025140" } ] } } ], "crossref": [ { "id": "A0AAA9SJK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025140", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025140", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04035", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04035", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08384", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08384", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785428", "url": "https://www.ncbi.nlm.nih.gov/gene/785428", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785428", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785428", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DKKMERW", "url": "https://omabrowser.org/oma/group/DKKMERW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0W4", "url": "https://www.orthodb.org/?gene=F1N0W4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45729", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45729", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45729:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45729:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836467", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836467", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0W4", "url": "https://www.uniprot.org/uniprotkb/F1N0W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0W4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAAASAGRRSPSDGARDDDEDVDQLFGAYGSSPGPGPAPSPGRPPAKPPEEELDADGYESDDCTALGTLDFSLLYDQENNALHCTIAKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILVSLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEITVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNELPGAVLSD", "length": 412, "header": "tr|A0AAA9SJK5-1|A0AAA9SJK5_BOVIN Isoform 1 of Double C2-like domain-containing protein OS=Bos taurus OX=9913 GN=DOC2B PE=4 SV=1 CANONICAL=A0AAA9SJK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5/entry#A0AAA9SJK5-1", "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAAASAGRRSPSDGARDDDEDVDQLFGAYGSSPGPGPAPSPGRPPAKPPEEELDADGYESDDCTALGTLDFSLLYDQENNALHCTIAKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILVSLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEITVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNELPGAVLSD", "length": 412, "header": "tr|A0AAA9SJK5-1|A0AAA9SJK5_BOVIN Isoform 1 of Double C2-like domain-containing protein OS=Bos taurus OX=9913 GN=DOC2B PE=4 SV=1 CANONICAL=A0AAA9SJK5-1" }, "locus": { "chromosome": "19", "start_pos": 22494822, "end_pos": 22472035, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123623.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123623.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082786.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082786.1" } ] } }, { "isoform_ac": "F1N0W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5/entry#F1N0W4-1", "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAAASAGRRSPSDGARDDDEDVDQLFGAYGSSPGPGPAPSPGRPPAKPPEEELDADGYESDDCTALGTLDFSLLYDQENNALHCTIAKAKVPRLMFSRKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILVSLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEITVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNELPGAVLSD", "length": 421, "header": "tr|F1N0W4-1|F1N0W4_BOVIN Computationally mapped isoform of Double C2 domain beta OS=Bos taurus OX=9913 GN=DOC2B PE=4 SV=4 CANONICAL=A0AAA9SJK5-1" }, "locus": { "chromosome": "19", "start_pos": 22494822, "end_pos": 22472035, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035180.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035180.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035058.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035058.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785428", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785428", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BHY3-1", "protein_name": "Double C2-like domain-containing protein", "gene_name": "DOC2B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGLRAAAPPDAPARPAAASAGRRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKSEDKSLEERGRILVSLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEITVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNELPGAVLSD", "length": 412 }, "evidence": [ { "id": "A0AAA9SJK5", "url": "https://omabrowser.org/oma/group/A0AAA9SJK5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P70169-1", "protein_name": "Double C2-like domain-containing protein beta", "gene_name": "Doc2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRAPAPPDAPARSPAASASPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPARPPAKPPEDEPDVDGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMVRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNELPGAVLSD", "length": 412 }, "evidence": [ { "id": "A0AAA9SJK5", "url": "https://omabrowser.org/oma/group/A0AAA9SJK5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P70610-1", "protein_name": "Double C2-like domain-containing protein beta", "gene_name": "Doc2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAPARSPAATAGPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPVRPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNEIPGAVLSD", "length": 412 }, "evidence": [ { "id": "A0AAA9SJK5", "url": "https://omabrowser.org/oma/group/A0AAA9SJK5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14184-1", "protein_name": "Double C2-like domain-containing protein beta", "gene_name": "DOC2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD", "length": 412 }, "evidence": [ { "id": "A0AAA9SJK5", "url": "https://omabrowser.org/oma/group/A0AAA9SJK5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "positive regulation of calcium ion-dependent exocytosis", "id": "GO:0045956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045956", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "calcium ion-regulated exocytosis of neurotransmitter", "id": "GO:0048791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048791", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" }, { "name": "calcium-dependent activation of synaptic vesicle fusion", "id": "GO:0099502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099502", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJK5" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 126, "end_pos": 250, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 241, "end_pos": 243 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLA8-1", "uniprot_ac": "A0AAA9SLA8", "uniprot_id": "A0AAA9SLA8_BOVIN", "mass": { "chemical_mass": 95090.0, "monoisotopic_mass": 95090.0 }, "refseq": {}, "gene_names": [ { "name": "JADE2", "type": "recommended", "evidence": [ { "id": "A0AAA9SLA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ] } ], "protein_names": [ { "name": "Jade family PHD finger 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SLA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JADE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8", "locus": { "chromosome": "7", "start_pos": 46116902, "end_pos": 46069059, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021687", "url": "https://www.ensembl.org/id/ENSBTAG00000021687" } ] } } ], "crossref": [ { "id": "A0AAA9SLA8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021687", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021687", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15680", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15680", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512319", "url": "https://www.ncbi.nlm.nih.gov/gene/512319", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512319", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512319", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SMASCIT", "url": "https://omabrowser.org/oma/group/SMASCIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MI33", "url": "https://www.orthodb.org/?gene=A0A3Q1MI33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N724", "url": "https://www.orthodb.org/?gene=A0A3Q1N724", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793:SF84", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793:SF84", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10513", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10513", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214847", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MI33", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI33-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N724", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N724", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N724-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N724-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SND0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SND0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHSTGEIAHVGQSCFKEYIAGRLRGAHATTTFGRMEEKRRKYSISSDNSDTTDSHATSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPTQVSPSGSELGEGSQPDWAGGSRYDLDEIDAYWLELINSELKEMEKPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHSLEMRTILADNDEVKFKSFCQEHSDGGPRGEAPSEPVEPSPASEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANSNQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRKTKGKKSDSKRKGREGPKGSPEKKEKVKAGSDSVLGQLGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWSLNNGHREDPAPGLLSEELLQDEETLLSFMREPSLRPGDPARKARGRTRLPAKKKPPQDGPGSRTTPDKPPKKPWGQDTGSSKGGQGPPARKPPRRTPSHLPSSPTAGDCPIPAAPESPPPLAPETPEEAAPVAADSNVQVPGPTASPKPLGRLRLPRESKGTRRSPGARPDAGTGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDSGVQPGPREAGAEEVVRMGVLAS", "length": 861, "header": "tr|A0AAA9SLA8-1|A0AAA9SLA8_BOVIN Isoform 1 of Jade family PHD finger 2 OS=Bos taurus OX=9913 GN=JADE2 PE=3 SV=1 CANONICAL=A0AAA9SLA8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MI33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8/entry#A0A3Q1MI33-1", "sequence": { "sequence": "MEEKRRKYSISSDNSDTTDSHATSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPTQVSPSGSELGEGSQPDWAGGSRYDLDEIDAYWLELINSELKEMEKPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHSLEMRTILADNDEVKFKSFCQEHSDGGPRGEAPSEPVEPSPASEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANSNQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRKTKGKKSDSKRKGREGPKGSPEKKEKVKAGSDSVLGQLGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWSLNNGHREDPAPGLLSEELLQDEETLLSFMREPSLRPGDPARKARGRTRLPAKKKPPQDGPGSRTTPDKPPKKPWGQDTGSSKGGQGPPARKPPRRTPSHLPSSPTAGDCPIPAAPESPPPLAPETPEEAAPVAADSNVQVPGPTASPKPLGRLRLPRESKGTRRSPGARPDAGTGPPSAVAERPKIFFLPRASGHLRSQLCLCWIAWSDLTGSKGTSFKEQPNSAGRWGAQVW", "length": 825, "header": "tr|A0A3Q1MI33-1|A0AAA9SLA8_BOVIN Computationally mapped isoform of Jade family PHD finger 2 OS=Bos taurus OX=9913 GN=JADE2 PE=3 SV=3 CANONICAL=A0AAA9SLA8-1" }, "locus": { "chromosome": "7", "start_pos": 46116688, "end_pos": 46077811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086455.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086455.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073944.3", "url": "https://www.ensembl.org/id/ENSBTAP00000073944.3" } ] } }, { "isoform_ac": "A0A3Q1N724-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8/entry#A0A3Q1N724-1", "sequence": { "sequence": "MEEKRRKYSISSDNSDTTDSHATSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPTQVSPSGSELGEGSQPDWAGGSRYDLDEIDAYWLELINSELKEMEKPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHSLEMRTILADNDEVKFKSFCQEHSDGGPRGEAPSEPVEPSPASEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANSNQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERSGLGGKQRARRATQKEKAARAPRAAPRRKRK", "length": 507, "header": "tr|A0A3Q1N724-1|A0AAA9SLA8_BOVIN Computationally mapped isoform of Jade family PHD finger 2 OS=Bos taurus OX=9913 GN=JADE2 PE=3 SV=2 CANONICAL=A0AAA9SLA8-1" }, "locus": { "chromosome": "7", "start_pos": 46112431, "end_pos": 46077811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084531.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084531.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066394.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066394.2" } ] } }, { "isoform_ac": "A0AAA9SLA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8/entry#A0AAA9SLA8-1", "sequence": { "sequence": "MHSTGEIAHVGQSCFKEYIAGRLRGAHATTTFGRMEEKRRKYSISSDNSDTTDSHATSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPTQVSPSGSELGEGSQPDWAGGSRYDLDEIDAYWLELINSELKEMEKPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHSLEMRTILADNDEVKFKSFCQEHSDGGPRGEAPSEPVEPSPASEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANSNQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRERSGRKTKGKKSDSKRKGREGPKGSPEKKEKVKAGSDSVLGQLGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWSLNNGHREDPAPGLLSEELLQDEETLLSFMREPSLRPGDPARKARGRTRLPAKKKPPQDGPGSRTTPDKPPKKPWGQDTGSSKGGQGPPARKPPRRTPSHLPSSPTAGDCPIPAAPESPPPLAPETPEEAAPVAADSNVQVPGPTASPKPLGRLRLPRESKGTRRSPGARPDAGTGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDSGVQPGPREAGAEEVVRMGVLAS", "length": 861, "header": "tr|A0AAA9SLA8-1|A0AAA9SLA8_BOVIN Isoform 1 of Jade family PHD finger 2 OS=Bos taurus OX=9913 GN=JADE2 PE=3 SV=1 CANONICAL=A0AAA9SLA8-1" }, "locus": { "chromosome": "7", "start_pos": 46114535, "end_pos": 46069258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099267.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099267.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083425.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083425.1" } ] } }, { "isoform_ac": "A0AAA9SND0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8/entry#A0AAA9SND0-1", "sequence": { "sequence": "MEEKRRKYSISSDNSDTTDSHATSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPTQVSPSGSELGEGSQPDWAGGSRYDLDEIDAYWLELINSELKEMEKPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHSLEMRTILADNDEVKFKSFCQEHSDGGPRGEAPSEPVEPSPASEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANSNQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWSLNNGHREDPAPGLLSEELLQDEETLLSFMREPSLRPGDPARKARGRTRLPAKKKPPQDGPGSRTTPDKPPKKPWGQDTGSSKGGQGPPARKPPRRTPSHLPSSPTAGDCPIPAAPESPPPLAPETPEEAAPVAADSNVQVPGPTASPKPLGRLRLPRESKGTRRSPGARPDAGTGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDSGVQPGPREAGAEEVVRMGVLAS", "length": 784, "header": "tr|A0AAA9SND0-1|A0AAA9SND0_BOVIN Computationally mapped isoform of Jade family PHD finger 2 OS=Bos taurus OX=9913 GN=JADE2 PE=3 SV=1 CANONICAL=A0AAA9SLA8-1" }, "locus": { "chromosome": "7", "start_pos": 46114535, "end_pos": 46077811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129441.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129441.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086849.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086849.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 731, "start_aa": "Thr", "end_pos": 731, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr731", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 770, "start_aa": "Thr", "end_pos": 770, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr770", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512319", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512319", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214847", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "resource": "Reactome", "description": "HATs acetylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YJE4-1", "protein_name": "Jade family PHD finger 2", "gene_name": "JADE2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLVPSPVLKCARRERRGCKHELFQMEEKRRKYSISSDNSDTTDSHTTSTSRCSKIPSTKSSWSRQKEKKPSEVFRTDLITAMKIPDSFQLSPEEYYVLADPWRQEWEKGVQVPASAEAIPEPVVRIIPQLENLPSPVSPSSLQGSEISEATRTYLQGMSRYDLDELDACWLELVNMELKEMEKPELDEITLERVLEELETMCYENMNIAIETEEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPIGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPACVTAFHVTCAFDHNLDMRTILADNDEVKFKSFCLEHSTGATKLPEEARTEPDQAQLDLEKVTLRKQKLQQLEEDFYELVKPSEVAENLDLSESLVDFVYQYWKLKRKANSNKPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRREKMKHTICKLQEQIFHLQMILIEKDLYPEQTGKKTKGKKSDPRRKGRDGRKNSPEKKEKRKSVNETVLGQLGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWSLNNAHHEDSTPGLSEELLQDEETLLSFMMDHSLRSPFKQSEAAKKVKSKTRTNTKKKPPRSGLTAVFRSQQEGSERWTNHGSDLSDDAAKPCAQESRPGRSEKGAARPADRRGSGEAKRAARRGPGPKGNDPPAPRGCAGEEEAVVAANGARPEPNPAAQVPDPVGSPKTVVRFKLPKESRGTRRSQPPKTDGPGGPPLRRFEAETDGYFSDAEMSDSDGEPRGGRAQRGQLEPGGEEIVRMSILAS", "length": 864 }, "evidence": [ { "id": "A0AAA9SLA8", "url": "https://omabrowser.org/oma/group/A0AAA9SLA8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LGP6-1", "protein_name": "Jade family PHD finger 2", "gene_name": "Jade2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFPDLLISLKGNWDLSRHYHHSVCVCWPPCGPLTPIGRLLFVHVPPRGLLSKKLALWMEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLKGPPTLMSPESPTLGEGAHPDWPGGSRYDLDEIDAYWLELLNSELKEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSTPSCLTAFHVTCAFDRGLEMRTILADNDEVKFKSLCQEHSDGGPRSEPSSEPVEPSQAVEDLEKVTLRKQRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQDLCREPSGRRSKGKKNDSKRKGREGPKGSSPEKKEKMKAGPESVLGQLGLSTSFPIDGTFFNSWLAQSVQITAEDMAMSEWSLNSGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPLQDGPSARTTPEKPAKKAWAQDGKGTQGPPARKPPRRTSSHLPSSPAAGDCPVPATLESPPTLASEILDETVPAASDLNVQVPGPTVSPKPLGRLRPPREMKVSRKSPGARSDAGTGLPSTVAERPKVSLHFDTEADGYFSDEEMSDSDVEAENRGVQRASREAGAEEVVRMGVLAS", "length": 886 }, "evidence": [ { "id": "A0AAA9SLA8", "url": "https://omabrowser.org/oma/group/A0AAA9SLA8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZQF7-1", "protein_name": "E3 ubiquitin-protein ligase Jade-2", "gene_name": "Jade2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEKRRKYSISSDNSDTTDGHVTSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRLLPPLKGPPTQMSPDSPTLGEGAHPDWPGGSRYDLDEIDAYWLELLNSELKEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCITAFHVTCAFDRGLEMRTILADNDEVKFKSLCQEHSDGGPRSEPTSEPVEPSQAVEDLEKVTLRKQRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRRANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHTICKLQEQIFHLQMKLIEQDLCREPSGRRSKGKKNDSKRKGREGPKGSSPEKKEKVKAGPESVLGQLGLSTSFPIDGTFFNSWLAQSVQITAEDMAMSEWSLNSGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPSPLQDGPSARTTPDKQPKKAWAQDGKGTQGPPMRKPPRRTSSHLPSSPAAGDCPVPATLESPPPLASEILDKTAPMASDLNVQVPGPTVSPKPLGRLRPPREMKVSRKSPGARSDAGTGLPSAVAERPKVSLHFDTEADGYFSDEEMSDSEVEAEDSGVQRASREAGAEEVVRMGVLAS", "length": 829 }, "evidence": [ { "id": "A0AAA9SLA8", "url": "https://omabrowser.org/oma/group/A0AAA9SLA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQC1-1", "protein_name": "E3 ubiquitin-protein ligase Jade-2", "gene_name": "JADE2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS", "length": 790 }, "evidence": [ { "id": "A0AAA9SLA8", "url": "https://omabrowser.org/oma/group/A0AAA9SLA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" }, { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" }, { "name": "histone acetyltransferase complex", "id": "GO:0000123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLA8" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" }, { "id": "PS51805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 231, "end_pos": 281, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 731, 770 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKH1-1", "uniprot_ac": "A0AAA9SKH1", "uniprot_id": "A0AAA9SKH1_BOVIN", "mass": { "chemical_mass": 43886.0, "monoisotopic_mass": 43886.0 }, "refseq": {}, "gene_names": [ { "name": "GTF2E2", "type": "recommended", "evidence": [ { "id": "A0AAA9SKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ] } ], "protein_names": [ { "name": "Ral transcription factor IIE subunit 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RUN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUN7#function" }, { "database": "UniProtKB", "id": "ARBA00025581", "url": "https://www.uniprot.org/uniprotkb/ARBA00025581#function" }, { "database": "UniProtKB", "id": "A0AAA9SYE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE0#function" }, { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1#function" }, { "database": "UniProtKB", "id": "A0AAA9T6R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R5#function" }, { "database": "UniProtKB", "id": "F1MUX7", "url": "https://www.uniprot.org/uniprotkb/F1MUX7#function" }, { "database": "UniProtKB", "id": "PIRNR016398", "url": "https://www.uniprot.org/uniprotkb/PIRNR016398#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF2E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1", "locus": { "chromosome": "27", "start_pos": 26642015, "end_pos": 26783526, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012691", "url": "https://www.ensembl.org/id/ENSBTAG00000012691" } ] } } ], "crossref": [ { "id": "A0AAA9SKH1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012691", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012691", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07977", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07977", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AFKRRAM", "url": "https://omabrowser.org/oma/group/AFKRRAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MUX7", "url": "https://www.orthodb.org/?gene=F1MUX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12716:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12716:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18121", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18121", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73776", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73779", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75953", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76042", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RUN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6R5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUX7", "url": "https://www.uniprot.org/uniprotkb/F1MUX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUX7-1", "url": "https://www.uniprot.org/uniprotkb/F1MUX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQDSGPKKVDVLADLEANLKYRTSSSNLSPRYSWAQASCEETLVFCGRKKGLWTINKTLPLPEPHLGPRSFLNTSQFCVQISWVALIKNPPVSAGDMRDVGWIPGSGRPLEEEMATHFSILAWRISIREEPGRLQSRGLQSQTRLSD", "length": 389, "header": "tr|A0AAA9SKH1-1|A0AAA9SKH1_BOVIN Isoform 1 of Ral transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=4 SV=1 CANONICAL=A0AAA9SKH1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1/entry#A0AAA9RUN7-1", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEARQASLSITNSQSSLRLKSIESVMPSSHLIFCRPLLLLPPILPSIRIFSNESALRMKWPKYWSFIFSISPSNEHPGLISFRMDWLDLLAV", "length": 302, "header": "tr|A0AAA9RUN7-1|A0AAA9SKH1_BOVIN Computationally mapped isoform of Ral transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=4 SV=1 CANONICAL=A0AAA9SKH1-1" }, "locus": { "chromosome": "27", "start_pos": 26778519, "end_pos": 26709860, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100061.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100061.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074651.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074651.1" } ] } }, { "isoform_ac": "A0AAA9SKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1/entry#A0AAA9SKH1-1", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQDSGPKKVDVLADLEANLKYRTSSSNLSPRYSWAQASCEETLVFCGRKKGLWTINKTLPLPEPHLGPRSFLNTSQFCVQISWVALIKNPPVSAGDMRDVGWIPGSGRPLEEEMATHFSILAWRISIREEPGRLQSRGLQSQTRLSD", "length": 389, "header": "tr|A0AAA9SKH1-1|A0AAA9SKH1_BOVIN Isoform 1 of Ral transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=4 SV=1 CANONICAL=A0AAA9SKH1-1" }, "locus": { "chromosome": "27", "start_pos": 26778519, "end_pos": 26696264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110128.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110128.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083110.1" } ] } }, { "isoform_ac": "A0AAA9SYE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1/entry#A0AAA9SYE0-1", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEARQASLSITNSQSSLRLKSIESVMPSSHLIFCRPLLLLPPILPSIRIFSNESALRMKVSETVEECHRGFNGRGEN", "length": 287, "header": "tr|A0AAA9SYE0-1|A0AAA9SYE0_BOVIN Computationally mapped isoform of Ral transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=4 SV=1 CANONICAL=A0AAA9SKH1-1" }, "locus": { "chromosome": "27", "start_pos": 26778519, "end_pos": 26705025, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115710.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115710.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090382.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090382.1" } ] } }, { "isoform_ac": "A0AAA9T6R5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1/entry#A0AAA9T6R5-1", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEARQASLSITNSRSSLRLMSIESVMPSSHLILSRPLLLLPPIPPSIRVFSSESTLLMRWPKYWSFSFSIIPSKEIPGLISFRMDW", "length": 296, "header": "tr|A0AAA9T6R5-1|A0AAA9T6R5_BOVIN Computationally mapped isoform of Ral transcription factor IIE subunit 2 OS=Bos taurus OX=9913 GN=GTF2E2 PE=4 SV=1 CANONICAL=A0AAA9SKH1-1" }, "locus": { "chromosome": "27", "start_pos": 26778519, "end_pos": 26642017, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103391.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103391.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092278.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092278.1" } ] } }, { "isoform_ac": "F1MUX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1/entry#F1MUX7-1", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEGQEACCYTFSYVIWDNLIEVSLWLTEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQDSGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDIAPGK", "length": 315, "header": "tr|F1MUX7-1|F1MUX7_BOVIN Computationally mapped isoform of Transcription initiation factor IIE subunit beta OS=Bos taurus OX=9913 GN=GTF2E2 PE=3 SV=2 CANONICAL=A0AAA9SKH1-1" }, "locus": { "chromosome": "27", "start_pos": 26778519, "end_pos": 26703616, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016863.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016863.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016863.4", "url": "https://www.ensembl.org/id/ENSBTAP00000016863.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-BTA-73776", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "resource": "Reactome", "description": "RNA Polymerase II Promoter Escape" }, { "id": "R-BTA-73779", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "resource": "Reactome", "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" }, { "id": "R-BTA-75953", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation" }, { "id": "R-BTA-76042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZCP9-1", "protein_name": "Transcription initiation factor IIE subunit beta", "gene_name": "Gtf2e2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMNSNVEVIMDPSLLRDRELFKKRALSTPVVEKRAVPSESPSSSSKKKKAKVEHGGSSGSKQNSDHNNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVSRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITPGK", "length": 300 }, "evidence": [ { "id": "A0AAA9SKH1", "url": "https://omabrowser.org/oma/group/A0AAA9SKH1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RX65-1", "protein_name": "Transcription initiation factor IIE subunit beta", "gene_name": "GTF2E2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPSLLRERELFRKRALSTPVVEKRSVSSESSSSSSKKKKAKLEHGGSSSSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNLKDKKALLRLLDKHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDIAPGK", "length": 290 }, "evidence": [ { "id": "A0AAA9SKH1", "url": "https://omabrowser.org/oma/group/A0AAA9SKH1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H610-1", "protein_name": "Transcription initiation factor IIE subunit beta", "gene_name": "Gtf2e2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPSLLRDRELFKKRALSTPVVEKRAVPSELPSASSKKKKAKVEHGGSSGSKQNADHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEDYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITPGK", "length": 291 }, "evidence": [ { "id": "A0AAA9SKH1", "url": "https://omabrowser.org/oma/group/A0AAA9SKH1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O96881-1", "protein_name": "Transcription initiation factor IIE subunit beta", "gene_name": "TfIIEbeta", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDPALLREREAFKKRAMATPTVEKKSKPDRPAPPPPSDDSRRKMRPPNAPRLDATTYKTMSGSSQYRFGVLAKIVKFMRTRHQDGDDHPLTIDEILDETNQLDIGQSVKNWLASEALHNNPKVEASPCGTKFSFKPVYKIKDGKTLMRLLKQHDLKGLGGILLDDVQESLPHCEKVLKNRSAEILFVVRPIDKKKILFYNDRTANFSVDDEFQKLWRSATVDAMDDAKIDEYLEKQGIRSMQDHGLKKAIPKRKKAANKKRQFKKPRDNEHLADVLEVYEDNTLTLKGVNPT", "length": 292 }, "evidence": [ { "id": "A0AAA9SKH1", "url": "https://omabrowser.org/oma/group/A0AAA9SKH1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P29084-1", "protein_name": "Transcription initiation factor IIE subunit beta", "gene_name": "GTF2E2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPSLLRERELFKKRALSTPVVEKRSASSESSSSSSKKKKTKVEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLDEILDETQHLDIGLKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNVRDKKALLRLLDQHDQRGLGGILLEDIEEALPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITSSK", "length": 291 }, "evidence": [ { "id": "A0AAA9SKH1", "url": "https://omabrowser.org/oma/group/A0AAA9SKH1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D902-1", "protein_name": "General transcription factor IIE subunit 2", "gene_name": "Gtf2e2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPSLLRDRELFKKRALSTPVVEKRAVPSESPSSSSSKKKKAKVEHGGSSGSKQNSDHNNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMTEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDNHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVSRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVASIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITPGK", "length": 292 }, "evidence": [ { "id": "A0AAA9SKH1", "url": "https://omabrowser.org/oma/group/A0AAA9SKH1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "transcription factor TFIIE complex", "id": "GO:0005673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005673", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" }, { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" }, { "name": "RNA polymerase II preinitiation complex assembly", "id": "GO:0051123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKH1" }, { "id": "PS51351", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51351" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TFIIE beta", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 144, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 269, "end_pos": 271 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SJC6-1", "uniprot_ac": "A0AAA9SJC6", "uniprot_id": "A0AAA9SJC6_BOVIN", "mass": { "chemical_mass": 29040.0, "monoisotopic_mass": 29040.0 }, "refseq": {}, "gene_names": [ { "name": "BOLA-DMA", "type": "recommended", "evidence": [ { "id": "A0AAA9SJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ] } ], "protein_names": [ { "name": "Major histocompatibility complex, class II, DM alpha", "type": "synonym", "evidence": [ { "id": "A0AAA9SJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BOLA-DMA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SJC6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SJC6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015730", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015730", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ADWAHQH", "url": "https://omabrowser.org/oma/group/ADWAHQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLV2", "url": "https://www.orthodb.org/?gene=F1MLV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19944:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19944:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00993", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00993", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLV2", "url": "https://www.uniprot.org/uniprotkb/F1MLV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MLV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHESESEVVSDSYRPHGLQPTRLLHPWDFPAPAPGWRDELQNHTFLHTMYCQDWSPNVALSESYDEDQLFSFDFSQSIRVPRLPEFADWAHQHGDTSDIMFDKGFCRAMIEEIGSELEGQIPVSRGFPIVQVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQHQSAPVEGAGPTFVSAVDGLTFQAFSYLNVTPAPSDLFSCIVTHEIDGYTAIAFWVPQNALPSDLLENVLCGVAFGLGVLGIIVGLVLFYCRKPCLGG", "length": 261, "header": "tr|A0AAA9SJC6-1|A0AAA9SJC6_BOVIN Isoform 1 of Major histocompatibility complex, class II, DM alpha OS=Bos taurus OX=9913 GN=BOLA-DMA PE=3 SV=1 CANONICAL=A0AAA9SJC6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6/entry#A0AAA9SJC6-1", "sequence": { "sequence": "MHESESEVVSDSYRPHGLQPTRLLHPWDFPAPAPGWRDELQNHTFLHTMYCQDWSPNVALSESYDEDQLFSFDFSQSIRVPRLPEFADWAHQHGDTSDIMFDKGFCRAMIEEIGSELEGQIPVSRGFPIVQVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQHQSAPVEGAGPTFVSAVDGLTFQAFSYLNVTPAPSDLFSCIVTHEIDGYTAIAFWVPQNALPSDLLENVLCGVAFGLGVLGIIVGLVLFYCRKPCLGG", "length": 261, "header": "tr|A0AAA9SJC6-1|A0AAA9SJC6_BOVIN Isoform 1 of Major histocompatibility complex, class II, DM alpha OS=Bos taurus OX=9913 GN=BOLA-DMA PE=3 SV=1 CANONICAL=A0AAA9SJC6-1" }, "locus": { "chromosome": "23", "start_pos": 7270417, "end_pos": 7264068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115907.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115907.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082691.1" } ] } }, { "isoform_ac": "A0AAA9SV51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6/entry#A0AAA9SV51-1", "sequence": { "sequence": "MDHELSQEDVLLRLLSFLWLLPLSWTAPEGFPIVQVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQHQSAPVEGAGPTFVSAVDGLTFQAFSYLNVTPAPSDLFSCIVTHEIDGYTAIAFWVPQNALPSDLLENVLCGVAFGLGVLGIIVGLVLFYCRKPCLGG", "length": 165, "header": "tr|A0AAA9SV51-1|A0AAA9SV51_BOVIN Computationally mapped isoform of Major histocompatibility complex, class II, DM alpha OS=Bos taurus OX=9913 GN=BOLA-DMA PE=4 SV=1 CANONICAL=A0AAA9SJC6-1" }, "locus": { "chromosome": "23", "start_pos": 7269056, "end_pos": 7264068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119897.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119897.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087851.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087851.1" } ] } }, { "isoform_ac": "A0AAA9SXT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6/entry#A0AAA9SXT6-1", "sequence": { "sequence": "MGPGPGVVRVCRVGSLRGVVWFHSGSVGTTLVVPAAGSGAPAPGWRDELQNHTFLHTMYCQDWSPNVALSESYDEDQLFSFDFSQSIRVPRLPEFADWAHQHGDTSDIMFDKGFCRAMIEEIGSELEGQIPVSRGFPIVQVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQHQSAPVEGAGPTFVSAVDGLTFQAFSYLNVTPAPSDLFSCIVTHEIDGYTAIAFWVPQNALPSDLLENVLCGVAFGLGVLGIIVGLVLFYCRKPCLGG", "length": 270, "header": "tr|A0AAA9SXT6-1|A0AAA9SXT6_BOVIN Computationally mapped isoform of Major histocompatibility complex, class II, DM alpha OS=Bos taurus OX=9913 GN=BOLA-DMA PE=3 SV=1 CANONICAL=A0AAA9SJC6-1" }, "locus": { "chromosome": "23", "start_pos": 7282331, "end_pos": 7264068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103721.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103721.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088122.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088122.1" } ] } }, { "isoform_ac": "A0AAA9T4Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6/entry#A0AAA9T4Q8-1", "sequence": { "sequence": "MAAAARERALRRRKAPAPGWRDELQNHTFLHTMYCQDWSPNVALSESYDEDQLFSFDFSQSIRVPRLPEFADWAHQHGDTSDIMFDKGFCRAMIEEIGSELEGQIPVSRGFPIVQVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQHQSAPVEGAGPTFVSAVDGLTFQAFSYLNVTPAPSDLFSCIVTHEIDGYTAIAFWVPQNALPSDLLENVLCGVAFGLGVLGIIVGLVLFYCRKPCLGG", "length": 245, "header": "tr|A0AAA9T4Q8-1|A0AAA9T4Q8_BOVIN Computationally mapped isoform of Major histocompatibility complex, class II, DM alpha OS=Bos taurus OX=9913 GN=BOLA-DMA PE=3 SV=1 CANONICAL=A0AAA9SJC6-1" }, "locus": { "chromosome": "23", "start_pos": 7282675, "end_pos": 7264068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120048.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120048.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090710.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090710.1" } ] } }, { "isoform_ac": "F1MLV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6/entry#F1MLV2-1", "sequence": { "sequence": "MPRAVEGSELEKHDLGRNLGTWVSWLVVPSPPGRCEDMDHELSQEDVLLRLLSFLWLLPLSWTAPEAPAPGWRDELQNHTFLHTMYCQDWSPNVALSESYDEDQLFSFDFSQSIRVPRLPEFADWAHQHGDTSDIMFDKGFCRAMIEEIGSELEGQIPVSRGFPIVQVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQHQSAPVEGAGPTFVSAVDGLTFQAFSYLNVTPAPSDLFSCIVTHEIDGYTAIAFWVPQNALPSDLLENVLCGVAFGLGVLGIIVGLVLFYCRKPCLGG", "length": 297, "header": "tr|F1MLV2-1|F1MLV2_BOVIN Computationally mapped isoform of Major histocompatibility complex, class II, DM alpha OS=Bos taurus OX=9913 GN=BOLA-DMA PE=3 SV=3 CANONICAL=A0AAA9SJC6-1" }, "locus": { "chromosome": "23", "start_pos": 7269167, "end_pos": 7264068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020881.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020881.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020881.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020881.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 194, "start_aa": "Thr", "end_pos": 194, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr194", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XF89-1", "protein_name": "Major histocompatibility complex B, class II alpha chain DMA", "gene_name": "DMA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRRRLRPGPAARPHISGENGGGAWMERGDLPALRCAQNPPRRRRYRAGKAEPSLHTLSEVLFCQPDTPSLGLSVAFDSEQLFSFDVPNSQWLPQLPDGPSWPADIEQPHELLHDAALCRELLDLLTRIATGPNPMPEAKGIPVADVFLQQPLQLGYPNTLICMVGNIFPPAITISWQRDGIPVTDGVTHLTYTPTEDLGFMRFSYLAVTPHSGDIYACIVTRERDNISVVAYWVPQDPIPSDVLATAVCGAVTALGILLALLGLGLLLSARRRSMWGQWRQQGHPPRTH", "length": 289 }, "evidence": [ { "id": "A0AAA9SJC6", "url": "https://omabrowser.org/oma/group/A0AAA9SJC6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HQS6-1", "protein_name": "Class II histocompatibility antigen, M alpha chain", "gene_name": "LOC100760794", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDQEQKPGAGLLHLLQLLCLLPRCWAVPGGAPAPVLWEGLQNHTFRHTVFCQDGNPSIGLSESYDEDQLFYDFSQNTRVPRLPDFADWAQEQGDASAISFDKEFCNMLIQEIGPQLEGLIPVSRGLPVPEVFTLKPLEFGKPNTLVCFISNLFPPTLTVSWQHHFVPVEGASPTYISAIDGLTFQAFSYLNFTPEPFDIYSCVVTHEIDSYTPIAHWVPQNALPSDLLENVLCGLAFGLGLLGIITGIAFFIWSQKPCSVD", "length": 261 }, "evidence": [ { "id": "A0AAA9SJC6", "url": "https://omabrowser.org/oma/group/A0AAA9SJC6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P28067-1", "protein_name": "HLA class II histocompatibility antigen, DM alpha chain", "gene_name": "HLA-DMA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGHEQNQGAALLQMLPLLWLLPHSWAVPEAPTPMWPDDLQNHTFLHTVYCQDGSPSVGLSEAYDEDQLFFFDFSQNTRVPRLPEFADWAQEQGDAPAILFDKEFCEWMIQQIGPKLDGKIPVSRGFPIAEVFTLKPLEFGKPNTLVCFVSNLFPPMLTVNWQHHSVPVEGFGPTFVSAVDGLSFQAFSYLNFTPEPSDIFSCIVTHEIDRYTAIAYWVPRNALPSDLLENVLCGVAFGLGVLGIIVGIVLIIYFRKPCSGD", "length": 261 }, "evidence": [ { "id": "A0AAA9SJC6", "url": "https://omabrowser.org/oma/group/A0AAA9SJC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "MHC class II protein complex", "id": "GO:0042613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042613", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", "id": "GO:0002504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002504", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "antigen processing and presentation of exogenous peptide antigen via MHC class II", "id": "GO:0019886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "peptide antigen assembly with MHC class II protein complex", "id": "GO:0002503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002503", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "positive regulation of T cell activation", "id": "GO:0050870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050870", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "positive regulation of immune response", "id": "GO:0050778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050778", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "MHC class II protein complex binding", "id": "GO:0023026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023026", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" }, { "name": "peptide antigen binding", "id": "GO:0042605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SJC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 207, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 194 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 192, "end_pos": 194 }, { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SKT2-1", "uniprot_ac": "A0AAA9SKT2", "uniprot_id": "A0AAA9SKT2_BOVIN", "mass": { "chemical_mass": 67829.0, "monoisotopic_mass": 67829.0 }, "refseq": {}, "gene_names": [ { "name": "MIGA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SKT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2" } ] } ], "protein_names": [ { "name": "Mitoguardin 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SKT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MIGA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2", "locus": { "chromosome": "3", "start_pos": 66805921, "end_pos": 66884724, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031044", "url": "https://www.ensembl.org/id/ENSBTAG00000031044" } ] } } ], "crossref": [ { "id": "A0AAA9SKT2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SKT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031044", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031044", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MNB3", "url": "https://www.orthodb.org/?gene=F1MNB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21508:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10265", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10265", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SKT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNB3", "url": "https://www.uniprot.org/uniprotkb/F1MNB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNB3-1", "url": "https://www.uniprot.org/uniprotkb/F1MNB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEETVSESQFSLKTAALRVFDLPLSWYYSLCQIKFSPVAKKLFMVTAVSAVSVIFLAHHFKRRRGKKKGKILPWEPEHLILECTKRAASDKGSSCSSSRQNLTLSLSSAKDKGSQSCNYVNGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEESVDDIISTEFIHKLESLLQRAYRLQEEFEATLGASDPNSLVNDTDKDTDVTMKGNADDFSLRDTLSVASTDSFTSTAELAEHKEARHTYSLESLCHCPFYEEAMRLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSETANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWDNTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKQIPDGFFAHFYAICEQISPVLAWGFLGPRNSLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIESLAEDLMQLLVRRTELLMACLGADALRHTSSCLNSHVPVMPSGLLEAKVQ", "length": 601, "header": "tr|A0AAA9SKT2-1|A0AAA9SKT2_BOVIN Isoform 1 of Mitoguardin 1 OS=Bos taurus OX=9913 GN=MIGA1 PE=3 SV=2 CANONICAL=A0AAA9SKT2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2/entry#A0AAA9SKT2-1", "sequence": { "sequence": "MSEETVSESQFSLKTAALRVFDLPLSWYYSLCQIKFSPVAKKLFMVTAVSAVSVIFLAHHFKRRRGKKKGKILPWEPEHLILECTKRAASDKGSSCSSSRQNLTLSLSSAKDKGSQSCNYVNGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEESVDDIISTEFIHKLESLLQRAYRLQEEFEATLGASDPNSLVNDTDKDTDVTMKGNADDFSLRDTLSVASTDSFTSTAELAEHKEARHTYSLESLCHCPFYEEAMRLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSETANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWDNTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKQIPDGFFAHFYAICEQISPVLAWGFLGPRNSLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIESLAEDLMQLLVRRTELLMACLGADALRHTSSCLNSHVPVMPSGLLEAKVQ", "length": 601, "header": "tr|A0AAA9SKT2-1|A0AAA9SKT2_BOVIN Isoform 1 of Mitoguardin 1 OS=Bos taurus OX=9913 GN=MIGA1 PE=3 SV=2 CANONICAL=A0AAA9SKT2-1" }, "locus": { "chromosome": "3", "start_pos": 66879501, "end_pos": 66808581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100779.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100779.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084488.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084488.2" } ] } }, { "isoform_ac": "A0AAA9T3X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2/entry#A0AAA9T3X8-1", "sequence": { "sequence": "MSEETVSESQFSLKTAALRVFDLPLSWYYSLCQIKFSPVAKKLFMVTAVSAVSVIFLAHHFKRRRGKKKGKILPWEPEHLILECTKRAASDKGSSCSSSRQNLTLSLSSAKDKGSQSCNYVNGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEESVDDIISTEFIHKLESLLQRAYRLQEEFEATLGASDPNSLVNDTDKDTDVTMKGNADDFSLRDTLSVASTDSFTSTAELAEHKEARHTYSLESLCHCPFYEEAMRLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSETANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWDNTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKDYNMFIKCQNEILF", "length": 503, "header": "tr|A0AAA9T3X8-1|A0AAA9T3X8_BOVIN Computationally mapped isoform of Mitoguardin 1 OS=Bos taurus OX=9913 GN=MIGA1 PE=3 SV=1 CANONICAL=A0AAA9SKT2-1" }, "locus": { "chromosome": "3", "start_pos": 66879501, "end_pos": 66805921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090502.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090502.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091201.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091201.1" } ] } }, { "isoform_ac": "F1MNB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2/entry#F1MNB3-1", "sequence": { "sequence": "MSDSVRPRRWQPTRLPRPWDSPAIRERQEPLPSTEMAGAASHVAPHAERLGGPRYFLSTFPFLTPEGLRPRGQAAAQRRAAAGKQAWTGCTGPGASDRRGVMSEETVSESQFSLKTAALRVFDLPLSWYYSLCQIKFSPVAKKLFMVTAVSAVSVIFLAHHFKRRRGKKKGKILPWEPEHLILECTKRAASDKGSSCSSSRQNLTLSLSSAKDKGSQSCNYVNGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEESVDDIISTEFIHKLESLLQRAYRLQEEFEATLGASDPNSLVNDTDKDTDVTMKGNADDFSLRDTLSVASTDSFTSTAELAEHKEARHTYSLESLCHCPFYEEAMRLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSETANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWDNTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEQISPVLAWGFLGPRNSLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIESLAEDLMQLLVRRTELLMACLGADALRHTSSCLNSHVPVMPSGLLEAKVQ", "length": 701, "header": "tr|F1MNB3-1|F1MNB3_BOVIN Computationally mapped isoform of Mitoguardin 1 OS=Bos taurus OX=9913 GN=MIGA1 PE=3 SV=4 CANONICAL=A0AAA9SKT2-1" }, "locus": { "chromosome": "3", "start_pos": 66884628, "end_pos": 66808581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043938.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043938.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041471.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041471.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1483166", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "resource": "Reactome", "description": "Synthesis of PA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial fusion", "id": "GO:0008053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008053", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 465, "end_pos": 467 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SLB5-1", "uniprot_ac": "A0AAA9SLB5", "uniprot_id": "A0AAA9SLB5_BOVIN", "mass": { "chemical_mass": 35505.0, "monoisotopic_mass": 35505.0 }, "refseq": {}, "gene_names": [ { "name": "LOC785762", "type": "recommended", "evidence": [ { "id": "A0AAA9SLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5" } ] } ], "protein_names": [ { "name": "NADP-dependent oxidoreductase domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC785762", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SLB5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SLB5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR018170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11732", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPKSQRVKLNDGHFIPVLGFGTYAPPEVAKKEALEFTPFAIEVGFRHIDCAHAYQNEEEIGQVIRSKIADGTVKREDIFCTSKLWLTSLRPELVRPALEKSLKNLQLDYVDLYIMHYPMALKPGEELFPKDENGKLIFDSVDFCRTWEALEKCKDAGLAKSIGVSNFNHKQLERILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSHEIVLVAYAGLGSQRVKEWVNQNHPVLLEDPVLSAIAQKHKKTAALVALRYQIQRGVVVLAKGNNKKWIKENMQVFDFELTPEDMKAIDGLNRNIRYYELHL", "length": 310, "header": "tr|A0AAA9SLB5-1|A0AAA9SLB5_BOVIN Isoform 1 of NADP-dependent oxidoreductase domain-containing protein OS=Bos taurus OX=9913 GN=LOC785762 PE=3 SV=1 CANONICAL=A0AAA9SLB5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5/entry#A0AAA9SLB5-1", "sequence": { "sequence": "MDPKSQRVKLNDGHFIPVLGFGTYAPPEVAKKEALEFTPFAIEVGFRHIDCAHAYQNEEEIGQVIRSKIADGTVKREDIFCTSKLWLTSLRPELVRPALEKSLKNLQLDYVDLYIMHYPMALKPGEELFPKDENGKLIFDSVDFCRTWEALEKCKDAGLAKSIGVSNFNHKQLERILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSHEIVLVAYAGLGSQRVKEWVNQNHPVLLEDPVLSAIAQKHKKTAALVALRYQIQRGVVVLAKGNNKKWIKENMQVFDFELTPEDMKAIDGLNRNIRYYELHL", "length": 310, "header": "tr|A0AAA9SLB5-1|A0AAA9SLB5_BOVIN Isoform 1 of NADP-dependent oxidoreductase domain-containing protein OS=Bos taurus OX=9913 GN=LOC785762 PE=3 SV=1 CANONICAL=A0AAA9SLB5-1" }, "locus": { "chromosome": "13", "start_pos": 43489395, "end_pos": 43480015, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091736.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091736.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084705.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084705.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLB5" }, { "id": "PF00248", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADP-dependent oxidoreductase", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 300, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQM4-1", "uniprot_ac": "A0AAA9SQM4", "uniprot_id": "A0AAA9SQM4_BOVIN", "mass": { "chemical_mass": 39869.0, "monoisotopic_mass": 39869.0 }, "refseq": {}, "gene_names": [ { "name": "HEMK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ] } ], "protein_names": [ { "name": "peptide chain release factor N(5)-glutamine methyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.297", "type": "synonym", "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEMK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4", "locus": { "chromosome": "22", "start_pos": 49766190, "end_pos": 49789106, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004120", "url": "https://www.ensembl.org/id/ENSBTAG00000004120" } ] } } ], "crossref": [ { "id": "A0AAA9SQM4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004120", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004120", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515459", "url": "https://www.ncbi.nlm.nih.gov/gene/515459", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004556", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004556", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR18895", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18895", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18895:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18895:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17827", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17827", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "42896", "url": "https://www.rhea-db.org/rhea/42896", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJ55-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWY4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC55", "url": "https://www.uniprot.org/uniprotkb/F1MC55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC55-1", "url": "https://www.uniprot.org/uniprotkb/F1MC55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VEHQGRMLRALLSGLGWRKGIWGCAFSSWQPHQPPAGLSATEVVSHWTVVFEEKGIPEARESSEYIVAHVLGAKTFQSLRPALRTQPLTPWQLQCIQELSSYRLQRMPVQYILGEWDFQGLNLKMAPPVFIPRPETEELVEWVLEEVTQGPRVVGAEGGPLILEVGCGSGAISLSLLSRLPQSRVTAVDKGEAAICLTHENAQRLRLQDRIQIVPFDVTLVESWAHLLPWGPVDLVVSNPPYVFHRDMENLAPEILRYEDPVALDGGEEGMDIITHILALAPQLLKDSGSIFLEVDPRHPELVGSWLQSQPDLPLNLVAVRRDFRGRPRFLHIRRSGPQCVSPVDAWPGRQPARVPG", "length": 357, "header": "tr|A0AAA9SQM4-1|A0AAA9SQM4_BOVIN Isoform 1 of peptide chain release factor N(5)-glutamine methyltransferase OS=Bos taurus OX=9913 GN=HEMK1 PE=4 SV=1 CANONICAL=A0AAA9SQM4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJ55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4/entry#A0A3Q1LJ55-1", "sequence": { "sequence": "MLRALLSGLGWRKGIWGCAFSSWQPHQPPAGLSATEVVSHWTVVFEEKGIPEARESSEYIVAHVLGAKTFQSLRPALRTQPLTPWQLQCIQELSSYRLQRMPVQYILGEWDFQGLNLKMAPPVFIPRPETEELVEWVLEEVTQGPRVVGAEGGPLILEVGCGSGAISLSLLSRLPQSRVTAVDKGEAAICLTHENAQRLRLQDRIQIVPFDVTLVESWAHLLPWGPVDLVVSNPPYVFHRDMENLAPEILRYEDPVALDGGEEGMDIITHILALAPQLLKDSGRWAGGWPSLAHEALNPIMPAVPSLLSNHDWEPKIDCRTYPWCWSMKERWTETPHQELMAKWKTEEPGRL", "length": 352, "header": "tr|A0A3Q1LJ55-1|A0A3Q1LJ55_BOVIN Computationally mapped isoform of peptide chain release factor N(5)-glutamine methyltransferase OS=Bos taurus OX=9913 GN=HEMK1 PE=4 SV=2 CANONICAL=A0AAA9SQM4-1" }, "locus": { "chromosome": "22", "start_pos": 49787154, "end_pos": 49766929, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059326.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059326.2" } ] } }, { "isoform_ac": "A0A3Q1MWY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4/entry#A0A3Q1MWY4-1", "sequence": { "sequence": "MLRALLSGLGWRKGIWGCAFSSWQPHQPPAGLSATEVVSHWTVVFEEKGIPEARESSEYIVAHVLGAKTFQSLRPALRTQPLTPWQLQCIQELSSYRLQRMPVQYILGEWDFQGLNLKMAPPVFIPRPETEELVEWVLEEVTQGPRVVGAEGGPLILEVGCGSGAISLSLLSRLPQSRVTAVDKGEAAICLTHENAQRLRLQDRIQIVPFDVTLVESWAHLLPWGPVDLVVSNPPYVFHRDMENLAPEILRYEDPVALDGGEEGMDIITHILALAPQLLKDSGSIFLEVDPRHPELVGSWLQSQPDLPLNLVAVRRDFRGRALGWV", "length": 326, "header": "tr|A0A3Q1MWY4-1|A0AAA9SQM4_BOVIN Computationally mapped isoform of peptide chain release factor N(5)-glutamine methyltransferase OS=Bos taurus OX=9913 GN=HEMK1 PE=4 SV=2 CANONICAL=A0AAA9SQM4-1" }, "locus": { "chromosome": "22", "start_pos": 49787154, "end_pos": 49767977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084464.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084464.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060137.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060137.2" } ] } }, { "isoform_ac": "A0AAA9SQM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4/entry#A0AAA9SQM4-1", "sequence": { "sequence": "VEHQGRMLRALLSGLGWRKGIWGCAFSSWQPHQPPAGLSATEVVSHWTVVFEEKGIPEARESSEYIVAHVLGAKTFQSLRPALRTQPLTPWQLQCIQELSSYRLQRMPVQYILGEWDFQGLNLKMAPPVFIPRPETEELVEWVLEEVTQGPRVVGAEGGPLILEVGCGSGAISLSLLSRLPQSRVTAVDKGEAAICLTHENAQRLRLQDRIQIVPFDVTLVESWAHLLPWGPVDLVVSNPPYVFHRDMENLAPEILRYEDPVALDGGEEGMDIITHILALAPQLLKDSGSIFLEVDPRHPELVGSWLQSQPDLPLNLVAVRRDFRGRPRFLHIRRSGPQCVSPVDAWPGRQPARVPG", "length": 357, "header": "tr|A0AAA9SQM4-1|A0AAA9SQM4_BOVIN Isoform 1 of peptide chain release factor N(5)-glutamine methyltransferase OS=Bos taurus OX=9913 GN=HEMK1 PE=4 SV=1 CANONICAL=A0AAA9SQM4-1" }, "locus": { "chromosome": "22", "start_pos": 49787172, "end_pos": 49778719, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135468.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135468.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086243.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086243.1" } ] } }, { "isoform_ac": "F1MC55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4/entry#F1MC55-1", "sequence": { "sequence": "MLRALLSGLGWRKGIWGCAFSSWQPHQPPAGLSATEVVSHWTVVFEEKGIPEARESSEYIVAHVLGAKTFQSLRPALRTQPLTPWQLQCIQELSSYRLQRMPVQYILGEWDFQGLNLKMAPPVFIPRPETEELVEWVLEEVTQGPRVVGAEGGPLILEVGCGSGAISLSLLSRLPQSRVTAVDKGEAAICLTHENAQRLRLQDRIQIVPFDVTLVESWAHLLPWGPVDLVVSNPPYVFHRDMENLAPEILRYEDPVALDGGEEGMDIITHILALAPQLLKDSGSIFLEVDPRHPELVGSWLQSQPDLPLNLVAVRRDFRGRRWAGGWPSLAHEALNPIMPAVPSLLSNHDWEPKIDCRTYPWCWSMKERWTETPHQELMAKWKTEEPGRL", "length": 390, "header": "tr|F1MC55-1|F1MC55_BOVIN Computationally mapped isoform of peptide chain release factor N(5)-glutamine methyltransferase OS=Bos taurus OX=9913 GN=HEMK1 PE=4 SV=4 CANONICAL=A0AAA9SQM4-1" }, "locus": { "chromosome": "22", "start_pos": 49787154, "end_pos": 49766929, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005382.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005382.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005382.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005382.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ], "pmid": "" }, { "name": "peptide chain release factor N(5)-glutamine methyltransferase activity", "id": "GO:0102559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102559", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ], "pmid": "" }, { "name": "protein-glutamine N-methyltransferase activity", "id": "GO:0036009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036009", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ], "pmid": "" }, { "name": "translational termination", "id": "GO:0006415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006415", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "42896", "name": "", "equation": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SQM4-1" ], "evidence": [ { "id": "42896", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42896" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SQM4", "gene_name": "HEMK1", "activity": [ { "ec_number": "2.1.1.297", "activity": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ] }, { "ec_number": "2.1.1.297", "activity": "", "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" }, { "id": "PF05175", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05175" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methyltransferase small", "eco_id": "ECO_0000259", "start_pos": 162, "end_pos": 247, "start_aa": "Ile", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM4" }, { "id": "PF17827", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17827" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Release factor glutamine methyltransferase N-terminal", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 114, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.297", "ec_name": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.297", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.297" }, { "id": "2.1.1.297", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.297" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SN40-1", "uniprot_ac": "A0AAA9SN40", "uniprot_id": "A0AAA9SN40_BOVIN", "mass": { "chemical_mass": 83149.0, "monoisotopic_mass": 83149.0 }, "refseq": {}, "gene_names": [ { "name": "HOOK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SN40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ] } ], "protein_names": [ { "name": "Hook microtubule tethering protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SN40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOOK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40", "locus": { "chromosome": "7", "start_pos": 12759568, "end_pos": 12747628, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008654", "url": "https://www.ensembl.org/id/ENSBTAG00000008654" } ] } } ], "crossref": [ { "id": "A0AAA9SN40", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SN40", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008654", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008654", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526516", "url": "https://www.ncbi.nlm.nih.gov/gene/526516", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MYN2", "url": "https://www.orthodb.org/?gene=A0A3Q1MYN2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BI15", "url": "https://www.orthodb.org/?gene=E1BI15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6Q5N6", "url": "https://www.orthodb.org/?gene=F6Q5N6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18947", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18947", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18947:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18947:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MYN2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MYN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MYN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MYN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI15", "url": "https://www.uniprot.org/uniprotkb/E1BI15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BI15-1", "url": "https://www.uniprot.org/uniprotkb/E1BI15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q5N6", "url": "https://www.uniprot.org/uniprotkb/F6Q5N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q5N6-1", "url": "https://www.uniprot.org/uniprotkb/F6Q5N6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSMDKEELCGSLLTWLQTFNVPPPCTSPQDLSSGLAVAFVLNQIDPSWFNEAWLQGISEDPGPNRRLKVSNLKAILQSLVEYSQDVLGHPILEQHLPDVSLIGEFSDPEELGKLLQLVLGCAISCEKKQEHIQRIMTLEESVQHVVMEAIQELMTKDTSDSLSPETYGNFDSQSRRYYFLSEEADEGDELRQRCLDLERQLVLLSEEKQSLAQENSVLRERVGRPEDEGASGLTAKKLLLLQTQLEQLQEENFRLESGREDERMRCVELEREVAELQQRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLNSCRRRLGELRELRRQVRQLEECNASHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGKRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQMQPRGLAQADPSLDPTSPAVGNLAAEILPAELRETLLRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSISILLKKKLEEHLQKLHEADLELQRKREYIEELEPPNDSSTARRIEELQHSLQKKDEDLRAVEERYRRYVDRARAVIQTLEPKQQPPGGAPLDLHALRTQLRERDVRIRHLEMDFDKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNARRGPLGRLATLNMRPADKH", "length": 719, "header": "tr|A0AAA9SN40-1|A0AAA9SN40_BOVIN Isoform 1 of Hook microtubule tethering protein 2 OS=Bos taurus OX=9913 GN=HOOK2 PE=3 SV=1 CANONICAL=A0AAA9SN40-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MYN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40/entry#A0A3Q1MYN2-1", "sequence": { "sequence": "MSMDKEELCGSLLTWLQTFNVPPPCTSPQDLSSGLAVAFVLNQIDPSWFNEAWLQGISEDPGPNRRLKVSNLKAILQSLVEYSQDVLGHPILEQHLPDVSLIGEFSDPEELGKLLQLVLGCAISCEKKQEHIQRIMTLEESVQHVVMEAIQESRRYYFLSEEADEGDELRQRCLDLERQLVLLSEEKQSLAQENSVLRERVGRPEDEGASGLTAKKLLLLQTQLEQLQEENFRLESGREDERMRCVELEREVAELQQRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLNSCRRRLGELRELRRQVRQLEECNASHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGKRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQMQPRGLAQADPSLDPTSPAVGNLAAEILPAELRETLLRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKKKLEEHLQKLHEADLELQRKREYIEELEPPNDSSTRRIEELQHSLQKKDEDLRAVEERYRRYVDRARAVIQTLEPKQQPPGGAPLDLHALRTQLRERDVRIRHLEMDFDKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNARRGPLGRLATLNMRPADKH", "length": 695, "header": "tr|A0A3Q1MYN2-1|A0AAA9SN40_BOVIN Computationally mapped isoform of Hook microtubule tethering protein 2 OS=Bos taurus OX=9913 GN=HOOK2 PE=3 SV=2 CANONICAL=A0AAA9SN40-1" }, "locus": { "chromosome": "7", "start_pos": 12759272, "end_pos": 12749149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070640.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070640.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061195.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061195.2" } ] } }, { "isoform_ac": "A0AAA9SN40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40/entry#A0AAA9SN40-1", "sequence": { "sequence": "MSMDKEELCGSLLTWLQTFNVPPPCTSPQDLSSGLAVAFVLNQIDPSWFNEAWLQGISEDPGPNRRLKVSNLKAILQSLVEYSQDVLGHPILEQHLPDVSLIGEFSDPEELGKLLQLVLGCAISCEKKQEHIQRIMTLEESVQHVVMEAIQELMTKDTSDSLSPETYGNFDSQSRRYYFLSEEADEGDELRQRCLDLERQLVLLSEEKQSLAQENSVLRERVGRPEDEGASGLTAKKLLLLQTQLEQLQEENFRLESGREDERMRCVELEREVAELQQRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLNSCRRRLGELRELRRQVRQLEECNASHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGKRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQMQPRGLAQADPSLDPTSPAVGNLAAEILPAELRETLLRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSISILLKKKLEEHLQKLHEADLELQRKREYIEELEPPNDSSTARRIEELQHSLQKKDEDLRAVEERYRRYVDRARAVIQTLEPKQQPPGGAPLDLHALRTQLRERDVRIRHLEMDFDKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNARRGPLGRLATLNMRPADKH", "length": 719, "header": "tr|A0AAA9SN40-1|A0AAA9SN40_BOVIN Isoform 1 of Hook microtubule tethering protein 2 OS=Bos taurus OX=9913 GN=HOOK2 PE=3 SV=1 CANONICAL=A0AAA9SN40-1" }, "locus": { "chromosome": "7", "start_pos": 12759272, "end_pos": 12749149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130047.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130047.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085307.1" } ] } }, { "isoform_ac": "E1BI15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40/entry#E1BI15-1", "sequence": { "sequence": "MWLQTFNVPPPCTSPQDLSSGLAVAFVLNQIDPSWFNEAWLQGISEDPGPNRRLKVSNLKAILQSLVEYSQDVLGHPILEQHLPDVSLIGEFSDPEELGKLLQLVLGCAISCEKKQEHIQRIMTLEESVQHVVMEAIQELMTKDTSDSLSPETYGNFDSQSRRYYFLSEEADEGDELRQRCLDLERQLVLLSEEKQSLAQENSVLRERVGRPEDEGASGLTAKKLLLLQTQLEQLQEENFRLESGREDERMRCVELEREVAELQQRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLNSCRRRLGELRELRRQVRQLEECNASHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGKRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQMQPRGLAQADPSLDPTSPAVGNLAAEILPAELRETLLRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKKKLEEHLQKLHEADLELQRKREYIEELEPPNDSSTARRIEELQHSLQKKDEDLRAVEERYRRYVDRARAVIQTLEPKQQPPGGAPLDLHALRTQLRERDVRIRHLEQMDFDKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNARRGPLGRLATLNMRPADKH", "length": 705, "header": "tr|E1BI15-1|E1BI15_BOVIN Computationally mapped isoform of Hook microtubule tethering protein 2 OS=Bos taurus OX=9913 GN=HOOK2 PE=3 SV=2 CANONICAL=A0AAA9SN40-1" }, "locus": { "chromosome": "7", "start_pos": 12759272, "end_pos": 12747758, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046060.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046060.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043388.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043388.3" } ] } }, { "isoform_ac": "F6Q5N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40/entry#F6Q5N6-1", "sequence": { "sequence": "MSMDKEELCGSLLTWLQTFNVPPPCTSPQDLSSGLAVAFVLNQIDPSWFNEAWLQGISEDPGPNRRLKVSNLKAILQSLVEYSQDVLGHPILEQHLPDVSLIGEFSDPEELGKLLQLVLGCAISCEKKQEHIQRIMTLEESVQHVVMEAIQELMTKDTSDSLSPETYGNFDSQSRRYYFLSEEADEGDELRQRCLDLERQLVLLSEEKQSLAQENSVLRERVGRPEDEGASGLTAKKLLLLQTQLEQLQEENFRLESGREDERMRCVELEREVAELQQRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLNSCRRRLGELRELRRQVRQLEECNASHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGKRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQMQPRGLAQADPSLDPTSPAVGNLAAEILPAELRETLLRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKKKLEEHLQKLHEADLELQRKREYIEELEPPNDSSTARRIEELQHSLQKKDEDLRAVEERYRRYVDRARAVIQTLEPKQQPPGGAPLDLHALRTQLRERDVRIRHLEQMDFDKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNARRGPLGRLATLNMRPADKH", "length": 718, "header": "tr|F6Q5N6-1|F6Q5N6_BOVIN Computationally mapped isoform of Hook microtubule tethering protein 2 OS=Bos taurus OX=9913 GN=HOOK2 PE=3 SV=2 CANONICAL=A0AAA9SN40-1" }, "locus": { "chromosome": "7", "start_pos": 12759272, "end_pos": 12749149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011411.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011411.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011411.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011411.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "HOPS complex", "id": "GO:0030897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "FHF complex", "id": "GO:0070695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070695", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cytoskeleton-dependent intracellular transport", "id": "GO:0030705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030705", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "endomembrane system organization", "id": "GO:0010256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010256", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "early endosome to late endosome transport", "id": "GO:0045022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" }, { "name": "protein localization to perinuclear region of cytoplasm", "id": "GO:1905719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905719", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SN40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN40" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 122, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 338, "end_pos": 340 }, { "start_pos": 571, "end_pos": 573 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNS6-1", "uniprot_ac": "A0AAA9SNS6", "uniprot_id": "A0AAA9SNS6_BOVIN", "mass": { "chemical_mass": 131880.0, "monoisotopic_mass": 131880.0 }, "refseq": {}, "gene_names": [ { "name": "SALL3", "type": "recommended", "evidence": [ { "id": "A0AAA9SNS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ] } ], "protein_names": [ { "name": "Sal-like protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SNS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable transcription factor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS63", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS63#function" }, { "database": "UniProtKB", "id": "ARBA00037260", "url": "https://www.uniprot.org/uniprotkb/ARBA00037260#function" }, { "database": "UniProtKB", "id": "A0A3Q1NGV0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGV0#function" }, { "database": "UniProtKB", "id": "A0AAA9RTI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTI8#function" }, { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6#function" }, { "database": "UniProtKB", "id": "A0AAA9T578", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T578#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SALL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6", "locus": { "chromosome": "24", "start_pos": 1060499, "end_pos": 1079337, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050200", "url": "https://www.ensembl.org/id/ENSBTAG00000050200" } ] } } ], "crossref": [ { "id": "A0AAA9SNS6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050200", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050200", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20908", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20908", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100138793", "url": "https://www.ncbi.nlm.nih.gov/gene/100138793", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NGV0", "url": "https://www.orthodb.org/?gene=A0A3Q1NGV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23233", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23233", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23233:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23233:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LS63", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS63-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGV0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T578", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T578", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T578-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T578-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEASQQIHLLMFQQSMVFGDMDLRVRGAHTPLRTTTKGRLEAVTCLCPAAPGEGTEDADSGNESRSGGEDTHVCEKCCAEFFKWADLLAHKEACTKNPLVLIVGEDEPAPPSEDFPEASPASSASERADSEAAEEAAAAAAAAPEGGEAVEARAPEREDEPMEVGAPADKGFQGPGAAHAGQPPPPPGPEPAPGAAYGMPSTNVTLETLLSTKVAVAQFSQTSRAAGAAGPGGGVAAAALPLILEQLVALQQQQVQQLQLIEQIRSQVALMSRPLPPSRPPLHPGPAAHPTLPLSAGTGPAATAQGPAAPPAAYEGPQHLAAPASTASTPHVAGGGPSVPEPGAPACSGAPATSTASTPAAGASGGTSRPQNAPTPPALGPGPLLTSTPSLPSPLLPQTSASTVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASTEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPALPTVPTSVGLQLPPTLPGVGVGSYVDSPSLTPASRSPQRPSPASSECPSLSPGLTSSEAGVPVAAGSPQPAPGGSSLPKTEPVSLPCTNARVGDLPATAGQVSTTSALADSSASPGLCSPVLPAGAEPFKAKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDAVLPYDDKAADALSACDDDMDDNSLEDDAELKDAAGDPNKPLLAFSGSCPPSPPSVISSIAALENQMKMMDSVMSCPQLSALKSLENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSLQALSPGNSNSESLPSKSPGLGAQEEPQETPLKTEKPDSPLPGPENGGALDLTATHPCRPSVKEEAPFSLLFLSRDRGPSQGTPSLGPGSTPTTIKTEVNGHSKAGLLAEGPPLPAAVQVPPGPPTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGLPQLPVSLSGSALPPLGSLAAGLDKARPGSSPPIAGLDKANSDTGGSRPFTRFIEDNKEIGIN", "length": 1273, "header": "tr|A0AAA9SNS6-1|A0AAA9SNS6_BOVIN Isoform 1 of Sal-like protein 3 OS=Bos taurus OX=9913 GN=SALL3 PE=3 SV=1 CANONICAL=A0AAA9SNS6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6/entry#A0A3Q1LS63-1", "sequence": { "sequence": "MLKWAAPGEGTEDADSGNESRSGGEDTHVCEKCCAEFFKWADLLAHKEACTKNPLVLIVGEDEPAPPSEDFPEASPASSASERADSEAAEEAAAAAAAAPEGGEAVEARAPEREDEPMEVGAPADKGFQGPGAAHAGQPPPPPGPEPAPGAAYGMPSTNVTLETLLSTKVAVAQFSQTSRAAGAAGPGGGVAAAALPLILEQLVALQQQQVQQLQLIEQIRSQVALMSRPLPPSRPPLHPGPAAHPTLPLSAGTGPAATAQGPAAPPAAYEGPQHLAAPASTASTPHVAGGGPSVPEPGAPACSGAPATSTASTPAAGASGGTSRPQNAPTPPALGPGPLLTSTPSLPSPLLPQTSASTVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASTEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPALPTVPTSVGLQLPPTLPGVGVGSYVDSPSLTPASRSPQRPSPASSECPSLSPGLTSSEAGVPVAAGSPQPAPGGSSLPKTEPVSLPCTNARVGDLPATAGQVSTTSALADSSASPGLCSPVLPAGAEPFKAKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDAVLPYDDKAADALSACDDDMDDNSLEDDAELKDAAGDPNKPLLAFSGSCPPSPPSVISSIAALENQMKMMDSVMSCPQLSALKSLENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSLQALSPGNSNSESLPSKSPGLGAQEEPQETPLKTEKPDSPLPGPENGGALDLTATHPCRPSVKEEAPFSLLFLSRDRGPSQGTPSLGPGSTPTTIKTEVNGHSKAGLLAEGPPLPAAVQVPPGPPTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGLPQLPVSLSGSALPPLGSLAAGLDKARPGSSPPIAGLDKANSDTGGSRPFTRFIEDNKEIGIN", "length": 1229, "header": "tr|A0A3Q1LS63-1|A0AAA9SNS6_BOVIN Computationally mapped isoform of Sal-like protein 3 OS=Bos taurus OX=9913 GN=SALL3 PE=3 SV=2 CANONICAL=A0AAA9SNS6-1" }, "locus": { "chromosome": "24", "start_pos": 1067276, "end_pos": 1062204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076469.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076469.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059862.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059862.2" } ] } }, { "isoform_ac": "A0A3Q1NGV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6/entry#A0A3Q1NGV0-1", "sequence": { "sequence": "MSRRKQAKPQHLKSDEELPPPDGAPEHAAPGEGTEDADSGNESRSGGEDTHVCEKCCAEFFKWADLLAHKEACTKNPLVLIVGEDEPAPPSEDFPEASPASSASERADSEAAEEAAAAAAAAPEGGEAVEARAPEREDEPMEVGAPADKGFQGPGAAHAGQPPPPPGPEPAPGAAYGMPSTNVTLETLLSTKVAVAQFSQTSRAAGAAGPGGGVAAAALPLILEQLVALQQQQVQQLQLIEQIRSQVALMSRPLPPSRPPLHPGPAAHPTLPLSAGTGPAATAQGPAAPPAAYEGPQHLAAPASTASTPHVAGGGPSVPEPGAPACSGAPATSTASTPAAGASGGTSRPQNAPTPPALGPGPLLTSTPSLPSPLLPQTSASTVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASTEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPALPTVPTSVGLQLPPTLPGVGVGSYVDSPSLTPASRSPQRPSPASSECPSLSPGLTSSEAGVPVAAGSPQPAPGGSSLPKTEPVSLPCTNARVGDLPATAGQVSTTSALADSSASPGLCSPVLPAGAEPFKAKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDAVLPYDDKAADALSACDDDMDDNSLEDDAELKDAAGDPNKPLLAFSGSCPPSPPSVISSIAALENQMKMMDSVMSCPQLSALKSLENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSLQALSPGNSNSESLPSKSPGLGAQEEPQETPLKTEKPDSPLPGPENGGALDLTATHPCRPSVKEEAPFSLLFLSRDRGPSQGTPSLGPGSTPTTIKTEVNGHSKAGLLAEGPPLPAAVQVPPGPPTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGLPQLPLLCGQWSLVWSVAQQLGTSHRQNKSP", "length": 1220, "header": "tr|A0A3Q1NGV0-1|A0AAA9SNS6_BOVIN Computationally mapped isoform of Sal-like protein 3 OS=Bos taurus OX=9913 GN=SALL3 PE=3 SV=2 CANONICAL=A0AAA9SNS6-1" }, "locus": { "chromosome": "24", "start_pos": 1079138, "end_pos": 1061503, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078862.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078862.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071085.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071085.2" } ] } }, { "isoform_ac": "A0AAA9RTI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6/entry#A0AAA9RTI8-1", "sequence": { "sequence": "MLSELAKASLILLEMRKPDAAPGEGTEDADSGNESRSGGEDTHVCEKCCAEFFKWADLLAHKEACTKNPLVLIVGEDEPAPPSEDFPEASPASSASERADSEAAEEAAAAAAAAPEGGEAVEARAPEREDEPMEVGAPADKGFQGPGAAHAGQPPPPPGPEPAPGAAYGMPSTNVTLETLLSTKVAVAQFSQTSRAAGAAGPGGGVAAAALPLILEQLVALQQQQVQQLQLIEQIRSQVALMSRPLPPSRPPLHPGPAAHPTLPLSAGTGPAATAQGPAAPPAAYEGPQHLAAPASTASTPHVAGGGPSVPEPGAPACSGAPATSTASTPAAGASGGTSRPQNAPTPPALGPGPLLTSTPSLPSPLLPQTSASTVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASTEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPALPTVPTSVGLQLPPTLPGVGVGSYVDSPSLTPASRSPQRPSPASSECPSLSPGLTSSEAGVPVAAGSPQPAPGGSSLPKTEPVSLPCTNARVGDLPATAGQVSTTSALADSSASPGLCSPVLPAGAEPFKAKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDAVLPYDDKAADALSACDDDMDDNSLEDDAELKDAAGDPNKPLLAFSGSCPPSPPSVISSIAALENQMKMMDSVMSCPQLSALKSLENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSLQALSPGNSNSESLPSKSPGLGAQEEPQETPLKTEKPDSPLPGPENGGALDLTATHPCRPSVKEEAPFSLLFLSRDRGPSQGTPSLGPGSTPTTIKTEVNGHSKAGLLAEGPPLPAAVQVPPGPPTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGLPQLPVSLSGSALPPLGSLAAGLDKARPGSSPPIAGLDKANSDTGGSRPFTRFIEDNKEIGIN", "length": 1244, "header": "tr|A0AAA9RTI8-1|A0AAA9SNS6_BOVIN Computationally mapped isoform of Sal-like protein 3 OS=Bos taurus OX=9913 GN=SALL3 PE=3 SV=1 CANONICAL=A0AAA9SNS6-1" }, "locus": { "chromosome": "24", "start_pos": 1067553, "end_pos": 1062204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111049.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111049.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076299.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076299.1" } ] } }, { "isoform_ac": "A0AAA9SNS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6/entry#A0AAA9SNS6-1", "sequence": { "sequence": "MEASQQIHLLMFQQSMVFGDMDLRVRGAHTPLRTTTKGRLEAVTCLCPAAPGEGTEDADSGNESRSGGEDTHVCEKCCAEFFKWADLLAHKEACTKNPLVLIVGEDEPAPPSEDFPEASPASSASERADSEAAEEAAAAAAAAPEGGEAVEARAPEREDEPMEVGAPADKGFQGPGAAHAGQPPPPPGPEPAPGAAYGMPSTNVTLETLLSTKVAVAQFSQTSRAAGAAGPGGGVAAAALPLILEQLVALQQQQVQQLQLIEQIRSQVALMSRPLPPSRPPLHPGPAAHPTLPLSAGTGPAATAQGPAAPPAAYEGPQHLAAPASTASTPHVAGGGPSVPEPGAPACSGAPATSTASTPAAGASGGTSRPQNAPTPPALGPGPLLTSTPSLPSPLLPQTSASTVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASTEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPALPTVPTSVGLQLPPTLPGVGVGSYVDSPSLTPASRSPQRPSPASSECPSLSPGLTSSEAGVPVAAGSPQPAPGGSSLPKTEPVSLPCTNARVGDLPATAGQVSTTSALADSSASPGLCSPVLPAGAEPFKAKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDAVLPYDDKAADALSACDDDMDDNSLEDDAELKDAAGDPNKPLLAFSGSCPPSPPSVISSIAALENQMKMMDSVMSCPQLSALKSLENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSLQALSPGNSNSESLPSKSPGLGAQEEPQETPLKTEKPDSPLPGPENGGALDLTATHPCRPSVKEEAPFSLLFLSRDRGPSQGTPSLGPGSTPTTIKTEVNGHSKAGLLAEGPPLPAAVQVPPGPPTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGLPQLPVSLSGSALPPLGSLAAGLDKARPGSSPPIAGLDKANSDTGGSRPFTRFIEDNKEIGIN", "length": 1273, "header": "tr|A0AAA9SNS6-1|A0AAA9SNS6_BOVIN Isoform 1 of Sal-like protein 3 OS=Bos taurus OX=9913 GN=SALL3 PE=3 SV=1 CANONICAL=A0AAA9SNS6-1" }, "locus": { "chromosome": "24", "start_pos": 1068656, "end_pos": 1062204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090414.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090414.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085548.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085548.1" } ] } }, { "isoform_ac": "A0AAA9T578-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6/entry#A0AAA9T578-1", "sequence": { "sequence": "MSRRKQAKPQHLKSDEELPPPDGAPEHAAPGEGTEDADSGNESRSGGEDTHVCEKCCAEFFKWADLLAHKEACTKNPLVLIVGEDEPAPPSEDFPEASPASSASERADSEAAEEAAAAAAAAPEGGEAVEARAPEREDEPMEVGAPADKGFQGPGAAHAGQPPPPPGPEPAPGAAYGMPSTNVTLETLLSTKVAVAQFSQTSRAAGAAGPGGGVAAAALPLILEQLVALQQQQVQQLQLIEQIRSQVALMSRPLPPSRPPLHPGPAAHPTLPLSAGTGPAATAQGPAAPPAAYEGPQHLAAPASTASTPHVAGGGPSVPEPGAPACSGAPATSTASTPAAGASGGTSRPQNAPTPPALGPGPLLTSTPSLPSPLLPQTSASTVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASTEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPALPTVPTSVGLQLPPTLPGVGVGSYVDSPSLTPASRSPQRPSPASSECPSLSPGLTSSEAGVPVAAGSPQPAPGGSSLPKTEPVSLPCTNARVGDLPATAGQVSTTSALADSSASPGLCSPVLPAGAEPFKAKFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDAVLPYDDKAADALSACDDDMDDNSLEDDAELKDAAGDPNKPLLAFSGSCPPSPPSVISSIAALENQMKMMDSVMSCPQLSALKSLENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSLQALSPGNSNSESLPSKSPGLGAQEEPQETPLKTEKPDSPLPGPENGGALDLTATHPCRPSVKEEAPFSLLFLSRDRGPSQGTPSLGPGSTPTTIKTEVNGHSKAGLLAEGPPLPAAVQVPPGPPTVMSPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGLPQLPVSLSGSALPPLGSLAAGLDKARPGSSPPIAGLDKANSDTGGSRPFTRFIEDNKEIGIN", "length": 1252, "header": "tr|A0AAA9T578-1|A0AAA9T578_BOVIN Computationally mapped isoform of Sal-like protein 3 OS=Bos taurus OX=9913 GN=SALL3 PE=3 SV=1 CANONICAL=A0AAA9SNS6-1" }, "locus": { "chromosome": "24", "start_pos": 1079138, "end_pos": 1062204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101150.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101150.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090881.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1022, "start_aa": "Thr", "end_pos": 1022, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1022", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1030, "start_aa": "Thr", "end_pos": 1030, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1030", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 358, "start_aa": "Thr", "end_pos": 358, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr358", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" }, { "name": "limb morphogenesis", "id": "GO:0035108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" }, { "name": "olfactory bulb development", "id": "GO:0021772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021772", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 904, "end_pos": 906, "annotation": "n_glycosylation_sequon" }, { "start_pos": 914, "end_pos": 916, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 453, "end_pos": 480, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 358, 1022, 1030 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 904, "end_pos": 906 }, { "start_pos": 914, "end_pos": 916 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNA1-1", "uniprot_ac": "A0AAA9SNA1", "uniprot_id": "A0AAA9SNA1_BOVIN", "mass": { "chemical_mass": 126384.0, "monoisotopic_mass": 126384.0 }, "refseq": {}, "gene_names": [ { "name": "SLC12A7", "type": "recommended", "evidence": [ { "id": "A0AAA9SNA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SNA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1", "locus": { "chromosome": "20", "start_pos": 71300753, "end_pos": 71240463, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006775", "url": "https://www.ensembl.org/id/ENSBTAG00000006775" } ] } } ], "crossref": [ { "id": "A0AAA9SNA1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006775", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006775", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100337431", "url": "https://www.ncbi.nlm.nih.gov/gene/100337431", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-426117", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "72427", "url": "https://www.rhea-db.org/rhea/72427", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NIV4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N140", "url": "https://www.uniprot.org/uniprotkb/F1N140", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N140-1", "url": "https://www.uniprot.org/uniprotkb/F1N140-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCEDGGPPWEPRLAVCWGQPPGPGFMETLEGCAAVSVVCFVCVPCPLCSLHVTSTACPEAAGGKAEAPGRRASGALALPAACSPSWPGGCPRRCLPVSTSSCVATAPPDPGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPEWGNLNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1158, "header": "tr|A0AAA9SNA1-1|A0AAA9SNA1_BOVIN Isoform 1 of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=2 CANONICAL=A0AAA9SNA1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NIV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#A0A3Q1NIV4-1", "sequence": { "sequence": "MSQRFVVTPAAGGAGDAGPRPGGGGGQSCSSGRGPDADPAPSPEPPAVDALPILRYCREPSRYYGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1106, "header": "tr|A0A3Q1NIV4-1|A0AAA9SNA1_BOVIN Computationally mapped isoform of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=3 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71235578, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082311.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082311.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072000.3", "url": "https://www.ensembl.org/id/ENSBTAP00000072000.3" } ] } }, { "isoform_ac": "A0AAA9RRM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#A0AAA9RRM0-1", "sequence": { "sequence": "MSCEDGGPPWEPRLAVCWGQPPGPGFMETLEGCAAVSVVCFVCVPCPLCSLHVTSTACPEAAGGKAEAPGRRASGALALPAACSPSWPGGCPRRCLPVSTSSCVATAPPDPGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1153, "header": "tr|A0AAA9RRM0-1|A0AAA9SNA1_BOVIN Computationally mapped isoform of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=2 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71272461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116762.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116762.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074815.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074815.2" } ] } }, { "isoform_ac": "A0AAA9SE96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#A0AAA9SE96-1", "sequence": { "sequence": "MQGHRQRLLQTQHRLPPQVTAACGHGLGGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1070, "header": "tr|A0AAA9SE96-1|A0AAA9SNA1_BOVIN Computationally mapped isoform of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=1 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71260657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133656.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133656.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082157.1" } ] } }, { "isoform_ac": "A0AAA9SNA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#A0AAA9SNA1-1", "sequence": { "sequence": "MSCEDGGPPWEPRLAVCWGQPPGPGFMETLEGCAAVSVVCFVCVPCPLCSLHVTSTACPEAAGGKAEAPGRRASGALALPAACSPSWPGGCPRRCLPVSTSSCVATAPPDPGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPEWGNLNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1158, "header": "tr|A0AAA9SNA1-1|A0AAA9SNA1_BOVIN Isoform 1 of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=2 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71272461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104387.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104387.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085446.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085446.2" } ] } }, { "isoform_ac": "A0AAA9T8U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#A0AAA9T8U6-1", "sequence": { "sequence": "MGLQLEREDALASATAQASCEGFVLSELSQTQKGQLAGLSLCEAPEQPGLGDRKQRGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1098, "header": "tr|A0AAA9T8U6-1|A0AAA9T8U6_BOVIN Computationally mapped isoform of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=1 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71240662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092899.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092899.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094401.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094401.1" } ] } }, { "isoform_ac": "A0AAA9TXG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#A0AAA9TXG0-1", "sequence": { "sequence": "MPTNFTVVPVEARADGAQEEAAEPNEAPGPPEGGEPDCPSLGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1083, "header": "tr|A0AAA9TXG0-1|A0AAA9TXG0_BOVIN Computationally mapped isoform of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=1 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71262906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102150.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102150.1" } ] } }, { "isoform_ac": "F1N140-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1/entry#F1N140-1", "sequence": { "sequence": "MAAPPSTAARAVLGPEPAARSPGDGHPRESSPFISHGEADTESVYEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEAEDSRRRQAKSPGMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVSMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIVHPEGAGGEAAALLHNMRVYGTCTLALMATVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLSRRGFDVCAKVHTANNSSVTTALWSIFCNGSADSTSCDQYFLHNNVTEIQGIPGVASGVLLDNLWSMYADKGAFVEKKGVPSVAVPEEARARGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVILRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDSIVPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACALQTLLRTPSWRPRFKYYHWTLSFLGMSLCFALMFVCSWYYALCAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLHVEHGPLHTKNWRPQVLVLLNLDAEQRVKHPRLLSFTSQLKAGKGLTIVGSVLEGTFLDKHVEAQQAEENIRALMSAEKTKGFCQLVVSSSLRDGTSHLIQSAGLGAMKHNTVLVGWPGAWKREDNPCSWRNFVDTVRDTTAAQQALLVAKNVDLFPHNQQRLSGGHIDVWWIVHDGGLLMLLPFLLRQHKVWRRCQMRIFTVAQVDDNSIQMKKDLQTFLYHLRISAEVEVVEMVESDISAFTYERTLMMEQRSQMLKQMQLSKTEREREAQLIHDRNTASHSAMAARAQAPSTPDRVQMTWTKEKLVAEKHRNKDATVSGIKDLFNLKPNQSNVRRMHTAVRLNGVVLDKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGSGREVVTIYS", "length": 1064, "header": "tr|F1N140-1|A0AAA9SNA1_BOVIN Computationally mapped isoform of Solute carrier family 12 member 7 OS=Bos taurus OX=9913 GN=SLC12A7 PE=3 SV=4 CANONICAL=A0AAA9SNA1-1" }, "locus": { "chromosome": "20", "start_pos": 71299749, "end_pos": 71268179, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039197.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039197.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038997.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038997.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-426117", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "resource": "Reactome", "description": "Cation-coupled Chloride cotransporters" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "potassium ion homeostasis", "id": "GO:0055075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "potassium:chloride symporter activity", "id": "GO:0015379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015379", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1085, "end_pos": 1087, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72427", "name": "", "equation": "K(+)(in) + chloride(in) = K(+)(out) + chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72427" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 369, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA1" }, { "id": "PF03522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SLC12A transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 779, "end_pos": 896, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1085, "end_pos": 1087 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 414, "end_pos": 416 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 509, "end_pos": 511 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ90-1", "uniprot_ac": "A0AAA9SQ90", "uniprot_id": "A0AAA9SQ90_BOVIN", "mass": { "chemical_mass": 53659.0, "monoisotopic_mass": 53659.0 }, "refseq": {}, "gene_names": [ { "name": "MTHFD2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ] } ], "protein_names": [ { "name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTHFD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90", "locus": { "chromosome": "11", "start_pos": 10416222, "end_pos": 10465834, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004881", "url": "https://www.ensembl.org/id/ENSBTAG00000004881" } ] } } ], "crossref": [ { "id": "A0AAA9SQ90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ90", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004881", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004881", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01080", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01080", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI11", "url": "https://www.orthodb.org/?gene=A0A452DI11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48099:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48099:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02882", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02882", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196757", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196757", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "22892", "url": "https://www.rhea-db.org/rhea/22892", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "23700", "url": "https://www.rhea-db.org/rhea/23700", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI11", "url": "https://www.uniprot.org/uniprotkb/A0A452DI11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI11-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S388", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S388", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S388-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S388-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAGRRRGLPRCSGITVRPARASFPELTMAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVAKHTEELYKKELHNPDNHHGVITHLEPDILEGEVKWALGSITTNKASGGDGIPVELFQILKDDAVKVLHSICQQIWKTQQWPQDWKRSVFIPIPKKGNAKECSNYRTIALSHTLVK", "length": 491, "header": "tr|A0AAA9SQ90-1|A0AAA9SQ90_BOVIN Isoform 1 of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=1 CANONICAL=A0AAA9SQ90-1" }, "isoforms": [ { "isoform_ac": "A0A452DI11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#A0A452DI11-1", "sequence": { "sequence": "MAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVASN", "length": 314, "header": "tr|A0A452DI11-1|A0AAA9SQ90_BOVIN Computationally mapped isoform of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=2 CANONICAL=A0AAA9SQ90-1" }, "locus": { "chromosome": "11", "start_pos": 10446253, "end_pos": 10424989, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006419.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006419.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006419.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006419.7" } ] } }, { "isoform_ac": "A0AAA9S388-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#A0AAA9S388-1", "sequence": { "sequence": "MAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEELKKHTALADIVISAAGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVASN", "length": 267, "header": "tr|A0AAA9S388-1|A0AAA9SQ90_BOVIN Computationally mapped isoform of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=1 CANONICAL=A0AAA9SQ90-1" }, "locus": { "chromosome": "11", "start_pos": 10446253, "end_pos": 10424989, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131707.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131707.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080391.1" } ] } }, { "isoform_ac": "A0AAA9SE33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#A0AAA9SE33-1", "sequence": { "sequence": "MAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVASN", "length": 222, "header": "tr|A0AAA9SE33-1|A0AAA9SQ90_BOVIN Computationally mapped isoform of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=1 CANONICAL=A0AAA9SQ90-1" }, "locus": { "chromosome": "11", "start_pos": 10446253, "end_pos": 10424989, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109544.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109544.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081848.1" } ] } }, { "isoform_ac": "A0AAA9SL07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#A0AAA9SL07-1", "sequence": { "sequence": "MPTSRQSSGPRLRTCISYVSYFGRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVAKHTEELYKKELHNPDNHHGVITHLEPDILEGEVKWALGSITTNKASGGDGIPVELFQILKDDAVKVLHSICQQIWKTQQWPQDWKRSVFIPIPKKGNAKECSNYRTIALSHTLVK", "length": 453, "header": "tr|A0AAA9SL07-1|A0AAA9SQ90_BOVIN Computationally mapped isoform of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=1 CANONICAL=A0AAA9SQ90-1" }, "locus": { "chromosome": "11", "start_pos": 10450262, "end_pos": 10417905, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130492.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130492.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084583.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084583.1" } ] } }, { "isoform_ac": "A0AAA9SQ90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#A0AAA9SQ90-1", "sequence": { "sequence": "MGAGRRRGLPRCSGITVRPARASFPELTMAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVAKHTEELYKKELHNPDNHHGVITHLEPDILEGEVKWALGSITTNKASGGDGIPVELFQILKDDAVKVLHSICQQIWKTQQWPQDWKRSVFIPIPKKGNAKECSNYRTIALSHTLVK", "length": 491, "header": "tr|A0AAA9SQ90-1|A0AAA9SQ90_BOVIN Isoform 1 of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=1 CANONICAL=A0AAA9SQ90-1" }, "locus": { "chromosome": "11", "start_pos": 10446337, "end_pos": 10417905, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091729.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091729.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087536.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087536.1" } ] } }, { "isoform_ac": "A0AAA9TBR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90/entry#A0AAA9TBR4-1", "sequence": { "sequence": "MGAGRRRGLPRCSGITVRPARASFPELTMAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEWVASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEELKKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGTPEWVAVSSSRGSSDPEIELKSPVLPALQADSLPLSHRGSP", "length": 366, "header": "tr|A0AAA9TBR4-1|A0AAA9TBR4_BOVIN Computationally mapped isoform of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus OX=9913 GN=MTHFD2 PE=3 SV=1 CANONICAL=A0AAA9SQ90-1" }, "locus": { "chromosome": "11", "start_pos": 10446337, "end_pos": 10425438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117882.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117882.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093525.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093525.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-196757", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196757", "resource": "Reactome", "description": "Metabolism of folate and pterines" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "methenyltetrahydrofolate cyclohydrolase activity", "id": "GO:0004477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "id": "GO:0004488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004488", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "methylenetetrahydrofolate dehydrogenase (NAD+) activity", "id": "GO:0004487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004487", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "phosphate ion binding", "id": "GO:0042301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "tetrahydrofolate interconversion", "id": "GO:0035999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035999", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "one-carbon metabolic process", "id": "GO:0006730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "folic acid-containing compound metabolic process", "id": "GO:0006760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "carboxylic acid metabolic process", "id": "GO:0019752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019752", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" }, { "name": "formate biosynthetic process", "id": "GO:0015943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015943", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22892", "name": "", "equation": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5C2-1", "A0AAA9SQ90-1", "E1BNJ2-1" ], "evidence": [ { "id": "22892", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22892" } ] }, { "id": "23700", "name": "", "equation": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SQ90-1", "E1BNJ2-1", "Q0P5C2-1" ], "evidence": [ { "id": "23700", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23700" } ] }, { "id": "R-BTA-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SQ90-1" ], "evidence": [ { "id": "R-BTA-6801328", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6801328" } ] }, { "id": "R-BTA-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-6801458" ], "output_participant_list": [], "enzyme_list": [ "A0AAA9SQ90-1" ], "evidence": [ { "id": "R-BTA-6801462", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6801462" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6801458", "participant_name": "5,10-methenyl-THF [mitochondrial matrix]", "crossref": [ { "id": "57455", "database": "ChEBI", "url": "" }, { "id": "ZINC000004228270", "database": "ZINC", "url": "" }, { "id": "HMDB0062623", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SQ90", "gene_name": "MTHFD2", "activity": [ { "ec_number": "3.5.4.9", "activity": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+).", "evidence": [ { "id": "A0AAA9SQ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ] }, { "ec_number": "3.5.4.9", "activity": "", "evidence": [ { "id": "A0AAA9SQ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" } ] } ] }, { "uniprot_ac": "E1BNJ2", "gene_name": "MTHFD2L", "activity": [ { "ec_number": "3.5.4.9", "activity": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+).", "evidence": [ { "id": "E1BNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNJ2" } ] }, { "ec_number": "3.5.4.9", "activity": "", "evidence": [ { "id": "E1BNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNJ2" } ] } ] }, { "uniprot_ac": "Q0P5C2", "gene_name": "MTHFD2", "activity": [ { "ec_number": "3.5.4.9", "activity": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+).", "evidence": [ { "id": "Q0P5C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5C2" } ] }, { "ec_number": "1.5.1.15", "activity": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH.", "evidence": [ { "id": "Q0P5C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5C2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" }, { "id": "PF02882", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02882" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding", "eco_id": "ECO_0000259", "start_pos": 202, "end_pos": 358, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ90" }, { "id": "PF00763", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00763" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 183, "start_aa": "Ile", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.4.9", "ec_name": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+).", "evidence": [ { "id": "3.5.4.9", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9" }, { "id": "3.5.4.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.4.9" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQD9-1", "uniprot_ac": "A0AAA9SQD9", "uniprot_id": "A0AAA9SQD9_BOVIN", "mass": { "chemical_mass": 22112.0, "monoisotopic_mass": 22112.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Securin", "type": "recommended", "evidence": [ { "id": "A0AAA9SQD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SQD9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012184", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012184", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NHICLAG", "url": "https://omabrowser.org/oma/group/NHICLAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIH5", "url": "https://www.orthodb.org/?gene=A0A452DIH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10418", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10418", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10418:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10418:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A452DIH5", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIH5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTLIYVDKENGEPGIHVAPKDGLKLGSVPFKALDGRSQVSTPRVGKMFDAPPALPKTARKALGTVNRATEKSVKTNGPLKQKQTTFSTKKITEKTVKAKSSVPASDDTYPEIEKFFPFNPLDFENFDLPEEHQIARLPLSGVPLMILDEERELEQLLHVGPPSPLKMPPLLWESNLLQSPSSILSTLDVELPPVCCDLDI", "length": 201, "header": "tr|A0AAA9SQD9-1|A0AAA9SQD9_BOVIN Isoform 1 of Securin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SQD9-1" }, "isoforms": [ { "isoform_ac": "A0A452DIH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9/entry#A0A452DIH5-1", "sequence": { "sequence": "MSTLIYVDKENGEPGIHVAPKDGLKLGSVPSVKALDGRSQVSTPRVGKMFDAPPALPKTARKALGTVNRATEKSVKTNGPLKQKQTTFSTKKITEKTVKAKSSVPASDDTYPEIEKFFPFNPLDFENFDLPEEHQIARLPLSGVPLMILDEERELEQLLHVGPPSPLKMPPLLWESNLLQSPSSILSTLDVELPPVCCDLDI", "length": 202, "header": "tr|A0A452DIH5-1|A0AAA9SQD9_BOVIN Computationally mapped isoform of Securin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SQD9-1" }, "locus": { "chromosome": "7", "start_pos": 72013509, "end_pos": 72006440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016162.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016162.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016162.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016162.3" } ] } }, { "isoform_ac": "A0AAA9RWT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9/entry#A0AAA9RWT3-1", "sequence": { "sequence": "MDSVARQALLSMEFSRQEYWSGSPCPSPGYLPDPGIEPESLKSPVLPAVKALDGRSQVSTPRVGKMFDAPPALPKTARKALGTVNRATEKSVKTNGPLKQKQTTFSTKKITEKTVKAKSSVPASDDTYPEIEKFFPFNPLDFENFDLPEEHQIARLPLSGVPLMILDEERELEQLLHVGPPSPLKMPPLLWESNLLQSPSSILSTLDVELPPVCCDLDI", "length": 219, "header": "tr|A0AAA9RWT3-1|A0AAA9SQD9_BOVIN Computationally mapped isoform of Securin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SQD9-1" }, "locus": { "chromosome": "7", "start_pos": 72013509, "end_pos": 72006681, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130978.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130978.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077920.1" } ] } }, { "isoform_ac": "A0AAA9SQD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9/entry#A0AAA9SQD9-1", "sequence": { "sequence": "MSTLIYVDKENGEPGIHVAPKDGLKLGSVPFKALDGRSQVSTPRVGKMFDAPPALPKTARKALGTVNRATEKSVKTNGPLKQKQTTFSTKKITEKTVKAKSSVPASDDTYPEIEKFFPFNPLDFENFDLPEEHQIARLPLSGVPLMILDEERELEQLLHVGPPSPLKMPPLLWESNLLQSPSSILSTLDVELPPVCCDLDI", "length": 201, "header": "tr|A0AAA9SQD9-1|A0AAA9SQD9_BOVIN Isoform 1 of Securin OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SQD9-1" }, "locus": { "chromosome": "7", "start_pos": 72013509, "end_pos": 72006440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100515.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100515.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085156.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085156.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "homologous chromosome segregation", "id": "GO:0045143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045143", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" }, { "name": "chromosome organization", "id": "GO:0051276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPZ1-1", "uniprot_ac": "A0AAA9SPZ1", "uniprot_id": "A0AAA9SPZ1_BOVIN", "mass": { "chemical_mass": 29752.0, "monoisotopic_mass": 29752.0 }, "refseq": {}, "gene_names": [ { "name": "NUDT13", "type": "recommended", "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ] } ], "protein_names": [ { "name": "Nudix hydrolase 13", "type": "synonym", "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUDT13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1", "locus": { "chromosome": "28", "start_pos": 29206547, "end_pos": 29189820, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000313", "url": "https://www.ensembl.org/id/ENSBTAG00000000313" } ] } } ], "crossref": [ { "id": "A0AAA9SPZ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03429", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03429", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11383:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11383:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00293", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00293", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09296", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09296", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "11800", "url": "https://www.rhea-db.org/rhea/11800", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48868", "url": "https://www.rhea-db.org/rhea/48868", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60820", "url": "https://www.rhea-db.org/rhea/60820", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6K8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6K8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLYCGTACRRKIFWCYRLLSTYVTKTRYLCELKEDDDACKKAQQTGAFYLFHNLAPLLQKSEHQYLAPQHSLLELERLLSKFGQDSQILEDSVLIGCSEEQEAWFALDLGLNSSSSINASLQKAEIETALQGSFIKLTKALFELNVKDASLLSTAQALLRWHDAHQFCSRSGQPTKKNVSGSKRVCPSNNIIYYPQLQVNLRELEAAAWFSRDEVATVLRRNNPSNQQQSGAVPFWLPPKLAIAHQLIKEWVEKPTCSPLPA", "length": 263, "header": "tr|A0AAA9SPZ1-1|A0AAA9SPZ1_BOVIN Isoform 1 of Nudix hydrolase 13 OS=Bos taurus OX=9913 GN=NUDT13 PE=4 SV=1 CANONICAL=A0AAA9SPZ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1/entry#A0AAA9SFP9-1", "sequence": { "sequence": "MSLYCGTACRRKIFWCYRLLSTYVTKTRICQARILEWVAVSFSRGSSRSRDQTRIAYIAELERLLSKFGQDSQILEDSVLIGCSEEQEAWFALDLGLNSSSSINASLQKAEIETALQGSFIKLTKALFELNVKDASLLSTAQALLRWHDAHQFCSRSGQPTKKNVSGSKRVCPSNNIIYYPQVAPVVITLVSDGTRCLLVRQSSFPKGMYSALAGFCDIGESLEETVRREIAEEVGLEVDRLHYSASQHWPFPNSTLMIACHATVKPGQTELQVNLRELEAAAWFSRDEVATVLRRNNPSNQQQSGAVPFWLPPKLAIAHQLIKEWVEKPTCSPLPA", "length": 337, "header": "tr|A0AAA9SFP9-1|A0AAA9SPZ1_BOVIN Computationally mapped isoform of Nudix hydrolase 13 OS=Bos taurus OX=9913 GN=NUDT13 PE=4 SV=1 CANONICAL=A0AAA9SPZ1-1" }, "locus": { "chromosome": "28", "start_pos": 29205967, "end_pos": 29195424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120644.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120644.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085003.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085003.1" } ] } }, { "isoform_ac": "A0AAA9SPZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1/entry#A0AAA9SPZ1-1", "sequence": { "sequence": "MSLYCGTACRRKIFWCYRLLSTYVTKTRYLCELKEDDDACKKAQQTGAFYLFHNLAPLLQKSEHQYLAPQHSLLELERLLSKFGQDSQILEDSVLIGCSEEQEAWFALDLGLNSSSSINASLQKAEIETALQGSFIKLTKALFELNVKDASLLSTAQALLRWHDAHQFCSRSGQPTKKNVSGSKRVCPSNNIIYYPQLQVNLRELEAAAWFSRDEVATVLRRNNPSNQQQSGAVPFWLPPKLAIAHQLIKEWVEKPTCSPLPA", "length": 263, "header": "tr|A0AAA9SPZ1-1|A0AAA9SPZ1_BOVIN Isoform 1 of Nudix hydrolase 13 OS=Bos taurus OX=9913 GN=NUDT13 PE=4 SV=1 CANONICAL=A0AAA9SPZ1-1" }, "locus": { "chromosome": "28", "start_pos": 29205967, "end_pos": 29195424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122634.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122634.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084997.1" } ] } }, { "isoform_ac": "A0AAA9T6K8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1/entry#A0AAA9T6K8-1", "sequence": { "sequence": "MSLYCGTACRRKIFWCYRLLSTYVTKTRYLCELKEDDDACKKAQQTGAFYLFHNLAPLLQKSEHQYLAPQHSLLELERLLSKFGQDSQILEDSVLIGCSEEQEAWFALDLGLNSSSSINASLQKAEIETALQGSFIKLTKALFELNVKDASLLSTAQALLRWHDAHQFCSRSGQPTKKNVSGSKRVCPSNNIIYYPQVKVWKRLSGEKLQKRWDWRWTDCITLHPSIGPFLTAHS", "length": 235, "header": "tr|A0AAA9T6K8-1|A0AAA9T6K8_BOVIN Computationally mapped isoform of Nudix hydrolase 13 OS=Bos taurus OX=9913 GN=NUDT13 PE=4 SV=1 CANONICAL=A0AAA9SPZ1-1" }, "locus": { "chromosome": "28", "start_pos": 29204630, "end_pos": 29195424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115084.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115084.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091412.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091412.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11800", "name": "", "equation": "NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1", "A0AAA9SPZ1-1" ], "evidence": [ { "id": "11800", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11800" } ] }, { "id": "48868", "name": "", "equation": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1", "A0AAA9SPZ1-1", "F6R6Q1-1", "A0AAA9TEH3-1" ], "evidence": [ { "id": "48868", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48868" } ] }, { "id": "60820", "name": "", "equation": "NADPH + H2O = reduced beta-nicotinamide D-ribonucleotide + adenosine 2',5'-bisphosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZDK8-1", "Q29RH3-1", "A0AAA9SPZ1-1" ], "evidence": [ { "id": "60820", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60820" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SPZ1", "gene_name": "NUDT13", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ] }, { "ec_number": "3.6.1.22", "activity": "", "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" } ] } ] }, { "uniprot_ac": "A0AAA9TEH3", "gene_name": "NUDT6", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TEH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH3" } ] } ] }, { "uniprot_ac": "A0AAF6ZDK8", "gene_name": "NUDT12", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ] }, { "ec_number": "3.6.1.22", "activity": "", "evidence": [ { "id": "A0AAF6ZDK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDK8" } ] } ] }, { "uniprot_ac": "F6R6Q1", "gene_name": "FLAD1", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "2.7.7.2", "activity": "FMN + ATP + H(+) = FAD + diphosphate.", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "3.6.1.18", "activity": "FAD + H2O = FMN + AMP + 2 H(+).", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "3.6.1.22", "activity": "", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "2.7.7.2", "activity": "", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] }, { "ec_number": "3.6.1.18", "activity": "", "evidence": [ { "id": "F6R6Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6Q1" } ] } ] }, { "uniprot_ac": "Q29RH3", "gene_name": "NUDT12", "activity": [ { "ec_number": "3.6.1.22", "activity": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "Q29RH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH3" } ] }, { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q29RH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RH3" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" }, { "id": "PF09296", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09296" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADH pyrophosphatase-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 162, "start_aa": "Ala", "end_aa": "Trp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SPZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ1" }, { "id": "PF09297", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09297" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Zinc ribbon NADH pyrophosphatase", "eco_id": "ECO_0000259", "start_pos": 165, "end_pos": 195, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.22", "ec_name": "NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+).", "evidence": [ { "id": "3.6.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22" }, { "id": "3.6.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 119, "end_pos": 121 }, { "start_pos": 179, "end_pos": 181 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR48-1", "uniprot_ac": "A0AAA9SR48", "uniprot_id": "A0AAA9SR48_BOVIN", "mass": { "chemical_mass": 41069.0, "monoisotopic_mass": 41069.0 }, "refseq": {}, "gene_names": [ { "name": "EFCAB11", "type": "recommended", "evidence": [ { "id": "A0AAA9SR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" } ] } ], "protein_names": [ { "name": "EF-hand calcium binding domain 11", "type": "synonym", "evidence": [ { "id": "A0AAA9SR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48", "locus": { "chromosome": "10", "start_pos": 101465633, "end_pos": 101634880, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013136", "url": "https://www.ensembl.org/id/ENSBTAG00000013136" } ] } } ], "crossref": [ { "id": "A0AAA9SR48", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR48", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013136", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013136", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617365", "url": "https://www.ncbi.nlm.nih.gov/gene/617365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YAMKHGQ", "url": "https://omabrowser.org/oma/group/YAMKHGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LG75", "url": "https://www.orthodb.org/?gene=A0A3Q1LG75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MA16", "url": "https://www.orthodb.org/?gene=A0A3Q1MA16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEF7", "url": "https://www.orthodb.org/?gene=A0A3Q1MEF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLI4", "url": "https://www.orthodb.org/?gene=A0A3Q1MLI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIY4", "url": "https://www.orthodb.org/?gene=E1BIY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LG75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LG75-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA16", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA16-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEF7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEF7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Q3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIY4", "url": "https://www.uniprot.org/uniprotkb/E1BIY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIY4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRMKNDTVPGPALCCRSVAQSCPTLCNPMDCSTPGFRVLHYLLELVKLMPIELVMPSNHLILCCPLLLLPSIFPSIRVFSNEPSLHMRWPEYWSFSISPSNEYSGLISFRMDWLDLLAVQGTLKNLLQHHGWRSINSLALSLLYGPTLTSIHDYWKNHSFDYVTSAK", "length": 356, "header": "tr|A0AAA9SR48-1|A0AAA9SR48_BOVIN Isoform 1 of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LG75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0A3Q1LG75-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRENEGDGICLADYGHSVTQCKPHAWHRAQHITGAQ", "length": 225, "header": "tr|A0A3Q1LG75-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=2 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101536624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087419.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087419.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057375.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057375.2" } ] } }, { "isoform_ac": "A0A3Q1MA16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0A3Q1MA16-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRLMSVPESQQFDFSESCVFLPSPSSFLLFLL", "length": 221, "header": "tr|A0A3Q1MA16-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=2 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101584996, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069375.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069375.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065348.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065348.2" } ] } }, { "isoform_ac": "A0A3Q1MEF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0A3Q1MEF7-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFSAGLVSAVPRGA", "length": 202, "header": "tr|A0A3Q1MEF7-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101593834, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085490.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085490.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072543.1" } ] } }, { "isoform_ac": "A0A3Q1MLI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0A3Q1MLI4-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRTCRWGYPSWRVACHLLDFPCISQTAFRVHHCVNTDVVCQCDKDCSPEKITGLDSSPSLGLVFEMSV", "length": 257, "header": "tr|A0A3Q1MLI4-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=2 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101599646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086245.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086245.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072561.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072561.2" } ] } }, { "isoform_ac": "A0AAA9RT96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0AAA9RT96-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFSWELISGRLPSGDVFVVECQVR", "length": 212, "header": "tr|A0AAA9RT96-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101487559, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075030.1" } ] } }, { "isoform_ac": "A0AAA9RVC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0AAA9RVC7-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRTPRSRNSILPVAQAQSLGASRVPFFFSTSMVSTPARLHTSAFTQESALKSLLDLCVRQSCVQLYVTPWTVAQQALLSVGFSRQEYWSGSPFPSPGDLPDPESESPSPESLKWQADS", "length": 307, "header": "tr|A0AAA9RVC7-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101504733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090838.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090838.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076252.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076252.1" } ] } }, { "isoform_ac": "A0AAA9SR48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0AAA9SR48-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRMKNDTVPGPALCCRSVAQSCPTLCNPMDCSTPGFRVLHYLLELVKLMPIELVMPSNHLILCCPLLLLPSIFPSIRVFSNEPSLHMRWPEYWSFSISPSNEYSGLISFRMDWLDLLAVQGTLKNLLQHHGWRSINSLALSLLYGPTLTSIHDYWKNHSFDYVTSAK", "length": 356, "header": "tr|A0AAA9SR48-1|A0AAA9SR48_BOVIN Isoform 1 of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101596022, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087819.1" } ] } }, { "isoform_ac": "A0AAA9SVI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0AAA9SVI6-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFRGHRFDSSLGS", "length": 201, "header": "tr|A0AAA9SVI6-1|A0AAA9SVI6_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101606972, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111074.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111074.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087200.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087200.1" } ] } }, { "isoform_ac": "A0AAA9T1Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#A0AAA9T1Q3-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFREVDQDSDGHVSFKDFEYAMNSGQKQA", "length": 217, "header": "tr|A0AAA9T1Q3-1|A0AAA9T1Q3_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=1 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101466637, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090336.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090336.1" } ] } }, { "isoform_ac": "E1BIY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48/entry#E1BIY4-1", "sequence": { "sequence": "MPVARRLSNERRRWRCLAKLSFRDCAERGWRSRPGGFGRRARGFCSLDSRGAMAMFCSQAGARPRTWEASPPEHKKWVEVFKACDEDNKGYLSREDFKVAVVMLFGYKPSKIEADSVMSSVDPNTSGIRLKEFLDIVRKKKEAQLYRNEVRHIFTAFDRHYRGYLTLEDFKKAFKQVAPKLSERIILEVFSIRLFSSESVLRIRWPKYWSSSFSVSPSSEHSGLVSLGWTGWISVLSKEPSRVFSNTTVQRHQFSPLSLSGPTLTLIHDY", "length": 270, "header": "tr|E1BIY4-1|A0AAA9SR48_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 11 OS=Bos taurus OX=9913 GN=EFCAB11 PE=4 SV=4 CANONICAL=A0AAA9SR48-1" }, "locus": { "chromosome": "10", "start_pos": 101634681, "end_pos": 101604598, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017461.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017461.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017461.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017461.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SDA8-1", "protein_name": "EF-hand calcium-binding domain-containing protein 11", "gene_name": "EFCAB11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFLSQAGAQPRMWEASPSEHKKWVEVFKACDEDNKGYLSREDFKVAIVMLFGYKPSKIEADSVMSSVEPNTSGIVLKEFLSIVRKKKEAQVYWNEIRHIFTAFDRHYRGYLTLEDFKKAFRQVAPKLPERIILEVFREVDQDSDDHVSFKDFEYAMNYGQKAE", "length": 163 }, "evidence": [ { "id": "A0AAA9SR48", "url": "https://omabrowser.org/oma/group/A0AAA9SR48/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AXQ2-1", "protein_name": "EF-hand calcium-binding domain-containing protein 11", "gene_name": "Efcab11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFLSEAGARPRAGEISASERRKWVEVFKACDEDNKGYLSREDFKVAIVMLFGYKPSKIEADAVMSSANPDTSGVSLEGFLNVVQRKKEAQLYRNEIRHIFTAFDVHYRGFLTLEDFKRAFSQVAPKLPSRTVLEVFREADQDSDGHVSFRDFEYAMNHGKAK", "length": 162 }, "evidence": [ { "id": "A0AAA9SR48", "url": "https://omabrowser.org/oma/group/A0AAA9SR48/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BUY7-1", "protein_name": "EF-hand calcium-binding domain-containing protein 11", "gene_name": "EFCAB11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFFSEARARSRTWEASPSEHRKWVEVFKACDEDHKGYLSREDFKTAVVMLFGYKPSKIEVDSVMSSINPNTSGILLEGFLNIVRKKKEAQRYRNEVRHIFTAFDTYYRGFLTLEDFKKAFRQVAPKLPERTVLEVFREVDRDSDGHVSFRDFEYALNYGQKEA", "length": 163 }, "evidence": [ { "id": "A0AAA9SR48", "url": "https://omabrowser.org/oma/group/A0AAA9SR48/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D0E5-1", "protein_name": "EF-hand calcium-binding domain-containing protein 11", "gene_name": "Efcab11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFLSEAGARPRAGEASASERRKWVKVFKACDEDNKGYLSREDFKVAIVMLFGYKPSKIEADAVMSSVNPNTSGVSLEGFLSAVKRKKEARLYRNEIRQIFTAFDVHYRGFLTLEDFKRAFSRVAPKLPARTVLEVFREADQDSDGHVSFRDFEYAMNHGQSK", "length": 162 }, "evidence": [ { "id": "A0AAA9SR48", "url": "https://omabrowser.org/oma/group/A0AAA9SR48/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" } ], "pmid": "" }, { "name": "enzyme regulator activity", "id": "GO:0030234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030234", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SR48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR48" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 107, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 346, "end_pos": 348 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR09-1", "uniprot_ac": "A0AAA9SR09", "uniprot_id": "A0AAA9SR09_BOVIN", "mass": { "chemical_mass": 20601.0, "monoisotopic_mass": 20601.0 }, "refseq": {}, "gene_names": [ { "name": "CARD19", "type": "recommended", "evidence": [ { "id": "A0AAA9SR09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09" } ] } ], "protein_names": [ { "name": "Caspase recruitment domain-containing protein 19", "type": "recommended", "evidence": [ { "id": "A0AAA9SR09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09/entry#names_and_taxonomy" } ] }, { "name": "Bcl10-interacting CARD protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SR09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CARD19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09", "locus": { "chromosome": "8", "start_pos": 84497829, "end_pos": 84481914, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011202", "url": "https://www.ensembl.org/id/ENSBTAG00000011202" } ] } } ], "crossref": [ { "id": "A0AAA9SR09", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR09", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011202", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011202", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13785", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13785", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR34765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJI0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5E9", "url": "https://www.uniprot.org/uniprotkb/G5E5E9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5E9-1", "url": "https://www.uniprot.org/uniprotkb/G5E5E9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RSEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGLATGLALLIYCCPPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL", "length": 183, "header": "tr|A0AAA9SR09-1|A0AAA9SR09_BOVIN Isoform 1 of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=4 SV=2 CANONICAL=A0AAA9SR09-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09/entry#A0A3Q1LJI0-1", "sequence": { "sequence": "MAVSWCVGLNTSSLGCAGSCRSVFSASVSEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGNRLPLPFSLSPDPGLHLFLRPPCLPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL", "length": 212, "header": "tr|A0A3Q1LJI0-1|A0AAA9SR09_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=4 SV=1 CANONICAL=A0AAA9SR09-1" }, "locus": { "chromosome": "8", "start_pos": 84497202, "end_pos": 84493131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086201.1", "url": "https://www.ensembl.org/id/ENSBTAT00000086201.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056681.1" } ] } }, { "isoform_ac": "A0AAA9SHI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09/entry#A0AAA9SHI1-1", "sequence": { "sequence": "MTEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGQSSPRPGAEPCQMDRGPHLRPRLVTQCGMPAVAFLPC", "length": 168, "header": "tr|A0AAA9SHI1-1|A0AAA9SR09_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=4 SV=1 CANONICAL=A0AAA9SR09-1" }, "locus": { "chromosome": "8", "start_pos": 84496960, "end_pos": 84482143, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111561.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111561.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083186.1" } ] } }, { "isoform_ac": "A0AAA9SR09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09/entry#A0AAA9SR09-1", "sequence": { "sequence": "RSEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGLATGLALLIYCCPPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL", "length": 183, "header": "tr|A0AAA9SR09-1|A0AAA9SR09_BOVIN Isoform 1 of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=4 SV=2 CANONICAL=A0AAA9SR09-1" }, "locus": { "chromosome": "8", "start_pos": 84497202, "end_pos": 84484808, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125956.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125956.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086408.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086408.2" } ] } }, { "isoform_ac": "G5E5E9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09/entry#G5E5E9-1", "sequence": { "sequence": "QLCLPAHQPPILWVHQETDKLPHIEQTYCDRLVQDTPFLTSLGRLSEQQVDRIILQLNRYYPQILSNKDAEKFRNPKLSLRVRLCDLLGHLQRSGERDCQEFYRALYIHAQPLHSCLPSRHALQNSDCTELDSGNASCELSDRGPVAFLTCLGLATGLALLIYCCPPDPKVLPGARRVLGFSPVIIDRHVSRFLLAFLTDDLGGL", "length": 205, "header": "tr|G5E5E9-1|G5E5E9_BOVIN Computationally mapped isoform of Caspase recruitment domain-containing protein 19 OS=Bos taurus OX=9913 GN=CARD19 PE=4 SV=2 CANONICAL=A0AAA9SR09-1" }, "locus": { "chromosome": "8", "start_pos": 84497202, "end_pos": 84482147, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014878.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014878.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014878.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014878.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SN63-1", "uniprot_ac": "A0AAA9SN63", "uniprot_id": "A0AAA9SN63_BOVIN", "mass": { "chemical_mass": 69268.0, "monoisotopic_mass": 69268.0 }, "refseq": { "ac": "XP_024848135", "name": "voltage-gated potassium channel KCNC2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848135" }, "gene_names": [ { "name": "KCNC2", "type": "recommended", "evidence": [ { "id": "A0AAA9SN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ] }, { "name": "KCNC2", "type": "synonym", "evidence": [ { "id": "XP_024848135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848135" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily C member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63/entry#names_and_taxonomy" } ] }, { "name": "voltage-gated potassium channel KCNC2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024848135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848135" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63", "locus": { "chromosome": "5", "start_pos": 4446688, "end_pos": 4726712, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054123", "url": "https://www.ensembl.org/id/ENSBTAG00000054123" } ] } } ], "crossref": [ { "id": "A0AAA9SN63", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SN63", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054123", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054123", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18415", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18415", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539913", "url": "https://www.ncbi.nlm.nih.gov/gene/539913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539913", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539913", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJT4", "url": "https://www.orthodb.org/?gene=A0A3Q1LJT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF172", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF172", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848135", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848135", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKIESNERVILNVGGTRHETYRSTLKTLPGTRLALLAASETQGDPLQPPTPARSPPPRPPPRSPGPGGCLEGGARNCSARGGDHPAGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFEAPDLLGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTESVTNGTSVVPQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFVKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPSFCKTELNMACNSKQGDTCLGKDSRLLEHNRSVLSGDDSAGSEPPLSPPERLPIRRSSTRDKHRRGETCFLLTAGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL", "length": 629, "header": "tr|A0AAA9SN63-1|A0AAA9SN63_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily C member 2 OS=Bos taurus OX=9913 GN=KCNC2 PE=4 SV=1 CANONICAL=A0AAA9SN63-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63/entry#A0A3Q1LJT4-1", "sequence": { "sequence": "MGKIESNERVILNVGGTRHETYRSTLKTLPGTRLALLAASETQGDPLQPPTPARSPPPRPPPRSPGPGGCLEGGARNCSARGGDHPAGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFEAPDLLGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTESVTNGTSVVPQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFVKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPSFCKTELNMACNSKQGDTCLGKDSRLLEHNRSVLSGDDSAGSEPPLSPPERLPIRRSSTRDKHRRGETCFLLTAGDYTCASDGGIRKVLYRIYHGFLTAEKGTVEFSHTKDCSGNRLLLLNVP", "length": 620, "header": "tr|A0A3Q1LJT4-1|A0AAA9SN63_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily C member 2 OS=Bos taurus OX=9913 GN=KCNC2 PE=4 SV=2 CANONICAL=A0AAA9SN63-1" }, "locus": { "chromosome": "5", "start_pos": 4725343, "end_pos": 4490065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076133.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076133.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056829.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056829.2" } ] } }, { "isoform_ac": "A0AAA9SN63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63/entry#A0AAA9SN63-1", "sequence": { "sequence": "MGKIESNERVILNVGGTRHETYRSTLKTLPGTRLALLAASETQGDPLQPPTPARSPPPRPPPRSPGPGGCLEGGARNCSARGGDHPAGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFEAPDLLGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTESVTNGTSVVPQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFVKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPSFCKTELNMACNSKQGDTCLGKDSRLLEHNRSVLSGDDSAGSEPPLSPPERLPIRRSSTRDKHRRGETCFLLTAGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL", "length": 629, "header": "tr|A0AAA9SN63-1|A0AAA9SN63_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily C member 2 OS=Bos taurus OX=9913 GN=KCNC2 PE=4 SV=1 CANONICAL=A0AAA9SN63-1" }, "locus": { "chromosome": "5", "start_pos": 4725343, "end_pos": 4492056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105870.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105870.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084265.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084265.1" } ] } }, { "isoform_ac": "A0AAA9SYN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63/entry#A0AAA9SYN4-1", "sequence": { "sequence": "MGKIESNERVILNVGGTRHETYRSTLKTLPGTRLALLAASETQGDPLQPPTPARSPPPRPPPRSPGPGGCLEGGARNCSARGGDHPAGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFEAPDLLGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTESVTNGTSVVPQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFVKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPSFCKTELNMACNSKQGDTCLGKDSRLLEHNRSGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL", "length": 574, "header": "tr|A0AAA9SYN4-1|A0AAA9SYN4_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily C member 2 OS=Bos taurus OX=9913 GN=KCNC2 PE=4 SV=1 CANONICAL=A0AAA9SN63-1" }, "locus": { "chromosome": "5", "start_pos": 4725343, "end_pos": 4492056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127489.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127489.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088474.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088474.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539913", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539913", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "membrane hyperpolarization", "id": "GO:0060081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060081", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "regulation of action potential firing rate", "id": "GO:0099605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "neuronal cell body membrane", "id": "GO:0032809", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032809", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 527, "end_pos": 529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN63" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 150, "start_aa": "Glu", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 250, "end_pos": 252 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 527, "end_pos": 529 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ31-1", "uniprot_ac": "A0AAA9SQ31", "uniprot_id": "A0AAA9SQ31_BOVIN", "mass": { "chemical_mass": 34586.0, "monoisotopic_mass": 34586.0 }, "refseq": {}, "gene_names": [ { "name": "TXNL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" } ] } ], "protein_names": [ { "name": "Thioredoxin-like protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Active thioredoxin with a redox potential of about -250 mV.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1ME81", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME81#function" }, { "database": "UniProtKB", "id": "ARBA00057161", "url": "https://www.uniprot.org/uniprotkb/ARBA00057161#function" }, { "database": "UniProtKB", "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TXNL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31", "locus": { "chromosome": "24", "start_pos": 55937036, "end_pos": 55980913, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015731", "url": "https://www.ensembl.org/id/ENSBTAG00000015731" } ] } } ], "crossref": [ { "id": "A0AAA9SQ31", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ31", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015731", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015731", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02947", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02947", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509142", "url": "https://www.ncbi.nlm.nih.gov/gene/509142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PIFEMFP", "url": "https://omabrowser.org/oma/group/PIFEMFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKV8", "url": "https://www.orthodb.org/?gene=A0A3Q1LKV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ME81", "url": "https://www.orthodb.org/?gene=A0A3Q1ME81", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LKV8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKV8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME81", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME81-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRLEKKEKATKGTEDTGRPCCNQSYSSWIIA", "length": 309, "header": "tr|A0AAA9SQ31-1|A0AAA9SQ31_BOVIN Isoform 1 of Thioredoxin-like protein 1 OS=Bos taurus OX=9913 GN=TXNL1 PE=1 SV=1 CANONICAL=A0AAA9SQ31-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31/entry#A0A3Q1LKV8-1", "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTVVGKKGESH", "length": 254, "header": "tr|A0A3Q1LKV8-1|A0AAA9SQ31_BOVIN Computationally mapped isoform of Thioredoxin-like protein 1 OS=Bos taurus OX=9913 GN=TXNL1 PE=1 SV=1 CANONICAL=A0AAA9SQ31-1" }, "locus": { "chromosome": "24", "start_pos": 55980736, "end_pos": 55938104, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075103.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075103.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057102.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057102.1" } ] } }, { "isoform_ac": "A0A3Q1ME81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31/entry#A0A3Q1ME81-1", "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRRIHIGKLRVISL", "length": 292, "header": "tr|A0A3Q1ME81-1|A0AAA9SQ31_BOVIN Computationally mapped isoform of Thioredoxin-like protein 1 OS=Bos taurus OX=9913 GN=TXNL1 PE=1 SV=1 CANONICAL=A0AAA9SQ31-1" }, "locus": { "chromosome": "24", "start_pos": 55980736, "end_pos": 55939556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076849.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076849.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069300.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069300.1" } ] } }, { "isoform_ac": "A0AAA9SQ31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31/entry#A0AAA9SQ31-1", "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRLEKKEKATKGTEDTGRPCCNQSYSSWIIA", "length": 309, "header": "tr|A0AAA9SQ31-1|A0AAA9SQ31_BOVIN Isoform 1 of Thioredoxin-like protein 1 OS=Bos taurus OX=9913 GN=TXNL1 PE=1 SV=1 CANONICAL=A0AAA9SQ31-1" }, "locus": { "chromosome": "24", "start_pos": 55980736, "end_pos": 55938040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104815.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104815.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085037.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085037.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NUH1-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVGVKLIANDTEFQPELSAAGSRLAVVKFTMRGCGPCLRIAPAFNALSNKYPQATFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGNNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDSTYLESDCDEQLLITVAFSQPVKLYSMKLQGPDNGQGPKYIKIFINLPRSMDFEEAERSEPTQALELTPDDIKEDGIIQLRYVKFQNVNSVTLFVQSNHGDEETTRITYFTFIGTPVQATNMNDFKRVVGKKGESH", "length": 289 }, "evidence": [ { "id": "A0AAA9SQ31", "url": "https://omabrowser.org/oma/group/A0AAA9SQ31/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43396-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "TXNL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH", "length": 289 }, "evidence": [ { "id": "A0AAA9SQ31", "url": "https://omabrowser.org/oma/group/A0AAA9SQ31/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CDN6-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "Txnl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDADIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH", "length": 289 }, "evidence": [ { "id": "A0AAA9SQ31", "url": "https://omabrowser.org/oma/group/A0AAA9SQ31/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q920J4-1", "protein_name": "Thioredoxin-like protein 1", "gene_name": "Txnl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDLSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH", "length": 289 }, "evidence": [ { "id": "A0AAA9SQ31", "url": "https://omabrowser.org/oma/group/A0AAA9SQ31/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VRP3-1", "protein_name": "Thioredoxin-like", "gene_name": "Txl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVRVINDESHFQAELAQAGIQLVVVDFTASWCGPCKRIAPIFETFPTKYPKAIFLKVDVDKCQDTAAGQGVSAMPTFIFYRNRTKIDRVQGADVNGLEAKIQEHIGTSGGEEGGEDYGQGLMELNTFISKQECECLNEADDHNLKHALASAGGYLQSDCDEQLILSITFNQAVKIHSLKFKAPSHLGPKDVKLFINQPRTIDFDMAESMNSVQDLSLAQKELESGVPVNLRYVKFQNVQNIQIFVKNNQSGGDVTQIDYIGFIGSPIMTTKMNDFKRVAGKKGESH", "length": 287 }, "evidence": [ { "id": "A0AAA9SQ31", "url": "https://omabrowser.org/oma/group/A0AAA9SQ31/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "disulfide oxidoreductase activity", "id": "GO:0015036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ31" }, { "id": "PS51532", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51532" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PITH", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 285, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 139, "end_pos": 141 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRD9-1", "uniprot_ac": "A0AAA9SRD9", "uniprot_id": "A0AAA9SRD9_BOVIN", "mass": { "chemical_mass": 43242.0, "monoisotopic_mass": 43242.0 }, "refseq": { "ac": "XP_005212919", "name": "cytotoxic granule associated RNA binding protein TIA1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212919" }, "gene_names": [ { "name": "TIA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ] }, { "name": "TIA1", "type": "synonym", "evidence": [ { "id": "XP_005212919", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212919" } ] } ], "protein_names": [ { "name": "Cytotoxic granule associated RNA binding protein TIA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein TIA-1", "type": "synonym", "evidence": [ { "id": "A0AAA9SRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#names_and_taxonomy" } ] }, { "name": "T-cell-restricted intracellular antigen-1", "type": "synonym", "evidence": [ { "id": "A0AAA9SRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#names_and_taxonomy" } ] }, { "name": "cytotoxic granule associated RNA binding protein TIA1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005212919", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212919" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9", "locus": { "chromosome": "11", "start_pos": 68519570, "end_pos": 68554903, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019182", "url": "https://www.ensembl.org/id/ENSBTAG00000019182" } ] } } ], "crossref": [ { "id": "A0AAA9SRD9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019182", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019182", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12615", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12615", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12618", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12618", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12620", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12620", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538533", "url": "https://www.ncbi.nlm.nih.gov/gene/538533", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LP63", "url": "https://www.orthodb.org/?gene=A0A3Q1LP63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M885", "url": "https://www.orthodb.org/?gene=A0A3Q1M885", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212919", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212919", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP63", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP63-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M885", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M885", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M885-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M885-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVRTAGNDPYCFVEFYEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQAYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQPWNQQGFNQTQSSPPWMGPNYGVQPPPGQNGSMMPNQPAGYRVAGYETQ", "length": 388, "header": "tr|A0AAA9SRD9-1|A0AAA9SRD9_BOVIN Isoform 1 of Cytotoxic granule associated RNA binding protein TIA1 OS=Bos taurus OX=9913 GN=TIA1 PE=4 SV=1 CANONICAL=A0AAA9SRD9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#A0A3Q1LP63-1", "sequence": { "sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFYEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQAYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQPWNQQGFNSLTKDRSRVPCFGSVES", "length": 351, "header": "tr|A0A3Q1LP63-1|A0AAA9SRD9_BOVIN Computationally mapped isoform of Cytotoxic granule associated RNA binding protein TIA1 OS=Bos taurus OX=9913 GN=TIA1 PE=4 SV=2 CANONICAL=A0AAA9SRD9-1" }, "locus": { "chromosome": "11", "start_pos": 68554725, "end_pos": 68519591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067277.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067277.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058800.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058800.2" } ] } }, { "isoform_ac": "A0A3Q1M885-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#A0A3Q1M885-1", "sequence": { "sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFYEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRQTQSSPPWMGPNYGVQPPPGQNGSMMPNQPAGYRVAGYETQ", "length": 285, "header": "tr|A0A3Q1M885-1|A0AAA9SRD9_BOVIN Computationally mapped isoform of Cytotoxic granule associated RNA binding protein TIA1 OS=Bos taurus OX=9913 GN=TIA1 PE=4 SV=2 CANONICAL=A0AAA9SRD9-1" }, "locus": { "chromosome": "11", "start_pos": 68554725, "end_pos": 68524405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072585.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072585.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070098.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070098.2" } ] } }, { "isoform_ac": "A0AAA9SM81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#A0AAA9SM81-1", "sequence": { "sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVRTAGNDPYCFVEFYEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQAYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQPWNQQGFNQTQSSPPWMGPNYGVQPPPGQNGSMMPNQPAGYRVAGYETQ", "length": 377, "header": "tr|A0AAA9SM81-1|A0AAA9SRD9_BOVIN Computationally mapped isoform of Cytotoxic granule associated RNA binding protein TIA1 OS=Bos taurus OX=9913 GN=TIA1 PE=4 SV=2 CANONICAL=A0AAA9SRD9-1" }, "locus": { "chromosome": "11", "start_pos": 68554725, "end_pos": 68524405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130979.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130979.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087470.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087470.2" } ] } }, { "isoform_ac": "A0AAA9SRD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9/entry#A0AAA9SRD9-1", "sequence": { "sequence": "MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDVRTAGNDPYCFVEFYEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQAYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQPWNQQGFNQTQSSPPWMGPNYGVQPPPGQNGSMMPNQPAGYRVAGYETQ", "length": 388, "header": "tr|A0AAA9SRD9-1|A0AAA9SRD9_BOVIN Isoform 1 of Cytotoxic granule associated RNA binding protein TIA1 OS=Bos taurus OX=9913 GN=TIA1 PE=4 SV=1 CANONICAL=A0AAA9SRD9-1" }, "locus": { "chromosome": "11", "start_pos": 68554725, "end_pos": 68524405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094181.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094181.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086544.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086544.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear stress granule", "id": "GO:0097165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "protein-RNA adaptor activity", "id": "GO:0140517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "mRNA 3'-UTR AU-rich region binding", "id": "GO:0035925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "protein localization to cytoplasmic stress granule", "id": "GO:1903608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903608", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRD9" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 85, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 215, "end_pos": 217 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 369, "end_pos": 371 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNM2-1", "uniprot_ac": "A0AAA9SNM2", "uniprot_id": "A0AAA9SNM2_BOVIN", "mass": { "chemical_mass": 41877.0, "monoisotopic_mass": 41877.0 }, "refseq": { "ac": "XP_005220511", "name": "tetratricopeptide repeat protein 19, mitochondrial isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220511" }, "gene_names": [ { "name": "TTC19", "type": "recommended", "evidence": [ { "id": "A0AAA9SNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2" } ] }, { "name": "TTC19", "type": "synonym", "evidence": [ { "id": "XP_005220511", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220511" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 19, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2/entry#names_and_taxonomy" } ] }, { "name": "tetratricopeptide repeat protein 19, mitochondrial isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005220511", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220511" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2", "locus": { "chromosome": "19", "start_pos": 33443095, "end_pos": 33480354, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013270", "url": "https://www.ensembl.org/id/ENSBTAG00000013270" } ] } } ], "crossref": [ { "id": "A0AAA9SNM2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013270", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013270", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "789903", "url": "https://www.ncbi.nlm.nih.gov/gene/789903", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789903", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MEM9", "url": "https://www.orthodb.org/?gene=F1MEM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13143", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13143", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13143:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13143:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9865881", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865881", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005220511", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220511", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEM9", "url": "https://www.uniprot.org/uniprotkb/F1MEM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEM9-1", "url": "https://www.uniprot.org/uniprotkb/F1MEM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYSMVIQMPVAQLNEDALWARAFAARECGSLVTEHPLLVRGIKAQPQRPDPSSPASAALKQSLVHRALAWSSRPAAAEQERRGAGGAAAGDAEAEIIQLLKRAKFCIMKDEPEEAELILHDALHLAHKSHNTKAIAYTYDLMANLAFIRGQLENAEKLFKATMSYLLGGGMQQEDNAIIEISLKLATIYAAQSRQELALAGYEFCISTLEEKIERERELSEDVLSADDKANTQLLLGMCLDTYARYLLFSQQPSQAQRMYEKALRISEEILGERHPQTIVLLNDLATTLDTQGRTDEACVHAQRASDLARQVEHPELHVLLSNLAAVLTHRELYAQAEETYREALRQAELKRDEASVQHIREELAELARKSRPLS", "length": 375, "header": "tr|A0AAA9SNM2-1|A0AAA9SNM2_BOVIN Isoform 1 of Tetratricopeptide repeat protein 19, mitochondrial OS=Bos taurus OX=9913 GN=TTC19 PE=3 SV=2 CANONICAL=A0AAA9SNM2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2/entry#A0AAA9SNM2-1", "sequence": { "sequence": "MYSMVIQMPVAQLNEDALWARAFAARECGSLVTEHPLLVRGIKAQPQRPDPSSPASAALKQSLVHRALAWSSRPAAAEQERRGAGGAAAGDAEAEIIQLLKRAKFCIMKDEPEEAELILHDALHLAHKSHNTKAIAYTYDLMANLAFIRGQLENAEKLFKATMSYLLGGGMQQEDNAIIEISLKLATIYAAQSRQELALAGYEFCISTLEEKIERERELSEDVLSADDKANTQLLLGMCLDTYARYLLFSQQPSQAQRMYEKALRISEEILGERHPQTIVLLNDLATTLDTQGRTDEACVHAQRASDLARQVEHPELHVLLSNLAAVLTHRELYAQAEETYREALRQAELKRDEASVQHIREELAELARKSRPLS", "length": 375, "header": "tr|A0AAA9SNM2-1|A0AAA9SNM2_BOVIN Isoform 1 of Tetratricopeptide repeat protein 19, mitochondrial OS=Bos taurus OX=9913 GN=TTC19 PE=3 SV=2 CANONICAL=A0AAA9SNM2-1" }, "locus": { "chromosome": "19", "start_pos": 33472852, "end_pos": 33444099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121565.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121565.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085495.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085495.2" } ] } }, { "isoform_ac": "A0AAA9TAF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2/entry#A0AAA9TAF7-1", "sequence": { "sequence": "MYRLLAVGLARGLLRVAGRRGRCHPVCLLPGPPGARAPPCRGAPRGRGSGLVPLLAALAWSSRPAAAEQERRGAGGAAAGDAEAEIIQLLKRAKFCIMKDEPEEAELILHDALHLAHKSHNTKAIAYTYDLAEKLFKATMSYLLGGGMQQEDNAIIEISLKLATIYAAQSRQELALAGYEFCISTLEEKIERERELSEDVLSADDKANTQLLLGMCLDTYARYLLFSQQPSQAQRMYEKALRISEEILGERHPQTIVLLNDLATTLDTQGRTDEACVHAQRASDLARQVEHPELHVLLSNLAAVLTHRELYAQAEETYREALRQAELKRDEASVQHIREELAELARKSRPLS", "length": 352, "header": "tr|A0AAA9TAF7-1|A0AAA9TAF7_BOVIN Computationally mapped isoform of Tetratricopeptide repeat protein 19, mitochondrial OS=Bos taurus OX=9913 GN=TTC19 PE=3 SV=1 CANONICAL=A0AAA9SNM2-1" }, "locus": { "chromosome": "19", "start_pos": 33472260, "end_pos": 33444099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095679.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095679.1" } ] } }, { "isoform_ac": "F1MEM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2/entry#F1MEM9-1", "sequence": { "sequence": "MYRLLAVGLARGLLRVAGRRGRCHPVCLLPGPPGARAPPCRGAPRGRGSGLVPLLAALAWSSRPAAAEQERRGAGGAAAGDAEAEIIQLLKRAKFCIMKDEPEEAELILHDALHLAHKSHNTKAIAYTYDLMANLAFIRGQLENAEKLFKATMSYLLGGGMQQEDNAIIEISLKLATIYAAQSRQELALAGYEFCISTLEEKIERERELSEDVLSADDKANTQLLLGMCLDTYARYLLFSQQPSQAQRMYEKALRISEEILGERHPQTIVLLNDLATTLDTQGRTDEACVHAQRASDLARQVEHPELHVLLSNLAAVLTHRELYAQAEETYREALRQAELKRDEASVQHIREELAELARKSRPLS", "length": 365, "header": "tr|F1MEM9-1|A0AAA9SNM2_BOVIN Computationally mapped isoform of Tetratricopeptide repeat protein 19, mitochondrial OS=Bos taurus OX=9913 GN=TTC19 PE=3 SV=5 CANONICAL=A0AAA9SNM2-1" }, "locus": { "chromosome": "19", "start_pos": 33472260, "end_pos": 33444099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035038.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035038.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034918.7", "url": "https://www.ensembl.org/id/ENSBTAP00000034918.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789903", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789903", "resource": "KEGG Pathway" }, { "id": "R-BTA-9865881", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865881", "resource": "Reactome", "description": "Complex III assembly" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex III assembly", "id": "GO:0034551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034551", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2" } ], "pmid": "" }, { "name": "respiratory electron transport chain", "id": "GO:0022904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMW3-1", "uniprot_ac": "A0AAA9SMW3", "uniprot_id": "A0AAA9SMW3_BOVIN", "mass": { "chemical_mass": 70164.0, "monoisotopic_mass": 70164.0 }, "refseq": { "ac": "XP_005208467", "name": "zinc finger protein 93 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208467" }, "gene_names": [ { "name": "ZNF93", "type": "recommended", "evidence": [ { "id": "A0AAA9SMW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ] }, { "name": "ZNF93", "type": "synonym", "evidence": [ { "id": "XP_005208467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208467" } ] } ], "protein_names": [ { "name": "Zinc finger protein 354B", "type": "synonym", "evidence": [ { "id": "A0AAA9SMW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 93 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208467", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208467" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SMW3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017123", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017123", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510078", "url": "https://www.ncbi.nlm.nih.gov/gene/510078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510078", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24376", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24376", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24376:SF245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24376:SF245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005208467", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208467", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S0V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0V1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEQ1", "url": "https://www.uniprot.org/uniprotkb/F1MEQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEQ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEQREARSQVSVTFEDVAVLFTRDEWRKLAPSQRNLYQDVMLENYSNLVSLGLPFSKPEVISLLQQGEDPWKVEKESPGDSSLECKSSPKTTKATQTQDSSFSGLIRKTLKKDEPWNFISENPCIYEDRIKKQKDKSESLQIISVTHTKILTVERSHKNNDFGQNFSLKSVFVKQQRIAREKTPSKYEIQRNSLRQDSNVLNQSKIKTAEKRHKCNICEKAFIHKSSLRKHQKNHTGERLFQCDECLKAFNQSSALIQHQRTHTGEKPYICKECGKAFSHSASLYKHVKIHTVEKSYKCKECGKSFGRRSALFIHQKIHAQDNPHKYNPGRKASTCNLPGCQRIHPRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCGECGRAFSQSASLIQHERIHTGEKPYRCNECEKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHQRIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHHRIHTGEKPYRCLECGISFGQSAALLQHQRIHTGEKPFVCITCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDPFKVDLHV", "length": 611, "header": "tr|A0AAA9SMW3-1|A0AAA9SMW3_BOVIN Isoform 1 of Zinc finger protein 354B OS=Bos taurus OX=9913 GN=ZNF93 PE=3 SV=1 CANONICAL=A0AAA9SMW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3/entry#A0AAA9S0V1-1", "sequence": { "sequence": "LLETSPILKGNCSSKGYGCRTEGSKVSECKSSPKTTKATQTQDSSFSGLIRKTLKKDEPWNFISENPCIYEDRIKKQKDKSESLQIISVTHTKILTVERSHKNNDFGQNFSLKSVFVKQQRIAREKTPSKYEIQRNSLRQDSNVLNQSKIKTAEKRHKCNICEKAFIHKSSLRKHQKNHTGERLFQCDECLKAFNQSSALIQHQRTHTGEKPYICKECGKAFSHSASLYKHVKIHTVEKSYKCKECGKSFGRRSALFIHQKIHAQDNPHKYNPGRKASTCNLPGCQRIHPRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCGECGRAFSQSASLIQHERIHTGEKPYRCNECEKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHQRIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHHRIHTGEKPYRCLECGISFGQSAALLQHQRIHTGEKPFVCITCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDPFKVDLHV", "length": 553, "header": "tr|A0AAA9S0V1-1|A0AAA9SMW3_BOVIN Computationally mapped isoform of Zinc finger protein 354B OS=Bos taurus OX=9913 GN=ZNF93 PE=3 SV=2 CANONICAL=A0AAA9SMW3-1" }, "locus": { "chromosome": "7", "start_pos": 3531595, "end_pos": 3508052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103487.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103487.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077273.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077273.2" } ] } }, { "isoform_ac": "A0AAA9SI02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3/entry#A0AAA9SI02-1", "sequence": { "sequence": "MLENYSNLVSLGLPFSKPEVISLLQQGEDPWKVEKESPGDSSLECKSSPKTTKATQTQDSSFSGLIRKTLKKDEPWNFISENPCIYEDRIKKQKDKSESLQIISVTHTKILTVERSHKNNDFGQNFSLKSVFVKQQRIAREKTPSKYEIQRNSLRQDSNVLNQSKIKTAEKRHKCNICEKAFIHKSSLRKHQKNHTGERLFQCDECLKAFNQSSALIQHQRTHTGEKPYICKECGKAFSHSASLYKHVKIHTVEKSYKCKECGKSFGRRSALFIHQKIHAQDNPHKYNPGRKASTCNLPGCQRIHPRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCGECGRAFSQSASLIQHERIHTGEKPYRCNECEKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHQRIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHHRIHTGEKPYRCLECGISFGQSAALLQHQRIHTGEKPFVCITCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDPFKVDLHV", "length": 569, "header": "tr|A0AAA9SI02-1|A0AAA9SMW3_BOVIN Computationally mapped isoform of Zinc finger protein 354B OS=Bos taurus OX=9913 GN=ZNF93 PE=3 SV=2 CANONICAL=A0AAA9SMW3-1" }, "locus": { "chromosome": "7", "start_pos": 3531595, "end_pos": 3511314, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103900.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103900.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083516.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083516.2" } ] } }, { "isoform_ac": "A0AAA9SMW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3/entry#A0AAA9SMW3-1", "sequence": { "sequence": "MAAEQREARSQVSVTFEDVAVLFTRDEWRKLAPSQRNLYQDVMLENYSNLVSLGLPFSKPEVISLLQQGEDPWKVEKESPGDSSLECKSSPKTTKATQTQDSSFSGLIRKTLKKDEPWNFISENPCIYEDRIKKQKDKSESLQIISVTHTKILTVERSHKNNDFGQNFSLKSVFVKQQRIAREKTPSKYEIQRNSLRQDSNVLNQSKIKTAEKRHKCNICEKAFIHKSSLRKHQKNHTGERLFQCDECLKAFNQSSALIQHQRTHTGEKPYICKECGKAFSHSASLYKHVKIHTVEKSYKCKECGKSFGRRSALFIHQKIHAQDNPHKYNPGRKASTCNLPGCQRIHPRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCGECGRAFSQSASLIQHERIHTGEKPYRCNECEKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHQRIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHHRIHTGEKPYRCLECGISFGQSAALLQHQRIHTGEKPFVCITCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDPFKVDLHV", "length": 611, "header": "tr|A0AAA9SMW3-1|A0AAA9SMW3_BOVIN Isoform 1 of Zinc finger protein 354B OS=Bos taurus OX=9913 GN=ZNF93 PE=3 SV=1 CANONICAL=A0AAA9SMW3-1" }, "locus": { "chromosome": "7", "start_pos": 3531595, "end_pos": 3508101, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110211.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110211.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087692.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087692.1" } ] } }, { "isoform_ac": "A0AAA9TL33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3/entry#A0AAA9TL33-1", "sequence": { "sequence": "MLENYSNLVSLGLPFSKPEVISLLQQGEDPWKVEKESPGDSSLGDSHSLSPLCIICDDWLSNKVSKPSKLLDHRKTKHPAIKCKSLEFFKGGKKESEYEEQKQLLKATTSNVSALSIILRANCIAKECKSSPKTTKATQTQDSSFSGLIRKTLKKDEPWNFISENPCIYEDRIKKQKDKSESLQIISVTHTKILTVERSHKNNDFGQNFSLKSVFVKQQRIAREKTPSKYEIQRNSLRQDSNVLNQSKIKTAEKRHKCNICEKAFIHKSSLRKHQKNHTGERLFQCDECLKAFNQSSALIQHQRTHTGEKPYICKECGKAFSHSASLYKHVKIHTVEKSYKCKECGKSFGRRSALFIHQKIHAQDNPHKYNPGRKASTCNLPGCQRIHPRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCGECGRAFSQSASLIQHERIHTGEKPYRCNECEKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHQRIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHHRIHTGEKPYRCLECGISFGQSAALLQHQRIHTGEKPFVCITCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDPFKVDLHV", "length": 652, "header": "tr|A0AAA9TL33-1|A0AAA9TL33_BOVIN Computationally mapped isoform of Zinc finger protein 354B OS=Bos taurus OX=9913 GN=ZNF93 PE=3 SV=2 CANONICAL=A0AAA9SMW3-1" }, "locus": { "chromosome": "7", "start_pos": 3531595, "end_pos": 3511314, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112706.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112706.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096994.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096994.2" } ] } }, { "isoform_ac": "F1MEQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3/entry#F1MEQ1-1", "sequence": { "sequence": "MCSVASCGWNPGTTLPWLCGLGSDFWRLHPSSRETAHQKDMAAEQREARSQVSVTFEDVAVLFTRDEWRKLAPSQRNLYQDVMLENYSNLVSLGLPFSKPEVISLLQQGEDPWKVEKESPGDSSLECKSSPKTTKATQTQDSSFSGLIRKTLKKDEPWNFISENPCIYEDRIKKQKDKSESLQIISVTHTKILTVERSHKNNDFGQNFSLKSVFVKQQRIAREKTPSKYEIQRNSLRQDSNVLNQSKIKTAEKRHKCNICEKAFIHKSSLRKHQKNHTGERLFQCDECLKAFNQSSALIQHQRTHTGEKPYICKECGKAFSHSASLYKHVKIHTVEKSYKCKECGKSFGRRSALFIHQKIHAQDNPHKYNPGRKASTCNLPGCQRIHPRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCGECGRAFSQSASLIQHERIHTGEKPYRCNECEKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHQRIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHHRIHTGEKPYRCLECGISFGQSAALLQHQRIHTGEKPFVCITCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDPFKVDLHV", "length": 651, "header": "tr|F1MEQ1-1|A0AAA9SMW3_BOVIN Computationally mapped isoform of Zinc finger protein 354B OS=Bos taurus OX=9913 GN=ZNF93 PE=3 SV=4 CANONICAL=A0AAA9SMW3-1" }, "locus": { "chromosome": "7", "start_pos": 3531595, "end_pos": 3507642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022760.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022760.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022760.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022760.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510078", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510078", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 215, "end_pos": 242, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW3" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 85, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 505, "end_pos": 507 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQN0-1", "uniprot_ac": "A0AAA9SQN0", "uniprot_id": "A0AAA9SQN0_BOVIN", "mass": { "chemical_mass": 33175.0, "monoisotopic_mass": 33175.0 }, "refseq": {}, "gene_names": [ { "name": "BTLA", "type": "recommended", "evidence": [ { "id": "A0AAA9SQN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ] } ], "protein_names": [ { "name": "B and T lymphocyte associated", "type": "synonym", "evidence": [ { "id": "A0AAA9SQN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTLA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0", "locus": { "chromosome": "1", "start_pos": 57228524, "end_pos": 57261711, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011871", "url": "https://www.ensembl.org/id/ENSBTAG00000011871" } ] } } ], "crossref": [ { "id": "A0AAA9SQN0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQN0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011871", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011871", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531767", "url": "https://www.ncbi.nlm.nih.gov/gene/531767", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531767", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531767", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NVTWCKF", "url": "https://omabrowser.org/oma/group/NVTWCKF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFY2", "url": "https://www.orthodb.org/?gene=F1MFY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37996", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37996", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37996:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37996:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFY2", "url": "https://www.uniprot.org/uniprotkb/F1MFY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFY2-1", "url": "https://www.uniprot.org/uniprotkb/F1MFY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKASLTVLGTGKLFWGFFLIPHVGIWSINGDKSCDIQLYIKKYSMYVVSSGDPFELECPMKYCADRPTVSWCKLEGNNCLHLGDRLQGSMGWEERKLISVFILHFNQVLASDSGSYRCFVNSSSGFIESHSITINVTDTKNASRPLSKEEMVDRQWILYSLLPLGALPLLITCFYLFCCLRRHRGRQKKLSNSTGRDTNLVDVPQFFRSEPTEIDIMESSQTLHLETGIYDNDPWFRVRRESGVYFNPSLEENKQGIIYASLKHSVIGMNPRQATHVQEAPTEYATICVRS", "length": 291, "header": "tr|A0AAA9SQN0-1|A0AAA9SQN0_BOVIN Isoform 1 of B and T lymphocyte associated OS=Bos taurus OX=9913 GN=BTLA PE=4 SV=1 CANONICAL=A0AAA9SQN0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0/entry#A0AAA9SQN0-1", "sequence": { "sequence": "MKASLTVLGTGKLFWGFFLIPHVGIWSINGDKSCDIQLYIKKYSMYVVSSGDPFELECPMKYCADRPTVSWCKLEGNNCLHLGDRLQGSMGWEERKLISVFILHFNQVLASDSGSYRCFVNSSSGFIESHSITINVTDTKNASRPLSKEEMVDRQWILYSLLPLGALPLLITCFYLFCCLRRHRGRQKKLSNSTGRDTNLVDVPQFFRSEPTEIDIMESSQTLHLETGIYDNDPWFRVRRESGVYFNPSLEENKQGIIYASLKHSVIGMNPRQATHVQEAPTEYATICVRS", "length": 291, "header": "tr|A0AAA9SQN0-1|A0AAA9SQN0_BOVIN Isoform 1 of B and T lymphocyte associated OS=Bos taurus OX=9913 GN=BTLA PE=4 SV=1 CANONICAL=A0AAA9SQN0-1" }, "locus": { "chromosome": "1", "start_pos": 57258152, "end_pos": 57229528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125419.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125419.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088643.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088643.1" } ] } }, { "isoform_ac": "A0AAA9TDR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0/entry#A0AAA9TDR5-1", "sequence": { "sequence": "MKASLTVLGTGKLFWGFFLIPHVGIWSINGDKSCDIQLYIKKYSMYVVSSGDPFELECPMKYCADRPTVSWCKLEGNNCLHLGDRLQGSMGWEERKLISVFILHFNQVLASDSGSYRCFVNSSSGFIESHSITINVTGRQKKLSNSTGRDTNLVDVPQFFRSEPTEIDIMESSQTLHLETGIYDNDPWFRVRRESGVYFNPSLEENKQGIIYASLKHSVIGMNPRQATHVQEAPTEYATICVRS", "length": 244, "header": "tr|A0AAA9TDR5-1|A0AAA9TDR5_BOVIN Computationally mapped isoform of B and T lymphocyte associated OS=Bos taurus OX=9913 GN=BTLA PE=4 SV=1 CANONICAL=A0AAA9SQN0-1" }, "locus": { "chromosome": "1", "start_pos": 57258152, "end_pos": 57229528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094293.1" } ] } }, { "isoform_ac": "F1MFY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0/entry#F1MFY2-1", "sequence": { "sequence": "MKASLTVLGTGKLFWGFFLIPHVGIWSINGDKSCDIQLYIKKYSMYVVSSGDPFELECPMKYCADRPTVSWCKLEGNNCLHLGDRLQGSMGWEERKLISVFILHFNQVLASDSGSYRCFVNSSSGFIESHSITINVTERTQNNSEHPLINTKNASRPLSKEEMVDRQWILYSLLPLGALPLLITCFYLFCCLRRHRGRQKKLSNSTGRDTNLVDVPQFFRSEPTEIDIMESSQTLHLETGIYDNDPWFRVRRESGVYFNPSLEENKQGIIYASLKHSVIGMNPRQATHVQEAPTEYATICVRS", "length": 303, "header": "tr|F1MFY2-1|A0AAA9SQN0_BOVIN Computationally mapped isoform of B and T lymphocyte associated OS=Bos taurus OX=9913 GN=BTLA PE=4 SV=3 CANONICAL=A0AAA9SQN0-1" }, "locus": { "chromosome": "1", "start_pos": 57258152, "end_pos": 57229528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015755.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015755.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015755.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015755.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531767", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531767", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6PNM1-1", "protein_name": "B- and T-lymphocyte attenuator", "gene_name": "Btla", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTVPAMLVTPRSFREFFILLLGLWSILCKEPTKRIGEECRVQLKIKRNSSRSAWTGELFKIECPVTYCVHRPNVTWCKHNGTRCVPLEVGPQLHTSWVENDQASAFVLYFEPIHLSDDGVYTCSANLNSEVINSHSVVIHVTERTQNCSEHPLITASDIPDATNASRPSTMEERPGRTWLLYALLPLGTSLLLLACVCLLCFLRRIQGKEKKPSDLAGRERETNLVDIPVSSRTNSQILTSETGIYDNDPWSSRLGESESTISSQLEGNKQGIVYASLNHCVIGRTPRQASKIQEAPTEYASICVRS", "length": 308 }, "evidence": [ { "id": "A0AAA9SQN0", "url": "https://omabrowser.org/oma/group/A0AAA9SQN0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TSA3-1", "protein_name": "B- and T-lymphocyte attenuator", "gene_name": "Btla", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTVPAMLGTPRLFREFFILHLGLWSILCEKATKRNDEECPVQLTITRNSKQSARTGELFKIQCPVKYCVHRPNVTWCKHNGTICVPLEVSPQLYTSWEENQSVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVRERTQNSSEHPLITVSDIPDATNASGPSTMEERPGRTWLLYTLLPLGALLLLLACVCLLCFLKRIQGKEKKPSDLAGRDTNLVDIPASSRTNHQALPSGTGIYDNDPWSSMQDESELTISLQSERNNQGIVYASLNHCVIGRNPRQENNMQEAPTEYASICVRS", "length": 306 }, "evidence": [ { "id": "A0AAA9SQN0", "url": "https://omabrowser.org/oma/group/A0AAA9SQN0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z6A9-1", "protein_name": "B- and T-lymphocyte attenuator", "gene_name": "BTLA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYRLLPLGGLPLLITTCFCLFCCLRRHQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGSEVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS", "length": 289 }, "evidence": [ { "id": "A0AAA9SQN0", "url": "https://omabrowser.org/oma/group/A0AAA9SQN0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of T cell proliferation", "id": "GO:0042130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042130", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "pmid": "" }, { "name": "regulation of ERK1 and ERK2 cascade", "id": "GO:0070372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070372", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "pmid": "" }, { "name": "immune response-regulating cell surface receptor signaling pathway", "id": "GO:0002768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "pmid": "" }, { "name": "regulation of T cell tolerance induction to tumor cell", "id": "GO:0002846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002846", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 133, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 135, "end_pos": 137 }, { "start_pos": 141, "end_pos": 143 }, { "start_pos": 192, "end_pos": 194 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SN41-1", "uniprot_ac": "A0AAA9SN41", "uniprot_id": "A0AAA9SN41_BOVIN", "mass": { "chemical_mass": 67829.0, "monoisotopic_mass": 67829.0 }, "refseq": {}, "gene_names": [ { "name": "FRMD7", "type": "recommended", "evidence": [ { "id": "A0AAA9SN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41" } ] } ], "protein_names": [ { "name": "FERM domain containing 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FRMD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41", "locus": { "chromosome": "X", "start_pos": 15980695, "end_pos": 16038866, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007344", "url": "https://www.ensembl.org/id/ENSBTAG00000007344" } ] } } ], "crossref": [ { "id": "A0AAA9SN41", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SN41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007344", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007344", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13193", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13193", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17188", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17188", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PYIPCTS", "url": "https://omabrowser.org/oma/group/PYIPCTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45858", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45858", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45858:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45858:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08736", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08736", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09379", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09379", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09380", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09380", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SN41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX99", "url": "https://www.uniprot.org/uniprotkb/F1MX99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX99-1", "url": "https://www.uniprot.org/uniprotkb/F1MX99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSHILQSELGDFHEETDRKHLAQTRYLPNQDDLESKIVHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLGYGSGYYRTVNGVHASEPVLDGRRRNSAVEVTFAAELEHSKPEADPTSLHQSQSSSSFPFIYTDPVFITDPDPDTDPRDYFEERGPLSSFQTSSKFADNPMSTSSGLTSKVSPARQLTYTDVPYIPCTGQQVDIMPPQVFFYVDRPPQVPRRSPIMAEERERPDSCLQSTAVKSAKRSPRNIRMKSFQQDFQELQEAMARTTGRSNVNVDLEEQDPTIEDTFAYNIQEPTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSRKADLLTYMFAEQEFPTVLMDQGATERYVPSESSDSESEILKPDYYSLYDKGIRSPMARIRLSSGSLQLDEEDEDVSFNTSTAEDRTLQKPCNYFLA", "length": 594, "header": "tr|A0AAA9SN41-1|A0AAA9SN41_BOVIN Isoform 1 of FERM domain containing 7 OS=Bos taurus OX=9913 GN=FRMD7 PE=4 SV=1 CANONICAL=A0AAA9SN41-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41/entry#A0AAA9SN41-1", "sequence": { "sequence": "MVSHILQSELGDFHEETDRKHLAQTRYLPNQDDLESKIVHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLGYGSGYYRTVNGVHASEPVLDGRRRNSAVEVTFAAELEHSKPEADPTSLHQSQSSSSFPFIYTDPVFITDPDPDTDPRDYFEERGPLSSFQTSSKFADNPMSTSSGLTSKVSPARQLTYTDVPYIPCTGQQVDIMPPQVFFYVDRPPQVPRRSPIMAEERERPDSCLQSTAVKSAKRSPRNIRMKSFQQDFQELQEAMARTTGRSNVNVDLEEQDPTIEDTFAYNIQEPTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSRKADLLTYMFAEQEFPTVLMDQGATERYVPSESSDSESEILKPDYYSLYDKGIRSPMARIRLSSGSLQLDEEDEDVSFNTSTAEDRTLQKPCNYFLA", "length": 594, "header": "tr|A0AAA9SN41-1|A0AAA9SN41_BOVIN Isoform 1 of FERM domain containing 7 OS=Bos taurus OX=9913 GN=FRMD7 PE=4 SV=1 CANONICAL=A0AAA9SN41-1" }, "locus": { "chromosome": "X", "start_pos": 15998884, "end_pos": 15981037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127816.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127816.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086739.1" } ] } }, { "isoform_ac": "F1MX99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41/entry#F1MX99-1", "sequence": { "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETDRKHLAQTRYLPNQDDLESKIVHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLGYGSGYYRTVNGVHASEPVLDGRRRNSAVEVTFAAELEHSKPEADPTSLHQSQSSSSFPFIYTDPVFITDPDPDTDPRDYFEERGPLSSFQTSSKFADNPMSTSSGLTSKVSPARQLTYTDVPYIPCTGQQVDIMPPQVFFYVDRPPQVPRRSPIMAEERERPDSCLQSTAVKSAKRSPRNIRMKSFQQDFQELQEAMARTTGRSNVNVDLEEQDPTIEDTFAYNIQEPTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSRKADLLTYMFAEQEFPTVLMDQGATERYVPSESSDSESEILKPDYYSLYDKGIRSPMARIRLSSGSLQLDEEDEDVSFNTSTAEDRTLQKPCNYFLA", "length": 714, "header": "tr|F1MX99-1|A0AAA9SN41_BOVIN Computationally mapped isoform of FERM domain containing 7 OS=Bos taurus OX=9913 GN=FRMD7 PE=4 SV=3 CANONICAL=A0AAA9SN41-1" }, "locus": { "chromosome": "X", "start_pos": 16038866, "end_pos": 15981037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009659.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009659.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009659.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009659.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A2AD83-1", "protein_name": "FERM domain-containing protein 7", "gene_name": "Frmd7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCGHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEVVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETVRKHLVQTQYLPSQASLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASESMLDSRRRNSAVEVTFAAELEHSKPEAEATSLHPSQSSSSFTFIYADPVFNTDPEPIEFFEERSPLSSFQTTSKFADSHTSKASPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLIMAEENMRPDSYVDHSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFACTFAEQEFPTVLIDQSSAERYVASESSDSESEIIKPDYYFLYGKGTKSPRARIRLSSGSLQLEEEDETISFATPGAEDRTLLKPCNYFLA", "length": 703 }, "evidence": [ { "id": "A0AAA9SN41", "url": "https://omabrowser.org/oma/group/A0AAA9SN41/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M1Y3-1", "protein_name": "FERM domain containing 7", "gene_name": "Frmd7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGWGWGDTSVLSIQTRGRLLEKTPFLSQHPQHSESAHSPTASLRMLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGHNVWLELLKPITKQVKNPKEVVFKFIVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEEMVRKHLVQTQYLPSQACLESKIMQFHQQHIGRSPAESDILLLDIARKLDMYGIRPQPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGKKGRLKSLPFERKQYPSQYHERQCRSSPDILSDVSKQVEDLRLTYGSSYYRNVNGVHASEPMLDGRRRNSAVEVTFAAELEHSKPEAEAASLHPSQSSSSFTFIYADPVFNTDPEPIDFFEERSPLSSFQTNSKFVDGHTSKVSPARQLTYTDVPYIPCTSQKVDIMPPQVFFYVDKPPQVPRRSLMMAEESMRPDSYVDPSAIKPAKRSPRNMRIKSLQQDLQELQEAMARTSGRSNINVEPEEEDPHLDDAFAYNLQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALTRKTDLFTCTFAEQEFPTVLMDQSSAERYVASESSDSESEILKTDYYSLYGKGTKSPRARIRLSSGSLQLEEEDEAISFGTPGAEDRTLLKPCNYFLA", "length": 748 }, "evidence": [ { "id": "A0AAA9SN41", "url": "https://omabrowser.org/oma/group/A0AAA9SN41/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZUT3-1", "protein_name": "FERM domain-containing protein 7", "gene_name": "FRMD7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKPDYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA", "length": 714 }, "evidence": [ { "id": "A0AAA9SN41", "url": "https://omabrowser.org/oma/group/A0AAA9SN41/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of neuron projection development", "id": "GO:0010975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SN41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN41" }, { "id": "PS50057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FERM", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 162, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 576, "end_pos": 578 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP94-1", "uniprot_ac": "A0AAA9SP94", "uniprot_id": "A0AAA9SP94_BOVIN", "mass": { "chemical_mass": 56097.0, "monoisotopic_mass": 56097.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM161A", "type": "recommended", "evidence": [ { "id": "A0AAA9SP94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ] } ], "protein_names": [ { "name": "Transmembrane protein 161A", "type": "recommended", "evidence": [ { "id": "A0AAA9SP94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM161A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94", "locus": { "chromosome": "7", "start_pos": 4120006, "end_pos": 4105828, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001817", "url": "https://www.ensembl.org/id/ENSBTAG00000001817" } ] } } ], "crossref": [ { "id": "A0AAA9SP94", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP94", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR019395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13624:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13624:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKDVGDRVSWVNSEAGSSAETQLAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPTEEELRALAGKQKPRGRKERWANGCSEEKPLSVPRDAPFQLQTCPLTAVDALVLRFFLEYQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTIAFSVKVFLTVTRLYFSAEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGLDSMSQNLEPLLKMQGWDWALPLVKLAIRVGLAVVGSMLGAFLTFPGLRLAQTHHDALTMSEDRPMLQFLLHTSFLSPLFVLWLWTKPMARDFLHQAPLGRMSFSLLSDSAFDSLRLWVLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREIQRRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPVPTLSPTPPSAHDGPVGPEEDEAQQTAALIAGALGSLLTPLFLRGVLAFLIWWIAACQLLSSLFGLYFHQHLAG", "length": 501, "header": "tr|A0AAA9SP94-1|A0AAA9SP94_BOVIN Isoform 1 of Transmembrane protein 161A OS=Bos taurus OX=9913 GN=TMEM161A PE=3 SV=1 CANONICAL=A0AAA9SP94-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94/entry#A0AAA9SP94-1", "sequence": { "sequence": "MEKDVGDRVSWVNSEAGSSAETQLAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPTEEELRALAGKQKPRGRKERWANGCSEEKPLSVPRDAPFQLQTCPLTAVDALVLRFFLEYQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTIAFSVKVFLTVTRLYFSAEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGLDSMSQNLEPLLKMQGWDWALPLVKLAIRVGLAVVGSMLGAFLTFPGLRLAQTHHDALTMSEDRPMLQFLLHTSFLSPLFVLWLWTKPMARDFLHQAPLGRMSFSLLSDSAFDSLRLWVLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREIQRRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPVPTLSPTPPSAHDGPVGPEEDEAQQTAALIAGALGSLLTPLFLRGVLAFLIWWIAACQLLSSLFGLYFHQHLAG", "length": 501, "header": "tr|A0AAA9SP94-1|A0AAA9SP94_BOVIN Isoform 1 of Transmembrane protein 161A OS=Bos taurus OX=9913 GN=TMEM161A PE=3 SV=1 CANONICAL=A0AAA9SP94-1" }, "locus": { "chromosome": "7", "start_pos": 4118421, "end_pos": 4109004, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121469.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121469.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084717.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084717.1" } ] } }, { "isoform_ac": "A0AAA9TJA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94/entry#A0AAA9TJA4-1", "sequence": { "sequence": "AVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPTEEELRALAGKQKPRGRKERWANGCSEEKPLSVPRDAPFQLQTCPLTAVDALVLRFFLEYQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTIAFSVKVFLTVTRLYFSAEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGACVRGLGRHRITSSCLDSMSQNLEPLLKMQGWDWALPLVKLAIRVGLAVVGSMLGAFLTFPGLRLAQTHHDALTMSEDRPMLQFLLHTSFLSPLFVLWLWTKPMARDFLHQAPLGRMSFSLLSDSAFDSLRLWVLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREIQRRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPVPTLSPTPPSAHDGPVGPEEDEAQQTAALIAGALGSLLTPLFLRGVLAFLIWWIAACQLLSSLFGLYFHQHLAG", "length": 492, "header": "tr|A0AAA9TJA4-1|A0AAA9SP94_BOVIN Computationally mapped isoform of Transmembrane protein 161A OS=Bos taurus OX=9913 GN=TMEM161A PE=3 SV=1 CANONICAL=A0AAA9SP94-1" }, "locus": { "chromosome": "7", "start_pos": 4118421, "end_pos": 4109517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102450.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102450.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097003.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097003.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 434, "start_aa": "Thr", "end_pos": 434, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr434", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:1902230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902230", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "pmid": "" }, { "name": "response to retinoic acid", "id": "GO:0032526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032526", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 434 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 410, "end_pos": 412 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQF4-1", "uniprot_ac": "A0AAA9SQF4", "uniprot_id": "A0AAA9SQF4_BOVIN", "mass": { "chemical_mass": 133949.0, "monoisotopic_mass": 133949.0 }, "refseq": {}, "gene_names": [ { "name": "SNX13", "type": "recommended", "evidence": [ { "id": "A0AAA9SQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ] } ], "protein_names": [ { "name": "Sorting nexin-13", "type": "recommended", "evidence": [ { "id": "A0AAA9SQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4", "locus": { "chromosome": "4", "start_pos": 26323655, "end_pos": 26469888, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014074", "url": "https://www.ensembl.org/id/ENSBTAG00000014074" } ] } } ], "crossref": [ { "id": "A0AAA9SQF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06873", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06873", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08719", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08719", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUS6", "url": "https://www.orthodb.org/?gene=A0A3Q1LUS6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22775", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22775", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22775:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22775:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LUS6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUS6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNW3", "url": "https://www.uniprot.org/uniprotkb/F1MNW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNW3-1", "url": "https://www.uniprot.org/uniprotkb/F1MNW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREGSFSPGPLPPYTRDARGPPRQPSEPRPPPLHPRADRPRRAAEDKQSPRGLAPAPGPAPRWGLSVLPAAPSQPLRPAAGPWPLALSWSSAARLRFPARRRYGDSHETPAAPAPANGSARRRETRTSLFQDGGASVASSRAGGKPAKPSKAAARERTEGAVAAVGGGSGSFRCCYGCCHAARLGRSSLPRGVIMLTETSLSIWGWGSLGIVLSLITFGPFVIFYLAFYILCFVGGGFVVTLLFGKTNSEKYLEQCEHSFLPPTSTGIPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRLVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKDVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGVLLPLINQLSDPDYINQYIIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLSSRQKDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNVNTEEMWKTYRRYSDFHDFHMRITEQFENLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIRQSFFKVPPLIPKTDSDPEHCRVSAQLDDTVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADLVKRFRDAFWPNGILAETIPCRDKGIRMRTRVAGKTKLLSIMPVLEKKMAPHSSTLAWKMPWMEEPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR", "length": 1174, "header": "tr|A0AAA9SQF4-1|A0AAA9SQF4_BOVIN Isoform 1 of Sorting nexin-13 OS=Bos taurus OX=9913 GN=SNX13 PE=3 SV=1 CANONICAL=A0AAA9SQF4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4/entry#A0A3Q1LUS6-1", "sequence": { "sequence": "MREGSFSPGPLPPYTRDARGPPRQPSEPRPPPLHPRADRPRRAAEDKQSPRGLAPAPGPAPRWGLSVLPAAPSQPLRPAAGPWPLALSWSSAARLRFPARRRYGDSHETPAAPAPANGSARRRETRTSLFQDGGASVASSRAGGKPAKPSKAAARERTEGAVAAVGGGSGSFRCCYGCCHAARLGRSSLPRGVIMLTETSLSIWGWGSLGIVLSLITFGPFVIFYLAFYILCFVGGGFVVTLLFGKTNSEKYLEQCEHSFLPPTSTGIPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRLVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKDVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGVLLPLINQLSDPDYINQYIIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLSSRQKDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTVYAHYDPYAVAGVCNDHGKTYALYAITVHRRNVNTEEMWKTYRRYSDFHDFHMRITEQFENLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIRQSFFKVPPLIPKTDSDPEHCRVSAQLDDTVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADLVKRFRDAFWPNGILAETIPCRDKGIRMRTRVAGKTKLLSIMPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR", "length": 1162, "header": "tr|A0A3Q1LUS6-1|A0AAA9SQF4_BOVIN Computationally mapped isoform of Sorting nexin-13 OS=Bos taurus OX=9913 GN=SNX13 PE=3 SV=2 CANONICAL=A0AAA9SQF4-1" }, "locus": { "chromosome": "4", "start_pos": 26469689, "end_pos": 26324659, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079788.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079788.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061108.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061108.2" } ] } }, { "isoform_ac": "A0AAA9SQF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4/entry#A0AAA9SQF4-1", "sequence": { "sequence": "MREGSFSPGPLPPYTRDARGPPRQPSEPRPPPLHPRADRPRRAAEDKQSPRGLAPAPGPAPRWGLSVLPAAPSQPLRPAAGPWPLALSWSSAARLRFPARRRYGDSHETPAAPAPANGSARRRETRTSLFQDGGASVASSRAGGKPAKPSKAAARERTEGAVAAVGGGSGSFRCCYGCCHAARLGRSSLPRGVIMLTETSLSIWGWGSLGIVLSLITFGPFVIFYLAFYILCFVGGGFVVTLLFGKTNSEKYLEQCEHSFLPPTSTGIPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRLVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKDVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGVLLPLINQLSDPDYINQYIIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLSSRQKDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNVNTEEMWKTYRRYSDFHDFHMRITEQFENLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIRQSFFKVPPLIPKTDSDPEHCRVSAQLDDTVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADLVKRFRDAFWPNGILAETIPCRDKGIRMRTRVAGKTKLLSIMPVLEKKMAPHSSTLAWKMPWMEEPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR", "length": 1174, "header": "tr|A0AAA9SQF4-1|A0AAA9SQF4_BOVIN Isoform 1 of Sorting nexin-13 OS=Bos taurus OX=9913 GN=SNX13 PE=3 SV=1 CANONICAL=A0AAA9SQF4-1" }, "locus": { "chromosome": "4", "start_pos": 26469689, "end_pos": 26324659, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118357.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118357.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087592.1" } ] } }, { "isoform_ac": "F1MNW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4/entry#F1MNW3-1", "sequence": { "sequence": "MREGSFSPGPLPPYTRDARGPPRQPSEPRPPPLHPRADRPRRAAEDKQSPRGLAPAPGPAPRWGLSVLPAAPSQPLRPAAGPWPLALSWSSAARLRFPARRRYGDSHETPAAPAPANGSARRRETRTSLFQDGGASVASSRAGGKPAKPSKAAARERTEGAVAAVGGGSGSFRCCYGCCHAARLGRSSLPRGVIMLTETSLSIWGWGSLGIVLSLITFGPFVIFYLAFYILCFVGGGFVVTLLFGKTNSEKYLEQCEHSFLPPTSTGIPKCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRLVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKDVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRYFVREILARGVLLPLINQLSDPDYINQYIIWMIRDSNCNYEAFMNIIKLSDNIGELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLSSRQKDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFRGSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRRNVNTEEMWKTYRRYSDFHDFHMRITEQFENLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLTPEMMKASPALAHYVYDFLENKAYSKGKGDFARKVPPLIPKTDSDPEHCRVSAQLDDTVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDWMTSPEQVADLVKRFRDAFWPNGILAETIPCRDKGIRMRTRVAGKTKLLSIMPDELKHIIGAETTRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR", "length": 1097, "header": "tr|F1MNW3-1|A0AAA9SQF4_BOVIN Computationally mapped isoform of Sorting nexin-13 OS=Bos taurus OX=9913 GN=SNX13 PE=3 SV=3 CANONICAL=A0AAA9SQF4-1" }, "locus": { "chromosome": "4", "start_pos": 26469689, "end_pos": 26324659, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018702.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018702.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018702.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018702.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 672, "start_aa": "Thr", "end_pos": 672, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr672", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" }, { "name": "negative regulation of signal transduction", "id": "GO:0009968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 730, "end_pos": 732, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" }, { "start_pos": 746, "end_pos": 748, "annotation": "n_glycosylation_sequon" }, { "start_pos": 812, "end_pos": 814, "annotation": "n_glycosylation_sequon" }, { "start_pos": 896, "end_pos": 898, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 753, "end_pos": 874, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" }, { "id": "PS51207", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51207" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PXA", "eco_id": "ECO_0000259", "start_pos": 291, "end_pos": 478, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQF4" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 567, "end_pos": 690, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 672 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 626, "end_pos": 628 }, { "start_pos": 730, "end_pos": 732 }, { "start_pos": 738, "end_pos": 740 }, { "start_pos": 746, "end_pos": 748 }, { "start_pos": 812, "end_pos": 814 }, { "start_pos": 896, "end_pos": 898 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPA5-1", "uniprot_ac": "A0AAA9SPA5", "uniprot_id": "A0AAA9SPA5_BOVIN", "mass": { "chemical_mass": 32799.0, "monoisotopic_mass": 32799.0 }, "refseq": { "ac": "XP_059744681", "name": "protein Largen isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744681" }, "gene_names": [ { "name": "PRR16", "type": "recommended", "evidence": [ { "id": "A0AAA9SPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5" } ] }, { "name": "PRR16", "type": "synonym", "evidence": [ { "id": "XP_059744681", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744681" } ] } ], "protein_names": [ { "name": "Proline rich 16", "type": "synonym", "evidence": [ { "id": "A0AAA9SPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5/entry#names_and_taxonomy" } ] }, { "name": "protein Largen isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059744681", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744681" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRR16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5", "locus": { "chromosome": "7", "start_pos": 33203285, "end_pos": 33470696, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050473", "url": "https://www.ensembl.org/id/ENSBTAG00000050473" } ] } } ], "crossref": [ { "id": "A0AAA9SPA5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050473", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050473", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615789", "url": "https://www.ncbi.nlm.nih.gov/gene/615789", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PGKLPHQ", "url": "https://omabrowser.org/oma/group/PGKLPHQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVC0", "url": "https://www.orthodb.org/?gene=A0A3Q1LVC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15917", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15917", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15917:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15917:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059744681", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744681", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAKSKGTPSSSSPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKVQANAPLIKPPAHPSAILTVLRKPNPPAPPPRLTPVKCEDSQRVVPTVNPVKTNGTLLRNGGFPGAPTKIPNGDIYCKPSSNLDKAPGQPLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYHVKNREVHLHSEPVHPPGKLPPQGPPHPLPPHLPPFPLENGGLGISHSNSFPPLRPATVPPPIAPKPQKTILRKSTTTTV", "length": 304, "header": "tr|A0AAA9SPA5-1|A0AAA9SPA5_BOVIN Isoform 1 of Proline rich 16 OS=Bos taurus OX=9913 GN=PRR16 PE=4 SV=1 CANONICAL=A0AAA9SPA5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5/entry#A0A3Q1LVC0-1", "sequence": { "sequence": "MSAKSKGTPSSSSPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEERRRRWHRTPVLLPGKSHGWRSLVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKVQANAPLIKPPAHPSAILTVLRKPNPPAPPPRLTPVKCEDSQRVVPTVNPVKTNGTLLRNGGFPGAPTKIPNGDIYCKPSSNLDKAPGQPLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYHVKNREVHLHSEPVHPPGKLPPQGPPHPLPPHLPPFPLENGGLGISHSNSFPPLRPATVPPPIAPKPQKTILRKSTTTTV", "length": 327, "header": "tr|A0A3Q1LVC0-1|A0AAA9SPA5_BOVIN Computationally mapped isoform of Proline rich 16 OS=Bos taurus OX=9913 GN=PRR16 PE=4 SV=2 CANONICAL=A0AAA9SPA5-1" }, "locus": { "chromosome": "7", "start_pos": 33388359, "end_pos": 33203832, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079789.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079789.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061143.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061143.2" } ] } }, { "isoform_ac": "A0AAA9SAJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5/entry#A0AAA9SAJ6-1", "sequence": { "sequence": "MPEKERRRRWHRTPVLLPGKSHGWRSLVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKVQANAPLIKPPAHPSAILTVLRKPNPPAPPPRLTPVKCEDSQRVVPTVNPVKTNGTLLRNGGFPGAPTKIPNGDIYCKPSSNLDKAPGQPLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYHVKNREVHLHSEPVHPPGKLPPQGPPHPLPPHLPPFPLENGGLGISHSNSFPPLRPATVPPPIAPKPQKTILRKSTTTTV", "length": 278, "header": "tr|A0AAA9SAJ6-1|A0AAA9SPA5_BOVIN Computationally mapped isoform of Proline rich 16 OS=Bos taurus OX=9913 GN=PRR16 PE=4 SV=1 CANONICAL=A0AAA9SPA5-1" }, "locus": { "chromosome": "7", "start_pos": 33263355, "end_pos": 33203832, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115636.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115636.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079197.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079197.1" } ] } }, { "isoform_ac": "A0AAA9SPA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5/entry#A0AAA9SPA5-1", "sequence": { "sequence": "MSAKSKGTPSSSSPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKVQANAPLIKPPAHPSAILTVLRKPNPPAPPPRLTPVKCEDSQRVVPTVNPVKTNGTLLRNGGFPGAPTKIPNGDIYCKPSSNLDKAPGQPLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYHVKNREVHLHSEPVHPPGKLPPQGPPHPLPPHLPPFPLENGGLGISHSNSFPPLRPATVPPPIAPKPQKTILRKSTTTTV", "length": 304, "header": "tr|A0AAA9SPA5-1|A0AAA9SPA5_BOVIN Isoform 1 of Proline rich 16 OS=Bos taurus OX=9913 GN=PRR16 PE=4 SV=1 CANONICAL=A0AAA9SPA5-1" }, "locus": { "chromosome": "7", "start_pos": 33388359, "end_pos": 33203832, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116026.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116026.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085819.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287B223-1", "protein_name": "Proline rich 16", "gene_name": "PRR16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAKSKGTPASSSPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPQRVVPTVNPVKTNGTLLRNGGFPGAPNKIPNGDICCKPGSIVDKAPVQPLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKLPPQGPHHPPPPHLPPFPLENGGLGISHSNSFPPLRPATVPPPTAPKPQKTILRKSTTTTV", "length": 304 }, "evidence": [ { "id": "A0AAA9SPA5", "url": "https://omabrowser.org/oma/group/A0AAA9SPA5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A7G3-1", "protein_name": "Proline rich 16", "gene_name": "Prr16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAKSKGNPSSSSAAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQKAAPTANPLKTNGTLLRNGGLPGRPNKIPNGDICCVPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCETRYNIKNREVHLHSEPVHPPGKLPHYGPVLPPPPHLPTFPLENGGLGISHSNSFPPHTPATVPPPPTAPKPQKTILRKSTTTTV", "length": 305 }, "evidence": [ { "id": "A0AAA9SPA5", "url": "https://omabrowser.org/oma/group/A0AAA9SPA5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A3KMN5-1", "protein_name": "Protein Largen", "gene_name": "Prr16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAKSKGNPSSSSAAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV", "length": 304 }, "evidence": [ { "id": "A0AAA9SPA5", "url": "https://omabrowser.org/oma/group/A0AAA9SPA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E1BW34-1", "protein_name": "Proline rich 16", "gene_name": "PRR16", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAQSKGTASSSSSPSEGPPAASKAKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSSTTASSLEKVKVRGSTPLIKNPVHPSAILTVLRKPNPPPPPPRLTPVKCDKQLRPPPSANPVKTNGTLLRNGPSRIPNGDLCCIPNSNLDSVAIPPLMHRPEKERCPQAGARERVRFSEKVQYHGYCPDCDVRYNIKNREVHLHSEPAHLLGALPHQCPPLPPPPPPLPPFPLENGGLGISSSNSFPPPRPVTVPPQTAPKPQKTILRKSTTTTV", "length": 301 }, "evidence": [ { "id": "A0AAA9SPA5", "url": "https://omabrowser.org/oma/group/A0AAA9SPA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q569H4-1", "protein_name": "Protein Largen", "gene_name": "PRR16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSLEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPKRVVPTANPVKTNGTLLRNGGLPGGPNKIPNGDICCIPNSNLDKAPVQLLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKIPHQGPPLPPTPHLPPFPLENGGMGISHSNSFPPIRPATVPPPTAPKPQKTILRKSTTTTV", "length": 304 }, "evidence": [ { "id": "A0AAA9SPA5", "url": "https://omabrowser.org/oma/group/A0AAA9SPA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5" } ], "pmid": "" }, { "name": "positive regulation of cell size", "id": "GO:0045793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQC8-1", "uniprot_ac": "A0AAA9SQC8", "uniprot_id": "A0AAA9SQC8_BOVIN", "mass": { "chemical_mass": 34840.0, "monoisotopic_mass": 34840.0 }, "refseq": { "ac": "XP_024838719", "name": "BTB/POZ domain-containing protein KCTD6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838719" }, "gene_names": [ { "name": "KCTD6", "type": "recommended", "evidence": [ { "id": "A0AAA9SQC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ] }, { "name": "KCTD6", "type": "synonym", "evidence": [ { "id": "XP_024838719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838719" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838719" } ] }, { "name": "Potassium channel tetramerization domain containing 6", "type": "synonym", "evidence": [ { "id": "A0AAA9SQC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8", "locus": { "chromosome": "22", "start_pos": 42869781, "end_pos": 42919373, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022656", "url": "https://www.ensembl.org/id/ENSBTAG00000022656" } ] } } ], "crossref": [ { "id": "A0AAA9SQC8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18394", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18394", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613649", "url": "https://www.ncbi.nlm.nih.gov/gene/613649", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF30", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q258", "url": "https://www.uniprot.org/uniprotkb/F6Q258", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q258-1", "url": "https://www.uniprot.org/uniprotkb/F6Q258-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIRVSSFVFYLSLVSFFSFLASPMSYSTVWIFAEWSCLRSKIAVSNHTGHFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 301, "header": "tr|A0AAA9SQC8-1|A0AAA9SQC8_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0A3Q1LWW6-1", "sequence": { "sequence": "MPRFVCARAFLMLDVRGDKWPCFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 273, "header": "tr|A0A3Q1LWW6-1|A0AAA9SQC8_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42879583, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071132.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071132.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059966.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059966.2" } ] } }, { "isoform_ac": "A0A3Q1MF30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0A3Q1MF30-1", "sequence": { "sequence": "MSSGCPFLSASLVTLMIDCFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 270, "header": "tr|A0A3Q1MF30-1|A0AAA9SQC8_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42873797, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085718.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085718.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072783.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072783.2" } ] } }, { "isoform_ac": "A0AAA9SHV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0AAA9SHV7-1", "sequence": { "sequence": "MTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 228, "header": "tr|A0AAA9SHV7-1|A0AAA9SQC8_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42871652, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134884.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134884.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085807.1" } ] } }, { "isoform_ac": "A0AAA9SN90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0AAA9SN90-1", "sequence": { "sequence": "MDIFTLFPTLEEKHSLFDHFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 270, "header": "tr|A0AAA9SN90-1|A0AAA9SN90_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42908591, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084305.1" } ] } }, { "isoform_ac": "A0AAA9SQC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0AAA9SQC8-1", "sequence": { "sequence": "MIRVSSFVFYLSLVSFFSFLASPMSYSTVWIFAEWSCLRSKIAVSNHTGHFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 301, "header": "tr|A0AAA9SQC8-1|A0AAA9SQC8_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42876040, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094967.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094967.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086204.1" } ] } }, { "isoform_ac": "A0AAA9TIP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0AAA9TIP2-1", "sequence": { "sequence": "MVLLLLLLSRFSHVRLCATQWTAAHQAPLSLGFSSFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 286, "header": "tr|A0AAA9TIP2-1|A0AAA9TIP2_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42876846, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118832.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118832.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098330.1" } ] } }, { "isoform_ac": "A0AAA9TKI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#A0AAA9TKI5-1", "sequence": { "sequence": "MPGPPILGPQEAAGTLVPQLSFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 272, "header": "tr|A0AAA9TKI5-1|A0AAA9TKI5_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42887263, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104807.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104807.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097460.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097460.1" } ] } }, { "isoform_ac": "F6Q258-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8/entry#F6Q258-1", "sequence": { "sequence": "MIVQINTRGSHILEMVTHSFPGTWAPRDAALEQMDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPVDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD", "length": 270, "header": "tr|F6Q258-1|F6Q258_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 6 OS=Bos taurus OX=9913 GN=KCTD6 PE=4 SV=1 CANONICAL=A0AAA9SQC8-1" }, "locus": { "chromosome": "22", "start_pos": 42882524, "end_pos": 42870969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030714.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030714.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030686.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030686.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "pmid": "" }, { "name": "negative regulation of smoothened signaling pathway", "id": "GO:0045879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "pmid": "" }, { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "pmid": "" }, { "name": "ankyrin binding", "id": "GO:0030506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQC8" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 76, "end_pos": 177, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 289, "end_pos": 291 }, { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNE2-1", "uniprot_ac": "A0AAA9SNE2", "uniprot_id": "A0AAA9SNE2_BOVIN", "mass": { "chemical_mass": 18591.0, "monoisotopic_mass": 18591.0 }, "refseq": { "ac": "XP_024832629", "name": "CD164 sialomucin-like 2 protein isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832629" }, "gene_names": [ { "name": "CD164L2", "type": "recommended", "evidence": [ { "id": "A0AAA9SNE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2" } ] }, { "name": "CD164L2", "type": "synonym", "evidence": [ { "id": "XP_024832629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832629" } ] } ], "protein_names": [ { "name": "CD164 molecule like 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SNE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#names_and_taxonomy" } ] }, { "name": "CD164 sialomucin-like 2 protein isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024832629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832629" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD164L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2", "locus": { "chromosome": "2", "start_pos": 125919415, "end_pos": 125905878, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019728", "url": "https://www.ensembl.org/id/ENSBTAG00000019728" } ] } } ], "crossref": [ { "id": "A0AAA9SNE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019728", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019728", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539662", "url": "https://www.ncbi.nlm.nih.gov/gene/539662", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11337", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11337", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11337:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11337:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05283", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05283", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024832629", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832629", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMI0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S0", "url": "https://www.uniprot.org/uniprotkb/F1N2S0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2S0-1", "url": "https://www.uniprot.org/uniprotkb/F1N2S0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPGPRALRAALCGGCCCLLLCAQLAVAGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTLI", "length": 174, "header": "tr|A0AAA9SNE2-1|A0AAA9SNE2_BOVIN Isoform 1 of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=1 CANONICAL=A0AAA9SNE2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#A0A3Q1M0X2-1", "sequence": { "sequence": "MAAPGPRALRAALCGGCCCLLLCAQLAVAGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTLIMINGLVFRSWHTGSRACVVGHIPRTGIGASQRSSHGSILSGKLGLHLP", "length": 222, "header": "tr|A0A3Q1M0X2-1|A0AAA9SNE2_BOVIN Computationally mapped isoform of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=2 CANONICAL=A0AAA9SNE2-1" }, "locus": { "chromosome": "2", "start_pos": 125913507, "end_pos": 125906067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084633.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084633.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063318.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063318.2" } ] } }, { "isoform_ac": "A0A3Q1MMI0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#A0A3Q1MMI0-1", "sequence": { "sequence": "MAEAEALPGGHCSHQGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTL", "length": 159, "header": "tr|A0A3Q1MMI0-1|A0AAA9SNE2_BOVIN Computationally mapped isoform of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=2 CANONICAL=A0AAA9SNE2-1" }, "locus": { "chromosome": "2", "start_pos": 125909853, "end_pos": 125902515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068243.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068243.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073006.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073006.2" } ] } }, { "isoform_ac": "A0AAA9SAB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#A0AAA9SAB1-1", "sequence": { "sequence": "MQREGALVNVRELLGVCAHVFVETPGVRWGLGDPGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTLI", "length": 179, "header": "tr|A0AAA9SAB1-1|A0AAA9SNE2_BOVIN Computationally mapped isoform of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=1 CANONICAL=A0AAA9SNE2-1" }, "locus": { "chromosome": "2", "start_pos": 125909664, "end_pos": 125906375, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116688.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116688.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080360.1" } ] } }, { "isoform_ac": "A0AAA9SNE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#A0AAA9SNE2-1", "sequence": { "sequence": "MAAPGPRALRAALCGGCCCLLLCAQLAVAGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTLI", "length": 174, "header": "tr|A0AAA9SNE2-1|A0AAA9SNE2_BOVIN Isoform 1 of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=1 CANONICAL=A0AAA9SNE2-1" }, "locus": { "chromosome": "2", "start_pos": 125909664, "end_pos": 125906067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098904.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098904.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086866.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086866.1" } ] } }, { "isoform_ac": "A0AAA9TVB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#A0AAA9TVB9-1", "sequence": { "sequence": "MAAPGPRALRAALCGGCCCLLLCAQLAVAGVRWGLGDPGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTLI", "length": 183, "header": "tr|A0AAA9TVB9-1|A0AAA9TVB9_BOVIN Computationally mapped isoform of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=1 CANONICAL=A0AAA9SNE2-1" }, "locus": { "chromosome": "2", "start_pos": 125909664, "end_pos": 125906067, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091413.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091413.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102311.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102311.1" } ] } }, { "isoform_ac": "F1N2S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2/entry#F1N2S0-1", "sequence": { "sequence": "PRPVWATPTYPSAGKGARGFGRGALLRVNIWPAVRVACKQLKPCEHCVEGNRAHNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSESCPAVHHHPTHEPKTVTTESPLVPEAHSPGFDGASFIGGVVMVLSLQAVAFFVLRFLKAKDSTYQTL", "length": 157, "header": "tr|F1N2S0-1|F1N2S0_BOVIN Computationally mapped isoform of CD164 molecule like 2 OS=Bos taurus OX=9913 GN=CD164L2 PE=3 SV=4 CANONICAL=A0AAA9SNE2-1" }, "locus": { "chromosome": "2", "start_pos": 125909853, "end_pos": 125905915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043094.6", "url": "https://www.ensembl.org/id/ENSBTAT00000043094.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040689.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040689.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQQ3-1", "uniprot_ac": "A0AAA9SQQ3", "uniprot_id": "A0AAA9SQQ3_BOVIN", "mass": { "chemical_mass": 90541.0, "monoisotopic_mass": 90541.0 }, "refseq": { "ac": "XP_005228301", "name": "ribosomal biogenesis protein LAS1L isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228301" }, "gene_names": [ { "name": "LAS1L", "type": "recommended", "evidence": [ { "id": "A0AAA9SQQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ] }, { "name": "LAS1L", "type": "synonym", "evidence": [ { "id": "XP_005228301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228301" } ] } ], "protein_names": [ { "name": "LAS1 like ribosome biosis factor", "type": "synonym", "evidence": [ { "id": "A0AAA9SQQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3/entry#names_and_taxonomy" } ] }, { "name": "ribosomal biogenesis protein LAS1L isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005228301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228301" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAS1L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3", "locus": { "chromosome": "X", "start_pos": 94970016, "end_pos": 94949965, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002210", "url": "https://www.ensembl.org/id/ENSBTAG00000002210" } ] } } ], "crossref": [ { "id": "A0AAA9SQQ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002210", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002210", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507924", "url": "https://www.ncbi.nlm.nih.gov/gene/507924", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1H1", "url": "https://www.orthodb.org/?gene=A0A3Q1M1H1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15002:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15002:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228301", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228301", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1H1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1H1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S233", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S233", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S233-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S233-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEADREMEADHEMEDDLQCGGTRPELDVEPVEPDVEPVEPDVEPDVEPDVRSESEIEPGLGPRGMDLVWSAWCGKCVKEKGSSPLWAQRIVVAWLSRAEWDQVMVYLFSDDYKLQRYALNRITVWRSRLGNELPLAVASTADLVRCKLMDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKLPLKFLAQEVNIPDWIVELRHELTHKKMPHINDCRRGCYFVLDWLQNTYWCRQMENSLRETWELEEEREETDEADQEEDKKIVVDDITEQNPEPKDEEKGVELNVKTDGDRESNKDGKEVDPLLQKALRHKQLYERARELLVSYEEEQFKVLEKYRHLPQAIKAWNNLSPPVECILAELKGITLENREAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLDDVLVPKPFSQFWQPLLRGLHSQTFTQALLERMLSELPALGNTGIRPTYILRWTTELIVANTKTGRNARRFSASQWEARKNWRLFNCSASLDWPQVVESCLGSPCWASPQLLQLIFKAMGQFLPDEEQEKLLRICSIYTQSGENLVQEGSEASPIGKSPYTVDNLYLILKPAGSSSGAEGEAQKQEEQGNLNDVKEDEKENKEAVEDQVEENEEEEENDHQKWEEEEEDDGHDDNDNDDEDEEDRMEVGPFSTEEESPTAENARLLAQKRGALQDSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYLLDQPVLEQRLEPPACKIGTLGLSCSSGSNDSGNLDQLLWSQEELHMLKTSVQLF", "length": 790, "header": "tr|A0AAA9SQQ3-1|A0AAA9SQQ3_BOVIN Isoform 1 of LAS1 like ribosome biosis factor OS=Bos taurus OX=9913 GN=LAS1L PE=4 SV=1 CANONICAL=A0AAA9SQQ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3/entry#A0A3Q1M1H1-1", "sequence": { "sequence": "MRWRMIFSAAAQGLSSMLSPLSPMLSPLSPMLSPMLSPMSGRNPRLSQRYALNRITVWRSRLGNELPLAVASTADLVRCKLMDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKLPLKFLAQEVNIPDWIVELRHELTHKKMPHINDCRRGCYFVLDWLQNTYWCRQMENSLRETWELEEEREETDEADQEEDKKIVVDDITEQNPEPKDEEKGVELNVKTDGDRESNKDGKEVDPLLQKALRHKQLYERARELLVSYEEEQFKVLEKYRHLPQAIKAWNNLSPPVECILAELKGITLENREAVLDAFLDDGFLIPTFEQLAALQIEYEENVDLDDVLVPKPFSQFWQPLLRGLHSQTFTQALLERMLSELPALGNTGIRPTYILRWTTELIVANTKTGRNARRFSASQWEARKNWRLFNCSASLDWPQVVESCLGSPCWASPQLLQLIFKAMGQFLPDEEQEKLLRICSIYTQSGENLVQEGSEASPIGKSPYTVDNLYLILKPAGSSSGAEGEAQKQEEQGNLNDVKEDEKENKEAVEDQVEENEEEEENDHQKWEEEEEDDGHDDNDNDDEDEEDRMEVGPFSTEEESPTAENARLLAQKRGALQDSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYLLDQPVLEQRLEPPACKIGTLGLSCSSGSNDSGNLDQLLWSQEELHMLKTSVQLF", "length": 706, "header": "tr|A0A3Q1M1H1-1|A0AAA9SQQ3_BOVIN Computationally mapped isoform of LAS1 like ribosome biosis factor OS=Bos taurus OX=9913 GN=LAS1L PE=4 SV=1 CANONICAL=A0AAA9SQQ3-1" }, "locus": { "chromosome": "X", "start_pos": 94969799, "end_pos": 94950164, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079382.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079382.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067182.1" } ] } }, { "isoform_ac": "A0AAA9S233-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3/entry#A0AAA9S233-1", "sequence": { "sequence": "MEADREMEADHEMEDDLQCGGTRPELDVEPVEPDVEPVEPDVEPDVEPDVRSESEIEPGLGPRGMDLVWSAWCGKCVKEKGSSPLWAQRIVVAWLSRAEWDQVMVYLFSDDYKLQRYALNRITVWRSRLGNELPLAVASTADLVRCKLMDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKLPLKFLAQEVNIPDWIVELRHELTHKKMPHINDCRRGCYFVLDWLQNTYWCRQMENSLRETWELEEEREETDEADQEEDKKIVVDDITEQNPEPKDEEKGVELNVKTDGDRESNKDGKEVDPLLQKALRHKQLYERARELLVSYEEEQFKVLEKYRHLPQAIKAWNNLSPPVECILAELKGITLENREAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLDDVLVPKPFSQFWQPLLRGLHSQTFTQALLERMLSELPALGNTGIRPTYILRWTTELIVANTKTGRNARRFSASQWEARKNWRLFNCSASLDWPQVVESCLGSPCWASPQLLQLILFGGN", "length": 541, "header": "tr|A0AAA9S233-1|A0AAA9SQQ3_BOVIN Computationally mapped isoform of LAS1 like ribosome biosis factor OS=Bos taurus OX=9913 GN=LAS1L PE=4 SV=2 CANONICAL=A0AAA9SQQ3-1" }, "locus": { "chromosome": "X", "start_pos": 94961341, "end_pos": 94950133, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087875.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087875.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077752.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077752.2" } ] } }, { "isoform_ac": "A0AAA9SQQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3/entry#A0AAA9SQQ3-1", "sequence": { "sequence": "MEADREMEADHEMEDDLQCGGTRPELDVEPVEPDVEPVEPDVEPDVEPDVRSESEIEPGLGPRGMDLVWSAWCGKCVKEKGSSPLWAQRIVVAWLSRAEWDQVMVYLFSDDYKLQRYALNRITVWRSRLGNELPLAVASTADLVRCKLMDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKLPLKFLAQEVNIPDWIVELRHELTHKKMPHINDCRRGCYFVLDWLQNTYWCRQMENSLRETWELEEEREETDEADQEEDKKIVVDDITEQNPEPKDEEKGVELNVKTDGDRESNKDGKEVDPLLQKALRHKQLYERARELLVSYEEEQFKVLEKYRHLPQAIKAWNNLSPPVECILAELKGITLENREAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLDDVLVPKPFSQFWQPLLRGLHSQTFTQALLERMLSELPALGNTGIRPTYILRWTTELIVANTKTGRNARRFSASQWEARKNWRLFNCSASLDWPQVVESCLGSPCWASPQLLQLIFKAMGQFLPDEEQEKLLRICSIYTQSGENLVQEGSEASPIGKSPYTVDNLYLILKPAGSSSGAEGEAQKQEEQGNLNDVKEDEKENKEAVEDQVEENEEEEENDHQKWEEEEEDDGHDDNDNDDEDEEDRMEVGPFSTEEESPTAENARLLAQKRGALQDSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYLLDQPVLEQRLEPPACKIGTLGLSCSSGSNDSGNLDQLLWSQEELHMLKTSVQLF", "length": 790, "header": "tr|A0AAA9SQQ3-1|A0AAA9SQQ3_BOVIN Isoform 1 of LAS1 like ribosome biosis factor OS=Bos taurus OX=9913 GN=LAS1L PE=4 SV=1 CANONICAL=A0AAA9SQQ3-1" }, "locus": { "chromosome": "X", "start_pos": 94969799, "end_pos": 94950133, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130037.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130037.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085281.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085281.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Las1 complex", "id": "GO:0090730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ], "pmid": "" }, { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 507, "end_pos": 509, "annotation": "n_glycosylation_sequon" }, { "start_pos": 765, "end_pos": 767, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 351, "end_pos": 353 }, { "start_pos": 507, "end_pos": 509 }, { "start_pos": 765, "end_pos": 767 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPB2-1", "uniprot_ac": "A0AAA9SPB2", "uniprot_id": "A0AAA9SPB2_BOVIN", "mass": { "chemical_mass": 92860.0, "monoisotopic_mass": 92860.0 }, "refseq": {}, "gene_names": [ { "name": "TRPV4", "type": "recommended", "evidence": [ { "id": "A0AAA9SPB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ] } ], "protein_names": [ { "name": "Transient receptor potential cation channel subfamily V member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SPB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2", "locus": { "chromosome": "17", "start_pos": 63453042, "end_pos": 63410291, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000031", "url": "https://www.ensembl.org/id/ENSBTAG00000000031" } ] } } ], "crossref": [ { "id": "A0AAA9SPB2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22195", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22195", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10582:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M8H5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8H5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8H5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPGEGPRVGPGEMAESPGDESGPPGGEAFPLSSLANLFEGEDGSPSPSPADGGRSTGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEETSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTMDYLRLAGEIITLFTGILFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANLKVCDEDHANCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNENYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDNVGNPSCDGHQQSYPPKWRTDDAPL", "length": 824, "header": "tr|A0AAA9SPB2-1|A0AAA9SPB2_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily V member 4 OS=Bos taurus OX=9913 GN=TRPV4 PE=4 SV=1 CANONICAL=A0AAA9SPB2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2/entry#A0A3Q1M8H5-1", "sequence": { "sequence": "MADPGEGPRVGPGEMAESPGDESGPPGGEAFPLSSLANLFEGEDGSPSPSPADGGRSTGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEETSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANLKVCDEDHANCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNENYQYYGFSHTVGRLRRGTIRTGCDAWNCSSHFVIMKGLSGAERRKGHGYLISPLC", "length": 827, "header": "tr|A0A3Q1M8H5-1|A0AAA9SPB2_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily V member 4 OS=Bos taurus OX=9913 GN=TRPV4 PE=4 SV=1 CANONICAL=A0AAA9SPB2-1" }, "locus": { "chromosome": "17", "start_pos": 63452454, "end_pos": 63426727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085000.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085000.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066419.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066419.2" } ] } }, { "isoform_ac": "A0AAA9SPB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2/entry#A0AAA9SPB2-1", "sequence": { "sequence": "MADPGEGPRVGPGEMAESPGDESGPPGGEAFPLSSLANLFEGEDGSPSPSPADGGRSTGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEETSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTMDYLRLAGEIITLFTGILFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANLKVCDEDHANCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNENYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDNVGNPSCDGHQQSYPPKWRTDDAPL", "length": 824, "header": "tr|A0AAA9SPB2-1|A0AAA9SPB2_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily V member 4 OS=Bos taurus OX=9913 GN=TRPV4 PE=4 SV=1 CANONICAL=A0AAA9SPB2-1" }, "locus": { "chromosome": "17", "start_pos": 63446659, "end_pos": 63426727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095651.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095651.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085829.1" } ] } }, { "isoform_ac": "A0AAA9TMC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2/entry#A0AAA9TMC3-1", "sequence": { "sequence": "MADPGEGPRVGPGEMAESPGDESGPPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEETSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTMDYLRLAGEIITLFTGILFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANLKVCDEDHANCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNENYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDNVGNPSCDGHQQSYPPKWRTDDAPL", "length": 837, "header": "tr|A0AAA9TMC3-1|A0AAA9TMC3_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily V member 4 OS=Bos taurus OX=9913 GN=TRPV4 PE=4 SV=1 CANONICAL=A0AAA9SPB2-1" }, "locus": { "chromosome": "17", "start_pos": 63446659, "end_pos": 63426727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125194.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125194.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098136.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098136.1" } ] } }, { "isoform_ac": "A0AAA9TSJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2/entry#A0AAA9TSJ4-1", "sequence": { "sequence": "MADPGEGPRVGPGEMAESPGDESGPPGGEAFPLSSLANLFEGEDGSPSPSPADGGRSTGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTMDYLRLAGEIITLFTGILFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANLKVCDEDHANCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKNENYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDNVGNPSCDGHQQSYPPKWRTDDAPL", "length": 811, "header": "tr|A0AAA9TSJ4-1|A0AAA9TSJ4_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily V member 4 OS=Bos taurus OX=9913 GN=TRPV4 PE=4 SV=1 CANONICAL=A0AAA9SPB2-1" }, "locus": { "chromosome": "17", "start_pos": 63446659, "end_pos": 63426727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125590.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125590.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101573.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 737, "end_pos": 739, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB2" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 428, "end_pos": 682, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 201, "end_pos": 203 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 737, "end_pos": 739 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPH1-1", "uniprot_ac": "A0AAA9SPH1", "uniprot_id": "A0AAA9SPH1_BOVIN", "mass": { "chemical_mass": 34870.0, "monoisotopic_mass": 34870.0 }, "refseq": { "ac": "XP_059735143", "name": "iron-sulfur cluster transfer protein NUBPL isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735143" }, "gene_names": [ { "name": "NUBPL", "type": "recommended", "evidence": [ { "id": "A0AAA9SPH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ] }, { "name": "NUBPL", "type": "synonym", "evidence": [ { "id": "XP_059735143", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735143" } ] } ], "protein_names": [ { "name": "Iron-sulfur cluster transfer protein NUBPL", "type": "recommended", "evidence": [ { "id": "A0AAA9SPH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#names_and_taxonomy" } ] }, { "name": "Nucleotide-binding protein-like", "type": "synonym", "evidence": [ { "id": "A0AAA9SPH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#names_and_taxonomy" } ] }, { "name": "iron-sulfur cluster transfer protein NUBPL isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059735143", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735143" } ] } ], "function": [ { "annotation": "Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver one or more Fe-S clusters to complex I subunits.", "evidence": [ { "database": "UniProtKB", "id": "E1BE32", "url": "https://www.uniprot.org/uniprotkb/E1BE32#function" }, { "database": "UniProtKB", "id": "ARBA00056637", "url": "https://www.uniprot.org/uniprotkb/ARBA00056637#function" }, { "database": "UniProtKB", "id": "A0A3Q1M8H6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8H6#function" }, { "database": "UniProtKB", "id": "A0AAA9RTQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTQ9#function" }, { "database": "UniProtKB", "id": "A0AAA9T778", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T778#function" }, { "database": "UniProtKB", "id": "A0AAA9TAY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAY8#function" }, { "database": "UniProtKB", "id": "A0AAA9SLE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE8#function" }, { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1#function" }, { "database": "UniProtKB", "id": "A0AAA9SVS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS3#function" }, { "database": "UniProtKB", "id": "A0AAA9T5P4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUBPL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1", "locus": { "chromosome": "21", "start_pos": 42454230, "end_pos": 42056589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044121", "url": "https://www.ensembl.org/id/ENSBTAG00000044121" } ] } } ], "crossref": [ { "id": "A0AAA9SPH1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044121", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044121", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02037", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02037", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614641", "url": "https://www.ncbi.nlm.nih.gov/gene/614641", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BE32", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BE32*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8H6", "url": "https://www.orthodb.org/?gene=A0A3Q1M8H6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BE32", "url": "https://www.orthodb.org/?gene=E1BE32", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42961", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42961", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42961:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42961:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10609", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10609", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059735143", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735143", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8H6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8H6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8H6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5P4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T778", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T778", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T778-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T778-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE32", "url": "https://www.uniprot.org/uniprotkb/E1BE32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE32-1", "url": "https://www.uniprot.org/uniprotkb/E1BE32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDEMTPPLWQKGRGTKKPLDESERGE", "length": 322, "header": "tr|A0AAA9SPH1-1|A0AAA9SPH1_BOVIN Isoform 1 of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0A3Q1M8H6-1", "sequence": { "sequence": "MEAERCYGTSSPRARRDGFRIGLQTVFRAMGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDEGSFESQNLLTLPGQN", "length": 343, "header": "tr|A0A3Q1M8H6-1|A0AAA9SPH1_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=2 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42382128, "end_pos": 42056593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084233.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084233.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066749.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066749.2" } ] } }, { "isoform_ac": "A0AAA9RTQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9RTQ9-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDERCKLT", "length": 304, "header": "tr|A0AAA9RTQ9-1|A0AAA9SPH1_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42372367, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075355.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075355.1" } ] } }, { "isoform_ac": "A0AAA9SLE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9SLE8-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSGKFSEQRSTETGEGKSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIATEVVRRLPPPPESFPKCLGNLPGL", "length": 346, "header": "tr|A0AAA9SLE8-1|A0AAA9SPH1_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=2 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42300069, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115698.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115698.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087196.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087196.2" } ] } }, { "isoform_ac": "A0AAA9SPH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9SPH1-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDEMTPPLWQKGRGTKKPLDESERGE", "length": 322, "header": "tr|A0AAA9SPH1-1|A0AAA9SPH1_BOVIN Isoform 1 of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42294282, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130963.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130963.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084811.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084811.1" } ] } }, { "isoform_ac": "A0AAA9SVS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9SVS3-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDESGEIQEPADQEGE", "length": 312, "header": "tr|A0AAA9SVS3-1|A0AAA9SVS3_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42376479, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126159.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126159.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088297.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088297.1" } ] } }, { "isoform_ac": "A0AAA9T5P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9T5P4-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDESTKEGPGPERC", "length": 310, "header": "tr|A0AAA9T5P4-1|A0AAA9T5P4_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42431359, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099951.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099951.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092050.1" } ] } }, { "isoform_ac": "A0AAA9T778-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9T778-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDEILLWCQDFEFQ", "length": 310, "header": "tr|A0AAA9T778-1|A0AAA9T778_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42454066, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116727.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116727.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093770.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093770.1" } ] } }, { "isoform_ac": "A0AAA9TAY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#A0AAA9TAY8-1", "sequence": { "sequence": "MGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDESWDLFCVFREHVWRMHVYIHHVLGSPASEEEGLGHGGQQAGPSFLSFLEPLESVLHI", "length": 356, "header": "tr|A0AAA9TAY8-1|A0AAA9TAY8_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=1 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42380770, "end_pos": 42056680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111471.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111471.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095163.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095163.1" } ] } }, { "isoform_ac": "E1BE32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1/entry#E1BE32-1", "sequence": { "sequence": "MEAERCYGTSSPRARRDGFRIGLQTVFRAMGVWRRLLVFGGVSLRGCGGVRVPLGGSRLVICRRQFSGAESETLKQRRSQIMSRGLPKQKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTGDVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGARRLARTLDLDILGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIATEVVRRLPPPPESFPKCLGNLPGL", "length": 360, "header": "tr|E1BE32-1|E1BE32_BOVIN Computationally mapped isoform of Iron-sulfur cluster transfer protein NUBPL OS=Bos taurus OX=9913 GN=NUBPL PE=3 SV=4 CANONICAL=A0AAA9SPH1-1" }, "locus": { "chromosome": "21", "start_pos": 42300069, "end_pos": 42056593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061529.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061529.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053647.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053647.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "iron-sulfur cluster assembly", "id": "GO:0016226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" }, { "name": "ATP-dependent FeS chaperone activity", "id": "GO:0140663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140663", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 238, "end_pos": 240 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR88-1", "uniprot_ac": "A0AAA9SR88", "uniprot_id": "A0AAA9SR88_BOVIN", "mass": { "chemical_mass": 33507.0, "monoisotopic_mass": 33507.0 }, "refseq": { "ac": "XP_005202807", "name": "Krueppel-like factor 7 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202807" }, "gene_names": [ { "name": "KLF7", "type": "recommended", "evidence": [ { "id": "A0AAA9SR88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ] }, { "name": "KLF7", "type": "synonym", "evidence": [ { "id": "XP_005202807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202807" } ] } ], "protein_names": [ { "name": "Krueppel-like factor 7", "type": "recommended", "evidence": [ { "id": "A0AAA9SR88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#names_and_taxonomy" } ] }, { "name": "Krueppel-like factor 7 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202807" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88", "locus": { "chromosome": "2", "start_pos": 95369059, "end_pos": 95468867, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044097", "url": "https://www.ensembl.org/id/ENSBTAG00000044097" } ] } } ], "crossref": [ { "id": "A0AAA9SR88", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR88", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044097", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044097", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21585", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21585", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537747", "url": "https://www.ncbi.nlm.nih.gov/gene/537747", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9G5", "url": "https://www.orthodb.org/?gene=A0A3Q1M9G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC48", "url": "https://www.orthodb.org/?gene=A0A3Q1MC48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BNF7", "url": "https://www.orthodb.org/?gene=E1BNF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005202807", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202807", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9G5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC48", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIP3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIP3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNF7", "url": "https://www.uniprot.org/uniprotkb/E1BNF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNF7-1", "url": "https://www.uniprot.org/uniprotkb/E1BNF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGSEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI", "length": 303, "header": "tr|A0AAA9SR88-1|A0AAA9SR88_BOVIN Isoform 1 of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=1 CANONICAL=A0AAA9SR88-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0A3Q1M9G5-1", "sequence": { "sequence": "MFICFFWQDPLGEGMRLTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI", "length": 285, "header": "tr|A0A3Q1M9G5-1|A0AAA9SR88_BOVIN Computationally mapped isoform of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=2 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95437445, "end_pos": 95370244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066725.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066725.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065086.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065086.2" } ] } }, { "isoform_ac": "A0A3Q1MC48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0A3Q1MC48-1", "sequence": { "sequence": "MNSLLQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGSGTSWPHVVSSFSSFSLVGGRASLCSEKWHPCQQGGIERQAGLGGKPSDSPINLRISRCPGHQTWVCHSLAWRFFQRAVPALV", "length": 300, "header": "tr|A0A3Q1MC48-1|A0AAA9SR88_BOVIN Computationally mapped isoform of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=2 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95439630, "end_pos": 95426838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066321.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066321.2" } ] } }, { "isoform_ac": "A0A3Q1MIP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0A3Q1MIP3-1", "sequence": { "sequence": "MREKQVQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI", "length": 275, "header": "tr|A0A3Q1MIP3-1|A0AAA9SR88_BOVIN Computationally mapped isoform of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95439033, "end_pos": 95370244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083782.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083782.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069044.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069044.2" } ] } }, { "isoform_ac": "A0AAA9SAH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0AAA9SAH9-1", "sequence": { "sequence": "EVRKARQVHVGPDWPWQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGSGTSWPHVVSSFSSFSLVGGRASLCSEKWHPCQQGGIERQAGLGGKPSDSPINLRISRCPGHQTWVCHSLAWRFFQRAVPALV", "length": 311, "header": "tr|A0AAA9SAH9-1|A0AAA9SR88_BOVIN Computationally mapped isoform of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95439776, "end_pos": 95426838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126740.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126740.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079181.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079181.1" } ] } }, { "isoform_ac": "A0AAA9SBX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0AAA9SBX7-1", "sequence": { "sequence": "ELNLLFLGNSSFDWTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI", "length": 282, "header": "tr|A0AAA9SBX7-1|A0AAA9SR88_BOVIN Computationally mapped isoform of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95437954, "end_pos": 95370244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091784.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091784.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081387.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081387.1" } ] } }, { "isoform_ac": "A0AAA9SR88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0AAA9SR88-1", "sequence": { "sequence": "MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGSEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI", "length": 303, "header": "tr|A0AAA9SR88-1|A0AAA9SR88_BOVIN Isoform 1 of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95468727, "end_pos": 95370244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134843.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134843.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085485.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085485.1" } ] } }, { "isoform_ac": "A0AAA9TFB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0AAA9TFB7-1", "sequence": { "sequence": "MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEHVVEKNSCFLAFCLKDLQEPPSDRHLHCLLEI", "length": 278, "header": "tr|A0AAA9TFB7-1|A0AAA9TFB7_BOVIN Computationally mapped isoform of KLF transcription factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=4 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95468727, "end_pos": 95398634, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118392.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118392.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096819.1" } ] } }, { "isoform_ac": "A0AAA9TX56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0AAA9TX56-1", "sequence": { "sequence": "MVKLSNCQDHCCSQEASLLGQHAFSQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTAGEVFWDVKREREEEKNPREREEILAFCSLELCICSISSIW", "length": 277, "header": "tr|A0AAA9TX56-1|A0AAA9TX56_BOVIN Computationally mapped isoform of KLF transcription factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=4 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95437114, "end_pos": 95423505, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101790.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101790.1" } ] } }, { "isoform_ac": "A0AAA9U0T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#A0AAA9U0T0-1", "sequence": { "sequence": "MVKLSNCQDHCCSQEASLLGQHAFSQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTDTHTHTRTHT", "length": 276, "header": "tr|A0AAA9U0T0-1|A0AAA9U0T0_BOVIN Computationally mapped isoform of KLF transcription factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=1 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95437114, "end_pos": 95370063, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126878.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126878.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103280.1" } ] } }, { "isoform_ac": "E1BNF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88/entry#E1BNF7-1", "sequence": { "sequence": "MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLRASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALGSVKVGGVATAAAAVAAAGTVKSGHSDSEQGGVGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGVFPGLTTLPSI", "length": 256, "header": "tr|E1BNF7-1|A0AAA9SR88_BOVIN Computationally mapped isoform of Krueppel-like factor 7 OS=Bos taurus OX=9913 GN=KLF7 PE=3 SV=2 CANONICAL=A0AAA9SR88-1" }, "locus": { "chromosome": "2", "start_pos": 95468727, "end_pos": 95370258, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061201.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061201.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053544.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053544.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "regulation of epidermal cell differentiation", "id": "GO:0045604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "negative regulation of insulin secretion involved in cellular response to glucose stimulus", "id": "GO:0061179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" }, { "name": "negative regulation of adipose tissue development", "id": "GO:1904178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SR88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR88" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 219, "end_pos": 248, "start_aa": "His", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNY2-1", "uniprot_ac": "A0AAA9SNY2", "uniprot_id": "A0AAA9SNY2_BOVIN", "mass": { "chemical_mass": 25453.0, "monoisotopic_mass": 25453.0 }, "refseq": {}, "gene_names": [ { "name": "MOB1B", "type": "recommended", "evidence": [ { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ] } ], "protein_names": [ { "name": "MOB kinase activator 1B", "type": "synonym", "evidence": [ { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOB1B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2", "locus": { "chromosome": "6", "start_pos": 86308361, "end_pos": 86250301, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016290", "url": "https://www.ensembl.org/id/ENSBTAG00000016290" } ] } } ], "crossref": [ { "id": "A0AAA9SNY2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016290", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016290", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515407", "url": "https://www.ncbi.nlm.nih.gov/gene/515407", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515407", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515407", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VDNEQMF", "url": "https://omabrowser.org/oma/group/VDNEQMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBK1", "url": "https://www.orthodb.org/?gene=A0A3Q1MBK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2028269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2028269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MBK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBK1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VEGATDVNDSGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 221, "header": "tr|A0AAA9SNY2-1|A0AAA9SNY2_BOVIN Isoform 1 of MOB kinase activator 1B OS=Bos taurus OX=9913 GN=MOB1B PE=4 SV=1 CANONICAL=A0AAA9SNY2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2/entry#A0A3Q1MBK1-1", "sequence": { "sequence": "MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 216, "header": "tr|A0A3Q1MBK1-1|A0AAA9SNY2_BOVIN Computationally mapped isoform of MOB kinase activator 1B OS=Bos taurus OX=9913 GN=MOB1B PE=4 SV=1 CANONICAL=A0AAA9SNY2-1" }, "locus": { "chromosome": "6", "start_pos": 86302671, "end_pos": 86250441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081480.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081480.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067654.1" } ] } }, { "isoform_ac": "A0AAA9SNY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2/entry#A0AAA9SNY2-1", "sequence": { "sequence": "VEGATDVNDSGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 221, "header": "tr|A0AAA9SNY2-1|A0AAA9SNY2_BOVIN Isoform 1 of MOB kinase activator 1B OS=Bos taurus OX=9913 GN=MOB1B PE=4 SV=1 CANONICAL=A0AAA9SNY2-1" }, "locus": { "chromosome": "6", "start_pos": 86302671, "end_pos": 86281193, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115748.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115748.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085654.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515407", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515407", "resource": "KEGG Pathway" }, { "id": "R-BTA-2028269", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2028269", "resource": "Reactome", "description": "Signaling by Hippo" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LP48-1", "protein_name": "MOB kinase activator 1B isoform X1", "gene_name": "Mob1b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 216 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XM20-1", "protein_name": "MOB kinase activator 1A", "gene_name": "MOB1B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 216 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q54XJ0-1", "protein_name": "MOB kinase activator-like 1 homolog A", "gene_name": "mobA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNIFGKKSQTFKPKKNIQEGSKQYHLKQYAEATLGSGNLKSAVSLPTGEDINEWLAVNTTDFFNQINMLYGTITEFCTGTDCPVMSAGPKYEYHWADGTTVKKAIKVSAPEYVDFLMTWVQSQLDDENIFPSKIGVPFPKNFQSIVKTIFKRLFRVYAHIYHSHFQKIVSLGEEAHLNTSLKHFIYFIQEFNLVDKKELGPLNELIESLMKNP", "length": 213 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7L9L4-1", "protein_name": "MOB kinase activator 1B", "gene_name": "MOB1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 216 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BPB0-1", "protein_name": "MOB kinase activator 1B", "gene_name": "Mob1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR", "length": 216 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q95RA8-1", "protein_name": "MOB kinase activator-like 1", "gene_name": "mats", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDFLFGSRSSKTFKPKKNIPEGTHQYDLMKHAAATLGSGNLRNAVALPDGEDLNEWVAVNTVDFFNQINMLYGTITEFCTEETCGIMSAGPKYEYHWADGLTVKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFHSSAKTILKRLFRVYAHIYHQHFTEVVTLGEEAHLNTSFKHFIFFVQEFNLIERRELAPLQELIDKLTAKDERQI", "length": 219 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9FHI1-1", "protein_name": "MOB kinase activator-like 1A", "gene_name": "MOB1A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSLFGLGRNQKTFRPKKSAPSGSKGAQLRKHIDATLGSGNLREAVRLPPGEDANEWLAVNTVDFFNQVNLLYGTLTEFCTPDNCPTMTAGPKYEYRWADGVQIKKPIEVSAPKYVEYLMDWIETQLDDETLFPQRLGAPFPQNFKDVVKTIFKRLFRVYAHIYHSHFQKIVSLKEEAHLNTCFKHFILFTHEFGLIDKKELAPLQELIESIISPY", "length": 215 }, "evidence": [ { "id": "A0AAA9SNY2", "url": "https://omabrowser.org/oma/group/A0AAA9SNY2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "protein kinase activator activity", "id": "GO:0030295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "hippo signaling", "id": "GO:0035329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035329", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1#function" }, { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1" }, { "id": "PIRSR605301-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605301-1" } ], "binding_site_uniprot": 161, "amino_acid": "Phe", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 161, "end_pos": 161, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2#function" }, { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" }, { "id": "PIRSR605301-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605301-1" }, { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1#function" }, { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1" } ], "binding_site_uniprot": 166, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 166, "end_pos": 166, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2#function" }, { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" }, { "id": "PIRSR605301-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605301-1" } ], "binding_site_uniprot": 171, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 171, "end_pos": 171, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1#function" }, { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1" }, { "id": "PIRSR605301-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605301-1" } ], "binding_site_uniprot": 79, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 79, "end_pos": 79, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2#function" }, { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" }, { "id": "PIRSR605301-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605301-1" }, { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1#function" }, { "id": "A0A3Q1MBK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBK1" } ], "binding_site_uniprot": 84, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 84, "end_pos": 84, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2#function" }, { "id": "A0AAA9SNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY2" }, { "id": "PIRSR605301-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR605301-1" } ], "binding_site_uniprot": 89, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 89, "end_pos": 89, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQA8-1", "uniprot_ac": "A0AAA9SQA8", "uniprot_id": "A0AAA9SQA8_BOVIN", "mass": { "chemical_mass": 99333.0, "monoisotopic_mass": 99333.0 }, "refseq": {}, "gene_names": [ { "name": "MACC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" } ] } ], "protein_names": [ { "name": "Metastasis-associated in colon cancer protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8/entry#names_and_taxonomy" } ] }, { "name": "SH3 domain-containing protein 7a5", "type": "synonym", "evidence": [ { "id": "A0AAA9SQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MACC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8", "locus": { "chromosome": "4", "start_pos": 28774234, "end_pos": 28886493, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003751", "url": "https://www.ensembl.org/id/ENSBTAG00000003751" } ] } } ], "crossref": [ { "id": "A0AAA9SQA8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003751", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003751", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01670", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01670", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521867", "url": "https://www.ncbi.nlm.nih.gov/gene/521867", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521867", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521867", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPMLNHD", "url": "https://omabrowser.org/oma/group/PPMLNHD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MV63", "url": "https://www.orthodb.org/?gene=F1MV63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15603:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15603:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MD41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MV63", "url": "https://www.uniprot.org/uniprotkb/F1MV63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MV63-1", "url": "https://www.uniprot.org/uniprotkb/F1MV63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTSEKAHFWSGGISRSMSEGNLFDMEARKSSRNCDITDPGLPLDWPEDFTLHGSNASSATNPFWNELSASNPFLDDITQLRNNQKRDNISILKEDPLLFFREIETGNSFDSSGDELDVHRLLRQSSSRKSGRSKSVSELLDILDNTAHAHQNIHNFDQILEQDLEWLRNDREAYKMAWLSHRHLARSCLDLSTINQSPGWAQTQVAETTVVCKLNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPQKLNHDLSCTISPLLEIMLGNLNTMEAILLEMKIGAEVKRDPFSQVMAEIVCLHSLDKEGPFKALNNCYIYKDTIQVKLVDLSQVMYLVVAAQTKGTQSPVATIWDYIHRTISVGIYGPKYIHPSFTAVFTVCGHSYMPGKLTISDIKKGGKPNTSPVVFQLWGKHSFLLEKPQDLNISVLSCDPDFEVKAERKRKEVKQKHLQSGQAVHQQFFFSLVDSREMHLFVFCVQVEPRSGRPVTQFFITSPDPAPNLKSLSNLPSDLQKKKEINSSPLLPTVHVKYPTFQDKKLNFTSYGITQKTVIRQNKIEYLLEYFKGDTVALLGEGKVKAIGQSKVKEWYVGVLRGKIGLLHCKNIRVIAKEQVMSMSDNVFTTRNLLEQITLPLKKLTYIYSVVLTLVSEKVYDWKVLAYVLGYSHLALEDFDQLQADKESEKVAYVVKKLKEDCHADRNARKFLYELTVALLKIDCQGLVVHLVQEAAILTSAVKLGKGWRELAEKLVRLTKRQMEAYEIPHQGKSGDLAVEMMWKPAYDFLYTWSAHYGNSYRDVLQDLQSALDRMKNPVTKQWRDLTGALILVPEGRYDWKSVVCIHQLEFLPPSSILRPPDQPLEKPVCRSGSNS", "length": 876, "header": "tr|A0AAA9SQA8-1|A0AAA9SQA8_BOVIN Isoform 1 of Metastasis-associated in colon cancer protein 1 OS=Bos taurus OX=9913 GN=MACC1 PE=4 SV=1 CANONICAL=A0AAA9SQA8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MD41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8/entry#A0A3Q1MD41-1", "sequence": { "sequence": "MLTSEKAHFWSGGISRSMSEGNLFDMEARKSSRNCDITDPGLPLDWPEDFTLHGSNASSATNPFWNELSASNPFLDDITQLRNNQKRDNISILKEDPLLFFREIETGNSFDSSGDELDVHRLLRQSSSRKSGRSKSVSELLDILDNTAHAHQNIHNFDQILEQDLEWLRNDREAYKMAWLSHRHLARSCLDLSTINQSPGWAQTQVAETTVVCKLNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPQKLNHDLSCTISPLLEIMLGNLNTMEAILLEMKIGAEVKRDPFSQVMAEIVCLHSLDKEGPFKALNNCYIYKDTIQVKLVDLSQVMYLVVAAQTKGTQSPVATIWDYIHRTISVGIYGPKYIHPSFTAVFTVCGHSYMPGKLTISDIKKGGKPNTSPVVFQLWGKHSFLLEKPQDLNISVLSCDPDFEVKAERKRKEVKQKHLQSGQAVHQQFFFSLVDSREMHLFVFCVQVEPRSGRPVTQFFITSPDPAPNLKSLSNLPSDLQKKKEINSSPLLPTVHVKYPTFQDKKLNFTSYGITQKTVIRQNKIEYLLEYFKGDTVALLGEGKVKAIGQSKVKEWYVGVLRGKIGLLHCKNIRVIAKEQVMSMSDNVFTTRNLLEQITLPLKKLTYIYSVVLTLVSEKVYDWKVLAYVLGYSHLALEDFDQLQADKESEKVAYVVKKLKEDCHADRNARKFLYELTVALLKIDCQGLVVHLVQEAAILTSAVKLGKGWRELAEKLVRLTKRQMEAYEIPHQGKSGDLAVEMMWKPAYDFLYTWSAHYGNSYRDVLQDLQSALDRMKNPVTKQWRDLTGALILVNSLEVLRATAFSTSEEV", "length": 850, "header": "tr|A0A3Q1MD41-1|A0AAA9SQA8_BOVIN Computationally mapped isoform of Metastasis-associated in colon cancer protein 1 OS=Bos taurus OX=9913 GN=MACC1 PE=4 SV=1 CANONICAL=A0AAA9SQA8-1" }, "locus": { "chromosome": "4", "start_pos": 28818615, "end_pos": 28791889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079446.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079446.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068823.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068823.1" } ] } }, { "isoform_ac": "A0AAA9SQA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8/entry#A0AAA9SQA8-1", "sequence": { "sequence": "MLTSEKAHFWSGGISRSMSEGNLFDMEARKSSRNCDITDPGLPLDWPEDFTLHGSNASSATNPFWNELSASNPFLDDITQLRNNQKRDNISILKEDPLLFFREIETGNSFDSSGDELDVHRLLRQSSSRKSGRSKSVSELLDILDNTAHAHQNIHNFDQILEQDLEWLRNDREAYKMAWLSHRHLARSCLDLSTINQSPGWAQTQVAETTVVCKLNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPQKLNHDLSCTISPLLEIMLGNLNTMEAILLEMKIGAEVKRDPFSQVMAEIVCLHSLDKEGPFKALNNCYIYKDTIQVKLVDLSQVMYLVVAAQTKGTQSPVATIWDYIHRTISVGIYGPKYIHPSFTAVFTVCGHSYMPGKLTISDIKKGGKPNTSPVVFQLWGKHSFLLEKPQDLNISVLSCDPDFEVKAERKRKEVKQKHLQSGQAVHQQFFFSLVDSREMHLFVFCVQVEPRSGRPVTQFFITSPDPAPNLKSLSNLPSDLQKKKEINSSPLLPTVHVKYPTFQDKKLNFTSYGITQKTVIRQNKIEYLLEYFKGDTVALLGEGKVKAIGQSKVKEWYVGVLRGKIGLLHCKNIRVIAKEQVMSMSDNVFTTRNLLEQITLPLKKLTYIYSVVLTLVSEKVYDWKVLAYVLGYSHLALEDFDQLQADKESEKVAYVVKKLKEDCHADRNARKFLYELTVALLKIDCQGLVVHLVQEAAILTSAVKLGKGWRELAEKLVRLTKRQMEAYEIPHQGKSGDLAVEMMWKPAYDFLYTWSAHYGNSYRDVLQDLQSALDRMKNPVTKQWRDLTGALILVPEGRYDWKSVVCIHQLEFLPPSSILRPPDQPLEKPVCRSGSNS", "length": 876, "header": "tr|A0AAA9SQA8-1|A0AAA9SQA8_BOVIN Isoform 1 of Metastasis-associated in colon cancer protein 1 OS=Bos taurus OX=9913 GN=MACC1 PE=4 SV=1 CANONICAL=A0AAA9SQA8-1" }, "locus": { "chromosome": "4", "start_pos": 28818615, "end_pos": 28788303, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098151.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098151.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086179.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086179.1" } ] } }, { "isoform_ac": "A0AAA9TEE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8/entry#A0AAA9TEE4-1", "sequence": { "sequence": "MLTSEKAHFWSGGISRSMSEGNLFDMEARKSSRNCDITDPGLPLDWPEDFTLHGSNASSATNPFWNELSASNPFLDDITQLRNNQKRDNISILKEDPLLFFREIETGNSFDSSGDELDVHRLLRQSSSRKSGRSKSVSELLDILDNTAHAHQNIHNFDQILEQDLEWLRNDREAYKMAWLSHRHLARSCLDLSTINQSPGWAQTQVAETTVVCKLNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPQKLNHDLSCTISPLLEIMLGNLNTMEAILLEMKIGAEVKRDPFSQVMAEIVCLHSLDKEGPFKALNNCYIYKDTIQVKLVDLSQVMYLVVAAQTKGTQSPVATIWDYIHRTISVGIYGPKYIHPSFTAVFTVCGHSYMPGKLTISDIKKGGKPNTSPVVFQLWGKHSFLLEKPQDLNISVLSCDPDFEVKAERKRKEVKQKHLQSGQAVHQQFFFSLVDSREMHLFVFCVQVEPRSGRPVTQFFITSPDPAPNLKSLSNLPSDLQKKKEINSSPLLPTVHVKYPTFQDKKLNFTSYGITQKTVIRQNKIEYLLEYFKGDTVALLGEGKVKAIGQSKVKEWYVGVLRGKIGLLHCKNIRVIAKEQVMSMSDNVFTTRNLLEQITLPLKKLTYIYSVVLTLVSEKVYDWKVLAYVLGYSHLALEDFDQLQADKESEKVAYVVKKLKEDCHADRNARKFLYELTVALLKIDCQGLVVHLVQEAAILTSAVKLGKGWRELAEKLVRLTKRQMEAYEIPHQGKSGDLAVEVMERPPGYCK", "length": 790, "header": "tr|A0AAA9TEE4-1|A0AAA9TEE4_BOVIN Computationally mapped isoform of Metastasis-associated in colon cancer protein 1 OS=Bos taurus OX=9913 GN=MACC1 PE=4 SV=1 CANONICAL=A0AAA9SQA8-1" }, "locus": { "chromosome": "4", "start_pos": 28818615, "end_pos": 28800425, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095286.1" } ] } }, { "isoform_ac": "F1MV63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8/entry#F1MV63-1", "sequence": { "sequence": "MLTSEKAHFWSGGISRSMSEGNLFDMEARKSSRNCDITDPGLPLDWPEDFTLHGSNASSATNPFWNELSASNPFLDDITQLRNNQKRDNISILKEDPLLFFREIETGNSFDSSGDELDVHRLLRQSSSRKSGRSKSVSELLDILDNTAHAHQNIHNFDQILEQDLEWLRNDREAYKMAWLSHRHLARSCLDLSTINQSPGWAQTQVAETTVVCKLNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPQKLNHDLSCTISPLLEIMLGNLNTMEAILLEMKIGAEVKRDPFSQVMAEIVCLHSLDKEGPFKALNNCYIYKDTIQVKLVDLSQVMYLVVAAQTKGTQSPVATIWDYIHRTISVGIYGPKYIHPSFTAVFTVCGHSYMPGKLTISDIKKGGKPNTSPVVFQLWGKHSFLLEKPQDLNISVLSCDPDFEVKAERKRKEVKQKHLQSGQAVHQQFFFSLVDSREMHLFVFCVQVEPRSGRPVTQFFITSPDPAPNLKSLSNLPSDLQKKKEINSSPLLPTVHVKYPTFQDKKLNFTSYGITQKTVIRQNKIEYLLEYFKGDTVALLGEGKVKAIGQSKVKEWYVGVLRGKIGLLHCKNIRVIAKEQVMSMSDNVFTTRNLLEQITLPLKKLTYIYSVVLTLVSEKVYDWKVLAYVLGYSHLALEDFDQLQADKESEKVAYVVKKLKEDCHADRNARKFLYELTVALLKIDCQGLVVHLVQEAAILTSAVKLGKGWRELAEKLVRLTKRQMEAYEIPHQGKSGDLAVEATYINNDNPLQYSCLENPMDGGA", "length": 803, "header": "tr|F1MV63-1|A0AAA9SQA8_BOVIN Computationally mapped isoform of Metastasis-associated in colon cancer protein 1 OS=Bos taurus OX=9913 GN=MACC1 PE=4 SV=3 CANONICAL=A0AAA9SQA8-1" }, "locus": { "chromosome": "4", "start_pos": 28818615, "end_pos": 28774282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004882.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004882.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004882.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004882.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521867", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521867", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LM16-1", "protein_name": "Metastasis-associated in colon cancer protein 1", "gene_name": "Macc1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLISERAYCWPRGIARSRSEGNLVDMEASKLSKNHNITACQGPGLPHNWPEASTHHGDSVAKATNPFWNELSASNPFLDDITQLRNNQKRDNKSILKEDPFLFLRQIETGNSFDSSGDELDIDQVLRPSSSRKSGRSKSVSELLDMLHDTTHTHQSMHISDQILIQDLEWLQNDREAYKMAWLSQRQLARSCLDLNMINQSPGWAQTQIAESIAVCKLNHQGGSVQLPESDITVHVPQGHIAVGEFQEVSLRAFLDPPPKLNHDHSCTVSPLLEIRLSNLKTMGAIMLEMKIGAEVKTDPLSQVMTKMVCLHSQSREGPFQAINNCYFYKDTIQAKFMDLSQIMYIIVAVQAKAIQPPATTVWDYIHKTTSIGIYGPKYIHPSFTAVFTVCGHNYMPGKFTVSDIRKGRKHTSPVVFHLWGKHSFLLDKPQDLIISAFSCDPDFEVKLEKERKIIAQRQLEAGAVVHQQVFFSSVDHREMHLFVFRVHVELPNGKPITQFFVTSPDPAPNLKRLSHLQSYFQKEREGKKVPLLSTGLAYYPTFQDKKVTFTNYGVTLKTVLRQRKIEYLLEYLKGDIIALLGEGTVRSIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMSLSDSILTTKNLLEQIALPFKNLTYIYSVVLTLVSENIHDWKVLANVLGYSHLAQEDFDQIEADKEPERVSYIVKKLKEDCHEDRSTRKFLYELIVALLKMDCQALVARLIQEAVILTSAVKLGRGWRELAEKSAGLTKHQMQAYEIPYRGKSGEVSAETMWKPAYDFLYAWSAHYGNSYRDVLQDLQSALDRMKNPVTKRWRDLTGTLILVNSLEVLRVTAFSTSQEI", "length": 852 }, "evidence": [ { "id": "A0AAA9SQA8", "url": "https://omabrowser.org/oma/group/A0AAA9SQA8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XL98-1", "protein_name": "Metastasis-associated in colon cancer protein 1", "gene_name": "MACC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEENASSNGTASLHNSEILRSRSEGTLIDVDDRIPSATYNVNESKMDLDIEWSDLFKHAHTVSKTNPFWNELSSSNPFVHDIAASNRNENNKYLSIMKEKSYLFSKVSSDGDSLASSGDELNIDCLLRRSSTRRSGRSKSVSDFLDIIDNRRFNPHKPTPQKTTVSDMACLQIDREAYKMAWLSHRQLTRSCLDLEAMSHSPGWAQTQATDVHVVCKLNHEGGSVQLPDSDINVHVPVGHVLPGEFQEVGLRAILNPPSSFNNELSSTVSPLIELTLSNLNTKEAIFLEVKVAAKVKNDPLSQVMSDIVCFFSLDKEGPFKKLENCYTYQDTIQVKLSDLSHVMYAVIAVQANKLQPPATNVWDYIHRTVSVGIYGPKYIHPSFTAVFAVFGHNYIPGKLTICDIKKGGKNMPPVVFQLWGKHTFLLEKPQDLSISLVSCDPDFEVKMEDEGKNIKEEELKTGEMVRQQFLFSMLGCREMHFFVFLVQIKVSKSSQVTQFHVTTPDPAPKLSGIISRTQRLQKRKEIKSAPLFLIPTVKYPKFQNKILNVNTYGVALKTVLRQNKIDYLLEYFKGDTIALLGEDKVKAIGQAKIKEWYVGVLRRKIGLVHCKNIKVISKEQAMDTTDSELTTRNLVEQITLPFKKLTYIYSVVLSTVSESVYDWRALAEVLGYSHISLDDFNEAHGDKESDRVAHVVKMLKEDCHANKKKRLFLYELIIALLKIDCQGLVARLTQDTIILTSAVKLGKYWRELAEKLARLTKQQIEAYEVPHQGKSGAVALEMMWKPAYDFLYTWAAHYGDSYRDVLQDLQSALDKMKNPVTKQWRELTGALILVNCMEVLRASAFSRMEEEN", "length": 853 }, "evidence": [ { "id": "A0AAA9SQA8", "url": "https://omabrowser.org/oma/group/A0AAA9SQA8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AB32T3T1-1", "protein_name": "Metastasis-associated in colon cancer protein 1 isoform X1", "gene_name": "macc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAAKIKSNSHPANLLRSRSEGTLIDIDENVTINNNNLHGGCGYEIGKTSEWPVIQKEIENPKQTTNPFWNQLGRSNPFLNEIVHTSNYDSGVSMMKEDPASLFDSINEDSLSTSSDETNFAHLLAPRQNNLNRSGRWRSASDILESLEKKEDKRAVKLSSKESFLNPDFEWLKNDREAYKMAWLSHRQLTRSCLDLSLMKQSPGWAQTQATDIQIFCKIDHNGGSVQLPESDITAHIPHGHVPPGEVQDIALKVHLDPPPGINNNYTTTLSPLLEVKLSNSNISGGISVEMRMAAKVKNDPTSHVLTSFMGLVSQRKEGPYQKIKDCYIYNDMLQMKLFDLKPHMYVITAAEATVLESPAVSVWDYLDRQITVAVYGPKHIHPSLKVVLVIMSHNNIAPRLPFSDIQRGNRNLPPVVLELWGRHQFNPQGLKDLHIVSRVLDLNFEVKPEDQNKEIKQKQLEDGKVHHLPLDLVKVGGGEMSAFKLSIEVKDSNSLTLGDFYVASPEAAPLRSEKYNHRRVDWQKEAIRSSPIPEESIPEILSQKFQDRPVDLHWYGVAMKSVLRQPRVEYLLEYFKGDTIALLSKETVRSVGHMKVKEWYIGFLRGRVGLVHCKNLKIITKDQVIDFTGIHLTTPVLLDNMTVPFKKLTYMYSAIQTLVTEHVKCWRNFAEALGYSEVSVDAISRRHAETEAEKVACVLEKLKEDCHAEKNKKKFQHELIIGLLKMDAQGLVAHLIQDIVILSTAVELGVRWRELAERLGKISSAQIAVYEAPHKGKNGEVSTQSMWKPAYDFLFAWSKRYGDSYRDMIQDLHLALDKMKSPVTKQWRQITGALITINSMEVLRTYAFNRVLDLL", "length": 857 }, "evidence": [ { "id": "A0AAA9SQA8", "url": "https://omabrowser.org/oma/group/A0AAA9SQA8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9PXX8-1", "protein_name": "Metastasis-associated in colon cancer protein 1", "gene_name": "Macc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLISERAYCWPREIGRSRSEGNLIDMEASKRSKNQNITARQGLGLPHNWPDAPTLHRDSDAKATNPFWKELSASNPFLEDITQLRNNKKRDNMSILKEDPFLFLRQIETENSFDSSGDELDMDQGFKSSSSRKSGRSKSVSELLDVLGDRTHTHQSIHSSDQILIQDLEWLQNDREAYKMAWLSQRQLARSCLDLNTINQSPGWAQTQIAETIAVCKLNHQGGSVQLPDSDITIHIPQGHIAVGEFQEVSLRAFLDPPPKLNHDLSCTVSPLLEIRLSNLNTMEAILLEMKTGAEVKTDPLSQVMTKMVCLYSLDREGPFQALNTCYIYKDTIQAKLLDLSHVMYIVIAVQATIIHPPAATIWDYIHKTTSIGIYGPKYLHPSFTAVFTVCGHNYVPGKFTVSDIRKGGKNTSPVVFHLWGKHSFSLDKPKDLIISAFSCDPDFEVKEEGERKVIAQRQLEAGVVVHQQVFFSSIDHREMHLFVFRVQVKTPNEKPVTQFFVTSPDPSPNLKRFSYLPGFFQKREDKRVPLLSTGLVKYPTFQDKKLNFTNYGVALKTVLRQNKIDYLLEYLKGDTIALLGEGTVRAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMSMSDGILTTKNLLEQIALPFKSLTYIYSVVLTLVSEKVHDWKVLANVLGYSHLAQEDFNRIQADKEPERVSYVVKKLKEDCHEDRNTRKFLYELIVALLKMDCQELVAHLIQEAVILTSAVKLGRSWRELAEKSAGLTKHQMQAYEIPHRGKSGDVSAEMMWKPAYDFLYAWSFHYGNSYRDVLQDLQSALDRMKNPVTKRWRDLTGTLILINSLEILRVTAFSTSQEI", "length": 851 }, "evidence": [ { "id": "A0AAA9SQA8", "url": "https://omabrowser.org/oma/group/A0AAA9SQA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZN28-1", "protein_name": "Metastasis-associated in colon cancer protein 1", "gene_name": "MACC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLITERKHFRSGRIAQSMSEANLIDMEAGKLSKSCNITECQDPDLLHNWPDAFTLRGNNASKVANPFWNQLSASNPFLDDITQLRNNRKRNNISILKEDPFLFCREIENGNSFDSSGDELDVHQLLRQTSSRNSGRSKSVSELLDILDDTAHAHQSIHNSDQILLHDLEWLKNDREAYKMAWLSQRQLARSCLDLNTISQSPGWAQTQLAEVTIACKVNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPHMLNHDLSCTVSPLLEIMLGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPFKVLSNCYIYKDTIQVKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSFTVVLTVCGHNYMPGQLTISDIKKGGKNISPVVFQLWGKQSFLLDKPQDLSISIFSCDPDFEVKTEGERKEIKQKQLEAGEVVHQQFLFSLVEHREMHLFDFCVQVEPPNGEPVAQFSITTPDPTPNLKRLSNLPGYLQKKEEIKSAPLSPKILVKYPTFQDKTLNFSNYGVTLKAVLRQSKIDYFLEYFKGDTIALLGEGKVKAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMFMSDSVFTTRNLLEQIVLPLKKLTYIYSVVLTLVSEKVYDWKVLADVLGYSHLSLEDFDQIQADKESEKVSYVIKKLKEDCHTERNTRKFLYELIVALLKMDCQELVARLIQEAAVLTSAVKLGKGWRELAEKLVRLTKQQMEAYEIPHRGNTGDVAVEMMWKPAYDFLYTWSAHYGNNYRDVLQDLQSALDRMKNPVTKHWRELTGVLILVNSLEVLRVTAFSTSEEV", "length": 852 }, "evidence": [ { "id": "A0AAA9SQA8", "url": "https://omabrowser.org/oma/group/A0AAA9SQA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 547, "end_pos": 549, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA8" }, { "id": "PS51145", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZU5", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 346, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 526, "end_pos": 528 }, { "start_pos": 547, "end_pos": 549 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ88-1", "uniprot_ac": "A0AAA9SQ88", "uniprot_id": "A0AAA9SQ88_BOVIN", "mass": { "chemical_mass": 132763.0, "monoisotopic_mass": 132763.0 }, "refseq": { "ac": "XP_005208268", "name": "AF4/FMR2 family member 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208268" }, "gene_names": [ { "name": "AFF1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ] }, { "name": "AFF1", "type": "synonym", "evidence": [ { "id": "XP_005208268", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208268" } ] } ], "protein_names": [ { "name": "AF4/FMR2 family member 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208268", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208268" } ] }, { "name": "ALF transcription elongation factor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AFF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88", "locus": { "chromosome": "6", "start_pos": 102045732, "end_pos": 101859046, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018488", "url": "https://www.ensembl.org/id/ENSBTAG00000018488" } ] } } ], "crossref": [ { "id": "A0AAA9SQ88", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ88", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018488", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018488", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781149", "url": "https://www.ncbi.nlm.nih.gov/gene/781149", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KFTMSLK", "url": "https://omabrowser.org/oma/group/KFTMSLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MG66", "url": "https://www.orthodb.org/?gene=A0A3Q1MG66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BHU6", "url": "https://www.orthodb.org/?gene=E1BHU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10528", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10528", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10528:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10528:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18875", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18875", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18876", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18876", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208268", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208268", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHU6", "url": "https://www.uniprot.org/uniprotkb/E1BHU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BHU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFTERVNSSSNSSLYNEDRNLLRIREKERRNQEAHQDKEAFSEKIPLFGEPYKTEKGDELSSRIQNMLGNYEEMKEFLSSKSHPQRLDASENRLGKPRYPLFPEKGSSLPPHSFHTSVHHQPVNTPACGPHPAGNIGHHPKMAQPRMEPMPSLHAKSYGPPDSQHLTQERLGQEGYGSSHHKKGDRRADGDHCALTTDSAPERELSPLFSLPSPVPPLSPVHSNQQTAPRTQGSGKVPSSSSSNKGYCLAKSPKDLAVKVHDKETPQDSTGAVASLGVAPPQPPSQTFPPPSLPSKSLAMQQKPTAYVRPMDGQDQAPSESPELKPLPEEYRQQTFEKSDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHISSAVPNQKQYDTSSKTHSNSQQGTSMLKDDLQLSDSEDSDSDQTSEKPPFAPAPPSAPPALPAAAASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPREAPAPEPEPPTTNKWQLDNWLTKVSQPAVPTEAPGSTEPPARPPDTKGKGGDSATAGHERPESKEPPPKGSSKAPRVPSEGPHAGKRSCQKSPTQQEPPQRQTVGSKQPKKPIKASAPGHADAPADARACLQVESEPGLPPPASRDQPSKDKPKVKTKGRPRAADSREPKPAVPTPSDRKKHRSGPPKAPPKDAAAEDRSPEHFALVPLTQSQGPVRGGSGGAGARTSGCRLAVVVQEDRRKDKPPVPSRDTKLLSPLRDAPPPQSLVVKITLDLLSRIPQPPGKGSRPKKPEDKQPPAGKKPDPEKRSSENASKLAKKRKGEAEKDHDSKKVRLEKEVKSQPLSSSSHKESSKSKMSRPSSEPSKKEMLPPSLVSSSSSQKPAKPAQKRPRQEDPGCQDPQKSAGSAKGSHRDPSASKHRKAEGKVSGSSTEHKGSSGDTANRFPVPSLPNGNSKPGKPHVKFDKQQADFHLKEAKRLKDKAELVTDKVGKAFKYLEAALSFIECGVALESESPASKSAYSIYSETVDLIKFILSLKSFSDATTPTQEKIFAVLCMRCQSILNMAMFRCKKDMAIKYSRTLNEHFFKTSSKVAQAPSPCIARSTGTPSPLSPIPSPASSIGSQSSAGSVGSGALPATISTPVTIQNMTSSYVSITSHVLTAFDLWEQAEVLTRKNKEFFAQLSTSVCALALNSSLMDLVHYTRQGFQRLKQVTKTP", "length": 1229, "header": "tr|A0AAA9SQ88-1|A0AAA9SQ88_BOVIN Isoform 1 of ALF transcription elongation factor 1 OS=Bos taurus OX=9913 GN=AFF1 PE=3 SV=1 CANONICAL=A0AAA9SQ88-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MG66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88/entry#A0A3Q1MG66-1", "sequence": { "sequence": "MAFTERVNSSSNSLYNEDRNLLRIREKERRNQEAHQDKEAFSEKIPLFGEPYKTEKGDELSSRIQNMLGNYEEMKEFLSSKSHPQRLDASENRLGKPRYPLFPEKGSSLPPHSFHTSVHHQPVNTPACGPHPAGNIGHHPKMAQPRMEPMPSLHAKSYGPPDSQHLTQERLGQEGYGSSHHKKGDRRADGDHCALTTDSAPERELSPLFSLPSPVPPLSPVHSNQQTAPRTQGSGKVPSSSSSNKGYCLAKSPKDLAVKVHDKETPQDSTGAVASLGVAPPQPPSQTFPPPSLPSKSLAMQQKPTAYVRPMDGQDQAPSESPELKPLPEEYRQQTFEKSDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHISSAVPNQKQYDTSSKTHSNSQQGTSMLKDDLQLSDSEDSDSDQTSEKPPFAPAPPSAPPALPAAAASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPREAPAPEPEPPTTNKWQLDNWLTKVSQPAVPTEAPGSTEPPARPPDTKGKGGDSATAGHERPESKEPPPKGSSKAPRVPSEGPHAGKRSCQKSPTQQEPPQRQTVGSKQPKKPIKASAPGHADAPADARACLQVESEPGLPPPASRDQPSKDKPKVKTKGRPRAADSREPKPAVPTPSDRKKHRSGPPKAPPKDAAAEDRSPEHFALVPLTQSQGPVRGGSGGAGARTSGCRLAVVVQEDRRKDKPPVPSRDTKLLSPLRDAPPPQSLVVKITLDLLSRIPQPPGKGSRPKKPEDKQPPAGKKPDPEKRSSENASKLAKKRKGEAEKDHDSKKVRLEKEVKSQPLSSSSHKESSKSKMSRPSSEPSKKEMLPPSLVSSSSSQKPAKPAQKRPRQEDPGCQDPQKSAGSAKGSHRDPSASKHRKAEGKVSGSSTEHKGSSGDTANRFPVPSLPNGNSKPGKPHVKFDKQQADFHLKEAKRLKDKAELVTDKVGKAFKYLEAALSFIECGVALESESPASKSAYSIYSETVDLIKFILSLKSFSDATTPTQEKIFAVLCMRCQSILNMAMFRCKKDMAIKYSRTLNEHFFKTSSKVAQAPSPCIARSTGTPSPLSPIPSPASSIGSQSSAGSVGSGALPATISTPVTIQNMTSSYVSITSHVLTAFDLWEQAEVLTRKNKEFFAQLSTSVCALALNSSLMDLVHYTRQGFQRLKQVTKTP", "length": 1228, "header": "tr|A0A3Q1MG66-1|A0AAA9SQ88_BOVIN Computationally mapped isoform of ALF transcription elongation factor 1 OS=Bos taurus OX=9913 GN=AFF1 PE=3 SV=1 CANONICAL=A0AAA9SQ88-1" }, "locus": { "chromosome": "6", "start_pos": 102044605, "end_pos": 101865945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070038.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070038.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069534.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069534.1" } ] } }, { "isoform_ac": "A0AAA9SQ88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88/entry#A0AAA9SQ88-1", "sequence": { "sequence": "MAFTERVNSSSNSSLYNEDRNLLRIREKERRNQEAHQDKEAFSEKIPLFGEPYKTEKGDELSSRIQNMLGNYEEMKEFLSSKSHPQRLDASENRLGKPRYPLFPEKGSSLPPHSFHTSVHHQPVNTPACGPHPAGNIGHHPKMAQPRMEPMPSLHAKSYGPPDSQHLTQERLGQEGYGSSHHKKGDRRADGDHCALTTDSAPERELSPLFSLPSPVPPLSPVHSNQQTAPRTQGSGKVPSSSSSNKGYCLAKSPKDLAVKVHDKETPQDSTGAVASLGVAPPQPPSQTFPPPSLPSKSLAMQQKPTAYVRPMDGQDQAPSESPELKPLPEEYRQQTFEKSDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHISSAVPNQKQYDTSSKTHSNSQQGTSMLKDDLQLSDSEDSDSDQTSEKPPFAPAPPSAPPALPAAAASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPREAPAPEPEPPTTNKWQLDNWLTKVSQPAVPTEAPGSTEPPARPPDTKGKGGDSATAGHERPESKEPPPKGSSKAPRVPSEGPHAGKRSCQKSPTQQEPPQRQTVGSKQPKKPIKASAPGHADAPADARACLQVESEPGLPPPASRDQPSKDKPKVKTKGRPRAADSREPKPAVPTPSDRKKHRSGPPKAPPKDAAAEDRSPEHFALVPLTQSQGPVRGGSGGAGARTSGCRLAVVVQEDRRKDKPPVPSRDTKLLSPLRDAPPPQSLVVKITLDLLSRIPQPPGKGSRPKKPEDKQPPAGKKPDPEKRSSENASKLAKKRKGEAEKDHDSKKVRLEKEVKSQPLSSSSHKESSKSKMSRPSSEPSKKEMLPPSLVSSSSSQKPAKPAQKRPRQEDPGCQDPQKSAGSAKGSHRDPSASKHRKAEGKVSGSSTEHKGSSGDTANRFPVPSLPNGNSKPGKPHVKFDKQQADFHLKEAKRLKDKAELVTDKVGKAFKYLEAALSFIECGVALESESPASKSAYSIYSETVDLIKFILSLKSFSDATTPTQEKIFAVLCMRCQSILNMAMFRCKKDMAIKYSRTLNEHFFKTSSKVAQAPSPCIARSTGTPSPLSPIPSPASSIGSQSSAGSVGSGALPATISTPVTIQNMTSSYVSITSHVLTAFDLWEQAEVLTRKNKEFFAQLSTSVCALALNSSLMDLVHYTRQGFQRLKQVTKTP", "length": 1229, "header": "tr|A0AAA9SQ88-1|A0AAA9SQ88_BOVIN Isoform 1 of ALF transcription elongation factor 1 OS=Bos taurus OX=9913 GN=AFF1 PE=3 SV=1 CANONICAL=A0AAA9SQ88-1" }, "locus": { "chromosome": "6", "start_pos": 102044605, "end_pos": 101865945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124992.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124992.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086103.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086103.1" } ] } }, { "isoform_ac": "E1BHU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88/entry#E1BHU6-1", "sequence": { "sequence": "MAAQSSSLYNEDRNLLRIREKERRNQEAHQDKEAFSEKIPLFGEPYKTEKGDELSSRIQNMLGNYEEMKEFLSSKSHPQRLDASENRLGKPRYPLFPEKGSSLPPHSFHTSVHHQPVNTPACGPHPAGNIGHHPKMAQPRMEPMPSLHAKSYGPPDSQHLTQERLGQEGYGSSHHKKGDRRADGDHCALTTDSAPERELSPLFSLPSPVPPLSPVHSNQQTAPRTQGSGKVPSSSSSNKGYCLAKSPKDLAVKVHDKETPQDSTGAVASLGVAPPQPPSQTFPPPSLPSKSLAMQQKPTAYVRPMDGQDQAPSESPELKPLPEEYRQQTFEKSDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHISSAVPNQKQYDTSSKTHSNSQQGTSMLKDDLQLSDSEDSDSDQTSEKPPFAPAPPSAPPALPAAAASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPREAPAPEPEPPTTNKWQLDNWLTKVSQPAVPTEAPGSTEPPARPPDTKGKGGDSATAGHERPESKEPPPKGSSKAPRVPSEGPHAGKRSCQKSPTQQEPPQRQTVGSKQPKKPIKASAPGHADAPADARACLQVESEPGLPPPASRDQPSKDKPKVKTKGRPRAADSREPKPAVPTPSDRKKHRSGPPKAPPKDAAAEDRSPEHFALVPLTQSQGPVRGGSGGAGARTSGCRLAVVVQEDRRKDKPPVPSRDTKLLSPLRDAPPPQSLVVKITLDLLSRIPQPPGKGSRPKKPEDKQPPAGKKPDPEKRSSENASKLAKKRKGEAEKDHDSKKVRLEKEVKSQPLSSSSHKESSKSKMSRPSSEPSKKEMLPPSLVSSSSSQKPAKPAQKRPRQEDPGCQDPQKSAGSAKGSHRDPSASKHRKAEGKVSGSSTEHKGSSGDTANRFPVPSLPNGNSKPGKPHVKFDKQQADFHLKEAKRLKDKAELVTDKVGKAFKYLEAALSFIECGVALESESPASKSAYSIYSETVDLIKFILSLKSFSDATTPTQEKIFAVLCMRCQSILNMAMFRCKKDMAIKYSRTLNEHFFKTSSKVAQAPSPCIASTGTPSPLSPIPSPASSIGSQSSAGSVGSGALPATISTPVTIQNMTSSYVSITSHVLTAFDLWEQAEVLTRKNKEFFAQLSTSVCALALNSSLMDLVHYTRQGFQRLKQVTKTP", "length": 1221, "header": "tr|E1BHU6-1|A0AAA9SQ88_BOVIN Computationally mapped isoform of ALF transcription elongation factor 1 OS=Bos taurus OX=9913 GN=AFF1 PE=3 SV=4 CANONICAL=A0AAA9SQ88-1" }, "locus": { "chromosome": "6", "start_pos": 102044605, "end_pos": 101908763, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024607.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024607.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024607.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024607.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 687, "start_aa": "Thr", "end_pos": 687, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr687", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZBU5-1", "protein_name": "ALF transcription elongation factor 1", "gene_name": "Aff1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFKDSSSSSLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFAEPYKTAKGDELSSRIQTMLGDYEEMKEFLSSKSHPHRLDGSEDRPGKPRYPSCHDRGSGASGSFRTHVYHQPTHTSAPGSLSVSNVSQSPKMAQPRMEPVPSLHAKIYGAPDGPRPAQDRLSQGHCSRKCDRRAEGDSERKLSPFISSLPSPVPPLSPAHSRPQATSKAHGSGTGTQSCYASKPSKDPVVTAQEKETPLDSLVAVTSLGAAPPQPPCQTFPPPPLPSKSIAMQQKPTAYVRPMDGQDQAPSESPELKPPLEDFGQQSFEKPDLKVPAKAKLTRLRMPSQTVEQPYSNEVHCVEEILKEMTHSWPSPLTAIHTPSTAEPSRFPFPTKDPLHISSATQSQKQYDAPSKTHPNPQQGTSMLEDDLQLSDSEESDVEQAVEKPPSPPAPPSAPQTIPEPVASAHSSSAESESSESDSSSDSESESSSSDSEENEPLETQAPEPEPPTTNKWQLDNWLTKVNQPSVPLESRGSTESPRCRQESKGGGEGGSDQQHPDSKDPPLKSSSKALRGPSEGPQPGKRNCPKSPAQQETPPPRQTVGSKQPRKPTKGSTQAEQPQASSRVEGEAGPVAYGSKEQTSKDKPKVKTKGRPRAVGSREPKSEVPVPVPQAAVPKPQPPAPTPIEKRKHKSSTAPSKALSGPQPTKDSAGDRNQEHPALVSLTQSQGQPNSGRGSGGGRTSGCRQAVITQEDSCRDKLLLPLRDTKLLSPLRDSPPPTSLVVKITLDLLTRVPQPPGKGGRPRKSEHKQLPAGKKQDLEARGCDSSSRVTKKRKAEPEKEHSHKRLRLDKSQTSSSSSSHAESSKSKTPRPSSECSRKEMLPPPPVVPSSSSSSSSSQKPSKPAHKRPRPDADIGSQDPPRSSGSTKSSCTDSSVPKHRKVQARDSEHKGSSGDAANPFPVPSLPNGNSKPGKPQVKSDRQQADFHMKEAKKLKCKAEAMVDKAGKAFKYLEAVLSFIECGMATESESSAKSAYTVYSETVDLIKFVMSLKSFSDNTVPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFRSTSKVAQAPSPCVARSTGVPSPVSPMPSPASSAGSQTSAGSSMGAMGATATVSTPVTIQNMTSSYVTITSHVLKAFTLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVHYTRQGLQRLRQAPQTPLM", "length": 1223 }, "evidence": [ { "id": "A0AAA9SQ88", "url": "https://omabrowser.org/oma/group/A0AAA9SQ88/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O88573-1", "protein_name": "AF4/FMR2 family member 1", "gene_name": "Aff1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAHSSLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYKTAKGDELSSRIQTMLGDYEEMKEFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAASSSLRTHVYHQPIHTSAPGSRPVGNISHSPKMAQPRMEPSLHTKIYDGPRLTQDHLSQGHCSRKCDRRAEGDSAPERKLSPLISSLPSPVPPLSPVHSRLQGTSKAHSSGVSSKSCCVAKSSKDLVAKAQDKETPHDGLVAVTSLGSAPPQPPCQTFPPPPLPSKSAAMQQKPTAYVRPMDGQDQAPSESPELKLPLEDYGQQSFEKPDLKVPAKAKLTRLRMPSQSVEQPYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSRFPFPTKDPLHVSPATQSQKQYDTPSKTHPNPQQGTSMLEDDLQLSDSEDSDTEQATEKPPSPPAPPSAPQTLPEPVASAHSSSGESESSESDSSSDSESESSSSDSEEEEENEPLETRAPEPEPPTTNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSDQQHPDSKDPLPKSSSKTLRGPSEGPSLGRGAVRNPPLNRNPHLGKPWAANNPGNPPRLRPGRAQASSQAESEVGPLPYGSKEQTSKDRPKVKTKGRPRAVGSREPKPEVPAPTPQAAVPRPKPPVPTPSEKRKHKSSTAPSKAPSAPQPPKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRTSGCRQAVIAQGDGCKDKLLLPLRDTKLLSPLRDSPPPTSLVVKITLDLLTRIPQPLGKGSRPRKAEDKQLSAGKKQDSETKSCDSSSRVTKKRKVTQKKSTVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRPAQKRPRPDEDTCSQEPPRSASSTKSSSTDPPAPKHRKVQARGSEHKGSSGDAANAANPFPVPSLPNGNAKPGKPQVKSDRQQADFHMKEAKKLKCKAETMVDKAGKAFKYLEAVLSFIECGMASESESSAKSAYAVYSETIDLIRYVMSLKCFSDNTMPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFKSTSKVAQAPSPCTARSTGVPSPLSPMPSPASSVGSQSSAGSSMGSVGVTATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVHYTRQGLQRLKQSPKGP", "length": 1216 }, "evidence": [ { "id": "A0AAA9SQ88", "url": "https://omabrowser.org/oma/group/A0AAA9SQ88/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P51825-1", "protein_name": "AF4/FMR2 family member 1", "gene_name": "AFF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP", "length": 1210 }, "evidence": [ { "id": "A0AAA9SQ88", "url": "https://omabrowser.org/oma/group/A0AAA9SQ88/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" }, { "name": "nervous system process", "id": "GO:0050877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050877", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" }, { "name": "DNA-templated transcription elongation", "id": "GO:0006354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006354", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "super elongation complex", "id": "GO:0032783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" }, { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1159, "end_pos": 1161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1205, "end_pos": 1207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 824, "end_pos": 826, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ88" }, { "id": "PF18876", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18876" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AF4/FMR2 C-terminal homology", "eco_id": "ECO_0000259", "start_pos": 966, "end_pos": 1228, "start_aa": "Asn", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 687 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1159, "end_pos": 1161 }, { "start_pos": 1205, "end_pos": 1207 }, { "start_pos": 12, "end_pos": 14 }, { "start_pos": 824, "end_pos": 826 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNR3-1", "uniprot_ac": "A0AAA9SNR3", "uniprot_id": "A0AAA9SNR3_BOVIN", "mass": { "chemical_mass": 98377.0, "monoisotopic_mass": 98377.0 }, "refseq": {}, "gene_names": [ { "name": "TTC7A", "type": "recommended", "evidence": [ { "id": "A0AAA9SNR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat protein 7A", "type": "recommended", "evidence": [ { "id": "A0AAA9SNR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSG0#function" }, { "database": "UniProtKB", "id": "ARBA00054379", "url": "https://www.uniprot.org/uniprotkb/ARBA00054379#function" }, { "database": "UniProtKB", "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3", "locus": { "chromosome": "11", "start_pos": 29525964, "end_pos": 29405121, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032558", "url": "https://www.ensembl.org/id/ENSBTAG00000032558" } ] } } ], "crossref": [ { "id": "A0AAA9SNR3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032558", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032558", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MSG0", "url": "https://www.orthodb.org/?gene=A0A3Q1MSG0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDL2", "url": "https://www.orthodb.org/?gene=E1BDL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23083:SF475", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23083:SF475", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T507", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T507", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T507-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T507-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL2", "url": "https://www.uniprot.org/uniprotkb/E1BDL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGDSGNLATSYNPQNNVSKVGIYRGGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTYHEAWQGLGEVLEAQGQSEAAVDCFLTALELEASSPVLPFSIIPREL", "length": 882, "header": "tr|A0AAA9SNR3-1|A0AAA9SNR3_BOVIN Isoform 1 of Tetratricopeptide repeat protein 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=1 CANONICAL=A0AAA9SNR3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MSG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#A0A3Q1MSG0-1", "sequence": { "sequence": "MEKTLMLERLGAGGEENEMAGWHHRLDGHDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTYHEAWQGLGEVLEAQGQSEAAVDCFLTALELEASSPVLPFSIIPREL", "length": 825, "header": "tr|A0A3Q1MSG0-1|A0AAA9SNR3_BOVIN Computationally mapped isoform of Tetratricopeptide repeat protein 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=2 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29525517, "end_pos": 29412000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071008.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071008.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072982.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072982.2" } ] } }, { "isoform_ac": "A0AAA9SNR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#A0AAA9SNR3-1", "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGDSGNLATSYNPQNNVSKVGIYRGGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTYHEAWQGLGEVLEAQGQSEAAVDCFLTALELEASSPVLPFSIIPREL", "length": 882, "header": "tr|A0AAA9SNR3-1|A0AAA9SNR3_BOVIN Isoform 1 of Tetratricopeptide repeat protein 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=1 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29525517, "end_pos": 29405199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117241.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117241.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085590.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085590.1" } ] } }, { "isoform_ac": "A0AAA9T507-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#A0AAA9T507-1", "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTYHEAWQGLGEVLEAQGQSEAAVDCFLTALELEASSPVLPFSIIPREL", "length": 813, "header": "tr|A0AAA9T507-1|A0AAA9T507_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=1 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29525517, "end_pos": 29405199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121678.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121678.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093868.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093868.1" } ] } }, { "isoform_ac": "A0AAA9TT16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#A0AAA9TT16-1", "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLVAQWQRIRLPCRSRKFSP", "length": 803, "header": "tr|A0AAA9TT16-1|A0AAA9TT16_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=1 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29518287, "end_pos": 29405199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102505.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102505.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100207.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100207.1" } ] } }, { "isoform_ac": "A0AAA9TV70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#A0AAA9TV70-1", "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLIPCFKNSLRSTAVKVSLMSAPWTTR", "length": 810, "header": "tr|A0AAA9TV70-1|A0AAA9TV70_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=1 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29515756, "end_pos": 29405199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101779.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101779.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100480.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100480.1" } ] } }, { "isoform_ac": "A0AAA9TWN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#A0AAA9TWN7-1", "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLCGSQAKFRCSWFAEGRGCPESSLRHSL", "length": 812, "header": "tr|A0AAA9TWN7-1|A0AAA9TWN7_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=1 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29519733, "end_pos": 29405199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093222.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093222.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101580.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101580.1" } ] } }, { "isoform_ac": "E1BDL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3/entry#E1BDL2-1", "sequence": { "sequence": "MAAKGAYGSHLKMESELERCRAEGHWDRMPELVRQMQALVVLGGGGGRRGSPSAGFTSLDTDDLGKLLLAEALLEQCLKGNHATIKDSIPLLEKNEPKMNEARNHLSSILNHGKLPPQYLCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLAEAFVIKGLSLERLPNSIASRPRLTEREEEVITCFERASWIAQVFLQELEKVTSNTTSRHLKGSHPVDYELTYFLEAALQSAYVTNLKKGNIVKGMKELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWNPLSQPLPEFMSKEENSFITQALRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRTPEQEEDRAVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSSYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLHWLEEAERFAMMVIHLGEEAGEFLSKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPGDPQVILYVSLQLALVRQISSAMEQLQEALKVCKDDANALHLLALLFSAQKHYQHALDVINMAITEYPENFNLMFTKVKLEQVLKGPEEALVTCRQMLQLWQTLYSFSQLGGLEKDGSLGEGLTLKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTVPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEADFCIQEAAGLFPTSHSVLYMRGRLAEMKGSLEEAKQLYKEALTVNPDGVRIMHSLVAADTPGRIWRAGEGLGLAGT", "length": 806, "header": "tr|E1BDL2-1|A0AAA9SNR3_BOVIN Computationally mapped isoform of Tetratricopeptide repeat protein 7A OS=Bos taurus OX=9913 GN=TTC7A PE=4 SV=2 CANONICAL=A0AAA9SNR3-1" }, "locus": { "chromosome": "11", "start_pos": 29521551, "end_pos": 29405199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046196.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046196.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043517.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043517.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 654, "end_pos": 656, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR3" }, { "id": "PF19440", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19440" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetratricopeptide repeat protein 7 N-terminal", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 403, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 220, "end_pos": 222 }, { "start_pos": 654, "end_pos": 656 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQA3-1", "uniprot_ac": "A0AAA9SQA3", "uniprot_id": "A0AAA9SQA3_BOVIN", "mass": { "chemical_mass": 78471.0, "monoisotopic_mass": 78471.0 }, "refseq": {}, "gene_names": [ { "name": "SYBU", "type": "recommended", "evidence": [ { "id": "A0AAA9SQA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ] } ], "protein_names": [ { "name": "Syntabulin", "type": "synonym", "evidence": [ { "id": "A0AAA9SQA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYBU", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3", "locus": { "chromosome": "14", "start_pos": 54833681, "end_pos": 54745443, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032548", "url": "https://www.ensembl.org/id/ENSBTAG00000032548" } ] } } ], "crossref": [ { "id": "A0AAA9SQA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032548", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032548", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618577", "url": "https://www.ncbi.nlm.nih.gov/gene/618577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EHSKRTI", "url": "https://omabrowser.org/oma/group/EHSKRTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR16208", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16208", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16208:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16208:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15290", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15290", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MVX8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVX8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S532", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S532", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S532-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S532-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFI7", "url": "https://www.uniprot.org/uniprotkb/F1MFI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZF5", "url": "https://www.uniprot.org/uniprotkb/G3MZF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZF5-1", "url": "https://www.uniprot.org/uniprotkb/G3MZF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLCQACSSGLPGVRVGADPPRLSGEVPPPGRRQRRREEPAGGSAMGPLRETKKELRVQHHEKEIARSRIPRLILRPHLPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEDCTRKKCTIGMVGEGSLQSARHKKEPKSGLVKPAHRVRCVSRAQSTLVNLNSKGSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 730, "header": "tr|A0AAA9SQA3-1|A0AAA9SQA3_BOVIN Isoform 1 of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=1 CANONICAL=A0AAA9SQA3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#A0A3Q1MVX8-1", "sequence": { "sequence": "MMRKAEPSYPELRVQHHEKEIARSRIPRLILRPHLPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEDCTRKKCTIGMVGEGSLQSARHKKEPKSGLVKPGSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 667, "header": "tr|A0A3Q1MVX8-1|A0AAA9SQA3_BOVIN Computationally mapped isoform of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=1 CANONICAL=A0AAA9SQA3-1" }, "locus": { "chromosome": "14", "start_pos": 54832925, "end_pos": 54750541, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080997.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080997.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059373.1" } ] } }, { "isoform_ac": "A0AAA9S532-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#A0AAA9S532-1", "sequence": { "sequence": "MGPLRETKKELRVQHHEKEIARSRIPRLILRPHLPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEDCTRKKCTIGMVGEGSLQSARHKKEPKSGLVKPAHRVRCVSRAQSTLVNLNSKGSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 686, "header": "tr|A0AAA9S532-1|A0AAA9SQA3_BOVIN Computationally mapped isoform of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=2 CANONICAL=A0AAA9SQA3-1" }, "locus": { "chromosome": "14", "start_pos": 54832925, "end_pos": 54749424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117496.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117496.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080292.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080292.2" } ] } }, { "isoform_ac": "A0AAA9SA54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#A0AAA9SA54-1", "sequence": { "sequence": "MLCQACSSGLPGVRVGADPPRLSGEVPPPGRRQRRREEPAGGSAMGPLRETKELRVQHHEKEIARSRIPRLILRPHLPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEDCTRKKCTIGMVGEGSLQSARHKKEPKSGLVKPGSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 709, "header": "tr|A0AAA9SA54-1|A0AAA9SQA3_BOVIN Computationally mapped isoform of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=1 CANONICAL=A0AAA9SQA3-1" }, "locus": { "chromosome": "14", "start_pos": 54832925, "end_pos": 54748770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090106.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090106.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079047.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079047.1" } ] } }, { "isoform_ac": "A0AAA9SQA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#A0AAA9SQA3-1", "sequence": { "sequence": "MLCQACSSGLPGVRVGADPPRLSGEVPPPGRRQRRREEPAGGSAMGPLRETKKELRVQHHEKEIARSRIPRLILRPHLPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEDCTRKKCTIGMVGEGSLQSARHKKEPKSGLVKPAHRVRCVSRAQSTLVNLNSKGSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 730, "header": "tr|A0AAA9SQA3-1|A0AAA9SQA3_BOVIN Isoform 1 of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=1 CANONICAL=A0AAA9SQA3-1" }, "locus": { "chromosome": "14", "start_pos": 54832925, "end_pos": 54748770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091896.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091896.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088512.1" } ] } }, { "isoform_ac": "F1MFI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#F1MFI7-1", "sequence": { "sequence": "MKVYGAYLLSSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 533, "header": "tr|F1MFI7-1|A0AAA9SQA3_BOVIN Computationally mapped isoform of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=3 CANONICAL=A0AAA9SQA3-1" }, "locus": { "chromosome": "14", "start_pos": 54832925, "end_pos": 54789261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046186.3", "url": "https://www.ensembl.org/id/ENSBTAT00000046186.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043508.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043508.3" } ] } }, { "isoform_ac": "G3MZF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3/entry#G3MZF5-1", "sequence": { "sequence": "MGPLRETKELRVQHHEKEIARSRIPRLILRPHLPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEDCTRKKCTIGMVGEGSLQSARHKKEPKSGLVKPAHRVRCVSRAQSTLVNLNSKGSEADFSSSSSTGSISAPEVPMSAAGSKRSSFSRNRGPHGRSNGASSYKSANSPPSPREKDLLAMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGLLRDELCLDFPCESPEKGLALGAALGPTEGALSPEEPATEEGADSELLGADGAAPGEDVLEELVTGAIPEPELPGAEVVALGGEAAAVGRGGRRAVAERAVQTDVVPYSPAFSELLRHVLRLQDPWPSSSAATPDEESGDDSTESFPEPISTFVVDLTPRNPNSAILLSPVETPSPAAGPEARGNRLMRELDFAGSEAAAAEEEVRLDGPGPLARAGGIAGRYWSRSFLVDLLAVGAPVVPTVLWAFSTQRGGTDPLYNIGALLRGCCVVALHSLRRTTEHIKT", "length": 685, "header": "tr|G3MZF5-1|G3MZF5_BOVIN Computationally mapped isoform of Syntabulin OS=Bos taurus OX=9913 GN=SYBU PE=4 SV=2 CANONICAL=A0AAA9SQA3-1" }, "locus": { "chromosome": "14", "start_pos": 54832925, "end_pos": 54749424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065047.2", "url": "https://www.ensembl.org/id/ENSBTAT00000065047.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054952.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054952.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 474, "start_aa": "Thr", "end_pos": 474, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr474", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 579, "start_aa": "Thr", "end_pos": 579, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr579", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NVV7-1", "protein_name": "Syntabulin", "gene_name": "SYBU", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGPLRESGKEEQKAHPEKEVSRSRIPRLVLRPQPPQQHKVSPASESPFSEEESREFNPPSSSGGSARTISSNSFCSDDTGCPSSQSVSPVKTPSDAGHSPISFCTGSDGDFSRKKFNAGTMSEGNSQLARYKKETKTILVKPGSEADFSSSSSTGSISAPEVHMSAPGSKRSSFSRNRGPYGRNSGSSSYKSGASPPASREKDHLSTLCRSQQNPVNIHQNYGVSSPSSSNSGSYKGSDTSPIMRRSGRYLTCVDHHSAKPQNPEQYLTPLQQKEVTVRHLKTKLKESQSKLKERETEIEELKTQLGRMREDWIEEECHRVEAQLALKEAKKEIKQLKQVIETMKNNLAEKDKGIQKYFIDINIQNKKLESLLHSMEMAQNGSLRDEDVSDAPGKPLALYAKLPDTLITEEQALEVDSGVLLNEDIANGNDSFQETFTTAGVELADPAFFISAVDQEVLENVPDEKLRSSRKEERSDIVMVEQSVQTDVVPYSLNVERLIQNIFGSQDVSPLSPPSSLKELSDFSSGSFSDSAIVVDLTPSDPNSAILLSPMESPCRKVDYGVDENRVMKELDFTEMRDEVFGYVNNSSETGVMQRHWSGSLLVDLLAVAAPVVPTVMWVFSTQRGGVDPIYNIGALLRGCCLVALHSLRRTPFNIRT", "length": 658 }, "evidence": [ { "id": "A0AAA9SQA3", "url": "https://omabrowser.org/oma/group/A0AAA9SQA3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6A508-1", "protein_name": "Syntabulin", "gene_name": "Sybu", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPYLPVQSLRPPAPVPTCSEAPGAAALAPEAKRPRGPERAGGCRTTCANPAGAGGAGRGWLLQPQRKPVATRRVAGRRPSPTQASRAFRHTVWTAQWTRSAKETVPPPGRRRRRGEPAGNDEMGPLRESKKEQRVQHQEKEFSRSRIPRLILRPHLPQQQQQQQNKVSPASESPFSEEESREFNPSSSGRSARTISSNSFCSDDTGCPSSQSVSPVKTPSDTGHSPIGFCPGSDEDFTRKKCRIGMVGEGNIQSARYKKESKGGIIKPGSEADFSSSSSTGSISAPEVHMSTTGNKRASFSRNRGPHGRSNGAPSHKSGSSPPSPREKDLVSMLCRNPLSPSNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDELCLDFSFDSPEKSLPLSSTYDKMADGLSLEEQITEEGADSELLVGDSMAEGTDLLDEIVTATTTESGDLEFVHSTPGPQALKPLPLVSQEEGIVVVEQAVQTDVVPFSPAISELLQSVLKLQDSCPTSSASPDESGADSMESFSESISALMVDLTPRSPNSAILLSPVEIPFSKAATEARANRLMRELDFAACTEERLDSILSLSQGGVVRQYWSSSFLVDLLAVAAPVVPTVLWVFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT", "length": 788 }, "evidence": [ { "id": "A0AAA9SQA3", "url": "https://omabrowser.org/oma/group/A0AAA9SQA3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHS8-1", "protein_name": "Syntabulin", "gene_name": "Sybu", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPLRESKKEQRVQHQEKEISRSRIPRLILRPHRPQQQQQQQNKVSPASESPFSEEESREFNPSSSGRSARTISSNSFCSDDTGCPSSQSVSPVKTPSDTGHSPIGFCPGSDEDFTRKKCRIGMVGEGSIQSARHKKEPKGGIIKPGSEADFSSSSSTGSISAPEVHMSTTGNKRASFSRNRGPHGRSNGASSHKSGSSPPSPREKDLVSMLCRNPLSPSNIHPSYAPSSPSSSNSGSYKGSDCSPVMRRSGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLRTKLKESERRLHERESEIMELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHNSSLRDELCLDFSFDSPEKSLPLSSTFDKLPDGLSLEEQITEEGADSELLVGDSMAEGTDLLDEMVTATTTESSGLEFVHSTPGPQALKALPLVSHEEGIAVMEQAVQTDVVPFSPAISELIQSVLKLQDYCPTSSASPDESGADSMESFSESISALMLDLTPRSPNSAILLSPVEIPFSKGAMEAHANRLMRELDFAAYTEERLDSVLSLSQGSVVRQYWSSNFLVDLLAVAAPVVPTVLWAFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFHMKT", "length": 665 }, "evidence": [ { "id": "A0AAA9SQA3", "url": "https://omabrowser.org/oma/group/A0AAA9SQA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX95-1", "protein_name": "Syntabulin", "gene_name": "SYBU", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPLRESKKEHRVQHHDKEISRSRIPRLILRPHMPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSEADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLSLEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQSVLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLARGGVVRQYWSSSFLVDLLAVAAPVVPTVLWAFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFRIKT", "length": 663 }, "evidence": [ { "id": "A0AAA9SQA3", "url": "https://omabrowser.org/oma/group/A0AAA9SQA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "synapse maturation", "id": "GO:0060074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060074", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" }, { "name": "axonal transport of mitochondrion", "id": "GO:0019896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019896", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 474, 579 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPF9-1", "uniprot_ac": "A0AAA9SPF9", "uniprot_id": "A0AAA9SPF9_BOVIN", "mass": { "chemical_mass": 207533.0, "monoisotopic_mass": 207533.0 }, "refseq": {}, "gene_names": [ { "name": "ANK1", "type": "recommended", "evidence": [ { "id": "A0AAA9SPF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ] } ], "protein_names": [ { "name": "Ankyrin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9SPF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#names_and_taxonomy" } ] }, { "name": "Erythrocyte ankyrin", "type": "synonym", "evidence": [ { "id": "A0AAA9SPF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NCL2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCL2#function" }, { "database": "UniProtKB", "id": "ARBA00058177", "url": "https://www.uniprot.org/uniprotkb/ARBA00058177#function" }, { "database": "UniProtKB", "id": "A0AAA9S685", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S685#function" }, { "database": "UniProtKB", "id": "A0AAA9SMN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN0#function" }, { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9#function" }, { "database": "UniProtKB", "id": "A0AAA9TY46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY46#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9", "locus": { "chromosome": "27", "start_pos": 36565865, "end_pos": 36810546, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054394", "url": "https://www.ensembl.org/id/ENSBTAG00000054394" } ] } } ], "crossref": [ { "id": "ENSBTAG00000027629", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027629", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000054394", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054394", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08805", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08805", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "353108", "url": "https://www.ncbi.nlm.nih.gov/gene/353108", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ADEDHFM", "url": "https://omabrowser.org/oma/group/ADEDHFM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N1N9", "url": "https://www.orthodb.org/?gene=A0A3Q1N1N9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24123:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24123:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00531", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00531", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17809", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17809", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N1N9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1N9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCL2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCL2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S685", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S685", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S685-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S685-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q6C1", "url": "https://www.uniprot.org/uniprotkb/F6Q6C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q6C1-1", "url": "https://www.uniprot.org/uniprotkb/F6Q6C1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHLRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESGLTPLHVASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMTKKGFTPLHVAAKYGKVRMAELLLEHDAHPNAAGKSGLTPLHVAVHHNHLDVVRLLLPRGGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETTVQLITDKHRMSFPETVDEILDVSEDEGEDLGPRAERPDARDVDEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRADEPDQVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQFLSPVIVEIPHFASQGRGDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLRCYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFLFQSFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERRRTLTPLALRYSLLESTADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINRIRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRSLKPDRRPADRDYSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAIPLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGHERQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVSWAMDSSQDRVHDWDAEGSIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPGPAAEQSEVGREQRPPSPQEWTQEAGSTVSLQGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKVVRQIDPSGADDTQELEEVISKGPLEDPSEMEADIDSFMTHAKDHTSTPNP", "length": 1892, "header": "tr|A0AAA9SPF9-1|A0AAA9SPF9_BOVIN Isoform 1 of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N1N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#A0A3Q1N1N9-1", "sequence": { "sequence": "MWTFVTQLLVTLVLLGFFLVSCQNVAHIVRGSLGFMLKHVHQELDKELGESEGLSDDEETISTRVVRRRVLLKGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKVVRQIDPSGADDTQELEEVISKGPLEDPSEMEADIDSFMTHAKDHTSTPNP", "length": 156, "header": "tr|A0A3Q1N1N9-1|A0AAA9SPF9_BOVIN Computationally mapped isoform of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36576268, "end_pos": 36566924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066510.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066510.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063016.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063016.1" } ] } }, { "isoform_ac": "A0A3Q1NCL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#A0A3Q1NCL2-1", "sequence": { "sequence": "MAARQGRSGPDAAADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHLRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESGLTPLHVASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMTKKGFTPLHVAAKYGKVRMAELLLEHDAHPNAAGKSGLTPLHVAVHHNHLDVVRLLLPRGGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETTVQLITDKHRMSFPETVDEILDVSEDEGTAHITIMGEDLGPRAERPDARDVDEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRADEPDQVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQFLSPVIVEIPHFASQGRGDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLRCYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFLFQSFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERRRTLTPLALRYSLLESTADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINRIRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRSLKPDRRPADRDYSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAIPLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGHERQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVSWAMDSSQDRVHDWDAEGSIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPGPAAEQSEVGREQRPPSPQEWTQEAGSTVSLQVKIVRKVVRQIDPSGADDTQELEEVISKGPLEDPSEMEDHTSTPNP", "length": 1834, "header": "tr|A0A3Q1NCL2-1|A0AAA9SPF9_BOVIN Computationally mapped isoform of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=2 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36674696, "end_pos": 36566924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085365.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085365.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069149.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069149.2" } ] } }, { "isoform_ac": "A0AAA9S685-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#A0AAA9S685-1", "sequence": { "sequence": "MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHLRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESGLTPLHVASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMTKKGFTPLHVAAKYGKVRMAELLLEHDAHPNAAGKSGLTPLHVAVHHNHLDVVRLLLPRGGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETTVQLITDKHRMSFPETVDEILDVSEDEGTAHITIMGEDLGPRAERPDARDVDEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRADEPDQVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQFLSPVIVEIPHFASQGRGDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLRCYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFLFQSFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERRRTLTPLALRYSLLESTADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINRIRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRSLKPDRRPADRDYSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAIPLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGHERQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVSWAMDSSQDRVHDWDAEGSIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPGPAAEQSEVGREQRPPSPQEWTQEAGSTVSLQVKGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKVVRQIDPSGADDTQELEEDHTSTPNP", "length": 1877, "header": "tr|A0AAA9S685-1|A0AAA9SPF9_BOVIN Computationally mapped isoform of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36809373, "end_pos": 36566924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088384.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088384.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080719.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080719.1" } ] } }, { "isoform_ac": "A0AAA9SMN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#A0AAA9SMN0-1", "sequence": { "sequence": "MAARQGRSGPDAAADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHLRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESGLTPLHVASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMTKKGFTPLHVAAKYGKVRMAELLLEHDAHPNAAGKSGLTPLHVAVHHNHLDVVRLLLPRGGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETTVQLITDKHRMSFPETVDEILDVSEDEGEDLGPRAERPDARDVDEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRADEPDQVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQFLSPVIVEIPHFASQGRGDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLRCYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFLFQSFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERRRTLTPLALRYSLLESTADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINRIRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRSLKPDRRPADRDYSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAIPLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGHERQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVSWAMDSSQDRVHDWDAEGSIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPGPAAEQSEVGREQRPPSPQEWTQEAGSTVSLQGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKVVRQIDPSGADDTQELEEDHTSTPNP", "length": 1838, "header": "tr|A0AAA9SMN0-1|A0AAA9SPF9_BOVIN Computationally mapped isoform of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36674696, "end_pos": 36566924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089658.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089658.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085223.1" } ] } }, { "isoform_ac": "A0AAA9SPF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#A0AAA9SPF9-1", "sequence": { "sequence": "MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHLRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESGLTPLHVASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMTKKGFTPLHVAAKYGKVRMAELLLEHDAHPNAAGKSGLTPLHVAVHHNHLDVVRLLLPRGGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETTVQLITDKHRMSFPETVDEILDVSEDEGEDLGPRAERPDARDVDEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRADEPDQVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQFLSPVIVEIPHFASQGRGDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLRCYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFLFQSFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERRRTLTPLALRYSLLESTADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINRIRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRSLKPDRRPADRDYSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAIPLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGHERQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVSWAMDSSQDRVHDWDAEGSIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPGPAAEQSEVGREQRPPSPQEWTQEAGSTVSLQGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKVVRQIDPSGADDTQELEEVISKGPLEDPSEMEADIDSFMTHAKDHTSTPNP", "length": 1892, "header": "tr|A0AAA9SPF9-1|A0AAA9SPF9_BOVIN Isoform 1 of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36809373, "end_pos": 36566924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084800.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084800.1" } ] } }, { "isoform_ac": "A0AAA9TY46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#A0AAA9TY46-1", "sequence": { "sequence": "MHFPGFGRADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHLRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKMGASIDAVTESGLTPLHVASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALALLEKEASQTCMTKKGFTPLHVAAKYGKVRMAELLLEHDAHPNAAGKSGLTPLHVAVHHNHLDVVRLLLPRGGSPHSPALNGYTPLHIAAKQNQLEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETTVQLITDKHRMSFPETVDEILDVSEDEGEDLGPRAERPDARDVDEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRADEPDQVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQFLSPVIVEIPHFASQGRGDRELVVLRSENGSVWKEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIGPEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLRCYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFLFQSFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERRRTLTPLALRYSLLESTADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINRIRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRSLKPDRRPADRDYSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAIPLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGPQGPTLGSLDLVEDDTVDSDATNGLIDLLDQEEGQRSEEKLPGHERQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVSWAMDSSQDRVHDWDAEGSIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPGPAAEQSEVGREQRPPSPQEWTQEAGSTVSLQVKGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKVVRQIDPSGADDTQELEEVELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ", "length": 1859, "header": "tr|A0AAA9TY46-1|A0AAA9TY46_BOVIN Computationally mapped isoform of Ankyrin-1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36707571, "end_pos": 36573596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108550.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108550.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103574.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103574.1" } ] } }, { "isoform_ac": "F6Q6C1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9/entry#F6Q6C1-1", "sequence": { "sequence": "MWTFVTQLLVTLVLLGFFLVSCQNVAHIVRGSLGFMLKHVHQELDKELGESEGLSDDEETISTRVVRRRVLLKGNELQNIPGEQVTEEHFTDEQGNVITKKDHTSTPNP", "length": 109, "header": "tr|F6Q6C1-1|F6Q6C1_BOVIN Computationally mapped isoform of Ankyrin 1 OS=Bos taurus OX=9913 GN=ANK1 PE=4 SV=1 CANONICAL=A0AAA9SPF9-1" }, "locus": { "chromosome": "27", "start_pos": 36576268, "end_pos": 36566924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004244.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004244.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004244.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004244.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0AC58JII7-1", "protein_name": "Ankyrin-1", "gene_name": "ank1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAQAAKHLRKNKDLEALAEQERKEKEEEKSKKRSRSREKKRKAHVVHRWLIDQDNSVSSELPDGQGVWHYDETADAATSFLRAARSGNLEKALDHIKNGIDINTANQNGLNGLHLASKEGHVKMVLELLHHGIVLETTTKKGNTALHIAALAGQEQVVTELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLDNGANQTIPTEDGFTPLAVALQQGHENVVALLINHGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGADVNFTPKNGITPLHIASRRGNVIMVRLLLDRGAKIDAKTKDELTPLHCAARNGHVRIIEILLDQGAPIQAKTKNGLSPIHMAAQGDHLDCIRQLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNTRALNGFTPLHIACKKNHMRVMDLLLKHSASLEAVTESGLTPLHVSSFMGHLNIVKILMQKGASPNASNVKVETPLHMASRAGHCEVAEFLLQNAAPVDAKAKDDQTPLHCASRMGHNEMVKLLLEHKANSNSTTTAGHTPLHIAAREGHTQTASILLDMNAQLTKMTKKGFTPLHVAAKYGKVDVAVLLLERGANPNAAGKVGLTPLHVAVHHNNLDVVNLLLSKGGSPHSAARNGYTPLHIASKQNQAEVASSLLQHGASANAESLQGVTPLHLASQEGQPDMVLLLISKQANVNLGNKSGLTPLHLVAQEGHVGIADILVKHGASVYAATRMGYTPLHVACHYGNIKMVKFLLQQQANVNCKTRMSYTPLHQAAQQGHTDIVTLLLKHGAQPNEVTSNGTSALAIAKRLGYISVIDVLKLVTEETVTMTTTEKHRMSFPETVDEILDVSEDEGIAQLTLGEELLGNEGARYLMKMEDIKDHDEDFLSPKKVLENHSPAIPRIPCVSPETVMLKEHEMEQQHTPLPLPKEYDEDSLIPSSPATETSDNVSPVASPIHTGFLVSFMVDARGGSMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLPTPPPLVEGEGLASRIISLGPASMQFLGPVIVEIPHFAALGRGDRELVVLRSENGSVWKEHRNRYGDEVLETILNGMDEDLESQEELGKKRIRRIISTDFPLYFAVVSRIQQENDLIGPEGGFLSSKLVPMVQATFPETAVTKRVRLGLQAQPVPDELVAKLLGNQATFSPVVTVEPRRRKFHRPIGLRIPLPPSWRESPRDAGEGDTTSLRLLCSVIGGTAPAQWEDITGTTKLAYSNDCASFTTNVSARFWLADCPRTAEAVSFANLLYRELSAVPYMAKFVVFAKMNEAREGRLRCYCMTDDKMDKTLEQHENFSEVARSRDIEVMEGMPLYLECSGNLVPIRKAAQQPRCFSFQAFKDNRLPVSVKVRDSSKDPSGFLSFLRKSTKYEDSQHVLCNLNVTMPPCIKIMGSDERRRTLTPLALRERYSALNEPAMASLSAMERTELKMALIAEQLGLSWAELGRELQFNVDEINKIRVENPNSLLEQSSTLLNLWAAREGKRAKMDSLYVALKSIDRVDIVNMMEGQGGPPAGQQGGWEQDASRSRHHDRDHLSPGITNGYGLVVQEELVSPASMQYSLPSPLGNEPYWQEVSSMECAPIATTEEDTLMEMSEVQVWPSGNSPSIVAVEDSSLECSNADDSEALQNRSLGHSRSGTPGGNGLTPGGLSGSIELLEDQSIGADSDYSAAGMLRLSEGVNISALDRGQGLESSEGAVGHQVTNNIKDGSNGGLGEGGGDGTQLEDSISLISGQQRVYARMSESPGLRRRADPGEDRLSAGSFLSYLQDQGSPGWHSAAEATQNRLASLQCSLPRQAIESMMSSVRATVDSDSKQSCLGQEALIEPVRDMGHSEIIHGHYQGTQPFEKGLGFPHRTTNMRAWEDMRLSGQGDEAEDLPGEQVSEEQFTDEHGNIVTKKIVRKVVRRGKGEEGGQELIIEGLQQDISEPDFDGEQFMSYAVLGRDSKPDVVDVKRGGAQIVKCASLRRVKQ", "length": 2027 }, "evidence": [ { "id": "A0AAA9SPF9", "url": "https://omabrowser.org/oma/group/A0AAA9SPF9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "spectrin-associated cytoskeleton", "id": "GO:0014731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "sarcoplasmic reticulum", "id": "GO:0016529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016529", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "ankyrin-1 complex", "id": "GO:0170014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170014", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "spectrin binding", "id": "GO:0030507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "cytoskeletal anchor activity", "id": "GO:0008093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008093", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" }, { "name": "protein phosphatase binding", "id": "GO:0019903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1045, "end_pos": 1047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1238, "end_pos": 1240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1392, "end_pos": 1394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" }, { "start_pos": 799, "end_pos": 801, "annotation": "n_glycosylation_sequon" }, { "start_pos": 933, "end_pos": 935, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" }, { "id": "PS50017", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50017" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Death", "eco_id": "ECO_0000259", "start_pos": 1434, "end_pos": 1518, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SPF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF9" }, { "id": "PS51145", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZU5", "eco_id": "ECO_0000259", "start_pos": 945, "end_pos": 1100, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1045, "end_pos": 1047 }, { "start_pos": 1238, "end_pos": 1240 }, { "start_pos": 1392, "end_pos": 1394 }, { "start_pos": 266, "end_pos": 268 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 698, "end_pos": 700 }, { "start_pos": 799, "end_pos": 801 }, { "start_pos": 933, "end_pos": 935 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRA6-1", "uniprot_ac": "A0AAA9SRA6", "uniprot_id": "A0AAA9SRA6_BOVIN", "mass": { "chemical_mass": 63740.0, "monoisotopic_mass": 63740.0 }, "refseq": {}, "gene_names": [ { "name": "GGN", "type": "recommended", "evidence": [ { "id": "A0AAA9SRA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6" } ] } ], "protein_names": [ { "name": "Gametotin", "type": "synonym", "evidence": [ { "id": "A0AAA9SRA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GGN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6", "locus": { "chromosome": "18", "start_pos": 48188882, "end_pos": 48197740, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005363", "url": "https://www.ensembl.org/id/ENSBTAG00000005363" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005363", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005363", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100140305", "url": "https://www.ncbi.nlm.nih.gov/gene/100140305", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140305", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140305", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPGQMHS", "url": "https://omabrowser.org/oma/group/PPGQMHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJE5", "url": "https://www.orthodb.org/?gene=E1BJE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47742:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47742:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RSQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T885", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T885", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T885-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T885-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE5", "url": "https://www.uniprot.org/uniprotkb/E1BJE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASDRSSDSRRTSLVEPEVTPSSPAMRLARGLGVWFPGSSAPPGLLVPPEPQASPSPLPLTLELPSPVTPPSEEAAAAAVSTPPPPPVGTLLPAPSKWRKPMGTPVPRIRGLLEASHRGQGDPPSLRPLPPPSLQLAEEDPDPVPRAPSPTPPPLEPRKPPLPPPSDGQHPDRRITPALATPAATPTESQARLGSEGQTASGARSGAPPQAGEGEMARPAASESGLSLLCKVTFKSGPPLPPAAASSSLATKASLGGGGGGGGLFAASGAISYAEVLKQGPLAPGASRPSGEVPRATQEAEGGDGDGEGCSGPPSASASHARTLPPPPYTTFPGSKPKFDWVSPPDGPERHFRFNGAGGGVGAPRRRAAAFSGPWGSAPPASGQMHPAPGSRRPAPALLAPPMFIFPAPTNGEPVRPRPPGPPELMPPPPPTPPPTPPPAPPPTPQPPVIQTTPLPVTLPPAPGPGHLESAVTPAPAPSLSSALAADQAQVPAPAPAPAPAPAPSPAPAPTVAEPLPPAPAPAKTRTRRNKGPRAARAVPREDGAPRDGPRERTATTVTDSGGAGGGGSGALPAGTANSGAARHWPPFQVLNSCPCKCYCRHQPRHRRLPRNVSAW", "length": 633, "header": "tr|A0AAA9SRA6-1|A0AAA9SRA6_BOVIN Isoform 1 of Gametotin OS=Bos taurus OX=9913 GN=GGN PE=4 SV=1 CANONICAL=A0AAA9SRA6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6/entry#A0AAA9RSQ0-1", "sequence": { "sequence": "MRPRTTRSGGRGRRHRSISKGDPEMGNVQSEPSAGGGSRKEQASDRSSDSRRTSLVEPEVTPSSPAMRLARGLGVWFPGSSAPPGLLVPPEPQASPSPLPLTLELPSPVTPPSEEAAAAAVSTPPPPPVGTLLPAPSKWRKPMGTPVPRIRGLLEASHRGQGDPPSLRPLPPPSLQLAEEDPDPVPRAPSPTPPPLEPRKPPLPPPSDGQHPDRRITPALATPAATPTESQARLGSEGQTASGARSGAPPQAGEGEMARPAASESGLSLLCKVTFKSGPPLPPAAASSSLATKASLGGGGGGGGLFAASGAISYAEVLKQGPLAPGASRPSGEVPRATQEAEGGDGDGEGCSGPPSASASHARTLPPPPYTTFPGSKPKFDWVSPPDGPERHFRFNGAGGGVGAPRRRAAAFSGPWGSAPPASGQMHPAPGSRRPAPALLAPPMFIFPAPTNGEPVRPRPPGPPELMPPPPPTPPPTPPPAPPPTPQPPVIQTTPLPVTLPPAPGPGHLESAVTPAPAPSLSSALAADQAQVPAPAPAPAPAPAPSPAPAPTVAEPLPPAPAPAKTRTRRNKGPRAARAVPREDGAPRDGPRERTATTVTDSGGAGGGGSGALPAGTANSGAARHWPPFQVLNSCPCKCYCRHQPRHRRLPRNVSAW", "length": 657, "header": "tr|A0AAA9RSQ0-1|A0AAA9SRA6_BOVIN Computationally mapped isoform of Gametotin OS=Bos taurus OX=9913 GN=GGN PE=4 SV=1 CANONICAL=A0AAA9SRA6-1" }, "locus": { "chromosome": "18", "start_pos": 48196596, "end_pos": 48193626, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122669.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122669.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075706.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075706.1" } ] } }, { "isoform_ac": "A0AAA9SRA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6/entry#A0AAA9SRA6-1", "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASDRSSDSRRTSLVEPEVTPSSPAMRLARGLGVWFPGSSAPPGLLVPPEPQASPSPLPLTLELPSPVTPPSEEAAAAAVSTPPPPPVGTLLPAPSKWRKPMGTPVPRIRGLLEASHRGQGDPPSLRPLPPPSLQLAEEDPDPVPRAPSPTPPPLEPRKPPLPPPSDGQHPDRRITPALATPAATPTESQARLGSEGQTASGARSGAPPQAGEGEMARPAASESGLSLLCKVTFKSGPPLPPAAASSSLATKASLGGGGGGGGLFAASGAISYAEVLKQGPLAPGASRPSGEVPRATQEAEGGDGDGEGCSGPPSASASHARTLPPPPYTTFPGSKPKFDWVSPPDGPERHFRFNGAGGGVGAPRRRAAAFSGPWGSAPPASGQMHPAPGSRRPAPALLAPPMFIFPAPTNGEPVRPRPPGPPELMPPPPPTPPPTPPPAPPPTPQPPVIQTTPLPVTLPPAPGPGHLESAVTPAPAPSLSSALAADQAQVPAPAPAPAPAPAPSPAPAPTVAEPLPPAPAPAKTRTRRNKGPRAARAVPREDGAPRDGPRERTATTVTDSGGAGGGGSGALPAGTANSGAARHWPPFQVLNSCPCKCYCRHQPRHRRLPRNVSAW", "length": 633, "header": "tr|A0AAA9SRA6-1|A0AAA9SRA6_BOVIN Isoform 1 of Gametotin OS=Bos taurus OX=9913 GN=GGN PE=4 SV=1 CANONICAL=A0AAA9SRA6-1" }, "locus": { "chromosome": "18", "start_pos": 48195524, "end_pos": 48193626, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132321.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132321.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097228.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097228.1" } ] } }, { "isoform_ac": "A0AAA9T885-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6/entry#A0AAA9T885-1", "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASDRSSDSRRTSLVEPEVTPSSPAMRLARGLGVWFPGSSAPPGLLVPPEPQASPSPLPLTLELPSPVTPPSEEAAAAAVSTPPPPPVGTLLPAPSKWRKPMGTPVPRIRGLLEASHRGQGDPPSLRPLPPPSLQLAEEDPDPVPRAPSPTPPPLEPRKPPLPPPSDGQHPDRRITPALATPAATPTESQARLGSEGQTASGARSGAPPQAGEGEMARPAASESGLSLLCKVTFKSGPPLPPAAASSSLATKASLGGGGGGGGLFAASGAISYAEVLKQGPLAPGASRPSGEVPRATQEAEGGDGDGEGCSGPPSASASHARTLPPPPYTTFPGSKPKFDWVSPPDGPERHFRFNGAGGGVGAPRRRAAAFSGPWGSAPPASGQMHPAPGSRRPAPALLAPPMFIFPAPTNGEPVRPRPPGPPELMPPPPPTPPPTPPPAPPPTPQPPVIQTTPLPVTLPPAPGPGHLESAVTPAPAPSLSSALAADQAQVPAPAPAPAPAPAPSPAPAPTVAEPLPPAPAPAKTRTRRNKGPRAARAVPREDGAPRDGPRERTATTVTDSGGAGGGGSGALPAGTANSGAARHWPPFQVLNSCPCKCYCRHQPRHRRLPRNVSAWLSTPTNHLSEPPWVATIKLAGSLVAGLEHYDLQATHSN", "length": 671, "header": "tr|A0AAA9T885-1|A0AAA9T885_BOVIN Computationally mapped isoform of Gametotin OS=Bos taurus OX=9913 GN=GGN PE=4 SV=1 CANONICAL=A0AAA9SRA6-1" }, "locus": { "chromosome": "18", "start_pos": 48195524, "end_pos": 48192639, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109987.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109987.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094172.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094172.1" } ] } }, { "isoform_ac": "E1BJE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6/entry#E1BJE5-1", "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASDRSSDSRRTSLVEPEVTPSSPAMRLARGLGVWFPGSSAPPGLLVPPEPQASPSPLPLTLELPSPVTPPSEEAAAAAVSTPPPPPVGTLLPAPSKWRKPMGTPVPRIRGLLEASHRGQGDPPSLRPLPPPSLQLAEEDPDPVPRAPSPTPPPLEPRKPPLPPPSDGQHPDRRITPALATPAATPTESQARLGSEGQTASGARSGAPPQAGEGEMARPAASESGLSLLCKVTFKSGPPLPPAAASSSLATKASLGGGGGGGGLFAASGAISYAEVLKQGPLAPGASRPSGEVPRATQEAEGGDGDGEGCSGPPSASASHARTLPPPPYTTFPGSKPKFDWVSPPDGPERHFRFNGAGGGVGAPRRRAAAFSGPWGSAPPASGQMHPAPGSRRPAPALLAPPMFIFPAPTNGEPVRPRPPGPPELMPPPPPTPPPTPPPAPPPTPQPPVIQTTPLPVTLPPAPGPGHLESAVTPAPAPSLSSALAADQAQVPAPAPAPAPAPAPSPAPAPTVAEPLPPAPAPAKTRTRRNKGPRAARAVPREDGAPRDGPRERTATTVTDSGGAGGGGSGALPAGTANSGAARHWPPFQVLNSCPCKCYCRHQPRHRRLPRNVSA", "length": 632, "header": "tr|E1BJE5-1|A0AAA9SRA6_BOVIN Computationally mapped isoform of Gametotin OS=Bos taurus OX=9913 GN=GGN PE=4 SV=4 CANONICAL=A0AAA9SRA6-1" }, "locus": { "chromosome": "18", "start_pos": 48195524, "end_pos": 48193629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044856.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044856.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042309.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042309.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 168, "start_aa": "Thr", "end_pos": 168, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr168", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 198, "start_aa": "Thr", "end_pos": 198, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr198", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 37, "start_aa": "Thr", "end_pos": 37, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr37", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 449, "start_aa": "Thr", "end_pos": 449, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr449", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 453, "start_aa": "Thr", "end_pos": 453, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr453", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 461, "start_aa": "Thr", "end_pos": 461, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr461", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 490, "start_aa": "Thr", "end_pos": 490, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr490", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 528, "start_aa": "Thr", "end_pos": 528, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr528", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 86, "start_aa": "Thr", "end_pos": 86, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr86", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100140305", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140305", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A569-1", "protein_name": "Gametotin", "gene_name": "GGN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASGRSSDSRRTSLMEPEVTPSSPAMRLARGLGVWFPGSSPPPGLLVPPEPQASPSPLPLTLELPSPVTPPSEEAAAATVSTPPPPPVGTLLPAPSKWRKPTGTSVPRIRGLLEASHRGQGDPPSLRPLPPPPRQLTEEDSNPVPRALSPIPPPSELRKPPLPPPSDRQPLDRKITPALATPAATPTESQARRGSEVQTACGARRGAPPQAGEGEMALPAASEPGLNLLCKVTFKSGPPLPPAAASSSLAAKASLGGGGGGAGLFSATSGAISYAEVLKQGPAPGTARSPGEVPRGTQEAEGGDGDSEGCSGPPSAPVSHVRTLPPPPYTTFPGSKPKFDWVSPPDGPERHFRFNGAGGGVGAPRRRAATLSGPWGSPPPPPGQMHPAPGPRRPAPALLAPPMFIFPAPANGEPVCPGPPDPQEVLPPPLPPPTPPPTPPPAPPPTPQPPMPQPTPLPAALPPTAGPGHLESAVAPAPPPALPLALATEQAQAPAPTPASAQAPAPAPAPITAEPSPPVPAPAKARTRRNKGPRAVRAAPREDGPPGDGLRERTAATVTDSGGGGGGSSRAPPAGTAPSGAARHWPPFQVLNSCPCKCYCRHQPRHRRLPRNVSAW", "length": 633 }, "evidence": [ { "id": "A0AAA9SRA6", "url": "https://omabrowser.org/oma/group/A0AAA9SRA6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q66HC8-1", "protein_name": "Gametogenetin", "gene_name": "Ggn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASDRASDSRRTPLVEPEVTPSSPAMRLARGLGVWFPGSSGPPGLLIPPESQASSSTLPLTLELPSPVTPPPEEAAAAAVSTPPPPPVGTLLPAPSKWRKPTGTAVPRIRGLLEASHRGQGDPPSLRPLPPLPRQLTEKDPVLRAPAPPPTPLEPRKQLPPAPSTCDPQPPSRRITLASSATSPTESQVRHSSEGQAAGGAHGEGEMARSATSESGLSLLCKVTFKSGPHLSPTSSSGPLAAKASLGASGGGGLFASSGAISYAEVLKQGPQPPGATRPLGEGPRAAQETEGGDGDGEGCSGPPSVPTPLARALPPPPYTTFPGSKPKFDWVSPPDGTERHFRFNGAVGGIGAPRRRTTTLSGPWGSPPPRSGQTHPSSGPRRPTPALLAPPMFIFPAPNNGEPVRPVPPSPQQIPPLPPPPPTPPATPPPAPPPTPQPPALPRTPILVARPPTPGPGHLESALAPTPPSTLSPTAAAEQAPAPTPAPVTSQVPATTTAELSPPMPQPKIRTRRNKGPRAARGVIREEGTSGDGPREPNMAPVTDSSSGGGGGGSNGTSTAGASNKGTARHWPPFEVLNSCPCKCYCRHQRRHRRLPRNVSAWLSTPTNHLSEPPWVATVKLAGSLVAGLEHYDLQATHST", "length": 658 }, "evidence": [ { "id": "A0AAA9SRA6", "url": "https://omabrowser.org/oma/group/A0AAA9SRA6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80WJ1-1", "protein_name": "Gametogenetin", "gene_name": "Ggn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNVQSEPSAGGGSRKEQASDRASDSRRTPLVEPEVTPSSPAMRLARGLGVWFPGSSGPPGLLIPPEPQASSSPLPLTLELPSPVTPPPEEAAAVSTPPPPPVGTLLPAPSKWRKPTGTSVPRIRGLLEASHRGQGDPPSLRPLPPLPRQLTEKDPVLRAPAPPPTPLEPRKQLPPAPSTCDPQPLSRRITLASSATSPTESQVRHSSEGQAAGGAHGGVPPQAGEGEMARSATSESGLSLLCKVTFKSGPHLSPTSASGPLAAKASPGAGGGGLFASSGAISYAEVLKQGPQPPGATRPLGEVPPGATRPLGEVPRAAQETEGGDGDGEGCSGPPSVPAPLARALPPPPYTTFPGSKPKFDWVSPPDGTERHFRFNGAVGGIGAPRRRTTTLSGPWGSPPPRSGQTHPSSGPRRPTPALLAPPMFIFPAPNNGEPVRPVPPSPQQIPPLPPPPPTPPATPPPAPPPTPQPPALPRTPILVARPPTPGPGHLESALAPTPPSTLSPTAAADQVPAATPATVTSQVPATATAELSPPMPQPKTRTRRNKGPRAARGVIREEGTSGDGPREPNTAPVTDSSSGGGGGGSNGTSTAGASNKGTARHWPPFEVLNSCPCKCYCRHQRRHRRLPRNVSAWLSTPTNHLSEPPWVATVKLAGSLVAGLEHYDLQATHST", "length": 673 }, "evidence": [ { "id": "A0AAA9SRA6", "url": "https://omabrowser.org/oma/group/A0AAA9SRA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86UU5-1", "protein_name": "Gametogenetin", "gene_name": "GGN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNLQSEPSAGGGSRKVQPSDRAPDSRRTSLVEPEMTSQAMRLTRGLGVWFPGSATPPGLMVPREPQASPSTLPLTLERPSPVMPPPEEAAAVSAPPPAPAGTLLPGPSKWQKPAGTPVPRIRRLLEASHRGQGDPPSLRPLKPPPPPRQLSVKDTVPRAPSQFPPPLETWKPPPPLPSERQPADRRITPALATPASPPTESQAGPRNQGQTAGRARGGAPPHAGEGEMAQPADSESGLSLLCKITFKSRPSLAPPAASSSLAAKASLGGGGGGGLFAASGAISYAEVLKQGPLPPGAARPLGEVSRGAQEAEGGDGDGEGCSGPPSAPASQARALPPPPYTTFPGSKPKFDWVSAPDGPERHFRFNGAGGGIGAPRRRAAALSGPWGSPPPPPEQIHSAPGPRRPAPALLAPPTFIFPAPTNGEPMRPGPPGLQELPPLPPPTPPPTLQPPALQPTPLPVAPPLTPGLGHKESALAPTAAPALPPALAADQAPAPSPAPAPTVAEPSPPVSAPAPAAAPIKTRTRRNKGSRAARGATRKDGLHGDGPRERATATVPDSSGGGGGGSGASQTGAANTRAARHWLPFQVLNSCPCKCYCHHQPRHRRLPRNVSAWLSTSTNHLGEPPWVATIKLSGSLVAKLEHYDLQATHSN", "length": 652 }, "evidence": [ { "id": "A0AAA9SRA6", "url": "https://omabrowser.org/oma/group/A0AAA9SRA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6" } ], "pmid": "" }, { "name": "gamete generation", "id": "GO:0007276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 629, "end_pos": 631, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 37, 86, 168, 198, 449, 453, 461, 490, 528 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 629, "end_pos": 631 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 9 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 9 }, { "field": "exact_o_linked_sites", "count": 9 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 9 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 9 }, { "field": "exact_o_linked_sites", "count": 9 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR44-1", "uniprot_ac": "A0AAA9SR44", "uniprot_id": "A0AAA9SR44_BOVIN", "mass": { "chemical_mass": 159222.0, "monoisotopic_mass": 159222.0 }, "refseq": {}, "gene_names": [ { "name": "LRPPRC", "type": "recommended", "evidence": [ { "id": "A0AAA9SR44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ] } ], "protein_names": [ { "name": "Leucine-rich PPR motif-containing protein, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9SR44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#names_and_taxonomy" } ] }, { "name": "130 kDa leucine-rich protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SR44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRPPRC", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44", "locus": { "chromosome": "11", "start_pos": 26107095, "end_pos": 26207593, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016368", "url": "https://www.ensembl.org/id/ENSBTAG00000016368" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016368", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPX9", "url": "https://www.orthodb.org/?gene=E1BPX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46669", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46669", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46669:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46669:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13812", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13812", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17177", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17177", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RVC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7U0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2X2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPX9", "url": "https://www.uniprot.org/uniprotkb/E1BPX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPX9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTVECFLLFFSTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKTSKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQRCGAIAEQIPILLVFCIRNSQRSGKAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1404, "header": "tr|A0AAA9SR44-1|A0AAA9SR44_BOVIN Isoform 1 of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9RVC5-1", "sequence": { "sequence": "INQAILIGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKTSKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQRCGAIAEQIPILLVFCIRNSQRSGKAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1351, "header": "tr|A0AAA9RVC5-1|A0AAA9SR44_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207593, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076246.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076246.1" } ] } }, { "isoform_ac": "A0AAA9S7D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9S7D4-1", "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQRCGAIAEQIPILLVFCIRNSQRSGKAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1355, "header": "tr|A0AAA9S7D4-1|A0AAA9SR44_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207379, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093434.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093434.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079820.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079820.1" } ] } }, { "isoform_ac": "A0AAA9S7U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9S7U0-1", "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKTSKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYNAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1286, "header": "tr|A0AAA9S7U0-1|A0AAA9SR44_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207379, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122232.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122232.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082095.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082095.1" } ] } }, { "isoform_ac": "A0AAA9SPW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9SPW4-1", "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFNFSY", "length": 532, "header": "tr|A0AAA9SPW4-1|A0AAA9SPW4_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207379, "end_pos": 26176526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118474.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118474.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088339.1" } ] } }, { "isoform_ac": "A0AAA9SR44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9SR44-1", "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTVECFLLFFSTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKTSKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQRCGAIAEQIPILLVFCIRNSQRSGKAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1404, "header": "tr|A0AAA9SR44-1|A0AAA9SR44_BOVIN Isoform 1 of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207379, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102974.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102974.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086526.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086526.1" } ] } }, { "isoform_ac": "A0AAA9T2X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9T2X2-1", "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKTSKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1369, "header": "tr|A0AAA9T2X2-1|A0AAA9T2X2_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207379, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117820.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117820.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093138.1" } ] } }, { "isoform_ac": "A0AAA9TWB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#A0AAA9TWB0-1", "sequence": { "sequence": "MAALLRSARWLLRATAAPYLPLSLRLLAGGPGRPHAALCLRAARARPVAGGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKTSKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQRCGAIAEQIPILLVFCIRNSQRSGKAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1379, "header": "tr|A0AAA9TWB0-1|A0AAA9TWB0_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=1 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26207379, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088402.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088402.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101732.1" } ] } }, { "isoform_ac": "E1BPX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44/entry#E1BPX9-1", "sequence": { "sequence": "MSGHVLGTPWELGVQRGLLSQARLHSIAAEKKNDLQEEPTSSHRRNASQFDWALMRLDNSVRRTGRIPKTLLQKVFDNTCHSGSPGGNQALLLLRSCGSLLPELKLSERTEFAHKIWDELQKLGTVYDVSHYNALLKVYLQNEHKFSPTDFLAKMEKGNVQPNRVTYQRLIAAYCNMGDIEGASTILGFMKTKDLPVTEAVFSALVTGHARSGDMENAENILTVMKEAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSDLYLMDRDLLQIILSFSKAGYPQYVPEILEKITYERRYIPDTMNLILLLVTEKLEDTALQILLACPISRESSLNDFGSFFLRHCVTVNTPPEQLRDYCKKLKEAQLHTSPLQFTLQCALVAQKFDLAKVLMKALKEEGFPIRTHYFWPLLVGHQKEKNVQGIVEVLKGMHEMGVTPDQETYVNYVFPSFDSIESVRAVLQENGCPHDDNVFSQAELRSKAVNGNLDYILSFMESNTLPFSFASLRGSLILGFRRSMNINLWSKITELLYKDGRYCQEPPGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLKEMNVKIPENIYRGIRNLLDSYHVPELIKDVNILVEREKTDSRKPSSSDLESKLEKLKAENQPIGDILKQLILMLCSEENMQKALELKAKYESDMVVGGYAALINLCCRHDNAEDALNLKREFDRLDSSAVLDTGKYVRLVKVLGKHGKLQDAINILKEMKEKDVLIKDATVLSFFHILNGAALRGETETVKQLHEAIVTLGLAKPSTTLSSPLVTLYLEKDDLPAALESTIDCYEKYKILPRIHDVLCKLIEKGETELIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTQKLFECDRDQLYYSLLKLYKVNGDWQKADAVWNKMQEENIIPREKTLRLLAEILRNNNQDVPFDVPELWYEEEKDSPTSLPSPVEVNLQKELLNACRTRRNKDAFNIFLTAKKQNIVFDNEAYARLINLLLMKDNSTQAMQVKDFAETHIKGFTLNDAANSLLIITQVRRDYLKDALTTLKTALDLDQIPSRLAVTRLIQACALKGDTESVQDIQKLVNGLEDSIGLSRMVFINNIALAQIKNNNIDVAIESIENMLTSENQTVDPQYFGLAYLFRKVIEGQLEPALEKISIMVERLANQFAVYKPVTDLFLQLVDSGKVDDARALLQRCGAIAEQIPILLVFCIRNSQRSGKAPVMKSLLELIPELIDKEEAYSCLMKSYVFDSDVASAKALYESLTAKNVKLNDLFLKRYAVLLKNAGESVPFTEPPESFEFYAKQLKESKETHL", "length": 1357, "header": "tr|E1BPX9-1|A0AAA9SR44_BOVIN Computationally mapped isoform of Leucine-rich PPR motif-containing protein, mitochondrial OS=Bos taurus OX=9913 GN=LRPPRC PE=4 SV=4 CANONICAL=A0AAA9SR44-1" }, "locus": { "chromosome": "11", "start_pos": 26206632, "end_pos": 26108099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021773.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021773.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021773.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021773.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 579, "start_aa": "Thr", "end_pos": 579, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr579", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "beta-tubulin binding", "id": "GO:0048487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048487", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "mitochondrial mRNA polyadenylation", "id": "GO:0097222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "negative regulation of mitochondrial mRNA catabolic process", "id": "GO:1905638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905638", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" }, { "name": "regulation of mitochondrial translation", "id": "GO:0070129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070129", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1092, "end_pos": 1094, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1218, "end_pos": 1220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SR44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR44" }, { "id": "PF17177", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17177" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PROP1-like PPR", "eco_id": "ECO_0000259", "start_pos": 224, "end_pos": 331, "start_aa": "Met", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 579 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1092, "end_pos": 1094 }, { "start_pos": 1218, "end_pos": 1220 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPR0-1", "uniprot_ac": "A0AAA9SPR0", "uniprot_id": "A0AAA9SPR0_BOVIN", "mass": { "chemical_mass": 50409.0, "monoisotopic_mass": 50409.0 }, "refseq": { "ac": "XP_024833660", "name": "reticulon-4 receptor isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833660" }, "gene_names": [ { "name": "RTN4R", "type": "recommended", "evidence": [ { "id": "A0AAA9SPR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ] }, { "name": "RTN4R", "type": "synonym", "evidence": [ { "id": "XP_024833660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833660" } ] } ], "protein_names": [ { "name": "Reticulon 4 receptor", "type": "synonym", "evidence": [ { "id": "A0AAA9SPR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0/entry#names_and_taxonomy" } ] }, { "name": "reticulon-4 receptor isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024833660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833660" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTN4R", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0", "locus": { "chromosome": "17", "start_pos": 73065905, "end_pos": 73085401, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046677", "url": "https://www.ensembl.org/id/ENSBTAG00000046677" } ] } } ], "crossref": [ { "id": "A0AAA9SPR0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPR0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046677", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046677", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100299284", "url": "https://www.ncbi.nlm.nih.gov/gene/100299284", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100299284", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299284", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RSQCRMA", "url": "https://omabrowser.org/oma/group/RSQCRMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3MXX5", "url": "https://www.orthodb.org/?gene=G3MXX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF174", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF174", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833660", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833660", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RVL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXX5", "url": "https://www.uniprot.org/uniprotkb/G3MXX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXX5-1", "url": "https://www.uniprot.org/uniprotkb/G3MXX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRASARGSQLLAWVLWLQAWRVAAPCPGACVCYSEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRIAYVPAASFRACRNLTILWLHSNALAHIDAAAFSGLALLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNGLQALPDDAFSDLGNLTHLFLHGNHIPSVPERAFRGLHSLDRLLLHQNRVARVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRSLQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPARLAGRDLKRLAATDLEGCAVATLPAPPIWTGGPVHEEPLGLPKCCQPDAVDKASVLEAGRPASAGNALKGRVPPGDSAPGNRSGPRHINDSPFGTLPGSAEPPLTAVQPEGSQPPGSPTTGPRRRPGCSRKNRTRSQCRLGQAGSGGGGSGAVEGSGTPSGLACSLVPLALAPVLWTVLGRC", "length": 473, "header": "tr|A0AAA9SPR0-1|A0AAA9SPR0_BOVIN Isoform 1 of Reticulon 4 receptor OS=Bos taurus OX=9913 GN=RTN4R PE=3 SV=1 CANONICAL=A0AAA9SPR0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0/entry#A0AAA9RVL6-1", "sequence": { "sequence": "MAGGARIPALEVSGRSPSCKPRPRWPHPPQGRSPSCKPRPNKAPPTHRDNSPFRTAPPSPAPPTHRGGIPPANAGPDPPTSPLPAGSQLLAWVLWLQAWRVAAPCPGACVCYSEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRIAYVPAASFRACRNLTILWLHSNALAHIDAAAFSGLALLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNGLQALPDDAFSDLGNLTHLFLHGNHIPSVPERAFRGLHSLDRLLLHQNRVARVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRSLQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPARLAGRDLKRLAATDLEGCAVATLPAPPIWTGGPVHEEPLGLPKCCQPDAVDKASVLEAGRPASAGNALKGRVPPGDSAPGNRSGPRHINDSPFGTLPGSAEPPLTAVQPEGSQPPGSPTTGPRRRPGCSRKNRTRSQCRLGQAGSGGGGSGAVEGSGTPSGLACSLVPLALAPVLWTVLGRC", "length": 551, "header": "tr|A0AAA9RVL6-1|A0AAA9SPR0_BOVIN Computationally mapped isoform of Reticulon 4 receptor OS=Bos taurus OX=9913 GN=RTN4R PE=3 SV=1 CANONICAL=A0AAA9SPR0-1" }, "locus": { "chromosome": "17", "start_pos": 73068404, "end_pos": 73066752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116745.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116745.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075015.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075015.1" } ] } }, { "isoform_ac": "A0AAA9SAA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0/entry#A0AAA9SAA3-1", "sequence": { "sequence": "SQLLAWVLWLQAWRVAAPCPGACVCYSEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRIAYVPAASFRACRNLTILWLHSNALAHIDAAAFSGLALLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNGLQALPDDAFSDLGNLTHLFLHGNHIPSVPERAFRGLHSLDRLLLHQNRVARVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRSLQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPARLAGRDLKRLAATDLEGCAVATLPAPPIWTGGPVHEEPLGLPKCCQPDAVDKASVLEAGRPASAGNALKGRVPPGDSAPGNRSGPRHINDSPFGTLPGSAEPPLTAVQPEGSQPPGSPTTGPRRRPGCSRKNRTRSQCRLGQAGSGG", "length": 430, "header": "tr|A0AAA9SAA3-1|A0AAA9SPR0_BOVIN Computationally mapped isoform of Reticulon 4 receptor OS=Bos taurus OX=9913 GN=RTN4R PE=3 SV=1 CANONICAL=A0AAA9SPR0-1" }, "locus": { "chromosome": "17", "start_pos": 73068146, "end_pos": 73066857, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082262.1" } ] } }, { "isoform_ac": "A0AAA9SG55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0/entry#A0AAA9SG55-1", "sequence": { "sequence": "MLPARLLLSRTLLCPPPLNEACTGGLVRKSLFCSGSQIPASGTHTPASPPSTSPSSARGWRRGAGWGSQLLAWVLWLQAWRVAAPCPGACVCYSEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRIAYVPAASFRACRNLTILWLHSNALAHIDAAAFSGLALLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNGLQALPDDAFSDLGNLTHLFLHGNHIPSVPERAFRGLHSLDRLLLHQNRVARVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRSLQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPARLAGRDLKRLAATDLEGCAVATLPAPPIWTGGPVHEEPLGLPKCCQPDAVDKASVLEAGRPASAGNALKGRVPPGDSAPGNRSGPRHINDSPFGTLPGSAEPPLTAVQPEGSQPPGSPTTGPRRRPGCSRKNRTRSQCRLGQAGSGGGGSGAVEGSGTPSGLACSLVPLALAPVLWTVLGRC", "length": 532, "header": "tr|A0AAA9SG55-1|A0AAA9SPR0_BOVIN Computationally mapped isoform of Reticulon 4 receptor OS=Bos taurus OX=9913 GN=RTN4R PE=3 SV=1 CANONICAL=A0AAA9SPR0-1" }, "locus": { "chromosome": "17", "start_pos": 73079938, "end_pos": 73066752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129835.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129835.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085147.1" } ] } }, { "isoform_ac": "A0AAA9SPR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0/entry#A0AAA9SPR0-1", "sequence": { "sequence": "MKRASARGSQLLAWVLWLQAWRVAAPCPGACVCYSEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRIAYVPAASFRACRNLTILWLHSNALAHIDAAAFSGLALLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNGLQALPDDAFSDLGNLTHLFLHGNHIPSVPERAFRGLHSLDRLLLHQNRVARVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRSLQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPARLAGRDLKRLAATDLEGCAVATLPAPPIWTGGPVHEEPLGLPKCCQPDAVDKASVLEAGRPASAGNALKGRVPPGDSAPGNRSGPRHINDSPFGTLPGSAEPPLTAVQPEGSQPPGSPTTGPRRRPGCSRKNRTRSQCRLGQAGSGGGGSGAVEGSGTPSGLACSLVPLALAPVLWTVLGRC", "length": 473, "header": "tr|A0AAA9SPR0-1|A0AAA9SPR0_BOVIN Isoform 1 of Reticulon 4 receptor OS=Bos taurus OX=9913 GN=RTN4R PE=3 SV=1 CANONICAL=A0AAA9SPR0-1" }, "locus": { "chromosome": "17", "start_pos": 73085122, "end_pos": 73066752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087352.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087352.1" } ] } }, { "isoform_ac": "G3MXX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0/entry#G3MXX5-1", "sequence": { "sequence": "THSRGRKNLCIQRRGSNSGVTGREPSAGHVTLPVSPAWGKHPGALSHPLQVLGSQLLAWVLWLQAWRVAAPCPGACVCYSEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRIAYVPAASFRACRNLTILWLHSNALAHIDAAAFSGLALLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNGLQALPDDAFSDLGNLTHLFLHGNHIPSVPERAFRGLHSLDRLLLHQNRVARVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRSLQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPARLAGRDLKRLAATDLEGCAVATLPAPPIWTGGPVHEEPLGLPKCCQPDAVDKASVLEAGRPASAGNALKGRVPPGDSAPGNRSGPRHINDSPFGTLPGSAEPPLTAVQPEGSQPPGSPTTGPRRRPGCSRKNRTRSQCRLGQAGSGGGGSGAVEGSGTPSGLACSLVPLALAPVLWTVLGRC", "length": 518, "header": "tr|G3MXX5-1|G3MXX5_BOVIN Computationally mapped isoform of Reticulon 4 receptor OS=Bos taurus OX=9913 GN=RTN4R PE=3 SV=3 CANONICAL=A0AAA9SPR0-1" }, "locus": { "chromosome": "17", "start_pos": 73069349, "end_pos": 73066752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065527.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065527.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054397.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054397.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100299284", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299284", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZLA8-1", "protein_name": "Reticulon 4 receptor", "gene_name": "RTN4R", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKRASAGGSQLLAWVLWLQAWRVAAPCPGACVCYNEPKVTTSCPQQGLQAVPADIPAASQRVFLHGNRITYVPAASFRACRNLTILWLHSNALARIDATAFAGLVLLEQLDLSDNAQLRAVDPATFRGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNGLQALPDDAFRDLGNLTHLFLHGNRIPSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALSAEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQQFRGSSSELPCSLPPRLAGRDLKRLATTDLEGCFVAAGPSRPFRTGGPADEELLGLPKCCQPDAADKASVLEAGSPASAGNALKGRVPSGDSPPGNRSGPRHINDSPFGTLPGSAEPPLTVVQPEGAEPPGPPTTGPRRRPGCSRKNRTRSQCRLGQAGSGGSGAGEVEGSGALPSLTCSLVPLGLVLVLWTVLGPC", "length": 473 }, "evidence": [ { "id": "A0AAA9SPR0", "url": "https://omabrowser.org/oma/group/A0AAA9SPR0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0X765-1", "protein_name": "Reticulon 4 receptor", "gene_name": "RTN4R", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRAIAEGSSDSTVISLGEIITVDRILSRKPQGSKLLILVLCLNIQSEVESCPGACVCYSEPKITISCQQQGLTAIPTEIPIQSQRIFLHNNKITLVRSTSFTSCRNMTILWIHSNNISLIEPGAFYGLNKLEELDLSDNTNLKSINPVTFRGLVHLHTLHLDRCGLMELSTGLFRGLFSLQYLYLQDNNLQNLLDDTFIDLANLTYLFLHGNKIKSLSENVFRGLINLDRLLLHQNRVSLVHRRSFHDLGKVMTLYLFNNNLTVLTGETMAPLVSLQYLRLNGNQWICDCQARSLWNWFKQFKGSSSELECHLPPHLAGRDLKRLQSSDLEGCIDSFNQIRTSVFSTKTRSGKLATGSPPLSSHDGSMKCCQPEMDKSFIYEAKGKAGPSSHSSRPSSNNPLKDKENMSKTKYVETDPSKNGSNKQINDSPFGTFPSIVDPPLTKLRPEFLEPIEPSTVPTKKRQGCSKKNKSKAQCRLTQQGNSSTLQLSLSLLIPPLVWSLLLLC", "length": 508 }, "evidence": [ { "id": "A0AAA9SPR0", "url": "https://omabrowser.org/oma/group/A0AAA9SPR0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q99M75-1", "protein_name": "Reticulon-4 receptor", "gene_name": "Rtn4r", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKRASSGGSRLLAWVLWLQAWRVATPCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISYVPAASFQSCRNLTILWLHSNALAGIDAAAFTGLTLLEQLDLSDNAQLRVVDPTTFRGLGHLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLVPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCNLPQRLAGRDLKRLAASDLEGCAVASGPFRPFQTNQLTDEELLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPGSAEPPLTALRPGGSEPPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGSSGTGDAEGSGALPALACSLAPLGLALVLWTVLGPC", "length": 473 }, "evidence": [ { "id": "A0AAA9SPR0", "url": "https://omabrowser.org/oma/group/A0AAA9SPR0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99PI8-1", "protein_name": "Reticulon-4 receptor", "gene_name": "Rtn4r", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRASSGGSRLLAWVLWLQAWRVATPCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISHVPAASFQSCRNLTILWLHSNALARIDAAAFTGLTLLEQLDLSDNAQLHVVDPTTFHGLGHLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLMPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCNLPQRLADRDLKRLAASDLEGCAVASGPFRPIQTSQLTDEELLSLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPSSAEPPLTALRPGGSEPPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGASGTGDAEGSGALPALACSLAPLGLALVLWTVLGPC", "length": 473 }, "evidence": [ { "id": "A0AAA9SPR0", "url": "https://omabrowser.org/oma/group/A0AAA9SPR0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZR6-1", "protein_name": "Reticulon-4 receptor", "gene_name": "RTN4R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC", "length": 473 }, "evidence": [ { "id": "A0AAA9SPR0", "url": "https://omabrowser.org/oma/group/A0AAA9SPR0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "neuregulin receptor activity", "id": "GO:0038131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038131", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "ganglioside GM1 binding", "id": "GO:1905573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905573", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "chondroitin sulfate binding", "id": "GO:0035374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "ganglioside GT1b binding", "id": "GO:1905576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "Roundabout binding", "id": "GO:0048495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048495", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "dendritic shaft", "id": "GO:0043198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "axonal growth cone", "id": "GO:0044295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044295", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "neuronal signal transduction", "id": "GO:0023041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "positive regulation of Rho protein signal transduction", "id": "GO:0035025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "corpus callosum development", "id": "GO:0022038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "negative regulation of axon extension", "id": "GO:0030517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "negative regulation of axon regeneration", "id": "GO:0048681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048681", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPR0" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 260, "end_pos": 310, "start_aa": "Asn", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 }, { "start_pos": 237, "end_pos": 239 }, { "start_pos": 372, "end_pos": 374 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMT7-1", "uniprot_ac": "A0AAA9SMT7", "uniprot_id": "A0AAA9SMT7_BOVIN", "mass": { "chemical_mass": 50227.0, "monoisotopic_mass": 50227.0 }, "refseq": { "ac": "XP_024842157", "name": "retinoic acid receptor beta isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842157" }, "gene_names": [ { "name": "RARB", "type": "recommended", "evidence": [ { "id": "A0AAA9SMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ] }, { "name": "RARB", "type": "synonym", "evidence": [ { "id": "XP_024842157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842157" } ] } ], "protein_names": [ { "name": "Retinoic acid receptor beta", "type": "recommended", "evidence": [ { "id": "A0AAA9SMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor subfamily 1 group B member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#names_and_taxonomy" } ] }, { "name": "retinoic acid receptor beta isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024842157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842157" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RARB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7", "locus": { "chromosome": "27", "start_pos": 40196882, "end_pos": 40645068, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011518", "url": "https://www.ensembl.org/id/ENSBTAG00000011518" } ] } } ], "crossref": [ { "id": "A0AAA9SMT7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMT7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011518", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011518", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06937", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06937", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06964", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06964", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616895", "url": "https://www.ncbi.nlm.nih.gov/gene/616895", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616895", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616895", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TDWQHRH", "url": "https://omabrowser.org/oma/group/TDWQHRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3X6X1", "url": "https://www.orthodb.org/?gene=G3X6X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24085", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24085", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24085:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24085:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5362517", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5362517", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024842157", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842157", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RVN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0K3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0K3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNF4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNF4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6X1", "url": "https://www.uniprot.org/uniprotkb/G3X6X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6X1-1", "url": "https://www.uniprot.org/uniprotkb/G3X6X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFDCMDVLSVSPGRILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFAGQLLPLEMDDAETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSGGHTAEPSPSVSPSSVEHSGVGQSPLLQ", "length": 448, "header": "tr|A0AAA9SMT7-1|A0AAA9SMT7_BOVIN Isoform 1 of Retinoic acid receptor beta OS=Bos taurus OX=9913 GN=RARB PE=3 SV=1 CANONICAL=A0AAA9SMT7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#A0AAA9RVN4-1", "sequence": { "sequence": "TPLVLSLLWAGPRGAQHPPRQSTELPAWRFPDGWSGAQLGCCCWRGSHLEPKLNRTIAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKECPVPVPQIFSSFSLLGGSGLVAQSCPTLATAWTTAHQAPLSLGFISCSSELFRSSGHGVLR", "length": 215, "header": "tr|A0AAA9RVN4-1|A0AAA9SMT7_BOVIN Computationally mapped isoform of Retinoic acid receptor beta OS=Bos taurus OX=9913 GN=RARB PE=3 SV=2 CANONICAL=A0AAA9SMT7-1" }, "locus": { "chromosome": "27", "start_pos": 40354072, "end_pos": 40285596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125251.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125251.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076401.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076401.2" } ] } }, { "isoform_ac": "A0AAA9SMT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#A0AAA9SMT7-1", "sequence": { "sequence": "MFDCMDVLSVSPGRILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFAGQLLPLEMDDAETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSGGHTAEPSPSVSPSSVEHSGVGQSPLLQ", "length": 448, "header": "tr|A0AAA9SMT7-1|A0AAA9SMT7_BOVIN Isoform 1 of Retinoic acid receptor beta OS=Bos taurus OX=9913 GN=RARB PE=3 SV=1 CANONICAL=A0AAA9SMT7-1" }, "locus": { "chromosome": "27", "start_pos": 40381619, "end_pos": 40197886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090453.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090453.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086624.1" } ] } }, { "isoform_ac": "A0AAA9T0K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#A0AAA9T0K3-1", "sequence": { "sequence": "MTTRSPACHVPAVSGHMAHYPAAPYPLLFPPVIGGLPLPPLHGLHGPPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFAGQLLPLEMDDAETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSGGHTAEPSPSVSPSSVEHSGVGQSPLLQ", "length": 455, "header": "tr|A0AAA9T0K3-1|A0AAA9T0K3_BOVIN Computationally mapped isoform of Retinoic acid receptor beta OS=Bos taurus OX=9913 GN=RARB PE=3 SV=1 CANONICAL=A0AAA9SMT7-1" }, "locus": { "chromosome": "27", "start_pos": 40644869, "end_pos": 40197886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131392.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131392.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091230.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091230.1" } ] } }, { "isoform_ac": "A0ABI0NNF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#A0ABI0NNF4-1", "sequence": { "sequence": "TPLVLSLLWAGPRGAQHPPRQSTELPAWRFPDGWSGAQLGCCCWRGSHLEPKLNRTIAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKEFSTHASMAPAILGERRCPHRPGGPDPGAIYVFLSPQPRPRPHWDLLC", "length": 201, "header": "tr|A0ABI0NNF4-1|A0ABI0NNF4_BOVIN Computationally mapped isoform of Retinoic acid receptor beta OS=Bos taurus OX=9913 GN=RARB PE=3 SV=1 CANONICAL=A0AAA9SMT7-1" }, "locus": { "chromosome": "27", "start_pos": 40354072, "end_pos": 40234518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145484.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145484.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107316.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107316.1" } ] } }, { "isoform_ac": "G3X6X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7/entry#G3X6X1-1", "sequence": { "sequence": "MFDCMDVLSVSPGRILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILVQSV", "length": 266, "header": "tr|G3X6X1-1|G3X6X1_BOVIN Computationally mapped isoform of Retinoic acid receptor beta OS=Bos taurus OX=9913 GN=RARB PE=3 SV=3 CANONICAL=A0AAA9SMT7-1" }, "locus": { "chromosome": "27", "start_pos": 40381619, "end_pos": 40198068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015305.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015305.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015305.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015305.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616895", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616895", "resource": "KEGG Pathway" }, { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" }, { "id": "R-BTA-5362517", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5362517", "resource": "Reactome", "description": "Signaling by Retinoic Acid" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7HD75-1", "protein_name": "Retinoic acid receptor beta", "gene_name": "Rarb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSVSPSSVENSGVSQSPLLQ", "length": 455 }, "evidence": [ { "id": "A0AAA9SMT7", "url": "https://omabrowser.org/oma/group/A0AAA9SMT7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P10826-1", "protein_name": "Retinoic acid receptor beta", "gene_name": "RARB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ", "length": 455 }, "evidence": [ { "id": "A0AAA9SMT7", "url": "https://omabrowser.org/oma/group/A0AAA9SMT7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P22448-1", "protein_name": "Retinoic acid receptor beta", "gene_name": "RARB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTTSSRTCPVPAVNGHMTHYPAAPYPLLFPPVIGGLSLPSLHGLQSHPPTSGCSTPSPATVETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPTKQESTENYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTSLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPMKVDKLQEPLLEALKIYIRKRRPNKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPTSNGNTAEHSPSISPSSVDNSSVSQSPMVQ", "length": 455 }, "evidence": [ { "id": "A0AAA9SMT7", "url": "https://omabrowser.org/oma/group/A0AAA9SMT7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P22605-1", "protein_name": "Retinoic acid receptor beta", "gene_name": "Rarb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPASVGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ", "length": 482 }, "evidence": [ { "id": "A0AAA9SMT7", "url": "https://omabrowser.org/oma/group/A0AAA9SMT7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "retinoic acid receptor signaling pathway", "id": "GO:0048384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048384", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "embryonic digestive tract development", "id": "GO:0048566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048566", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 410, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT7" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 153, "start_aa": "Tyr", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 286, "end_pos": 288 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNB4-1", "uniprot_ac": "A0AAA9SNB4", "uniprot_id": "A0AAA9SNB4_BOVIN", "mass": { "chemical_mass": 71687.0, "monoisotopic_mass": 71687.0 }, "refseq": {}, "gene_names": [ { "name": "LOC507550", "type": "recommended", "evidence": [ { "id": "A0AAA9SNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4" } ] } ], "protein_names": [ { "name": "Stimulated by retinoic acid gene 6 protein-like", "type": "recommended", "evidence": [ { "id": "A0AAA9SNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC507550", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SNB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR026612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RFIYMLV", "url": "https://omabrowser.org/oma/group/RFIYMLV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21444", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21444", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21444:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21444:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RW77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPPNARTRQLNGTCDISVDMELFLHYSLIPSFFIILVLSFLQRREQQRERDDTYLLRNRFGMIVPLDFVGTFSNRWSYGVAFGATANKVMFLFSEGYQPLRVPQWAQAFVLLIGGIEVGLSHFPFFACLSSEFGLVSSVLGFSYSLVWFVVTTLYIIQCPHGQFVGNYETVMFYWPSLLCLAFLLGRFLHIFVKSLRVHLGWELQMEEKPFLEVHQAEHVKRLLRKCPLQERNKSWFQTRIYEWDPYFQFPSRMIGTIVLAFICLYLFIVIEFCVFVYVRDELDVFEGELESYITSMNQTGSPVLLQVKELINITKEVWVVTILPASLTCVSYLFHILACYRKHIKRLWAGDKHFLPLKFHNPSSSESVVAIARYSGWQIAYILWGYLIIHVMQSLCGLAIMYSLVLPVIHHQALEMLRGLGIGILTVSIVLGLMVLQVWIATSFFLQPKMGTDDKQKPLALNNRRAFHNFNYFLFFYNVLLGLGACLSRLFISCVLGTWLIARIDRTILQSGYERADMGFSAWIGMLYVDHYHTNPVLVSFCHILITSHRERRLQQTIKYWYLNQSAGPRLSARSRTRWLLLQTLINNPELVRLRKSRPGLGSQEFTQILLTCSES", "length": 618, "header": "tr|A0AAA9SNB4-1|A0AAA9SNB4_BOVIN Isoform 1 of Stimulated by retinoic acid gene 6 protein-like OS=Bos taurus OX=9913 GN=LOC507550 PE=4 SV=1 CANONICAL=A0AAA9SNB4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RW77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4/entry#A0AAA9RW77-1", "sequence": { "sequence": "MIYLLEVYKLRFGKCFLLFSHSVMSFAIPWTSAHQAPLSMGFLRQEYWRGLPFPSPEDLPNPETEPASPVLAGGFFTTQPPGKPMANVYIYEIITTIIMMNPGVNFFPFVLSSSHLYLVITPSLRQLYKWNHRFVVTTLYIIQCPHGQFVGNYETVMFYWPSLLCLAFLLGRFLHIFVKSLRVHLGWELQMEEKPFLEVHQAEHVKRLLRKCPLQERNKSWFQTRIYEWDPYFQFPSRMIGTIVLAFICLYLFIVIEFCVFVYVRDELDVFEGELESYITSMNQTGSPVLLQVKELINITKEVWVVTILPASLTCVSYLFHILACYRKHIKRLWAGDKHFLPLKFHNPSSSESVVAIARYSGWQIAYILWGYLIIHVMQSLCGLAIMYSLVLPVIHHQALEMLRGLGIGILTVSIVLGLMVLQVWIATSFFLQPKMGTDDKQKPLALNNRRAFHNFNYFLFFYNVLLGLGACLSRLFISCVLGTWLIARIDRTILQSGYERADMGFSAWIGMLYVDHYHTNPVLVSFCHILITSHRERRLQQTIKYWYLNQSAGPRLSARSRTRWLLLQTLINNPELVRLRKSRPGLGSQEFTQILLTCSES", "length": 602, "header": "tr|A0AAA9RW77-1|A0AAA9SNB4_BOVIN Computationally mapped isoform of Stimulated by retinoic acid gene 6 protein-like OS=Bos taurus OX=9913 GN=LOC507550 PE=4 SV=1 CANONICAL=A0AAA9SNB4-1" }, "locus": { "chromosome": "8", "start_pos": 62519594, "end_pos": 62495889, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119398.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119398.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075314.1" } ] } }, { "isoform_ac": "A0AAA9SNB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4/entry#A0AAA9SNB4-1", "sequence": { "sequence": "MFPPNARTRQLNGTCDISVDMELFLHYSLIPSFFIILVLSFLQRREQQRERDDTYLLRNRFGMIVPLDFVGTFSNRWSYGVAFGATANKVMFLFSEGYQPLRVPQWAQAFVLLIGGIEVGLSHFPFFACLSSEFGLVSSVLGFSYSLVWFVVTTLYIIQCPHGQFVGNYETVMFYWPSLLCLAFLLGRFLHIFVKSLRVHLGWELQMEEKPFLEVHQAEHVKRLLRKCPLQERNKSWFQTRIYEWDPYFQFPSRMIGTIVLAFICLYLFIVIEFCVFVYVRDELDVFEGELESYITSMNQTGSPVLLQVKELINITKEVWVVTILPASLTCVSYLFHILACYRKHIKRLWAGDKHFLPLKFHNPSSSESVVAIARYSGWQIAYILWGYLIIHVMQSLCGLAIMYSLVLPVIHHQALEMLRGLGIGILTVSIVLGLMVLQVWIATSFFLQPKMGTDDKQKPLALNNRRAFHNFNYFLFFYNVLLGLGACLSRLFISCVLGTWLIARIDRTILQSGYERADMGFSAWIGMLYVDHYHTNPVLVSFCHILITSHRERRLQQTIKYWYLNQSAGPRLSARSRTRWLLLQTLINNPELVRLRKSRPGLGSQEFTQILLTCSES", "length": 618, "header": "tr|A0AAA9SNB4-1|A0AAA9SNB4_BOVIN Isoform 1 of Stimulated by retinoic acid gene 6 protein-like OS=Bos taurus OX=9913 GN=LOC507550 PE=4 SV=1 CANONICAL=A0AAA9SNB4-1" }, "locus": { "chromosome": "8", "start_pos": 62519594, "end_pos": 62476527, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088171.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088171.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087803.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZZG1-1", "protein_name": "Stimulated by retinoic acid gene 6 protein-like", "gene_name": "LOC102168060", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLFPTARTRQLNGTCASSVNMELFLHYSLIPSLVIILVLSFLQRREHHRQRDDTSYLLGNHFGLIIPLDFVGTFSNRWSYGVAFGATANKVMFLFSEGYQPLQVPQWAQAFVLLIGGIEVGLCHFPFFACLSSEFRLVSSILGFSYSLIWFAVTMLYIIECPHGEFVGRYETIMFYWPSLLCLAFLLGRFLHMFVKSLRVHLGWELQIEEKPFLEVHQAEHVKQLLRKCPLQEREKSWFQTRIYEWDSCFQFPSRMIGTTVLAFICLYLFIVIEFCVFVYVRDELDVFERELEDYISSMNQTGTLTPVLLQVKELINVTKGVWLVTILPASLTCVSYLFHILACYRKHMKRLWAGDKQFLPLKFHSPSSSESVVAIARYSGWQIAYILWGYLIIHVMQSLCGVVIMYSLVLPVIHNQAMAMLRGLGIGTLTISIVLGLMVMQVWIAASFFLQPKMGPADKQKPLALNNRRAFHNFSYFLFFYNVLLGLGACLSRLLISCILGTWLIARIDRTILQSGYEGADLGFSAWIGMLYVDHYHANPVLVSFCHILITSHRERRQQQAIKYWYLNPSAGPRISVRSRTRWLLLQTLINNPGLIKLRKSRSGHSSQEFTQILLTCSES", "length": 621 }, "evidence": [ { "id": "A0AAA9SNB4", "url": "https://omabrowser.org/oma/group/A0AAA9SNB4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QN25-1", "protein_name": "Stimulated by retinoic acid gene 6 protein-like", "gene_name": "LOC100765804", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLAASTRTRQLNVTCDSSVDREFFLHYSLIPSLFIILVLSFLQRREHRRQRDDTFYLLGDHFGIIMPLDFVGTFSNRWSYGIAFGATANKVMFLFSEGYQPLKVPQWAQAFVLLIGGMEVGLSYFPFFACLSSEFRLVSSILGFSYSLTWFVVTILQISQCPHGQFLGRFETLIFYWPSLLCLGFLLCRFLYMFLKALPIHLGLEPQAEEKSVLEAHQAEHVKRLLRKSCPQEREKSWFQTRVYDWDPCFQFPSRMIGTLVLASICLYLFIVIEFCVFLLVKDKLDLFEDRLQSYLTHMNETGTSTPAILQVKELISVTKGVWVVTILPASLTCVSYLFHILACYRKHMKRLWAGDKDFLPQNFQSPSSAASVVAIARYSGWQIAYILWGYLIIHVVQSLCGVMLMYSLVLPILHHQGLEMLRGLGLGVLTLSIVVGLMILQVWIAGRFFLQPKLSTADKQKPLALHNRRAFHNFNYFLFFYNVLLGLGACLSRLLISCFLGTWLIARIDRTIMQSGYEGVDMGFNAWVGMLFVDHYHTNPVLVSFCHILITSHRDRKLQKITKYWYLNQSAGPRFSARAQTRWLLLQTLINNPRLITLRKSKSGHGFRELTQILPTCSDC", "length": 621 }, "evidence": [ { "id": "A0AAA9SNB4", "url": "https://omabrowser.org/oma/group/A0AAA9SNB4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9DBN1-1", "protein_name": "Stimulated by retinoic acid gene 6 protein-like", "gene_name": "Stra6l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLAASTRTRQINITCDNPVDREVFLHYSLIPSLCIILVLSFLQRREHRRQRDDTSYLLGNHFGIIVPLDFVGTFSNRWSYGAAFGATANKVMFLFSEGYQPLTVPQWAQAFVLFIGGMEVGLSYFPFFACLSSEFQLVSSILGFSYSLTWFVVTVLQISQCPHGQFLGRFETLVFYWPSLLCLGFLLGRFLHMFLKALPVHLGLEPQTEEKSMLEAHQAKHVKQLLSKPRPQEGEKSWFQTRVYEWDPCFQFPSRMVGTLLLAFICLYLFIVIEFCVFLHVRDKLDMFEDKLESYLTHMNETGTLTPIILQVKELISVTKGVWVVTILPAALTCVTYLFHILACYRKHMKRLWAGDKHFLPQKFHSPSSAASVVAIARYSGWQIAYILWGYLIIHVVQSLCGVMLMYGLVLPIIHHRGLEMLQGFGLGVLTLSIVVGLIILQVWIAGTFFLQPKLGTSDKQKPLALNNRRAFHNFNYFLFFYNVLLGLGACLSRLLISCLLGTWLIARIDRTIMQSGYEGADMGFGAWIGMLFVDHYHTNPVLVSFCHILITSHKDRKLQKTVKYWCLNQSAGPRFSARARTRWFLLQTLINNPRLVMLRKSKSGHSSGEFTQILLTCSDC", "length": 621 }, "evidence": [ { "id": "A0AAA9SNB4", "url": "https://omabrowser.org/oma/group/A0AAA9SNB4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "retinol transmembrane transporter activity", "id": "GO:0034632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034632", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 234, "end_pos": 236 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 314, "end_pos": 316 }, { "start_pos": 566, "end_pos": 568 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNZ6-1", "uniprot_ac": "A0AAA9SNZ6", "uniprot_id": "A0AAA9SNZ6_BOVIN", "mass": { "chemical_mass": 78658.0, "monoisotopic_mass": 78658.0 }, "refseq": {}, "gene_names": [ { "name": "PRSS53", "type": "recommended", "evidence": [ { "id": "A0AAA9SNZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6" } ] } ], "protein_names": [ { "name": "Serine protease 53", "type": "recommended", "evidence": [ { "id": "A0AAA9SNZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6/entry#names_and_taxonomy" } ] }, { "name": "Polyserine protease 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SNZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RXI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI3#function" }, { "database": "UniProtKB", "id": "ARBA00054080", "url": "https://www.uniprot.org/uniprotkb/ARBA00054080#function" } ] }, { "annotation": "In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG7#function" }, { "database": "UniProtKB", "id": "ARBA00057108", "url": "https://www.uniprot.org/uniprotkb/ARBA00057108#function" }, { "database": "UniProtKB", "id": "A0AAA9SNZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6#function" }, { "database": "UniProtKB", "id": "F1N116", "url": "https://www.uniprot.org/uniprotkb/F1N116#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRSS53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6", "locus": { "chromosome": "25", "start_pos": 27189727, "end_pos": 27199629, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031551", "url": "https://www.ensembl.org/id/ENSBTAG00000031551" } ] } } ], "crossref": [ { "id": "A0AAA9SNZ6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNZ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031551", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031551", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511877", "url": "https://www.ncbi.nlm.nih.gov/gene/511877", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SYMCTGC", "url": "https://omabrowser.org/oma/group/SYMCTGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N116", "url": "https://www.orthodb.org/?gene=F1N116", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24253:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24253:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RXI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N116", "url": "https://www.uniprot.org/uniprotkb/F1N116", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N116-1", "url": "https://www.uniprot.org/uniprotkb/F1N116-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNSPGSHSHSPRVRNYWPSSSPAKAMTPDLLANWGWGRGGARETQVASLENQRTGSRLTWGSMKQSWRLKLFILGAVVLTEGLQAAQRACGQRGPGPPEPQEGNTMPGEWPWQASVRRQGIHICSGSLVADIWVLTAAHCFEKEAMTELNSWSVVLGSLQHEGLSPGAEEVGVTALQLPRAYNHYSQGSDLALLRLAHPIAHTPLCLPRPAHRFPFGTSCWATGWYQHTNDAPRTLRNLRLRLISRPTCNCLYNRLHQRSLASPARPGMLCGGPQPGMQGPCQGDSGGPVLCREPDGHWVQAGIISFASSCAREDTPVLLTDMAAHSSWLQARAQGAAFLTQNPETPEISDEDSCVACGSLRREGPQAGAPSPWPWDARLKHQGKLACGGALVSEEVVLTAAHCFIGRQTPEEWTVGLGVGPEESGLKQVILHGAYTHPEGGYDVALLLLAQPVTLGPSLRPLCLPYSDHRLPDGERGWVLGLARQGADTGSPQTVPVTLLGPRACSRLHAALGSILPGMVCTSVVGEPPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFAALPTYENWVSSLDWQVYFAEEPEPEPEPEPEPGSCTANMSAVPGTLGQGSPARRGRSAQLPSGTARPAAAGSPSVASGGPSGPCGWSRSWRRWDNCTGLSHGCAGGSGGCPHGGRSARTARSERADLPGTACGSPHPHCAPGGPAGGWPAASAGGRPSRTQHSGNAGDRRGCAGGS", "length": 747, "header": "tr|A0AAA9SNZ6-1|A0AAA9SNZ6_BOVIN Isoform 1 of Serine protease 53 OS=Bos taurus OX=9913 GN=PRSS53 PE=4 SV=1 CANONICAL=A0AAA9SNZ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6/entry#A0AAA9RXI3-1", "sequence": { "sequence": "MLNSPGSHSHSPRVRNYWPSSSPAKAMTPDLLANWGWGRGGARETQVASLENQRTGSRLTWGSMKQSWRLKLFILGAVVLTEGLQAAQRACGQRGPGPPEPQEGNTMPGEWPWQASVRRQGIHICSGSLVADIWVLTAAHCFEKEAMTELNSWSVVLGSLQHEAHTPLCLPRPAHRFPFGTSCWATGWYQHTNDAPRTLRNLRLRLISRPTCNCLYNRLHQRSLASPARPGMLCGGPQPGMQGPCQGDSGGPVLCREPDGHWVQAGIISFASSCAREDTPVLLTDMAAHSSWLQARAQGAAFLTQNPETPEISDEDSCVACGSLRREGPQAGAPSPWPWDARLKHQGKLACGGALVSEEVVLTAAHCFIGRQTPEEWTVGLGVGPEESGLKQVILHGAYTHPEGGYDVALLLLAQPVTLGPSLRPLCLPYSDHRLPDGERGWVLGLARQGADTGSPQTVPVTLLGPRACSRLHAALGSILPGMVCTSVVGEPPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFAALPTYENWVSSLDWQVYFAEEPEPEPEPEPEPGSCTANMSQPANC", "length": 578, "header": "tr|A0AAA9RXI3-1|A0AAA9SNZ6_BOVIN Computationally mapped isoform of Serine protease 53 OS=Bos taurus OX=9913 GN=PRSS53 PE=4 SV=1 CANONICAL=A0AAA9SNZ6-1" }, "locus": { "chromosome": "25", "start_pos": 27199265, "end_pos": 27194323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116267.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116267.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078214.1" } ] } }, { "isoform_ac": "A0AAA9SNG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6/entry#A0AAA9SNG7-1", "sequence": { "sequence": "MLNSPGSHSHSPRVRNYWPSSSPAKAMTPDLLANWGWGRGGARETQVASLENQRTGSRLTWGSMKQSWRLKLFILGAVVLTEGLQAAQRACGQRGPGPPEPQEGNTMPGEWPWQASVRRQGIHICSGSLVADIWVLTAAHCFEKEAMTELNSWSVVLGSLQHEGLSPGAEEVGVTALQLPRAYNHYSQGSDLALLRLAHPIAHTPLCLPRPAHRFPFGTSCWATGWYQHTNDAPRTLRNLRLRLISRPTCNCLYNRLHQRSLASPARPGMLCGGPQPGMQGPCQGDSGGPVLCREPDGHWVQAGIISFASSCAREDTPVLLTDMAAHSSWLQARAQGAAFLTQNPETPEISDEDSCVACGSLRREGPQAGAPSPWPWDARLKHQGKLACGGALVSEEVVLTAAHCFIGRQTPEEWTVGLGVGPEESGLKQVILHGAYTHPEGGYDVALLLLAQPVTLGPSLRPLCLPYSDHRLPDGERGWVLGLARQGADTGSPQTVPVTLLGPRACSRLHAALGSILPGMVCTSVVGEPPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFAALPTYENWVSSLDWQVYFAEEPEPEPEPEPEPGSCTANMSQPANC", "length": 616, "header": "tr|A0AAA9SNG7-1|A0AAA9SNG7_BOVIN Computationally mapped isoform of Serine protease 53 OS=Bos taurus OX=9913 GN=PRSS53 PE=4 SV=1 CANONICAL=A0AAA9SNZ6-1" }, "locus": { "chromosome": "25", "start_pos": 27199265, "end_pos": 27194323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087868.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087868.1" } ] } }, { "isoform_ac": "A0AAA9SNZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6/entry#A0AAA9SNZ6-1", "sequence": { "sequence": "MLNSPGSHSHSPRVRNYWPSSSPAKAMTPDLLANWGWGRGGARETQVASLENQRTGSRLTWGSMKQSWRLKLFILGAVVLTEGLQAAQRACGQRGPGPPEPQEGNTMPGEWPWQASVRRQGIHICSGSLVADIWVLTAAHCFEKEAMTELNSWSVVLGSLQHEGLSPGAEEVGVTALQLPRAYNHYSQGSDLALLRLAHPIAHTPLCLPRPAHRFPFGTSCWATGWYQHTNDAPRTLRNLRLRLISRPTCNCLYNRLHQRSLASPARPGMLCGGPQPGMQGPCQGDSGGPVLCREPDGHWVQAGIISFASSCAREDTPVLLTDMAAHSSWLQARAQGAAFLTQNPETPEISDEDSCVACGSLRREGPQAGAPSPWPWDARLKHQGKLACGGALVSEEVVLTAAHCFIGRQTPEEWTVGLGVGPEESGLKQVILHGAYTHPEGGYDVALLLLAQPVTLGPSLRPLCLPYSDHRLPDGERGWVLGLARQGADTGSPQTVPVTLLGPRACSRLHAALGSILPGMVCTSVVGEPPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFAALPTYENWVSSLDWQVYFAEEPEPEPEPEPEPGSCTANMSAVPGTLGQGSPARRGRSAQLPSGTARPAAAGSPSVASGGPSGPCGWSRSWRRWDNCTGLSHGCAGGSGGCPHGGRSARTARSERADLPGTACGSPHPHCAPGGPAGGWPAASAGGRPSRTQHSGNAGDRRGCAGGS", "length": 747, "header": "tr|A0AAA9SNZ6-1|A0AAA9SNZ6_BOVIN Isoform 1 of Serine protease 53 OS=Bos taurus OX=9913 GN=PRSS53 PE=4 SV=1 CANONICAL=A0AAA9SNZ6-1" }, "locus": { "chromosome": "25", "start_pos": 27199265, "end_pos": 27190547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131162.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131162.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085676.1" } ] } }, { "isoform_ac": "F1N116-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6/entry#F1N116-1", "sequence": { "sequence": "MLNSPGSHSHSPRVRNYWPSSSPAKAMTPDLLANWGWGRGGARETQVASLENQRTGSRLTWGSMKQSWRLKLFILGAVVLTEGTVIMPVCVPCALIGLSPSTMALGLQAAQRACGQRGPGPPEPQEGNTMPGEWPWQASVRRQGIHICSGSLVADIWVLTAAHCFEKEAMTELNSWSVVLGSLQHEGLSPGAEEVGVTALQLPRAYNHYSQGSDLALLRLAHPIAHTPLCLPRPAHRFPFGTSCWATGWYQHTNDAPRTLRNLRLRLISRPTCNCLYNRLHQRSLASPARPGMLCGGPQPGMQGPCQGDSGGPVLCREPDGHWVQAGIISFASSCAREDTPVLLTDMAAHSSWLQARAQGAAFLTQNPETPEISDEDSCVACGSLRREGPQAGAPSPWPWDARLKHQGKLACGGALVSEEVVLTAAHCFIGRQTPEEWTVGLGVGPEESGLKQVILHGAYTHPEGGYDVALLLLAQPVTLGPSLRPLCLPYSDHRLPDGERGWVLGLARQGADTGSPQTVPVTLLGPRACSRLHAALGSILPGMVCTSVVGEPPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFAALPTYENWVSSLDWQVYFAEEPEPEPEPEPEPGSCTANMSQPANC", "length": 639, "header": "tr|F1N116-1|A0AAA9SNZ6_BOVIN Computationally mapped isoform of Serine protease 53 OS=Bos taurus OX=9913 GN=PRSS53 PE=4 SV=4 CANONICAL=A0AAA9SNZ6-1" }, "locus": { "chromosome": "25", "start_pos": 27199265, "end_pos": 27194323, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044725.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044725.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042196.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042196.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A1ZA34-1", "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "Dmel\\CG30091", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCRAWVVLFAWMLTAGRGSARLLDEDCGVPMQLIPKIVGGVDAGELKNPWMALIKTNDEFICGGSVITNKFVLTAAHCMCTDEECIVKYTQLTVTLGVYHLLATGEHNHPHEIYNVERVYIHDSFAIQNYRNDIALLRLQKSIVYKPQIKPLCILLNDQLKPQTDLIQEFTAIGWGVTGNGKMSNNLQMVKIYRIDRKMCEAAFWYTFDYPMFCAGTAVGRDTCKRDSGGPLYIHMLFDGIKRATQLGIVSTGTEDCRGFGMYTDVMGHIDFIERIVLDADIEVVLPYIDLLDAGCLGNDTLNSWDRSGPDAIRSFEWLAEVYKDSFIISNGALISKTFVVTTAQLISESTALKVQLGQGDVHTYAVASVHKHPKFVSLAQNDIALLKLGEEVQYTESIRPICLPSLSNKAEQQKFQRRAADPALNLIAVGWGTPTNVVVRRTNASKCYREDHQDIGEQQLCMESPSPHLLRVGIGSPLVNPLTHGNRRAFSLVGLASFGRLEPFASNVYTNVLEYLDWIGEMVKA", "length": 526 }, "evidence": [ { "id": "A0AAA9SNZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SNZ6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1RIR5-1", "protein_name": "Serine protease 53", "gene_name": "PRSS53", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKQSWGPGLLILGAVVLIEGLQAAQRVCGQRGPGPPEPQEGNTVPGEWPWQASVRRQGLHLCSGSLVADTWVLTAAHCFEREAMTDLNSWSVVLGSLQHEGLSTGAEEVGVTALQLPRAYNHYSQGADLALLQLAHPVAHTPLCLPQPGHRFPFGTSCWATGWDQDPKDAPRTLRNLRLRLISRPTCNCLYDRLHQRLLASPARPGMLCGGPQPGVQGPCQGDSGGPVLCREADGHWVQAGIISFASSCAQEDTPVLLTDMAAHSSWLQARAQGAAFLAQNPEAPEMSDEDSCVACGSLKRGSPQAGAPSPWPWDARLKHQGKLACGGALVSEEVVLTAAHCFIGRQAPEEWTVGLGARSEERGLRQVILHGAYTHPEGGYDVALLLLAQPVTLGPSLRPLCLPYADHRLPDGEHGWVLGLARKGADTGSPQTVPVTLLGPRACSRLHATFGGDSVPILPGMVCTSVVGKPPGCEGLSGAPLVHEVRDRWFLAGLHSFGDACQGPTSPAAVFAALPTYENWVSSLDWQVYFAEEPEPEAEPGSCPANMSQPAGC", "length": 554 }, "evidence": [ { "id": "A0AAA9SNZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SNZ6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2L4Q9-1", "protein_name": "Serine protease 53", "gene_name": "PRSS53", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC", "length": 553 }, "evidence": [ { "id": "A0AAA9SNZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SNZ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q571E5-1", "protein_name": "Serine protease 53", "gene_name": "Prss53", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRQSWRPELLIVGAVVVIEGLQAAQRACGQRGPGPPEPQEGNTLPGEWPWQASVRRQGVHICSGSLVADTWVLTAAHCFEKMATAELSSWSVVLGSLKQEGQSPGAEEVGVAALQLPKAYNHYSQGSDLALLQLTHPTVQTTLCLPQPTYHFPFGASCWATGWDQNTSDVSRTLRNLRLRLISRPTCNCLYNRLHQRLLSNPARPGMLCGGAQPGEQGPCQGDSGGPVMCREPDGHWVQVGIISFTSKCAQEDTPVLLTDMAVHSSWLQAHVHEAAFLVQAPGVVKMSDENSCVACGSLRSAGPQAGALSQWPWDARLKHHGKLACGGALVSEVVVLTAAHCFIGRQTLEEWSVGLGAGPEEWGLKQLILHGAYTHPEGGYDVAFLLLAQPVTLGPGLRPLCLPYADHHLPDGEHGWVLGLTQKAGINYPQTVPVTVLGPMACSRQHAAPGGTGIPILPGMVCTTVVGEPPHCEGLSGAPLVHEIRGTWFLVGLHSFGDTCQSSAKPAVFAALSAYEDWISNLDWQVYFAEEPEPEAETGSCLVNSSQPASC", "length": 552 }, "evidence": [ { "id": "A0AAA9SNZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SNZ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6TEK4-1", "protein_name": "Vitamin K epoxide reductase complex subunit 1", "gene_name": "Vkorc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTTWRSPGRLRLALCLAGLALSLYALHVKAARARNEDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGADSILNQSNSIFGCMFYTIQLLLGCLRGRWASILLILSSLVSVAGSLYLAWILFFVLYDFCIVCITTYAINAGLMLLSFQKVPEHKVKKP", "length": 161 }, "evidence": [ { "id": "A0AAA9SNZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SNZ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ6" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 336, "start_aa": "Ile", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 609, "end_pos": 611 }, { "start_pos": 666, "end_pos": 668 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRR2-1", "uniprot_ac": "A0AAA9SRR2", "uniprot_id": "A0AAA9SRR2_BOVIN", "mass": { "chemical_mass": 164227.0, "monoisotopic_mass": 164227.0 }, "refseq": { "ac": "NP_001422121", "name": "collagen alpha-4(IV) chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121" }, "gene_names": [ { "name": "COL4A4", "type": "recommended", "evidence": [ { "id": "A0AAA9SRR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ] }, { "name": "COL4A4", "type": "synonym", "evidence": [ { "id": "NP_001422121", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121" } ] } ], "protein_names": [ { "name": "Collagen type IV alpha 4 chain", "type": "synonym", "evidence": [ { "id": "A0AAA9SRR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2/entry#names_and_taxonomy" } ] }, { "name": "alpha type IV collagen basement membrane", "type": "synonym", "evidence": [ { "id": "NP_001422121", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121" } ] }, { "name": "collagen alpha-4(IV) chain precursor", "type": "synonym", "evidence": [ { "id": "NP_001422121", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121" } ] }, { "name": "collagen alpha-4(IV) chain", "type": "synonym", "evidence": [ { "id": "NP_001422121", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121" } ] }, { "name": "collagen, type IV, alpha 4", "type": "synonym", "evidence": [ { "id": "NP_001422121", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121" } ] } ], "function": [ { "annotation": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RY74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY74#function" }, { "database": "UniProtKB", "id": "ARBA00003696", "url": "https://www.uniprot.org/uniprotkb/ARBA00003696#function" }, { "database": "UniProtKB", "id": "A0AAA9S921", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S921#function" }, { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2#function" }, { "database": "UniProtKB", "id": "F1MJ71", "url": "https://www.uniprot.org/uniprotkb/F1MJ71#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL4A4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2", "locus": { "chromosome": "2", "start_pos": 115161378, "end_pos": 115317902, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021310", "url": "https://www.ensembl.org/id/ENSBTAG00000021310" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021310", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021310", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "407107", "url": "https://www.ncbi.nlm.nih.gov/gene/407107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MJ71", "url": "https://www.orthodb.org/?gene=F1MJ71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01413", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001422121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422121", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RY74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S921", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S921", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S921-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S921-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ71", "url": "https://www.uniprot.org/uniprotkb/F1MJ71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ71-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALVRRPFKCNKLLATNSWSLILILFSVQYAYGGGKKFIGLCGGRDCSLCQCFPEKGSRGQPGPAGPQGPIGPLGPPGPTGIPGEKGMKGDSGRPGAAGDVGDKGPTGVPGFPGLDGIPGHPGPPGSRGRPGIDGYNGSRGDPGIPGERGALGPRGPPGLPGEKGEKGNSVFILGATKGMQGDRGDPGPPGSPGSRGVRGPAGPVGYPGEPGLAGPPGPPGSPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVQPPDSGLYKGEKGIKGMPGMTGLPGPPGPRGEPGIGRKGEKGIPGFPGPRGDPGSYGSPGFPGLKGEPGLFGDPGSFGFLGPKGDPGDRGHPGPPGVLVTPSLPLKGPPGDPGRPGRYGETGAVGPRGPPGAPGRPGEACPGMTGPPGPRGFPGHPGFPGAAGVPGRADSAPGKPGNQGPTGLPGVPGLPGPPGSDAVYCTVGQPGPQGTKGKVGPPGRRGSKGEKGSSGLCACQPGPMGPSGPPGPPGRQGSKGDLGLPGWLGEKGSPGPPGAKGSPGPPGKPGASGLPGSKGEKGDMVVSRVKGHKGERGPDGPPGLPGQQGQHGRDGYAGEKGDTGPPGDHEDAAPGDKGPPGPPGPPGRAGPRGPPGLGFPGPPGDRGQPGAPGYPGNRGPDGRKGRKGDTIPCNVTYPGRPGPPGFDGPPGPKGLPGHRGAPGLRCLDGQKGQRGKPGISERPGPPGFRGDIGEPGLGGEKGSSPVGPPGTPGSPGVNGQKGPPGDPAIGYPGLPGKSGLPGAPGSKGLRGDAGRPGTAGPAGMPGFPGLQGPKGREGNAGFPGIPGPPGHSCERGAPGIPGQPGLPGAPGSPGAPGWKGQRGDMGPLGPAGMKGLPGVPGWPGADGTPGLPGVPGPTGDDGLPGLPGPKGPQGLPGFLGFPGERGKPGQDGHPGRKGEHGEKGWPGFLGDRGLKGVKGARGPPGYEGETDIISKKGETGEPGPSGDGGFPGENGDKGHPGMQGRRGEPGSHGPPGFHPGEPGRNGQPGLPGPPGPPGSPGLRGNIGFPGFPGDQGEPGSPGCPGPSGMDGTRGPKGDKGESASQFGLPGPKGEPGGPGYPGRLGASGEQGLPGAQGPGGPPGRPGPPGLSGPTGCPGSPGGPGLQGPPGEVGDPGPRGVLGDPGAPGLPGIKGPSGSPGLNGLHGLKGQKGSKGASGSHEMGPPGPVGMPGPKGETGDPGNPGISPPGLFGERGPLGPPGPPGRAGPPGPPGAPGKALKGDIPDPGLPGDQGPPGPDGPRGVPGPPGPPGSVDLLKGEPGDCGLPGPPGLPGPPGPPGHKGFPGCDGKHGQKGPMGFPGPQGPPGSPGPPGDKGLPGPPGRRGPLGPPGSRGEPGPPADLDACPRIPGLPGVPGPRGPEGTMGLPGMRGPPGPGCKGEPGLDGRRGEDGLPGSPGPPGHKGDMGEAGCPGAPGPPGPMGDPGPIGFGPGYLSGFLLVLHSQTDGEPTCPMGMPRLWTGYSLLYLEGQERAHNQDLGLAGSCLPIFSTLPFAYCNIHQVCHYARRNDRSYWLASTAPLPMTPLSEDEIRPYISRCAVCEAPAQAVAVHSQDQSIPPCPRAWRSLWIGYSFLMHTGAGDQGGGQALMSPGSCLEDFRAAPFLECQGRQGTCHFFANKYSFWLTTVRPDLQFSSAPLPDTLKESHAQRQKISRCQVCVKHS", "length": 1689, "header": "tr|A0AAA9SRR2-1|A0AAA9SRR2_BOVIN Isoform 1 of Collagen type IV alpha 4 chain OS=Bos taurus OX=9913 GN=COL4A4 PE=4 SV=1 CANONICAL=A0AAA9SRR2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2/entry#A0AAA9RY74-1", "sequence": { "sequence": "MALVRRPFKCNKLLATNSWSLILILFSVQYAYGGGKKFIGLCGGRDCSLCQCFPEKGSRGQPGPAGPQGPIGPLGPPGPTGIPGEKGMKGDSGRPGAAGDVGDKGPTGVPGFPGLDGIPGHPGPPGSRGRPGIDGYNGSRGDPGIPGERGALGPRGPPGLPGEKGEKGNSVFILGATKGMQGDRGDPGPPGSPGSRGVRGPAGPVGYPGEPGLAGPPGPPGSPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVQPPDSGLYKGEKGIKGMPGMTGLPGPPGPRGEPGIGRKGEKGIPGFPGPRGDPGSYGSPGFPGLKGEPGLFGDPGSFGFLGPKGDPGDRGHPGPPGVLVTPSLPLKGPPGDPGRPGRYGETGAVGPRGPPGAPGRPGEACPGMTGPPGPRGFPGHPGFPGAAGVPGRADSAPGKPGNQGPTGLPGVPGLPGPPGSDAVYCTVGQPGPQGTKGKVGPPGRRGSKGEKGSSGLCACQPGPMGPSGPPGPPGRQGSKGDLGLPGWLGEKGSPGPPGAKGSPGPPGKPGASGLPGSKGEKGDMVVSRVKGHKGERGPDGPPGLPGQQGQHGRDGYAGEKGDTGPPGDHEDAAPGDKGPPGPPGPPGRAGPRGPPGLGFPGPPGDRGQPGAPGYPGNRGPDGRKGRKGDTIPCNVTYPGRPGPPGFDGPPGPKGLPGHRGAPGLRCLDGQKGQRGKPGISERPGPPGFRGDIGEPGLGGEKGSSPVGPPGTPGSPGVNGQKGPPGDPAIGYPGLPGKSGLPGAPGSKGLRGDAGRPGTAGPAGMPGFPGLQGPKGREGNAGFPGIPGPPGHSCERGAPGIPGQPGLPGAPGSPGAPGWKGQRGDMGPLGPAGMKGLPGVPGWPGADGTPGLPGVPGPTGDDGLPGLPGPKGPQGLPGFLGFPGERGKPGQDGHPGRKGEHGEKGWPGFLGDRGLKGVKGARGPPGYEGETDIISKKGETGEPGPSGDGGFPGENGDKGHPGMQGRRGEPGSHGPPGFHPGEPGRNGQPGLPGPPGPPGSPGLRGNIGFPGFPGDQGEPGSPGCPGPSGMDGTRGPKGDKGESASQFGLPGPKGEPGGPGYPGRLGASGEQGLPGAQGPGGPPGRPGPPGLSGPTGCPGSPGGPGLQGPPGEVGDPGPRGVLGDPGAPGLPGIKGPSGSPGLNGLHGLKGQKGSKGASGSHEMGPPGPVGMPGPKGETGDPGNPGISPPGLFGERGPLGPPGPPGRAGPPGPPGAPGKALKGDIPDPGLPGDQGPPGPDGPRGVPGPPGPPGSVDLLKGEPGDCGLPGPPGLPGPPGPPGHKGFPGCDGKHGQKGPMGFPGPQGPPGSPGPPGDKGLPGPPGRRGPLGPPGSRGEPGPPADLDACPRIPGLPGVPGPRGPEGTMGLPGMRGPPGPGCKGEPGLDGRRGEDGLPGSPGPPGHKGDMGEAGCPGAPGPPGPMGDPGPIGFGPGYLSGFLLVLHSQTDGEPTCPMGMPRLWTGYSLLYLEGQERAHNQDLAHRRWGPRRRAGPHVPRQLPRGFQSRTVPGMPRPAGNLPLFCQQV", "length": 1551, "header": "tr|A0AAA9RY74-1|A0AAA9SRR2_BOVIN Computationally mapped isoform of Collagen type IV alpha 4 chain OS=Bos taurus OX=9913 GN=COL4A4 PE=4 SV=1 CANONICAL=A0AAA9SRR2-1" }, "locus": { "chromosome": "2", "start_pos": 115302134, "end_pos": 115169048, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122262.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122262.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076073.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076073.1" } ] } }, { "isoform_ac": "A0AAA9S921-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2/entry#A0AAA9S921-1", "sequence": { "sequence": "MALVRRPFKCNKLLATNSWSLILILFSVQYAYGGGKKFIGLCGGRDCSLCQCFPEKGSRGQPGPAGPQGPIGPLGPPGPTGIPGEKGMKGDSGRPGAAGDVGDKGPTGVPGFPGLDGIPGHPGPPGSRGRPGIDGYNGSRGDPGIPGERGALGPRGPPGLPGEKGEKGNSVFILGATKGMQGDRGDPGPPGSPGSRGVRGPAGPVGYPGEPGLAGPPGPPGSPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVQPPDSGLYKGEKGIKGMPGMTGLPGPPGPRGEPGIGRKGEKGIPGFPGPRGDPGSYGSPGFPGLKGEPGLFGDPGSFGFLGPKGDPGDRGHPGPPGVLVTPSLPLKGPPGDPGRPGRYGETGAVGPRGPPGAPGRPGEACPGMTGPPGPRGFPGHPGFPGAAGVPGRADSAPGKPGNQGPTGLPGVPGLPGPPGSDAVYCTVGQPGPQGTKGKVGPPGRRGSKGEKGSSGLCACQPGPMGPSGPPGPPGRQGSKGDLGLPGWLGEKGSPGPPGAKGSPGPPGKPGASGLPGSKGEKGDMVVSRVKGHKGERGPDGPPGLPGQQGQHGRDGYAGEKGDTGPPGDHEDAAPGDKGPPGPPGPPGRAGPRGPPGLGFPGPPGDRGQPGAPGYPGNRGPDGRKGRKGDTIPCNVTYPGRPGPPGFDGPPGPKGLPGHRGAPGLRCLDGQKGQRGKPGISERPGPPGFRGDIGEPGLGGEKGSSPVGPPGTPGSPGVNGQKGPPGDPAIGYPGLPGKSGLPGAPGSKGLRGDAGRPGTAGPAGMPGFPGLQGPKGREGNAGFPGIPGPPGHSCERGAPGIPGQPGLPGAPGSPGAPGWKGQRGDMGPLGPAGMKGLPGVPGWPGADGTPGLPGVPGPTGDDGLPGLPGPKGARGPPGYEGETDIISKKGETGEPGPSGDGGFPGENGDKGHPGMQGRRGEPGSHGPPGFHPGEPGRNGQPGLPGPPGPPGSPGLRGNIGFPGFPGDQGEPGSPGCPGPSGMDGTRGPKGDKGESASQFGLPGPKGEPGGPGYPGRLGASGEQGLPGAQGPGGPPGRPGPPGLSGPTGCPGSPGGPGLQGPPGEVGDPGPRGVLGDPGAPGLPGIKGPSGSPGLNGLHGLKGQKGSKGASGSHEMGPPGPVGMPGPKGETGDPGNPGISPPGLFGERGPLGPPGPPGRAGPPGPPGAPGKALKGDIPDPGLPGDQGPPGPDGPRGVPGPPGPPGSVDLLKGEPGDCGLPGPPGLPGPPGPPGHKGFPGCDGKHGQKGPMGFPGPQGPPGSPGPPGDKGLPGPPGRRGPLGPPGSRGEPGPPADLDACPRIPGLPGVPGPRGPEGTMGLPGMRGPPGPGPPGPMGDPGPIGFGPGYLSGFLLVLHSQTDGEPTCPMGMPRLWTGYSLLYLEGQERAHNQDLGLAGSCLPIFSTLPFAYCNIHQVCHYARRNDRSYWLASTAPLPMTPLSEDEIRPYISRCAVCEAPAQAVAVHSQDQSIPPCPRAWRSLWIGYSFLMHTGAGDQGGGQALMSPGSCLEDFRAAPFLECQGRQGTCHFFANKYSFWLTTVRPDLQFSSAPLPDTLKESHAQRQKISRCQVCVKHS", "length": 1602, "header": "tr|A0AAA9S921-1|A0AAA9SRR2_BOVIN Computationally mapped isoform of Collagen type IV alpha 4 chain OS=Bos taurus OX=9913 GN=COL4A4 PE=4 SV=1 CANONICAL=A0AAA9SRR2-1" }, "locus": { "chromosome": "2", "start_pos": 115302134, "end_pos": 115168921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090247.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090247.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081785.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081785.1" } ] } }, { "isoform_ac": "A0AAA9SRR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2/entry#A0AAA9SRR2-1", "sequence": { "sequence": "MALVRRPFKCNKLLATNSWSLILILFSVQYAYGGGKKFIGLCGGRDCSLCQCFPEKGSRGQPGPAGPQGPIGPLGPPGPTGIPGEKGMKGDSGRPGAAGDVGDKGPTGVPGFPGLDGIPGHPGPPGSRGRPGIDGYNGSRGDPGIPGERGALGPRGPPGLPGEKGEKGNSVFILGATKGMQGDRGDPGPPGSPGSRGVRGPAGPVGYPGEPGLAGPPGPPGSPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVQPPDSGLYKGEKGIKGMPGMTGLPGPPGPRGEPGIGRKGEKGIPGFPGPRGDPGSYGSPGFPGLKGEPGLFGDPGSFGFLGPKGDPGDRGHPGPPGVLVTPSLPLKGPPGDPGRPGRYGETGAVGPRGPPGAPGRPGEACPGMTGPPGPRGFPGHPGFPGAAGVPGRADSAPGKPGNQGPTGLPGVPGLPGPPGSDAVYCTVGQPGPQGTKGKVGPPGRRGSKGEKGSSGLCACQPGPMGPSGPPGPPGRQGSKGDLGLPGWLGEKGSPGPPGAKGSPGPPGKPGASGLPGSKGEKGDMVVSRVKGHKGERGPDGPPGLPGQQGQHGRDGYAGEKGDTGPPGDHEDAAPGDKGPPGPPGPPGRAGPRGPPGLGFPGPPGDRGQPGAPGYPGNRGPDGRKGRKGDTIPCNVTYPGRPGPPGFDGPPGPKGLPGHRGAPGLRCLDGQKGQRGKPGISERPGPPGFRGDIGEPGLGGEKGSSPVGPPGTPGSPGVNGQKGPPGDPAIGYPGLPGKSGLPGAPGSKGLRGDAGRPGTAGPAGMPGFPGLQGPKGREGNAGFPGIPGPPGHSCERGAPGIPGQPGLPGAPGSPGAPGWKGQRGDMGPLGPAGMKGLPGVPGWPGADGTPGLPGVPGPTGDDGLPGLPGPKGPQGLPGFLGFPGERGKPGQDGHPGRKGEHGEKGWPGFLGDRGLKGVKGARGPPGYEGETDIISKKGETGEPGPSGDGGFPGENGDKGHPGMQGRRGEPGSHGPPGFHPGEPGRNGQPGLPGPPGPPGSPGLRGNIGFPGFPGDQGEPGSPGCPGPSGMDGTRGPKGDKGESASQFGLPGPKGEPGGPGYPGRLGASGEQGLPGAQGPGGPPGRPGPPGLSGPTGCPGSPGGPGLQGPPGEVGDPGPRGVLGDPGAPGLPGIKGPSGSPGLNGLHGLKGQKGSKGASGSHEMGPPGPVGMPGPKGETGDPGNPGISPPGLFGERGPLGPPGPPGRAGPPGPPGAPGKALKGDIPDPGLPGDQGPPGPDGPRGVPGPPGPPGSVDLLKGEPGDCGLPGPPGLPGPPGPPGHKGFPGCDGKHGQKGPMGFPGPQGPPGSPGPPGDKGLPGPPGRRGPLGPPGSRGEPGPPADLDACPRIPGLPGVPGPRGPEGTMGLPGMRGPPGPGCKGEPGLDGRRGEDGLPGSPGPPGHKGDMGEAGCPGAPGPPGPMGDPGPIGFGPGYLSGFLLVLHSQTDGEPTCPMGMPRLWTGYSLLYLEGQERAHNQDLGLAGSCLPIFSTLPFAYCNIHQVCHYARRNDRSYWLASTAPLPMTPLSEDEIRPYISRCAVCEAPAQAVAVHSQDQSIPPCPRAWRSLWIGYSFLMHTGAGDQGGGQALMSPGSCLEDFRAAPFLECQGRQGTCHFFANKYSFWLTTVRPDLQFSSAPLPDTLKESHAQRQKISRCQVCVKHS", "length": 1689, "header": "tr|A0AAA9SRR2-1|A0AAA9SRR2_BOVIN Isoform 1 of Collagen type IV alpha 4 chain OS=Bos taurus OX=9913 GN=COL4A4 PE=4 SV=1 CANONICAL=A0AAA9SRR2-1" }, "locus": { "chromosome": "2", "start_pos": 115302134, "end_pos": 115168921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093056.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093056.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085661.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085661.1" } ] } }, { "isoform_ac": "F1MJ71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2/entry#F1MJ71-1", "sequence": { "sequence": "MALVRRPFKCNKLLATNSWSLILILFSVQYAYGGGKKFIGLCGGRDCSLCQCFPEKGSRGQPGPAGPQGPIGPLGPPGPTGIPGEKGMKGDSGRPGAAGDVGDKGPTGVPGFPGLDGIPGHPGPPGSRGRPGIDGYNGSRGDPGIPGERGALGPRGPPGLPGEKGEKGNSVFILGATKGMQGDRGDPGPPGSPGSRGVRGPAGPVGYPGEPGLAGPPGPPGSPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVQPPDSGLYKGEKGIKGMPGMTGLPGPPGPRGEPGIGRKGEKGIPGFPGPRGDPGSYGSPGFPGLKGEPGLFGDPGSFGFLGPKGDPGDRGHPGPPGVLVTPSLPLKGPPGDPGRPGRYGETGAVGPRGPPGAPGRPGEACPGMTGPPGPRGFPGHPGFPGAAGVPGRADSAPGKPGNQGPTGLPGVPGLPGPPGSDAVYCTVGQPGPQGTKGKVGPPGRRGSKGEKGSSGLCACQPGPMGPSGPPGPPGRQGSKGDLGLPGWLGEKGSPGPPGAKGSPGPPGKPGASGLPGSKGEKGDMVVSRVKGHKGERGPDGPPGLPGQQGQHGRDGYAGEKGDTGPPGDHEDAAPGDKGPPGPPGPPGRAGPRGPPGLGFPGPPGDRGQPGAPGYPGNRGPDGRKGRKGDTIPCNVTYPGRPGPPGFDGPPGPKGLPGHRGAPGLRCLDGQKGQRGKPGISERPGPPGFRGDIGEPGLGGEKGSSPVGPPGTPGSPGVNGQKGPPGDPAIGYPGLPGKSGLPGAPGSKGLRGDAGRPGTAGPAGMPGFPGLQGPKGREGNAGFPGIPGPPGHSCERGAPGIPGQPGLPGAPGSPGAPGWKGQRGDMGPLGPAGMKGLPGVPGWPGADGTPGLPGVPGPTGDDGLPGLPGPKGPQGLPGFLGFPGERGKPGQDGHPGRKGEHGEKGWPGFLGDRGLKGVKGARGPPGYEGETDIISKKGETGEPGPSGDGGFPGENGDKGHPGMQGRRGEPGSHGPPGFHPGEPGRNGQPGLPGPPGPPGSPGLRGNIGFPGFPGDQGEPGSPGCPGPSGMDGTRGPKGDKGESASQFGLPGPKGEPGGPGYPGRLGASGEQGLPGAQGPGGPPGRPGPPGLSGPTGCPGSPGGPGLQGPPGEVGDPGPRGVLGDPGAPGLPGIKGPSGSPGLNGLHGLKGQKGSKGASGSHEMGPPGPVGMPGPKGETGDPGNPGISPPGLFGERGPLGPPGPPGRAGPPGPPGAPGKALKGDIPDPGLPGDQGPPGPDGPRGVPGPPGPPGSVDLLKGEPGDCGLPGPPGLPGPPGPPGHKGFPGCDGKHGQKGPMGFPGPQGPPGSPGPPGDKGLPGPPGRRGPLGPPGSRGEPGPPADLDACPRIPGLPGVPGPRGPEGTMGLPGMRGPPGPGCKGEPGLDGRRGEDGLPGSPGPPGHKGDMGEAGCPGAPGPPGPMGDPGPIGFGPGYLSGFLLVLHSQTDGEPTCPMGMPRLWTGYSLLYLEGQERAHNQDLGLAGSCLPIFSTLPFAYCNIHQVCHYARRNDRSYWLASTAPLPMTPLSEDEIRPYISRCAVCEAPAQAVAVHSQDQSIPPCPRAWRSLWIGYSFLMMRKLRLREDK", "length": 1612, "header": "tr|F1MJ71-1|F1MJ71_BOVIN Computationally mapped isoform of Collagen type IV alpha 4 chain OS=Bos taurus OX=9913 GN=COL4A4 PE=4 SV=4 CANONICAL=A0AAA9SRR2-1" }, "locus": { "chromosome": "2", "start_pos": 115302134, "end_pos": 115162382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018302.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018302.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018302.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018302.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 741, "start_aa": "Thr", "end_pos": 741, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr741", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 878, "start_aa": "Thr", "end_pos": 878, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr878", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 888, "start_aa": "Thr", "end_pos": 888, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr888", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ], "pmid": "" }, { "name": "collagen trimer", "id": "GO:0005581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005581", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ], "pmid": "" }, { "name": "collagen type IV trimer", "id": "GO:0005587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005587", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glomerular basement membrane development", "id": "GO:0032836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032836", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRR2" }, { "id": "PS51403", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51403" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Collagen IV NC1", "eco_id": "ECO_0000259", "start_pos": 1464, "end_pos": 1689, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 741, 878, 888 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 664, "end_pos": 666 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMV1-1", "uniprot_ac": "A0AAA9SMV1", "uniprot_id": "A0AAA9SMV1_BOVIN", "mass": { "chemical_mass": 95559.0, "monoisotopic_mass": 95559.0 }, "refseq": {}, "gene_names": [ { "name": "FBXO43", "type": "recommended", "evidence": [ { "id": "A0AAA9SMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ] } ], "protein_names": [ { "name": "F-box only protein 43", "type": "recommended", "evidence": [ { "id": "A0AAA9SMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1/entry#names_and_taxonomy" } ] }, { "name": "Endogenous meiotic inhibitor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis.", "evidence": [ { "database": "UniProtKB", "id": "F1MH26", "url": "https://www.uniprot.org/uniprotkb/F1MH26#function" }, { "database": "UniProtKB", "id": "ARBA00053796", "url": "https://www.uniprot.org/uniprotkb/ARBA00053796#function" }, { "database": "UniProtKB", "id": "A0AAA9RYT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT5#function" }, { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1#function" }, { "database": "UniProtKB", "id": "A0AAA9TAI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAI7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1", "locus": { "chromosome": "14", "start_pos": 64240418, "end_pos": 64226669, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019795", "url": "https://www.ensembl.org/id/ENSBTAG00000019795" } ] } } ], "crossref": [ { "id": "A0AAA9SMV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019795", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019795", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22171", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22171", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MH26", "url": "https://www.orthodb.org/?gene=F1MH26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15493:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15493:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH26", "url": "https://www.uniprot.org/uniprotkb/F1MH26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH26-1", "url": "https://www.uniprot.org/uniprotkb/F1MH26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLQRVGLTHSVVKNPPANVGDLGDADSIPGSGRSPGGGNGKPLVFSSGESHVRRSLAGYSPRGHSESDTTEAVEHARGCLGAVRAPAKQRRSPRAQAGPGVCGVAGRRPAGGRGGAARRGAGRLLRAGSSNRRREKAAAPRGPGVEVAIAEHPWGRGRGSSAALGRLPPTHPRPARRRGGRGRPGAPRWAGAGTPETEILKMSERHSGEAGTGAGNEVDSPIVRVKSSSFGDLCSTSSFQDSGYSELLKSCSFDNTDKELFGKKERGSTLIHEYPETSSLALTYSLESPIQRKRFVFLRKENDKTPELCETPKVSRKKHLLRRRLDISFSLLDRDVESHSSSLESCTSQVPNLEKNIPSSASGFPRQGNFSSSVTSTLRTGEVTSSSQKLRLDFSQQKTSTVDDSKDDCGLFEVECISPIQGSNFKDSITHDFSDSSLCINNENTYPELLGSSVGGTSCRTDEDIFVTPISNLVPSVKFNASRRFSPSAGVRRNISTPEDSGFNSLCLDKSEDSLSEQEGSFQELLQKHKGTLKVRDTIKKSRRLGRLRRLSTLREQGSQSETEEENQTYLSSSESTPATTSDVSESQPSSDNKSEDLSFKNLSKTPALQLVHELFMKSRRKRFQQNGAHELLEERDGGKIAVLQRVLAGLIGKKMGIEKLDILTELKYRNLKHVLAMVLDSLTAESLCSVWKVSRNWREIIVQDKKANRRRKLHITQLKTNSEGAILNVEDAATRLHLLNRSALRSVQAQARTPGFQKEQASTFSPWGEVLTPIASSSVTHLSSKQEEYVKVAKTLFIDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDVLPGSAQSKRNLKRL", "length": 875, "header": "tr|A0AAA9SMV1-1|A0AAA9SMV1_BOVIN Isoform 1 of F-box only protein 43 OS=Bos taurus OX=9913 GN=FBXO43 PE=4 SV=1 CANONICAL=A0AAA9SMV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1/entry#A0AAA9RYT5-1", "sequence": { "sequence": "MMKDEKKMMTPEKARWKQFQMETEILKMSERHSGEAGTGAGNEVDSPIVRVKSSSFGDLCSTSSFQDSGYSELLKSCSFDNTDKELFGKKERGSTLIHEYPETSSLALTYSLESPIQRKRFVFLRKENDKTPELCETPKVSRKKHLLRRRLDISFSLLDRDVESHSSSLESCTSQVPNLEKNIPSSASGFPRQGNFSSSVTSTLRTGEVTSSSQKLRLDFSQQKTSTVDDSKDDCGLFEVECISPIQGSNFKDSITHDFSDSSLCINNENTYPELLGSSVGGTSCRTDEDIFVTPISNLVPSVKFNASRRFSPSAGVRRNISTPEDSGFNSLCLDKSEDSLSEQEGSFQELLQKHKGTLKVRDTIKKSRRLGRLRRLSTLREQGSQSETEEENQTYLSSSESTPATTSDVSESQPSSDNKSEDLSFKNLSKTPALQLVHELFMKSRRKRFQQNGAHELLEERDGGKIAVLQRVLAGLIGKKMGIEKLDILTELKYRNLKHVLAMVLDSLTAESLCSVWKVSRNWREIIVQDKKANRRRKLHITQLKTNSEGAILNVEDAATRLHLLNRSALRSVQAQARTPGFQKEQASTFSPWGEVLTPIASSSVTHLSSKQEEYVKVAKTLFIDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDVLPGSAQSKRNLKRL", "length": 700, "header": "tr|A0AAA9RYT5-1|A0AAA9SMV1_BOVIN Computationally mapped isoform of F-box only protein 43 OS=Bos taurus OX=9913 GN=FBXO43 PE=4 SV=1 CANONICAL=A0AAA9SMV1-1" }, "locus": { "chromosome": "14", "start_pos": 64239414, "end_pos": 64228205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117013.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117013.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077781.1" } ] } }, { "isoform_ac": "A0AAA9SMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1/entry#A0AAA9SMV1-1", "sequence": { "sequence": "MGLQRVGLTHSVVKNPPANVGDLGDADSIPGSGRSPGGGNGKPLVFSSGESHVRRSLAGYSPRGHSESDTTEAVEHARGCLGAVRAPAKQRRSPRAQAGPGVCGVAGRRPAGGRGGAARRGAGRLLRAGSSNRRREKAAAPRGPGVEVAIAEHPWGRGRGSSAALGRLPPTHPRPARRRGGRGRPGAPRWAGAGTPETEILKMSERHSGEAGTGAGNEVDSPIVRVKSSSFGDLCSTSSFQDSGYSELLKSCSFDNTDKELFGKKERGSTLIHEYPETSSLALTYSLESPIQRKRFVFLRKENDKTPELCETPKVSRKKHLLRRRLDISFSLLDRDVESHSSSLESCTSQVPNLEKNIPSSASGFPRQGNFSSSVTSTLRTGEVTSSSQKLRLDFSQQKTSTVDDSKDDCGLFEVECISPIQGSNFKDSITHDFSDSSLCINNENTYPELLGSSVGGTSCRTDEDIFVTPISNLVPSVKFNASRRFSPSAGVRRNISTPEDSGFNSLCLDKSEDSLSEQEGSFQELLQKHKGTLKVRDTIKKSRRLGRLRRLSTLREQGSQSETEEENQTYLSSSESTPATTSDVSESQPSSDNKSEDLSFKNLSKTPALQLVHELFMKSRRKRFQQNGAHELLEERDGGKIAVLQRVLAGLIGKKMGIEKLDILTELKYRNLKHVLAMVLDSLTAESLCSVWKVSRNWREIIVQDKKANRRRKLHITQLKTNSEGAILNVEDAATRLHLLNRSALRSVQAQARTPGFQKEQASTFSPWGEVLTPIASSSVTHLSSKQEEYVKVAKTLFIDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDVLPGSAQSKRNLKRL", "length": 875, "header": "tr|A0AAA9SMV1-1|A0AAA9SMV1_BOVIN Isoform 1 of F-box only protein 43 OS=Bos taurus OX=9913 GN=FBXO43 PE=4 SV=1 CANONICAL=A0AAA9SMV1-1" }, "locus": { "chromosome": "14", "start_pos": 64239414, "end_pos": 64226671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100007.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100007.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087682.1" } ] } }, { "isoform_ac": "A0AAA9TAI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1/entry#A0AAA9TAI7-1", "sequence": { "sequence": "MSERHSGEAGTGAGNEVDSPIVRVKSSSFGDLCSTSSFQDSGYSELLKSCSFDNTDKELFGKKERGSTLIHEYPETSSLALTYSLESPIQRKRFVFLRKENDKTPELCETPKVSRKKHLLRRRLDISFSLLDRDVESHSSSLESCTSQVPNLEKNIPSSASGFPRQGNFSSSVTSTLRTGEVTSSSQKLRLDFSQQKTSTVDDSKDDCGLFEVECISPIQGSNFKDSITHDFSDSSLCINNENTYPELLGSSVGGTSCRTDEDIFVTPISNLVPSVKFNASRRFSPSAGVRRNISTPEDSGFNSLCLDKSEDSLSEQEGSFQELLQKHKGTLKVRDTIKKSRRLGRLRRLSTLREQGSQSETEEENQTYLSSSESTPATTSDVSESQPSSDNKSEDLSFKNLSKTPALQLVHELFMKSRRKRFQQNGAHELLEERDGGKIAVLQRVLAGLIGKKMGIEKLDILTELKYRNLKHVLAMVLDSLTAESLCSVWKVSRNWREIIVQDKKANRRRKLHITQLKTNSEGAILNVEDAATRLHLLNRSALRSVQAQARTPGFQKEQASTFSPWGEVLTPIASSSVTHLSSKQEEYVKVAKTLFIDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDVLPGSAQSKRNLKRL", "length": 673, "header": "tr|A0AAA9TAI7-1|A0AAA9TAI7_BOVIN Computationally mapped isoform of F-box only protein 43 OS=Bos taurus OX=9913 GN=FBXO43 PE=4 SV=1 CANONICAL=A0AAA9SMV1-1" }, "locus": { "chromosome": "14", "start_pos": 64239414, "end_pos": 64230027, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127341.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127341.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093647.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093647.1" } ] } }, { "isoform_ac": "F1MH26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1/entry#F1MH26-1", "sequence": { "sequence": "MLASKNSRFTDETEILKMSERHSGEAGTGAGNEVDSPIVRVKSSSFGDLCSTSSFQDSGYSELLKSCSFDNTDKELFGKKERGSTLIHEYPETSSLALTYSLESPIQRKRFVFLRKENDKTPELCETPKVSRKKHLLRRRLDISFSLLDRDVESHSSSLESCTSQVPNLEKNIPSSASGFPRQGNFSSSVTSTLRTGEVTSSSQKLRLDFSQQKTSTVDDSKDDCGLFEVECISPIQGSNFKDSITHDFSDSSLCINNENTYPELLGSSVGGTSCRTDEDIFVTPISNLVPSVKFNASRRFSPSAGVRRNISTPEDSGFNSLCLDKSEDSLSEQEGSFQELLQKHKGTLKVRDTIKKSRRLGRLRRLSTLREQGSQSETEEENQTYLSSSESTPATTSDVSESQPSSDNKSEDLSFKNLSKTPALQLVHELFMKSRRKRFQQNGAHELLEERDGGKIAVLQRVLAGLIGKKMGIEKLDILTELKYRNLKHVLAMVLDSLTAESLCSVWKVSRNWREIIVQDKKANRRRKLHITQLKTNSECFSIQMPDSPSTRTGILLCGAILNVEDAATRLHLLNRSALRSVQAQARTPGFQKEQASTFSPWGEVLTPIASSSVTHLSSKQEEYVKVAKTLFIDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDVLPGSAQSKRNLKRL", "length": 709, "header": "tr|F1MH26-1|F1MH26_BOVIN Computationally mapped isoform of F-box only protein 43 OS=Bos taurus OX=9913 GN=FBXO43 PE=4 SV=4 CANONICAL=A0AAA9SMV1-1" }, "locus": { "chromosome": "14", "start_pos": 64239414, "end_pos": 64227873, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046169.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046169.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043492.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043492.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 578, "start_aa": "Thr", "end_pos": 578, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr578", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "pmid": "" }, { "name": "negative regulation of meiotic nuclear division", "id": "GO:0045835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045835", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 568, "end_pos": 570, "annotation": "n_glycosylation_sequon" }, { "start_pos": 594, "end_pos": 596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 603, "end_pos": 605, "annotation": "n_glycosylation_sequon" }, { "start_pos": 742, "end_pos": 744, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMV1" }, { "id": "PS51872", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51872" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZBR-type", "eco_id": "ECO_0000259", "start_pos": 803, "end_pos": 851, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 578 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 370, "end_pos": 372 }, { "start_pos": 481, "end_pos": 483 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 568, "end_pos": 570 }, { "start_pos": 594, "end_pos": 596 }, { "start_pos": 603, "end_pos": 605 }, { "start_pos": 742, "end_pos": 744 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPL5-1", "uniprot_ac": "A0AAA9SPL5", "uniprot_id": "A0AAA9SPL5_BOVIN", "mass": { "chemical_mass": 70508.0, "monoisotopic_mass": 70508.0 }, "refseq": {}, "gene_names": [ { "name": "FARSB", "type": "recommended", "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ] } ], "protein_names": [ { "name": "Phenylalanine--tRNA ligase beta subunit", "type": "recommended", "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.20", "type": "synonym", "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#names_and_taxonomy" } ] }, { "name": "Phenylalanyl-tRNA synthetase beta subunit", "type": "synonym", "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FARSB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5", "locus": { "chromosome": "2", "start_pos": 110745339, "end_pos": 110833369, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011649", "url": "https://www.ensembl.org/id/ENSBTAG00000011649" } ] } } ], "crossref": [ { "id": "A0AAA9SPL5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10947", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10947", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10947:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10947:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03484", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03484", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18262", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18262", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19413", "url": "https://www.rhea-db.org/rhea/19413", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S083", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S083", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S083-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S083-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLW2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTVSVKRDLLFRALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNEKAHGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKTPMYKRVMPKGEIQKLIITEETAKIRPYAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKKPSDIKFKPLNKSKEYTACELMNIYKTDNQLKHYLHIIENKPLYPVIYDSKGVVLSMPPIINGNHSKITVNTKNVFIECTGTDFTKAKIVLDVIVTTFSEYCENQFTVEAAEVVFPNGKLHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADIIHACDIIEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRQDMAAAGFTEALTFALCSQEDIADKLGMDISATKAVHISNPKTAEFQVARTTLLPGLLKTLAANRKMPLPLKLFEISDIVIKDSSRDVGARNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEKKGGYAIKASEEQFHVCTHPLPKSPPSSAPSVSSSSSCLDHCNKNTGSPFSGPVFFPGRCAEIFARGQSIGKLGVLHPDVITKFELTMPCSCVEINIEPFL", "length": 629, "header": "tr|A0AAA9SPL5-1|A0AAA9SPL5_BOVIN Isoform 1 of Phenylalanine--tRNA ligase beta subunit OS=Bos taurus OX=9913 GN=FARSB PE=3 SV=1 CANONICAL=A0AAA9SPL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S083-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#A0AAA9S083-1", "sequence": { "sequence": "MGKNKFCADEEFDELCFEFGLELDEITSEKEIISKEQGNEKAHGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKTPMYKRVMPKGEIQKLIITEETAKIRPYAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKKPSDIKFKPLNKSKEYTACELMNIYKTDNQLKHYLHIIENKPLYPVIYDSKGVVLSMPPIINGNHSKITVNTKNVFIECTGTDFTKAKIVLDVIVTTFSEYCENQFTVEAAEVVFPNGKLHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADIIHACDIIEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRQDMAAAGFTEALTFALCSQEDIADKLGMDISATKAVHISNPKTAEFQVARTTLLPGLLKTLAANRKMPLPLKLFEISDIVIKDSSRDVGARNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEKKGGYAIKASEGPVFFPGRCAEIFARGQSIGKLGVLHPDVITKFELTMPCSCVEINIEPFL", "length": 577, "header": "tr|A0AAA9S083-1|A0AAA9SPL5_BOVIN Computationally mapped isoform of Phenylalanine--tRNA ligase beta subunit OS=Bos taurus OX=9913 GN=FARSB PE=3 SV=1 CANONICAL=A0AAA9SPL5-1" }, "locus": { "chromosome": "2", "start_pos": 110833086, "end_pos": 110746343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121910.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121910.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075469.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075469.1" } ] } }, { "isoform_ac": "A0AAA9SN83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#A0AAA9SN83-1", "sequence": { "sequence": "MPTVSVKRDLLFRALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNEKAHGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKTPMYKRVMPKGEIQKLIITEETAKIRPYAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKKPSDIKFKPLNKSKEYTACELMNIYKTDNQLKHYLHIIENKPLYPVIYDSKGVVLSMPPIINGNHSKITVNTKNVFIECTGTDFTKAKIVLDVIVTTFSEYCENQFTVEAAEVVFPNGKLHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADIIHACDIIEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRQDMAAAGFTEALTFALCSQEDIADKLGMDISATKAVHISNPKTAEFQVARTTLLPGLLKTLAANRKMPLPLKLFEISDIVIKDSSRDVGARNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEKKGGYAIKASEVAQVISKRHAGFAAKDSGAVRAPRPGKPSQRLGRGASMELSLQALCSSLGDVQRSLPGARASGSWGSFIPTLSPSSS", "length": 616, "header": "tr|A0AAA9SN83-1|A0AAA9SN83_BOVIN Computationally mapped isoform of Phenylalanine--tRNA ligase beta subunit OS=Bos taurus OX=9913 GN=FARSB PE=3 SV=1 CANONICAL=A0AAA9SPL5-1" }, "locus": { "chromosome": "2", "start_pos": 110820143, "end_pos": 110746390, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088494.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088494.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086787.1" } ] } }, { "isoform_ac": "A0AAA9SNM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#A0AAA9SNM1-1", "sequence": { "sequence": "MPTVSVKRDLLFRALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNEKAHGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKTPMYKRVMPKGEIQKLIITEETAKIRPYAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKKPSDIKFKPLNKSKEYTACELMNIYKTDNQLKHYLHIIENKPLYPVIYDSKGVVLSMPPIINGNHSKITVNTKNVFIECTGTDFTKAKIVLDVIVTTFSEYCENQFTVEAAEVVFPNGKLHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADIIHACDIIEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRQDMAAAGFTEALTFALCSQEDIADKLGMDISATKAVHISNPKTAEFQVARTTLLPGLLKTLAANRKMPLPLKLFEISDIVIKDSSRDVGARNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEKKGGYAIKASEVNCGENPRNGGAWWAAVFGVAQSRIGLKRLSSSSPVFFPGRCAEIFARGQSIGKLGVLHPDVITKFELTMPCSCVEINIEPFL", "length": 622, "header": "tr|A0AAA9SNM1-1|A0AAA9SNM1_BOVIN Computationally mapped isoform of Phenylalanine--tRNA ligase beta subunit OS=Bos taurus OX=9913 GN=FARSB PE=3 SV=1 CANONICAL=A0AAA9SPL5-1" }, "locus": { "chromosome": "2", "start_pos": 110820143, "end_pos": 110746343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087926.1" } ] } }, { "isoform_ac": "A0AAA9SPL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#A0AAA9SPL5-1", "sequence": { "sequence": "MPTVSVKRDLLFRALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNEKAHGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKTPMYKRVMPKGEIQKLIITEETAKIRPYAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKKPSDIKFKPLNKSKEYTACELMNIYKTDNQLKHYLHIIENKPLYPVIYDSKGVVLSMPPIINGNHSKITVNTKNVFIECTGTDFTKAKIVLDVIVTTFSEYCENQFTVEAAEVVFPNGKLHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADIIHACDIIEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRQDMAAAGFTEALTFALCSQEDIADKLGMDISATKAVHISNPKTAEFQVARTTLLPGLLKTLAANRKMPLPLKLFEISDIVIKDSSRDVGARNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEKKGGYAIKASEEQFHVCTHPLPKSPPSSAPSVSSSSSCLDHCNKNTGSPFSGPVFFPGRCAEIFARGQSIGKLGVLHPDVITKFELTMPCSCVEINIEPFL", "length": 629, "header": "tr|A0AAA9SPL5-1|A0AAA9SPL5_BOVIN Isoform 1 of Phenylalanine--tRNA ligase beta subunit OS=Bos taurus OX=9913 GN=FARSB PE=3 SV=1 CANONICAL=A0AAA9SPL5-1" }, "locus": { "chromosome": "2", "start_pos": 110820143, "end_pos": 110746343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132858.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132858.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087298.1" } ] } }, { "isoform_ac": "A0AAF6DLW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5/entry#A0AAF6DLW2-1", "sequence": { "sequence": "MLGKIEGRRRMGQQRMRWLDGITDSMDRSLADEEFDELCFEFGLELDEITSEKEIISKEQGNEKAHGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKTPMYKRVMPKGEIQKLIITEETAKIRPYAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKKPSDIKFKPLNKSKEYTACELMNIYKTDNQLKHYLHIIENKPLYPVIYDSKGVVLSMPPIINGNHSKITVNTKNVFIECTGTDFTKAKIVLDVIVTTFSEYCENQFTVEAAEVVFPNGKLHTFPELAYRKEMVRADLINKKVGIRETPENLAKLLTRMCLKSEVIGDGNQIEVEIPPTRADIIHACDIIEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELLRQDMAAAGFTEALTFALCSQEDIADKLGMDISATKAVHISNPKTAEFQVARTTLLPGLLKTLAANRKMPLPLKLFEISDIVIKDSSRDVGARNYRHLCAVYYNKNPGFEIIHGLLDRIMQLLDVPPGEKKGGYAIKASEGPVFFPGRCAEIFARGQSIGKLGVLHPDVITKFELTMPCSCVEINIEPFL", "length": 600, "header": "tr|A0AAF6DLW2-1|A0AAF6DLW2_BOVIN Computationally mapped isoform of Phenylalanine--tRNA ligase beta subunit OS=Bos taurus OX=9913 GN=FARSB PE=3 SV=1 CANONICAL=A0AAA9SPL5-1" }, "locus": { "chromosome": "2", "start_pos": 110822596, "end_pos": 110746343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015473.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015473.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015473.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015473.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "phenylalanine-tRNA ligase activity", "id": "GO:0004826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "phenylalanine-tRNA ligase complex", "id": "GO:0009328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009328", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phenylalanyl-tRNA aminoacylation", "id": "GO:0006432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006432", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" }, { "name": "protein heterotetramerization", "id": "GO:0051290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051290", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19413", "name": "", "equation": "tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SPL5-1" ], "evidence": [ { "id": "19413", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19413" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SPL5", "gene_name": "FARSB", "activity": [ { "ec_number": "6.1.1.20", "activity": "tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ] }, { "ec_number": "6.1.1.20", "activity": "", "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL5" }, { "id": "PS51483", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51483" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B5", "eco_id": "ECO_0000259", "start_pos": 302, "end_pos": 379, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.20", "ec_name": "tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.1.1.20", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.20" }, { "id": "6.1.1.20", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.20" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 }, { "start_pos": 240, "end_pos": 242 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQQ1-1", "uniprot_ac": "A0AAA9SQQ1", "uniprot_id": "A0AAA9SQQ1_BOVIN", "mass": { "chemical_mass": 24925.0, "monoisotopic_mass": 24925.0 }, "refseq": {}, "gene_names": [ { "name": "JDP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ] } ], "protein_names": [ { "name": "Jun dimerization protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SQQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JDP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1", "locus": { "chromosome": "10", "start_pos": 86655611, "end_pos": 86604474, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009451", "url": "https://www.ensembl.org/id/ENSBTAG00000009451" } ] } } ], "crossref": [ { "id": "A0AAA9SQQ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009451", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009451", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14722", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14722", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCY2", "url": "https://www.orthodb.org/?gene=E1BCY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23351", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23351", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23351:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23351:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S0X7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0X7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8V3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8V3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCY2", "url": "https://www.uniprot.org/uniprotkb/E1BCY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCY2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSCWWMSAVVVVFLEWHVLRTLWGWCSAGAPGVEHCQVSQLLSTVTCSGWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 220, "header": "tr|A0AAA9SQQ1-1|A0AAA9SQQ1_BOVIN Isoform 1 of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=2 CANONICAL=A0AAA9SQQ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#A0AAA9S0X7-1", "sequence": { "sequence": "MCPNSSWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 176, "header": "tr|A0AAA9S0X7-1|A0AAA9SQQ1_BOVIN Computationally mapped isoform of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=1 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654665, "end_pos": 86604614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134641.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134641.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079521.1" } ] } }, { "isoform_ac": "A0AAA9SQQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#A0AAA9SQQ1-1", "sequence": { "sequence": "MTSCWWMSAVVVVFLEWHVLRTLWGWCSAGAPGVEHCQVSQLLSTVTCSGWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 220, "header": "tr|A0AAA9SQQ1-1|A0AAA9SQQ1_BOVIN Isoform 1 of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=2 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654665, "end_pos": 86617247, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096849.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096849.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087683.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087683.2" } ] } }, { "isoform_ac": "A0AAA9STW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#A0AAA9STW8-1", "sequence": { "sequence": "MMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEDQPHKGKSRLMKPRRTKR", "length": 170, "header": "tr|A0AAA9STW8-1|A0AAA9STW8_BOVIN Computationally mapped isoform of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=1 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654898, "end_pos": 86621137, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087443.1" } ] } }, { "isoform_ac": "A0AAA9T8V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#A0AAA9T8V3-1", "sequence": { "sequence": "MCLHSDPFPLEAASCSLNPALPVLKCSVWSWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 200, "header": "tr|A0AAA9T8V3-1|A0AAA9T8V3_BOVIN Computationally mapped isoform of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=1 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654665, "end_pos": 86620664, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095630.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095630.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095125.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095125.1" } ] } }, { "isoform_ac": "A0AAA9TSC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#A0AAA9TSC1-1", "sequence": { "sequence": "MLTGWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 174, "header": "tr|A0AAA9TSC1-1|A0AAA9TSC1_BOVIN Computationally mapped isoform of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=1 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654665, "end_pos": 86615196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113191.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113191.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099930.1" } ] } }, { "isoform_ac": "A0AAA9TY98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#A0AAA9TY98-1", "sequence": { "sequence": "MSFLCQFGSGSLKLGFPGVASDKESACQCRRRQSRGFNPWVGKILGWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 216, "header": "tr|A0AAA9TY98-1|A0AAA9TY98_BOVIN Computationally mapped isoform of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=1 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654665, "end_pos": 86618273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101229.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101229.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102186.1" } ] } }, { "isoform_ac": "E1BCY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1/entry#E1BCY2-1", "sequence": { "sequence": "MIVSWTATPPAMMPGQIPDPSMTAGSLPGLGPLTGLPSSALTAEELKYADIRNIGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK", "length": 174, "header": "tr|E1BCY2-1|A0AAA9SQQ1_BOVIN Computationally mapped isoform of Jun dimerization protein 2 OS=Bos taurus OX=9913 GN=JDP2 PE=4 SV=2 CANONICAL=A0AAA9SQQ1-1" }, "locus": { "chromosome": "10", "start_pos": 86654665, "end_pos": 86615641, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012436.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012436.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012436.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012436.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "leucine zipper domain binding", "id": "GO:0043522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043522", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "cAMP response element binding", "id": "GO:0035497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035497", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "histone chaperone activity", "id": "GO:0140713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ1" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 129, "end_pos": 192, "start_aa": "Glu", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNG6-1", "uniprot_ac": "A0AAA9SNG6", "uniprot_id": "A0AAA9SNG6_BOVIN", "mass": { "chemical_mass": 102169.0, "monoisotopic_mass": 102169.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM8B", "type": "recommended", "evidence": [ { "id": "A0AAA9SNG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6" } ] } ], "protein_names": [ { "name": "Transmembrane protein 8B", "type": "synonym", "evidence": [ { "id": "A0AAA9SNG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM8B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6", "locus": { "chromosome": "8", "start_pos": 60028370, "end_pos": 60003420, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011445", "url": "https://www.ensembl.org/id/ENSBTAG00000011445" } ] } } ], "crossref": [ { "id": "A0AAA9SNG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "100125302", "url": "https://www.ncbi.nlm.nih.gov/gene/100125302", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100125302", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125302", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PEDTMMA", "url": "https://omabrowser.org/oma/group/PEDTMMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14319", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14319", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14319:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14319:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001096805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096805", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S1F5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1F5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1F5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1F5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQPLSRPLVLSRSGPWPPTPPSPRFPNRFQFPPGSQRMPRSRFQLRRPLQSLTWAPSQSLALLHLFPHIPARPLCQPHSQNLLKPGSQRLPLFEPPSQPLLPSHPLPLHKSLCPAQPNSLSPSVPSSLCLPKSLPLPTSHSHTPPLYQPRLRSGLQLPSALLLLLLLSVLGPGAGGLFLTDYSTCSPRKLSPFRSFASTELFHFHVPEDTFLAVWNLIIFKEQGGTFGDHCPDQSVTVYFRSGAPPVINPLHTHFPGDTAVPGVFSLTLSWTLPNRTSGIFNVSSPLPGDWFLAAHLPQAHGHISVKGLQDECQYLLQPQLIVRRLLDVAVLVPGRPSEQTLSAHNRSALYKVFVPSFTYRVSAQLVCVGGRGASACPLTLRLRPKAPPLHNSSSVACGGASVCQLELALPPWGHWVYVRVETPSRGPGRTIRFQLCVWLQECPQPSLSRAVVPGAAMNMPQSLGNQPLPPEPPSLRTPAEGPGATSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNVSSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLTVSAASRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFCLCPGSLIAGSAILLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDRRVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS", "length": 930, "header": "tr|A0AAA9SNG6-1|A0AAA9SNG6_BOVIN Isoform 1 of Transmembrane protein 8B OS=Bos taurus OX=9913 GN=TMEM8B PE=3 SV=1 CANONICAL=A0AAA9SNG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1F5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6/entry#A0AAA9S1F5-1", "sequence": { "sequence": "MAQPLSRPLVLSRSGPWPPTPPSPRFPNRFQFPPGSQRMPRSRFQLRRPLQSLTWAPSQSLALLHLFPHIPARPLCQPHSQNLLKPGSQRLPLFEPPSQPLLPSHPLPLHKSLCPAQPNSLSPSVPSSLCLPKSLPLPTSHSHTPPLYQPRLRSGLQLPSALLLLLLLSVLGPGAGGLFLTDYSTCSPRKLSPFRSFASTELFHFHVPEDTFLAVWNLIIFKEQGGTFGDHCPDQSVTVRGNPFVLLVGLQDECQYLLQPQLIVRRLLDVAVLVPGRPSEQTLSAHNRSALYKVFVPSFTYRVSAQLVCVGGRGASACPLTLRLRPKAPPLHNSSSVACGGASVCQLELALPPWGHWVYVRVETPSRGPGRTIRFQLCVWLQECPQPSLSRAVVPGAAMNMPQSLGNQPLPPEPPSLRTPAEGPGATSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNVSSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLTVSAASRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFCLCPGSLIAGSAILLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDRRVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS", "length": 870, "header": "tr|A0AAA9S1F5-1|A0AAA9SNG6_BOVIN Computationally mapped isoform of Transmembrane protein 8B OS=Bos taurus OX=9913 GN=TMEM8B PE=3 SV=1 CANONICAL=A0AAA9SNG6-1" }, "locus": { "chromosome": "8", "start_pos": 60027281, "end_pos": 60003644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107238.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107238.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078826.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078826.1" } ] } }, { "isoform_ac": "A0AAA9SNG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6/entry#A0AAA9SNG6-1", "sequence": { "sequence": "MAQPLSRPLVLSRSGPWPPTPPSPRFPNRFQFPPGSQRMPRSRFQLRRPLQSLTWAPSQSLALLHLFPHIPARPLCQPHSQNLLKPGSQRLPLFEPPSQPLLPSHPLPLHKSLCPAQPNSLSPSVPSSLCLPKSLPLPTSHSHTPPLYQPRLRSGLQLPSALLLLLLLSVLGPGAGGLFLTDYSTCSPRKLSPFRSFASTELFHFHVPEDTFLAVWNLIIFKEQGGTFGDHCPDQSVTVYFRSGAPPVINPLHTHFPGDTAVPGVFSLTLSWTLPNRTSGIFNVSSPLPGDWFLAAHLPQAHGHISVKGLQDECQYLLQPQLIVRRLLDVAVLVPGRPSEQTLSAHNRSALYKVFVPSFTYRVSAQLVCVGGRGASACPLTLRLRPKAPPLHNSSSVACGGASVCQLELALPPWGHWVYVRVETPSRGPGRTIRFQLCVWLQECPQPSLSRAVVPGAAMNMPQSLGNQPLPPEPPSLRTPAEGPGATSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNVSSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLTVSAASRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFCLCPGSLIAGSAILLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDRRVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS", "length": 930, "header": "tr|A0AAA9SNG6-1|A0AAA9SNG6_BOVIN Isoform 1 of Transmembrane protein 8B OS=Bos taurus OX=9913 GN=TMEM8B PE=3 SV=1 CANONICAL=A0AAA9SNG6-1" }, "locus": { "chromosome": "8", "start_pos": 60027281, "end_pos": 60003644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099993.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099993.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084397.1" } ] } }, { "isoform_ac": "A0AAA9T7I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6/entry#A0AAA9T7I6-1", "sequence": { "sequence": "MAQPLSRPLVLSRSGPWPPTPPSPRFPNRFQFPPGSQRMPRSRFQLRRPLQSLTWAPSQSLALLHLFPHIPARPLCQPHSQNLLKPGSQRLPLFEPPSQPLLPSHPLPLHKSLCPAQPNSLSPSVPSSLCLPKSLPLPTSHSHTPPLYQPRLRSGLQLPSALLLLLLLSVLGPGAGGLFLTDYSTCSPRKLSPFRSFASTELFHFHVPEDTFLAVWNLIIFKEQGGTFGDHCPDQSVTVYFRSGAPPVINPLHTHFPGDTAVPGVFSLTLSWTLPNRTSGIFNVSSPLPGDWFLAAHLPQAHGHISVKGLQDECQYLLQPQLIVRRLLDVAVLVPGRPSEQTLSAHNRSALYKVFVPSFTYRVSAQLVCVGGRGASACPLTLRLRPKAPPLHNSSSVACGGASVCQLELALPPWGHWVYVRVETPSRGPGRTIRFQLCVWLQECPQPSLSRAVVPGAAMNMPQSLGNQPLPPEPPSLRTPAEGPGATSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNVSSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLTVSAASRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQTVRSVRRRHCYPPTWRRWLFCLCPGSLIAGSAILLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDRRVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS", "length": 891, "header": "tr|A0AAA9T7I6-1|A0AAA9T7I6_BOVIN Computationally mapped isoform of Transmembrane protein 8B OS=Bos taurus OX=9913 GN=TMEM8B PE=3 SV=1 CANONICAL=A0AAA9SNG6-1" }, "locus": { "chromosome": "8", "start_pos": 60027281, "end_pos": 60003644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094706.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094706.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 20, "start_aa": "Thr", "end_pos": 20, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr20", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100125302", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125302", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NDV4-1", "protein_name": "Transmembrane protein 8B", "gene_name": "TMEM8B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNMPQSLGNQPLPPEPPSLGTPAEGPGTTSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFAMRLLPVLDSGGVLSLELQLNASSVRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVLLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDHGVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS", "length": 472 }, "evidence": [ { "id": "A0AAA9SNG6", "url": "https://omabrowser.org/oma/group/A0AAA9SNG6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B1AWJ5-1", "protein_name": "Transmembrane protein 8B", "gene_name": "Tmem8b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNMPQSLGTQPLPPEPPSLGTPIEGSGAIAPTEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNASSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLSVSATSRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVIKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVLLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDRRVPSGARARGCGYQLCINEQEELGLVGPGGTTVSSICVS", "length": 472 }, "evidence": [ { "id": "A0AAA9SNG6", "url": "https://omabrowser.org/oma/group/A0AAA9SNG6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D4AD81-1", "protein_name": "Transmembrane protein 8B", "gene_name": "Tmem8b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQPLSRPLILSQSQPWPPATPSSRFPNLSRPRPVSQRMPRSSSPFQPRSLSPAWPLSPPRPLFHPLSQFPAQHLPLSHSQRLLKPLAQPQPLIPSPSHPLLPSHLLPLFEPRCSVQRHPIAQSLPPSLCLPKSLPLGPRLSHTLPLSQPRLRSGLQLPPALLLLLLFSVLGPGAGGLFLTDYSTCSPRKLSPFRSFASTELFHFRVPEDTFLAVWNLIIFKEQGGTFGDHCPDQSVTVYFRSGAPPVINPLHTHFPADTAVPGVFSLTLSWTLPNRTSGIFNVSSPLPGDWFLAAHLPQAHGHISVKGLQDECQYLLQPQLIVRRLLDVAVLVPGRPSEQTLSSHNRSALYKVFVPSFTYRVSAQLVCVGGRGASVCPLTLRLRPKAPPLHNSSSVTCGGASVCQLELALPPWGHWVYVRVETPSRGPGRTVRFQLCVRLQECPQPSLSRALVPGAAMNMPQSLGTQPLSLEPPSLGTPIEGSGAMAPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFALRLLPVLDSGGVLSLELQLNASSLRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLSVSVTSRVARLRIPFPQTGTWFLTLRSLCGVGPRFVRCRNATAEVRLRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVIKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVLLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDHRVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS", "length": 930 }, "evidence": [ { "id": "A0AAA9SNG6", "url": "https://omabrowser.org/oma/group/A0AAA9SNG6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QFD4-1", "protein_name": "Transmembrane protein 8B isoform X1", "gene_name": "si:dkey-84j12.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MWWLEGFRSGTRRLEILLLVYTLLCCVGDCLFVTDYFTRTPRKLNAYRSFASVELFHFNVPDDTVVAVWNLITFKEQGGTFGDSCPDRNVTVYFRSGAPPVINPLQTRFPKDTIVPGSFAVTLTWTLPNRTTGVFNVTSPLPGDWFLAAHLPKDEGKISVKGLHEECQYLFQPQLIVQRLIGISVLYPGYFIDQMIPLHNRSVLYKVFIPNYISRVKVQLVDCNTKNRSGESCPVLLKIRSRAPPVHNSSAMDCRENVPCELEVPLPSWEQWYYILVERYLSSSDVYFRIGVQVKDCSKPTVSKGSSAMNMPQSFGTAMGFSLSETLPAASLPNVPQNASDQASLLAAEDSITYLAPTADTNKCWPIRPTLRNELDTFSVHFYIFFGPNISIPPDRAAIFAINLMPVLDSGGVLNMELKLNVSSVKGENITIFGCLNHGMPLSLHDNTSVSCESESVSGFHLSINNTSNITKLRIPYPQTGTWYLSLRSLCATEHGFEMCTNVTAEVYLRSYLTPCINDCGTYGQCKLLRTNNYLYAACECKAGWDGWGCTDNTEAYSYGFQLLSTLLLCLSNLMFVPPVTIAIRSHYLLEASVYIFTMFFSTFYHACDQPGIVVFCIMEYDVLQFCDFLGSLMSVWVTVIAMARLKSIIKQVLYLLGAMALSMALQLDRHGLWNLLGPSLFALGIMAIAWTVRTIRRRRCYPPTWKRWVFFLFPGTTIATSAVALYAFVETEENYFYIHSIWHMLIAGSVGFLLPPRAKPDVKVSPLKRRRGCGYQLCVNEHEEMGLVDPAIITINSICTS", "length": 802 }, "evidence": [ { "id": "A0AAA9SNG6", "url": "https://omabrowser.org/oma/group/A0AAA9SNG6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" }, { "start_pos": 558, "end_pos": 560, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG6" }, { "id": "PS00022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00022" }, { "id": "PS01186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 667, "end_pos": 678, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 20 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 276, "end_pos": 278 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 393, "end_pos": 395 }, { "start_pos": 550, "end_pos": 552 }, { "start_pos": 558, "end_pos": 560 }, { "start_pos": 630, "end_pos": 632 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRY7-1", "uniprot_ac": "A0AAA9SRY7", "uniprot_id": "A0AAA9SRY7_BOVIN", "mass": { "chemical_mass": 48591.0, "monoisotopic_mass": 48591.0 }, "refseq": { "ac": "NP_001421891", "name": "m7GpppN-mRNA hydrolase isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421891" }, "gene_names": [ { "name": "DCP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] }, { "name": "DCP2", "type": "synonym", "evidence": [ { "id": "NP_001421891", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421891" } ] } ], "protein_names": [ { "name": "m7GpppN-mRNA hydrolase", "type": "recommended", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.62", "type": "synonym", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7/entry#names_and_taxonomy" } ] }, { "name": "DCP2 decapping enzyme homolog", "type": "synonym", "evidence": [ { "id": "NP_001421891", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421891" } ] }, { "name": "m7GpppN-mRNA hydrolase isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421891", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421891" } ] }, { "name": "mRNA-decapping enzyme 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S442", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S442#function" }, { "database": "UniProtKB", "id": "ARBA00060003", "url": "https://www.uniprot.org/uniprotkb/ARBA00060003#function" }, { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7", "locus": { "chromosome": "10", "start_pos": 994926, "end_pos": 1055295, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000767", "url": "https://www.ensembl.org/id/ENSBTAG00000000767" } ] } } ], "crossref": [ { "id": "A0AAA9SRY7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000767", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000767", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03672", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03672", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539770", "url": "https://www.ncbi.nlm.nih.gov/gene/539770", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YICKEDY", "url": "https://omabrowser.org/oma/group/YICKEDY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3MYZ4", "url": "https://www.orthodb.org/?gene=G3MYZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23114:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23114:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00293", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00293", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-430039", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450385", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450385", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450513", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450513", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450604", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450604", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421891", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "67484", "url": "https://www.rhea-db.org/rhea/67484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S442", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S442", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S442-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S442-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYZ4", "url": "https://www.uniprot.org/uniprotkb/G3MYZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYZ4-1", "url": "https://www.uniprot.org/uniprotkb/G3MYZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFNHCPFLLPQGEDVEKILDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPAKPTVEKLSRTKFRHSQQLFPEGSPGDQWVKHRQPLQHKPYSNHHAEVSDLLKAKNQSIRGNGRKQYQDSPNAKKKPNGVHSQPAKQQNPLVKCEKKLHPRKLQDTFETDAVYDSPYSGEDQLLEHAEGQAVTCNGHCKLPFSSRAFLSFKFDHNAIMKILDL", "length": 423, "header": "tr|A0AAA9SRY7-1|A0AAA9SRY7_BOVIN Isoform 1 of m7GpppN-mRNA hydrolase OS=Bos taurus OX=9913 GN=DCP2 PE=3 SV=1 CANONICAL=A0AAA9SRY7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S442-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7/entry#A0AAA9S442-1", "sequence": { "sequence": "METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFNHCPFLLPQGEDVEKILDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPAKPTVEKLSRTKFRHSQQLFPEGSPGDQWVKHRQPLQHKPYSNHHAEVSDLLKAKKCEKKLHPRKLQDTFETDAVYDSPYSGEDQLLEHAEGQAVTCNGHCKLPFSSRAFLSFKFDHNAIMKILDL", "length": 386, "header": "tr|A0AAA9S442-1|A0AAA9SRY7_BOVIN Computationally mapped isoform of m7GpppN-mRNA hydrolase OS=Bos taurus OX=9913 GN=DCP2 PE=3 SV=1 CANONICAL=A0AAA9SRY7-1" }, "locus": { "chromosome": "10", "start_pos": 1043435, "end_pos": 995930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113837.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113837.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078042.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078042.1" } ] } }, { "isoform_ac": "A0AAA9SRY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7/entry#A0AAA9SRY7-1", "sequence": { "sequence": "METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFNHCPFLLPQGEDVEKILDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPAKPTVEKLSRTKFRHSQQLFPEGSPGDQWVKHRQPLQHKPYSNHHAEVSDLLKAKNQSIRGNGRKQYQDSPNAKKKPNGVHSQPAKQQNPLVKCEKKLHPRKLQDTFETDAVYDSPYSGEDQLLEHAEGQAVTCNGHCKLPFSSRAFLSFKFDHNAIMKILDL", "length": 423, "header": "tr|A0AAA9SRY7-1|A0AAA9SRY7_BOVIN Isoform 1 of m7GpppN-mRNA hydrolase OS=Bos taurus OX=9913 GN=DCP2 PE=3 SV=1 CANONICAL=A0AAA9SRY7-1" }, "locus": { "chromosome": "10", "start_pos": 1043435, "end_pos": 995930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089146.1" } ] } }, { "isoform_ac": "G3MYZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7/entry#G3MYZ4-1", "sequence": { "sequence": "MHCSCCGSSSWRPNGWRFPAASWTISAGEDVEKILDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPAKPTVEKLSRTKFRHSQQLFPEGSPGDQWVKHRQPLQHKPYSNHHAEVSDLLKAKNQSIRGNGRKQYQDSPNAKKKPNGVHSQPAKQQNPLVKCEKKLHPRKLQDTFETDAVYDSPYSGEDQLLEHAEGQAVTCNGHCKLPFSSRAFLSFKFDHNAIMKILDL", "length": 371, "header": "tr|G3MYZ4-1|G3MYZ4_BOVIN Computationally mapped isoform of mRNA-decapping enzyme 2 OS=Bos taurus OX=9913 GN=DCP2 PE=3 SV=3 CANONICAL=A0AAA9SRY7-1" }, "locus": { "chromosome": "10", "start_pos": 1043464, "end_pos": 995930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065963.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065963.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054783.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054783.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 259, "start_aa": "Thr", "end_pos": 259, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr259", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-430039", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "resource": "Reactome", "description": "mRNA decay by 5' to 3' exoribonuclease" }, { "id": "R-BTA-450385", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450385", "resource": "Reactome", "description": "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" }, { "id": "R-BTA-450513", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450513", "resource": "Reactome", "description": "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" }, { "id": "R-BTA-450604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450604", "resource": "Reactome", "description": "KSRP (KHSRP) binds and destabilizes mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8IU60-1", "protein_name": "m7GpppN-mRNA hydrolase", "gene_name": "DCP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKPYNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKLQDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL", "length": 420 }, "evidence": [ { "id": "A0AAA9SRY7", "url": "https://omabrowser.org/oma/group/A0AAA9SRY7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CYC6-1", "protein_name": "m7GpppN-mRNA hydrolase", "gene_name": "Dcp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPKRLEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKILDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGVPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPARPTVEKLSRTKFRHSQQLFPEGSPSDQWVKHRQPLQQKSHSNHGEVSDLLKAKNQNMRGNGRKQYQDSPNQKKRANGVHGQPAKQQNPLVKCEKKLHPRKLQDNFETDATCDLPCSGEEPSVEHAEGHSVACNGHCKFPFSSRAFLSFKFDQNAIMKILDL", "length": 422 }, "evidence": [ { "id": "A0AAA9SRY7", "url": "https://omabrowser.org/oma/group/A0AAA9SRY7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "id": "GO:0000290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "negative regulation of telomere maintenance via telomerase", "id": "GO:0032211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "histone mRNA catabolic process", "id": "GO:0071044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071044", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "regulation of telomerase RNA localization to Cajal body", "id": "GO:1904872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "id": "GO:0140933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140933", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "5'-3' RNA exonuclease activity", "id": "GO:0004534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004534", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "telomerase RNA binding", "id": "GO:0070034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070034", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "RISC complex", "id": "GO:0016442", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016442", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67484", "name": "", "equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N4I7-1", "F1MLY3-1", "A0AAF6ZJ25-1", "A1A4Q9-1", "A2VE79-1", "Q3SZL6-1", "A4FUG7-1", "A0AAA9SRY7-1", "A0AAA9TYZ1-1" ], "evidence": [ { "id": "67484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67484" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SRY7", "gene_name": "DCP2", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" } ] } ] }, { "uniprot_ac": "A0AAA9TYZ1", "gene_name": "NUDT17", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A0AAA9TYZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ1" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A0AAA9TYZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ1" } ] } ] }, { "uniprot_ac": "A0AAF6ZJ25", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] }, { "ec_number": "3.6.1.64", "activity": "", "evidence": [ { "id": "A0AAF6ZJ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJ25" } ] } ] }, { "uniprot_ac": "A1A4Q9", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] } ] }, { "uniprot_ac": "A2VE79", "gene_name": "NUDT3", "activity": [ { "ec_number": "3.6.1.59", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.52", "activity": "6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.10", "activity": "[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.61", "activity": "P(1),P(6)-bis(5'-adenosyl) hexaphosphate + H2O = 2 ATP + 2 H(+).", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] }, { "ec_number": "3.6.1.52", "activity": "", "evidence": [ { "id": "A2VE79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VE79" } ] } ] }, { "uniprot_ac": "A4FUG7", "gene_name": "NUDT17", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A4FUG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUG7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A4FUG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUG7" } ] } ] }, { "uniprot_ac": "F1MLY3", "gene_name": "DCP1B", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "F1MLY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY3" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "F1MLY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY3" } ] } ] }, { "uniprot_ac": "F1N4I7", "gene_name": "DCP1A", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "F1N4I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4I7" } ] } ] }, { "uniprot_ac": "Q3SZL6", "gene_name": "DCP1B", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRY7" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 226, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.62", "ec_name": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "3.6.1.62", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62" }, { "id": "3.6.1.62", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.62" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 259 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 316, "end_pos": 318 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNP0-1", "uniprot_ac": "A0AAA9SNP0", "uniprot_id": "A0AAA9SNP0_BOVIN", "mass": { "chemical_mass": 34119.0, "monoisotopic_mass": 34119.0 }, "refseq": { "ac": "NP_001180033", "name": "transcription factor ATOH8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180033" }, "gene_names": [ { "name": "ATOH8", "type": "recommended", "evidence": [ { "id": "A0AAA9SNP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ] }, { "name": "ATOH8", "type": "synonym", "evidence": [ { "id": "NP_001180033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180033" } ] } ], "protein_names": [ { "name": "Protein atonal homolog 8", "type": "recommended", "evidence": [ { "id": "A0AAA9SNP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0/entry#names_and_taxonomy" } ] }, { "name": "atonal homolog 8", "type": "synonym", "evidence": [ { "id": "NP_001180033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180033" } ] }, { "name": "transcription factor ATOH8", "type": "synonym", "evidence": [ { "id": "NP_001180033", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180033" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATOH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0", "locus": { "chromosome": "11", "start_pos": 49083730, "end_pos": 49126218, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024000", "url": "https://www.ensembl.org/id/ENSBTAG00000024000" } ] } } ], "crossref": [ { "id": "A0AAA9SNP0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024000", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024000", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616225", "url": "https://www.ncbi.nlm.nih.gov/gene/616225", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616225", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616225", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RSWKPVC", "url": "https://omabrowser.org/oma/group/RSWKPVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MPZ6", "url": "https://www.orthodb.org/?gene=F1MPZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19290:SF102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19290:SF102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180033", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SE08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPZ6", "url": "https://www.uniprot.org/uniprotkb/F1MPZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPZ6-1", "url": "https://www.uniprot.org/uniprotkb/F1MPZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKHIPVLQDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEHGATATNGLRDRTQRLQPVPTPVPARVAPAVPSGGGADTAGERGGARAPEVLDPRKRGFALGAVGPGLPTPPPPPPPPAPQGQVPGGPETQPFREPGLRPRILLCAPPARPTPSAPPAPPEPSVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE", "length": 317, "header": "tr|A0AAA9SNP0-1|A0AAA9SNP0_BOVIN Isoform 1 of Protein atonal homolog 8 OS=Bos taurus OX=9913 GN=ATOH8 PE=4 SV=1 CANONICAL=A0AAA9SNP0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0/entry#A0AAA9SE08-1", "sequence": { "sequence": "MKHIPVLQDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEHGATATNGLRDRTQRLQPVPTPVPARVAPAVPSGGGADTAGERGGARAPEVLDPRKRGFALGAVGPGLPTPPPPPPPPAPQGQVPGGPETQPFREPGLRPRILLCAPPARPTPSAPPAPPEPSVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKARILEWVAMPSSRGSSRPRDQTYVSCVSCIGRSDQPWARLRMLLWALFPSQA", "length": 368, "header": "tr|A0AAA9SE08-1|A0AAA9SNP0_BOVIN Computationally mapped isoform of Protein atonal homolog 8 OS=Bos taurus OX=9913 GN=ATOH8 PE=4 SV=1 CANONICAL=A0AAA9SNP0-1" }, "locus": { "chromosome": "11", "start_pos": 49126019, "end_pos": 49084709, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108197.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108197.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083635.1" } ] } }, { "isoform_ac": "A0AAA9SNP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0/entry#A0AAA9SNP0-1", "sequence": { "sequence": "MKHIPVLQDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEHGATATNGLRDRTQRLQPVPTPVPARVAPAVPSGGGADTAGERGGARAPEVLDPRKRGFALGAVGPGLPTPPPPPPPPAPQGQVPGGPETQPFREPGLRPRILLCAPPARPTPSAPPAPPEPSVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE", "length": 317, "header": "tr|A0AAA9SNP0-1|A0AAA9SNP0_BOVIN Isoform 1 of Protein atonal homolog 8 OS=Bos taurus OX=9913 GN=ATOH8 PE=4 SV=1 CANONICAL=A0AAA9SNP0-1" }, "locus": { "chromosome": "11", "start_pos": 49126019, "end_pos": 49084767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109539.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109539.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086967.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086967.1" } ] } }, { "isoform_ac": "A0AAA9SWR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0/entry#A0AAA9SWR8-1", "sequence": { "sequence": "MKHIPVLQDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEHGATATNGLRDRTQRLQPVPTPVPARVAPAVPSGGGADTAGERGGARAPEVLDPRKRGFALGAVGPGLPTPPPPPPPPAPQGQVPGGPETQPFREPGLRPRILLCAPPARPTPSAPPAPPEPSVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQELAGESLSWRFPLLLTFSAHGRGAVLLIRAEAVQAGHPEDRLQLHPVPGAAGRPRLQRRPQQPQLLRVRAALHPHPAGRGPRQEAQGVTSHGLA", "length": 346, "header": "tr|A0AAA9SWR8-1|A0AAA9SWR8_BOVIN Computationally mapped isoform of Atonal bHLH transcription factor 8 OS=Bos taurus OX=9913 GN=ATOH8 PE=4 SV=1 CANONICAL=A0AAA9SNP0-1" }, "locus": { "chromosome": "11", "start_pos": 49126019, "end_pos": 49084747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130636.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130636.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088509.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088509.1" } ] } }, { "isoform_ac": "F1MPZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0/entry#F1MPZ6-1", "sequence": { "sequence": "MKHIPVLQDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEHGATATNGLRDRTQRLQPVPTPVPARVAPAVPSGGGADTAGERGGARAPEVLDPRKRGFALGAVGPGLPTPPPPPPPPAPQGQVPGGPETQPFREPGLRPRILLCAPPARPTPSAPPAPPEPSVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKFSPQSMGMWKHR", "length": 328, "header": "tr|F1MPZ6-1|F1MPZ6_BOVIN Computationally mapped isoform of Protein atonal homolog 8 OS=Bos taurus OX=9913 GN=ATOH8 PE=4 SV=3 CANONICAL=A0AAA9SNP0-1" }, "locus": { "chromosome": "11", "start_pos": 49126019, "end_pos": 49110348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033053.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033053.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032978.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032978.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 163, "start_aa": "Thr", "end_pos": 163, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr163", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 72, "start_aa": "Thr", "end_pos": 72, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr72", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616225", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616225", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AA26-1", "protein_name": "Protein atonal homolog 8", "gene_name": "Atoh8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFRLDLEAPEFGATASATAATNGLRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIRAPEVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEVQPLREQALRPRILLCAPPARPTPSAPLAPPAVPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE", "length": 322 }, "evidence": [ { "id": "A0AAA9SNP0", "url": "https://omabrowser.org/oma/group/A0AAA9SNP0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SVB9-1", "protein_name": "Protein atonal homolog 8", "gene_name": "ATOH8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEHGATATNGLRDRTQRLQPVPTPVPVRVAPAVPSGGGADTAVERGGARAPEVLDARKRGFPLGAVGPGLPTPPPPPPTPQGQVPGGPEAQPFREPGLRPRILLCAPPARPTPSAPPAPPESSVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAATSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE", "length": 315 }, "evidence": [ { "id": "A0AAA9SNP0", "url": "https://omabrowser.org/oma/group/A0AAA9SNP0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96SQ7-1", "protein_name": "Transcription factor ATOH8", "gene_name": "ATOH8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE", "length": 321 }, "evidence": [ { "id": "A0AAA9SNP0", "url": "https://omabrowser.org/oma/group/A0AAA9SNP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99NA2-1", "protein_name": "Transcription factor Atoh8", "gene_name": "Atoh8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFRLDLEAPELGATVSTTAATNGLRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIRAPEVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEAHSFREQALRPRILLCAPPARPTQSAPLAPPAAPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE", "length": 322 }, "evidence": [ { "id": "A0AAA9SNP0", "url": "https://omabrowser.org/oma/group/A0AAA9SNP0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell migration", "id": "GO:0010595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell proliferation", "id": "GO:0001937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001937", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell differentiation", "id": "GO:0045603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045603", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "formation of primary germ layer", "id": "GO:0001704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001704", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "tube formation", "id": "GO:0035148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035148", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "myoblast proliferation", "id": "GO:0051450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051450", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "positive regulation of SMAD protein signal transduction", "id": "GO:0060391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060391", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "positive regulation of miRNA transcription", "id": "GO:1902895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902895", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "anatomical structure formation involved in morphogenesis", "id": "GO:0048646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048646", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP0" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 226, "end_pos": 278, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 72, 163 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 292, "end_pos": 294 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQZ6-1", "uniprot_ac": "A0AAA9SQZ6", "uniprot_id": "A0AAA9SQZ6_BOVIN", "mass": { "chemical_mass": 165204.0, "monoisotopic_mass": 165204.0 }, "refseq": { "ac": "XP_005221017", "name": "G patch domain-containing protein 8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221017" }, "gene_names": [ { "name": "GPATCH8", "type": "recommended", "evidence": [ { "id": "A0AAA9SQZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" } ] }, { "name": "GPATCH8", "type": "synonym", "evidence": [ { "id": "XP_005221017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221017" } ] } ], "protein_names": [ { "name": "G patch domain-containing protein 8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005221017", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221017" } ] }, { "name": "G-patch domain containing 8", "type": "synonym", "evidence": [ { "id": "A0AAA9SQZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPATCH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6", "locus": { "chromosome": "19", "start_pos": 44190848, "end_pos": 44284815, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038316", "url": "https://www.ensembl.org/id/ENSBTAG00000038316" } ] } } ], "crossref": [ { "id": "ENSBTAG00000038316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534759", "url": "https://www.ncbi.nlm.nih.gov/gene/534759", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534759", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534759", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DHGGKKH", "url": "https://omabrowser.org/oma/group/DHGGKKH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC37", "url": "https://www.orthodb.org/?gene=E1BC37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17614:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17614:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27597", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27597", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221017", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221017", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T858", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T858", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T858-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T858-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC37", "url": "https://www.uniprot.org/uniprotkb/E1BC37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC37-1", "url": "https://www.uniprot.org/uniprotkb/E1BC37-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1509, "header": "tr|A0AAA9SQZ6-1|A0AAA9SQZ6_BOVIN Isoform 1 of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=1 CANONICAL=A0AAA9SQZ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#A0AAA9SEA1-1", "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1433, "header": "tr|A0AAA9SEA1-1|A0AAA9SQZ6_BOVIN Computationally mapped isoform of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=1 CANONICAL=A0AAA9SQZ6-1" }, "locus": { "chromosome": "19", "start_pos": 44284612, "end_pos": 44191852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091278.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091278.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083727.1" } ] } }, { "isoform_ac": "A0AAA9SQZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#A0AAA9SQZ6-1", "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1509, "header": "tr|A0AAA9SQZ6-1|A0AAA9SQZ6_BOVIN Isoform 1 of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=1 CANONICAL=A0AAA9SQZ6-1" }, "locus": { "chromosome": "19", "start_pos": 44284612, "end_pos": 44191852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134704.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134704.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086390.1" } ] } }, { "isoform_ac": "A0AAA9T858-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#A0AAA9T858-1", "sequence": { "sequence": "MGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1431, "header": "tr|A0AAA9T858-1|A0AAA9T858_BOVIN Computationally mapped isoform of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=1 CANONICAL=A0AAA9SQZ6-1" }, "locus": { "chromosome": "19", "start_pos": 44235147, "end_pos": 44191852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127112.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127112.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092993.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092993.1" } ] } }, { "isoform_ac": "A0AAA9TRL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#A0AAA9TRL8-1", "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1461, "header": "tr|A0AAA9TRL8-1|A0AAA9TRL8_BOVIN Computationally mapped isoform of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=1 CANONICAL=A0AAA9SQZ6-1" }, "locus": { "chromosome": "19", "start_pos": 44284612, "end_pos": 44191852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132763.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132763.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099672.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099672.1" } ] } }, { "isoform_ac": "A0AAA9TRS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#A0AAA9TRS6-1", "sequence": { "sequence": "MGGSWARDWENLFRDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1407, "header": "tr|A0AAA9TRS6-1|A0AAA9TRS6_BOVIN Computationally mapped isoform of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=1 CANONICAL=A0AAA9SQZ6-1" }, "locus": { "chromosome": "19", "start_pos": 44255189, "end_pos": 44191852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116222.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116222.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099739.1" } ] } }, { "isoform_ac": "E1BC37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6/entry#E1BC37-1", "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMEDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEEAGDDEKDESATNSGTSTAAACGLGSEFSTDKGGPFTAVQITNTTGLAQAPGPASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSDDGTKADEKGADQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDNSTHPKNALDSKKSSSPKPKGCIKVTASQGPEKTVSEVSEQQMETSAAEPSEPGSKAETKKPSGGDVSEHSLEIQSQKDSEIQMCESDPHKETSQATPAGRESREGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARAKGTEKPKDIGGSSKDHLQGLDPSELHKSQEEEESVQHSSGGRIDAPASGAACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHRADPEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGSGSAQDHSGRKHRGEPPASSCQRRAGTKRSSRSSHRSRPSSGDEDSDDASSRRLHQKSPSQYSEEEEEEEEEEEESGSEHSRSRSRSGRHHSSRHSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSGSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGPGEKKKEDGRGDDGKGIGPPSQNSSVGPGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSMSEEVLATPNKAGLKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNAKKCEESGLERGEEQEQSETEEGPPGNSDAPFGHQFPSEETAGPLSDPPPEEPKSEEATADHPVAPLGTPVHSDCYPGDPSISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIASDLEPFPGYAPPSGEPSIESVDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1480, "header": "tr|E1BC37-1|E1BC37_BOVIN Computationally mapped isoform of G-patch domain containing 8 OS=Bos taurus OX=9913 GN=GPATCH8 PE=4 SV=4 CANONICAL=A0AAA9SQZ6-1" }, "locus": { "chromosome": "19", "start_pos": 44284612, "end_pos": 44191852, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061184.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061184.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053787.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053787.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1360, "start_aa": "Thr", "end_pos": 1360, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1360", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 520, "start_aa": "Thr", "end_pos": 520, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr520", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534759", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534759", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G8E6-1", "protein_name": "G patch domain containing 8", "gene_name": "Gpatch8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LVDFFLRFSIFCLFFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEDGGEEDKDESSTNSGASAISSCGFGSDFSTEKGGPFTSVQITNSTGLSQASGLASQGISFGIKNNLGPPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKAEEKSSDQGVQKVGETDGGGNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGTGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDHRTHSKNAPENRKGSSPRPKGCSKAAASQGAEKTVSDVSEPQKEATVVGPSEPGGKTETKKCSGEGEGEQSVESLRESSESQMCESDPKEISQATPATKAGQGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPPISYSCNPLYFDFKLSRNKDAKAKGTEKPKDVGDSSKGHLQSPDPREPNKSKEGEQSVVLSEGRVDEPASGAACSSLTKQEPGGSHASETEDTGRSHPNKKEPSGKSHRHKKKKKHKKSSKHKRRHKADMEEKSSKAESGEKSKKRKKRKRKKNKSAPADSERGPKPEPPGSGSPAPPRRRRRARDDSQRRSLPAEEGNSGKKDDGGAGSGSQDHSGRKHKGEPPASSCQRRTSAKHSSRSSHRSQPSSGDEDSDNASSSHRPHQKSPSQYSEEEEEEEEEEEEEEEEEEEEDEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGHGKKEDGRGEDSKGAGLPSQNSNAGGTGRGSESDCSPEDKNSVTARLLLEKIQSRKVERKPNVCEEVLATPNKAGLKYKNPPQGYFGPKLPPSLGNKPVLPMIGKLPATRKSNKKCEDSALERGEEQEHSEPEEGSPRSRDAPLGHQFSSEDTAGPLSDPPPEEPKSEEATADHSVAPLGTPAHTDYPGDPAISHNYLPDPSDGDALESLDSGSQPGPVESNLLPIAPDLEHFPSYAPPSGEPSIESTDGTEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASTALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1514 }, "evidence": [ { "id": "A0AAA9SQZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SQZ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2A6A1-1", "protein_name": "G patch domain-containing protein 8", "gene_name": "Gpatch8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEDGGEEDKDESSTNSGASAVSSCGFGADFSTDKGGSFTSVQITNTTGLSQAPGLASQGISFGIKNNLGPPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGSSEDGTKADEKSSDQGVQKVGDTDGTGNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGTGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDHSAHSKSAPENRKSSSPKPQGCSKTAASPGAERTVSEASELQKEAAVAGPSEPGGKTETKKGSGGGEDEQSVESRETSESPMCESNPKDISQATPATKAGQGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDAKAKGTEKPKDVAGSSKDHLQSLDPREPNKSQEEEQDVVLSSEGRVDEPASGAACSSLNKQEPGGSHMSETEDTGRSHPSKKEPSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAAADSERGPKSEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGNSGKKDDGGGGSSCQDHSGRKHKGEPPTSSCQRRANTKHSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEEEEEEEEDEDSGSEHSRSRSRSGHRHSSHRSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYTSSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFQSGRGEGPGKKEDGRGDDSKGAGLPSQNSNTGTGRGSESDCSPEDKNSVTARLLLEKIQSRKVERKPNVCEEVLATPNKAGLKYKNPPQGYFGPKLPPSLGNKPVLPMIGKLPATRKSNKKCEESGLERGEEQEHSEPEEGSPRSSDAPFGHQFSEEAAGPLSDPPPEEPKSEEATADHSVAPLGTPAHTDCYPGDPAISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIAPDLEHFPNYAPPSGEPSIESTDGTEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASTALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1505 }, "evidence": [ { "id": "A0AAA9SQZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SQZ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3IS56-1", "protein_name": "G patch domain-containing protein 8", "gene_name": "gpatch8", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADRFSRFNEERDFQGGNHFDQYEEGQLELEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKTMQGRTDPVPIVLKYDVMGMGRMEMELDYAEDATEKRRVLEVEKEDTEELRQKYKDFAEKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKELKQREFARNVSSRSRKDGKKQEKMLRRLHELAEQRKQQDHVPGSGPMFKTTTVAVDGEKGEDSMDGVPMTVDISTDSFEEKSACGVGGQGSPRSGPSISFGFNKSSSSPTPSGGTQAPKVSVSFSFAKKAPVKLETAAAVFADHAEETVEGEEGQEEGGENTGVEDVGMTSTNDIPQAVAISLEEGGSGGGGGSEGDEEQLQPDDGGTLASTLNKLKMMMKKEEGYSGQEPQYYHYVPPAHCRVKPHFQFLLFMKASDQCDEKEDGVKDEKAEVGNDGEQKHIEVTIDTSEKDTENEPTQAQNTTPSSASAKEKADEESGSMSTGHDDTTEVESLPQPTDSKQVMSQPPDTGPRMPTGPFFPVLSKDESTTLQWPSELLEFTKAQPALSYSCNPLYFDFKLSRNKGNWAGKNSKPVKPVSTEEQEASKPEKTDSTPDTSGVACTTKTVGGPSTSQKEQSSLKVEGAERENNEQKLPSNDDVTAGSKKKKKKKHKKSGKHSKRKEKAAVEGELVNETPGGKTKKKKKHKRKKSKNKPRDAEGVAPEEEGNKDKEKAKDDKDGVATAQSSGVGATNEGVKRKRSHKMSGVEQTSAGKPSSTEEHNGTKRLKSDTNTPAASCSASAQKSLGGGQPPSSDSEEDGGSSSQRSRPPQRRSTPTREQRRHRSDDSGRSRSRSSHRGDHNHRRHRGQKSHSRSYSTSSERSSAGSSAYSRRSRSYTDSYSDYSEGRRHRSRRPSSDSDYDRRDGGRSHRRRYSSSSEEDSRSRSRSRSRRKHHRRRHQRSSSRSSSRSSWSSSARSYRRSSYSRSRSSASRSSSSTKGSPHRHGHSRRSDSSTRRRDFNRSRIYRSQSPRSSSRTQNRNSNSSSTLGTRGGGASSKEGGGAAEHRNSFTARQLLERIQSRKGGDQSGAGTKTGIKIKDPPQGYFGPKLPPALGNKSMLPLFGKLQAGKKPPLLPFTRSTDGVKSEQSKISDSSEVILVEPIREFPPPPPPPQPAVQQQKQQLEEAVSSAAVLEEPRHPSSDPPVLHESQPQYEQDPAMMMSQYQGERQDPNNHMLDGHLMGPDIGQQPTMHAYPGYPATMEDGDMGMEAEEDGLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKSFPSAAAAAANLAAAANLAPAPPPPPTALQQIHIQQPTVSAASATSITTVQHAILQHHAAATAMGIHPHTAHHPHHAQLAQVHHIPQHHLTPISLSPLGHSLGHSLGHSLGHTGLIPAHHTAFLSGQPIHIIPASALHHTPLALHHVPHAALYPTLFAPRPASAAAAAALQLHPLLHPIFSGQDLQHPPNHGS", "length": 1498 }, "evidence": [ { "id": "A0AAA9SQZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SQZ6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9UKJ3-1", "protein_name": "G patch domain-containing protein 8", "gene_name": "GPATCH8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT", "length": 1502 }, "evidence": [ { "id": "A0AAA9SQZ6", "url": "https://omabrowser.org/oma/group/A0AAA9SQZ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1073, "end_pos": 1075, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 136, "end_pos": 165, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ6" }, { "id": "PS50174", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 86, "start_aa": "Ser", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 520, 1360 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1073, "end_pos": 1075 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 268, "end_pos": 270 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 718, "end_pos": 720 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR55-1", "uniprot_ac": "A0AAA9SR55", "uniprot_id": "A0AAA9SR55_BOVIN", "mass": { "chemical_mass": 36799.0, "monoisotopic_mass": 36799.0 }, "refseq": {}, "gene_names": [ { "name": "LOC540403", "type": "recommended", "evidence": [ { "id": "A0AAA9SR55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 170 member A", "type": "synonym", "evidence": [ { "id": "A0AAA9SR55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC540403", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55", "locus": {} } ], "crossref": [ { "id": "A0AAA9SR55", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR55", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003047", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003047", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540403", "url": "https://www.ncbi.nlm.nih.gov/gene/540403", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BD87", "url": "https://www.orthodb.org/?gene=E1BD87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33517:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33517:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17734", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17734", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SHM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD87", "url": "https://www.uniprot.org/uniprotkb/E1BD87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD87-1", "url": "https://www.uniprot.org/uniprotkb/E1BD87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSPRRLPRREESLISLPGISKSQEDPPQLGCTAVARVCPQGSGEVSSASEYFSCVSSPRKLIHGGIWKLHRDSPQPRAPLAHLQEQGEMAPLSPHVSFSSPSSYKTCATSLHMNKEKRGMKIYYMRVQMKKGVAVSWEAEKPSESLEKQPRREEVTLPEDVRAGTPPSDVSTRNLLSDSEPSGEEREHEERADFDSPTPGSPTVEERPRARTPDWLVTMETGFRCMACCRVFPSLEILQEHVQNGIREGFSCHVFHLTMAQLTGNVEPENTPEEEVEDEDEDEDGEDEEQEEKENEEQQSAGEDVSLRRPWSQCPGCVFHSPKDRK", "length": 327, "header": "tr|A0AAA9SR55-1|A0AAA9SR55_BOVIN Isoform 1 of Family with sequence similarity 170 member A OS=Bos taurus OX=9913 GN=LOC540403 PE=4 SV=1 CANONICAL=A0AAA9SR55-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55/entry#A0AAA9SHM3-1", "sequence": { "sequence": "MKRRQKRKHLENEESQETAEKGGGISKSQEDPPQLGCTAVARVCPQGSGEVSSASEYFSCVSSPRKLIHGGIWKLHRDSPQPRAPLAHLQEQGEMAPLSPHVSFSSPSSYKTCATSLHMNKEKRGMKIYYMRVQMKKGVAVSWEAEKPSESLEKQPRREEVTLPEDVRQLKIMGQTILEDGVAFSWKREKKGPWRE", "length": 196, "header": "tr|A0AAA9SHM3-1|A0AAA9SR55_BOVIN Computationally mapped isoform of Family with sequence similarity 170 member A OS=Bos taurus OX=9913 GN=LOC540403 PE=4 SV=1 CANONICAL=A0AAA9SR55-1" }, "locus": { "chromosome": "7", "start_pos": 34241776, "end_pos": 34237171, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125998.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125998.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082004.1" } ] } }, { "isoform_ac": "A0AAA9SR55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55/entry#A0AAA9SR55-1", "sequence": { "sequence": "MKSPRRLPRREESLISLPGISKSQEDPPQLGCTAVARVCPQGSGEVSSASEYFSCVSSPRKLIHGGIWKLHRDSPQPRAPLAHLQEQGEMAPLSPHVSFSSPSSYKTCATSLHMNKEKRGMKIYYMRVQMKKGVAVSWEAEKPSESLEKQPRREEVTLPEDVRAGTPPSDVSTRNLLSDSEPSGEEREHEERADFDSPTPGSPTVEERPRARTPDWLVTMETGFRCMACCRVFPSLEILQEHVQNGIREGFSCHVFHLTMAQLTGNVEPENTPEEEVEDEDEDEDGEDEEQEEKENEEQQSAGEDVSLRRPWSQCPGCVFHSPKDRK", "length": 327, "header": "tr|A0AAA9SR55-1|A0AAA9SR55_BOVIN Isoform 1 of Family with sequence similarity 170 member A OS=Bos taurus OX=9913 GN=LOC540403 PE=4 SV=1 CANONICAL=A0AAA9SR55-1" }, "locus": { "chromosome": "7", "start_pos": 34241742, "end_pos": 34238243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110613.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110613.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085448.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085448.1" } ] } }, { "isoform_ac": "A0AAA9TNB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55/entry#A0AAA9TNB5-1", "sequence": { "sequence": "MKRRQKRKHLENEESQETAEKGGGISKSQEDPPQLGCTAVARVCPQGSGEVSSASEYFSCVSSPRKLIHGGIWKLHRDSPQPRAPLAHLQEQGEMAPLSPHVSFSSPSSYKTCATSLHMNKEKRGMKIYYMRVQMKKGVAVSWEAEKPSESLEKQPRREEVTLPEDVRAGTPPSDVSTRNLLSDSEPSGEEREHEERADFDSPTPGSPTVEERPRARTPDWLVTMETGFRCMACCRVFPSLEILQEHVQNGIREGFSCHVFHLTMAQLTGNVEPENTPEEEVEDEDEDEDGEDEEQEEKENEEQQSAGEDVSLRRPWSQCPGCVFHSPKDRNN", "length": 333, "header": "tr|A0AAA9TNB5-1|A0AAA9TNB5_BOVIN Computationally mapped isoform of Family with sequence similarity 170 member A OS=Bos taurus OX=9913 GN=LOC540403 PE=4 SV=1 CANONICAL=A0AAA9SR55-1" }, "locus": { "chromosome": "7", "start_pos": 34241776, "end_pos": 34237998, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122699.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122699.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100008.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100008.1" } ] } }, { "isoform_ac": "E1BD87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55/entry#E1BD87-1", "sequence": { "sequence": "MKRRQKRKHLENEESQETAEKGGGIWKLHRDSPQPRAPLAHLQEQGEMAPLSPHVSFSSPSSYKTCATSLHMNKEKRGMKIYYMRVQMKKGVAVSWEAEKPSESLEKQPRREEVTLPEDVRAGTPPSDVSTRNLLSDSEPSGEEREHEERADFDSPTPGSPTVEERPRARTPDWLVTMETGFRCMACCRVFPSLEILQEHVQNGIREGFSCHVFHLTMAQLTGNVEPENTPEEEVEDEDEDEDGEDEEQEEKENEEQQSAGEDVSLRRPWSQCPGCVFHSPKDRNN", "length": 286, "header": "tr|E1BD87-1|A0AAA9SR55_BOVIN Computationally mapped isoform of Family with sequence similarity 170 member A OS=Bos taurus OX=9913 GN=LOC540403 PE=4 SV=4 CANONICAL=A0AAA9SR55-1" }, "locus": { "chromosome": "7", "start_pos": 34241776, "end_pos": 34237998, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003964.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003964.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003964.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003964.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 199, "start_aa": "Thr", "end_pos": 199, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr199", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 199 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQU0-1", "uniprot_ac": "A0AAA9SQU0", "uniprot_id": "A0AAA9SQU0_BOVIN", "mass": { "chemical_mass": 74527.0, "monoisotopic_mass": 74527.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF710", "type": "recommended", "evidence": [ { "id": "A0AAA9SQU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ] } ], "protein_names": [ { "name": "Zinc finger protein 710", "type": "recommended", "evidence": [ { "id": "A0AAA9SQU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SHR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR6#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0#function" }, { "database": "UniProtKB", "id": "G3N0M2", "url": "https://www.uniprot.org/uniprotkb/G3N0M2#function" }, { "database": "UniProtKB", "id": "G5E5M3", "url": "https://www.uniprot.org/uniprotkb/G5E5M3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF710", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0", "locus": { "chromosome": "21", "start_pos": 21475799, "end_pos": 21402344, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019174", "url": "https://www.ensembl.org/id/ENSBTAG00000019174" } ] } } ], "crossref": [ { "id": "A0AAA9SQU0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019174", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019174", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539500", "url": "https://www.ncbi.nlm.nih.gov/gene/539500", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539500", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539500", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEMAYYS", "url": "https://omabrowser.org/oma/group/KEMAYYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N0M2", "url": "https://www.orthodb.org/?gene=G3N0M2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G5E5M3", "url": "https://www.orthodb.org/?gene=G5E5M3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818:SF139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818:SF139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SHR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0M2", "url": "https://www.uniprot.org/uniprotkb/G3N0M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0M2-1", "url": "https://www.uniprot.org/uniprotkb/G3N0M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5M3", "url": "https://www.uniprot.org/uniprotkb/G5E5M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5M3-1", "url": "https://www.uniprot.org/uniprotkb/G5E5M3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAIGEPRPPGPDVYQLACHGRALEEPAEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKVEEEEEVYEVSVPGGDDKDAGPAEAPAEAAGGGCEALVQSSAVKMIDLSVFSRKPRTLRHLPRAPRPELDVAPFDPHFPDPARDAFAEPSMALPRPEALPVECGFEPPHLPPLSDPEPPTMESPEPVKPEQGFVWQEVGEFEADAAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCQKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQDPMMELTGTDPSELDSQQEMEDFEENAYAYAGVDGSAEASVLSEQAMKEMAYYNVL", "length": 664, "header": "tr|A0AAA9SQU0-1|A0AAA9SQU0_BOVIN Isoform 1 of Zinc finger protein 710 OS=Bos taurus OX=9913 GN=ZNF710 PE=3 SV=1 CANONICAL=A0AAA9SQU0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0/entry#A0AAA9SHR6-1", "sequence": { "sequence": "MPPKDDLSRKSYTGDLPYPRIEPASPVSPALAGGFLTTGSTCDALLASRHGMEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAIGEPRPPGPDVYQLACHGRALEEPAEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKVEEEEEVYEVSVPGGDDKDAGPAEAPAEAAGGGCEALVQSSAVKMIDLSVFSRKPRTLRHLPRAPRPELDVAPFDPHFPDPARDAFAEPSMALPRPEALPVECGFEPPHLPPLSDPEPPTMESPEPVKPEQGFVWQEVGEFEADAAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCQKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQDPMMELTGTDPSELDSQQEMEDFEENAYAYAGVDGSAEASVLSEQAMKEMAYYNVL", "length": 715, "header": "tr|A0AAA9SHR6-1|A0AAA9SQU0_BOVIN Computationally mapped isoform of Zinc finger protein 710 OS=Bos taurus OX=9913 GN=ZNF710 PE=3 SV=1 CANONICAL=A0AAA9SQU0-1" }, "locus": { "chromosome": "21", "start_pos": 21473778, "end_pos": 21444439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119177.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119177.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085758.1" } ] } }, { "isoform_ac": "A0AAA9SQU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0/entry#A0AAA9SQU0-1", "sequence": { "sequence": "MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAIGEPRPPGPDVYQLACHGRALEEPAEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKVEEEEEVYEVSVPGGDDKDAGPAEAPAEAAGGGCEALVQSSAVKMIDLSVFSRKPRTLRHLPRAPRPELDVAPFDPHFPDPARDAFAEPSMALPRPEALPVECGFEPPHLPPLSDPEPPTMESPEPVKPEQGFVWQEVGEFEADAAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCQKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQDPMMELTGTDPSELDSQQEMEDFEENAYAYAGVDGSAEASVLSEQAMKEMAYYNVL", "length": 664, "header": "tr|A0AAA9SQU0-1|A0AAA9SQU0_BOVIN Isoform 1 of Zinc finger protein 710 OS=Bos taurus OX=9913 GN=ZNF710 PE=3 SV=1 CANONICAL=A0AAA9SQU0-1" }, "locus": { "chromosome": "21", "start_pos": 21473778, "end_pos": 21462642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135525.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135525.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087720.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087720.1" } ] } }, { "isoform_ac": "G3N0M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0/entry#G3N0M2-1", "sequence": { "sequence": "MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAIGEPRPPGPDVYQLACHGRALEEPAEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKVEEEEEVYEVSVPGGDDKDAGPAEAPAEAAGGGCEALVQSSAVKMIDLSVFSRKPRTLRHLPRAPRPELDVAPFDPHFPDPARDAFAEPSMALPRPEALPVECGFEPPHLPPLSDPEPPTMESPEPVKPEQGFVWQEVGEFEADAAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCQKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQGGWATRRGRSRNGPVMAHSGASCPVRGVGRLARPETSLGWAQVWREGSPEGHQRDNDGTFMYSPKDLRGLT", "length": 679, "header": "tr|G3N0M2-1|G3N0M2_BOVIN Computationally mapped isoform of Zinc finger protein 710 OS=Bos taurus OX=9913 GN=ZNF710 PE=3 SV=4 CANONICAL=A0AAA9SQU0-1" }, "locus": { "chromosome": "21", "start_pos": 21468735, "end_pos": 21462642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063144.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063144.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055388.4", "url": "https://www.ensembl.org/id/ENSBTAP00000055388.4" } ] } }, { "isoform_ac": "G5E5M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0/entry#G5E5M3-1", "sequence": { "sequence": "MGIHPVGGKEQVLPGESACAKALSDALLASRHGMEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAIGEPRPPGPDVYQLACHGRALEEPAEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKVEEEEEVYEVSVPGGDDKDAGPAEAPAEAAGGGCEALVQSSAVKMIDLSVFSRKPRTLRHLPRAPRPELDVAPFDPHFPDPARDAFAEPSMALPRPEALPVECGFEPPHLPPLSDPEPPTMESPEPVKPEQGFVWQEVGEFEADAAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCQKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQDPMMELTGTDPSELDSQQEMEDFEENAYAYAGVDGSAEASVLSEQAMKEMAYYNVL", "length": 697, "header": "tr|G5E5M3-1|G5E5M3_BOVIN Computationally mapped isoform of Zinc finger protein 710 OS=Bos taurus OX=9913 GN=ZNF710 PE=3 SV=2 CANONICAL=A0AAA9SQU0-1" }, "locus": { "chromosome": "21", "start_pos": 21473778, "end_pos": 21455844, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025518.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025518.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025518.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025518.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539500", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539500", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G6X3-1", "protein_name": "Zinc finger protein 710", "gene_name": "Zfp710", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGTAMGEPGPPGPDIYQLACNGQALEEPPEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKAEDEEEQEVYEVSVPGDDKDPGPAEAPEEAASGGCEALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRPELDTAPFDPPFPDPARDGFLEPSMALPGSETLPTECSFEPPHLAPLSNPEPPNMTSTELVKPEQGFVWQESSEFEADTAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDISLDSQDPMMELAGPDPSELDNHQEMEDFEENAYTYSSVDGSTEASALTEQAMKEMAYYNVL", "length": 665 }, "evidence": [ { "id": "A0AAA9SQU0", "url": "https://omabrowser.org/oma/group/A0AAA9SQU0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3U288-1", "protein_name": "Zinc finger protein 710", "gene_name": "Znf710", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELTGTAMGEPGPPGPDIYQLACNGRALEEPPEEEVLEVEAAFEKHTRRKTRPPVRLVPKVKFEKAEEEEEQEVYEVSVPGDDKDPGPAEAPAEVASSGCEALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRPELDMAPFDPPFPDPARDGFPEPSMALPGPETLPTECSFEPPHLAPLSNPEPPNMTSTTELVKPEQGFVWQESSEFEADTAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDISLDSQDPMMELAGPDPSELDNHQEMEDFEENAYTYSSVDSSAEASTLTEQAMKEMAYYNVL", "length": 666 }, "evidence": [ { "id": "A0AAA9SQU0", "url": "https://omabrowser.org/oma/group/A0AAA9SQU0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N1W2-1", "protein_name": "Zinc finger protein 710", "gene_name": "ZNF710", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGFMDSGTQTDAVVVLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAMGEPEPPGPDVYQLACNGRALEEPAEEEVLEVEAACEKHTRRKTRPPVRLVPKVKFEKVEEEEQEVYEVSVPGDDKDAGPAEAPAEAASGGCDALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRPELNVAPYDPHFPAPARDGFPEPSMALPGPEALPTECGFEPPHLAPLSDPEAPSMESPEPVKPEQGFVWQEASEFEADTAGSTVERHKKAQLDRLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQDPMMELTGTDPSELDGQQEMEDFEENAYSYASVDSSAEASVLTEQAMKEMAYYNVL", "length": 664 }, "evidence": [ { "id": "A0AAA9SQU0", "url": "https://omabrowser.org/oma/group/A0AAA9SQU0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 295, "end_pos": 322, "start_aa": "Trp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 589, "end_pos": 591 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNV0-1", "uniprot_ac": "A0AAA9SNV0", "uniprot_id": "A0AAA9SNV0_BOVIN", "mass": { "chemical_mass": 107698.0, "monoisotopic_mass": 107698.0 }, "refseq": {}, "gene_names": [ { "name": "MORC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SNV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ] } ], "protein_names": [ { "name": "MORC family CW-type zinc finger protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SNV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MORC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0", "locus": { "chromosome": "1", "start_pos": 53721883, "end_pos": 53887189, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060826", "url": "https://www.ensembl.org/id/ENSBTAG00000060826" } ] } } ], "crossref": [ { "id": "A0AAA9SNV0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16931", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16931", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23337", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23337", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23337:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23337:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13589", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13589", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17942", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17942", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SLS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDKYATLLRAQLHLDFIHANSTTHSFLFGALAELLDNARDAGAARLDVFSVDNEELQGGFMLCFLDDGCGMSPEEASDIIYFGTSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKKEETMTCVFFSQTFCEREGLSEVVVPIPSWLTRTRESVTDDPQKFSTELSIIYKYSPFKTEAELMQQFNVIYGKCGTLLVVYNLKLLLSGEPELDVKTDREDILMAGALGDFPERWSFRAYTSVLYFDPWMRIFIQAKRVRTKYLCYCLYRPRKYLYVTSSFKGAFKCEVKKAEEAVKRAELILKEAQIKVNHSDRTPLSSSAKDVLQKALEDVKAKQKVLQEKQRELKKARTLTLFFGVNIENRSQAGMFIYSSNRLIKMHEKVGPQLKLKSLLGEGVVGIVNIPLEIMEPSHNKQEFLNVHEYNHLLKVMGQYLVQYCKDTGISNRNLTLFWNEFGYPDNKDMEKSSDSVQYQRRQAMAIPCMIQCDLCLKWRVLPPSTNYQEKEFFDIWICANNPNLSENSCHRTEHLPSIPLGTMSTVSQSKNEKDKQLQESVQRYQNQLVEPRQQPQFIPVNRITELTSPFQASTSKGNKKIQRIRPSSDDWKHESLSSFELLVNHRGWEKNTEGADSDVEYISETEIMKKSGQKKVKPQQQMYPAVPLENVKLASRDQASWEMKRKRSQNLASIEVETSNSNSDIIPILDESDTDVPLKQEKKEVSLMKKEEKQELCSDTPEINRNSSSPNWESMPVEDLNPSSGYKARVSVSGDCKVASALTESSQSTSVKETVRKLTSNLREILLYFFPEYQLPSEFGQASLEELTACSELEQCPEQTNKKLKMCFNQICDVYMVQYEKKLKRRIQSVICDANKRAVVNEVSLGQCEKKRKLTEDKLNKLRVKLAVLLQKLQLGGPAGDLEQIDAYLEALLKEDNLLFQKAFCK", "length": 941, "header": "tr|A0AAA9SNV0-1|A0AAA9SNV0_BOVIN Isoform 1 of MORC family CW-type zinc finger protein 1 OS=Bos taurus OX=9913 GN=MORC1 PE=4 SV=1 CANONICAL=A0AAA9SNV0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0/entry#A0AAA9SLS4-1", "sequence": { "sequence": "MNTESSVDNEELQGGFMLCFLDDGCGMSPEEASDIIYFGTSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKKEETMTCVFFSQTFCEREGLSEVVVPIPSWLTRTRESVTDDPQKFSTELSIIYKYSPFKTEAELMQQFNVIYGKCGTLLVVYNLKLLLSGEPELDVKTDREDILMAGALGDFPERWSFRAYTSVLYFDPWMRIFIQAKRVRTKYLCYCLYRPRKYLYVTSSFKGAFKCEVKKAEEAVKRAELILKEAQIKVNHSDRTPLSSSAKDVLQKALEDVKAKQKVLQEKQRELKKARTLTLFFGVNIENRSQAGMFIYSSNRLIKMHEKVGPQLKLKSLLGEGVVGIVNIPLEIMEPSHNKQEFLNVHEYNHLLKVMGQYLVQYCKDTGISNRNLTLFWNEFGYPDNKDMEKSSDSVQYQRRQAMAIPCMIQCDLCLKWRVLPPSTNYQEKEFFDIWICANNPNLSENSCHRTEHLPSIPLGTMSTVSQSKNEKDKQLQESVQRYQNQLVEPRQQPQFIPVNRITELTSPFQASTSKGNKKIQRIRPSSDDWKHESLSSFELLVNHRGWEKNTEGADSDVEYISETEIMKKSGQKKVKPQQQMYPAVPLENVKLASRDQASWEMKRKRSQNLASIEVETSNSNSDIIPILDESDTDVPLKQEKKEVSLMKKEEKQELCSDTPEINRNSSSPNWESMPVEDLNPSSGYKARVSVSGDCKVASALTESSQSTSVKETVRKLTSNLREILLYFFPEYQLPSEFGQASLEELTACSELEQCPEQTNKKLKMCFNQICDVYMVQYEKKLKRRIQSVICDANKRAVVNEVSLGQCEKKRKLTEDKLNKLRVKLAVLLQKLQLGGPAGDLEQIDAYLEALLKEDNLLFQKAFCK", "length": 896, "header": "tr|A0AAA9SLS4-1|A0AAA9SNV0_BOVIN Computationally mapped isoform of MORC family CW-type zinc finger protein 1 OS=Bos taurus OX=9913 GN=MORC1 PE=4 SV=1 CANONICAL=A0AAA9SNV0-1" }, "locus": { "chromosome": "1", "start_pos": 53872785, "end_pos": 53722547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091520.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091520.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083654.1" } ] } }, { "isoform_ac": "A0AAA9SNV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0/entry#A0AAA9SNV0-1", "sequence": { "sequence": "MGDKYATLLRAQLHLDFIHANSTTHSFLFGALAELLDNARDAGAARLDVFSVDNEELQGGFMLCFLDDGCGMSPEEASDIIYFGTSKKRLSTLKFIGQYGNGLKSGSMRIGKDFILFTKKEETMTCVFFSQTFCEREGLSEVVVPIPSWLTRTRESVTDDPQKFSTELSIIYKYSPFKTEAELMQQFNVIYGKCGTLLVVYNLKLLLSGEPELDVKTDREDILMAGALGDFPERWSFRAYTSVLYFDPWMRIFIQAKRVRTKYLCYCLYRPRKYLYVTSSFKGAFKCEVKKAEEAVKRAELILKEAQIKVNHSDRTPLSSSAKDVLQKALEDVKAKQKVLQEKQRELKKARTLTLFFGVNIENRSQAGMFIYSSNRLIKMHEKVGPQLKLKSLLGEGVVGIVNIPLEIMEPSHNKQEFLNVHEYNHLLKVMGQYLVQYCKDTGISNRNLTLFWNEFGYPDNKDMEKSSDSVQYQRRQAMAIPCMIQCDLCLKWRVLPPSTNYQEKEFFDIWICANNPNLSENSCHRTEHLPSIPLGTMSTVSQSKNEKDKQLQESVQRYQNQLVEPRQQPQFIPVNRITELTSPFQASTSKGNKKIQRIRPSSDDWKHESLSSFELLVNHRGWEKNTEGADSDVEYISETEIMKKSGQKKVKPQQQMYPAVPLENVKLASRDQASWEMKRKRSQNLASIEVETSNSNSDIIPILDESDTDVPLKQEKKEVSLMKKEEKQELCSDTPEINRNSSSPNWESMPVEDLNPSSGYKARVSVSGDCKVASALTESSQSTSVKETVRKLTSNLREILLYFFPEYQLPSEFGQASLEELTACSELEQCPEQTNKKLKMCFNQICDVYMVQYEKKLKRRIQSVICDANKRAVVNEVSLGQCEKKRKLTEDKLNKLRVKLAVLLQKLQLGGPAGDLEQIDAYLEALLKEDNLLFQKAFCK", "length": 941, "header": "tr|A0AAA9SNV0-1|A0AAA9SNV0_BOVIN Isoform 1 of MORC family CW-type zinc finger protein 1 OS=Bos taurus OX=9913 GN=MORC1 PE=4 SV=1 CANONICAL=A0AAA9SNV0-1" }, "locus": { "chromosome": "1", "start_pos": 53886990, "end_pos": 53722547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084553.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084553.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ], "pmid": "" }, { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 741, "end_pos": 743, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV0" }, { "id": "PS51050", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51050" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CW-type", "eco_id": "ECO_0000259", "start_pos": 478, "end_pos": 532, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 21, "end_pos": 23 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 448, "end_pos": 450 }, { "start_pos": 518, "end_pos": 520 }, { "start_pos": 741, "end_pos": 743 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMN9-1", "uniprot_ac": "A0AAA9SMN9", "uniprot_id": "A0AAA9SMN9_BOVIN", "mass": { "chemical_mass": 28318.0, "monoisotopic_mass": 28318.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC3", "type": "recommended", "evidence": [ { "id": "A0AAA9SMN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat-containing protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SMN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9", "locus": { "chromosome": "1", "start_pos": 144430224, "end_pos": 144424302, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060080", "url": "https://www.ensembl.org/id/ENSBTAG00000060080" } ] } } ], "crossref": [ { "id": "A0AAA9SMN9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSMGPTGRQSPSSLPVPAGGPCLLLLFCLRLGASCPQNCQCPDHAGAVAVHCSARGLQEVPRDIPADTVLLKLDANKIARIPNGAFQHLHQLRELDLSQNAIETIGPAAFSGLAGGLRLLDLSHNRLRRIPKDALGKLSAKIRLAHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEYVGKPLIQALDSGVSFCSVHHKTTDVAMLVTMFGWFAMVITYVVYYVRQNQEDARRHLEYLKSLPSTPMSKDPTSSAP", "length": 260, "header": "tr|A0AAA9SMN9-1|A0AAA9SMN9_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 3 OS=Bos taurus OX=9913 GN=LRRC3 PE=3 SV=1 CANONICAL=A0AAA9SMN9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9/entry#A0AAA9SMN9-1", "sequence": { "sequence": "MVSMGPTGRQSPSSLPVPAGGPCLLLLFCLRLGASCPQNCQCPDHAGAVAVHCSARGLQEVPRDIPADTVLLKLDANKIARIPNGAFQHLHQLRELDLSQNAIETIGPAAFSGLAGGLRLLDLSHNRLRRIPKDALGKLSAKIRLAHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEYVGKPLIQALDSGVSFCSVHHKTTDVAMLVTMFGWFAMVITYVVYYVRQNQEDARRHLEYLKSLPSTPMSKDPTSSAP", "length": 260, "header": "tr|A0AAA9SMN9-1|A0AAA9SMN9_BOVIN Isoform 1 of Leucine-rich repeat-containing protein 3 OS=Bos taurus OX=9913 GN=LRRC3 PE=3 SV=1 CANONICAL=A0AAA9SMN9-1" }, "locus": { "chromosome": "1", "start_pos": 144426158, "end_pos": 144425379, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118633.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118633.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085234.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN9" }, { "id": "SM00013", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRNT", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 71, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMQ2-1", "uniprot_ac": "A0AAA9SMQ2", "uniprot_id": "A0AAA9SMQ2_BOVIN", "mass": { "chemical_mass": 19969.0, "monoisotopic_mass": 19969.0 }, "refseq": {}, "gene_names": [ { "name": "VAMP7", "type": "recommended", "evidence": [ { "id": "A0AAA9SMQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2" } ] } ], "protein_names": [ { "name": "Vesicle associated membrane protein 7", "type": "synonym", "evidence": [ { "id": "A0AAA9SMQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VAMP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2", "locus": { "chromosome": "X", "start_pos": 35332561, "end_pos": 35371072, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049615", "url": "https://www.ensembl.org/id/ENSBTAG00000049615" } ] } } ], "crossref": [ { "id": "A0AAA9SMQ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14824", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14824", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR010908", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010908", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21136:SF202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21136:SF202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIGMFHDILCMYVGKNDIRLLDWGQIILEKLK", "length": 174, "header": "tr|A0AAA9SMQ2-1|A0AAA9SMQ2_BOVIN Isoform 1 of Vesicle associated membrane protein 7 OS=Bos taurus OX=9913 GN=VAMP7 PE=3 SV=1 CANONICAL=A0AAA9SMQ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2/entry#A0AAA9SMQ2-1", "sequence": { "sequence": "MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIGMFHDILCMYVGKNDIRLLDWGQIILEKLK", "length": 174, "header": "tr|A0AAA9SMQ2-1|A0AAA9SMQ2_BOVIN Isoform 1 of Vesicle associated membrane protein 7 OS=Bos taurus OX=9913 GN=VAMP7 PE=3 SV=1 CANONICAL=A0AAA9SMQ2-1" }, "locus": { "chromosome": "X", "start_pos": 35357068, "end_pos": 35332804, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085160.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ2" }, { "id": "PS50859", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50859" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Longin", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 110, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMS0-1", "uniprot_ac": "A0AAA9SMS0", "uniprot_id": "A0AAA9SMS0_BOVIN", "mass": { "chemical_mass": 55328.0, "monoisotopic_mass": 55328.0 }, "refseq": {}, "gene_names": [ { "name": "OLFM1", "type": "recommended", "evidence": [ { "id": "A0AAA9SMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ] } ], "protein_names": [ { "name": "Olfactomedin 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OLFM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0", "locus": { "chromosome": "11", "start_pos": 105598408, "end_pos": 105560462, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052600", "url": "https://www.ensembl.org/id/ENSBTAG00000052600" } ] } } ], "crossref": [ { "id": "A0AAA9SMS0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038584", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038584", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000052600", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052600", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050605", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050605", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6Q2A1", "url": "https://www.orthodb.org/?gene=F6Q2A1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23192", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23192", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23192:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23192:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12308", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12308", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N764", "url": "https://www.uniprot.org/uniprotkb/F1N764", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N764-1", "url": "https://www.uniprot.org/uniprotkb/F1N764-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q2A1", "url": "https://www.uniprot.org/uniprotkb/F6Q2A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q2A1-1", "url": "https://www.uniprot.org/uniprotkb/F6Q2A1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAASGGTLDRSTGVLPTNEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFRQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTAVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTIKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMLDFMTTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIVIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISRLDPVSLQVLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL", "length": 484, "header": "tr|A0AAA9SMS0-1|A0AAA9SMS0_BOVIN Isoform 1 of Olfactomedin 1 OS=Bos taurus OX=9913 GN=OLFM1 PE=4 SV=1 CANONICAL=A0AAA9SMS0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0/entry#A0AAA9SMS0-1", "sequence": { "sequence": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAASGGTLDRSTGVLPTNEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFRQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTAVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTIKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMLDFMTTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIVIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISRLDPVSLQVLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL", "length": 484, "header": "tr|A0AAA9SMS0-1|A0AAA9SMS0_BOVIN Isoform 1 of Olfactomedin 1 OS=Bos taurus OX=9913 GN=OLFM1 PE=4 SV=1 CANONICAL=A0AAA9SMS0-1" }, "locus": { "chromosome": "11", "start_pos": 105597404, "end_pos": 105572534, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098831.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098831.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085181.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085181.1" } ] } }, { "isoform_ac": "F1N764-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0/entry#F1N764-1", "sequence": { "sequence": "TPGRRRRPRDMQPARKLLSLLFLVLMGTELTQVLPTNEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFRQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTAVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTIKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMLDFMTTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIVIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISRLDPVSLQVLQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVIRSDEL", "length": 466, "header": "tr|F1N764-1|F1N764_BOVIN Computationally mapped isoform of Olfactomedin 1 OS=Bos taurus OX=9913 GN=OLFM1 PE=4 SV=4 CANONICAL=A0AAA9SMS0-1" }, "locus": { "chromosome": "11", "start_pos": 105597404, "end_pos": 105560623, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061530.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061530.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053660.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053660.4" } ] } }, { "isoform_ac": "F6Q2A1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0/entry#F6Q2A1-1", "sequence": { "sequence": "MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAASGGTLDRSTGVLPTNEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFRQVEESHKQHLARQFKG", "length": 152, "header": "tr|F6Q2A1-1|F6Q2A1_BOVIN Computationally mapped isoform of Olfactomedin 1 OS=Bos taurus OX=9913 GN=OLFM1 PE=4 SV=3 CANONICAL=A0AAA9SMS0-1" }, "locus": { "chromosome": "11", "start_pos": 105581314, "end_pos": 105572534, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053763.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053763.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048556.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048556.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS0" }, { "id": "PS51132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Olfactomedin-like", "eco_id": "ECO_0000259", "start_pos": 225, "end_pos": 477, "start_aa": "Ala", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 186, "end_pos": 188 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 393, "end_pos": 395 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 472, "end_pos": 474 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMS2-1", "uniprot_ac": "A0AAA9SMS2", "uniprot_id": "A0AAA9SMS2_BOVIN", "mass": { "chemical_mass": 64114.0, "monoisotopic_mass": 64114.0 }, "refseq": { "ac": "NP_001192910", "name": "cyclin-K", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192910" }, "gene_names": [ { "name": "CCNK", "type": "recommended", "evidence": [ { "id": "A0AAA9SMS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ] }, { "name": "CCNK", "type": "synonym", "evidence": [ { "id": "NP_001192910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192910" } ] } ], "protein_names": [ { "name": "Cyclin-K", "type": "recommended", "evidence": [ { "id": "A0AAA9SMS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2/entry#names_and_taxonomy" } ] }, { "name": "cyclin-K", "type": "synonym", "evidence": [ { "id": "NP_001192910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192910" } ] } ], "function": [ { "annotation": "Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).", "evidence": [ { "database": "UniProtKB", "id": "E1BEV0", "url": "https://www.uniprot.org/uniprotkb/E1BEV0#function" }, { "database": "UniProtKB", "id": "ARBA00054991", "url": "https://www.uniprot.org/uniprotkb/ARBA00054991#function" }, { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2#function" }, { "database": "UniProtKB", "id": "G3N172", "url": "https://www.uniprot.org/uniprotkb/G3N172#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNK", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2", "locus": { "chromosome": "21", "start_pos": 64523335, "end_pos": 64493317, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018636", "url": "https://www.ensembl.org/id/ENSBTAG00000018636" } ] } } ], "crossref": [ { "id": "A0AAA9SMS2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018636", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018636", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20530", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20530", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20531", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20531", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530744", "url": "https://www.ncbi.nlm.nih.gov/gene/530744", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530744", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530744", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FVIACCR", "url": "https://omabrowser.org/oma/group/FVIACCR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEV0", "url": "https://www.orthodb.org/?gene=E1BEV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N172", "url": "https://www.orthodb.org/?gene=G3N172", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173796", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173796", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192910", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEV0", "url": "https://www.uniprot.org/uniprotkb/E1BEV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEV0-1", "url": "https://www.uniprot.org/uniprotkb/E1BEV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N172", "url": "https://www.uniprot.org/uniprotkb/G3N172", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N172-1", "url": "https://www.uniprot.org/uniprotkb/G3N172-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVAPVPPSQPPPGPEPPQPPQKDSQQPAQQPPPPPAQPPKKPSPQPSPPRQAKRAVVVSPKEENKAAEPPPPKIPKIEPTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVEASDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTSSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR", "length": 582, "header": "tr|A0AAA9SMS2-1|A0AAA9SMS2_BOVIN Isoform 1 of Cyclin-K OS=Bos taurus OX=9913 GN=CCNK PE=1 SV=1 CANONICAL=A0AAA9SMS2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2/entry#A0AAA9SMS2-1", "sequence": { "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVAPVPPSQPPPGPEPPQPPQKDSQQPAQQPPPPPAQPPKKPSPQPSPPRQAKRAVVVSPKEENKAAEPPPPKIPKIEPTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVEASDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTSSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR", "length": 582, "header": "tr|A0AAA9SMS2-1|A0AAA9SMS2_BOVIN Isoform 1 of Cyclin-K OS=Bos taurus OX=9913 GN=CCNK PE=1 SV=1 CANONICAL=A0AAA9SMS2-1" }, "locus": { "chromosome": "21", "start_pos": 64522623, "end_pos": 64507563, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108537.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108537.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087655.1" } ] } }, { "isoform_ac": "E1BEV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2/entry#E1BEV0-1", "sequence": { "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDRYILCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVAPVPPSQPPPGPEPPQPPQKDSQQPAQQPPPPPAQPPKKPSPQPSPPRQAKRAVVSAPAPHEPPPPKIPKIEPTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVEASDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTSSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR", "length": 580, "header": "tr|E1BEV0-1|A0AAA9SMS2_BOVIN Computationally mapped isoform of Cyclin-K OS=Bos taurus OX=9913 GN=CCNK PE=1 SV=2 CANONICAL=A0AAA9SMS2-1" }, "locus": { "chromosome": "21", "start_pos": 64522623, "end_pos": 64507563, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024796.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024796.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024796.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024796.5" } ] } }, { "isoform_ac": "G3N172-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2/entry#G3N172-1", "sequence": { "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVAPVPPSQPPPGPEPPQPPQKDSQQPAQQPPPPPAQPPKKPSPQPSPPRQAKRAVVVSPKEENKAAGWTPMDTTWHLRFTPLLSEPPPPKIPKIEPTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVEASDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTSSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR", "length": 600, "header": "tr|G3N172-1|G3N172_BOVIN Computationally mapped isoform of Cyclin-K OS=Bos taurus OX=9913 GN=CCNK PE=1 SV=3 CANONICAL=A0AAA9SMS2-1" }, "locus": { "chromosome": "21", "start_pos": 64522623, "end_pos": 64507563, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063128.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063128.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055600.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055600.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 282, "start_aa": "Thr", "end_pos": 282, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 505, "start_aa": "Thr", "end_pos": 505, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr505", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:530744", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530744", "resource": "KEGG Pathway" }, { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-2173796", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173796", "resource": "Reactome", "description": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6796648", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "resource": "Reactome", "description": "TP53 Regulates Transcription of DNA Repair Genes" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z286-1", "protein_name": "Cyclin-K", "gene_name": "CCNK", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKENKENSSPSVNLANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQSTPQTPTVQQSQQSQGSEQLQTQQQKESQQSSQQQQQQQQTQAQQPKKPSPQPSPPRQIKRPAAVSPKEETKTTEPPPPSKIPKIETSHPPIPPPHPPPERKPPLTTAVSMGEAEQSTTVDSVDMPKVQIPPPAHPAPVHQPPPLPHRPPPPPPTSYITGMSTTNSYMSGEGYQSLQSMMKTEGPTYGALPPAYGPPTHLPYHPHVYPPNPPPPVPPPPPASFPPPNIPPPTPGYPPPPTYNPNFPPPRLPPTHAVPPHPPPPGLGMPPASYPPPAVPPGGQPPVPPPIPPPGMPPVAGLGRATWMR", "length": 587 }, "evidence": [ { "id": "A0AAA9SMS2", "url": "https://omabrowser.org/oma/group/A0AAA9SMS2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O75909-3", "protein_name": "Cyclin-K", "gene_name": "CCNK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR", "length": 580 }, "evidence": [ { "id": "A0AAA9SMS2", "url": "https://omabrowser.org/oma/group/A0AAA9SMS2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "cyclin K-CDK12 complex", "id": "GO:0002944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "cyclin K-CDK13 complex", "id": "GO:0002945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002945", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "cyclin/CDK positive transcription elongation factor complex", "id": "GO:0008024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "positive regulation of transcription elongation by RNA polymerase II", "id": "GO:0032968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "host-mediated suppression of viral genome replication", "id": "GO:0044828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044828", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription, elongation", "id": "GO:0032786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0004693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "RNA polymerase II CTD heptapeptide repeat kinase activity", "id": "GO:0008353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008353", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" }, { "id": "SM01332", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01332" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin C-terminal", "eco_id": "ECO_0000259", "start_pos": 158, "end_pos": 291, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMS2" }, { "id": "SM00385", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00385" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-like", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 149, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 282, 505 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMX8-1", "uniprot_ac": "A0AAA9SMX8", "uniprot_id": "A0AAA9SMX8_BOVIN", "mass": { "chemical_mass": 37444.0, "monoisotopic_mass": 37444.0 }, "refseq": {}, "gene_names": [ { "name": "CENPO", "type": "recommended", "evidence": [ { "id": "A0AAA9SMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8" } ] } ], "protein_names": [ { "name": "Centromere protein O", "type": "recommended", "evidence": [ { "id": "A0AAA9SMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CENPO", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8", "locus": { "chromosome": "11", "start_pos": 74417535, "end_pos": 74433150, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015014", "url": "https://www.ensembl.org/id/ENSBTAG00000015014" } ] } } ], "crossref": [ { "id": "A0AAA9SMX8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23835", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23835", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23836", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23836", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR018464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14582:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14582:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09496", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09496", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZB46", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZB46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZB46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELANTLRQDGESRGGVLAHLERLETQVSKSRKKLEEPQNAQALEARIHELKRLRDKLRAEVKQRQARVKASTANVEPDQILEISEQEILERKQENMKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVMEKPLWIHHHSVPVFIPLEEISAKYLQTNTRHFLFVLWEYLNAYSGRKYQADRLQSDFAAFLVGPLQRNSLCNLLSFTYKVKPEGQSFPFCARLLYKDLTTTLPTDVTVTSQGTEALPSTWEEQRAAHENLFFTKPLHQVKGNIALSAPMTKVMGFQKNLSRLSGQGPFHLTRTTDKQVFRVKSTASRF", "length": 328, "header": "tr|A0AAA9SMX8-1|A0AAA9SMX8_BOVIN Isoform 1 of Centromere protein O OS=Bos taurus OX=9913 GN=CENPO PE=3 SV=1 CANONICAL=A0AAA9SMX8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8/entry#A0AAA9SMX8-1", "sequence": { "sequence": "MELANTLRQDGESRGGVLAHLERLETQVSKSRKKLEEPQNAQALEARIHELKRLRDKLRAEVKQRQARVKASTANVEPDQILEISEQEILERKQENMKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVMEKPLWIHHHSVPVFIPLEEISAKYLQTNTRHFLFVLWEYLNAYSGRKYQADRLQSDFAAFLVGPLQRNSLCNLLSFTYKVKPEGQSFPFCARLLYKDLTTTLPTDVTVTSQGTEALPSTWEEQRAAHENLFFTKPLHQVKGNIALSAPMTKVMGFQKNLSRLSGQGPFHLTRTTDKQVFRVKSTASRF", "length": 328, "header": "tr|A0AAA9SMX8-1|A0AAA9SMX8_BOVIN Isoform 1 of Centromere protein O OS=Bos taurus OX=9913 GN=CENPO PE=3 SV=1 CANONICAL=A0AAA9SMX8-1" }, "locus": { "chromosome": "11", "start_pos": 74432692, "end_pos": 74418539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086665.1" } ] } }, { "isoform_ac": "A0AAF6ZB46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8/entry#A0AAF6ZB46-1", "sequence": { "sequence": "LELITLFESSFLLPAGVLAHLERLETQVSKSRKKLEEPQNAQALEARIHELKRLRDKLRAEVKQRQARVKASTANVEPDQILEISEQEILERKQENMKAILQAYRFTGISGKLTSRGVCVCISTAFEGNLLDSYFVDLVMEKPLWIHHHSVPVFIPLEEISAKYLQTNTRHFLFVLWEYLNAYSGRKYQADRLQSDFAAFLVGPLQRNSLCNLLSFTYKVKPEGQSFPFCARLLYKDLTTTLPTDVTVTSQGTEALPSTWEEQRAAHENLFFTKPLHQVFTSFAKKGEKLDMSLVS", "length": 296, "header": "tr|A0AAF6ZB46-1|A0AAF6ZB46_BOVIN Computationally mapped isoform of Centromere protein O OS=Bos taurus OX=9913 GN=CENPO PE=3 SV=1 CANONICAL=A0AAA9SMX8-1" }, "locus": { "chromosome": "11", "start_pos": 74431750, "end_pos": 74420278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032953.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032953.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032880.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032880.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "kinetochore assembly", "id": "GO:0051382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051382", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMZ3-1", "uniprot_ac": "A0AAA9SMZ3", "uniprot_id": "A0AAA9SMZ3_BOVIN", "mass": { "chemical_mass": 5860.0, "monoisotopic_mass": 5860.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SMZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SMZ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMZ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SMZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAGDRMESSLKQRKYHSRNYFPDRVCPGLRCRNQQFPLYSQPQFPLPS", "length": 49, "header": "tr|A0AAA9SMZ3-1|A0AAA9SMZ3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SMZ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ3/entry#A0AAA9SMZ3-1", "sequence": { "sequence": "MKAGDRMESSLKQRKYHSRNYFPDRVCPGLRCRNQQFPLYSQPQFPLPS", "length": 49, "header": "tr|A0AAA9SMZ3-1|A0AAA9SMZ3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SMZ3-1" }, "locus": { "chromosome": "7", "start_pos": 52210170, "end_pos": 52209642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089721.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089721.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086682.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMZ5-1", "uniprot_ac": "A0AAA9SMZ5", "uniprot_id": "A0AAA9SMZ5_BOVIN", "mass": { "chemical_mass": 26287.0, "monoisotopic_mass": 26287.0 }, "refseq": {}, "gene_names": [ { "name": "MMAB", "type": "recommended", "evidence": [ { "id": "A0AAA9SMZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" } ] } ], "protein_names": [ { "name": "Corrinoid adenosyltransferase MMAB", "type": "recommended", "evidence": [ { "id": "A0AAA9SMZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5/entry#names_and_taxonomy" } ] }, { "name": "ATP:co(I)rrinoid adenosyltransferase MMAB", "type": "synonym", "evidence": [ { "id": "A0AAA9SMZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5#function" }, { "database": "UniProtKB", "id": "ARBA00056747", "url": "https://www.uniprot.org/uniprotkb/ARBA00056747#function" }, { "database": "UniProtKB", "id": "A0AAA9TA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA51#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MMAB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5", "locus": { "chromosome": "17", "start_pos": 63639779, "end_pos": 63628778, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005178", "url": "https://www.ensembl.org/id/ENSBTAG00000005178" } ] } } ], "crossref": [ { "id": "A0AAA9SMZ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005178", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005178", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR016030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12213", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12213", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12213:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12213:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9759218", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9759218", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "56796", "url": "https://www.rhea-db.org/rhea/56796", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Z7", "url": "https://www.uniprot.org/uniprotkb/E1B6Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Z7-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSLAGVTEVRPSRASPGGCLPSMNLEVQGQPVSSTRLRAADPLHPSRLLVCHLLSLAVCLTLPSLLPHCAHDLEGGLGEVIRIGQALLGFVMELIAEKGHPFVEELQKIQCSLQDVGSALATPRSSAREAHLKHATFEAGPILELEQWIDKYSRQLPPLTAFILPSGGKSSSALHFCRAVCRRAERRVVPLVQTGETDANVVKFLNRLSDYLFTLARYTAMKEGNPEKIYKKNDLSDRT", "length": 241, "header": "tr|A0AAA9SMZ5-1|A0AAA9SMZ5_BOVIN Isoform 1 of Corrinoid adenosyltransferase MMAB OS=Bos taurus OX=9913 GN=MMAB PE=3 SV=1 CANONICAL=A0AAA9SMZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5/entry#A0AAA9SMZ5-1", "sequence": { "sequence": "MSGSLAGVTEVRPSRASPGGCLPSMNLEVQGQPVSSTRLRAADPLHPSRLLVCHLLSLAVCLTLPSLLPHCAHDLEGGLGEVIRIGQALLGFVMELIAEKGHPFVEELQKIQCSLQDVGSALATPRSSAREAHLKHATFEAGPILELEQWIDKYSRQLPPLTAFILPSGGKSSSALHFCRAVCRRAERRVVPLVQTGETDANVVKFLNRLSDYLFTLARYTAMKEGNPEKIYKKNDLSDRT", "length": 241, "header": "tr|A0AAA9SMZ5-1|A0AAA9SMZ5_BOVIN Isoform 1 of Corrinoid adenosyltransferase MMAB OS=Bos taurus OX=9913 GN=MMAB PE=3 SV=1 CANONICAL=A0AAA9SMZ5-1" }, "locus": { "chromosome": "17", "start_pos": 63639052, "end_pos": 63631272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117462.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117462.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085261.1" } ] } }, { "isoform_ac": "A0AAA9TA51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5/entry#A0AAA9TA51-1", "sequence": { "sequence": "MAVWGPGGRLGLRGCLGARKLLCPRFQSRGPQGVEDGDRPQPSSKTPKVPKIYTKTGDKGFSSTFTGERRSKDDQVFEAVGTTDELSSAIGFVMELIAEKGHPFVEELQKIQCSLQDVGSALATPRSSAREAHLKHATFEAGPILELEQWIDKYSRQLPPLTAFILPSGGKSSSALHFCRAVCRRAERRVVPLVQTGETDANVVKFLNSQIHSHEGRESRKDIQEK", "length": 226, "header": "tr|A0AAA9TA51-1|A0AAA9TA51_BOVIN Computationally mapped isoform of Corrinoid adenosyltransferase MMAB OS=Bos taurus OX=9913 GN=MMAB PE=3 SV=1 CANONICAL=A0AAA9SMZ5-1" }, "locus": { "chromosome": "17", "start_pos": 63639033, "end_pos": 63628835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128903.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128903.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093756.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093756.1" } ] } }, { "isoform_ac": "A0AAA9TL88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5/entry#A0AAA9TL88-1", "sequence": { "sequence": "MAVWGPGGRLGLRGCLGARKLLCPRFQSRGPQGVEDGDRPQPSSKTPKVPKIYTKTGDKGFSSTFTGERRSKDDQVFEAVGTTDELSSAIGFVMELIAEKGHPFVEELQKIQCSLQDVGSALATPRSSAREAHLKHATFEAGPILELEQWIDKYSRQLPPLTAFILPYSCLENPMDRGAWRAAVHRVTKSRTRLSDNTQRLRPVRRQEQLRTALLSGRVSPSRETALGPKWFVKGRWVTEELQLQEESHLPRAVHVSSAHSSKNVETVQRKV", "length": 272, "header": "tr|A0AAA9TL88-1|A0AAA9TL88_BOVIN Computationally mapped isoform of Metabolism of cobalamin associated B OS=Bos taurus OX=9913 GN=MMAB PE=3 SV=1 CANONICAL=A0AAA9SMZ5-1" }, "locus": { "chromosome": "17", "start_pos": 63637942, "end_pos": 63628835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093969.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093969.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097956.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097956.1" } ] } }, { "isoform_ac": "E1B6Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5/entry#E1B6Z7-1", "sequence": { "sequence": "MAVWGPGGRLGLRGCLGARKLLCPRFQSRGPQGVEDGDRPQPSSKTPKVPKIYTKTGDKGFSSTFTGERRSKDDQVFEAVGTTDELSSAIGFVMELIAEKGHPFVEELQKIQCSLQDVGSALATPRSSAREAHLKHATFEAGPILELEQWIDKYSRQLPPLTAFILPYSCLENPMDRGAWRAAVHRVTKSRTRLSDNTQRLRPVRRQEQLRTALLSGRVSPSRETRGASCPDG", "length": 233, "header": "tr|E1B6Z7-1|E1B6Z7_BOVIN Computationally mapped isoform of Metabolism of cobalamin associated B OS=Bos taurus OX=9913 GN=MMAB PE=3 SV=4 CANONICAL=A0AAA9SMZ5-1" }, "locus": { "chromosome": "17", "start_pos": 63638306, "end_pos": 63628835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006821.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006821.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006821.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006821.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9759218", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9759218", "resource": "Reactome", "description": "Cobalamin (Cbl) metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" } ], "pmid": "" }, { "name": "corrinoid adenosyltransferase activity", "id": "GO:0008817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" } ], "pmid": "" }, { "name": "cobalamin binding", "id": "GO:0031419", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031419", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cobalamin metabolic process", "id": "GO:0009235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "56796", "name": "", "equation": "cob(I)alamin-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)alamin + triphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58D49-1" ], "evidence": [ { "id": "56796", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56796" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q58D49", "gene_name": "MMAB", "activity": [ { "ec_number": "2.5.1.-", "activity": "", "evidence": [ { "id": "Q58D49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D49" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ5" }, { "id": "PF01923", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cobalamin adenosyltransferase-like", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 220, "start_aa": "Gln", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SN70-1", "uniprot_ac": "A0AAA9SN70", "uniprot_id": "A0AAA9SN70_BOVIN", "mass": { "chemical_mass": 35421.0, "monoisotopic_mass": 35421.0 }, "refseq": { "ac": "NP_001377439", "name": "olfactory receptor family 2 subfamily A member 69", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377439" }, "gene_names": [ { "name": "OR2A69", "type": "recommended", "evidence": [ { "id": "A0AAA9SN70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70" } ] }, { "name": "OR2A69", "type": "synonym", "evidence": [ { "id": "NP_001377439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377439" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SN70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2A12", "type": "synonym", "evidence": [ { "id": "NP_001377439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377439" } ] }, { "name": "olfactory receptor family 2 subfamily A member 69", "type": "synonym", "evidence": [ { "id": "NP_001377439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377439" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377439" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2A69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70", "locus": { "chromosome": "4", "start_pos": 107349010, "end_pos": 107300383, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064065", "url": "https://www.ensembl.org/id/ENSBTAG00000064065" } ] } } ], "crossref": [ { "id": "cd15420", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15420", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787740", "url": "https://www.ncbi.nlm.nih.gov/gene/787740", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787740", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787740", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SN70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGNQSWIAEFILLGFQLSEDMELLLFVIFILLYTFNLLANGMILGLISLEPRLHTPMYYFLSHLAITDVAYASSHLPNMLENLVKHKKTISYFSCTMQMVSYLAFASVECLTLVVMSYDRFVAICHPLQYTVIMNWRVCTFLAIACWVCGFSLAIVQVSLFLRLPFCGPQKVNHFFCEISSVLKVTCGDIWINEMFLFADGVFILVGPLSLMLVSYVSILWAILKNQSKEGRKKAFSTCSSHLCVVGFYFSIAMMVYLAPDSSHQEEQKKILFLFYTFFNPLLNPLVYSVRNAQVKAAFHKVLQKNRSV", "length": 310, "header": "tr|A0AAA9SN70-1|A0AAA9SN70_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A69 PE=3 SV=1 CANONICAL=A0AAA9SN70-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70/entry#A0AAA9SN70-1", "sequence": { "sequence": "MKGNQSWIAEFILLGFQLSEDMELLLFVIFILLYTFNLLANGMILGLISLEPRLHTPMYYFLSHLAITDVAYASSHLPNMLENLVKHKKTISYFSCTMQMVSYLAFASVECLTLVVMSYDRFVAICHPLQYTVIMNWRVCTFLAIACWVCGFSLAIVQVSLFLRLPFCGPQKVNHFFCEISSVLKVTCGDIWINEMFLFADGVFILVGPLSLMLVSYVSILWAILKNQSKEGRKKAFSTCSSHLCVVGFYFSIAMMVYLAPDSSHQEEQKKILFLFYTFFNPLLNPLVYSVRNAQVKAAFHKVLQKNRSV", "length": 310, "header": "tr|A0AAA9SN70-1|A0AAA9SN70_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A69 PE=3 SV=1 CANONICAL=A0AAA9SN70-1" }, "locus": { "chromosome": "4", "start_pos": 107347488, "end_pos": 107346559, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125883.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125883.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097747.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097747.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787740", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787740", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SN70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN70" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SN71-1", "uniprot_ac": "A0AAA9SN71", "uniprot_id": "A0AAA9SN71_BOVIN", "mass": { "chemical_mass": 133949.0, "monoisotopic_mass": 133949.0 }, "refseq": { "ac": "XP_024849829", "name": "protocadherin-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849829" }, "gene_names": [ { "name": "PCDH1", "type": "recommended", "evidence": [ { "id": "A0AAA9SN71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ] }, { "name": "PCDH1", "type": "synonym", "evidence": [ { "id": "XP_024849829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849829" } ] } ], "protein_names": [ { "name": "Protocadherin 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SN71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71/entry#names_and_taxonomy" } ] }, { "name": "protocadherin-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024849829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849829" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71", "locus": { "chromosome": "7", "start_pos": 52934572, "end_pos": 52958313, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012518", "url": "https://www.ensembl.org/id/ENSBTAG00000012518" } ] } } ], "crossref": [ { "id": "A0AAA9SN71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SN71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012518", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012518", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509388", "url": "https://www.ncbi.nlm.nih.gov/gene/509388", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M024", "url": "https://www.orthodb.org/?gene=A0A3Q1M024", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6Q0C0", "url": "https://www.orthodb.org/?gene=F6Q0C0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08374", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08374", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024849829", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M024", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M024", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M024-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M024-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q0C0", "url": "https://www.uniprot.org/uniprotkb/F6Q0C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q0C0-1", "url": "https://www.uniprot.org/uniprotkb/F6Q0C0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDCRARGRRCPESALLILEPAPMGPLRHSPGPGERRLLLPTLLLALLLLLAPSPGHATRVVYKVAEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGEPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLPIPENTNIGSLFSIPVASDRDAGPNGVASYELQVGPEAQELFGLQVAEDQEGKQPQLIVMGNLDRERLDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIDYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVVAEVTASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIRVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLTVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPFITAPSNTSHRLLTPQTRLGETVSQVTAEDIDSGVNAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSSKVSKGNKSKGKKSKSPKPVKPVEDEDETGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQELPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENDLRPLPDVAMTGTCTRECSEFGHSDTCWMPGQSSPSRRTKSSALKLSTFVPYQDRGGQEPAGAGSPSPPEDRNTKTAPVRLLPSYSAFSHSSHDSCKDSATLEEIPLTQTSDFPPAATPASAQTAKREIYL", "length": 1237, "header": "tr|A0AAA9SN71-1|A0AAA9SN71_BOVIN Isoform 1 of Protocadherin 1 OS=Bos taurus OX=9913 GN=PCDH1 PE=4 SV=1 CANONICAL=A0AAA9SN71-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M024-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71/entry#A0A3Q1M024-1", "sequence": { "sequence": "MPSQRLWICKAGLVVVWWCWRRGGSQALLILEPAPMGPLRHSPGPGERRLLLPTLLLALLLLLAPSPGHATRVVYKVAEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGEPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLPIPENTNIGSLFSIPVASDRDAGPNGVASYELQVGPEAQELFGLQVAEDQEGKQPQLIVMGNLDRERLDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIDYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVVAEVTASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIRVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLTVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPFITAPSNTSHRLLTPQTRLGETVSQVTAEDIDSGVNAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSSKVSKGNKSKGKKSKSPKPVKPVEDEDETGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQELPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQVGQPLRLSTPQPPPHPYHGAIWTEVWE", "length": 1073, "header": "tr|A0A3Q1M024-1|A0A3Q1M024_BOVIN Computationally mapped isoform of Protocadherin 1 OS=Bos taurus OX=9913 GN=PCDH1 PE=4 SV=2 CANONICAL=A0AAA9SN71-1" }, "locus": { "chromosome": "7", "start_pos": 52950945, "end_pos": 52943531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083691.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083691.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062959.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062959.2" } ] } }, { "isoform_ac": "A0AAA9SN71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71/entry#A0AAA9SN71-1", "sequence": { "sequence": "MDCRARGRRCPESALLILEPAPMGPLRHSPGPGERRLLLPTLLLALLLLLAPSPGHATRVVYKVAEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGEPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLPIPENTNIGSLFSIPVASDRDAGPNGVASYELQVGPEAQELFGLQVAEDQEGKQPQLIVMGNLDRERLDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIDYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVVAEVTASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIRVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLTVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPFITAPSNTSHRLLTPQTRLGETVSQVTAEDIDSGVNAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSSKVSKGNKSKGKKSKSPKPVKPVEDEDETGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQELPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENDLRPLPDVAMTGTCTRECSEFGHSDTCWMPGQSSPSRRTKSSALKLSTFVPYQDRGGQEPAGAGSPSPPEDRNTKTAPVRLLPSYSAFSHSSHDSCKDSATLEEIPLTQTSDFPPAATPASAQTAKREIYL", "length": 1237, "header": "tr|A0AAA9SN71-1|A0AAA9SN71_BOVIN Isoform 1 of Protocadherin 1 OS=Bos taurus OX=9913 GN=PCDH1 PE=4 SV=1 CANONICAL=A0AAA9SN71-1" }, "locus": { "chromosome": "7", "start_pos": 52958197, "end_pos": 52935576, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097401.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097401.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084280.1" } ] } }, { "isoform_ac": "A0AAA9SXR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71/entry#A0AAA9SXR8-1", "sequence": { "sequence": "MDCRARGRRCPESALLILEPAPMGPLRHSPGPGERRLLLPTLLLALLLLLAPSPGHATRVVYKVAEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGEPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLPIPENTNIGSLFSIPVASDRDAGPNGVASYELQVGPEAQELFGLQVAEDQEGKQPQLIVMGNLDRERLDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENEPAGRSRP", "length": 382, "header": "tr|A0AAA9SXR8-1|A0AAA9SXR8_BOVIN Computationally mapped isoform of Protocadherin 1 OS=Bos taurus OX=9913 GN=PCDH1 PE=4 SV=1 CANONICAL=A0AAA9SN71-1" }, "locus": { "chromosome": "7", "start_pos": 52958197, "end_pos": 52937113, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126449.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126449.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088862.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088862.1" } ] } }, { "isoform_ac": "A0AAA9SY53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71/entry#A0AAA9SY53-1", "sequence": { "sequence": "MIETLLILEPAPMGPLRHSPGPGERRLLLPTLLLALLLLLAPSPGHATRVVYKVAEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGEPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLPIPENTNIGSLFSIPVASDRDAGPNGVASYELQVGPEAQELFGLQVAEDQEGKQPQLIVMGNLDRERLDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIDYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVVAEVTASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIRVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLTVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPFITAPSNTSHRLLTPQTRLGETVSQVTAEDIDSGVNAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSSKVSKGNKSKGKKSKSPKPVKPVEDEDETGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQELPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQVGQPLRLSTPQPPPHPYHGAIWTEVWE", "length": 1050, "header": "tr|A0AAA9SY53-1|A0AAA9SY53_BOVIN Computationally mapped isoform of Protocadherin 1 OS=Bos taurus OX=9913 GN=PCDH1 PE=4 SV=1 CANONICAL=A0AAA9SN71-1" }, "locus": { "chromosome": "7", "start_pos": 52956488, "end_pos": 52943531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103041.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103041.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091398.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091398.1" } ] } }, { "isoform_ac": "F6Q0C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71/entry#F6Q0C0-1", "sequence": { "sequence": "MDCRARGRRCPESALLILEPAPMGPLRHSPGPGERRLLLPTLLLALLLLLAPSPGHATRVVYKVAEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGEPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLPIPENTNIGSLFSIPVASDRDAGPNGVASYELQVGPEAQELFGLQVAEDQEGKQPQLIVMGNLDRERLDSYDLTIKVQDGGNPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIDYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVVAEVTASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIRVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENARVQLTVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPFITAPSNTSHRLLTPQTRLGETVSQVTAEDIDSGVNAELTYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGNILFGVVAGVVAVALLIALAVLVRYCRQREAKSGYQAGKKETKDLYAPKPSSKVSKGNKSKGKKSKSPKPVKPVEDEDETGLQKSLKFNLMSDAPGDSPRIHLPLNYPPGSPDLGRHYRSNSPLPSIQLQPQSPSASKKHQVVQELPPANTFVGTGDTTSTGSEQYSDYSYRTNPPKYPSKQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENEPAGRSRP", "length": 1114, "header": "tr|F6Q0C0-1|F6Q0C0_BOVIN Computationally mapped isoform of Protocadherin 1 OS=Bos taurus OX=9913 GN=PCDH1 PE=4 SV=4 CANONICAL=A0AAA9SN71-1" }, "locus": { "chromosome": "7", "start_pos": 52958197, "end_pos": 52937113, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016618.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016618.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016618.8", "url": "https://www.ensembl.org/id/ENSBTAP00000016618.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1224, "start_aa": "Thr", "end_pos": 1224, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1224", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SN71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 618, "end_pos": 620, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 720, "end_pos": 722, "annotation": "n_glycosylation_sequon" }, { "start_pos": 813, "end_pos": 815, "annotation": "n_glycosylation_sequon" }, { "start_pos": 818, "end_pos": 820, "annotation": "n_glycosylation_sequon" }, { "start_pos": 909, "end_pos": 911, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SN71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN71" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 168, "start_aa": "His", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1224 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 618, "end_pos": 620 }, { "start_pos": 662, "end_pos": 664 }, { "start_pos": 720, "end_pos": 722 }, { "start_pos": 813, "end_pos": 815 }, { "start_pos": 818, "end_pos": 820 }, { "start_pos": 909, "end_pos": 911 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNA3-1", "uniprot_ac": "A0AAA9SNA3", "uniprot_id": "A0AAA9SNA3_BOVIN", "mass": { "chemical_mass": 11106.0, "monoisotopic_mass": 11106.0 }, "refseq": {}, "gene_names": [ { "name": "SLURP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ] } ], "protein_names": [ { "name": "Secreted LY6/PLAUR domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLURP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3", "locus": { "chromosome": "14", "start_pos": 1691977, "end_pos": 1689760, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016209", "url": "https://www.ensembl.org/id/ENSBTAG00000016209" } ] } } ], "crossref": [ { "id": "A0AAA9SNA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016209", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016209", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618706", "url": "https://www.ncbi.nlm.nih.gov/gene/618706", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR035076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618706", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618706", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PKSCCYT", "url": "https://omabrowser.org/oma/group/PKSCCYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP47", "url": "https://www.orthodb.org/?gene=E1BP47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16983:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16983:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP47", "url": "https://www.uniprot.org/uniprotkb/E1BP47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP47-1", "url": "https://www.uniprot.org/uniprotkb/E1BP47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVPRALLALLLAAASAVHLGEALSCITCEQPTALPLCKNITYCKPNEIACKTTLVTVEAEFPFNESPVVTSTCASSCEATDPDSIGAAHPIFCCFHDLCNSECW", "length": 105, "header": "tr|A0AAA9SNA3-1|A0AAA9SNA3_BOVIN Isoform 1 of Secreted LY6/PLAUR domain containing 1 OS=Bos taurus OX=9913 GN=SLURP1 PE=4 SV=1 CANONICAL=A0AAA9SNA3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3/entry#A0AAA9SNA3-1", "sequence": { "sequence": "MAVPRALLALLLAAASAVHLGEALSCITCEQPTALPLCKNITYCKPNEIACKTTLVTVEAEFPFNESPVVTSTCASSCEATDPDSIGAAHPIFCCFHDLCNSECW", "length": 105, "header": "tr|A0AAA9SNA3-1|A0AAA9SNA3_BOVIN Isoform 1 of Secreted LY6/PLAUR domain containing 1 OS=Bos taurus OX=9913 GN=SLURP1 PE=4 SV=1 CANONICAL=A0AAA9SNA3-1" }, "locus": { "chromosome": "14", "start_pos": 1690927, "end_pos": 1689959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090658.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090658.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085373.1" } ] } }, { "isoform_ac": "A0AAA9SVE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3/entry#A0AAA9SVE0-1", "sequence": { "sequence": "MAVPRALLALLLAAASAVHLGEALSCITCEQPTALPLCKNITYCKPNEIACKTTLVTVEAEFPFNESPVVTSTCASSCEATDPDSIGAAHPIFCCFHDLCNSVGIARLSAGALAPLGAVVLSHLLP", "length": 126, "header": "tr|A0AAA9SVE0-1|A0AAA9SVE0_BOVIN Computationally mapped isoform of Secreted LY6/PLAUR domain containing 1 OS=Bos taurus OX=9913 GN=SLURP1 PE=4 SV=1 CANONICAL=A0AAA9SNA3-1" }, "locus": { "chromosome": "14", "start_pos": 1690973, "end_pos": 1689959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104368.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104368.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090436.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090436.1" } ] } }, { "isoform_ac": "E1BP47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3/entry#E1BP47-1", "sequence": { "sequence": "MVLSPAPPRAGVTPCSPGEALSCITCEQPTALPLCKNITYCKPNEIACKTTLVTVEAEFPFNESPVVTSTCASSCEATDPDSIGAAHPIFCCFHDLCNSVGIARLSAGALAPLGAVVLSHLLP", "length": 123, "header": "tr|E1BP47-1|A0AAA9SNA3_BOVIN Computationally mapped isoform of Secreted LY6/PLAUR domain containing 1 OS=Bos taurus OX=9913 GN=SLURP1 PE=4 SV=4 CANONICAL=A0AAA9SNA3-1" }, "locus": { "chromosome": "14", "start_pos": 1690973, "end_pos": 1690128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048865.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048865.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045831.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045831.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618706", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618706", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A7L8-1", "protein_name": "Secreted Ly6/Plaur domain containing 1", "gene_name": "Slurp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLRWAVWLLLLAAWSMGYGEAFRCYTCEQPTAINSCKNIVHCKLEDTACKTVLETVEAEFPFNHSPMVTRSCSSSCLATDPDGIGVAHPVFCCFRDLCNSGFPGLVTGL", "length": 110 }, "evidence": [ { "id": "A0AAA9SNA3", "url": "https://omabrowser.org/oma/group/A0AAA9SNA3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I917-1", "protein_name": "Secreted Ly-6/uPAR-related protein 1", "gene_name": "Slurp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAFRWAMWLLLLAAWNMGSGEAFRCYTCEQPTAINACKNIAQCKLEDTACKTVLETVEAEFPFNHSPMVTRSCSSSCLATDPDGIGVAHPVYCCFRDLCNSGDPGLVTGL", "length": 110 }, "evidence": [ { "id": "A0AAA9SNA3", "url": "https://omabrowser.org/oma/group/A0AAA9SNA3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P55000-1", "protein_name": "Secreted Ly-6/uPAR-related protein 1", "gene_name": "SLURP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSEL", "length": 103 }, "evidence": [ { "id": "A0AAA9SNA3", "url": "https://omabrowser.org/oma/group/A0AAA9SNA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0K7-1", "protein_name": "Secreted Ly-6/uPAR-related protein 1", "gene_name": "Slurp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLRWAMWLLLLAAWSMGYGEAFRCYTCEQPTAINSCKNIAQCKMEDTACKTVLETVEAAFPFNHSPMVTRSCSSSCLATDPDGIGVAHPVFCCFRDLCNSGFPGFVAGL", "length": 110 }, "evidence": [ { "id": "A0AAA9SNA3", "url": "https://omabrowser.org/oma/group/A0AAA9SNA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "urokinase plasminogen activator signaling pathway", "id": "GO:0038195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038195", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "acetylcholine receptor activator activity", "id": "GO:0030549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030549", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNA3" }, { "id": "PF00087", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00087" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Snake toxin/toxin-like", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 101, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 40, "end_pos": 42 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNB3-1", "uniprot_ac": "A0AAA9SNB3", "uniprot_id": "A0AAA9SNB3_BOVIN", "mass": { "chemical_mass": 8161.0, "monoisotopic_mass": 8161.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SNB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SNB3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SNB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTAVPVFAILFSMSHVPPDRASFKEVCEHPNRSCQEFCLNSEIHFGRLDCRQCSLPMVNIPQVDCTTPRVH", "length": 72, "header": "tr|A0AAA9SNB3-1|A0AAA9SNB3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SNB3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB3/entry#A0AAA9SNB3-1", "sequence": { "sequence": "MSTAVPVFAILFSMSHVPPDRASFKEVCEHPNRSCQEFCLNSEIHFGRLDCRQCSLPMVNIPQVDCTTPRVH", "length": 72, "header": "tr|A0AAA9SNB3-1|A0AAA9SNB3_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SNB3-1" }, "locus": { "chromosome": "27", "start_pos": 6175780, "end_pos": 6172625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088293.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088293.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085383.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNF8-1", "uniprot_ac": "A0AAA9SNF8", "uniprot_id": "A0AAA9SNF8_BOVIN", "mass": { "chemical_mass": 35115.0, "monoisotopic_mass": 35115.0 }, "refseq": {}, "gene_names": [ { "name": "OR8G47", "type": "recommended", "evidence": [ { "id": "A0AAA9SNF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SNF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8G47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SNF8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNF8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "KMDPGNHSLVTEFILAGLTEHPRLQLPLFLLFLGIYVVTVVGNLGMIILIGLSSHLHTPMYYFLSSLSFIDLCQSTVITPRMLVNFVTEKNVISYPECITQLYFFLLFAISECYMLAAMAYDRYVAICSPLLYNIIISHQACFSLIWGVYMMGLICAFSHTGCTLRVHFCKLDMINHYFCDLLSLLKLSCSSTYVNELLVLCFSALNIFAPSLIIVSSYVFIISSVLHIPSMRGRSKAFSTCSSHISAVAIFYGSAAFMYLQPSSVSSMDEGKVSSVFYTIVVPMLNPLIYSLRNRDVNVALKKILERRIFF", "length": 312, "header": "tr|A0AAA9SNF8-1|A0AAA9SNF8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G47 PE=3 SV=1 CANONICAL=A0AAA9SNF8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8/entry#A0AAA9SNF8-1", "sequence": { "sequence": "KMDPGNHSLVTEFILAGLTEHPRLQLPLFLLFLGIYVVTVVGNLGMIILIGLSSHLHTPMYYFLSSLSFIDLCQSTVITPRMLVNFVTEKNVISYPECITQLYFFLLFAISECYMLAAMAYDRYVAICSPLLYNIIISHQACFSLIWGVYMMGLICAFSHTGCTLRVHFCKLDMINHYFCDLLSLLKLSCSSTYVNELLVLCFSALNIFAPSLIIVSSYVFIISSVLHIPSMRGRSKAFSTCSSHISAVAIFYGSAAFMYLQPSSVSSMDEGKVSSVFYTIVVPMLNPLIYSLRNRDVNVALKKILERRIFF", "length": 312, "header": "tr|A0AAA9SNF8-1|A0AAA9SNF8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G47 PE=3 SV=1 CANONICAL=A0AAA9SNF8-1" }, "locus": { "chromosome": "29", "start_pos": 27538204, "end_pos": 27537269, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099687.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099687.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084387.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084387.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 291, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNH2-1", "uniprot_ac": "A0AAA9SNH2", "uniprot_id": "A0AAA9SNH2_BOVIN", "mass": { "chemical_mass": 85458.0, "monoisotopic_mass": 85458.0 }, "refseq": {}, "gene_names": [ { "name": "DLG4", "type": "recommended", "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ] } ], "protein_names": [ { "name": "Disks large homolog 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#names_and_taxonomy" } ] }, { "name": "Postsynaptic density protein 95", "type": "synonym", "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#names_and_taxonomy" } ] }, { "name": "Synapse-associated protein 90", "type": "synonym", "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DLG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2", "locus": { "chromosome": "19", "start_pos": 26909898, "end_pos": 26933650, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002564", "url": "https://www.ensembl.org/id/ENSBTAG00000002564" } ] } } ], "crossref": [ { "id": "A0AAA9SNH2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002564", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002564", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06723", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06723", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06724", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06724", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06795", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06795", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100137840", "url": "https://www.ncbi.nlm.nih.gov/gene/100137840", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MM66", "url": "https://www.orthodb.org/?gene=F1MM66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-399719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-399719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-438066", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-438066", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-451308", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-451308", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5625900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5625900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5682910", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682910", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6794361", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6794361", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8849932", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849932", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T131", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T131", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T131-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T131-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM66", "url": "https://www.uniprot.org/uniprotkb/F1MM66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM66-1", "url": "https://www.uniprot.org/uniprotkb/F1MM66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEGPGPRAPKSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASISESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL", "length": 769, "header": "tr|A0AAA9SNH2-1|A0AAA9SNH2_BOVIN Isoform 1 of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=1 CANONICAL=A0AAA9SNH2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#A0AAA9SNH2-1", "sequence": { "sequence": "MSEGPGPRAPKSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASISESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL", "length": 769, "header": "tr|A0AAA9SNH2-1|A0AAA9SNH2_BOVIN Isoform 1 of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=1 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26933650, "end_pos": 26910012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111006.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111006.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085516.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085516.1" } ] } }, { "isoform_ac": "A0AAA9SSA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#A0AAA9SSA2-1", "sequence": { "sequence": "MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQVGATARPPPPSPHGLPQLSNSLSLSVSLPAGSPLHLLLLLGNSV", "length": 663, "header": "tr|A0AAA9SSA2-1|A0AAA9SSA2_BOVIN Computationally mapped isoform of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=1 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26931965, "end_pos": 26911932, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106440.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106440.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088214.1" } ] } }, { "isoform_ac": "A0AAA9SWD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#A0AAA9SWD0-1", "sequence": { "sequence": "MLSLSSSHALSFFLSPIPSSGSGQDESSAWANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL", "length": 719, "header": "tr|A0AAA9SWD0-1|A0AAA9SWD0_BOVIN Computationally mapped isoform of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=1 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26923591, "end_pos": 26910012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112658.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112658.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090780.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090780.1" } ] } }, { "isoform_ac": "A0AAA9T131-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#A0AAA9T131-1", "sequence": { "sequence": "MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVL", "length": 656, "header": "tr|A0AAA9T131-1|A0AAA9T131_BOVIN Computationally mapped isoform of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=1 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26931965, "end_pos": 26911066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099272.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099272.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091409.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091409.1" } ] } }, { "isoform_ac": "A0AAA9TKS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#A0AAA9TKS0-1", "sequence": { "sequence": "MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTCESPPNPGAPHAPHQSPHDPLTLPLQILPLNW", "length": 291, "header": "tr|A0AAA9TKS0-1|A0AAA9TKS0_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 4 OS=Bos taurus OX=9913 GN=DLG4 PE=4 SV=1 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26931965, "end_pos": 26919412, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134110.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134110.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097547.1" } ] } }, { "isoform_ac": "A0AAA9U1G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#A0AAA9U1G4-1", "sequence": { "sequence": "MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQVNAPELVHVAERNLSHLEAVQGVVGHAHFSPIKANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL", "length": 754, "header": "tr|A0AAA9U1G4-1|A0AAA9U1G4_BOVIN Computationally mapped isoform of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=1 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26931965, "end_pos": 26910012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131638.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131638.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103051.1" } ] } }, { "isoform_ac": "F1MM66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2/entry#F1MM66-1", "sequence": { "sequence": "GRNEVYQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKLMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDVPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL", "length": 696, "header": "tr|F1MM66-1|F1MM66_BOVIN Computationally mapped isoform of Disks large homolog 4 OS=Bos taurus OX=9913 GN=DLG4 PE=3 SV=3 CANONICAL=A0AAA9SNH2-1" }, "locus": { "chromosome": "19", "start_pos": 26923229, "end_pos": 26910012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003326.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003326.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003326.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003326.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-399719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-399719", "resource": "Reactome", "description": "Trafficking of AMPA receptors" }, { "id": "R-BTA-438066", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-438066", "resource": "Reactome", "description": "Unblocking of NMDA receptors, glutamate binding and activation" }, { "id": "R-BTA-451308", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-451308", "resource": "Reactome", "description": "Activation of Ca-permeable Kainate Receptor" }, { "id": "R-BTA-5625900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5625900", "resource": "Reactome", "description": "RHO GTPases activate CIT" }, { "id": "R-BTA-5673001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "resource": "Reactome", "description": "RAF/MAP kinase cascade" }, { "id": "R-BTA-5682910", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682910", "resource": "Reactome", "description": "LGI-ADAM interactions" }, { "id": "R-BTA-6794361", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6794361", "resource": "Reactome", "description": "Neurexins and neuroligins" }, { "id": "R-BTA-8849932", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849932", "resource": "Reactome", "description": "Synaptic adhesion-like molecules" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 18, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "AMPA glutamate receptor complex", "id": "GO:0032281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "cortical cytoskeleton", "id": "GO:0030863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030863", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "cerebellar mossy fiber", "id": "GO:0044300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "neuron projection terminus", "id": "GO:0044306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044306", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "excitatory synapse", "id": "GO:0060076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "juxtaparanode region of axon", "id": "GO:0044224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "neuromuscular process controlling balance", "id": "GO:0050885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "establishment of protein localization", "id": "GO:0045184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "social behavior", "id": "GO:0035176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "dendritic spine morphogenesis", "id": "GO:0060997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060997", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "locomotory exploration behavior", "id": "GO:0035641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035641", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "cellular response to potassium ion", "id": "GO:0035865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "vocalization behavior", "id": "GO:0071625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "positive regulation of synaptic transmission", "id": "GO:0050806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050806", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "regulation of grooming behavior", "id": "GO:2000821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000821", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0099645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099645", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "protein localization to synapse", "id": "GO:0035418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035418", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "AMPA glutamate receptor clustering", "id": "GO:0097113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097113", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "receptor localization to synapse", "id": "GO:0097120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097120", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "regulation of postsynaptic membrane neurotransmitter receptor levels", "id": "GO:0099072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099072", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "scaffold protein binding", "id": "GO:0097110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "ionotropic glutamate receptor binding", "id": "GO:0035255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 579, "end_pos": 754, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 110, "end_pos": 197, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNH2" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 473, "end_pos": 543, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 414, "end_pos": 416 }, { "start_pos": 458, "end_pos": 460 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNK8-1", "uniprot_ac": "A0AAA9SNK8", "uniprot_id": "A0AAA9SNK8_BOVIN", "mass": { "chemical_mass": 26503.0, "monoisotopic_mass": 26503.0 }, "refseq": {}, "gene_names": [ { "name": "TM4SF1", "type": "recommended", "evidence": [ { "id": "A0AAA9SNK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8" } ] } ], "protein_names": [ { "name": "Transmembrane 4 L six family member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SNK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM4SF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8", "locus": { "chromosome": "1", "start_pos": 118837474, "end_pos": 118791330, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015163", "url": "https://www.ensembl.org/id/ENSBTAG00000015163" } ] } } ], "crossref": [ { "id": "A0AAA9SNK8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR008661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14198:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14198:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QW52", "url": "https://www.uniprot.org/uniprotkb/F6QW52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QW52-1", "url": "https://www.uniprot.org/uniprotkb/F6QW52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVRPRRFPGSMRRRGTLSSDQGHHRAKPRSKGSGDINSTTMCYGRCARCIGHSLVWLATLCIVANILLYFPNGETKYASDNHLSRFVWFFSGILGGGLLMFLPAFIFIGLDQEDCCGCCGHENCGKRCAMLSSILAALIGIGGSGYCVTVAALALEEGPRCMDASGQWNYTFANTEGDYLLDSSTWSQCVEPKHIVEWNVSLFSILLALGGIEFILCLIQVINGMLGGICGHCSSRQQQYDC", "length": 243, "header": "tr|A0AAA9SNK8-1|A0AAA9SNK8_BOVIN Isoform 1 of Transmembrane 4 L six family member 1 OS=Bos taurus OX=9913 GN=TM4SF1 PE=3 SV=1 CANONICAL=A0AAA9SNK8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8/entry#A0AAA9SNK8-1", "sequence": { "sequence": "MSVRPRRFPGSMRRRGTLSSDQGHHRAKPRSKGSGDINSTTMCYGRCARCIGHSLVWLATLCIVANILLYFPNGETKYASDNHLSRFVWFFSGILGGGLLMFLPAFIFIGLDQEDCCGCCGHENCGKRCAMLSSILAALIGIGGSGYCVTVAALALEEGPRCMDASGQWNYTFANTEGDYLLDSSTWSQCVEPKHIVEWNVSLFSILLALGGIEFILCLIQVINGMLGGICGHCSSRQQQYDC", "length": 243, "header": "tr|A0AAA9SNK8-1|A0AAA9SNK8_BOVIN Isoform 1 of Transmembrane 4 L six family member 1 OS=Bos taurus OX=9913 GN=TM4SF1 PE=3 SV=1 CANONICAL=A0AAA9SNK8-1" }, "locus": { "chromosome": "1", "start_pos": 118817127, "end_pos": 118800926, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113254.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113254.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084443.1" } ] } }, { "isoform_ac": "A0AAA9SZS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8/entry#A0AAA9SZS8-1", "sequence": { "sequence": "MCYGRCARCIGHSLVWLATLCIVANILLYFPNGETKYASDNHLSRFVWFFSGILGGGLLMFLPAFIFIGLDQEDCCGCCGHENCGKRCAMLSSILAALIGIGGSGYCVTVAALALEEGPRCMDASGQWNYTFANTEGDYLLDSSTWSQCVEPKHIVEWNVSLFSILLALGGIEFILCLIQVINGMLGGICGHCSSRQQVLLES", "length": 203, "header": "tr|A0AAA9SZS8-1|A0AAA9SZS8_BOVIN Computationally mapped isoform of Transmembrane 4 L six family member 1 OS=Bos taurus OX=9913 GN=TM4SF1 PE=3 SV=1 CANONICAL=A0AAA9SNK8-1" }, "locus": { "chromosome": "1", "start_pos": 118837405, "end_pos": 118809590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094554.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094554.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091982.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091982.1" } ] } }, { "isoform_ac": "F6QW52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8/entry#F6QW52-1", "sequence": { "sequence": "MALYGILFRGLRGTLSSDQGHHRAKPRSKGSGDINSTTMCYGRCARCIGHSLVWLATLCIVANILLYFPNGETKYASDNHLSRFVWFFSGILGGGLLMFLPAFIFIGLDQEDCCGCCGHENCGKRCAMLSSILAALIGIGGSGYCVTVAALALEEGPRCMDASGQWNYTFANTEGDYLLDSSTWSQCVEPKHIVEWNVSLFSILLALGGIEFILCLIQVINGMLGGICGHCSSRQQQYDC", "length": 240, "header": "tr|F6QW52-1|F6QW52_BOVIN Computationally mapped isoform of Transmembrane 4 L six family member 1 OS=Bos taurus OX=9913 GN=TM4SF1 PE=3 SV=1 CANONICAL=A0AAA9SNK8-1" }, "locus": { "chromosome": "1", "start_pos": 118817127, "end_pos": 118791386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020168.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020168.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020168.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020168.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 150, "start_aa": "Thr", "end_pos": 150, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr150", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 150 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNL2-1", "uniprot_ac": "A0AAA9SNL2", "uniprot_id": "A0AAA9SNL2_BOVIN", "mass": { "chemical_mass": 96369.0, "monoisotopic_mass": 96369.0 }, "refseq": { "ac": "XP_005213882", "name": "M-phase phosphoprotein 8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213882" }, "gene_names": [ { "name": "MPHOSPH8", "type": "recommended", "evidence": [ { "id": "A0AAA9SNL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ] }, { "name": "MPHOSPH8", "type": "synonym", "evidence": [ { "id": "XP_005213882", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213882" } ] } ], "protein_names": [ { "name": "M-phase phosphoprotein 8", "type": "recommended", "evidence": [ { "id": "A0AAA9SNL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2/entry#names_and_taxonomy" } ] }, { "name": "M-phase phosphoprotein 8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005213882", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213882" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPHOSPH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2", "locus": { "chromosome": "12", "start_pos": 36349338, "end_pos": 36395274, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003922", "url": "https://www.ensembl.org/id/ENSBTAG00000003922" } ] } } ], "crossref": [ { "id": "A0AAA9SNL2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18633", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18633", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507091", "url": "https://www.ncbi.nlm.nih.gov/gene/507091", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PNRACHP", "url": "https://omabrowser.org/oma/group/PNRACHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQK9", "url": "https://www.orthodb.org/?gene=F1MQK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24166:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24166:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00385", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00385", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9764725", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9764725", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9843970", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843970", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005213882", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213882", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQK9", "url": "https://www.uniprot.org/uniprotkb/F1MQK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQK9-1", "url": "https://www.uniprot.org/uniprotkb/F1MQK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAKAEAEGASVATVPGSGADGSGQLPAVEGEGFGARGKEKDAAAKGKEAGGDSEEDGENVFEVEKILDMKTEGGKVLYKVRWKGYTADDDTWEPEIHLEDCKEVLLEFRKKIADNKAKSVKKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKVRHKEEKSPDDLKKKKAKTGKLKDKPKPDLESSSESLGFDLRTKKRILEAKEELKESKKPKKDDIKETKELKKVKKGEIRDLKTKIRDDSKEIRKTKKEKCVESQVDSDLGVLSDSPLQEEDCEDLQVDNREEKQKFRGAKDKAEQEASLDPASDIQQDGSVSADEDEVKARRKKKKPRRTEELKESKKLENKSLFLEKKTTQKKQRNQDKGQSSTELDKPVPASALTPPRMSRPTDSPGEERETKKYEPKEKYQKKQDLDKEEKGRKEPKALKIAFKEIRNAFDLFKLTPEEKNDFPENNRKRDEIPPDYKVTEDHKAKENKPLLKERRNTRDETDTWAYIAAEGDQEVLDSAIRVEESPDGKQQVLSLGMDLQLEWMRLEDFQKHLDGEDENVTTADVIPSNLLRDAVKNGDYITVKVALNSSEEYNLDQEDSSGMTLLMLAAAGGQDDLLRLLLRKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQNNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQCNNVLVYDLLKSHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSMDFNYRPPQTIPEGSGVLLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGLNKMFIRLTEAPSAKVKLLIGAYRVQLQ", "length": 856, "header": "tr|A0AAA9SNL2-1|A0AAA9SNL2_BOVIN Isoform 1 of M-phase phosphoprotein 8 OS=Bos taurus OX=9913 GN=MPHOSPH8 PE=4 SV=1 CANONICAL=A0AAA9SNL2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2/entry#A0AAA9SNL2-1", "sequence": { "sequence": "MAEAKAEAEGASVATVPGSGADGSGQLPAVEGEGFGARGKEKDAAAKGKEAGGDSEEDGENVFEVEKILDMKTEGGKVLYKVRWKGYTADDDTWEPEIHLEDCKEVLLEFRKKIADNKAKSVKKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKVRHKEEKSPDDLKKKKAKTGKLKDKPKPDLESSSESLGFDLRTKKRILEAKEELKESKKPKKDDIKETKELKKVKKGEIRDLKTKIRDDSKEIRKTKKEKCVESQVDSDLGVLSDSPLQEEDCEDLQVDNREEKQKFRGAKDKAEQEASLDPASDIQQDGSVSADEDEVKARRKKKKPRRTEELKESKKLENKSLFLEKKTTQKKQRNQDKGQSSTELDKPVPASALTPPRMSRPTDSPGEERETKKYEPKEKYQKKQDLDKEEKGRKEPKALKIAFKEIRNAFDLFKLTPEEKNDFPENNRKRDEIPPDYKVTEDHKAKENKPLLKERRNTRDETDTWAYIAAEGDQEVLDSAIRVEESPDGKQQVLSLGMDLQLEWMRLEDFQKHLDGEDENVTTADVIPSNLLRDAVKNGDYITVKVALNSSEEYNLDQEDSSGMTLLMLAAAGGQDDLLRLLLRKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQNNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQCNNVLVYDLLKSHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSMDFNYRPPQTIPEGSGVLLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGLNKMFIRLTEAPSAKVKLLIGAYRVQLQ", "length": 856, "header": "tr|A0AAA9SNL2-1|A0AAA9SNL2_BOVIN Isoform 1 of M-phase phosphoprotein 8 OS=Bos taurus OX=9913 GN=MPHOSPH8 PE=4 SV=1 CANONICAL=A0AAA9SNL2-1" }, "locus": { "chromosome": "12", "start_pos": 36395075, "end_pos": 36350342, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125475.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125475.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085547.1" } ] } }, { "isoform_ac": "F1MQK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2/entry#F1MQK9-1", "sequence": { "sequence": "MAEAKAEAEGASVATVPGSGADGSGQLPAVEGEGFGARGKEKDAAAKGKEAGGDSEEDGENVFEVEKILDMKTEGGKVLYKVRWKGYTADDDTWEPEIHLEDCKEVLLEFRKKIADNKAKSVKKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKVRHKEEKSPDDLKKKKAKTGKLKDKPKPDLESSSESLGFDLRTKKRILEAKEELKESKKPKKDDIKETKELKKVKKGEIRDLKTKIRDDSKEIRKTKKEKCVESQVDSDLGVLSDSPLQEEDCEDLQVDNREEKQKFRGAKDKAEQEASLDPASDIQQDGSVSADEDEVKARRKKKKPRRTEELKESKKLENKSLFLEKKTTQKKQRNQDKGQSSTELDKPVPASALTPPRMSRPTDSPGEERETKKYEPKEKYQKKQDLDKEEKGRKEPKALKTFKEIRNAFDLFKLTPEEKNDFPENNRKRDEIPPDYKVTEDHKAKENKPLLKERRNTRDETDTWAYIAAEGDQEVLDSAIRVEESPDGKQQVLSLGMDLQLEWMRLEDFQKHLDGEDENVTTADVIPSNLLRDAVKNGDYITVKVALNSSEEYNLDQEDSSGMTLLMLAAAGGQDDLLRLLLRKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQNNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQCNNVLVYDLLKSHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSMDFNYRPPQTIPEATWQVRPWPPLGHGCRIYGMETALSWPERWELGWVLAFVLFVLVQLLSRVPTLQLCNATLCPPLSPRVCSNSSPWSQ", "length": 848, "header": "tr|F1MQK9-1|F1MQK9_BOVIN Computationally mapped isoform of M-phase phosphoprotein 8 OS=Bos taurus OX=9913 GN=MPHOSPH8 PE=4 SV=4 CANONICAL=A0AAA9SNL2-1" }, "locus": { "chromosome": "12", "start_pos": 36395075, "end_pos": 36352632, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061268.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061268.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053300.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053300.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9764725", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9764725", "resource": "Reactome", "description": "Negative Regulation of CDH1 Gene Transcription" }, { "id": "R-BTA-9843970", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843970", "resource": "Reactome", "description": "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QBY1-1", "protein_name": "M-phase phosphoprotein 8", "gene_name": "Mphosph8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAAAAEESMSMAALAMSVPDSTVGSPRAEGEGVGVAREEKDATTKGTEAFGDSEEDGDDVFEVEKILDMKCEGGKNLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKVAENKAKAIKKDIQRLSLSNDIFEADFDSDQQSDTKEDTSPRKKKKKIKCKEEKSPDDLKKKKAKLGKLKDKFKSELESTSENLGFDIRTKKRILEAKEELKDSKKLKKDEIKENKELKKAKRAEIRDLKFKIREDIKDNRKTKKERSIECPLEFESPVPNESLSPEDDGEDFVSDNKEEKQKIRTVKDKAGQDTVQEGIFEKHLDDLVSTDEDAGARVRRKKKKPRIFDETKEIKKLENMDTFLERKMIPKKQRYQDKSRNNLELSRLPSPMSIQAPKSSRLSGEEKGLRSSDSAEEEKDTKKNESKEKYQKKYDLDKEEKCRKEPKGLKSFKEIRSAFDLFKKTEDKNDVLENNWKREEVPLDCKTTDDPKNKDKCSLKDRRNTRDETDTWAYIAAEGDQEVSDSVCQTDENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGEDETFTTTNTIPSNLLRDAVKNGDYIAVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGVLLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKVKLLIGAYRVQLH", "length": 863 }, "evidence": [ { "id": "A0AAA9SNL2", "url": "https://omabrowser.org/oma/group/A0AAA9SNL2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B0S768-1", "protein_name": "2.4.2.30", "gene_name": "mphosph8", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASGAERAEPGDSEQDEEDVYEVERIIDVRVEEGEVLYRVRWKNYSSEDDTWEPEAHLDDCKEVLLAYKKALAELKPKKEPAMLPMKSDLFDADSESDSDKEKPKESPMKKKKKKKKKKIEDSDDEMSVREKKKKKKKEKWREDKPLPAPESDEEESRDPSPAPSKKETKKRFIDSDDEDVPVTPKKQKKLDKPKDAGKVKKESGEERKKKKIKSKREIDSSDEDEKSDAPSESHTDDTTNTETNDSFKTTTKITEKPVRSESGGDLKQVKQKKDKSDIKLQGFKDLILEKKPKKPEASSAAAKDVGLNKIKSLTGSKSTSKSSRSEEEPDSSDTGAAASAPKAKVKSKSQEAAPSSQRLSSASSSSSSSTASTAPIKPREDEAKEEAGDKASASNLFEKFLLNCEAKDRAPRRQVDQNKSATPKGGSKNDKKTKPSKQSPGRKPDSDKTKDVPRSSQSPISMEVDEKQEKGSSELEKSEKSDEPNFKSKEELQREQREEEQRKRKEKMEEEERKRKERIEEEERKKKERIEEAQRERKARLEEAQRFAEEARQELERKSMAESIVSPDSTEDSRWKDKRRKRRDDSESRVFTTCDDNQDSQETVERSDKTPDRGPPSLNLGVELKLDWMTLEDFQKHLNGEDENLSPLALTPTELREAVKNGNYLAVKRALSSKEDYNLDQEDSSGMSLTLLAAAGGQDDILRLLIKKGVKVNSRQKTGTTALMHAADKNFLTTVAILLEAGAFVNAQTLGGETALMKACKRGNADVVRLLLEYGADCNILSKHKNTALYYAKLSNNLMVYDLIKDHMQTLSTVAEETIRAYFETRLALLEPVFPLACHRLCEGPDFSLEFNYKPPQHAPGEGSGILLFIFHANFLNEITARLCGPCSVHAVVLNDKFQLPIFLDSHFIYSFSPVQGANKMFIRLAESPTAKVKLLICAYRVQLQ", "length": 946 }, "evidence": [ { "id": "A0AAA9SNL2", "url": "https://omabrowser.org/oma/group/A0AAA9SNL2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1P0K0-1", "protein_name": "M-phase phosphoprotein 8", "gene_name": "MPHOSPH8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAGSGAEAAAARLEGAGEEEETAAAGDGENEVVDGGGAGGAAGAAAAGGESEEEEDVFEVEKILDVKTEGGVILYKVRWKGYTSDDDTWEPEVHLEDCKEVLLEFRKKLVDTKPKPAKKDLQKLSLNDDLFEAESDNDGQSEIKEDVSPKKKKKKSKEGEDRSADDLKKKKSKSAKVKEKPRTECESSSGTLGLDSKPKKRTSETKEDSKDPKKQRKEDSKEVKKKKGEVKDVKIKTKEDSKESKKSRKEKQGDAQFDTETSALDDALLQEIDNENPGLYSENKEEEQQVKCEKERVEEETAEKDSIADRQLDGSASNEDDSVEVKAKRKKKKNQKVEDYKEEGRKVEIKDIYLEKKSMLKKQKSQEKVKVVAAELEKVSAAPVSAQKALKVSAEERGRKAMESAEEEKEIKKSEMKEKSVKKESEKEEKIRKEQKVVKSYKDIKSALDMFNVASEEKKEYSENNCKREEPSLEYKFIEELKLKDSKVHKERRIKDEAETWNYVAAGGGREVVDVCHMENSDGKQQVLSLGMDMQLEWLTLEDFQKHLDGEDENHISAEPISSTLLRDAVKSGDYMTVKMALSSSEEYNLDQEDSSGMTLVMLAAAGGHDDLLRVLIRKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAYVNMQQSSGETALMKACKRGNSDIVRLMIESGADCNILSKHQNSALHFAKQCNNVLVYEQLKSHLETLSRVAEDTIRDYFEARLVLLEPVFPIACHRLCEGPDFSTDFNYKPPQNVPEGSGILLFIFHANFFGKEVVARLCGPCSVQAVVLNDKFQLPVFLDSHFIYSFSPTAGLNKLFIRLAEAPTAKVKLLIGAYRVQLQ", "length": 858 }, "evidence": [ { "id": "A0AAA9SNL2", "url": "https://omabrowser.org/oma/group/A0AAA9SNL2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3TYA6-1", "protein_name": "M-phase phosphoprotein 8", "gene_name": "Mphosph8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAEEGMSAAALVMSVPDSIGRSPESEGVGAGDEEKDAATKGTVAVGDSEEDGEDVFEVERILDMKCEGGKNLYKVRWKGYTSEDDTWEPEVHLEDCKEVLLEFRKKLAENKAKAVRKDIQRLSLNNDIFEADSDSDQQSDTKEDISPRKKKKKIKCKEETSPEDLRKKRTKMGKLKDKFKTELESTSEIIGFDVKTKKRIWEVKEELKDSKKPKKDEIKETKELKKANKRAEVRDLKIKIREDVKENRKTKKERYIESPLESESPNDSLILEDDSEDFISDNREENQNVRSVRDKTAQETVQEGIFEKHLDDLISIEEDAGTRVRRKKTKPRKFEEPKEIKKLESTNAFLERRAIPKKQRNQDKGISNLELNKLPSPVFAQTLKSSRLSGEEKSLKSPDLAEEEKEKKNEPKGKYQKRYDLDKEEKARKEPKVLKSFKEIRNAFDLFKKTTEEKNDVLENNSKREEISLDSKIMNDNKTKDKCSLKEKRNTRDETDTWAYIAAEGDQEVSDSVCQTDETSDGRQPVLSLGMDLQLEWMKLEDFQKHLDGEDEPFITTNRIPNNLLRDAVKNGDYIAVKVALNSNEEYNLDQEDSTGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLALLEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLGKDVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKVKLLIGAYRVQLQ", "length": 858 }, "evidence": [ { "id": "A0AAA9SNL2", "url": "https://omabrowser.org/oma/group/A0AAA9SNL2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99549-1", "protein_name": "M-phase phosphoprotein 8", "gene_name": "MPHOSPH8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIHLEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKERRNTRDETDTWAYIAAEGDQEVLDSVCQADENSDGRQQILSLGMDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFAKQSNNVLVYDLLKNHLETLSRVAEETIKDYFEARLALLEPVFPIACHRLCEGPDFSTDFNYKPPQNIPEGSGILLFIFHANFLGKEVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPSAKVKLLIGAYRVQLQ", "length": 860 }, "evidence": [ { "id": "A0AAA9SNL2", "url": "https://omabrowser.org/oma/group/A0AAA9SNL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" }, { "name": "heterochromatin", "id": "GO:0000792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000792", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" }, { "name": "constitutive heterochromatin formation", "id": "GO:0140719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140719", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" }, { "name": "histone H3K9me2/3 reader activity", "id": "GO:0062072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062072", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 629, "end_pos": 631, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL2" }, { "id": "PS50013", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chromo", "eco_id": "ECO_0000259", "start_pos": 63, "end_pos": 122, "start_aa": "Phe", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 352, "end_pos": 354 }, { "start_pos": 554, "end_pos": 556 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 629, "end_pos": 631 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNN6-1", "uniprot_ac": "A0AAA9SNN6", "uniprot_id": "A0AAA9SNN6_BOVIN", "mass": { "chemical_mass": 27122.0, "monoisotopic_mass": 27122.0 }, "refseq": {}, "gene_names": [ { "name": "SARNP", "type": "recommended", "evidence": [ { "id": "A0AAA9SNN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ] } ], "protein_names": [ { "name": "SAP domain-containing ribonucleoprotein", "type": "recommended", "evidence": [ { "id": "A0AAA9SNN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6/entry#names_and_taxonomy" } ] }, { "name": "Nuclear protein Hcc-1", "type": "synonym", "evidence": [ { "id": "A0AAA9SNN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6#function" }, { "database": "UniProtKB", "id": "ARBA00054093", "url": "https://www.uniprot.org/uniprotkb/ARBA00054093#function" }, { "database": "UniProtKB", "id": "F6RNN0", "url": "https://www.uniprot.org/uniprotkb/F6RNN0#function" }, { "database": "UniProtKB", "id": "A0AAA9TNG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SARNP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6", "locus": { "chromosome": "5", "start_pos": 57498922, "end_pos": 57449223, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020662", "url": "https://www.ensembl.org/id/ENSBTAG00000020662" } ] } } ], "crossref": [ { "id": "A0AAA9SNN6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46551:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46551:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RNN0", "url": "https://www.uniprot.org/uniprotkb/F6RNN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RNN0-1", "url": "https://www.uniprot.org/uniprotkb/F6RNN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "KPSFILILKIGLKSETSELAVGFTIFWLGSFCKLRKSFILFSQLAELKQECLARGLETKGIKQDLINRLQAYLEEHAEEEANEEDVLGDETEEEEPKPLELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLESKKAARAARFGISPVPSKGLSSDTKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA", "length": 241, "header": "tr|A0AAA9SNN6-1|A0AAA9SNN6_BOVIN Isoform 1 of SAP domain-containing ribonucleoprotein OS=Bos taurus OX=9913 GN=SARNP PE=1 SV=1 CANONICAL=A0AAA9SNN6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6/entry#A0AAA9SNN6-1", "sequence": { "sequence": "KPSFILILKIGLKSETSELAVGFTIFWLGSFCKLRKSFILFSQLAELKQECLARGLETKGIKQDLINRLQAYLEEHAEEEANEEDVLGDETEEEEPKPLELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLESKKAARAARFGISPVPSKGLSSDTKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA", "length": 241, "header": "tr|A0AAA9SNN6-1|A0AAA9SNN6_BOVIN Isoform 1 of SAP domain-containing ribonucleoprotein OS=Bos taurus OX=9913 GN=SARNP PE=1 SV=1 CANONICAL=A0AAA9SNN6-1" }, "locus": { "chromosome": "5", "start_pos": 57498691, "end_pos": 57454590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097582.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097582.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087942.1" } ] } }, { "isoform_ac": "A0AAA9TNG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6/entry#A0AAA9TNG4-1", "sequence": { "sequence": "GGEGPGRTFPETRFCWRVGAFSLKLAELKQECLARGLETKGIKQDLINRLQAYLEEHAEEEANEEDVLGDETEEEEPKPLELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLESKKAARAARFGISPVPSKGLSSDTKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA", "length": 222, "header": "tr|A0AAA9TNG4-1|A0AAA9TNG4_BOVIN Computationally mapped isoform of SAP domain-containing ribonucleoprotein OS=Bos taurus OX=9913 GN=SARNP PE=1 SV=1 CANONICAL=A0AAA9SNN6-1" }, "locus": { "chromosome": "5", "start_pos": 57498691, "end_pos": 57449501, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104554.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104554.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098793.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098793.1" } ] } }, { "isoform_ac": "F6RNN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6/entry#F6RNN0-1", "sequence": { "sequence": "MKGMDLSPEKGSFCKLRKSFILFSQLAELKQECLARGLETKGIKQDLINRLQAYLEEHAEEEANEEDVLGDETEEEEPKPLELPVKEEEPPEKTVDVAAEKKVVKITSEIPQTERMQKRAERFNVPVSLESKKAARAARFGISPVPSKGLSSDTKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA", "length": 223, "header": "tr|F6RNN0-1|F6RNN0_BOVIN Computationally mapped isoform of SAP domain-containing ribonucleoprotein OS=Bos taurus OX=9913 GN=SARNP PE=1 SV=1 CANONICAL=A0AAA9SNN6-1" }, "locus": { "chromosome": "5", "start_pos": 57498691, "end_pos": 57451232, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027539.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027539.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027539.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027539.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" }, { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" }, { "name": "transcription export complex", "id": "GO:0000346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000346", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN6" }, { "id": "PS50800", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50800" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAP", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 73, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNN9-1", "uniprot_ac": "A0AAA9SNN9", "uniprot_id": "A0AAA9SNN9_BOVIN", "mass": { "chemical_mass": 105769.0, "monoisotopic_mass": 105769.0 }, "refseq": { "ac": "XP_024851994", "name": "gamma-aminobutyric acid type B receptor subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851994" }, "gene_names": [ { "name": "GABBR2", "type": "recommended", "evidence": [ { "id": "A0AAA9SNN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ] }, { "name": "GABBR2", "type": "synonym", "evidence": [ { "id": "XP_024851994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851994" } ] } ], "protein_names": [ { "name": "Gamma-aminobutyric acid type B receptor subunit 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SNN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9/entry#names_and_taxonomy" } ] }, { "name": "gamma-aminobutyric acid type B receptor subunit 2", "type": "synonym", "evidence": [ { "id": "XP_024851994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851994" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GABBR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9", "locus": { "chromosome": "8", "start_pos": 63382056, "end_pos": 63750130, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013810", "url": "https://www.ensembl.org/id/ENSBTAG00000013810" } ] } } ], "crossref": [ { "id": "A0AAA9SNN9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013810", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013810", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06366", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06366", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15294", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15294", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517040", "url": "https://www.ncbi.nlm.nih.gov/gene/517040", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517040", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517040", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MIZ5", "url": "https://www.orthodb.org/?gene=F1MIZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10519", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10519", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10519:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10519:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00003", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00003", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296041", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-977444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-997272", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024851994", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ5", "url": "https://www.uniprot.org/uniprotkb/F1MIZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPPSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHAEANSSRCLRKHLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAVLKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL", "length": 941, "header": "tr|A0AAA9SNN9-1|A0AAA9SNN9_BOVIN Isoform 1 of Gamma-aminobutyric acid type B receptor subunit 2 OS=Bos taurus OX=9913 GN=GABBR2 PE=3 SV=1 CANONICAL=A0AAA9SNN9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9/entry#A0AAA9SNN9-1", "sequence": { "sequence": "MASPPSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHAEANSSRCLRKHLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAVLKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL", "length": 941, "header": "tr|A0AAA9SNN9-1|A0AAA9SNN9_BOVIN Isoform 1 of Gamma-aminobutyric acid type B receptor subunit 2 OS=Bos taurus OX=9913 GN=GABBR2 PE=3 SV=1 CANONICAL=A0AAA9SNN9-1" }, "locus": { "chromosome": "8", "start_pos": 63749931, "end_pos": 63383032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134243.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134243.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085570.1" } ] } }, { "isoform_ac": "F1MIZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9/entry#F1MIZ5-1", "sequence": { "sequence": "MLSLAARHRAPVQYQPQETWPGHGSSLQCDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHAEANSSRCLRKHLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAVLKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL", "length": 862, "header": "tr|F1MIZ5-1|F1MIZ5_BOVIN Computationally mapped isoform of Gamma-aminobutyric acid type B receptor subunit 2 OS=Bos taurus OX=9913 GN=GABBR2 PE=3 SV=4 CANONICAL=A0AAA9SNN9-1" }, "locus": { "chromosome": "8", "start_pos": 63655021, "end_pos": 63383032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018355.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018355.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018355.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018355.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 922, "start_aa": "Thr", "end_pos": 922, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr922", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517040", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517040", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296041", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "resource": "Reactome", "description": "Activation of G protein gated Potassium channels" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" }, { "id": "R-BTA-977444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977444", "resource": "Reactome", "description": "GABA B receptor activation" }, { "id": "R-BTA-997272", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "resource": "Reactome", "description": "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" }, { "name": "GABA receptor complex", "id": "GO:1902710", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902710", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" }, { "name": "G protein-coupled receptor heterodimeric complex", "id": "GO:0038039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "id": "GO:0007193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007193", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" }, { "name": "gamma-aminobutyric acid signaling pathway", "id": "GO:0007214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" }, { "name": "G protein-coupled GABA receptor activity", "id": "GO:0004965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 404, "end_pos": 406, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 680, "end_pos": 682, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" }, { "start_pos": 867, "end_pos": 869, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNN9" }, { "id": "PS50259", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50259" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 3 profile", "eco_id": "ECO_0000259", "start_pos": 481, "end_pos": 763, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 922 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 404, "end_pos": 406 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 680, "end_pos": 682 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 842, "end_pos": 844 }, { "start_pos": 867, "end_pos": 869 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNQ9-1", "uniprot_ac": "A0AAA9SNQ9", "uniprot_id": "A0AAA9SNQ9_BOVIN", "mass": { "chemical_mass": 39987.0, "monoisotopic_mass": 39987.0 }, "refseq": { "ac": "XP_015315372", "name": "G-protein coupled receptor 55", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315372" }, "gene_names": [ { "name": "GPR55", "type": "recommended", "evidence": [ { "id": "A0AAA9SNQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ] }, { "name": "GPR55", "type": "synonym", "evidence": [ { "id": "XP_015315372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315372" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 55", "type": "synonym", "evidence": [ { "id": "A0AAA9SNQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 55", "type": "synonym", "evidence": [ { "id": "XP_015315372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315372" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9", "locus": { "chromosome": "2", "start_pos": 118711908, "end_pos": 118767490, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059603", "url": "https://www.ensembl.org/id/ENSBTAG00000059603" } ] } } ], "crossref": [ { "id": "539107", "url": "https://www.ncbi.nlm.nih.gov/gene/539107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539107", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCFHNMS", "url": "https://omabrowser.org/oma/group/TCFHNMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24232:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24232:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015315372", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315372", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQQNHSENCSFNDVKQLMETVQLAVHIPTFILGLLLNVLAIRGFSSFLKKRWPCYTATSIYMINLAVFDLLLVLSLPFKMFLSRRQGSFLPFCTLVECLYFISMYGSIFTICFISLDRFLAIRYPILVSHIRSPRKIFGICCIIWVLVWVGSTPVYSFHGKVQNYTCFNNMTDGTWSAKVFFPFEVFGFLLPMSIIGFCSSRSIHILVARRDHTRDWVQQKACIWTIAVSLAVFVVSFLPVHLSFFLQFLVRNGFIVECRAKQNIILFLQLSMCFSNFNCCLDVFCYYFVIKEFRMDIMAHRPSRSQLVHQDTLTTMAKGKKSCLEEGNLNLNSIVNIPSQGPDVVG", "length": 348, "header": "tr|A0AAA9SNQ9-1|A0AAA9SNQ9_BOVIN Isoform 1 of G protein-coupled receptor 55 OS=Bos taurus OX=9913 GN=GPR55 PE=3 SV=1 CANONICAL=A0AAA9SNQ9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9/entry#A0AAA9SNQ9-1", "sequence": { "sequence": "MSQQNHSENCSFNDVKQLMETVQLAVHIPTFILGLLLNVLAIRGFSSFLKKRWPCYTATSIYMINLAVFDLLLVLSLPFKMFLSRRQGSFLPFCTLVECLYFISMYGSIFTICFISLDRFLAIRYPILVSHIRSPRKIFGICCIIWVLVWVGSTPVYSFHGKVQNYTCFNNMTDGTWSAKVFFPFEVFGFLLPMSIIGFCSSRSIHILVARRDHTRDWVQQKACIWTIAVSLAVFVVSFLPVHLSFFLQFLVRNGFIVECRAKQNIILFLQLSMCFSNFNCCLDVFCYYFVIKEFRMDIMAHRPSRSQLVHQDTLTTMAKGKKSCLEEGNLNLNSIVNIPSQGPDVVG", "length": 348, "header": "tr|A0AAA9SNQ9-1|A0AAA9SNQ9_BOVIN Isoform 1 of G protein-coupled receptor 55 OS=Bos taurus OX=9913 GN=GPR55 PE=3 SV=1 CANONICAL=A0AAA9SNQ9-1" }, "locus": { "chromosome": "2", "start_pos": 118715459, "end_pos": 118714416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129586.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129586.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090810.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090810.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539107", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539107", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A4Z4-1", "protein_name": "G protein-coupled receptor 55", "gene_name": "GPR55", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRKLSPREGSDSPQSRLVTKLGGEMTSHSLLSCTGPPTGKNMNQLNQSKDCNFNDVDKLMKTVQMTVNIPTFLLGLLLNLLAIRGFSSFLKKRWPYYAATSIYMINLAVFDLLLVLSLPFKMALSHVKAPFLPFCTLVECLYFISMYGSIFTICFISLDRFLAIRYPLLVSHLRSPRKVLGICCIIWVLLWVGSTPVYSFHQKEENYTCFHNLSDGTWSVKVLLPLEVFGFLLPMSIMGFCSSRSICILVRRRNHTQDWVQQKTCIWTIAANLVVFVVSFLPVHLSFFLQFLVRNGFIMECRTRQNISLFVQLSMCFSNFNCCLDVFCYYFVIKEFRMDIMTHHRPSRVQVVRQDTMTTRG", "length": 361 }, "evidence": [ { "id": "A0AAA9SNQ9", "url": "https://omabrowser.org/oma/group/A0AAA9SNQ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1MAK4-1", "protein_name": "G protein-coupled receptor 55", "gene_name": "Gpr55", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQLDSNNCSFVFVDNLTKTLQLAVHIPTFLLGLVLNLLAIRGFGAFLKRRQLEYMATSIYMINLAVFDLLLVLSLPFKMILPQVKSSPSLVFCTFVECLYFISMYGSVFTICFISLDRLLAIQYPLLVNHFRSPRKTFGICCIIWMLVWVGSIPIYTFHRGVEGYKCFHNMSDSTWSARVFFPLEIFGFLLPMGIMGFCSYRSIHILLSIQGDDQWVRKRACIIWTIATNLVVFVVSFLPVHLGLFLQFLVRNGFILNCRVKQGISLFLQLSLCFSNINCCLDVFCYYFAIKEFRMGIKVHRPSQVQLVHQDSMVSRA", "length": 319 }, "evidence": [ { "id": "A0AAA9SNQ9", "url": "https://omabrowser.org/oma/group/A0AAA9SNQ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NRF0-1", "protein_name": "G protein-coupled receptor 55", "gene_name": "GPR55", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTNISGECNFTSIDRLAETLRFGISIPTFILGLVLNTLALSVFCCFWKKQTKTSIYMINLALADVLLLLSLPLKLHYSVAEAPGLLCAFIQSLYFVNTYGSIFIIVCITVDRYICLKHPFEGRANQSPRWAILICCFIWAVTWLCSSPIYVFQKKDSLKCFHNMSDEAWSVPLIVSVEIFGFLIPLSVMVFCSAQNIWILLNHKNRAKEKADSLRVIIINLVVFLVCFTPVHLAICLQCLVRQHVIVDCRLKQTISLFIQLSMILANLNCCLDAIFYYFAAKEFREKTHLKKIIERCPVFKPCAT", "length": 305 }, "evidence": [ { "id": "A0AAA9SNQ9", "url": "https://omabrowser.org/oma/group/A0AAA9SNQ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IH69-1", "protein_name": "G-protein coupled receptor 55", "gene_name": "Gpr55", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSRPYASDNCSFDDVDKLMSTLQLAVHIPTFLLGLVLNLLAIRGFSTFLKKKQLEYIATSIYMINLAVFDLLLVLSLPFKMALPQVESPPQVFCTLVECLYFISMYGSIFTICFISVDRFLAIQYPLLVNHLRSPRKAFGICCSLWILVWVGSIPIYTFHREVEKYKCFHNMSDGTWSAKVFFPLEIFGFLLPMGIMGFCSYRIIHILLRCRNPVQQRACIWTIATNLVIFVVSFLPVHLGFFLQFLVRNGFIVECRAKQNISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMGIKGPQASTVELVRQDTMISRGYGEVPLSKEGDPSPEFS", "length": 332 }, "evidence": [ { "id": "A0AAA9SNQ9", "url": "https://omabrowser.org/oma/group/A0AAA9SNQ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3UJF0-1", "protein_name": "G protein-coupled receptor 55", "gene_name": "Gpr55", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQPERDNCSFDSVDKLTRTLQLAVHIPTFLLGLVLNLLAIRGFSAFLKKRKLDYIATSIYMINLAVFDLLLVLSLPFKMVLPQVESPLPSFCTLVECLYFISMYGSVFTICFISLDRFLAIQYPILASHLRSPRKTFGICCIIWMLVWIGSIPIYTFHREVERYKCFHNMSDVTWSASVFFPLEIFGFLLPMGIMGFCSYRSIHILLRRPDSTEDWVQQRDTKGWVQKRACIWTIATNLVIFVVSFLPVHLGFFLQYLVRNRFILDCRMKQGISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMRIKAHRPSTIKLVNQDTMVSRG", "length": 327 }, "evidence": [ { "id": "A0AAA9SNQ9", "url": "https://omabrowser.org/oma/group/A0AAA9SNQ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2T6-1", "protein_name": "G protein-coupled receptor 55", "gene_name": "GPR55", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG", "length": 319 }, "evidence": [ { "id": "A0AAA9SNQ9", "url": "https://omabrowser.org/oma/group/A0AAA9SNQ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" }, { "name": "bone resorption", "id": "GO:0045453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045453", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" }, { "name": "positive regulation of Rho protein signal transduction", "id": "GO:0035025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" }, { "name": "negative regulation of osteoclast differentiation", "id": "GO:0045671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045671", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cannabinoid receptor activity", "id": "GO:0004949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004949", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNQ9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 288, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNR2-1", "uniprot_ac": "A0AAA9SNR2", "uniprot_id": "A0AAA9SNR2_BOVIN", "mass": { "chemical_mass": 29084.0, "monoisotopic_mass": 29084.0 }, "refseq": {}, "gene_names": [ { "name": "LOC515358", "type": "recommended", "evidence": [ { "id": "A0AAA9SNR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2" } ] } ], "protein_names": [ { "name": "PUA domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SNR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC515358", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SNR2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNR2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21155", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21155", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004521", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004521", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22798", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22798", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22798:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22798:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01472", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01472", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFKKFDEKENVSNCIQLKTSVIKGIKNQLMEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPRQQVDKGAIKFVLSGANIMCPGLTSPGARLFPAAVDTVVAIMAEGKQHALCVGVMKMSADEIEKVNKGIGIENIHYLNDGLWHMKTYNIRVFSNESALRIRWPKDWSFSFNISISNEHPGLISFRMDWLDLLAVQGTPRSPRVFSNTTVQKHQFFSSQLSL", "length": 254, "header": "tr|A0AAA9SNR2-1|A0AAA9SNR2_BOVIN Isoform 1 of PUA domain-containing protein OS=Bos taurus OX=9913 GN=LOC515358 PE=3 SV=1 CANONICAL=A0AAA9SNR2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2/entry#A0AAA9SNR2-1", "sequence": { "sequence": "MFKKFDEKENVSNCIQLKTSVIKGIKNQLMEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPRQQVDKGAIKFVLSGANIMCPGLTSPGARLFPAAVDTVVAIMAEGKQHALCVGVMKMSADEIEKVNKGIGIENIHYLNDGLWHMKTYNIRVFSNESALRIRWPKDWSFSFNISISNEHPGLISFRMDWLDLLAVQGTPRSPRVFSNTTVQKHQFFSSQLSL", "length": 254, "header": "tr|A0AAA9SNR2-1|A0AAA9SNR2_BOVIN Isoform 1 of PUA domain-containing protein OS=Bos taurus OX=9913 GN=LOC515358 PE=3 SV=1 CANONICAL=A0AAA9SNR2-1" }, "locus": { "chromosome": "13", "start_pos": 43901733, "end_pos": 43896807, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120124.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120124.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086998.1" } ] } }, { "isoform_ac": "A0AAA9SPJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2/entry#A0AAA9SPJ3-1", "sequence": { "sequence": "MFKKFDEKENVSNCIQLKTSVIKGIKNQLMEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPRQQVDKGAIKFVLSGANIMCPGLTSPGARLFPAAVDTVVAIMAEGKQHALCVGVMKMSADEIEKVNKGIGIENIHYLNDGLWHMKTYKGLRFHSWSGKLRTFSEAKKTE", "length": 202, "header": "tr|A0AAA9SPJ3-1|A0AAA9SPJ3_BOVIN Computationally mapped isoform of Malignant T-cell-amplified sequence OS=Bos taurus OX=9913 GN=LOC515358 PE=3 SV=1 CANONICAL=A0AAA9SNR2-1" }, "locus": { "chromosome": "13", "start_pos": 43897821, "end_pos": 43896807, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112242.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112242.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085850.1" } ] } }, { "isoform_ac": "A0AAA9SRV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2/entry#A0AAA9SRV1-1", "sequence": { "sequence": "MFKKFDEKENVSNCIQLKTSVIKGIKNQLMEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPRQQVDKGAIKFVLSGANIMCPGLTSPGARLFPAAVDTVVAIMAEGKQHALCVGVMKMSADEIEKVNKGIGIENIHYLNDGLWHMKTYKLKRKQTASNSSSFFPCENTVSPLWN", "length": 206, "header": "tr|A0AAA9SRV1-1|A0AAA9SRV1_BOVIN Computationally mapped isoform of Malignant T-cell-amplified sequence OS=Bos taurus OX=9913 GN=LOC515358 PE=3 SV=1 CANONICAL=A0AAA9SNR2-1" }, "locus": { "chromosome": "13", "start_pos": 43918596, "end_pos": 43896807, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113533.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113533.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086803.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation reinitiation", "id": "GO:0002188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002188", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR2" }, { "id": "SM00359", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00359" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PUA", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 171, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 239, "end_pos": 241 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNS0-1", "uniprot_ac": "A0AAA9SNS0", "uniprot_id": "A0AAA9SNS0_BOVIN", "mass": { "chemical_mass": 35120.0, "monoisotopic_mass": 35120.0 }, "refseq": { "ac": "NP_001376710", "name": "olfactory receptor family 9 subfamily G member 4", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376710" }, "gene_names": [ { "name": "OR9G4", "type": "recommended", "evidence": [ { "id": "A0AAA9SNS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0" } ] }, { "name": "OR9G4", "type": "synonym", "evidence": [ { "id": "NP_001376710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376710" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SNS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 9G4", "type": "synonym", "evidence": [ { "id": "NP_001376710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376710" } ] }, { "name": "olfactory receptor family 9 subfamily G member 4", "type": "synonym", "evidence": [ { "id": "NP_001376710", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376710" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376710" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0", "locus": { "chromosome": "15", "start_pos": 79497699, "end_pos": 79498637, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068090", "url": "https://www.ensembl.org/id/ENSBTAG00000068090" } ] } } ], "crossref": [ { "id": "A0AAA9SNS0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "506891", "url": "https://www.ncbi.nlm.nih.gov/gene/506891", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376710", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVGNRTILTEFILLGLSTDPQWQLILFGVFLTVYLVTLSGNMTLVILIHIDSHLHTPMYFFIGNLSFLDFWYTSVYTPRILATCISEDKRFSLAECGAQLFFSCVVAYTECYLLAAMAYDRHMAICNPLLYSSSMSHSVCSRLVAGSYIGGFSNAIAHTANTFRLSFCGKNIIDHFFCDAPPLVKMSCTDTKVYEQVLLGLVGFTVLSSILVIIISYFHILLAILRIRTASGRHKAFSTCASHLVSVMLFYGSLLFMYSRPSSTYSLKRDKVAALFYTVVNPLLNPLIYSLRNKDVKEAFWKAAKTIRPQR", "length": 312, "header": "tr|A0AAA9SNS0-1|A0AAA9SNS0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9G4 PE=3 SV=1 CANONICAL=A0AAA9SNS0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0/entry#A0AAA9SNS0-1", "sequence": { "sequence": "MDVGNRTILTEFILLGLSTDPQWQLILFGVFLTVYLVTLSGNMTLVILIHIDSHLHTPMYFFIGNLSFLDFWYTSVYTPRILATCISEDKRFSLAECGAQLFFSCVVAYTECYLLAAMAYDRHMAICNPLLYSSSMSHSVCSRLVAGSYIGGFSNAIAHTANTFRLSFCGKNIIDHFFCDAPPLVKMSCTDTKVYEQVLLGLVGFTVLSSILVIIISYFHILLAILRIRTASGRHKAFSTCASHLVSVMLFYGSLLFMYSRPSSTYSLKRDKVAALFYTVVNPLLNPLIYSLRNKDVKEAFWKAAKTIRPQR", "length": 312, "header": "tr|A0AAA9SNS0-1|A0AAA9SNS0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9G4 PE=3 SV=1 CANONICAL=A0AAA9SNS0-1" }, "locus": { "chromosome": "15", "start_pos": 79498637, "end_pos": 79497702, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106431.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106431.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085596.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085596.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNS0" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNT8-1", "uniprot_ac": "A0AAA9SNT8", "uniprot_id": "A0AAA9SNT8_BOVIN", "mass": { "chemical_mass": 36637.0, "monoisotopic_mass": 36637.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SNT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SNT8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEVTTEDISWNESISETNHSTVTEFIFLGLSNSQELQIFLFVFFFVFYVGIVFGNLLIVITVASDSHLHSPMYFLLANLSLIDLRLSSVTAPKTIADFFSKCKVISFKGCLAQIFLLHFFGGSELMILIAMAFDRYVAICKPLHYTTIMRGYVCVGFVAAAWGTGFLHSVSQLAFAVNLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFLLITSYTVILVTIQHLPSERSSKALSTLTAHITVVLLFFGPCIFIYAWPFPIESLDKFLAVFCSVVTPFLNPMIYTLRNKDMKTAMRWLRKWNINSRIKS", "length": 325, "header": "tr|A0AAA9SNT8-1|A0AAA9SNT8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SNT8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8/entry#A0AAA9SNT8-1", "sequence": { "sequence": "MKEVTTEDISWNESISETNHSTVTEFIFLGLSNSQELQIFLFVFFFVFYVGIVFGNLLIVITVASDSHLHSPMYFLLANLSLIDLRLSSVTAPKTIADFFSKCKVISFKGCLAQIFLLHFFGGSELMILIAMAFDRYVAICKPLHYTTIMRGYVCVGFVAAAWGTGFLHSVSQLAFAVNLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFLLITSYTVILVTIQHLPSERSSKALSTLTAHITVVLLFFGPCIFIYAWPFPIESLDKFLAVFCSVVTPFLNPMIYTLRNKDMKTAMRWLRKWNINSRIKS", "length": 325, "header": "tr|A0AAA9SNT8-1|A0AAA9SNT8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SNT8-1" }, "locus": { "chromosome": "10", "start_pos": 27791320, "end_pos": 27787724, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017630.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017630.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087995.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087995.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNT8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 300, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNV1-1", "uniprot_ac": "A0AAA9SNV1", "uniprot_id": "A0AAA9SNV1_BOVIN", "mass": { "chemical_mass": 88731.0, "monoisotopic_mass": 88731.0 }, "refseq": {}, "gene_names": [ { "name": "RAD54L", "type": "recommended", "evidence": [ { "id": "A0AAA9SNV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ] } ], "protein_names": [ { "name": "DNA repair and recombination protein RAD54-like", "type": "recommended", "evidence": [ { "id": "A0AAA9SNV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1/entry#names_and_taxonomy" } ] }, { "name": "RAD54 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SNV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1#function" }, { "database": "UniProtKB", "id": "ARBA00094353", "url": "https://www.uniprot.org/uniprotkb/ARBA00094353#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAD54L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1", "locus": { "chromosome": "3", "start_pos": 99814156, "end_pos": 99843507, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019901", "url": "https://www.ensembl.org/id/ENSBTAG00000019901" } ] } } ], "crossref": [ { "id": "A0AAA9SNV1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18793", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18793", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45629", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45629", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45629:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45629:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QH37", "url": "https://www.uniprot.org/uniprotkb/F6QH37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QH37-1", "url": "https://www.uniprot.org/uniprotkb/F6QH37-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRSLAPSQLAKRKPEDGPSDDEDWQPGAVTSKKPKKSSCETQSQECFLSPFRKPLTQLTNRPPCLDSSQHEAFIRSILSKPFKIPIPNYQGPLGSRALGLKRAGVRRALHDPLEEGALVLYEPPPLSAHDQLKFDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPDCKPEIDKAVVVSPSSLVRNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMNQRGARVPSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAQEFKKHFELPILKGRDAAASEEDRRVGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQIELYKRFLRQAKPAEELREGKMSVSSLSSITSLKKLCNHPALIYDKCVEEEDGFEGTLDIFPPGYNSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNNPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEAKLSDTHDRLRCRRCVNNHQVWPPPDGSDCTSDLAQWNHSTDKRGLKDEAVPWQPEALQCGVALHSSNHLGQKLGWALLKQTAEGEGNQPTGVYSTGSYPQASVRPESQNMIECGAACGC", "length": 790, "header": "tr|A0AAA9SNV1-1|A0AAA9SNV1_BOVIN Isoform 1 of DNA repair and recombination protein RAD54-like OS=Bos taurus OX=9913 GN=RAD54L PE=3 SV=1 CANONICAL=A0AAA9SNV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1/entry#A0AAA9SNV1-1", "sequence": { "sequence": "MRRSLAPSQLAKRKPEDGPSDDEDWQPGAVTSKKPKKSSCETQSQECFLSPFRKPLTQLTNRPPCLDSSQHEAFIRSILSKPFKIPIPNYQGPLGSRALGLKRAGVRRALHDPLEEGALVLYEPPPLSAHDQLKFDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPDCKPEIDKAVVVSPSSLVRNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMNQRGARVPSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAQEFKKHFELPILKGRDAAASEEDRRVGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQIELYKRFLRQAKPAEELREGKMSVSSLSSITSLKKLCNHPALIYDKCVEEEDGFEGTLDIFPPGYNSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNNPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEAKLSDTHDRLRCRRCVNNHQVWPPPDGSDCTSDLAQWNHSTDKRGLKDEAVPWQPEALQCGVALHSSNHLGQKLGWALLKQTAEGEGNQPTGVYSTGSYPQASVRPESQNMIECGAACGC", "length": 790, "header": "tr|A0AAA9SNV1-1|A0AAA9SNV1_BOVIN Isoform 1 of DNA repair and recombination protein RAD54-like OS=Bos taurus OX=9913 GN=RAD54L PE=3 SV=1 CANONICAL=A0AAA9SNV1-1" }, "locus": { "chromosome": "3", "start_pos": 99843408, "end_pos": 99814192, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101329.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101329.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088011.1" } ] } }, { "isoform_ac": "F6QH37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1/entry#F6QH37-1", "sequence": { "sequence": "MRRSLAPSQLAKRKPEDGPSDDEDWQPGAVTSKKPKKSSCETQSQECFLSPFRKPLTQLTNRPPCLDSSQHEAFIRSILSKPFKIPIPNYQGPLGSRALGLKRAGVRRALHDPLEEGALVLYEPPPLSAHDQLKFDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPDCKPEIDKAVVVSPSSLVRNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMNQRGARVPSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAQEFKKHFELPILKGRDAAASEEDRRVGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQIELYKRFLRQAKPAEELREGKMSVSSLSSITSLKKLCNHPALIYDKCVEEEDGFEGTLDIFPPGYNSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNNPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSVRIVVMFRVVVGHGIRPSGSPWVFLIASVAPLPVVVSKAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEAKLSDTHDRLRCRRCVNNHQVWPPPDGSDCTSDLAQWNHSTDKRGLKDEVLQAAWDAASTAITFVFHQRSHEEQRGLHL", "length": 787, "header": "tr|F6QH37-1|F6QH37_BOVIN Computationally mapped isoform of DNA repair and recombination protein RAD54-like OS=Bos taurus OX=9913 GN=RAD54L PE=3 SV=1 CANONICAL=A0AAA9SNV1-1" }, "locus": { "chromosome": "3", "start_pos": 99843408, "end_pos": 99817885, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026513.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026513.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026513.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026513.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "ATP-dependent DNA/DNA annealing activity", "id": "GO:0036310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" }, { "id": "PS51192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 346, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SNV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV1" }, { "id": "PS51194", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000259", "start_pos": 501, "end_pos": 654, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 708, "end_pos": 710 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNV6-1", "uniprot_ac": "A0AAA9SNV6", "uniprot_id": "A0AAA9SNV6_BOVIN", "mass": { "chemical_mass": 95581.0, "monoisotopic_mass": 95581.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF281", "type": "recommended", "evidence": [ { "id": "A0AAA9SNV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ] } ], "protein_names": [ { "name": "Zinc finger protein 281", "type": "recommended", "evidence": [ { "id": "A0AAA9SNV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6#function" }, { "database": "UniProtKB", "id": "ARBA00059547", "url": "https://www.uniprot.org/uniprotkb/ARBA00059547#function" }, { "database": "UniProtKB", "id": "G3N3V3", "url": "https://www.uniprot.org/uniprotkb/G3N3V3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF281", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6", "locus": { "chromosome": "16", "start_pos": 79114315, "end_pos": 79122094, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047428", "url": "https://www.ensembl.org/id/ENSBTAG00000047428" } ] } } ], "crossref": [ { "id": "A0AAA9SNV6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047428", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047428", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532401", "url": "https://www.ncbi.nlm.nih.gov/gene/532401", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532401", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532401", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FPPGMVM", "url": "https://omabrowser.org/oma/group/FPPGMVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N3V3", "url": "https://www.orthodb.org/?gene=G3N3V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3V3", "url": "https://www.uniprot.org/uniprotkb/G3N3V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3V3-1", "url": "https://www.uniprot.org/uniprotkb/G3N3V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVGSAFLSGGGGGAGSGGRAEMEPSFPPGMVMFNHRLPPVASFARPAGAAAPPPQCVLAAAPAAAPAAEPPPAPAPDVTFKKEPAAPGAAFPAQRTPWGFLQSLVSIKQEKPADPDEPPGAPHPHYGGLFAGADERAPGLGGGDGGGAGVIQDLSALHPPPPAPHQHPHPRDVLLGRTDDPRGPEEPKPDASVKKAKRPKPESQGIKAKRKPGASSKPPPAGDGEGSVLSPSQKPHVCDHCSAAFRSSYHLRRHVLIHTGERPFQCGQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYRCDTCQQYFSRTDRLLKHRRTCGEALGKGAPGAEPGSSGSHSGVGNLAVLSQGNTSSSRRKAKSKSLAVESKEPKAGKANESHLSTSMNTQSYSVEMPAVPSSGGIVGPDIDELQKRVPKLIFKKGSRKSTDKSYLNFVSPLPDLVGQKSLSGKPSGSLGIVSNSSVETISLLQSTGGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSVSVGHMVSPQSVIQSAGVGVLDSEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFSIAEPRVDLHASGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDVEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRARTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYRSALPAKVSLICHCKILRKRV", "length": 893, "header": "tr|A0AAA9SNV6-1|A0AAA9SNV6_BOVIN Isoform 1 of Zinc finger protein 281 OS=Bos taurus OX=9913 GN=ZNF281 PE=3 SV=1 CANONICAL=A0AAA9SNV6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6/entry#A0AAA9SNV6-1", "sequence": { "sequence": "MKVGSAFLSGGGGGAGSGGRAEMEPSFPPGMVMFNHRLPPVASFARPAGAAAPPPQCVLAAAPAAAPAAEPPPAPAPDVTFKKEPAAPGAAFPAQRTPWGFLQSLVSIKQEKPADPDEPPGAPHPHYGGLFAGADERAPGLGGGDGGGAGVIQDLSALHPPPPAPHQHPHPRDVLLGRTDDPRGPEEPKPDASVKKAKRPKPESQGIKAKRKPGASSKPPPAGDGEGSVLSPSQKPHVCDHCSAAFRSSYHLRRHVLIHTGERPFQCGQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYRCDTCQQYFSRTDRLLKHRRTCGEALGKGAPGAEPGSSGSHSGVGNLAVLSQGNTSSSRRKAKSKSLAVESKEPKAGKANESHLSTSMNTQSYSVEMPAVPSSGGIVGPDIDELQKRVPKLIFKKGSRKSTDKSYLNFVSPLPDLVGQKSLSGKPSGSLGIVSNSSVETISLLQSTGGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSVSVGHMVSPQSVIQSAGVGVLDSEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFSIAEPRVDLHASGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDVEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRARTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYRSALPAKVSLICHCKILRKRV", "length": 893, "header": "tr|A0AAA9SNV6-1|A0AAA9SNV6_BOVIN Isoform 1 of Zinc finger protein 281 OS=Bos taurus OX=9913 GN=ZNF281 PE=3 SV=1 CANONICAL=A0AAA9SNV6-1" }, "locus": { "chromosome": "16", "start_pos": 79121031, "end_pos": 79116586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088016.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088016.1" } ] } }, { "isoform_ac": "G3N3V3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6/entry#G3N3V3-1", "sequence": { "sequence": "MKVGSAFLSGGGGGAGSGGRAEMEPSFPPGMVMFNHRLPPVASFARPAGAAAPPPQCVLAAAPAAAPAAEPPPAPAPDVTFKKEPAAPGAAFPAQRTPWGFLQSLVSIKQEKPADPDEPPGAPHPHYGGLFAGADERAPGLGGGDGGGAGVIQDLSALHPPPPAPHQHPHPRDVLLGRTDDPRGPEEPKPDASVKKAKRPKPESQGIKAKRKPGASSKPPPAGDGEGSVLSPSQKPHVCDHCSAAFRSSYHLRRHVLIHTGERPFQCGQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYRCDTCQQYFSRTDRLLKHRRTCGEALGKGAPGAEPGSSGSHSGVGNLAVLSQGNTSSSRRKAKSKSLAVESKEPKAGKANESHLSTSMNTQSYSVEMPAVPSSGGIVGPDIDELQKRVPKLIFKKGSRKSTDKSYLNFVSPLPDLVGQKSLSGKPSGSLGIVSNSSVETISLLQSTGGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSVSVGHMVSPQSVIQSAGVGVLDSEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFSIAEPRVDLHASGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDVEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRARTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR", "length": 873, "header": "tr|G3N3V3-1|G3N3V3_BOVIN Computationally mapped isoform of Zinc finger protein 281 OS=Bos taurus OX=9913 GN=ZNF281 PE=3 SV=2 CANONICAL=A0AAA9SNV6-1" }, "locus": { "chromosome": "16", "start_pos": 79121031, "end_pos": 79118413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094465.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094465.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087607.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532401", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532401", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YGZ0-1", "protein_name": "Zinc finger protein 281", "gene_name": "LOC107053919", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKLGGGFLGGGKRAAAMEPGFPPGMVMFNHRLPPVTSFTRAAAPPPAAQHPPQCALPPPSAAASSAAEPPAPPAPQDVTFKKEPAGAFPSAPSSAQRGPWGFLQSLVSIKQEKPSEQEEEEPPPQHHHYGGLFGAPGEERPPGLGGGGGEGGGQSVIQDLSLLQHLHQHPPRDLLLGGRAEGGPGGSGEPKHDAQVKKAKRPKPETQGIKAKRKPGASSKPPLVGDAEGAVASPSQKPHVCEHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEAIGKAGAGMEPGSSHNMGSLAALSQGNTNSSRRKSKTKSISTENKGNKCSSKVAESQVTSNVAMPNYAVDIPIVSSSGGLVGTGVEELQKKVPKLVFKKGSRKQADKNYLNFVSPLPDILGQKPLSGKQSGSLGSLVANTSVENIGLLQSPSGKSGQINSNYDDAMQFSKKRRYLQTASGNSAFSINVGHMTSQQSVIQSAGVSVMDNETPLSLIDSASLNSEIKTCHDKSGIPDEVLQSLLDQYSHKSEGQKEDPFSITEQRVDLHSSGEHSEMVQEENLSPNSQTVSNDKASMLQEYSKYLQQAFERTTNSTGFAFGPSFQFVSLSSTLHNHTLFQDKQIYTTSPLECGFSQSVTSVLPTALPKPPFGMLLGSQPGFYLSALEATHQQLTPSQELDDLIDPQKTLETSSNYQSTSQKLTGQKEQKNLESSTSFQIPSQELASQIDPQKDIEPRATYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYSNMMSDVSEPCSTRVKTPTSQSYR", "length": 874 }, "evidence": [ { "id": "A0AAA9SNV6", "url": "https://omabrowser.org/oma/group/A0AAA9SNV6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QM98-1", "protein_name": "Zinc finger protein 281", "gene_name": "znf281b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSIIQDKLGNEFLRNGGMDPNYTPSMIMFSHLPPVTSFTRLTSQTSMADLPQEMILKKERDSPEHGGGFLHSMGIKQEKLNELDYHLPMYTTGIGTAGGKNTDMLDMSLGNHQNMLLHDLSLSNQFSGRLGKDPKETGPRKGRRANGEGLEGKARRKQGDSGKTLMLDGDAGPLSPSSKPHICEHCSAAFRSSYHLRRHVLIHTGERPFRCSQCNMSFIQKYLLQRHEKIHSGEKPFSCDQCNMRFIQKYHMERHKRTHSGEKPYKCDTCLQYFSRTDRLLKHKRTCGEAIKKGLDPGMLDLGDEDMGQGSYLLAQGNTSGPPRKKGKSKIGNDGGERRRKKGAAAGVRMARDDYNLDIPSGSGTASGALAEASMDNQHGGRTSKPVFKKGSRKGMDKCSVSVEEASHEQKLLTQKSSSMDMSGAGSMDGLGLLQNSGGTKQGGNSSNYDDAMQFLKKRRYLHAANSNATADFSSVHLPQPTVIQGGIGEPTLALLDTSPLVSVDKHDKSGIPDEVLQSLLDHYSHKSDGSHHDVTFDLQDSHHVELQPATGTSDLGPDNGSPGSGDKSGMMNEYSKFLLQTLERTSHSSNFILGPSGPFPSLMSSSSSPASSLYTTSPLECGFVQPVSSPLAPSSSTSLSKSHFGMLVGSPSPSHASPSSQQAFHLSSLEPTPHQQLTPSQELTDQLEKQHSPPYSLTSQELTNGGQKDQQTKNGSSSANGSNNGNVPSGGSSNGSVYSDLTALEPSKEVTYQIENFAQAFGSQFKSGRRTPLGYGGDPRVGVVEVDHRIQRTPVSEFSGYTSLLADVNEPASSGSKTPTSQSYR", "length": 826 }, "evidence": [ { "id": "A0AAA9SNV6", "url": "https://omabrowser.org/oma/group/A0AAA9SNV6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S5D4-1", "protein_name": "Zinc finger protein 281", "gene_name": "ZNF281", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKVGSAFLSGGGGGAGSGGRAEMEPSFPPGMVMFNHRLPPVASFARPAGAAAPPPQCVLAAAPAAAPAAEPPPAPAPDVTFKKEPAAPGAAFPAQRTSWGFLQSLVSIKQEKPAEPEEPPGAPHPHYGGLFAGADERAPALGGGDGGGPGVIQDLSVLHPPPAPHPRDVLLGGGGRTDDPRGPEEPKQDAGVKKAKRPKPESQGIKAKRKPSASSKPSLVGDGEGAVLSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEAIAKGAPNSEPGSSNHSSLGSLAVLSQGNTSSSRRKAKSKSLAIENKEPKTGKANESPISNSISMQNYSVEMPTVSSSGGVIGSGIDELQKRVPKLIFKKGSRKSTDKNYLNFVSPLPDLVGQKSLSGKPSGSLGIVSSSSVETIGLLQSTSGKQGQIGSNYDDAMQFSKKRRYLPTASSNSAFSVNVGHMVSQQSVIQSAGVGVLDSEAPLSLIDSSALNAEIKACHDKSGIPDEVLQSILDQYSSKSESQKEDPFSITEPRVDLHTSGDHSELVQEDNLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHSLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQASSQKLTSQKEQQKNLESSAGFQIPSQELASQIDPQKDVEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRARTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR", "length": 870 }, "evidence": [ { "id": "A0AAA9SNV6", "url": "https://omabrowser.org/oma/group/A0AAA9SNV6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q99LI5-1", "protein_name": "Zinc finger protein 281", "gene_name": "Znf281", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKIGSGFLSGGGGPSSSGGSGSGGSSGSASGGSGGGRRAEMEPTFPQSMVMFNHRLPPVTSFTRPAGTAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQPSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSLLHQHAQQQPAQHHRDVLLSSGSRTDEHGNQEPKQDANVKKAKRPKPESQGIKAKRKPSASSKPLVGEGEGAVLSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEAIAKGAASAEPGSSNHNSMGNLAVLSQGNTSSSRRKSKSKSIAIENKEHKTGKTNESQMSNNINMQSYSVEMPTVSTSGSIIGTGIDELQKRVPKLIFKKGSRKNADKSYLNFVSPLPDVVGQKSLSGKPGGSLGIVSNNSVETISLLQSTSGKQGPISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSGKSETQKEDPFNLTEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKTSMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR", "length": 893 }, "evidence": [ { "id": "A0AAA9SNV6", "url": "https://omabrowser.org/oma/group/A0AAA9SNV6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2X9-1", "protein_name": "Zinc finger protein 281", "gene_name": "ZNF281", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKIGSGFLSGGGGTGSSGGSGSGGGGSGGGGGGGSSGRRAEMEPTFPQGMVMFNHRLPPVTSFTRPAGSAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVLLSSSSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIKAKRKPSASSKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSAEPGSSNHTNMGNLAVLSQGNTSSSRRKTKSKSIAIENKEQKTGKTNESQISNNINMQSYSVEMPTVSSSGGIIGTGIDELQKRVPKLIFKKGSRKNTDKNYLNFVSPLPDIVGQKSLSGKPSGSLGIVSNNSVETIGLLQSTSGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFNIAEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNASFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQKNLESSTGFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR", "length": 895 }, "evidence": [ { "id": "A0AAA9SNV6", "url": "https://omabrowser.org/oma/group/A0AAA9SNV6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "embryonic body morphogenesis", "id": "GO:0010172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010172", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "stem cell differentiation", "id": "GO:0048863", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048863", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 678, "end_pos": 680, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 264, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 375, "end_pos": 377 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 485, "end_pos": 487 }, { "start_pos": 593, "end_pos": 595 }, { "start_pos": 626, "end_pos": 628 }, { "start_pos": 678, "end_pos": 680 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNW7-1", "uniprot_ac": "A0AAA9SNW7", "uniprot_id": "A0AAA9SNW7_BOVIN", "mass": { "chemical_mass": 16785.0, "monoisotopic_mass": 16785.0 }, "refseq": { "ac": "XP_024848816", "name": "ubiquitin-conjugating enzyme E2 D3 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848816" }, "gene_names": [ { "name": "UBE2D3", "type": "recommended", "evidence": [ { "id": "A0AAA9SNW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ] }, { "name": "UBE2D3P", "type": "synonym", "evidence": [ { "id": "XP_024848816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848816" } ] }, { "name": "UBE2D3", "type": "synonym", "evidence": [ { "id": "XP_024848816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848816" } ] } ], "protein_names": [ { "name": "Ubiquitin conjugating enzyme E2 D3", "type": "synonym", "evidence": [ { "id": "A0AAA9SNW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-conjugating enzyme E2 D3 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024848816", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848816" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE2D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7", "locus": { "chromosome": "6", "start_pos": 22042630, "end_pos": 22015230, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048761", "url": "https://www.ensembl.org/id/ENSBTAG00000048761" } ] } } ], "crossref": [ { "id": "A0AAA9SNW7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNW7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048761", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048761", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23792", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23792", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "326583", "url": "https://www.ncbi.nlm.nih.gov/gene/326583", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PNIASMY", "url": "https://omabrowser.org/oma/group/PNIASMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24068", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24068", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1234176", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-201451", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173795", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173795", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5205685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5357905", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8866654", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866654", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-937041", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-937041", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9705462", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9705462", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024848816", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848816", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5N0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5N0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRLAREWTEKYAML", "length": 148, "header": "tr|A0AAA9SNW7-1|A0AAA9SNW7_BOVIN Isoform 1 of Ubiquitin conjugating enzyme E2 D3 OS=Bos taurus OX=9913 GN=UBE2D3 PE=3 SV=1 CANONICAL=A0AAA9SNW7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7/entry#A0A3Q1M5N0-1", "sequence": { "sequence": "MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM", "length": 147, "header": "tr|A0A3Q1M5N0-1|A0A3Q1M5N0_BOVIN Computationally mapped isoform of Ubiquitin conjugating enzyme E2 D3 OS=Bos taurus OX=9913 GN=UBE2D3 PE=3 SV=1 CANONICAL=A0AAA9SNW7-1" }, "locus": { "chromosome": "6", "start_pos": 22041806, "end_pos": 22016256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066609.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066609.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063578.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063578.1" } ] } }, { "isoform_ac": "A0AAA9SNW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7/entry#A0AAA9SNW7-1", "sequence": { "sequence": "MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRLAREWTEKYAML", "length": 148, "header": "tr|A0AAA9SNW7-1|A0AAA9SNW7_BOVIN Isoform 1 of Ubiquitin conjugating enzyme E2 D3 OS=Bos taurus OX=9913 GN=UBE2D3 PE=3 SV=1 CANONICAL=A0AAA9SNW7-1" }, "locus": { "chromosome": "6", "start_pos": 22040253, "end_pos": 22016256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132420.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132420.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087058.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1234176", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "resource": "Reactome", "description": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" }, { "id": "R-BTA-201451", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "resource": "Reactome", "description": "Signaling by BMP" }, { "id": "R-BTA-2173795", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173795", "resource": "Reactome", "description": "Downregulation of SMAD2/3:SMAD4 transcriptional activity" }, { "id": "R-BTA-5205685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "resource": "Reactome", "description": "PINK1-PRKN Mediated Mitophagy" }, { "id": "R-BTA-5357905", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "resource": "Reactome", "description": "Regulation of TNFR1 signaling" }, { "id": "R-BTA-8866654", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866654", "resource": "Reactome", "description": "E3 ubiquitin ligases ubiquitinate target proteins" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" }, { "id": "R-BTA-937041", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-937041", "resource": "Reactome", "description": "IKK complex recruitment mediated by RIP1" }, { "id": "R-BTA-9705462", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9705462", "resource": "Reactome", "description": "Inactivation of CSF3 (G-CSF) signaling" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P15732-1", "protein_name": "Ubiquitin-conjugating enzyme E2-16 kDa", "gene_name": "UBC5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSSKRIAKELSDLGRDPPASCSAGPVGDDLYHWQASIMGPSDSPYAGGVFFLSIHFPTDYPFKPPKVNFTTKIYHPNINSSGNICLDILKDQWSPALTLSKVLLSICSLLTDANPDDPLVPEIAQIYKTDKAKYEATAKEWTKKYAV", "length": 148 }, "evidence": [ { "id": "A0AAA9SNW7", "url": "https://omabrowser.org/oma/group/A0AAA9SNW7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P25867-1", "protein_name": "Ubiquitin-conjugating enzyme E2-17 kDa", "gene_name": "eff", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MALKRINKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWTRKYAM", "length": 147 }, "evidence": [ { "id": "A0AAA9SNW7", "url": "https://omabrowser.org/oma/group/A0AAA9SNW7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P35133-1", "protein_name": "Ubiquitin-conjugating enzyme E2 10", "gene_name": "UBC10", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPSESPYAGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDKNKYESTARSWTQKYAMG", "length": 148 }, "evidence": [ { "id": "A0AAA9SNW7", "url": "https://omabrowser.org/oma/group/A0AAA9SNW7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNW7" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 147, "start_aa": "Met", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 41, "end_pos": 43 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNY6-1", "uniprot_ac": "A0AAA9SNY6", "uniprot_id": "A0AAA9SNY6_BOVIN", "mass": { "chemical_mass": 53263.0, "monoisotopic_mass": 53263.0 }, "refseq": { "ac": "NP_001179897", "name": "cerebellar degeneration-related protein 2-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179897" }, "gene_names": [ { "name": "CDR2L", "type": "recommended", "evidence": [ { "id": "A0AAA9SNY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6" } ] }, { "name": "CDR2L", "type": "synonym", "evidence": [ { "id": "NP_001179897", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179897" } ] } ], "protein_names": [ { "name": "Cerebellar deration related protein 2 like", "type": "synonym", "evidence": [ { "id": "A0AAA9SNY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6/entry#names_and_taxonomy" } ] }, { "name": "cerebellar degeneration-related protein 2-like", "type": "synonym", "evidence": [ { "id": "NP_001179897", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179897" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDR2L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6", "locus": { "chromosome": "19", "start_pos": 56431268, "end_pos": 56444030, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039466", "url": "https://www.ensembl.org/id/ENSBTAG00000039466" } ] } } ], "crossref": [ { "id": "A0AAA9SNY6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNY6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039466", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039466", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613582", "url": "https://www.ncbi.nlm.nih.gov/gene/613582", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613582", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613582", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AGPRTTW", "url": "https://omabrowser.org/oma/group/AGPRTTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJQ4", "url": "https://www.orthodb.org/?gene=E1BJQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19232:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19232:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27644", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27644", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179897", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJQ4", "url": "https://www.uniprot.org/uniprotkb/E1BJQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJQ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRAARMEDFTAEEEEPWYDQQDLEQDLHLAAELGKTLLERNKELEESLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLAARDLELTNQKLVLESKVAQQKIHGLTETIERLQTQVEELQAQVEQLRDLEQLRVRREKRERRRTIHTFPCLKELCTSPRCEDAFRLHSSSLELGPRPLEQENERLQTLVGVLRSQVSQERQRKERAEREYAAVLQEYSELERQLCEMEGCRFRVQELEAELLELQQMKQAKTYLLGREDHLAEALLAPLTQAPEADDPQPGIGDDSGPQDGVSSPAASPGHAVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRAGEEGLGETKAEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK", "length": 464, "header": "tr|A0AAA9SNY6-1|A0AAA9SNY6_BOVIN Isoform 1 of Cerebellar deration related protein 2 like OS=Bos taurus OX=9913 GN=CDR2L PE=3 SV=1 CANONICAL=A0AAA9SNY6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6/entry#A0AAA9SNY6-1", "sequence": { "sequence": "MRRAARMEDFTAEEEEPWYDQQDLEQDLHLAAELGKTLLERNKELEESLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLAARDLELTNQKLVLESKVAQQKIHGLTETIERLQTQVEELQAQVEQLRDLEQLRVRREKRERRRTIHTFPCLKELCTSPRCEDAFRLHSSSLELGPRPLEQENERLQTLVGVLRSQVSQERQRKERAEREYAAVLQEYSELERQLCEMEGCRFRVQELEAELLELQQMKQAKTYLLGREDHLAEALLAPLTQAPEADDPQPGIGDDSGPQDGVSSPAASPGHAVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRAGEEGLGETKAEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK", "length": 464, "header": "tr|A0AAA9SNY6-1|A0AAA9SNY6_BOVIN Isoform 1 of Cerebellar deration related protein 2 like OS=Bos taurus OX=9913 GN=CDR2L PE=3 SV=1 CANONICAL=A0AAA9SNY6-1" }, "locus": { "chromosome": "19", "start_pos": 56443831, "end_pos": 56432272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084589.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084589.1" } ] } }, { "isoform_ac": "A0AAA9SVG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6/entry#A0AAA9SVG0-1", "sequence": { "sequence": "MGRIPGEGNGNPLQYSCLENPLDRGAWWATVHRITKSRTRLKRLSMRAPVVYNLHLAAELGKTLLERNKELEESLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLAARDLELTNQKLVLESKVAQQKIHGLTETIERLQTQVEELQAQVEQLRDLEQLRVRREKRERRRTIHTFPCLKELCTSPRCEDAFRLHSSSLELGPRPLEQENERLQTLVGVLRSQVSQERQRKERAEREYAAVLQEYSELERQLCEMEGCRFRVQELEAELLELQQMKQAKTYLLGREDHLAEALLAPLTQAPEADDPQPGIGDDSGPQDGVSSPAASPGHAVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRAGEEGLGETKAEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK", "length": 490, "header": "tr|A0AAA9SVG0-1|A0AAA9SVG0_BOVIN Computationally mapped isoform of Cerebellar deration related protein 2 like OS=Bos taurus OX=9913 GN=CDR2L PE=3 SV=1 CANONICAL=A0AAA9SNY6-1" }, "locus": { "chromosome": "19", "start_pos": 56439305, "end_pos": 56432272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101225.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101225.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089311.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089311.1" } ] } }, { "isoform_ac": "E1BJQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6/entry#E1BJQ4-1", "sequence": { "sequence": "MSKLLDLHLAAELGKTLLERNKELEESLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLAARDLELTNQKLVLESKVAQQKIHGLTETIERLQTQVEELQAQVEQLRDLEQLRVRREKRERRRTIHTFPCLKELCTSPRCEDAFRLHSSSLELGPRPLEQENERLQTLVGVLRSQVSQERQRKERAEREYAAVLQEYSELERQLCEMEGCRFRVQELEAELLELQQMKQAKTYLLGREDHLAEALLAPLTQAPEADDPQPGIGDDSGPQDGVSSPAASPGHAVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRAGEEGLGETKAEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK", "length": 443, "header": "tr|E1BJQ4-1|A0AAA9SNY6_BOVIN Computationally mapped isoform of Cerebellar deration related protein 2 like OS=Bos taurus OX=9913 GN=CDR2L PE=3 SV=3 CANONICAL=A0AAA9SNY6-1" }, "locus": { "chromosome": "19", "start_pos": 56436855, "end_pos": 56432272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053747.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053747.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050825.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050825.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613582", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613582", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q86X02-1", "protein_name": "Cerebellar degeneration-related protein 2-like", "gene_name": "CDR2L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK", "length": 465 }, "evidence": [ { "id": "A0AAA9SNY6", "url": "https://omabrowser.org/oma/group/A0AAA9SNY6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 337, "end_pos": 339 }, { "start_pos": 454, "end_pos": 456 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP21-1", "uniprot_ac": "A0AAA9SP21", "uniprot_id": "A0AAA9SP21_BOVIN", "mass": { "chemical_mass": 38580.0, "monoisotopic_mass": 38580.0 }, "refseq": {}, "gene_names": [ { "name": "SDCBP", "type": "recommended", "evidence": [ { "id": "A0AAA9SP21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ] } ], "protein_names": [ { "name": "Syndecan binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SP21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDCBP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21", "locus": { "chromosome": "14", "start_pos": 24764187, "end_pos": 24729484, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019910", "url": "https://www.ensembl.org/id/ENSBTAG00000019910" } ] } } ], "crossref": [ { "id": "A0AAA9SP21", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP21", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06721", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06721", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06794", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06794", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510979", "url": "https://www.ncbi.nlm.nih.gov/gene/510979", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HKMIKKA", "url": "https://omabrowser.org/oma/group/HKMIKKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12345:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12345:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTGSPDRAPRACAGGKRGRCGDARRGRSSGARRPLPSGFQKSEPVTGGGARVSAASKNPAKMSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPVSQDGNLYPKLYPELSQYMGLSLNEEEIRANMALVPGAPSQGQVVARPSSMNHMVAPITGGDIGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPSSLVGLRFGDQVLQINGENCAGWSSDRAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFVFKNGKITSIVKDSSAARNGLLTEHNICEVNGQNVIGLKDSQIADILSTAGNIVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV", "length": 360, "header": "tr|A0AAA9SP21-1|A0AAA9SP21_BOVIN Isoform 1 of Syndecan binding protein OS=Bos taurus OX=9913 GN=SDCBP PE=4 SV=1 CANONICAL=A0AAA9SP21-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21/entry#A0AAA9SP21-1", "sequence": { "sequence": "MGTGSPDRAPRACAGGKRGRCGDARRGRSSGARRPLPSGFQKSEPVTGGGARVSAASKNPAKMSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPVSQDGNLYPKLYPELSQYMGLSLNEEEIRANMALVPGAPSQGQVVARPSSMNHMVAPITGGDIGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPSSLVGLRFGDQVLQINGENCAGWSSDRAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFVFKNGKITSIVKDSSAARNGLLTEHNICEVNGQNVIGLKDSQIADILSTAGNIVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV", "length": 360, "header": "tr|A0AAA9SP21-1|A0AAA9SP21_BOVIN Isoform 1 of Syndecan binding protein OS=Bos taurus OX=9913 GN=SDCBP PE=4 SV=1 CANONICAL=A0AAA9SP21-1" }, "locus": { "chromosome": "14", "start_pos": 24763130, "end_pos": 24729685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103963.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103963.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087121.1" } ] } }, { "isoform_ac": "A0AAA9TDJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21/entry#A0AAA9TDJ4-1", "sequence": { "sequence": "MEKPWKDIPGRRQSFYKDPEAQKHIMLGVKLDEMRPQKSFQKNPAKMSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPVSQDGNLYPKLYPELSQYMGLSLNEEEIRANMALVPGAPSQGVVARPSSMNHMVAPITGGDIGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPSSLVGLRFGDQVLQINGENCAGWSSDRAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFVFKNGKITSIVKDSSAARNGLLTEHNICEVNGQNVIGLKDSQIADILSTAGNIVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV", "length": 343, "header": "tr|A0AAA9TDJ4-1|A0AAA9TDJ4_BOVIN Computationally mapped isoform of Syndecan binding protein OS=Bos taurus OX=9913 GN=SDCBP PE=4 SV=1 CANONICAL=A0AAA9SP21-1" }, "locus": { "chromosome": "14", "start_pos": 24763130, "end_pos": 24743125, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122743.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122743.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094208.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094208.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3HD57-1", "protein_name": "Syntenin-1 isoform X1", "gene_name": "Sdcbp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLYPSLEDLKVDKVIQAQTAFSSGPATQAVLVDVSGAYPTDGNLYPKLYPELSQYMGLTLSEEEICANMPMVSGAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGDNCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDSQIADILSTAGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV", "length": 298 }, "evidence": [ { "id": "A0AAA9SP21", "url": "https://omabrowser.org/oma/group/A0AAA9SP21/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O00560-1", "protein_name": "Syntenin-1", "gene_name": "SDCBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV", "length": 298 }, "evidence": [ { "id": "A0AAA9SP21", "url": "https://omabrowser.org/oma/group/A0AAA9SP21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "regulation of mitotic cell cycle", "id": "GO:0007346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007346", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of phosphorylation", "id": "GO:0042327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042327", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of epithelial to mesenchymal transition", "id": "GO:0010718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010718", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "negative regulation of receptor internalization", "id": "GO:0002091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of exosomal secretion", "id": "GO:1903543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "positive regulation of extracellular exosome assembly", "id": "GO:1903553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903553", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "frizzled binding", "id": "GO:0005109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005109", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "syndecan binding", "id": "GO:0045545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045545", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "interleukin-5 receptor binding", "id": "GO:0005137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005137", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "interleukin-5 receptor complex", "id": "GO:0005895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005895", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SP21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP21" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 255, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP47-1", "uniprot_ac": "A0AAA9SP47", "uniprot_id": "A0AAA9SP47_BOVIN", "mass": { "chemical_mass": 31994.0, "monoisotopic_mass": 31994.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "C2H2-type domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SP47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47", "locus": {} } ], "crossref": [ { "id": "A0AAA9SP47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP47", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SP47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RIARLLESPSVPAVYLSPGLGNPFLPALTPRVSSSLPPPPPDVDTRPAVKEAGPKEEISEDGPSAEGPARHGAGGTKSAYGCSECGKAFGRSSSLTKHRRIHTGEKPFRCDACGKQFLERSSLTIHRRVHTGEKPYACGDCGKAFSQRMNLTVHQRTHTGEKPYACGDCGKAFRKTSSLAQHERVHTGEKPFACGDCGKAFSQSMHLVGHTGEKPYACGECGKAFGQSAYLIEHQRIHTGEKPYRCAQCGKAFIKNSSLTVHQRIHTGEKPYACGECGKTFSRNTNLTRHLRVHV", "length": 295, "header": "tr|A0AAA9SP47-1|A0AAA9SP47_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SP47-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47/entry#A0AAA9SP47-1", "sequence": { "sequence": "RIARLLESPSVPAVYLSPGLGNPFLPALTPRVSSSLPPPPPDVDTRPAVKEAGPKEEISEDGPSAEGPARHGAGGTKSAYGCSECGKAFGRSSSLTKHRRIHTGEKPFRCDACGKQFLERSSLTIHRRVHTGEKPYACGDCGKAFSQRMNLTVHQRTHTGEKPYACGDCGKAFRKTSSLAQHERVHTGEKPFACGDCGKAFSQSMHLVGHTGEKPYACGECGKAFGQSAYLIEHQRIHTGEKPYRCAQCGKAFIKNSSLTVHQRIHTGEKPYACGECGKTFSRNTNLTRHLRVHV", "length": 295, "header": "tr|A0AAA9SP47-1|A0AAA9SP47_BOVIN Isoform 1 of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9SP47-1" }, "locus": { "chromosome": "18", "start_pos": 63848078, "end_pos": 63846565, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089408.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089408.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085755.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SP47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP47" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 107, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 286, "end_pos": 288 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP49-1", "uniprot_ac": "A0AAA9SP49", "uniprot_id": "A0AAA9SP49_BOVIN", "mass": { "chemical_mass": 24004.0, "monoisotopic_mass": 24004.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "60S ribosomal protein L13", "type": "recommended", "evidence": [ { "id": "A0AAA9SP49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49", "locus": {} } ], "crossref": [ { "id": "IPR001380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11722:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11722:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SP49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSLNGMILKPHFHKDWQRRVATWFNQPARKIRRHKARQAKARRIVPRPASGPLRPVVRCLTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDLRQQNKCMESLQANVQQLKEYRSKLILFPRKSSAPKKGDSSAEELKLATQLTGPIMPIRNVCKKEKARVITEEKDFKAFASLHMARANAQLFGIRAKRAKEAAEQDVEKKK", "length": 210, "header": "tr|A0AAA9SP49-1|A0AAA9SP49_BOVIN Isoform 1 of 60S ribosomal protein L13 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SP49-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49/entry#A0AAA9SP49-1", "sequence": { "sequence": "MAPSLNGMILKPHFHKDWQRRVATWFNQPARKIRRHKARQAKARRIVPRPASGPLRPVVRCLTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDLRQQNKCMESLQANVQQLKEYRSKLILFPRKSSAPKKGDSSAEELKLATQLTGPIMPIRNVCKKEKARVITEEKDFKAFASLHMARANAQLFGIRAKRAKEAAEQDVEKKK", "length": 210, "header": "tr|A0AAA9SP49-1|A0AAA9SP49_BOVIN Isoform 1 of 60S ribosomal protein L13 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SP49-1" }, "locus": { "chromosome": "18", "start_pos": 23936259, "end_pos": 23935630, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026123.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026123.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084665.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP57-1", "uniprot_ac": "A0AAA9SP57", "uniprot_id": "A0AAA9SP57_BOVIN", "mass": { "chemical_mass": 115960.0, "monoisotopic_mass": 115960.0 }, "refseq": { "ac": "XP_024856406", "name": "outer dynein arm-docking complex subunit 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856406" }, "gene_names": [ { "name": "ODAD2", "type": "recommended", "evidence": [ { "id": "A0AAA9SP57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57" } ] }, { "name": "ARMC4", "type": "synonym", "evidence": [ { "id": "XP_024856406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856406" } ] }, { "name": "ODAD2", "type": "synonym", "evidence": [ { "id": "XP_024856406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856406" } ] } ], "protein_names": [ { "name": "Outer dynein arm-docking complex subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SP57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57/entry#names_and_taxonomy" } ] }, { "name": "Armadillo repeat-containing protein 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SP57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57/entry#names_and_taxonomy" } ] }, { "name": "outer dynein arm-docking complex subunit 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856406" } ] } ], "function": [ { "annotation": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57#function" }, { "database": "UniProtKB", "id": "ARBA00057400", "url": "https://www.uniprot.org/uniprotkb/ARBA00057400#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ODAD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57", "locus": { "chromosome": "13", "start_pos": 36787921, "end_pos": 36589093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000654", "url": "https://www.ensembl.org/id/ENSBTAG00000000654" } ] } } ], "crossref": [ { "id": "A0AAA9SP57", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP57", "database": "AlphaFoldDB", "categories": [] }, { "id": "526515", "url": "https://www.ncbi.nlm.nih.gov/gene/526515", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46241", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46241", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46241:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46241:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856406", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856406", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH44", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YH44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YH44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVALTRSAQWTAAGHGAKTLEVTPLNEAIVKEIIMFVESFIYKYPQEANYVFVEPLEWKTNLDPSAFGSGYAVSGTTVKSEEADKNGEPLLYLSVPQIKIRSFGQLSRMLYIAKNMKLKEAQACIEANRNPVAKILGLDYNIISEKIGNSFVSNILDKITKDDDSESEIKMKIALQLKQLDLHLLNHSLKHISLEIRLNPGTVKNDIELLKQFSGKGKQTVLESIEYTSDYEFSNGCRAPPWRQIKGEICYVLVKPHDAETLCVTCSKEGVFLNGGKTDDEGQINYERKGEIYKDLVTLLKEKSAIFSENMSKQEIKFSEQPQKDQPNEAPKEEVAITHKASVTSRKSTQEKNRINLGRSQLTKRLEPSLNWRTSVSSKESRNTLRDTQVEKHGGKLEKSRSSVSPGRAQLIRKSVEKIEEIISDSSSESEEDEEQPDHRQEANADLPSEYWQIQKLVKYLKGGNQTATVIALCSMKDFNLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRRNIVDLGGLPVMVNILDSPHKSLKCLAAETIANVAKFRRARRVVRRHGGITKLVALLDCGKHSGEPAQSSLYETRDVEVARCGALALWSCSKSYANKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDEETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQEHENRVIIRRCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIQNAKDAGEMVRSFVGGLELVVNLLKSDNKEVLASVCAVITNIAKDQENLAVITDHGVVPLLSKLANTNNDKLRRHLAETISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCVTMHENGAVKLLLDMVGSPDEELQEAAAGCISNIRRLALAIEKARYS", "length": 1045, "header": "tr|A0AAA9SP57-1|A0AAA9SP57_BOVIN Isoform 1 of Outer dynein arm-docking complex subunit 2 OS=Bos taurus OX=9913 GN=ODAD2 PE=4 SV=1 CANONICAL=A0AAA9SP57-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57/entry#A0AAA9SP57-1", "sequence": { "sequence": "MGVALTRSAQWTAAGHGAKTLEVTPLNEAIVKEIIMFVESFIYKYPQEANYVFVEPLEWKTNLDPSAFGSGYAVSGTTVKSEEADKNGEPLLYLSVPQIKIRSFGQLSRMLYIAKNMKLKEAQACIEANRNPVAKILGLDYNIISEKIGNSFVSNILDKITKDDDSESEIKMKIALQLKQLDLHLLNHSLKHISLEIRLNPGTVKNDIELLKQFSGKGKQTVLESIEYTSDYEFSNGCRAPPWRQIKGEICYVLVKPHDAETLCVTCSKEGVFLNGGKTDDEGQINYERKGEIYKDLVTLLKEKSAIFSENMSKQEIKFSEQPQKDQPNEAPKEEVAITHKASVTSRKSTQEKNRINLGRSQLTKRLEPSLNWRTSVSSKESRNTLRDTQVEKHGGKLEKSRSSVSPGRAQLIRKSVEKIEEIISDSSSESEEDEEQPDHRQEANADLPSEYWQIQKLVKYLKGGNQTATVIALCSMKDFNLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRRNIVDLGGLPVMVNILDSPHKSLKCLAAETIANVAKFRRARRVVRRHGGITKLVALLDCGKHSGEPAQSSLYETRDVEVARCGALALWSCSKSYANKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDEETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQEHENRVIIRRCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIQNAKDAGEMVRSFVGGLELVVNLLKSDNKEVLASVCAVITNIAKDQENLAVITDHGVVPLLSKLANTNNDKLRRHLAETISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCVTMHENGAVKLLLDMVGSPDEELQEAAAGCISNIRRLALAIEKARYS", "length": 1045, "header": "tr|A0AAA9SP57-1|A0AAA9SP57_BOVIN Isoform 1 of Outer dynein arm-docking complex subunit 2 OS=Bos taurus OX=9913 GN=ODAD2 PE=4 SV=1 CANONICAL=A0AAA9SP57-1" }, "locus": { "chromosome": "13", "start_pos": 36754847, "end_pos": 36593248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085682.1" } ] } }, { "isoform_ac": "A0AAF6YH44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57/entry#A0AAF6YH44-1", "sequence": { "sequence": "MGVALTRSAQWTAAGHGAKTLEVTPLNEAIVKEIIMFVESFIYKYPQEANYVFVEPLEWKTNLDPSAFGSGYAVSGTTVKSEEADKNGEPLLYLSVPQIKIRSFGQLSRMLYIAKNMKLKEAQACIEANRNPVAKILGLDYNIISEKIGNSFVSNILDKITKDDDSESEIKMKIALQLKQLDLHLLNHSLKHISLEIRLNPGTVKNDIELLKQFSGKGKQTVLESIEYTSDYEFSNGCRAPPWRQIKGEICYVLVKPHDAETLCVTCSKEGVFLNGGKTDDEGQINYERKGEIYKDLVTLLKEKSAIFSENMSKQEIKFSEQPQKDQPNEAPKEEVAITHKASVTSRKSTQEKNRINLGRSQLTKRLEPSLNWRTSVSSKESRNTLRDTQVEKHGGKLEKSRSSVSPGRAQLIRKSVEKIEEIISDSSSESEEDEEQPDHRQEANADLPSEYWQIQKLVKYLKGGNQTATVIALCSMKDFNLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRRNIVDLGGLPVMVNILDSPHKSLKCLAAETIANVAKFRRARRVVRRHGGITKLVALLDCGKHSGEPAQSSLYETRDVEVARCGALALWSCSKSYANKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAEDEETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQEHENRVIIRRCGGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIQNAKDAGEMVRSFVGGLELVVNLLKSDNKEVLASVCAVITNIAKDQENLAVITDHGVVPLLSKLANTNNDKLRRHLAETISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCVTMHENGAVKVLTQKKRKHMSYKGFVARMLTAIVLEKP", "length": 1036, "header": "tr|A0AAF6YH44-1|A0AAF6YH44_BOVIN Computationally mapped isoform of Outer dynein arm docking complex subunit 2 OS=Bos taurus OX=9913 GN=ODAD2 PE=4 SV=1 CANONICAL=A0AAA9SP57-1" }, "locus": { "chromosome": "13", "start_pos": 36787853, "end_pos": 36593248, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000861.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000861.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000861.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000861.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57" } ], "pmid": "" }, { "name": "ciliary base", "id": "GO:0097546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57" } ], "pmid": "" }, { "name": "outer dynein arm assembly", "id": "GO:0036158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 725, "end_pos": 727, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 817, "end_pos": 819, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 725, "end_pos": 727 }, { "start_pos": 749, "end_pos": 751 }, { "start_pos": 817, "end_pos": 819 }, { "start_pos": 976, "end_pos": 978 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP60-1", "uniprot_ac": "A0AAA9SP60", "uniprot_id": "A0AAA9SP60_BOVIN", "mass": { "chemical_mass": 30304.0, "monoisotopic_mass": 30304.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SP60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60", "locus": {} } ], "crossref": [ { "id": "A0AAA9SP60", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP60", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR033258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15556:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15556:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27924", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27924", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SP60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQQQLRLEREKGAEGERLTKRGRHCLPDSGCSCCVVPQVCPTLLQPHGQAPLSMGFSRQEYRSGLPFSPPGDLPVPGIEPVSPALASRFFTIEPPRKPLPIPGPKHPSAPATSGVQDRPSFTLSTTRPTFSFWGSPAARGWYSGRGQAEPKREARACTGQPEGVREGLTAEAEGSEDTPRPRSLKHPGLATWQNRSFHHPLSILGINYPIAPGRIWELGGGCRQSAEACRAVFDAKYQKNPPRMDFYIFTFTIALIASQVTSSLIEELGCDKFINSK", "length": 277, "header": "tr|A0AAA9SP60-1|A0AAA9SP60_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SP60-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60/entry#A0AAA9SP60-1", "sequence": { "sequence": "MQQQLRLEREKGAEGERLTKRGRHCLPDSGCSCCVVPQVCPTLLQPHGQAPLSMGFSRQEYRSGLPFSPPGDLPVPGIEPVSPALASRFFTIEPPRKPLPIPGPKHPSAPATSGVQDRPSFTLSTTRPTFSFWGSPAARGWYSGRGQAEPKREARACTGQPEGVREGLTAEAEGSEDTPRPRSLKHPGLATWQNRSFHHPLSILGINYPIAPGRIWELGGGCRQSAEACRAVFDAKYQKNPPRMDFYIFTFTIALIASQVTSSLIEELGCDKFINSK", "length": 277, "header": "tr|A0AAA9SP60-1|A0AAA9SP60_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SP60-1" }, "locus": { "chromosome": "11", "start_pos": 675346, "end_pos": 673652, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085687.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085687.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP68-1", "uniprot_ac": "A0AAA9SP68", "uniprot_id": "A0AAA9SP68_BOVIN", "mass": { "chemical_mass": 10740.0, "monoisotopic_mass": 10740.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SP68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68", "locus": {} } ], "crossref": [ { "id": "A0AAA9SP68", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP68", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SP68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QVQLRESGPSLVKPSQTLSLTCTASGFSLSDKAVGWVRQAPGKALEWLGGIDTGGSTGYNPGLKSRLSITKDNSKSQVSLSVSSVTTEDSATYYCTTVHQTQ", "length": 102, "header": "tr|A0AAA9SP68-1|A0AAA9SP68_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SP68-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68/entry#A0AAA9SP68-1", "sequence": { "sequence": "QVQLRESGPSLVKPSQTLSLTCTASGFSLSDKAVGWVRQAPGKALEWLGGIDTGGSTGYNPGLKSRLSITKDNSKSQVSLSVSSVTTEDSATYYCTTVHQTQ", "length": 102, "header": "tr|A0AAA9SP68-1|A0AAA9SP68_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SP68-1" }, "locus": { "chromosome": "21", "start_pos": 274238, "end_pos": 273933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124083.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124083.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084685.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084685.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68" } ], "pmid": "" }, { "name": "immunoglobulin complex", "id": "GO:0019814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SP68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP68" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 102, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SP78-1", "uniprot_ac": "A0AAA9SP78", "uniprot_id": "A0AAA9SP78_BOVIN", "mass": { "chemical_mass": 34577.0, "monoisotopic_mass": 34577.0 }, "refseq": { "ac": "NP_001376735", "name": "olfactory receptor family 8 subfamily A member 1G", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376735" }, "gene_names": [ { "name": "OR8A1G", "type": "recommended", "evidence": [ { "id": "A0AAA9SP78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78" } ] }, { "name": "OR8A1G", "type": "synonym", "evidence": [ { "id": "NP_001376735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376735" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SP78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 8A1", "type": "synonym", "evidence": [ { "id": "NP_001376735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376735" } ] }, { "name": "olfactory receptor family 8 subfamily A member 1G", "type": "synonym", "evidence": [ { "id": "NP_001376735", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376735" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376735" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8A1G", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78", "locus": { "chromosome": "29", "start_pos": 27981410, "end_pos": 27980481, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060371", "url": "https://www.ensembl.org/id/ENSBTAG00000060371" } ] } } ], "crossref": [ { "id": "A0AAA9SP78", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SP78", "database": "AlphaFoldDB", "categories": [] }, { "id": "508589", "url": "https://www.ncbi.nlm.nih.gov/gene/508589", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508589", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508589", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376735", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SP78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATENHSTVTEFILQGLTDRPELQLPLFFLFLGIYLVTMIGNLGVITLICLNAHLHTPMYYFLSNLSFVDLCYSSVITPKMLVNFVSAKNIISYAGCMAQLYFFLVFVIAECYMLTVMAYDRYVAICRPLLYNINMSHQVCSLLVAGVYAIGFIGSTIETGLMLKQSYCEGLISYYFCEILPLMKLTCSSTYHVEMTVFIFAVFNFIVTSSTVLISYAFILSSILCISTTEGRSKAFSTCSSHFAAVGIFYGTTAFMYLKPSTASSLAQENVASVFYTTVIPMLNPLIYSLRNKEVKVAIQKTLRVKSF", "length": 309, "header": "tr|A0AAA9SP78-1|A0AAA9SP78_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8A1G PE=3 SV=1 CANONICAL=A0AAA9SP78-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78/entry#A0AAA9SP78-1", "sequence": { "sequence": "MATENHSTVTEFILQGLTDRPELQLPLFFLFLGIYLVTMIGNLGVITLICLNAHLHTPMYYFLSNLSFVDLCYSSVITPKMLVNFVSAKNIISYAGCMAQLYFFLVFVIAECYMLTVMAYDRYVAICRPLLYNINMSHQVCSLLVAGVYAIGFIGSTIETGLMLKQSYCEGLISYYFCEILPLMKLTCSSTYHVEMTVFIFAVFNFIVTSSTVLISYAFILSSILCISTTEGRSKAFSTCSSHFAAVGIFYGTTAFMYLKPSTASSLAQENVASVFYTTVIPMLNPLIYSLRNKEVKVAIQKTLRVKSF", "length": 309, "header": "tr|A0AAA9SP78-1|A0AAA9SP78_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8A1G PE=3 SV=1 CANONICAL=A0AAA9SP78-1" }, "locus": { "chromosome": "29", "start_pos": 27981407, "end_pos": 27980481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088785.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088785.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084695.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508589", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508589", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SP78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP78" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPE4-1", "uniprot_ac": "A0AAA9SPE4", "uniprot_id": "A0AAA9SPE4_BOVIN", "mass": { "chemical_mass": 15161.0, "monoisotopic_mass": 15161.0 }, "refseq": { "ac": "XP_005213559", "name": "transmembrane protein 210", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213559" }, "gene_names": [ { "name": "TMEM210", "type": "recommended", "evidence": [ { "id": "A0AAA9SPE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4" } ] }, { "name": "TMEM210", "type": "synonym", "evidence": [ { "id": "XP_005213559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213559" } ] } ], "protein_names": [ { "name": "Transmembrane protein 210", "type": "synonym", "evidence": [ { "id": "A0AAA9SPE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 210", "type": "synonym", "evidence": [ { "id": "XP_005213559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213559" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM210", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4", "locus": { "chromosome": "11", "start_pos": 106198184, "end_pos": 106200073, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047964", "url": "https://www.ensembl.org/id/ENSBTAG00000047964" } ] } } ], "crossref": [ { "id": "A0AAA9SPE4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047964", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047964", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101902667", "url": "https://www.ncbi.nlm.nih.gov/gene/101902667", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101902667", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902667", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR39234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39234:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39234:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15195", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15195", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213559", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213559", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZU8", "url": "https://www.uniprot.org/uniprotkb/G3MZU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZU8-1", "url": "https://www.uniprot.org/uniprotkb/G3MZU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAACPQPDSRLLGGPLGLMCLSLLLIPAAAGAYCECSLGLSREALIALLVVLAGISASCFCALVIVAVGVIRAKGETCPAHMDSRMVGHFGVQEDRMDLRTVHVESHLMDPDMAVPMMQPLEEHGLMTITMDPTLEEPPPPPE", "length": 143, "header": "tr|A0AAA9SPE4-1|A0AAA9SPE4_BOVIN Isoform 1 of Transmembrane protein 210 OS=Bos taurus OX=9913 GN=TMEM210 PE=4 SV=1 CANONICAL=A0AAA9SPE4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4/entry#A0AAA9SPE4-1", "sequence": { "sequence": "MAACPQPDSRLLGGPLGLMCLSLLLIPAAAGAYCECSLGLSREALIALLVVLAGISASCFCALVIVAVGVIRAKGETCPAHMDSRMVGHFGVQEDRMDLRTVHVESHLMDPDMAVPMMQPLEEHGLMTITMDPTLEEPPPPPE", "length": 143, "header": "tr|A0AAA9SPE4-1|A0AAA9SPE4_BOVIN Isoform 1 of Transmembrane protein 210 OS=Bos taurus OX=9913 GN=TMEM210 PE=4 SV=1 CANONICAL=A0AAA9SPE4-1" }, "locus": { "chromosome": "11", "start_pos": 106199175, "end_pos": 106198282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098149.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098149.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088165.1" } ] } }, { "isoform_ac": "G3MZU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE4/entry#G3MZU8-1", "sequence": { "sequence": "WAWAHLPQVPLDSARACETQRLKSLPQSSGAEVCQEPPPGSGTVRGSGKSLATRVWLQPPVPWRVRCGTAGAYCECSLGLSREALIALLVVLAGISASCFCALVIVAVGVIRAKGETCPAHMDSRMVGHFGVQEDRMDLRTVHVESHLMDPDMAVPMMQPLEEHGLMTITMDPTLEEPPPPPE", "length": 183, "header": "tr|G3MZU8-1|G3MZU8_BOVIN Computationally mapped isoform of Transmembrane protein 210 OS=Bos taurus OX=9913 GN=TMEM210 PE=4 SV=3 CANONICAL=A0AAA9SPE4-1" }, "locus": { "chromosome": "11", "start_pos": 106200072, "end_pos": 106198282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065269.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065269.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055101.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055101.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101902667", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101902667", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPE8-1", "uniprot_ac": "A0AAA9SPE8", "uniprot_id": "A0AAA9SPE8_BOVIN", "mass": { "chemical_mass": 36636.0, "monoisotopic_mass": 36636.0 }, "refseq": { "ac": "XP_059744902", "name": "zinc finger protein ZIC 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744902" }, "gene_names": [ { "name": "ZIC4", "type": "recommended", "evidence": [ { "id": "A0AAA9SPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ] }, { "name": "ZIC4", "type": "synonym", "evidence": [ { "id": "XP_059744902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744902" } ] } ], "protein_names": [ { "name": "Zic family member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein ZIC 4", "type": "synonym", "evidence": [ { "id": "XP_059744902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744902" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZIC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8", "locus": { "chromosome": "1", "start_pos": 120921569, "end_pos": 120891649, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014749", "url": "https://www.ensembl.org/id/ENSBTAG00000014749" } ] } } ], "crossref": [ { "id": "A0AAA9SPE8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "539312", "url": "https://www.ncbi.nlm.nih.gov/gene/539312", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539312", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539312", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR19818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818:SF167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818:SF167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45718:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45718:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059744902", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744902", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRN8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRN8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSKTSLVMRKRIRLYRNALKEPSSSSGHHGPQLAAASSPSVFPGLHEQPPQASPSGTLNGLLRLGLPGDMYARPEPFPPGPVSRSDALAAAAALHSYGGMNLTMNLAAPHGPGAFFRYMRQPIKQELICKWLAADGPVPPRLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPPSSGYDSATPSALVSPSSDFGREPPVASSAAVAARGADLSE", "length": 335, "header": "tr|A0AAA9SPE8-1|A0AAA9SPE8_BOVIN Isoform 1 of Zic family member 4 OS=Bos taurus OX=9913 GN=ZIC4 PE=3 SV=1 CANONICAL=A0AAA9SPE8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8/entry#A0AAA9SPE8-1", "sequence": { "sequence": "MRSKTSLVMRKRIRLYRNALKEPSSSSGHHGPQLAAASSPSVFPGLHEQPPQASPSGTLNGLLRLGLPGDMYARPEPFPPGPVSRSDALAAAAALHSYGGMNLTMNLAAPHGPGAFFRYMRQPIKQELICKWLAADGPVPPRLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPPSSGYDSATPSALVSPSSDFGREPPVASSAAVAARGADLSE", "length": 335, "header": "tr|A0AAA9SPE8-1|A0AAA9SPE8_BOVIN Isoform 1 of Zic family member 4 OS=Bos taurus OX=9913 GN=ZIC4 PE=3 SV=1 CANONICAL=A0AAA9SPE8-1" }, "locus": { "chromosome": "1", "start_pos": 120919340, "end_pos": 120907831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106604.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106604.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084785.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084785.1" } ] } }, { "isoform_ac": "A0ABI0NRN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8/entry#A0ABI0NRN8-1", "sequence": { "sequence": "MRSKTSLVMRKRIRLYRNALKEPREKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPPSSGYDSATPSALVSPSSDFGREPPVASSAAVAARGADLSE", "length": 129, "header": "tr|A0ABI0NRN8-1|A0ABI0NRN8_BOVIN Computationally mapped isoform of Zic family member 4 OS=Bos taurus OX=9913 GN=ZIC4 PE=4 SV=1 CANONICAL=A0AAA9SPE8-1" }, "locus": { "chromosome": "1", "start_pos": 120919340, "end_pos": 120907831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144244.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144244.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105317.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105317.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 303, "start_aa": "Thr", "end_pos": 303, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr303", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539312", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539312", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPE8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 203, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 303 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 247, "end_pos": 249 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPF4-1", "uniprot_ac": "A0AAA9SPF4", "uniprot_id": "A0AAA9SPF4_BOVIN", "mass": { "chemical_mass": 131497.0, "monoisotopic_mass": 131497.0 }, "refseq": { "ac": "XP_024854363", "name": "apical endosomal glycoprotein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854363" }, "gene_names": [ { "name": "MAMDC4", "type": "recommended", "evidence": [ { "id": "A0AAA9SPF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4" } ] }, { "name": "MAMDC4", "type": "synonym", "evidence": [ { "id": "XP_024854363", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854363" } ] } ], "protein_names": [ { "name": "MAM domain containing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SPF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4/entry#names_and_taxonomy" } ] }, { "name": "apical endosomal glycoprotein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024854363", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854363" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAMDC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4", "locus": { "chromosome": "11", "start_pos": 105947549, "end_pos": 105939436, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021550", "url": "https://www.ensembl.org/id/ENSBTAG00000021550" } ] } } ], "crossref": [ { "id": "A0AAA9SPF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515379", "url": "https://www.ncbi.nlm.nih.gov/gene/515379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051560", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051560", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23282:SF129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23282:SF129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00629", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00629", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024854363", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854363", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLHGHLLPAVVMLLAGSPGWAWVPNHCRTPREAVCNFVCDCRGCPDEAQCGYHGTSPSLGTPFTCDFERDSCGWRDISTAGYRWLRDRAGASPERPGLRADHTLGTDLGWYVAVGTHRGRETATAALRSPVLHEAAPTCELRLWYHVASGDVAELRLELTHGVETLTLWQSAGPWDPDWQELAVPTGRIRGAFRVTFSATRNATHRGTVALDDVAFWRCGLPTPQAHCPRGHHRCQNEACVEPAQLCDGEDNCGDHSDEDAAPCRHYIATDFEMGLGLWNHSEGWTRNHSAGGPRYPAWPRGDHTWNSAQGSFLASVAEPSTPAVLSSPEFQASAPHNCSLVFYHYLHGSEAGCLQVFLQTASPAAPQTPVLLRRRHGELGAAWVRDRVDIQSEHPFRILLAGQTGPGGVVGLDDLILSNHCKPIPELAGPPPGCWAPGPWPQPPSLRPRSFCEPGHFFCGDLCVPPEQLCDFQQQCPGGEDEQECGTTDFESLSGGGWEDASVGRLQWVRLPAPDRGMPSPDAHGAAGHFLAVQRAWGQLAEEARALTPTLGPSGPRCELRLVYYLQSHPRGFLELLVVEGSRRELVWQALGTTAGGWKVDRVLLGARRRPFRLELVGLVDLDGPGQQGAGVDDVTLTGCSPTAAAEEDSEVSCNFERGACGWHTGHLTDAHWHRVESRGPRYDHTTGQGHFVLLDPVDPPARGPAAHLLTQPRVPSAPQECLSFWFHLFGPQIGTLRLAMRREGEAETHLWSRSGTHGNCWHEAWATLHHQPDSGAKYQLLFEGLRDGYHGSMALDDVTLRPGPCWAPRRCSFEDSACGFSVGGRGLWTRQANASWGPHADHTTETAQGHYMVVDMSPQALPRGHAALLTSEEQRPLVQPTCLTFWYHLSLRNPGTLRVHVEEAGRQQVLSVSSRGGAAWRLGSVDLQAGQAWRVVFEAVAAGVEHSYVALDDLLLQDGPCPLPASCDFEAGLCGWNHVPRPGLGGYSWDWSSGASPSRYPQPPVDHTLGTEAGHFALFETSVLGPGGRAAGLISQPLPPTTASCLRFWYHMGFPEHFYQGELRVLLSSAQGQLAVWGAGGRHRHQWLEGQVDVASAREFQIVFEATLGGQPALGPIALDDVEYLAGQRCQLSTPSQGDGAAAAVVPAAVGGTLLLLVLLMLLGVAGRRWLQKGGCPSWGKADTVTPGFDNILFSADRVTLPASVPHDQ", "length": 1212, "header": "tr|A0AAA9SPF4-1|A0AAA9SPF4_BOVIN Isoform 1 of MAM domain containing 4 OS=Bos taurus OX=9913 GN=MAMDC4 PE=4 SV=1 CANONICAL=A0AAA9SPF4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4/entry#A0AAA9SPF4-1", "sequence": { "sequence": "MPLHGHLLPAVVMLLAGSPGWAWVPNHCRTPREAVCNFVCDCRGCPDEAQCGYHGTSPSLGTPFTCDFERDSCGWRDISTAGYRWLRDRAGASPERPGLRADHTLGTDLGWYVAVGTHRGRETATAALRSPVLHEAAPTCELRLWYHVASGDVAELRLELTHGVETLTLWQSAGPWDPDWQELAVPTGRIRGAFRVTFSATRNATHRGTVALDDVAFWRCGLPTPQAHCPRGHHRCQNEACVEPAQLCDGEDNCGDHSDEDAAPCRHYIATDFEMGLGLWNHSEGWTRNHSAGGPRYPAWPRGDHTWNSAQGSFLASVAEPSTPAVLSSPEFQASAPHNCSLVFYHYLHGSEAGCLQVFLQTASPAAPQTPVLLRRRHGELGAAWVRDRVDIQSEHPFRILLAGQTGPGGVVGLDDLILSNHCKPIPELAGPPPGCWAPGPWPQPPSLRPRSFCEPGHFFCGDLCVPPEQLCDFQQQCPGGEDEQECGTTDFESLSGGGWEDASVGRLQWVRLPAPDRGMPSPDAHGAAGHFLAVQRAWGQLAEEARALTPTLGPSGPRCELRLVYYLQSHPRGFLELLVVEGSRRELVWQALGTTAGGWKVDRVLLGARRRPFRLELVGLVDLDGPGQQGAGVDDVTLTGCSPTAAAEEDSEVSCNFERGACGWHTGHLTDAHWHRVESRGPRYDHTTGQGHFVLLDPVDPPARGPAAHLLTQPRVPSAPQECLSFWFHLFGPQIGTLRLAMRREGEAETHLWSRSGTHGNCWHEAWATLHHQPDSGAKYQLLFEGLRDGYHGSMALDDVTLRPGPCWAPRRCSFEDSACGFSVGGRGLWTRQANASWGPHADHTTETAQGHYMVVDMSPQALPRGHAALLTSEEQRPLVQPTCLTFWYHLSLRNPGTLRVHVEEAGRQQVLSVSSRGGAAWRLGSVDLQAGQAWRVVFEAVAAGVEHSYVALDDLLLQDGPCPLPASCDFEAGLCGWNHVPRPGLGGYSWDWSSGASPSRYPQPPVDHTLGTEAGHFALFETSVLGPGGRAAGLISQPLPPTTASCLRFWYHMGFPEHFYQGELRVLLSSAQGQLAVWGAGGRHRHQWLEGQVDVASAREFQIVFEATLGGQPALGPIALDDVEYLAGQRCQLSTPSQGDGAAAAVVPAAVGGTLLLLVLLMLLGVAGRRWLQKGGCPSWGKADTVTPGFDNILFSADRVTLPASVPHDQ", "length": 1212, "header": "tr|A0AAA9SPF4-1|A0AAA9SPF4_BOVIN Isoform 1 of MAM domain containing 4 OS=Bos taurus OX=9913 GN=MAMDC4 PE=4 SV=1 CANONICAL=A0AAA9SPF4-1" }, "locus": { "chromosome": "11", "start_pos": 105947118, "end_pos": 105939635, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032582.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032582.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085880.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085880.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1189, "start_aa": "Thr", "end_pos": 1189, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1189", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 323, "start_aa": "Thr", "end_pos": 323, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr323", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 645, "start_aa": "Thr", "end_pos": 645, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr645", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 836, "end_pos": 838, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF4" }, { "id": "PS50060", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50060" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAM", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 222, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 323, 645, 1189 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 281, "end_pos": 283 }, { "start_pos": 289, "end_pos": 291 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 836, "end_pos": 838 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPF6-1", "uniprot_ac": "A0AAA9SPF6", "uniprot_id": "A0AAA9SPF6_BOVIN", "mass": { "chemical_mass": 51560.0, "monoisotopic_mass": 51560.0 }, "refseq": { "ac": "NP_001071572", "name": "uncharacterized protein LOC768229", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071572" }, "gene_names": [ { "name": "LOC768229", "type": "recommended", "evidence": [ { "id": "A0AAA9SPF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6" } ] }, { "name": "LOC768229", "type": "synonym", "evidence": [ { "id": "NP_001071572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071572" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain containing 5B", "type": "recommended", "evidence": [ { "id": "A0AAA9SPF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein LOC768229", "type": "synonym", "evidence": [ { "id": "NP_001071572", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071572" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC768229", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6", "locus": {} } ], "crossref": [ { "id": "A0AAA9SPF6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768229", "url": "https://www.ncbi.nlm.nih.gov/gene/768229", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768229", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768229", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF306", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF306", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071572", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENQTRGRGRFADIPGAGSPASAPCQDTRRENPDSDLEKLRICFRTFSSSDESDPIKALRRLRELCSLWLRPDLHTKEEMVDRLVLEQFVMCMPPDIQVLVKSSGAETCKDLEELLRKKQKLQKWAGVRVQGEDFLMPVSGVEMLGSEVSEGHGEGDRAREPQSTVSVVPPDEGQPESQDGQHLPGAKDLLMGQGQKALPPETIPETGELECQTPSKEYLVKDLLEDTGVTRTLPSQEPELLQNHEGDVSTPSGSRRGPLKNHRHVKRKRDSTPTCQDVGQESATCLDQGEFSGQLGSHSVGAFGSMGPTSHSEGAGTPGRARSECKVCKKSFPYQYQLTVHQRTHTGERPFQCDICAKGFIQPSDLRVHQRIHTGEKPYSCDICLKKFTHNSTMHAHKVTHSQEKPFRCEHCDRAFAYRANLTVHRRTHSGLKPYVCPECHRAFSQLGSFKRHRKIHSR", "length": 461, "header": "tr|A0AAA9SPF6-1|A0AAA9SPF6_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC768229 PE=3 SV=2 CANONICAL=A0AAA9SPF6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6/entry#A0AAA9SPF6-1", "sequence": { "sequence": "MAENQTRGRGRFADIPGAGSPASAPCQDTRRENPDSDLEKLRICFRTFSSSDESDPIKALRRLRELCSLWLRPDLHTKEEMVDRLVLEQFVMCMPPDIQVLVKSSGAETCKDLEELLRKKQKLQKWAGVRVQGEDFLMPVSGVEMLGSEVSEGHGEGDRAREPQSTVSVVPPDEGQPESQDGQHLPGAKDLLMGQGQKALPPETIPETGELECQTPSKEYLVKDLLEDTGVTRTLPSQEPELLQNHEGDVSTPSGSRRGPLKNHRHVKRKRDSTPTCQDVGQESATCLDQGEFSGQLGSHSVGAFGSMGPTSHSEGAGTPGRARSECKVCKKSFPYQYQLTVHQRTHTGERPFQCDICAKGFIQPSDLRVHQRIHTGEKPYSCDICLKKFTHNSTMHAHKVTHSQEKPFRCEHCDRAFAYRANLTVHRRTHSGLKPYVCPECHRAFSQLGSFKRHRKIHSR", "length": 461, "header": "tr|A0AAA9SPF6-1|A0AAA9SPF6_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 5B OS=Bos taurus OX=9913 GN=LOC768229 PE=3 SV=2 CANONICAL=A0AAA9SPF6-1" }, "locus": { "chromosome": "18", "start_pos": 63612174, "end_pos": 63609196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118249.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118249.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085815.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085815.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768229", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768229", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 325, "end_pos": 352, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SPF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF6" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 122, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 393, "end_pos": 395 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPG2-1", "uniprot_ac": "A0AAA9SPG2", "uniprot_id": "A0AAA9SPG2_BOVIN", "mass": { "chemical_mass": 78519.0, "monoisotopic_mass": 78519.0 }, "refseq": { "ac": "XP_024856010", "name": "transcriptional repressor CTCFL isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856010" }, "gene_names": [ { "name": "CTCFL", "type": "recommended", "evidence": [ { "id": "A0AAA9SPG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ] }, { "name": "BORIS", "type": "synonym", "evidence": [ { "id": "XP_024856010", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856010" } ] }, { "name": "CTCFL", "type": "synonym", "evidence": [ { "id": "XP_024856010", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856010" } ] } ], "protein_names": [ { "name": "CCCTC-binding factor", "type": "recommended", "evidence": [ { "id": "A0AAA9SPG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2/entry#names_and_taxonomy" } ] }, { "name": "transcriptional repressor CTCFL isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856010", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856010" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTCFL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2", "locus": { "chromosome": "13", "start_pos": 58682600, "end_pos": 58657477, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013079", "url": "https://www.ensembl.org/id/ENSBTAG00000013079" } ] } } ], "crossref": [ { "id": "A0AAA9SPG2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPG2", "database": "AlphaFoldDB", "categories": [] }, { "id": "100144618", "url": "https://www.ncbi.nlm.nih.gov/gene/100144618", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856010", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856010", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQHEADSSGLGGRRVQATLLGGGVIMAGAELSVPPEQFTQIKEPELIPDRALEEEKEEENDNDGVRRVKEQSGSAGLEVESAQGPFQTTILEEVPELVLAAPEEIERHLLTLQTVHFPSEEAELQDLSWLDPQQEDEMQVRVRQAGSGVQSLVWLEEAAQQSLHQCVLNVQEEVYSLQQMEVMQFQLLEENVTGAVEDCKSAVSLEESTGSIKLQKGQEEEQLLTEGGFSEKAEEQFFLVEARPGDEGRDEIVLTFSNLNMEEQKEKPELSQAHLEKPSTTKNRNKAKEVKQTFHCNFCKFTSSRISSVNRHMKIHSTEKPHVCHLCLKAFRTVTLLRNHVNTHTGTRPHKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFQCSLCSYASKDTYKLKRHMRTHSGEKPYECHICRARFTQSGTMKMHILQKHSENVPKYQCPHCATVIARKSDLRVHLRNLHTYKAAEMKCRYCPAVFHDRYTLIQHQKTHKNEKKFKCGYCSYVCKQERHMTVHIRTHTGEKPFICLACTKCFRQQQLLNVHSKKQHNINFVPTVYECPKCGKGFSRWGNMHRHSKKCNSGQETPTPVEKERATKRKPASPREPAKEDEAAAKEVSLVSGELYPGEMVPIDFLEAKTGGEDLEQDLEQDLTCDMILALMNK", "length": 688, "header": "tr|A0AAA9SPG2-1|A0AAA9SPG2_BOVIN Isoform 1 of CCCTC-binding factor OS=Bos taurus OX=9913 GN=CTCFL PE=3 SV=1 CANONICAL=A0AAA9SPG2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2/entry#A0AAA9SPG2-1", "sequence": { "sequence": "MQHEADSSGLGGRRVQATLLGGGVIMAGAELSVPPEQFTQIKEPELIPDRALEEEKEEENDNDGVRRVKEQSGSAGLEVESAQGPFQTTILEEVPELVLAAPEEIERHLLTLQTVHFPSEEAELQDLSWLDPQQEDEMQVRVRQAGSGVQSLVWLEEAAQQSLHQCVLNVQEEVYSLQQMEVMQFQLLEENVTGAVEDCKSAVSLEESTGSIKLQKGQEEEQLLTEGGFSEKAEEQFFLVEARPGDEGRDEIVLTFSNLNMEEQKEKPELSQAHLEKPSTTKNRNKAKEVKQTFHCNFCKFTSSRISSVNRHMKIHSTEKPHVCHLCLKAFRTVTLLRNHVNTHTGTRPHKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFQCSLCSYASKDTYKLKRHMRTHSGEKPYECHICRARFTQSGTMKMHILQKHSENVPKYQCPHCATVIARKSDLRVHLRNLHTYKAAEMKCRYCPAVFHDRYTLIQHQKTHKNEKKFKCGYCSYVCKQERHMTVHIRTHTGEKPFICLACTKCFRQQQLLNVHSKKQHNINFVPTVYECPKCGKGFSRWGNMHRHSKKCNSGQETPTPVEKERATKRKPASPREPAKEDEAAAKEVSLVSGELYPGEMVPIDFLEAKTGGEDLEQDLEQDLTCDMILALMNK", "length": 688, "header": "tr|A0AAA9SPG2-1|A0AAA9SPG2_BOVIN Isoform 1 of CCCTC-binding factor OS=Bos taurus OX=9913 GN=CTCFL PE=3 SV=1 CANONICAL=A0AAA9SPG2-1" }, "locus": { "chromosome": "13", "start_pos": 58681303, "end_pos": 58657676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126164.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126164.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087239.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087239.1" } ] } }, { "isoform_ac": "A0AAA9TC45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2/entry#A0AAA9TC45-1", "sequence": { "sequence": "MAGAELSVPPEQFTQIKEPELIPDRALEEEKEEENDNDGVRRVKEQSGSAGLEVESAQGPFQTTILEEVPELVLAAPEEIERHLLTLQTVHFPSEEAELQDLSWLDPQQEDEMQEEVYSLQQMEVMQFQLLEENVTGAVEDCKSAVSLEESTGSIKLQKGQEEEQLLTEGGFSEKAEEQFFLVEARPGDEGRDEIVLTFSNLNMEEQKEKPELSQAHLEKPSTTKNRNKAKEVKQTFHCNFCKFTSSRISSVNRHMKIHSTEKPHVCHLCLKAFRTVTLLRNHVNTHTGTRPHKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFQCSLCSYASKDTYKLKRHMRTHSGEKPYECHICRARFTQSGTMKMHILQKHSENVPKYQCPHCATVIARKSDLRVHLRNLHTYKAAEMKCRYCPAVFHDRYTLIQHQKTHKNEKKFKCGYCSYVCKQERHMTVHIRTHTGEKPFICLACTKCFRQQQLLNVHSKKQHNINFVPTVYECPKCGKGFSRWMLY", "length": 541, "header": "tr|A0AAA9TC45-1|A0AAA9TC45_BOVIN Computationally mapped isoform of CCCTC-binding factor OS=Bos taurus OX=9913 GN=CTCFL PE=3 SV=1 CANONICAL=A0AAA9SPG2-1" }, "locus": { "chromosome": "13", "start_pos": 58672850, "end_pos": 58658394, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094742.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094742.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095622.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095622.1" } ] } }, { "isoform_ac": "A0AAF6DLJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2/entry#A0AAF6DLJ0-1", "sequence": { "sequence": "MQHEADSSGLGGRRVQATLLGGGVIMAGAELSVPPEQFTQIKEPELIPDRALEEEKEEENDNDGVRRVKEQSGSAGLEVESAQGPFQTTILEEVPELVLAAPEEIERHLLTLQTVHFPSEEAELQDLSWLDPQQEDEMQEEVYSLQQMEVMQFQLLEENVTGAVEDCKSAVSLEESTGSIKLQKGQEEEQLLTEGGFSEKAEEQFFLVEARPGDEGRDEIVLTFSNLNMEEQKEKPELSQAHLEKPSTTKNRNKAKEVKQTFHCNFCKFTSSRISSVNRHMKIHSTEKPHVCHLCLKAFRTVTLLRNHVNTHTGTRPHKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFQCSLCSYASKDTYKLKRHMRTHSGEKPYECHICRARFTQSGTMKMHILQKHSENVPKYQCPHCATVIARKSDLRVHLRNLHTYKAAEMKCRYCPAVFHDRYTLIQHQKTHKNEKKFKCGYCSYVCKQERHMTVHIRTHTGEKPFICLACTKCFRQQQLLNVHSKKQHNINFVPTVYECPKCGKGFSRWGNMHRHSKKCNSGQETPTPVEKERATKRKPASPREPAKEDEAAAKEVSLVSGELYPGEMVPIDFLEAKTGGEDLEQDLEQDLTCDMILALMNK", "length": 656, "header": "tr|A0AAF6DLJ0-1|A0AAF6DLJ0_BOVIN Computationally mapped isoform of CCCTC-binding factor OS=Bos taurus OX=9913 GN=CTCFL PE=3 SV=1 CANONICAL=A0AAA9SPG2-1" }, "locus": { "chromosome": "13", "start_pos": 58681303, "end_pos": 58657676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017390.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017390.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017390.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017390.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "transcription initiation-coupled chromatin remodeling", "id": "GO:0045815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "genomic imprinting", "id": "GO:0071514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "establishment of protein localization to chromatin", "id": "GO:0071169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071169", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPG2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 294, "end_pos": 321, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPJ1-1", "uniprot_ac": "A0AAA9SPJ1", "uniprot_id": "A0AAA9SPJ1_BOVIN", "mass": { "chemical_mass": 13560.0, "monoisotopic_mass": 13560.0 }, "refseq": {}, "gene_names": [ { "name": "C18H19orf33", "type": "recommended", "evidence": [ { "id": "A0AAA9SPJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1" } ] } ], "protein_names": [ { "name": "Chromosome 18 C19orf33 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SPJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C18H19orf33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SPJ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "787634", "url": "https://www.ncbi.nlm.nih.gov/gene/787634", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787634", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787634", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PF15761", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15761", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFDLSAAVESTSKKPQGAGKVGDPKHSSPKVQGGSADNLKHHHGHGHGQGSASDSSSSSSDSENEAKVRGFPLCSGCPAPQVRAESQPGTRAEDSPAEPSLPSYPHHPRPHSPARSSTRAPQARSRNPR", "length": 130, "header": "tr|A0AAA9SPJ1-1|A0AAA9SPJ1_BOVIN Isoform 1 of Chromosome 18 C19orf33 homolog OS=Bos taurus OX=9913 GN=C18H19orf33 PE=1 SV=1 CANONICAL=A0AAA9SPJ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1/entry#A0AAA9SPJ1-1", "sequence": { "sequence": "MEFDLSAAVESTSKKPQGAGKVGDPKHSSPKVQGGSADNLKHHHGHGHGQGSASDSSSSSSDSENEAKVRGFPLCSGCPAPQVRAESQPGTRAEDSPAEPSLPSYPHHPRPHSPARSSTRAPQARSRNPR", "length": 130, "header": "tr|A0AAA9SPJ1-1|A0AAA9SPJ1_BOVIN Isoform 1 of Chromosome 18 C19orf33 homolog OS=Bos taurus OX=9913 GN=C18H19orf33 PE=1 SV=1 CANONICAL=A0AAA9SPJ1-1" }, "locus": { "chromosome": "18", "start_pos": 48119797, "end_pos": 48119157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105289.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105289.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087270.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087270.1" } ] } }, { "isoform_ac": "A0AAA9TNQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1/entry#A0AAA9TNQ7-1", "sequence": { "sequence": "MEFDLSAAVESTSKKPQGAGKVGDPKHSSPKVQGGSADNLKHHHGHGHGQGSASDSSSSSSDSENEAKSGSEQHKSASGKVKKPKVKKEKKKKEEGKKKASH", "length": 102, "header": "tr|A0AAA9TNQ7-1|A0AAA9TNQ7_BOVIN Computationally mapped isoform of Chromosome 18 C19orf33 homolog OS=Bos taurus OX=9913 GN=C18H19orf33 PE=1 SV=2 CANONICAL=A0AAA9SPJ1-1" }, "locus": { "chromosome": "18", "start_pos": 48119847, "end_pos": 48119157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097970.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097970.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787634", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787634", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPJ5-1", "uniprot_ac": "A0AAA9SPJ5", "uniprot_id": "A0AAA9SPJ5_BOVIN", "mass": { "chemical_mass": 232095.0, "monoisotopic_mass": 232095.0 }, "refseq": {}, "gene_names": [ { "name": "ICE1", "type": "recommended", "evidence": [ { "id": "A0AAA9SPJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ] } ], "protein_names": [ { "name": "Interactor of little elongation complex ELL subunit 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SPJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ICE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5", "locus": { "chromosome": "20", "start_pos": 67652369, "end_pos": 67716834, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018501", "url": "https://www.ensembl.org/id/ENSBTAG00000018501" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018501", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018501", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR057881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MS14", "url": "https://www.orthodb.org/?gene=F1MS14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11852", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11852", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11852:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11852:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25817", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25817", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS14", "url": "https://www.uniprot.org/uniprotkb/F1MS14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS14-1", "url": "https://www.uniprot.org/uniprotkb/F1MS14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVDALITLKQKIINTDNLLTEYQKKFLQLQFARRENSTLHHQVEQMLQKISPLQKCQEELGFLKAELEEKKSSLKLYQDTHQEYARVKEECLKTDAQKKKLEAKVKKLEEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNERELRHIGTQISSDSYGSIDKRKVKLLLKELWLCINTTHRLPGEGGRYIPEKPAREYCRSIEFGEDGVPPAAGGSPIRTSAVQTCLAELSMEIEGDFSACEDVGGAAGRDNGLSQEDTSPKAVAWRSEAQGPGFDEDLQAAVDFFRLPPPLLSPVPSPPLASPPHLGVSPSLFAPEPFGEGANSSDYESAPCRNSEPVSKEDPPEAQDRCGLSGEKKGAGAWEEQPHTREAALALSAGTTLGFGTFAANLQEPAASFAFAREQLWTVSSELGSGREKGVVDKLGRHREVGQKDRLVPTVWTRPRAPGGKPAETLLGGLAREEGTAHGQSDPRPPPLGLQPLREPRAPDGKTLLSPWIESPKLELARWTLIDGTASESGRQSASGHFQGQPRALEKERGATQGCVSEGPPTPGTAGLSLGDAWSCSSASGASPCCGHPPSPSGLEDGGGPAIPPAVGPPRPCGSEQTTPAAGVTAVEVPPEPPGCSSGGARLESSFPTLCPMSGTSDPFGQRSGPLGCAAFVKDLSDACLLPQPPFPSRSSFPPRSAFPGAAGIGLAAGQALRVELAPARTGFRASPGPLSSLVRSGFGFGRSASWHHSDLLRRGSEARPRAVWSSEGGGSACVFTSEDRGPAAPRAPTSVLPNQVSVITRQARPGPAQPARPETPAPHGDARASWLACGAQHGGERRDTKSSARSPASGAPASWGRLDFDAPSGSFPVENSHHPTDCKSSFFSENIPVPNRDAVMGAAVQEEAQKQSPGLLATGVDTASLDVDKCPDTDLTLSGGFPAGDAVRCPGAALAVSQAPPALQRGLKERLLLESESPGCAPLEGLGAAETASPRPAPCCYSGIREAGGGDTEVEESEAPSSSEGEPEPDPALEPDLHSAPRARGWGAGPAEAGPSVEVGSLTSALQDFNISTLSEMDRLSTSEVVMFLESCQLRDYSSADSVSECSSKGTLNRGMKEELKPSGPSGEGYGSQLCEEEALETSEEWVESEEDDCTLRGQLPRCSLETLSEVLTRLGQELQASQEDSEAEEAEGLLLFRGPESATAEHLQQQLPPLDTAITASPTPRASAHTQGGSPTCAEPGRENTQSTPEGRVDAVRPAGNREEIQSEPEEPSVPNADPGAGPGEVRLQCQISTVTSEVINVLINKDQNLVIEKGDNWTIINGVTLMPELGQVILCDAPEAAPLSTHSEELAAGFLLVPPVERSPEAGRPGSPLQEPPCGRSAAGTQEDISSSGQSGNFDKSRLRNRPVKPSVRISSEIYDQNFESQAAPFDHTYCNSKLEPLGKNKNRSKVSNRDQSNKPVRTPASGRVETIEREVSPSFSGDRGHGRPQRSHTHTILATADTSTPADCCVDTLSKIRQEVGPPLPPLLAPLIATPPRTSRLASPLISSSSPSSPLSPLCPTSPSSEPPAPPVTSPLPEEPRPCSPLCASPSPSSAPAGNRVLSSPLQFCAATPKHALPVPGRLPPLAPAHPAVAAPPENSVKILDTMYPELSARARTLNILKGNIQLTRGPPANRKGLPGPVGALAGFQAIASSSTAFVKAGGSSGSDGKQDKVGGLGPPQDPAGKRTLSASAPRSAKRLRLDNGSPEPEPTPEGMGCSPWTDLPQAAAPSTEDNRHPLPASQSPSSPEETADSPDRAITEALRKIGEATFDLLPVIRSHVYVGNVSTKPVMRDQEKDVVYEFSTTKKHLAESLLHSILSELKSQKMSVEHNYIHALCRVYVGVCRQLGDLERARLFCYGLLKEDFPESEKLTLFIANMWHDVFISQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQPSVRFGEDLSDSTWEYVCAIDLLCCHQKWVWTHDNIISKELWPVMDKWIKYRKGHANVAYTPDIIVASVLRLIGRLGQLGLKEGFPSAVKNISTVIGMFIQHAQDEDIPWGVQLAAVYALCDLSPSNPAEISKILEAWRRETARSVPAAVLGALDEVGALCAEGRG", "length": 2178, "header": "tr|A0AAA9SPJ5-1|A0AAA9SPJ5_BOVIN Isoform 1 of Interactor of little elongation complex ELL subunit 1 OS=Bos taurus OX=9913 GN=ICE1 PE=4 SV=1 CANONICAL=A0AAA9SPJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5/entry#A0AAA9SPJ5-1", "sequence": { "sequence": "MMPGETHSAAPGTAADLSRCQGCASLQQNLNEYVDALITLKQKIINTDNLLTEYQKKFLQLQFARRENSTLHHQVEQMLQKISPLQKCQEELGFLKAELEEKKSSLKLYQDTHQEYARVKEECLKTDAQKKKLEAKVKKLEEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNERELRHIGTQISSDSYGSIDKRKVKLLLKELWLCINTTHRLPGEGGRYIPEKPAREYCRSIEFGEDGVPPAAGGSPIRTSAVQTCLAELSMEIEGDFSACEDVGGAAGRDNGLSQEDTSPKAVAWRSEAQGPGFDEDLQAAVDFFRLPPPLLSPVPSPPLASPPHLGVSPSLFAPEPFGEGANSSDYESAPCRNSEPVSKEDPPEAQDRCGLSGEKKGAGAWEEQPHTREAALALSAGTTLGFGTFAANLQEPAASFAFAREQLWTVSSELGSGREKGVVDKLGRHREVGQKDRLVPTVWTRPRAPGGKPAETLLGGLAREEGTAHGQSDPRPPPLGLQPLREPRAPDGKTLLSPWIESPKLELARWTLIDGTASESGRQSASGHFQGQPRALEKERGATQGCVSEGPPTPGTAGLSLGDAWSCSSASGASPCCGHPPSPSGLEDGGGPAIPPAVGPPRPCGSEQTTPAAGVTAVEVPPEPPGCSSGGARLESSFPTLCPMSGTSDPFGQRSGPLGCAAFVKDLSDACLLPQPPFPSRSSFPPRSAFPGAAGIGLAAGQALRVELAPARTGFRASPGPLSSLVRSGFGFGRSASWHHSDLLRRGSEARPRAVWSSEGGGSACVFTSEDRGPAAPRAPTSVLPNQVSVITRQARPGPAQPARPETPAPHGDARASWLACGAQHGGERRDTKSSARSPASGAPASWGRLDFDAPSGSFPVENSHHPTDCKSSFFSENIPVPNRDAVMGAAVQEEAQKQSPGLLATGVDTASLDVDKCPDTDLTLSGGFPAGDAVRCPGAALAVSQAPPALQRGLKERLLLESESPGCAPLEGLGAAETASPRPAPCCYSGIREAGGGDTEVEESEAPSSSEGEPEPDPALEPDLHSAPRARGWGAGPAEAGPSVEVGSLTSALQDFNISTLSEMDRLSTSEVVMFLESCQLRDYSSADSVSECSSKGTLNRGMKEELKPSGPSGEGYGSQLCEEEALETSEEWVESEEDDCTLRGQLPRCSLETLSEVLTRLGQELQASQEDSEAEEAEGLLLFRGPESATAEHLQQQLPPLDTAITASPTPRASAHTQGGSPTCAEPGRENTQSTPEGRVDAVRPAGNREEIQSEPEEPSVPNADPGAGPGEVRLQCQISTVTSEVINVLINKDQNLVIEKGDNWTIINGVTLMPELGQVILCDAPEAAPLSTHSEELAAGFLLVPPVERSPEAGRPGSPLQEPPCGRSAAGTQEDISSSGQSGNFDKSRLRNRPVKPSVRISSEIYDQNFESQAAPFDHTYCNSKLEPLGKNKNRSKVSNRDQSNKPVRTPASGRVETIEREVSPSFSGDRGHGRPQRSHTHTILATADTSTPADCCVDTLSKIRQEVGPPLPPLLAPLIATPPRTSRLASPLISSSSPSSPLSPLCPTSPSSEPPAPPVTSPLPEEPRPCSPLCASPSPSSAPAGNRVLSSPLQFCAATPKHALPVPGRLPPLAPAHPAVAAPPENSVKILDTMYPELSARARTLNILKGNIQLTRGPPANRKGLPGPVGALAGFQAIASSSTAFVKAGGSSGSDGKQDKVGGLGPPQDPAGKRTLSASAPRSAKRLRLDNGSPEPEPTPEGMGCSPWTDLPQAAAPSTEDNRHPLPASQSPSSPEETADSPDRAITEALRKIGEATFDLLPVIRSHVYVGNVSTKPVMRDQEKDVVYEFSTTKKHLAESLLHSILSELKSQKMSVEHNYIHALCRVYVGVCRQLGDLERARLFCYGLLKEDFPESEKLTLFIANMWHDVFISQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQPSVRFGEDLSDSTWEYVCAIDLLCCHQKWVWTHDNIISKELWPVMDKWIKYRKGHANVAYTPDIIVASVLRLIGRLGQLGLKEGFPSAVKNISTVIGMFIQHAQDEDIPWGVQLAAVYALCDLSPSNPAEISKILEAWRRETARSVPAAVLGALDEVGALCAEGRG", "length": 2178, "header": "tr|A0AAA9SPJ5-1|A0AAA9SPJ5_BOVIN Isoform 1 of Interactor of little elongation complex ELL subunit 1 OS=Bos taurus OX=9913 GN=ICE1 PE=4 SV=1 CANONICAL=A0AAA9SPJ5-1" }, "locus": { "chromosome": "20", "start_pos": 67715253, "end_pos": 67653373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109601.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109601.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085922.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085922.1" } ] } }, { "isoform_ac": "F1MS14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5/entry#F1MS14-1", "sequence": { "sequence": "MPAFGEEHRLLSWKNLNEYVDALITLKQKIINTDNLLTEYQKKFLQLQFARRENSTLHHQVEQMLQKISPLQKCQEELGFLKAELEEKKSSLKLYQDTHQEYARVKEECLKTDAQKKKLEAKVKKLEEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNERELRHIGTQISSDSYGSIDKRKVKLLLKELWLCINTTHRLPGEGGRYIPEKPAREYCRSIEFGEDGVPPAAGGSPIRTSAVQTCLAELSMEIEGDFSACEDVGGAAGRDNGLSQEDTSPKAVAWRSEAQGPGFDEDLQAAVDFFRLPPPLLSPVPSPPLASPPHLGVSPSLFAPEPFGEGANSSDYESAPCRNSEPVSKEDPPEAQDRCGLSGEKKGAGAWEEQPHTREAALALSAGTTLGFGTFAANLQEPAASFAFAREQLWTVSSELGSGREKGVVDKLGRHREVGQKDRLVPTVWTRPRAPGGKPAETLLGGLAREEGTAHGQSDPRPPPLGLQPLREPRAPDGKTLLSPWIESPKLELARWTLIDGTASESGRQSASGHFQGQPRALEKERGATQGCVSEGPPTPGTAGLSLGDAWSCSSASGASPCCGHPPSPSGLEDGGGPAIPPAVGPPRPCGSEQTTPAAGVTAVEVPPEPPGCSSGGARLESSFPTLCPMSGTSDPFGQRSGPLGCAAFVKDLSDACLLPQPPFPSRSSFPPRSAFPGAAGIGLAAGQALRVELAPARTGFRASPGPLSSLVRSGFGFGRSASWHHSDLLRRGSEARPRAVWSSEGGGSACVFTSEDRGPAAPRAPTSVLPNQVSVITRQARPGPAQPARPETPAPHGDARASWLACGAQHGGERRDTKSSARSPASGAPASWGRLDFDAPSGSFPVENSHHPTDCKSSFFSENIPVPNRDAVMGAAVQEEAQKQSPGLLATGVDTASLDVDKCPDTDLTLSGGFPAGDAVRCPGAALAVSQAPPALQRGLKERLLLESESPGCAPLEGLGAAETASPRPAPCCYSGIREAGGGDTEVEESEAPSSSEGEPEPDPALEPDLHSAPRARGWGAGPAEAGPSVEVGSLTSALQDFNISTLSEMDRLSTSEVVMFLESCQLRDYSSADSVSECSSKGTLNRGMKEELKPSGPSGEGYGSQLCEEEALETSEEWVESEEDDCTLRGQLPRCSLETLSEVLTRLGQELQASQEDSEAEEAEGLLLFRGPESATAEHLQQQLPPLDTAITASPTPRASAHTQGGSPTCAEPGRENTQSTPEGRVDAVRPAGNREEIQSEPEEPSVPNADPGAGPGEVRLQCQISTVTSEVINVLINKDQNLVIEKGDNWTIINGVTLMPELGQVILCDAPEAAPLSTHSEELAAGFLLVPPVERSPEAGRPGSPLQEPPCGRSAAGTQEDISSSGQSGNFDKSRLRNRPVKPSVRISSEIYDQNFESQAAPFDHTYCNSKLEPLGKNKNRSKVSNRDQSNKPVRTPASGRVETIEREVSPSFSGDRGHGRPQRSHTHTILATADTSTPADCCVDTLSKIRQEVGPPLPPLLAPLIATPPRTSRLASPLISSSSPSSPLSPLCPTSPSSEPPAPPVTSPLPEEPRPCSPLCASPSPSSAPAGNRVLSSPLQFCAATPKHALPVPGRLPPLAPAHPAVAAPPENSVKILDTMYPELSARARTLNILKGNIQLTRGPPANRKGLPGPVGALAGFQAIASSSTAFVKAGGSSGSDGKQDKVGGLGPPQDPAGKRTLSASAPRSAKRLRLDNGSPEPEPTPEGMGCSPWTDLPQAAAPSTEDNRHPLPASQSPSSPEETADSPDRAITEALRKIGEATFDLLPVIRSHVYVGNVSTKPVMRDQEKDVVYEFSTTKKHLAESLLHSILSELKSQKMSVEHNYIHALCRVYVGVCRQLGDLERARLFCYGLLKEDFPESEKLTLFIANMWHDVFISQSVINKAMQLVARQRAKGEVLNCLRAFLNWEKNAPVDVGFMVSKLLLTIQLCPKTEFQPSVRFGEDLSDSTWEYVCAIDLLCCHQKWVWTHDNIISKELWPVMDKWIKYRKGHANVAYTPDIIVASVLRLIGRLGQLGLKEGFPSAVKNISTVIGMFIQHAQDEDIPWGVQLAAVYALCDLSPSNPAEISKILEAWRRETARSVPAAVLGALDEVGALCAEGRG", "length": 2164, "header": "tr|F1MS14-1|A0AAA9SPJ5_BOVIN Computationally mapped isoform of Interactor of little elongation complex ELL subunit 1 OS=Bos taurus OX=9913 GN=ICE1 PE=4 SV=4 CANONICAL=A0AAA9SPJ5-1" }, "locus": { "chromosome": "20", "start_pos": 67716587, "end_pos": 67653373, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024626.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024626.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024626.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024626.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1780, "start_aa": "Thr", "end_pos": 1780, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1780", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 590, "start_aa": "Thr", "end_pos": 590, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr590", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "euchromatin", "id": "GO:0000791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000791", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "histone locus body", "id": "GO:0035363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035363", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of intracellular protein transport", "id": "GO:0090316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090316", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "positive regulation of protein-containing complex assembly", "id": "GO:0031334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase III", "id": "GO:0045945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045945", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "snRNA transcription by RNA polymerase II", "id": "GO:0042795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042795", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" }, { "name": "snRNA transcription by RNA polymerase III", "id": "GO:0042796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1095, "end_pos": 1097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1343, "end_pos": 1345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1474, "end_pos": 1476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1772, "end_pos": 1774, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1853, "end_pos": 1855, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2103, "end_pos": 2105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPJ5" }, { "id": "PF25817", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25817" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Little elongation complex subunit 1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 1977, "end_pos": 2169, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 590, 1780 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1095, "end_pos": 1097 }, { "start_pos": 1343, "end_pos": 1345 }, { "start_pos": 1474, "end_pos": 1476 }, { "start_pos": 1772, "end_pos": 1774 }, { "start_pos": 1853, "end_pos": 1855 }, { "start_pos": 2103, "end_pos": 2105 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ47-1", "uniprot_ac": "A0AAA9SQ47", "uniprot_id": "A0AAA9SQ47_BOVIN", "mass": { "chemical_mass": 43331.0, "monoisotopic_mass": 43331.0 }, "refseq": { "ac": "XP_005225573", "name": "sideroflexin-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225573" }, "gene_names": [ { "name": "SFXN2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ] }, { "name": "SFXN2", "type": "synonym", "evidence": [ { "id": "XP_005225573", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225573" } ] } ], "protein_names": [ { "name": "Sidoreflexin", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47/entry#names_and_taxonomy" } ] }, { "name": "sideroflexin-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225573", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225573" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SFXN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47", "locus": { "chromosome": "26", "start_pos": 23341592, "end_pos": 23323218, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004321", "url": "https://www.ensembl.org/id/ENSBTAG00000004321" } ] } } ], "crossref": [ { "id": "A0AAA9SQ47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513450", "url": "https://www.ncbi.nlm.nih.gov/gene/513450", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513450", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513450", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140T855", "url": "https://www.orthodb.org/?gene=A0A140T855", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11153:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11153:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225573", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225573", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A140T855", "url": "https://www.uniprot.org/uniprotkb/A0A140T855", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T855-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T855-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKTQQPVGLSIGGVDSLQLHERKPVITSVTKAGSEFDKKKDKISGTSLMPGEPKNKLECVPGRRMEADLSDFNIDAPRWDQCTFLGRVKHFFNITDPRTVLVPERELDWAKVMVEQSRMGTVPPGTQVEQLFYAKKLYDSAFHPDTGHKMNVIGRMSFQVPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMAVSYITATTTAVATAVGMNMLTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNHNEIGHSRRAAAIGITQVVISRITMAAPGMILLPVLMERLEKLRFVQRVRVLHAPLQVLLSGCFLIFMVPVACGLFPQQCELPVSYLEPELQDTIKAKYREPVPHVYFNKGL", "length": 387, "header": "tr|A0AAA9SQ47-1|A0AAA9SQ47_BOVIN Isoform 1 of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN2 PE=3 SV=1 CANONICAL=A0AAA9SQ47-1" }, "isoforms": [ { "isoform_ac": "A0A140T855-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47/entry#A0A140T855-1", "sequence": { "sequence": "MGRMEADLSDFNIDAPRWDQCTFLGRVKHFFNITDPRTVLVPERELDWAKVMVEQSRMGTVPPGTQVEQLFYAKKLYDSAFHPDTGHKMNVIGRMSFQVPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMAVSYITATTTAVATAVGMNMLTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNHNEIGHSRRAAAIGITQVVISRITMAAPGMILLPVLMERLEKLRFVQRVRVLHAPLQVLLSGCFLIFMVPVACGLFPQQCELPVSYLEPELQDTIKAKYREPVPHVYFNKGL", "length": 325, "header": "tr|A0A140T855-1|A0A140T855_BOVIN Computationally mapped isoform of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN2 PE=3 SV=3 CANONICAL=A0AAA9SQ47-1" }, "locus": { "chromosome": "26", "start_pos": 23340084, "end_pos": 23331464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005659.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005659.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005659.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005659.4" } ] } }, { "isoform_ac": "A0AAA9SPK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47/entry#A0AAA9SPK8-1", "sequence": { "sequence": "MQLPRISVASWMEADLSDFNIDAPRWDQCTFLGRVKHFFNITDPRTVLVPERELDWAKVMVEQSRMGTVPPGTQVEQLFYAKKLYDSAFHPDTGHKMNVIGRMSFQVPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMAVSYITATTTAVATAVGMNMLTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNHNEIGHSRRAAAIGITQVVISRITMAAPGMILLPVLMERLEKLRFVQRVRVLHAPLQVLLSGCFELPVSYLEPELQDTIKAKYREPVPHVYFNKGL", "length": 317, "header": "tr|A0AAA9SPK8-1|A0AAA9SQ47_BOVIN Computationally mapped isoform of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN2 PE=3 SV=2 CANONICAL=A0AAA9SQ47-1" }, "locus": { "chromosome": "26", "start_pos": 23340084, "end_pos": 23328560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115963.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115963.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088228.2" } ] } }, { "isoform_ac": "A0AAA9SQ47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47/entry#A0AAA9SQ47-1", "sequence": { "sequence": "MLKTQQPVGLSIGGVDSLQLHERKPVITSVTKAGSEFDKKKDKISGTSLMPGEPKNKLECVPGRRMEADLSDFNIDAPRWDQCTFLGRVKHFFNITDPRTVLVPERELDWAKVMVEQSRMGTVPPGTQVEQLFYAKKLYDSAFHPDTGHKMNVIGRMSFQVPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMAVSYITATTTAVATAVGMNMLTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNHNEIGHSRRAAAIGITQVVISRITMAAPGMILLPVLMERLEKLRFVQRVRVLHAPLQVLLSGCFLIFMVPVACGLFPQQCELPVSYLEPELQDTIKAKYREPVPHVYFNKGL", "length": 387, "header": "tr|A0AAA9SQ47-1|A0AAA9SQ47_BOVIN Isoform 1 of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN2 PE=3 SV=1 CANONICAL=A0AAA9SQ47-1" }, "locus": { "chromosome": "26", "start_pos": 23340084, "end_pos": 23325292, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090249.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090249.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088448.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088448.1" } ] } }, { "isoform_ac": "A0AAA9ST39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47/entry#A0AAA9ST39-1", "sequence": { "sequence": "MQLPRISVASWMEADLSDFNIDAPRWDQCTFLGRVKHFFNITDPRTVLVPERELDWAKVMVEQSRMGTVPPGTQVEQLFYAKKLYDSAFHPDTGHKMNVIGRMSFQVPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMAVSYITATTTAVATAVGMNMLTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNHNEIGHSRRAAAIGITQVVISRITMAAPGMILLPVLMERLEKLRFVQRVRVLHAPLQVLLSGCFNPAEYALLLSLRWLRGGLPQMAQLRSAQLGLEPSLIFMVPVACGLFPQQCELPVSYLEPELQDTIKAKYREPVPHVYFNKGL", "length": 367, "header": "tr|A0AAA9ST39-1|A0AAA9ST39_BOVIN Computationally mapped isoform of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN2 PE=3 SV=2 CANONICAL=A0AAA9SQ47-1" }, "locus": { "chromosome": "26", "start_pos": 23340084, "end_pos": 23328560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099508.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099508.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087154.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087154.2" } ] } }, { "isoform_ac": "A0AAA9TUT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47/entry#A0AAA9TUT4-1", "sequence": { "sequence": "MQLPRISVASWMEADLSDFNIDAPRWDQCTFLGRVKHFFNITDPRTVLVPERELDWAKVMVEQSRMGTVPPGTQVEQLFYAKKLYDSAFHPDTGHKMNVIGRMSFQVPGGMIITGFMLQFYRTMPAVIFWQWVNQSFNALVNYTNRNAASPTSVRQMAVSYITATTTAVATAVGMNMLTKRAPPLVGRWVPFAAVAAANCVNIPMMRQQELIQGICVKDRNHNEIGHSRRAAAIGITQVVISRITMAAPGMIPRGSLFCLVSAQRVRVLHAPLQVLLSGCFELPVSYLEPELQDTIKAKYREPVPHVYFNKGL", "length": 313, "header": "tr|A0AAA9TUT4-1|A0AAA9TUT4_BOVIN Computationally mapped isoform of Sidoreflexin OS=Bos taurus OX=9913 GN=SFXN2 PE=3 SV=2 CANONICAL=A0AAA9SQ47-1" }, "locus": { "chromosome": "26", "start_pos": 23340084, "end_pos": 23328560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124578.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124578.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101119.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101119.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513450", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513450", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" }, { "name": "mitochondrial transmembrane transport", "id": "GO:1990542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" }, { "name": "serine import into mitochondrion", "id": "GO:0140300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "monoatomic ion transmembrane transporter activity", "id": "GO:0015075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015075", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPL0-1", "uniprot_ac": "A0AAA9SPL0", "uniprot_id": "A0AAA9SPL0_BOVIN", "mass": { "chemical_mass": 53762.0, "monoisotopic_mass": 53762.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF713", "type": "recommended", "evidence": [ { "id": "A0AAA9SPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ] } ], "protein_names": [ { "name": "Zinc finger protein 713", "type": "synonym", "evidence": [ { "id": "A0AAA9SPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF713", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0", "locus": { "chromosome": "25", "start_pos": 27639697, "end_pos": 27622110, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008175", "url": "https://www.ensembl.org/id/ENSBTAG00000008175" } ] } } ], "crossref": [ { "id": "A0AAA9SPL0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPL0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100126443", "url": "https://www.ncbi.nlm.nih.gov/gene/100126443", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RN97", "url": "https://www.uniprot.org/uniprotkb/F6RN97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RN97-1", "url": "https://www.uniprot.org/uniprotkb/F6RN97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSQDAVLSQEGNTEKEMNVGSQTVMSQESLTFQDVAVDFTREEWDQLYPAQKNLYRDVMLENYRNLVALGHQLYKPEVITQLEQEEQWMMGRVSPPDTHPDGENRPEIKKSNHNMSDENQTHDMIMERLTGDSFWYSILGGLWEFDYQLEFNQENQQRYLGQVSFTHKKITQERGLECSRFGENYNLNSNLLMQQRIPSMKIPLNSDTQGNSIKRNSDLIYYQGNYVRENPYEYNECGKIFNQHLLLTSHIHTEGKHSECRKAFSQNSSLTQPQMVLTGEKPYKCDECGKRFSQRIHLIQHQRIHTGEKPFICNECGKAFRQHSSFTQHLRIHTGEKPYKCNQCGKAFSRITSLTEHHRLHTGEKPYECSFCGKAFSQRTHLNQHERTHTGEKPYKCNECEKAFSQSAHLNQHRKIHTREKLCSDREEVLFYTDRDFVRIPSPVCITVEVRSRGCTRG", "length": 459, "header": "tr|A0AAA9SPL0-1|A0AAA9SPL0_BOVIN Isoform 1 of Zinc finger protein 713 OS=Bos taurus OX=9913 GN=ZNF713 PE=3 SV=1 CANONICAL=A0AAA9SPL0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0/entry#A0AAA9SPL0-1", "sequence": { "sequence": "MPSQDAVLSQEGNTEKEMNVGSQTVMSQESLTFQDVAVDFTREEWDQLYPAQKNLYRDVMLENYRNLVALGHQLYKPEVITQLEQEEQWMMGRVSPPDTHPDGENRPEIKKSNHNMSDENQTHDMIMERLTGDSFWYSILGGLWEFDYQLEFNQENQQRYLGQVSFTHKKITQERGLECSRFGENYNLNSNLLMQQRIPSMKIPLNSDTQGNSIKRNSDLIYYQGNYVRENPYEYNECGKIFNQHLLLTSHIHTEGKHSECRKAFSQNSSLTQPQMVLTGEKPYKCDECGKRFSQRIHLIQHQRIHTGEKPFICNECGKAFRQHSSFTQHLRIHTGEKPYKCNQCGKAFSRITSLTEHHRLHTGEKPYECSFCGKAFSQRTHLNQHERTHTGEKPYKCNECEKAFSQSAHLNQHRKIHTREKLCSDREEVLFYTDRDFVRIPSPVCITVEVRSRGCTRG", "length": 459, "header": "tr|A0AAA9SPL0-1|A0AAA9SPL0_BOVIN Isoform 1 of Zinc finger protein 713 OS=Bos taurus OX=9913 GN=ZNF713 PE=3 SV=1 CANONICAL=A0AAA9SPL0-1" }, "locus": { "chromosome": "25", "start_pos": 27638076, "end_pos": 27623988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106926.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106926.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087293.1" } ] } }, { "isoform_ac": "A0AAA9TPC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0/entry#A0AAA9TPC8-1", "sequence": { "sequence": "MPSQDAVLSQEGNTEKEMNVGSQTVMSQESLTFQDVAVDFTREEWDQLYPAQKNLYRDVMLENYRNLVALGHQLYKPEVITQLEQEEQWMMGRVSPPDTHPDGENRPEIKKSNHNMSDENQTHDMIMERLTGDSFWYSILGGLWEFDYQLEFNQENQQRYLGQVSFTHKKITQERGLECSRFGENYNLNSNLLMQQRIPSMKIPLNSDTQGNSIKRNSDLIYYQGNYVRENPYEYNECGKIFNQHLLLTSHIHTEGKHSECRKAFSQNSSLTQPQMVLTGEKPYKCDECGKRFSQRIHLIQHQRIHTGEKPFICNECGKAFRQHSSFTQHLRIHTGEKPYKCNQCGKAFSRITSLTEHHRLHTGEKPYECSFCGKAFSQRTHLNQHERTHTGEKPYKCNECEKAFSQSAHLNQHRKIHTREKLCEYNKCEKTLSHSPSLTPQHITQNF", "length": 448, "header": "tr|A0AAA9TPC8-1|A0AAA9TPC8_BOVIN Computationally mapped isoform of Zinc finger protein 713 OS=Bos taurus OX=9913 GN=ZNF713 PE=3 SV=1 CANONICAL=A0AAA9SPL0-1" }, "locus": { "chromosome": "25", "start_pos": 27637073, "end_pos": 27623988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113404.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113404.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098873.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098873.1" } ] } }, { "isoform_ac": "F6RN97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0/entry#F6RN97-1", "sequence": { "sequence": "MPSQDAVLSQEGNTEKEMNVGSQTVMSQESLTFQDVAVDFTREEWDQLYPAQKNLYRDVMLENYRNLVALGHQLYKPEVITQLEQEEQWMMGRVSPPDTHPDGENRPEIKKSNHNMSDENQTHDMIMERLTGDSFWYSILGGLWEFDYQLEFNQENQQRYLGQVSFTHKKITQERGLECSRFGENYNLNSNLLMQQRIPSMKIPLNSDTQGNSIKRNSDLIYYQGNYVRENPYEYNECGKIFNQHLLLTSHIHTEGKHSECRKAFSQNSSLTQPQMVLTGEKPYKCDECGKRFSQRIHLIQHQRIHTGEKPFICNECGKAFRQHSSFTQHLRIHTGEKPYKCNQCGKAFSRITSLTEHHRLHTGEKPYECSFCGKAFSQRTHLNQHERTHTGEKPYKCNECEKAFSQSAHLNQHRKIHTREKL", "length": 423, "header": "tr|F6RN97-1|F6RN97_BOVIN Computationally mapped isoform of Zinc finger protein 713 OS=Bos taurus OX=9913 GN=ZNF713 PE=3 SV=1 CANONICAL=A0AAA9SPL0-1" }, "locus": { "chromosome": "25", "start_pos": 27636999, "end_pos": 27623988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010747.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010747.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010747.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010747.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 284, "end_pos": 311, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL0" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 101, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 120, "end_pos": 122 }, { "start_pos": 268, "end_pos": 270 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPL1-1", "uniprot_ac": "A0AAA9SPL1", "uniprot_id": "A0AAA9SPL1_BOVIN", "mass": { "chemical_mass": 52282.0, "monoisotopic_mass": 52282.0 }, "refseq": { "ac": "XP_015318749", "name": "ankyrin repeat domain-containing protein 34A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015318749" }, "gene_names": [ { "name": "ANKRD34A", "type": "recommended", "evidence": [ { "id": "A0AAA9SPL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1" } ] }, { "name": "ANKRD34A", "type": "synonym", "evidence": [ { "id": "XP_015318749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015318749" } ] } ], "protein_names": [ { "name": "Ankyrin repeat domain 34A", "type": "synonym", "evidence": [ { "id": "A0AAA9SPL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein 34A", "type": "synonym", "evidence": [ { "id": "XP_015318749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015318749" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKRD34A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1", "locus": { "chromosome": "3", "start_pos": 21417654, "end_pos": 21411408, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008365", "url": "https://www.ensembl.org/id/ENSBTAG00000008365" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008365", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008365", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538433", "url": "https://www.ncbi.nlm.nih.gov/gene/538433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538433", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MBJ0", "url": "https://www.orthodb.org/?gene=F1MBJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24156:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24156:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015318749", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015318749", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBJ0", "url": "https://www.uniprot.org/uniprotkb/F1MBJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBJ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MBJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPAPPSPGVCTSPSEIQLQTAGAGGRGLLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPAEGRPGFERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTGGGPLSRRNTAPEAQESGPSSGLRQKLSRMESVELDTPGNLCPDSPECSRPSLERRRYSASPLTLPLAGSVSSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHIAQTRPGFLPPLNVSPHPPIPDIRPGGRAPSLPAPPQAGAPGSPRTKRKLVRRHSMQTEQIRLLGGFQSLGGPGEPGR", "length": 494, "header": "tr|A0AAA9SPL1-1|A0AAA9SPL1_BOVIN Isoform 1 of Ankyrin repeat domain 34A OS=Bos taurus OX=9913 GN=ANKRD34A PE=3 SV=1 CANONICAL=A0AAA9SPL1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1/entry#A0AAA9SPL1-1", "sequence": { "sequence": "MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPAPPSPGVCTSPSEIQLQTAGAGGRGLLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPAEGRPGFERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTGGGPLSRRNTAPEAQESGPSSGLRQKLSRMESVELDTPGNLCPDSPECSRPSLERRRYSASPLTLPLAGSVSSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHIAQTRPGFLPPLNVSPHPPIPDIRPGGRAPSLPAPPQAGAPGSPRTKRKLVRRHSMQTEQIRLLGGFQSLGGPGEPGR", "length": 494, "header": "tr|A0AAA9SPL1-1|A0AAA9SPL1_BOVIN Isoform 1 of Ankyrin repeat domain 34A OS=Bos taurus OX=9913 GN=ANKRD34A PE=3 SV=1 CANONICAL=A0AAA9SPL1-1" }, "locus": { "chromosome": "3", "start_pos": 21415919, "end_pos": 21414438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113124.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113124.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103560.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103560.1" } ] } }, { "isoform_ac": "F1MBJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1/entry#F1MBJ0-1", "sequence": { "sequence": "MWAPRNPAPPPQLPRGPGLSPGPEEILRTYRSQTQAASLPPFSLWGCGNLKEGLASPLSPQASASHHPHPPRRPRQVPIPAPTVLSPQRQLCCTPRATLFFGPWVRNKARMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPAPPSPGVCTSPSEIQLQTAGAGGRGLLSPRAQEEEEKRDVFEFPLPKPPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPAEGRPGFERLTAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTGGGPLSRRNTAPEAQESGPSSGLRQKLSRMESVELDTPGNLCPDSPECSRPSLERRRYSASPLTLPLAGSVSSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHIAQTRPGFLPPLNVSPHPPIPDIRPGGRAPSLPAPPQAGAPGSPRTKRKLVRRHSMQTEQIRLLGGFQSLGGPGEPGR", "length": 546, "header": "tr|F1MBJ0-1|A0AAA9SPL1_BOVIN Computationally mapped isoform of Ankyrin repeat domain 34A OS=Bos taurus OX=9913 GN=ANKRD34A PE=3 SV=4 CANONICAL=A0AAA9SPL1-1" }, "locus": { "chromosome": "3", "start_pos": 21415919, "end_pos": 21413679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011013.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011013.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043164.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043164.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538433", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538433", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 429, "end_pos": 431 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPM6-1", "uniprot_ac": "A0AAA9SPM6", "uniprot_id": "A0AAA9SPM6_BOVIN", "mass": { "chemical_mass": 168796.0, "monoisotopic_mass": 168796.0 }, "refseq": {}, "gene_names": [ { "name": "MYOM2", "type": "recommended", "evidence": [ { "id": "A0AAA9SPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ] } ], "protein_names": [ { "name": "Myomesin 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYOM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6", "locus": { "chromosome": "27", "start_pos": 1516583, "end_pos": 1452630, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009387", "url": "https://www.ensembl.org/id/ENSBTAG00000009387" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009387", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009387", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05891", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05891", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20951", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20951", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524077", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524077", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ASFRFVI", "url": "https://omabrowser.org/oma/group/ASFRFVI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF23", "url": "https://www.orthodb.org/?gene=E1BF23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF23", "url": "https://www.uniprot.org/uniprotkb/E1BF23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF23-1", "url": "https://www.uniprot.org/uniprotkb/E1BF23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDGVAKMSLVAVPFYQKRHKHFDQSYRNIQTRYLLDEYSAKKKRASAQSSLQRSVTRKSSSQRESSRAALGESTLGETTLGETSLGDTTLGRTTCRLCAKRMSSALEEEAQERKRRYQSMVAAYGEAKRERYLSELAQLEEDVHVARTHARDQLDRLALQHAGRHGLHHAVDDRLAWERHSFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAGEPGKYRIDSKYGVHTLEINRADFDDTATYSAVATNVHGQVSTNAAVVVRRFRGDEEPFHSVGLPIGLPLSSVIPYTHFDVQFIEKFGVTFRREGETLTLKCTLLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLNKDDEGLYTLRIVSRGGITDHSAFLFVRDADPLVTGAPGAPMDVHCHDANRDYVIVTWKPPNATKESPVIGYFIDRCEVGTDNWIQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSEAVAALDPVDLRRLQAVHLEGEKDIVVYQEELEGEVQIPGPPTNVHASETSRTYVVLSWDPPEPRGKEPLMYFIEKSMVGSGSWQRVNAQTAVRSPRYAVFDLAEGKPYVFRVLSANKHGLSDPSEITAPIQAQDTIVVPSAPGRVLASRNTRTSVVVQWDRPKHEEDLLGYYVDCSVAGSNVWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMILGWKVPKFSGGSPILGYYVDKREAHHKNWHEVNSSPLKERILTVEGLTEGSLYEFKIAAANMAGIGQPSDPSELFKCEAWTMPEPGPAYDLTFCEVRDTSLVLLWKPPVYSGSSPVSGYFVDYKEEDSGEWLTVHETATPHRYLKVCDLHQGKTYVFRVRAVNASGVGRPSDTSEPVLVEARPGTKEVSAGVDEEGNVYLSFDCPEVTDASHFTWCKSYEDIADDDRFKVETAGDHSKLYFKNLDKEDLGTYSVSVSDTDGVSSSFVLDEEELERLKALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDSSYRFIINDREVADSETHRIKCDKSTGIIEMVMDRFTIDNEGTYTVQIQDGKAKSQSSLVLIGDAFKAVLKEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETEKMPDLEKGVCELLIPKLSKKDHGEYKATLKDDRGQDVSTLEIAGKVYEDMILAMSRVCGASASPLKILCTPEGIRLQCFMKYFTEEMKVNWYHKDAKITSSEHMRIGGNEQMAWLQICEPTEKDKGKYTFEILDGKKNHQRSLDLSGQAFDEAFAEFQQLKAAAFAEKNRGKVIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVVWFKNDKDIELSDHFSVKVEQGKYVSMTIKGVTSEDSGKYSIHVKNKYGGEKIDVTVSVYKHGEEIPDVVLPQQAKPKLLPAAAPSPAH", "length": 1502, "header": "tr|A0AAA9SPM6-1|A0AAA9SPM6_BOVIN Isoform 1 of Myomesin 2 OS=Bos taurus OX=9913 GN=MYOM2 PE=4 SV=1 CANONICAL=A0AAA9SPM6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6/entry#A0AAA9SPM6-1", "sequence": { "sequence": "MEDGVAKMSLVAVPFYQKRHKHFDQSYRNIQTRYLLDEYSAKKKRASAQSSLQRSVTRKSSSQRESSRAALGESTLGETTLGETSLGDTTLGRTTCRLCAKRMSSALEEEAQERKRRYQSMVAAYGEAKRERYLSELAQLEEDVHVARTHARDQLDRLALQHAGRHGLHHAVDDRLAWERHSFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAGEPGKYRIDSKYGVHTLEINRADFDDTATYSAVATNVHGQVSTNAAVVVRRFRGDEEPFHSVGLPIGLPLSSVIPYTHFDVQFIEKFGVTFRREGETLTLKCTLLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLNKDDEGLYTLRIVSRGGITDHSAFLFVRDADPLVTGAPGAPMDVHCHDANRDYVIVTWKPPNATKESPVIGYFIDRCEVGTDNWIQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSEAVAALDPVDLRRLQAVHLEGEKDIVVYQEELEGEVQIPGPPTNVHASETSRTYVVLSWDPPEPRGKEPLMYFIEKSMVGSGSWQRVNAQTAVRSPRYAVFDLAEGKPYVFRVLSANKHGLSDPSEITAPIQAQDTIVVPSAPGRVLASRNTRTSVVVQWDRPKHEEDLLGYYVDCSVAGSNVWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMILGWKVPKFSGGSPILGYYVDKREAHHKNWHEVNSSPLKERILTVEGLTEGSLYEFKIAAANMAGIGQPSDPSELFKCEAWTMPEPGPAYDLTFCEVRDTSLVLLWKPPVYSGSSPVSGYFVDYKEEDSGEWLTVHETATPHRYLKVCDLHQGKTYVFRVRAVNASGVGRPSDTSEPVLVEARPGTKEVSAGVDEEGNVYLSFDCPEVTDASHFTWCKSYEDIADDDRFKVETAGDHSKLYFKNLDKEDLGTYSVSVSDTDGVSSSFVLDEEELERLKALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDSSYRFIINDREVADSETHRIKCDKSTGIIEMVMDRFTIDNEGTYTVQIQDGKAKSQSSLVLIGDAFKAVLKEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETEKMPDLEKGVCELLIPKLSKKDHGEYKATLKDDRGQDVSTLEIAGKVYEDMILAMSRVCGASASPLKILCTPEGIRLQCFMKYFTEEMKVNWYHKDAKITSSEHMRIGGNEQMAWLQICEPTEKDKGKYTFEILDGKKNHQRSLDLSGQAFDEAFAEFQQLKAAAFAEKNRGKVIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVVWFKNDKDIELSDHFSVKVEQGKYVSMTIKGVTSEDSGKYSIHVKNKYGGEKIDVTVSVYKHGEEIPDVVLPQQAKPKLLPAAAPSPAH", "length": 1502, "header": "tr|A0AAA9SPM6-1|A0AAA9SPM6_BOVIN Isoform 1 of Myomesin 2 OS=Bos taurus OX=9913 GN=MYOM2 PE=4 SV=1 CANONICAL=A0AAA9SPM6-1" }, "locus": { "chromosome": "27", "start_pos": 1516267, "end_pos": 1454902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104774.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104774.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085887.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085887.1" } ] } }, { "isoform_ac": "E1BF23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6/entry#E1BF23-1", "sequence": { "sequence": "MSLVAVPFYQKRHKHFDQSYRNIQTRYLLDEYSAKKKRASAQSSLQRSVTRKSSSQRESSRAALGESTLGETTLGETSLGDTTLGRTTCRLCAKRMSSALEEEAQERKRRYQSMVAAYGEAKRERYLSELALQHAGRHGLHHAVDDRLAWERHSFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAGEPGKYRIDSKYGVHTLEINRADFDDTATYSAVATNVHGQVSTNAAVVVRRFRGDEEPFHSVGLPIGLPLSSVIPYTHFDVQFIEKFGVTFRREGETLTLKCTLLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLNKDDEGLYTLRIVSRGGITDHSAFLFVRDADPLVTGAPGAPMDVHCHDANRDYVIVTWKPPNATKESPVIGYFIDRCEVGTDNWIQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSEAVAALDPVDLRRLQAVHLEGEKDIVVYQEELEGEVQIPGPPTNVHASETSRTYVVLSWDPPEPRGKEPLMYFIEKSMVGSGSWQRVNAQTAVRSPRYAVFDLAEGKPYVFRVLSANKHGLSDPSEITAPIQAQDTIVVPSAPGRVLASRNTRTSVVVQWDRPKHEEDLLGYYVDCSVAGSNVWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMILGWKVPKFSGGSPILGYYVDKREAHHKNWHEVNSSPLKERILTVEGLTEGSLYEFKIAAANMAGIGQPSDPSELFKCEAWTMPEPGPAYDLTFCEVRDTSLVLLWKPPVYSGSSPVSGYFVDYKEEDSGEWLTVHETATPHRYLKVCDLHQGKTYVFRVRAVNASGVGRPSDTSEPVLVEARPGTKEVSAGVDEEGNVYLSFDCPEVTDASHFTWCKSYEDIADDDRFKVETAGDHSKLYFKNLDKEDLGTYSVSVSDTDGVSSSFVLDEEELERLKALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDSSYRFIINDREVADSETHRIKCDKSTGIIEMVMDRFTIDNEGTYTVQIQDGKAKSQSSLVLIGDAFKAVLKEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETEKMPDLEKGVCELLIPKLSKKDHGEYKATLKDDRGQDVSTLEIAGKVYEDMILAMSRVCGASASPLKILCTPEGIRLQCFMKYFTEEMKVNWYHKDAKITSSEHMRIGGNEQMAWLQICEPTEKDKGKYTFEILDGKKNHQRSLDLSGQAFDEAFAEFQQLKAAAFAEKNRGKVIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVVWFKNDKDIELSDHFSVKVEQGKYVSMTIKGVTSEDSGKYSIHVKNKYGGEKIDVTVSVYKHGEEIPDVVLPQQAKPKLLPAAAPSPAH", "length": 1474, "header": "tr|E1BF23-1|A0AAA9SPM6_BOVIN Computationally mapped isoform of Myomesin 2 OS=Bos taurus OX=9913 GN=MYOM2 PE=4 SV=4 CANONICAL=A0AAA9SPM6-1" }, "locus": { "chromosome": "27", "start_pos": 1516267, "end_pos": 1458412, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012351.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012351.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012351.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012351.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524077", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524077", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AC90-1", "protein_name": "Myomesin 2", "gene_name": "Myom2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLGEAALCLNIAPPLAINGGKHGALQGEISSAVLGQCLGNSSTALFVSAGFFPLGISKMSLVVVPFYQKRHKHFDQSYRNIQTRYLLDRYASKKQASSQSSSQRSLTERSSSKRASSQSSAEGMTCRLCAKRMSASEEEEVENENRYRSLAASYGEAKRQRFLSELAQLEENVQLARTQARNKLDKYFLEQTVADNLALERSSFEDRLSRAPEILVRLRSHTIWERMSVRLCFTVQGFPTPVVQWYKDGSLICQAGEPGKYRIESRYGVHTLEINRADFEDTATYSAVATNPHGQVSTNAAVVVRRYRGDEEPYHSVGLPIGLPLSSVIPYTHFDVQFLEKFGVTFRREGETVTLKCTLLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLNKDDEGLYTLRIVSRGGVSDHSAFMFVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVIGYFIDKCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYVFRVRAVNNAGISRPSRISDAVAALDPVDLRRLQAIHLEGEKEIVIYQDDLEGDVQIPGPPTNVQASEVSRNYVVLSWDPPSPRGKEPLMYFIEKSAVGSGSWQRVNAQTAVRSPRYAVFDLAEGKSYVFRVLSANKHGLSDPSEITPPIQAQDMIVVPSAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNMWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQESEVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSAIIGYYLDKREVHHKNWHEINSSPVKERILTVEGLTEGSLYEFKIAATNLAGIGQPSDPSEHFKCEAWTAPEPGPAYDLTFCEVRDTSLVILWKAPVYSGSSPVSGYFVDFKEEDSGEWKTTSEAATPNRYLKVCDLHQGKTYVFRVRAVNASGPGKPSDTSEPVLVEARPGTKEISAGVDEEGNIYLGFDCQEMTDASQFTWCKAYEEIADEERFEVHTEGDHSKLYFKNPDKIDIGTYSVSVSDTDGVSSSFVLDEEELERLMALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDANFRFIINDREVSDSETHRIKCDRSTGMIEMVMDRFTIENEGTYTVQIQDGKAKNQSSLVLIGDAFRAVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLICKVANTKRETVFKWLKDDVLYETETPPPDLEKGICELLIPKLSKKDHGEYKATLKDDRGQDVSVLEVAGKVYEDMILAMSRVCGASASPLKVLCTPEGIRLQCFMKYFTEEMKVSWYHKEAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAYAEFQQLKAAAFAEKNRGKVIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVVWFKNDKDIELSEHFSVKVEQSKYVSLTIKGVTAEDSGKYSINVKNKYGGEKIDVTVSVYKHGEKIPDISAPQQAKPKLIPASTSAD", "length": 1523 }, "evidence": [ { "id": "A0AAA9SPM6", "url": "https://omabrowser.org/oma/group/A0AAA9SPM6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XD40-1", "protein_name": "Myomesin 2", "gene_name": "MYOM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSVAVPFYQRRHKHFDQSYRNIQTRYVLEEYAARKAASRQAAHYESTGLGKTTCRLCARRARSLAHEAMQESRKRTHEQKSHASDEKRIKFASELSSLEREIHMARHHAREQLDRLAIQRMVEENMALERHVVEEKISRAPEILVRLRSHTVWEKMSVRLCFTVQGFPSPVVQWYKNEELITPASDPAKYSVENKYGVHVLHINRADFDDSATYSAVATNIHGQASTNCAVVVRRFRESEEPHPAGIMPFHLPLSYDVCFTHFDVQFLEKFGVTFATEGETLTLKCSVLVTPELKRLRPRAEWYRDDVLIKDSKWTKLYFGEGQAALSFTHLNKDDEGLYTLRMVTKGGVNECSAFLFVRDADALIAGAPGAPMDVKCHDANRDYVIVTWKPPNTTSQNPVIGYFVDKCEVGLENWVQCNDAPVKICKYPVTGLYEGRSYIFRVRAVNSAGISRPSRVSEPVAALDPVDLERTQTVHVDEGRKIVISKDDLEVAVLITLPGDIQIPGPPTNVHASEISKTYVVLSWDPPVPRGREPLTYFIEKSMVGSGSWQRVNAQVAVKSPRYAVFDLAEGKPYVFRVLSANKHGISDPSEITEPIQPQDIVVVPSAPGRVVATRNTKTSVVVQWDKPKHEENLYGYYIDYSVVGSNQWEPANHKPINYNRFVVHGLETGEQYIFRVKAVNAVGFSENSQESEAIKVQAALTCPSYPHGITLLNCDGHSMTLGWKAPKYSGGSPILGYYIDKREANHKNWHEVNSSVISRTIYTVEDLTEDAFYEFKIAAANVVGIGHPSDPSEHFKCKAWTMPEPGPAYDLTVCEVRNTSLVLLWKAPVYEGKSPITGYLVDYKEVDTEDWITANEKPTSHRYFKVTDLHQGHTYVFKVRAVNDAGVGKSSEISEPVFVEASPGTKEIFSGVDEEGNIYLGFECKEATDASHFLWGKSYEEIEDSDKFKIETKGDHSKLYFKHPDKSDLGTYCISVSDTDGVSSSFVLDEEELERLMTLSNEIKNPTIPLKSELAYEVLDKGEVRFWIQAESLSPNSTYRFVINDKEVENGDRHKISCDHSNGIIEMVMDKFTIDNEGTYTVQIQDGKAKNQSSLVLIGDAFKAILAESELQRKEFLRKQGPHFSEFLYWEVTEECEVLLACKIANTKKETVFKWYRNGSGIDVDEAPDLQKGECHLTIPKLSRKDEGVYKATLSDDRGHDVSTLELSGKVYNDIILALSRVSGKTASPLKILCTEEGIRLQCFLKYYNEEMKVTWSHRESKISSGEKMKIGGGEDVAWLQITEPTEKDKGNYTFEIFSDKESFKRTLDLSGQAFDDALTEFQRLKAAAFAEKNRGKVIGGLPDVVTIMDGKTLNLTCTVFGNPDPEVVWFKNDKALELNEHYLVSLEQGKYASLTIKGVTSEDSGKYSIYVKNKYGGETVDVTVSVYRHGEKIPEVNQGQLAKPRLIPPSSST", "length": 1458 }, "evidence": [ { "id": "A0AAA9SPM6", "url": "https://omabrowser.org/oma/group/A0AAA9SPM6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7EYE1-1", "protein_name": "Uncharacterized protein LOC334269", "gene_name": "myom2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPAKGVTLYRQEQTHQQSSKHVVHQSRKSSSQVVKKEQVQATEVMVEPAYTVPNFRERAPEGMQEYQRMAAHFGRDLVQIQQELHRMKVATKEQVQNIEITREVKGMMPLRKEFPTEVPKAPDFLVSLRSHTVWEKTPVKLFCTVSGQPTPIVKWYRNNVAIEPLSAPGKYKIENKYGVHSLIISRCAVSDSGVYSAVATNPQGKATSKATVCVRRPAGGGELSHLPGLVPLGGIHPSKLEVTLLESFGVTFGKEGESVSLVSNMVVVPDLPNLPPEAVWYRDDALLMPSRWAEMSVGGGVAKLTLPYLNKDDEGLYTLRIWTKDGTVEHSAYLFVKDAAPTVSGAPGAPMDVTATDVNADYVLISWKPPNTTHEAPITGYFVDKRKSGTKDWVQCNDSPVKVCKLPVHGLTDGASYHFRVRAVNKSGISLPSRMSSGVTTGEVESDVEVIKIEGKYDIAIRQEELQGVYVTIPGPPTNVHATEINKTYIVLSWTPPSPRGRAPVWYLIEKCVGDSDIWQRVNTAVQLRSPRYPVYDMEDKKAYRFRVITVNKYGSSEPSEPTAPIQKVDLYGIVPNIGVPSAPGQVIASRNTKTSAFVQWDAPKHATNLLGYYVDASVVGSKDWFPCNHRPYKHTRFVVHGLTPGDTYVFRVQAVNAYGLSEESQESAPLFIDAALKGAVEYATPSAPYGISLLNCNGSSMTLAWKRPKHTGGSKISSYYLDKREAGSVDWKEVSPSPAVHRIFTVENLTGGVFYEFKIQAANLAGVGLPSEPSKPFACEAWTMAEPGPAYDISFWEVRDTSILVQWKPPVYTGQSPVTGYFVDMAKKGSSDFATVNAEKVEHCFLKVTGLESGASYVFRVRAVNDKGVGKASDLSDPICAKALPGTKEIVCGVDEETGDIFLKFEACEVSETSKFIWSKSYKEVTESSRASITSSGRHSKLTFVNPEKEDLGIYSVAVTDTDGVSSSYSVNEEELKKMLDLSYNIRHPIVPLKTELNYEILEKGHVRFWVQALKLSSSVNYRFIVNDKAISSTEGYKISHDVSTGIIQMTIEHFTKANEGTYTIQIHDGKAKSQSSLVLVGDAFKVALKEADFQRKEHIRKQGPHFSEYLSFYVTDDCTVMLVCKLANVKKETKFTWFKEEEEITVDVQPNPMSGSCSLPIPMFSRKDQGIYKAVLSDDRGKDTSVYDISGKVFEDIINAIASIAGSSASDLVLQCTPEGIRLQCYMKYYTEEMKASWFHRESKISSSEKMRIGGTSEMAWMQICEPTDKEKGSYAIEIHDGKKAHTRNFDLSGQAYTDAYAEFQRLKAAAFAEKNRGRVMGGLPDVVTIMEKKSLSLTCTVWGDPSPEVTWFKNEQEVVSDDRYKITFESGKFASLTIKSVYVEDSGKYSINVRNKYGGEFVEITVSVYKQGEDIPEPKLGQMSRPAATPKPATPVPQSVKTPSPATPTPSIKSPTPTPPSSVKSPTPTPASKSPTPPRSMRSPTPPRSMRSPTPTKK", "length": 1501 }, "evidence": [ { "id": "A0AAA9SPM6", "url": "https://omabrowser.org/oma/group/A0AAA9SPM6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P54296-1", "protein_name": "Myomesin-2", "gene_name": "MYOM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLVTVPFYQKRHRHFDQSYRNIQTRYLLDEYASKKRASTQASSQKSLSQRSSSQRASSQTSLGGTICRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQRFLSELAHLEEDVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFLFVRDADPLVTGAPGAPMDLQCHDANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIAIYQDDLEGDAQVPGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYFIEKSVVGSGSWQRVNAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQTTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTKEISAGVDEQGNIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKEDLGTYSVSVSDTDGVSSSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKGRVRFWLQAEHLSPDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFSIENEGTYTVQIHDGKAKSQSSLVLIGDAFKTVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKKETVFKWLKDDVLYETETLPNLERGICELLIPKLSKKDHGEYKATLKDDRGQDVSILEIAGKVYDDMILAMSRVCGKSASPLKVLCTPEGIRLQCFMKYFTDEMKVNWCHKDAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQRSLDLSGQAFDEAFAEFQQFKAAAFAEKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVIWFKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKNKYGGEKIDVTVSVYKHGEKIPDMAPPQQAKPKLIPASASAAGQ", "length": 1465 }, "evidence": [ { "id": "A0AAA9SPM6", "url": "https://omabrowser.org/oma/group/A0AAA9SPM6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "pmid": "" }, { "name": "structural constituent of muscle", "id": "GO:0008307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "myosin filament", "id": "GO:0032982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "pmid": "" }, { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 798, "end_pos": 800, "annotation": "n_glycosylation_sequon" }, { "start_pos": 928, "end_pos": 930, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 422, "end_pos": 516, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 191, "end_pos": 282, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1400, "end_pos": 1402 }, { "start_pos": 444, "end_pos": 446 }, { "start_pos": 798, "end_pos": 800 }, { "start_pos": 928, "end_pos": 930 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPQ8-1", "uniprot_ac": "A0AAA9SPQ8", "uniprot_id": "A0AAA9SPQ8_BOVIN", "mass": { "chemical_mass": 45490.0, "monoisotopic_mass": 45490.0 }, "refseq": {}, "gene_names": [ { "name": "TM2D3", "type": "recommended", "evidence": [ { "id": "A0AAA9SPQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8" } ] } ], "protein_names": [ { "name": "TM2 domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SPQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM2D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8", "locus": { "chromosome": "21", "start_pos": 28844007, "end_pos": 28805445, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007649", "url": "https://www.ensembl.org/id/ENSBTAG00000007649" } ] } } ], "crossref": [ { "id": "A0AAA9SPQ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPQ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007649", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007649", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512588", "url": "https://www.ncbi.nlm.nih.gov/gene/512588", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJX5", "url": "https://www.orthodb.org/?gene=A0A3Q1LJX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21016:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21016:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LJX5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJX5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FLFVTKRTDPVTGKQWPTSQTCQPLPSILQEGESEVKVAQSCPTLCDPTDNTWNSPGYNTGVGSLSLLQGIFLTQGSNPGLLHCGQILYQLRHKGERAAAPAPALWPRPDPPPRRARAPRPSRVPARPEESAPARWRLRWSCCGLFADCVVWCCSSHSSTSCRAAFVGDQASRFAQAAEAWSAAAPPEVSVSPVAGSFSEEPSQPLPQAIKDPGPTRTFTAVPRAAESTDIPPYVMKCPSNGLCSRLPADCIDCKTNFSCVYGKPVTFDCTVKPSVTCVDPDFKSQKSFVLNMTCRFCWQLPEADYECFSSSDCRAVSCPRQRYPTNCTVRDHVHCLGNRTFPKMLYCNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI", "length": 417, "header": "tr|A0AAA9SPQ8-1|A0AAA9SPQ8_BOVIN Isoform 1 of TM2 domain-containing protein 3 OS=Bos taurus OX=9913 GN=TM2D3 PE=3 SV=1 CANONICAL=A0AAA9SPQ8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8/entry#A0A3Q1LJX5-1", "sequence": { "sequence": "MAAAVVLLRPLCRLCRVVLFLSQFYILSGGESTDIPPYVMKCPSNGLCSRLPADCIDCKTNFSCVYGKPVTFDCTVKPSVTCVDPDFKSQKSFVLNMTCRFCWQLPEADYECFSSSDCRAVSCPRQRYPTNCTVRDHVHCLGNRTFPKMLYCNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI", "length": 221, "header": "tr|A0A3Q1LJX5-1|A0A3Q1LJX5_BOVIN Computationally mapped isoform of TM2 domain-containing protein 3 OS=Bos taurus OX=9913 GN=TM2D3 PE=3 SV=2 CANONICAL=A0AAA9SPQ8-1" }, "locus": { "chromosome": "21", "start_pos": 28828213, "end_pos": 28805988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076057.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076057.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056783.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056783.2" } ] } }, { "isoform_ac": "A0AAA9SPQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8/entry#A0AAA9SPQ8-1", "sequence": { "sequence": "FLFVTKRTDPVTGKQWPTSQTCQPLPSILQEGESEVKVAQSCPTLCDPTDNTWNSPGYNTGVGSLSLLQGIFLTQGSNPGLLHCGQILYQLRHKGERAAAPAPALWPRPDPPPRRARAPRPSRVPARPEESAPARWRLRWSCCGLFADCVVWCCSSHSSTSCRAAFVGDQASRFAQAAEAWSAAAPPEVSVSPVAGSFSEEPSQPLPQAIKDPGPTRTFTAVPRAAESTDIPPYVMKCPSNGLCSRLPADCIDCKTNFSCVYGKPVTFDCTVKPSVTCVDPDFKSQKSFVLNMTCRFCWQLPEADYECFSSSDCRAVSCPRQRYPTNCTVRDHVHCLGNRTFPKMLYCNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI", "length": 417, "header": "tr|A0AAA9SPQ8-1|A0AAA9SPQ8_BOVIN Isoform 1 of TM2 domain-containing protein 3 OS=Bos taurus OX=9913 GN=TM2D3 PE=3 SV=1 CANONICAL=A0AAA9SPQ8-1" }, "locus": { "chromosome": "21", "start_pos": 28828213, "end_pos": 28805446, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099217.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099217.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084904.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 216, "start_aa": "Thr", "end_pos": 216, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr216", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ8" }, { "id": "PF05154", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05154" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TM2", "eco_id": "ECO_0000259", "start_pos": 353, "end_pos": 400, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 216 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 349, "end_pos": 351 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPS6-1", "uniprot_ac": "A0AAA9SPS6", "uniprot_id": "A0AAA9SPS6_BOVIN", "mass": { "chemical_mass": 65310.0, "monoisotopic_mass": 65310.0 }, "refseq": {}, "gene_names": [ { "name": "CSTF2T", "type": "recommended", "evidence": [ { "id": "A0AAA9SPS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6" } ] } ], "protein_names": [ { "name": "Cleavage stimulation factor subunit 2 tau variant", "type": "synonym", "evidence": [ { "id": "A0AAA9SPS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSTF2T", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6", "locus": { "chromosome": "26", "start_pos": 7517151, "end_pos": 7514053, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018406", "url": "https://www.ensembl.org/id/ENSBTAG00000018406" } ] } } ], "crossref": [ { "id": "A0AAA9SPS6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPS6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12671", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12671", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45735", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45735", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45735:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45735:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14304", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14304", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLR1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQGGIPPQGPMPAAVPGPGPLTPGGTMQPQVGMPGVGPVPLERGQVQISDPRAPMPRGPMTAGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHAAGHDSRGPSSHEMRGGPLADPRMLMSEPRGPMIDQRGLPMDGRGSRDSRGMETRAMETEVLETRVMERRGMETCAMETRAMEARGMDARGMEMRGPGPSSRGPMTGGIQGPGPINMGAGGPQGPRQVPSISGVGNPGPGIQGAGMQGAGMQGAGMQGGGMQGPGMQGAGMQGAGMQGAGMQGAGMQGAGMQGPGMQGAGKQGGGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGTS", "length": 622, "header": "tr|A0AAA9SPS6-1|A0AAA9SPS6_BOVIN Isoform 1 of Cleavage stimulation factor subunit 2 tau variant OS=Bos taurus OX=9913 GN=CSTF2T PE=4 SV=1 CANONICAL=A0AAA9SPS6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6/entry#A0AAA9SPS6-1", "sequence": { "sequence": "MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQGGIPPQGPMPAAVPGPGPLTPGGTMQPQVGMPGVGPVPLERGQVQISDPRAPMPRGPMTAGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHAAGHDSRGPSSHEMRGGPLADPRMLMSEPRGPMIDQRGLPMDGRGSRDSRGMETRAMETEVLETRVMERRGMETCAMETRAMEARGMDARGMEMRGPGPSSRGPMTGGIQGPGPINMGAGGPQGPRQVPSISGVGNPGPGIQGAGMQGAGMQGAGMQGGGMQGPGMQGAGMQGAGMQGAGMQGAGMQGAGMQGPGMQGAGKQGGGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGTS", "length": 622, "header": "tr|A0AAA9SPS6-1|A0AAA9SPS6_BOVIN Isoform 1 of Cleavage stimulation factor subunit 2 tau variant OS=Bos taurus OX=9913 GN=CSTF2T PE=4 SV=1 CANONICAL=A0AAA9SPS6-1" }, "locus": { "chromosome": "26", "start_pos": 7516147, "end_pos": 7514252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129805.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129805.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084927.1" } ] } }, { "isoform_ac": "A0AAF6DLR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6/entry#A0AAF6DLR1-1", "sequence": { "sequence": "MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSGPGPGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQGGIPPQGPMPAAVPGPGPLTPGGTMQPQVGMPGVGPVPLERGQVQISDPRAPMPRGPMTAGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHAAGHDSRGPSSHEMRGGPLADPRMLMSEPRGPMIDQRGLPMDGRGSRDSRGMETRAMETEVLETRVMERRGMETCAMETRAMEARGMDARGMEMRGPGPSSRGPMTGGIQGPGPINMGAGGPQGPRQVPSISGVGNPGPGIQGAGMQGAGMQGAGMQGAGMQGPGMQGAGKQGGGQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGTS", "length": 592, "header": "tr|A0AAF6DLR1-1|A0AAF6DLR1_BOVIN Computationally mapped isoform of Cleavage stimulation factor subunit 2 tau variant OS=Bos taurus OX=9913 GN=CSTF2T PE=4 SV=1 CANONICAL=A0AAA9SPS6-1" }, "locus": { "chromosome": "26", "start_pos": 7516147, "end_pos": 7514252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024491.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024491.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054873.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054873.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA 3'-end processing", "id": "GO:0031124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS6" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 94, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPV7-1", "uniprot_ac": "A0AAA9SPV7", "uniprot_id": "A0AAA9SPV7_BOVIN", "mass": { "chemical_mass": 52429.0, "monoisotopic_mass": 52429.0 }, "refseq": { "ac": "XP_024851101", "name": "repulsive guidance molecule B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851101" }, "gene_names": [ { "name": "RGMB", "type": "recommended", "evidence": [ { "id": "A0AAA9SPV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ] }, { "name": "RGMB", "type": "synonym", "evidence": [ { "id": "XP_024851101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851101" } ] } ], "protein_names": [ { "name": "Repulsive guidance molecule BMP co-receptor b", "type": "synonym", "evidence": [ { "id": "A0AAA9SPV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7/entry#names_and_taxonomy" } ] }, { "name": "repulsive guidance molecule B", "type": "synonym", "evidence": [ { "id": "XP_024851101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851101" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGMB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7", "locus": { "chromosome": "7", "start_pos": 98032173, "end_pos": 98035209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011864", "url": "https://www.ensembl.org/id/ENSBTAG00000011864" } ] } } ], "crossref": [ { "id": "A0AAA9SPV7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "540954", "url": "https://www.ncbi.nlm.nih.gov/gene/540954", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540954", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540954", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31428:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31428:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851101", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851101", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMKKKRKRGAPSGPCRRPGPGPATAPAPPPSPEPTRAAWTGMGLRAASPSCAAAAPASAAAAAGAEPRRRPRRRPGLGPPPLALLLLLLLSLGLLHAGDCQQPAQCRIQKCTTDFVSLTSHLNSAVDGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYHSHAGAREHRGGDQNPPNYLFCGLFGDPHLRTFKDHFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKITIIFKAHRECTDQKVYQAVTDDLPAAFVDGSTSGGDGDPKSLRIVERESGRSVEMHARYMGTTVFVRQLGRYLTLAIRMPEALAMAYEESQDLQLCVTGCPLGERIDDGQGQVSAILGPGLPRSPAAPAWPGYTLETASARCHEQMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWHIFPSSARGAPRGRPLSSVSLGLTCLILVVFL", "length": 489, "header": "tr|A0AAA9SPV7-1|A0AAA9SPV7_BOVIN Isoform 1 of Repulsive guidance molecule BMP co-receptor b OS=Bos taurus OX=9913 GN=RGMB PE=3 SV=1 CANONICAL=A0AAA9SPV7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7/entry#A0AAA9SPV7-1", "sequence": { "sequence": "MMKKKRKRGAPSGPCRRPGPGPATAPAPPPSPEPTRAAWTGMGLRAASPSCAAAAPASAAAAAGAEPRRRPRRRPGLGPPPLALLLLLLLSLGLLHAGDCQQPAQCRIQKCTTDFVSLTSHLNSAVDGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYHSHAGAREHRGGDQNPPNYLFCGLFGDPHLRTFKDHFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKITIIFKAHRECTDQKVYQAVTDDLPAAFVDGSTSGGDGDPKSLRIVERESGRSVEMHARYMGTTVFVRQLGRYLTLAIRMPEALAMAYEESQDLQLCVTGCPLGERIDDGQGQVSAILGPGLPRSPAAPAWPGYTLETASARCHEQMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWHIFPSSARGAPRGRPLSSVSLGLTCLILVVFL", "length": 489, "header": "tr|A0AAA9SPV7-1|A0AAA9SPV7_BOVIN Isoform 1 of Repulsive guidance molecule BMP co-receptor b OS=Bos taurus OX=9913 GN=RGMB PE=3 SV=1 CANONICAL=A0AAA9SPV7-1" }, "locus": { "chromosome": "7", "start_pos": 98032841, "end_pos": 98008457, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132639.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132639.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085973.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 179, "start_aa": "Thr", "end_pos": 179, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr179", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540954", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540954", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" }, { "id": "PF06534", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06534" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Repulsive guidance molecule C-terminal", "eco_id": "ECO_0000259", "start_pos": 211, "end_pos": 452, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SPV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPV7" }, { "id": "PF06535", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06535" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Repulsive guidance molecule N-terminal", "eco_id": "ECO_0000259", "start_pos": 106, "end_pos": 175, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 179 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 435, "end_pos": 437 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPX3-1", "uniprot_ac": "A0AAA9SPX3", "uniprot_id": "A0AAA9SPX3_BOVIN", "mass": { "chemical_mass": 10374.0, "monoisotopic_mass": 10374.0 }, "refseq": {}, "gene_names": [ { "name": "FAM240A", "type": "recommended", "evidence": [ { "id": "A0AAA9SPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 240 member A", "type": "synonym", "evidence": [ { "id": "A0AAA9SPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM240A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3", "locus": { "chromosome": "22", "start_pos": 52836432, "end_pos": 52841404, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062614", "url": "https://www.ensembl.org/id/ENSBTAG00000062614" } ] } } ], "crossref": [ { "id": "A0AAA9SPX3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR40387", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40387", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR40387:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40387:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27680", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27680", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLFSGMNNQYVRREVFCRNTCHELKRFWEREIGKQTYYRESEEHRLGRSALRKLREEWKQKVETKLRLRNNPDETEKQANVGQ", "length": 84, "header": "tr|A0AAA9SPX3-1|A0AAA9SPX3_BOVIN Isoform 1 of Family with sequence similarity 240 member A OS=Bos taurus OX=9913 GN=FAM240A PE=4 SV=1 CANONICAL=A0AAA9SPX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX3/entry#A0AAA9SPX3-1", "sequence": { "sequence": "MLLFSGMNNQYVRREVFCRNTCHELKRFWEREIGKQTYYRESEEHRLGRSALRKLREEWKQKVETKLRLRNNPDETEKQANVGQ", "length": 84, "header": "tr|A0AAA9SPX3-1|A0AAA9SPX3_BOVIN Isoform 1 of Family with sequence similarity 240 member A OS=Bos taurus OX=9913 GN=FAM240A PE=4 SV=1 CANONICAL=A0AAA9SPX3-1" }, "locus": { "chromosome": "22", "start_pos": 52841404, "end_pos": 52836432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088349.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088349.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPY5-1", "uniprot_ac": "A0AAA9SPY5", "uniprot_id": "A0AAA9SPY5_BOVIN", "mass": { "chemical_mass": 17971.0, "monoisotopic_mass": 17971.0 }, "refseq": { "ac": "XP_002691396", "name": "interleukin-36 beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691396" }, "gene_names": [ { "name": "IL36B", "type": "recommended", "evidence": [ { "id": "A0AAA9SPY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ] }, { "name": "IL36B", "type": "synonym", "evidence": [ { "id": "XP_002691396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691396" } ] } ], "protein_names": [ { "name": "Interleukin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9SPY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5/entry#names_and_taxonomy" } ] }, { "name": "interleukin-36 beta", "type": "synonym", "evidence": [ { "id": "XP_002691396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691396" } ] } ], "function": [ { "annotation": "Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5#function" }, { "database": "UniProtKB", "id": "ARBA00034096", "url": "https://www.uniprot.org/uniprotkb/ARBA00034096#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL36B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5", "locus": { "chromosome": "11", "start_pos": 46717319, "end_pos": 46708894, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059479", "url": "https://www.ensembl.org/id/ENSBTAG00000059479" } ] } } ], "crossref": [ { "id": "A0AAA9SPY5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23300", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23300", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100297786", "url": "https://www.ncbi.nlm.nih.gov/gene/100297786", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000975", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000975", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100297786", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297786", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10078", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10078", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10078:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10078:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00340", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00340", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691396", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691396", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MECPMLREYPSYLHIRDSRQMVWVVKGNSLIAVPSSNNIKPVILSLIACRDMEFNKEGNGTPHYLGIKDKNLCLYCTEIQGYPTLQLKEENIMNLYNKPKGEKCFLFYRNDEGSTVVFQSVSYPGWFIATSSEAGHPVTLTKERGTVQSTNYYLEGGL", "length": 158, "header": "tr|A0AAA9SPY5-1|A0AAA9SPY5_BOVIN Isoform 1 of Interleukin-1 OS=Bos taurus OX=9913 GN=IL36B PE=3 SV=1 CANONICAL=A0AAA9SPY5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5/entry#A0AAA9SPY5-1", "sequence": { "sequence": "MECPMLREYPSYLHIRDSRQMVWVVKGNSLIAVPSSNNIKPVILSLIACRDMEFNKEGNGTPHYLGIKDKNLCLYCTEIQGYPTLQLKEENIMNLYNKPKGEKCFLFYRNDEGSTVVFQSVSYPGWFIATSSEAGHPVTLTKERGTVQSTNYYLEGGL", "length": 158, "header": "tr|A0AAA9SPY5-1|A0AAA9SPY5_BOVIN Isoform 1 of Interleukin-1 OS=Bos taurus OX=9913 GN=IL36B PE=3 SV=1 CANONICAL=A0AAA9SPY5-1" }, "locus": { "chromosome": "11", "start_pos": 46716315, "end_pos": 46709956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111138.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111138.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086003.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086003.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297786", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297786", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ], "pmid": "" }, { "name": "interleukin-1 receptor binding", "id": "GO:0005149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ27-1", "uniprot_ac": "A0AAA9SQ27", "uniprot_id": "A0AAA9SQ27_BOVIN", "mass": { "chemical_mass": 76007.0, "monoisotopic_mass": 76007.0 }, "refseq": { "ac": "XP_003587192", "name": "tectonic-2 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587192" }, "gene_names": [ { "name": "TCTN2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ] }, { "name": "TCTN2", "type": "synonym", "evidence": [ { "id": "XP_003587192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587192" } ] } ], "protein_names": [ { "name": "Tectonic family member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27/entry#names_and_taxonomy" } ] }, { "name": "tectonic-2 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_003587192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587192" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCTN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27", "locus": { "chromosome": "17", "start_pos": 51998301, "end_pos": 52027617, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007271", "url": "https://www.ensembl.org/id/ENSBTAG00000007271" } ] } } ], "crossref": [ { "id": "A0AAA9SQ27", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ27", "database": "AlphaFoldDB", "categories": [] }, { "id": "100847961", "url": "https://www.ncbi.nlm.nih.gov/gene/100847961", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040354", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040354", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847961", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847961", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GWFPFLC", "url": "https://omabrowser.org/oma/group/GWFPFLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14611", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14611", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14611:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14611:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587192", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587192", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8K5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLSPPVPLLLGLLLLQGVLRPLRGDLVFIPSVIRMSGSVVSASLVGGTEDVTVSLTQLRDEMGLLPVPTCGELNNETGDWSLTVTPTVNSLEVTVRLKRDMQSCSSNGTDPFLEAPCIVQALLVSAFHNTSCLAHLLIHVEIYANSSLGQNASENVTVVPNQVYQPLGPCPCNLTAGACDIRCCCDQECSSDLTALFRESCFPGVFGGDVNPPFDQLCSIQMSHGVPDWFPFLCVQLANSPFLGYFYHGSISSGHQVSFGIYLHTDLKDFSDFGYKQGDPVMTVDKAYFTIPQVSLAGQCLYNAPVAFLQNFDVQCVTSLEEYLERDGITSAKIKNGAMGGIVTPKVIYEEATDLDRFITNTETLLSTGPAPRNVNVEEHYIFRWNNNTISEINVRIIRAEINAQQKGIMTQRFTVKFLSYNSGNKQEWSGNPGYQLGKPVRALSTNGTNNVTTLHLWYPAGGSLCSTATRKPILFGENVLSGCLLEVGINENCTKLRENAVELLDSLVQVTHVAMRGNSDYNDLSDGWLEIIRVDALGAGADPPDSNVSGICLDVPAQLNIRILFSDAGAVEGMTQQEILGVETRFSSVTWQFQCGLTCEDKADLFPIGASVQFIKIPAQLPHPLTRFQINFTEYDCNRNEVCWPQLLYPLTQYYRGEPYSQCVAKSLLLVSFIILAVFLSNPWIRIHKA", "length": 692, "header": "tr|A0AAA9SQ27-1|A0AAA9SQ27_BOVIN Isoform 1 of Tectonic family member 2 OS=Bos taurus OX=9913 GN=TCTN2 PE=3 SV=1 CANONICAL=A0AAA9SQ27-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27/entry#A0AAA9SQ27-1", "sequence": { "sequence": "MRLSPPVPLLLGLLLLQGVLRPLRGDLVFIPSVIRMSGSVVSASLVGGTEDVTVSLTQLRDEMGLLPVPTCGELNNETGDWSLTVTPTVNSLEVTVRLKRDMQSCSSNGTDPFLEAPCIVQALLVSAFHNTSCLAHLLIHVEIYANSSLGQNASENVTVVPNQVYQPLGPCPCNLTAGACDIRCCCDQECSSDLTALFRESCFPGVFGGDVNPPFDQLCSIQMSHGVPDWFPFLCVQLANSPFLGYFYHGSISSGHQVSFGIYLHTDLKDFSDFGYKQGDPVMTVDKAYFTIPQVSLAGQCLYNAPVAFLQNFDVQCVTSLEEYLERDGITSAKIKNGAMGGIVTPKVIYEEATDLDRFITNTETLLSTGPAPRNVNVEEHYIFRWNNNTISEINVRIIRAEINAQQKGIMTQRFTVKFLSYNSGNKQEWSGNPGYQLGKPVRALSTNGTNNVTTLHLWYPAGGSLCSTATRKPILFGENVLSGCLLEVGINENCTKLRENAVELLDSLVQVTHVAMRGNSDYNDLSDGWLEIIRVDALGAGADPPDSNVSGICLDVPAQLNIRILFSDAGAVEGMTQQEILGVETRFSSVTWQFQCGLTCEDKADLFPIGASVQFIKIPAQLPHPLTRFQINFTEYDCNRNEVCWPQLLYPLTQYYRGEPYSQCVAKSLLLVSFIILAVFLSNPWIRIHKA", "length": 692, "header": "tr|A0AAA9SQ27-1|A0AAA9SQ27_BOVIN Isoform 1 of Tectonic family member 2 OS=Bos taurus OX=9913 GN=TCTN2 PE=3 SV=1 CANONICAL=A0AAA9SQ27-1" }, "locus": { "chromosome": "17", "start_pos": 52027321, "end_pos": 51998798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125113.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125113.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085030.1" } ] } }, { "isoform_ac": "A0AAA9T8K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27/entry#A0AAA9T8K5-1", "sequence": { "sequence": "MRLSPPVPLLLGLLLLQGVLRPLRGDLVFIPSVIRMSGSVVSASLVGGTEDVTVSLTQLRDEMGLLPVPTCGELNNETGDWSLTVTPTVNSLEVTVRLKRDMQSCSSNGTDPFLEAPCIVQALLVSAFHNTSCLAHLLIHVEIYANSSLGQNASGMKNFAPSQTEIRTRKRMEGQPGENVTVVPNQVYQPLGPCPCNLTAGACDIRCCCDQECSSDLTALFRESCFPGVFGGDVNPPFDQLCSIQMSHGVPDWFPFLCVQLANSPFLGYFYHGSISSGHQVSFGIYLHTDLKDFSDFGYKQGDPVMTVDKAYFTIPQVSLAGQCLYNAPVAFLQNFDVQCVTSLEEYLERDGITSAKIKNGAMGGIVTPKVIYEEATDLDRFITNTETLLSTGPAPRNVNVEEHYIFRWNNNTISEINVRIIRAEINAQQKGIMTQRFTVKFLSYNSGNKQEWSGNPGYQLGKPVRALSTNGTNNVTTLHLWYPAGGSLCSTATRKPILFGENVLSGCLLEVGINENCTKLRENAVELLDSLVQVTHVAMRGNSDYNDLSDGWLEIIRVDALGAGADPPDSNVSGICLDVPAQLNIRILFSDAGAVEGMTQQEILGVETRFSSVTWQFQCGLTCEDKADLFPIGASVQFIKIPAQLPHPLTRFQINFTEYDCNRNEVCWPQLLYPLTQYYRGEPYSQCVAKSLLLVSFIILAVFLSNPWIRIHKA", "length": 715, "header": "tr|A0AAA9T8K5-1|A0AAA9T8K5_BOVIN Computationally mapped isoform of Tectonic family member 2 OS=Bos taurus OX=9913 GN=TCTN2 PE=3 SV=1 CANONICAL=A0AAA9SQ27-1" }, "locus": { "chromosome": "17", "start_pos": 52027321, "end_pos": 51998798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106800.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106800.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092953.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092953.1" } ] } }, { "isoform_ac": "A0AAA9TGC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27/entry#A0AAA9TGC7-1", "sequence": { "sequence": "MRLSPPVPLLLGLLLLQGVLRPLRGDLVFIPSVIRMSGSVVSASLVGGTEDVTVSLTQLRDEMGLLPVPTCGELNNETGDWSLTVTPTVNSLEVTVRLKRDMQSCSSNGTDPFLEAPCIVQALLVSAFHNTSCLAHLLIHVEIYANSSLGQNASENVTVVPNQVYQPLGPCPCNLTAGACDIRCCCDQECSSDLTALFRESCFPGVFGGDVNPPFDQLCSIQMSHGVPDWFPFLCVQLANSPFLGYFYHGSISSGHQVSFGIYLHTDLKDFSDFGYKQGDPVMTVDKAYFTIPQVSLAGQCLYNAPVAFLQNFDVQCVTSLEEYLERDGITSAKIKNGAMGGIVTPKVIYEEATDLDRFITNTETLLSTGPAPRNVNVEEHYIFRWNNNTISEINVRIIRAEINAQQKGIMTQRFTVKFLSYNSGNKQEWSGNPAGGSLCSTATRKPILFGENVLSGCLLEVGINENCTKLRENAVELLDSLVQVTHVAMRGNSDYNDLSDGWLEIIRVDALGAGADPPDSNVSGICLDVPAQLNIRILFSDAGAVEGMTQQEILGVETRFSSVTWQFQCGLTCEDKADLFPIGASVQFIKIPAQLPHPLTRFQINFTEYDCNRNEVCWPQLLYPLTQYYRGEPYSQCVAKSLLLVSFIILAVFLSNPWIRIHKA", "length": 665, "header": "tr|A0AAA9TGC7-1|A0AAA9TGC7_BOVIN Computationally mapped isoform of Tectonic family member 2 OS=Bos taurus OX=9913 GN=TCTN2 PE=3 SV=1 CANONICAL=A0AAA9SQ27-1" }, "locus": { "chromosome": "17", "start_pos": 52027321, "end_pos": 51998798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117270.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117270.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095926.1" } ] } }, { "isoform_ac": "A0AAA9TMC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27/entry#A0AAA9TMC0-1", "sequence": { "sequence": "MRLSPPVPLLLGLLLLQGVLRPLRGDLVFIPSVIRMSGSVVSASLVGGTEDVTVSLTQLRDEMGLLPVPTCGELNNETGDWSLTVTPTVVRPENSLEVTVRLKRDMQSCSSNGTDPFLEAPCIVQALLVSAFHNTSCLAHLLIHVEIYANSSLGQNASENVTVVPNQVYQPLGPCPCNLTAGACDIRCCCDQECSSDLTALFRESCFPGVFGGDVNPPFDQLCSIQMSHGVPDWFPFLCVQLANSPFLGYFYHGSISSGHQVSFGIYLHTDLKDFSDFGYKQGDPVMTVDKAYFTIPQVSLAGQCLYNAPVAFLQNFDVQCVTSLEEYLERDGITSAKIKNGAMGGIVTPKVIYEEATDLDRFITNTETLLSTGPAPRNVNVEEHYIFRWNNNTISEINVRIIRAEINAQQKGIMTQRFTVKFLSYNSGNKQEWSGNPGYQLGKPVRALSTNGTNNVTTLHLWYPAGGSLCSTATRKPILFGENVLSGCLLEVGINENCTKLRENAVELLDSLVQVTHVAMRGNSDYNDLSDGWLEIIRVDALGAGADPPDSNVSGICLDVPAQLNIRILFSDAGAVEGMTQQEILGVETRFSSVTWQFQCGLTCEDKADLFPIGASVQFIKIPAQLPHPLTRRALLSVCCQELTTGILHHFSCIPQ", "length": 657, "header": "tr|A0AAA9TMC0-1|A0AAA9TMC0_BOVIN Computationally mapped isoform of Tectonic family member 2 OS=Bos taurus OX=9913 GN=TCTN2 PE=3 SV=1 CANONICAL=A0AAA9SQ27-1" }, "locus": { "chromosome": "17", "start_pos": 52027321, "end_pos": 51998826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099624.1" } ] } }, { "isoform_ac": "A0AAA9TS77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27/entry#A0AAA9TS77-1", "sequence": { "sequence": "MRLSPPVPLLLGLLLLQGVLRPLRGDLVFIPSVIRMSGSVVSASLVGGTEDVTVSLTQLRDEMGLLPVPTCGELNNETGDWSLTVTPTVNSLEVTVRLKRDMQSCSSNGTDPFLEAPCIVQALLVSAFHNTSCLAHLLIHVEIYANSSLGQNASENVTVVPNQVYQPLGPCPCNLTAGACDIRCCCDQECSSDLTALFRESCFPGVFGGDVNPPFDQLCSIQMSHGVPDWFPFLCVQLANSPFLGYFYHGSISSGHQVSFGIYLHTDLKDFSDFGYKQGDPVMTVDKAYFTIPQVSLAGQCLYNAPVAFLQNFDVQCVTSLEEYLERDGITSAKIKNGAMGGIVTPKVIYEEATDLDRFITNTETLLSTGPAPRNVNVEEHYIFRWNNNTISEINVRIIRAEINAQQKGIMTQRFTVKFLSYNSGNKQEWSGNPGYQLGKPVRALSTNGTNNVTTLHLWYPAGGSLCSTATRKPILFGENVLSGCLLEVGINENCTKLRENAVELLDSLVQVTHVAMRGNSDYNDLSDGWLEIIRVDALGAGADPPDSNVSGICLDVPAQLNIRILFSDAGAVEGMTQQEILGVETRFQINFTEYDCNRNEVCWPQLLYPLTQYYRGEPYSQCVAKSLLLVSFIILAVFLSNPWIRIHKA", "length": 650, "header": "tr|A0AAA9TS77-1|A0AAA9TS77_BOVIN Computationally mapped isoform of Tectonic family member 2 OS=Bos taurus OX=9913 GN=TCTN2 PE=3 SV=1 CANONICAL=A0AAA9SQ27-1" }, "locus": { "chromosome": "17", "start_pos": 52027321, "end_pos": 51998798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099984.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099984.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101452.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100847961", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847961", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNM1-1", "protein_name": "Tectonic family member 2", "gene_name": "TCTN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFQSFQASKAGAVLCCRPREIPGMRLPPPVSLLLGFLLLQGVFSPLWGDLVFIPPVIRMSGPAVSASLVGGTEDVTVSLTLLQDEMGLFPVPDCRMLSNETGNWSLTVTPSMNSLEVTVRLKRDLQSCSSNETASFSESPCIVQTLLVSASRNSSCLAHLLIQAEIYANSSLAHNASENVTVIPNQVYQPLGPCPCNLTAGACDVRCCCDQECSSDLTALFRESCFPGIFGGDVNPPFDQLCSVQKVHGGPDWFPFLCVQLANSPFLGYFYHGSVSPGQHASFEVYLHTDLKDFSDFGYKQGDPVMTVDEAYFTVPQVSLAGQCMQNAPVAFLQNFDVQCVTNLEIFPEQDRIINVKIKNGAMGGIVTPKVIYEDATDLDRVITNTETLLSSGPAARNVNVEEHYIFRWNNNTISEIDVKIIRAEINVHQKGIMTQRFSVKFLSSNSGTEMESSGNPVSLRSPCDKQIMLITPQAFRNRPAQLLVVLQGYQLGKPIRALNTNRKNNVTTLYLWQSAGRGLCTSATLKPILFGENALSGCLLQVGMNENCTQLRENAVELLDSLIQATHVAMRGNSHYNNLNNDWLEIIRTDAPDTGADPTVSSSNGVCPDVPAQLSIRILFSDAGAVEGITQQEILGVETRFSSVTWQYQCGLTCEDEADLFPISASVQFIKIPAQLPRPLTRDHCSCCAQDRKRQEQPAGLQCRASDSAFRSSQRPGTQREARKAGTSRKHHLKL", "length": 737 }, "evidence": [ { "id": "A0AAA9SQ27", "url": "https://omabrowser.org/oma/group/A0AAA9SQ27/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2MV57-1", "protein_name": "Tectonic-2", "gene_name": "Tctn2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSLSPLSLLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRATLVGGSEDVAVSLSLLQVEEGVLPVPTCGGRRNETVDWNVTVSPRESTLEVTIRWKRGLDWCSADETASFSEPPCVLQMLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVIPNQVYQPLGPCPCDLTAKACDIQCCCDQDCQPEVRELFAQSCFSGVFGGHVSPPSHHHCAVSTTHQTPDWFPLLCVQSPPSTSPFLGHFYHGATSPRHSPGFEAHLHFDLRDFADASYKQGDPIMTTEGYFTIPQVSLAGQCLQDAPVAFLRNFDSVCTMDLEVHQGRDEIVLENMKIRTTGGPVTPTVTYEEAIDLDKFITSPDTVLSVGSAPRNVNVEEHYVFRWQNNSISGLDITVIRAEISAQQRGMMTQRFTVKFLSHHSGGEKEFSGNPGYQLGKPVRALHTAGMNVSTLHLWQPAGRGLCTAAALRPILFGENAFSGCLLEVGIKENCTQLRENVLQRLDLLTQATHVARRGNSDYSDLSDGWLEIIRAEAPDTGADLPLSSVNGVCPEVPARLSIRILTAEAGSVEGVAQREILAVETRFSTVTWQYQCGLTCEDKADLLPLSASVEFINVPAQMPHPPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPQSQCVAKGLMLLSLLMLAILLRHPWVRMCKARDSAAIYH", "length": 700 }, "evidence": [ { "id": "A0AAA9SQ27", "url": "https://omabrowser.org/oma/group/A0AAA9SQ27/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96GX1-1", "protein_name": "Tectonic-2", "gene_name": "TCTN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFQPPAALLLRLFLLQGILRLLWGDLAFIPPFIRMSGPAVSASLVGDTEGVTVSLAVLQDEAGILPIPTCGVLNNETEDWSVTVIPGAKVLEVTVRWKRGLDWCSSNETDSFSESPCILQTLLVSASHNSSCSAHLLIQVEIYANSSLTHNASENVTVIPNQVYQPLGPCPCNLTAGACDVRCCCDQECSSNLTTLFRRSCFTGVFGGDVNPPFDQLCSAGTTTRGVPDWFPFLCVQSPLANTPFLGYFYHGAVSPKQDSSFEVYVDTDAKDFADFGYKQGDPIMTVKKAYFTIPQVSLAGQCMQNAPVAFLHNFDVKCVTNLELYQERDGIINAKIKNVALGGIVTPKVIYEEATDLDKFITNTETPLNNGSTPRIVNVEEHYIFKWNNNTISEINVKIFRAEINAHQKGIMTQRFVVKFLSYNSGNEEELSGNPGYQLGKPVRALNINRMNNVTTLHLWQSAGRGLCTSATFKPILFGENVLSGCLLEVGINENCTQLRENAVERLDSLIQATHVAMRGNSDYADLSDGWLEIIRVDAPDPGADPLASSVNGMCLDIPAHLSIRILISDAGAVEGITQQEILGVETRFSSVNWQYQCGLTCEHKADLLPISASVQFIKIPAQLPHPLTRFQINYTEYDCNRNEVCWPQLLYPWTQYYQGELHSQCVAKGLLLLLFLTLALFLSNPWTRICKAYS", "length": 697 }, "evidence": [ { "id": "A0AAA9SQ27", "url": "https://omabrowser.org/oma/group/A0AAA9SQ27/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ], "pmid": "" }, { "name": "protein localization to ciliary transition zone", "id": "GO:1904491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 452, "end_pos": 454, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 549, "end_pos": 551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" }, { "id": "PF07773", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07773" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tectonic-1-3", "eco_id": "ECO_0000259", "start_pos": 273, "end_pos": 421, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ27" }, { "id": "PF25752", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25752" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tectonic-1-3 N-terminal", "eco_id": "ECO_0000259", "start_pos": 146, "end_pos": 255, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 152, "end_pos": 154 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 448, "end_pos": 450 }, { "start_pos": 452, "end_pos": 454 }, { "start_pos": 494, "end_pos": 496 }, { "start_pos": 549, "end_pos": 551 }, { "start_pos": 633, "end_pos": 635 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ44-1", "uniprot_ac": "A0AAA9SQ44", "uniprot_id": "A0AAA9SQ44_BOVIN", "mass": { "chemical_mass": 17485.0, "monoisotopic_mass": 17485.0 }, "refseq": {}, "gene_names": [ { "name": "KRTAP5-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44" } ] } ], "protein_names": [ { "name": "Keratin associated protein 5-2", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTAP5-2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44", "locus": {} } ], "crossref": [ { "id": "A0AAA9SQ44", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ44", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SQ44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCCGCSGGCGSSCGGCASSCGGCGSSCGGCGSSCGGCGSCGGCGSSCCVPVCCCKPVCCCVPACSCSSCGKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCSQSSCCKPCCSQSSCCKPCCSQSSCCIPVCCSQSSCCKPCCSQSSCCIPVCCSQSSCCKPCCSQSSCCVPECCQRKI", "length": 187, "header": "tr|A0AAA9SQ44-1|A0AAA9SQ44_BOVIN Isoform 1 of Keratin associated protein 5-2 OS=Bos taurus OX=9913 GN=KRTAP5-2 PE=4 SV=1 CANONICAL=A0AAA9SQ44-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ44/entry#A0AAA9SQ44-1", "sequence": { "sequence": "MGCCGCSGGCGSSCGGCASSCGGCGSSCGGCGSSCGGCGSCGGCGSSCCVPVCCCKPVCCCVPACSCSSCGKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCSQSSCCKPCCSQSSCCKPCCSQSSCCIPVCCSQSSCCKPCCSQSSCCIPVCCSQSSCCKPCCSQSSCCVPECCQRKI", "length": 187, "header": "tr|A0AAA9SQ44-1|A0AAA9SQ44_BOVIN Isoform 1 of Keratin associated protein 5-2 OS=Bos taurus OX=9913 GN=KRTAP5-2 PE=4 SV=1 CANONICAL=A0AAA9SQ44-1" }, "locus": { "chromosome": "29", "start_pos": 49862568, "end_pos": 49862008, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097449.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097449.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086060.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086060.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ46-1", "uniprot_ac": "A0AAA9SQ46", "uniprot_id": "A0AAA9SQ46_BOVIN", "mass": { "chemical_mass": 52797.0, "monoisotopic_mass": 52797.0 }, "refseq": {}, "gene_names": [ { "name": "DIPK2B", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46" } ] } ], "protein_names": [ { "name": "Divergent protein kinase domain 2B", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIPK2B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46", "locus": { "chromosome": "X", "start_pos": 98605072, "end_pos": 98556863, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020717", "url": "https://www.ensembl.org/id/ENSBTAG00000020717" } ] } } ], "crossref": [ { "id": "A0AAA9SQ46", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020717", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR020519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR32073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32073:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32073:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12260", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12260", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBN4", "url": "https://www.uniprot.org/uniprotkb/F1MBN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MBN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRLGPKAAALHLGWPFLLLWVSGLSYSVSSPASPSPSPVSRVRTSYNLGKTFLGLDKCNACIGTSICKKFFKEEIRFDNGLALHLGPPPDDLPSYSANYSDDFKTWRPVEISRLVSKQQNKISDGRICASAAAPKTCSIERVLRKTGRFQKWLQAKRLTPDLVRGLSSPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNTHPVLLQIFPGAEGWPLPKYLGSCGRFLVSTSTSPLQEFYGAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHVDADMFGIFNNGHLFIRDASALGVIDRQEGSQAASGAGDNKDIFSCLVSGCQTKLPSCDTIPEKQNLVLVCSQVLPLLLQAKFPSPVQEEIDAELTRCADGTRPDPEVLGAASRLKDILRPLRTCDPRFAYRYPDCKLWVDLERQLGSQYARIPRLALHQAQEGILLKQVIWGALGSPSMLRKF", "length": 475, "header": "tr|A0AAA9SQ46-1|A0AAA9SQ46_BOVIN Isoform 1 of Divergent protein kinase domain 2B OS=Bos taurus OX=9913 GN=DIPK2B PE=3 SV=1 CANONICAL=A0AAA9SQ46-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46/entry#A0AAA9SQ46-1", "sequence": { "sequence": "MEPRLGPKAAALHLGWPFLLLWVSGLSYSVSSPASPSPSPVSRVRTSYNLGKTFLGLDKCNACIGTSICKKFFKEEIRFDNGLALHLGPPPDDLPSYSANYSDDFKTWRPVEISRLVSKQQNKISDGRICASAAAPKTCSIERVLRKTGRFQKWLQAKRLTPDLVRGLSSPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNTHPVLLQIFPGAEGWPLPKYLGSCGRFLVSTSTSPLQEFYGAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHVDADMFGIFNNGHLFIRDASALGVIDRQEGSQAASGAGDNKDIFSCLVSGCQTKLPSCDTIPEKQNLVLVCSQVLPLLLQAKFPSPVQEEIDAELTRCADGTRPDPEVLGAASRLKDILRPLRTCDPRFAYRYPDCKLWVDLERQLGSQYARIPRLALHQAQEGILLKQVIWGALGSPSMLRKF", "length": 475, "header": "tr|A0AAA9SQ46-1|A0AAA9SQ46_BOVIN Isoform 1 of Divergent protein kinase domain 2B OS=Bos taurus OX=9913 GN=DIPK2B PE=3 SV=1 CANONICAL=A0AAA9SQ46-1" }, "locus": { "chromosome": "X", "start_pos": 98604068, "end_pos": 98556961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110267.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110267.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085053.1" } ] } }, { "isoform_ac": "F1MBN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46/entry#F1MBN4-1", "sequence": { "sequence": "MEPRLGPKAAALHLGWPFLLLWVSGLSYSVSSPASPSPSPVSRVRTSYNLGKTFLGLDKCNACIGTSICKKFFKEEIRFDNGLALHLGPPPDDLPSYSANYSDDFKTWRPVEISRLVSKQQNKISDGRICASAAAPKTCSIERVLRKTGRFQKWLQAKRLTPDLVRGLSSPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNTHPVLLQVCSDPALESLSGRGFTSGSEGIFPGAEGWPLPKYLGSCGRFLVSTSTSPLQEFYGAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHVDADMFGIFNNGHLFIRDASALGVIDRQEGSQAASGAGDNKDIFSCLVSGCQTKLPSCDTIPEKQNLVLVCSQVLPLLLQAKFPSPVQEEIDAELTRCADGTRPDPEVLGAASRLKDILRPLRTCDPRFAYRYPDCKYDDKF", "length": 454, "header": "tr|F1MBN4-1|A0AAA9SQ46_BOVIN Computationally mapped isoform of Divergent protein kinase domain 2B OS=Bos taurus OX=9913 GN=DIPK2B PE=3 SV=2 CANONICAL=A0AAA9SQ46-1" }, "locus": { "chromosome": "X", "start_pos": 98599377, "end_pos": 98556961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027608.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027608.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027608.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027608.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ46" }, { "id": "PF12260", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12260" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM69 protein-kinase", "eco_id": "ECO_0000259", "start_pos": 211, "end_pos": 391, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ51-1", "uniprot_ac": "A0AAA9SQ51", "uniprot_id": "A0AAA9SQ51_BOVIN", "mass": { "chemical_mass": 34790.0, "monoisotopic_mass": 34790.0 }, "refseq": { "ac": "NP_001377722", "name": "olfactory receptor family 9 subfamily S member 36", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377722" }, "gene_names": [ { "name": "OR9S36", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51" } ] }, { "name": "OR9S36", "type": "synonym", "evidence": [ { "id": "NP_001377722", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377722" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 9 subfamily S member 36", "type": "synonym", "evidence": [ { "id": "NP_001377722", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377722" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377722" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9S36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51", "locus": { "chromosome": "3", "start_pos": 119621371, "end_pos": 119620421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065755", "url": "https://www.ensembl.org/id/ENSBTAG00000065755" } ] } } ], "crossref": [ { "id": "A0AAA9SQ51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ51", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15419", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15419", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112446047", "url": "https://www.ncbi.nlm.nih.gov/gene/112446047", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112446047", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112446047", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377722", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPPKNGNLSETPLLEFVLEGFEGGPQTQALLFALFLALYVVAVLGNLTMIVVITLDAHLHSPMYFFLKNLSFLDLCYSSIIAPKALANFLSSSKVITFKGCATQFFFFSMMGTTEAFLLAVMAYDRFMAICSPLLYPITMYPSVCACLVLGSYCGGCFNSILQTSFTFSLPFCSSNHINHFFCDVVPLLQLTCANTAINKLVMFGLCGLIIVGTTLMVLVSYGYITLTILRMHSGGGRHKLFSTCGSHMTAVSLFYGTVFVMYAQPGAVQSMEQGKVVSVFYTLVIPMLNPLIYSLRNKDVKDALRRLIQKHIAT", "length": 316, "header": "tr|A0AAA9SQ51-1|A0AAA9SQ51_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9S36 PE=3 SV=1 CANONICAL=A0AAA9SQ51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51/entry#A0AAA9SQ51-1", "sequence": { "sequence": "MQPPKNGNLSETPLLEFVLEGFEGGPQTQALLFALFLALYVVAVLGNLTMIVVITLDAHLHSPMYFFLKNLSFLDLCYSSIIAPKALANFLSSSKVITFKGCATQFFFFSMMGTTEAFLLAVMAYDRFMAICSPLLYPITMYPSVCACLVLGSYCGGCFNSILQTSFTFSLPFCSSNHINHFFCDVVPLLQLTCANTAINKLVMFGLCGLIIVGTTLMVLVSYGYITLTILRMHSGGGRHKLFSTCGSHMTAVSLFYGTVFVMYAQPGAVQSMEQGKVVSVFYTLVIPMLNPLIYSLRNKDVKDALRRLIQKHIAT", "length": 316, "header": "tr|A0AAA9SQ51-1|A0AAA9SQ51_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9S36 PE=3 SV=1 CANONICAL=A0AAA9SQ51-1" }, "locus": { "chromosome": "3", "start_pos": 119621368, "end_pos": 119620421, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132446.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132446.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085059.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112446047", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112446047", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ51" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 295, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 47, "end_pos": 49 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ55-1", "uniprot_ac": "A0AAA9SQ55", "uniprot_id": "A0AAA9SQ55_BOVIN", "mass": { "chemical_mass": 70217.0, "monoisotopic_mass": 70217.0 }, "refseq": {}, "gene_names": [ { "name": "PAPSS2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" } ] } ], "protein_names": [ { "name": "3'-phosphoadenosine 5'-phosphosulfate synthase 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAPSS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55", "locus": { "chromosome": "26", "start_pos": 9370521, "end_pos": 9258640, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003196", "url": "https://www.ensembl.org/id/ENSBTAG00000003196" } ] } } ], "crossref": [ { "id": "A0AAA9SQ55", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ55", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003196", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003196", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00517", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00517", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02027", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02027", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11055", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11055", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11055:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11055:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01747", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01747", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14306", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14306", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N085", "url": "https://www.uniprot.org/uniprotkb/F1N085", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N085-1", "url": "https://www.uniprot.org/uniprotkb/F1N085-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPHPEKGPEENQQKSTNIVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNIRQGLNKNLGFSTWDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESSGLPFFEIFVDAPLNICERRDVKGLYKRARAGEIKGFTGIDSDYEKPESPELVLKTNLSSVSDCMQQVVELLQEQNIVPHTVIKGIHELFVPENKLDQVRAEAEALPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVVHFGTLIDGMFLPDGVINMSIPIVLPISADDKTRLEGCSKFVLTHGGRRVAILEDPEFYEHRKEERCSHVWGTTCAKHPYIKMVMESGDWLVGGDLQVLERIQWNDGLDQYRLTPLELKQKCKEMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEEVLDPKSTIVAIFPSPMLYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETKRDLYEPTHGGKVLTMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPERHDEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYASLEKNN", "length": 621, "header": "tr|A0AAA9SQ55-1|A0AAA9SQ55_BOVIN Isoform 1 of 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Bos taurus OX=9913 GN=PAPSS2 PE=3 SV=2 CANONICAL=A0AAA9SQ55-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55/entry#A0AAA9SQ55-1", "sequence": { "sequence": "MGPHPEKGPEENQQKSTNIVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNIRQGLNKNLGFSTWDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESSGLPFFEIFVDAPLNICERRDVKGLYKRARAGEIKGFTGIDSDYEKPESPELVLKTNLSSVSDCMQQVVELLQEQNIVPHTVIKGIHELFVPENKLDQVRAEAEALPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVVHFGTLIDGMFLPDGVINMSIPIVLPISADDKTRLEGCSKFVLTHGGRRVAILEDPEFYEHRKEERCSHVWGTTCAKHPYIKMVMESGDWLVGGDLQVLERIQWNDGLDQYRLTPLELKQKCKEMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEEVLDPKSTIVAIFPSPMLYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETKRDLYEPTHGGKVLTMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPERHDEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYASLEKNN", "length": 621, "header": "tr|A0AAA9SQ55-1|A0AAA9SQ55_BOVIN Isoform 1 of 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Bos taurus OX=9913 GN=PAPSS2 PE=3 SV=2 CANONICAL=A0AAA9SQ55-1" }, "locus": { "chromosome": "26", "start_pos": 9370503, "end_pos": 9259023, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135005.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135005.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087503.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087503.2" } ] } }, { "isoform_ac": "F1N085-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55/entry#F1N085-1", "sequence": { "sequence": "MSEVKKQKTENQQKSTNIVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNIRQGLNKNLGFSTWDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESSGLPFFEIFVDAPLNICERRDVKGLYKRARAGEIKGFTGIDSDYEKPESPELVLKTNLSSVSDCMQQVVELLQEQNIVPHTVIKGIHELFVPENKLDQVRAEAEALPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVVHFGTLIDGMFLPDGVINMSIPIVLPISADDKTRLEGCSKFVLTHGGRRVAILEDPEFYEHRKEERCSHVWGTTCAKHPYIKMVMESGDWLVGGDLQVLERIQWNDGLDQYRLTPLELKQKCKEMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEEVLDPKSTIVAIFPSPMLYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETKRDLYEPTHGGKVLTMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPERHDEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYASLEKNN", "length": 620, "header": "tr|F1N085-1|F1N085_BOVIN Computationally mapped isoform of 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Bos taurus OX=9913 GN=PAPSS2 PE=3 SV=5 CANONICAL=A0AAA9SQ55-1" }, "locus": { "chromosome": "26", "start_pos": 9370503, "end_pos": 9258735, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004152.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004152.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004152.8", "url": "https://www.ensembl.org/id/ENSBTAP00000004152.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" } ], "pmid": "" }, { "name": "adenylylsulfate kinase activity", "id": "GO:0004020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" } ], "pmid": "" }, { "name": "sulfate adenylyltransferase (ATP) activity", "id": "GO:0004781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sulfate assimilation", "id": "GO:0000103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000103", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" }, { "id": "PF01583", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01583" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "APS kinase", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 194, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" }, { "id": "PF14306", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14306" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ATP-sulfurylase PUA-like", "eco_id": "ECO_0000259", "start_pos": 224, "end_pos": 382, "start_aa": "Gly", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ55" }, { "id": "PF01747", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01747" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulphate adenylyltransferase catalytic", "eco_id": "ECO_0000259", "start_pos": 390, "end_pos": 612, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ71-1", "uniprot_ac": "A0AAA9SQ71", "uniprot_id": "A0AAA9SQ71_BOVIN", "mass": { "chemical_mass": 114104.0, "monoisotopic_mass": 114104.0 }, "refseq": {}, "gene_names": [ { "name": "PXN", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ] } ], "protein_names": [ { "name": "Paxillin", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PXN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71", "locus": { "chromosome": "17", "start_pos": 62565636, "end_pos": 62607957, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018108", "url": "https://www.ensembl.org/id/ENSBTAG00000018108" } ] } } ], "crossref": [ { "id": "A0AAA9SQ71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018108", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018108", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09336", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09336", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09338", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09338", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09407", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09407", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09409", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09409", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09411", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09411", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517456", "url": "https://www.ncbi.nlm.nih.gov/gene/517456", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517456", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517456", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTGPHYV", "url": "https://omabrowser.org/oma/group/MTGPHYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1X1", "url": "https://www.orthodb.org/?gene=A0A3Q1M1X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24216:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24216:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M1X1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1X1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1X1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPVPPPPSSEALNGSVLDPLDPWPPSTSRFTHQQPQSSSPVYGSSAKTSSASNPQDGGGPPCPRAGEEDHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGPLSTHYGVPENNSLLGGKAGALTKEKPKRNGGRGLEDLRPSVENLLDELESSVPSPVPTITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKTSSSSAVALSSSGLPPGSAPSSHHSLSPPPPAGSSGGLPPPRKPSPQGHSHTLGVLCAGQVAPGQLDLAGFGVMPDTPNSRFPSTEGWPGLLSVESQAHVWRDPPDLVEELCRVPPGHILPYPGGTGPQDPGAPQAPLANALHPEEAVAATWQGPWALGVLKPEPPQGAAPNFQEVTEPAVVAVDRQAVFPDTWSLTEERGCQERARPEPGAPESGRHTPVEDEQLGGETPLAGGLVRPARGPETPRRPEGTTEVTTEARMDRPELPRAVAVDMPSTTERISTSSQIRSVIRRSRETGHAHPMSREPSPRRRLDPATLSRTPSQERLITELQGRLGIRPEAEEATGAAGASTEDWLTEGVVITVQPRGRRAGGQLVEKVVFPPGSPIPLRRTFSVLPSPLPPPSPLLQHRKDASSASSSPPLPSPPTPCGPSGVQSTGTGPQGVGVQGPAPCVAAPRSVRSIGCQTDEDPLFPPMQIQDLEQRADGELCWAAGWPLNGRQSGPEGQDMGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVHGSFFEHEGQPYCEAHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC", "length": 1066, "header": "tr|A0AAA9SQ71-1|A0AAA9SQ71_BOVIN Isoform 1 of Paxillin OS=Bos taurus OX=9913 GN=PXN PE=1 SV=1 CANONICAL=A0AAA9SQ71-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1X1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71/entry#A0A3Q1M1X1-1", "sequence": { "sequence": "MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPVPPPPSSEALNGSVLDPLDPWPPSTSRFTHQQPQSSSPVYGSSAKTSSASNPQDGGGPPCPRAGEEDHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGPLSTHYGVPENNSLLGGKAGALTKEKPKRNGGRGLEDLRPSVENLLDELESSVPSPVPTITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVHGSFFEHEGQPYCEAHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC", "length": 556, "header": "tr|A0A3Q1M1X1-1|A0A3Q1M1X1_BOVIN Computationally mapped isoform of Paxillin OS=Bos taurus OX=9913 GN=PXN PE=1 SV=1 CANONICAL=A0AAA9SQ71-1" }, "locus": { "chromosome": "17", "start_pos": 62607653, "end_pos": 62566640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072658.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072658.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067366.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067366.1" } ] } }, { "isoform_ac": "A0AAA9SQ71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71/entry#A0AAA9SQ71-1", "sequence": { "sequence": "MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPVPPPPSSEALNGSVLDPLDPWPPSTSRFTHQQPQSSSPVYGSSAKTSSASNPQDGGGPPCPRAGEEDHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGPLSTHYGVPENNSLLGGKAGALTKEKPKRNGGRGLEDLRPSVENLLDELESSVPSPVPTITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKTSSSSAVALSSSGLPPGSAPSSHHSLSPPPPAGSSGGLPPPRKPSPQGHSHTLGVLCAGQVAPGQLDLAGFGVMPDTPNSRFPSTEGWPGLLSVESQAHVWRDPPDLVEELCRVPPGHILPYPGGTGPQDPGAPQAPLANALHPEEAVAATWQGPWALGVLKPEPPQGAAPNFQEVTEPAVVAVDRQAVFPDTWSLTEERGCQERARPEPGAPESGRHTPVEDEQLGGETPLAGGLVRPARGPETPRRPEGTTEVTTEARMDRPELPRAVAVDMPSTTERISTSSQIRSVIRRSRETGHAHPMSREPSPRRRLDPATLSRTPSQERLITELQGRLGIRPEAEEATGAAGASTEDWLTEGVVITVQPRGRRAGGQLVEKVVFPPGSPIPLRRTFSVLPSPLPPPSPLLQHRKDASSASSSPPLPSPPTPCGPSGVQSTGTGPQGVGVQGPAPCVAAPRSVRSIGCQTDEDPLFPPMQIQDLEQRADGELCWAAGWPLNGRQSGPEGQDMGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVHGSFFEHEGQPYCEAHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC", "length": 1066, "header": "tr|A0AAA9SQ71-1|A0AAA9SQ71_BOVIN Isoform 1 of Paxillin OS=Bos taurus OX=9913 GN=PXN PE=1 SV=1 CANONICAL=A0AAA9SQ71-1" }, "locus": { "chromosome": "17", "start_pos": 62607653, "end_pos": 62566640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115850.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115850.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088475.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 703, "start_aa": "Thr", "end_pos": 703, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr703", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517456", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517456", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7FWV4-1", "protein_name": "Paxillin", "gene_name": "Pxn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWKLQVSSPIEAADALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQETAVPPPVPPPPSSEALNGTILDPLDQWQPSGSRYTHQQPPSPSPVYSSSAKTSGASNPQDSALCSRAGEEEHVYSFPNKHKSAEPSPTMMSSSLGNNLSELDRLLLELNAVQHNPSGFPADEANSSPPLPGALSPLYGVPESNSTLGGKTGPLMKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKMHGLEQRVDGERQWAAGWPPSSRQSSPEGQDEGGFMAQGKTGSSPPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFLKLFC", "length": 598 }, "evidence": [ { "id": "A0AAA9SQ71", "url": "https://omabrowser.org/oma/group/A0AAA9SQ71/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ71" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 831, "end_pos": 890, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 703 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ80-1", "uniprot_ac": "A0AAA9SQ80", "uniprot_id": "A0AAA9SQ80_BOVIN", "mass": { "chemical_mass": 63574.0, "monoisotopic_mass": 63574.0 }, "refseq": { "ac": "NP_001179093", "name": "zinc finger and BTB domain-containing protein 46", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179093" }, "gene_names": [ { "name": "ZBTB46", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ] }, { "name": "ZBTB46", "type": "synonym", "evidence": [ { "id": "NP_001179093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179093" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 46", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 46", "type": "synonym", "evidence": [ { "id": "NP_001179093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179093" } ] } ], "function": [ { "annotation": "Transcription regulator that mediates differentiation of conventional and non-conventional dendritic cells, and which is involved in tolerance to gut microbiota. Together with RORgammaT (RORC), specifically expressed in type 3 innate lymphoid cells (ILC3s) that are required for tolerance to gut microbiota, to mediate differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms. Functions as a transcription corepressor for PRDM1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80#function" }, { "database": "UniProtKB", "id": "ARBA00094402", "url": "https://www.uniprot.org/uniprotkb/ARBA00094402#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80", "locus": { "chromosome": "13", "start_pos": 54027412, "end_pos": 53979418, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016667", "url": "https://www.ensembl.org/id/ENSBTAG00000016667" } ] } } ], "crossref": [ { "id": "A0AAA9SQ80", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ80", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18230", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18230", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507985", "url": "https://www.ncbi.nlm.nih.gov/gene/507985", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507985", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507985", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WPADSGM", "url": "https://omabrowser.org/oma/group/WPADSGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179093", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNRKEDMEIASHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKPDASDELEAFEVGAPPGGGADALISAVMAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDQEPKTEGPDDLASQPLWPGDVGCGPLHVKEEPLSPAHYGGSEPPSAMDGTIQNSFSEQTAGDGWQPTGRRKNRKNKDTVRHITQQVEEDSRAGSPLPSFLPTSGWPFSSRDSNADLTIAEASSSDSRGERPEFLAHVDEGLLGGEGSYLGAPLTPEKDDALHQATAVANLRAALMSKNSLLALKADVLGEDSSLLLEYLPKGAHSLSLNEFTVIRKKFRCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKLCSRVFMSAASVGIKHGSRRHGVCADCAGGGGAGSLDGGGAEGSPELFAGDGPYLEDPEDPRGEGEEELGEDEDDVGLAPEDTLLGDKEDDDSPRGPHSPTGGADKDFAWIS", "length": 589, "header": "tr|A0AAA9SQ80-1|A0AAA9SQ80_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 46 OS=Bos taurus OX=9913 GN=ZBTB46 PE=4 SV=1 CANONICAL=A0AAA9SQ80-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80/entry#A0AAA9SQ80-1", "sequence": { "sequence": "MNNRKEDMEIASHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKPDASDELEAFEVGAPPGGGADALISAVMAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDQEPKTEGPDDLASQPLWPGDVGCGPLHVKEEPLSPAHYGGSEPPSAMDGTIQNSFSEQTAGDGWQPTGRRKNRKNKDTVRHITQQVEEDSRAGSPLPSFLPTSGWPFSSRDSNADLTIAEASSSDSRGERPEFLAHVDEGLLGGEGSYLGAPLTPEKDDALHQATAVANLRAALMSKNSLLALKADVLGEDSSLLLEYLPKGAHSLSLNEFTVIRKKFRCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKLCSRVFMSAASVGIKHGSRRHGVCADCAGGGGAGSLDGGGAEGSPELFAGDGPYLEDPEDPRGEGEEELGEDEDDVGLAPEDTLLGDKEDDDSPRGPHSPTGGADKDFAWIS", "length": 589, "header": "tr|A0AAA9SQ80-1|A0AAA9SQ80_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 46 OS=Bos taurus OX=9913 GN=ZBTB46 PE=4 SV=1 CANONICAL=A0AAA9SQ80-1" }, "locus": { "chromosome": "13", "start_pos": 54027308, "end_pos": 53999130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131237.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131237.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088485.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088485.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507985", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507985", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B3S2-1", "protein_name": "Zinc finger and BTB domain-containing protein 46", "gene_name": "ZBTB46", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSNRKEDMEIASHYRQLLRELDEQRQHGVLCDACVVVEGKVFRAHKNVLLGSSRYFKTLYCQVQKPSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKPDASDELAEFEVGAPPGGGADALISAVMAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDQEPKADGPDDLPSQPLWPGDAAYGPLRIKEEQLSPAHYGAGEPPSARDGVTPSFAEQAAGDGWQPAGRRKNRKNKETVRHITPQVEDDSRAGSPAPSFLPAAAWPFGSRDSNADLTVAEAGSSDSRGERPELFAHMDEGLLGGEASYLGPPLTPEKDDVLPQATAVANLRAALRSKNSLLSLKADVLGEDSSLLLEYLPQGTHSLSLNEFTVIRKKFRCPYCSFSAMHQCILKRHMRSHTGERPYPCDICGKKFTRREHMKRHTLVHSKDKKYVCKLCSRVFMSAASVGIKHGSRRHGVCADCAGGGGAGPLDGGGTEGSPELFAGDGQYLEDPEDPRGEGEEELGEEEDDVGLAHEDALLGDDKEDEDSPRGPRSPAGGHDKDFAWIS", "length": 589 }, "evidence": [ { "id": "A0AAA9SQ80", "url": "https://omabrowser.org/oma/group/A0AAA9SQ80/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3Q2U2W3-1", "protein_name": "Zinc finger and BTB domain-containing protein 46", "gene_name": "ZBTB46", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSAAAGEAPELEPSLLLDLWKRKHKDFQMNNRKEDMEIASHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASYLQMTDIVQACHNFIKAALDISIKSDASDDLVDYELGAPSSSSTDALISAVVAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDPEPKTDSHEDVSSQSLWSSDMGYGSLRIKEEQVSPSHYGGSELHSAKDSAIQNAFSEQGVGDGWQPTGRRKNRKNKETVRHITQQVEDDSRASSPMPSFLPASGWPYSSRDPSADVTAAEPSSSDSRGERPDPFAHTEEQLLGAGEGSYLPQPPLDREDALQAATVANLRAALMSKNSLLSLKADVLGDDSSLLFEYLPKGTHSLSRPGTNWSRSRGECDGKVEAASPPLPAAHLATQSPPASCSSGDMSPEATAKGELPSSTQAAYDGFLALWPFDNSDSDVCLRSEDTDVTHDGLFSDPALPKGLTCGFCRRVFERAEELQEHIHVHIYQHEAALSLLLPLDARTRPGLLGTVPPSRFQCAQCPASFTLKSNMDRHEKTIHFNFNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCNRVFMSAASVGIKHGSRRHGVCADCSGRGMAGHLEPSGAEGSPEELYPGEGSYMEDPDDIKVEGDEEMGDDDDIKWKDDVGMAHDDVILDDDKDVDSSQENSGENDKDFTWIS", "length": 799 }, "evidence": [ { "id": "A0AAA9SQ80", "url": "https://omabrowser.org/oma/group/A0AAA9SQ80/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZTY1-1", "protein_name": "Zinc finger and BTB domain-containing protein 46", "gene_name": "Zbtb46", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELSEFEIGTPASNSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDQEPKADGPDDVSSQSLWPGDVGYGSLRIKEEQISPSHYGGSELSSSKDAAIQNSLSEQGSGDGWQPTGRRKNRKNKETVRHITQQVEEDSQAGSPVPSFLPTSGWPFSSRDSNVDLTVTEASSLDSRGERAELYAHHIDEGLLGGETSYLGPPLTPEKEEALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPKGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIKHGSRRHGVCADCAGRGVGTPLDHGGGGEGSPEALFAGEGPYLEDPDDPRGEVEEELGEDEDEDVAKWKDDVGLAHEDALLGDDKDDEDSPQGPHSPAGEPDKDFAWIS", "length": 601 }, "evidence": [ { "id": "A0AAA9SQ80", "url": "https://omabrowser.org/oma/group/A0AAA9SQ80/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86UZ6-1", "protein_name": "Zinc finger and BTB domain-containing protein 46", "gene_name": "ZBTB46", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQPLWPGDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVRHITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDALLADDKDEEDSPRPRSPPGGPDKDFAWLS", "length": 589 }, "evidence": [ { "id": "A0AAA9SQ80", "url": "https://omabrowser.org/oma/group/A0AAA9SQ80/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BID6-1", "protein_name": "Zinc finger and BTB domain-containing protein 46", "gene_name": "Zbtb46", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELSEFEIGTPASNSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDQEPKADGPDDVSSQSLWPGDVGYGSLRIKEEQISPSHYGGSELPSSKDTAIQNSLSEQGSGDGWQPTGRRKNRKNKETVRHITQQVEEDSQAGSPVPSFLPTSGWPFSSRDSNVDLTVTEASSLDSRGERAELYAHIDEGLLGGETSYLGPPLTPEKEEALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPKGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIKHGSRRHGVCADCAGRGVGTPLDHGGGGEGSPEALFAGEGPYLEDPDDPRGEAEEELVEDEDEDVAKWKDDVGLAHEDALLGDDKDDEDSPQGPHSPSGEPDKDFAWIS", "length": 600 }, "evidence": [ { "id": "A0AAA9SQ80", "url": "https://omabrowser.org/oma/group/A0AAA9SQ80/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" }, { "name": "regulatory T cell differentiation", "id": "GO:0045066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" }, { "name": "tolerance induction in gut-associated lymphoid tissue", "id": "GO:0002394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002394", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 99, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQ80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ80" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 418, "end_pos": 445, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ86-1", "uniprot_ac": "A0AAA9SQ86", "uniprot_id": "A0AAA9SQ86_BOVIN", "mass": { "chemical_mass": 86827.0, "monoisotopic_mass": 86827.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Cadherin 19", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cadherins are calcium-dependent cell adhesion proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86#function" }, { "database": "UniProtKB", "id": "RU004357", "url": "https://www.uniprot.org/uniprotkb/RU004357#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86", "locus": {} } ], "crossref": [ { "id": "A0AAA9SQ86", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ86", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027:SF323", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027:SF323", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNCWLLLPFMLGIPLLWPCIIAAENSKTEEVRHPAGSRLRIRRGWMWNQFFVPEEMNKTRHHIGQLRSDLDNGNNSFQYKLLGVGAESLFVIDERTGDIYAVQKLDREERSLYTLRAQVIDTTTGRAVEPESEFVIRVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLVYSLLQGQPYFSIEPTTGKIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVNDNKPIFKDSLYRLTVSESAPVGTSIGKIMAYDRDIGENAEMDYSIEDDSRTFDVITNNETQEGIIILKKKVNFEDQNHYRIRAKVKNPQVDAHLREYHTEASTTVIKIQVEDVDEPPVFLLPYYIFEIFEECPHGSSVGTVSATDPDQRKSPIGYSITRSEVFSVDDNGTIFTTNPLDRETSAWYNLSVTATEKYNIAQISSVPVYVQVLNINDHAPEFSEYYETYVCENAVSGQVIQTISAVDRDESIEHHHFYFNLSMEENNSSFAIIDNQDNTAVILTNRTGFSLQEEPVFYIAILIADNGIPSLTSTNTLTVHVCDCGDADSTQTCSHKDFMLSMGFKAEVITAILICIMIIFGFIFLNLGLKQRRKQTLFPEKSEEFRENIFRYDDEGGGEADTEAFDIAQLRGSAVMRGRKPRRPARAEMRSLYRQSLQVGPDSAVFRKFILEKLEEADTDPCAPPFDSLQTYAFEGTGSSAGSLSSLDSAVSDHDENYDYLNELGPRFKRLAYMFGSAMQSKN", "length": 770, "header": "tr|A0AAA9SQ86-1|A0AAA9SQ86_BOVIN Isoform 1 of Cadherin 19 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SQ86-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86/entry#A0AAA9SQ86-1", "sequence": { "sequence": "MNCWLLLPFMLGIPLLWPCIIAAENSKTEEVRHPAGSRLRIRRGWMWNQFFVPEEMNKTRHHIGQLRSDLDNGNNSFQYKLLGVGAESLFVIDERTGDIYAVQKLDREERSLYTLRAQVIDTTTGRAVEPESEFVIRVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLVYSLLQGQPYFSIEPTTGKIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVNDNKPIFKDSLYRLTVSESAPVGTSIGKIMAYDRDIGENAEMDYSIEDDSRTFDVITNNETQEGIIILKKKVNFEDQNHYRIRAKVKNPQVDAHLREYHTEASTTVIKIQVEDVDEPPVFLLPYYIFEIFEECPHGSSVGTVSATDPDQRKSPIGYSITRSEVFSVDDNGTIFTTNPLDRETSAWYNLSVTATEKYNIAQISSVPVYVQVLNINDHAPEFSEYYETYVCENAVSGQVIQTISAVDRDESIEHHHFYFNLSMEENNSSFAIIDNQDNTAVILTNRTGFSLQEEPVFYIAILIADNGIPSLTSTNTLTVHVCDCGDADSTQTCSHKDFMLSMGFKAEVITAILICIMIIFGFIFLNLGLKQRRKQTLFPEKSEEFRENIFRYDDEGGGEADTEAFDIAQLRGSAVMRGRKPRRPARAEMRSLYRQSLQVGPDSAVFRKFILEKLEEADTDPCAPPFDSLQTYAFEGTGSSAGSLSSLDSAVSDHDENYDYLNELGPRFKRLAYMFGSAMQSKN", "length": 770, "header": "tr|A0AAA9SQ86-1|A0AAA9SQ86_BOVIN Isoform 1 of Cadherin 19 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SQ86-1" }, "locus": { "chromosome": "24", "start_pos": 10216087, "end_pos": 10163624, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086156.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086156.1" } ] } }, { "isoform_ac": "A0AAA9TXL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86/entry#A0AAA9TXL7-1", "sequence": { "sequence": "MNCWLLLPFMLGIPLLWPCIIAAENSKTEEVRHPAGSRLRIRRGWMWNQFFVPEEMNKTRHHIGQLRSDLDNGNNSFQYKLLGVGAESLFVIDERTGDIYAVQKLDREERSLYTLRAQVIDTTTGRAVEPESEFVIRVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLVYSLLQGQPYFSIEPTTGKIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVNDNKPIFKDSLYRLTVSESAPVGTSIGKIMAYDRDIGENAEMDYSIEDDSRTFDVITNNETQEGIIILKKKVNFEDQNHYRIRAKVKNPQVDAHLREYHTEASTTVIKIQVEDVDEPPVFLLPYYIFEIFEECPHGSSVGTVSATDPDQRKSPIGYSITRSEVFSVDDNGTIFTTNPLDRETSAWYNLSVTATEKYNIAQISSVPVYVQVLNINDHAPEFSEYYETYVCENAVSGQGLFF", "length": 489, "header": "tr|A0AAA9TXL7-1|A0AAA9TXL7_BOVIN Computationally mapped isoform of Cadherin 19 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SQ86-1" }, "locus": { "chromosome": "24", "start_pos": 10215611, "end_pos": 10163624, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124931.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124931.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103078.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103078.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 507, "end_pos": 509, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ86" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 148, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 507, "end_pos": 509 }, { "start_pos": 513, "end_pos": 515 }, { "start_pos": 514, "end_pos": 516 }, { "start_pos": 532, "end_pos": 534 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQB4-1", "uniprot_ac": "A0AAA9SQB4", "uniprot_id": "A0AAA9SQB4_BOVIN", "mass": { "chemical_mass": 97307.0, "monoisotopic_mass": 97307.0 }, "refseq": { "ac": "XP_024850768", "name": "semaphorin-6B isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850768" }, "gene_names": [ { "name": "SEMA6B", "type": "recommended", "evidence": [ { "id": "A0AAA9SQB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ] }, { "name": "SEMA6B", "type": "synonym", "evidence": [ { "id": "XP_024850768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850768" } ] } ], "protein_names": [ { "name": "Semaphorin-6B", "type": "recommended", "evidence": [ { "id": "A0AAA9SQB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4/entry#names_and_taxonomy" } ] }, { "name": "semaphorin-6B isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024850768", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850768" } ] } ], "function": [ { "annotation": "Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.", "evidence": [ { "database": "UniProtKB", "id": "E1BIT8", "url": "https://www.uniprot.org/uniprotkb/E1BIT8#function" }, { "database": "UniProtKB", "id": "ARBA00056706", "url": "https://www.uniprot.org/uniprotkb/ARBA00056706#function" }, { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEMA6B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4", "locus": { "chromosome": "7", "start_pos": 19585528, "end_pos": 19555022, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031658", "url": "https://www.ensembl.org/id/ENSBTAG00000031658" } ] } } ], "crossref": [ { "id": "A0AAA9SQB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031658", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031658", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11267", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11267", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527573", "url": "https://www.ncbi.nlm.nih.gov/gene/527573", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527573", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527573", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BIT8", "url": "https://www.orthodb.org/?gene=E1BIT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024850768", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850768", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIT8", "url": "https://www.uniprot.org/uniprotkb/E1BIT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIT8-1", "url": "https://www.uniprot.org/uniprotkb/E1BIT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRQRDVPRNTLGVTSCRPDLAMRTPRGPPSRPALLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTPSEDADDLNIQRVLRVNRTLFIGGRDNLYRVELEPPTSTEMRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSMDTLQPLRDNISGMARCPYDPKHANVALFSEGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHIYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSAFPDEILNFVKTHPLMDEAVPSLGHAPWIVRTLMRHQLTRVAVDVGAGPWGNQTVIFLGSEAGTVLKFLVWPNASASGTTGPSVFLEEFETYRPDRCGRSGDGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCVFLSPGTRATFEQDVSGTSTSGLGDCTGLLRASLSEERAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWYVGLRERRELARRKDKEAILAHGGGEAVLSVSRLGERRAGGPGGRAGGGGGGPGGPPEALLAPLMQNGWTKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHTLGPRAWEHGPALLTASASSSLLLLAPGRAPEPPPAPGEPAAPDARLFTARPGRASHGDFPLTPHASPDRRRVVSAPTGPSDPSSSTDGFPRPWSPPPTGSLRRPGAHAPPAAALRRTHTINSGEARPRGRHARPVTDLAHLLSYGGPDRTAPPVP", "length": 903, "header": "tr|A0AAA9SQB4-1|A0AAA9SQB4_BOVIN Isoform 1 of Semaphorin-6B OS=Bos taurus OX=9913 GN=SEMA6B PE=3 SV=1 CANONICAL=A0AAA9SQB4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4/entry#A0AAA9SQB4-1", "sequence": { "sequence": "MRQRDVPRNTLGVTSCRPDLAMRTPRGPPSRPALLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTPSEDADDLNIQRVLRVNRTLFIGGRDNLYRVELEPPTSTEMRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSMDTLQPLRDNISGMARCPYDPKHANVALFSEGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHIYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSAFPDEILNFVKTHPLMDEAVPSLGHAPWIVRTLMRHQLTRVAVDVGAGPWGNQTVIFLGSEAGTVLKFLVWPNASASGTTGPSVFLEEFETYRPDRCGRSGDGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCVFLSPGTRATFEQDVSGTSTSGLGDCTGLLRASLSEERAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWYVGLRERRELARRKDKEAILAHGGGEAVLSVSRLGERRAGGPGGRAGGGGGGPGGPPEALLAPLMQNGWTKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHTLGPRAWEHGPALLTASASSSLLLLAPGRAPEPPPAPGEPAAPDARLFTARPGRASHGDFPLTPHASPDRRRVVSAPTGPSDPSSSTDGFPRPWSPPPTGSLRRPGAHAPPAAALRRTHTINSGEARPRGRHARPVTDLAHLLSYGGPDRTAPPVP", "length": 903, "header": "tr|A0AAA9SQB4-1|A0AAA9SQB4_BOVIN Isoform 1 of Semaphorin-6B OS=Bos taurus OX=9913 GN=SEMA6B PE=3 SV=1 CANONICAL=A0AAA9SQB4-1" }, "locus": { "chromosome": "7", "start_pos": 19584524, "end_pos": 19557284, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086140.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086140.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085126.1" } ] } }, { "isoform_ac": "E1BIT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4/entry#E1BIT8-1", "sequence": { "sequence": "MWTLGCSHPLSGGCCGEDRLCRDNLYRVELEPPTSTEMRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSMDTLQPLRDNISGMARCPYDPKHANVALFSEGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHIYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSAFPDEILNFVKTHPLMDEAVPSLGHAPWIVRTLMRHQLTRVAVDVGAGPWGNQTVIFLGSEAGTVLKFLVWPNASASGTTGPSVFLEEFETYRPDRCGRSGDGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCVFLSPGTRATFEQDVSGTSTSGLGDCTGLLRASLSEERAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWYVGLRERRELARRKDKEAILAHGGGEAVLSVSRLGERRAGGPGGRAGGGGGGPGGPPEALLAPLMQNGWTKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHTLGPRAWEHGPALLTASASSSLLLLAPGRAPEPPPAPGEPAAPDARLFTARPGRASHGDFPLTPHASPDRRRVVSAPTGPSDPSSSTDGFPRPWSPPPTGSLRRPGAHAPPAAALRRTHTINSGEARPRGRHARPVTDLAHLLSYGGPDRTAPPVP", "length": 822, "header": "tr|E1BIT8-1|A0AAA9SQB4_BOVIN Computationally mapped isoform of Semaphorin-6B OS=Bos taurus OX=9913 GN=SEMA6B PE=3 SV=4 CANONICAL=A0AAA9SQB4-1" }, "locus": { "chromosome": "7", "start_pos": 19584524, "end_pos": 19574180, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003619.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003619.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003619.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003619.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527573", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527573", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "hippocampus development", "id": "GO:0021766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021766", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQB4" }, { "id": "PS51004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sema", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 544, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 462, "end_pos": 464 }, { "start_pos": 483, "end_pos": 485 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQG6-1", "uniprot_ac": "A0AAA9SQG6", "uniprot_id": "A0AAA9SQG6_BOVIN", "mass": { "chemical_mass": 38879.0, "monoisotopic_mass": 38879.0 }, "refseq": {}, "gene_names": [ { "name": "FLT3LG", "type": "recommended", "evidence": [ { "id": "A0AAA9SQG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6" } ] } ], "protein_names": [ { "name": "Fms related receptor tyrosine kinase 3 ligand", "type": "synonym", "evidence": [ { "id": "A0AAA9SQG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FLT3LG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6", "locus": { "chromosome": "18", "start_pos": 55939491, "end_pos": 55930015, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038045", "url": "https://www.ensembl.org/id/ENSBTAG00000038045" } ] } } ], "crossref": [ { "id": "A0AAA9SQG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR004213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11032", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11032", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11032:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11032:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02947", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02947", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM84", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM84-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVLAPAWSPTTSLLLLLLLLSPGLQGTPDCSFRHSPISSTFAIKIGKLSKYLLQDYPVTVASNLQDVSHRREGPRMEVGRRNSRFTAPLGARLVCPPGHPLPGDPGVLAPSPLRPPAGPRAWVVSPQDKLCGAFWRLVLAQRWMGRLKTVAGSEMEKLLEDVNTEIHFVTSCAFQPLPSCLRFVQANISHLLQDTHQQLEALKPWITHRNFSRCLELQCQPDSPTLLPPRSPGALGATSLPGPQSPLLLLLLLLLLPVALLLLATAWCLCRWRRRRRTRYPGERRRTLRPRESSHLPADTESELGGSQLEPGPFLGHPAPVTVPPGWRQRQHPPSAPPSPLCTKPLSPGNCI", "length": 353, "header": "tr|A0AAA9SQG6-1|A0AAA9SQG6_BOVIN Isoform 1 of Fms related receptor tyrosine kinase 3 ligand OS=Bos taurus OX=9913 GN=FLT3LG PE=4 SV=1 CANONICAL=A0AAA9SQG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6/entry#A0AAA9SQG6-1", "sequence": { "sequence": "MVVLAPAWSPTTSLLLLLLLLSPGLQGTPDCSFRHSPISSTFAIKIGKLSKYLLQDYPVTVASNLQDVSHRREGPRMEVGRRNSRFTAPLGARLVCPPGHPLPGDPGVLAPSPLRPPAGPRAWVVSPQDKLCGAFWRLVLAQRWMGRLKTVAGSEMEKLLEDVNTEIHFVTSCAFQPLPSCLRFVQANISHLLQDTHQQLEALKPWITHRNFSRCLELQCQPDSPTLLPPRSPGALGATSLPGPQSPLLLLLLLLLLPVALLLLATAWCLCRWRRRRRTRYPGERRRTLRPRESSHLPADTESELGGSQLEPGPFLGHPAPVTVPPGWRQRQHPPSAPPSPLCTKPLSPGNCI", "length": 353, "header": "tr|A0AAA9SQG6-1|A0AAA9SQG6_BOVIN Isoform 1 of Fms related receptor tyrosine kinase 3 ligand OS=Bos taurus OX=9913 GN=FLT3LG PE=4 SV=1 CANONICAL=A0AAA9SQG6-1" }, "locus": { "chromosome": "18", "start_pos": 55939472, "end_pos": 55930045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134268.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134268.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087603.1" } ] } }, { "isoform_ac": "A0ABI0NM84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6/entry#A0ABI0NM84-1", "sequence": { "sequence": "MVVLAPAWSPTTSLLLLLLLLSPGLQGTPDCSFRHSPISSTFAIKIGKLSKYLLQDYPVTVASNLQDDKLCGAFWRLVLAQRWMGRLKTVAGSEMEKLLEDVNTEIHFVTSCAFQPLPSCLRFVQANISHLLQDTHQQLEALKPWITHRNFSRCLELQCQPAEDTEAQREQSPASGHRVGTWRKSARTWSFPWPPCSCHCPPGMEATPAPTIGSPFPTLYKALVPRKLYINHHFLP", "length": 236, "header": "tr|A0ABI0NM84-1|A0ABI0NM84_BOVIN Computationally mapped isoform of Fms-related tyrosine kinase 3 ligand OS=Bos taurus OX=9913 GN=FLT3LG PE=4 SV=1 CANONICAL=A0AAA9SQG6-1" }, "locus": { "chromosome": "18", "start_pos": 55939492, "end_pos": 55930045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151011.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151011.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106154.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106154.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of biosynthetic process", "id": "GO:0009891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 211, "end_pos": 213 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQH4-1", "uniprot_ac": "A0AAA9SQH4", "uniprot_id": "A0AAA9SQH4_BOVIN", "mass": { "chemical_mass": 33891.0, "monoisotopic_mass": 33891.0 }, "refseq": {}, "gene_names": [ { "name": "OR5T1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SQH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5T1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SQH4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "NVTEITMFILMGFTDDFEVQVFLFLLFLAIYLFTLIGNLGLVFLVIVDSRLHKPMYHFLSVLSSLDACCSSVVTPKMIVNFLVENKTISYLECITQTLLLVTFGTTECFLLAAMAYDRYVAIYNPLLYSVSMAPRVYMPLIIASYVGGIVHATVHTVATFSLSFCASNEIRHVFCDIPPLLAISCSDTHTNQLLLFYLVGSIEIVTVLIVLISYGFILLAILRMHSAEGRRKVFSTCGSHLTGVSIYHGTILFMYMRPSSSYALDHDMIVSVFYSIIIPMLNPVIYSLRNKDVKEAIKRVFG", "length": 302, "header": "tr|A0AAA9SQH4-1|A0AAA9SQH4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5T1 PE=3 SV=1 CANONICAL=A0AAA9SQH4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4/entry#A0AAA9SQH4-1", "sequence": { "sequence": "NVTEITMFILMGFTDDFEVQVFLFLLFLAIYLFTLIGNLGLVFLVIVDSRLHKPMYHFLSVLSSLDACCSSVVTPKMIVNFLVENKTISYLECITQTLLLVTFGTTECFLLAAMAYDRYVAIYNPLLYSVSMAPRVYMPLIIASYVGGIVHATVHTVATFSLSFCASNEIRHVFCDIPPLLAISCSDTHTNQLLLFYLVGSIEIVTVLIVLISYGFILLAILRMHSAEGRRKVFSTCGSHLTGVSIYHGTILFMYMRPSSSYALDHDMIVSVFYSIIIPMLNPVIYSLRNKDVKEAIKRVFG", "length": 302, "header": "tr|A0AAA9SQH4-1|A0AAA9SQH4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5T1 PE=3 SV=1 CANONICAL=A0AAA9SQH4-1" }, "locus": { "chromosome": "15", "start_pos": 78638730, "end_pos": 78637825, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123186.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123186.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086180.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1, "end_pos": 3, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH4" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 286, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1, "end_pos": 3 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQI3-1", "uniprot_ac": "A0AAA9SQI3", "uniprot_id": "A0AAA9SQI3_BOVIN", "mass": { "chemical_mass": 37187.0, "monoisotopic_mass": 37187.0 }, "refseq": {}, "gene_names": [ { "name": "IL20RB", "type": "recommended", "evidence": [ { "id": "A0AAA9SQI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3" } ] } ], "protein_names": [ { "name": "Interleukin 20 receptor subunit beta", "type": "synonym", "evidence": [ { "id": "A0AAA9SQI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL20RB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3", "locus": { "chromosome": "1", "start_pos": 132167385, "end_pos": 132207307, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008299", "url": "https://www.ensembl.org/id/ENSBTAG00000008299" } ] } } ], "crossref": [ { "id": "A0AAA9SQI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01108", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01108", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RIS1", "url": "https://www.uniprot.org/uniprotkb/F6RIS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RIS1-1", "url": "https://www.uniprot.org/uniprotkb/F6RIS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLEEIKTSLIMWFSYALIPCLFVGNLCFFDPLDPFVNLTFSSMKQSSLLRKTILNRPRDGVAVLPAPQNLSVQSTNMKHVLTWSPVTVPEEIVHYSVEYQGEYESLYTSHIWIPSIWCSPTQRPECDITEDITATVSYSLRVRATLGSLTSTWSTLKHRFNQNSTILTPPGMEITMDGFHLLIKLEDLGPHFEFFVSYWRREPGAKEHIKVVRPGVLPVYLETVEPGAAYCVKARTFREGHRAAQCLQPDRMCQGARRGPASGAGPVCLRGLHADPGGGAALRLEDGPAAPALLLPRGDAPRHLENNKFTPEVNQLQKRRGRSLCDLRALF", "length": 332, "header": "tr|A0AAA9SQI3-1|A0AAA9SQI3_BOVIN Isoform 1 of Interleukin 20 receptor subunit beta OS=Bos taurus OX=9913 GN=IL20RB PE=4 SV=1 CANONICAL=A0AAA9SQI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3/entry#A0AAA9SQI3-1", "sequence": { "sequence": "MVLEEIKTSLIMWFSYALIPCLFVGNLCFFDPLDPFVNLTFSSMKQSSLLRKTILNRPRDGVAVLPAPQNLSVQSTNMKHVLTWSPVTVPEEIVHYSVEYQGEYESLYTSHIWIPSIWCSPTQRPECDITEDITATVSYSLRVRATLGSLTSTWSTLKHRFNQNSTILTPPGMEITMDGFHLLIKLEDLGPHFEFFVSYWRREPGAKEHIKVVRPGVLPVYLETVEPGAAYCVKARTFREGHRAAQCLQPDRMCQGARRGPASGAGPVCLRGLHADPGGGAALRLEDGPAAPALLLPRGDAPRHLENNKFTPEVNQLQKRRGRSLCDLRALF", "length": 332, "header": "tr|A0AAA9SQI3-1|A0AAA9SQI3_BOVIN Isoform 1 of Interleukin 20 receptor subunit beta OS=Bos taurus OX=9913 GN=IL20RB PE=4 SV=1 CANONICAL=A0AAA9SQI3-1" }, "locus": { "chromosome": "1", "start_pos": 132207086, "end_pos": 132168248, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098153.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098153.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087619.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087619.1" } ] } }, { "isoform_ac": "F6RIS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3/entry#F6RIS1-1", "sequence": { "sequence": "MVLEEIKTSLIMWFSYALIPCLFVDGVAVLPAPQNLSVQSTNMKHVLTWSPVTVPEEIVHYSVEYQGEYESLYTSHIWIPSIWCSPTQRPECDITEDITATVSYSLRVRATLGSLTSTWSTLKHRFNQNSTILTPPGMEITMDGFHLLIKLEDLGPHFEFFVSYWRREPGAKEHIKVVRPGVLPVYLETVEPGAAYCVKARTFREGHRAAQCLQPDRMCQGARRGPASGAGPVCLRGLHADPGGGAALRLEDGPAAPALLLPRGDAPRHLENNKFTPEVNQLQKRRGRSLCDLRALF", "length": 297, "header": "tr|F6RIS1-1|F6RIS1_BOVIN Computationally mapped isoform of Interleukin 20 receptor subunit beta OS=Bos taurus OX=9913 GN=IL20RB PE=4 SV=1 CANONICAL=A0AAA9SQI3-1" }, "locus": { "chromosome": "1", "start_pos": 132207086, "end_pos": 132168248, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010919.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010919.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010919.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010919.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI3" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 67, "end_pos": 172, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 38, "end_pos": 40 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQQ0-1", "uniprot_ac": "A0AAA9SQQ0", "uniprot_id": "A0AAA9SQQ0_BOVIN", "mass": { "chemical_mass": 88430.0, "monoisotopic_mass": 88430.0 }, "refseq": {}, "gene_names": [ { "name": "STIM1", "type": "recommended", "evidence": [ { "id": "A0AAA9SQQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ] } ], "protein_names": [ { "name": "Stromal interaction molecule 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SQQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STIM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0", "locus": { "chromosome": "15", "start_pos": 51012421, "end_pos": 51216927, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013109", "url": "https://www.ensembl.org/id/ENSBTAG00000013109" } ] } } ], "crossref": [ { "id": "A0AAA9SQQ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013109", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013109", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09573", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09573", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11722", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11722", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534816", "url": "https://www.ncbi.nlm.nih.gov/gene/534816", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15136:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15136:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16533", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16533", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25578", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25578", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5578775", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5578775", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M3V5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3V5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFU0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFU0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0U2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T986", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T986", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T986-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T986-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X721", "url": "https://www.uniprot.org/uniprotkb/G3X721", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X721-1", "url": "https://www.uniprot.org/uniprotkb/G3X721-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVCARLALWLLWGLLLHHGQSLSQSHSEKATGSGANSEESTAAEFCRIDKPLCHSEDEKLSFDAVRSIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRLVEGEAGHFLTSRVSLRRMRSLSSGQSFSSEGLGTSAPPASASSSCSSATTTTTTTTTTTTTITTVHVHPVYYHHSTSYFLQMEPYPDPPPSDSTAVMPWHSESLGDLTHSDSESSLHMSDRQRLAPKPPQMIRAADEALSAMTSNGSHRLIEGAHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSSPALPSGSPHLDSSRSHSPSPPDPDTPSPAGDSRALQASRNTRIPHLAGKKAAAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK", "length": 789, "header": "tr|A0AAA9SQQ0-1|A0AAA9SQQ0_BOVIN Isoform 1 of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=1 CANONICAL=A0AAA9SQQ0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#A0A3Q1M3V5-1", "sequence": { "sequence": "MDVCARLALWLLWGLLLHHGQSLSQSHSEKATGSGANSEESTAAELGISLDCSPCLYPDCLLSPLEEFCRIDKPLCHSEDEKLSFDAVRSIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRLAPKPPQMIRAADEALSAMTSNGSHRLIEGAHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSSPALPSGSPHLDSSRSHSPSPPDPDTPSPAGDSRALQASRNTRIPHLAGKKAAAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK", "length": 705, "header": "tr|A0A3Q1M3V5-1|A0A3Q1M3V5_BOVIN Computationally mapped isoform of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=2 CANONICAL=A0AAA9SQQ0-1" }, "locus": { "chromosome": "15", "start_pos": 51216371, "end_pos": 51013823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071503.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071503.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062892.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062892.2" } ] } }, { "isoform_ac": "A0A3Q1MFU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#A0A3Q1MFU0-1", "sequence": { "sequence": "MCALVLPCGSFGGSSCITARASAKATARRRPAPAPILRSPLQQFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRLAPKPPQMIRAADEALSAMTSNGSHRLIEGAHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSSPALPSGSPHLDSSRSHSPSPPDPDTPSPAGDSRALQASRNTRIPHLAGKKAAAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK", "length": 638, "header": "tr|A0A3Q1MFU0-1|A0A3Q1MFU0_BOVIN Computationally mapped isoform of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=2 CANONICAL=A0AAA9SQQ0-1" }, "locus": { "chromosome": "15", "start_pos": 51216367, "end_pos": 51013823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068376.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068376.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073088.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073088.2" } ] } }, { "isoform_ac": "A0AAA9SQQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#A0AAA9SQQ0-1", "sequence": { "sequence": "MDVCARLALWLLWGLLLHHGQSLSQSHSEKATGSGANSEESTAAEFCRIDKPLCHSEDEKLSFDAVRSIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRLVEGEAGHFLTSRVSLRRMRSLSSGQSFSSEGLGTSAPPASASSSCSSATTTTTTTTTTTTTITTVHVHPVYYHHSTSYFLQMEPYPDPPPSDSTAVMPWHSESLGDLTHSDSESSLHMSDRQRLAPKPPQMIRAADEALSAMTSNGSHRLIEGAHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSSPALPSGSPHLDSSRSHSPSPPDPDTPSPAGDSRALQASRNTRIPHLAGKKAAAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK", "length": 789, "header": "tr|A0AAA9SQQ0-1|A0AAA9SQQ0_BOVIN Isoform 1 of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=1 CANONICAL=A0AAA9SQQ0-1" }, "locus": { "chromosome": "15", "start_pos": 51216371, "end_pos": 51013823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120629.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120629.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086277.1" } ] } }, { "isoform_ac": "A0AAA9T0U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#A0AAA9T0U2-1", "sequence": { "sequence": "MDVCARLALWLLWGLLLHHGQSLSQSHSEKATGSGANSEESTAAEFCRIDKPLCHSEDEKLSFDAVRSIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRGSSLKANRLSSKGFDPFRFGVLPPHE", "length": 538, "header": "tr|A0AAA9T0U2-1|A0AAA9T0U2_BOVIN Computationally mapped isoform of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=1 CANONICAL=A0AAA9SQQ0-1" }, "locus": { "chromosome": "15", "start_pos": 51216371, "end_pos": 51014295, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090003.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090003.1" } ] } }, { "isoform_ac": "A0AAA9T986-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#A0AAA9T986-1", "sequence": { "sequence": "MDVCARLALWLLWGLLLHHGQSLSQSHSEKATGSGANSEESTAAEFCRIDKPLCHSEDEKLSFDAVRSIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQYAAWLMGRRFSDRSLCSASAGSDDQSLWKYPAPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRLAPKPPQMIRAADEALSAMTSNGSHRLIEGAHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSSPALPSGSPHLDSSRSHSPSPPDPDTPSPAGDSRALQASRNTRIPHLAGKKAAAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK", "length": 714, "header": "tr|A0AAA9T986-1|A0AAA9T986_BOVIN Computationally mapped isoform of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=1 CANONICAL=A0AAA9SQQ0-1" }, "locus": { "chromosome": "15", "start_pos": 51216371, "end_pos": 51013823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135541.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135541.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094561.1" } ] } }, { "isoform_ac": "G3X721-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0/entry#G3X721-1", "sequence": { "sequence": "MDVCARLALWLLWGLLLHHGQSLSQSHSEKATGSGANSEESTAAEFCRIDKPLCHSEDEKLSFDAVRSIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGLRASSLQAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPTHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRLAPKPPQMIRAADEALSAMTSNGSHRLIEGAHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSSPALPSGSPHLDSSRSHSPSPPDPDTPSPAGDSRALQASRNTRIPHLAGKKAAAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK", "length": 690, "header": "tr|G3X721-1|G3X721_BOVIN Computationally mapped isoform of Stromal interaction molecule 1 OS=Bos taurus OX=9913 GN=STIM1 PE=4 SV=2 CANONICAL=A0AAA9SQQ0-1" }, "locus": { "chromosome": "15", "start_pos": 51216371, "end_pos": 51013823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017425.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017425.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017425.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017425.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5578775", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5578775", "resource": "Reactome", "description": "Ion homeostasis" }, { "id": "R-BTA-983695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983695", "resource": "Reactome", "description": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "calcium channel regulator activity", "id": "GO:0005246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "regulation of transport", "id": "GO:0051049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051049", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" }, { "name": "store-operated calcium entry", "id": "GO:0002115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002115", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" }, { "start_pos": 762, "end_pos": 764, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQQ0" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 188, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 169, "end_pos": 171 }, { "start_pos": 658, "end_pos": 660 }, { "start_pos": 762, "end_pos": 764 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQR2-1", "uniprot_ac": "A0AAA9SQR2", "uniprot_id": "A0AAA9SQR2_BOVIN", "mass": { "chemical_mass": 9325.0, "monoisotopic_mass": 9325.0 }, "refseq": {}, "gene_names": [ { "name": "SELENOW", "type": "recommended", "evidence": [ { "id": "A0AAA9SQR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2" } ] } ], "protein_names": [ { "name": "Selenoprotein W", "type": "recommended", "evidence": [ { "id": "A0AAA9SQR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2#function" }, { "database": "UniProtKB", "id": "ARBA00037546", "url": "https://www.uniprot.org/uniprotkb/ARBA00037546#function" }, { "database": "UniProtKB", "id": "A0ABI0NXZ2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXZ2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SELENOW", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SQR2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQR2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15124:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15124:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10262", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10262", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXZ2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVVVRVVYCGAGYKPKYLQLKKKLEDEFPSRLDICGEGTPQVTGFFEVFVAGKLVHSKKGGDGYVDTESKFLKLVAAIKAALAQA", "length": 86, "header": "tr|A0AAA9SQR2-1|A0AAA9SQR2_BOVIN Isoform 1 of Selenoprotein W OS=Bos taurus OX=9913 GN=SELENOW PE=3 SV=2 CANONICAL=A0AAA9SQR2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2/entry#A0AAA9SQR2-1", "sequence": { "sequence": "MAVVVRVVYCGAGYKPKYLQLKKKLEDEFPSRLDICGEGTPQVTGFFEVFVAGKLVHSKKGGDGYVDTESKFLKLVAAIKAALAQA", "length": 86, "header": "tr|A0AAA9SQR2-1|A0AAA9SQR2_BOVIN Isoform 1 of Selenoprotein W OS=Bos taurus OX=9913 GN=SELENOW PE=3 SV=2 CANONICAL=A0AAA9SQR2-1" }, "locus": { "chromosome": "18", "start_pos": 54674321, "end_pos": 54671913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089648.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089648.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086372.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086372.2" } ] } }, { "isoform_ac": "A0ABI0NXZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2/entry#A0ABI0NXZ2-1", "sequence": { "sequence": "MAVVVRVVYWARGPEYLQLKKKLEDEFPSRLDICGEGTPQVTGFFEVFVAGKLVHSKKGGDGYVDTESKFLKLVAAIKAALAQA", "length": 84, "header": "tr|A0ABI0NXZ2-1|A0ABI0NXZ2_BOVIN Computationally mapped isoform of Selenoprotein W OS=Bos taurus OX=9913 GN=SELENOW PE=3 SV=1 CANONICAL=A0AAA9SQR2-1" }, "locus": { "chromosome": "18", "start_pos": 54674321, "end_pos": 54671913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150359.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150359.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106905.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "antioxidant activity", "id": "GO:0016209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQR3-1", "uniprot_ac": "A0AAA9SQR3", "uniprot_id": "A0AAA9SQR3_BOVIN", "mass": { "chemical_mass": 29672.0, "monoisotopic_mass": 29672.0 }, "refseq": {}, "gene_names": [ { "name": "FAM3A", "type": "recommended", "evidence": [ { "id": "A0AAA9SQR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ] } ], "protein_names": [ { "name": "FAM3 metabolism regulating signaling molecule A", "type": "synonym", "evidence": [ { "id": "A0AAA9SQR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM3A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3", "locus": { "chromosome": "X", "start_pos": 37555427, "end_pos": 37569599, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012747", "url": "https://www.ensembl.org/id/ENSBTAG00000012747" } ] } } ], "crossref": [ { "id": "A0AAA9SQR3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd13940", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13940", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR039220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15711", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15711", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QW16", "url": "https://www.uniprot.org/uniprotkb/F6QW16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QW16-1", "url": "https://www.uniprot.org/uniprotkb/F6QW16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLISTNQIISAHASLLNKGTRGQSAGSPKAAPAGCPSPTREVDMRLAGPLRIMALVITVAVTWIVVSILLSGLGFPWIQQLFASQENSVTAEPRARKYKCGLPQPCPEEHLAFRVVSGAANVIGPKICLEDRMLMSSVKDNVGRGLNIALVNGVNGDLIEARAFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKLFSDLGSKNVKDLAFRDSWVFVGAKGVQNKSPFEQHMKNSKHTNKYEGWPEALEMEGCIPRRPAAS", "length": 272, "header": "tr|A0AAA9SQR3-1|A0AAA9SQR3_BOVIN Isoform 1 of FAM3 metabolism regulating signaling molecule A OS=Bos taurus OX=9913 GN=FAM3A PE=3 SV=1 CANONICAL=A0AAA9SQR3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3/entry#A0AAA9SQR3-1", "sequence": { "sequence": "MTLISTNQIISAHASLLNKGTRGQSAGSPKAAPAGCPSPTREVDMRLAGPLRIMALVITVAVTWIVVSILLSGLGFPWIQQLFASQENSVTAEPRARKYKCGLPQPCPEEHLAFRVVSGAANVIGPKICLEDRMLMSSVKDNVGRGLNIALVNGVNGDLIEARAFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKLFSDLGSKNVKDLAFRDSWVFVGAKGVQNKSPFEQHMKNSKHTNKYEGWPEALEMEGCIPRRPAAS", "length": 272, "header": "tr|A0AAA9SQR3-1|A0AAA9SQR3_BOVIN Isoform 1 of FAM3 metabolism regulating signaling molecule A OS=Bos taurus OX=9913 GN=FAM3A PE=3 SV=1 CANONICAL=A0AAA9SQR3-1" }, "locus": { "chromosome": "X", "start_pos": 37569568, "end_pos": 37555965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129818.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129818.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085292.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085292.1" } ] } }, { "isoform_ac": "F6QW16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3/entry#F6QW16-1", "sequence": { "sequence": "MRLAGPLRIMALVITVAVTWIVVSILLSGLGFPWIQQLFASQENSVTAEPRARKYKCGLPQPCPEEHLAFRVVSGAANVIGPKICLEDRMLMSSVKDNVGRGLNIALVNDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKLFSDLGSKNVKDLAFRDSWVFVGAKGVQNKSPFEQHMKNSKHTNKYEGWPEALEMEGCIPRRPAAS", "length": 211, "header": "tr|F6QW16-1|F6QW16_BOVIN Computationally mapped isoform of FAM3 metabolism regulating signaling molecule A OS=Bos taurus OX=9913 GN=FAM3A PE=3 SV=1 CANONICAL=A0AAA9SQR3-1" }, "locus": { "chromosome": "X", "start_pos": 37563280, "end_pos": 37555965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046883.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046883.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044129.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044129.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of antifungal innate immune response", "id": "GO:1905035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905035", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ], "pmid": "" }, { "name": "antifungal humoral response", "id": "GO:0019732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019732", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ], "pmid": "" }, { "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "id": "GO:0061844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQR3" }, { "id": "PF15711", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15711" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ILEI/PANDER", "eco_id": "ECO_0000259", "start_pos": 145, "end_pos": 232, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQU6-1", "uniprot_ac": "A0AAA9SQU6", "uniprot_id": "A0AAA9SQU6_BOVIN", "mass": { "chemical_mass": 35725.0, "monoisotopic_mass": 35725.0 }, "refseq": { "ac": "NP_001377475", "name": "olfactory receptor family 6 subfamily C member 1S", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377475" }, "gene_names": [ { "name": "OR6C1S", "type": "recommended", "evidence": [ { "id": "A0AAA9SQU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6" } ] }, { "name": "OR6C1S", "type": "synonym", "evidence": [ { "id": "NP_001377475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377475" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SQU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 6 subfamily C member 1S", "type": "synonym", "evidence": [ { "id": "NP_001377475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377475" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377475" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C1S", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6", "locus": { "chromosome": "5", "start_pos": 58917462, "end_pos": 58916524, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061225", "url": "https://www.ensembl.org/id/ENSBTAG00000061225" } ] } } ], "crossref": [ { "id": "A0AAA9SQU6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788160", "url": "https://www.ncbi.nlm.nih.gov/gene/788160", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788160", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788160", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNYTEITEFILLGLSDDPQLQVVSFIFLLITYMLSITGNLTIITLTLLDAHLQTPMYFFLRNFSLLEISFTTVSIPKFLATIITGDKTIPFNDCMAQLFFLIFLGVTEFYLLAAMSYDRYFAICKPLHYLTIMNHKVCTLLVLASWLTSFLIIFPLVMLFLQLDYCKSNVIDHFSCDYFPLLYLSCSDTKFLEIVGFSWAVFILLFTLALIILSYTYIIRTILRIPSTNQRTKAFSTCSSHMIAISISYGSCIIMYMNPSAKDRVSSSKGVAVLNTSIAPMLNPFIYTLRNQQVKRAFMDTARKTVFFSSK", "length": 312, "header": "tr|A0AAA9SQU6-1|A0AAA9SQU6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C1S PE=3 SV=1 CANONICAL=A0AAA9SQU6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6/entry#A0AAA9SQU6-1", "sequence": { "sequence": "MRNYTEITEFILLGLSDDPQLQVVSFIFLLITYMLSITGNLTIITLTLLDAHLQTPMYFFLRNFSLLEISFTTVSIPKFLATIITGDKTIPFNDCMAQLFFLIFLGVTEFYLLAAMSYDRYFAICKPLHYLTIMNHKVCTLLVLASWLTSFLIIFPLVMLFLQLDYCKSNVIDHFSCDYFPLLYLSCSDTKFLEIVGFSWAVFILLFTLALIILSYTYIIRTILRIPSTNQRTKAFSTCSSHMIAISISYGSCIIMYMNPSAKDRVSSSKGVAVLNTSIAPMLNPFIYTLRNQQVKRAFMDTARKTVFFSSK", "length": 312, "header": "tr|A0AAA9SQU6-1|A0AAA9SQU6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C1S PE=3 SV=1 CANONICAL=A0AAA9SQU6-1" }, "locus": { "chromosome": "5", "start_pos": 58917459, "end_pos": 58916524, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129057.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129057.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086333.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788160", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788160", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 276, "end_pos": 278 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQW3-1", "uniprot_ac": "A0AAA9SQW3", "uniprot_id": "A0AAA9SQW3_BOVIN", "mass": { "chemical_mass": 11122.0, "monoisotopic_mass": 11122.0 }, "refseq": { "ac": "NP_001161296", "name": "cystatin-A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161296" }, "gene_names": [ { "name": "CSTA", "type": "recommended", "evidence": [ { "id": "A0AAA9SQW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ] }, { "name": "CSTA", "type": "synonym", "evidence": [ { "id": "NP_001161296", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161296" } ] } ], "protein_names": [ { "name": "Cystatin A", "type": "synonym", "evidence": [ { "id": "A0AAA9SQW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3/entry#names_and_taxonomy" } ] }, { "name": "cystatin AS", "type": "synonym", "evidence": [ { "id": "NP_001161296", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161296" } ] }, { "name": "cystatin-A", "type": "synonym", "evidence": [ { "id": "NP_001161296", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161296" } ] }, { "name": "stefin A", "type": "synonym", "evidence": [ { "id": "NP_001161296", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161296" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSTA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3", "locus": { "chromosome": "1", "start_pos": 66800939, "end_pos": 66773102, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062313", "url": "https://www.ensembl.org/id/ENSBTAG00000062313" } ] } } ], "crossref": [ { "id": "A0AAA9SQW3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617114", "url": "https://www.ncbi.nlm.nih.gov/gene/617114", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617114", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617114", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11414:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11414:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001161296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161296", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIPGGLTEAKPATPEIQEIANMVKPQLEEKTNETYEEFTAIEYKTQVVAGINYYIKIQTGDNRYIHIKVFKSLPQQSHSLILTGYQVDKTKDDELAGF", "length": 98, "header": "tr|A0AAA9SQW3-1|A0AAA9SQW3_BOVIN Isoform 1 of Cystatin A OS=Bos taurus OX=9913 GN=CSTA PE=3 SV=2 CANONICAL=A0AAA9SQW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3/entry#A0AAA9SQW3-1", "sequence": { "sequence": "MIPGGLTEAKPATPEIQEIANMVKPQLEEKTNETYEEFTAIEYKTQVVAGINYYIKIQTGDNRYIHIKVFKSLPQQSHSLILTGYQVDKTKDDELAGF", "length": 98, "header": "tr|A0AAA9SQW3-1|A0AAA9SQW3_BOVIN Isoform 1 of Cystatin A OS=Bos taurus OX=9913 GN=CSTA PE=3 SV=2 CANONICAL=A0AAA9SQW3-1" }, "locus": { "chromosome": "1", "start_pos": 66783655, "end_pos": 66773125, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102243.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102243.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087741.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087741.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617114", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617114", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" }, { "name": "cornified envelope", "id": "GO:0001533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001533", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "keratinocyte differentiation", "id": "GO:0030216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030216", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" }, { "name": "negative regulation of proteolysis", "id": "GO:0045861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQW3" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 98, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQX6-1", "uniprot_ac": "A0AAA9SQX6", "uniprot_id": "A0AAA9SQX6_BOVIN", "mass": { "chemical_mass": 57405.0, "monoisotopic_mass": 57405.0 }, "refseq": { "ac": "XP_010811977", "name": "tigger transposable element-derived protein 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811977" }, "gene_names": [ { "name": "TIGD4", "type": "recommended", "evidence": [ { "id": "A0AAA9SQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" } ] }, { "name": "TIGD4", "type": "synonym", "evidence": [ { "id": "XP_010811977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811977" } ] } ], "protein_names": [ { "name": "Tigger transposable element derived 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6/entry#names_and_taxonomy" } ] }, { "name": "tigger transposable element-derived protein 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010811977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811977" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIGD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6", "locus": { "chromosome": "17", "start_pos": 4899867, "end_pos": 4887157, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068286", "url": "https://www.ensembl.org/id/ENSBTAG00000068286" } ] } } ], "crossref": [ { "id": "101907287", "url": "https://www.ncbi.nlm.nih.gov/gene/101907287", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101907287", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907287", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR19303", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19303", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19303:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19303:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03184", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03184", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03221", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03221", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04218", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04218", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010811977", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAPVDASTLPVTVKKKKSLSIEEKIDIINAVESGKKKAEIAAEYGIKKNSLSSIMKNKDKVLEAFESLRFDPKRKRLRTAFYTDLEEALMRWYRIAQCLNVPVNGPMLRLKANDFAQKLGHNDFKCSNGWLDRFKSRYGLVFRAQPVEATGVSADPSAVWHQNILPYYLNDYHPKNVFNVKETGLLYRMLPTNTFAFKGETCSIGKLCKDRITLVVGTNMDGSEKLPLLLIGKNRNPRCFKGIQSLPVCYEANKMAWMTAEVFEQWMQKLDERFQAQQRRVVIFVESSPAHPEVKNLKSIELAFFPSCLSSKFIAMKQGVIRSLKIKYRHCLIKKFLSSVEGSKEFTFSLLDAVDTLHLCWRAVTPETIVKSYEEAGFKSQRGESEEASAETDTGLDLVADAQAAGVEFPEGLSVEEYAALDDDLETCEAAPSGDAVCPKESESDETGFYTSDEEEDGGSLESELPLPSKNEAITALDTLKTFLRSQDINDELHNALADLEIFINSLSSK", "length": 512, "header": "tr|A0AAA9SQX6-1|A0AAA9SQX6_BOVIN Isoform 1 of Tigger transposable element derived 4 OS=Bos taurus OX=9913 GN=TIGD4 PE=4 SV=1 CANONICAL=A0AAA9SQX6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6/entry#A0AAA9SQX6-1", "sequence": { "sequence": "MAEAPVDASTLPVTVKKKKSLSIEEKIDIINAVESGKKKAEIAAEYGIKKNSLSSIMKNKDKVLEAFESLRFDPKRKRLRTAFYTDLEEALMRWYRIAQCLNVPVNGPMLRLKANDFAQKLGHNDFKCSNGWLDRFKSRYGLVFRAQPVEATGVSADPSAVWHQNILPYYLNDYHPKNVFNVKETGLLYRMLPTNTFAFKGETCSIGKLCKDRITLVVGTNMDGSEKLPLLLIGKNRNPRCFKGIQSLPVCYEANKMAWMTAEVFEQWMQKLDERFQAQQRRVVIFVESSPAHPEVKNLKSIELAFFPSCLSSKFIAMKQGVIRSLKIKYRHCLIKKFLSSVEGSKEFTFSLLDAVDTLHLCWRAVTPETIVKSYEEAGFKSQRGESEEASAETDTGLDLVADAQAAGVEFPEGLSVEEYAALDDDLETCEAAPSGDAVCPKESESDETGFYTSDEEEDGGSLESELPLPSKNEAITALDTLKTFLRSQDINDELHNALADLEIFINSLSSK", "length": 512, "header": "tr|A0AAA9SQX6-1|A0AAA9SQX6_BOVIN Isoform 1 of Tigger transposable element derived 4 OS=Bos taurus OX=9913 GN=TIGD4 PE=4 SV=1 CANONICAL=A0AAA9SQX6-1" }, "locus": { "chromosome": "17", "start_pos": 4899149, "end_pos": 4897614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115982.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115982.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085363.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101907287", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907287", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" }, { "id": "PRU00320", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00320" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "H-T-H motif", "eco_id": "ECO_0000256", "start_pos": 39, "end_pos": 59, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" }, { "id": "PS51253", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51253" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HTH CENPB-type", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 146, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX6" }, { "id": "PS50960", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50960" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HTH psq-type", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 63, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQX8-1", "uniprot_ac": "A0AAA9SQX8", "uniprot_id": "A0AAA9SQX8_BOVIN", "mass": { "chemical_mass": 46572.0, "monoisotopic_mass": 46572.0 }, "refseq": {}, "gene_names": [ { "name": "LOC530653", "type": "recommended", "evidence": [ { "id": "A0AAA9SQX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ] } ], "protein_names": [ { "name": "Bile acid-CoA:amino acid N-acyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SQX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC530653", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SQX8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025760", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025760", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RPFLWGG", "url": "https://omabrowser.org/oma/group/RPFLWGG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MS29", "url": "https://www.orthodb.org/?gene=A0A3Q1MS29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MBX4", "url": "https://www.orthodb.org/?gene=F1MBX4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10824", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10824", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10824:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10824:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MS29", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T730", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T730", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T730-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T730-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBX4", "url": "https://www.uniprot.org/uniprotkb/F1MBX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBX4-1", "url": "https://www.uniprot.org/uniprotkb/F1MBX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFQLTVTPASALADEPVHIQATGLPPLQMVTLIATMKDDKGNLYRSRAFYRANEAGELDLKRDPAVGGHYMGVHPMGLLWSLKPERPFDRLIKRNVMNTPTWITLDLYDSVYIHKVGEAQPKASQVLQRWFSSPDLQRVPIREGRIRGALFLPPGEGPFPGLLDLFGGIGGLVEYRASLLAVRGFAVLALAYFAYDDLPKQLEEVDLEYFEEAANLLLAHPKVQKPGIGVISVSKGAEIGLAMACYLKQVAATVCINGANAIHEFPLRYRDLVITPIPSFPERMQVNAAGAVRIRHFKGDPRDERNQHSVLPVEKARGPILFVVGEADECFNSKEYAEQALDQLRRHGKSSGRMLSYPGAGHLIEPPYAPLCCVSWSRGLFLPMLWGGEPEGQAAAQEHSWQEILKFFRQHLVLSRSTL", "length": 419, "header": "tr|A0AAA9SQX8-1|A0AAA9SQX8_BOVIN Isoform 1 of Bile acid-CoA:amino acid N-acyltransferase OS=Bos taurus OX=9913 GN=LOC530653 PE=3 SV=1 CANONICAL=A0AAA9SQX8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MS29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8/entry#A0A3Q1MS29-1", "sequence": { "sequence": "MMHIYVKVSGNTIWSLCLLPMFQLTVTPASALADEPVHIQATGLPPLQMVTLIATMKDDKGNLYRSRAFYRANEAGELDLKRDPAVGGHYMGVHPMGLLWSLKPERPFDRLIKRNVMNTPTWITLDLYDSVYIHKVGEAQPKASQVLQRWFSSPDLQRVPIREGRIRGALFLPPGEGPFPGLLDLFGGIGGLVEYRASLLAVRGFAVLALAYFAYDDLPKQLEEVDLEYFEEAANLLLAHPKVQKPGIGVISVSKGAEIGLAMACYLKQVAATVCINGANAIHEFPLRYRDLVITPIPSFPERMQVNAAGAVRIRHFKGDPRDERNQHSVLPVEKARGPILFVVGEADECFNSKEYAEQALDQLRRHGKSSGRMLSYPGAGHLIEPPYAPLCCVSWSRGLFLPMLWGGEPEGQAAAQEHSWQEILKFFRQHLVLSRSTL", "length": 439, "header": "tr|A0A3Q1MS29-1|A0A3Q1MS29_BOVIN Computationally mapped isoform of Bile acid-CoA:amino acid N-acyltransferase OS=Bos taurus OX=9913 GN=LOC530653 PE=3 SV=2 CANONICAL=A0AAA9SQX8-1" }, "locus": { "chromosome": "8", "start_pos": 91061551, "end_pos": 91056976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079956.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079956.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057226.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057226.2" } ] } }, { "isoform_ac": "A0AAA9SQX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8/entry#A0AAA9SQX8-1", "sequence": { "sequence": "MFQLTVTPASALADEPVHIQATGLPPLQMVTLIATMKDDKGNLYRSRAFYRANEAGELDLKRDPAVGGHYMGVHPMGLLWSLKPERPFDRLIKRNVMNTPTWITLDLYDSVYIHKVGEAQPKASQVLQRWFSSPDLQRVPIREGRIRGALFLPPGEGPFPGLLDLFGGIGGLVEYRASLLAVRGFAVLALAYFAYDDLPKQLEEVDLEYFEEAANLLLAHPKVQKPGIGVISVSKGAEIGLAMACYLKQVAATVCINGANAIHEFPLRYRDLVITPIPSFPERMQVNAAGAVRIRHFKGDPRDERNQHSVLPVEKARGPILFVVGEADECFNSKEYAEQALDQLRRHGKSSGRMLSYPGAGHLIEPPYAPLCCVSWSRGLFLPMLWGGEPEGQAAAQEHSWQEILKFFRQHLVLSRSTL", "length": 419, "header": "tr|A0AAA9SQX8-1|A0AAA9SQX8_BOVIN Isoform 1 of Bile acid-CoA:amino acid N-acyltransferase OS=Bos taurus OX=9913 GN=LOC530653 PE=3 SV=1 CANONICAL=A0AAA9SQX8-1" }, "locus": { "chromosome": "8", "start_pos": 91060506, "end_pos": 91056976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121653.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121653.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086368.1" } ] } }, { "isoform_ac": "A0AAA9T730-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8/entry#A0AAA9T730-1", "sequence": { "sequence": "MFQLTVTPASALADEPVHIQATGLPPLQMVTLIATMKDDKGNLYRSRAFYRANEAGELDLKRDPAVGGHYMGVHPMGLLWSLKPERPFDRLIKRNVMNTPTWITLDLYDSVYIHKVGEAQPKASQVLQRWFSSPDLQRVPIREGRIRGALFLPPGEGPFPGLLDLFGGIGGLVEYRASLLAVRGFAVLALAYFAYDDLPKQLEEVDLEYFEEAANLLLAHPKVQKPGIGVISVSKGAEIGLAMACYLKQVAATVCINGANAIHEFPLRYRDLVITPIPSFPERMQVNAAGAVRIRHFKGDPRDERNQHSVLPVEKARGPILFVVGEADECFNSKEYAEQALDQLRRHGKSSGRMLSYPGAGHLIEPPYAPLCCVSWSRGLFLPMLWGGEPEGQAAAQEHSWQEILKFFRQHLVLSRSTLDSCRHRMWHNSGQ", "length": 432, "header": "tr|A0AAA9T730-1|A0AAA9T730_BOVIN Computationally mapped isoform of Bile acid-CoA:amino acid N-acyltransferase OS=Bos taurus OX=9913 GN=LOC530653 PE=3 SV=1 CANONICAL=A0AAA9SQX8-1" }, "locus": { "chromosome": "8", "start_pos": 91060506, "end_pos": 91053324, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088934.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088934.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091617.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091617.1" } ] } }, { "isoform_ac": "F1MBX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8/entry#F1MBX4-1", "sequence": { "sequence": "MRIMSTLCTPYFSLLQMFRVFCSNLQKSSGPVQALSEPLPWNQSLQLRVFSPTAGNTIWSLCLLPMFQLTVTPASALADEPVHIQATGLPPLQMVTLIATMKDDKGNLYRSRAFYRANEAGELDLKRDPAVGGHYMGVHPMGLLWSLKPERPFDRLIKRNVMNTPTWITLDLYDSVYIHKVGEAQPKASQVLQRWFSSPDLQRVPIREGRIRGALFLPPGEGPFPGLLDLFGGIGGLVEYRASLLAVRGFAVLALAYFAYDDLPKQLEEVDLEYFEEAANLLLAHPKVQKPGIGVISVSKGAEIGLAMACYLKQVAATVCINGANAIHEFPLRYRDLVITPIPSFPERMQVNAAGAVRIRHFKGDPRDERNQHSVLPVEKARGPILFVVGEADECFNSKEYAEQALDQLRRHGKSSGRMLSYPGAGHLIEPPYAPLCCVSWSRGLFLPMLWGGEPEGQAAAQEHSWQEILKFFRQHLVLSRSTL", "length": 484, "header": "tr|F1MBX4-1|F1MBX4_BOVIN Computationally mapped isoform of Bile acid-CoA:amino acid N-acyltransferase OS=Bos taurus OX=9913 GN=LOC530653 PE=3 SV=2 CANONICAL=A0AAA9SQX8-1" }, "locus": { "chromosome": "8", "start_pos": 91060701, "end_pos": 91056976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036413.4", "url": "https://www.ensembl.org/id/ENSBTAT00000036413.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036271.3", "url": "https://www.ensembl.org/id/ENSBTAP00000036271.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287B8D4-1", "protein_name": "Bile acid-CoA:amino acid N-acyltransferase", "gene_name": "LOC100515185", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFQLTATPASALADEPVHIRVMGLAPLQVVTLMASLKDEKGNLFQSRAFYRANEAGELDLEQDPALGGDFVGVHPMGLFWSLKPEKPFGGLLKLEVMNSPFWITLDLYDSVYLQKSGVVQPRASLELQRWFSSPGVQRLMIREGRVRGALFLPPGEGPFPGIIDLFGGIGGLLEYRAGLLAAHGFAALALAYFAYDDLPNQLQEVDLDYFEEAANLLLAHPKIQKPGIGVISVSKGAEIGLAMACYLKQVVATVCINGSNAIFEVPLRYRDLVLTPIPSFLERMEVNASGAVRLRHCMGDPRDELNQQSVLPIEKSQGQILFIIGEDDECLNSRDYAEQALGQLQSHGRSNGRMLLYPGAGHLIEPPYGPLCYGSRTRGFPLPLLWGGDPVAHAAAQEHAWREILKFFRQHLVGSRSKL", "length": 419 }, "evidence": [ { "id": "A0AAA9SQX8", "url": "https://omabrowser.org/oma/group/A0AAA9SQX8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A2AKK5-1", "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 1", "gene_name": "Acnat1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMIKLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQAFYKTNEAGEVDLEKTPALGGDYVGVHPMGLFFSLKPKKAFHRLMKKDVMNSPFCICLDLYDSVNWLETVRIPSKASQRVQRWFVGPGVKREQIQEGRVRGALFLPPGKGPFPGIIDLFGVIGGLVEFRASLLASHGFAVLALAYFAYKDLPEKLQEVDLEYFEEAANFLLSHPKIQQPGIGVISTSKGAEIGLAMACYLKQVIATVCINGATTTTAVPLRYQDLVVTPIQQALERMEVHVSGAVCFRHTTQYLQNKNILPVEKAQGKILFIVGENDELLDSKLHAQRAMDRLRRHGRSSGRMLAYPGAGHLIEPPYSPLCFASWQPVLGRPMCFGGDLMAHAAAQEHSWREIQKFFRKHLLQSGSKL", "length": 416 }, "evidence": [ { "id": "A0AAA9SQX8", "url": "https://omabrowser.org/oma/group/A0AAA9SQX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ], "pmid": "" }, { "name": "acyl-CoA metabolic process", "id": "GO:0006637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006637", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thiolester hydrolase activity", "id": "GO:0016790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016790", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ], "pmid": "" }, { "name": "fatty acyl-CoA hydrolase activity", "id": "GO:0047617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047617", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" }, { "id": "PF04775", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04775" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 143, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX8" }, { "id": "PF08840", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08840" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAAT/Acyl-CoA thioester hydrolase C-terminal", "eco_id": "ECO_0000259", "start_pos": 205, "end_pos": 412, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQY1-1", "uniprot_ac": "A0AAA9SQY1", "uniprot_id": "A0AAA9SQY1_BOVIN", "mass": { "chemical_mass": 96338.0, "monoisotopic_mass": 96338.0 }, "refseq": {}, "gene_names": [ { "name": "MIPEP", "type": "recommended", "evidence": [ { "id": "A0AAA9SQY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ] } ], "protein_names": [ { "name": "Mitochondrial intermediate peptidase", "type": "recommended", "evidence": [ { "id": "A0AAA9SQY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1/entry#names_and_taxonomy" } ] }, { "name": "3.4.24.59", "type": "synonym", "evidence": [ { "id": "A0AAA9SQY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cleaves proteins, imported into the mitochondrion, to their mature size.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1#function" }, { "database": "UniProtKB", "id": "ARBA00059424", "url": "https://www.uniprot.org/uniprotkb/ARBA00059424#function" }, { "database": "UniProtKB", "id": "F1MX73", "url": "https://www.uniprot.org/uniprotkb/F1MX73#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MIPEP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1", "locus": { "chromosome": "12", "start_pos": 34390724, "end_pos": 34304705, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008888", "url": "https://www.ensembl.org/id/ENSBTAG00000008888" } ] } } ], "crossref": [ { "id": "A0AAA9SQY1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008888", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008888", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06457", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06457", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517531", "url": "https://www.ncbi.nlm.nih.gov/gene/517531", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517531", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517531", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MX73", "url": "https://www.orthodb.org/?gene=F1MX73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11804", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11804", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11804:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11804:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX73", "url": "https://www.uniprot.org/uniprotkb/F1MX73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX73-1", "url": "https://www.uniprot.org/uniprotkb/F1MX73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAPRGHREGPFRPQPSPSLPLPSRPRSPSVGLSSISVSSRSVDRGQPTALAARLARGVQRSFLERRPTGGDGSRSSVRARAVPAPLAGSRPSPGLVAGRRVLRCPLPARGGAPRGGRRRATLWPRGPSPPGSARSRGARALPRKRGEMLCARRLGGLRAGLRVRRVSTGWSPVGAAFTVQPQGRRLDWFGERGGLFGVPELSAPEGFRVAQEKALRRTEQLVQRVCATPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEAAFREAAEEACRSIGTMVEKLNTNVELYQSLQRLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDREKRKRAVDLNVKILDLSSAFLMGTHLPNTIEKRLLPEGIRHHFELAGDHAVVDSLRAEAPDDLVREAAYKIFLYPNAGQLKRLEELLSSRDLLAKLVGYPTYSHRALQGTIAQSPETVMEFLEKLSDKLSERTMKDFEMIRGMKMKLNPQNSADSPPLDHQESPEELMPWDPPYYSGLIRAERFNIEPGLYCPFFSLGACMEGLSLLFNRLLGVSLYGEQPVKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPHSSRNLPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVHQFARHYQTGQSLPRNMVSRLCESKKVCAAADMQLQVFYAALDQIYHGKHPLRSSTTDILRDTQERFYGLPYVPNTAWQLRFSHLVGYGAKYYSYLMSRAVASMVWRECFRQDPFNRAAGERYRREMLAHGGGREPMLMVQGMLQKRPSIDDFVNTLVSDLDLDFETFLMDST", "length": 858, "header": "tr|A0AAA9SQY1-1|A0AAA9SQY1_BOVIN Isoform 1 of Mitochondrial intermediate peptidase OS=Bos taurus OX=9913 GN=MIPEP PE=3 SV=1 CANONICAL=A0AAA9SQY1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1/entry#A0AAA9SQY1-1", "sequence": { "sequence": "MASAPRGHREGPFRPQPSPSLPLPSRPRSPSVGLSSISVSSRSVDRGQPTALAARLARGVQRSFLERRPTGGDGSRSSVRARAVPAPLAGSRPSPGLVAGRRVLRCPLPARGGAPRGGRRRATLWPRGPSPPGSARSRGARALPRKRGEMLCARRLGGLRAGLRVRRVSTGWSPVGAAFTVQPQGRRLDWFGERGGLFGVPELSAPEGFRVAQEKALRRTEQLVQRVCATPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEAAFREAAEEACRSIGTMVEKLNTNVELYQSLQRLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDREKRKRAVDLNVKILDLSSAFLMGTHLPNTIEKRLLPEGIRHHFELAGDHAVVDSLRAEAPDDLVREAAYKIFLYPNAGQLKRLEELLSSRDLLAKLVGYPTYSHRALQGTIAQSPETVMEFLEKLSDKLSERTMKDFEMIRGMKMKLNPQNSADSPPLDHQESPEELMPWDPPYYSGLIRAERFNIEPGLYCPFFSLGACMEGLSLLFNRLLGVSLYGEQPVKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPHSSRNLPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVHQFARHYQTGQSLPRNMVSRLCESKKVCAAADMQLQVFYAALDQIYHGKHPLRSSTTDILRDTQERFYGLPYVPNTAWQLRFSHLVGYGAKYYSYLMSRAVASMVWRECFRQDPFNRAAGERYRREMLAHGGGREPMLMVQGMLQKRPSIDDFVNTLVSDLDLDFETFLMDST", "length": 858, "header": "tr|A0AAA9SQY1-1|A0AAA9SQY1_BOVIN Isoform 1 of Mitochondrial intermediate peptidase OS=Bos taurus OX=9913 GN=MIPEP PE=3 SV=1 CANONICAL=A0AAA9SQY1-1" }, "locus": { "chromosome": "12", "start_pos": 34390558, "end_pos": 34304904, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136014.2", "url": "https://www.ensembl.org/id/ENSBTAT00000136014.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085369.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085369.1" } ] } }, { "isoform_ac": "F1MX73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1/entry#F1MX73-1", "sequence": { "sequence": "MASAPRGHREGPFRPQPSPSLPLPSRPRSPSVGLSSISVSSRSVDRGQPTALAARLARGVQRSFLERRPTGGDGSRSSVRARAVPAPLAGSRPSPGLVAGRRVLRCPLPARGGAPRGGRRRATLWPRGPSPPGSARSRGARALPRKRGEMLCARRLGGLRAGLRVRRVSTGWSPVGAAFTVQPQGRRLDWFGERGGLFGVPELSAPEGFRVAQEKALRRTEQLVQRVCATPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEAAFREAAEEACRSIGTMVEKLNTNVELYQSLQRLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDREKRKRAVDLNVKILDLSSAFLMGTHLPNTIEKRLLPEGIRHHFELAGDHAVVDSLRAEAPDDLVREAAYKIFLYPNAGQLKRLEELLSSRDLLAKLVGYPTYSHRALQGTIAQSPETVMEFLEKLSDKLSERTMKDFEMIRGMKMKLNPQNSELMPWDPPYYSGLIRAERFNIEPGLYCPFFSLGACMEGLSLLFNRLLGVSLYGEQPVKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPHSSRNLPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVHQFARHYQTGQSLPRNMVSRLCESKKVCAAADMQLQVFYAALDQIYHGKHPLRSSTTDILRDTQERFYGLPYVPNTAWQLRFSHLVGYGAKYYSYLMSRAVASMVWRECFRQDPFNRAAGERYRREMLAHGGGREPMLMVQGMLQKRPSIDDFVNTLVSDLDLDFETFLMDST", "length": 845, "header": "tr|F1MX73-1|F1MX73_BOVIN Computationally mapped isoform of Mitochondrial intermediate peptidase OS=Bos taurus OX=9913 GN=MIPEP PE=3 SV=3 CANONICAL=A0AAA9SQY1-1" }, "locus": { "chromosome": "12", "start_pos": 34390558, "end_pos": 34304904, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011704.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011704.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011704.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011704.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:517531", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517531", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "pmid": "" }, { "name": "protein processing involved in protein targeting to mitochondrion", "id": "GO:0006627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006627", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQY1" }, { "id": "PF01432", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01432" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M3A/M3B catalytic", "eco_id": "ECO_0000259", "start_pos": 388, "end_pos": 842, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.24.59", "ec_name": "Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.", "evidence": [ { "id": "3.4.24.59", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.24.59" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQZ4-1", "uniprot_ac": "A0AAA9SQZ4", "uniprot_id": "A0AAA9SQZ4_BOVIN", "mass": { "chemical_mass": 10305.0, "monoisotopic_mass": 10305.0 }, "refseq": { "ac": "XP_059734359", "name": "small integral membrane protein 36", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734359" }, "gene_names": [ { "name": "SMIM36", "type": "recommended", "evidence": [ { "id": "A0AAA9SQZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4" } ] }, { "name": "SMIM36", "type": "synonym", "evidence": [ { "id": "XP_059734359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734359" } ] } ], "protein_names": [ { "name": "Small integral membrane protein 36", "type": "synonym", "evidence": [ { "id": "A0AAA9SQZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4/entry#names_and_taxonomy" } ] }, { "name": "small integral membrane protein 36", "type": "synonym", "evidence": [ { "id": "XP_059734359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734359" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMIM36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4", "locus": { "chromosome": "19", "start_pos": 5715811, "end_pos": 5716092, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059984", "url": "https://www.ensembl.org/id/ENSBTAG00000059984" } ] } } ], "crossref": [ { "id": "A0AAA9SQZ4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "132342983", "url": "https://www.ncbi.nlm.nih.gov/gene/132342983", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:132342983", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132342983", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059734359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734359", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFYLEIDPVTLNLIILVSSYVILLLVFLISCVLYDCRGKDPSKEYAPEASLDAQPSIRLVVMQQGSPGAPWARRSSLHFGNHTPLGKKSTVV", "length": 93, "header": "tr|A0AAA9SQZ4-1|A0AAA9SQZ4_BOVIN Isoform 1 of Small integral membrane protein 36 OS=Bos taurus OX=9913 GN=SMIM36 PE=4 SV=1 CANONICAL=A0AAA9SQZ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ4/entry#A0AAA9SQZ4-1", "sequence": { "sequence": "MEFYLEIDPVTLNLIILVSSYVILLLVFLISCVLYDCRGKDPSKEYAPEASLDAQPSIRLVVMQQGSPGAPWARRSSLHFGNHTPLGKKSTVV", "length": 93, "header": "tr|A0AAA9SQZ4-1|A0AAA9SQZ4_BOVIN Isoform 1 of Small integral membrane protein 36 OS=Bos taurus OX=9913 GN=SMIM36 PE=4 SV=1 CANONICAL=A0AAA9SQZ4-1" }, "locus": { "chromosome": "19", "start_pos": 5716092, "end_pos": 5715814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101242.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101242.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088761.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132342983", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132342983", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR01-1", "uniprot_ac": "A0AAA9SR01", "uniprot_id": "A0AAA9SR01_BOVIN", "mass": { "chemical_mass": 68755.0, "monoisotopic_mass": 68755.0 }, "refseq": { "ac": "XP_015329690", "name": "actin-related protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329690" }, "gene_names": [ { "name": "ACTR5", "type": "recommended", "evidence": [ { "id": "A0AAA9SR01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ] }, { "name": "ACTR5", "type": "synonym", "evidence": [ { "id": "XP_015329690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329690" } ] } ], "protein_names": [ { "name": "Actin-related protein 5", "type": "recommended", "evidence": [ { "id": "A0AAA9SR01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01/entry#names_and_taxonomy" } ] }, { "name": "actin-related protein 5", "type": "synonym", "evidence": [ { "id": "XP_015329690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329690" } ] } ], "function": [ { "annotation": "Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.", "evidence": [ { "database": "UniProtKB", "id": "G3N1W1", "url": "https://www.uniprot.org/uniprotkb/G3N1W1#function" }, { "database": "UniProtKB", "id": "ARBA00054422", "url": "https://www.uniprot.org/uniprotkb/ARBA00054422#function" }, { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01", "locus": { "chromosome": "13", "start_pos": 67566403, "end_pos": 67544872, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048262", "url": "https://www.ensembl.org/id/ENSBTAG00000048262" } ] } } ], "crossref": [ { "id": "A0AAA9SR01", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048262", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048262", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10211", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10211", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100297865", "url": "https://www.ncbi.nlm.nih.gov/gene/100297865", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100297865", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297865", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPFTEHV", "url": "https://omabrowser.org/oma/group/YPFTEHV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N1W1", "url": "https://www.orthodb.org/?gene=G3N1W1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015329690", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1W1", "url": "https://www.uniprot.org/uniprotkb/G3N1W1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1W1-1", "url": "https://www.uniprot.org/uniprotkb/G3N1W1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAATAAGLGTNVFLFRDARAAPDPVLEAGPVAHGSLPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGAGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCTPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNNPKNMISSGLIISSGYQCTHILPILEGRLDARNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELQKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSAAVEQAKQKILQAEVSLEVDVVDSKPETPDLEQLEPSLEDVENINDFEPLFSEETPEVEKPVATVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDVQELLVQNVFLTGGNMMYPGMKVRIEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLDNEDVWITRKDYEEKGGGYLREHCASNVYVPIHLPRQAARSAEAQASGKGSGAGGGGASEQA", "length": 615, "header": "tr|A0AAA9SR01-1|A0AAA9SR01_BOVIN Isoform 1 of Actin-related protein 5 OS=Bos taurus OX=9913 GN=ACTR5 PE=3 SV=1 CANONICAL=A0AAA9SR01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01/entry#A0AAA9SR01-1", "sequence": { "sequence": "MAAATAAGLGTNVFLFRDARAAPDPVLEAGPVAHGSLPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGAGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCTPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNNPKNMISSGLIISSGYQCTHILPILEGRLDARNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELQKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSAAVEQAKQKILQAEVSLEVDVVDSKPETPDLEQLEPSLEDVENINDFEPLFSEETPEVEKPVATVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDVQELLVQNVFLTGGNMMYPGMKVRIEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLDNEDVWITRKDYEEKGGGYLREHCASNVYVPIHLPRQAARSAEAQASGKGSGAGGGGASEQA", "length": 615, "header": "tr|A0AAA9SR01-1|A0AAA9SR01_BOVIN Isoform 1 of Actin-related protein 5 OS=Bos taurus OX=9913 GN=ACTR5 PE=3 SV=1 CANONICAL=A0AAA9SR01-1" }, "locus": { "chromosome": "13", "start_pos": 67564994, "end_pos": 67545071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093568.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093568.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086395.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086395.1" } ] } }, { "isoform_ac": "G3N1W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01/entry#G3N1W1-1", "sequence": { "sequence": "MAAATAAGLGTNVFLFRDARAAPDPVLEAGPVAHGSLPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGAGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCTPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNNPKNMISSGLIISSGYQCTHILPILEGRLDARNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELQKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSAAVEQAKQKILQAEVSLEVDVVDSKPETPDLEQLEPSLEDVENINDFEPLFSEETPEVEKPVATVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDVQELLVQNVFLTGGNMMYPGMKVRIEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLDNEDVWITRKDYEEKGGGYLREHCASNVQHFKQPEEQW", "length": 591, "header": "tr|G3N1W1-1|G3N1W1_BOVIN Computationally mapped isoform of Actin-related protein 5 OS=Bos taurus OX=9913 GN=ACTR5 PE=3 SV=3 CANONICAL=A0AAA9SR01-1" }, "locus": { "chromosome": "13", "start_pos": 67566343, "end_pos": 67545071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065051.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065051.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055865.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055865.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297865", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297865", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5696394", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZW76-1", "protein_name": "Actin-related protein 5", "gene_name": "ACTR5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGRVFAFRDARWAPDPVLAPSAAVRSPQPVPLVIDNGSFQTRAGWAAADPSVPAEPLLRFRSLAARSRGARGGAGAETQVGNDLGSPEPLRWLLRSPFDRNVPVQLELQELLFDHVFQRLGVASQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYQVPKVSYGVDSLYSFYHNRRQNWPCSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGCQAAVYLQRLLQLKYPGHFAAITLSRMEEILHEHSYIAEDYTEELQKWRSPEYYENNVHKMQLPFSNKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALVELNMDSAEELQSYINKLSLAIEQTKQKILQAEVNIEVDVVDSKPETPDLDPLSSEQSLEDVESINEFEPLFAEEQPEAEKPVAAVQPVFNLAEYHQLFLGTERIRAPEIIFQPSLIGEDQTGIAETMQYVLERYSKEQQALLVQNVFLTGGNAMYPGLKARVQKELLEMRPFQSSFQVHLASSPILDAWHGARDWAVEHMTREEGWITRKDYEEKGGEYLKEHCASNVYVPIRLPKQAPRTTEALAPSRALAAGTGNPWSLRSARSGNTTSVRSPGD", "length": 626 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZAQ1-1", "protein_name": "Actin-related protein 5", "gene_name": "Actr5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEANVFRFRDARSAPDPVLEAGPVAFGSQPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGLGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYRIPKVAYGIDSLFSFYHNMPKNALSSGLVISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYAAELQKWRCPDYYENNVHKMQLPFSSKLLGSTLTAEEKQERRQQQLRRLQELNARRREEKLQLDQERLERLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEANLEVDVVDSKPETPDLEPLEPSLEDVENINDFEPLFSEETPEVEKPQVTTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLHYVLDRYPKAVQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYEEKGGEYLKEHCASNTYVPIRLPKQASRASETQTSGRGSGASGSGAGDQA", "length": 609 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53946-1", "protein_name": "Actin-related protein 5", "gene_name": "ARP5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSRDASLTPLKAVVIDDPPLRQTPEPFDEQSAYNPQSPIAIDFGSSKLRAGFVNHATPTHIFPNALTKFRDRKLNKNFTFVGNDTLLDQAVRSQSRSPFDGPFVTNWNLTEEILDYTFHHLGVVPDNGIPNPILLTERLATVQSQRTNWYQILFETYNVPGVTFGIDSLFSFYNYNPSGNKTGLVISCGHEDTNVIPVVDGAGILTDAKRINWGGHQAVDYLNDLMALKYPYFPTKMSYLQYETMYKDYCYVSRNYDEDIEKILTLENLDTNDVVVEAPFTEVLQPQKTEEELRIQAEKRKETGKRLQEQARLKRMEKLVQKQEEFEYFSKVRDQLIDEPKKKVLSVLQNAGFDDERDFKKYLHSLEQSLKKAQMVEAEDDSHLDEMNEDKTAQKFDLLDIADEDLNEDQIKEKRKQRFLKASQDARQKAKEEKERVAKEEEEKKLKEQQWRETDLNGWIKDKRLKLNKLIKRRKEKLKLRDEMKDRKSQVSQNRMKNLASLAEDNVKQGAKRNRHQATIDNDPNDTFGANDEDWLIYTDITQNPEAFEEALEYEYKDIVELERLLLEHDPNFTEEDTLEAQYDWRNSILHLFLRGPRPHDSENIHEQHQMHLNVERIRVPEVIFQPTMGGQDQAGICELSETILLKKFGSQPGKLSQTSIDMVNNVLITGGNAKVPGLKERIVKEFTGFLPTGTNITVNMSSDPSLDAWKGMAALARNEEQYRKTVISKKEYEEYGPEYIKEHKLGNTKYFED", "length": 755 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54E71-1", "protein_name": "Actin-related protein 5", "gene_name": "arpE", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNIFAYKEIESPIDDQICKDYKTKYANPSIPIIIDNGSYQCRAGFANDISPKLIFRSLVGKVKSTSSPIVGNSLKEGDISRLTIKSPFDSNLLVHPPSQESIFDYIFHKFGIENEIENPVLITEPTSNPTFCRKYMSELLFECYNIKSVVYGIDSLFSFYGQRDQFKDGGKNSLIIGSSFNTTHIYNVQNYNVSHQQTKRINIGGGASTDYLRKLIHLKYPKHKSYFTQNYTNKIKEEHCYVSQGQYIEELKEFENDQLAKEKSVIIQLPYQEIDFEKLEEERQRKIQNRKDLGAKLRELADKKRLEKKTELEDKLASLESILALKTTNVEEFQQTLKSKSYATEKDLIRDIDDLKDKLFGKKKESEQVEDTEEFPLLFIADSELNADQLKEKKKQRQLKSMKDGRLAQKRKRDEEKEKEKEKEEERDRQEEESFLKDPEHYLKDLHSRKSKILEKREARQKQKQKANIVQRNSRLRTIVNPTNHGNYGEKGEEVEDPEEAEESREMAILDKLLNKFDPTSISSAIVSHDDQFPIGEYHTAEDFQVSLGVERIKCPETLFQPKAIIGVDQMGLVEAIISSILSQLPVDTRKLVTENIFLTGGNVNTKHFKDRIHYEIQQIREPYSPLTILKSKDSQLDAWLGARKWCLDNQDNWSNVSISKQDYQEKGYDYIKSHFASNLSLN", "length": 684 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q80US4-1", "protein_name": "Actin-related protein 5", "gene_name": "Actr5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEANVFRFRDARSAPDPVLEAGPVAFGSQPVPLVLDNGSFQARAGWACPGPDPGPEPRLQFRAVCARGRGGARGGPGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYRIPKVAYGIDSLFSFYHNVPKNALSSGLIISSGYQCTHILPVLEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILQEHSYIAEDYGAELQKWQCPDYYENNVHKMQLPFSSKLLGSTLTAEEKQERRQQQLRRLQELNARRREEKLQLDQERLERLLYVQELLEEGQMDQFHKALIELNMDSPEELQSYIQKLTLAVEQAKQKILQAEASLEVDVVDSKPETPDLEPLEPTMEDVENISDFEPLFSEETPEVEKPQVTTVQPVFNLAAYHQLSVGTERIRAPEIIFQPSLIGEEQAGIAETLHFVLDRYPKAIQDTLVQNVFLTGGNVMYPGMKARVEKELLEMRPFQSSFQVQLASNPVLDAWYGARDWALDHLEDSGAWVTRKDYEEKGGEYLKEHCASNTYVPIRLPKQASRASETQTSGRGSSASGSGAG", "length": 605 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q940Z2-1", "protein_name": "Actin-related protein 5", "gene_name": "ARP5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAFVSRIRRQSDYNTYPSSIPIVIDNGASYFRIGWAGETEPRVVFRNIVQRPRHKATGETVTIVGDLDPSMMKYFDCTRSGPRSPFDSNVVYQFEIMEYILDYAFDRLGANGSGIDHPILITECACNPVQSRSKMAELLFETYGVPAVAFGVDAAFSYKYNQLHGICKKDGIVLCPGFTTTHSIPFVDGEPIYKGSSRTNIGGYHVTDYLKQLLSLKYPFHSSRFTWEKAEDLKLEHCYIAPDYASEIRLFQEGRKEAEEKTSYWQLPWIPPPTEVPPSEEEIARKAAIREKQGQRLREMAEAKRVSKINDMENQLISLRFLLKQVDQVEEDDIPTFLSDTGYASRQELESTITKVTQSLRKARGEPKNEPAEYEENPDSLNNEKYPLMNVPDDILTPEQLKDKKRQMFLKTTAEGRLRARQKRNEEELEKEKRNQLEEERRRENPESYLEELQAQYKEVLERVEQKKRLKTNGSSNGNNKSGGIGRGERLSAAQRERMRLLTTAAFDRGKGEDTFGSRDEDWQLYKLMSKDNDDDDEQPDSDEAELARLSSRLQEIDPTFVQKVEGELSQTSGEVPRVRPLTEEDYKIVIGIERFRCPEILFHPNLIGIDQVGLDEMAGTSIRRLPHDEKELEERLTSSILMTGGCSLLPGMNERLECGIRMIRPCGSPINVVRAMDPVLDAWRGASAFAANLNFLGNAFTKMDYDEKGEDWLRNYQIRYNYL", "length": 724 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9H9F9-1", "protein_name": "Actin-related protein 5", "gene_name": "ACTR5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQLASNPVLDAWYGARDWALNHLDDNEVWITRKEYEEKGGEYLKEHCASNIYVPIRLPKQASRSSDAQASSKGSAAGGGGAGEQA", "length": 607 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VEC3-1", "protein_name": "Actin-related protein 5", "gene_name": "Arp5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAGKRVLVIDNGSYECRVGWSDSKEPDLRFRNVLTKPRKDRKKEAAASEGSASQTTVEQSAEIQVGNDITNIEAVRAHLKSPFERNVITNWNHQEQIFDYIFTKMGFDGQDKIDHPIILTEALANPNFCRQQMNELLFECYGIPSVSYGIDALYSWKHHQQKQKNISDALIISFGYSTTHVIPVLDGKLQLEHVRRLNVGGYHIITYLFRLMQMKYPVHLNAITISRMEKLVHEHCHIAVDYKEELVQWAQMDYYDEHIMKIQLPYNAVTATNAMLTAEQKQEKRRELAHRLLDIKKNREQEKLREDEQQLFVYNKLRQLYEQKKLDKFERALQQQQIGTLEDLDSLIATINSRIKRAQERAQSGPRPSKQQERLNKMPKPPEGMSQADWLAELQGKREKILGRKQARQQQRSEQAKRHTHAAQERMRIISSLAKNEKRRKANGEEEDDGFGMNDNDWDVYKRINRYNDDSDSDADNEKLMQFDKILNHYDANTDGNSNVPPQSAAENYQLHFGVENIRVPEVLFQPSMIGCSEAGLAELIAFVLKLFPAAEQQRLVEHVYLTGGCAQFKGLKERLIKELMEMRPFQSKFAIYESDEPTLSAWLGACVHAGEPTFGQTLTTRQDHQEHGREFFREHTASNIFYPTPKD", "length": 648 }, "evidence": [ { "id": "A0AAA9SR01", "url": "https://omabrowser.org/oma/group/A0AAA9SR01/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "regulation of DNA strand elongation", "id": "GO:0060382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060382", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "regulation of chromosome organization", "id": "GO:0033044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033044", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "UV-damage excision repair", "id": "GO:0070914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "positive regulation of macromolecule metabolic process", "id": "GO:0010604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "regulation of DNA metabolic process", "id": "GO:0051052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" }, { "name": "Ino80 complex", "id": "GO:0031011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031011", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme regulator activity", "id": "GO:0030234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030234", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR23-1", "uniprot_ac": "A0AAA9SR23", "uniprot_id": "A0AAA9SR23_BOVIN", "mass": { "chemical_mass": 72407.0, "monoisotopic_mass": 72407.0 }, "refseq": { "ac": "NP_001014938", "name": "leucine-rich repeat-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014938" }, "gene_names": [ { "name": "LRRC4", "type": "recommended", "evidence": [ { "id": "A0AAA9SR23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ] }, { "name": "LRRC4", "type": "synonym", "evidence": [ { "id": "NP_001014938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014938" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SR23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23/entry#names_and_taxonomy" } ] }, { "name": "leucine rich repeat containing 4 protein", "type": "synonym", "evidence": [ { "id": "NP_001014938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014938" } ] }, { "name": "leucine-rich repeat-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001014938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014938" } ] }, { "name": "netrin-G1 ligand", "type": "synonym", "evidence": [ { "id": "NP_001014938", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014938" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23", "locus": { "chromosome": "4", "start_pos": 92229402, "end_pos": 92236125, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010704", "url": "https://www.ensembl.org/id/ENSBTAG00000010704" } ] } } ], "crossref": [ { "id": "525767", "url": "https://www.ncbi.nlm.nih.gov/gene/525767", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525767", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525767", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014938", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLLWQVTVHHTWNAVLLPVVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLGSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPLHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVTATDTNDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDDDIPAAAPAAATAAPAGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPAVTTISEPYIIQTHTKDKVQETQI", "length": 652, "header": "tr|A0AAA9SR23-1|A0AAA9SR23_BOVIN Isoform 1 of Leucine rich repeat containing 4 OS=Bos taurus OX=9913 GN=LRRC4 PE=4 SV=1 CANONICAL=A0AAA9SR23-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23/entry#A0AAA9SR23-1", "sequence": { "sequence": "MKLLWQVTVHHTWNAVLLPVVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLGSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPLHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVTATDTNDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDDDIPAAAPAAATAAPAGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPAVTTISEPYIIQTHTKDKVQETQI", "length": 652, "header": "tr|A0AAA9SR23-1|A0AAA9SR23_BOVIN Isoform 1 of Leucine rich repeat containing 4 OS=Bos taurus OX=9913 GN=LRRC4 PE=4 SV=1 CANONICAL=A0AAA9SR23-1" }, "locus": { "chromosome": "4", "start_pos": 92233222, "end_pos": 92231267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092461.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092461.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088795.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525767", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525767", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" }, { "name": "excitatory synapse", "id": "GO:0060076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SR23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR23" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 352, "end_pos": 441, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 446, "end_pos": 448 }, { "start_pos": 449, "end_pos": 451 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR42-1", "uniprot_ac": "A0AAA9SR42", "uniprot_id": "A0AAA9SR42_BOVIN", "mass": { "chemical_mass": 36514.0, "monoisotopic_mass": 36514.0 }, "refseq": { "ac": "XP_003587857", "name": "testisin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587857" }, "gene_names": [ { "name": "LOC617302", "type": "recommended", "evidence": [ { "id": "A0AAA9SR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42" } ] }, { "name": "LOC617302", "type": "synonym", "evidence": [ { "id": "XP_003587857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587857" } ] } ], "protein_names": [ { "name": "Peptidase S1 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42/entry#names_and_taxonomy" } ] }, { "name": "testisin", "type": "synonym", "evidence": [ { "id": "XP_003587857", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587857" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC617302", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42", "locus": {} } ], "crossref": [ { "id": "A0AAA9SR42", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR42", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617302", "url": "https://www.ncbi.nlm.nih.gov/gene/617302", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617302", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617302", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587857", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587857", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SR42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPQGAALLLAQLLVRIEIAEQALRDKDLLLPGLQNSSMLAWPCGIQGIQVRVVGGNEAKLGRWPWQGSLRWNKVHSCGASLLNRRWALSAAHCFEKNSYPSEWSVQFGELSATPSIWSLRAFLRRYGVQDIITFSQFRKNFQHDIALVKLSSPVTFNKHVQPVCVTSSSLEFKNRNDCWVTGWGNIGERQKLLPPYNLREVQVSIINKSRCSYLFQQPLYRRNINHGMICAGSEDGDADSCKGDSGGPLVCEKNGRWIQIGIVSWGVGCGRRNRPGVYTNVSHYFSWIQLLTARSTPRPDPSWLLLPLALLWTLLLLQMACAH", "length": 324, "header": "tr|A0AAA9SR42-1|A0AAA9SR42_BOVIN Isoform 1 of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN=LOC617302 PE=4 SV=1 CANONICAL=A0AAA9SR42-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42/entry#A0AAA9SR42-1", "sequence": { "sequence": "MRPQGAALLLAQLLVRIEIAEQALRDKDLLLPGLQNSSMLAWPCGIQGIQVRVVGGNEAKLGRWPWQGSLRWNKVHSCGASLLNRRWALSAAHCFEKNSYPSEWSVQFGELSATPSIWSLRAFLRRYGVQDIITFSQFRKNFQHDIALVKLSSPVTFNKHVQPVCVTSSSLEFKNRNDCWVTGWGNIGERQKLLPPYNLREVQVSIINKSRCSYLFQQPLYRRNINHGMICAGSEDGDADSCKGDSGGPLVCEKNGRWIQIGIVSWGVGCGRRNRPGVYTNVSHYFSWIQLLTARSTPRPDPSWLLLPLALLWTLLLLQMACAH", "length": 324, "header": "tr|A0AAA9SR42-1|A0AAA9SR42_BOVIN Isoform 1 of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN=LOC617302 PE=4 SV=1 CANONICAL=A0AAA9SR42-1" }, "locus": { "chromosome": "25", "start_pos": 2267455, "end_pos": 2255646, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121713.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121713.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086446.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086446.1" } ] } }, { "isoform_ac": "A0AAA9T4W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42/entry#A0AAA9T4W4-1", "sequence": { "sequence": "MSLPPAAQPSVRLSIPGPCGIQGIQVRVVGGNEAKLGRWPWQGSLRWNKVHSCGASLLNRRWALSAAHCFEKNSYPSEWSVQFGELSATPSIWSLRAFLRRYGVQDIITFSQFRKNFQHDIALVKLSSPVTFNKHVQPVCVTSSSLEFKNRNDCWVTGWGNIGERQKLLPPYNLREVQVSIINKSRCSYLFQQPLYRRNINHGMICAGSEDGDADSCKGDSGGPLVCEKNGRWIQIGIVSWGVGCGRRNRPGVYTNVSHYFSWIQLLTARSTPRPDPSWLLLPLALLWTLLLLQMACAH", "length": 299, "header": "tr|A0AAA9T4W4-1|A0AAA9T4W4_BOVIN Computationally mapped isoform of Peptidase S1 domain-containing protein OS=Bos taurus OX=9913 GN=LOC617302 PE=4 SV=1 CANONICAL=A0AAA9SR42-1" }, "locus": { "chromosome": "25", "start_pos": 2267455, "end_pos": 2256120, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113222.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113222.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090768.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090768.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617302", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617302", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR42" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 294, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 }, { "start_pos": 281, "end_pos": 283 }, { "start_pos": 36, "end_pos": 38 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR52-1", "uniprot_ac": "A0AAA9SR52", "uniprot_id": "A0AAA9SR52_BOVIN", "mass": { "chemical_mass": 38751.0, "monoisotopic_mass": 38751.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "PI-PLC X domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SR52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52", "locus": {} } ], "crossref": [ { "id": "A0AAA9SR52", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR52", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13593:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13593:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SR52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCPSVSASLTDHRVFKVHPRCSLCQNFTPFHGDSYTTVAAWGHRGQAQGVMCPPPGLPAGSHSMMTYCLNKKSPISHKESRLLQTLGKVLPCVTLPVVLKRSTTQVRVCGHARALDPDLQMAHMEEGTERNLHSGHMVYMTALTEDMLTEISEWLENHPQEVVILACRNFKGVMEDLHEYLMGCIKNIFGDMLCPMGCEQGPQMLTLHQLWSQGQQVILSYKDEASVSQHAELWPGIPYWWGNQVKPRDLVHHLELMKSCSHPGELMVAGINLSENLEFVRVHPAWSLEKLTQWGLPYLCAWVRGQCPGSATGRTNTVAGEFIWADGFVGDVIGLNWKLLGADGRRT", "length": 347, "header": "tr|A0AAA9SR52-1|A0AAA9SR52_BOVIN Isoform 1 of PI-PLC X domain-containing protein 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SR52-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52/entry#A0AAA9SR52-1", "sequence": { "sequence": "MCPSVSASLTDHRVFKVHPRCSLCQNFTPFHGDSYTTVAAWGHRGQAQGVMCPPPGLPAGSHSMMTYCLNKKSPISHKESRLLQTLGKVLPCVTLPVVLKRSTTQVRVCGHARALDPDLQMAHMEEGTERNLHSGHMVYMTALTEDMLTEISEWLENHPQEVVILACRNFKGVMEDLHEYLMGCIKNIFGDMLCPMGCEQGPQMLTLHQLWSQGQQVILSYKDEASVSQHAELWPGIPYWWGNQVKPRDLVHHLELMKSCSHPGELMVAGINLSENLEFVRVHPAWSLEKLTQWGLPYLCAWVRGQCPGSATGRTNTVAGEFIWADGFVGDVIGLNWKLLGADGRRT", "length": 347, "header": "tr|A0AAA9SR52-1|A0AAA9SR52_BOVIN Isoform 1 of PI-PLC X domain-containing protein 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SR52-1" }, "locus": { "chromosome": "X", "start_pos": 133053469, "end_pos": 133046266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088476.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088476.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087824.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087824.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphoric diester hydrolase activity", "id": "GO:0008081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008081", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR52" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 26, "end_pos": 28 }, { "start_pos": 272, "end_pos": 274 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SR86-1", "uniprot_ac": "A0AAA9SR86", "uniprot_id": "A0AAA9SR86_BOVIN", "mass": { "chemical_mass": 14373.0, "monoisotopic_mass": 14373.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Histone H2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SR86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86#function" }, { "database": "UniProtKB", "id": "ARBA00002001", "url": "https://www.uniprot.org/uniprotkb/ARBA00002001#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86", "locus": {} } ], "crossref": [ { "id": "A0AAA9SR86", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SR86", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00074", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00074", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16211", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16211", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGNTPP", "length": 133, "header": "tr|A0AAA9SR86-1|A0AAA9SR86_BOVIN Isoform 1 of Histone H2A OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SR86-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86/entry#A0AAA9SR86-1", "sequence": { "sequence": "MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGNTPP", "length": 133, "header": "tr|A0AAA9SR86-1|A0AAA9SR86_BOVIN Isoform 1 of Histone H2A OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SR86-1" }, "locus": { "chromosome": "23", "start_pos": 31828623, "end_pos": 31766348, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094422.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094422.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086491.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086491.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SR86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" }, { "id": "PF00125", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Core Histone H2A/H2B/H3", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 89, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SR86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR86" }, { "id": "PF16211", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone H2A C-terminal", "eco_id": "ECO_0000259", "start_pos": 92, "end_pos": 126, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRA4-1", "uniprot_ac": "A0AAA9SRA4", "uniprot_id": "A0AAA9SRA4_BOVIN", "mass": { "chemical_mass": 66580.0, "monoisotopic_mass": 66580.0 }, "refseq": {}, "gene_names": [ { "name": "TRIM16", "type": "recommended", "evidence": [ { "id": "A0AAA9SRA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ] } ], "protein_names": [ { "name": "Tripartite motif containing 16", "type": "synonym", "evidence": [ { "id": "A0AAA9SRA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4", "locus": { "chromosome": "19", "start_pos": 33033493, "end_pos": 33061188, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002605", "url": "https://www.ensembl.org/id/ENSBTAG00000002605" } ] } } ], "crossref": [ { "id": "A0AAA9SRA4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRA4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002605", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002605", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12890", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12890", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100848152", "url": "https://www.ncbi.nlm.nih.gov/gene/100848152", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848152", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848152", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SAWHSGV", "url": "https://omabrowser.org/oma/group/SAWHSGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLX8", "url": "https://www.orthodb.org/?gene=F1MLX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25465:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25465:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8P5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8P5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLX8", "url": "https://www.uniprot.org/uniprotkb/F1MLX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MLX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELDLMAPGPLCGVPAHPPAALSPDSGSASPAEEENPGSPGSPPGETGETGGQGSEWQGAPKAEGLEEEEEVLCDFCLGASRVRAVKSCLTCMVNYCPEHLRPHQENSRLHGHQLTEPARDRDLRVCPAHRSPLIAYCDPDGQCICEECSQAEHRGHALVSLDAARRAKEAELRRTQLDLERKLKLNENAISRLQANHKSVLVPLSMALPRQESWSGSPCPPSGDLLDPGIVLKSLASPALVSVSEVKAGVEEQFGELRAALTKAQADVMLFLEEKEQAALGQANGIKTHLEYRSAEMEKARQELDRIAAIGSPVLFLEEYCKFKNTEDGAFPSVYIGLKDKLSGIHKVIMDSTALLIQLLQSYKEKLQEFSKDEEYDIRTQVCAVIEHRHRTSEPEPCSRQQLLQYACDIVFDPDTAHRYLRLQDDNRKVTNTAPWEHPYPDLPSRFSHWRQVLAQQSLYLHRYYFEVELSGAGVYVGLTCQGIDRKGEERNSCISGNDFSWSLHWDGKGFRAWHSDAETLLSANACRRLGVYVDFPGGGLSFYGVEPETLTLLHRFQCKFSEPVYPAFWLSKKDSAIRIADLGEEPEKPGPAPVEAAA", "length": 601, "header": "tr|A0AAA9SRA4-1|A0AAA9SRA4_BOVIN Isoform 1 of Tripartite motif containing 16 OS=Bos taurus OX=9913 GN=TRIM16 PE=4 SV=1 CANONICAL=A0AAA9SRA4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4/entry#A0AAA9SRA4-1", "sequence": { "sequence": "MAELDLMAPGPLCGVPAHPPAALSPDSGSASPAEEENPGSPGSPPGETGETGGQGSEWQGAPKAEGLEEEEEVLCDFCLGASRVRAVKSCLTCMVNYCPEHLRPHQENSRLHGHQLTEPARDRDLRVCPAHRSPLIAYCDPDGQCICEECSQAEHRGHALVSLDAARRAKEAELRRTQLDLERKLKLNENAISRLQANHKSVLVPLSMALPRQESWSGSPCPPSGDLLDPGIVLKSLASPALVSVSEVKAGVEEQFGELRAALTKAQADVMLFLEEKEQAALGQANGIKTHLEYRSAEMEKARQELDRIAAIGSPVLFLEEYCKFKNTEDGAFPSVYIGLKDKLSGIHKVIMDSTALLIQLLQSYKEKLQEFSKDEEYDIRTQVCAVIEHRHRTSEPEPCSRQQLLQYACDIVFDPDTAHRYLRLQDDNRKVTNTAPWEHPYPDLPSRFSHWRQVLAQQSLYLHRYYFEVELSGAGVYVGLTCQGIDRKGEERNSCISGNDFSWSLHWDGKGFRAWHSDAETLLSANACRRLGVYVDFPGGGLSFYGVEPETLTLLHRFQCKFSEPVYPAFWLSKKDSAIRIADLGEEPEKPGPAPVEAAA", "length": 601, "header": "tr|A0AAA9SRA4-1|A0AAA9SRA4_BOVIN Isoform 1 of Tripartite motif containing 16 OS=Bos taurus OX=9913 GN=TRIM16 PE=4 SV=1 CANONICAL=A0AAA9SRA4-1" }, "locus": { "chromosome": "19", "start_pos": 33049192, "end_pos": 33034497, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124396.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124396.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088869.1" } ] } }, { "isoform_ac": "A0AAA9T8P5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4/entry#A0AAA9T8P5-1", "sequence": { "sequence": "MVNYCPEHLRPHQENSRLHGHQLTEPARDRDLRVCPAHRSPLIAYCDPDGQCICEECSQAEHRGHALVSLDAARRAKEAELRRTQLDLERKLKLNENAISRLQANHKSVLVPLSMALPRQESWSGSPCPPSGDLLDPGIVLKSLASPALVSVSEVKAGVEEQFGELRAALTKAQADVMLFLEEKEQAALGQANGIKTHLEYRSAEMEKARQELDRIAAIGSPVLFLEEYCKFKNTEDGAFPSVYIGLKDKLSGIHKVIMDSTALLIQLLQSYKEKLQEFSKDEEYDIRTQVCAVIEHRHRTSEPEPCSRQQLLQYACDIVFDPDTAHRYLRLQDDNRKVTNTAPWEHPYPDLPSRFSHWRQVLAQQSLYLHRYYFEVELSGAGVYVGLTCQGIDRKGEERNSCISGNDFSWSLHWDGKGFRAWHSDAETLLSANACRRLGVYVDFPGGGLSFYGVEPETLTLLHRFQCKFSEPVYPAFWLSKKDSAIRIADLGEEPEKPGPAPVEAAA", "length": 508, "header": "tr|A0AAA9T8P5-1|A0AAA9T8P5_BOVIN Computationally mapped isoform of Tripartite motif containing 16 OS=Bos taurus OX=9913 GN=TRIM16 PE=4 SV=1 CANONICAL=A0AAA9SRA4-1" }, "locus": { "chromosome": "19", "start_pos": 33048913, "end_pos": 33034497, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132134.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132134.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094336.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094336.1" } ] } }, { "isoform_ac": "F1MLX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4/entry#F1MLX8-1", "sequence": { "sequence": "MAELDLMAPGPLCGVPAHPPAALSPDSGSASPAEEENPGSPGSPPGETGETGGQGSEWQGAPKAEGLEEEEEVLCDFCLGASRVRAVKSCLTCMVNYCPEHLRPHQENSRLHGHQLTEPARDRDLRVCPAHRSPLIAYCDPDGQCICEECSQAEHRGHALVSLDAARRAKEAELRRTQLDLERKLKLNENAISRLQANHKSVLVSVSEVKAGVEEQFGELRAALTKAQADVMLFLEEKEQAALGQANGIKTHLEYRSAEMEKARQELDRIAAIGSPVLFLEEYCKFKNTEDGAFPSVYIGLKDKLSGIHKVIMDSTALLIQLLQSYKEKLQEFSKDEEYDIRTQVCAVIEHRHRTSEPEPCSRQQLLQYACDIVFDPDTAHRYLRLQDDNRKVTNTAPWEHPYPDLPSRFSHWRQVLAQQSLYLHRYYFEVELSGAGVYVGLTCQGIDRKGEERNSCISGNDFSWSLHWDGKGFRAWHSDAETLLSANACRRLGVYVDFPGGGLSFYGVEPETLTLLHRFQCKFSEPVYPAFWLSKKDSAIRIADLGEEPEKPGPAPVEAAA", "length": 562, "header": "tr|F1MLX8-1|A0AAA9SRA4_BOVIN Computationally mapped isoform of Tripartite motif containing 16 OS=Bos taurus OX=9913 GN=TRIM16 PE=4 SV=3 CANONICAL=A0AAA9SRA4-1" }, "locus": { "chromosome": "19", "start_pos": 33049192, "end_pos": 33034497, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003367.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003367.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003367.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003367.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848152", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848152", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BSK0-1", "protein_name": "Tripartite motif containing 16", "gene_name": "TRIM16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAELELMAPGPLPGVPTHPPATLSPDLASASLAEEDSASLGEEEDSASLESPPGESGGQGSGSADSAGQEGPKAEGEEEEVLCDFCLGASRVRAVKSCLTCMVNYCPEHLRPHQENSKLHGHQLTEPTKDRDLRVCPAHRSPLVAFCCSDGQCICRECGQGEHRGHTLVSLDTARRDKETELQNTQLDLEQKLKLNENAIARLQDNHKSVLVSVSEVKAVAEEQFGELLAAVRKAQADAMLFLEEKEQAALGQASGIKTHLECRSAEMERTRQELDRIAAISNPVLFLEEYCQFKHTEDGAFPSVYIGLKDRLSGIRKVITDSTAHLIQLLQDYKARLQEFSKEGEFDIRTQVSAIIEHKHRASRPEPSTRPQFLQYACDIAFDPDTAHRYLRLQEDNRKVTNTAPWEHPYPDLPSRFTHWRQVLAQQSLYLHRYYFELELSGAGVYVGLTCKGIDRKGEERNSCISGNSFSWSLHWDGKAFRAWHSDTETPLKASPCRRLGVYVDSPGGVLSFYGVEPDAMTLVHRFDCRFSEPVYPAFWLSKKEDAIRIVDLGEELGKPAPTSVEAAP", "length": 570 }, "evidence": [ { "id": "A0AAA9SRA4", "url": "https://omabrowser.org/oma/group/A0AAA9SRA4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95361-1", "protein_name": "Tripartite motif-containing protein 16", "gene_name": "TRIM16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP", "length": 564 }, "evidence": [ { "id": "A0AAA9SRA4", "url": "https://omabrowser.org/oma/group/A0AAA9SRA4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99PP9-1", "protein_name": "Tripartite motif-containing protein 16", "gene_name": "Trim16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELDLIAPGPLTGVTAHPLAPLGPDPVSAIPVEKEDADPLSKSGEETQEQGHDPAELGAPGEEDQILCDFCLGASRVRAVKSCLTCMVNYCEEHLRPHQENSKLHSHQLTEPAKDQDLRTCPAHHSPLVSFCHTHQQCICQECGEGEHRGDSTVSLDAARRNKEVDLRCMQLDLEQKLKLNENAIARLQANHKSVLVSVSEVKVVAEEKFGELLAAVRKAQADVMVFLEEKEQAALNQVNSIKTHLEHRSLEMEKSKQELERLAAISNTVLFLEEYCKLKKTEDTASPSIYIGLKDKLSGIRKVITDSTLNLIQLLESYKEKLQEFSREEEYDIRTQVSAIVQRKYRTSKPEPRTRDEFLQYACDITFDPDTAHRYLRLQEDNRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVELSGGGTYVGLTCKGIDRKGEERNSCISGNSFSWSIHWNGKEFTAWHSDTETPLKVSPFRRLGIYVNFPGGILSFYGVEYDAMTLIHKFDCKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAGSSVEAAP", "length": 556 }, "evidence": [ { "id": "A0AAA9SRA4", "url": "https://omabrowser.org/oma/group/A0AAA9SRA4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "interleukin-1 binding", "id": "GO:0019966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "NACHT domain binding", "id": "GO:0032089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032089", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "response to retinoic acid", "id": "GO:0032526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032526", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "response to growth hormone", "id": "GO:0060416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "positive regulation of interleukin-1 beta production", "id": "GO:0032731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "positive regulation of retinoic acid receptor signaling pathway", "id": "GO:0048386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" }, { "name": "positive regulation of keratinocyte differentiation", "id": "GO:0045618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045618", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 123, "end_pos": 163, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SRA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRA4" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 392, "end_pos": 590, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRB3-1", "uniprot_ac": "A0AAA9SRB3", "uniprot_id": "A0AAA9SRB3_BOVIN", "mass": { "chemical_mass": 63136.0, "monoisotopic_mass": 63136.0 }, "refseq": {}, "gene_names": [ { "name": "NECTIN4", "type": "recommended", "evidence": [ { "id": "A0AAA9SRB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ] } ], "protein_names": [ { "name": "Nectin-4", "type": "recommended", "evidence": [ { "id": "A0AAA9SRB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#names_and_taxonomy" } ] }, { "name": "Nectin cell adhesion molecule 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SRB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#names_and_taxonomy" } ] }, { "name": "Poliovirus receptor-related protein 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SRB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NECTIN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3", "locus": { "chromosome": "3", "start_pos": 8418913, "end_pos": 8391138, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017877", "url": "https://www.ensembl.org/id/ENSBTAG00000017877" } ] } } ], "crossref": [ { "id": "A0AAA9SRB3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017877", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017877", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05888", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05888", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07704", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07704", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MD92", "url": "https://www.orthodb.org/?gene=A0A3Q1MD92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23277", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23277", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23277:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23277:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MD92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP94", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP94-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM38", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMSVELRPRRASSSERPLLFKLRIHLGLRRFRCRRCSANIEEEPCAFDFSIFWGSGGEGEEACHLACGILVSQQGCNVRPRQWKPGVFTTGQPGQRLAGELETSDLVTVVLGQDAKLPCFYRGDPGEQVEQVAWARVDAGEGGRELALLNSKYGLHVSSAYEGRVEQPPPPRNPLDGAVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTASHRSFTHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILQVAFLAEASVRGLEDRKLWQVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRAEGDTLGFPTLTPEHSGTYVCRVSNALSSRDSQVVVDVLDPEDAPGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRNQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELPSPGPGRAEEEEDRDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV", "length": 577, "header": "tr|A0AAA9SRB3-1|A0AAA9SRB3_BOVIN Isoform 1 of Nectin-4 OS=Bos taurus OX=9913 GN=NECTIN4 PE=3 SV=1 CANONICAL=A0AAA9SRB3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MD92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#A0A3Q1MD92-1", "sequence": { "sequence": "MPLSLGAEMWGPAAWLLLLLLLASFTGQRLAGELETSDLVTVVLGQDAKLPCFYRGDPGEQVEQVAWARVDAGEGGRELALLNSKYGLHVSSAYEGRVEQPPPPRNPLDGAVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTASHRSFTHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILQVAFLAEASVRGLEDRKLWQVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRAEGDTLGFPTLTPEHSGTYVCRVSNALSSRDSQVVVDVLGKHGGKGWDLGQGPGGVNGKQDRVNWESVYLEGSGLCVFLRGQAEGVVWDVSRADRVGRAGDLDVCLRARPAPSRPRGRPREAGGPRAPDSPPALGLQSEEPEGRSYSTLTTVREIETQTELPSPGPGRAEEEEDRDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV", "length": 505, "header": "tr|A0A3Q1MD92-1|A0A3Q1MD92_BOVIN Computationally mapped isoform of Nectin-4 OS=Bos taurus OX=9913 GN=NECTIN4 PE=3 SV=1 CANONICAL=A0AAA9SRB3-1" }, "locus": { "chromosome": "3", "start_pos": 8417909, "end_pos": 8403389, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078120.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078120.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068883.1" } ] } }, { "isoform_ac": "A0AAA9SRB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#A0AAA9SRB3-1", "sequence": { "sequence": "MMSVELRPRRASSSERPLLFKLRIHLGLRRFRCRRCSANIEEEPCAFDFSIFWGSGGEGEEACHLACGILVSQQGCNVRPRQWKPGVFTTGQPGQRLAGELETSDLVTVVLGQDAKLPCFYRGDPGEQVEQVAWARVDAGEGGRELALLNSKYGLHVSSAYEGRVEQPPPPRNPLDGAVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTASHRSFTHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILQVAFLAEASVRGLEDRKLWQVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRAEGDTLGFPTLTPEHSGTYVCRVSNALSSRDSQVVVDVLDPEDAPGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRNQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELPSPGPGRAEEEEDRDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV", "length": 577, "header": "tr|A0AAA9SRB3-1|A0AAA9SRB3_BOVIN Isoform 1 of Nectin-4 OS=Bos taurus OX=9913 GN=NECTIN4 PE=3 SV=1 CANONICAL=A0AAA9SRB3-1" }, "locus": { "chromosome": "3", "start_pos": 8417909, "end_pos": 8391155, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094204.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094204.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086517.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086517.1" } ] } }, { "isoform_ac": "A0AAA9TL27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#A0AAA9TL27-1", "sequence": { "sequence": "MSKVKASRLCEVLARGQRLAGELETSDLVTVVLGQDAKLPCFYRGDPGEQVEQVAWARVDAGEGGRELALLNSKYGLHVSSAYEGRVEQPPPPRNPLDGAVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTASHRSFTHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILQVAFLAEASVRGLEDRKLWQVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRAEGDTLGFPTLTPEHSGTYVCRVSNALSSRDSQVVVDVLDPEDAPGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRNQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELPSPGPGRAEEEEDRDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV", "length": 499, "header": "tr|A0AAA9TL27-1|A0AAA9TL27_BOVIN Computationally mapped isoform of Nectin-4 OS=Bos taurus OX=9913 GN=NECTIN4 PE=3 SV=1 CANONICAL=A0AAA9SRB3-1" }, "locus": { "chromosome": "3", "start_pos": 8417909, "end_pos": 8410240, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089180.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089180.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097654.1" } ] } }, { "isoform_ac": "A0AAA9TP94-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#A0AAA9TP94-1", "sequence": { "sequence": "MPLSLGAEMWGPAAWLLLLLLLASFTGQRLAGELETSDLVTVVLGQDAKLPCFYRGDPGEQVEQVAWARVDAGEGGRELALLNSKYGLHVSSAYEGRVEQPPPPRNPLDGAVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTASHRSFTHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILQVAFLAEASVRGLEDRKLWQVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRAEGDTLGFPTLTPEHSGTYVCRVSNALSSRDSQVVVDVLGKHGGKGWDLGQGPGGVNGKQDRVNWESVYLEGSGLCVFLRGQAEGVVWDVSRADRVGRAGDLDVCLRARPAPSRPRGRPREAGGPRVGLRGGGGRDRRALVLPSRGGRGAHVPIPSAQGPADDPEIVSTGPSRAGEVSGEQRGDKQEVGQD", "length": 485, "header": "tr|A0AAA9TP94-1|A0AAA9TP94_BOVIN Computationally mapped isoform of Nectin-4 OS=Bos taurus OX=9913 GN=NECTIN4 PE=3 SV=2 CANONICAL=A0AAA9SRB3-1" }, "locus": { "chromosome": "3", "start_pos": 8416562, "end_pos": 8403389, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118404.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118404.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098175.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098175.2" } ] } }, { "isoform_ac": "A0AAF6DM38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3/entry#A0AAF6DM38-1", "sequence": { "sequence": "MPLSLGAEMWGPAAWLLLLLLLASFTGQRLAGELETSDLVTVVLGQDAKLPCFYRGDPGEQVEQVAWARVDAGEGGRELALLNSKYGLHVSSAYEGRVEQPPPPRNPLDGAVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTASHRSFTHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILQVAFLAEASVRGLEDRKLWQVGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRAEGDTLGFPTLTPEHSGTYVCRVSNALSSRDSQVVVDVLADPEDAPGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRNQSEEPEGRSYSTLTTVREIETQTELPSPGPGRAEEEEDRDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV", "length": 486, "header": "tr|A0AAF6DM38-1|A0AAF6DM38_BOVIN Computationally mapped isoform of Nectin-4 OS=Bos taurus OX=9913 GN=NECTIN4 PE=3 SV=1 CANONICAL=A0AAA9SRB3-1" }, "locus": { "chromosome": "3", "start_pos": 8417909, "end_pos": 8403389, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023767.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023767.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023767.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023767.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" }, { "name": "symbiont entry into host cell", "id": "GO:0046718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046718", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" }, { "name": "negative regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045953", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRB3" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 85, "end_pos": 211, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 348, "end_pos": 350 }, { "start_pos": 497, "end_pos": 499 }, { "start_pos": 556, "end_pos": 558 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRE2-1", "uniprot_ac": "A0AAA9SRE2", "uniprot_id": "A0AAA9SRE2_BOVIN", "mass": { "chemical_mass": 53897.0, "monoisotopic_mass": 53897.0 }, "refseq": {}, "gene_names": [ { "name": "ZSCAN21", "type": "recommended", "evidence": [ { "id": "A0AAA9SRE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain containing 21", "type": "synonym", "evidence": [ { "id": "A0AAA9SRE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSCAN21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2", "locus": { "chromosome": "25", "start_pos": 36387593, "end_pos": 36395341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060579", "url": "https://www.ensembl.org/id/ENSBTAG00000060579" } ] } } ], "crossref": [ { "id": "A0AAA9SRE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVLGMATVLGPRPPQEQGPVIVKIEEEEEKGKRLPMEIFRQRFRQFGYHDTPGPREALSQLRVLCCEWLRPEIHTKEQILELLVLEQFLTILPQELQAWVQEHCPESAEEAVTLLEDLERELDEPAPQVSPPPREQKRSWEKMSPSGMAEESLSSPQLESVETSHRYESWGPLYIQETGEEEKFTPALRKVRDRKSKTQNEESTDKEGSSEESHAEGFRRDTLPMIITDKCEARLERQWVNPEKERGTKTPLQDKGSAKGREVVTKPAPGERRYICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKCGKAFSHSSNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTEEAPYQCKDCGKAFSGKGSLIRHYRIHTGEKPYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNHSSNFNKHHRIHTGEKPYWCSDCGKTFCSKSNLSKHQKVHIVEGEGS", "length": 471, "header": "tr|A0AAA9SRE2-1|A0AAA9SRE2_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 21 OS=Bos taurus OX=9913 GN=ZSCAN21 PE=3 SV=1 CANONICAL=A0AAA9SRE2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2/entry#A0AAA9SRE2-1", "sequence": { "sequence": "MKVLGMATVLGPRPPQEQGPVIVKIEEEEEKGKRLPMEIFRQRFRQFGYHDTPGPREALSQLRVLCCEWLRPEIHTKEQILELLVLEQFLTILPQELQAWVQEHCPESAEEAVTLLEDLERELDEPAPQVSPPPREQKRSWEKMSPSGMAEESLSSPQLESVETSHRYESWGPLYIQETGEEEKFTPALRKVRDRKSKTQNEESTDKEGSSEESHAEGFRRDTLPMIITDKCEARLERQWVNPEKERGTKTPLQDKGSAKGREVVTKPAPGERRYICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKCGKAFSHSSNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTEEAPYQCKDCGKAFSGKGSLIRHYRIHTGEKPYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNHSSNFNKHHRIHTGEKPYWCSDCGKTFCSKSNLSKHQKVHIVEGEGS", "length": 471, "header": "tr|A0AAA9SRE2-1|A0AAA9SRE2_BOVIN Isoform 1 of Zinc finger and SCAN domain containing 21 OS=Bos taurus OX=9913 GN=ZSCAN21 PE=3 SV=1 CANONICAL=A0AAA9SRE2-1" }, "locus": { "chromosome": "25", "start_pos": 36390736, "end_pos": 36387993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086641.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" }, { "name": "male meiosis I", "id": "GO:0007141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007141", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 302, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SRE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE2" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 123, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 }, { "start_pos": 289, "end_pos": 291 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 456, "end_pos": 458 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRF1-1", "uniprot_ac": "A0AAA9SRF1", "uniprot_id": "A0AAA9SRF1_BOVIN", "mass": { "chemical_mass": 21611.0, "monoisotopic_mass": 21611.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC195", "type": "recommended", "evidence": [ { "id": "A0AAA9SRF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 195", "type": "synonym", "evidence": [ { "id": "A0AAA9SRF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC195", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1", "locus": { "chromosome": "2", "start_pos": 112814695, "end_pos": 112826967, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062054", "url": "https://www.ensembl.org/id/ENSBTAG00000062054" } ] } } ], "crossref": [ { "id": "A0AAA9SRF1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRF1", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SRF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAANIHLMRVIQEMRAEIHKLEKENQALRMKLTLSSQRTPGSGGESGDEKEEEVPGQSPAALHGGVASDSAPGVREHQGNVMIVRRYSISSPIHSSTTSDPWKTRRRHPNCGILEVQGTVKSLASSVKKQNNEEKMFTSDSFTTNGCSKGVFPEHNFGYRDKRKTVGFLLPMNTSSHSKDSSSLKYSPNQLSTIIE", "length": 196, "header": "tr|A0AAA9SRF1-1|A0AAA9SRF1_BOVIN Isoform 1 of Coiled-coil domain containing 195 OS=Bos taurus OX=9913 GN=CCDC195 PE=4 SV=1 CANONICAL=A0AAA9SRF1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRF1/entry#A0AAA9SRF1-1", "sequence": { "sequence": "MAANIHLMRVIQEMRAEIHKLEKENQALRMKLTLSSQRTPGSGGESGDEKEEEVPGQSPAALHGGVASDSAPGVREHQGNVMIVRRYSISSPIHSSTTSDPWKTRRRHPNCGILEVQGTVKSLASSVKKQNNEEKMFTSDSFTTNGCSKGVFPEHNFGYRDKRKTVGFLLPMNTSSHSKDSSSLKYSPNQLSTIIE", "length": 196, "header": "tr|A0AAA9SRF1-1|A0AAA9SRF1_BOVIN Isoform 1 of Coiled-coil domain containing 195 OS=Bos taurus OX=9913 GN=CCDC195 PE=4 SV=1 CANONICAL=A0AAA9SRF1-1" }, "locus": { "chromosome": "2", "start_pos": 112826967, "end_pos": 112814698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114674.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114674.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086554.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRG8-1", "uniprot_ac": "A0AAA9SRG8", "uniprot_id": "A0AAA9SRG8_BOVIN", "mass": { "chemical_mass": 27746.0, "monoisotopic_mass": 27746.0 }, "refseq": {}, "gene_names": [ { "name": "ZCCHC24", "type": "recommended", "evidence": [ { "id": "A0AAA9SRG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8" } ] } ], "protein_names": [ { "name": "Zinc finger CCHC-type containing 24", "type": "synonym", "evidence": [ { "id": "A0AAA9SRG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZCCHC24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8", "locus": { "chromosome": "28", "start_pos": 34988422, "end_pos": 35050587, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003877", "url": "https://www.ensembl.org/id/ENSBTAG00000003877" } ] } } ], "crossref": [ { "id": "A0AAA9SRG8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003877", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003877", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616669", "url": "https://www.ncbi.nlm.nih.gov/gene/616669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616669", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616669", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTEYSPG", "url": "https://omabrowser.org/oma/group/CTEYSPG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BIP9", "url": "https://www.orthodb.org/?gene=E1BIP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF13696", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13696", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17180", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17180", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23490", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23490", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIP9", "url": "https://www.uniprot.org/uniprotkb/E1BIP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BIP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSGQSRPPAPRPQSWPSARAAQSSWARPCTPAISTASSSCSAERSQREKRPREGKGWARVEEQGVQRAKKSEGCVLQGSAGPPEAYMCEALSSSVYKSASPYGSLNNIADGLSSLTEHFSDLTLASETRKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 249, "header": "tr|A0AAA9SRG8-1|A0AAA9SRG8_BOVIN Isoform 1 of Zinc finger CCHC-type containing 24 OS=Bos taurus OX=9913 GN=ZCCHC24 PE=4 SV=1 CANONICAL=A0AAA9SRG8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8/entry#A0AAA9SRG8-1", "sequence": { "sequence": "MPSGQSRPPAPRPQSWPSARAAQSSWARPCTPAISTASSSCSAERSQREKRPREGKGWARVEEQGVQRAKKSEGCVLQGSAGPPEAYMCEALSSSVYKSASPYGSLNNIADGLSSLTEHFSDLTLASETRKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 249, "header": "tr|A0AAA9SRG8-1|A0AAA9SRG8_BOVIN Isoform 1 of Zinc finger CCHC-type containing 24 OS=Bos taurus OX=9913 GN=ZCCHC24 PE=4 SV=1 CANONICAL=A0AAA9SRG8-1" }, "locus": { "chromosome": "28", "start_pos": 35050276, "end_pos": 34989426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099131.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099131.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086666.1" } ] } }, { "isoform_ac": "E1BIP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8/entry#E1BIP9-1", "sequence": { "sequence": "MSLLSAIDTSAASVYQPTQLLNWVYLSLQDTHQASAFDAFRPEPPAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSSSVYKSASPYGSLNNIADGLSSLTEHFSDLTLASETRKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 241, "header": "tr|E1BIP9-1|A0AAA9SRG8_BOVIN Computationally mapped isoform of Zinc finger CCHC-type containing 24 OS=Bos taurus OX=9913 GN=ZCCHC24 PE=4 SV=3 CANONICAL=A0AAA9SRG8-1" }, "locus": { "chromosome": "28", "start_pos": 35050388, "end_pos": 34989426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005060.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005060.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005060.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005060.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616669", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616669", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AZU7-1", "protein_name": "Zinc finger CCHC-type containing 24", "gene_name": "ZCCHC24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPPAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSSSVYKSASPYGSLNNIADGLSSLTEHFSDLTLTSETRKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 241 }, "evidence": [ { "id": "A0AAA9SRG8", "url": "https://omabrowser.org/oma/group/A0AAA9SRG8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZVM8-1", "protein_name": "Zinc finger CCHC-type containing 24", "gene_name": "Zcchc24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSGPSRPPAPRPRSWPSARAARSSWVLPCTPAILTASSSCSAERTGAIAPQGITSSWACPSAKELVQTTCRLVPGCSVLGFVLHQMDSCDPDCRKDAIPGPPQTLSSSVYRNASPYGSLNNIADGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 263 }, "evidence": [ { "id": "A0AAA9SRG8", "url": "https://omabrowser.org/oma/group/A0AAA9SRG8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B2RVL6-1", "protein_name": "Zinc finger CCHC domain-containing protein 24", "gene_name": "Zcchc24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPPAGAAPPELAFGKGRPEQLGSPLHSSYLNSVFQLQRGEALSSSVYRNASPYGSLNNIADGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 241 }, "evidence": [ { "id": "A0AAA9SRG8", "url": "https://omabrowser.org/oma/group/A0AAA9SRG8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N2G6-1", "protein_name": "Zinc finger CCHC domain-containing protein 24", "gene_name": "ZCCHC24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPTAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASPYGSLNNIADGLSSLTEHFSDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 241 }, "evidence": [ { "id": "A0AAA9SRG8", "url": "https://omabrowser.org/oma/group/A0AAA9SRG8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GI53-1", "protein_name": "Zinc finger CCHC-type containing 24", "gene_name": "ZCCHC24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPSSSQHPDLGYTKSPPELGSSLSSSYLNSFFQLQRSEALSSSLYKSASPYGSLNNIVDGLSSLTEHFSDLSLSSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ", "length": 239 }, "evidence": [ { "id": "A0AAA9SRG8", "url": "https://omabrowser.org/oma/group/A0AAA9SRG8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG8" }, { "id": "PS50158", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC-type", "eco_id": "ECO_0000259", "start_pos": 142, "end_pos": 157, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRJ8-1", "uniprot_ac": "A0AAA9SRJ8", "uniprot_id": "A0AAA9SRJ8_BOVIN", "mass": { "chemical_mass": 61322.0, "monoisotopic_mass": 61322.0 }, "refseq": { "ac": "XP_010800893", "name": "glucocorticoid modulatory element-binding protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800893" }, "gene_names": [ { "name": "GMEB1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ] }, { "name": "GMEB1", "type": "synonym", "evidence": [ { "id": "XP_010800893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800893" } ] } ], "protein_names": [ { "name": "Glucocorticoid modulatory element binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8/entry#names_and_taxonomy" } ] }, { "name": "glucocorticoid modulatory element-binding protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010800893", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800893" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GMEB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8", "locus": { "chromosome": "2", "start_pos": 124758267, "end_pos": 124785888, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001160", "url": "https://www.ensembl.org/id/ENSBTAG00000001160" } ] } } ], "crossref": [ { "id": "A0AAA9SRJ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001160", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001160", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540374", "url": "https://www.ncbi.nlm.nih.gov/gene/540374", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SPINQQA", "url": "https://omabrowser.org/oma/group/SPINQQA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIK7", "url": "https://www.orthodb.org/?gene=F1MIK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10417", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10417", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10417:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10417:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01342", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01342", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25892", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25892", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010800893", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIK7", "url": "https://www.uniprot.org/uniprotkb/F1MIK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVETHTIHKIEEGIDASTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRKNQVEQGEEQFLYTLTDLERQLEEQKKQAQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVHQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED", "length": 563, "header": "tr|A0AAA9SRJ8-1|A0AAA9SRJ8_BOVIN Isoform 1 of Glucocorticoid modulatory element binding protein 1 OS=Bos taurus OX=9913 GN=GMEB1 PE=4 SV=1 CANONICAL=A0AAA9SRJ8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8/entry#A0AAA9SRJ8-1", "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVETHTIHKIEEGIDASTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRKNQVEQGEEQFLYTLTDLERQLEEQKKQAQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVHQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED", "length": 563, "header": "tr|A0AAA9SRJ8-1|A0AAA9SRJ8_BOVIN Isoform 1 of Glucocorticoid modulatory element binding protein 1 OS=Bos taurus OX=9913 GN=GMEB1 PE=4 SV=1 CANONICAL=A0AAA9SRJ8-1" }, "locus": { "chromosome": "2", "start_pos": 124785815, "end_pos": 124759271, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087990.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087990.1" } ] } }, { "isoform_ac": "F1MIK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8/entry#F1MIK7-1", "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVETHTIHKIEEGIDASTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDLERQLEEQKKQAQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVHQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED", "length": 522, "header": "tr|F1MIK7-1|A0AAA9SRJ8_BOVIN Computationally mapped isoform of Glucocorticoid modulatory element binding protein 1 OS=Bos taurus OX=9913 GN=GMEB1 PE=4 SV=2 CANONICAL=A0AAA9SRJ8-1" }, "locus": { "chromosome": "2", "start_pos": 124785815, "end_pos": 124759271, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001544.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001544.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001544.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001544.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MX30-1", "protein_name": "Glucocorticoid modulatory element-binding protein 1", "gene_name": "Gmeb1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYDPGSENNAAVVAVETHTIHKIEEGIDTSSIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKDSEEISEDTLMFWKGIADVGLMDEVICNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAQTFGLMDTVKRVLDNRRKQVEQGEGQYLYTLADLERQLEEQKKQAQDPRLKPQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNVPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTTMQDGSTLGNMATMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED", "length": 562 }, "evidence": [ { "id": "A0AAA9SRJ8", "url": "https://omabrowser.org/oma/group/A0AAA9SRJ8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9JL60-1", "protein_name": "Glucocorticoid modulatory element-binding protein 1", "gene_name": "Gmeb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENSAAVVAVETHSIHKIEEGIDASSIEGNEDMEIAYPITCGESKAVLLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKESEEISEDTLMFWKGIADVGLMEEVVCNIQKEMEELLRGVQQRLIQAPFQVTDAAVLNNVANTFGLMDAVKRVLDNRRKQVEQGEEQFLYTLADLERQLEEQKKQAQDPRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSNSPDTVTIHPSSSLALLSSTSMQDGSSLGNMATMVSPMELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDSEADDTEGKAVILETGLRTEEKVVAEMEEHQHQVHNVEIVVLED", "length": 562 }, "evidence": [ { "id": "A0AAA9SRJ8", "url": "https://omabrowser.org/oma/group/A0AAA9SRJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QUZ8-1", "protein_name": "Glucocorticoid modulatory element-binding protein 1", "gene_name": "Gmeb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENSAAVVAVETHTIHKIEEGIDASSIEANEDMEIAYPITCGESKAVLLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKESEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIHAPFQVTDAAVLNNVANTFGLMDTVKRVLDNRRKQVEHGEEQFLYTLADLERQLEEQKKQAQDPRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGTSPVTVHTLPSGPQLFRYATVVSSAKSNSPDTVTIHPSSSLALLSSTSMQDGSTLGNMATMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEADDPEGKAVILETELRTEEKVVANMEERQHQVHNVEIVVLED", "length": 562 }, "evidence": [ { "id": "A0AAA9SRJ8", "url": "https://omabrowser.org/oma/group/A0AAA9SRJ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y692-1", "protein_name": "Glucocorticoid modulatory element-binding protein 1", "gene_name": "GMEB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSENNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED", "length": 573 }, "evidence": [ { "id": "A0AAA9SRJ8", "url": "https://omabrowser.org/oma/group/A0AAA9SRJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" }, { "name": "Hsp27 protein binding", "id": "GO:0051008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRJ8" }, { "id": "PS50864", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50864" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAND", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 156, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 477, "end_pos": 479 }, { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRL8-1", "uniprot_ac": "A0AAA9SRL8", "uniprot_id": "A0AAA9SRL8_BOVIN", "mass": { "chemical_mass": 72785.0, "monoisotopic_mass": 72785.0 }, "refseq": {}, "gene_names": [ { "name": "ABCB10", "type": "recommended", "evidence": [ { "id": "A0AAA9SRL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ] } ], "protein_names": [ { "name": "ATP binding cassette subfamily B member 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SRL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCB10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8", "locus": { "chromosome": "28", "start_pos": 1472462, "end_pos": 1506021, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017053", "url": "https://www.ensembl.org/id/ENSBTAG00000017053" } ] } } ], "crossref": [ { "id": "A0AAA9SRL8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017053", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03249", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03249", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18573", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18573", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BL88", "url": "https://www.orthodb.org/?gene=E1BL88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL88", "url": "https://www.uniprot.org/uniprotkb/E1BL88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL88-1", "url": "https://www.uniprot.org/uniprotkb/E1BL88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGPPAWPLRLLLRRGAAARSPETRTLSTHPAFARPGGVEPALLAGGWAARAPRRWAGGGPGGPAGGAGLARLLALWSRHPGLSRCWALAGPVASRLPRSALPGCSTLVARAAGEAWRRGPALPAAAATPGHDPLLRPAAARRSEAQKLLSLAQPERRRLAAAVGFLAVSSVITMSAPFFLGKIIDVIYTNPSADCSSSLTRLCLALGGVFLCGAAANAVRVYLMQTSGQRIVNRLRASLFSSVLKQEVAFFDKTRTGELINRLSADAALLGRSVTENLSDGLRAGAQASVGIGMMFFVSPKLATFVLSVVPPVSIIAVLYGRYLRKLTKVTQDSLAQATQLAEERIGNIRTVRAFGKEMTEIEKYTSKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGVSIGGLSSFYSELMKGLGAGSRLWELLEREPELPFNEGAVLNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGAGKSTVISLLLRLYDPASGEWFSVLWDRGLSRALLLLSPGRGSECAEAMHCVSSECQRVCSQGGSPLDSGVTFRAVSSPRRPVGHVVLCVHVLISCAVSSAPGAGIRKVPLWGSDGSMWRTCCLHRPSLCRRPGLLEAHHPSHPGPACRQGTWLSVSHSCAAPLMLS", "length": 686, "header": "tr|A0AAA9SRL8-1|A0AAA9SRL8_BOVIN Isoform 1 of ATP binding cassette subfamily B member 10 OS=Bos taurus OX=9913 GN=ABCB10 PE=4 SV=1 CANONICAL=A0AAA9SRL8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8/entry#A0AAA9SRL8-1", "sequence": { "sequence": "MRGPPAWPLRLLLRRGAAARSPETRTLSTHPAFARPGGVEPALLAGGWAARAPRRWAGGGPGGPAGGAGLARLLALWSRHPGLSRCWALAGPVASRLPRSALPGCSTLVARAAGEAWRRGPALPAAAATPGHDPLLRPAAARRSEAQKLLSLAQPERRRLAAAVGFLAVSSVITMSAPFFLGKIIDVIYTNPSADCSSSLTRLCLALGGVFLCGAAANAVRVYLMQTSGQRIVNRLRASLFSSVLKQEVAFFDKTRTGELINRLSADAALLGRSVTENLSDGLRAGAQASVGIGMMFFVSPKLATFVLSVVPPVSIIAVLYGRYLRKLTKVTQDSLAQATQLAEERIGNIRTVRAFGKEMTEIEKYTSKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGVSIGGLSSFYSELMKGLGAGSRLWELLEREPELPFNEGAVLNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGAGKSTVISLLLRLYDPASGEWFSVLWDRGLSRALLLLSPGRGSECAEAMHCVSSECQRVCSQGGSPLDSGVTFRAVSSPRRPVGHVVLCVHVLISCAVSSAPGAGIRKVPLWGSDGSMWRTCCLHRPSLCRRPGLLEAHHPSHPGPACRQGTWLSVSHSCAAPLMLS", "length": 686, "header": "tr|A0AAA9SRL8-1|A0AAA9SRL8_BOVIN Isoform 1 of ATP binding cassette subfamily B member 10 OS=Bos taurus OX=9913 GN=ABCB10 PE=4 SV=1 CANONICAL=A0AAA9SRL8-1" }, "locus": { "chromosome": "28", "start_pos": 1505822, "end_pos": 1483235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132956.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132956.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088012.1" } ] } }, { "isoform_ac": "E1BL88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8/entry#E1BL88-1", "sequence": { "sequence": "MRGPPAWPLRLLLRRGAAARSPETRTLSTHPAFARPGGVEPALLAGGWAARAPRRWAGGGPGGPAGGAGLARLLALWSRHPGLSRCWALAGPVASRLPRSALPGCSTLVARAAGEAWRRGPALPAAAATPGHDPLLRPAAARRSEAQKLLSLAQPERRRLAAAVGFLAVSSVITMSAPFFLGKIIDVIYTNPSADCSSSLTRLCLALGGVFLCGAAANAVRVYLMQTSGQRIVNRLRASLFSSVLKQEVAFFDKTRTGELINRLSADAALLGRSVTENLSDGLRAGAQASVGIGMMLAEERIGNIRTVRAFGKEMTEIEKYTSKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGVSIGGLSSFYSELMKGLGAGSRLWELLEREPELPFNEGAVLNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGAGKSTVISLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADNPASVTAEQIEQAAAVANAAAFIQNFPQGFSTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQQALDRLMEGRTVFIIAHRLSTIKNANVVAVLDQGRIIECGKHEELLLKPDGMYRKLMNKQSFISA", "length": 682, "header": "tr|E1BL88-1|A0AAA9SRL8_BOVIN Computationally mapped isoform of ATP binding cassette subfamily B member 10 OS=Bos taurus OX=9913 GN=ABCB10 PE=4 SV=4 CANONICAL=A0AAA9SRL8-1" }, "locus": { "chromosome": "28", "start_pos": 1505822, "end_pos": 1473466, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022677.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022677.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022677.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022677.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 129, "start_aa": "Thr", "end_pos": 129, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr129", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "ABC-type oligopeptide transporter activity", "id": "GO:0015421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015421", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of erythrocyte differentiation", "id": "GO:0045648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045648", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "positive regulation of hemoglobin biosynthetic process", "id": "GO:0046985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046985", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "erythrocyte development", "id": "GO:0048821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "heme biosynthetic process", "id": "GO:0006783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "mitochondrial unfolded protein response", "id": "GO:0034514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "export from the mitochondrion", "id": "GO:0170037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0170037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" }, { "name": "oligopeptide export from mitochondrion", "id": "GO:0090374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL8" }, { "id": "PS50929", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50929" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transmembrane type-1", "eco_id": "ECO_0000259", "start_pos": 161, "end_pos": 446, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 129 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 278, "end_pos": 280 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRN8-1", "uniprot_ac": "A0AAA9SRN8", "uniprot_id": "A0AAA9SRN8_BOVIN", "mass": { "chemical_mass": 21081.0, "monoisotopic_mass": 21081.0 }, "refseq": {}, "gene_names": [ { "name": "DCTPP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ] } ], "protein_names": [ { "name": "dCTP pyrophosphatase 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.12", "type": "synonym", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8/entry#names_and_taxonomy" } ] }, { "name": "Deoxycytidine-triphosphatase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.", "evidence": [ { "database": "UniProtKB", "id": "F1N4R4", "url": "https://www.uniprot.org/uniprotkb/F1N4R4#function" }, { "database": "UniProtKB", "id": "PIRNR029826", "url": "https://www.uniprot.org/uniprotkb/PIRNR029826#function" }, { "database": "UniProtKB", "id": "ARBA00058235", "url": "https://www.uniprot.org/uniprotkb/ARBA00058235#function" }, { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCTPP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8", "locus": { "chromosome": "25", "start_pos": 26593347, "end_pos": 26599277, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039962", "url": "https://www.ensembl.org/id/ENSBTAG00000039962" } ] } } ], "crossref": [ { "id": "A0AAA9SRN8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11537", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11537", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR025984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N4R4", "url": "https://www.orthodb.org/?gene=F1N4R4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46523:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46523:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "22636", "url": "https://www.rhea-db.org/rhea/22636", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4R4", "url": "https://www.uniprot.org/uniprotkb/F1N4R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4R4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASEEMLGGARGESTTATGPFSFSSEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKPDEEPGPQAWSPRERAALQEELSDVLIYLVALAARCRVDLPQAVLCKMDTNRRRYPVHLSRGSACKYTDLPHGATSENQAMGPADPASESTDSHSRVPFSGCGAIPSGPDIPELLLLSPP", "length": 193, "header": "tr|A0AAA9SRN8-1|A0AAA9SRN8_BOVIN Isoform 1 of dCTP pyrophosphatase 1 OS=Bos taurus OX=9913 GN=DCTPP1 PE=4 SV=1 CANONICAL=A0AAA9SRN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8/entry#A0AAA9SRN8-1", "sequence": { "sequence": "MSASEEMLGGARGESTTATGPFSFSSEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKPDEEPGPQAWSPRERAALQEELSDVLIYLVALAARCRVDLPQAVLCKMDTNRRRYPVHLSRGSACKYTDLPHGATSENQAMGPADPASESTDSHSRVPFSGCGAIPSGPDIPELLLLSPP", "length": 193, "header": "tr|A0AAA9SRN8-1|A0AAA9SRN8_BOVIN Isoform 1 of dCTP pyrophosphatase 1 OS=Bos taurus OX=9913 GN=DCTPP1 PE=4 SV=1 CANONICAL=A0AAA9SRN8-1" }, "locus": { "chromosome": "25", "start_pos": 26599159, "end_pos": 26593447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085640.1" } ] } }, { "isoform_ac": "F1N4R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8/entry#F1N4R4-1", "sequence": { "sequence": "AVLAQPELGRSPLLPPFGRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKPDEEPGPQAWSPRERAALQEELSDVLIYLVALAARCRVDLPQAVLCKMDTNRRRYPVHLSRGSACKYTDLPHGATSENQAMGPADPASESTGQVST", "length": 154, "header": "tr|F1N4R4-1|F1N4R4_BOVIN Computationally mapped isoform of dCTP pyrophosphatase 1 OS=Bos taurus OX=9913 GN=DCTPP1 PE=4 SV=2 CANONICAL=A0AAA9SRN8-1" }, "locus": { "chromosome": "25", "start_pos": 26599057, "end_pos": 26595734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014406.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014406.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014406.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014406.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "dCTP catabolic process", "id": "GO:0006253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006253", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" }, { "name": "DNA protection", "id": "GO:0042262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "pyrimidine deoxyribonucleotide binding", "id": "GO:0032556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" }, { "name": "dCTP diphosphatase activity", "id": "GO:0047840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22636", "name": "", "equation": "dCTP + H2O = dCMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SRN8-1", "Q32KY6-1" ], "evidence": [ { "id": "22636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22636" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SRN8", "gene_name": "DCTPP1", "activity": [ { "ec_number": "3.6.1.12", "activity": "dCTP + H2O = dCMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ] }, { "ec_number": "3.6.1.12", "activity": "", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ] } ] }, { "uniprot_ac": "Q32KY6", "gene_name": "DCTPP1", "activity": [ { "ec_number": "3.6.1.12", "activity": "dCTP + H2O = dCMP + diphosphate + H(+).", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ] }, { "ec_number": "3.6.1.12", "activity": "", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.12", "ec_name": "dCTP + H2O = dCMP + diphosphate + H(+).", "evidence": [ { "id": "3.6.1.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.12" }, { "id": "3.6.1.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRQ0-1", "uniprot_ac": "A0AAA9SRQ0", "uniprot_id": "A0AAA9SRQ0_BOVIN", "mass": { "chemical_mass": 12083.0, "monoisotopic_mass": 12083.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM273", "type": "recommended", "evidence": [ { "id": "A0AAA9SRQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0" } ] } ], "protein_names": [ { "name": "Transmembrane protein 273", "type": "recommended", "evidence": [ { "id": "A0AAA9SRQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM273", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SRQ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "783944", "url": "https://www.ncbi.nlm.nih.gov/gene/783944", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37857", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37857", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37857:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37857:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14986", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14986", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRH0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRH0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRAVVWPERLAVHFIFQVGVSAWRTLGDVGAAQVLATGKPARAEADIKYAVIGTAVGIAISAGFLALKFCMIRKHMFDNDSSDLRSTNVGFNETIALKKRTSRNAHVIEL", "length": 111, "header": "tr|A0AAA9SRQ0-1|A0AAA9SRQ0_BOVIN Isoform 1 of Transmembrane protein 273 OS=Bos taurus OX=9913 GN=TMEM273 PE=4 SV=2 CANONICAL=A0AAA9SRQ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0/entry#A0AAA9SRQ0-1", "sequence": { "sequence": "MPRAVVWPERLAVHFIFQVGVSAWRTLGDVGAAQVLATGKPARAEADIKYAVIGTAVGIAISAGFLALKFCMIRKHMFDNDSSDLRSTNVGFNETIALKKRTSRNAHVIEL", "length": 111, "header": "tr|A0AAA9SRQ0-1|A0AAA9SRQ0_BOVIN Isoform 1 of Transmembrane protein 273 OS=Bos taurus OX=9913 GN=TMEM273 PE=4 SV=2 CANONICAL=A0AAA9SRQ0-1" }, "locus": { "chromosome": "28", "start_pos": 43482024, "end_pos": 43416457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127955.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127955.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086740.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086740.2" } ] } }, { "isoform_ac": "A0ABI0NRH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ0/entry#A0ABI0NRH0-1", "sequence": { "sequence": "MSSAVRMLTVLLLLDVGAAQVLATGKPARAEADIKYAVIGTAVGIAISAGFLALKFCMIRKHMFDNDSSDLRSTNVGFNETIALKKRTSRSFSQSRD", "length": 97, "header": "tr|A0ABI0NRH0-1|A0ABI0NRH0_BOVIN Computationally mapped isoform of Transmembrane protein 273 OS=Bos taurus OX=9913 GN=TMEM273 PE=4 SV=1 CANONICAL=A0AAA9SRQ0-1" }, "locus": { "chromosome": "28", "start_pos": 43445517, "end_pos": 43420954, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145563.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145563.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106306.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 80, "end_pos": 82 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRS2-1", "uniprot_ac": "A0AAA9SRS2", "uniprot_id": "A0AAA9SRS2_BOVIN", "mass": { "chemical_mass": 9880.0, "monoisotopic_mass": 9880.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Immunoglobulin C1-set domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SRS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SRS2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07687", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07687", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF07654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNGTNVACLVKEFYPKDVTISLQSSKKIIEYDPAIAISPGGKYSAVKLGQYGDPDSVTCSVEHNKQTWHSTDFEPKKTIPGRSYLASRG", "length": 90, "header": "tr|A0AAA9SRS2-1|A0AAA9SRS2_BOVIN Isoform 1 of Immunoglobulin C1-set domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SRS2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2/entry#A0AAA9SRS2-1", "sequence": { "sequence": "MKNGTNVACLVKEFYPKDVTISLQSSKKIIEYDPAIAISPGGKYSAVKLGQYGDPDSVTCSVEHNKQTWHSTDFEPKKTIPGRSYLASRG", "length": 90, "header": "tr|A0AAA9SRS2-1|A0AAA9SRS2_BOVIN Isoform 1 of Immunoglobulin C1-set domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SRS2-1" }, "locus": { "chromosome": "10", "start_pos": 22354181, "end_pos": 22353912, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133908.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133908.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085672.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085672.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRS2" }, { "id": "PF07654", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07654" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin C1-set", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 66, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRU0-1", "uniprot_ac": "A0AAA9SRU0", "uniprot_id": "A0AAA9SRU0_BOVIN", "mass": { "chemical_mass": 18898.0, "monoisotopic_mass": 18898.0 }, "refseq": {}, "gene_names": [ { "name": "C18H19orf84", "type": "recommended", "evidence": [ { "id": "A0AAA9SRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0" } ] } ], "protein_names": [ { "name": "Chromosome 19 open reading frame 84", "type": "synonym", "evidence": [ { "id": "A0AAA9SRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C18H19orf84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SRU0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF17703", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17703", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQRKEETGPEGNNLPSPGTGSWPPPSFPALPTSFLGTPDPAHLGLPKSLASVTVPVRLDALSYLLHSALMGAYSLQQSLPSCPCVPQACCTQPGTAKRPPKGRGGWDLPRRPGRGPWGLGRAQQAERGWARGRGAGPKTPPVTPPLPAPPAEDGKKDTQGPEPPVEPPPAEDWEAEYQ", "length": 179, "header": "tr|A0AAA9SRU0-1|A0AAA9SRU0_BOVIN Isoform 1 of Chromosome 19 open reading frame 84 OS=Bos taurus OX=9913 GN=C18H19orf84 PE=4 SV=1 CANONICAL=A0AAA9SRU0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0/entry#A0AAA9SRU0-1", "sequence": { "sequence": "MEQRKEETGPEGNNLPSPGTGSWPPPSFPALPTSFLGTPDPAHLGLPKSLASVTVPVRLDALSYLLHSALMGAYSLQQSLPSCPCVPQACCTQPGTAKRPPKGRGGWDLPRRPGRGPWGLGRAQQAERGWARGRGAGPKTPPVTPPLPAPPAEDGKKDTQGPEPPVEPPPAEDWEAEYQ", "length": 179, "header": "tr|A0AAA9SRU0-1|A0AAA9SRU0_BOVIN Isoform 1 of Chromosome 19 open reading frame 84 OS=Bos taurus OX=9913 GN=C18H19orf84 PE=4 SV=1 CANONICAL=A0AAA9SRU0-1" }, "locus": { "chromosome": "18", "start_pos": 57456217, "end_pos": 57454987, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086673.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086673.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 144, "start_aa": "Thr", "end_pos": 144, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr144", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transposable element silencing by piRNA-mediated DNA methylation", "id": "GO:0141196", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141196", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 144 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRV9-1", "uniprot_ac": "A0AAA9SRV9", "uniprot_id": "A0AAA9SRV9_BOVIN", "mass": { "chemical_mass": 35037.0, "monoisotopic_mass": 35037.0 }, "refseq": {}, "gene_names": [ { "name": "OR4F14I", "type": "recommended", "evidence": [ { "id": "A0AAA9SRV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SRV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4F14I", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SRV9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGANQSVVSEFVLLGLTNSWEIQLLLFVFSSTFYVASMMGNSLIILTVTCDPHLHSPMYFLLANLSFIDLGVSSVTSPKMIYDLFRKHRVISFRGCIAQIFFIHIVGGVEMMLLIAMAFDRYVAICKPLHYLTIMNPRMCISLLVAAWIIGFLHSMVQLPFVVNLPFCGPNVLDSFYCDLPRLIKLACVDTYQLEFMVMANSGFISIGSIFILIISYIVIILTVQKHSSGSSSKALPTLSAHITAVALFFGPLIFIYTWPFPSTHLDKFLAIFYAVLTPFLNPVIYTFRNQEMKVAMRRVCRQLVSYRK", "length": 310, "header": "tr|A0AAA9SRV9-1|A0AAA9SRV9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4F14I PE=3 SV=1 CANONICAL=A0AAA9SRV9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9/entry#A0AAA9SRV9-1", "sequence": { "sequence": "MDGANQSVVSEFVLLGLTNSWEIQLLLFVFSSTFYVASMMGNSLIILTVTCDPHLHSPMYFLLANLSFIDLGVSSVTSPKMIYDLFRKHRVISFRGCIAQIFFIHIVGGVEMMLLIAMAFDRYVAICKPLHYLTIMNPRMCISLLVAAWIIGFLHSMVQLPFVVNLPFCGPNVLDSFYCDLPRLIKLACVDTYQLEFMVMANSGFISIGSIFILIISYIVIILTVQKHSSGSSSKALPTLSAHITAVALFFGPLIFIYTWPFPSTHLDKFLAIFYAVLTPFLNPVIYTFRNQEMKVAMRRVCRQLVSYRK", "length": 310, "header": "tr|A0AAA9SRV9-1|A0AAA9SRV9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4F14I PE=3 SV=1 CANONICAL=A0AAA9SRV9-1" }, "locus": { "chromosome": "10", "start_pos": 28071910, "end_pos": 28070981, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090316.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090316.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085724.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085724.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRV9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS01-1", "uniprot_ac": "A0AAA9SS01", "uniprot_id": "A0AAA9SS01_BOVIN", "mass": { "chemical_mass": 75115.0, "monoisotopic_mass": 75115.0 }, "refseq": {}, "gene_names": [ { "name": "RHPN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SS01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01" } ] } ], "protein_names": [ { "name": "Rhophilin Rho GTPase binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SS01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHPN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01", "locus": { "chromosome": "14", "start_pos": 1260237, "end_pos": 1269411, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002104", "url": "https://www.ensembl.org/id/ENSBTAG00000002104" } ] } } ], "crossref": [ { "id": "A0AAA9SS01", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SS01", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06712", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06712", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618397", "url": "https://www.ncbi.nlm.nih.gov/gene/618397", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23031", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23031", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23031:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23031:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02185", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02185", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SS01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPEDRSDGPGAGEESARLQAAGTVRKGCDLSTDSLHGRLQSRRARIHQQIDRELRMRTGAENLYRATSNARVRETVALELSDVNSSLQLLKEELAGLDSSGDTGQPESEGVTAPMIPLGLKETKPLDWAPPLKELICRHFGEDGASYEAEIRELEDLRQATRTPSRSKAGLELLTAYYNQLCFLEARFVTPARSLGLLFHWYDSLTGLPAQQRALAFEKGSVLFNIGALHTQIGARQNRSCPEGIGRAVEAFQRAAGAFSLLRENFSHAPSPDMSPTSLSMLEQLMRAQAQECVFEGLLLQAPRAAHDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVRGYVPFPWITLVHVKAEHFHALAHYHAALGLCDGASVAESELPVLEKVFLASAEARGPALPQEREERSKLGKAHLRRALLGQEAALQLHAVCRALRREDLLQAVLARALQRSLAKYSELDLEDDFHEATEAPDIQPKTQQRPEGRTPSFSRVKVADIFHRLGPLSVFSAKNHWRLVGPLHLSRGEGGFGFTLRGDSPVLIAAVVPGGRAAVRPPHRRAGKVGPPRGGGVLWDSPRLLQEAGLKEGDYIVSVNGQPCRWWKHAEVVAQLKGVGDEGVSLQVVTLLPAAELPVSGDRRPALGGLLRSQKECGQETPVPSRGSPRPRPLLGWNHKANRGKTGRRLSPAPQP", "length": 687, "header": "tr|A0AAA9SS01-1|A0AAA9SS01_BOVIN Isoform 1 of Rhophilin Rho GTPase binding protein 1 OS=Bos taurus OX=9913 GN=RHPN1 PE=3 SV=1 CANONICAL=A0AAA9SS01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01/entry#A0AAA9SS01-1", "sequence": { "sequence": "MVPEDRSDGPGAGEESARLQAAGTVRKGCDLSTDSLHGRLQSRRARIHQQIDRELRMRTGAENLYRATSNARVRETVALELSDVNSSLQLLKEELAGLDSSGDTGQPESEGVTAPMIPLGLKETKPLDWAPPLKELICRHFGEDGASYEAEIRELEDLRQATRTPSRSKAGLELLTAYYNQLCFLEARFVTPARSLGLLFHWYDSLTGLPAQQRALAFEKGSVLFNIGALHTQIGARQNRSCPEGIGRAVEAFQRAAGAFSLLRENFSHAPSPDMSPTSLSMLEQLMRAQAQECVFEGLLLQAPRAAHDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVRGYVPFPWITLVHVKAEHFHALAHYHAALGLCDGASVAESELPVLEKVFLASAEARGPALPQEREERSKLGKAHLRRALLGQEAALQLHAVCRALRREDLLQAVLARALQRSLAKYSELDLEDDFHEATEAPDIQPKTQQRPEGRTPSFSRVKVADIFHRLGPLSVFSAKNHWRLVGPLHLSRGEGGFGFTLRGDSPVLIAAVVPGGRAAVRPPHRRAGKVGPPRGGGVLWDSPRLLQEAGLKEGDYIVSVNGQPCRWWKHAEVVAQLKGVGDEGVSLQVVTLLPAAELPVSGDRRPALGGLLRSQKECGQETPVPSRGSPRPRPLLGWNHKANRGKTGRRLSPAPQP", "length": 687, "header": "tr|A0AAA9SS01-1|A0AAA9SS01_BOVIN Isoform 1 of Rhophilin Rho GTPase binding protein 1 OS=Bos taurus OX=9913 GN=RHPN1 PE=3 SV=1 CANONICAL=A0AAA9SS01-1" }, "locus": { "chromosome": "14", "start_pos": 1269222, "end_pos": 1260428, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125622.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125622.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086736.1" } ] } }, { "isoform_ac": "A0AAA9SX95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01/entry#A0AAA9SX95-1", "sequence": { "sequence": "MVPEDRSDGPGAGEESARLQAAGTVRKGCDLSTDSLHGRLQSRRARIHQQIDRELRMRTGAENLYRATSNARVRETVALELSDVNSSLQLLKEELAGLDSSGDTGQPESEGVTAPMIPLGLKETKPLDWAPPLKELICRHFGEDGASYEAEIRELEDLRQATRTPSRSKAGLELLTAYYNQLCFLEARFVTPARSLGLLFHWYDSLTGLPAQQRALAFEKGSVLFNIGALHTQIGARQNRSCPEGIGRAVEAFQRAAGAFSLLRENFSHAPSPDMSPTSLSMLEQLMRAQAQECVFEGLLLQAPRAAHDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVRGYVPFPWITLVHVKAEHFHALAHYHAALGLCDGASVAESELPVLEKVFLASAEARGPALPQEREERSKLGKAHLRRALLGQEAALQLHAVCRALRREDLLQAVLARALQRSLAKYSELDLEDDFHEATEAPDIQPKTQQRPEGRTPSFSRVKVADIFHRLGPLSVFSAKNHWRLVGPLHLSRGEGGFGFTLRGDSPVLIAAVVPGGRAAEAGLKEGDYIVSVNGQPCRWWKHAEVVAQLKGVGDEGVSLQVVTLLPAAELPVSGDRRPALGGLLRSQKECGQETPVPSRGSPRPRPLLGWNHKANRGKTGRRLSPAPQP", "length": 659, "header": "tr|A0AAA9SX95-1|A0AAA9SX95_BOVIN Computationally mapped isoform of Rhophilin Rho GTPase binding protein 1 OS=Bos taurus OX=9913 GN=RHPN1 PE=3 SV=1 CANONICAL=A0AAA9SS01-1" }, "locus": { "chromosome": "14", "start_pos": 1269222, "end_pos": 1260428, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106882.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106882.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089964.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089964.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 191, "start_aa": "Thr", "end_pos": 191, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr191", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01" }, { "id": "PS51180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRO1", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 461, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 517, "end_pos": 613, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS01" }, { "id": "PS51860", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51860" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "REM-1", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 104, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 191 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 239, "end_pos": 241 }, { "start_pos": 266, "end_pos": 268 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS09-1", "uniprot_ac": "A0AAA9SS09", "uniprot_id": "A0AAA9SS09_BOVIN", "mass": { "chemical_mass": 67318.0, "monoisotopic_mass": 67318.0 }, "refseq": { "ac": "XP_005210177", "name": "Fanconi anemia group G protein isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210177" }, "gene_names": [ { "name": "FANCG", "type": "recommended", "evidence": [ { "id": "A0AAA9SS09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ] }, { "name": "FANCG", "type": "synonym", "evidence": [ { "id": "XP_005210177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210177" } ] } ], "protein_names": [ { "name": "FA complementation group G", "type": "synonym", "evidence": [ { "id": "A0AAA9SS09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09/entry#names_and_taxonomy" } ] }, { "name": "Fanconi anemia group G protein isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005210177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210177" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FANCG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09", "locus": { "chromosome": "8", "start_pos": 59337760, "end_pos": 59343676, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015005", "url": "https://www.ensembl.org/id/ENSBTAG00000015005" } ] } } ], "crossref": [ { "id": "A0AAA9SS09", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SS09", "database": "AlphaFoldDB", "categories": [] }, { "id": "615352", "url": "https://www.ncbi.nlm.nih.gov/gene/615352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15254:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15254:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28330", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28330", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005210177", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHQTPLGSSASHVSCLDLWREKNDQLVRQAKVAQDSSLPMRRQQLAQDALEGLRGLLCSLRGLPATVSVLPLELTVICNFITLRANLAQGFTEDLAQDIQQGLERVLETQGQLEARLEHGLWGLWDSTLRVSSLLPELLPALHHLAGLQAALWLTTNRLGDLTLLLQTLTVSQSRASEDMLLLLKTWRPPAEESDAPLTLQDARGLRDVLLTAFAYRQGLQELITGSLPKALSSLHEAASGLCPRSLLVQGSPQRALLYLVAALKEGSTWGPPLLEASRLYQQLGNIAAEIESLELLVEALSITRIPEARQLLIEVELLLPQPDPASPLHCGTQSQAKYLLASRCLQTGRAADAAEHYLDLLALLLDGSEPKFSPPPCPPGPCVPELFLEAAAALIQAGRAQDALTVCEELLSRTSFLLPKRPRLWEDARRRTKESPHCSHWVSATHLLQGQAWVQLGAQKEAISEYSRCLELLFRATPKDKEQGPASSCEQGCTSDMALQQLQTAALISRGLEWVALGQDTKALQDFLLSVQMCPGNQDASYHLLQTLRRLDRRDEATALWRRLEAQTELPQENTAWSLPLYLETCLGWIRPPDRETLCEEFQTSGDS", "length": 610, "header": "tr|A0AAA9SS09-1|A0AAA9SS09_BOVIN Isoform 1 of FA complementation group G OS=Bos taurus OX=9913 GN=FANCG PE=4 SV=1 CANONICAL=A0AAA9SS09-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09/entry#A0AAA9SS09-1", "sequence": { "sequence": "MAHQTPLGSSASHVSCLDLWREKNDQLVRQAKVAQDSSLPMRRQQLAQDALEGLRGLLCSLRGLPATVSVLPLELTVICNFITLRANLAQGFTEDLAQDIQQGLERVLETQGQLEARLEHGLWGLWDSTLRVSSLLPELLPALHHLAGLQAALWLTTNRLGDLTLLLQTLTVSQSRASEDMLLLLKTWRPPAEESDAPLTLQDARGLRDVLLTAFAYRQGLQELITGSLPKALSSLHEAASGLCPRSLLVQGSPQRALLYLVAALKEGSTWGPPLLEASRLYQQLGNIAAEIESLELLVEALSITRIPEARQLLIEVELLLPQPDPASPLHCGTQSQAKYLLASRCLQTGRAADAAEHYLDLLALLLDGSEPKFSPPPCPPGPCVPELFLEAAAALIQAGRAQDALTVCEELLSRTSFLLPKRPRLWEDARRRTKESPHCSHWVSATHLLQGQAWVQLGAQKEAISEYSRCLELLFRATPKDKEQGPASSCEQGCTSDMALQQLQTAALISRGLEWVALGQDTKALQDFLLSVQMCPGNQDASYHLLQTLRRLDRRDEATALWRRLEAQTELPQENTAWSLPLYLETCLGWIRPPDRETLCEEFQTSGDS", "length": 610, "header": "tr|A0AAA9SS09-1|A0AAA9SS09_BOVIN Isoform 1 of FA complementation group G OS=Bos taurus OX=9913 GN=FANCG PE=4 SV=1 CANONICAL=A0AAA9SS09-1" }, "locus": { "chromosome": "8", "start_pos": 59343208, "end_pos": 59338030, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132896.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132896.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089171.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS09" }, { "id": "PF28330", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28330" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fanconi anemia group G protein N-terminal", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 199, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS13-1", "uniprot_ac": "A0AAA9SS13", "uniprot_id": "A0AAA9SS13_BOVIN", "mass": { "chemical_mass": 213078.0, "monoisotopic_mass": 213078.0 }, "refseq": {}, "gene_names": [ { "name": "BAZ2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ] } ], "protein_names": [ { "name": "Bromodomain adjacent to zinc finger domain protein 2B", "type": "recommended", "evidence": [ { "id": "A0AAA9SS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BAZ2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13", "locus": { "chromosome": "5", "start_pos": 56831748, "end_pos": 56796775, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017840", "url": "https://www.ensembl.org/id/ENSBTAG00000017840" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017840", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017840", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01397", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01397", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05503", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05503", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15629", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15629", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509799", "url": "https://www.ncbi.nlm.nih.gov/gene/509799", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509799", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509799", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWGNGTQ", "url": "https://omabrowser.org/oma/group/FWGNGTQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N6I8", "url": "https://www.orthodb.org/?gene=F1N6I8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45915", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45915", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45915:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45915:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01429", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01429", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYG4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYG4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6I8", "url": "https://www.uniprot.org/uniprotkb/F1N6I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6I8-1", "url": "https://www.uniprot.org/uniprotkb/F1N6I8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPVGDSGWNPREGLHLFRRGGDYPSAKEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKELTSVVTENGAGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEVSLEPFNTLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSASIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQASDFPPLTQPAPDQSSTIQLHPATSPAVSPTASSAVSLPVSPAASPEISPAISPAAFPEVSPASSAALPPVSSEVSLTASPVTSPKASPAASPAAVFPTVSPADKDISSVPETIADLEDTTVEGVPPSGSGDVLRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHNVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDTRLLKKLEAQETLNEEDKAKMCKIKKKIKQKVQRGECQTTNQGQAKNKRKQETKSLKQKEAKKKSKAEKEKVKTKQEKLKEKVKREKKEKVKMKEKEEVAKTKPTGKADKVLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRIPGLILPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLRAALCDPGLPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDSLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTALAKRTGRPEVELQGPEEGLGRRRSSRIMEETSGMEEEEEEETAAAVHGRRGRRDGEVDITASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLTGIFVEGTEGSLVPEDVIKQETDSLKVATHSTTSPTSFSLKRELAGSSTSASSPARARGRPRKTKPGSMQPRHLKSHSKGQGSEEPQTQLQPETQSHPQLQAHAQPQLQSHPHTHNGFLEPEGSPLSLGQSQHDLSQSAFLSWLSQTQNHGSLLSSSVLTPDSSPGKLDPAPSHAPEEPEPDETEASPDSQAPWFNFSAQMPCNAAPTPPPAVSEDQPTLSPQLPASSKPVSRASAANAYSPGPFSSTPLLGMAHKRQAGDPGETPQSPTGQGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMRSGWWWIRDPETLDATLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSTDPIFEPSQLPAFEEGIVSWTPKEKTYETDLAVLQWVEELEQRVILSDLQIRGWTCPSPDSTREDLAYCEHLADSQEDITWRGRGKEGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPAHEVVLEKALLSTPSSAPQCTPTEISYEITPRVRAWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCLRPKMEAVPEGDWFCAVCLAQQVEGELTQKSGFPKRGQKRKSGYVLTFPEGDNRRRRLLPRGRESPAVPRYSEEGLSPSKRRRVSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL", "length": 1925, "header": "tr|A0AAA9SS13-1|A0AAA9SS13_BOVIN Isoform 1 of Bromodomain adjacent to zinc finger domain protein 2B OS=Bos taurus OX=9913 GN=BAZ2A PE=3 SV=1 CANONICAL=A0AAA9SS13-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13/entry#A0AAA9SS13-1", "sequence": { "sequence": "MTPVGDSGWNPREGLHLFRRGGDYPSAKEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKELTSVVTENGAGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEVSLEPFNTLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSASIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQASDFPPLTQPAPDQSSTIQLHPATSPAVSPTASSAVSLPVSPAASPEISPAISPAAFPEVSPASSAALPPVSSEVSLTASPVTSPKASPAASPAAVFPTVSPADKDISSVPETIADLEDTTVEGVPPSGSGDVLRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHNVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDTRLLKKLEAQETLNEEDKAKMCKIKKKIKQKVQRGECQTTNQGQAKNKRKQETKSLKQKEAKKKSKAEKEKVKTKQEKLKEKVKREKKEKVKMKEKEEVAKTKPTGKADKVLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRIPGLILPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLRAALCDPGLPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDSLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTALAKRTGRPEVELQGPEEGLGRRRSSRIMEETSGMEEEEEEETAAAVHGRRGRRDGEVDITASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLTGIFVEGTEGSLVPEDVIKQETDSLKVATHSTTSPTSFSLKRELAGSSTSASSPARARGRPRKTKPGSMQPRHLKSHSKGQGSEEPQTQLQPETQSHPQLQAHAQPQLQSHPHTHNGFLEPEGSPLSLGQSQHDLSQSAFLSWLSQTQNHGSLLSSSVLTPDSSPGKLDPAPSHAPEEPEPDETEASPDSQAPWFNFSAQMPCNAAPTPPPAVSEDQPTLSPQLPASSKPVSRASAANAYSPGPFSSTPLLGMAHKRQAGDPGETPQSPTGQGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMRSGWWWIRDPETLDATLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSTDPIFEPSQLPAFEEGIVSWTPKEKTYETDLAVLQWVEELEQRVILSDLQIRGWTCPSPDSTREDLAYCEHLADSQEDITWRGRGKEGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPAHEVVLEKALLSTPSSAPQCTPTEISYEITPRVRAWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCLRPKMEAVPEGDWFCAVCLAQQVEGELTQKSGFPKRGQKRKSGYVLTFPEGDNRRRRLLPRGRESPAVPRYSEEGLSPSKRRRVSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL", "length": 1925, "header": "tr|A0AAA9SS13-1|A0AAA9SS13_BOVIN Isoform 1 of Bromodomain adjacent to zinc finger domain protein 2B OS=Bos taurus OX=9913 GN=BAZ2A PE=3 SV=1 CANONICAL=A0AAA9SS13-1" }, "locus": { "chromosome": "5", "start_pos": 56829121, "end_pos": 56802658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116570.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116570.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085800.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085800.1" } ] } }, { "isoform_ac": "A0ABI0NYG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13/entry#A0ABI0NYG4-1", "sequence": { "sequence": "MEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKELTSVVTENGAGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEVSLEPFNTLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSASIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQASDFPPLTQPAPDQSSTIQLHPATSPAVSPTASSAVSLPVSPAASPEISPAISPAAFPEVSPASSAALPPVSSEVSLTASPVTSPKASPAASPAAVFPTVSPADKDISSVPETIADLEDTTVEGVPPSGSGDVLRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHNVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDTRLLKKLEAQETLNEEDKAKMCKIKKKIKQKVQRGECQTTNQGQAKNKRKQETKSLKQKEAKKKSKAEKEKVKTKQEKLKEKVKREKKEKVKMKEKEEVAKTKPTGKADKVLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRIPGLILPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLRAALCDPGLPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDSLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTALAKRTGRPEVELQGPEEGLGRRRSSRIMEETSGMEEEEEEETAAAVHGRRGRRDGEVDITASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLTGIFVEGTEGSLVPEDVIKQETDSLKVATHSTTSPTSFSLKRELAGSSTSASSPARARGRPRKTKPGSMQPRHLKSHSKGQGSEEPQTQLQPETQSHPQLQAHAQPQLQSHPHTHNGFLEPEGSPLSLGQSQHDLSQSAFLSWLSQTQNHGSLLSSSVLTPDSSPGKLDPAPSHAPEEPEPDETEASPDSQAPWFNFSAQMPCNAAPTPPPAVSEDQPTLSPQLPASSKPVSRASAANAYSPGPFSSTPLLGMAHKRQAGDPGETPQSPTGQGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMRSGWWWIRDPETLDATLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSTDPIFEPSQLPAFEEGIVSWTPKEKTYETDLAVLQWVEELEQRVILSDLQIRGWTCPSPDSTREDLAYCEHLADSQEDITWRGRGKEGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPAHEVVLEKALLSTPSSAPQCTPTEISYEITPRVRAWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCLRPKMEAVPEGDWFCAVCLAQQVEGELTQKSGFPKRGQKRKSGYVLTFPEGDNRRRRLLPRGRESPAVPRYSEEGLSPSKRRRVSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL", "length": 1896, "header": "tr|A0ABI0NYG4-1|A0ABI0NYG4_BOVIN Computationally mapped isoform of Bromodomain adjacent to zinc finger domain protein 2B OS=Bos taurus OX=9913 GN=BAZ2A PE=3 SV=1 CANONICAL=A0AAA9SS13-1" }, "locus": { "chromosome": "5", "start_pos": 56829121, "end_pos": 56812629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150556.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150556.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105319.1" } ] } }, { "isoform_ac": "F1N6I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13/entry#F1N6I8-1", "sequence": { "sequence": "MKMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKELTSVVTENGAGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEVSLEPFNTLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSASIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQASDFPPLTQPAPDQSSTIQLHPATSPAVSPTASSAVSLPVSPAASPEISPAISPAAFPEVSPASSAALPPVSSEVSLTASPVTSPKASPAASPAAVFPTVSPADKDISSVPETIADLEDTTVEGVPPSGSGDVLRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHNVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDTRLLKKLEAQETLNEEDKAKMCKIKKKIKQKVQRGECQTTNQGQAKNKRKQETKSLKQKEAKKKSKAEKEKVKTKQEKLKEKVKREKKEKVKMKEKEEVAKTKPTGKADKVLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRIPGLILPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLRAALCDPGLPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDSLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTALAKRTGRPEVELQGPEEGLGRRRSSRIMEETSGMEEEEEEETAAAVHGRRGRRDGEVDITASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLTGIFVEGTEGSLVPEDVIKQETDSLKVATHSTTSPTSFSLKRELAGSSTSASSPARARGRPRKTKPGSMQPRHLKSHSKGQGSEEPQTQLQPETQSHPQLQAHAQPQLQSHPHTHNGFLEPEGSPLSLGQSQHDLSQSAFLSWLSQTQNHGSLLSSSVLTPDSSPGKLDPAPSHAPEEPEPDETEASPDSQAPWFNFSAQMPCNAAPTPPPAVSEDQPTLSPQLPASSKPVSRASAANAYSPGPFSSTPLLGMAHKRQAGDPGETPQSPTGQGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMRSGWWWIRDPETLDATLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSTDPIFEPSQLPAFEEGIVSWTPKEKTYETDLAVLQWVEELEQRVILSDLQIRGWTCPSPDSTREDLAYCEHLADSQEDITWRGRGKEGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPAHEVVLEKALLSTPSSAPQCTPTEISYEITPRVRAWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCLRPKMEAVPEGDWFCAVCLAQQVEGELTQKSGFPKRGQKRKSGYVLTFPEGDNRRRRLLPRGRESPAVPRYSEEGLSPSKRRRVSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL", "length": 1898, "header": "tr|F1N6I8-1|F1N6I8_BOVIN Computationally mapped isoform of Bromodomain adjacent to zinc finger domain protein 2B OS=Bos taurus OX=9913 GN=BAZ2A PE=3 SV=3 CANONICAL=A0AAA9SS13-1" }, "locus": { "chromosome": "5", "start_pos": 56829121, "end_pos": 56796923, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038215.5", "url": "https://www.ensembl.org/id/ENSBTAT00000038215.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038030.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038030.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1358, "start_aa": "Thr", "end_pos": 1358, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1358", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 301, "start_aa": "Thr", "end_pos": 301, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 458, "start_aa": "Thr", "end_pos": 458, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr458", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 526, "start_aa": "Thr", "end_pos": 526, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr526", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509799", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509799", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LBX1-1", "protein_name": "Bromodomain adjacent to zinc finger domain protein 2B", "gene_name": "Baz2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYPKMTLNLGSCLSLSGDITEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGNNLKDPPLLSQYPGGQYPLNGILGGSQQPSSPSHNTNLRAGSQEFWANGTQSPVGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQGVSSDLHPDEAAEKELTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVSSVESLHQEVSVLVPDPTVSCLDDPSHLPEQLEDTPILSEDSLEPFDSLAAEPVSEGLYSIDDTELMGTEDKLPLEDNPVISALDCPALSNANAFSLLAEDSQTSASIFVSPTSPPVLGESVLQDNSFGLNSCSDSEQEEMETQSSNFQRSLTEPAPDQPPSIQLHPAASPTASPVASLAASAEISPAASPVASSPIPPEVFPAVSPASSPALPAISLEASMAAPVTSPPGSPEPSAPAALQTVSTASKDGSSAPGACAGQEEMAGEAVAGSGIGDVLKRHIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGRRGRPRNSEKSKDKDKEVPRVRRGRGRPPKVQVPGLLTETDNRLPKKLETQETLSEEDKAKMTKSKKKVRQKVQRGESQPPVQGQARNKRKQDTKNSKPKDTKRKFKAEKEKMKTKQEKLKEKVKREKKEKVKVKGKEEPRARPSCRATQRRLEERQRQQVILEEMKKPTEDMCLADHQPLPDFTRIPGLTLSSRAFSDCLTIVEFLHSFGKVLGFDLTKDVPSLGVLQEGLLCQGDSLDKVQDLLVRLLKAALHDPGLPSYCQSLKILGEKVSEIPLTRDNVSEVLRCFLMAYRVEPSFCDSLRTQPFQAQPPQQKASVLAFLVHELNGSTIVINEIDKTLENMSSYRKNKWIVEGRLRRLKTALAKRTGRPEVMMEGVDDSLGRRRSSRIMEETSGIEEEEEEENTVAVHGRRGRRDGEVDVAASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRFRRHYWVLPCLAGIFVEGSEGSAVTEDGIKQETESLMEAVTSTPSSAQVSVKREPTGSTTSTSPARSRGRPRKPKPGSLQPQHLKSTIREHDSEQAQSQAHPRAQPQPQPQPQPQPQPQTPIQPHLQSSNGFLEPEGSPFSLGQSQHDLSQSAFLSWLSQTQSHNSLLSSSVLTPDSSPGKLDSAPSQSLEEPEPDETQPCPGPQGPWFNFSAQIPCDAAPTPPPAVSEDQPTPSLQLPASSKPMNTPGAANPCSPVQLSFTHLPGGGPKRLSGDSEEIPQSPTGLGQPKRRGRPPSKFFKQVEQHYLTQLTAQPIPPDMCSGWWWIRDPETLDVLLKALHPRGIREKALHKHLSKHKDFLQEVCLQPLTDPIFEPSQLPALEEGIMSWSPKEKTFETDLAVLQWVEELERRVVLSDLQIRGWTCPSPDSTREDLTYCEHLPDSQEDIPWRGRGREGAVPQRQNTNPLDLAVMRLAVLEQNVERRYLREPLWAAHEVVVEKALLSTPSGEPDSATTEISYEITPRVRVWRQTLERCRSAAQVCLCVGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCAVCLAQQVEEEYTQRPASLKRGQKRKSSFPLTFTEGDSRRRRRRRRMLSRNRESPAVSQYPEDRLSPSKRRRLSMRSHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRVIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL", "length": 1920 }, "evidence": [ { "id": "A0AAA9SS13", "url": "https://omabrowser.org/oma/group/A0AAA9SS13/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91YE5-1", "protein_name": "Bromodomain adjacent to zinc finger domain protein 2A", "gene_name": "Baz2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPGNNLKDPPLLSQFPGGQYPLNGILGGNRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQDVSSDIHPDEAAEKELTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVSSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLEPFDSLAAEPVSGSLYGIDDAELMGAEDKLPLEGNPVISALDCPALSNANAFSLLADDSQTSASIFVSPTSPPVLGESVLQDNSFGLNSCSDSEQEEIETQSSNFQRPLTEPAPDQPPSTQLHPAVSPTASPAASLTASAEISPAVSPVASSPVPPEVFVAVSPASSPALPAISLEASMTTPVTSPQGSPEPSPAAAFQTVSPARKNVSSAPKARADREETTGGAVAVSGSGDVLKRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNNEKAKNKEVPKVKRGRGRPPKIKMPELLNKTDNRLPKKLETQEILSEDDKAKMTKNKKKMRQKVQRGESQTPVQGQARNKRKQDTKSLKQKDTKKKLKAEKEKMKTKQEKLKEKVKREKKEKVKAKGKEGPRARPSCRADKTLATQKRLEEQQRQQAILEEMKKPTEGMCLSDHQPLPDFTRIPGLTLSSRAFSDCLTIVEFLHSFGKVLGFDLTKDVPSLGVLQEGLLCQGDSLDKVQDLLVRLLKAALHDPGLPPYCQSLKILGEKMSEIPLTRDNVSEILRCFLMAYRVEPPFCDSLRTQPFQAQPPQQKAAILAFLVHELNSSTIIINEIDKTLESVSSCRKNKWIVEGRLRRLKTALAKRTGRPEVMMEGAEDGLGRRRSSRIMEETSGIEEEEEEENTTAVHGRRGRKEGEIDVAASSIPELERHIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRHYWVLPYLAGIFVEGSEGSTVTEDEIKQETESLMEVVTSTPSSARASVKRELTGSNASTSPARSRGRPRKPKPGSLQPQHLQSTIRECDSEQAQTQVHPEPQPQLQAPTQPHLQPSSGFLEPEGSPFSLGQSQHDLSQSAFLSWLSQTQSHNSLLSSSVLTPDSSPGKLDSAPSQSLEEPEPDEAQSCPGPQGPWFNFSAQIPCDAAPTPPPAVSEDQPTPSLQLLASSKPMNTPGAANPCSPVQLSSTHLPGGTPKRLSGDSEEMSQSPTGLGQPKRRGRPPSKFFKQVEQHYLTQLTAQPIPPEMCSGWWWIRDPETLDVLLKALHPRGIREKALHKHLSKHKDFLQEVCLQPLTDPIFEPNELPALEEGVMSWSPKEKTYETDLAVLQWVEELEQRVVLSDLQIRGWTCPTPDSTREDLTYCEHLPDSPEDIPWRGRGREGTVPQRQNNNPLDLAVMRLAVLEQNVERRYLREPLWAAHEVVVEKALLSTPNGAPDGTSTEISYEITPRVRVWRQTLERCRSAAQVCLCMGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCAVCLSQQVEEEYTQRPGFPKRGQKRKSSFPLTFPEGDSRRRMLSRSRDSPAVPRYPEDGLSPPKRRRHSMRSHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRVIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHVMRRFFESRWEEFYQGKQANL", "length": 1889 }, "evidence": [ { "id": "A0AAA9SS13", "url": "https://omabrowser.org/oma/group/A0AAA9SS13/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UIF9-1", "protein_name": "Bromodomain adjacent to zinc finger domain protein 2A", "gene_name": "BAZ2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLEPFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEGIMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQEDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL", "length": 1905 }, "evidence": [ { "id": "A0AAA9SS13", "url": "https://omabrowser.org/oma/group/A0AAA9SS13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "pmid": "" }, { "name": "rDNA heterochromatin", "id": "GO:0033553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033553", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1002, "end_pos": 1004, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1346, "end_pos": 1348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 705, "end_pos": 707, "annotation": "n_glycosylation_sequon" }, { "start_pos": 955, "end_pos": 957, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" }, { "id": "PS50014", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bromo", "eco_id": "ECO_0000259", "start_pos": 1830, "end_pos": 1900, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" }, { "id": "PS50827", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50827" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DDT", "eco_id": "ECO_0000259", "start_pos": 867, "end_pos": 932, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" }, { "id": "PS50982", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50982" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MBD", "eco_id": "ECO_0000259", "start_pos": 565, "end_pos": 636, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS13" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 1697, "end_pos": 1747, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 301, 458, 526, 1358 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1002, "end_pos": 1004 }, { "start_pos": 121, "end_pos": 123 }, { "start_pos": 1346, "end_pos": 1348 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 705, "end_pos": 707 }, { "start_pos": 955, "end_pos": 957 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS32-1", "uniprot_ac": "A0AAA9SS32", "uniprot_id": "A0AAA9SS32_BOVIN", "mass": { "chemical_mass": 103451.0, "monoisotopic_mass": 103451.0 }, "refseq": {}, "gene_names": [ { "name": "ESYT2", "type": "recommended", "evidence": [ { "id": "A0AAA9SS32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ] } ], "protein_names": [ { "name": "Extended synaptotagmin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SS32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS).", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M8Q7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8Q7#function" }, { "database": "UniProtKB", "id": "ARBA00058073", "url": "https://www.uniprot.org/uniprotkb/ARBA00058073#function" }, { "database": "UniProtKB", "id": "A0A3Q1ME37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME37#function" }, { "database": "UniProtKB", "id": "F1MN29", "url": "https://www.uniprot.org/uniprotkb/F1MN29#function" }, { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32#function" }, { "database": "UniProtKB", "id": "A0AAA9T8J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8J1#function" }, { "database": "UniProtKB", "id": "A0A3Q1M4B7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4B7#function" }, { "database": "UniProtKB", "id": "A0AAA9U0Z4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ESYT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32", "locus": { "chromosome": "4", "start_pos": 119432152, "end_pos": 119507938, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005483", "url": "https://www.ensembl.org/id/ENSBTAG00000005483" } ] } } ], "crossref": [ { "id": "A0AAA9SS32", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SS32", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005483", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005483", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04050", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04050", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08391", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08391", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21680", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21680", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512582", "url": "https://www.ncbi.nlm.nih.gov/gene/512582", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512582", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512582", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CEAPVFI", "url": "https://omabrowser.org/oma/group/CEAPVFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ME37", "url": "https://www.orthodb.org/?gene=A0A3Q1ME37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45761", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45761", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45761:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45761:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9845576", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9845576", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M4B7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4B7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4B7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8Q7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8Q7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8Q7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN29", "url": "https://www.uniprot.org/uniprotkb/F1MN29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN29-1", "url": "https://www.uniprot.org/uniprotkb/F1MN29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWLHRVRLSRSVKRPWWDSVPWQSAVLGTGCEPVLALPLPQAIFVPLLRRSAPQPLKAEGTDALAQQVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSNPLEFNPDVLKKAAIQKALKSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 929, "header": "tr|A0AAA9SS32-1|A0AAA9SS32_BOVIN Isoform 1 of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4B7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#A0A3Q1M4B7-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSIYEGNFGCGYLKERRASGLVFCENTASVCRALFSNPLEFNPDVLKKAAIQKALKSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 898, "header": "tr|A0A3Q1M4B7-1|A0A3Q1M4B7_BOVIN Computationally mapped isoform of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077212.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077212.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065045.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065045.1" } ] } }, { "isoform_ac": "A0A3Q1M8Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#A0A3Q1M8Q7-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSNPLEFNPDVLKKAAIQKALKSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 814, "header": "tr|A0A3Q1M8Q7-1|A0A3Q1M8Q7_BOVIN Computationally mapped isoform of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069347.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069347.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070314.1" } ] } }, { "isoform_ac": "A0A3Q1ME37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#A0A3Q1ME37-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSIYEGNFGCGYLKERRASGLVFCENTASVCRALFSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 877, "header": "tr|A0A3Q1ME37-1|A0A3Q1ME37_BOVIN Computationally mapped isoform of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067545.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067545.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067126.1" } ] } }, { "isoform_ac": "A0AAA9SS32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#A0AAA9SS32-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWLHRVRLSRSVKRPWWDSVPWQSAVLGTGCEPVLALPLPQAIFVPLLRRSAPQPLKAEGTDALAQQVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSNPLEFNPDVLKKAAIQKALKSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 929, "header": "tr|A0AAA9SS32-1|A0AAA9SS32_BOVIN Isoform 1 of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088659.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088659.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085821.1" } ] } }, { "isoform_ac": "A0AAA9T8J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#A0AAA9T8J1-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWLHRVRLSRSVKRPWWDSVPWQSAVLGTGCEPVLALPLPQAIFVPLLRRSAPQPLKAEGTDALAQQVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 908, "header": "tr|A0AAA9T8J1-1|A0AAA9T8J1_BOVIN Computationally mapped isoform of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092938.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092938.1" } ] } }, { "isoform_ac": "A0AAA9U0Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#A0AAA9U0Z4-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWVHFPDTERAEWLNKTIQSMEFSRPEHWSGEPFPSAGDLPNPGIGPRSPSLQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSNPLEFNPDVLKKAAIQKALKSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 856, "header": "tr|A0AAA9U0Z4-1|A0AAA9U0Z4_BOVIN Computationally mapped isoform of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=1 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088328.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088328.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103378.1" } ] } }, { "isoform_ac": "F1MN29-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32/entry#F1MN29-1", "sequence": { "sequence": "MSGSRAPGPEVGASGAEPPGAALSVDVAGLLAQLARSFALLLPVYALGYLGLSFSWVLLALGLLVWCRRSRGLKATRLCRALALLEDEERAVRLGVRACDLPAWVHFPDTERAEWLNKTIQSMEFSRPEHWSGEPFPSAGDLPNPGIGPRSPSLQFIEKLFRETIEPAVRGAHTHLSTFSFTRVDLGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVQSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGVIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPRGKLHLKLEWLTLMPDASNLEQVLTDIRADKDQANDGLSSSLLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQELEVEVRDEQHQCSLGNLRIPLSQLLAREDMTLNQRFQLSNSGPNSSLKMKLALRVLHLEKQERPPDHQHSAQVKRPSVSKEGRKVSVRPQMSASPGSGDGGTAPSTPVAGGDERPGVEERGLPVEAGLQGPRDLGRSSSSLQAGPTGSPSHVSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLVVVVHSCRNLIAFSEDGSDPYVRLYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPDVQRRTLDVAVKNSGGFLSKDKGLLGKVLVGLASEELAKGWTQWYDLTEDGTRPHVVT", "length": 869, "header": "tr|F1MN29-1|F1MN29_BOVIN Computationally mapped isoform of Extended synaptotagmin-2 OS=Bos taurus OX=9913 GN=ESYT2 PE=1 SV=4 CANONICAL=A0AAA9SS32-1" }, "locus": { "chromosome": "4", "start_pos": 119507739, "end_pos": 119432689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043608.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043608.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041167.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041167.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 749, "start_aa": "Thr", "end_pos": 749, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr749", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 761, "start_aa": "Thr", "end_pos": 761, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr761", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512582", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512582", "resource": "KEGG Pathway" }, { "id": "R-BTA-9845576", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9845576", "resource": "Reactome", "description": "Glycosphingolipid transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0B4K6F9-1", "protein_name": "Extended synaptotagmin-like protein 2, isoform C", "gene_name": "Esyt2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDNSPSVPLAEFTIPPDPTETEPFVPLVEVKKMNESPVVTPTTPTGNGTPPTQTTNGNSIVATKSVSDDNSIFSVFYTLGKKVAIVGSIYLVGYMGWSVAWLIAPVILSVARDQLAKTSEKKRDIAKASALASEKDVILARIDELPAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINFYLGGMKGGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLGKGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHVRLQWYKLTADPNDLQQILLETQLLRVTSMSSAVLSVFIDSARHLKQARSSSKPDPYLVCSVNKQKQQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQPFQLQKSGPESKLYMSLSLRILKPGEIDKDSDALEQVAALTRSSSVKTPDVAAVSPPAFKESQASSKRLSAESPISEEDPVAATKISPAMSASTSSEKPISELATSVLTHRFPDSTSSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQKIPLRDPSNIPDPYVKLYLLPGRTKESKRKTSVIKDNCNPVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDLQPEIRHE", "length": 853 }, "evidence": [ { "id": "A0AAA9SS32", "url": "https://omabrowser.org/oma/group/A0AAA9SS32/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A0A1D5P2W2-1", "protein_name": "Extended synaptotagmin 2", "gene_name": "ESYT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGAAEKQSPGAGTPAAAEKAAAGGDAGPEPPPPSMLSVDVTGLVSQFARSFVLIFPVYVLGYLGLSFSWVLIALCGLFWIRRHRGGKTSRLGRALAFLEDEEEAVRLSVSSADLPAWVHFPDTERAEWLNKTVKQMWPFICQFIEKLFRETIEPAVRGANNHLSTFSFTKIDIGHQPLRINGVKVYTENVDKRQIILDLQISFAGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLIGALSLFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLEGKDTYLKGIVKGKSDPYGIIRVGNQIFQSKVIKENLNPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVSKGKLHLKLEWLTLMPTAENLDKVLTSIRADKDQANDGLSSALLILYLDSARNLPHNPLEFNPDALKKSAVQKALKSGKKLNSNPNPLVLLSVGHKAQESKIRYKTNEPVWEENFTFFVHNPKRQDLEVEVRDEQHQCSLGNFKLPLSQLLESEDLTMHQRFQLSNSGPNSTINMKIALRVLSLEKQARSPDHQHSAQVKRPSVSKDARKSSFKPQVPVSPPLDSSKHAPASPVADSDKKTDVAEKSQPPNASPQWPTDLSRSSSSLHASNFNYSPSHLSVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAFSEEGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQIFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLIPLTSEELAKGWTQWYDLTEDGTRPHGAS", "length": 879 }, "evidence": [ { "id": "A0AAA9SS32", "url": "https://omabrowser.org/oma/group/A0AAA9SS32/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0FGR8-1", "protein_name": "Extended synaptotagmin-2", "gene_name": "ESYT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT", "length": 921 }, "evidence": [ { "id": "A0AAA9SS32", "url": "https://omabrowser.org/oma/group/A0AAA9SS32/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZJ32-1", "protein_name": "Extended synaptotagmin-2", "gene_name": "Esyt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSAGGEGPEAGTGRAGGRSEPEAPGSALSVDLPGLLGQLARSFALLLPVYALGYLGLSFSWVLLALGLLAWCRRSRGLKASRLCRALALLEDEEQAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANAHLSTFSFTKVDVGHQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSKVVKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLKLEWLTLMPDAANLDKVLADIRADKDQANDGLSSALLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTSEPVWEENFTFFIHNPKRQDLEVEVKDEQHQCSLGSLRIPLSQLLASDNMTINQRFQLSNSGPNSTLKMKIALRVLHLEKQERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSASPGTGGTNTAPSTPVMGVDDKPAMEEKPQPPEASPLGQRDLGRSSSSLLASPSHIAAKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQVIT", "length": 845 }, "evidence": [ { "id": "A0AAA9SS32", "url": "https://omabrowser.org/oma/group/A0AAA9SS32/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3TZZ7-1", "protein_name": "Extended synaptotagmin-2", "gene_name": "Esyt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSAGGEGPEAGPGRAGGRSEPEAPGSALSVDLPGLLGQLARSFALLLPVYALGYLGLSFSWVLLALGLLAWCRRSRGLKASRLCRALALLEDEEQAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANAHLSTFSFTKVDVGQQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLKLEWLTLMPDAANLDKVLADIRADKDQASDGLSSALLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTSEPVWEENFTFFIHNPRRQDLEVEVKDEQHQCSLGSLRIPLSQLLTSDNMTINQRFQLSNSGPNSTLKMKIALRVLHLEKQERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSASPGTGGANTAPSTPVMGVDDKPAMEEKPQPPEASPLGHRDLGRSSSSLLASPSHIAAKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVVLASEELAKGWTQWYDLTEDGTRPQVIT", "length": 845 }, "evidence": [ { "id": "A0AAA9SS32", "url": "https://omabrowser.org/oma/group/A0AAA9SS32/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "endoplasmic reticulum-plasma membrane tethering", "id": "GO:0061817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "phosphatidylethanolamine binding", "id": "GO:0008429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "phosphatidylcholine binding", "id": "GO:0031210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 647, "end_pos": 649, "annotation": "n_glycosylation_sequon" }, { "start_pos": 786, "end_pos": 788, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 352, "end_pos": 472, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS32" }, { "id": "PS51847", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51847" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SMP-LTD", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 353, "start_aa": "Asp", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 749, 761 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 182, "end_pos": 184 }, { "start_pos": 313, "end_pos": 315 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 591, "end_pos": 593 }, { "start_pos": 647, "end_pos": 649 }, { "start_pos": 786, "end_pos": 788 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS33-1", "uniprot_ac": "A0AAA9SS33", "uniprot_id": "A0AAA9SS33_BOVIN", "mass": { "chemical_mass": 22805.0, "monoisotopic_mass": 22805.0 }, "refseq": { "ac": "XP_010820136", "name": "polyadenylate-binding protein 1-like 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820136" }, "gene_names": [ { "name": "LOC784438", "type": "recommended", "evidence": [ { "id": "A0AAA9SS33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33" } ] }, { "name": "LOC784438", "type": "synonym", "evidence": [ { "id": "XP_010820136", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820136" } ] } ], "protein_names": [ { "name": "RRM domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SS33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33/entry#names_and_taxonomy" } ] }, { "name": "polyadenylate-binding protein 1-like 2", "type": "synonym", "evidence": [ { "id": "XP_010820136", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820136" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC784438", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33", "locus": {} } ], "crossref": [ { "id": "cd12378", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12378", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12379", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12379", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784438", "url": "https://www.ncbi.nlm.nih.gov/gene/784438", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784438", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784438", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010820136", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010820136", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SS33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLYVGDLHPEVTEAMLYEKFSPAGPILSIRLCRDKITRRSLGYAYVNYQQPVDAKRALETLNFDVIKGRPVRIMWSQRDPSLRKSGVGNVFIKNLGKTIDNKALYNIFSAFGNILSCKVACDEKGPKGYGFVHFQKQESAERAIDAMNGMFLNYRKIFVGRFKSHKEREAERGAWARQSTSADVKDFEEDTDEEATFR", "length": 200, "header": "tr|A0AAA9SS33-1|A0AAA9SS33_BOVIN Isoform 1 of RRM domain-containing protein OS=Bos taurus OX=9913 GN=LOC784438 PE=4 SV=1 CANONICAL=A0AAA9SS33-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33/entry#A0AAA9SS33-1", "sequence": { "sequence": "MASLYVGDLHPEVTEAMLYEKFSPAGPILSIRLCRDKITRRSLGYAYVNYQQPVDAKRALETLNFDVIKGRPVRIMWSQRDPSLRKSGVGNVFIKNLGKTIDNKALYNIFSAFGNILSCKVACDEKGPKGYGFVHFQKQESAERAIDAMNGMFLNYRKIFVGRFKSHKEREAERGAWARQSTSADVKDFEEDTDEEATFR", "length": 200, "header": "tr|A0AAA9SS33-1|A0AAA9SS33_BOVIN Isoform 1 of RRM domain-containing protein OS=Bos taurus OX=9913 GN=LOC784438 PE=4 SV=1 CANONICAL=A0AAA9SS33-1" }, "locus": { "chromosome": "X", "start_pos": 77833520, "end_pos": 77832921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120866.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120866.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084910.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784438", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784438", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS33" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 80, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ16-1", "uniprot_ac": "A0AAA9SQ16", "uniprot_id": "A0AAA9SQ16_BOVIN", "mass": { "chemical_mass": 35399.0, "monoisotopic_mass": 35399.0 }, "refseq": {}, "gene_names": [ { "name": "GPR35", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 35", "type": "synonym", "evidence": [ { "id": "A0AAA9SQ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16", "locus": { "chromosome": "3", "start_pos": 120017724, "end_pos": 119987157, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030193", "url": "https://www.ensembl.org/id/ENSBTAG00000030193" } ] } } ], "crossref": [ { "id": "A0AAA9SQ16", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030193", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030193", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15164", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15164", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505056", "url": "https://www.ncbi.nlm.nih.gov/gene/505056", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505056", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505056", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N600", "url": "https://www.orthodb.org/?gene=F1N600", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24232:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24232:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373076", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZ92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N600", "url": "https://www.uniprot.org/uniprotkb/F1N600", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N600-1", "url": "https://www.uniprot.org/uniprotkb/F1N600-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFGRTCRGVSSSGGNQRVSPGIMNSSNCSSWDANPVYYTYMGGLLALGLLLNGLALWVLCWRLPRWTETRIYMANLAVADLCLLCALPSFLYFQKQTSKDTPLCQISQAVYLLNRYMSISLVTAIAVDRYVAVRHPLRARRLRSPGRAAAVCTALWAVVLGSLVLRWFLDVQDGGFCFAVRSGRSTYTGVFSLLGFYLPLAVLVFCSLQVVTALTQRPEANPGQAEATQKASRMVLANLAVFVVCFLPFHMVLTMRVALGLQTCAIKVAMQITSRLSDANCCLDAICYYFMAKEFQEASVSTTSPRAKAHKSKDSVTMTLT", "length": 322, "header": "tr|A0AAA9SQ16-1|A0AAA9SQ16_BOVIN Isoform 1 of G protein-coupled receptor 35 OS=Bos taurus OX=9913 GN=GPR35 PE=3 SV=1 CANONICAL=A0AAA9SQ16-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZ92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16/entry#A0AAA9RZ92-1", "sequence": { "sequence": "MNSSNCSSWDANPVYYTYMGGLLALGLLLNGLALWVLCWRLPRWTETRIYMANLAVADLCLLCALPSFLYFQKQTSKDTPLCQISQAVYLLNRYMSISLVTAIAVDRYVAVRHPLRARRLRSPGRAAAVCTALWAVVLGSLVLRWFLDVQDGGFCFAVRSGRSTYTGVFSLLGFYLPLAVLVFCSLQVVTALTQRPEANPGQAEATQKASRMVLANLAVFVVCFLPFHMVLTMRVALGLQTCAIKVAMQITSRLSDANCCLDAICYYFMAKEFQEASVSTTSPRAKAHKSKDSVTMTLT", "length": 299, "header": "tr|A0AAA9RZ92-1|A0AAA9SQ16_BOVIN Computationally mapped isoform of G protein-coupled receptor 35 OS=Bos taurus OX=9913 GN=GPR35 PE=3 SV=1 CANONICAL=A0AAA9SQ16-1" }, "locus": { "chromosome": "3", "start_pos": 120013899, "end_pos": 120013003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087732.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087732.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084690.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084690.1" } ] } }, { "isoform_ac": "A0AAA9SQ16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16/entry#A0AAA9SQ16-1", "sequence": { "sequence": "MPFGRTCRGVSSSGGNQRVSPGIMNSSNCSSWDANPVYYTYMGGLLALGLLLNGLALWVLCWRLPRWTETRIYMANLAVADLCLLCALPSFLYFQKQTSKDTPLCQISQAVYLLNRYMSISLVTAIAVDRYVAVRHPLRARRLRSPGRAAAVCTALWAVVLGSLVLRWFLDVQDGGFCFAVRSGRSTYTGVFSLLGFYLPLAVLVFCSLQVVTALTQRPEANPGQAEATQKASRMVLANLAVFVVCFLPFHMVLTMRVALGLQTCAIKVAMQITSRLSDANCCLDAICYYFMAKEFQEASVSTTSPRAKAHKSKDSVTMTLT", "length": 322, "header": "tr|A0AAA9SQ16-1|A0AAA9SQ16_BOVIN Isoform 1 of G protein-coupled receptor 35 OS=Bos taurus OX=9913 GN=GPR35 PE=3 SV=1 CANONICAL=A0AAA9SQ16-1" }, "locus": { "chromosome": "3", "start_pos": 120013899, "end_pos": 120006690, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122027.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122027.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086033.1" } ] } }, { "isoform_ac": "A0AAA9T1J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16/entry#A0AAA9T1J1-1", "sequence": { "sequence": "MESPRQPWSGLAQAVGSPMGCHCHQPAHCLPALRVRSGRCRDPAHPAPLPHQPFGRTCRGVSSSGGNQRVSPGIMNSSNCSSWDANPVYYTYMGGLLALGLLLNGLALWVLCWRLPRWTETRIYMANLAVADLCLLCALPSFLYFQKQTSKDTPLCQISQAVYLLNRYMSISLVTAIAVDRYVAVRHPLRARRLRSPGRAAAVCTALWAVVLGSLVLRWFLDVQDGGFCFAVRSGRSTYTGVFSLLGFYLPLAVLVFCSLQVVTALTQRPEANPGQAEATQKASRMVLANLAVFVVCFLPFHMVLTMRVALGLQTCAIKVAMQITSRLSDANCCLDAICYYFMAKEFQEASVSTTSPRAKAHKSKDSVTMTLT", "length": 373, "header": "tr|A0AAA9T1J1-1|A0AAA9T1J1_BOVIN Computationally mapped isoform of G protein-coupled receptor 35 OS=Bos taurus OX=9913 GN=GPR35 PE=3 SV=1 CANONICAL=A0AAA9SQ16-1" }, "locus": { "chromosome": "3", "start_pos": 120013899, "end_pos": 120006690, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116540.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116540.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092648.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092648.1" } ] } }, { "isoform_ac": "F1N600-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16/entry#F1N600-1", "sequence": { "sequence": "MAGTPLPPQVRRLGVAVVEERGPGGSAVPRAKHGDGDGGPGHTQQPPRERPRLPGTSLEEVHLDRAGMPTSCSIASTIFSQTPTIPRGEGPRPQGRRSPCLQSRIWTPTRHRLPHRLLGRCEAGEESPRQPWSGLAQAVGSPMGCHCHQPAHCLPALRVRSGRCRDPAHPAPLPHQPFGRTCRGVSSSGGNQRVSPGIMNSSNCSSWDANPVYYTYMGGLLALGLLLNGLALWVLCWRLPRWTETRIYMANLAVADLCLLCALPSFLYFQKQTSKDTPLCQISQAVYLLNRYMSISLVTAIAVDRYVAVRHPLRARRLRSPGRAAAVCTALWAVVLGSLVLRWFLDVQDGGFCFAVRSGRSTYTGVFSLLGFYLPLAVLVFCSLQVVTALTQRPEANPGQAEATQKASRMVLANLAVFVVCFLPFHMVLTMRVALGLQTCAIKVAMQITSRLSDANCCLDAICYYFMAKEFQEASVSTTSPRAKAHKSKDSVTMTLT", "length": 497, "header": "tr|F1N600-1|F1N600_BOVIN Computationally mapped isoform of G protein-coupled receptor 35 OS=Bos taurus OX=9913 GN=GPR35 PE=3 SV=4 CANONICAL=A0AAA9SQ16-1" }, "locus": { "chromosome": "3", "start_pos": 120013899, "end_pos": 120006040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021281.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021281.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021281.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021281.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505056", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505056", "resource": "KEGG Pathway" }, { "id": "R-BTA-373076", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "resource": "Reactome", "description": "Class A/1 (Rhodopsin-like receptors)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" } ], "pmid": "" }, { "name": "chemokine receptor activity", "id": "GO:0004950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004950", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ16" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 289, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 25, "end_pos": 27 }, { "start_pos": 28, "end_pos": 30 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRE5-1", "uniprot_ac": "A0AAA9SRE5", "uniprot_id": "A0AAA9SRE5_BOVIN", "mass": { "chemical_mass": 65965.0, "monoisotopic_mass": 65965.0 }, "refseq": { "ac": "XP_059732509", "name": "zinc finger imprinted 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732509" }, "gene_names": [ { "name": "ZIM2", "type": "recommended", "evidence": [ { "id": "A0AAA9SRE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ] }, { "name": "ZIM2", "type": "synonym", "evidence": [ { "id": "XP_059732509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732509" } ] } ], "protein_names": [ { "name": "Zinc finger imprinted 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SRE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5/entry#names_and_taxonomy" } ] }, { "name": "zinc finger imprinted 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059732509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732509" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZIM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5", "locus": { "chromosome": "18", "start_pos": 64006073, "end_pos": 64022507, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011664", "url": "https://www.ensembl.org/id/ENSBTAG00000011664" } ] } } ], "crossref": [ { "id": "A0AAA9SRE5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "444865", "url": "https://www.ncbi.nlm.nih.gov/gene/444865", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF455", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF455", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059732509", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732509", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHMKEVLDDILRNPQLIHLHDQEENPETTPIRNPEVLRVSHQNFRYFQSLSVTGPHQAVSQIQELCWRWLQPEIHTKEQIMEQLVLEQFLNILPEKVQIWVRSKQPKSSKEAGDLVADLIQVCEEEGFSLQNFVLAEKRNTNEHQKEDTEMSDSKPFVTSQCSCQGSQVKMPTETAEELVTFEDVAVHFSPEELPYLSASQRNLYREVMLENYRNLVSLGYQFPKPDIISQLEEEESHAREEDGSTVTCQDWEEQSETKDLTPEQSLPVEKSSSGAGIEDLEAGDSWYTHTGESSDDPLESQQVKPAEVLSPTEMSDPKTLNQEGSHEGDQLEKSLELNKPSESLPGKDPQEHTTPEVCTRSQLAHNLFFLQENKHYRCEFFDRNFSTRPGREKHQQIHTGKKPFVCKQCGEAFYLMLHLTRHQKTHSDGKSLTQRADVYGRVRIQSQDYHECFQCGKAFIQAVHLFQHLKAHEVAMALPLELPRNKMYLIRYKRQHDYIGERAYQCCDCGRRFRQSSHLIQHYRIHAQERPYQCQLCGKCFSQPSYLTQHYQLHSQEKPLECRHC", "length": 567, "header": "tr|A0AAA9SRE5-1|A0AAA9SRE5_BOVIN Isoform 1 of Zinc finger imprinted 2 OS=Bos taurus OX=9913 GN=ZIM2 PE=3 SV=1 CANONICAL=A0AAA9SRE5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5/entry#A0AAA9SRE5-1", "sequence": { "sequence": "MLHMKEVLDDILRNPQLIHLHDQEENPETTPIRNPEVLRVSHQNFRYFQSLSVTGPHQAVSQIQELCWRWLQPEIHTKEQIMEQLVLEQFLNILPEKVQIWVRSKQPKSSKEAGDLVADLIQVCEEEGFSLQNFVLAEKRNTNEHQKEDTEMSDSKPFVTSQCSCQGSQVKMPTETAEELVTFEDVAVHFSPEELPYLSASQRNLYREVMLENYRNLVSLGYQFPKPDIISQLEEEESHAREEDGSTVTCQDWEEQSETKDLTPEQSLPVEKSSSGAGIEDLEAGDSWYTHTGESSDDPLESQQVKPAEVLSPTEMSDPKTLNQEGSHEGDQLEKSLELNKPSESLPGKDPQEHTTPEVCTRSQLAHNLFFLQENKHYRCEFFDRNFSTRPGREKHQQIHTGKKPFVCKQCGEAFYLMLHLTRHQKTHSDGKSLTQRADVYGRVRIQSQDYHECFQCGKAFIQAVHLFQHLKAHEVAMALPLELPRNKMYLIRYKRQHDYIGERAYQCCDCGRRFRQSSHLIQHYRIHAQERPYQCQLCGKCFSQPSYLTQHYQLHSQEKPLECRHC", "length": 567, "header": "tr|A0AAA9SRE5-1|A0AAA9SRE5_BOVIN Isoform 1 of Zinc finger imprinted 2 OS=Bos taurus OX=9913 GN=ZIM2 PE=3 SV=1 CANONICAL=A0AAA9SRE5-1" }, "locus": { "chromosome": "18", "start_pos": 64019858, "end_pos": 64011121, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129961.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129961.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086549.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086549.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 378, "end_pos": 405, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SRE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 181, "end_pos": 252, "start_aa": "Val", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SRE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRE5" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 120, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 386, "end_pos": 388 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRU9-1", "uniprot_ac": "A0AAA9SRU9", "uniprot_id": "A0AAA9SRU9_BOVIN", "mass": { "chemical_mass": 171230.0, "monoisotopic_mass": 171230.0 }, "refseq": { "ac": "XP_005216882", "name": "protein dispatched homolog 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216882" }, "gene_names": [ { "name": "DISP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9" } ] }, { "name": "DISP1", "type": "synonym", "evidence": [ { "id": "XP_005216882", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216882" } ] } ], "protein_names": [ { "name": "Protein dispatched homolog 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SRU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9/entry#names_and_taxonomy" } ] }, { "name": "protein dispatched homolog 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005216882", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216882" } ] } ], "function": [ { "annotation": "Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY8#function" }, { "database": "UniProtKB", "id": "ARBA00060153", "url": "https://www.uniprot.org/uniprotkb/ARBA00060153#function" }, { "database": "UniProtKB", "id": "A0A3Q1MC08", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC08#function" }, { "database": "UniProtKB", "id": "A0AAA9SRU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9#function" }, { "database": "UniProtKB", "id": "A0ABI0NMI7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMI7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DISP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9", "locus": { "chromosome": "16", "start_pos": 26519281, "end_pos": 26451774, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049277", "url": "https://www.ensembl.org/id/ENSBTAG00000049277" } ] } } ], "crossref": [ { "id": "A0AAA9SRU9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049277", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049277", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534637", "url": "https://www.ncbi.nlm.nih.gov/gene/534637", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTY8", "url": "https://www.orthodb.org/?gene=A0A3Q1LTY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC08", "url": "https://www.orthodb.org/?gene=A0A3Q1MC08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45951", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45951", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45951:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45951:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12349", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12349", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005216882", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216882", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTY8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTY8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC08", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC08-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NMI7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NMI7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMSNGNSDFMVLSNGSIAARATTPTPLSPCDGDPAAQQLACKEAPRTKVSPNGCLQVNGTVKSSFLPLDNQRTPPVLPQCCHPCPYHHPLTPHDSHQECHPEAGPAAPPALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQHVPQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTVFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSAGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLEPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMAPKTADYTPALKYSMLFSPTEKGESMMNIYLDNFENWNASDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAMVIVLLVMCIYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSAFNIASPASQVWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISNELSSAPEGLSHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDADREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSASPGDKGPSKTHTLNAYHLDPRGQTSEMEHEFYELEPLAAHSCTASEKTTYEETHICSEFFSSQARHLGLPVHAAYNSELNKSTKNETSPALLQASLEQHTMCHFFSLNQRCSCPNAYKHLKYGPPSCQQMGDCLCRQCAPTAGSFVHVQNSLAPLKAAHQAPEGFVHPAPHIHPCPGLQCRAKPPGAQNALPRSFFLHPVQHIQAQEKITKTSVHSLQSLEEHLPKTVEPSSLVCRSTGALHKACCGPETHPRGLCKNRDLGTTEGSGGATAKDSVSVSQTNKAERQVEPSPSQTDVIVSSEHLNQNEPKFLFNHLIGEAGYRSCPNNPQSCGRIVRVKCSSVDCQIPNIEANVPAVLTPSELSGESLLIKTL", "length": 1532, "header": "tr|A0AAA9SRU9-1|A0AAA9SRU9_BOVIN Isoform 1 of Protein dispatched homolog 1 OS=Bos taurus OX=9913 GN=DISP1 PE=3 SV=2 CANONICAL=A0AAA9SRU9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9/entry#A0A3Q1LTY8-1", "sequence": { "sequence": "MLCQKGSGNWSMAMSNGNSDFMVLSNGSIAARATTPTPLSPCDGDPAAQQLACKEAPRTKVSPNGCLQVNGTVKSSFLPLDNQRTPPVLPQCCHPCPYHHPLTPHDSHQECHPEAGPAAPPALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQHVPQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTVFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSAGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLEPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMAPKTADYTPALKYSMLFSPTEKGESMMNIYLDNFENWNASDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAMVIVLLVMCIYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSAFNIASPASQVWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISNELSSAPEGLSHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDADREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSASPGDKGPSKTHTLNAYHLDPRGQTSEMEHEFYELEPLAAHSCTASEKTTYEETHICSEFFSSQARHLGLPVHAAYNSELNKSTKNETSPALLQASLEQHTMCHFFSLNQRCSCPNAYKHLKYGPPSCQQMGDCLCRQCAPTAGSFVHVQNSLAPLKAAHQAPEGFVHPAPHIHPCPGLQCRAKPPGAQNALPRSFFLHPVQHIQAQEKITKTSVHSLQSLEEHLPKTVEPSSLVCRSTGALHKACCGPETHPRGLCKNRDLGTTEGSGGATAKDSVSVSQTNKAERQVEPSPSQTDVIVSSEHLNQNEPKFLFNHLIGEAGYRSCPNNPQSCGRIVRVKCSSVDCQIPNIEANVPAVLTPSELSGESLLIKTL", "length": 1543, "header": "tr|A0A3Q1LTY8-1|A0A3Q1LTY8_BOVIN Computationally mapped isoform of Protein dispatched homolog 1 OS=Bos taurus OX=9913 GN=DISP1 PE=3 SV=2 CANONICAL=A0AAA9SRU9-1" }, "locus": { "chromosome": "16", "start_pos": 26518277, "end_pos": 26457104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072510.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072510.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063957.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063957.2" } ] } }, { "isoform_ac": "A0A3Q1MC08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9/entry#A0A3Q1MC08-1", "sequence": { "sequence": "MGFSRQEYWSGLPCPSSGDQIRISHVSCIGRPSRPFKLPKSYAALIADWPVVVLGMCTVFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSAGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLEPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMAPKTADYTPALKYSMLFSPTEKGESMMNIYLDNFENWNASDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAMVIVLLVMCIYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSAFNIASPASQVWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISNELSSAPEGLSHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDADREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSASPGDKGPSKTHTLNAYHLDPRGQTSEMEHEFYELEPLAAHSCTASEKTTYEETHICSEFFSSQARHLGLPVHAAYNSELNKSTKNETSPALLQASLEQHTMCHFFSLNQRCSCPNAYKHLKYGPPSCQQMGDCLCRQCAPTAGSFVHVQNSLAPLKAAHQAPEGFVHPAPHIHPCPGLQCRAKPPGAQNALPRSFFLHPVQHIQAQEKITKTSVHSLQSLEEHLPKTVEPSSLVCRSTGALHKACCGPETHPRGLCKNRDLGTTEGSGGATAKDSVSVSQTNKAERQVEPSPSQTDVIVSSEHLNQNEPKFLFNHLIGEAGYRSCPNNPQSCGRIVRVKCSSVDCQIPNIEANVPAVLTPSELSGESLLIKTL", "length": 1393, "header": "tr|A0A3Q1MC08-1|A0A3Q1MC08_BOVIN Computationally mapped isoform of Protein dispatched homolog 1 OS=Bos taurus OX=9913 GN=DISP1 PE=3 SV=2 CANONICAL=A0AAA9SRU9-1" }, "locus": { "chromosome": "16", "start_pos": 26518277, "end_pos": 26466657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077374.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077374.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071627.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071627.2" } ] } }, { "isoform_ac": "A0AAA9SRU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9/entry#A0AAA9SRU9-1", "sequence": { "sequence": "MAMSNGNSDFMVLSNGSIAARATTPTPLSPCDGDPAAQQLACKEAPRTKVSPNGCLQVNGTVKSSFLPLDNQRTPPVLPQCCHPCPYHHPLTPHDSHQECHPEAGPAAPPALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQHVPQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTVFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSAGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLEPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMAPKTADYTPALKYSMLFSPTEKGESMMNIYLDNFENWNASDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAMVIVLLVMCIYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSAFNIASPASQVWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISNELSSAPEGLSHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDADREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSASPGDKGPSKTHTLNAYHLDPRGQTSEMEHEFYELEPLAAHSCTASEKTTYEETHICSEFFSSQARHLGLPVHAAYNSELNKSTKNETSPALLQASLEQHTMCHFFSLNQRCSCPNAYKHLKYGPPSCQQMGDCLCRQCAPTAGSFVHVQNSLAPLKAAHQAPEGFVHPAPHIHPCPGLQCRAKPPGAQNALPRSFFLHPVQHIQAQEKITKTSVHSLQSLEEHLPKTVEPSSLVCRSTGALHKACCGPETHPRGLCKNRDLGTTEGSGGATAKDSVSVSQTNKAERQVEPSPSQTDVIVSSEHLNQNEPKFLFNHLIGEAGYRSCPNNPQSCGRIVRVKCSSVDCQIPNIEANVPAVLTPSELSGESLLIKTL", "length": 1532, "header": "tr|A0AAA9SRU9-1|A0AAA9SRU9_BOVIN Isoform 1 of Protein dispatched homolog 1 OS=Bos taurus OX=9913 GN=DISP1 PE=3 SV=2 CANONICAL=A0AAA9SRU9-1" }, "locus": { "chromosome": "16", "start_pos": 26518277, "end_pos": 26458476, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089692.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089692.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089109.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089109.2" } ] } }, { "isoform_ac": "A0ABI0NMI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9/entry#A0ABI0NMI7-1", "sequence": { "sequence": "MPSGARRKPGSGPDRSRRVPRHLSPQWMLLGAPAAAPRRGTRRPGSGNWSMAMSNGNSDFMVLSNGSIAARATTPTPLSPCDGDPAAQQLACKEAPRTKVSPNGCLQVNGTVKSSFLPLDNQRTPPVLPQCCHPCPYHHPLTPHDSHQECHPEAGPAAPPALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQHVPQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTVFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSAGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLEPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMAPKTADYTPALKYSMLFSPTEKGESMMNIYLDNFENWNASDGVTTVTGIEFGIKHSLFQDYLLMDTVYPAIAMVIVLLVMCIYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFSCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSAFNIASPASQVWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISNELSSAPEGLSHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDADREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSASPGDKGPSKTHTLNAYHLDPRGQTSEMEHEFYELEPLAAHSCTASEKTTYEETHICSEFFSSQARHLGLPVHAAYNSELNKSTKNETSPALLQASLEQHTMCHFFSLNQRCSCPNAYKHLKYGPPSCQQMGDCLCRQCAPTAGSFVHVQNSLAPLKAAHQAPEGFVHPAPHIHPCPGLQCRAKPPGAQNALPRSFFLHPVQHIQAQEKITKTSVHSLQSLEEHLPKTVEPSSLVCRSTGALHKACCGPETHPRGLCKNRDLGTTEGSGGATAKDSVSVSQTNKAERQVEPSPSQTDVIVSSEHLNQNEPKFLFNHLIGEAGYRSCPNNPQSCGRIVRVKCSSVDCQIPNIEANVPAVLTPSELSGESLLIKTL", "length": 1582, "header": "tr|A0ABI0NMI7-1|A0ABI0NMI7_BOVIN Computationally mapped isoform of Protein dispatched homolog 1 OS=Bos taurus OX=9913 GN=DISP1 PE=3 SV=1 CANONICAL=A0AAA9SRU9-1" }, "locus": { "chromosome": "16", "start_pos": 26518277, "end_pos": 26296474, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144105.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144105.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106611.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1022, "start_aa": "Thr", "end_pos": 1022, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1022", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1239, "end_pos": 1241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1244, "end_pos": 1246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 558, "end_pos": 560, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 625, "end_pos": 627, "annotation": "n_glycosylation_sequon" }, { "start_pos": 679, "end_pos": 681, "annotation": "n_glycosylation_sequon" }, { "start_pos": 835, "end_pos": 837, "annotation": "n_glycosylation_sequon" }, { "start_pos": 916, "end_pos": 918, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRU9" }, { "id": "PS50156", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50156" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SSD", "eco_id": "ECO_0000259", "start_pos": 523, "end_pos": 657, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1022 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1239, "end_pos": 1241 }, { "start_pos": 1244, "end_pos": 1246 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 15, "end_pos": 17 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 475, "end_pos": 477 }, { "start_pos": 558, "end_pos": 560 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 625, "end_pos": 627 }, { "start_pos": 679, "end_pos": 681 }, { "start_pos": 835, "end_pos": 837 }, { "start_pos": 916, "end_pos": 918 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SMX4-1", "uniprot_ac": "A0AAA9SMX4", "uniprot_id": "A0AAA9SMX4_BOVIN", "mass": { "chemical_mass": 71373.0, "monoisotopic_mass": 71373.0 }, "refseq": { "ac": "XP_024835185", "name": "zinc finger protein 805 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835185" }, "gene_names": [ { "name": "ZNF805", "type": "recommended", "evidence": [ { "id": "A0AAA9SMX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ] }, { "name": "ZNF805", "type": "synonym", "evidence": [ { "id": "XP_024835185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835185" } ] } ], "protein_names": [ { "name": "Zinc finger protein 805", "type": "synonym", "evidence": [ { "id": "A0AAA9SMX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 805 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024835185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835185" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1MQV2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQV2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF805", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4", "locus": { "chromosome": "18", "start_pos": 64476320, "end_pos": 64453980, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055478", "url": "https://www.ensembl.org/id/ENSBTAG00000055478" } ] } } ], "crossref": [ { "id": "A0AAA9SMX4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SMX4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048466", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048466", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523461", "url": "https://www.ncbi.nlm.nih.gov/gene/523461", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9843940", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843940", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024835185", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835185", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQV2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQV2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMAAAWMDPARLSVTFDDVAVTFTQEEWGHLDPAQRTLYQEVMLENCGLLVSLGCPVPRPELIYRLEHGQELWTVKRDLSRSTCAGDKGKPKTRESTTSEPSLFEGASVQEQLTQRVSEDSQLGQINNQEEPLERHEGCLRPEIEPQNGKLPGNPSCERGSLGTAGGVCSRIVEEQVPLGGAVHDRDSCGSGKDPLIQEEESLFKCNECGKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCTECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECTECGKAFNRRSGLTRHQRIHSGEKPYECMECGKTFCWSTNLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRVHTGRNPVNVTEVGRPFTSGQTSVNLQELLLGKDFLNVTTEENLLPEETSYSESDHSYQRETPQFSSL", "length": 628, "header": "tr|A0AAA9SMX4-1|A0AAA9SMX4_BOVIN Isoform 1 of Zinc finger protein 805 OS=Bos taurus OX=9913 GN=ZNF805 PE=3 SV=1 CANONICAL=A0AAA9SMX4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4/entry#A0A3Q1MQV2-1", "sequence": { "sequence": "MRPVPRRPLYPSAQDVGDKLFSRKRSRQGSSAGPRRRSWERSASQHVAVLCPGDIGQRLLHLPVTCGRCPVPRPELIYRLEHGQELWTVKRDLSRSTCAGDKGKPKTRESTTSEPSLFEGASVQEQLTQRVSEDSQLGQINNQEEPLERHEGCLRPEIEPQNGKLPGNPSCERGSLGTAGGVCSRIVEEQVPLGGAVHDRDSCGSGKDPLIQEEESLFKCNECGKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCTECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECTECGKAFNRRSGLTRHQRIHSGEKPYECMECGKTFCWSTNLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRVHTGRNPVNVTEVGRPFTSGQTSVNLQELLLGKDFLNVTTEENLLPEETSYSESDHSYQRETPQFSSL", "length": 642, "header": "tr|A0A3Q1MQV2-1|A0AAA9SMX4_BOVIN Computationally mapped isoform of Zinc finger protein 805 OS=Bos taurus OX=9913 GN=ZNF805 PE=3 SV=2 CANONICAL=A0AAA9SMX4-1" }, "locus": { "chromosome": "18", "start_pos": 64475316, "end_pos": 64464460, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077510.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077510.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072162.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072162.2" } ] } }, { "isoform_ac": "A0AAA9SMX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4/entry#A0AAA9SMX4-1", "sequence": { "sequence": "MMAAAWMDPARLSVTFDDVAVTFTQEEWGHLDPAQRTLYQEVMLENCGLLVSLGCPVPRPELIYRLEHGQELWTVKRDLSRSTCAGDKGKPKTRESTTSEPSLFEGASVQEQLTQRVSEDSQLGQINNQEEPLERHEGCLRPEIEPQNGKLPGNPSCERGSLGTAGGVCSRIVEEQVPLGGAVHDRDSCGSGKDPLIQEEESLFKCNECGKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCTECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECTECGKAFNRRSGLTRHQRIHSGEKPYECMECGKTFCWSTNLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRVHTGRNPVNVTEVGRPFTSGQTSVNLQELLLGKDFLNVTTEENLLPEETSYSESDHSYQRETPQFSSL", "length": 628, "header": "tr|A0AAA9SMX4-1|A0AAA9SMX4_BOVIN Isoform 1 of Zinc finger protein 805 OS=Bos taurus OX=9913 GN=ZNF805 PE=3 SV=1 CANONICAL=A0AAA9SMX4-1" }, "locus": { "chromosome": "18", "start_pos": 64475316, "end_pos": 64460732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125034.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125034.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085241.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085241.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9843940", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9843940", "resource": "Reactome", "description": "Regulation of endogenous retroelements by KRAB-ZFP proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SMX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 204, "end_pos": 231, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SMX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMX4" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 85, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 597, "end_pos": 599 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SNR6-1", "uniprot_ac": "A0AAA9SNR6", "uniprot_id": "A0AAA9SNR6_BOVIN", "mass": { "chemical_mass": 40398.0, "monoisotopic_mass": 40398.0 }, "refseq": { "ac": "NP_001179172", "name": "forkhead box protein I1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179172" }, "gene_names": [ { "name": "FOXI1", "type": "recommended", "evidence": [ { "id": "A0AAA9SNR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ] }, { "name": "FOXI1", "type": "synonym", "evidence": [ { "id": "NP_001179172", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179172" } ] } ], "protein_names": [ { "name": "Forkhead box protein L2", "type": "recommended", "evidence": [ { "id": "A0AAA9SNR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6/entry#names_and_taxonomy" } ] }, { "name": "forkhead box protein I1", "type": "synonym", "evidence": [ { "id": "NP_001179172", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179172" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FOXI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6", "locus": { "chromosome": "20", "start_pos": 2016057, "end_pos": 2011530, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014620", "url": "https://www.ensembl.org/id/ENSBTAG00000014620" } ] } } ], "crossref": [ { "id": "A0AAA9SNR6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SNR6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014620", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014620", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20053", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20053", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539442", "url": "https://www.ncbi.nlm.nih.gov/gene/539442", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539442", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539442", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GIIYHRE", "url": "https://omabrowser.org/oma/group/GIIYHRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPY1", "url": "https://www.orthodb.org/?gene=E1BPY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829:SF180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829:SF180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179172", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPY1", "url": "https://www.uniprot.org/uniprotkb/E1BPY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSFDLPAPSPPRCSPQFPSLGQEPPEMNLYYENFFHPQGAPSPQRPPSFEGGGEYGAAPNPYLWLNGPAVTPPPYLPGGSPFLPQAYGGVQRQLLPTGMPTLGAGDLGWLPLPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTGSMASEKTEAGLLAGSPKTAEAQDILDGAAPGPTGSPEKQPTPPPPGTPCLSSFLSTMSAYVSGPSPVSRPAATTPGLSLEPADKGGQNSLSFSSYTPLTNISGPVGGGEWASPMPSNALGYGGSVLNQFSSPFYGSVSTNSVLYPREGTEV", "length": 379, "header": "tr|A0AAA9SNR6-1|A0AAA9SNR6_BOVIN Isoform 1 of Forkhead box protein L2 OS=Bos taurus OX=9913 GN=FOXI1 PE=4 SV=1 CANONICAL=A0AAA9SNR6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6/entry#A0AAA9SNR6-1", "sequence": { "sequence": "MSSFDLPAPSPPRCSPQFPSLGQEPPEMNLYYENFFHPQGAPSPQRPPSFEGGGEYGAAPNPYLWLNGPAVTPPPYLPGGSPFLPQAYGGVQRQLLPTGMPTLGAGDLGWLPLPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTGSMASEKTEAGLLAGSPKTAEAQDILDGAAPGPTGSPEKQPTPPPPGTPCLSSFLSTMSAYVSGPSPVSRPAATTPGLSLEPADKGGQNSLSFSSYTPLTNISGPVGGGEWASPMPSNALGYGGSVLNQFSSPFYGSVSTNSVLYPREGTEV", "length": 379, "header": "tr|A0AAA9SNR6-1|A0AAA9SNR6_BOVIN Isoform 1 of Forkhead box protein L2 OS=Bos taurus OX=9913 GN=FOXI1 PE=4 SV=1 CANONICAL=A0AAA9SNR6-1" }, "locus": { "chromosome": "20", "start_pos": 2015053, "end_pos": 2012311, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125772.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125772.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085538.1" } ] } }, { "isoform_ac": "E1BPY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6/entry#E1BPY1-1", "sequence": { "sequence": "MSSFDLPAPSPPRCSPQFPSLGQEPPEMNLYYENFFHPQGAPSPQRPPSFEGGGEYGAAPNPYLWLNGPAVTPPPYLPGGSPFLPQAYGGVQRQLLPTGMPTLGAGDLGWLPLPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGDLPNPGIKRRSLASQMDSSLSEPPGKPIEMHRGKRKRKSDVSSSTGSMASEKTEAGLLAGSPKTAEAQDILDGAAPGPTGSPEKQPTPPPPGTPCLSSFLSTMSAYVSGPSPVSRPAATTPGLSLEPADKGGQNSLSFSSYTPLTNISGPVGGGEWASPMPSNALGYGGSVLNQFSSPFYGSVSTNSVLYPREGTEV", "length": 390, "header": "tr|E1BPY1-1|E1BPY1_BOVIN Computationally mapped isoform of Forkhead box I1 OS=Bos taurus OX=9913 GN=FOXI1 PE=4 SV=2 CANONICAL=A0AAA9SNR6-1" }, "locus": { "chromosome": "20", "start_pos": 2015053, "end_pos": 2012311, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019467.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019467.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019467.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019467.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 261, "start_aa": "Thr", "end_pos": 261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr261", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 72, "start_aa": "Thr", "end_pos": 72, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr72", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539442", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539442", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RR95-1", "protein_name": "Forkhead box protein L2", "gene_name": "FOXI1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHAQGVPSPQRPPSFEGGGEFGATPNPYLWLNGPAMTPPPYLPGTSASPFLPQTYGVQRQLLPGVSGLGGGDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTGSLASEKTETSLLGGSAKAAEAQDLLDGASPGPGGSPEKRASPPPPATPCLNGFLSTVSAYVSGSGPGSRPVATPGLSPEPADKLAQNLLNFNSYTTLGNISGHAGGGEWAPPAPGSTLGYGGAALNQFSPHFYNGINTNGILYPREGSEV", "length": 378 }, "evidence": [ { "id": "A0AAA9SNR6", "url": "https://omabrowser.org/oma/group/A0AAA9SNR6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q922I5-1", "protein_name": "Forkhead box protein I1", "gene_name": "Foxi1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGMPSPQRPTSFEGGGEYGTTPNPYLWLNGPAMTPPPYLPGTNASPFLPQAYGMQRQLLPSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDQRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDSSSSTSSLASEKTENGLLASSPKPTEPQEVLDTASPDTTTSSPEKRSSPAPSGTPCLNNFLSTMTAYVSGTNPISRSVATPGLSSEPIDKMGQNSLNFNSYTPLTNLSSHGNGGEWANPVATNALGYGGSVFNQFSPHFYNSINTNGILFPREGTEV", "length": 372 }, "evidence": [ { "id": "A0AAA9SNR6", "url": "https://omabrowser.org/oma/group/A0AAA9SNR6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SNR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNR6" }, { "id": "PS50039", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50039" }, { "id": "PRU00089", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fork-head", "eco_id": "ECO_0000259", "start_pos": 124, "end_pos": 218, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 72, 261 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 328, "end_pos": 330 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPT2-1", "uniprot_ac": "A0AAA9SPT2", "uniprot_id": "A0AAA9SPT2_BOVIN", "mass": { "chemical_mass": 63919.0, "monoisotopic_mass": 63919.0 }, "refseq": {}, "gene_names": [ { "name": "HRG", "type": "recommended", "evidence": [ { "id": "A0AAA9SPT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ] } ], "protein_names": [ { "name": "Histidine-rich glycoprotein", "type": "recommended", "evidence": [ { "id": "A0AAA9SPT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2/entry#names_and_taxonomy" } ] }, { "name": "Histidine-proline-rich glycoprotein", "type": "synonym", "evidence": [ { "id": "A0AAA9SPT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HRG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2", "locus": { "chromosome": "1", "start_pos": 80535975, "end_pos": 80547148, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001265", "url": "https://www.ensembl.org/id/ENSBTAG00000001265" } ] } } ], "crossref": [ { "id": "A0AAA9SPT2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13814:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13814:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESPWFNRSGGGLDIRILKSSSAAIAKSLQSCPTLCDPIDSSPTRFPRPWDSQGCDAVEPVAVRALDLINKGRWDGYLFQLLRVADAHLDKVESIAVYYLVLDVKESDCPVLSRKHWDDCELNVSRRPSETVIGQCKVIAITLLAGPEDLRVNDFNCTTSSVSSALTNTIDSPVLFDFFEDTELYRKQAEKALEKYQRENSDFAPFRVDKVKRAMRARGGEGTSYFLDFSVRNCSSHHFPRHSHIFGFCRADLFYDVEASDLETPKDIVTNCEVFNLKEHRNFSAVQHHLGRPFHSGEHEHSPAGRPPFKPSGSKDHGHPHESYNFRCPPPLEHKNHSDSPPFQARAPLPFPPPGLRCPHPPFGTKGNHRPPHDHSSDEHHPHGHHPHGHHPHGHHPHGHHPHGHQPHGHHPHGHHPHGHHPHGHHPHGHHPYGHHPHGHHPHDNDFYDHGPCDPPPHRQDPQDHHRQGRDPPPRHSKERGPGKGHFRFHWRPTGYIHRLPSLKKGEVLPLPEANFPSFSLPNHNNPLQPEIQAFPQSASESCPGTFNIKFLHISKFFAYTLPK", "length": 564, "header": "tr|A0AAA9SPT2-1|A0AAA9SPT2_BOVIN Isoform 1 of Histidine-rich glycoprotein OS=Bos taurus OX=9913 GN=HRG PE=4 SV=1 CANONICAL=A0AAA9SPT2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2/entry#A0AAA9SPT2-1", "sequence": { "sequence": "MESPWFNRSGGGLDIRILKSSSAAIAKSLQSCPTLCDPIDSSPTRFPRPWDSQGCDAVEPVAVRALDLINKGRWDGYLFQLLRVADAHLDKVESIAVYYLVLDVKESDCPVLSRKHWDDCELNVSRRPSETVIGQCKVIAITLLAGPEDLRVNDFNCTTSSVSSALTNTIDSPVLFDFFEDTELYRKQAEKALEKYQRENSDFAPFRVDKVKRAMRARGGEGTSYFLDFSVRNCSSHHFPRHSHIFGFCRADLFYDVEASDLETPKDIVTNCEVFNLKEHRNFSAVQHHLGRPFHSGEHEHSPAGRPPFKPSGSKDHGHPHESYNFRCPPPLEHKNHSDSPPFQARAPLPFPPPGLRCPHPPFGTKGNHRPPHDHSSDEHHPHGHHPHGHHPHGHHPHGHHPHGHQPHGHHPHGHHPHGHHPHGHHPHGHHPYGHHPHGHHPHDNDFYDHGPCDPPPHRQDPQDHHRQGRDPPPRHSKERGPGKGHFRFHWRPTGYIHRLPSLKKGEVLPLPEANFPSFSLPNHNNPLQPEIQAFPQSASESCPGTFNIKFLHISKFFAYTLPK", "length": 564, "header": "tr|A0AAA9SPT2-1|A0AAA9SPT2_BOVIN Isoform 1 of Histidine-rich glycoprotein OS=Bos taurus OX=9913 GN=HRG PE=4 SV=1 CANONICAL=A0AAA9SPT2-1" }, "locus": { "chromosome": "1", "start_pos": 80547020, "end_pos": 80536979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130657.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130657.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087378.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 18, "go_terms": [ { "name": "positive regulation of blood vessel remodeling", "id": "GO:2000504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000504", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "antimicrobial humoral immune response mediated by antimicrobial peptide", "id": "GO:0061844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061844", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "platelet activation", "id": "GO:0030168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of cell adhesion mediated by integrin", "id": "GO:0033629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "fibrinolysis", "id": "GO:0042730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "positive regulation of focal adhesion assembly", "id": "GO:0051894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051894", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of vascular endothelial growth factor signaling pathway", "id": "GO:1900747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900747", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "cytolysis by host of symbiont cells", "id": "GO:0051838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051838", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "positive regulation of immune response to tumor cell", "id": "GO:0002839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of lamellipodium assembly", "id": "GO:0010593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell chemotaxis", "id": "GO:2001027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "heparan sulfate proteoglycan binding", "id": "GO:0043395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043395", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "immunoglobulin binding", "id": "GO:0019865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SPT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT2" }, { "id": "SM00043", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00043" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cystatin", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 158, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRW6-1", "uniprot_ac": "A0AAA9SRW6", "uniprot_id": "A0AAA9SRW6_BOVIN", "mass": { "chemical_mass": 82319.0, "monoisotopic_mass": 82319.0 }, "refseq": { "ac": "XP_059739289", "name": "U3 small nucleolar RNA-associated protein 14 homolog A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739289" }, "gene_names": [ { "name": "UTP14A", "type": "recommended", "evidence": [ { "id": "A0AAA9SRW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6" } ] }, { "name": "UTP14A", "type": "synonym", "evidence": [ { "id": "XP_059739289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739289" } ] }, { "name": "UTP14C", "type": "synonym", "evidence": [ { "id": "XP_059739289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739289" } ] } ], "protein_names": [ { "name": "U3 small nucleolar RNA-associated protein 14 homolog A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059739289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739289" } ] }, { "name": "UTP14A small subunit processome component", "type": "synonym", "evidence": [ { "id": "A0AAA9SRW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UTP14A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6", "locus": { "chromosome": "X", "start_pos": 13937434, "end_pos": 13920836, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013671", "url": "https://www.ensembl.org/id/ENSBTAG00000013671" } ] } } ], "crossref": [ { "id": "A0AAA9SRW6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "505324", "url": "https://www.ncbi.nlm.nih.gov/gene/505324", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14150", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14150", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14150:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14150:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059739289", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739289", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYFGDCRQKLADRSEASLKVSEFSVSSEGSGEKLVLSDLLEPVKTSSSLAAVKKQLNRVKSKKTVELPLHREEIERIHREVAFNKSSQILSKWDPVVLKNRQAEQLVFPLSKPQSAFAPIEHVVNGWKAGTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEVKMRRAELQRARALQSYYEARARREKRIKSKKYHRILKKGKAKQALKDFEKLQKVNPAAALEELEKLDKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLARNKELTQKVRAASESEEEGEGQEEEEEPLVPDLVNEVQIKANGLNPWMFRNHFIDAKEAEVQKDLEDPAEPEAQETSESEEEKAVVEEETLLKEFEERRSLRQKSELNHMAEPVHRRVTKDPSSQEVLSDLRALCQKLRTENHQSGKQELSSARTAQREEPAREEEEPMLLQRPERARTLDELEELGREGCVENEELPRTAVEGLQLEKNLSNHIGAPKEKKRKEQMIDLQNLLTTKSPSVKSLAVPTTVQELEDEEERDQRQIIKEAFAGDDVIRDFLKEKREAVEASKPKDLDLTLPGWGEWGGIGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNTHAAAHQVQVLPHPFTHHQQFERTIQTPVGSTWNTQRAFQKLTMPKVVTKPGHIIKPIKAEDVGYRSSSRSDLSVVQRNPKRLSIRHKKHLENNCVD", "length": 718, "header": "tr|A0AAA9SRW6-1|A0AAA9SRW6_BOVIN Isoform 1 of UTP14A small subunit processome component OS=Bos taurus OX=9913 GN=UTP14A PE=3 SV=1 CANONICAL=A0AAA9SRW6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6/entry#A0AAA9SRW6-1", "sequence": { "sequence": "MYFGDCRQKLADRSEASLKVSEFSVSSEGSGEKLVLSDLLEPVKTSSSLAAVKKQLNRVKSKKTVELPLHREEIERIHREVAFNKSSQILSKWDPVVLKNRQAEQLVFPLSKPQSAFAPIEHVVNGWKAGTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEVKMRRAELQRARALQSYYEARARREKRIKSKKYHRILKKGKAKQALKDFEKLQKVNPAAALEELEKLDKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLARNKELTQKVRAASESEEEGEGQEEEEEPLVPDLVNEVQIKANGLNPWMFRNHFIDAKEAEVQKDLEDPAEPEAQETSESEEEKAVVEEETLLKEFEERRSLRQKSELNHMAEPVHRRVTKDPSSQEVLSDLRALCQKLRTENHQSGKQELSSARTAQREEPAREEEEPMLLQRPERARTLDELEELGREGCVENEELPRTAVEGLQLEKNLSNHIGAPKEKKRKEQMIDLQNLLTTKSPSVKSLAVPTTVQELEDEEERDQRQIIKEAFAGDDVIRDFLKEKREAVEASKPKDLDLTLPGWGEWGGIGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNTHAAAHQVQVLPHPFTHHQQFERTIQTPVGSTWNTQRAFQKLTMPKVVTKPGHIIKPIKAEDVGYRSSSRSDLSVVQRNPKRLSIRHKKHLENNCVD", "length": 718, "header": "tr|A0AAA9SRW6-1|A0AAA9SRW6_BOVIN Isoform 1 of UTP14A small subunit processome component OS=Bos taurus OX=9913 GN=UTP14A PE=3 SV=1 CANONICAL=A0AAA9SRW6-1" }, "locus": { "chromosome": "X", "start_pos": 13937260, "end_pos": 13922935, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096074.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096074.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086820.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086820.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 487, "end_pos": 489 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SPU1-1", "uniprot_ac": "A0AAA9SPU1", "uniprot_id": "A0AAA9SPU1_BOVIN", "mass": { "chemical_mass": 89576.0, "monoisotopic_mass": 89576.0 }, "refseq": {}, "gene_names": [ { "name": "ELP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SPU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ] } ], "protein_names": [ { "name": "Elongator complex protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SPU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1", "locus": { "chromosome": "24", "start_pos": 20958748, "end_pos": 21006451, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018954", "url": "https://www.ensembl.org/id/ENSBTAG00000018954" } ] } } ], "crossref": [ { "id": "A0AAA9SPU1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SPU1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018954", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018954", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511041", "url": "https://www.ncbi.nlm.nih.gov/gene/511041", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511041", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511041", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ENFRHIS", "url": "https://omabrowser.org/oma/group/ENFRHIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEP7", "url": "https://www.orthodb.org/?gene=E1BEP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44111", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44111:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44111:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S2X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2X4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEP7", "url": "https://www.uniprot.org/uniprotkb/E1BEP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEP7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAPMLETSHVFCCPNRVRGALSWSPGPGGLLAFGTSCSVVLYDPQKRVVITNLNGHTARVNCLQWICKQDGSPSTELVSGGSDNQVIHWEIENNQLLQAVHVSGHEGPVYAVHAVYQRMAPGIALHTLIVSAASDSTVRVWSKQGSEVPVLACGDDDCKIHLFVQQNNQFQKMLFLSGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWRLYVKSTSLETQEDDDNIKLKENTFNVENESIKITFAVTLETVLAGHENWVNAVHWQPSFYKDGILQQPMRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNATNPKEWTPEIVISGHFDGVQDLTWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMISRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSMNHVLCDQDGDLPEGATVPALGLSNKAVFQGDMASQHSDEEELFSSAGFEYHQVAFQPSLLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVACSNSKTLLASACKAAKKEHAAIILWNTASWKQVQNLIFHSLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDTIPPELDPVFSLFAFTNKVTAVHSRIIWSCDWSPDGKYFFTGSRDRKVVVWGECDSSDDAVEHSIGPCSSVLDVGGAVTAVSVCPVLNLSQRYVVAVGLECGKICLYSWEKTDQVPEINDWIRCVETSQSQSHTLAIKKLCWKNCNGKTEQNEGEGAEWLQFASCGEDHTVKIHRVNRCAL", "length": 801, "header": "tr|A0AAA9SPU1-1|A0AAA9SPU1_BOVIN Isoform 1 of Elongator complex protein 2 OS=Bos taurus OX=9913 GN=ELP2 PE=3 SV=1 CANONICAL=A0AAA9SPU1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1/entry#A0AAA9S2X4-1", "sequence": { "sequence": "MVAPMLETSHVFCCPNRVRGALSWSPGPGGLLAFGTSCSVVLYDPQKRVVITNLNGHTARVNCLQWICKQDGSPSTELVSGGSDNQVIHWEIENNQLLQAVHVSGHEGPVYAVHAVYQRMAPGIALHTLIVSAASDSTVRVWSKQGSEGRDLFLASCSQDCLIRIWRLYVKSTSLETQEDDDNIKLKENTFNVENESIKITFAVTLETVLAGHENWVNAVHWQPSFYKDGILQQPMRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNATNPKEWTPEIVISGHFDGVQDLTWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMISRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSMNHVLCDQDGDLPEGATVPALGLSNKAVFQGDMASQHSDEEELFSSAGFEYHQVAFQPSLLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVACSNSKTLLASACKAAKKEHAAIILWNTASWKQVQNLIFHSLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDTIPPELDPVFSLFAFTNKVTAVHSRIIWSCDWSPDGKYFFTGSRDRKVVVWGECDSSDDAVEHSIGPCSSVLDVGGAVTAVSVCPVLNLSQRYVVAVGLECGKICLYSWEKTDQVPEINDWIRCVETSQSQSHTLAIKKLCWKNCNGKTEQNEGEGAEWLQFASCGEDHTVKIHRVNRCAL", "length": 757, "header": "tr|A0AAA9S2X4-1|A0AAA9SPU1_BOVIN Computationally mapped isoform of Elongator complex protein 2 OS=Bos taurus OX=9913 GN=ELP2 PE=3 SV=1 CANONICAL=A0AAA9SPU1-1" }, "locus": { "chromosome": "24", "start_pos": 21006380, "end_pos": 20959162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130886.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130886.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080271.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080271.1" } ] } }, { "isoform_ac": "A0AAA9SPU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1/entry#A0AAA9SPU1-1", "sequence": { "sequence": "MVAPMLETSHVFCCPNRVRGALSWSPGPGGLLAFGTSCSVVLYDPQKRVVITNLNGHTARVNCLQWICKQDGSPSTELVSGGSDNQVIHWEIENNQLLQAVHVSGHEGPVYAVHAVYQRMAPGIALHTLIVSAASDSTVRVWSKQGSEVPVLACGDDDCKIHLFVQQNNQFQKMLFLSGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWRLYVKSTSLETQEDDDNIKLKENTFNVENESIKITFAVTLETVLAGHENWVNAVHWQPSFYKDGILQQPMRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNATNPKEWTPEIVISGHFDGVQDLTWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMISRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSMNHVLCDQDGDLPEGATVPALGLSNKAVFQGDMASQHSDEEELFSSAGFEYHQVAFQPSLLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVACSNSKTLLASACKAAKKEHAAIILWNTASWKQVQNLIFHSLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDTIPPELDPVFSLFAFTNKVTAVHSRIIWSCDWSPDGKYFFTGSRDRKVVVWGECDSSDDAVEHSIGPCSSVLDVGGAVTAVSVCPVLNLSQRYVVAVGLECGKICLYSWEKTDQVPEINDWIRCVETSQSQSHTLAIKKLCWKNCNGKTEQNEGEGAEWLQFASCGEDHTVKIHRVNRCAL", "length": 801, "header": "tr|A0AAA9SPU1-1|A0AAA9SPU1_BOVIN Isoform 1 of Elongator complex protein 2 OS=Bos taurus OX=9913 GN=ELP2 PE=3 SV=1 CANONICAL=A0AAA9SPU1-1" }, "locus": { "chromosome": "24", "start_pos": 21006380, "end_pos": 20959162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134087.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134087.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084943.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084943.1" } ] } }, { "isoform_ac": "A0AAA9STN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1/entry#A0AAA9STN4-1", "sequence": { "sequence": "MVAPMLETSHVFCCPNRVRGALSWSPGPGGLLAFGTSCSVVLYDPQKRVVITNLNGHTARVNCLQWICKQDGSPSTELVSGGSDNQVIHWEIENNQLLQAVHVSGHEGPVYAVHAVYQRMAPGIALHTLIVSAASDSTVRVWSKQGSEVPVLACGDDDCKIHLFVQQNNQFQKMLFLSGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWRLYVKSTSLETQEDDDNIKLKENTFNVENESIKITFAVTLETVLAGHENWVNAVHWQPSFYKDGILQQPMRLLSASMDKTMILWAPDEESGVWLEQKEWTPEIVISGHFDGVQDLTWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMISRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSMNHVLCDQDGDLPEGATVPALGLSNKAVFQGDMASQHSDEEELFSSAGFEYHQVAFQPSLLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVACSNSKTLLASACKAAKKEHAAIILWNTASWKQVQNLIFHSLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDTIPPELDPVFSLFAFTNKVTAVHSRIIWSCDWSPDGKYFFTGSRDRKVVVWGECDSSDDAVEHSIGPCSSVLDVGGAVTAVSVCPVLNLSQRYVVAVGLECGKICLYSWEKTDQVPEINDWIRCVETSQSQSHTLAIKKLCWKNCNGKTEQNEGEGAEWLQFASCGEDHTVKIHRVNRCAL", "length": 757, "header": "tr|A0AAA9STN4-1|A0AAA9STN4_BOVIN Computationally mapped isoform of Elongator complex protein 2 OS=Bos taurus OX=9913 GN=ELP2 PE=3 SV=1 CANONICAL=A0AAA9SPU1-1" }, "locus": { "chromosome": "24", "start_pos": 21006380, "end_pos": 20959162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112794.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112794.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087499.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087499.1" } ] } }, { "isoform_ac": "E1BEP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1/entry#E1BEP7-1", "sequence": { "sequence": "MVAPMLETSHVFCCPNRVRGALSWSPGPGGLLAFGTSCSVVLYDPQKRVVITNLNGHTARVNCLQWICKQDGSPSTELVSGGSDNQVIHWEIENNQLLQAVHVSGHEGPVYAVHAVYQRMAPGIALHTLIVSAASDSTVRVWSKQGSEVTCLQTLNFGNGFALALCLSFLPNIDVPVLACGDDDCKIHLFVQQNNQFQKMLFLSGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWRLYVKSTSLETQEDDDNIKLKENTFNVENESIKITFAVTLETVLAGHENWVNAVHWQPSFYKDGILQQPMRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNATNPKEWTPEIVISGHFDGVQDLTWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMISRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSMNHVLCDQDGDLPEGATVPALGLSNKAVFQGDMASQHSDEEELFSSAGFEYHQVAFQPSLLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVACSNSKTLLASACKAAKKEHAAIILWNTASWKQVQNLIFHSLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDTIPPELDPVFSLFAFTNKVTAVHSRIIWSCDWSPDGKYFFTGSRDRKVVVWGECDSSDDAVEHSIGPCSSVLDVGGAVTAVSVCPVLNLSQRYVVAVGLECGKICLYSWEKTDQVPEINDWIRCVETSQSQSHTLAIKKLCWKNCNGKTEQNEGEGAEWLQFASCGEDHTVKIHRVNRCAL", "length": 827, "header": "tr|E1BEP7-1|E1BEP7_BOVIN Computationally mapped isoform of Elongator complex protein 2 OS=Bos taurus OX=9913 GN=ELP2 PE=3 SV=1 CANONICAL=A0AAA9SPU1-1" }, "locus": { "chromosome": "24", "start_pos": 21006380, "end_pos": 20959162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025227.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025227.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025227.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025227.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511041", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511041", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QCK5-1", "protein_name": "Elongator complex protein 2", "gene_name": "ELP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVAPVLETSHVFCCPNRVRGALSWSSGPGGLLAFGTSCSVVLYDPQKRVVITNLNGHTARVNCLQWICKQNGSPSTELVSGGSDNQVIHWEIENNQLLKAVHLPGHEGPIYAVHAVYQKRASDTAFRTLIVSAASDSTVRVWSKQGFEVPILACGDDDCKIHLFVQQNDQFQNVLFLSGHEDWIRGVEWAAFGRDLFLATCSQDCLIRIWKLYIKSVSFETQEDDHIRLKENTFAIENESNKIAFAVTLETVLAGHENWVNAVHWQPPFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNATNLREWVPEIVISGHFDGVQDLTWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMISRFQFVSGADEKVLRVFSAPRNFVENFCIITGQSLNHVLGNQEGDLPEGATVPALGLSNKAVFQGDVASQPSDEEELLSGSGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVACNNSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDTIPPELDPVFSLFAFTNKVTAVHSRIIWSCDWSPDGKYFFTGSRDKKVVAWGECDSGDDSIEHSIGPCSSVLDVGGAVTAVSVCPVLNLSQRYIVAVGLECGKISLYSWKKTNQVPEINDWIHCVKTSQSQSHTLAIKKLCWKNCNGKTEQNEAEGTEWLHFASCGEDHTVKIHRVNRYAL", "length": 800 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4I1S7-1", "protein_name": "Elongator complex protein 2", "gene_name": "ELP2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSENTKVEAKRVFIGAGCNRVVNNVSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPTSKFAFKAKKLDRQYLLSGDSDGIIILWELSTLNNDWRHVLQLPLSHKKGVTCITAYMVSETDAMFASASSDGVVNVWDVSFPSQPSEECKVVCLDSICVDTKAIVTLSLAELPQNPGRFALALGGLDNKIKLYSGERTGKFTSVCELKGHTDWIRSLDFSLPLHTTEEIPNSIMLVSSSQDKVIRIWKLVLVGDVGSWRREITLASYIEGPVFVSGTFTYQISVESVLIGHEDWVYSVEWQPPVIDFIDGRLVNHQPLSILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSKESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKNDEGNEAEDEHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSFLKTLNHTCAGGEGSFPEDLQADVQVLGANMSALGLSQKPIYLHSSSEPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTDNGEVSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKQILVLPPFGSSVTAVAWTGLDRNEKSGCVAVGMESGLIELSNVKIIETEEGTTATAALALRLEPFMCHVSAVNRLAWRPTEKCESNQSLRWLTSCGDDNCVRVFNFKF", "length": 838 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P42935-1", "protein_name": "Elongator complex protein 2", "gene_name": "ELP2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLAYE", "length": 788 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q05AM5-1", "protein_name": "Elongator complex protein 2", "gene_name": "elp2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAPVMDTCHVSCCANRAPNVVSWGRGGLIAFGTCNSVAIYNPEEIRVVDLLNKHTGRVNAVQWVHEPDCSPENQLISGGSDNNVIVWEKLDGKFRACAVCSGHSGPVCAVDAVSLSSSHLLVASASSDSTVKLWTYSSDAAECLQTVAFGSGFMMDVSLALLPGSRVPVLACGGDDSRVHLYVQLSGQFQRVLTLTGHEDWVRGVEWANKDGELWLASCSQDCLIRVWRLFAKTAAEPDLQTDGIIKMKENIFQVSGEEFAVTLETVLAGHENWVYGIHWQPPSVKGDSVEQSLKLLSASMDKTMILWGPEEDSGMWVEMVRVGEVGGNTLGFYGCQMSPDGSMILAHAFHGALHLWHHDSNQEWRPSVVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLFTPWTRKGSSQITWHEISRPQIHGYDMQCLTMVGRFQFVSGADEKVLRVFKAPRNFVENFAHISGTSLEKLLGCNDIADLPEGASTPALGLSNKAVFQGDLASPSPQQDGGDFNSLSDQYKESYFQPLKLAEPPTEDDLLQNTLWPEVQKLYGHGFEMFCLASDCARTVVASACKASKAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWRRGNPDLDTEAMFSLYANTSKDTSVHTRIIWSCDWSADNKYFVTSSRDKKVIIWGHAVSGVAVGEGEDARVTSCSSVLDVGDSATAVSICPFLCSDHSYLLAVGLENGQILLYKWKPLEDLSSESDWSRCKDTDACQGHTMVVKRLRWRPRLGRGGHGGQDSKEEQAWVQLASAGADHVVKIFDINLSAL", "length": 821 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q496Z0-1", "protein_name": "Elongator complex protein 2", "gene_name": "Elp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSSVLEVSYVFCCPNRARGALSWNSGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLHWIRTEDGSPSTELVSGASDNRVIHWELENNQVLKSVRLQGHEGPVYAVHGIYQSGPSDGEQHALIASAASDSTVRLWSKKGSEVKCLQILKFGDGFVLTVCLSTLPDTDAPVLACGDDGGRIHLFVQQDDWFQKMLSLCGHEDWIRGVEWATFGRDLFLASCSQDCLIRIWRLYMKPTSLETEDGSIRLKENTFTIKDGGVSTTVAVILETVLAGHENWVNAIHWQPSFYKDGVLHQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYGCQFGENGSMIIAHAFHGAMHLWKQSTVNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLFAPWKKKNQSQVTWHEIARPQIHGYNLKCLAMIDRFQFVSGADEKVLRVFSAPRNFVENFSVISRQSLSHMLYDEDNDLPEGATVPALGLSNKAVFEGDMTYLTSEEEELLSPAFGYPQVIFQPAVLSEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNNSKTLLASACKAAQKEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDVTSAEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECNSSYNPMEHPINPCSSILDVGSCVTAVSVCPVLNPAQRYIVAVGLESGKICIYSWSKTNQETKDWTSCVETTPSQSHTLGIRRLCWKSCSGSTEQSEEGTEWLDFASCGEDHTVKIYRVNRCAL", "length": 821 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6IA86-1", "protein_name": "Elongator complex protein 2", "gene_name": "ELP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL", "length": 826 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7K4B3-1", "protein_name": "Elongator complex protein 2", "gene_name": "Elp2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQVENLHTSVACNRCTECADWGPNGWIAYGACNAIAIMDPKFQGNSAKVLFTLVEHTKRVNTVRWLDCDKLLSGGDDAIAILWELDETGTTKSFTLKGHTSGVNTVDGIRQQDGSWLLATAAADTTIKLWTFQDNNYVCFQTISLSDGFCFCLRLQLLPKSNQVLLAFSGDDETVSLWSEQVETAGEGDSLGRQFQRKHKLTGHEDWVRGLDFVVDGEDLLLASGSQDNFIRLWRIAPRSKEQMQENRVDLHQLSHNDDEIKVEEKILQLGKEAWYAVSLESVLYGHEGWIYGVHWHKTPDQELRLLSASIDKTVIIWAPTEEGIWLEEVRVGEVGGNSVGFYGGKFSGDGHSIMAHSYQGGFHIWSQDPDRPQLWTPGVIVGGHYGEVRDLAWEHSGAYLMTASADQTTRLHAPWLQDGANPTWHELARPQIHGYDMQALALLSRYKFASGAEEKIVRTFQAPANFIENFRHISGIENDDAGDVLLDSLPKGASVPSLGLSNKAVYKVDSEVESTSKTSKDEYPDNYFVPIALETPPQEETLMQNTLWPELQKLYGHGYEIFALAATADGSLLASTCKASNAEHAQIILWNPSNWKQIQKLSGHQLTVTQLSFSPDSRYLLSVSRDRRWCLYERQDSSVSYQLVASTDKSNGVHTRIIWSCDWSHDGQFFVTSSRDGKVVVWKKEEDCKESSLNGWQANGVLELKNESITAVAFSNSYLSGTDDTYILALGTETGLIKIYQFVRGAWKLLSDLNKSQAHHLTVRRLQFRPGKQLQLASCGEDHLVRIYDIKLT", "length": 794 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q86H45-1", "protein_name": "Elongator complex protein 2", "gene_name": "elp2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNVSSDVDFISVGCNCLGDCLVWGQNKLAAYGAQNFIALFDPIQSKVLATLPGHKDRVNHICWVPNINEEYKNRYSSYENELLSCSSDNTIISWKQIKGGLNYQYKVVEVLKGHSDSVTNISVLDFPDGSLLMCSTSADNTVKLWRRESLTKENIDTDTLPKWECIQTIDFTPKCMECSSLAFIPGTTIPLLAVGGLEPKIHIYIQNLDSTTATLQFKKLMSLQGHQDWIRSLSFKTINEGEGEGEEEELILASSSQDFKIRLWKISKFTAEKQKQQQLDESGNGGANLLGSLSTQLSGVTSLSTKGYLFNCNSVKYIILLDAVLSGHDDWVYSIHWSPARRDQETGKKIQEQMLISASMDKTAIVWRPDRTTGIWIDESRVGDMGGNILGQYGAVFSPCSQYILSHGYNGAFHFWKQNTNQKSSFWEPQIVVSGHFGPVQDLMWSPDYSYFISCSTDRTLRLFSEWKRNNNNNNLENNKEQQIISWNEIARPQIHGYDLECFTFINKKTHVIVSGAEEKIMRAFVGSQNFVDTLLNISKVQPVNDGTQRPLAANQPSLGLSNKPYFTGGSDYNENIDNNNNNNNNNGNGEENTEDSIKMKMGGGDEGGGGEGMDTGYFEDEIPFNPEVLSEPPFEEHLLQSSLWPEIHKFYGHGNEIVAVACSADGMYLASTCRASSADQATVRIWNVSNWKECANLKGHTLTVVNLSFSHNSKYLLGVSRDRMWTLWERSASNSEEPFVKVISAPKSHGRIIWSGSWSHDDKFFATGARDKLVKVWNLDNIKDIKNACASTLPAFGSGVTCVEFAPKSSKFTGEHGDHLLAVGEDDGKITIWKSTTSTSNPKSLDWTCVHTISPLISHTLDVRRIRWRDTPTINGNSLTYQIVTCSVDHSVRIFNIKFD", "length": 901 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q91WG4-1", "protein_name": "Elongator complex protein 2", "gene_name": "Elp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSSVLEVSHVFCCPNRVRGALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWIRTEDGSPSNELVSGGSDNRVIHWELENNQVLKSVRLQGHEGPVCAVHAIYQSGPSEGEQHALIASAASDSTVRIWSKKGSEVKYLQTLSFRDGFVLSVCLAILPGTNVPVLACGDDDCRIHLYIQQDDQFQKALSLCGHEDWIRGVEWATFGRDLFLASCSQDCLIRIWRLYMKPASFETKDGSLRLKENTFTIKDGGVRTTVAVTLETVLAGHENWVNAVHWQPSFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFAPWKKKDQKDRSQVTWHEIARPQIHGYNIKCLAMIDRFQFVSGADEKVLRVFSAPRNFVENFSVISRQSLSHMLCDDQDLPEGATVPALGLSNKALFQGDIASQPFEEDELISPAFGSPQVTFQPAVLNEPPTEDHLLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACKASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATSSEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVWGECKSSHNPMEHPIRPCSSILDVGSSVTAVSVCPVLNPAQRYIVAIGLESGKICIYSWNKTNQEINDWTSCVETNPSQSHSLGIRRLCWKSCSDDDDDDDDDDTEQSEEGPEWLHFASCGEDHTVKIYRVNRRAL", "length": 831 }, "evidence": [ { "id": "A0AAA9SPU1", "url": "https://omabrowser.org/oma/group/A0AAA9SPU1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" }, { "name": "elongator holoenzyme complex", "id": "GO:0033588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033588", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" }, { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA wobble uridine modification", "id": "GO:0002098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPU1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 239, "end_pos": 241 }, { "start_pos": 346, "end_pos": 348 }, { "start_pos": 708, "end_pos": 710 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SQ97-1", "uniprot_ac": "A0AAA9SQ97", "uniprot_id": "A0AAA9SQ97_BOVIN", "mass": { "chemical_mass": 63108.0, "monoisotopic_mass": 63108.0 }, "refseq": {}, "gene_names": [ { "name": "HIC2", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ] } ], "protein_names": [ { "name": "Hypermethylated in cancer 2 protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SQ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcriptional repressor.", "evidence": [ { "database": "UniProtKB", "id": "E1BDC0", "url": "https://www.uniprot.org/uniprotkb/E1BDC0#function" }, { "database": "UniProtKB", "id": "ARBA00057867", "url": "https://www.uniprot.org/uniprotkb/ARBA00057867#function" }, { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97", "locus": { "chromosome": "17", "start_pos": 72196161, "end_pos": 72179175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005951", "url": "https://www.ensembl.org/id/ENSBTAG00000005951" } ] } } ], "crossref": [ { "id": "A0AAA9SQ97", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SQ97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005951", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005951", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539541", "url": "https://www.ncbi.nlm.nih.gov/gene/539541", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539541", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539541", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TGHNNHY", "url": "https://omabrowser.org/oma/group/TGHNNHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDC0", "url": "https://www.orthodb.org/?gene=E1BDC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC0", "url": "https://www.uniprot.org/uniprotkb/E1BDC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPDMELPSHSKQLLLQLNQQRTQGFLCDVIVMVENAVFRAHKNVLAASSVYFKSLVLHDNLISLDTDMVSSAVFQQILDFIYTGRLLPGEPPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRGGAGLGRHPRSQRLSTASVIQTRYPGLVDGRKGAHAPQELSQAKGSDDELFLGGLSQEGAHGLGRPVCPGSGEAGLGGCSTNGAGGSCEQELGLDLSKKSPPLPPATPGPSLTPDDPAQLSDSQEGSPLSTSAPPVANSASYTELGGALSEPMDLEGADDNPLCLLEGPGGPPPRKSLRHSARKKEWAKKEPAAASPFERRDVAPKGPCPGEEAEGLGDRVPNGLLAGSAAAGRPFGEPPHACKEEDENGKDGSDDSAQSGSEGGPAGAPYVYRQEGFEPVPYGDNLYVCIPCAKGFPSSEQLNAHVETHAEEELLLKEEGGAYETGSAGADEEAEDLSAPSAALAAGPRPFKCSACEKTYKDAATLRQHEKTHWLARPFPCGICGKMFTQRGTMTRHMRSHLGLKPFACGECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTAPS", "length": 594, "header": "tr|A0AAA9SQ97-1|A0AAA9SQ97_BOVIN Isoform 1 of Hypermethylated in cancer 2 protein OS=Bos taurus OX=9913 GN=HIC2 PE=3 SV=1 CANONICAL=A0AAA9SQ97-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97/entry#A0AAA9SQ97-1", "sequence": { "sequence": "MGPDMELPSHSKQLLLQLNQQRTQGFLCDVIVMVENAVFRAHKNVLAASSVYFKSLVLHDNLISLDTDMVSSAVFQQILDFIYTGRLLPGEPPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRGGAGLGRHPRSQRLSTASVIQTRYPGLVDGRKGAHAPQELSQAKGSDDELFLGGLSQEGAHGLGRPVCPGSGEAGLGGCSTNGAGGSCEQELGLDLSKKSPPLPPATPGPSLTPDDPAQLSDSQEGSPLSTSAPPVANSASYTELGGALSEPMDLEGADDNPLCLLEGPGGPPPRKSLRHSARKKEWAKKEPAAASPFERRDVAPKGPCPGEEAEGLGDRVPNGLLAGSAAAGRPFGEPPHACKEEDENGKDGSDDSAQSGSEGGPAGAPYVYRQEGFEPVPYGDNLYVCIPCAKGFPSSEQLNAHVETHAEEELLLKEEGGAYETGSAGADEEAEDLSAPSAALAAGPRPFKCSACEKTYKDAATLRQHEKTHWLARPFPCGICGKMFTQRGTMTRHMRSHLGLKPFACGECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTAPS", "length": 594, "header": "tr|A0AAA9SQ97-1|A0AAA9SQ97_BOVIN Isoform 1 of Hypermethylated in cancer 2 protein OS=Bos taurus OX=9913 GN=HIC2 PE=3 SV=1 CANONICAL=A0AAA9SQ97-1" }, "locus": { "chromosome": "17", "start_pos": 72194699, "end_pos": 72192918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102850.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102850.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085111.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085111.1" } ] } }, { "isoform_ac": "E1BDC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97/entry#E1BDC0-1", "sequence": { "sequence": "MVSGPLALRWCVWAGRGDMGPDMELPSHSKQLLLQLNQQRTQGFLCDVIVMVENAVFRAHKNVLAASSVYFKSLVLHDNLISLDTDMVSSAVFQQILDFIYTGRLLPGEPPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRGGAGLGRHPRSQRLSTASVIQTRYPGLVDGRKGAHAPQELSQAKGSDDELFLGGLSQEGAHGLGRPVCPGSGEAGLGGCSTNGAGGSCEQELGLDLSKKSPPLPPATPGPSLTPDDPAQLSDSQEGSPLSTSAPPVANSASYTELGGALSEPMDLEGADDNPLCLLEGPGGPPPRKSLRHSARKKEWAKKEPAAASPFERRDVAPKGPCPGEEAEGLGDRVPNGLLAGSAAAGRPFGEPPHACKEEDENGKDGSDDSAQSGSEGGPAGAPYVYRQEGFEPVPYGDNLYVCIPCAKGFPSSEQLNAHVETHAEEELLLKEEGGAYETGSAGADEEAEDLSAPSAALAAGPRPFKCSACEKTYKDAATLRQHEKTHWLARPFPCGICGKMFTQRGTMTRHMRSHLGLKPFACGECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTAPS", "length": 612, "header": "tr|E1BDC0-1|E1BDC0_BOVIN Computationally mapped isoform of Hypermethylated in cancer 2 protein OS=Bos taurus OX=9913 GN=HIC2 PE=3 SV=2 CANONICAL=A0AAA9SQ97-1" }, "locus": { "chromosome": "17", "start_pos": 72194699, "end_pos": 72191776, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007809.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007809.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007809.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007809.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 239, "start_aa": "Thr", "end_pos": 239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr239", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539541", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539541", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P7L2-1", "protein_name": "Hypermethylated in cancer 1 protein", "gene_name": "HIC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTVFRQILDFIYTGKLLTTDQPGEQNFSALLTAASYLQLHDLAALCRKKLKRNSKSFAGKASGLGVGRSARSQRLSTASVIQARYSGSNEGLKGSHSKELSKGKLSDDEVFISSSNQENCHSLSRGASKNCGGGGSANGSTGDQELGLDLSKKSPSLPVAASHDDTQHSESQHGSPQSASVPAANSASSFDESGVGASHSIADSSDPMEMDLSEECHHSMTESSQRKGLRHSSRKKEWIKKDNAFDRKDGGKDRDEGEGLPNGILLGPLSKSVERSLAGSYGADLPYSCKEEVENGKENSDDSGQSESESGGHTSANYVYRQEGFEPVAYGDNLYVCIPCGKGFPSSEQLNAHVETHTEEDLYIKEEGTYGGKDEAEDLSNPNQSYSAESRPFKCSVCEKSYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACEECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPT", "length": 570 }, "evidence": [ { "id": "A0AAA9SQ97", "url": "https://omabrowser.org/oma/group/A0AAA9SQ97/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A9X7-1", "protein_name": "Hypermethylated in cancer 2 protein", "gene_name": "Hic2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSGPLALRWCPWAGHRDMGPDMELPSHSKQLLLQLNQQRAKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPGDQPSEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGPGRVGTAGMGRPTRSQRLSTASVIQARYPGLVDGRKGHPAPQELPQAKGSDDELFLGSSTQESTHGLGLGGPAAGEVGLGGCSTSTNGSSGGCEQELGLDLSKKSPPLPPTTPVPHLTPEDPAQLSDSQRESPPPTSTSALPVSNSTSYVELGATPDEPMDLEGAEENHLSLLEGQGGQPRKSLRHSARKKDWNKKEPVAGSPFDRRETGSKSSCPGEEGEAPGDRVPNGVLASSAGGGGPSAPSYGEPPYPCKEEEENGKDVSEDSGQSGSEGGSGHTGGAHYVYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSTPSSTAYAAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS", "length": 622 }, "evidence": [ { "id": "A0AAA9SQ97", "url": "https://omabrowser.org/oma/group/A0AAA9SQ97/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96JB3-1", "protein_name": "Hypermethylated in cancer 2 protein", "gene_name": "HIC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS", "length": 615 }, "evidence": [ { "id": "A0AAA9SQ97", "url": "https://omabrowser.org/oma/group/A0AAA9SQ97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JLZ6-1", "protein_name": "Hypermethylated in cancer 2 protein", "gene_name": "Hic2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSGPLALRWCPWAGHRDMGPDMELPSHSKQLLLQLNQQRAKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPSEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGPGRVGTAGIGRPTRSQRLSTASVIQARFPGLVDVRKGHPAPQELPQAKGSDDELFLGTSTQESTHGLGLGGPAGGEMGLGGCSTSTNGSSGGCEQELGLDLSKKSPPLPPTTPGPHLTPEDPAQLSDSQRESPAPTSTSALPVGNSASFVELGATPEEPMDVEGAEENHLSLLEGQGGQPRKSLRHSARKKDWNKKEPVAGSPFDRRETGSKGSCPGEEGEGTGDRVPNGVLASSAGGGGPSASYGEQSFPCKEEEENGKDGSEDSGQSGSEGGSGHTGAHYVYRQEGYETVSYGDNVYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSTPSAAYTADSRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS", "length": 619 }, "evidence": [ { "id": "A0AAA9SQ97", "url": "https://omabrowser.org/oma/group/A0AAA9SQ97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQ97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SQ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 91, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SQ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ97" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 420, "end_pos": 447, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 239 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SRP0-1", "uniprot_ac": "A0AAA9SRP0", "uniprot_id": "A0AAA9SRP0_BOVIN", "mass": { "chemical_mass": 67038.0, "monoisotopic_mass": 67038.0 }, "refseq": {}, "gene_names": [ { "name": "ASH2L", "type": "recommended", "evidence": [ { "id": "A0AAA9SRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ] } ], "protein_names": [ { "name": "Set1/Ash2 histone methyltransferase complex subunit ASH2", "type": "recommended", "evidence": [ { "id": "A0AAA9SRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0/entry#names_and_taxonomy" } ] }, { "name": "ASH2-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May play a role in hematopoiesis. In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.", "evidence": [ { "database": "UniProtKB", "id": "E1BEP4", "url": "https://www.uniprot.org/uniprotkb/E1BEP4#function" }, { "database": "UniProtKB", "id": "ARBA00056054", "url": "https://www.uniprot.org/uniprotkb/ARBA00056054#function" }, { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASH2L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0", "locus": { "chromosome": "27", "start_pos": 33311648, "end_pos": 33285825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000978", "url": "https://www.ensembl.org/id/ENSBTAG00000000978" } ] } } ], "crossref": [ { "id": "A0AAA9SRP0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SRP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000978", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000978", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12872", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12872", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15583", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15583", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BEP4", "url": "https://www.orthodb.org/?gene=E1BEP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10598", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10598", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10598:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10598:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214841", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8936459", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936459", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9772755", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9818564", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9818564", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9909649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEP4", "url": "https://www.uniprot.org/uniprotkb/E1BEP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEP4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAGSGPGLGVSAGPGPAAAANATPAEEGETKQAAAVAAAPAGEGTSAAPASAEPGSGEAESGDANSVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGSTAGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVRTLCSSCEHGSREIGEPLWSESHELGSRRTCERPRSEQAA", "length": 615, "header": "tr|A0AAA9SRP0-1|A0AAA9SRP0_BOVIN Isoform 1 of Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Bos taurus OX=9913 GN=ASH2L PE=4 SV=2 CANONICAL=A0AAA9SRP0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0/entry#A0AAA9SRP0-1", "sequence": { "sequence": "MAAAGSGPGLGVSAGPGPAAAANATPAEEGETKQAAAVAAAPAGEGTSAAPASAEPGSGEAESGDANSVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGSTAGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVRTLCSSCEHGSREIGEPLWSESHELGSRRTCERPRSEQAA", "length": 615, "header": "tr|A0AAA9SRP0-1|A0AAA9SRP0_BOVIN Isoform 1 of Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Bos taurus OX=9913 GN=ASH2L PE=4 SV=2 CANONICAL=A0AAA9SRP0-1" }, "locus": { "chromosome": "27", "start_pos": 33310196, "end_pos": 33285833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112007.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112007.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089048.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089048.2" } ] } }, { "isoform_ac": "E1BEP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0/entry#E1BEP4-1", "sequence": { "sequence": "MAAAGSGPGLGVSAGPGPAAAANATPAEEGETKQAAAVAAAPAGEGTSAAPASAEPGSGEAESGDANSVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGSTAGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVFTTFFPFFTSAWIEFVPGLHKLWTMLQVPSKGSHVPPYE", "length": 614, "header": "tr|E1BEP4-1|E1BEP4_BOVIN Computationally mapped isoform of Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Bos taurus OX=9913 GN=ASH2L PE=4 SV=2 CANONICAL=A0AAA9SRP0-1" }, "locus": { "chromosome": "27", "start_pos": 33310922, "end_pos": 33285833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001294.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001294.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001294.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001294.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-201722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "resource": "Reactome", "description": "Formation of the beta-catenin:TCF transactivating complex" }, { "id": "R-BTA-3214841", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214841", "resource": "Reactome", "description": "PKMTs methylate histone lysines" }, { "id": "R-BTA-8936459", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8936459", "resource": "Reactome", "description": "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" }, { "id": "R-BTA-9772755", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "resource": "Reactome", "description": "Formation of WDR5-containing histone-modifying complexes" }, { "id": "R-BTA-9818564", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9818564", "resource": "Reactome", "description": "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes" }, { "id": "R-BTA-9909649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909649", "resource": "Reactome", "description": "Regulation of PD-L1(CD274) transcription" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "MLL3/4 complex", "id": "GO:0044666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044666", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "Set1C/COMPASS complex", "id": "GO:0048188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048188", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "MLL1 complex", "id": "GO:0071339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "transcription initiation-coupled chromatin remodeling", "id": "GO:0045815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "response to estrogen", "id": "GO:0043627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043627", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SRP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP0" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 361, "end_pos": 549, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 23, "end_pos": 25 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STQ6-1", "uniprot_ac": "A0AAA9STQ6", "uniprot_id": "A0AAA9STQ6_BOVIN", "mass": { "chemical_mass": 56460.0, "monoisotopic_mass": 56460.0 }, "refseq": { "ac": "XP_005209702", "name": "ras GTPase-activating protein-binding protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209702" }, "gene_names": [ { "name": "G3BP1", "type": "recommended", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "name": "G3BP1", "type": "synonym", "evidence": [ { "id": "XP_005209702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209702" } ] }, { "name": "G3BP", "type": "synonym", "evidence": [ { "id": "XP_005209702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209702" } ] } ], "protein_names": [ { "name": "Ras GTPase-activating protein-binding protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.12", "type": "synonym", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6/entry#names_and_taxonomy" } ] }, { "name": "ras GTPase-activating protein-binding protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209702" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "G3BP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6", "locus": { "chromosome": "7", "start_pos": 63001442, "end_pos": 62972678, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020309", "url": "https://www.ensembl.org/id/ENSBTAG00000020309" } ] } } ], "crossref": [ { "id": "A0AAA9STQ6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STQ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00780", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00780", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12463", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12463", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534214", "url": "https://www.ncbi.nlm.nih.gov/gene/534214", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10693", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10693", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10693:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10693:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02136", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02136", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209702", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209702", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIITNIFLSPHYVPGTVRSNLCVSSLLLKRPDEVELTKAMVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFITEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQTVSNDLEEHLEEPVAEPEPEPEPEPEQEPVSEVQEEKSEPVLEETAPEDVQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPLQRPQRDQRVREQRINVPPQRGPRPVREAGEQGDVEPRRIVRHPDSHQLFIGNLPHEVDKSELKDFFQNYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRSIAPRQ", "length": 504, "header": "tr|A0AAA9STQ6-1|A0AAA9STQ6_BOVIN Isoform 1 of Ras GTPase-activating protein-binding protein 1 OS=Bos taurus OX=9913 GN=G3BP1 PE=4 SV=1 CANONICAL=A0AAA9STQ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6/entry#A0AAA9STQ6-1", "sequence": { "sequence": "MIITNIFLSPHYVPGTVRSNLCVSSLLLKRPDEVELTKAMVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFITEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQTVSNDLEEHLEEPVAEPEPEPEPEPEQEPVSEVQEEKSEPVLEETAPEDVQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPLQRPQRDQRVREQRINVPPQRGPRPVREAGEQGDVEPRRIVRHPDSHQLFIGNLPHEVDKSELKDFFQNYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRSIAPRQ", "length": 504, "header": "tr|A0AAA9STQ6-1|A0AAA9STQ6_BOVIN Isoform 1 of Ras GTPase-activating protein-binding protein 1 OS=Bos taurus OX=9913 GN=G3BP1 PE=4 SV=1 CANONICAL=A0AAA9STQ6-1" }, "locus": { "chromosome": "7", "start_pos": 63001309, "end_pos": 62973474, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125313.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125313.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088729.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088729.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "DNA/RNA helicase activity", "id": "GO:0033677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "endonuclease activity", "id": "GO:0004519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004519", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "molecular condensate scaffold activity", "id": "GO:0140693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] } ] }, { "uniprot_ac": "Q3SZ65", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ] } ] }, { "uniprot_ac": "Q3T084", "gene_name": "CCT6B", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T084" } ] } ] }, { "uniprot_ac": "Q3T0K2", "gene_name": "CCT3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3T0K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ] } ] }, { "uniprot_ac": "Q3T147", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3T147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T147" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZBH9", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3ZBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH9" } ] } ] }, { "uniprot_ac": "Q3ZBT1", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q3ZBT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT1" } ] } ] }, { "uniprot_ac": "Q3ZBV2", "gene_name": "DDX19A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3ZBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV2" } ] } ] }, { "uniprot_ac": "Q3ZC07", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3ZC07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC07" } ] } ] }, { "uniprot_ac": "Q3ZC91", "gene_name": "SMPDL3A", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3ZC91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC91" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q59HJ6", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q59HJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q5W5U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5W5U4" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] }, { "uniprot_ac": "Q95M18", "gene_name": "HSP90B1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q95M18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95M18" } ] } ] }, { "uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" }, { "id": "PS50177", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50177" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTF2", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 172, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 378, "end_pos": 453, "start_aa": "His", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.4.12", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12" } ] }, { "ec_number": "3.6.4.13", "ec_name": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "3.6.4.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13" }, { "id": "3.6.4.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.13" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST33-1", "uniprot_ac": "A0AAA9ST33", "uniprot_id": "A0AAA9ST33_BOVIN", "mass": { "chemical_mass": 94706.0, "monoisotopic_mass": 94706.0 }, "refseq": {}, "gene_names": [ { "name": "EXOC6B", "type": "recommended", "evidence": [ { "id": "A0AAA9ST33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ] } ], "protein_names": [ { "name": "Exocyst complex component", "type": "recommended", "evidence": [ { "id": "A0AAA9ST33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NAX8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAX8#function" }, { "database": "UniProtKB", "id": "PIRNR025007", "url": "https://www.uniprot.org/uniprotkb/PIRNR025007#function" }, { "database": "UniProtKB", "id": "A0AAA9T6J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J0#function" }, { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33#function" }, { "database": "UniProtKB", "id": "A0AAA9T6L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L6#function" }, { "database": "UniProtKB", "id": "A0A3Q1MM70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM70#function" }, { "database": "UniProtKB", "id": "A0A3Q1MTU5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTU5#function" }, { "database": "UniProtKB", "id": "F1MIR2", "url": "https://www.uniprot.org/uniprotkb/F1MIR2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXOC6B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33", "locus": { "chromosome": "11", "start_pos": 12345333, "end_pos": 11625844, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020799", "url": "https://www.ensembl.org/id/ENSBTAG00000020799" } ] } } ], "crossref": [ { "id": "A0AAA9ST33", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST33", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020799", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616280", "url": "https://www.ncbi.nlm.nih.gov/gene/616280", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM70", "url": "https://www.orthodb.org/?gene=A0A3Q1MM70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTU5", "url": "https://www.orthodb.org/?gene=A0A3Q1MTU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NAX8", "url": "https://www.orthodb.org/?gene=A0A3Q1NAX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MIR2", "url": "https://www.orthodb.org/?gene=F1MIR2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12702", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12702", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12702:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12702:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MM70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTU5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAX8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAX8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIR2", "url": "https://www.uniprot.org/uniprotkb/F1MIR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIR2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPTCKYLRVNPVTALTLLEKISREMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "length": 815, "header": "tr|A0AAA9ST33-1|A0AAA9ST33_BOVIN Isoform 1 of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=1 CANONICAL=A0AAA9ST33-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MM70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#A0A3Q1MM70-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPTCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "length": 751, "header": "tr|A0A3Q1MM70-1|A0A3Q1MM70_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=1 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12344329, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075601.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075601.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072861.1" } ] } }, { "isoform_ac": "A0A3Q1MTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#A0A3Q1MTU5-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQEETHSRAWWTKEHHQNPFLSMN", "length": 754, "header": "tr|A0A3Q1MTU5-1|A0A3Q1MTU5_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=2 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12307375, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069705.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069705.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073820.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073820.2" } ] } }, { "isoform_ac": "A0A3Q1NAX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#A0A3Q1NAX8-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPTCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "length": 811, "header": "tr|A0A3Q1NAX8-1|A0AAA9ST33_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=2 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12344329, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072515.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072515.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068418.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068418.2" } ] } }, { "isoform_ac": "A0AAA9ST33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#A0AAA9ST33-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPTCKYLRVNPVTALTLLEKISREMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "length": 815, "header": "tr|A0AAA9ST33-1|A0AAA9ST33_BOVIN Isoform 1 of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=1 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12344329, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121207.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121207.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089577.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089577.1" } ] } }, { "isoform_ac": "A0AAA9T6J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#A0AAA9T6J0-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQRLLSQLAFLGKQKLNFIGKTHPRKKFSLLTVHEKEVW", "length": 769, "header": "tr|A0AAA9T6J0-1|A0AAA9T6J0_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=1 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12185704, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112974.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112974.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093506.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093506.1" } ] } }, { "isoform_ac": "A0AAA9T6L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#A0AAA9T6L6-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPTCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "length": 755, "header": "tr|A0AAA9T6L6-1|A0AAA9T6L6_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=1 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12344329, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125852.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125852.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092387.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092387.1" } ] } }, { "isoform_ac": "F1MIR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33/entry#F1MIR2-1", "sequence": { "sequence": "MERVKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLREQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIILQQPRIGSKRKSKKEAYTIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWSGIFRNILDSDNYSPIPVTSEEMYKKVIGQFPFQDAELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTEDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGSKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPTCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS", "length": 766, "header": "tr|F1MIR2-1|F1MIR2_BOVIN Computationally mapped isoform of Exocyst complex component OS=Bos taurus OX=9913 GN=EXOC6B PE=3 SV=3 CANONICAL=A0AAA9ST33-1" }, "locus": { "chromosome": "11", "start_pos": 12344329, "end_pos": 11625912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047228.6", "url": "https://www.ensembl.org/id/ENSBTAT00000047228.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044448.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044448.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "pmid": "" }, { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "pmid": "" }, { "name": "vesicle tethering involved in exocytosis", "id": "GO:0090522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090522", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 562, "end_pos": 564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 579, "end_pos": 581, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" }, { "id": "PF20651", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20651" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Exocyst complex component EXOC6/Sec15 N-terminal", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 221, "start_aa": "Lys", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9ST33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST33" }, { "id": "PF04091", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04091" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Exocyst complex subunit EXOC6/Sec15 C-terminal", "eco_id": "ECO_0000259", "start_pos": 421, "end_pos": 770, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 562, "end_pos": 564 }, { "start_pos": 579, "end_pos": 581 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STW6-1", "uniprot_ac": "A0AAA9STW6", "uniprot_id": "A0AAA9STW6_BOVIN", "mass": { "chemical_mass": 41746.0, "monoisotopic_mass": 41746.0 }, "refseq": { "ac": "XP_005225981", "name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225981" }, "gene_names": [ { "name": "AGPAT5", "type": "recommended", "evidence": [ { "id": "A0AAA9STW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ] }, { "name": "AGPAT5", "type": "synonym", "evidence": [ { "id": "XP_005225981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225981" } ] } ], "protein_names": [ { "name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225981" } ] }, { "name": "1-acylglycerol-3-phosphate O-acyltransferase 5", "type": "synonym", "evidence": [ { "id": "A0AAA9STW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AGPAT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6", "locus": { "chromosome": "27", "start_pos": 5857712, "end_pos": 5810258, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004922", "url": "https://www.ensembl.org/id/ENSBTAG00000004922" } ] } } ], "crossref": [ { "id": "A0AAA9STW6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07990", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07990", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530414", "url": "https://www.ncbi.nlm.nih.gov/gene/530414", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HRSTVDW", "url": "https://omabrowser.org/oma/group/HRSTVDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10983:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10983:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01553", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01553", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225981", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225981", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPU2", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLSLVLHMHSVRCVLPAAVLLGTAPTYVLVWGAWRLLSALLPSRFYQAVDDRLYCVYQSMVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIIADILAVRQSALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNENQMRKKLQRYINAGTPMYLVIFPEGTRYNPELTKVISASQAFAAQEGLPVLKHVLTPRIKATHVAFDSMKDYLDAVYDVTVAFEGSVDDKGQRKEAPSMAEFLCKECPKIHIHIDRIDKKNIPEEQVSMKRWLHERFEIKDKLLIEFYDSPDPERRNKFPGESVNSKLSLKKTLPSFLILSGLTAGLLMTEAGRKLYVKTWIYGTLIGCLWVSIKA", "length": 365, "header": "tr|A0AAA9STW6-1|A0AAA9STW6_BOVIN Isoform 1 of 1-acylglycerol-3-phosphate O-acyltransferase 5 OS=Bos taurus OX=9913 GN=AGPAT5 PE=3 SV=2 CANONICAL=A0AAA9STW6-1" }, "isoforms": [ { "isoform_ac": "A0A3S5ZPU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6/entry#A0A3S5ZPU2-1", "sequence": { "sequence": "MLLSLVLHMHSVRCVLPAAVLLGTAPTYVLVWGAWRLLSALLPSRFYQAVDDRLYCVYQSMVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIIADILAVRQSALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNENQMRKKLQRYINAGTPMYLVIFPEGTRYNPELTKVISASQAFAAQEGLPVLKHVLTPRIKATHVAFDSMKDYLDAVYDVTVAFEGSVDDKGQRKEAPSMAEFLCKECPKIHIHIDRIDKKNIPEEQVSMKRWLHERFEIKDKLLIEFYDSPDPERRNKFPGESVNSKLSLKKTLPSFLILSGLTAGLLMTEAGRKLYVKTWIYGTLIGCLWIISRGAAHSGHGASPEALCPDAGLTRKCCVLTQASTV", "length": 397, "header": "tr|A0A3S5ZPU2-1|A0AAA9STW6_BOVIN Computationally mapped isoform of 1-acylglycerol-3-phosphate O-acyltransferase 5 OS=Bos taurus OX=9913 GN=AGPAT5 PE=3 SV=1 CANONICAL=A0AAA9STW6-1" }, "locus": { "chromosome": "27", "start_pos": 5856708, "end_pos": 5810387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006476.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006476.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006476.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006476.6" } ] } }, { "isoform_ac": "A0AAA9STW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6/entry#A0AAA9STW6-1", "sequence": { "sequence": "MLLSLVLHMHSVRCVLPAAVLLGTAPTYVLVWGAWRLLSALLPSRFYQAVDDRLYCVYQSMVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIIADILAVRQSALGHVRYVLKDGLKWLPLYGCYFSQHGGIYVKRSAKFNENQMRKKLQRYINAGTPMYLVIFPEGTRYNPELTKVISASQAFAAQEGLPVLKHVLTPRIKATHVAFDSMKDYLDAVYDVTVAFEGSVDDKGQRKEAPSMAEFLCKECPKIHIHIDRIDKKNIPEEQVSMKRWLHERFEIKDKLLIEFYDSPDPERRNKFPGESVNSKLSLKKTLPSFLILSGLTAGLLMTEAGRKLYVKTWIYGTLIGCLWVSIKA", "length": 365, "header": "tr|A0AAA9STW6-1|A0AAA9STW6_BOVIN Isoform 1 of 1-acylglycerol-3-phosphate O-acyltransferase 5 OS=Bos taurus OX=9913 GN=AGPAT5 PE=3 SV=2 CANONICAL=A0AAA9STW6-1" }, "locus": { "chromosome": "27", "start_pos": 5855568, "end_pos": 5810387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087555.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087555.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088785.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088785.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1483166", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "resource": "Reactome", "description": "Synthesis of PA" } ], "orthologs": [ { "uniprot_canonical_ac": "F1QDN6-1", "protein_name": "2.3.1.51", "gene_name": "agpat5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLLSLVVHTYSLRYWLPTAVMLGTAPAYLLSWSVWRLLSAILPARLYHTVDDRAYSVYQSMVLFFFENYTGVEIVIYGEIPKKKENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNPELKKVISDSQAFAAKQGLAVLNHILTPRMKASHVAIETMREHLDAVYDITVAYEGTLTADGQRRPAPTMPEFLCKECPRVHIHISRVDIKDIPAEPDVFRGWLHQRFEIKDKLLTTFYESEDPAKKSRFPGEGRKSPLSLSKTLPSLLILSGLTFPMLLTESGRKLYLNTWLYGTLIGWIWVGLSP", "length": 365 }, "evidence": [ { "id": "A0AAA9STW6", "url": "https://omabrowser.org/oma/group/A0AAA9STW6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D1E8-1", "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon", "gene_name": "Agpat5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLSLVLHTYSMRYLLPSVLLLGSAPTYLLAWTLWRVLSALMPARLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVADMLAARQDALGHVRYVLKDKLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYVNAGTPMYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSMKSHLDAIYDVTVVYEGNEKGSGKYSNPPSMTEFLCKQCPKLHIHFDRIDRNEVPEEQEHMKKWLHERFEIKDRLLIEFYDSPDPERRNKFPGKSVHSRLSVKKTLPSVLILGSLTAVMLMTESGRKLYMGTWLYGTLLGCLWFVIKA", "length": 365 }, "evidence": [ { "id": "A0AAA9STW6", "url": "https://omabrowser.org/oma/group/A0AAA9STW6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LHN4-1", "protein_name": "Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5", "gene_name": "LPAT5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEKKSVPNSDKLSLIRVLRGIICLMVLVSTAFMMLIFWGFLSAVVLRLFSIRYSRKCVSFFFGSWLALWPFLFEKINKTKVIFSGDKVPCEDRVLLIANHRTEVDWMYFWDLALRKGQIGNIKYVLKSSLMKLPLFGWAFHLFEFIPVERRWEVDEANLRQIVSSFKDPRDALWLALFPEGTDYTEAKCQRSKKFAAENGLPILNNVLLPRTKGFVSCLQELSCSLDAVYDVTIGYKTRCPSFLDNVYGIEPSEVHIHIRRINLTQIPNQEKDINAWLMNTFQLKDQLLNDFYSNGHFPNEGTEKEFNTKKYLINCLAVIAFTTICTHLTFFSSMIWFRIYVSLACVYLTSATHFNLRSVPLVETAKNSLKLVNK", "length": 375 }, "evidence": [ { "id": "A0AAA9STW6", "url": "https://omabrowser.org/oma/group/A0AAA9STW6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NUQ2-1", "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon", "gene_name": "AGPAT5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLSLVLHTYSMRYLLPSVVLLGTAPTYVLAWGVWRLLSAFLPARFYQALDDRLYCVYQSMVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVVYEGKDDGGQRRESPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYESPDPERRKRFPGKSVNSKLSIKKTLPSMLILSGLTAGMLMTDAGRKLYVNTWIYGTLLGCLWVTIKA", "length": 364 }, "evidence": [ { "id": "A0AAA9STW6", "url": "https://omabrowser.org/oma/group/A0AAA9STW6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "1-acylglycerol-3-phosphate O-acyltransferase activity", "id": "GO:0003841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003841", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" }, { "name": "phosphatidylinositol acyl-chain remodeling", "id": "GO:0036149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STW6" }, { "id": "SM00563", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00563" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phospholipid/glycerol acyltransferase", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 212, "start_aa": "Ile", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSI2-1", "uniprot_ac": "A0AAA9SSI2", "uniprot_id": "A0AAA9SSI2_BOVIN", "mass": { "chemical_mass": 55298.0, "monoisotopic_mass": 55298.0 }, "refseq": {}, "gene_names": [ { "name": "CHST13", "type": "recommended", "evidence": [ { "id": "A0AAA9SSI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ] } ], "protein_names": [ { "name": "Carbohydrate sulfotransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SSI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "A0AAA9SSI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2", "locus": { "chromosome": "22", "start_pos": 60452324, "end_pos": 60460114, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008778", "url": "https://www.ensembl.org/id/ENSBTAG00000008778" } ] } } ], "crossref": [ { "id": "A0AAA9SSI2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137:SF60", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137:SF60", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SL64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVLGVGGGRRPGQRAEAGETATATGLLRRSPPFAPWAAAHCPAGRGRGRADWTSPPPTSAPARLQTAKPLHRRASGVEWCTRRRDGPGSGSKCGPGARIPDGPGFRVRSEHEPVGGSRGGTEVVPRVPLQRGPHWARPSAARSGRAWRAPAGGGARWRPRVWVPCSCSWAPRSAPCARRSRATLWAQAGLAGRGEAPCRRSTTWTSRAPSVALSPQGPRSALAEVHRQRRELLHRACSRHTRRQRLLRPEDLRHVLVDDARGLLYCYVPKVACTNWKRVLLALNGRGSGDPRAIPAPDAHAPGRLPSLADFSPAEVNRRLRTYLAFLFVREPFERLASAYRNKLQRPWGAAFQRRFGTDIVRRLRPHPSPDALARGHDVRFAEFLAYLLDPRTRREGPLNEHWERAHALCHPCRLRYDVVGKFETLAEDAAFVLGLAGAPGLRFPEPPPGARAAARDRAERLFRDISPFYQRRLFGLYKMDFLLFNYSVPSYLRLR", "length": 497, "header": "tr|A0AAA9SSI2-1|A0AAA9SSI2_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST13 PE=3 SV=1 CANONICAL=A0AAA9SSI2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2/entry#A0AAA9SL64-1", "sequence": { "sequence": "VEILTRSVGPTERSRATLWAQAGLAGRGEAPCRRSTTWTSRAPSVALSPQGPRSALAEVHRQRRELLHRACSRHTRRQRLLRPEDLRHVLVDDARGLLYCYVPKVACTNWKRVLLALNGRGSGDPRAIPAPDAHAPGRLPSLADFSPAEVNRRLRTYLAFLFVREPFERLASAYRNKLQRPWGAAFQRRFGTDIVRRLRPHPSPDALARGHDVRFAEFLAYLLDPRTRREGPLNEHWERAHALCHPCRLRYDVVGKFETLAEDAAFVLGLAGAPGLRFPEPPPGARAAARDRAERLFRDISPFYQRRLFGLYKMDFLLFNYSVPSYLRLR", "length": 330, "header": "tr|A0AAA9SL64-1|A0AAA9SSI2_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST13 PE=3 SV=1 CANONICAL=A0AAA9SSI2-1" }, "locus": { "chromosome": "22", "start_pos": 60458199, "end_pos": 60453165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115300.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115300.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084649.1" } ] } }, { "isoform_ac": "A0AAA9SSI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2/entry#A0AAA9SSI2-1", "sequence": { "sequence": "MRVLGVGGGRRPGQRAEAGETATATGLLRRSPPFAPWAAAHCPAGRGRGRADWTSPPPTSAPARLQTAKPLHRRASGVEWCTRRRDGPGSGSKCGPGARIPDGPGFRVRSEHEPVGGSRGGTEVVPRVPLQRGPHWARPSAARSGRAWRAPAGGGARWRPRVWVPCSCSWAPRSAPCARRSRATLWAQAGLAGRGEAPCRRSTTWTSRAPSVALSPQGPRSALAEVHRQRRELLHRACSRHTRRQRLLRPEDLRHVLVDDARGLLYCYVPKVACTNWKRVLLALNGRGSGDPRAIPAPDAHAPGRLPSLADFSPAEVNRRLRTYLAFLFVREPFERLASAYRNKLQRPWGAAFQRRFGTDIVRRLRPHPSPDALARGHDVRFAEFLAYLLDPRTRREGPLNEHWERAHALCHPCRLRYDVVGKFETLAEDAAFVLGLAGAPGLRFPEPPPGARAAARDRAERLFRDISPFYQRRLFGLYKMDFLLFNYSVPSYLRLR", "length": 497, "header": "tr|A0AAA9SSI2-1|A0AAA9SSI2_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST13 PE=3 SV=1 CANONICAL=A0AAA9SSI2-1" }, "locus": { "chromosome": "22", "start_pos": 60459915, "end_pos": 60453165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129452.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129452.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086950.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086950.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "pmid": "" }, { "name": "dermatan 4-sulfotransferase activity", "id": "GO:0001537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "pmid": "" }, { "name": "chondroitin 4-sulfotransferase activity", "id": "GO:0047756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate biosynthetic process", "id": "GO:0016051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "pmid": "" }, { "name": "chondroitin sulfate proteoglycan biosynthetic process", "id": "GO:0050650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 487, "end_pos": 489 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST10-1", "uniprot_ac": "A0AAA9ST10", "uniprot_id": "A0AAA9ST10_BOVIN", "mass": { "chemical_mass": 75749.0, "monoisotopic_mass": 75749.0 }, "refseq": { "ac": "XP_059735825", "name": "PX domain-containing protein kinase-like protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735825" }, "gene_names": [ { "name": "PXK", "type": "recommended", "evidence": [ { "id": "A0AAA9ST10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ] }, { "name": "PXK", "type": "synonym", "evidence": [ { "id": "XP_059735825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735825" } ] } ], "protein_names": [ { "name": "PX domain-containing protein kinase-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9ST10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#names_and_taxonomy" } ] }, { "name": "Modulator of Na,K-ATPase", "type": "synonym", "evidence": [ { "id": "A0AAA9ST10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#names_and_taxonomy" } ] }, { "name": "PX domain-containing protein kinase-like protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059735825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735825" } ] } ], "function": [ { "annotation": "Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LIQ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIQ3#function" }, { "database": "UniProtKB", "id": "ARBA00054468", "url": "https://www.uniprot.org/uniprotkb/ARBA00054468#function" }, { "database": "UniProtKB", "id": "A0AAA9S1C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C2#function" }, { "database": "UniProtKB", "id": "A0AAA9S178", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S178#function" }, { "database": "UniProtKB", "id": "F6Q244", "url": "https://www.uniprot.org/uniprotkb/F6Q244#function" }, { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PXK", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10", "locus": { "chromosome": "22", "start_pos": 42924248, "end_pos": 43005784, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019989", "url": "https://www.ensembl.org/id/ENSBTAG00000019989" } ] } } ], "crossref": [ { "id": "A0AAA9ST10", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019989", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019989", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06871", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06871", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614093", "url": "https://www.ncbi.nlm.nih.gov/gene/614093", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6Q244", "url": "https://www.orthodb.org/?gene=F6Q244", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22999", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22999", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22999:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22999:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059735825", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735825", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIQ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S178", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S178", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S178-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S178-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q244", "url": "https://www.uniprot.org/uniprotkb/F6Q244", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q244-1", "url": "https://www.uniprot.org/uniprotkb/F6Q244-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFMEKLPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTAGPHRWYRHATVPMGSAPPMLGKMEKLYTQKQDWELIVAHIVNSLLRNSDKLKKVEKLDLNQVLYNFTVEVRNRCKGLDLIDRVPEKLWTEVRDIIQAAMIKTIPNKKKCKKAKWLSEEALQIAEKRRKAKGKGEKGKIHPSECRLPKSSRKR", "length": 661, "header": "tr|A0AAA9ST10-1|A0AAA9ST10_BOVIN Isoform 1 of PX domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=PXK PE=3 SV=1 CANONICAL=A0AAA9ST10-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#A0A3Q1LIQ3-1", "sequence": { "sequence": "MAFMEKLPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSGMSALPPPPPPPPPPAAAPSPPSSTEAPSQFPPQAVNGVSRGALLSSIQNFQKGTLRKAETCDHSAPKIG", "length": 558, "header": "tr|A0A3Q1LIQ3-1|A0AAA9ST10_BOVIN Computationally mapped isoform of PX domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=PXK PE=3 SV=1 CANONICAL=A0AAA9ST10-1" }, "locus": { "chromosome": "22", "start_pos": 43005745, "end_pos": 42925327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082711.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082711.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058998.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058998.2" } ] } }, { "isoform_ac": "A0AAA9S178-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#A0AAA9S178-1", "sequence": { "sequence": "MLMQTFWTSRLLREYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTAGMSALPPPPPPPPPPAAAPSPPSSTEAPSQFPPQAVNGVSRGALLSSIQNFQKGTLRKAETCDHSAPKIG", "length": 558, "header": "tr|A0AAA9S178-1|A0AAA9ST10_BOVIN Computationally mapped isoform of PX domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=PXK PE=3 SV=1 CANONICAL=A0AAA9ST10-1" }, "locus": { "chromosome": "22", "start_pos": 43003567, "end_pos": 42925327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102471.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102471.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078732.1" } ] } }, { "isoform_ac": "A0AAA9S1C2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#A0AAA9S1C2-1", "sequence": { "sequence": "MAFMEKLPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTAVEHAPF", "length": 515, "header": "tr|A0AAA9S1C2-1|A0AAA9ST10_BOVIN Computationally mapped isoform of PX domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=PXK PE=3 SV=1 CANONICAL=A0AAA9ST10-1" }, "locus": { "chromosome": "22", "start_pos": 43005745, "end_pos": 42929646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102676.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102676.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075884.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075884.1" } ] } }, { "isoform_ac": "A0AAA9ST10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#A0AAA9ST10-1", "sequence": { "sequence": "MAFMEKLPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTAGPHRWYRHATVPMGSAPPMLGKMEKLYTQKQDWELIVAHIVNSLLRNSDKLKKVEKLDLNQVLYNFTVEVRNRCKGLDLIDRVPEKLWTEVRDIIQAAMIKTIPNKKKCKKAKWLSEEALQIAEKRRKAKGKGEKGKIHPSECRLPKSSRKR", "length": 661, "header": "tr|A0AAA9ST10-1|A0AAA9ST10_BOVIN Isoform 1 of PX domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=PXK PE=3 SV=1 CANONICAL=A0AAA9ST10-1" }, "locus": { "chromosome": "22", "start_pos": 43005745, "end_pos": 42935340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108354.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108354.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087128.1" } ] } }, { "isoform_ac": "A0AAA9SVB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#A0AAA9SVB3-1", "sequence": { "sequence": "MAFMEKLPAGKVLLDDTVPLTAAIEASQSLQSHTIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTAVEHAPF", "length": 482, "header": "tr|A0AAA9SVB3-1|A0AAA9SVB3_BOVIN Computationally mapped isoform of PX domain containing serine/threonine kinase like OS=Bos taurus OX=9913 GN=PXK PE=4 SV=1 CANONICAL=A0AAA9ST10-1" }, "locus": { "chromosome": "22", "start_pos": 43005745, "end_pos": 42929646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087930.1" } ] } }, { "isoform_ac": "F6Q244-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10/entry#F6Q244-1", "sequence": { "sequence": "MAFMEKLPAGKVLLDDTVPLTAAIEASQSLQSHTIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQHVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKVQGLELQQIKTYGRQVLEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENNEEHSAKYSNSNNSGSGASSPLTSPSSPTPPSTAAALGLGKRCKGRDVRVTSTSSTSTSTSSSSLTSFEHRGALTVSTPGCEWREPRGLTQLHPEFPKRNFEESRNL", "length": 564, "header": "tr|F6Q244-1|F6Q244_BOVIN Computationally mapped isoform of PX domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=PXK PE=3 SV=2 CANONICAL=A0AAA9ST10-1" }, "locus": { "chromosome": "22", "start_pos": 43005745, "end_pos": 42925352, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030715.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030715.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030687.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030687.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 504, "start_aa": "Thr", "end_pos": 504, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr504", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 574, "end_pos": 576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 126, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9ST10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST10" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 481, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 504 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 127, "end_pos": 129 }, { "start_pos": 218, "end_pos": 220 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 574, "end_pos": 576 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STK6-1", "uniprot_ac": "A0AAA9STK6", "uniprot_id": "A0AAA9STK6_BOVIN", "mass": { "chemical_mass": 83411.0, "monoisotopic_mass": 83411.0 }, "refseq": {}, "gene_names": [ { "name": "SPATA7", "type": "recommended", "evidence": [ { "id": "A0AAA9STK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ] } ], "protein_names": [ { "name": "Spermatosis associated 7", "type": "synonym", "evidence": [ { "id": "A0AAA9STK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6", "locus": { "chromosome": "10", "start_pos": 100157580, "end_pos": 100118998, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030456", "url": "https://www.ensembl.org/id/ENSBTAG00000030456" } ] } } ], "crossref": [ { "id": "A0AAA9STK6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STK6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJA0", "url": "https://www.orthodb.org/?gene=A0A3Q1LJA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MV04", "url": "https://www.orthodb.org/?gene=A0A3Q1MV04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14917", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14917", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14917:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14917:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15244", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15244", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LJA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV04", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV04-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NED9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NED9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NED9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NED9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N521", "url": "https://www.uniprot.org/uniprotkb/F1N521", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N521-1", "url": "https://www.uniprot.org/uniprotkb/F1N521-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPACLPARPAATRPAGCWGRSPDGQQSRRAAGRRCTPASQLPPLPSRDRGDRAAGARPCAVTSQSGASGPSLSRPPRVSLRPPPPLRRAAPPSGCLSPNLCRGEPARPLEGPKGTPQVPAVWPQESPSMDASRRGKGPPSRAPAGCPAPSGVGSASLPRARAPGPLLGRQRCLRALHKLSRPLAAEEALRAGSPVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPSEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 760, "header": "tr|A0AAA9STK6-1|A0AAA9STK6_BOVIN Isoform 1 of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=1 CANONICAL=A0AAA9STK6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#A0A3Q1LJA0-1", "sequence": { "sequence": "MRPACLPARPAATRPAGCWGRSPDGQQSRRAAGRRCTPASQLPPLPSRDRGDRAAGARPCAVTSQSGASGPSLSRPPRVSLRPPPPLRRAAPPSGCLSPNLCRGEPARPLEGPKGTPQVPAVWPQESPSMDASRRVRATSVLPTFDASCLFKGHLSTKSNAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPRAVCQYSLQPPSGRKIYSDEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 686, "header": "tr|A0A3Q1LJA0-1|A0AAA9STK6_BOVIN Computationally mapped isoform of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=2 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100155165, "end_pos": 100119197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081367.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081367.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059415.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059415.2" } ] } }, { "isoform_ac": "A0A3Q1MV04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#A0A3Q1MV04-1", "sequence": { "sequence": "MDASRRVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPRAVCQYSLQPPSGRKIYSDDFRHPWGLSGKEPSCQCRDVGSIPGTGRSPRKGNGNPLQDSCLENPMDRGSCEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 641, "header": "tr|A0A3Q1MV04-1|A0A3Q1MV04_BOVIN Computationally mapped isoform of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=2 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100155165, "end_pos": 100119584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085196.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085196.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074588.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074588.2" } ] } }, { "isoform_ac": "A0A3Q1NED9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#A0A3Q1NED9-1", "sequence": { "sequence": "MRPACLPARPAATRPAGCWGRSPDGQQSRRAAGRRCTPASQLPPLPSRDRGDRAAGARPCAVTSQSGASGPSLSRPPRVSLRPPPPLRRAAPPSGCLSPNLCRGEPARPLEGPKGTPQVPAVWPQESPSMDASRRVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPRAVCQYSLQPPSGRKIYSDEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 718, "header": "tr|A0A3Q1NED9-1|A0AAA9STK6_BOVIN Computationally mapped isoform of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=3 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100155165, "end_pos": 100119197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086771.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086771.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069955.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069955.3" } ] } }, { "isoform_ac": "A0AAA9STK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#A0AAA9STK6-1", "sequence": { "sequence": "MRPACLPARPAATRPAGCWGRSPDGQQSRRAAGRRCTPASQLPPLPSRDRGDRAAGARPCAVTSQSGASGPSLSRPPRVSLRPPPPLRRAAPPSGCLSPNLCRGEPARPLEGPKGTPQVPAVWPQESPSMDASRRGKGPPSRAPAGCPAPSGVGSASLPRARAPGPLLGRQRCLRALHKLSRPLAAEEALRAGSPVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPSEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 760, "header": "tr|A0AAA9STK6-1|A0AAA9STK6_BOVIN Isoform 1 of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=1 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100155165, "end_pos": 100119197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125583.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125583.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087472.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087472.1" } ] } }, { "isoform_ac": "A0AAA9T4C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#A0AAA9T4C3-1", "sequence": { "sequence": "MDASRRVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPRAVCQYSLQPPSGRKIYSEFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 563, "header": "tr|A0AAA9T4C3-1|A0AAA9T4C3_BOVIN Computationally mapped isoform of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=1 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100155165, "end_pos": 100119584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118407.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118407.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092649.1" } ] } }, { "isoform_ac": "A0AAA9T5D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#A0AAA9T5D3-1", "sequence": { "sequence": "MDASRRVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQVNEETNLETSVWDEKNGSVSDSLLDQETSVSVIEGDSDTERAEASTELCCLSTALVPAVQLCRVKDSQEVEGPTLRIMEMSIED", "length": 545, "header": "tr|A0AAA9T5D3-1|A0AAA9T5D3_BOVIN Computationally mapped isoform of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=1 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100155165, "end_pos": 100119584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121022.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121022.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091937.1" } ] } }, { "isoform_ac": "F1N521-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6/entry#F1N521-1", "sequence": { "sequence": "MDASRRVRATSVLPTFDASCLFKGHLSTKSNALCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPLSMSASIKYADQQRREKLKKELARCGRGLKFTKTTVHPKSHSRSLLNALQKPSGEPQDENSLLIEEVNEFPSFTQSPVISSERLSLPKSQNVLTNCTEKNSSCSMSSMDYTASGSKKPSSGTSYGRGPRGTFPGSQKFQLVISKAPSGDLLDKHSEHFSNRHLPFTPRTLKTEAKSFLSQYRYYTPAKRKKNFTNRRIEAETQTELSSFKSDFETVEIKNATDSEMNVTQASGCVSYGTKGRTTPSASPGRELPWGKVRDSALQCSSPRAVCQYSLQPPSGRKIYSDEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRQLLHVLKVDLGCMSKENSGKLDSVDTLHLCDVEKAENLEQNENKSEQDLIIQQERQEYQKALNMLLTIPKEENEIVSSNEFFLPIHKSKYSEEVIIQQYLKRQGLSSNQ", "length": 516, "header": "tr|F1N521-1|F1N521_BOVIN Computationally mapped isoform of Spermatosis associated 7 OS=Bos taurus OX=9913 GN=SPATA7 PE=4 SV=2 CANONICAL=A0AAA9STK6-1" }, "locus": { "chromosome": "10", "start_pos": 100156866, "end_pos": 100119584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042997.4", "url": "https://www.ensembl.org/id/ENSBTAT00000042997.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040596.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040596.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 445, "start_aa": "Thr", "end_pos": 445, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr445", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" }, { "name": "photoreceptor distal connecting cilium", "id": "GO:0120206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120206", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" }, { "name": "rod photoreceptor outer segment", "id": "GO:0120200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "photoreceptor cell maintenance", "id": "GO:0045494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 452, "end_pos": 454, "annotation": "n_glycosylation_sequon" }, { "start_pos": 480, "end_pos": 482, "annotation": "n_glycosylation_sequon" }, { "start_pos": 487, "end_pos": 489, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 445 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 355, "end_pos": 357 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 452, "end_pos": 454 }, { "start_pos": 480, "end_pos": 482 }, { "start_pos": 487, "end_pos": 489 }, { "start_pos": 621, "end_pos": 623 }, { "start_pos": 692, "end_pos": 694 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUS7-1", "uniprot_ac": "A0AAA9SUS7", "uniprot_id": "A0AAA9SUS7_BOVIN", "mass": { "chemical_mass": 158935.0, "monoisotopic_mass": 158935.0 }, "refseq": { "ac": "XP_059742027", "name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742027" }, "gene_names": [ { "name": "MAGI2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ] }, { "name": "MAGI2", "type": "synonym", "evidence": [ { "id": "XP_059742027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742027" } ] } ], "protein_names": [ { "name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#names_and_taxonomy" } ] }, { "name": "Atrophin-1-interacting protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#names_and_taxonomy" } ] }, { "name": "Membrane-associated guanylate kinase inverted 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#names_and_taxonomy" } ] }, { "name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8", "type": "synonym", "evidence": [ { "id": "XP_059742027", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742027" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAGI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7", "locus": { "chromosome": "4", "start_pos": 43261744, "end_pos": 41795264, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051262", "url": "https://www.ensembl.org/id/ENSBTAG00000051262" } ] } } ], "crossref": [ { "id": "ENSBTAG00000051262", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051262", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06730", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06730", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06731", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06731", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06732", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06732", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06733", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06733", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06734", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06734", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06735", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06735", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100298336", "url": "https://www.ncbi.nlm.nih.gov/gene/100298336", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10316", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10316", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10316:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10316:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059742027", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP36", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEPEDKSAGASGETPSQPYPAPVYSQPEEVKEQMDDAKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHTLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIIEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNTYSNSNHAVPTSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPASAPSSEKQSPLAQQHSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQPQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYPQPPPLDYRQPPLLDYRQHSPDTRQFPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPGSWSAPAAASPGLPEVGVSLEDVLSPFSPSHPAPPSDPSHQTNPDPTWDIKREHDVRKPKELSAGSQKKQRLGEQSERSASPQRAVQPGLEEAPGGQGQPEAGRPSSETRAPGPALAEAARAGNKEGLQAPVGSELGRHGGPGAAPAFVGPGRGGGAREVEGRAGARAGSRQGSRPPGGAPARKAAVAPGPWKVPGSDKLPGVLKPGASAPGR", "length": 1456, "header": "tr|A0AAA9SUS7-1|A0AAA9SUS7_BOVIN Isoform 1 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Bos taurus OX=9913 GN=MAGI2 PE=3 SV=1 CANONICAL=A0AAA9SUS7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#A0A3Q1LP36-1", "sequence": { "sequence": "MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEPEDKSAGASGETPSQPYPAPVYSQPEEVKEQMDDAKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHTLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIIEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNTYSNSNHAVPTSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPASAPSSEKQSPLAQQHSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQPQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYPQPPPLDYRQPPLLDYRQHSPDTRQFPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPAPGVLPLPPPQVCRK", "length": 1288, "header": "tr|A0A3Q1LP36-1|A0AAA9SUS7_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Bos taurus OX=9913 GN=MAGI2 PE=3 SV=2 CANONICAL=A0AAA9SUS7-1" }, "locus": { "chromosome": "4", "start_pos": 43260147, "end_pos": 41795463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066813.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066813.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061824.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061824.2" } ] } }, { "isoform_ac": "A0AAA9SE52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#A0AAA9SE52-1", "sequence": { "sequence": "MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEPEDKSAGASGETPSQPYPAPVYSQPEEVKEQMDDAKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHTLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIIEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNTYSNSNHAVPTSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPASAPSSEKQSPLAQQHSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQPQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYPQPPPLDYRQPPLLDYRQHSPDTRQFPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTDSSEKHPLSDHQPHHSNSIQ", "length": 1276, "header": "tr|A0AAA9SE52-1|A0AAA9SUS7_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Bos taurus OX=9913 GN=MAGI2 PE=3 SV=1 CANONICAL=A0AAA9SUS7-1" }, "locus": { "chromosome": "4", "start_pos": 43190848, "end_pos": 41795463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098111.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098111.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080663.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080663.1" } ] } }, { "isoform_ac": "A0AAA9SN67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#A0AAA9SN67-1", "sequence": { "sequence": "MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEPEDKSAGASGETPSQPYPAPVYSQPEEVKEQMDDAKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHTLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIIEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNTYSNSNHAVPTSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPASAPSSEKQSPLAQQHSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQPQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYPQPPPLDYRQPPLLDYRQHSPDTRQFPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPGSWSAPAAASPGLPEVGVSLEDVLSPFSPSHPAPPSDPSHQTNPDPTWDIKREHDVRKPKELSAGSQKKQRLGEQSERSASPQRAVQPGLEEAPGGQGQPEAGRPSSETRAPGPALAEAARAGNKEGLQAPVGSELGRHGGPGAAPAFVGPGRGGGAREVEGRAGARAGSRQGSRPPGGAPARKAAVAPGPWKVPGSDKLPGVLKPGASAPGR", "length": 1442, "header": "tr|A0AAA9SN67-1|A0AAA9SUS7_BOVIN Computationally mapped isoform of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Bos taurus OX=9913 GN=MAGI2 PE=3 SV=1 CANONICAL=A0AAA9SUS7-1" }, "locus": { "chromosome": "4", "start_pos": 43260740, "end_pos": 41795463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084275.1" } ] } }, { "isoform_ac": "A0AAA9SUS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7/entry#A0AAA9SUS7-1", "sequence": { "sequence": "MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEPEDKSAGASGETPSQPYPAPVYSQPEEVKEQMDDAKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHTLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIIEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNTYSNSNHAVPTSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPASAPSSEKQSPLAQQHSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQPQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYPQPPPLDYRQPPLLDYRQHSPDTRQFPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPGSWSAPAAASPGLPEVGVSLEDVLSPFSPSHPAPPSDPSHQTNPDPTWDIKREHDVRKPKELSAGSQKKQRLGEQSERSASPQRAVQPGLEEAPGGQGQPEAGRPSSETRAPGPALAEAARAGNKEGLQAPVGSELGRHGGPGAAPAFVGPGRGGGAREVEGRAGARAGSRQGSRPPGGAPARKAAVAPGPWKVPGSDKLPGVLKPGASAPGR", "length": 1456, "header": "tr|A0AAA9SUS7-1|A0AAA9SUS7_BOVIN Isoform 1 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Bos taurus OX=9913 GN=MAGI2 PE=3 SV=1 CANONICAL=A0AAA9SUS7-1" }, "locus": { "chromosome": "4", "start_pos": 43260740, "end_pos": 41795463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086920.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 208, "start_aa": "Thr", "end_pos": 208, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr208", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "positive regulation of receptor internalization", "id": "GO:0002092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002092", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor complex adaptor activity", "id": "GO:0030159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030159", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" }, { "name": "beta-1 adrenergic receptor binding", "id": "GO:0031697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031697", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" }, { "start_pos": 656, "end_pos": 658, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 855, "end_pos": 857, "annotation": "n_glycosylation_sequon" }, { "start_pos": 908, "end_pos": 910, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 109, "end_pos": 185, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 101, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS7" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 302, "end_pos": 335, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 208 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 198, "end_pos": 200 }, { "start_pos": 218, "end_pos": 220 }, { "start_pos": 590, "end_pos": 592 }, { "start_pos": 656, "end_pos": 658 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 855, "end_pos": 857 }, { "start_pos": 908, "end_pos": 910 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVM5-1", "uniprot_ac": "A0AAA9SVM5", "uniprot_id": "A0AAA9SVM5_BOVIN", "mass": { "chemical_mass": 70707.0, "monoisotopic_mass": 70707.0 }, "refseq": { "ac": "XP_002696140", "name": "mitogen-activated protein kinase kinase kinase 3 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696140" }, "gene_names": [ { "name": "MAP3K3", "type": "recommended", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "name": "MAP3K3", "type": "synonym", "evidence": [ { "id": "XP_002696140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696140" } ] } ], "protein_names": [ { "name": "mitogen-activated protein kinase kinase kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.25", "type": "synonym", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#names_and_taxonomy" } ] }, { "name": "mitogen-activated protein kinase kinase kinase 3 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_002696140", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696140" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAP3K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5", "locus": { "chromosome": "19", "start_pos": 47972265, "end_pos": 47913252, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008151", "url": "https://www.ensembl.org/id/ENSBTAG00000008151" } ] } } ], "crossref": [ { "id": "A0AAA9SVM5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06625", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06625", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508943", "url": "https://www.ncbi.nlm.nih.gov/gene/508943", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508943", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508943", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SQDRNHQ", "url": "https://omabrowser.org/oma/group/SQDRNHQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPF2", "url": "https://www.orthodb.org/?gene=A0A3Q1LPF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MH06", "url": "https://www.orthodb.org/?gene=F1MH06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11584", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11584", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11584:SF392", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11584:SF392", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002696140", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696140", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LPF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NU59", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NU59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NU59-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NU59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH06", "url": "https://www.uniprot.org/uniprotkb/F1MH06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH06-1", "url": "https://www.uniprot.org/uniprotkb/F1MH06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEQEALNSIMKDLVALQMSRRPRVPGYETMKSKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTAVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKASQSAGDINTIYQPPESRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEFSDRETPLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLAVQYLDPRARLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 626, "header": "tr|A0AAA9SVM5-1|A0AAA9SVM5_BOVIN Isoform 1 of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K3 PE=3 SV=1 CANONICAL=A0AAA9SVM5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#A0A3Q1LPF2-1", "sequence": { "sequence": "MDEQEALNSIMKDLVALQMSRRPRVPGYETMKSKDTGHPNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTAVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKASQSAGDINTIYQPPESRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEFSDRETPLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLAVQYLDPRARLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 657, "header": "tr|A0A3Q1LPF2-1|A0AAA9SVM5_BOVIN Computationally mapped isoform of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K3 PE=3 SV=1 CANONICAL=A0AAA9SVM5-1" }, "locus": { "chromosome": "19", "start_pos": 47971261, "end_pos": 47913451, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081015.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081015.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058887.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058887.1" } ] } }, { "isoform_ac": "A0AAA9SVM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#A0AAA9SVM5-1", "sequence": { "sequence": "MDEQEALNSIMKDLVALQMSRRPRVPGYETMKSKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTAVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKASQSAGDINTIYQPPESRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEFSDRETPLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLAVQYLDPRARLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 626, "header": "tr|A0AAA9SVM5-1|A0AAA9SVM5_BOVIN Isoform 1 of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K3 PE=3 SV=1 CANONICAL=A0AAA9SVM5-1" }, "locus": { "chromosome": "19", "start_pos": 47971261, "end_pos": 47913451, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114375.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114375.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088066.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088066.1" } ] } }, { "isoform_ac": "A0AAA9T4I5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#A0AAA9T4I5-1", "sequence": { "sequence": "MKCPLHFVPNNKIEEMMFAQTDRMEEDRADEQEALNSIMKDLVALQMSRRPRVPGYETMKSKDTGHPNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTAVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKASQSAGDINTIYQPPESRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEFSDRETPLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLAVQYLDPRARLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 685, "header": "tr|A0AAA9T4I5-1|A0AAA9T4I5_BOVIN Computationally mapped isoform of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K3 PE=3 SV=1 CANONICAL=A0AAA9SVM5-1" }, "locus": { "chromosome": "19", "start_pos": 47971261, "end_pos": 47915148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089639.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089639.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091421.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091421.1" } ] } }, { "isoform_ac": "A0ABI0NU59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#A0ABI0NU59-1", "sequence": { "sequence": "MSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTAVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKASQSAGDINTIYQPPESRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEFSDRETPLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLAVQYLDPRARLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 585, "header": "tr|A0ABI0NU59-1|A0ABI0NU59_BOVIN Computationally mapped isoform of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K3 PE=3 SV=1 CANONICAL=A0AAA9SVM5-1" }, "locus": { "chromosome": "19", "start_pos": 47971261, "end_pos": 47921548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147639.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147639.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107131.1" } ] } }, { "isoform_ac": "F1MH06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5/entry#F1MH06-1", "sequence": { "sequence": "MKDLVALQMSRRPRVPGYETMKSKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTAVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKASQSAGDINTIYQPPESRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEFSDRETPLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLAVQYLDPRARLRSADSENALSVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 612, "header": "tr|F1MH06-1|A0AAA9SVM5_BOVIN Computationally mapped isoform of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K3 PE=3 SV=4 CANONICAL=A0AAA9SVM5-1" }, "locus": { "chromosome": "19", "start_pos": 47971261, "end_pos": 47921324, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010716.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010716.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010716.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010716.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:508943", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508943", "resource": "KEGG Pathway" }, { "id": "R-BTA-9020702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "resource": "Reactome", "description": "Interleukin-1 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AGW3-1", "protein_name": "mitogen-activated protein kinase kinase kinase", "gene_name": "MAP3K3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDEQEALNSIMKDLVALQMSRRPRVPGYETIKNKDTGHPNRQKKHNSSSSALLNSPTVTASSCAGASEKKKFLSDVRVKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSAVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEFSDRETQFYDKGVKGGTYPRRYHVSMHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 657 }, "evidence": [ { "id": "A0AAA9SVM5", "url": "https://omabrowser.org/oma/group/A0AAA9SVM5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3Q2TZP2-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 3", "gene_name": "MAP3K3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDEQEALNSIMKDLVALQMSRRHRLTGFDTMKNKDTAHSNKQKKHNASSPPLLGSPAITNQCASAVEEKKIPNDVRIKFEYHGERRIIPFVRPVRYEDVQQKVKTAFGQPLDLRYVNNELSIPLKNQDDLDKAVDLLDRSSNMKSLRILLLSQDRNHLSDRRVLHVIKQKPTSLKEDSWLHDLIPLREREALFFLKYRMQILFWLCSFSFSGDGKTSSSPHSGLPKQVRIKTSQSVGDVNTPYQQPEPRSRHLSVSSQNTGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETNEQCMLDPLSSAENSVSGSCQSLDSPSFRKSRMSRAQSFPDNRQEFSDRENQIYDKAGKGGTYPRRYNVSMQHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENLGLALQYLDSRGRLRSADSENALAVQERNIPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPESPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHCRDFLKQIFVEARHRPSAEELLRHQFAQLQY", "length": 710 }, "evidence": [ { "id": "A0AAA9SVM5", "url": "https://omabrowser.org/oma/group/A0AAA9SVM5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q61084-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 3", "gene_name": "Map3k3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEQEALDSIMKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY", "length": 626 }, "evidence": [ { "id": "A0AAA9SVM5", "url": "https://omabrowser.org/oma/group/A0AAA9SVM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99759-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 3", "gene_name": "MAP3K3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY", "length": 626 }, "evidence": [ { "id": "A0AAA9SVM5", "url": "https://omabrowser.org/oma/group/A0AAA9SVM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" }, { "name": "MAP kinase kinase kinase activity", "id": "GO:0004709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" }, { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-507719", "name": "p62:MEKK3 binds to TRAF6", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZCC3-1", "A0AAA9SVM5-1" ], "evidence": [ { "id": "R-BTA-507719", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-507719" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q3ZCC3", "gene_name": "TRAF6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3ZCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3ZCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC3" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" }, { "id": "PS51745", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51745" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PB1", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 123, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 362, "end_pos": 622, "start_aa": "Trp", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.25", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25" }, { "id": "2.7.11.25", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVF6-1", "uniprot_ac": "A0AAA9SVF6", "uniprot_id": "A0AAA9SVF6_BOVIN", "mass": { "chemical_mass": 86377.0, "monoisotopic_mass": 86377.0 }, "refseq": { "ac": "XP_059747365", "name": "B-cell lymphoma/leukemia 11A isoform X14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747365" }, "gene_names": [ { "name": "BCL11A", "type": "recommended", "evidence": [ { "id": "A0AAA9SVF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ] }, { "name": "BCL11A", "type": "synonym", "evidence": [ { "id": "XP_059747365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747365" } ] } ], "protein_names": [ { "name": "B-cell lymphoma/leukemia 11A isoform X14", "type": "synonym", "evidence": [ { "id": "XP_059747365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747365" } ] }, { "name": "BCL11 transcription factor A", "type": "synonym", "evidence": [ { "id": "A0AAA9SVF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL11A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6", "locus": { "chromosome": "11", "start_pos": 43208146, "end_pos": 43309895, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016534", "url": "https://www.ensembl.org/id/ENSBTAG00000016534" } ] } } ], "crossref": [ { "id": "A0AAA9SVF6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016534", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016534", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538680", "url": "https://www.ncbi.nlm.nih.gov/gene/538680", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPN0", "url": "https://www.orthodb.org/?gene=A0A3Q1LPN0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N018", "url": "https://www.orthodb.org/?gene=A0A3Q1N018", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45993", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45993", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45993:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45993:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23611", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23611", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25491", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25491", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059747365", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747365", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPN0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPN0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N018", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N018", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N018-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N018-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIAGKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEDEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRPLPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVLHTPPFGVVPRELKMCGSFRMEAREPLSSEKI", "length": 793, "header": "tr|A0AAA9SVF6-1|A0AAA9SVF6_BOVIN Isoform 1 of BCL11 transcription factor A OS=Bos taurus OX=9913 GN=BCL11A PE=4 SV=2 CANONICAL=A0AAA9SVF6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6/entry#A0A3Q1LPN0-1", "sequence": { "sequence": "MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIAEP", "length": 130, "header": "tr|A0A3Q1LPN0-1|A0AAA9SVF6_BOVIN Computationally mapped isoform of BCL11 transcription factor A OS=Bos taurus OX=9913 GN=BCL11A PE=4 SV=2 CANONICAL=A0AAA9SVF6-1" }, "locus": { "chromosome": "11", "start_pos": 43309527, "end_pos": 43279591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078938.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078938.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062044.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062044.2" } ] } }, { "isoform_ac": "A0A3Q1MLZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6/entry#A0A3Q1MLZ2-1", "sequence": { "sequence": "MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEDEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRPLPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCSSHTPIRRSAQRAQDVWQFSDGSSRTLKF", "length": 773, "header": "tr|A0A3Q1MLZ2-1|A0AAA9SVF6_BOVIN Computationally mapped isoform of BCL11 transcription factor A OS=Bos taurus OX=9913 GN=BCL11A PE=4 SV=1 CANONICAL=A0AAA9SVF6-1" }, "locus": { "chromosome": "11", "start_pos": 43309527, "end_pos": 43208777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069124.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069124.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072743.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072743.2" } ] } }, { "isoform_ac": "A0A3Q1N018-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6/entry#A0A3Q1N018-1", "sequence": { "sequence": "MRSRRGARRCEVTARPAEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVLHTPPFGVVPRELKMCGSFRMEAREPLSSEKI", "length": 241, "header": "tr|A0A3Q1N018-1|A0AAA9SVF6_BOVIN Computationally mapped isoform of BCL11 transcription factor A OS=Bos taurus OX=9913 GN=BCL11A PE=4 SV=2 CANONICAL=A0AAA9SVF6-1" }, "locus": { "chromosome": "11", "start_pos": 43307179, "end_pos": 43208767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069722.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069722.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061912.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061912.2" } ] } }, { "isoform_ac": "A0AAA9SVF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6/entry#A0AAA9SVF6-1", "sequence": { "sequence": "MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIAGKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEDEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRPLPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVLHTPPFGVVPRELKMCGSFRMEAREPLSSEKI", "length": 793, "header": "tr|A0AAA9SVF6-1|A0AAA9SVF6_BOVIN Isoform 1 of BCL11 transcription factor A OS=Bos taurus OX=9913 GN=BCL11A PE=4 SV=2 CANONICAL=A0AAA9SVF6-1" }, "locus": { "chromosome": "11", "start_pos": 43309527, "end_pos": 43208767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132757.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132757.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088172.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088172.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 228, "start_aa": "Thr", "end_pos": 228, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr228", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 323, "start_aa": "Thr", "end_pos": 323, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr323", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" }, { "name": "SWI/SNF complex", "id": "GO:0016514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 660, "end_pos": 662, "annotation": "n_glycosylation_sequon" }, { "start_pos": 719, "end_pos": 721, "annotation": "n_glycosylation_sequon" }, { "start_pos": 722, "end_pos": 724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 136, "end_pos": 159, "start_aa": "Tyr", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 228, 323 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 }, { "start_pos": 493, "end_pos": 495 }, { "start_pos": 660, "end_pos": 662 }, { "start_pos": 719, "end_pos": 721 }, { "start_pos": 722, "end_pos": 724 }, { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSX1-1", "uniprot_ac": "A0AAA9SSX1", "uniprot_id": "A0AAA9SSX1_BOVIN", "mass": { "chemical_mass": 56468.0, "monoisotopic_mass": 56468.0 }, "refseq": { "ac": "XP_024842920", "name": "ribonuclease inhibitor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842920" }, "gene_names": [ { "name": "RNH1", "type": "recommended", "evidence": [ { "id": "A0AAA9SSX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ] }, { "name": "RNH1", "type": "synonym", "evidence": [ { "id": "XP_024842920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842920" } ] } ], "protein_names": [ { "name": "Ribonuclease inhibitor", "type": "recommended", "evidence": [ { "id": "A0AAA9SSX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1/entry#names_and_taxonomy" } ] }, { "name": "Ribonuclease/angiogenin inhibitor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SSX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1/entry#names_and_taxonomy" } ] }, { "name": "ribonuclease inhibitor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024842920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842920" } ] } ], "function": [ { "annotation": "Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR1#function" }, { "database": "UniProtKB", "id": "ARBA00049613", "url": "https://www.uniprot.org/uniprotkb/ARBA00049613#function" }, { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1#function" }, { "database": "UniProtKB", "id": "A0A3Q1LQU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQU2#function" }, { "database": "UniProtKB", "id": "H9GW43", "url": "https://www.uniprot.org/uniprotkb/H9GW43#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1", "locus": { "chromosome": "29", "start_pos": 50805178, "end_pos": 50788949, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046869", "url": "https://www.ensembl.org/id/ENSBTAG00000046869" } ] } } ], "crossref": [ { "id": "A0AAA9SSX1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517087", "url": "https://www.ncbi.nlm.nih.gov/gene/517087", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842920", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842920", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H9GW43", "url": "https://www.uniprot.org/uniprotkb/H9GW43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H9GW43-1", "url": "https://www.uniprot.org/uniprotkb/H9GW43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPCAPPRVRAPCGPSSRGTLGAPTRGAEYASAHCLLACLSRVVVGSALWGPASYTTEGLPVRLSFSRNPSLHTMKLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDPGVLQLLGSLEQPACSLEQLVLYDIYWTEAVDERLRAVEESKPGLRIIS", "length": 530, "header": "tr|A0AAA9SSX1-1|A0AAA9SSX1_BOVIN Isoform 1 of Ribonuclease inhibitor OS=Bos taurus OX=9913 GN=RNH1 PE=1 SV=1 CANONICAL=A0AAA9SSX1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1/entry#A0A3Q1LQU2-1", "sequence": { "sequence": "MKLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDPGVLQLLGSLEQPACSLEQLPVRHLLDRGSGRAPAGCGGEQAWPADHLLSPVPHGALTEKRSSQLISGGES", "length": 478, "header": "tr|A0A3Q1LQU2-1|A0AAA9SSX1_BOVIN Computationally mapped isoform of Ribonuclease inhibitor OS=Bos taurus OX=9913 GN=RNH1 PE=1 SV=1 CANONICAL=A0AAA9SSX1-1" }, "locus": { "chromosome": "29", "start_pos": 50804274, "end_pos": 50796233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071430.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071430.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059478.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059478.2" } ] } }, { "isoform_ac": "A0AAA9SSR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1/entry#A0AAA9SSR1-1", "sequence": { "sequence": "MRVASAPATAPLSSAACGVFSGEPPPAPDPGGEVDRGNPSLHTMKLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDPGVLQLLGSLEQPACSLEQLVLYDIYWTEAVDERLRAVEESKPGLRIIS", "length": 499, "header": "tr|A0AAA9SSR1-1|A0AAA9SSR1_BOVIN Computationally mapped isoform of Ribonuclease inhibitor OS=Bos taurus OX=9913 GN=RNH1 PE=1 SV=1 CANONICAL=A0AAA9SSX1-1" }, "locus": { "chromosome": "29", "start_pos": 50804206, "end_pos": 50795961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119579.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119579.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086067.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086067.1" } ] } }, { "isoform_ac": "A0AAA9SSX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1/entry#A0AAA9SSX1-1", "sequence": { "sequence": "MAPCAPPRVRAPCGPSSRGTLGAPTRGAEYASAHCLLACLSRVVVGSALWGPASYTTEGLPVRLSFSRNPSLHTMKLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDPGVLQLLGSLEQPACSLEQLVLYDIYWTEAVDERLRAVEESKPGLRIIS", "length": 530, "header": "tr|A0AAA9SSX1-1|A0AAA9SSX1_BOVIN Isoform 1 of Ribonuclease inhibitor OS=Bos taurus OX=9913 GN=RNH1 PE=1 SV=1 CANONICAL=A0AAA9SSX1-1" }, "locus": { "chromosome": "29", "start_pos": 50804206, "end_pos": 50789148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093102.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093102.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089506.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089506.1" } ] } }, { "isoform_ac": "H9GW43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1/entry#H9GW43-1", "sequence": { "sequence": "MKLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLRWGQCWLEEAEPERPSWARSLPGRQPLAPVLSHLGARQPLLSSSLRRGETRPDRLEYCSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLW", "length": 253, "header": "tr|H9GW43-1|H9GW43_BOVIN Computationally mapped isoform of Ribonuclease inhibitor OS=Bos taurus OX=9913 GN=RNH1 PE=1 SV=2 CANONICAL=A0AAA9SSX1-1" }, "locus": { "chromosome": "29", "start_pos": 50803051, "end_pos": 50796233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065344.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065344.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055564.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055564.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" }, { "name": "angiogenin-PRI complex", "id": "GO:0032311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032311", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of angiogenesis", "id": "GO:0045765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" }, { "name": "tRNA stabilization", "id": "GO:0036416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ribonuclease inhibitor activity", "id": "GO:0008428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008428", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 453, "end_pos": 455 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST16-1", "uniprot_ac": "A0AAA9ST16", "uniprot_id": "A0AAA9ST16_BOVIN", "mass": { "chemical_mass": 61608.0, "monoisotopic_mass": 61608.0 }, "refseq": { "ac": "XP_024850724", "name": "protein ENL isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850724" }, "gene_names": [ { "name": "MLLT1", "type": "recommended", "evidence": [ { "id": "A0AAA9ST16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ] }, { "name": "MLLT1", "type": "synonym", "evidence": [ { "id": "XP_024850724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850724" } ] } ], "protein_names": [ { "name": "MLLT1 super elongation complex subunit", "type": "synonym", "evidence": [ { "id": "A0AAA9ST16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#names_and_taxonomy" } ] }, { "name": "protein ENL isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024850724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850724" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MLLT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16", "locus": { "chromosome": "7", "start_pos": 18208763, "end_pos": 18141335, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002277", "url": "https://www.ensembl.org/id/ENSBTAG00000002277" } ] } } ], "crossref": [ { "id": "A0AAA9ST16", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002277", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002277", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16906", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16906", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504458", "url": "https://www.ncbi.nlm.nih.gov/gene/504458", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504458", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504458", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRT9", "url": "https://www.orthodb.org/?gene=A0A3Q1LRT9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSC1", "url": "https://www.orthodb.org/?gene=A0A3Q1LSC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4L4", "url": "https://www.orthodb.org/?gene=F1N4L4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47827:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47827:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024850724", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRT9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSC1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P331", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P331", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P331-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P331-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4L4", "url": "https://www.uniprot.org/uniprotkb/F1N4L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4L4-1", "url": "https://www.uniprot.org/uniprotkb/F1N4L4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGVMVIPEGAETVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 556, "header": "tr|A0AAA9ST16-1|A0AAA9ST16_BOVIN Isoform 1 of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=1 CANONICAL=A0AAA9ST16-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#A0A3Q1LRT9-1", "sequence": { "sequence": "MDNQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 514, "header": "tr|A0A3Q1LRT9-1|A0AAA9ST16_BOVIN Computationally mapped isoform of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=2 CANONICAL=A0AAA9ST16-1" }, "locus": { "chromosome": "7", "start_pos": 18207759, "end_pos": 18141711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072745.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072745.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059896.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059896.2" } ] } }, { "isoform_ac": "A0A3Q1LSC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#A0A3Q1LSC1-1", "sequence": { "sequence": "MRHAGRAAEVGAGLWISGQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGVMVIPEGAETVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 571, "header": "tr|A0A3Q1LSC1-1|A0A3Q1LSC1_BOVIN Computationally mapped isoform of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=2 CANONICAL=A0AAA9ST16-1" }, "locus": { "chromosome": "7", "start_pos": 18207759, "end_pos": 18147908, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073317.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073317.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060129.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060129.2" } ] } }, { "isoform_ac": "A0AAA9RZ50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#A0AAA9RZ50-1", "sequence": { "sequence": "MVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGVMVIPEGAETVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 524, "header": "tr|A0AAA9RZ50-1|A0AAA9ST16_BOVIN Computationally mapped isoform of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=1 CANONICAL=A0AAA9ST16-1" }, "locus": { "chromosome": "7", "start_pos": 18207759, "end_pos": 18151522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114877.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114877.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077910.1" } ] } }, { "isoform_ac": "A0AAA9ST16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#A0AAA9ST16-1", "sequence": { "sequence": "MDNQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGVMVIPEGAETVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 556, "header": "tr|A0AAA9ST16-1|A0AAA9ST16_BOVIN Isoform 1 of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=1 CANONICAL=A0AAA9ST16-1" }, "locus": { "chromosome": "7", "start_pos": 18207759, "end_pos": 18141711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118865.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118865.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089556.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089556.1" } ] } }, { "isoform_ac": "A0ABI0P331-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#A0ABI0P331-1", "sequence": { "sequence": "MSVASGPGTSLSLTGHTVLFSGDLGERYCSGRAANLRAEQCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGVMVIPEGAETVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 592, "header": "tr|A0ABI0P331-1|A0ABI0P331_BOVIN Computationally mapped isoform of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=1 CANONICAL=A0AAA9ST16-1" }, "locus": { "chromosome": "7", "start_pos": 18207759, "end_pos": 18150882, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148704.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148704.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105532.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105532.1" } ] } }, { "isoform_ac": "F1N4L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16/entry#F1N4L4-1", "sequence": { "sequence": "MSGSSVCRGCTVQVKLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCEIQHFVEKVVFRLHDSFPKPKRVCKEPPYKVEESGYAGFIMPIEVYFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTVEFRYKLLMAGGVMVIPEGAETVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDASKESSKACKAHKATKEHRERPRKDSESRGTSKEPEREQARSAKDAARKLGEGRPPKEEKAPPPKAAFKEPKMALKETKLEGMSPKGGPPPPPPPKSSSKRPATADSPKPSAKKQKKSSSKGSRSAPSTSPRTSSSSFSDKKPAKDKGSTKGEKVKAENESREIKKPPEVEESNSEDEASFKTESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNAGRDSRLSFSDSESDNSGDSCLPSREPPPPKKPPPPNSKASGRRSPEPCGKPEKILKRGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSYLEAVAT", "length": 561, "header": "tr|F1N4L4-1|F1N4L4_BOVIN Computationally mapped isoform of MLLT1 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT1 PE=4 SV=4 CANONICAL=A0AAA9ST16-1" }, "locus": { "chromosome": "7", "start_pos": 18207759, "end_pos": 18149142, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002936.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002936.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002936.7", "url": "https://www.ensembl.org/id/ENSBTAP00000002936.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504458", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504458", "resource": "KEGG Pathway" }, { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ], "pmid": "" }, { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST16" }, { "id": "PS51037", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YEATS", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 138, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 342, "end_pos": 344 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 393, "end_pos": 395 }, { "start_pos": 526, "end_pos": 528 }, { "start_pos": 529, "end_pos": 531 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU98-1", "uniprot_ac": "A0AAA9SU98", "uniprot_id": "A0AAA9SU98_BOVIN", "mass": { "chemical_mass": 73947.0, "monoisotopic_mass": 73947.0 }, "refseq": {}, "gene_names": [ { "name": "DYM", "type": "recommended", "evidence": [ { "id": "A0AAA9SU98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98" } ] } ], "protein_names": [ { "name": "Dymeclin", "type": "recommended", "evidence": [ { "id": "A0AAA9SU98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DYM", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98", "locus": { "chromosome": "24", "start_pos": 48722549, "end_pos": 49123057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000024", "url": "https://www.ensembl.org/id/ENSBTAG00000000024" } ] } } ], "crossref": [ { "id": "A0AAA9SU98", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000024", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000024", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613923", "url": "https://www.ncbi.nlm.nih.gov/gene/613923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VWTLVCK", "url": "https://omabrowser.org/oma/group/VWTLVCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MB15", "url": "https://www.orthodb.org/?gene=A0A3Q1MB15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPF2", "url": "https://www.orthodb.org/?gene=A0A3Q1MPF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BE17", "url": "https://www.orthodb.org/?gene=E1BE17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12895", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12895", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12895:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12895:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MB15", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB15-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T490", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T490", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T490-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T490-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE17", "url": "https://www.uniprot.org/uniprotkb/E1BE17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE17-1", "url": "https://www.uniprot.org/uniprotkb/E1BE17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGTHVLPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKVAAASELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKMQVFHGKEDHCAATYKTPGSMTKTFCHLHEPCPHT", "length": 655, "header": "tr|A0AAA9SU98-1|A0AAA9SU98_BOVIN Isoform 1 of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=1 CANONICAL=A0AAA9SU98-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MB15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#A0A3Q1MB15-1", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGTHVLPQQSDGGGLLYGLASGVANSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNSAVGVYWNPQDIQLFTMDSD", "length": 608, "header": "tr|A0A3Q1MB15-1|A0AAA9SU98_BOVIN Computationally mapped isoform of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=2 CANONICAL=A0AAA9SU98-1" }, "locus": { "chromosome": "24", "start_pos": 49099386, "end_pos": 48722801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082102.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082102.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071236.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071236.2" } ] } }, { "isoform_ac": "A0A3Q1MPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#A0A3Q1MPF2-1", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLAGLWTVFTLGGVGSKVAAASELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNSAVGVYWNPQDIQLFTMDSD", "length": 479, "header": "tr|A0A3Q1MPF2-1|A0AAA9SU98_BOVIN Computationally mapped isoform of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=2 CANONICAL=A0AAA9SU98-1" }, "locus": { "chromosome": "24", "start_pos": 49099386, "end_pos": 48722801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085117.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085117.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071537.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071537.2" } ] } }, { "isoform_ac": "A0AAA9SU98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#A0AAA9SU98-1", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGTHVLPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKVAAASELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKMQVFHGKEDHCAATYKTPGSMTKTFCHLHEPCPHT", "length": 655, "header": "tr|A0AAA9SU98-1|A0AAA9SU98_BOVIN Isoform 1 of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=1 CANONICAL=A0AAA9SU98-1" }, "locus": { "chromosome": "24", "start_pos": 49099386, "end_pos": 48726124, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110491.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110491.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090010.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090010.1" } ] } }, { "isoform_ac": "A0AAA9T490-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#A0AAA9T490-1", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGTHVLPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKVAAASELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKVALCPVAHTPWKQPRLGPQPT", "length": 641, "header": "tr|A0AAA9T490-1|A0AAA9T490_BOVIN Computationally mapped isoform of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=1 CANONICAL=A0AAA9SU98-1" }, "locus": { "chromosome": "24", "start_pos": 49099386, "end_pos": 48730111, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114923.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114923.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092609.1" } ] } }, { "isoform_ac": "A0AAA9U1A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#A0AAA9U1A8-1", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGTHVLPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKVAAASELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLPCHGMSKGLEAMSHSVPGHPRGTGHSAEF", "length": 611, "header": "tr|A0AAA9U1A8-1|A0AAA9U1A8_BOVIN Computationally mapped isoform of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=1 CANONICAL=A0AAA9SU98-1" }, "locus": { "chromosome": "24", "start_pos": 49099386, "end_pos": 48803764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128272.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128272.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102969.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102969.1" } ] } }, { "isoform_ac": "E1BE17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98/entry#E1BE17-1", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGTHVLPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKVAAASELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVMLKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIVSYTCRHLRRYVYVLDKLYFPHSHCSTLQHCFSTLSDNGEELLSLTCSHILRSYASSLFSLLSKKHNKVLEQATQSLRGSLSSSDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNSAVGVYWNPQDIQLFTMDSD", "length": 724, "header": "tr|E1BE17-1|A0AAA9SU98_BOVIN Computationally mapped isoform of Dymeclin OS=Bos taurus OX=9913 GN=DYM PE=3 SV=2 CANONICAL=A0AAA9SU98-1" }, "locus": { "chromosome": "24", "start_pos": 49099386, "end_pos": 48722801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061332.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061332.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053667.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053667.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A480JQY8-1", "protein_name": "Dymeclin", "gene_name": "DYM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESVSENDPFWNQLLSFSFPAPTSSTELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKSPGSYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAVSTMVVFLSCQLFHKEVLRQSISHKYLMRGRCLPYTSKLVKTLLYNFIRQEKPPPPGAHVLPQQSDSGGLLYGLASGVATGLWTVFTLGGVGSKAAAAPELSSPLANQSLLLLLVLANLTDAADAPNPYRQAIMSFKNTQDSSPFPSSNPHAFQINFNSLYMALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLSSNDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVITFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNTAVGLYWNPQDIQLFTMDSD", "length": 669 }, "evidence": [ { "id": "A0AAA9SU98", "url": "https://omabrowser.org/oma/group/A0AAA9SU98/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5ZLW3-1", "protein_name": "Dymeclin", "gene_name": "DYM", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGANSSSISELPDNEYLKKLSGAEPISENDPFWNQLLSFSFTTPTNSADLKLLEEATVSVCKSLVEKNPRTGNLGSLIKVFLSRTKELKISAECQNHLFIWQAHNALFIICCLLKVFISRMSEEELQLHFTYEDKTPGSYGTECEDLIEELLCCLIQLIVEIPLLDITYSISLEAVTTLIVFLSCQLFHKEILRESLIHKYLMRGRCLPYTSRLVKTLLYNFIRQERSPPPGSHVFQQQTDGGGLLYGIASGVATGLWTVFTLGGVGSKATPQLDQCSPLANQSLLLLLVLANLTDAPDTPNPYRQAIMSFKNTQDSSAFSSSHPHVFQINFNSLYTALCEQQKSDQATLLLYMLLHQNGNVRTYVLARTDIENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYAERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLDSNDSPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLEHAGAELSVERVLEIIKQGAVALPKDRLRKFPELKFKYVEEEQPEEFFIPYVWSLVYNAAVALYWNPRDIQLFTMDSG", "length": 669 }, "evidence": [ { "id": "A0AAA9SU98", "url": "https://omabrowser.org/oma/group/A0AAA9SU98/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7KNA0-1", "protein_name": "Dymeclin", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGINVSRTADLGSNQWLQRFVGRQHIAHDDEAFWNGLLNYNIVLPENSQDQLNLDSRLEALCQSFIGNNLKTGNFGSLVTVFLEKTSELLSLSDQESNMHVWQTFNALFIIRSLVKYINETGSEFQLLQHFEAMPNAELLQAALEQQQQTPAESATIAMEATEQSAAAAVPVIVDGSKFETFIDALVNLIVVIPVKEFTYHLHLEAVNMLITLLSVHLFAQQPTDKSIVFRTVFKCQHANVLMSALLHFVARIVEVPHTMFGSSSAGSFVFGIAESLLSIFTFRKQPDILKAGQAAGGGELSQRFRTHYPLANQSLLLILILTNHCTAQDNAYRTSLFSCADSKDSPKQGAVSFQIDFSAVYETLCTIVTIDQATLLLYLLLHRNERFYRFVMQQQDLEQLVIPILQTLYNAPDSNSHHIYMSLIVLLILSEDEGFNKNVHTIMLKNITWYTERTISEISLGGILILIVIRTIQYNMLKMRDKYLHTNCLAALANMSGHFRALHPYVAQRLVSLFETLARKHTRLDAQLKEPADSAVFVNVSTTPEDMLQDLSVLEEVLRMVLEILNSCLTNQLVYCPNLVYTLLYKRSVFEGFRSHHAFQDVIQNIDMVVGFFSSRLQRVQEQRGELGVNEVLEVISKGASQWSSDRLRKFPDLKFKYVEEDAPEEFFIPYVWTLVCKYGCVHFSSESIKSVTTDIAC", "length": 699 }, "evidence": [ { "id": "A0AAA9SU98", "url": "https://omabrowser.org/oma/group/A0AAA9SU98/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q7RTS9-1", "protein_name": "Dymeclin", "gene_name": "DYM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSNSSRIGDLPKNEYLKKLSGTESISENDPFWNQLLSFSFPAPTSSSELKLLEEATISVCRSLVENNPRTGNLGALIKVFLSRTKELKLSAECQNHIFIWQTHNALFIICCLLKVFICQMSEEELQLHFTYEEKSPGNYSSDSEDLLEELLCCLMQLITDIPLLDITYEISVEAISTMVVFLSCQLFHKEVLRQSISHKYLMRGPCLPYTSKLVKTLLYNFIRQEKPPPPGAHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGVGSKAAASPELSSPLANQSLLLLLVLANLTDASDAPNPYRQAIMSFKNTQDSSPFPSSIPHAFQINFNSLYTALCEQQTSDQATLLLYTLLHQNSNIRTYMLARTDMENLVLPILEILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGSLSSNDVPLPDYAQDLNVIEEVIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQAGAELSVERVLEIIKQGVVALPKDRLKKFPELKFKYVEEEQPEEFFIPYVWSLVYNSAVGLYWNPQDIQLFTMDSD", "length": 669 }, "evidence": [ { "id": "A0AAA9SU98", "url": "https://omabrowser.org/oma/group/A0AAA9SU98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 282, "end_pos": 284 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 411, "end_pos": 413 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 450, "end_pos": 452 }, { "start_pos": 469, "end_pos": 471 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUY6-1", "uniprot_ac": "A0AAA9SUY6", "uniprot_id": "A0AAA9SUY6_BOVIN", "mass": { "chemical_mass": 27286.0, "monoisotopic_mass": 27286.0 }, "refseq": {}, "gene_names": [ { "name": "MAGIX", "type": "recommended", "evidence": [ { "id": "A0AAA9SUY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6" } ] } ], "protein_names": [ { "name": "MAGI family member, X-linked", "type": "synonym", "evidence": [ { "id": "A0AAA9SUY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAGIX", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6", "locus": { "chromosome": "X", "start_pos": 87214030, "end_pos": 87208764, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013278", "url": "https://www.ensembl.org/id/ENSBTAG00000013278" } ] } } ], "crossref": [ { "id": "A0AAA9SUY6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUY6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013278", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013278", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06735", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06735", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511713", "url": "https://www.ncbi.nlm.nih.gov/gene/511713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR47646", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47646", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47646:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47646:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RWJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSW3", "url": "https://www.uniprot.org/uniprotkb/F1MSW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSW3-1", "url": "https://www.uniprot.org/uniprotkb/F1MSW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERRPGGGTDPRGSKGGGGGPQPEDASARQFLARLKARPLAARAAADVAALVRRAGATLRLRPKEAISMLYSAEIEVTDNRLPNANFVEQRPQAGDLVLHINGESTQGLTHVEVVDRIRRGGPRLCLVLSRPPETHPGKPEVVGRPQKEDDRIPDPGEPEMTKTRSASTSSPLQHPRPRTTPQNRGSQEPRLEGAADGPAVLAAERRTEDPNDQTPDSPGPWLTPSEERLSRALGVPGAEQLALEMATGRRRH", "length": 253, "header": "tr|A0AAA9SUY6-1|A0AAA9SUY6_BOVIN Isoform 1 of MAGI family member, X-linked OS=Bos taurus OX=9913 GN=MAGIX PE=4 SV=1 CANONICAL=A0AAA9SUY6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6/entry#A0AAA9RWJ2-1", "sequence": { "sequence": "MPISWNSVHRYYLVLLIKATCLRAMYVHLCPLQHRRSETMGIRTAPPQVTQGKAHPPLKSPQASGQFSVELIRSSAGFGFTLSGGRDAGGDAPLAVRRLLKDGPAQRCGRLQAGDLVLHINGESTQGLTHVEVVDRIRRGGPRLCLVLSRPPETHPGKPEVVGRPQKEDVLPSPDRIPDPGEPEMTKTRSASTSSPLQHPRPRTTPQNRGSQEPRLEGAADGPAVLAAERRTEDPNDQTPDSPGPWLTPSEERLSRALGVPGAEQLALEMATGRRRH", "length": 277, "header": "tr|A0AAA9RWJ2-1|A0AAA9SUY6_BOVIN Computationally mapped isoform of MAGI family member, X-linked OS=Bos taurus OX=9913 GN=MAGIX PE=4 SV=2 CANONICAL=A0AAA9SUY6-1" }, "locus": { "chromosome": "X", "start_pos": 87213026, "end_pos": 87211398, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127828.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127828.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076798.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076798.2" } ] } }, { "isoform_ac": "A0AAA9SK42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6/entry#A0AAA9SK42-1", "sequence": { "sequence": "MERRPGGGTDPRGSKGGGGGPQPEDASARQFLARLKARPLAARAAADVAALVRRAGATLRLRPKEAISMLYSAEIEVTDNRLPNANFVEQRPQHRRSETMGIRTAPPQVTQGKAHPPLKSPQASGQFSVELIRSSAGFGFTLSGGRDAGGDAPLAVRRLLKDGPAQRCGRLQAGDLVLHINGESTQGLTHVEVVDRIRRGGPRLCLVLSRPPETHPGKPEVVGRPQKEDALRVCRPPSAKELHPHCPPYRPILSAVLPSPDRIPDPGEPEMTKTRSASTSSPLQHPRPRTTPQNRGSQEPRLEGAADGPAVLAAERRTEDPNDQTPDSPGPWLTPSEERLSRALGVPGAEQLALEMATGRRRH", "length": 363, "header": "tr|A0AAA9SK42-1|A0AAA9SUY6_BOVIN Computationally mapped isoform of MAGI family member, X-linked OS=Bos taurus OX=9913 GN=MAGIX PE=4 SV=1 CANONICAL=A0AAA9SUY6-1" }, "locus": { "chromosome": "X", "start_pos": 87213026, "end_pos": 87209473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114411.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114411.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082961.1" } ] } }, { "isoform_ac": "A0AAA9SUY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6/entry#A0AAA9SUY6-1", "sequence": { "sequence": "MERRPGGGTDPRGSKGGGGGPQPEDASARQFLARLKARPLAARAAADVAALVRRAGATLRLRPKEAISMLYSAEIEVTDNRLPNANFVEQRPQAGDLVLHINGESTQGLTHVEVVDRIRRGGPRLCLVLSRPPETHPGKPEVVGRPQKEDDRIPDPGEPEMTKTRSASTSSPLQHPRPRTTPQNRGSQEPRLEGAADGPAVLAAERRTEDPNDQTPDSPGPWLTPSEERLSRALGVPGAEQLALEMATGRRRH", "length": 253, "header": "tr|A0AAA9SUY6-1|A0AAA9SUY6_BOVIN Isoform 1 of MAGI family member, X-linked OS=Bos taurus OX=9913 GN=MAGIX PE=4 SV=1 CANONICAL=A0AAA9SUY6-1" }, "locus": { "chromosome": "X", "start_pos": 87213026, "end_pos": 87209473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134864.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134864.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087779.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087779.1" } ] } }, { "isoform_ac": "F1MSW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6/entry#F1MSW3-1", "sequence": { "sequence": "MWKGLPRWLSGQESACPCRSLRRHGFDSWVGKIPWRRPWQPIPVFLPGEPMDRGAWRATVHGITKSQTRLRDFPRKMWKALLEAAVHLGGGGPQPEDASARQFLARLKARPLAARAAADVAALVRRAGATLRLRPKEAISMLYSAEIEVTDNRLPNANFVEQRPQHRRSETMGIRTAPPQVTQGKAHPPLKSPQASGQFSVELIRSSAGFGFTLSGGRDAGGDAPLAVRRLLKDGPAQRCGRLQAGDLVLHINGESTQGLTHVEVVDRIRRGGPRLCLVLSRPPETHPGKPEVVGRPQKEDALRVCRPPSAKELHPHCPPYRPILSAVLPSPDRIPDPGEPEMTKTRSASTSSPLQHPRPRTTPQNRGSQEPRLEGAADGPAVLAAERRTEDPNDQTPDSPGPWLTPSEERLSRALGVPGAEQLALEMATGRRRH", "length": 435, "header": "tr|F1MSW3-1|A0AAA9SUY6_BOVIN Computationally mapped isoform of MAGI family member, X-linked OS=Bos taurus OX=9913 GN=MAGIX PE=4 SV=3 CANONICAL=A0AAA9SUY6-1" }, "locus": { "chromosome": "X", "start_pos": 87213026, "end_pos": 87208861, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017659.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017659.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017659.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017659.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511713", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY6" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 133, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUN5-1", "uniprot_ac": "A0AAA9SUN5", "uniprot_id": "A0AAA9SUN5_BOVIN", "mass": { "chemical_mass": 310029.0, "monoisotopic_mass": 310029.0 }, "refseq": {}, "gene_names": [ { "name": "VWF", "type": "recommended", "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ] } ], "protein_names": [ { "name": "von Willebrand factor", "type": "recommended", "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5/entry#names_and_taxonomy" } ] }, { "name": "vWF", "type": "synonym", "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5#function" }, { "database": "UniProtKB", "id": "PIRNR002495", "url": "https://www.uniprot.org/uniprotkb/PIRNR002495#function" }, { "database": "UniProtKB", "id": "ARBA00059961", "url": "https://www.uniprot.org/uniprotkb/ARBA00059961#function" }, { "database": "UniProtKB", "id": "A0A3Q1LLU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU1#function" }, { "database": "UniProtKB", "id": "A0AAA9TPC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VWF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5", "locus": { "chromosome": "5", "start_pos": 104345680, "end_pos": 104221024, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012265", "url": "https://www.ensembl.org/id/ENSBTAG00000012265" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012265", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012265", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01450", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01450", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19941", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19941", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLU1", "url": "https://www.orthodb.org/?gene=A0A3Q1LLU1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11339:SF361", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11339:SF361", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16164", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16164", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23244", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23244", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25962", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25962", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-354192", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-354194", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-354194", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-372708", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-430116", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430116", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769735", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769735", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769739", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769743", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769743", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LLU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLU1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDYSLPGSSICEDSPGKNTGMFPTRLARLLLAVALTLPGALCGEGALGKSSMARCSLFGADFINTFDESMYSFSGDCSYLLAGDCKTHSFSIVGDFQGGRRMGLSVYLGEFFDIHVFVNGTVLQGGQHVSMPYATRGLYLETEVGHHKLSSESYGFVARIDGSGNFQILLSDRHFNKTCGLCGDFNIFAEDDFRTQEGTLTSDPYDFANSWALSSEEQRCPRVSPPSSSCNVSSELQKGLWEKCQLLKTASVFARCHALVDPEPFVALCERMLCACAQGLRCPCPVLLEYARACAKQGMLLYGWADHSSCRPDCPAGMEYKECVSPCHRTCRSLSITEVCREQCVDGCSCPEGQLLDEGRCVESTECPCVHAGKPYPPGASLSRDCNTCICRNSQWVCSNEDCPGECLITGQSHFKSFDDRHFTFSGVCQYLLAQDCQDHSFSVVIETVQCADDPDAVCTRSVTVRLPSPHHGLLKLKHGGGVALDGQDIQIPLLQGDLRIQHTVTASLQLNFGEDLQIDWDGRGRLLLKLSPVYAGRTCGLCGNYNGNQRDDFLTPAGLVEPLVEHFGNSWKLRADCEDLQEQPSDPCSLNPRLTKFADQACAILTSPKFEACHSAVSPLPYLRNCRYDVCACSDGRDCLCDAVANYAAACARRGVHVGWREPSFCALSCTHGQVYQQCGTPCNLTCRSLSHPDEECTEVCLEGCFCPPGLFLDETGSCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCSTSGAPGSLLPEAVLSSPLSHRSKRSLSCRPPMVKVVCPADNPRAEGLECTKTCQNYDLECMSTGCVSGCLCPPGMVRHENRCVALERCPCFHQGREYAPGDRVKVDCNSCVCQDRKWNCTDHVCDASCSALGLAHYFTFDGLKYLFPGECQYVLVQDHCGSNPGTFRVLVGNEGCSVPSLKCRKRITILVEGGEIELFDGEVNVKTPMKDETHFEVVESGRYITVLLGKALSVVWDGHLAVSVFLKRTYQERVCGLCGNFDGVQNNDLTSSSLQVEENPVDFGNSWKVSPQCADTQKVRLDSAPAICHDNVMKQTMVDSSCRVLTSDVFRECNRLVNPEPYLDVCIYDSCSCESIGDCSCFCDTIAAYAHECAQHGQVVTWRTATLCPQNCEERNLKESGYQCEWRYNSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVNPEDCPVCQVEGRRLASGKKVTLNPGDPEHCQICHCDGVSLTCEACKEPGGPPPTEGPVIPTTPYVEDIPEPPLHDFFCSKLLDLVFLLDGSSKLSEADFETLKAFVVGMMERLHISQKRIRVAVVEYHDGSHAYLALQDRKRPSELRRIAGQVKYAGSEVASTSEVLKYTLFQIFGRIDRPEASRVALLLTASQEPPRLARNLVRYVQGLKKKKVSVVPVGIGPHASLKQIRLIEKQAPENKAFVLSGVHELEQRMDDIVGYLCDLALEVPAPTLTQHPLAAQVTVAPQLLGPSLPGPKRSSVVLDVAFLLEGSDEVGEANFNRSAEFVEEVIRRMDVGQDGIHVTVLQYSYVVTVEHSFREPQSKDVVLQRLREVRYRGGNQTNTGLALQYLSEHSFSASQGDREQAPNLVYMVTGSPASDKIQRMPGDIQLVPIGVGPRVDVQELERVSWPQTPIFIQDFERLPREAPDLVLQRCCSEDGPHLPTLAPAPDCSQPLDVVLLLDGSSTSPASYFDEMKSFAKAFISKANLGPQLTQVSVLQYGSNTNVDVPWDIHVDKAHLLSLVDPMHREGGPSQVGQALSFAARYITSQVHGARPSASKVVVILVTGSSMDSVEAAAAAARSNRVAVFPIGIGDQYDAAQLRVLAGPGASSNVAELQRIEDLPSMVALGNSFFQRLCSGFVSVCVDEDGNERRPGDVWTLLDQCHTVTCLPDGQTLLKSHRVNCDQGPQPSCPDGQTPLRMEEACGCRWACPCVCTGSSTRHIVTFDGRNFKLTGNCSYVLFHNKEQDLEVILHNGFCSAGARQACMKSVEVKQNGLSVELRSNMEVMVNGRLVSVPYLGGDMEVRVYGTIMFEVRFMGHILSFTPQNNEFQLQLRPKIFASKTYGLCGFCDENGANDFMLRDGTVTEDWKTLVREWTVQQPGQTCPLGPEEPCPISQGSRCQVLLSELFAECHKVLAPATFHAMCQQDSCQQEQVCEAIASYAHLCRTKGVCVDWRTPDFCAVSCPPSLIYNHCESGCPRQCEGNSSSCGDHPLEGCFCPPHQVMLEGSCVPEEACTQCVGDDGIRHQLLETWVPDHQPCQICTCLSGRKVNCTTQPCPSAGVPTCGPCEVARLRQSTQQCCPEYECVCDLVSCDVPPVPNCEDGLQPVLANPGECRPSFTCVCRKEECPKGSPPSCPPHRMPALRKTRCCDEYECACNCTNSTVSCPLGYLASTITNDCSCTTTTCLPDKVCVHRGTIYPVGQFWEEGCDTCTCTDLEDAVMGLRVAQCSQKPCADICRPGFTYVLREGECCGRCLPSACEVVTGSPRGDSQTQWKSVGSHWASPENPCLIHECVRVEEEVFVQQRNVSCPQLNVPVCPLGFQLRCQTLGCCPTCRCEPVQACVLNGTIIGPGKTVMVDACMTCRCHVQAGVISGFKLECRKTTCQACPAGYMEEKLQGECCGRCLPTACTIQLRGGQIMMLKRDETLQDGCDSHFCKVNKRGEFIWEKRVMSCPPFNEHKCLAEGGEIMKIPGTCCDTCEEPECKDITARVKSIKVGDCKSEDEVDIHYCQGRCTSKALYSIDTEDVQDQCSCCSPTRTEPMPVPLRCTNGSIIHHVVLNALQCQCSSRKCSP", "length": 2830, "header": "tr|A0AAA9SUN5-1|A0AAA9SUN5_BOVIN Isoform 1 of von Willebrand factor OS=Bos taurus OX=9913 GN=VWF PE=4 SV=1 CANONICAL=A0AAA9SUN5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5/entry#A0A3Q1LLU1-1", "sequence": { "sequence": "MFPTRLARLLLAVALTLPGALCGEGALGKSSMARCSLFGADFINTFDESMYSFSGDCSYLLAGDCKTHSFSIVGDFQGGRRMGLSVYLGEFFDIHVFVNGTVLQGGQHVSMPYATRGLYLETEVGHHKLSSESYGFVARIDGSGNFQILLSDRHFNKTCGLCGDFNIFAEDDFRTQEGTLTSDPYDFANSWALSSEEQRCPRVSPPSSSCNVSSELQKGLWEKCQLLKTASVFARCHALVDPEPFVALCERMLCACAQGLRCPCPVLLEYARACAKQGMLLYGWADHSSCRPDCPAGMEYKECVSPCHRTCRSLSITEVCREQCVDGCSCPEGQLLDEGRCVESTECPCVHAGKPYPPGASLSRDCNTCICRNSQWVCSNEDCPGECLITGQSHFKSFDDRHFTFSGVCQYLLAQDCQDHSFSVVIETVQCADDPDAVCTRSVTVRLPSPHHGLLKLKHGGGVALDGQDIQIPLLQGDLRIQHTVTASLQLNFGEDLQIDWDGRGRLLLKLSPVYAGRTCGLCGNYNGNQRDDFLTPAGLVEPLVEHFGNSWKLRADCEDLQEQPSDPCSLNPRLTKFADQACAILTSPKFEACHSAVSPLPYLRNCRYDVCACSDGRDCLCDAVANYAAACARRGVHVGWREPSFCALSCTHGQVYQQCGTPCNLTCRSLSHPDEECTEVCLEGCFCPPGLFLDETGSCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCSTSGAPGSLLPEAVLSSPLSHRSKRSLSCRPPMVKVVCPADNPRAEGLECTKTCQNYDLECMSTGCVSGCLCPPGMVRHENRCVALERCPCFHQGREYAPGDRVKVDCNSCVCQDRKWNCTDHVCDASCSALGLAHYFTFDGLKYLFPGECQYVLVQDHCGSNPGTFRVLVGNEGCSVPSLKCRKRITILVEGGEIELFDGEVNVKTPMKDETHFEVVESGRYITVLLGKALSVVWDGHLAVSVFLKRTYQERVCGLCGNFDGVQNNDLTSSSLQVEENPVDFGNSWKVSPQCADTQKVGWVRLDSAPAICHDNVMKQTMVDSSCRVLTSDVFRECNRLVNPEPYLDVCIYDSCSCESIGDCSCFCDTIAAYAHECAQHGQVVTWRTATLCPQNCEERNLKESGYQCEWRYNSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVNPEDCPVCQVEGRRLASGKKVTLNPGDPEHCQICHCDGVSLTCEACKEPGGPPPTEGPVIPTTPYVEDIPEPPLHDFFCSKLLDLVFLLDGSSKLSEADFETLKAFVVGMMERLHISQKRIRVAVVEYHDGSHAYLALQDRKRPSELRRIAGQVKYAGSEVASTSEVLKYTLFQIFGRIDRPEASRVALLLTASQEPPRLARNLVRYVQGLKKKKVSVVPVGIGPHASLKQIRLIEKQAPENKAFVLSGVHELEQRMDDIVGYLCDLALEVPAPTLTQHPLAAQVTVAPQLLGPSLPGPKRSSVVLDVAFLLEGSDEVGEANFNRSAEFVEEVIRRMDVGQDGIHVTVLQYSYVVTVEHSFREPQSKDVVLQRLREVRYRGGNQTNTGLALQYLSEHSFSASQGDREQAPNLVYMVTGSPASDKIQRMPGDIQLVPIGVGPRVDVQELERVSWPQTPIFIQDFERLPREAPDLVLQRCCSEDGPHLPTLAPAPDCSQPLDVVLLLDGSSTSPASYFDEMKSFAKAFISKANLGPQLTQVSVLQYGSNTNVDVPWDIHVDKAHLLSLVDPMHREGGPSQVGQALSFAARYITSQVHGARPSASKVVVILVTGSSMDSVEAAAAAARSNRVAVFPIGIGDQYDAAQLRVLAGPGASSNVAELQRIEDLPSMVALGNSFFQRLCSGFVSVCVDEDGNERRPGDVWTLLDQCHTVTCLPDGQTLLKSHRVNCDQGPQPSCPDGQTPLRMEEACGCRWACPCVCTGSSTRHIVTFDGRNFKLTGNCSYVLFHNKEQDLEVILHNGFCSAGARQACMKSVEVKQNGLSVELRSNMEVMVNGRLVSVPYLGGDMEVRVYGTIMFEVRFMGHILSFTPQNNEFQLQLRPKIFASKTYGLCGFCDENGANDFMLRDGTVTEDWKTLVREWTVQQPGQTCPLGPEEPCPISQGSRCQVLLSELFAECHKVLAPATFHAMCQQDSCQQEQVCEAIASYAHLCRTKGVCVDWRTPDFCAVSCPPSLIYNHCESGCPRQCEGNSSSCGDHPLEGCFCPPHQVMLEGSCVPEEACTQCVGDDGIRHQLLETWVPDHQPCQICTCLSGRKVNCTTQPCPSAGVPTCGPCEVARLRQSTQQCCPEYECVCDLVSCDVPPVPNCEDGLQPVLANPGECRPSFTCVCRKEECPKGSPPSCPPHRMPALRKTRCCDEYECACNCTNSTVSCPLGYLASTITNDCSCTTTTCLPDKVCVHRGTIYPVGQFWEEGCDTCTCTDLEDAVMGLRVAQCSQKPCADICRPGFTYVLREGECCGRCLPSACEVVTGSPRGDSQTQWKSVGSHWASPENPCLIHECVRVEEEVFVQQRNVSCPQLNVPVCPLGFQLRCQTLGCCPTCRCEPVQACVLNGTIIGPGKTVMVDACMTCRCHVQAGVISGFKLECRKTTCQACPAGYMEEKLQGECCGRCLPTACTIQLRGGQIMMLKRDETLQDGCDSHFCKVNKRGEFIWEKRVMSCPPFNEHKCLAEGGEIMKIPGTCCDTCEEPECKDITARVKSIKVGDCKSEDEVDIHYCQGRCTSKALYSIDTEDVQDQCSCCSPTRTEPMPVPLRCTNGSIIHHVVLNALQCQCSSRKCSP", "length": 2813, "header": "tr|A0A3Q1LLU1-1|A0A3Q1LLU1_BOVIN Computationally mapped isoform of von Willebrand factor OS=Bos taurus OX=9913 GN=VWF PE=4 SV=2 CANONICAL=A0AAA9SUN5-1" }, "locus": { "chromosome": "5", "start_pos": 104345551, "end_pos": 104223117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069613.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069613.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060789.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060789.2" } ] } }, { "isoform_ac": "A0AAA9SUN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5/entry#A0AAA9SUN5-1", "sequence": { "sequence": "MDYSLPGSSICEDSPGKNTGMFPTRLARLLLAVALTLPGALCGEGALGKSSMARCSLFGADFINTFDESMYSFSGDCSYLLAGDCKTHSFSIVGDFQGGRRMGLSVYLGEFFDIHVFVNGTVLQGGQHVSMPYATRGLYLETEVGHHKLSSESYGFVARIDGSGNFQILLSDRHFNKTCGLCGDFNIFAEDDFRTQEGTLTSDPYDFANSWALSSEEQRCPRVSPPSSSCNVSSELQKGLWEKCQLLKTASVFARCHALVDPEPFVALCERMLCACAQGLRCPCPVLLEYARACAKQGMLLYGWADHSSCRPDCPAGMEYKECVSPCHRTCRSLSITEVCREQCVDGCSCPEGQLLDEGRCVESTECPCVHAGKPYPPGASLSRDCNTCICRNSQWVCSNEDCPGECLITGQSHFKSFDDRHFTFSGVCQYLLAQDCQDHSFSVVIETVQCADDPDAVCTRSVTVRLPSPHHGLLKLKHGGGVALDGQDIQIPLLQGDLRIQHTVTASLQLNFGEDLQIDWDGRGRLLLKLSPVYAGRTCGLCGNYNGNQRDDFLTPAGLVEPLVEHFGNSWKLRADCEDLQEQPSDPCSLNPRLTKFADQACAILTSPKFEACHSAVSPLPYLRNCRYDVCACSDGRDCLCDAVANYAAACARRGVHVGWREPSFCALSCTHGQVYQQCGTPCNLTCRSLSHPDEECTEVCLEGCFCPPGLFLDETGSCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCSTSGAPGSLLPEAVLSSPLSHRSKRSLSCRPPMVKVVCPADNPRAEGLECTKTCQNYDLECMSTGCVSGCLCPPGMVRHENRCVALERCPCFHQGREYAPGDRVKVDCNSCVCQDRKWNCTDHVCDASCSALGLAHYFTFDGLKYLFPGECQYVLVQDHCGSNPGTFRVLVGNEGCSVPSLKCRKRITILVEGGEIELFDGEVNVKTPMKDETHFEVVESGRYITVLLGKALSVVWDGHLAVSVFLKRTYQERVCGLCGNFDGVQNNDLTSSSLQVEENPVDFGNSWKVSPQCADTQKVRLDSAPAICHDNVMKQTMVDSSCRVLTSDVFRECNRLVNPEPYLDVCIYDSCSCESIGDCSCFCDTIAAYAHECAQHGQVVTWRTATLCPQNCEERNLKESGYQCEWRYNSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVNPEDCPVCQVEGRRLASGKKVTLNPGDPEHCQICHCDGVSLTCEACKEPGGPPPTEGPVIPTTPYVEDIPEPPLHDFFCSKLLDLVFLLDGSSKLSEADFETLKAFVVGMMERLHISQKRIRVAVVEYHDGSHAYLALQDRKRPSELRRIAGQVKYAGSEVASTSEVLKYTLFQIFGRIDRPEASRVALLLTASQEPPRLARNLVRYVQGLKKKKVSVVPVGIGPHASLKQIRLIEKQAPENKAFVLSGVHELEQRMDDIVGYLCDLALEVPAPTLTQHPLAAQVTVAPQLLGPSLPGPKRSSVVLDVAFLLEGSDEVGEANFNRSAEFVEEVIRRMDVGQDGIHVTVLQYSYVVTVEHSFREPQSKDVVLQRLREVRYRGGNQTNTGLALQYLSEHSFSASQGDREQAPNLVYMVTGSPASDKIQRMPGDIQLVPIGVGPRVDVQELERVSWPQTPIFIQDFERLPREAPDLVLQRCCSEDGPHLPTLAPAPDCSQPLDVVLLLDGSSTSPASYFDEMKSFAKAFISKANLGPQLTQVSVLQYGSNTNVDVPWDIHVDKAHLLSLVDPMHREGGPSQVGQALSFAARYITSQVHGARPSASKVVVILVTGSSMDSVEAAAAAARSNRVAVFPIGIGDQYDAAQLRVLAGPGASSNVAELQRIEDLPSMVALGNSFFQRLCSGFVSVCVDEDGNERRPGDVWTLLDQCHTVTCLPDGQTLLKSHRVNCDQGPQPSCPDGQTPLRMEEACGCRWACPCVCTGSSTRHIVTFDGRNFKLTGNCSYVLFHNKEQDLEVILHNGFCSAGARQACMKSVEVKQNGLSVELRSNMEVMVNGRLVSVPYLGGDMEVRVYGTIMFEVRFMGHILSFTPQNNEFQLQLRPKIFASKTYGLCGFCDENGANDFMLRDGTVTEDWKTLVREWTVQQPGQTCPLGPEEPCPISQGSRCQVLLSELFAECHKVLAPATFHAMCQQDSCQQEQVCEAIASYAHLCRTKGVCVDWRTPDFCAVSCPPSLIYNHCESGCPRQCEGNSSSCGDHPLEGCFCPPHQVMLEGSCVPEEACTQCVGDDGIRHQLLETWVPDHQPCQICTCLSGRKVNCTTQPCPSAGVPTCGPCEVARLRQSTQQCCPEYECVCDLVSCDVPPVPNCEDGLQPVLANPGECRPSFTCVCRKEECPKGSPPSCPPHRMPALRKTRCCDEYECACNCTNSTVSCPLGYLASTITNDCSCTTTTCLPDKVCVHRGTIYPVGQFWEEGCDTCTCTDLEDAVMGLRVAQCSQKPCADICRPGFTYVLREGECCGRCLPSACEVVTGSPRGDSQTQWKSVGSHWASPENPCLIHECVRVEEEVFVQQRNVSCPQLNVPVCPLGFQLRCQTLGCCPTCRCEPVQACVLNGTIIGPGKTVMVDACMTCRCHVQAGVISGFKLECRKTTCQACPAGYMEEKLQGECCGRCLPTACTIQLRGGQIMMLKRDETLQDGCDSHFCKVNKRGEFIWEKRVMSCPPFNEHKCLAEGGEIMKIPGTCCDTCEEPECKDITARVKSIKVGDCKSEDEVDIHYCQGRCTSKALYSIDTEDVQDQCSCCSPTRTEPMPVPLRCTNGSIIHHVVLNALQCQCSSRKCSP", "length": 2830, "header": "tr|A0AAA9SUN5-1|A0AAA9SUN5_BOVIN Isoform 1 of von Willebrand factor OS=Bos taurus OX=9913 GN=VWF PE=4 SV=1 CANONICAL=A0AAA9SUN5-1" }, "locus": { "chromosome": "5", "start_pos": 104345551, "end_pos": 104222279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119330.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119330.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086869.1" } ] } }, { "isoform_ac": "A0AAA9TPC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5/entry#A0AAA9TPC2-1", "sequence": { "sequence": "MGQAVGQDGKNQTQASASFLESQGLWEKCQLLKTASVFARCHALVDPEPFVALCERMLCACAQGLRCPCPVLLEYARACAKQGMLLYGWADHSSCRPDCPAGMEYKECVSPCHRTCRSLSITEVCREQCVDGCSCPEGQLLDEGRCVESTECPCVHAGKPYPPGASLSRDCNTCICRNSQWVCSNEDCPGECLITGQSHFKSFDDRHFTFSGVCQYLLAQDCQDHSFSVVIETVQCADDPDAVCTRSVTVRLPSPHHGLLKLKHGGGVALDGQDIQIPLLQGDLRIQHTVTASLQLNFGEDLQIDWDGRGRLLLKLSPVYAGRTCGLCGNYNGNQRDDFLTPAGLVEPLVEHFGNSWKLRADCEDLQEQPSDPCSLNPRLTKFADQACAILTSPKFEACHSAVSPLPYLRNCRYDVCACSDGRDCLCDAVANYAAACARRGVHVGWREPSFCALSCTHGQVYQQCGTPCNLTCRSLSHPDEECTEVCLEGCFCPPGLFLDETGSCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCSTSGAPGSLLPEAVLSSPLSHRSKRSLSCRPPMVKVVCPADNPRAEGLECTKTCQNYDLECMSTGCVSGCLCPPGMVRHENRCVALERCPCFHQGREYAPGDRVKVDCNSCVCQDRKWNCTDHVCDASCSALGLAHYFTFDGLKYLFPGECQYVLVQDHCGSNPGTFRVLVGNEGCSVPSLKCRKRITILVEGGEIELFDGEVNVKTPMKDETHFEVVESGRYITVLLGKALSVVWDGHLAVSVFLKRTYQERVCGLCGNFDGVQNNDLTSSSLQVEENPVDFGNSWKVSPQCADTQKVRLDSAPAICHDNVMKQTMVDSSCRVLTSDVFRECNRLVNPEPYLDVCIYDSCSCESIGDCSCFCDTIAAYAHECAQHGQVVTWRTATLCPQNCEERNLKESGYQCEWRYNSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVNPEDCPVCQVEGRRLASGKKVTLNPGDPEHCQICHCDGVSLTCEACKEPGGPPPTEGPVIPTTPYVEDIPEPPLHDFFCSKLLDLVFLLDGSSKLSEADFETLKAFVVGMMERLHISQKRIRVAVVEYHDGSHAYLALQDRKRPSELRRIAGQVKYAGSEVASTSEVLKYTLFQIFGRIDRPEASRVALLLTASQEPPRLARNLVRYVQGLKKKKVSVVPVGIGPHASLKQIRLIEKQAPENKAFVLSGVHELEQRMDDIVGYLCDLALEVPAPTLTQHPLAAQVTVAPQLLGPSLPGPKRSSVVLDVAFLLEGSDEVGEANFNRSAEFVEEVIRRMDVGQDGIHVTVLQYSYVVTVEHSFREPQSKDVVLQRLREVRYRGGNQTNTGLALQYLSEHSFSASQGDREQAPNLVYMVTGSPASDKIQRMPGDIQLVPIGVGPRVDVQELERVSWPQTPIFIQDFERLPREAPDLVLQRCCSEDGPHLPTLAPAPDCSQPLDVVLLLDGSSTSPASYFDEMKSFAKAFISKANLGPQLTQVSVLQYGSNTNVDVPWDIHVDKAHLLSLVDPMHREGGPSQVGQALSFAARYITSQVHGARPSASKVVVILVTGSSMDSVEAAAAAARSNRVAVFPIGIGDQYDAAQLRVLAGPGASSNVAELQRIEDLPSMVALGNSFFQRLCSGFVSVCVDEDGNERRPGDVWTLLDQCHTVTCLPDGQTLLKSHRVNCDQGPQPSCPDGQTPLRMEEACGCRWACPCVCTGSSTRHIVTFDGRNFKLTGNCSYVLFHNKEQDLEVILHNGFCSAGARQACMKSVEVKQNGLSVELRSNMEVMVNGRLVSVPYLGGDMEVRVYGTIMFEVRFMGHILSFTPQNNEFQLQLRPKIFASKTYGLCGFCDENGANDFMLRDGTVTEDWKTLVREWTVQQPGQTCPLGPEEPCPISQGSRCQVLLSELFAECHKVLAPATFHAMCQQDSCQQEQVCEAIASYAHLCRTKGVCVDWRTPDFCAVSCPPSLIYNHCESGCPRQCEGNSSSCGDHPLEGCFCPPHQVMLEGSCVPEEACTQCVGDDGIRHQLLETWVPDHQPCQICTCLSGRKVNCTTQPCPSAGVPTCGPCEVARLRQSTQQCCPEYECVCDLVSCDVPPVPNCEDGLQPVLANPGECRPSFTCVCRKEECPKGSPPSCPPHRMPALRKTRCCDEYECACNCTNSTVSCPLGYLASTITNDCSCTTTTCLPDKVCVHRGTIYPVGQFWEEGCDTCTCTDLEDAVMGLRVAQCSQKPCADICRPGFTYVLREGECCGRCLPSACEVVTGSPRGDSQTQWKSVGSHWASPENPCLIHECVRVEEEVFVQQRNVSCPQLNVPVCPLGFQLRCQTLGCCPTCRCEPVQACVLNGTIIGPGKTVMVDACMTCRCHVQAGVISGFKLECRKTTCQACPAGYMEEKLQGECCGRCLPTACTIQLRGGQIMMLKRDETLQDGCDSHFCKVNKRGEFIWEKRVMSCPPFNEHKCLAEGGEIMKIPGTCCDTCEEPECKDITARVKSIKVGDCKSEDEVDIHYCQGRCTSKALYSIDTEDVQDQCSCCSPTRTEPMPVPLRCTNGSIIHHVVLNALQCQCSSRKCSP", "length": 2615, "header": "tr|A0AAA9TPC2-1|A0AAA9TPC2_BOVIN Computationally mapped isoform of von Willebrand factor OS=Bos taurus OX=9913 GN=VWF PE=4 SV=1 CANONICAL=A0AAA9SUN5-1" }, "locus": { "chromosome": "5", "start_pos": 104345551, "end_pos": 104248431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135100.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135100.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098868.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098868.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1265, "start_aa": "Thr", "end_pos": 1265, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1265", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-354192", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-354192", "resource": "Reactome", "description": "Integrin signaling" }, { "id": "R-BTA-354194", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-354194", "resource": "Reactome", "description": "GRB2:SOS provides linkage to MAPK signaling for Integrins" }, { "id": "R-BTA-372708", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-372708", "resource": "Reactome", "description": "p130Cas linkage to MAPK signaling for integrins" }, { "id": "R-BTA-430116", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430116", "resource": "Reactome", "description": "GP1b-IX-V activation signalling" }, { "id": "R-BTA-5674135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "resource": "Reactome", "description": "MAP2K and MAPK activation" }, { "id": "R-BTA-9769735", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769735", "resource": "Reactome", "description": "Initiation of coagulation cascade" }, { "id": "R-BTA-9769739", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "resource": "Reactome", "description": "Regulation of clotting cascade" }, { "id": "R-BTA-9769743", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769743", "resource": "Reactome", "description": "Amplification and propagation of coagulation cascade" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "immunoglobulin binding", "id": "GO:0019865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "Weibel-Palade body", "id": "GO:0033093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033093", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "platelet activation", "id": "GO:0030168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "cell-substrate adhesion", "id": "GO:0031589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "positive regulation of intracellular signal transduction", "id": "GO:1902533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902533", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1534, "end_pos": 1536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1593, "end_pos": 1595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1990, "end_pos": 1992, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2240, "end_pos": 2242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2307, "end_pos": 2309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2414, "end_pos": 2416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2417, "end_pos": 2419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2563, "end_pos": 2565, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2602, "end_pos": 2604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2807, "end_pos": 2809, "annotation": "n_glycosylation_sequon" }, { "start_pos": 685, "end_pos": 687, "annotation": "n_glycosylation_sequon" }, { "start_pos": 876, "end_pos": 878, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" }, { "id": "PS01225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTCK", "eco_id": "ECO_0000259", "start_pos": 2741, "end_pos": 2829, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 1294, "end_pos": 1470, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 2272, "end_pos": 2345, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN5" }, { "id": "PS51233", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51233" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFD", "eco_id": "ECO_0000259", "start_pos": 53, "end_pos": 221, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1265 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 1534, "end_pos": 1536 }, { "start_pos": 1593, "end_pos": 1595 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 1990, "end_pos": 1992 }, { "start_pos": 2240, "end_pos": 2242 }, { "start_pos": 2307, "end_pos": 2309 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 2414, "end_pos": 2416 }, { "start_pos": 2417, "end_pos": 2419 }, { "start_pos": 2563, "end_pos": 2565 }, { "start_pos": 2602, "end_pos": 2604 }, { "start_pos": 2807, "end_pos": 2809 }, { "start_pos": 685, "end_pos": 687 }, { "start_pos": 876, "end_pos": 878 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW12-1", "uniprot_ac": "A0AAA9SW12", "uniprot_id": "A0AAA9SW12_BOVIN", "mass": { "chemical_mass": 53204.0, "monoisotopic_mass": 53204.0 }, "refseq": { "ac": "XP_015313700", "name": "gastric inhibitory polypeptide receptor isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313700" }, "gene_names": [ { "name": "GIPR", "type": "recommended", "evidence": [ { "id": "A0AAA9SW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ] }, { "name": "GIPR", "type": "synonym", "evidence": [ { "id": "XP_015313700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313700" } ] } ], "protein_names": [ { "name": "Gastric inhibitory polypeptide receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12/entry#names_and_taxonomy" } ] }, { "name": "Glucose-dependent insulinotropic polypeptide receptor", "type": "synonym", "evidence": [ { "id": "A0AAA9SW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12/entry#names_and_taxonomy" } ] }, { "name": "gastric inhibitory polypeptide receptor isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015313700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313700" } ] } ], "function": [ { "annotation": "This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.", "evidence": [ { "database": "UniProtKB", "id": "E1B8G5", "url": "https://www.uniprot.org/uniprotkb/E1B8G5#function" }, { "database": "UniProtKB", "id": "ARBA00059971", "url": "https://www.uniprot.org/uniprotkb/ARBA00059971#function" }, { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIPR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12", "locus": { "chromosome": "18", "start_pos": 53249703, "end_pos": 53241187, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005527", "url": "https://www.ensembl.org/id/ENSBTAG00000005527" } ] } } ], "crossref": [ { "id": "A0AAA9SW12", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005527", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005527", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15929", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15929", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617879", "url": "https://www.ncbi.nlm.nih.gov/gene/617879", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LNCPPWR", "url": "https://omabrowser.org/oma/group/LNCPPWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8G5", "url": "https://www.orthodb.org/?gene=E1B8G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015313700", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313700", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8G5", "url": "https://www.uniprot.org/uniprotkb/E1B8G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8G5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTCPPWWLLLLLSLWEPLLRSAEAGSEGQTAGELYQRWERYRRECQETLEASEPPAGLACNGSFDMYVCWDYTAPNATARASCPWYLPWHGHVAKGFVLRQCGSDGQWGPWRDHSQCENPEKNGVFQDQRLTLERLQVVYTVGYSLSLATLLFALLILSTFRRLRCTRNYIHINLFTSFMLRAAAILTRDRLLPPPGPYPGDQVLTLWNQALVACRTAQIVTQYCVGANYTWLLVEGIYLHSLLVLVGGSEKGHFRCYMLLGWGAPTLFVIPWVIVRYLFENTQCWERNDIKAIWWIIRTPILLTILINFLIFVRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRLAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHRCRLRHSLSEEPRQRPEPVFRTLPSGSGPGQVASGRALCSRTLPGPGGEANHVLESYC", "length": 466, "header": "tr|A0AAA9SW12-1|A0AAA9SW12_BOVIN Isoform 1 of Gastric inhibitory polypeptide receptor OS=Bos taurus OX=9913 GN=GIPR PE=3 SV=1 CANONICAL=A0AAA9SW12-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12/entry#A0AAA9SW12-1", "sequence": { "sequence": "MPTCPPWWLLLLLSLWEPLLRSAEAGSEGQTAGELYQRWERYRRECQETLEASEPPAGLACNGSFDMYVCWDYTAPNATARASCPWYLPWHGHVAKGFVLRQCGSDGQWGPWRDHSQCENPEKNGVFQDQRLTLERLQVVYTVGYSLSLATLLFALLILSTFRRLRCTRNYIHINLFTSFMLRAAAILTRDRLLPPPGPYPGDQVLTLWNQALVACRTAQIVTQYCVGANYTWLLVEGIYLHSLLVLVGGSEKGHFRCYMLLGWGAPTLFVIPWVIVRYLFENTQCWERNDIKAIWWIIRTPILLTILINFLIFVRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRLAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHRCRLRHSLSEEPRQRPEPVFRTLPSGSGPGQVASGRALCSRTLPGPGGEANHVLESYC", "length": 466, "header": "tr|A0AAA9SW12-1|A0AAA9SW12_BOVIN Isoform 1 of Gastric inhibitory polypeptide receptor OS=Bos taurus OX=9913 GN=GIPR PE=3 SV=1 CANONICAL=A0AAA9SW12-1" }, "locus": { "chromosome": "18", "start_pos": 53249604, "end_pos": 53241345, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106731.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106731.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088206.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088206.1" } ] } }, { "isoform_ac": "A0AAA9TH61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12/entry#A0AAA9TH61-1", "sequence": { "sequence": "MPTCPPWWLLLLLSLWEPLLRSAEAGSEGQTAGELYQRWERYRRECQETLEASEPPAVAKGFVLRQCGSDGQWGPWRDHSQCENPEKNGVFQDQRLTLERLQVVYTVGYSLSLATLLFALLILSTFRRLRCTRNYIHINLFTSFMLRAAAILTRDRLLPPPGPYPGDQVLTLWNQALVACRTAQIVTQYCVGANYTWLLVEGIYLHSLLVLVGGSEKGHFRCYMLLGWGAPTLFVIPWVIVRYLFENTQCWERNDIKAIWWIIRTPILLTILINFLIFVRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRLAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHRCRLRHSLSEEPRQRPEPVFRTLPSGSGPGQVASGRALCSRTLPGPGGEANHVLESYC", "length": 430, "header": "tr|A0AAA9TH61-1|A0AAA9TH61_BOVIN Computationally mapped isoform of Gastric inhibitory polypeptide receptor OS=Bos taurus OX=9913 GN=GIPR PE=3 SV=1 CANONICAL=A0AAA9SW12-1" }, "locus": { "chromosome": "18", "start_pos": 53249604, "end_pos": 53241345, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100362.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100362.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097861.1" } ] } }, { "isoform_ac": "E1B8G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12/entry#E1B8G5-1", "sequence": { "sequence": "MPTCPPWWLLLLLSLWEPLLRSAEAGSEGQTAGELYQRWERYRRECQETLEASEPPAGLACNGSFDMYVCWDYTAPNATARASCPWYLPWHGHVAKGFVLRQCGSDGQWGPWRDHSQCENPEKNGVFQDQRLTLERLQVVYTVGYSLSLATLLFALLILSTFRRLRCTRNYIHINLFTSFMLRAAAILTRDRLLPPPGPYPGDQVLTLWNQALVACRTAQIVTQYCVGANYTWLLVEGIYLHSLLVLVGGSEKGHFRCYMLLGWGAPTLFVIPWVIVRYLFENTQCWERNDIKAIWWIIRTPILLTILINFLIFVRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRLAKLGFEIFLSSFQGFLVSVLYCFINKEVGRAAAAAPALCRPRREWRARRRL", "length": 422, "header": "tr|E1B8G5-1|E1B8G5_BOVIN Computationally mapped isoform of Gastric inhibitory polypeptide receptor OS=Bos taurus OX=9913 GN=GIPR PE=3 SV=2 CANONICAL=A0AAA9SW12-1" }, "locus": { "chromosome": "18", "start_pos": 53249380, "end_pos": 53241345, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007271.4", "url": "https://www.ensembl.org/id/ENSBTAT00000007271.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007271.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007271.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-420092", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "resource": "Reactome", "description": "Glucagon-type ligand receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QV54-1", "protein_name": "Gastric inhibitory polypeptide receptor", "gene_name": "GIPR", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNCPPRRLLLLLLLCGPLLRRAEAGSEGQTAGELYQRWERYRRECQETLQAADPLPGLACNGSFDMYVCWDYTAPNATARASCPWYLPWHRHVASGFVLRHCGSDGQWGPWRDHSQCEDPEKNGAFQDQRLILERLQVVYTVGYSLSLATLLLALLILSFFRRLRCTRNYIHINLFTSFMLRAAAILTRDRLLPPPGPYSGDGAPVLWNQALAACRTAQIVTQYCVGANYTWLLVEGIYLHSLLVLVGGSEEGHFRCYMLLGWGAPALFVIPWVIVRYLYEDTQCWERNDIKAIWWIIRTPILLTILINFLIFIRILGILLSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRLAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHRCRLRHSLDEEPRQPRERAFQTLRLGSGHGQVPAGRSPCSRTLPGPGDEASHILESYC", "length": 466 }, "evidence": [ { "id": "A0AAA9SW12", "url": "https://omabrowser.org/oma/group/A0AAA9SW12/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P43219-1", "protein_name": "Gastric inhibitory polypeptide receptor", "gene_name": "Gipr", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLRLLLLLLWLWGLSLQRAETDSEGQTTGELYQRWERYGWECQNTLEATEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWYRQVAAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQKLILERLQVVYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRAGAILTRDQLLPPLGPYTGNQTPTLWNQALAACRTAQILTQYCVGANYTWLLVEGVYLHHLLVVVRRSEKGHFRCYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILITILINFLIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLMPLLGVHEVVFAPVTEEQAEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRRLRLSLQEQCPRPHLGQAPRAVPLSSAPQEAAIRNALPSGMLHVPGDEVLESYC", "length": 455 }, "evidence": [ { "id": "A0AAA9SW12", "url": "https://omabrowser.org/oma/group/A0AAA9SW12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P48546-1", "protein_name": "Gastric inhibitory polypeptide receptor", "gene_name": "GIPR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC", "length": 466 }, "evidence": [ { "id": "A0AAA9SW12", "url": "https://omabrowser.org/oma/group/A0AAA9SW12/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q0P543-1", "protein_name": "Gastric inhibitory polypeptide receptor", "gene_name": "Gipr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLRLLLLLLWLWGLQWAETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQTLILERLQIMYTVGYSLSLTTLLLALLILSLFRRLHCTRNYIHMNLFTSFMLRAAAILTRDQLLPPLGPYTGDQAPTPWNQALAACRTAQIMTQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCYLLLGWGAPALFVIPWVIVRYLRENTQCWERNEVKAIWWIIRTPILITILINFLIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQVEGSLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRQGWRHRRLRLSLQEQRPRPHQELAPRAVPLSSACREAAVGNALPSGMLHVPGDEVLESYC", "length": 460 }, "evidence": [ { "id": "A0AAA9SW12", "url": "https://omabrowser.org/oma/group/A0AAA9SW12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" }, { "name": "regulation of insulin secretion", "id": "GO:0050796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "gastric inhibitory peptide receptor activity", "id": "GO:0016519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016519", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" }, { "name": "glucagon family peptide binding", "id": "GO:0120022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" }, { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" }, { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" }, { "id": "PS50227", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50227" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 1", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 122, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SW12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW12" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 137, "end_pos": 396, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 230, "end_pos": 232 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STY5-1", "uniprot_ac": "A0AAA9STY5", "uniprot_id": "A0AAA9STY5_BOVIN", "mass": { "chemical_mass": 53847.0, "monoisotopic_mass": 53847.0 }, "refseq": {}, "gene_names": [ { "name": "CDSN", "type": "recommended", "evidence": [ { "id": "A0AAA9STY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ] } ], "protein_names": [ { "name": "Corneodesmosin", "type": "recommended", "evidence": [ { "id": "A0AAA9STY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Important for the epidermal barrier integrity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ5#function" }, { "database": "UniProtKB", "id": "ARBA00004080", "url": "https://www.uniprot.org/uniprotkb/ARBA00004080#function" }, { "database": "UniProtKB", "id": "A0AAA9S289", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S289#function" }, { "database": "UniProtKB", "id": "A0AAA9SAR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR0#function" }, { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5#function" }, { "database": "UniProtKB", "id": "A0AAA9SXT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT1#function" }, { "database": "UniProtKB", "id": "A0AAA9TMS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS7#function" }, { "database": "UniProtKB", "id": "A0AAA9TZI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI7#function" }, { "database": "UniProtKB", "id": "F1MWJ0", "url": "https://www.uniprot.org/uniprotkb/F1MWJ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDSN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5", "locus": { "chromosome": "23", "start_pos": 28026890, "end_pos": 28019813, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021721", "url": "https://www.ensembl.org/id/ENSBTAG00000021721" } ] } } ], "crossref": [ { "id": "A0AAA9STY5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021721", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MWJ0", "url": "https://www.orthodb.org/?gene=F1MWJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23207:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23207:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S289", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S289", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S289-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S289-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWJ0", "url": "https://www.uniprot.org/uniprotkb/F1MWJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWJ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MWJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAEDSVDSAGLGRDQGRRQRKGQRSPGLQGNSCLWTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 566, "header": "tr|A0AAA9STY5-1|A0AAA9STY5_BOVIN Isoform 1 of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S289-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9S289-1", "sequence": { "sequence": "GLSLEAAPHCLGTSGTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 545, "header": "tr|A0AAA9S289-1|A0AAA9STY5_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28021643, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120624.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120624.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079152.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079152.1" } ] } }, { "isoform_ac": "A0AAA9SAR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9SAR0-1", "sequence": { "sequence": "GTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 531, "header": "tr|A0AAA9SAR0-1|A0AAA9STY5_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28021433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132392.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132392.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083179.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083179.1" } ] } }, { "isoform_ac": "A0AAA9STY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9STY5-1", "sequence": { "sequence": "MVAEDSVDSAGLGRDQGRRQRKGQRSPGLQGNSCLWTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 566, "header": "tr|A0AAA9STY5-1|A0AAA9STY5_BOVIN Isoform 1 of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28020070, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102262.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102262.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087463.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087463.1" } ] } }, { "isoform_ac": "A0AAA9SXT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9SXT1-1", "sequence": { "sequence": "EAHALQLEKAHTQQQRPSVANSKSIFKRFDPSNHSSPISHAQWPQLGTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 577, "header": "tr|A0AAA9SXT1-1|A0AAA9SXT1_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28019887, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117534.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117534.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088877.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088877.1" } ] } }, { "isoform_ac": "A0AAA9TFQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9TFQ5-1", "sequence": { "sequence": "MGSSRASQIGCVGGRGVLALLLAGLLLQGTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQTPSQSSTQMLRTLRWGDTRLSAETGTASLLSLGPAQMFQ", "length": 574, "header": "tr|A0AAA9TFQ5-1|A0AAA9STY5_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025886, "end_pos": 28021405, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089339.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089339.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097393.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097393.1" } ] } }, { "isoform_ac": "A0AAA9TMS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9TMS7-1", "sequence": { "sequence": "DLLFPLCKGGHRAWRAEETGSRLQIRRQLSWAPNPRLGTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 568, "header": "tr|A0AAA9TMS7-1|A0AAA9TMS7_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28022132, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099820.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099820.1" } ] } }, { "isoform_ac": "A0AAA9TZI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#A0AAA9TZI7-1", "sequence": { "sequence": "ECGRHGTWAVTAGGGEGGGDWKLSDGSPGKSRIQELWVGSQVGQGLQPVPEGKLKCPHLCVERGRGVRHANTGEGRRVREPGTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 612, "header": "tr|A0AAA9TZI7-1|A0AAA9TZI7_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=1 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28020819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125602.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125602.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102988.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102988.1" } ] } }, { "isoform_ac": "F1MWJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5/entry#F1MWJ0-1", "sequence": { "sequence": "AQTDCFSSSRPHQLPPGTLAKSIGTFLDPCKDPTRITSPNDPCLLGKGGSSSSSGGSSGSSGGGSSGSSSGSSGSSSSSSGVSSGLSGHPSGGSSGSSSGSNVSSGPSGSSSGSSGVSSGLSGRPSGGYSGSSSGVSSSASGSGSTGSIVAHGGSSGSSLFKPGTGYSQISYSSGSGSSLQGASSSLPSGSISSPSGGGLSSSGSQTSWLSSSGGQKVSSKLRPCGPDIPDSPCSGGPIVSHSGPYISSSHSVSGGQRPVVVVVEQHGSGGPGGPGVGQRVPCLNGGPPGKPCPPITSVDQYGSYEVVGGSSNSYLVPGMTYSGGKIYPVGYFTKEGPIKGSPGVPSFAAGPPISEGKYFSGNPIIPSHSSSSSNIYQSGASSTVVFQPVGSGGVQPCVVGSSGSKGPCSLSSSGVSSSSSISSSSSSSFHPCGGVSQGPCSPPGTGSLSGSSSSLSGGKIILQPCGSKSSAPGHPCISVSSSTLSGGPNGSPQPDPSAGAKPCGPGNSGKTPCRSIRDILAQVKPLGPQLADPEVFLPQGDLPNSS", "length": 547, "header": "tr|F1MWJ0-1|F1MWJ0_BOVIN Computationally mapped isoform of Corneodesmosin OS=Bos taurus OX=9913 GN=CDSN PE=4 SV=2 CANONICAL=A0AAA9STY5-1" }, "locus": { "chromosome": "23", "start_pos": 28025145, "end_pos": 28021232, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028955.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028955.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028955.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028955.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" }, { "name": "cornified envelope", "id": "GO:0001533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001533", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "skin morphogenesis", "id": "GO:0043589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" }, { "name": "amyloid fibril formation", "id": "GO:1990000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" }, { "name": "corneocyte desquamation", "id": "GO:0003336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" }, { "name": "negative regulation of cornification", "id": "GO:1905716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905716", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 564, "end_pos": 566, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 509, "end_pos": 511 }, { "start_pos": 564, "end_pos": 566 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STB0-1", "uniprot_ac": "A0AAA9STB0", "uniprot_id": "A0AAA9STB0_BOVIN", "mass": { "chemical_mass": 29896.0, "monoisotopic_mass": 29896.0 }, "refseq": { "ac": "XP_024840688", "name": "monocyte to macrophage differentiation factor 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840688" }, "gene_names": [ { "name": "MMD2", "type": "recommended", "evidence": [ { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ] }, { "name": "MMD2", "type": "synonym", "evidence": [ { "id": "XP_024840688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840688" } ] } ], "protein_names": [ { "name": "Monocyte to macrophage differentiation associated 2", "type": "synonym", "evidence": [ { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0/entry#names_and_taxonomy" } ] }, { "name": "monocyte to macrophage differentiation factor 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024840688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840688" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MMD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0", "locus": { "chromosome": "25", "start_pos": 39127923, "end_pos": 39065693, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021913", "url": "https://www.ensembl.org/id/ENSBTAG00000021913" } ] } } ], "crossref": [ { "id": "A0AAA9STB0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021913", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021913", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525334", "url": "https://www.ncbi.nlm.nih.gov/gene/525334", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005744", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005744", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20855", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20855", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20855:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20855:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03006", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03006", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840688", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840688", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFAPRLLDFQKTKYARFMNHRVPAHKRYQPTEYEHAANCATHALWIIPSILGSSNLYFLSDDDWEAISAWIYGLGLCGLFVVSTVFHTISWKKSHLRTVEHCLHMSDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTVYVFFFHERYKLVELLCYVIMGFFPALVVLSMPNTEGIWELVTGGVFYCLGMVFFKSDGRIPFAHAIWHLFVAFGAGTHYYAIWRFKCKKGVSGPGPVSVPLPKCSQATSNQD", "length": 260, "header": "tr|A0AAA9STB0-1|A0AAA9STB0_BOVIN Isoform 1 of Monocyte to macrophage differentiation associated 2 OS=Bos taurus OX=9913 GN=MMD2 PE=3 SV=2 CANONICAL=A0AAA9STB0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0/entry#A0A3Q1LS14-1", "sequence": { "sequence": "MFAPRLLDFQKTKYARFMNHRVPAHKRYQPTEYEHAANCATHALWIIPSILGSSNLYFLSDDDWEAISAWIYGLGLCGLFVVSTVFHTISWKKSHLRTVEHCLHMSDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTVYVFFFHERYKLVELLCYVIMGFFPALVVLSMMVRLGVHVTRLPRQ", "length": 193, "header": "tr|A0A3Q1LS14-1|A0AAA9STB0_BOVIN Computationally mapped isoform of Monocyte to macrophage differentiation associated 2 OS=Bos taurus OX=9913 GN=MMD2 PE=3 SV=2 CANONICAL=A0AAA9STB0-1" }, "locus": { "chromosome": "25", "start_pos": 39115689, "end_pos": 39065742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077874.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077874.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059809.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059809.2" } ] } }, { "isoform_ac": "A0AAA9STB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0/entry#A0AAA9STB0-1", "sequence": { "sequence": "MFAPRLLDFQKTKYARFMNHRVPAHKRYQPTEYEHAANCATHALWIIPSILGSSNLYFLSDDDWEAISAWIYGLGLCGLFVVSTVFHTISWKKSHLRTVEHCLHMSDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASVGTVYVFFFHERYKLVELLCYVIMGFFPALVVLSMPNTEGIWELVTGGVFYCLGMVFFKSDGRIPFAHAIWHLFVAFGAGTHYYAIWRFKCKKGVSGPGPVSVPLPKCSQATSNQD", "length": 260, "header": "tr|A0AAA9STB0-1|A0AAA9STB0_BOVIN Isoform 1 of Monocyte to macrophage differentiation associated 2 OS=Bos taurus OX=9913 GN=MMD2 PE=3 SV=2 CANONICAL=A0AAA9STB0-1" }, "locus": { "chromosome": "25", "start_pos": 39127555, "end_pos": 39065742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092409.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092409.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087374.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087374.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of Ras protein signal transduction", "id": "GO:0046579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046579", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" }, { "name": "positive regulation of neuron differentiation", "id": "GO:0045666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045666", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" }, { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" }, { "name": "pore-forming activity", "id": "GO:0140911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0#function" }, { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" }, { "id": "PIRSR604254-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604254-1" } ], "binding_site_uniprot": 212, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 212, "end_pos": 212, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0#function" }, { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" }, { "id": "PIRSR604254-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604254-1" } ], "binding_site_uniprot": 216, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 216, "end_pos": 216, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0#function" }, { "id": "A0AAA9STB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB0" }, { "id": "PIRSR604254-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR604254-1" } ], "binding_site_uniprot": 87, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 87, "end_pos": 87, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV95-1", "uniprot_ac": "A0AAA9SV95", "uniprot_id": "A0AAA9SV95_BOVIN", "mass": { "chemical_mass": 32125.0, "monoisotopic_mass": 32125.0 }, "refseq": {}, "gene_names": [ { "name": "RAB34", "type": "recommended", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ], "protein_names": [ { "name": "Ras-related protein Rab-36", "type": "recommended", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95#function" }, { "database": "UniProtKB", "id": "ARBA00058763", "url": "https://www.uniprot.org/uniprotkb/ARBA00058763#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95", "locus": { "chromosome": "19", "start_pos": 20140213, "end_pos": 20144456, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046129", "url": "https://www.ensembl.org/id/ENSBTAG00000046129" } ] } } ], "crossref": [ { "id": "A0AAA9SV95", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV95", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046129", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046129", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LX70", "url": "https://www.orthodb.org/?gene=A0A3Q1LX70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N0B5", "url": "https://www.orthodb.org/?gene=G3N0B5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27509", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27509", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8873719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LX70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0G7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0G7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0B5", "url": "https://www.uniprot.org/uniprotkb/G3N0B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0B5-1", "url": "https://www.uniprot.org/uniprotkb/G3N0B5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSDRRFPFTSSAGAPRKDAGKMNILAPVRRDRVLTKLPQCLRKEAALHVHKDFQPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSVSVPVVGEDFTSRQGKPHAQHLTLTFLQTPAQYILMEKDALKVAQEMKAEYWAVSSLTGESEAPGLPACLASHSYTSSCAPRPGTTLELLSAPCVR", "length": 290, "header": "tr|A0AAA9SV95-1|A0AAA9SV95_BOVIN Isoform 1 of Ras-related protein Rab-36 OS=Bos taurus OX=9913 GN=RAB34 PE=3 SV=2 CANONICAL=A0AAA9SV95-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#A0A3Q1LX70-1", "sequence": { "sequence": "MNILAPVRRDRVLTKLPQCLRKEAALHVHKDFQPRVTCACQEHRTGTVGRFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYILMEKDALKVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEVNVLAELEKSGSRRIGDVVRINSDDSNLYLTASKKKPTCCP", "length": 260, "header": "tr|A0A3Q1LX70-1|A0AAA9SV95_BOVIN Computationally mapped isoform of Ras-related protein Rab-36 OS=Bos taurus OX=9913 GN=RAB34 PE=3 SV=2 CANONICAL=A0AAA9SV95-1" }, "locus": { "chromosome": "19", "start_pos": 20143386, "end_pos": 20140557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080137.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080137.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065336.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065336.2" } ] } }, { "isoform_ac": "A0AAA9SF57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#A0AAA9SF57-1", "sequence": { "sequence": "MVGPPQPRVVVGSPRPRVIVGTIRPRVIVGSARTRVPPDGTPRPHLEAEGSPRPRVVLGTPRARVIVGSPRPPVIVSSPWPAVVVASRRPRAPVGSPWPRVIVGTPRSRVIVGSPRARVAGAHQASAPSQGAPQGRRQDEHSGAGAEGPRPDEAAPADLRSPRSLWWATCQWGRLVSLIGSAKTHLIRTTRPPSEWTLRWNDLRCWVSRSVCSSGTPLDRRGSSASHQPTTEELKPSSLSSTLMMWPPWSIPSSG", "length": 255, "header": "tr|A0AAA9SF57-1|A0AAA9SV95_BOVIN Computationally mapped isoform of Ras-related protein Rab-36 OS=Bos taurus OX=9913 GN=RAB34 PE=3 SV=1 CANONICAL=A0AAA9SV95-1" }, "locus": { "chromosome": "19", "start_pos": 20143801, "end_pos": 20141172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114251.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114251.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084801.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084801.1" } ] } }, { "isoform_ac": "A0AAA9SV95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#A0AAA9SV95-1", "sequence": { "sequence": "MLRSDRRFPFTSSAGAPRKDAGKMNILAPVRRDRVLTKLPQCLRKEAALHVHKDFQPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSVSVPVVGEDFTSRQGKPHAQHLTLTFLQTPAQYILMEKDALKVAQEMKAEYWAVSSLTGESEAPGLPACLASHSYTSSCAPRPGTTLELLSAPCVR", "length": 290, "header": "tr|A0AAA9SV95-1|A0AAA9SV95_BOVIN Isoform 1 of Ras-related protein Rab-36 OS=Bos taurus OX=9913 GN=RAB34 PE=3 SV=2 CANONICAL=A0AAA9SV95-1" }, "locus": { "chromosome": "19", "start_pos": 20144257, "end_pos": 20140810, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126180.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126180.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089253.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089253.2" } ] } }, { "isoform_ac": "A0AAA9U0G7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#A0AAA9U0G7-1", "sequence": { "sequence": "MNILAPVRRDRVLTKLPQCLRKEAALHVHKDFQPRVTCACQEHRTGTVGFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYILMEKDALKVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEVNVLAELEKSGSRRIGDVVRINSDDSNLYLTASKKKPTCCP", "length": 237, "header": "tr|A0AAA9U0G7-1|A0AAA9U0G7_BOVIN Computationally mapped isoform of RAB34, member RAS onco family OS=Bos taurus OX=9913 GN=RAB34 PE=4 SV=1 CANONICAL=A0AAA9SV95-1" }, "locus": { "chromosome": "19", "start_pos": 20143386, "end_pos": 20140557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102561.1" } ] } }, { "isoform_ac": "G3N0B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95/entry#G3N0B5-1", "sequence": { "sequence": "MVGPPQPRVVVGSPRPRVIVGTIRPRVIVGSARTRVPPDGTPRPHLEAEGSPRPRVVLGTPRARVIVGSPRPPVIVSSPWPAVVVASRRPRAPVGSPWPRVIVGTPRSRVIVGSPRARVAGAHQASAPSQGAPQGRRQDEHSGAGAEGPRPDEAAPGSAKTHLIRTTRPPSEWTLRWNDLRCWVSRSVCSSGTPLDRRGSSASHQPTTEELKPSSLSSTLMMWPPWSIPSSG", "length": 232, "header": "tr|G3N0B5-1|G3N0B5_BOVIN Computationally mapped isoform of RAB34, member RAS onco family OS=Bos taurus OX=9913 GN=RAB34 PE=4 SV=3 CANONICAL=A0AAA9SV95-1" }, "locus": { "chromosome": "19", "start_pos": 20143801, "end_pos": 20141172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065092.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065092.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055272.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055272.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-8873719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "resource": "Reactome", "description": "RAB geranylgeranylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "GTP-dependent protein binding", "id": "GO:0030742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030742", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "phagocytic vesicle membrane", "id": "GO:0030670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030670", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "Golgi cisterna", "id": "GO:0031985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031985", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "Golgi to plasma membrane protein transport", "id": "GO:0043001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043001", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "phagosome-lysosome fusion", "id": "GO:0090385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090385", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" }, { "name": "antigen processing and presentation", "id": "GO:0019882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-BTA-8870466", "name": "RGGT:CHM binds RABs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870466" } ] }, { "id": "R-BTA-8870469", "name": "RGGT geranylgeranylates RAB proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1131164" ], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870469", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870469" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1131164", "participant_name": "geranylgeranyl diphosphate [cytosol]", "crossref": [ { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000012495043", "database": "ZINC", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1MWA3", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVL5-1", "uniprot_ac": "A0AAA9SVL5", "uniprot_id": "A0AAA9SVL5_BOVIN", "mass": { "chemical_mass": 58983.0, "monoisotopic_mass": 58983.0 }, "refseq": {}, "gene_names": [ { "name": "MITF", "type": "recommended", "evidence": [ { "id": "A0AAA9SVL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ] } ], "protein_names": [ { "name": "Melanocyte inducing transcription factor", "type": "synonym", "evidence": [ { "id": "A0AAA9SVL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MITF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5", "locus": { "chromosome": "22", "start_pos": 31616846, "end_pos": 31857969, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006679", "url": "https://www.ensembl.org/id/ENSBTAG00000006679" } ] } } ], "crossref": [ { "id": "A0AAA9SVL5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006679", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006679", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18926", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18926", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "407219", "url": "https://www.ncbi.nlm.nih.gov/gene/407219", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCQ1", "url": "https://www.orthodb.org/?gene=A0A3Q1MCQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MKP6", "url": "https://www.orthodb.org/?gene=A0A3Q1MKP6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MCS8", "url": "https://www.orthodb.org/?gene=F1MCS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45776", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45776", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45776:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45776:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11851", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11851", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15951", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15951", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232118", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9824594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9824594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9856649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCQ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKP6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS52", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS52-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8D0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCS8", "url": "https://www.uniprot.org/uniprotkb/F1MCS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCS8-1", "url": "https://www.uniprot.org/uniprotkb/F1MCS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQVPGVHRVEELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 528, "header": "tr|A0AAA9SVL5-1|A0AAA9SVL5_BOVIN Isoform 1 of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0A3Q1LXI4-1", "sequence": { "sequence": "MWQLLSSSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 492, "header": "tr|A0A3Q1LXI4-1|A0AAA9SVL5_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31816542, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076082.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076082.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061916.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061916.2" } ] } }, { "isoform_ac": "A0A3Q1MCQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0A3Q1MCQ1-1", "sequence": { "sequence": "MEALRVQMFMPCSFESFYLSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 504, "header": "tr|A0A3Q1MCQ1-1|A0A3Q1MCQ1_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31720946, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070573.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070573.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068639.1" } ] } }, { "isoform_ac": "A0A3Q1MKP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0A3Q1MKP6-1", "sequence": { "sequence": "MGHCENTGMIFSEAVFSLWEKATMELTLCQSSRSSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 519, "header": "tr|A0A3Q1MKP6-1|A0A3Q1MKP6_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=2 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31821663, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067269.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067269.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069811.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069811.2" } ] } }, { "isoform_ac": "A0A3Q1MS52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0A3Q1MS52-1", "sequence": { "sequence": "SSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 485, "header": "tr|A0A3Q1MS52-1|A0AAA9SVL5_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31708295, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066447.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066447.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072769.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072769.2" } ] } }, { "isoform_ac": "A0AAA9SVL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0AAA9SVL5-1", "sequence": { "sequence": "MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQVPGVHRVEELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 528, "header": "tr|A0AAA9SVL5-1|A0AAA9SVL5_BOVIN Isoform 1 of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31843351, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109509.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109509.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089360.1" } ] } }, { "isoform_ac": "A0AAA9T1Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0AAA9T1Y0-1", "sequence": { "sequence": "MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 495, "header": "tr|A0AAA9T1Y0-1|A0AAA9T1Y0_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31843351, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092799.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092799.1" } ] } }, { "isoform_ac": "A0AAA9T8D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#A0AAA9T8D0-1", "sequence": { "sequence": "MEYSSEEHPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 488, "header": "tr|A0AAA9T8D0-1|A0AAA9T8D0_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=1 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31857701, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120438.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120438.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092109.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092109.1" } ] } }, { "isoform_ac": "F1MCS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5/entry#F1MCS8-1", "sequence": { "sequence": "ILEMLEYNHYQVQTHLENPTKYHIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPSMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVSRIIKQEPALENCNQDLLQHHADLTCTTTLDLTDGTITFNNSLGAGTESSQAYSVPAKMGSKLEDILMDDTLSPVGITDPLLSSVSPGASKTSSRRSSMSMEETEHAC", "length": 419, "header": "tr|F1MCS8-1|F1MCS8_BOVIN Computationally mapped isoform of Melanocyte inducing transcription factor OS=Bos taurus OX=9913 GN=MITF PE=3 SV=2 CANONICAL=A0AAA9SVL5-1" }, "locus": { "chromosome": "22", "start_pos": 31650965, "end_pos": 31617850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008789.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008789.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008789.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008789.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3232118", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232118", "resource": "Reactome", "description": "SUMOylation of transcription factors" }, { "id": "R-BTA-9824594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9824594", "resource": "Reactome", "description": "Regulation of MITF-M-dependent genes involved in apoptosis" }, { "id": "R-BTA-9856649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856649", "resource": "Reactome", "description": "Transcriptional and post-translational regulation of MITF-M expression and activity" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription initiation", "id": "GO:2000144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000144", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" }, { "name": "melanocyte differentiation", "id": "GO:0030318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030318", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL5" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 305, "end_pos": 358, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 460, "end_pos": 462 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSG0-1", "uniprot_ac": "A0AAA9SSG0", "uniprot_id": "A0AAA9SSG0_BOVIN", "mass": { "chemical_mass": 93950.0, "monoisotopic_mass": 93950.0 }, "refseq": { "ac": "XP_024835264", "name": "P protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835264" }, "gene_names": [ { "name": "OCA2", "type": "recommended", "evidence": [ { "id": "A0AAA9SSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ] }, { "name": "OCA2", "type": "synonym", "evidence": [ { "id": "XP_024835264", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835264" } ] } ], "protein_names": [ { "name": "OCA2 melanosomal transmembrane protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0/entry#names_and_taxonomy" } ] }, { "name": "P protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024835264", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835264" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0", "locus": { "chromosome": "2", "start_pos": 424068, "end_pos": 704939, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009831", "url": "https://www.ensembl.org/id/ENSBTAG00000009831" } ] } } ], "crossref": [ { "id": "A0AAA9SSG0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009831", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009831", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524289", "url": "https://www.ncbi.nlm.nih.gov/gene/524289", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524289", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524289", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYM6", "url": "https://www.orthodb.org/?gene=A0A3Q1LYM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BA42", "url": "https://www.orthodb.org/?gene=E1BA42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43568", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43568", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43568:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43568:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5662702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5662702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024835264", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835264", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA42", "url": "https://www.uniprot.org/uniprotkb/E1BA42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA42-1", "url": "https://www.uniprot.org/uniprotkb/E1BA42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHLENKDGRLASGRLEMELHQTSAPTSAGLGGSGLVELNTSNRRPQQGVGRADSLSPYHNGAAGQSCWATVDQDFGSFLKERRSHPPFSQVFSSRSKEPCFTENTPLLRNFSQEKGSWCMPVCHPEFITGEESWEDSSTEWEGRSLLSRELAGSSESAFLEKGELLDSAHIRFRLAKLRCCVQWLKVTGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLESYSVNLSSHADSMLLQVGLAGALVAGSPSHLGREEHVMVEVTQANTPGSRRRRPQQVTHNWTIFLNPSGSEHVVVSRTFEVLSREPVSISIRASLQQTQIVPLLMTHQYLRASVEAQVTIAAVILAGVYVLIIFEIVHRTLAAMLGSLSALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKVYQLSRGRVWTMIFMLCLVAAVLSAFLDNVTTVLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVLIVSNQELRKMGLDFAGFTAHMFAGICFVLLFSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQHISPASREETAVRGMLLEKVLTLEHLLAQRLHSFHRQISQEDKNWETNIQELQRKHRISDKILLAKCLTVLVFVIFMFFLNSFIPGVHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEDQRLTAAIILVVWVSGITSSLIDNIPFTATMIPVLLNLSRDPEVSLPAPPLMYALALGSCLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCMVGMCYLLVAHIVMGWN", "length": 845, "header": "tr|A0AAA9SSG0-1|A0AAA9SSG0_BOVIN Isoform 1 of OCA2 melanosomal transmembrane protein OS=Bos taurus OX=9913 GN=OCA2 PE=4 SV=1 CANONICAL=A0AAA9SSG0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0/entry#A0A3Q1LYM6-1", "sequence": { "sequence": "MHLENKDGRLASGRLEMELHQTSAPTSAGLGGSGLVELNTSNRRPQQGVGRADSLSPYHNGAAGQSCWATVDQDFGSFLKERRSHPPFSQVFSSRSKEPCFTENTPLLRNFSQEKGSWCMPVCHPEFITGEESWEDSSTEWEGRSLLSRELAGSSESAFLEKGELLDSAHIRFRLAKLRCCVQWLKVTGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLESYSVNLSSHADSMLLQVGLAGALVAGSPSHLGREEHVMVEVTQANTPGSRRRRPQQVTHNWTIFLNPSGSEHVVVSRTFEVLSREPVSISIRASLQQTQIVPLLMTHQYLRASVEAQVTIAAVILAGVYVLIIFEIVHRTLAAMLGSLSALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKVYQLSRGRVWTMIFMLCLVAAVLSAFLDNVTTVLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVLIVSNQELRKMGLDFAGFTAHMFAGICFVLLFSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQHISPASREETAVRGMLLEKVLTLEHLLAQRLHSFHRQISQEDKNWETNIQELQRKHRISDKILLAKCLTVLVFVIFMFFLNSFIPGVHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEMVPEDQRLTAAIILVVWVSGITSSLIDNIPFTATMIPVLLNLSRDPEVSLPAPPLMYALALGSCLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCMVGMCYLLVAHIVMGWN", "length": 825, "header": "tr|A0A3Q1LYM6-1|A0AAA9SSG0_BOVIN Computationally mapped isoform of OCA2 melanosomal transmembrane protein OS=Bos taurus OX=9913 GN=OCA2 PE=4 SV=2 CANONICAL=A0AAA9SSG0-1" }, "locus": { "chromosome": "2", "start_pos": 671848, "end_pos": 425072, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072622.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072622.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062700.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062700.2" } ] } }, { "isoform_ac": "A0AAA9RUJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0/entry#A0AAA9RUJ2-1", "sequence": { "sequence": "MHLENKDGRLASGRLEMELHQTSAPTSAGLGGSGLVELNTSNRRPQQGVGRADSLSPYHNGAAGQSCWATVDQDFGSFLKERRSHPPFSQVFSSRSKEPCFTENTPLLRNFSQEKGSWCMPVCHPEFITGEESWEDSSTEWEGRSLLSRELAGSSESAFLEKGELLDSAHIRFRLAKLRCCVQWLKVTGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLESYSVNLSSHADSMLLQVGLAGALVAGSPSHLGREEHVMVEVTQANTPGSRRRRPQQVTHNWTIFLNPSGSEHVVVSRTFEVLSREPVSISIRASLQQTQIVPLLMTHQYLRASVEAQVTIAAVILAGVYVLIIFEIVHRTLAAMLGSLSALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKVYQLSRGRVWTMIFMLCLVAAVLSAFLDNVTTVLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVLIVSNQELRKMGLDFAGFTAHMFAGICFVLLFSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQHISPASREETAVRGMLLEKVLTLEHLLAQRLHSFHRQISQEDKNWETNIQELQRKHRISDKILLAKCLTVLVFVIFMFFLNSFIPGVHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEIPVLLNLSRDPEVSLPAPPLMYALALGSCLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCMVGMCYLLVAHIVMGWN", "length": 790, "header": "tr|A0AAA9RUJ2-1|A0AAA9SSG0_BOVIN Computationally mapped isoform of OCA2 melanosomal transmembrane protein OS=Bos taurus OX=9913 GN=OCA2 PE=4 SV=1 CANONICAL=A0AAA9SSG0-1" }, "locus": { "chromosome": "2", "start_pos": 671848, "end_pos": 425072, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127473.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127473.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076877.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076877.1" } ] } }, { "isoform_ac": "A0AAA9SSG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0/entry#A0AAA9SSG0-1", "sequence": { "sequence": "MHLENKDGRLASGRLEMELHQTSAPTSAGLGGSGLVELNTSNRRPQQGVGRADSLSPYHNGAAGQSCWATVDQDFGSFLKERRSHPPFSQVFSSRSKEPCFTENTPLLRNFSQEKGSWCMPVCHPEFITGEESWEDSSTEWEGRSLLSRELAGSSESAFLEKGELLDSAHIRFRLAKLRCCVQWLKVTGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLESYSVNLSSHADSMLLQVGLAGALVAGSPSHLGREEHVMVEVTQANTPGSRRRRPQQVTHNWTIFLNPSGSEHVVVSRTFEVLSREPVSISIRASLQQTQIVPLLMTHQYLRASVEAQVTIAAVILAGVYVLIIFEIVHRTLAAMLGSLSALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKVYQLSRGRVWTMIFMLCLVAAVLSAFLDNVTTVLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVLIVSNQELRKMGLDFAGFTAHMFAGICFVLLFSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQHISPASREETAVRGMLLEKVLTLEHLLAQRLHSFHRQISQEDKNWETNIQELQRKHRISDKILLAKCLTVLVFVIFMFFLNSFIPGVHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEDQRLTAAIILVVWVSGITSSLIDNIPFTATMIPVLLNLSRDPEVSLPAPPLMYALALGSCLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCMVGMCYLLVAHIVMGWN", "length": 845, "header": "tr|A0AAA9SSG0-1|A0AAA9SSG0_BOVIN Isoform 1 of OCA2 melanosomal transmembrane protein OS=Bos taurus OX=9913 GN=OCA2 PE=4 SV=1 CANONICAL=A0AAA9SSG0-1" }, "locus": { "chromosome": "2", "start_pos": 671848, "end_pos": 425072, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087053.1" } ] } }, { "isoform_ac": "A0AAA9TXD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0/entry#A0AAA9TXD2-1", "sequence": { "sequence": "MHLENKDGRLASGRLEMELHQTSAPTSAGLGGSGLVELNTSNRRPQQGVGRADSLSPYHNGAAGQSCWATVDQDFGSFLKERRSHPPFSQVFSSRSKEPCFTENTPLLRNFSQEKGSWCMPVCHPEFITGEESWEDSSTEWEGRSLLSRELAGSSESAFLEKGELLDSAHIRFRLAKLRCCVQWLKVTGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLESYSVNLSSHADSMLLQVGLAGALVAGSPSHLGREEHVMVEVTQANTPGSRRRRPQQVTHNWTIFLNPSGSEHVVVSRTFEVLSREPVSISIRASLQQTQIVPLLMTHQYLRASVEAQVTIAAVILAGVYVLIIFEIVHRTLAAMLGSLSALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKVYQLSRGRVWTMIFMLCLVAAVLSAFLDNVTTVLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVLIVSNQELRKMGLDFAGFTAHMFAGICFVLLFSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQHISPASREETAVRGMLLEKVLTLEHLLAQRLHSFHRQISQEDKNWETNIQELQRKALAHLHLIEYVGEQTALLIKMVPEDQRLTAAIILVVWVSGITSSLIDNIPFTATMIPVLLNLSRDPEVSLPAPPLMYALALGSCLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCMVGMCYLLVAHIVMGWN", "length": 766, "header": "tr|A0AAA9TXD2-1|A0AAA9TXD2_BOVIN Computationally mapped isoform of OCA2 melanosomal transmembrane protein OS=Bos taurus OX=9913 GN=OCA2 PE=4 SV=1 CANONICAL=A0AAA9SSG0-1" }, "locus": { "chromosome": "2", "start_pos": 671848, "end_pos": 425072, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115649.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115649.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101306.1" } ] } }, { "isoform_ac": "E1BA42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0/entry#E1BA42-1", "sequence": { "sequence": "MHLENKDGRLASGRLEMELHQTSAPTSAGLGGSGLVELNTSNRRPQQGVGRADSLSPYHNGAAGQSCWATVDQDFGSFLKERRSHPPFSQVFSSRSKEPCFTENTPLLRNFSQEKGSWCMPVCHPEFITGEESWEDSSTEWEGRSLLSRELAGSSESAFLEKGELLDSAHIRFRLAKLRCCVQWLKVTGLFVFVVLCSILFSLYPDQGKLWQLLAVSPLESYSVNLSSHADSMLLQVGLAGALVAGSPSHLGREEHVMVEVTQANTPGSRRRRPQQVTHNWTIFLNPSGSEHVVVSRTFEVLSREPVSISIRASLQQTQIVPLLMTHQYLRASVEAQVTIAAVILAGVYVLIIFEIVHRTLAAMLGSLSALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKVYQLSRGRVWTMIFMLCLVAAVLSAFLDNVTTVLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVLIVSNQELRKMGLDFAGFTAHMFAGICFVLLFSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQHISPASREETAVRGMLLEKVLTLEHLLAQRLHSFHRQISQEDKNWETNIQELQRKHRISDKILLAKCLTVLVFVIFMFFLNSFIPGVHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEDQRLTAAIILVVWVSGITSSLIDNIPFTATMCPPAFWYKG", "length": 764, "header": "tr|E1BA42-1|E1BA42_BOVIN Computationally mapped isoform of OCA2 melanosomal transmembrane protein OS=Bos taurus OX=9913 GN=OCA2 PE=4 SV=4 CANONICAL=A0AAA9SSG0-1" }, "locus": { "chromosome": "2", "start_pos": 671848, "end_pos": 443471, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012974.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012974.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012974.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012974.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524289", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524289", "resource": "KEGG Pathway" }, { "id": "R-BTA-5662702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5662702", "resource": "Reactome", "description": "Melanin biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ], "pmid": "" }, { "name": "melanosome membrane", "id": "GO:0033162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033162", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ], "pmid": "" }, { "name": "melanin biosynthetic process", "id": "GO:0042438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042438", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ], "pmid": "" }, { "name": "melanocyte differentiation", "id": "GO:0030318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030318", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 788, "end_pos": 790, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG0" }, { "id": "PF03600", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03600" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Citrate transporter-like", "eco_id": "ECO_0000259", "start_pos": 349, "end_pos": 782, "start_aa": "Tyr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 761, "end_pos": 763 }, { "start_pos": 788, "end_pos": 790 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS56-1", "uniprot_ac": "A0AAA9SS56", "uniprot_id": "A0AAA9SS56_BOVIN", "mass": { "chemical_mass": 204306.0, "monoisotopic_mass": 204306.0 }, "refseq": { "ac": "XP_005217049", "name": "kinesin-like protein KIF1B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217049" }, "gene_names": [ { "name": "KIF1B", "type": "recommended", "evidence": [ { "id": "A0AAA9SS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ] }, { "name": "KIF1B", "type": "synonym", "evidence": [ { "id": "XP_005217049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217049" } ] } ], "protein_names": [ { "name": "plus-end-directed kinesin ATPase", "type": "recommended", "evidence": [ { "id": "A0AAA9SS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#names_and_taxonomy" } ] }, { "name": "5.6.1.3", "type": "synonym", "evidence": [ { "id": "A0AAA9SS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#names_and_taxonomy" } ] }, { "name": "kinesin-like protein KIF1B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217049" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIF1B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56", "locus": { "chromosome": "16", "start_pos": 43194234, "end_pos": 43342514, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054239", "url": "https://www.ensembl.org/id/ENSBTAG00000054239" } ] } } ], "crossref": [ { "id": "ENSBTAG00000048747", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048747", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000054239", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054239", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01233", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01233", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22727", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22727", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100337161", "url": "https://www.ncbi.nlm.nih.gov/gene/100337161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRB7", "url": "https://www.orthodb.org/?gene=A0A3Q1LRB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47117:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47117:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00498", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00498", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12473", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12473", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16183", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16183", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217049", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217049", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRB7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1I7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1I7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1I7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQEEMEDFDEEAFVDDTGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQKTPEANSRASSPCPEFEQFQIVPPVETPYLARAGKNEFLNLVPDIEEIRPGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1816, "header": "tr|A0AAA9SS56-1|A0AAA9SS56_BOVIN Isoform 1 of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=1 CANONICAL=A0AAA9SS56-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0A3Q1LRB7-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDADSDSGDDSDKRSCEESWKLITSLREKLPPSKLQTIVKKCGLPSSGKKREPIKMYQIPQRRRLSKDSKWVTISDLKIQAVKEICYEVALNDFRHSRQEIEALAIVKMKELCAMYGKKDPNERDSWRAVARDVWDTVGVGDEKIEDVMASSKGGTDVDDLKVHIDKLEDILQEVKKQNNMKDEEIKVLRNKMLKMEKVLPLIGSPEQKTQGNQKSKEPSGAGASSKPENDVSKGDSGDLGKEERVSQLMNGDPAFRRGRLRWMRQEQIRFKNLQQQEITKQLRRQNVPHRFIPPENRKPRFPFKSNPKHRNSWSPGTHIIITEDEVIELRIPKEEDGRKGNKPENQEKGTRAASKDPQLPWGPQGTRSQDHIQVSKQHINNQQQPPQLRWRSNSLNNGQPKSTRCQASASPEVLASHSGHPTADLQTFQAKRHMHQHRQAYCSYNTGAQLEGSAATSCQKQTDRPNHCSQFVTPPRMRRQFSAPNLKTGRETTV", "length": 1153, "header": "tr|A0A3Q1LRB7-1|A0A3Q1LRB7_BOVIN Computationally mapped isoform of Kinesin family member 1B OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=1 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43256964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083891.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083891.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059670.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059670.1" } ] } }, { "isoform_ac": "A0A3Q1M1I7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0A3Q1M1I7-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKILTPRPCDLFLDPSGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQEEMEDFDEEAFVDDTGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQKTPEANSRASSPCPEFEQFQIVPPVETPYLARAGKNEFLNLVPDIEEIRPGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1791, "header": "tr|A0A3Q1M1I7-1|A0AAA9SS56_BOVIN Computationally mapped isoform of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=2 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43195238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078974.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078974.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063814.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063814.2" } ] } }, { "isoform_ac": "A0A3Q1MPX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0A3Q1MPX6-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQNSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1637, "header": "tr|A0A3Q1MPX6-1|A0A3Q1MPX6_BOVIN Computationally mapped isoform of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=2 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43195238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086287.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086287.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073585.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073585.2" } ] } }, { "isoform_ac": "A0AAA9SN02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0AAA9SN02-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKISPQVPATLNYNSLEAISAVQTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQEEMEDFDEEAFVDDTGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQKTPEANSRASSPCPEFEQFQIVPPVETPYLARAGKNEFLNLVPDIEEIRPGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1791, "header": "tr|A0AAA9SN02-1|A0AAA9SS56_BOVIN Computationally mapped isoform of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=1 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43195238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084176.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084176.1" } ] } }, { "isoform_ac": "A0AAA9SS56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0AAA9SS56-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQEEMEDFDEEAFVDDTGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQKTPEANSRASSPCPEFEQFQIVPPVETPYLARAGKNEFLNLVPDIEEIRPGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1816, "header": "tr|A0AAA9SS56-1|A0AAA9SS56_BOVIN Isoform 1 of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=1 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43195238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119568.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119568.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089219.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089219.1" } ] } }, { "isoform_ac": "A0AAA9TP34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0AAA9TP34-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQKTPEANSRASSPCPEFEQFQIVPPVETPYLARAGKNEFLNLVPDIEEIRPGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1670, "header": "tr|A0AAA9TP34-1|A0AAA9TP34_BOVIN Computationally mapped isoform of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=1 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43195238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108676.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108676.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099002.1" } ] } }, { "isoform_ac": "A0AAA9TZH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56/entry#A0AAA9TZH9-1", "sequence": { "sequence": "MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGHLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDTETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDTSMGSLTSSPSSCSLNSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNNSGDVIVTLEPCERSETYVNGKRVTQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEIEKTQEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQEEMEDFDEEAFVDDTGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDISSVALTRSGLSLEELRIVEGQGQSSEVITPPEEVNRMNDLDLKSSTLLDGKMMMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELHSPPQPSRRFFPPPMPLSKPDHERKIELIRFLVSDYVNVHVLDTFSEHANVLASSAIATFQDGADPSPPFLFLPVPSCQPERVPKRDVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKAEVDEAAVDAILSLNIISAKYLKSSHNCSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRDRLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSADIESLVDREKELATKCLQLLTHTFNREFSQVHGSISDCKLADLSPVGRDPSVSSLSSSTLTPSSTCPSLVDARSNSLDQKTPEANSRASSPCPEFEQFQIVPPVETPYLARAGKNEFLNLVPDIEEIRPGSVVSKKGYLHFKEPLSSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDVNDWLYAFNPLLAGTIRSKLSRRCPSQAKY", "length": 1837, "header": "tr|A0AAA9TZH9-1|A0AAA9TZH9_BOVIN Computationally mapped isoform of plus-end-directed kinesin ATPase OS=Bos taurus OX=9913 GN=KIF1B PE=3 SV=1 CANONICAL=A0AAA9SS56-1" }, "locus": { "chromosome": "16", "start_pos": 43328202, "end_pos": 43195238, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131634.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131634.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102129.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "plus-end-directed microtubule motor activity", "id": "GO:0008574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008574", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "transport vesicle membrane", "id": "GO:0030658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030658", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "transport along microtubule", "id": "GO:0010970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010970", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" }, { "name": "retrograde neuronal dense core vesicle transport", "id": "GO:1990049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990049", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1042, "end_pos": 1044, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1349, "end_pos": 1351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1746, "end_pos": 1748, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 488, "end_pos": 490, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" }, { "id": "PS50006", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50006" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FHA", "eco_id": "ECO_0000259", "start_pos": 556, "end_pos": 612, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 354, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS56" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 1701, "end_pos": 1799, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.6.1.3", "ec_name": "ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate a kinesin associated with a microtubule at position (n+1, toward the plus end).", "evidence": [ { "id": "5.6.1.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.6.1.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1042, "end_pos": 1044 }, { "start_pos": 1349, "end_pos": 1351 }, { "start_pos": 1746, "end_pos": 1748 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 488, "end_pos": 490 }, { "start_pos": 588, "end_pos": 590 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWE1-1", "uniprot_ac": "A0AAA9SWE1", "uniprot_id": "A0AAA9SWE1_BOVIN", "mass": { "chemical_mass": 64177.0, "monoisotopic_mass": 64177.0 }, "refseq": {}, "gene_names": [ { "name": "BBS4", "type": "recommended", "evidence": [ { "id": "A0AAA9SWE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ] } ], "protein_names": [ { "name": "BBSome complex member BBS4", "type": "recommended", "evidence": [ { "id": "A0AAA9SWE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BBS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1", "locus": { "chromosome": "10", "start_pos": 19532111, "end_pos": 19486049, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007614", "url": "https://www.ensembl.org/id/ENSBTAG00000007614" } ] } } ], "crossref": [ { "id": "A0AAA9SWE1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWE1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007614", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007614", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532120", "url": "https://www.ncbi.nlm.nih.gov/gene/532120", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLA1", "url": "https://www.orthodb.org/?gene=A0A3Q1MLA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44186", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44186", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44186:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44186:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14559", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14559", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MLA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLA1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRD5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YRD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YRD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPQ8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKESKKIMSDSVRPSELQPARLLCPWDSPAKNTGVGGHGLLQGLFLTQIEPASLTYTLHQQRTQLPVSAESQKPVLKKAPEFPILEKQNWLIHLYYIQKDYEACKAVIKEQLQETHGLCEYAIYVQALIFRLEGNIQESLRLFQMCAFLSPQCADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEICHNLGVCYIYLKQFDKAQDQLHNALHLNRHDLTYIMLGKIFLLKGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNTLTYDPTNYKAILAAGSMMQTHGDFDVALTKYKVVACAVIESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPLDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDSENAKRAYEEAVRLDKCNPLVNLNYAVLLYNQGEKRDALAQYQEMEKKVNLLKYSSSLEFDPEMVEVAQKLGAALQVGEALVWTKPVKDPKSKHQTASTSKAAGFQQPLGSNQALGQAMSSAATCRKLSSGAGGTSQLTKPPSLPLEPEPTVEAQPTEASAQTREK", "length": 573, "header": "tr|A0AAA9SWE1-1|A0AAA9SWE1_BOVIN Isoform 1 of BBSome complex member BBS4 OS=Bos taurus OX=9913 GN=BBS4 PE=3 SV=1 CANONICAL=A0AAA9SWE1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1/entry#A0A3Q1MLA1-1", "sequence": { "sequence": "MIWSTRNSAYTFTAPEFPILEKQNWLIHLYYIQKDYEACKAVIKEQLQETHGLCEYAIYVQALIFRLEGNIQESLRLFQMCAFLSPQCADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEICHNLGVCYIYLKQFDKAQDQLHNALHLNRHDLTYIMLGKIFLLKGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNTLTYDPTNYKAILAAGSMMQTHGDFDVALTKYKVVACAVIESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPLDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDSENAKRAYEEAVRLDKCNPLVNLNYAVLLYNQGEKRDALAQYQEMEKKVNLLKYSSSLEFDPEMVEVAQKLGAALQVGEALVWTKPVKDPKSKHQTASTSKAAGFQQPLGSNQALGQAMSSAATCRKLSSGAGGTSQLTKPPSLPLEPEPTVEAQPTEASAQTREK", "length": 507, "header": "tr|A0A3Q1MLA1-1|A0AAA9SWE1_BOVIN Computationally mapped isoform of BBSome complex member BBS4 OS=Bos taurus OX=9913 GN=BBS4 PE=3 SV=1 CANONICAL=A0AAA9SWE1-1" }, "locus": { "chromosome": "10", "start_pos": 19531420, "end_pos": 19506890, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069146.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069146.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070054.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070054.1" } ] } }, { "isoform_ac": "A0AAA9SWE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1/entry#A0AAA9SWE1-1", "sequence": { "sequence": "MKKESKKIMSDSVRPSELQPARLLCPWDSPAKNTGVGGHGLLQGLFLTQIEPASLTYTLHQQRTQLPVSAESQKPVLKKAPEFPILEKQNWLIHLYYIQKDYEACKAVIKEQLQETHGLCEYAIYVQALIFRLEGNIQESLRLFQMCAFLSPQCADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEICHNLGVCYIYLKQFDKAQDQLHNALHLNRHDLTYIMLGKIFLLKGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNTLTYDPTNYKAILAAGSMMQTHGDFDVALTKYKVVACAVIESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPLDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDSENAKRAYEEAVRLDKCNPLVNLNYAVLLYNQGEKRDALAQYQEMEKKVNLLKYSSSLEFDPEMVEVAQKLGAALQVGEALVWTKPVKDPKSKHQTASTSKAAGFQQPLGSNQALGQAMSSAATCRKLSSGAGGTSQLTKPPSLPLEPEPTVEAQPTEASAQTREK", "length": 573, "header": "tr|A0AAA9SWE1-1|A0AAA9SWE1_BOVIN Isoform 1 of BBSome complex member BBS4 OS=Bos taurus OX=9913 GN=BBS4 PE=3 SV=1 CANONICAL=A0AAA9SWE1-1" }, "locus": { "chromosome": "10", "start_pos": 19531420, "end_pos": 19489042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101286.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101286.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089643.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089643.1" } ] } }, { "isoform_ac": "A0AAA9TMX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1/entry#A0AAA9TMX9-1", "sequence": { "sequence": "MSDSVRPSELQPARLLCPWDSPAKNTGVGGHGLLQGLFLTQIEPASLTYTLHQQRTQLPVSAESQKPVLKKAPEFPILEKQNWLIHLYYIQKDYEACKAVIKEQLQETHGLCEYAIYVQALIFRLEGNIQESLRLFQMCAFLSPQCADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEICHNLGVCYIYLKQFDKAQDQLHNALHLNRHDLTYIMLGKIFLLKGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNTLTYDPTNYKAILAAGSMMQTHGDFDVALTKYKVVACAVIESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPLDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDSENAKRAYEEAVRLDKCNPLVNLNYAVLLYNQGEKRDALAQYQEMEKKVNLLKYSSSLEFDPEMVEVAQKLGAALQVGEALVWTKPVKDPKSKHQTASTSKAAGFQQPLGSNQALGQAMSSAATCRKLSSGAGGTSQLTKPPSLPLEPEPTVEAQPTEASAQTREK", "length": 565, "header": "tr|A0AAA9TMX9-1|A0AAA9TMX9_BOVIN Computationally mapped isoform of BBSome complex member BBS4 OS=Bos taurus OX=9913 GN=BBS4 PE=3 SV=1 CANONICAL=A0AAA9SWE1-1" }, "locus": { "chromosome": "10", "start_pos": 19531420, "end_pos": 19493326, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095233.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095233.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099716.1" } ] } }, { "isoform_ac": "A0AAF6YRD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1/entry#A0AAF6YRD5-1", "sequence": { "sequence": "MSDSVRPSELQPARLLCPWDSPAKNTGRTQLPVSAESQKPVLKKAPEFPILEKQNWLIHLYYIQKDYEACKAVIKEQLQETHGLCEYAIYVQALIFRLEGNIQESLRLFQMCAFLSPQCADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEICHNLGVCYIYLKQFDKAQDQLHNALHLNRHDLTYIMLGKIFLLKGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNTLTYDPTNYKAILAAGSMMQTHGDFDVALTKYKVVACAVIESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPLDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDSENAKRAYEEAVRLDKCNPLVNLNYAVLLYNQGEKRDALAQYQEMEKKVNLLKYSSSLEFDPEMVEVAQKLGAALQVGEALVWTKPVKDPKSKHQTASTSKAAGFQQPLGSNQALGQAMSSAATCRKLSSGAGGTSQLTKPPSLPLEPEPTVEAQPTEASAQTREK", "length": 538, "header": "tr|A0AAF6YRD5-1|A0AAF6YRD5_BOVIN Computationally mapped isoform of BBSome complex member BBS4 OS=Bos taurus OX=9913 GN=BBS4 PE=3 SV=1 CANONICAL=A0AAA9SWE1-1" }, "locus": { "chromosome": "10", "start_pos": 19531420, "end_pos": 19493326, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010013.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010013.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010013.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010013.4" } ] } }, { "isoform_ac": "A0ABI0NPQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1/entry#A0ABI0NPQ8-1", "sequence": { "sequence": "MAEEKLSAAVIKEQLQETHGLCEYAIYVQALIFRLEGNIQESLRLFQMCAFLSPQCADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEICHNLGVCYIYLKQFDKAQDQLHNALHLNRHDLTYIMLGKIFLLKGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNTLTYDPTNYKAILAAGSMMQTHGDFDVALTKYKVVACAVIESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPLDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDSENAKRAYEEAVRLDKCNPLVNLNYAVLLYNQGEKRDALAQYQEMEKKVNLLKYSSSLEFDPEMVEVAQKLGAALQVGEALVWTKPVKDPKSKHQTASTSKAAGFQQPLGSNQALGQAMSSAATCRKLSSGAGGTSQLTKPPSLPLEPEPTVEAQPTEASAQTREK", "length": 475, "header": "tr|A0ABI0NPQ8-1|A0ABI0NPQ8_BOVIN Computationally mapped isoform of BBSome complex member BBS4 OS=Bos taurus OX=9913 GN=BBS4 PE=3 SV=1 CANONICAL=A0AAA9SWE1-1" }, "locus": { "chromosome": "10", "start_pos": 19531420, "end_pos": 19486154, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141926.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141926.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107727.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "sensory perception", "id": "GO:0007600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007600", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "negative regulation of appetite by leptin-mediated signaling pathway", "id": "GO:0038108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "regulation of cilium beat frequency involved in ciliary motility", "id": "GO:0060296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "BBSome", "id": "GO:0034464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUX3-1", "uniprot_ac": "A0AAA9SUX3", "uniprot_id": "A0AAA9SUX3_BOVIN", "mass": { "chemical_mass": 111995.0, "monoisotopic_mass": 111995.0 }, "refseq": { "ac": "XP_059744246", "name": "multiple C2 and transmembrane domain-containing protein 1 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744246" }, "gene_names": [ { "name": "MCTP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ] }, { "name": "MCTP1", "type": "synonym", "evidence": [ { "id": "XP_059744246", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744246" } ] } ], "protein_names": [ { "name": "Multiple C2 and transmembrane domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3/entry#names_and_taxonomy" } ] }, { "name": "multiple C2 and transmembrane domain-containing protein 1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_059744246", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744246" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCTP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3", "locus": { "chromosome": "7", "start_pos": 94027847, "end_pos": 94590746, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054976", "url": "https://www.ensembl.org/id/ENSBTAG00000054976" } ] } } ], "crossref": [ { "id": "A0AAA9SUX3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054976", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054976", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08377", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08377", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533635", "url": "https://www.ncbi.nlm.nih.gov/gene/533635", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45911:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45911:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059744246", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744246", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N846", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N846", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N846-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N846-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPRAAAAGSPEPAAAAAASSFQARLWKNLQLGVGKSKGGGGARAGGPERRTADTPSPSPPPPGGRRDAPAALGGAGSRWSGFKKRKQVLDRVFSSSQPNLCCSSPEPLEPGGTGRAEPGSTLRRRIRGHLLPVGKGPGAATAAAAASATPPGGRSPDSAPSSSSASSSLSSSPQPPPRGDRARDEGARRRGTAAHLCHQKSSSLPGTACLEQLLEPPPPLPPRAEPAPSPAESRTPEKGPERGSSGKINTAGTSNADVPLAEPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGRKEVFRSKIIHKNLNPVWEEKACLLVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGEHVTMLMRKSWKRSSKELSENEVLGSYFSVKSFFWRTCGRPALPVLGFCRAELQSTHYQNAQFQTQSLRLSDVHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIIDITAWDKDAGKRDDFIGRCQIDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDRKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRTKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCISVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCAFTVILYFIPLRYIVLVWGINKFTKKLRNPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPCKRKKNNLG", "length": 1003, "header": "tr|A0AAA9SUX3-1|A0AAA9SUX3_BOVIN Isoform 1 of Multiple C2 and transmembrane domain-containing protein 1 OS=Bos taurus OX=9913 GN=MCTP1 PE=3 SV=1 CANONICAL=A0AAA9SUX3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N846-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3/entry#A0A3Q1N846-1", "sequence": { "sequence": "MLYSCKLKGACNLPVICNKKINTAGTSNADVPLAEPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGRKEVFRSKIIHKNLNPVWEEKACLLVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGEHVTMLMRKSWKRSSKELSENEVLGSYFSVKSFFWRTCGRPALPVLGFCRAELQSTHYQNAQFQTQSLRLSDVHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIIDITAWDKDAGKRDDFIGRCQIDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDRKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRTKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCISVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCAFTVILYFIPLRYIVLVWGINKFTKKLRNPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPCKRKKNNLG", "length": 775, "header": "tr|A0A3Q1N846-1|A0AAA9SUX3_BOVIN Computationally mapped isoform of Multiple C2 and transmembrane domain-containing protein 1 OS=Bos taurus OX=9913 GN=MCTP1 PE=3 SV=2 CANONICAL=A0AAA9SUX3-1" }, "locus": { "chromosome": "7", "start_pos": 94398480, "end_pos": 94029774, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086779.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086779.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067097.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067097.2" } ] } }, { "isoform_ac": "A0AAA9SUX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3/entry#A0AAA9SUX3-1", "sequence": { "sequence": "MEPRAAAAGSPEPAAAAAASSFQARLWKNLQLGVGKSKGGGGARAGGPERRTADTPSPSPPPPGGRRDAPAALGGAGSRWSGFKKRKQVLDRVFSSSQPNLCCSSPEPLEPGGTGRAEPGSTLRRRIRGHLLPVGKGPGAATAAAAASATPPGGRSPDSAPSSSSASSSLSSSPQPPPRGDRARDEGARRRGTAAHLCHQKSSSLPGTACLEQLLEPPPPLPPRAEPAPSPAESRTPEKGPERGSSGKINTAGTSNADVPLAEPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGRKEVFRSKIIHKNLNPVWEEKACLLVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGEHVTMLMRKSWKRSSKELSENEVLGSYFSVKSFFWRTCGRPALPVLGFCRAELQSTHYQNAQFQTQSLRLSDVHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIIDITAWDKDAGKRDDFIGRCQIDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDRKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRTKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCISVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCAFTVILYFIPLRYIVLVWGINKFTKKLRNPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPCKRKKNNLG", "length": 1003, "header": "tr|A0AAA9SUX3-1|A0AAA9SUX3_BOVIN Isoform 1 of Multiple C2 and transmembrane domain-containing protein 1 OS=Bos taurus OX=9913 GN=MCTP1 PE=3 SV=1 CANONICAL=A0AAA9SUX3-1" }, "locus": { "chromosome": "7", "start_pos": 94590746, "end_pos": 94029774, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115159.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115159.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087970.1" } ] } }, { "isoform_ac": "A0AAA9TQG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3/entry#A0AAA9TQG6-1", "sequence": { "sequence": "MLYSCKLKGACNLPVICNKKINTAGTSNADVPLAEPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGRKEVFRSKIIHKNLNPVWEEKACLLVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGEHVTMLMRKSWKRSSKFQTQSLRLSDVHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIIDITAWDKDAGKRDDFIGRCQIDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDRKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRTKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCISVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCAFTVILYFIPLRYIVLVWGINKFTKKLRNPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPCKRKKNNLG", "length": 689, "header": "tr|A0AAA9TQG6-1|A0AAA9TQG6_BOVIN Computationally mapped isoform of Multiple C2 and transmembrane domain-containing protein 1 OS=Bos taurus OX=9913 GN=MCTP1 PE=3 SV=1 CANONICAL=A0AAA9SUX3-1" }, "locus": { "chromosome": "7", "start_pos": 94398480, "end_pos": 94029774, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109361.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109361.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099538.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 150, "start_aa": "Thr", "end_pos": 150, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr150", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 737, "start_aa": "Thr", "end_pos": 737, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr737", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 914, "end_pos": 916, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUX3" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 245, "end_pos": 366, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 150, 737 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 914, "end_pos": 916 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWH1-1", "uniprot_ac": "A0AAA9SWH1", "uniprot_id": "A0AAA9SWH1_BOVIN", "mass": { "chemical_mass": 164556.0, "monoisotopic_mass": 164556.0 }, "refseq": {}, "gene_names": [ { "name": "IRAG2", "type": "recommended", "evidence": [ { "id": "A0AAA9SWH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" } ] } ], "protein_names": [ { "name": "Inositol 1,4,5-triphosphate receptor associated 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SWH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IRAG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1", "locus": { "chromosome": "5", "start_pos": 84886579, "end_pos": 84996328, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019711", "url": "https://www.ensembl.org/id/ENSBTAG00000019711" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019711", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019711", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15352:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15352:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14658", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14658", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N886", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N886", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N886-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N886-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4X8", "url": "https://www.uniprot.org/uniprotkb/F1N4X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4X8-1", "url": "https://www.uniprot.org/uniprotkb/F1N4X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAKKVAEKRHNPVESICRKLRAIQKREDISDPIRQIIKYQSSSFDSPQTNPKKDFEEVLKKMMAAHVPLLDTLFLSPEKDGTFTSQSQIVSPRTPSISHLSSPENATYSLILAGSENISRPRSQSSQNYTSLTPQIMKRELFANKDLTNYCSENDFSTLALDFDSTSDQSSTPQDSVVKKLSLNEEGWKQGTDDGKEDVTSSNTRTYEEELLRSIFNICDSKRRGLVRVTKIIDYLRQTTSQGSEDDDLEELWIMLDPEKRDVHVNLETFQATVKEWMMAHCRNKWERENSGSSSTMVDSAFEQDNIKSCEAIKMTTDKTDSSSWNFKGLGGDLPKGVLEVPDLITYIADMHFNKQKLEEENNKLKLALENLEEANRELSEDCTELRLQIKSAHQAIMRTNLLKEELEELKITMNASEEQKTMIVAQNKQLETENRALILKIRILQEENAKNIMDIYKLEEKIEDLSKTEKEHQMQLHMYENTLLNTDASLQKKDVSIEELKSTIIEYGSIIENLRGEKNKLAQELQHLQQEFMINGMQLNVSGEHKSVDSEGVKSLHCELILAQSAENNETEWQCNLISLSSLDMIMDEEMLLLLTELEQKGVEFTATLQNLHEDVSEVETLIDHFLLWVTNPEITVKEKWENKLTEFRYIMEEKLNLCILMLNDLRNHKESLDKEFAKLIDILKRFRLEYFYFRKEFLSRQKQLETITQLQEVTVKQEAIFRKQVQEASQWLEEAEKQVEDGDGAAHTAGEEAKPSLHKLEQAISDQRNLQTINTEIVNTCQTLGQRTRKPKTTIQPLRKKLIKGQLHGLLFQSCLDEEFPHCDPLSCTERIHQFLQEQLKQHCHKRYSDPEARIHPLPLTFRHTCWYTPLLDALHLDSFTAIPRLELTPFSCVANLIHASHERPRYEEIEDGALAVTERHRCPGPSAGPHPGTDLSGCIRMNNDLSMEENGVEYLCSESQPQSREYSTLPSPGHTSSTESTVTSSDSGSEILHMASGDLDCKPLCEKEEDKRSASAVTKIQGGSPAPENIELQGSVSGEKSMLIQEAKKDPETIDEHRKECAAGGAALSSLPVKSVNFRQSDNTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEIANCLKLLESLTSLCEDDSQAQEIIKKLEKSITFLSQCTTRVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDEDDCQTKKRSSSVNSKPSSLRRVTIASLPRNIGNAGMLAGMENNDRFSRRSSSWRILGSKQSEHRPSLHRFISTYSWADAEEEKCELKTKDDLEPPEEETVEKTRKPSLSEKKTNPSKWNVSSIYDTLASWATNLKTSIREANKVLWLSVAFIVLFAALMSFFTGRFFQKPVDAAPTQDGDPWMSLEHILWPFTRLRHNGPPPV", "length": 1441, "header": "tr|A0AAA9SWH1-1|A0AAA9SWH1_BOVIN Isoform 1 of Inositol 1,4,5-triphosphate receptor associated 2 OS=Bos taurus OX=9913 GN=IRAG2 PE=4 SV=1 CANONICAL=A0AAA9SWH1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N886-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1/entry#A0A3Q1N886-1", "sequence": { "sequence": "METQNFNNPRNLLCVTSTSTSPPPGGTSDLISIITTIQPLRKKLIKGQLHGLLFQSCLDEEFPHCDPLSCTERIHQFLQEQLQHCHKRYSDPEARIHPLPLTFRHTCWYTPLLDALHLDSFTAIPRLELTPFSCVANLIHASHERPRYEEIEDGALAVTERHRCPGPSAGPHPGTDLSGCIRMNNDLSMEENGVEYLCSESQPQSREYSTLPSPGHTSSTESTVTSSDSGSEILHMASGDLDCKPLCEKEEDKRSASAVTKIQGGSPAPENIELQGSVSGEKSMLIQEAKKDPETIDEHRKECAAGGAALSSLPVKSVNFRQSDNTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEIANCLKLLESLTSLCEDDSQAQEIIKKLEKSITFLSQCTTRVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDEDDCQTKKRSSSVNSKPSSLRRVTIASLPRNIGNAGMLAGMENNDRFSRRSSSWRILGSKQSEHRPSLHRFISTYSWADAEEEKCELKTKDDLEPPEEETVEKTRKPSLSEKKTNPSKWNVSSIYDTLASWATNLKTSIREANKVLWLSVAFIVLFAALMSFFTGRFFQKPVDAAPTQDGDPWMSLEHILWPFTRLRHNGPPPV", "length": 678, "header": "tr|A0A3Q1N886-1|A0AAA9SWH1_BOVIN Computationally mapped isoform of Inositol 1,4,5-triphosphate receptor associated 2 OS=Bos taurus OX=9913 GN=IRAG2 PE=4 SV=3 CANONICAL=A0AAA9SWH1-1" }, "locus": { "chromosome": "5", "start_pos": 84938189, "end_pos": 84887470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068397.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068397.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067181.3", "url": "https://www.ensembl.org/id/ENSBTAP00000067181.3" } ] } }, { "isoform_ac": "A0AAA9SWH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1/entry#A0AAA9SWH1-1", "sequence": { "sequence": "MASAKKVAEKRHNPVESICRKLRAIQKREDISDPIRQIIKYQSSSFDSPQTNPKKDFEEVLKKMMAAHVPLLDTLFLSPEKDGTFTSQSQIVSPRTPSISHLSSPENATYSLILAGSENISRPRSQSSQNYTSLTPQIMKRELFANKDLTNYCSENDFSTLALDFDSTSDQSSTPQDSVVKKLSLNEEGWKQGTDDGKEDVTSSNTRTYEEELLRSIFNICDSKRRGLVRVTKIIDYLRQTTSQGSEDDDLEELWIMLDPEKRDVHVNLETFQATVKEWMMAHCRNKWERENSGSSSTMVDSAFEQDNIKSCEAIKMTTDKTDSSSWNFKGLGGDLPKGVLEVPDLITYIADMHFNKQKLEEENNKLKLALENLEEANRELSEDCTELRLQIKSAHQAIMRTNLLKEELEELKITMNASEEQKTMIVAQNKQLETENRALILKIRILQEENAKNIMDIYKLEEKIEDLSKTEKEHQMQLHMYENTLLNTDASLQKKDVSIEELKSTIIEYGSIIENLRGEKNKLAQELQHLQQEFMINGMQLNVSGEHKSVDSEGVKSLHCELILAQSAENNETEWQCNLISLSSLDMIMDEEMLLLLTELEQKGVEFTATLQNLHEDVSEVETLIDHFLLWVTNPEITVKEKWENKLTEFRYIMEEKLNLCILMLNDLRNHKESLDKEFAKLIDILKRFRLEYFYFRKEFLSRQKQLETITQLQEVTVKQEAIFRKQVQEASQWLEEAEKQVEDGDGAAHTAGEEAKPSLHKLEQAISDQRNLQTINTEIVNTCQTLGQRTRKPKTTIQPLRKKLIKGQLHGLLFQSCLDEEFPHCDPLSCTERIHQFLQEQLKQHCHKRYSDPEARIHPLPLTFRHTCWYTPLLDALHLDSFTAIPRLELTPFSCVANLIHASHERPRYEEIEDGALAVTERHRCPGPSAGPHPGTDLSGCIRMNNDLSMEENGVEYLCSESQPQSREYSTLPSPGHTSSTESTVTSSDSGSEILHMASGDLDCKPLCEKEEDKRSASAVTKIQGGSPAPENIELQGSVSGEKSMLIQEAKKDPETIDEHRKECAAGGAALSSLPVKSVNFRQSDNTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEIANCLKLLESLTSLCEDDSQAQEIIKKLEKSITFLSQCTTRVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDEDDCQTKKRSSSVNSKPSSLRRVTIASLPRNIGNAGMLAGMENNDRFSRRSSSWRILGSKQSEHRPSLHRFISTYSWADAEEEKCELKTKDDLEPPEEETVEKTRKPSLSEKKTNPSKWNVSSIYDTLASWATNLKTSIREANKVLWLSVAFIVLFAALMSFFTGRFFQKPVDAAPTQDGDPWMSLEHILWPFTRLRHNGPPPV", "length": 1441, "header": "tr|A0AAA9SWH1-1|A0AAA9SWH1_BOVIN Isoform 1 of Inositol 1,4,5-triphosphate receptor associated 2 OS=Bos taurus OX=9913 GN=IRAG2 PE=4 SV=1 CANONICAL=A0AAA9SWH1-1" }, "locus": { "chromosome": "5", "start_pos": 84987944, "end_pos": 84887470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110424.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110424.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089670.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089670.1" } ] } }, { "isoform_ac": "F1N4X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1/entry#F1N4X8-1", "sequence": { "sequence": "MASAKKVAEKRHNPVESICRKLRAIQKREDISDPIRQIIKYQSSSFDSPQTNPKKDFEEVLKKMMAAHVPLLDTLFLSPEKDGTFTSQSQIVSPRTPSISHLSSPENATYSLILAGSENISRPRSQSSQNYTSLTPQIMKRELFANKDLTNYCSENDFSTLALDFDSTSDQSSTPQDSVVKKLSLNEEGWKQGTDDGKEDVTSSNTRTYEEELLRSIFNICDSKRRGLVRVTKIIDYLRQTTSQGSEDDDLEELWIMLDPEKRDVHVNLETFQATVKEWMMAHCRNKWERENSGSSSTMVDSAFEQDNIKSCEAIKMTTDKTDSSSWNFKGLGGDLPKGVLEVPDLITYIADMHFNKQKLEEENNKLKLALENLEEANRELSEDCTELRLQIKSAHQAIMRTNLLKEELEELKITMNASEEQKTMIVAQNKQLETENRALILKIRILQEEMQLHMYENTLLNTDASLQKKDVSIEELKSTIIEYGSIIENLRGEKNKLAQELQHLQQEFMINGMQLNVSGEHKSVDSEGVKSLHCELILAQSAENNETEWQCNLISLSSLDMIMDEEMLLLLTELEQKGVEFTATLQNLHEDVSEVETLIDHFLLWVTNPEITVKEKWENKLTEFRYIMEEKLNLCILMLNDLRNHKESLDKEFAKLIDILKRFRLEYFYFRKEFLSRQKQLETITQLQEVTVKQEAIFRKQVQEASQWLEEAEKQVEDGDGAAHTAGEEAKPSLHKLEQAISDQRNLQTINTEIVNTCQTLGQRTRKPKTTIQPLRKKLIKGQLHGLLFQSCLDEEFPHCDPLSCTERIHQFLQEQLKQHCHKRYSDPEARIHPLPLTFRHTCWYTPLLDALHLDSFTAIPRLELTPFSCVANLIHASHERPRYEEIEDGALAVTERHRCPGPSAGPHPGTDLSGCIRMNNDLSMEENGVEYLCSESQPQSREYSTLPSPGHTSSTESTVTSSDSGSEILHMASGDLDCKPLCEKEEDKRSASAVTKIQGGSPAPENIELQGSVSGEKSMLIQEAKKDPETIDEHRKECAAGGAALSSLPVKSVNFRQSDNTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEIANCLKLLESLTSLCEDDSQAQEIIKKLEKSITFLSQCTTRVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDEDDCQTKKRSSSVNSKPSSLRRVTIASLPRNIGNAGMLAGMENNDRFSRRSSSWRILGSKQSEHRPSLHRFISTYSWADAEEEKCELKTKDDLEPPEEETVEKTRKPSLSEKKTNPSKWNVSSIYDTLASWATNLKTSIREANKVLWLSVAFIVLFAALMSFFTGRFFQKPVDAAPTQDGDPWMSLEHILWPFTRLRHNGPPPV", "length": 1415, "header": "tr|F1N4X8-1|F1N4X8_BOVIN Computationally mapped isoform of Inositol 1,4,5-triphosphate receptor associated 2 OS=Bos taurus OX=9913 GN=IRAG2 PE=4 SV=3 CANONICAL=A0AAA9SWH1-1" }, "locus": { "chromosome": "5", "start_pos": 84987944, "end_pos": 84887470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026270.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026270.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026270.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026270.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1088, "end_pos": 1090, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1357, "end_pos": 1359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" }, { "id": "PF14662", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14662" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KASH5-like coiled-coil", "eco_id": "ECO_0000259", "start_pos": 344, "end_pos": 530, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SWH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH1" }, { "id": "PF14658", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14658" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein KASH5 EF-hand-like", "eco_id": "ECO_0000259", "start_pos": 216, "end_pos": 279, "start_aa": "Ser", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 1088, "end_pos": 1090 }, { "start_pos": 119, "end_pos": 121 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 1357, "end_pos": 1359 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 543, "end_pos": 545 }, { "start_pos": 572, "end_pos": 574 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS91-1", "uniprot_ac": "A0AAA9SS91", "uniprot_id": "A0AAA9SS91_BOVIN", "mass": { "chemical_mass": 148982.0, "monoisotopic_mass": 148982.0 }, "refseq": {}, "gene_names": [ { "name": "TTC21A", "type": "recommended", "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 21A", "type": "synonym", "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC21A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91", "locus": { "chromosome": "22", "start_pos": 12475810, "end_pos": 12441150, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010477", "url": "https://www.ensembl.org/id/ENSBTAG00000010477" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010477", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010477", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540604", "url": "https://www.ncbi.nlm.nih.gov/gene/540604", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NAK0", "url": "https://www.orthodb.org/?gene=A0A3Q1NAK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N307", "url": "https://www.orthodb.org/?gene=F1N307", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14699", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14699", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14699:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14699:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25058", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25060", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25060", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25064", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25064", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25068", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25068", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NAK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N307", "url": "https://www.uniprot.org/uniprotkb/F1N307", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N307-1", "url": "https://www.uniprot.org/uniprotkb/F1N307-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSNDSSLMAGIIYYSKEKYFRHVQQAAAVGLEKFNNDPVLQFFKAYGVLREEHIQDAISSLESIRNHPDVSLCSIMALIYAHKCCETIDREAIQELESSLKEVRKTASGTALYYAGLFLWLMGRHDKAKEYIDRTLKISSSSREGYVLRGWVDLSSDKPHTVKKSIKYLEHGIQDTKDILGLMGKVMYFMILQNYSGALEVVNQITVTCGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDKSNIDACQILAVHELAREGNMTVAAEHVRNLIKALETREPENPSLHLKKILVCGRHQGILQLVCSFIERTFMATSSDAHMATELGYLFILQDQVKEASLWYSKAMKLDESSVAALTGIIWCQILDGHLEEAEHQLEFLKEVQQSLGKSKVLVFLQALLVSKKHRGEQEATTLLKEAAELHFSSMQALPMSSEYLERLDPIFLVCIAKEYLVFCPKQPRSPGQIVSPLLKQVAAILNPVVKVAPALIEPLYVMAQVKYLSGELEHAQSTLQRCLELDPTSVDTHLLMAQIYLAQGNFAMCSHSLELGVSHNFQVRDHPLYHFIKAKALNKSGDYPEAIKALKMIIKLPTLRTEENKKFRGPCVRPSERVSILLELADALRMNGELHEATKVMQDAINEFSGTPEEMRVTIANVDLALSKGSVDLALSVLQSITPRQPCYTEAKEKMASIYLQTRKDARLYIGCYRELCEHLPGPHTSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLINRIGQAYVKTHQYTKAINYYEAAQKMSGQDFVCCDLAELLLKLKKFNKAEKVLKQALDHDFVKDIPSMMNDVKCLLLLAKVYKSHKKEDVTETLNKAMDLQSRILKRVPLERPEMIPSQKQLAASICIQFGEYYLAEKEYAKAVQSYKDALSYTPINNKVVLELARLYLLQGHLDLCEQHCADLLQTEKNHEAASVVMADLMFRRQKYEAAINLYHQVLEKAPDNFPVLNKLIDLLRRSGKLEDAPAVFELAEKMSSRVPLEPGFNFCRGIYCWHIGQPNEALKFLNKARKDTAWGQSATYHMVQICLNPDNEIVGGEAFENLVTESNPSARSFSSRKELEQHGVRTAEKLLREFYPHSAGGHTQLRLLQSLCLLATREKANVEVALSTFVEMAQAEKDSVPALLAMAQACSLLKQVPKARTQLKRLAKAPWALAEADDLERSWLLLADIYCQGGKFDLASELLQRCVKYNKSCCKAYEYMGFIMEREQSYKDAAANYELAWKYSHHTNPAIGFRLAFNYLKDKRFVEAIEVCHDVLREHPNYPKIREEILEKAQGSLRP", "length": 1314, "header": "tr|A0AAA9SS91-1|A0AAA9SS91_BOVIN Isoform 1 of Tetratricopeptide repeat domain 21A OS=Bos taurus OX=9913 GN=TTC21A PE=3 SV=1 CANONICAL=A0AAA9SS91-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NAK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91/entry#A0A3Q1NAK0-1", "sequence": { "sequence": "MSSNDSSLMAGIIYYSKEKYFRHVQQAAAVGLEKFNNDPVLQFFKAYGVLREEHIQDAISSLESIRNHPDVSLCSIMALIYAHKCCETIDREAIQELESSLKEVRKTASGTALYYAGLFLWLMGRHDKAKEYIDRTLKISSSSREVMYFMILQNYSGALEVVNQITVTCGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDKSNIDACQILAVHELAREGNMTVAAEHVRNLIKALETREPENPSLHLKKILVVSRLCGRHQGILQLVCSFIERTFMATSSDAHMATELGYLFILQDQVKEASLWYSKAMKLDESSVAALTGIIWCQILDGHLEEAEHQLEFLKEVQQSLGKSKVLVFLQALLVSKKHRGEQEATTLLKEAAELHFSSMQALPMSSEYLERLDPIFLVCIAKEYLVFCPKQPRSPGQIVSPLLKQVAAILNPVVKVAPALIEPLYVMAQVKYLSGELEHAQSTLQRCLELDPTSVDTHLLMAQIYLAQGNFAMCSHSLELGVSHNFQVRDHPLYHFIKAKALNKSGDYPEAIKALKMIIKLPTLRTEENKKFRGPCVRPSERVSILLELADALRMNGELHEATKVMQDAINEFSGTPEEMRVTIANVDLALSKGSVDLALSVLQSITPRQPCYTEAKEKMASIYLQTRKDARLYIGCYRELCEHLPGPHTSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLINRIGQAYVKTHQYTKAINYYEAAQKMSGQDFVCCDLAELLLKLKKFNKAEKVLKQALDHDFVKDIPSMMNDVKCLLLLAKVYKSHKKEDVTETLNKAMDLQSRILKRVPLERPEMIPSQKQLAASICIQFGEYYLAEKEYAKAVQSYKDALSYTPINNKVVLELARLYLLQGHLDLCEQHCADLLQTEKNHEAASVVMADLMFRRQKYEAAINLYHQVLEKAPDNFPVLNKLIDLLRRSGKLEDAPAVFELAEKMSSRVPLEPGFNFCRGIYCWHIGQPNEALKFLNKARKDTAWGQSATYHMVQICLNPDNEIVGGEAFENLVTESNFSSRKELEQHGVRTAEKLLREFYPHSAGGHTQLRLLQSLCLLATREKANVEVALSTFVEMAQAEKDSVPALLAMAQACSLLKQVPKARTQLKRLAKAPWALAEADDLERSWLLLADIYCQGGKFDLASELLQRCVKYNKSCCKAYEYMGFIMEREQSYKDAAANYELAWKYSHHTNPAIGFRLAFNYLKDKRFVEAIEVCHDVLREHPNYPKIREEILEKAQGSLRP", "length": 1272, "header": "tr|A0A3Q1NAK0-1|A0AAA9SS91_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 21A OS=Bos taurus OX=9913 GN=TTC21A PE=3 SV=2 CANONICAL=A0AAA9SS91-1" }, "locus": { "chromosome": "22", "start_pos": 12475736, "end_pos": 12441515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084445.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084445.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068301.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068301.2" } ] } }, { "isoform_ac": "A0AAA9RW22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91/entry#A0AAA9RW22-1", "sequence": { "sequence": "MSSNDSSLMAGIIYYSKEKYFRHVQQAAAVGLEKFNNDPVLQFFKAYGVLREEHIQDAISSLESIRNHPDVSLCSIMALIYAHKCCETIDREAIQELESSLKEVRKTASGTALYYAGLFLWLMGRHDKAKEYIDRTLKISSSSREGYVLRGWVDLSSDKPHTVKKSIKYLEHGIQDTKDILGLMGKVMYFMILQNYSGALEVVNQITVTCGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDKSNIDACQILAVHELAREGNMTVAAEHVRNLIKALETREPENPSLHLKKILVVSRLCGRHQGILQLDQVKEASLWYSKAMKLDESSVAALTGIIWCQILDGHLEEAEHQLEFLKEVQQSLGKSKVLVFLQALLVSKKHRGEQEATTLLKEAAELHFSSMQALPMSSEYLERLDPIFLVCIAKEYLVFCPKQPRSPGQIVSPLLKQVAAILNPVVKVAPALIEPLYVMAQVKYLSGELEHAQSTLQRCLELDPTSVDTHLLMAQIYLAQGNFAMCSHSLELGVSHNFQVRDHPLYHFIKAKALNKSGDYPEAIKALKMIIKLPTLRTEENKKFRGPCVRPSERVSILLELADALRMNGELHEATKVMQDAINEFSGTPEEMRVTIANVDLALSKGSVDLALSVLQSITPRQPCYTEAKEKMASIYLQTRKDARLYIGCYRELCEHLPGPHTSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLINRIGQAYVKTHQYTKAINYYEAAQKMSGQDFVCCDLAELLLKLKKFNKAEKVLKQALDHDFVKDIPSMMNDVKCLLLLAKVYKSHKKEDVTETLNKAMDLQSRILKRVPLERPEMIPSQKQLAASICIQFGEYYLAEKEYAKAVQSYKDALSYTPINNKVVLELARLYLLQGHLDLCEQHCADLLQTEKNHEAASVVMADLMFRRQKYEAAINLYHQVLEKAPDNFPVLNKLIDLLRRSGKLEDAPAVFELAEKMSSRVPLEPGFNFCRGIYCWHIGQPNEALKFLNKARKDTAWGQSATYHMVQICLNPDNEIVGGEAFENLVTESNFSSRKELEQHGVRTAEKLLREFYPHSAGGHTQLRLLQSLCLLATREKANVEVALSTFVEMAQAEKDSVPALLAMAQACSLLKQVPKARTQLKRLAKAPWALAEADDLERSWLLLADIYCQGGKFDLASELLQRCVKYNKARGAPPSGLLQGVVCV", "length": 1212, "header": "tr|A0AAA9RW22-1|A0AAA9SS91_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 21A OS=Bos taurus OX=9913 GN=TTC21A PE=3 SV=1 CANONICAL=A0AAA9SS91-1" }, "locus": { "chromosome": "22", "start_pos": 12474771, "end_pos": 12441515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129921.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129921.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076569.1" } ] } }, { "isoform_ac": "A0AAA9SS91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91/entry#A0AAA9SS91-1", "sequence": { "sequence": "MSSNDSSLMAGIIYYSKEKYFRHVQQAAAVGLEKFNNDPVLQFFKAYGVLREEHIQDAISSLESIRNHPDVSLCSIMALIYAHKCCETIDREAIQELESSLKEVRKTASGTALYYAGLFLWLMGRHDKAKEYIDRTLKISSSSREGYVLRGWVDLSSDKPHTVKKSIKYLEHGIQDTKDILGLMGKVMYFMILQNYSGALEVVNQITVTCGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDKSNIDACQILAVHELAREGNMTVAAEHVRNLIKALETREPENPSLHLKKILVCGRHQGILQLVCSFIERTFMATSSDAHMATELGYLFILQDQVKEASLWYSKAMKLDESSVAALTGIIWCQILDGHLEEAEHQLEFLKEVQQSLGKSKVLVFLQALLVSKKHRGEQEATTLLKEAAELHFSSMQALPMSSEYLERLDPIFLVCIAKEYLVFCPKQPRSPGQIVSPLLKQVAAILNPVVKVAPALIEPLYVMAQVKYLSGELEHAQSTLQRCLELDPTSVDTHLLMAQIYLAQGNFAMCSHSLELGVSHNFQVRDHPLYHFIKAKALNKSGDYPEAIKALKMIIKLPTLRTEENKKFRGPCVRPSERVSILLELADALRMNGELHEATKVMQDAINEFSGTPEEMRVTIANVDLALSKGSVDLALSVLQSITPRQPCYTEAKEKMASIYLQTRKDARLYIGCYRELCEHLPGPHTSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLINRIGQAYVKTHQYTKAINYYEAAQKMSGQDFVCCDLAELLLKLKKFNKAEKVLKQALDHDFVKDIPSMMNDVKCLLLLAKVYKSHKKEDVTETLNKAMDLQSRILKRVPLERPEMIPSQKQLAASICIQFGEYYLAEKEYAKAVQSYKDALSYTPINNKVVLELARLYLLQGHLDLCEQHCADLLQTEKNHEAASVVMADLMFRRQKYEAAINLYHQVLEKAPDNFPVLNKLIDLLRRSGKLEDAPAVFELAEKMSSRVPLEPGFNFCRGIYCWHIGQPNEALKFLNKARKDTAWGQSATYHMVQICLNPDNEIVGGEAFENLVTESNPSARSFSSRKELEQHGVRTAEKLLREFYPHSAGGHTQLRLLQSLCLLATREKANVEVALSTFVEMAQAEKDSVPALLAMAQACSLLKQVPKARTQLKRLAKAPWALAEADDLERSWLLLADIYCQGGKFDLASELLQRCVKYNKSCCKAYEYMGFIMEREQSYKDAAANYELAWKYSHHTNPAIGFRLAFNYLKDKRFVEAIEVCHDVLREHPNYPKIREEILEKAQGSLRP", "length": 1314, "header": "tr|A0AAA9SS91-1|A0AAA9SS91_BOVIN Isoform 1 of Tetratricopeptide repeat domain 21A OS=Bos taurus OX=9913 GN=TTC21A PE=3 SV=1 CANONICAL=A0AAA9SS91-1" }, "locus": { "chromosome": "22", "start_pos": 12475736, "end_pos": 12441515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106263.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106263.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085882.1" } ] } }, { "isoform_ac": "F1N307-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91/entry#F1N307-1", "sequence": { "sequence": "MSSNDSSLMAGIIYYSKEKYFRHVQQAAAVGLEKFNNDPVLQFFKAYGVLREDREAIQELESSLKEVRKTASGTALYYAGLFLWLMGRHDKAKEYIDRTLKISSSSREGYVLRGWVDLSSDKPHTVKKSIKYLEHGIQDTKDILGLMGKVMYFMILQNYSGALEVVNQITVTCGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDKSNIDACQILAVHELAREGNMTVAAEHVRNLIKALETREPENPSLHLKKILVVSRLCGRHQGILQLVCSFIERTFMATSSDAHMATELGYLFILQDQVKEASLWYSKAMKLDESSVAALTGIIWCQILDGHLEEAEHQLEFLKEVQQSLGKSKVLVFLQALLVSKKHRGEQEATTLLKEAAELHFSSMQALPMSSEYLERLDPIFLVCIAKEYLVFCPKQPRSPGQIVSPLLKQVAAILNPVVKVAPALIEPLYVMAQVKYLSGELEHAQSTLQRCLELDPTSVDTHLLMAQIYLAQGNFAMCSHSLELGVSHNFQVRDHPLYHFIKAKALNKSGDYPEAIKALKMIIKLPTLRTEENKKFRGPCVRPSERVSILLELADALRMNGELHEATKVMQDAINEFSGTPEEMRVTIANVDLALSKGSVDLALSVLQSITPRQPCYTEAKEKMASIYLQTRKDARLYIGCYRELCEHLPGPHTSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLINRIGQAYVKTHQYTKAINYYEAAQKMSGQDFVCCDLAELLLKLKKFNKAEKVLKQALDHDFVKDIPSMMNDVKCLLLLAKVYKSHKKEDVTETLNKAMDLQSRILKRVPLERPEMIPSQKQLAASICIQFGEYYLAEKEYAKAVQSYKDALSYTPINNKVVLELARLYLLQGHLDLCEQHCADLLQTEKNHEAASVVMADLMFRRQKYEAAINLYHQVLEKAPDNFPVLNKLIDLLRRSGKLEDAPAVFELAEKMSSRVPLEPGFNFCRGIYCWHIGQPNEALKFLNKARKDTAWGQSATYHMVQICLNPDNEIVGGEAFENLVTESNFSSRKELEQHGVRTAEKLLREFYPHSAGGHTQLRLLQSLCLLATREKANVEVALSTFVEMAQAEKDSVPALLAMAQACSLLKQVPKARTQLKRLAKAPWALAEADDLERSWLLLADIYCQGGKFDLASELLQRCVKYNKSCCKAYEYMGFIMEREQSYKDAAANYELAWKYSHHTNPAIGFRLAFNYLKDKRFVEAIEVCHDVLREHPNYPKIREEILEKAQGSLRP", "length": 1276, "header": "tr|F1N307-1|F1N307_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 21A OS=Bos taurus OX=9913 GN=TTC21A PE=3 SV=4 CANONICAL=A0AAA9SS91-1" }, "locus": { "chromosome": "22", "start_pos": 12475736, "end_pos": 12441515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048382.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048382.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045433.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045433.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1225, "end_pos": 1227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" }, { "id": "PF25063", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25063" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetratricopeptide repeat protein 21A/21B C-terminal ARM", "eco_id": "ECO_0000259", "start_pos": 1101, "end_pos": 1309, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" }, { "id": "PF25062", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25062" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 234, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" }, { "id": "PF25064", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25064" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetratricopeptide repeat protein 21A/21B fifth ARM repeats", "eco_id": "ECO_0000259", "start_pos": 946, "end_pos": 1062, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" }, { "id": "PF25068", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25068" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetratricopeptide repeat protein 21A/21B fourth ARM", "eco_id": "ECO_0000259", "start_pos": 753, "end_pos": 905, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SS91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS91" }, { "id": "PF25060", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25060" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tetratricopeptide repeat protein 21A/21B second ARM", "eco_id": "ECO_0000259", "start_pos": 270, "end_pos": 538, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1225, "end_pos": 1227 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 4, "end_pos": 6 }, { "start_pos": 572, "end_pos": 574 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUZ8-1", "uniprot_ac": "A0AAA9SUZ8", "uniprot_id": "A0AAA9SUZ8_BOVIN", "mass": { "chemical_mass": 28169.0, "monoisotopic_mass": 28169.0 }, "refseq": { "ac": "XP_024845523", "name": "NBPF family member NBPF6-like protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845523" }, "gene_names": [ { "name": "MGC134040", "type": "recommended", "evidence": [ { "id": "A0AAA9SUZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8" } ] }, { "name": "MGC134040", "type": "synonym", "evidence": [ { "id": "XP_024845523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845523" } ] } ], "protein_names": [ { "name": "NBPF family member NBPF6-like protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845523" } ] }, { "name": "Neuroblastoma breakpoint family member 6-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SUZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MGC134040", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8", "locus": { "chromosome": "3", "start_pos": 20915637, "end_pos": 20935892, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022741", "url": "https://www.ensembl.org/id/ENSBTAG00000022741" } ] } } ], "crossref": [ { "id": "A0AAA9SUZ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022741", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022741", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767972", "url": "https://www.ncbi.nlm.nih.gov/gene/767972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NQYLHSQ", "url": "https://omabrowser.org/oma/group/NQYLHSQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ28", "url": "https://www.orthodb.org/?gene=A0A452DJ28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14199:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14199:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46501", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46501", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46501:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46501:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845523", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845523", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ28", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ28-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S096", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S096", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S096-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S096-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSKTHFSMAVSHTIFSGLRTEMGLLETNQYLHSQLEKSKQDFRDLTEKLLTSQATVYSLAKQLQKYKCEEYKDLIESVLEEEAPFEEGNLAEKRRLATGLGRYDSLIEAQARELTCLRQKIQEGEGVCHLFTQHAKNTIKTFESFIKTTDMTYYQRQRFCELLAQGSQMAERLASKLSTENHHDRKDEEGQESLAARLSMGLQGEEVNEVLEDSLDEKYLTHSSHHDSHRPPSSIASVCDVQDQL", "length": 246, "header": "tr|A0AAA9SUZ8-1|A0AAA9SUZ8_BOVIN Isoform 1 of Neuroblastoma breakpoint family member 6-like protein OS=Bos taurus OX=9913 GN=MGC134040 PE=3 SV=1 CANONICAL=A0AAA9SUZ8-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8/entry#A0A452DJ28-1", "sequence": { "sequence": "MAVSHTIFSGLRTEMGLLETNQYLHSQLEKSKQDFRDLTEKLLTSQATVYSLAKQLQKYKCEEYKDLIESVLEEEAPFEEGNLAEKRRLATGLGRYDSLIEAQARELTCLRQKIQEGEGVCHLFTQHAKNTIKTFESFIKTTDMTYYQRQRFCELLAQGSQMAERLASKLSTENHHDRKDEEGQESLAARLSMGLQGEEVNEVLEDSLDEKYLTHSSHHDSHRPPSSIASVCDVQDQL", "length": 238, "header": "tr|A0A452DJ28-1|A0AAA9SUZ8_BOVIN Computationally mapped isoform of Neuroblastoma breakpoint family member 6-like protein OS=Bos taurus OX=9913 GN=MGC134040 PE=3 SV=1 CANONICAL=A0AAA9SUZ8-1" }, "locus": { "chromosome": "3", "start_pos": 20928743, "end_pos": 20919102, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030870.3", "url": "https://www.ensembl.org/id/ENSBTAT00000030870.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030838.3", "url": "https://www.ensembl.org/id/ENSBTAP00000030838.3" } ] } }, { "isoform_ac": "A0AAA9S096-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8/entry#A0AAA9S096-1", "sequence": { "sequence": "MRRTEHLAVQGKPVPFKSSCLCDVVLCVCLVRRKCEEYKDLIESVLEEEAPFEEGNLAEKRRLATGLGRYDSLIEAQARELTCLRQKIQEGEGVCHLFTQHAKNTIKTFESFIKTTDMTYYQRQRFCELLAQGSQMAERLASKLSTENHHDRKDEEGQESLAARLSMGLQGEEVNEVLEDSLDEKYLTHSSHHDSHRPPSSIASVCDVQDQL", "length": 212, "header": "tr|A0AAA9S096-1|A0AAA9SUZ8_BOVIN Computationally mapped isoform of Neuroblastoma breakpoint family member 6-like protein OS=Bos taurus OX=9913 GN=MGC134040 PE=3 SV=1 CANONICAL=A0AAA9SUZ8-1" }, "locus": { "chromosome": "3", "start_pos": 20935602, "end_pos": 20919102, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095274.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095274.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078373.1" } ] } }, { "isoform_ac": "A0AAA9SUZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8/entry#A0AAA9SUZ8-1", "sequence": { "sequence": "MSSKTHFSMAVSHTIFSGLRTEMGLLETNQYLHSQLEKSKQDFRDLTEKLLTSQATVYSLAKQLQKYKCEEYKDLIESVLEEEAPFEEGNLAEKRRLATGLGRYDSLIEAQARELTCLRQKIQEGEGVCHLFTQHAKNTIKTFESFIKTTDMTYYQRQRFCELLAQGSQMAERLASKLSTENHHDRKDEEGQESLAARLSMGLQGEEVNEVLEDSLDEKYLTHSSHHDSHRPPSSIASVCDVQDQL", "length": 246, "header": "tr|A0AAA9SUZ8-1|A0AAA9SUZ8_BOVIN Isoform 1 of Neuroblastoma breakpoint family member 6-like protein OS=Bos taurus OX=9913 GN=MGC134040 PE=3 SV=1 CANONICAL=A0AAA9SUZ8-1" }, "locus": { "chromosome": "3", "start_pos": 20935519, "end_pos": 20919102, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121326.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121326.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087785.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087785.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUZ8" }, { "id": "PS51316", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51316" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Olduvai", "eco_id": "ECO_0000259", "start_pos": 181, "end_pos": 246, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVK9-1", "uniprot_ac": "A0AAA9SVK9", "uniprot_id": "A0AAA9SVK9_BOVIN", "mass": { "chemical_mass": 42833.0, "monoisotopic_mass": 42833.0 }, "refseq": { "ac": "NP_001179360", "name": "stomatin-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179360" }, "gene_names": [ { "name": "STOML1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ] }, { "name": "STOML1", "type": "synonym", "evidence": [ { "id": "NP_001179360", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179360" } ] } ], "protein_names": [ { "name": "Stomatin-like protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9/entry#names_and_taxonomy" } ] }, { "name": "stomatin (EPB72)-like 1", "type": "synonym", "evidence": [ { "id": "NP_001179360", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179360" } ] }, { "name": "stomatin-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179360", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179360" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STOML1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9", "locus": { "chromosome": "21", "start_pos": 34648679, "end_pos": 34633259, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015772", "url": "https://www.ensembl.org/id/ENSBTAG00000015772" } ] } } ], "crossref": [ { "id": "A0AAA9SVK9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVK9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015772", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015772", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13436", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13436", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540438", "url": "https://www.ncbi.nlm.nih.gov/gene/540438", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001107", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001107", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540438", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540438", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AMHFLSH", "url": "https://omabrowser.org/oma/group/AMHFLSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAV3", "url": "https://www.orthodb.org/?gene=E1BAV3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10264", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10264", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10264:SF130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10264:SF130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179360", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RRQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAV3", "url": "https://www.uniprot.org/uniprotkb/E1BAV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAV3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGGVGPGADAPQSWPSCFCHGLISFLGFLLLLITFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFSVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPSLDSTLQQLALHFLGGSVPSVAGGAPRPGPADTLEMVSEVEPSAPHGGAGPSPKQPVAEGLLMALKPILSEALVSQVGACYQFNVILPSGPQSIYFLDLTAGQGRVGHGVPDVIPDVVVELSEEDLRSLLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLKALK", "length": 398, "header": "tr|A0AAA9SVK9-1|A0AAA9SVK9_BOVIN Isoform 1 of Stomatin-like protein 1 OS=Bos taurus OX=9913 GN=STOML1 PE=3 SV=1 CANONICAL=A0AAA9SVK9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RRQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9/entry#A0AAA9RRQ5-1", "sequence": { "sequence": "MLSRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGGVGPGADAPQSWPSCFCHGLISFLGFLLLLITFPISGWFALKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPSLDSTLQQLALHFLGGSVPSVAGGAPRPGPADTLEMVSEVEPSAPHGGAGPSPKQPVAEGLLMALKPILSEALVSQVGACYQFNVILPSGPQSIYFLDLTAGQGRVGHGVPDVIPDVVVELSEEDLRSLLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLKALK", "length": 348, "header": "tr|A0AAA9RRQ5-1|A0AAA9SVK9_BOVIN Computationally mapped isoform of Stomatin-like protein 1 OS=Bos taurus OX=9913 GN=STOML1 PE=3 SV=1 CANONICAL=A0AAA9SVK9-1" }, "locus": { "chromosome": "21", "start_pos": 34641523, "end_pos": 34633272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092712.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092712.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074881.1" } ] } }, { "isoform_ac": "A0AAA9SVK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9/entry#A0AAA9SVK9-1", "sequence": { "sequence": "MLSRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGGVGPGADAPQSWPSCFCHGLISFLGFLLLLITFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFSVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPSLDSTLQQLALHFLGGSVPSVAGGAPRPGPADTLEMVSEVEPSAPHGGAGPSPKQPVAEGLLMALKPILSEALVSQVGACYQFNVILPSGPQSIYFLDLTAGQGRVGHGVPDVIPDVVVELSEEDLRSLLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLKALK", "length": 398, "header": "tr|A0AAA9SVK9-1|A0AAA9SVK9_BOVIN Isoform 1 of Stomatin-like protein 1 OS=Bos taurus OX=9913 GN=STOML1 PE=3 SV=1 CANONICAL=A0AAA9SVK9-1" }, "locus": { "chromosome": "21", "start_pos": 34641523, "end_pos": 34633272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101689.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101689.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090516.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090516.1" } ] } }, { "isoform_ac": "A0AAA9TV52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9/entry#A0AAA9TV52-1", "sequence": { "sequence": "MLSRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGGVGPGADAPQSWPSCFCHGLISFLGFLLLLITFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFSVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPSLDSTLQQLALHFLGGSVPSVAGGAPRPGPADTLEMVSEVEPSAPHGGAGPSPKQPVAEGLLMALKPILSEALVSQVGACYQFNVILPSGPQSIYFLDLTAGQGRVGHGVPDVIPDVVVELSEEDLRSLLCRELRPLGAYMSGRLKCSSEVLQCSYGLEHFFKVYSQAKWSPAPPTRTARDDWSTDGMTEHQQVPRRTSQRDLWQDWAQNLCLMAPAHDFLFHQWGLWGSGIGME", "length": 468, "header": "tr|A0AAA9TV52-1|A0AAA9TV52_BOVIN Computationally mapped isoform of Stomatin like 1 OS=Bos taurus OX=9913 GN=STOML1 PE=3 SV=1 CANONICAL=A0AAA9SVK9-1" }, "locus": { "chromosome": "21", "start_pos": 34648661, "end_pos": 34633272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131978.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131978.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101274.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101274.1" } ] } }, { "isoform_ac": "E1BAV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9/entry#E1BAV3-1", "sequence": { "sequence": "MLSRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGGVGPGADAPQSWPSCFCHGLISFLGFLLLLITFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFSVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPSLDSTLQQLALHFLGGSVPSVAGGAPRPGPGQGRVGHGVPDVIPDVVVELSEEDLRSLLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLKALK", "length": 327, "header": "tr|E1BAV3-1|E1BAV3_BOVIN Computationally mapped isoform of Stomatin like 1 OS=Bos taurus OX=9913 GN=STOML1 PE=3 SV=3 CANONICAL=A0AAA9SVK9-1" }, "locus": { "chromosome": "21", "start_pos": 34641523, "end_pos": 34633272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020941.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020941.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020941.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020941.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540438", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540438", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZHG1-1", "protein_name": "Stomatin like 1", "gene_name": "STOML1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFSRSGYQALPLGDFDRFQQSSIGLYGAQKGFFSFGAKADPLGPAMNAADSSQGWLSWICHGIITSLVFLLMLLTFPISGWFALKIVPTYERMVIFRLGRLRAPQGPGVVLLLPFIDHWQRVDLRTRAFNVPPCKLISRDGAVLSMGADVQFRVWDPALSVLVVKDLVAATRMTAQSAMAKALGKKSLREIQGEKLRIGEQLLLDINDMTKSWGLEVDRVELTMEAVLQPPRDALLGPLGAVAPALEGSPPQLAAHLLNSTPSAPEAADSVGTVSEVEPPRRRPSAVELLSAVEPILSEALVSQVGASYQVDIILPGGARSTFFIDLSSGSGRAGCGVPQGSPDVVLEVAEEDLQELMLGELRPLAAYMSGRLRVQGDLQLALRLEELFKAVKLHR", "length": 396 }, "evidence": [ { "id": "A0AAA9SVK9", "url": "https://omabrowser.org/oma/group/A0AAA9SVK9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A7E9-1", "protein_name": "Stomatin-like protein 1", "gene_name": "Stoml1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGGVGPGADAPESWPSCLCHGLISFLGFLLLLLTFPISGWFALKIVPTYERMIVFRLGRIRNPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMAVKDLNAATRMTAHNAMTKALLRRPLQEIQMEKLKIGDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSLAVPSLDSTLQQLALHFLGGSMTSVGRVPSPGSDTLEMINEVEPPASRAGAGTEPSPKQPVAEGLLTALQPFLSESLVSQVGACYQFNVLLPSGTQSIYFLDLTTGQGRVGHGVPDGIPDVVVEMAEADLQALLCKELRPLGAYMSGRLKVKGDLAVVMKLEAVLKALK", "length": 398 }, "evidence": [ { "id": "A0AAA9SVK9", "url": "https://omabrowser.org/oma/group/A0AAA9SVK9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HEI5-1", "protein_name": "Stomatin-like protein 1", "gene_name": "Stoml1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFGRSGYRALPLGDFDRFQQSSFGFVGSQKGCLSPEPSGVGPGADAPESWPSCLCHGLISFLGFLLLLLTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMAVKDLNTATRMTARNAMTKALLRKSLQEIQMEKLKIGDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAVPSLDSTLQQLALHLLGGSMNSAVGGAPSSGPVDTLEMISEVEPPACLAGTGPEPSPKQPVAEGLLTALQPFLSEALVSQVGACYQFNVILPSGTQSIYFLDLTAGQGRVGHGAPDGIPDVVVEMAEADLQALLCRELRPLGAYMSGRLKVKGDLAVVMKLEAVLRALK", "length": 400 }, "evidence": [ { "id": "A0AAA9SVK9", "url": "https://omabrowser.org/oma/group/A0AAA9SVK9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8CI66-1", "protein_name": "Stomatin-like protein 1", "gene_name": "Stoml1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPEPGSVGPGADAPESWPSCLCHGLVSVLGFLLLLLTFPISGWFALKIVPTYERMIVFRLGRIRNPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMAVKDLNTATRMTAHNAMTKALLRRPLQEIQMEKLKIGDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSLTVPSLDSTLQQLALHLLGGSMNSAVGRVPSPGPDTLEMINEVEPPASLAGAGAEPSPKQPVAEGLLTALQPFLSEALVSQVGACYQFNVILPSGTQSIYFLDLTTGQGRVGHGEPDGIPDVVVEMAEADLQALLSKELRPLGAYMSGRLKVKGDLAVVMKLEAVLKALK", "length": 399 }, "evidence": [ { "id": "A0AAA9SVK9", "url": "https://omabrowser.org/oma/group/A0AAA9SVK9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UBI4-1", "protein_name": "Stomatin-like protein 1", "gene_name": "STOML1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPERGGVGTGADVPQSWPSCLCHGLISFLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMAGGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTALQPFLSEALVSQVGACYQFNVVLPSGTQSAYFLDLTTGRGRVGHGVPDGIPDVVVEMAEADLRALLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLRALK", "length": 398 }, "evidence": [ { "id": "A0AAA9SVK9", "url": "https://omabrowser.org/oma/group/A0AAA9SVK9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ion channel inhibitor activity", "id": "GO:0008200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK9" }, { "id": "SM00244", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00244" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Band 7", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 242, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUU0-1", "uniprot_ac": "A0AAA9SUU0", "uniprot_id": "A0AAA9SUU0_BOVIN", "mass": { "chemical_mass": 125119.0, "monoisotopic_mass": 125119.0 }, "refseq": {}, "gene_names": [ { "name": "MYO1H", "type": "recommended", "evidence": [ { "id": "A0AAA9SUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" } ] } ], "protein_names": [ { "name": "Myosin IH", "type": "synonym", "evidence": [ { "id": "A0AAA9SUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYO1H", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0", "locus": { "chromosome": "17", "start_pos": 63726438, "end_pos": 63815336, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002695", "url": "https://www.ensembl.org/id/ENSBTAG00000002695" } ] } } ], "crossref": [ { "id": "A0AAA9SUU0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUU0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002695", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01378", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01378", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N7D5", "url": "https://www.orthodb.org/?gene=F1N7D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140:SF353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140:SF353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RRW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S850", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S850", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S850-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S850-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7D5", "url": "https://www.uniprot.org/uniprotkb/F1N7D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7D5-1", "url": "https://www.uniprot.org/uniprotkb/F1N7D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSTLFFFLEEYEIHLLSWLYGPLSFASGYREPQIDSDFASGPASLLKEEVRRKHIRLHVEGALTARDKVGVQDFVLLDAYTSESAFLDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTLSQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLFSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGIPVGGHIISYLIEKSRVVYQNQGERNFHIFYQLLEGGEEELLAYLGLERDPQLYKYLSQGRCAKESSVNDKNDWKTVSNAFSVIDFTKDDLENLFGIIASVLHLGNIGFEENQQGCASVPDTHEIKWIAKLLGVDPWVLLEALTHRKIEAKTEEVICPLTLELSAYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTGKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIQYFNNKIICDLVEERHKGIISILDEECVRPGPATDLSFLERLEEKVGKHAHFETRKLAGPRGRKKIGWMEFRLFHYAGEVTYCARGFLEKNNDLLYRHLKEVLCRSKNRILKECFLVAELENRRRAPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNESKEPSKFDDFLIRHQVKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPEEGVERLIKYIGYKPEEYKLGRTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLERRAYVRKRQAAITLEAHWRGALARKEAKRRKWAVQTVRKFIKGFINRNKPLCPDNEEFIVFVRKNYILNLRHHVPKNVLDKSWLRPPGILETASDLLRKMCTRNLVRKYCHGITAERRALMQEKVVMSEIFEGKKEGYTESLHQPFANSRVDEGDINPKVLQLLSSEKIQYGVPVIKYDRKGFKTRQRQLILTQKAAYVVELAKIKQKIEYPALKGVSTSSLSDGILVIHILQADIKQKGDVILQCEHIFEAVTKLAMLVKKENLVNVVQGRSRKMQMFIDSPCLPLPEKEALPTCNNFLPSSAPRTRAPEK", "length": 1082, "header": "tr|A0AAA9SUU0-1|A0AAA9SUU0_BOVIN Isoform 1 of Myosin IH OS=Bos taurus OX=9913 GN=MYO1H PE=3 SV=1 CANONICAL=A0AAA9SUU0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RRW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0/entry#A0AAA9RRW4-1", "sequence": { "sequence": "MHLLHRKADSPPLDQKEEVRRKHIRLHVEGALTARDKVGVQDFVLLDAYTSESAFLDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTLSQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLFSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGIPVGGHIISYLIEKSRVVYQNQGERNFHIFYQLLEGGEEELLAYLGLERDPQLYKYLSQGRCAKESSVNDKNDWKTVSNAFSVIDFTKDDLENLFGIIASVLHLGNIGFEENQQGCASVPDTHEIKWIAKLLGVDPWVLLEALTHRKIEAKTEEVICPLTLELSAYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTGKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIQYFNNKIICDLVEERHKGIISILDEECVRPGPATDLSFLERLEEKVGKHAHFETRKLAGPRGRKKIGWMEFRLFHYAGEVTYCARGFLEKNNDLLYRHLKEVLCRSKNRILKECFLVAELENRRRAPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNESKEPSKFDDFLIRHQVKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPEEGVERLIKYIGYKPEEYKLGRTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLERRAYVRKRQAAITLEAHWRGALARKEAKRRKWAVQTVRKFIKGFINRNKPLCPDNEEFIVFVRKNYILNLRHHVPKNVLDKSWLRPPGILETASDLLRKMCTRNLVRKYCHGITAERRALMQEKVVMSEIFEGKKEGYTESLHQPFANSRVDEGDINPKVLQLLSSEKIQYGVPVIKYDRKGFKTRQRQLILTQKAAYVVELAKIKQKIEYPALKGVSTSSLSDGILVIHILQADIKQKGDVILQCEHIFEAVTKLAMLVKKENLVNVVQGRSRKMQMFIDSPCLPLPEKEALPTCNNFLPSSAPRTRAPEK", "length": 1049, "header": "tr|A0AAA9RRW4-1|A0AAA9SUU0_BOVIN Computationally mapped isoform of Myosin IH OS=Bos taurus OX=9913 GN=MYO1H PE=3 SV=1 CANONICAL=A0AAA9SUU0-1" }, "locus": { "chromosome": "17", "start_pos": 63774333, "end_pos": 63728814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113938.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113938.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075007.1" } ] } }, { "isoform_ac": "A0AAA9S850-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0/entry#A0AAA9S850-1", "sequence": { "sequence": "MHLLHRKADSPPLDQKEEVRRKHIRLHVEGALTARDKVGVQDFVLLDAYTSESAFLDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTLSQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLFSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGIPVGGHIISYLIEKSRVVYQNQGERNFHIFYQLLEGGEEELLAYLGLERDPQLYKYLSQGRCAKESSVNDKNDWKTVSNAFSVIDFTKDDLENLFGIIASVLHLGNIGFEENQQGCASVPDTHEIKWIAKLLGVDPWVLLEALTHRKIEAKTEEVICPLTLELSAYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTGKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIQYFNNKIICDLVEERHKGIISILDEECVRPGPATDLSFLERLEEKVGKHAHFETRKLAGPRGRKKIGWMEFRLFHYAGEVTYCARGFLEKNNDLLYRHLKEVLCRSKNRILKECFLVAELENRRRAPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNESKEPSKFDDFLIRHQVKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPEEGVERLIKYIGYKPEEYKLGRTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLERRAYVRKRQAAITLEAHWRGALARKEAKRRKWAVQTVRKFIKGFINRNKPLCPDNEEFIVFVRKNYILNLRHHVPKNVLDKSWLRPPGILETASDLLRKMCTRNLVRKYCHGITAERRALMQEKVVMSEIFEGKKEGYTESLHQPFANSRVDEGDINPKVLQLLSSEKIQYGVPVIKYDRKGFKTRQRQLILTQKAAYVVELAKIKQKIEYPALKGVSTSSLSDGILVIHILQADIKQKGDVILQCEHIFEAVTKLAMLVKKENLVNVVQGSLQFCISPGKEGTIVFDTGPEEQIYKDKNGQLTVVSVCPKS", "length": 1049, "header": "tr|A0AAA9S850-1|A0AAA9SUU0_BOVIN Computationally mapped isoform of Myosin IH OS=Bos taurus OX=9913 GN=MYO1H PE=3 SV=1 CANONICAL=A0AAA9SUU0-1" }, "locus": { "chromosome": "17", "start_pos": 63774333, "end_pos": 63727065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095799.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095799.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082217.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082217.1" } ] } }, { "isoform_ac": "A0AAA9SUU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0/entry#A0AAA9SUU0-1", "sequence": { "sequence": "MADSTLFFFLEEYEIHLLSWLYGPLSFASGYREPQIDSDFASGPASLLKEEVRRKHIRLHVEGALTARDKVGVQDFVLLDAYTSESAFLDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTLSQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLFSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGIPVGGHIISYLIEKSRVVYQNQGERNFHIFYQLLEGGEEELLAYLGLERDPQLYKYLSQGRCAKESSVNDKNDWKTVSNAFSVIDFTKDDLENLFGIIASVLHLGNIGFEENQQGCASVPDTHEIKWIAKLLGVDPWVLLEALTHRKIEAKTEEVICPLTLELSAYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTGKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIQYFNNKIICDLVEERHKGIISILDEECVRPGPATDLSFLERLEEKVGKHAHFETRKLAGPRGRKKIGWMEFRLFHYAGEVTYCARGFLEKNNDLLYRHLKEVLCRSKNRILKECFLVAELENRRRAPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNESKEPSKFDDFLIRHQVKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPEEGVERLIKYIGYKPEEYKLGRTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLERRAYVRKRQAAITLEAHWRGALARKEAKRRKWAVQTVRKFIKGFINRNKPLCPDNEEFIVFVRKNYILNLRHHVPKNVLDKSWLRPPGILETASDLLRKMCTRNLVRKYCHGITAERRALMQEKVVMSEIFEGKKEGYTESLHQPFANSRVDEGDINPKVLQLLSSEKIQYGVPVIKYDRKGFKTRQRQLILTQKAAYVVELAKIKQKIEYPALKGVSTSSLSDGILVIHILQADIKQKGDVILQCEHIFEAVTKLAMLVKKENLVNVVQGRSRKMQMFIDSPCLPLPEKEALPTCNNFLPSSAPRTRAPEK", "length": 1082, "header": "tr|A0AAA9SUU0-1|A0AAA9SUU0_BOVIN Isoform 1 of Myosin IH OS=Bos taurus OX=9913 GN=MYO1H PE=3 SV=1 CANONICAL=A0AAA9SUU0-1" }, "locus": { "chromosome": "17", "start_pos": 63815235, "end_pos": 63728814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110205.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110205.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089110.1" } ] } }, { "isoform_ac": "A0AAA9TSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0/entry#A0AAA9TSS7-1", "sequence": { "sequence": "MADSTLFFFLEEYEIHLLSWLYGPLSFASGYREPQIDSDFASGPASLLKEEVRRKHIRLHVEGALTARDKVGVQDFVLLDAYTSESAFLDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTLSQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLFSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGIPVGGHIISYLIEKSRVVYQNQGERNFHIFYQLLEGGEEELLAYLGLERDPQLYKYLSQGRCAKESSVNDKNDWKTVSNAFSVIDFTKDDLELLGVDPWVLLEALTHRKIEAKTEEVICPLTLELSAYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTGKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIQYFNNKIICDLVEERHKGIISILDEECVRPGPATDLSFLERLEEKVGKHAHFETRKLAGPRGRKKIGWMEFRLFHYAGEVTYCARGFLEKNNDLLYRHLKEVLCRSKNRILKECFLVAELENRRRAPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNESKEPSKFDDFLIRHQVKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPEEGVERLIKYIGYKPEEYKLGRTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLERRAYVRKRQAAITLEAHWRGALARKEAKRRKWAVQTVRKFIKGFINRNKPLCPDNEEFIVFVRKNYILNLRHHVPKNVLDKSWLRPPGILETASDLLRKMCTRNLVRKYCHGITAERRALMQEKVVMSEIFEGKKEGYTESLHQPFANSRVDEGDINPKVLQLLSSEKIQYGVPVIKYDRKGFKTRQRQLILTQKAAYVVELAKIKQKIEYPALKGVSTSSLSDGILVIHILQADIKQKGDVILQCEHIFEAVTKLAMLVKKENLVNVVQGRSRKMQMFIDSPCLPLPEKEALPTCNNFLPSSAPRTRAPEK", "length": 1044, "header": "tr|A0AAA9TSS7-1|A0AAA9TSS7_BOVIN Computationally mapped isoform of Myosin IH OS=Bos taurus OX=9913 GN=MYO1H PE=3 SV=1 CANONICAL=A0AAA9SUU0-1" }, "locus": { "chromosome": "17", "start_pos": 63815235, "end_pos": 63728814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132898.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132898.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101435.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101435.1" } ] } }, { "isoform_ac": "F1N7D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0/entry#F1N7D5-1", "sequence": { "sequence": "MGSKKEEVRRKHIRLHVEGALTARDKVGVQDFVLLDAYTSESAFLDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTLSQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDRLLFSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGIPVGGHIISYLIEKSRVVYQNQGERNFHIFYQLLEGGEEELLAYLGLERDPQLYKYLSQGRCAKESSVNDKNDWKTVSNAFSVIDFTKDDLENLFGIIASVLHLGNIGFEENQQGCASVPDTHEIKWIAKLLGVDPWVLLEALTHRKIEAKTEEVICPLTLELSAYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTGKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIQYFNNKIICDLVEERHKGIISILDEECVRPGPATDLSFLERLEEKVGKHAHFETRKLAGPRGRKKIGWMEFRLFHYAGEVTYCARGFLEKNNDLLYRHLKEVLCRSKNRILKECFLVAELENRRRAPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNESKEPSKFDDFLIRHQVKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPEEGVERLIKYIGYKPEEYKLGRTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLERRAYVRKRQAAITLEAHWRGALARKEAKRRKWAVQTVRKFIKGFINRNKPLCPDNEEFIVFVRKNYILNLRHHVPKNVLDKSWLRPPGILETASDLLRKMCTRNLVRKYCHGITAERRALMQEKVVMSEIFEGKKEGYTESLHQPFANSRVDEGDINPKVLQLLSSEKIQYGVPVIKYDRKGFKTRQRQLILTQKAAYVVELAKIKQKIEYPALKGVSTSSLSDGILVIHILQADIKQKGDVILQCEHIFEAVTKLAMLVKKENLVNVVQGSLQFCISPGKEGTIVFDTGPEEQIYKDKNGQLTVVSVCPKS", "length": 1038, "header": "tr|F1N7D5-1|F1N7D5_BOVIN Computationally mapped isoform of Myosin IH OS=Bos taurus OX=9913 GN=MYO1H PE=3 SV=4 CANONICAL=A0AAA9SUU0-1" }, "locus": { "chromosome": "17", "start_pos": 63791426, "end_pos": 63727065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003490.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003490.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003490.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003490.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 649, "end_pos": 651, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" }, { "id": "PS51456", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51456" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin motor", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 751, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUU0" }, { "id": "PS51757", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51757" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TH1", "eco_id": "ECO_0000259", "start_pos": 905, "end_pos": 1082, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 219, "end_pos": 221 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 649, "end_pos": 651 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVC7-1", "uniprot_ac": "A0AAA9SVC7", "uniprot_id": "A0AAA9SVC7_BOVIN", "mass": { "chemical_mass": 15453.0, "monoisotopic_mass": 15453.0 }, "refseq": {}, "gene_names": [ { "name": "LOC515276", "type": "recommended", "evidence": [ { "id": "A0AAA9SVC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7" } ] } ], "protein_names": [ { "name": "Galectin", "type": "recommended", "evidence": [ { "id": "A0AAA9SVC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC515276", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SVC7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047030", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047030", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00070", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00070", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515276", "url": "https://www.ncbi.nlm.nih.gov/gene/515276", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515276", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515276", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RSP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2E2", "url": "https://www.uniprot.org/uniprotkb/G3N2E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2E2-1", "url": "https://www.uniprot.org/uniprotkb/G3N2E2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 135, "header": "tr|A0AAA9SVC7-1|A0AAA9SVC7_BOVIN Isoform 1 of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#A0AAA9RSP4-1", "sequence": { "sequence": "MSNPGSSAHGILQPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 147, "header": "tr|A0AAA9RSP4-1|A0AAA9SVC7_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49292279, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074644.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074644.1" } ] } }, { "isoform_ac": "A0AAA9RXZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#A0AAA9RXZ3-1", "sequence": { "sequence": "MTVPPHPQPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 142, "header": "tr|A0AAA9RXZ3-1|A0AAA9SVC7_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49290153, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093379.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093379.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078409.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078409.1" } ] } }, { "isoform_ac": "A0AAA9SJH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#A0AAA9SJH6-1", "sequence": { "sequence": "MGRPSFGHLLQTDSHTQFQQGRKAQMETMDCLPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 166, "header": "tr|A0AAA9SJH6-1|A0AAA9SVC7_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49289592, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101103.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101103.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082750.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082750.1" } ] } }, { "isoform_ac": "A0AAA9SVC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#A0AAA9SVC7-1", "sequence": { "sequence": "MPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 135, "header": "tr|A0AAA9SVC7-1|A0AAA9SVC7_BOVIN Isoform 1 of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49290478, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100076.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100076.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088142.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088142.1" } ] } }, { "isoform_ac": "A0AAA9TIG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#A0AAA9TIG4-1", "sequence": { "sequence": "MSEQRPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 139, "header": "tr|A0AAA9TIG4-1|A0AAA9TIG4_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49290698, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134473.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134473.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096011.1" } ] } }, { "isoform_ac": "A0AAA9TKX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#A0AAA9TKX1-1", "sequence": { "sequence": "MAFIGHLLQTDSHTQFQQGRKAQMETMDCLPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 164, "header": "tr|A0AAA9TKX1-1|A0AAA9TKX1_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=1 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49283858, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102567.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102567.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096928.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096928.1" } ] } }, { "isoform_ac": "G3N2E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7/entry#G3N2E2-1", "sequence": { "sequence": "MDCSPPGSSVHRISQPNPYQQSVSLAVGFMVKIMGNLESSCGKNPELVVDFCTGIEEDSDIAFHFRVYTNSMVVMNSFQKGGWQEEKRMFSDPFMPGQPFELRFLVLENEYKVFVNNESFCQFAHRLPLQSVKMLKVKGDTVLTSVDTF", "length": 149, "header": "tr|G3N2E2-1|G3N2E2_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LOC515276 PE=4 SV=3 CANONICAL=A0AAA9SVC7-1" }, "locus": { "chromosome": "18", "start_pos": 49287995, "end_pos": 49282028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064343.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064343.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056054.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056054.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515276", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515276", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC7" }, { "id": "PS51304", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51304" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Galectin", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 135, "start_aa": "Asn", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW93-1", "uniprot_ac": "A0AAA9SW93", "uniprot_id": "A0AAA9SW93_BOVIN", "mass": { "chemical_mass": 43290.0, "monoisotopic_mass": 43290.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM116", "type": "recommended", "evidence": [ { "id": "A0AAA9SW93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ] } ], "protein_names": [ { "name": "Transmembrane protein 116", "type": "synonym", "evidence": [ { "id": "A0AAA9SW93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM116", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93", "locus": { "chromosome": "17", "start_pos": 62183726, "end_pos": 62141773, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006659", "url": "https://www.ensembl.org/id/ENSBTAG00000006659" } ] } } ], "crossref": [ { "id": "A0AAA9SW93", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW93", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514512", "url": "https://www.ncbi.nlm.nih.gov/gene/514512", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514512", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514512", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YTISYIW", "url": "https://omabrowser.org/oma/group/YTISYIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B984", "url": "https://www.orthodb.org/?gene=E1B984", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BA96", "url": "https://www.orthodb.org/?gene=E1BA96", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23112:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23112:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9RSR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B984", "url": "https://www.uniprot.org/uniprotkb/E1B984", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B984-1", "url": "https://www.uniprot.org/uniprotkb/E1B984-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA96", "url": "https://www.uniprot.org/uniprotkb/E1BA96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA96-1", "url": "https://www.uniprot.org/uniprotkb/E1BA96-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPERRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQPCLWLQKSLYCTTTCSSWGNGIPWTEEPGRLLVHGVSRVGHDLVTKPPPPPINQSMESVNIFGILVTYYSRIWNHCQPQST", "length": 379, "header": "tr|A0AAA9SW93-1|A0AAA9SW93_BOVIN Isoform 1 of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9RSR6-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPEVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 287, "header": "tr|A0AAA9RSR6-1|A0AAA9SW93_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131966.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131966.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074693.1" } ] } }, { "isoform_ac": "A0AAA9RT19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9RT19-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPERRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQYHFHVISLVYLLTSGEGNGNPIQYSSLENPMDRGAWQAFSPWSLKSRT", "length": 346, "header": "tr|A0AAA9RT19-1|A0AAA9SW93_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62182626, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102811.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102811.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075932.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075932.1" } ] } }, { "isoform_ac": "A0AAA9RW01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9RW01-1", "sequence": { "sequence": "MAFLLETSILEDSWDLFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPERRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 364, "header": "tr|A0AAA9RW01-1|A0AAA9SW93_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62151557, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094859.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094859.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075280.1" } ] } }, { "isoform_ac": "A0AAA9S1Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9S1Y4-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALRRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 329, "header": "tr|A0AAA9S1Y4-1|A0AAA9SW93_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100421.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100421.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077695.1" } ] } }, { "isoform_ac": "A0AAA9SW93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9SW93-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPERRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQPCLWLQKSLYCTTTCSSWGNGIPWTEEPGRLLVHGVSRVGHDLVTKPPPPPINQSMESVNIFGILVTYYSRIWNHCQPQST", "length": 379, "header": "tr|A0AAA9SW93-1|A0AAA9SW93_BOVIN Isoform 1 of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62182747, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131465.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131465.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089601.1" } ] } }, { "isoform_ac": "A0AAA9TDT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9TDT6-1", "sequence": { "sequence": "MLGGIGGRRRRRRQRMRWLDGITDSMDMSRRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 340, "header": "tr|A0AAA9TDT6-1|A0AAA9TDT6_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62156384, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096294.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096294.1" } ] } }, { "isoform_ac": "A0AAA9TGP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9TGP7-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPEVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 322, "header": "tr|A0AAA9TGP7-1|A0AAA9TGP7_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=2 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102458.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102458.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096227.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096227.2" } ] } }, { "isoform_ac": "A0AAA9TWR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#A0AAA9TWR4-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPERRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 331, "header": "tr|A0AAA9TWR4-1|A0AAA9TWR4_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=1 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101615.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101615.1" } ] } }, { "isoform_ac": "E1B984-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#E1B984-1", "sequence": { "sequence": "MVVRPFLPLPKSDIRPALFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPEVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQIFLGPHVVSSFTFPSLALSVASKISVLHHHVFFMGKWLGPEKRVEFDFRL", "length": 304, "header": "tr|E1B984-1|E1B984_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=4 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62224890, "end_pos": 62142549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052812.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052812.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053033.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053033.4" } ] } }, { "isoform_ac": "E1BA96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93/entry#E1BA96-1", "sequence": { "sequence": "MELPRVRTRRSPHGSRFFSAIQWIQFVMATLSVIGSSSLVAYAIFQNIQKSPERRPLFYLSFSDLLLGIYWLTEALLYGTSTASKDIVCYNLQVVGQVLYISSFFYTINYIWYLYKELRMKPSQSAQRTFSLVIDYTCRIGQIAIILSSLIPLLLMVPVFCLGNVSECFRNFSQSHRCILIYSPPPAMAELLPSANTSVCSTLYFYGLIIFLASFVLSFFTIVVLLIQAQILYKKFLKSTGFLGSEQWAVIHIMEQRVRFYPVAFFCCWSPVVILMIIKLTKLQDTRLHMALYVLQALTTSSQGLLNCGVYGWTQYKFYQLKQEARRDADTQTPLLCSQKRFYCRGLDPLESTLAFATSTSTIL", "length": 364, "header": "tr|E1BA96-1|E1BA96_BOVIN Computationally mapped isoform of Transmembrane protein 116 OS=Bos taurus OX=9913 GN=TMEM116 PE=4 SV=4 CANONICAL=A0AAA9SW93-1" }, "locus": { "chromosome": "17", "start_pos": 62178955, "end_pos": 62142077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055673.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055673.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051611.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051611.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514512", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514512", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BB11-1", "protein_name": "Transmembrane protein 116", "gene_name": "TMEM116", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYKFFSAIQWIQFVMATLSVIGSSSLIAYAIFQNIQKSPEIRPIFYLSFSDLLLGICWLMEALLYGTSAASKDIFCYNLQAVGQIFYISSFLYTVYYIWYLYKELRMKHNQSGQSTFLPVIDHTYQVGQIVIVLSSLIPLLLMIPVFCLGNASECFRNFSQSHRCILMYSPPSAMAELLPSANTSVCSTLYFYGLIIFLASFLLSLFIIVVLLIQAQALFKKFVKSTGFLGSEQWAAIHIVEQQVLFYPVAFFCCWGPAAILMIIKLMKPQDTKLHMALYVLQALTGSSQGLLNCGVYGWTQYKFHQLKQKARRDADTQTPLLCSQKRFYSRGLSPLESTLAFATSTSDIF", "length": 351 }, "evidence": [ { "id": "A0AAA9SW93", "url": "https://omabrowser.org/oma/group/A0AAA9SW93/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7JLW7-1", "protein_name": "Transmembrane protein 116 isoform X1", "gene_name": "Tmem116", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MILYIASLLYTVNYIWYLYSELRMKHSQSGQSTAAQLIDHTCQSGNIVFILSSLIPLLLMTPVFCLGNVNGCFHNSSQSHRCVLMHSPPSAMIELLPSTNTSVCSTLYFYGVTVFLTSFFFSLLIITVLLLHAQTLYKKFVKSTGFLESEQWAVIYIVGQRVRFFPVAFVCCWGPAVTLLIIKLVKPQDTSLHMAFSVLQALTAASQGLLNCGIYGWTQCKFQQLKRELRCDADTQTPLLCSQKRIYCRSLALGPPDSSLTFAPSSSTIL", "length": 270 }, "evidence": [ { "id": "A0AAA9SW93", "url": "https://omabrowser.org/oma/group/A0AAA9SW93/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LUC5-1", "protein_name": "Transmembrane protein 116", "gene_name": "Tmem116", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGADLGSPRLLVIILHACFLFPAIQWIQFAVATLSVIGSSSLITYIVFQNPQKSAEVKSLLYLSFSDLLLGICWLIKALVYGTAAAHKDSICYNLQTAGEIFYLASLVFTVSYIWCLYAELRRKHSPSEQSTAAQVTDYACQGGCVMFLLSSLTPLLLMTPVFFLGNVNECFHNFSQNHRCMLMHSEPLPSTNTSVCSTLYLYGVTVFLASFFFSLLTIVVLLVLAQTLYKKFVKSMGLLESEQWAVIHTVGQRVRFFPAAFVCCWGPAVTLLIMKLTKPQETSLHVALSVLQALTAASQGLLNCGIYGWTQCKFQQIKREPPRDADTQTPLLCSQKRVYSRSPSASRPPLAFASSSSTVL", "length": 362 }, "evidence": [ { "id": "A0AAA9SW93", "url": "https://omabrowser.org/oma/group/A0AAA9SW93/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2BGS3-1", "protein_name": "Transmembrane protein 116", "gene_name": "tmem116", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDIFGENKTQMNTTTPTENWTSVYSIVRWIQMTMAVLSILGAGSIILYAAFQRLVKKPEVLPLFLLSLTDLLLALSWLCGGLLFTQSCNSYATCYNLHIVEQTLYMASFFYTLHYVWVLYTGLNGKYHRRLNGFPAEAARTRNCRCLGPVLSCLLPLLLTAPVFVAGNVFQCYTNFTQPYRCLLMHTGAVYLTSSASPELTACSIIQEYCMAIFLGTFLITIVGMSIFMGKARSLYKRVVTSQGFFGGSHWTTLRLLERRMVLYPSAFFFCWGPALLLATMMLVKPDVIEGKMGVALYILQAFTSASQGLLNCLVYGWTQKHFRSLSSSTVRDANTQTPLLRSQKPNYAALHSAASLTNFV", "length": 361 }, "evidence": [ { "id": "A0AAA9SW93", "url": "https://omabrowser.org/oma/group/A0AAA9SW93/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3X9M9-1", "protein_name": "Transmembrane protein 116", "gene_name": "Tmem116", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFPLETSRLEGRWEPLFPAIQWIQFAVATLSVIGSSSLLTYIAFQSPQKSAEIKPLLYLSFSDLLLGICWLVKALLYGTAAAHKDSICYNLQTVGEIFYLASLLYTVSYIWCLYSELRRKSGQSERSTVAQVTDYVCQGGHILFLLSSLIPPLLMTPVFLLGNVNECFHNFSESHRCILMHSPPSATPEPLPSTNTSVCSTLYFYGVTIFLASFFFSFLTIMVLLVHAQMLYKKFVKSTGLLESEQWAVIHTVGQRVRFFPVAFVCCWGPAVTLLIMKLTEPQETFLHMALSVLQALTAASQGLLNCGIYGWTQCKFQQIKREPHRDADTQTPLLCSQKRIYSRSPNLLESPLALASSSSTVL", "length": 364 }, "evidence": [ { "id": "A0AAA9SW93", "url": "https://omabrowser.org/oma/group/A0AAA9SW93/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NCL8-1", "protein_name": "Transmembrane protein 116", "gene_name": "TMEM116", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKHTQSGQSTSPLVIDYTCRVCQMAFVFSSLIPLLLMTPVFCLGNTSECFQNFSQSHKCILMHSPPSAMAELPPSANTSVCSTLYFYGIAIFLGSFVLSLLTIMVLLIRAQTLYKKFVKSTGFLGSEQWAVIHIVDQRVRFYPVAFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPASTSTIF", "length": 245 }, "evidence": [ { "id": "A0AAA9SW93", "url": "https://omabrowser.org/oma/group/A0AAA9SW93/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 173, "end_pos": 175 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 351, "end_pos": 353 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVG5-1", "uniprot_ac": "A0AAA9SVG5", "uniprot_id": "A0AAA9SVG5_BOVIN", "mass": { "chemical_mass": 54993.0, "monoisotopic_mass": 54993.0 }, "refseq": {}, "gene_names": [ { "name": "KPTN", "type": "recommended", "evidence": [ { "id": "A0AAA9SVG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ] } ], "protein_names": [ { "name": "Kaptin, actin binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SVG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KPTN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5", "locus": { "chromosome": "18", "start_pos": 54446551, "end_pos": 54457888, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030769", "url": "https://www.ensembl.org/id/ENSBTAG00000030769" } ] } } ], "crossref": [ { "id": "A0AAA9SVG5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "533926", "url": "https://www.ncbi.nlm.nih.gov/gene/533926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15435", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15435", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15435:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15435:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9RTU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R0P7", "url": "https://www.uniprot.org/uniprotkb/F6R0P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R0P7-1", "url": "https://www.uniprot.org/uniprotkb/F6R0P7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGEAAMAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGTSRRLSALGCQSGYVRVAHVDQQSRDVLQTWTIIQDGPISRVIVFSLSAPEETEDRPQREEYSVLVASMLEPAVVYRDLLSRGLEDQLLLPGSDQFDSVLCGLVTDIDLDGRPEVLVATYGQELLCYKYCGPGRGLPGDQHGFRLLWRRGFSSPLLAMAHVDLTGDGLRELAVVSLKGVHILQHSLIQASELVLTRLRRQVEQRRRQPQKMGDRRNQTHTRLHRFVRQAFDEGPRCARLNVRSWISPEELREGTLGTGDPKSDPGVGLKWNCSVDFREKKGS", "length": 493, "header": "tr|A0AAA9SVG5-1|A0AAA9SVG5_BOVIN Isoform 1 of Kaptin, actin binding protein OS=Bos taurus OX=9913 GN=KPTN PE=4 SV=1 CANONICAL=A0AAA9SVG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5/entry#A0AAA9RTU9-1", "sequence": { "sequence": "ALKQSLEGSPAGGHLCKGQRRQLLHVIGLRAPRVPGDPRSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGTSRRLSALGCQSGYVRVAHVDQQSRDVLQTWTIIQDGPISRVIVFSLSAPEETEDRPQREEYSVLVASMLEPAVVYRDLLSRGLEDQLLLPGSDQFDSVLCGLVTDIDLDGRPEVLVATYGQELLCYKYCGPGRGLPGDQHGFRLLWRRGFSSPLLAMAHVDLTGDGLRELAVVSLKGVHILQHSLIQASELVLTRLRRQVEQRRRQPQKMGDRVGSGPAETLAS", "length": 450, "header": "tr|A0AAA9RTU9-1|A0AAA9SVG5_BOVIN Computationally mapped isoform of Kaptin, actin binding protein OS=Bos taurus OX=9913 GN=KPTN PE=4 SV=1 CANONICAL=A0AAA9SVG5-1" }, "locus": { "chromosome": "18", "start_pos": 54457888, "end_pos": 54449524, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089189.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089189.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076499.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076499.1" } ] } }, { "isoform_ac": "A0AAA9SVG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5/entry#A0AAA9SVG5-1", "sequence": { "sequence": "MMGEAAMAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGTSRRLSALGCQSGYVRVAHVDQQSRDVLQTWTIIQDGPISRVIVFSLSAPEETEDRPQREEYSVLVASMLEPAVVYRDLLSRGLEDQLLLPGSDQFDSVLCGLVTDIDLDGRPEVLVATYGQELLCYKYCGPGRGLPGDQHGFRLLWRRGFSSPLLAMAHVDLTGDGLRELAVVSLKGVHILQHSLIQASELVLTRLRRQVEQRRRQPQKMGDRRNQTHTRLHRFVRQAFDEGPRCARLNVRSWISPEELREGTLGTGDPKSDPGVGLKWNCSVDFREKKGS", "length": 493, "header": "tr|A0AAA9SVG5-1|A0AAA9SVG5_BOVIN Isoform 1 of Kaptin, actin binding protein OS=Bos taurus OX=9913 GN=KPTN PE=4 SV=1 CANONICAL=A0AAA9SVG5-1" }, "locus": { "chromosome": "18", "start_pos": 54457724, "end_pos": 54449056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117341.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117341.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088183.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088183.1" } ] } }, { "isoform_ac": "A0AAA9SX92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5/entry#A0AAA9SX92-1", "sequence": { "sequence": "MMGEAAMAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGTSRRLSALGCQSGYVRVAHVDQQSRDVLQTWTIIQDGPISRVIVFSLSAPEETEDRPQREEYSVLVASMLEPAVVYRDLLSRGLEDQLLLPGSDQFDSVLCGLVTDIDLDGRPEVLVATYGQELLCYKYCGPGRGLPGDQHGFRLLWRRGFSSPLLAMAHVDLTGDGLRELAVVSLKGVHILQHSLIQASELVLTRLRRQVEQRRRQPQKMGDRDL", "length": 427, "header": "tr|A0AAA9SX92-1|A0AAA9SX92_BOVIN Computationally mapped isoform of Kaptin, actin binding protein OS=Bos taurus OX=9913 GN=KPTN PE=4 SV=1 CANONICAL=A0AAA9SVG5-1" }, "locus": { "chromosome": "18", "start_pos": 54457724, "end_pos": 54447065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110625.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110625.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088693.1" } ] } }, { "isoform_ac": "F6R0P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5/entry#F6R0P7-1", "sequence": { "sequence": "MMGEAAMAAGPCPLREDSFTRFSSQSNVYGLAGGAGGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAQSCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGTSRRLSALGCQSGYVRVAHVDQQSRDVLQTWTIIQDGPISRVIVFSLSAPEETEDRPQREEYSVLVASMLEPAVVYRDLLSRGLEDQLLLPGSDQFDSVLCGLVTDIDLDGRPEVLVATYGQELLCYKYCGPGRGLPGDQHGFRLLWRRGFSSPLLAMAHVDLTGDGLRELAVVSLKGVHILQPDPGLRAGPDPASASSGAEETSATEDGGQGGFRACRDPGFLSTHSLPTPSLK", "length": 446, "header": "tr|F6R0P7-1|F6R0P7_BOVIN Computationally mapped isoform of Kaptin, actin binding protein OS=Bos taurus OX=9913 GN=KPTN PE=4 SV=1 CANONICAL=A0AAA9SVG5-1" }, "locus": { "chromosome": "18", "start_pos": 54457724, "end_pos": 54449489, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043487.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043487.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041053.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041053.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "cellular response to glucose starvation", "id": "GO:0042149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "protein localization to lysosome", "id": "GO:0061462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061462", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "KICSTOR complex", "id": "GO:0140007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140007", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "postsynaptic actin cytoskeleton", "id": "GO:0098871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" }, { "name": "filamentous actin", "id": "GO:0031941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 427, "end_pos": 429, "annotation": "n_glycosylation_sequon" }, { "start_pos": 482, "end_pos": 484, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 427, "end_pos": 429 }, { "start_pos": 482, "end_pos": 484 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV79-1", "uniprot_ac": "A0AAA9SV79", "uniprot_id": "A0AAA9SV79_BOVIN", "mass": { "chemical_mass": 142764.0, "monoisotopic_mass": 142764.0 }, "refseq": { "ac": "XP_059743726", "name": "adhesion G protein-coupled receptor A3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743726" }, "gene_names": [ { "name": "ADGRA3", "type": "recommended", "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ] }, { "name": "ADGRA3", "type": "synonym", "evidence": [ { "id": "XP_059743726", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743726" } ] } ], "protein_names": [ { "name": "Adhesion G protein-coupled receptor A3", "type": "recommended", "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 125", "type": "synonym", "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#names_and_taxonomy" } ] }, { "name": "adhesion G protein-coupled receptor A3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059743726", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743726" } ] } ], "function": [ { "annotation": "Orphan receptor that may have a role in planar cell polarity pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LLW7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW7#function" }, { "database": "UniProtKB", "id": "ARBA00053087", "url": "https://www.uniprot.org/uniprotkb/ARBA00053087#function" }, { "database": "UniProtKB", "id": "A0A3Q1MWA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA5#function" }, { "database": "UniProtKB", "id": "A0AAA9RV04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV04#function" }, { "database": "UniProtKB", "id": "F1MK80", "url": "https://www.uniprot.org/uniprotkb/F1MK80#function" }, { "database": "UniProtKB", "id": "A0AAA9SB43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB43#function" }, { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79#function" }, { "database": "UniProtKB", "id": "A0AAA9SYT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT6#function" }, { "database": "UniProtKB", "id": "A0AAA9T3D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D3#function" }, { "database": "UniProtKB", "id": "A0AAA9T487", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T487#function" }, { "database": "UniProtKB", "id": "A0AAA9TAZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADGRA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79", "locus": { "chromosome": "6", "start_pos": 41983734, "end_pos": 42122645, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004653", "url": "https://www.ensembl.org/id/ENSBTAG00000004653" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004653", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004653", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15999", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15999", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541147", "url": "https://www.ncbi.nlm.nih.gov/gene/541147", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541147", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541147", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LLW7", "url": "https://www.orthodb.org/?gene=A0A3Q1LLW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MWA5", "url": "https://www.orthodb.org/?gene=A0A3Q1MWA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MK80", "url": "https://www.orthodb.org/?gene=F1MK80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45930", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45930", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45930:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45930:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26588", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26588", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059743726", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743726", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLW7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLW7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWA5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3D3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T487", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T487", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T487-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T487-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK80", "url": "https://www.uniprot.org/uniprotkb/F1MK80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK80-1", "url": "https://www.uniprot.org/uniprotkb/F1MK80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERPGRPRGRPPPPLLLLPLALLALLGGGAVALPPGCKHDGRLRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1291, "header": "tr|A0AAA9SV79-1|A0AAA9SV79_BOVIN Isoform 1 of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0A3Q1LLW7-1", "sequence": { "sequence": "MKSCTFDPRFLGILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1247, "header": "tr|A0A3Q1LLW7-1|A0A3Q1LLW7_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=2 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42115979, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069292.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069292.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060827.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060827.2" } ] } }, { "isoform_ac": "A0A3Q1MWA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0A3Q1MWA5-1", "sequence": { "sequence": "MRKKFGVRKENLCILLSMVGNSWGEGEMDDGRILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1267, "header": "tr|A0A3Q1MWA5-1|A0A3Q1MWA5_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=2 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42112006, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069838.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069838.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059648.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059648.2" } ] } }, { "isoform_ac": "A0AAA9RV04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9RV04-1", "sequence": { "sequence": "MVFNLTQINPSRIYGILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1250, "header": "tr|A0AAA9RV04-1|A0AAA9SV79_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42115526, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102618.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102618.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076057.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076057.1" } ] } }, { "isoform_ac": "A0AAA9SB43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9SB43-1", "sequence": { "sequence": "MERPGRPRGRPPPPLLLLPLALLALLGGGAVALPPGCKHDGRLRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLEDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1270, "header": "tr|A0AAA9SB43-1|A0AAA9SV79_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42116814, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098765.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098765.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082590.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082590.1" } ] } }, { "isoform_ac": "A0AAA9SV79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9SV79-1", "sequence": { "sequence": "MERPGRPRGRPPPPLLLLPLALLALLGGGAVALPPGCKHDGRLRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1291, "header": "tr|A0AAA9SV79-1|A0AAA9SV79_BOVIN Isoform 1 of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42116814, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101609.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101609.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087093.1" } ] } }, { "isoform_ac": "A0AAA9SYT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9SYT6-1", "sequence": { "sequence": "MERPGRPRGRPPPPLLLLPLALLALLGGGAVALPPGCKHDGRLRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1289, "header": "tr|A0AAA9SYT6-1|A0AAA9SYT6_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42116814, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129822.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129822.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090534.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090534.1" } ] } }, { "isoform_ac": "A0AAA9T3D3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9T3D3-1", "sequence": { "sequence": "MNITDSCCGLNSCGSRILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1251, "header": "tr|A0AAA9T3D3-1|A0AAA9T3D3_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42111447, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109825.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109825.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093303.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093303.1" } ] } }, { "isoform_ac": "A0AAA9T487-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9T487-1", "sequence": { "sequence": "MRRGDELALLKSREGFRTIGLSVVFQAPGWSRILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1267, "header": "tr|A0AAA9T487-1|A0AAA9T487_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42112423, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125991.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125991.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091323.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091323.1" } ] } }, { "isoform_ac": "A0AAA9TAZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#A0AAA9TAZ5-1", "sequence": { "sequence": "MNITDSCCGLNSCGSRILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLEDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1206, "header": "tr|A0AAA9TAZ5-1|A0AAA9TAZ5_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=1 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42111447, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100707.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100707.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095168.1" } ] } }, { "isoform_ac": "F1MK80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79/entry#F1MK80-1", "sequence": { "sequence": "MYLETPITSRILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNAHGSGIYPGNAQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLGLAQREAKACSRIVQCLQRIATYRLANGAHVYSTYSPNIALEAYVIKATGFTGMTCTVFQKVAATDRTGLSDYGRRDLDGNLDKQLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKREVRPSDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNIDTHHIPVNVTLRRIAHGADAVAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQAAHLLHPVVYTTAVILLLCLLAVIVSYIYHHSLIRISLKGWHMLVNLCFHIFLTCVVFVGGISQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDELPPPPRPMLRFYLIGGGIPVIVCGITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEVNHQDSMSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYYPLDLVFSFFFGATCLSLSAFIVVHHCVNREDVRLAWIMTCCPGRSTYSVQVNVQPPSSSGPSGEAPKCTNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHTNSLPLNATPQLDNSLTEHSMDNDIKMHVAPLEVPFRTNMHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRLGSNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTSSKKDAVRKPTVVELESQQKSYGLNLAIQNGPIKSSGQEGPLLGTDSTGNVRTGLWKHETTV", "length": 1245, "header": "tr|F1MK80-1|F1MK80_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A3 OS=Bos taurus OX=9913 GN=ADGRA3 PE=3 SV=4 CANONICAL=A0AAA9SV79-1" }, "locus": { "chromosome": "6", "start_pos": 42122561, "end_pos": 41984738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006107.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006107.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006107.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006107.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541147", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541147", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1070, "end_pos": 1072, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1078, "end_pos": 1080, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1103, "end_pos": 1105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1144, "end_pos": 1146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 562, "end_pos": 564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 657, "end_pos": 659, "annotation": "n_glycosylation_sequon" }, { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" }, { "start_pos": 791, "end_pos": 793, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" }, { "id": "PS50227", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50227" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 1", "eco_id": "ECO_0000259", "start_pos": 293, "end_pos": 388, "start_aa": "Gly", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 729, "end_pos": 1020, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" }, { "id": "PS50221", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50221" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAIN-B", "eco_id": "ECO_0000259", "start_pos": 553, "end_pos": 720, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SV79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV79" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 310, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 1070, "end_pos": 1072 }, { "start_pos": 1078, "end_pos": 1080 }, { "start_pos": 1103, "end_pos": 1105 }, { "start_pos": 1144, "end_pos": 1146 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 271, "end_pos": 273 }, { "start_pos": 302, "end_pos": 304 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 562, "end_pos": 564 }, { "start_pos": 622, "end_pos": 624 }, { "start_pos": 657, "end_pos": 659 }, { "start_pos": 698, "end_pos": 700 }, { "start_pos": 75, "end_pos": 77 }, { "start_pos": 791, "end_pos": 793 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVM0-1", "uniprot_ac": "A0AAA9SVM0", "uniprot_id": "A0AAA9SVM0_BOVIN", "mass": { "chemical_mass": 88593.0, "monoisotopic_mass": 88593.0 }, "refseq": { "ac": "XP_024844447", "name": "paraneoplastic antigen Ma6E", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844447" }, "gene_names": [ { "name": "PNMA6E", "type": "recommended", "evidence": [ { "id": "A0AAA9SVM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0" } ] }, { "name": "PNMA6E", "type": "synonym", "evidence": [ { "id": "XP_024844447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844447" } ] } ], "protein_names": [ { "name": "PNMA family member 6F", "type": "recommended", "evidence": [ { "id": "A0AAA9SVM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#names_and_taxonomy" } ] }, { "name": "paraneoplastic antigen Ma6E", "type": "synonym", "evidence": [ { "id": "XP_024844447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844447" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PNMA6E", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SVM0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVM0", "database": "AlphaFoldDB", "categories": [] }, { "id": "112445121", "url": "https://www.ncbi.nlm.nih.gov/gene/112445121", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112445121", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445121", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23095", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23095", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23095:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23095:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20846", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20846", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844447", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844447", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RV41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGTGEVRAADEGAAGDVGRTGEVGAAGEEGAAGDVGGIGEVGAAGEEEATGDVGGTGEVAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 886, "header": "tr|A0AAA9SVM0-1|A0AAA9SVM0_BOVIN Isoform 1 of PNMA family member 6F OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RV41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#A0AAA9RV41-1", "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 816, "header": "tr|A0AAA9RV41-1|A0AAA9SVM0_BOVIN Computationally mapped isoform of PNMA family member 6F OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "locus": { "chromosome": "X", "start_pos": 36648213, "end_pos": 36645556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130323.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130323.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074848.1" } ] } }, { "isoform_ac": "A0AAA9SL12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#A0AAA9SL12-1", "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGRTGEVGAAGEEGAAGDVGGIGEVGAAGEEEATGDVGGTGEVAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 851, "header": "tr|A0AAA9SL12-1|A0AAA9SVM0_BOVIN Computationally mapped isoform of PNMA family member 6F OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "locus": { "chromosome": "X", "start_pos": 36648213, "end_pos": 36645556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122137.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122137.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084588.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084588.1" } ] } }, { "isoform_ac": "A0AAA9SVM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#A0AAA9SVM0-1", "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGTGEVRAADEGAAGDVGRTGEVGAAGEEGAAGDVGGIGEVGAAGEEEATGDVGGTGEVAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 886, "header": "tr|A0AAA9SVM0-1|A0AAA9SVM0_BOVIN Isoform 1 of PNMA family member 6F OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "locus": { "chromosome": "X", "start_pos": 36648213, "end_pos": 36645556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132890.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132890.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090533.1" } ] } }, { "isoform_ac": "A0AAA9T4G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#A0AAA9T4G4-1", "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAADEGAAGDVGRTGEVGAAGEEGAAGDVGGIGEVGAAGEEEATGDVGGTGEVAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 875, "header": "tr|A0AAA9T4G4-1|A0AAA9T4G4_BOVIN Computationally mapped isoform of PNMA family member 6F OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "locus": { "chromosome": "X", "start_pos": 36648213, "end_pos": 36645556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091401.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091401.1" } ] } }, { "isoform_ac": "A0AAA9TM79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#A0AAA9TM79-1", "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 810, "header": "tr|A0AAA9TM79-1|A0AAA9TM79_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "locus": { "chromosome": "X", "start_pos": 36648213, "end_pos": 36645556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133353.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133353.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098353.1" } ] } }, { "isoform_ac": "A0AAA9TYD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0/entry#A0AAA9TYD5-1", "sequence": { "sequence": "MVKPLALLRDWCRWMGVNEERSVLLLGIPDDCEDQEFRDAVQAALGPLGRYRVLGKVFRKDLGSKIALVEFAEYLSRSLIPRQIPGKGGPWIVVCLPQAPDAESQDRPNFPAQPQRRAVVGRVGEARATGDVGGTGEVGAAGVEGAAGDVGGTGEVGAAGEEEATGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGTGEVGAAGEEGAAGDVGGIGEVGAAGEEGTSKEGTSSENGPTGEEGAAGEIGDAGEERAAGEIDAGEEGAAGMEGAAGENGPTGEAGASSENGPACEEGATDEEGAAGEAGAAGQAGAGFEGRATSEAGGTGEEGTADEEGAADEAGGIGEADTADEAGVAGEAGAESEARAEDEAGTSDEEGAAGDTGVAGVAGSLSLAGAAGEAGVPMEAAAAGIAGAMDEPRARSPQWWLALEPVLENMGYLELRTFSGMEEPDEGEESFESWLDHANDMLYLWRHVTEMERRRRLVESLGGPALDLLCSLLEEDPNLTAQDCLTALVEAFGSKDPRVTARLKFMMCAQRPQESLFAFVMRLEGLLQLALGKGAVHPAIADQLRARQVLMRARPNNLMQNKLKRMRMERRPPSFVAMLQLIRETETWETDPAMGEQLPVEEEAHGVLGDLAAALGHVIITEGAAAGGSEASPASGDTSAQVAFSKEGGVEALPTREEASKAVGSSAEVAQAAPEARGAARAASAPGETTQEDGRAPSPLGLGQAAPSEAPWSPPTAWVGGASPVVPGSPGWEPEGLPQVGDQEAEEPPKKGFKPIPEEPEDEEGAVEMSPLGFSSGQ", "length": 834, "header": "tr|A0AAA9TYD5-1|A0AAA9TYD5_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=PNMA6E PE=4 SV=1 CANONICAL=A0AAA9SVM0-1" }, "locus": { "chromosome": "X", "start_pos": 36648213, "end_pos": 36645556, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090191.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090191.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103363.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112445121", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445121", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0" }, { "id": "PF14893", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Paraneoplastic antigen Ma-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 526, "end_pos": 687, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SVM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM0" }, { "id": "PF20846", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20846" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Paraneoplastic antigen Ma-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 94, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 586, "end_pos": 588 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSF0-1", "uniprot_ac": "A0AAA9SSF0", "uniprot_id": "A0AAA9SSF0_BOVIN", "mass": { "chemical_mass": 72407.0, "monoisotopic_mass": 72407.0 }, "refseq": { "ac": "NP_001178294", "name": "sec1 family domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178294" }, "gene_names": [ { "name": "SCFD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SSF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ] }, { "name": "SCFD1", "type": "synonym", "evidence": [ { "id": "NP_001178294", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178294" } ] } ], "protein_names": [ { "name": "Sec1 family domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SSF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#names_and_taxonomy" } ] }, { "name": "Syntaxin-binding protein 1-like 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SSF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#names_and_taxonomy" } ] }, { "name": "sec1 family domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001178294", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178294" } ] } ], "function": [ { "annotation": "Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi.", "evidence": [ { "database": "UniProtKB", "id": "E1BG76", "url": "https://www.uniprot.org/uniprotkb/E1BG76#function" }, { "database": "UniProtKB", "id": "ARBA00055860", "url": "https://www.uniprot.org/uniprotkb/ARBA00055860#function" }, { "database": "UniProtKB", "id": "A0AAA9RXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXC4#function" }, { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0#function" }, { "database": "UniProtKB", "id": "A0AAA9T6X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6X4#function" }, { "database": "UniProtKB", "id": "A0AAA9TCW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW4#function" }, { "database": "UniProtKB", "id": "A0AAA9TDB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB5#function" }, { "database": "UniProtKB", "id": "A0AAA9TRH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRH6#function" }, { "database": "UniProtKB", "id": "A0AAA9TYT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYT4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCFD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0", "locus": { "chromosome": "21", "start_pos": 41381804, "end_pos": 41268756, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017565", "url": "https://www.ensembl.org/id/ENSBTAG00000017565" } ] } } ], "crossref": [ { "id": "A0AAA9SSF0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017565", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017565", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100140328", "url": "https://www.ncbi.nlm.nih.gov/gene/100140328", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001619", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001619", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140328", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140328", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BG76", "url": "https://www.orthodb.org/?gene=E1BG76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11679", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11679", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00995", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00995", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178294", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6X4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6X4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6X4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG76", "url": "https://www.uniprot.org/uniprotkb/E1BG76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG76-1", "url": "https://www.uniprot.org/uniprotkb/E1BG76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGAKMAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 641, "header": "tr|A0AAA9SSF0-1|A0AAA9SSF0_BOVIN Isoform 1 of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9RXC4-1", "sequence": { "sequence": "MVGAKMAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKQEKKIHRWMSQSFRIIRHLQGSYLSRREHASECGPPLKSVYNTLVSGKHPSYTEMSFIPFSVHIARIGLHDQAQRQKARERNRNQV", "length": 697, "header": "tr|A0AAA9RXC4-1|A0AAA9SSF0_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41371185, "end_pos": 41268777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097631.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097631.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075798.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075798.1" } ] } }, { "isoform_ac": "A0AAA9S5L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9S5L8-1", "sequence": { "sequence": "MAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 586, "header": "tr|A0AAA9S5L8-1|A0AAA9SSF0_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133772.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133772.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077466.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077466.1" } ] } }, { "isoform_ac": "A0AAA9SDB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9SDB1-1", "sequence": { "sequence": "MAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 595, "header": "tr|A0AAA9SDB1-1|A0AAA9SSF0_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129117.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129117.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081537.1" } ] } }, { "isoform_ac": "A0AAA9SSF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9SSF0-1", "sequence": { "sequence": "MVGAKMAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 641, "header": "tr|A0AAA9SSF0-1|A0AAA9SSF0_BOVIN Isoform 1 of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087042.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087042.1" } ] } }, { "isoform_ac": "A0AAA9T6X4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9T6X4-1", "sequence": { "sequence": "MVGAKMAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDRQLFLWWEEATTLNIKIWLTT", "length": 598, "header": "tr|A0AAA9T6X4-1|A0AAA9T6X4_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41370270, "end_pos": 41268777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096273.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096273.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091541.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091541.1" } ] } }, { "isoform_ac": "A0AAA9TCW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9TCW4-1", "sequence": { "sequence": "MAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 585, "header": "tr|A0AAA9TCW4-1|A0AAA9TCW4_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134498.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134498.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094584.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094584.1" } ] } }, { "isoform_ac": "A0AAA9TDB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9TDB5-1", "sequence": { "sequence": "MAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 507, "header": "tr|A0AAA9TDB5-1|A0AAA9TDB5_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115615.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115615.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094747.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094747.1" } ] } }, { "isoform_ac": "A0AAA9TRH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9TRH6-1", "sequence": { "sequence": "MAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 606, "header": "tr|A0AAA9TRH6-1|A0AAA9TRH6_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=1 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111160.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111160.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099053.1" } ] } }, { "isoform_ac": "A0AAA9TYT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#A0AAA9TYT4-1", "sequence": { "sequence": "MVGAKMAGAAAASIRERQTVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 619, "header": "tr|A0AAA9TYT4-1|A0AAA9TYT4_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=2 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41268777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126421.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126421.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102397.2", "url": "https://www.ensembl.org/id/ENSBTAP00000102397.2" } ] } }, { "isoform_ac": "E1BG76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0/entry#E1BG76-1", "sequence": { "sequence": "MWCWRKCFRVALKRMLNFNVPHVKNSTGEPVWKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRICQDLRNQLYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQRPLLVLIDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGMENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISAQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFAKMASAPTSYGNTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK", "length": 631, "header": "tr|E1BG76-1|A0AAA9SSF0_BOVIN Computationally mapped isoform of Sec1 family domain-containing protein 1 OS=Bos taurus OX=9913 GN=SCFD1 PE=3 SV=4 CANONICAL=A0AAA9SSF0-1" }, "locus": { "chromosome": "21", "start_pos": 41381596, "end_pos": 41269030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046085.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046085.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043412.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043412.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140328", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140328", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "negative regulation of autophagosome assembly", "id": "GO:1902902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "regulation of protein transport", "id": "GO:0051223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "response to toxic substance", "id": "GO:0009636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 627, "end_pos": 629, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 35, "end_pos": 37 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 576, "end_pos": 578 }, { "start_pos": 627, "end_pos": 629 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST46-1", "uniprot_ac": "A0AAA9ST46", "uniprot_id": "A0AAA9ST46_BOVIN", "mass": { "chemical_mass": 38605.0, "monoisotopic_mass": 38605.0 }, "refseq": {}, "gene_names": [ { "name": "ZPBP", "type": "recommended", "evidence": [ { "id": "A0AAA9ST46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ] } ], "protein_names": [ { "name": "Zona pellucida binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9ST46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46", "locus": {} } ], "crossref": [ { "id": "A0AAA9ST46", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005499", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005499", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N369", "url": "https://www.orthodb.org/?gene=F1N369", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15443", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15443", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15443:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15443:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07354", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07354", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20626", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20626", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N369", "url": "https://www.uniprot.org/uniprotkb/F1N369", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N369-1", "url": "https://www.uniprot.org/uniprotkb/F1N369-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEASAPGRARRGWRRARAAGSPLSRAAMVLVVSALVLWAPPSVGYLDRLPRSAQLPQDSVKIVGSPNIPVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCVLQSPLDCKEIQQVHSEADQP", "length": 340, "header": "tr|A0AAA9ST46-1|A0AAA9ST46_BOVIN Isoform 1 of Zona pellucida binding protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9ST46-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#A0AAA9RYF0-1", "sequence": { "sequence": "MSRWMRLLKHPPLKAGVGYLDRLPRSAQLPQDSVKIVGSPNIPVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCVICSPGSYNSRDGIHCLQCNSSLVFGAKACL", "length": 324, "header": "tr|A0AAA9RYF0-1|A0AAA9ST46_BOVIN Computationally mapped isoform of Zona pellucida binding protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9ST46-1" }, "locus": { "chromosome": "4", "start_pos": 5961325, "end_pos": 5810189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116011.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116011.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077636.1" } ] } }, { "isoform_ac": "A0AAA9RZ12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#A0AAA9RZ12-1", "sequence": { "sequence": "MEASAPGRARRGWRRARAAGSPLSRAAMVLVVSALVLWAPPSVGYLDRLPRSAQLPQDSVKIVGSPNIPVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCDFLQ", "length": 323, "header": "tr|A0AAA9RZ12-1|A0AAA9ST46_BOVIN Computationally mapped isoform of Zona pellucida binding protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9ST46-1" }, "locus": { "chromosome": "4", "start_pos": 5965067, "end_pos": 5809912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094495.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094495.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076544.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076544.1" } ] } }, { "isoform_ac": "A0AAA9SEN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#A0AAA9SEN6-1", "sequence": { "sequence": "MEASAPGRARRGWRRARAAGSPLSRAAMVLVVSALVLWAPPSVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCVICSPGSYNSRDGIHCLQCNSSLVFGAKACL", "length": 323, "header": "tr|A0AAA9SEN6-1|A0AAA9ST46_BOVIN Computationally mapped isoform of Zona pellucida binding protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9ST46-1" }, "locus": { "chromosome": "4", "start_pos": 5961325, "end_pos": 5809912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098798.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098798.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082305.1" } ] } }, { "isoform_ac": "A0AAA9ST46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#A0AAA9ST46-1", "sequence": { "sequence": "MEASAPGRARRGWRRARAAGSPLSRAAMVLVVSALVLWAPPSVGYLDRLPRSAQLPQDSVKIVGSPNIPVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCVLQSPLDCKEIQQVHSEADQP", "length": 340, "header": "tr|A0AAA9ST46-1|A0AAA9ST46_BOVIN Isoform 1 of Zona pellucida binding protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9ST46-1" }, "locus": { "chromosome": "4", "start_pos": 5938404, "end_pos": 5809912, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118758.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118758.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087159.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087159.1" } ] } }, { "isoform_ac": "A0AAA9TPV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#A0AAA9TPV7-1", "sequence": { "sequence": "MENKRCLPDGRKEIVGYLDRLPRSAQLPQDSVKIVGSPNIPVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCVICSPGSYNSRDGIHCLQCNSSLVFGAKACL", "length": 322, "header": "tr|A0AAA9TPV7-1|A0AAA9TPV7_BOVIN Computationally mapped isoform of Zona pellucida binding protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9ST46-1" }, "locus": { "chromosome": "4", "start_pos": 5961325, "end_pos": 5813076, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104739.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104739.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100593.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100593.1" } ] } }, { "isoform_ac": "F1N369-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46/entry#F1N369-1", "sequence": { "sequence": "MGKPVSQVPPIYLIRFGYLDRLPRSAQLPQDSVKIVGSPNIPVKVYVMLHQKSPHVLCVTQRLRNSELVDPSFQWHGPKGKIISENSTAQITSTGSLVFQNFEESMSGVYTCFLEYKPTVEEVIKNLQLKYVVYAYREPHYYYQFTARYHAAPCNSIYNISFEKKLLQILSKLVLDLSCEVSLLKSECHRVKMQRAGLQNELFFTFSVSSLDTEKGPKPCADHSCESSKRLSKAKNLIERFFNQQVEVLGRRAEPLPEIYYIEGTLQMVWINRCFPGYGMNILKHPRCPECCVICSPGSYNSRDGIHCLQCNSSLVFGAKACL", "length": 323, "header": "tr|F1N369-1|F1N369_BOVIN Computationally mapped isoform of Zona pellucida binding protein OS=Bos taurus OX=9913 GN=ZPBP PE=3 SV=4 CANONICAL=A0AAA9ST46-1" }, "locus": { "chromosome": "4", "start_pos": 5961325, "end_pos": 5810109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007229.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007229.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007229.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007229.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ], "pmid": "" }, { "name": "zona pellucida receptor complex", "id": "GO:0002199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002199", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST46" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 155, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 186, "end_pos": 188 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUH9-1", "uniprot_ac": "A0AAA9SUH9", "uniprot_id": "A0AAA9SUH9_BOVIN", "mass": { "chemical_mass": 181143.0, "monoisotopic_mass": 181143.0 }, "refseq": { "ac": "XP_024840808", "name": "collagen alpha-1(XI) chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840808" }, "gene_names": [ { "name": "COL11A1", "type": "recommended", "evidence": [ { "id": "A0AAA9SUH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ] }, { "name": "COL11A1", "type": "synonym", "evidence": [ { "id": "XP_024840808", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840808" } ] } ], "protein_names": [ { "name": "Collagen type XI alpha 1 chain", "type": "synonym", "evidence": [ { "id": "A0AAA9SUH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#names_and_taxonomy" } ] }, { "name": "collagen alpha-1(XI) chain precursor", "type": "synonym", "evidence": [ { "id": "XP_024840808", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840808" } ] }, { "name": "collagen alpha-1(XI) chain", "type": "synonym", "evidence": [ { "id": "XP_024840808", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840808" } ] }, { "name": "collagen, type XI, alpha 1", "type": "synonym", "evidence": [ { "id": "XP_024840808", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840808" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL11A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9", "locus": { "chromosome": "3", "start_pos": 40530663, "end_pos": 40305057, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021217", "url": "https://www.ensembl.org/id/ENSBTAG00000021217" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021217", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021217", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "287013", "url": "https://www.ncbi.nlm.nih.gov/gene/287013", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:287013", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:287013", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGNMQGP", "url": "https://omabrowser.org/oma/group/KGNMQGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0K0", "url": "https://www.orthodb.org/?gene=F1N0K0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1095", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1095", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2022090", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3000171", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000171", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8874081", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8874081", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024840808", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840808", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Z4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0K0", "url": "https://www.uniprot.org/uniprotkb/F1N0K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0K0-1", "url": "https://www.uniprot.org/uniprotkb/F1N0K0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEYAPEDIMEYDYEYGEAEYKEAESVTETPTVTEETIAQTEANIVDDFQEYNYGTESYQTEAPRSVSGSNEPNPVEEVFTEEYLTGEDYDSQRKNSEDMLYENKQIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPTNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGSLGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPPGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGVSGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGTGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPQGPKGTKGSTGPAGQKGDSGLPGPPGPPGPPGEVIQPLPILSPKKTRRHAESTQADAGDNILDYNDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDIEGNSINMVQMTFLKLLTASARQNFTYYCHQSVAWYDMSSGSYDKALRFLGSNDEEMSYDNNPYIKALFDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1805, "header": "tr|A0AAA9SUH9-1|A0AAA9SUH9_BOVIN Isoform 1 of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=1 CANONICAL=A0AAA9SUH9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZ18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#A0AAA9RZ18-1", "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEYAPEDIMEYDYEYGEAEYKEAESVTETPTVTEETIAQTEANIVDDFQEYNYGTESYQTEAPRSVSGSNEPNPVEEVFTEEYLTGEDYDSQRKNSEDMLYENKQIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPTNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGSLGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPPGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGVSGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGTGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPQGPKGTKGSTGPAGQKGDSGLPGPPGPPGPPGEVIQPLPILSPKKTRRHAESTQADAGDNILDYNDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDIEGNSINMVQMTFLKLLTASARQNFTYYCHQSVAWYDMSSGSYDKALRFLGSNDEEMSYDNNPYIKALFDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1787, "header": "tr|A0AAA9RZ18-1|A0AAA9SUH9_BOVIN Computationally mapped isoform of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=1 CANONICAL=A0AAA9SUH9-1" }, "locus": { "chromosome": "3", "start_pos": 40529100, "end_pos": 40305371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104484.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104484.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077869.1" } ] } }, { "isoform_ac": "A0AAA9S1S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#A0AAA9S1S8-1", "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEYAPEDIMEYDYEYGEAEYKEAESVTETPTVTEETIAQTEKKKFSFKMKMKTVATNSKKKSKKFTPPKSEKFASKKKKTYQAAAMAKLGVKANIVDDFQEYNYGTESYQTEAPRSVSGSNEPNPVEEVFTEEYLTGEDYDSQRKNSEDMLYENKQIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPTNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKICHNHIFKIFISPQKE", "length": 780, "header": "tr|A0AAA9S1S8-1|A0AAA9SUH9_BOVIN Computationally mapped isoform of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=1 CANONICAL=A0AAA9SUH9-1" }, "locus": { "chromosome": "3", "start_pos": 40405538, "end_pos": 40305371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103450.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103450.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078980.1" } ] } }, { "isoform_ac": "A0AAA9SD09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#A0AAA9SD09-1", "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEANIVDDFQEYNYGTESYQTEAPRSVSGSNEPNPVEEVFTEEYLTGEDYDSQRKNSEDMLYENKQIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPTNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGSLGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPPGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGVSGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGTGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPQGPKGTKGSTGPAGQKGDSGLPGPPGPPGPPGEVIQPLPILSPKKTRRHAESTQADAGDNILDYNDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDIEGNSINMVQMTFLKLLTASARQNFTYYCHQSVAWYDMSSGSYDKALRFLGSNDEEMSYDNNPYIKALFDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1766, "header": "tr|A0AAA9SD09-1|A0AAA9SUH9_BOVIN Computationally mapped isoform of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=1 CANONICAL=A0AAA9SUH9-1" }, "locus": { "chromosome": "3", "start_pos": 40529100, "end_pos": 40305371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081407.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081407.1" } ] } }, { "isoform_ac": "A0AAA9SUH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#A0AAA9SUH9-1", "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEYAPEDIMEYDYEYGEAEYKEAESVTETPTVTEETIAQTEANIVDDFQEYNYGTESYQTEAPRSVSGSNEPNPVEEVFTEEYLTGEDYDSQRKNSEDMLYENKQIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPTNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGSLGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPPGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGVSGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGTGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPQGPKGTKGSTGPAGQKGDSGLPGPPGPPGPPGEVIQPLPILSPKKTRRHAESTQADAGDNILDYNDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDIEGNSINMVQMTFLKLLTASARQNFTYYCHQSVAWYDMSSGSYDKALRFLGSNDEEMSYDNNPYIKALFDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1805, "header": "tr|A0AAA9SUH9-1|A0AAA9SUH9_BOVIN Isoform 1 of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=1 CANONICAL=A0AAA9SUH9-1" }, "locus": { "chromosome": "3", "start_pos": 40529100, "end_pos": 40305371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134409.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134409.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086795.1" } ] } }, { "isoform_ac": "A0AAA9T2Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#A0AAA9T2Z4-1", "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEYAPEDIMEYDYEYGEAEYKEAESVTETPTVTEETIAQTEINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGSLGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPPGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGVSGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGTGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPQGPKGTKGSTGPAGQKGDSGLPGPPGPPGPPGEVIQPLPILSPKKTRRHAESTQADAGDNILDYNDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDIEGNSINMVQMTFLKLLTASARQNFTYYCHQSVAWYDMSSGSYDKALRFLGSNDEEMSYDNNPYIKALFDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1690, "header": "tr|A0AAA9T2Z4-1|A0AAA9T2Z4_BOVIN Computationally mapped isoform of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=1 CANONICAL=A0AAA9SUH9-1" }, "locus": { "chromosome": "3", "start_pos": 40529100, "end_pos": 40305371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122513.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122513.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090850.1" } ] } }, { "isoform_ac": "F1N0K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9/entry#F1N0K0-1", "sequence": { "sequence": "MERWSSRWKTKRWLWDFTITTLALTFLFQAREVRGADPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFSGGTFPEDFSILFTIKPQKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLYEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSEKAIVDTNGIMVFGTRILDEEVFEGDIQQLLIIGDPKAAYDYCEHYSPDCDSSAPEAAQAQEPQVDEKKKFSFKMKMKTVATNSKKKSKKFTPPKSEKFASKKKKTYQAAAMAKLGVKANIVDDFQEYNYGTESYQTEAPRSVSGSNEPNPVEEVFTEEYLTGEDYDSQRKNSEDMLYENKQIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPTNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLIEGPPGPAGPAGLMGPPGLQGPTGPPGDPGERGPPGRPGLPGADGLPGPPGTMLVLPFRYGGDSSKGPTVSAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGEMGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGEDGIRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPIGQPGIAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGSLGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPPGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGVSGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGTGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPQGPKGTKGSTGPAGQKGDSGLPGPPGPPGPPGEVIQPLPILSPKKTRRHAESTQADAGDNILDYNDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDIEGNSINMVQMTFLKLLTASARQNFTYYCHQSVAWYDMSSGSYDKALRFLGSNDEEMSYDNNPYIKALFDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1817, "header": "tr|F1N0K0-1|F1N0K0_BOVIN Computationally mapped isoform of Collagen type XI alpha 1 chain OS=Bos taurus OX=9913 GN=COL11A1 PE=4 SV=3 CANONICAL=A0AAA9SUH9-1" }, "locus": { "chromosome": "3", "start_pos": 40529100, "end_pos": 40305371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028276.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028276.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028276.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028276.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 507, "start_aa": "Thr", "end_pos": 507, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr507", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 658, "start_aa": "Thr", "end_pos": 658, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr658", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 821, "start_aa": "Thr", "end_pos": 821, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr821", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:287013", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:287013", "resource": "KEGG Pathway" }, { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-2022090", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "resource": "Reactome", "description": "Assembly of collagen fibrils and other multimeric structures" }, { "id": "R-BTA-3000171", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000171", "resource": "Reactome", "description": "Non-integrin membrane-ECM interactions" }, { "id": "R-BTA-8874081", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8874081", "resource": "Reactome", "description": "MET activates PTK2 signaling" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [ { "uniprot_canonical_ac": "P12107-1", "protein_name": "Collagen alpha-1(XI) chain", "gene_name": "COL11A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEANIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG", "length": 1806 }, "evidence": [ { "id": "A0AAA9SUH9", "url": "https://omabrowser.org/oma/group/A0AAA9SUH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P20909-1", "protein_name": "Collagen alpha-1(XI) chain", "gene_name": "Col11a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPWSRWKTKRWIWDLTISTLVLTFLFQAREVRGAAPVDILKALDFHNSPVGISKTTGFCTSRKNSKDPDIAYRVTEEAQISAPTKQLFPGGIFPQDFSILFTIKPKKGTQAFLLSLYNEHGIQQLGVEVGRSPVFLFEDHTGKPTPENYPLFSTVNIADGKWHRVAISVEKKTVTMIVDCKKKITKPLDRSERSIVDTNGIMVFGTRILETDVFQGDIQQFLITGDPKAAYDYCDHYSPDCDLTSKAAQAQEPHIDEYAPEDIIEYDYEYGETDYKEAESVTEMPTVTEETVAQTEANIVDDFQDYNYGTMETYQTESPRRVSGSNEPNPVEEGFTEEYLTGEDYDVQRNISEDILYGNKGIDGRDSDLLVDGDLGEYDFYEYKEYEERTTTSPNEEFGPGVPAETDFTETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGLMGPPGLQGPSGLPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSAGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGSKGDRGFDGLPGLPGDKGHRGERGPQGPPGLPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPPGQPGIGGIDGPQGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGIAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPAGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGTPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGIRGFPGERGLPGAQGAPGLKGGEGPQGPQGPIGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEAGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGGVGEKGEPGEAGNPGPPGEAGSGGPKGERGEKGEAGPPGAAGPPGIKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGASGSEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPSGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPAGPKGNKGSSGPTGQKGDSGMPGPPGPPGPPGEVIQPLPILSPKKTRRHTESIQADAGDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTAGGETCIYPDKKSEGVRLSSWPKEKPGSWYSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYNCHQSTAWYDVLSGSYDKALRFLGSNDEEMSYENNPHIKALYDGCASRKGYEKTVIEINTPKIDQVPIIDVMINDFGDQNQKFGFEVGPACFLG", "length": 1804 }, "evidence": [ { "id": "A0AAA9SUH9", "url": "https://omabrowser.org/oma/group/A0AAA9SUH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61245-1", "protein_name": "Collagen alpha-1(XI) chain", "gene_name": "Col11a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPWSRWKTKRWIWDLTISTLALTFLFQAREVRGAAPVDILKALDFHNSPVGISKTTGFCTNRKNSKDPDVAYRVTEEAQISAPTKQLFPGGIFPQDFSILFTIKPKKGTQAFLLSLYNEHGIQQLGVEVGRSPVFLFEDHTGKPTPENYPLFSTVNIADGKWHRVAISVEKKTVTMIVDCKKKITKPLDRSERSIVDTNGIMVFGTRILETDVFQGDIQQFLITGDPKAAYDYCDHYSPDCDLTSKAAQAQEPHIDEYAPEDIIEYDYEYGETDYKEAESVTEMPTFTEETVAQTEANIVDDFQDYNYGTMEPYQTETPRRVSGSNEPNPVEEGFTEEYLTGEDYDVQRNTSEDILYGNKGVDGRDSDLLVDGDLGEYDFYEYKEYEERTTTSPNEEFGPGVPAETDFTETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGLMGPPGLQGPSGLPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSAGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGESGSKGDRGFDGLPGLPGDKGHRGERGPQGPPGLPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPPGQPGIGGIDGPQGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGIAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPAGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGIRGFPGERGLPGAQGAPGLKGGEGPQGPQGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGLPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGVVGDKGEPGEAGNPGPPGEAGSGGLKGERGEKGEAGPPGAAGPAGIKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGASGSEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPSGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPAGPKGNKGSSGPTGQKGDSGMPGPPGPPGPPGEVIQPLPILSPKKTRRHTESIQGDAGDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTAGGETCIYPDKKSEGVRISSWPKEKPGSWYSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYNCHQSAAWYDVLSGSYDKALRFLGSNDEEMSYENNPHIKALYDGCASRKGYEKTVIEINTPKIDQVPIIDVMINDFGDQNQKFGFEVGPACFLG", "length": 1804 }, "evidence": [ { "id": "A0AAA9SUH9", "url": "https://omabrowser.org/oma/group/A0AAA9SUH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent conferring tensile strength", "id": "GO:0030020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "collagen type XI trimer", "id": "GO:0005592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005592", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "collagen type II trimer", "id": "GO:0005585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005585", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "detection of mechanical stimulus involved in sensory perception of sound", "id": "GO:0050910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050910", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "skeletal system morphogenesis", "id": "GO:0048705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048705", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" }, { "name": "endodermal cell differentiation", "id": "GO:0035987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035987", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1639, "end_pos": 1641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1708, "end_pos": 1710, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH9" }, { "id": "PS51461", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51461" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrillar collagen NC1", "eco_id": "ECO_0000259", "start_pos": 1576, "end_pos": 1804, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 507, 658, 821 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1639, "end_pos": 1641 }, { "start_pos": 1708, "end_pos": 1710 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1668 }, { "field": "total_sites", "count": 1120 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1642 }, { "field": "total_sites", "count": 1106 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 26 }, { "field": "total_sites", "count": 19 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 130 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9STY1-1", "uniprot_ac": "A0AAA9STY1", "uniprot_id": "A0AAA9STY1_BOVIN", "mass": { "chemical_mass": 78799.0, "monoisotopic_mass": 78799.0 }, "refseq": { "ac": "XP_059746985", "name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746985" }, "gene_names": [ { "name": "GFPT1", "type": "recommended", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ] }, { "name": "GFPT1", "type": "synonym", "evidence": [ { "id": "XP_059746985", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746985" } ] } ], "protein_names": [ { "name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "type": "recommended", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.16", "type": "synonym", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#names_and_taxonomy" } ] }, { "name": "D-fructose-6-phosphate amidotransferase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#names_and_taxonomy" } ] }, { "name": "Glutamine:fructose-6-phosphate amidotransferase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#names_and_taxonomy" } ] }, { "name": "Hexosephosphate aminotransferase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#names_and_taxonomy" } ] }, { "name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059746985", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746985" } ] } ], "function": [ { "annotation": "Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway. Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop. Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling. Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation.", "evidence": [ { "database": "UniProtKB", "id": "F1MZY2", "url": "https://www.uniprot.org/uniprotkb/F1MZY2#function" }, { "database": "UniProtKB", "id": "ARBA00094502", "url": "https://www.uniprot.org/uniprotkb/ARBA00094502#function" }, { "database": "UniProtKB", "id": "A0AAA9SQI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI1#function" }, { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GFPT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1", "locus": { "chromosome": "11", "start_pos": 67708302, "end_pos": 67766635, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017626", "url": "https://www.ensembl.org/id/ENSBTAG00000017626" } ] } } ], "crossref": [ { "id": "A0AAA9STY1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017626", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017626", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00714", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00714", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05008", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05008", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281779", "url": "https://www.ncbi.nlm.nih.gov/gene/281779", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ASEYRYA", "url": "https://omabrowser.org/oma/group/ASEYRYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10937:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10937:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01380", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01380", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-446210", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446210", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059746985", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746985", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13237", "url": "https://www.rhea-db.org/rhea/13237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZY2", "url": "https://www.uniprot.org/uniprotkb/F1MZY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZY2-1", "url": "https://www.uniprot.org/uniprotkb/F1MZY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGIDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 699, "header": "tr|A0AAA9STY1-1|A0AAA9STY1_BOVIN Isoform 1 of Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Bos taurus OX=9913 GN=GFPT1 PE=1 SV=1 CANONICAL=A0AAA9STY1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#A0AAA9RZK4-1", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGIDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 625, "header": "tr|A0AAA9RZK4-1|A0AAA9STY1_BOVIN Computationally mapped isoform of Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Bos taurus OX=9913 GN=GFPT1 PE=1 SV=1 CANONICAL=A0AAA9STY1-1" }, "locus": { "chromosome": "11", "start_pos": 67766565, "end_pos": 67708415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125901.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125901.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076774.1" } ] } }, { "isoform_ac": "A0AAA9SQI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#A0AAA9SQI1-1", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGIDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 649, "header": "tr|A0AAA9SQI1-1|A0AAA9STY1_BOVIN Computationally mapped isoform of Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Bos taurus OX=9913 GN=GFPT1 PE=1 SV=1 CANONICAL=A0AAA9STY1-1" }, "locus": { "chromosome": "11", "start_pos": 67766565, "end_pos": 67708415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132390.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132390.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086190.1" } ] } }, { "isoform_ac": "A0AAA9STY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#A0AAA9STY1-1", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGIDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 699, "header": "tr|A0AAA9STY1-1|A0AAA9STY1_BOVIN Isoform 1 of Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Bos taurus OX=9913 GN=GFPT1 PE=1 SV=1 CANONICAL=A0AAA9STY1-1" }, "locus": { "chromosome": "11", "start_pos": 67766565, "end_pos": 67708415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119673.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119673.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089880.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089880.1" } ] } }, { "isoform_ac": "A0AAA9TVD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#A0AAA9TVD5-1", "sequence": { "sequence": "MCEQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 609, "header": "tr|A0AAA9TVD5-1|A0AAA9TVD5_BOVIN Computationally mapped isoform of glutamine--fructose-6-phosphate transaminase (isomerizing) OS=Bos taurus OX=9913 GN=GFPT1 PE=1 SV=1 CANONICAL=A0AAA9STY1-1" }, "locus": { "chromosome": "11", "start_pos": 67766565, "end_pos": 67708415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088378.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088378.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102326.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102326.1" } ] } }, { "isoform_ac": "F1MZY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1/entry#F1MZY2-1", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGIDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 681, "header": "tr|F1MZY2-1|F1MZY2_BOVIN Computationally mapped isoform of Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Bos taurus OX=9913 GN=GFPT1 PE=1 SV=2 CANONICAL=A0AAA9STY1-1" }, "locus": { "chromosome": "11", "start_pos": 67766565, "end_pos": 67708415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023441.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023441.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023441.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023441.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-446210", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446210", "resource": "Reactome", "description": "Synthesis of UDP-N-acetyl-glucosamine" } ], "orthologs": [ { "uniprot_canonical_ac": "P14742-1", "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing]", "gene_name": "GFA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE", "length": 717 }, "evidence": [ { "id": "A0AAA9STY1", "url": "https://omabrowser.org/oma/group/A0AAA9STY1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P47856-1", "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "gene_name": "Gfpt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSTWWGSQAERGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 697 }, "evidence": [ { "id": "A0AAA9STY1", "url": "https://omabrowser.org/oma/group/A0AAA9STY1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P82808-1", "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "gene_name": "Gfpt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGMATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 681 }, "evidence": [ { "id": "A0AAA9STY1", "url": "https://omabrowser.org/oma/group/A0AAA9STY1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q06210-1", "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "gene_name": "GFPT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRWGSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE", "length": 699 }, "evidence": [ { "id": "A0AAA9STY1", "url": "https://omabrowser.org/oma/group/A0AAA9STY1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54LK1-1", "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing]", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNQNTIRRLQVTQRHLLEQQQEQQQYQHNSSDSFDGLESSDTCGIIGFVGKEEAINYLLEGLAILENRGYDSAGVTTISSDNDLVTSKYASLNTTSDAITRLKSVAHLHKGHVIGIAHTRWATHGGKTDKNAHPHLDYKDRVAVIHNGVIENNIILKEELEKKGIVFRSETDTEVIAQLIGLFLDQGLQIVDAIKETQKKLQGTWGIAVVCKDNPDQIVAARNGSPLLIGIGKDRMFIASEPGAFSRHTKEFISMENGEIAVLKADGHSLDLSRIEMAAHETIALSPEPYPHWTIKEIMEQPMSISRALNYGGRISDESRVKLGGLEDAKDLLLPIKNLIITGCGTSFFAAQFGARIMRYLGAFDTVQVFDAAEIIRDTLPHNHAGVLMISQSGETKDVARILTLAEESGIPRFSIVNAVGSLIARSSICGVYLNAGREHAVASTKAFSSQVTVLSLVANWFAQHRGIEEGKRRQLIDSLHRLPTNLGMALRVREQCKAIAQKIYKKNSIFVLGKGFAEPIAFEGALKIKEITYCHAEGYSGGALKHGPFALIEQDTPIILIILDDSNSPLMRVAAEEVKARGAHTIVITNNSTLAKHIAHDTILIPSNGILTALLAAIPLQLLAYEMAICKNIDPDRPKNLAKTVTTD", "length": 649 }, "evidence": [ { "id": "A0AAA9STY1", "url": "https://omabrowser.org/oma/group/A0AAA9STY1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7PLC7-1", "protein_name": "glutamine--fructose-6-phosphate transaminase (isomerizing)", "gene_name": "Gfat1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCGIFAYLNYLTPKSRQEVLDLLVTGLKRLEYRGYDSTGVAIDSPDNKNIVMVKRTGKVKVLEEAIQEHFSGREYSEPVLTHVGIAHTRWATHGVPCEKNSHPHRSDDENGFVVVHNGIITNYNDVKTFLSKRGYEFESDTDTEVFAKLVHHLWKTHPTYSFRELVEQAILQVEGAFAIAVKSKYFPGECVASRRSSPLLVGIKTKTRLATDHIPILYGKDDKKLCTDQDADSGKPQDIRPHGQSRELPVLPRSESTSEFMPLEEKEVEYFFASDASAVIEHTNRVIYLEDDDVAAVRDGTLSIHRLKKSLDDPHAREITTLKMEIQQIMKGNYDYFMQKEIFEQPDSVVNTMRGRVRFDGNAIVLGGIKDYIPEIKRCRRLMLIGCGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPIFRDDVCFFISQSGETADTLMALRYCKQRGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQQRRLEILQALSKLADQIRDVLQLDSKVKELAKDLYQHKSLLIMGRGYNFATCLEGALKVKELTYMHSEGIMAGELKHGPLALVDDSMPVLMIVLRDPVYVKCMNALQQVTSRKGCPIIICEEGDEETKAFSSRHLEIPRTVDCLQGILTVIPMQLLSYHIAVLRGCDVDCPRNLAKSVTVE", "length": 694 }, "evidence": [ { "id": "A0AAA9STY1", "url": "https://omabrowser.org/oma/group/A0AAA9STY1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glutamine-fructose-6-phosphate transaminase (isomerizing) activity", "id": "GO:0004360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "carbohydrate derivative binding", "id": "GO:0097367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097367", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "carbohydrate derivative metabolic process", "id": "GO:1901135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901135", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine biosynthetic process", "id": "GO:0006048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006048", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "circadian regulation of gene expression", "id": "GO:0032922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "fructose 6-phosphate metabolic process", "id": "GO:0006002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006002", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "carbohydrate derivative biosynthetic process", "id": "GO:1901137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901137", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine metabolic process", "id": "GO:0006047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13237", "name": "", "equation": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9STY1-1", "Q08DQ2-1" ], "evidence": [ { "id": "13237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13237" } ] }, { "id": "R-BTA-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DQ2-1", "A0AAA9STY1-1" ], "evidence": [ { "id": "R-BTA-449715", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-449715" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9STY1", "gene_name": "GFPT1", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" } ] } ] }, { "uniprot_ac": "Q08DQ2", "gene_name": "GFPT2", "activity": [ { "ec_number": "2.6.1.16", "activity": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "Q08DQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DQ2" } ] }, { "ec_number": "2.6.1.16", "activity": "", "evidence": [ { "id": "Q08DQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DQ2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" }, { "id": "PS51278", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51278" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glutamine amidotransferase type-2", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 305, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9STY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY1" }, { "id": "PS51464", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51464" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SIS", "eco_id": "ECO_0000259", "start_pos": 377, "end_pos": 516, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.6.1.16", "ec_name": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.", "evidence": [ { "id": "2.6.1.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.16" }, { "id": "2.6.1.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.16" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 255, "end_pos": 257 }, { "start_pos": 338, "end_pos": 340 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STA8-1", "uniprot_ac": "A0AAA9STA8", "uniprot_id": "A0AAA9STA8_BOVIN", "mass": { "chemical_mass": 74929.0, "monoisotopic_mass": 74929.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112445770", "type": "recommended", "evidence": [ { "id": "A0AAA9STA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8" } ] } ], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112445770", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8", "locus": {} } ], "crossref": [ { "id": "A0AAA9STA8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "112445770", "url": "https://www.ncbi.nlm.nih.gov/gene/112445770", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112445770", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445770", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S3L8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3L8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E6D1", "url": "https://www.uniprot.org/uniprotkb/G5E6D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E6D1-1", "url": "https://www.uniprot.org/uniprotkb/G5E6D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPTQMCPNLLSLGRDSCLWSLTTAIMPRGQKSKHRAREKRRQARAETQGVHDQATTSRGEETTSSSPPDSESAPSSSSAAGTSKGPPGAQGTTSAAEGAIRKRSRGGGAARSRSGVGGAARSRSGVGAEGQVQEGENSSQASAAAASSHTDLLTMKAELLVQYMLYKYKMREFIKRSKMLQKINRRYKEQFPEILSKASEHMEMVFGLVLKEVRPNSHCYTLVSNLDLSDSESMRGDLGLPKNGLLMPLLGVIYLNGNHAPEEKIWKFLNMLGIYDGRSHFIFGEPRKLITEDLVREEYLEYHQVPGSDPPRYEFLCGPKALTETSKTKILQFLAKVKDSVHPALQPQYEEAWREEIESTGARSEARAGTSASTRPGTAASAAAGRSASTRPGTAALATAGRSTSARPGTGVSASFGHSASTRPGTAASAAAGRSASTRPGTAALAAAGHSASARPGTAASASTGHSSSSRPGTSALATAGTSALATAGTSASTRPGTAASAIAGTSASSSPGTAASASAGRSASARPGTAASATAGTSASTSPGTAASASAGPSASARPGTAASATAGTSASTSPGTAASASAGRSASPGLALLPQPLLALLPQPGLALLPQPLLALLPHPALALLPQPVLAVLLRPGLALLPQPLLALLPQPGLALLPQPLLAVVPQPGLALLLQPLLALVPRPGLALLPQPLLALLPQPGLALLPQPLLALLLQPLCTPGPHPAAYLVPSVI", "length": 737, "header": "tr|A0AAA9STA8-1|A0AAA9STA8_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC112445770 PE=4 SV=1 CANONICAL=A0AAA9STA8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8/entry#A0AAA9S3L8-1", "sequence": { "sequence": "MPRGQKSKHRAREKRRQARAETQGVHDQATTSRGEETTSSSPPDSESAPSSSSAAGTSKGPPGAQGTTSAAEGAIRKRSRGGGAARSRSGVGGAARSRSGVGAEGQVQEGENSSQASAAAASSHTDLLTMKAELLVQYMLYKYKMREFIKRSKMLQKINRRYKEQFPEILSKASEHMEMVFGLVLKEVRPNSHCYTLVSNLDLSDSESMRGDLGLPKNGLLMPLLGVIYLNGNHAPEEKIWKFLNMLGIYDGRSHFIFGEPRKLITEDLVREEYLEYHQVPGSDPPRYEFLCGPKALTETSKTKILQFLAKVKDSVHPALQPQYEEAWREEIESTGARSEARAGTSASTRPGTAASAAAGRSASTRPGTAALATAGRSTSARPGTGVSASFGHSASTRPGTAASAAAGRSASTRPGTAALAAAGHSASARPGTAASASTGHSSSSRPGTSALATAGTSALATAGTSASTRPGTAASAIAGTSASSSPGTAASASAGRSASARPGTAASATAGTSASTSPGTAASASAGPSASARPGTAASATAGTSASTSPGTAASASAGRSASPGLALLPQPLLALLPQPGLALLPQPLLALLPHPALALLPQPVLAVLLRPGLALLPQPLLALLPQPGLALLPQPLLAVVPQPGLALLLQPLLALVPRPGLALLPQPLLALLPQPGLALLPQPLLALLLQPLCTPGPHPAAYLVPSVI", "length": 710, "header": "tr|A0AAA9S3L8-1|A0AAA9STA8_BOVIN Computationally mapped isoform of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC112445770 PE=4 SV=1 CANONICAL=A0AAA9STA8-1" }, "locus": { "chromosome": "NKLS02002047.1", "start_pos": 7010, "end_pos": 4881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114348.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114348.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077859.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077859.1" } ] } }, { "isoform_ac": "A0AAA9STA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8/entry#A0AAA9STA8-1", "sequence": { "sequence": "MASPTQMCPNLLSLGRDSCLWSLTTAIMPRGQKSKHRAREKRRQARAETQGVHDQATTSRGEETTSSSPPDSESAPSSSSAAGTSKGPPGAQGTTSAAEGAIRKRSRGGGAARSRSGVGGAARSRSGVGAEGQVQEGENSSQASAAAASSHTDLLTMKAELLVQYMLYKYKMREFIKRSKMLQKINRRYKEQFPEILSKASEHMEMVFGLVLKEVRPNSHCYTLVSNLDLSDSESMRGDLGLPKNGLLMPLLGVIYLNGNHAPEEKIWKFLNMLGIYDGRSHFIFGEPRKLITEDLVREEYLEYHQVPGSDPPRYEFLCGPKALTETSKTKILQFLAKVKDSVHPALQPQYEEAWREEIESTGARSEARAGTSASTRPGTAASAAAGRSASTRPGTAALATAGRSTSARPGTGVSASFGHSASTRPGTAASAAAGRSASTRPGTAALAAAGHSASARPGTAASASTGHSSSSRPGTSALATAGTSALATAGTSASTRPGTAASAIAGTSASSSPGTAASASAGRSASARPGTAASATAGTSASTSPGTAASASAGPSASARPGTAASATAGTSASTSPGTAASASAGRSASPGLALLPQPLLALLPQPGLALLPQPLLALLPHPALALLPQPVLAVLLRPGLALLPQPLLALLPQPGLALLPQPLLAVVPQPGLALLLQPLLALVPRPGLALLPQPLLALLPQPGLALLPQPLLALLLQPLCTPGPHPAAYLVPSVI", "length": 737, "header": "tr|A0AAA9STA8-1|A0AAA9STA8_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC112445770 PE=4 SV=1 CANONICAL=A0AAA9STA8-1" }, "locus": { "chromosome": "NKLS02002047.1", "start_pos": 16021, "end_pos": 4881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129768.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129768.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086290.1" } ] } }, { "isoform_ac": "G5E6D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8/entry#G5E6D1-1", "sequence": { "sequence": "MPRGQKSKHRAREKRRQARAETQGVHDQATTSRGEETTSSSPPDSESAPSSSSAAGTSKGPPGAQGTTSAAEGAIRKRSRGGGAARSRSGVGAEGQVQEGENSSQASAAAASSHTDLLTMKAELLVQYMLYKYKMREFIKRSKMLQKINRRYKEQFPEILSKASEHMEMVFGLVLKEVRPNSHCYTLVSNLDLSDSESMRGDLGLPKNGLLMPLLGVIYLNGNHAPEEKIWKFLNMLGIYDGRSHFIFGEPRKLITEDLVREEYLEYHQVPGSDPPRYEFLCGPKALTETSKTKILQFLAKVKDSVHPALQPQYEEAWREEIESTGARSEARAGTSASTRPGTAASAAAGRSA", "length": 353, "header": "tr|G5E6D1-1|G5E6D1_BOVIN Computationally mapped isoform of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC112445770 PE=4 SV=3 CANONICAL=A0AAA9STA8-1" }, "locus": { "chromosome": "NKLS02002047.1", "start_pos": 7010, "end_pos": 5922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057223.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057223.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050875.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050875.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112445770", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112445770", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA8" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 354, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 139, "end_pos": 141 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSU5-1", "uniprot_ac": "A0AAA9SSU5", "uniprot_id": "A0AAA9SSU5_BOVIN", "mass": { "chemical_mass": 54645.0, "monoisotopic_mass": 54645.0 }, "refseq": {}, "gene_names": [ { "name": "KCNG2", "type": "recommended", "evidence": [ { "id": "A0AAA9SSU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel modifier subfamily G member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, can modulate the kinetics and conductance-voltage relationship. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Potassium channel subunit that does not form functional channels by itself.", "evidence": [ { "database": "UniProtKB", "id": "F1MJA9", "url": "https://www.uniprot.org/uniprotkb/F1MJA9#function" }, { "database": "UniProtKB", "id": "ARBA00058183", "url": "https://www.uniprot.org/uniprotkb/ARBA00058183#function" }, { "database": "UniProtKB", "id": "A0AAA9S462", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S462#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5", "locus": { "chromosome": "24", "start_pos": 613545, "end_pos": 666341, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013665", "url": "https://www.ensembl.org/id/ENSBTAG00000013665" } ] } } ], "crossref": [ { "id": "A0AAA9SSU5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013665", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013665", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506324", "url": "https://www.ncbi.nlm.nih.gov/gene/506324", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506324", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506324", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MJA9", "url": "https://www.orthodb.org/?gene=F1MJA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381676", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S462", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S462", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S462-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S462-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJA9", "url": "https://www.uniprot.org/uniprotkb/F1MJA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJA9-1", "url": "https://www.uniprot.org/uniprotkb/F1MJA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLPGPAERRGGGGGARARHVIINVGGCRVRLAWAALARCPLARLERLRTCRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARAGPAERGAPGSPACTPRPGGRLARGRRRLRDVVDDPRSGPAGKLFACVSVAFVAVTAVGLCLSTMPDIRAEEERCHLRFLMERQGVRCLPAHQLQLPGGECSPKCRNLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLNIIDILAILPFYVSLLVGLAARPGAGGNKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPALREDSTRSASASATATEDDGSQSPDGAGSAGASAEGPWAPAGPT", "length": 501, "header": "tr|A0AAA9SSU5-1|A0AAA9SSU5_BOVIN Isoform 1 of Potassium voltage-gated channel modifier subfamily G member 2 OS=Bos taurus OX=9913 GN=KCNG2 PE=4 SV=1 CANONICAL=A0AAA9SSU5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S462-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5/entry#A0AAA9S462-1", "sequence": { "sequence": "MGPWPCCPGGGGGARARHVIINVGGCRVRLAWAALARCPLARLERLRTCRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARAGPAERGAPGSPACTPRPGGRLARGRRRLRDVVDDPRSGPAGKLFACVSVAFVAVTAVGLCLSTMPDIRAEEERGECSPKCRNLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLNIIDILAILPFYVSLLVGLAARPGAGGNKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPALREDSTRSASASATATEDDGSQSPDGAGSAGASAEGPWAPAGPT", "length": 474, "header": "tr|A0AAA9S462-1|A0AAA9SSU5_BOVIN Computationally mapped isoform of Potassium voltage-gated channel modifier subfamily G member 2 OS=Bos taurus OX=9913 GN=KCNG2 PE=4 SV=1 CANONICAL=A0AAA9SSU5-1" }, "locus": { "chromosome": "24", "start_pos": 636227, "end_pos": 614237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105066.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105066.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078058.1" } ] } }, { "isoform_ac": "A0AAA9SSU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5/entry#A0AAA9SSU5-1", "sequence": { "sequence": "MALLPGPAERRGGGGGARARHVIINVGGCRVRLAWAALARCPLARLERLRTCRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARAGPAERGAPGSPACTPRPGGRLARGRRRLRDVVDDPRSGPAGKLFACVSVAFVAVTAVGLCLSTMPDIRAEEERCHLRFLMERQGVRCLPAHQLQLPGGECSPKCRNLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLNIIDILAILPFYVSLLVGLAARPGAGGNKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPALREDSTRSASASATATEDDGSQSPDGAGSAGASAEGPWAPAGPT", "length": 501, "header": "tr|A0AAA9SSU5-1|A0AAA9SSU5_BOVIN Isoform 1 of Potassium voltage-gated channel modifier subfamily G member 2 OS=Bos taurus OX=9913 GN=KCNG2 PE=4 SV=1 CANONICAL=A0AAA9SSU5-1" }, "locus": { "chromosome": "24", "start_pos": 636219, "end_pos": 614237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100694.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100694.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087066.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087066.1" } ] } }, { "isoform_ac": "F1MJA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5/entry#F1MJA9-1", "sequence": { "sequence": "MALLPGPAERRGGGGGARARHVIINVGGCRVRLAWAALARCPLARLERLRTCRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAEARAGPAERGAPGSPACTPRPGGRLARGRRRLRDVVDDPRSGPAGKLFACVSVAFVAVTAVGLCLSTMPDIRAEEERGECSPKCRNLFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLNIIDILAILPFYVSLLVGLAARPGAGGNKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPALREDSTRSASASATATEDDGSQSPDGAGSAGASAEGPWAPAGPT", "length": 477, "header": "tr|F1MJA9-1|F1MJA9_BOVIN Computationally mapped isoform of Voltage-gated potassium channel regulatory subunit KCNG2 OS=Bos taurus OX=9913 GN=KCNG2 PE=3 SV=4 CANONICAL=A0AAA9SSU5-1" }, "locus": { "chromosome": "24", "start_pos": 636219, "end_pos": 614237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018162.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018162.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018162.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018162.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 501, "start_aa": "Thr", "end_pos": 501, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr501", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506324", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506324", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" }, { "id": "R-BTA-381676", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381676", "resource": "Reactome", "description": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" }, { "name": "potassium channel regulator activity", "id": "GO:0015459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU5" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 128, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 501 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWF4-1", "uniprot_ac": "A0AAA9SWF4", "uniprot_id": "A0AAA9SWF4_BOVIN", "mass": { "chemical_mass": 64457.0, "monoisotopic_mass": 64457.0 }, "refseq": {}, "gene_names": [ { "name": "FSCN3", "type": "recommended", "evidence": [ { "id": "A0AAA9SWF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ] } ], "protein_names": [ { "name": "Fascin actin-bundling protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SWF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FSCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4", "locus": { "chromosome": "4", "start_pos": 91833300, "end_pos": 91823069, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009365", "url": "https://www.ensembl.org/id/ENSBTAG00000009365" } ] } } ], "crossref": [ { "id": "A0AAA9SWF4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23354", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23354", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR008999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10551:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10551:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5J4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEVEWTPRQPRAEDLRVGLISWAGSYLTYEPFKNTVTATAKGLGRRQTWEILVSNEHETQAVVRLRSLQGLYLLCEADGSLCYGRPRTSHHGCFLIRFHRNGQWTLQCIISGRYLESDGEDVFCTSRVLSAYHMWTPRPALHVHVILFSPLNHCYARADPTMGRVWVDAPIPCLEECGFLLHFQDGCYHLETSAHTFLSHLDRLVSQPSTQTAFHMQVRPGGLVALSDGEGGMLYPQGTRLLLSLGSNPHGGEEWFILQRCPTWVSLTSKARKFLSVIYDVEVCAASEHISPMSLFQFECDNETPTLQLRSANGCYLAQRRHRAVMADGHPVECETFFRMHWNCGRILLQSPNGRFLGIAANGLLMASATVPGPNEEFGIRLANRSFLALRGRYGYVGTSSEHDLLQCNMDQPDCIHLLPCRQGIYHFQGWILLVNNILWHLSALGKVRPQLLYRASGQQLAHGAGTQWLLHAIRQKWYPVGRQRRHYQRVYLGILGQQDATYGNLNLPGETTTLNQTRTPESRSMRRISVTQLFLPSLAKHLFQATIHHKRPPPRPWCASDLRVEV", "length": 568, "header": "tr|A0AAA9SWF4-1|A0AAA9SWF4_BOVIN Isoform 1 of Fascin actin-bundling protein 3 OS=Bos taurus OX=9913 GN=FSCN3 PE=3 SV=1 CANONICAL=A0AAA9SWF4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4/entry#A0AAA9S5J4-1", "sequence": { "sequence": "MHTGHGDYSPLLCTTALFLPGKTPPTGNRKIRTWEILVSNEHETQAVVRLRSLQGLYLLCEADGSLCYGRPRTSHHGCFLIRFHRNGQWTLQCIISGRYLESDGEDVFCTSRVLSAYHMWTPRPALHVHVILFSPLNHCYARADPTMGRVWVDAPIPCLEECGFLLHFQDGCYHLETSAHTFLSHLDRLVSQPSTQTAFHMQVRPGGLVALSDGEGGMLYPQGTRLLLSLGSNPHGGEEWFILQRCPTWVSLTSKARKFLSVIYDVEVCAASEHISPMSLFQFECDNETPTLQLRSANGCYLAQRRHRAVMADGHPVECETFFRMHWNCGRILLQSPNGRFLGIAANGLLMASATVPGPNEEFGIRLANRSFLALRGRYGYVGTSSEHDLLQCNMDQPDCIHLLPCRQGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELQGSNLLTVLAPNGFYMRSDRSGTLLADSEDITKECIWEF", "length": 482, "header": "tr|A0AAA9S5J4-1|A0AAA9SWF4_BOVIN Computationally mapped isoform of Fascin actin-bundling protein 3 OS=Bos taurus OX=9913 GN=FSCN3 PE=3 SV=1 CANONICAL=A0AAA9SWF4-1" }, "locus": { "chromosome": "4", "start_pos": 91829713, "end_pos": 91823208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078538.1" } ] } }, { "isoform_ac": "A0AAA9SWF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4/entry#A0AAA9SWF4-1", "sequence": { "sequence": "MEEVEWTPRQPRAEDLRVGLISWAGSYLTYEPFKNTVTATAKGLGRRQTWEILVSNEHETQAVVRLRSLQGLYLLCEADGSLCYGRPRTSHHGCFLIRFHRNGQWTLQCIISGRYLESDGEDVFCTSRVLSAYHMWTPRPALHVHVILFSPLNHCYARADPTMGRVWVDAPIPCLEECGFLLHFQDGCYHLETSAHTFLSHLDRLVSQPSTQTAFHMQVRPGGLVALSDGEGGMLYPQGTRLLLSLGSNPHGGEEWFILQRCPTWVSLTSKARKFLSVIYDVEVCAASEHISPMSLFQFECDNETPTLQLRSANGCYLAQRRHRAVMADGHPVECETFFRMHWNCGRILLQSPNGRFLGIAANGLLMASATVPGPNEEFGIRLANRSFLALRGRYGYVGTSSEHDLLQCNMDQPDCIHLLPCRQGIYHFQGWILLVNNILWHLSALGKVRPQLLYRASGQQLAHGAGTQWLLHAIRQKWYPVGRQRRHYQRVYLGILGQQDATYGNLNLPGETTTLNQTRTPESRSMRRISVTQLFLPSLAKHLFQATIHHKRPPPRPWCASDLRVEV", "length": 568, "header": "tr|A0AAA9SWF4-1|A0AAA9SWF4_BOVIN Isoform 1 of Fascin actin-bundling protein 3 OS=Bos taurus OX=9913 GN=FSCN3 PE=3 SV=1 CANONICAL=A0AAA9SWF4-1" }, "locus": { "chromosome": "4", "start_pos": 91832296, "end_pos": 91824254, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133344.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133344.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088374.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088374.1" } ] } }, { "isoform_ac": "A0AAA9TAT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4/entry#A0AAA9TAT8-1", "sequence": { "sequence": "MACLSEVLLFSCCVGKVVLTWEILVSNEHETQAVVRLRSLQGLYLLCEADGSLCYGRPRTSHHGCFLIRFHRNGQWTLQCIISGRYLESDGEDVFCTSRVLSAYHMWTPRPALHVHVILFSPLNHCYARADPTMGRVWVDAPIPCLEECGFLLHFQDGCYHLETSAHTFLSHLDRLVSQPSTQTAFHMQVRPGGLVALSDGEGGMLYPQGTRLLLSLGSNPHGGEEWFILQRCPTWVSLTSKARKFLSVIYDVEVCAASEHISPMSLFQFECDNETPTLQLRSANGCYLAQRRHRAVMADGHPVECETFFRMHWNCGRILLQSPNGRFLGIAANGLLMASATVPGPNEEFGIRLANRSFLALRGRYGYVGTSSEHDLLQCNMDQPDCIHLLPCRQGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELQGSNLLTVLAPNGFYMRSDRSGTLLADSEDITKECIWEF", "length": 469, "header": "tr|A0AAA9TAT8-1|A0AAA9TAT8_BOVIN Computationally mapped isoform of Fascin OS=Bos taurus OX=9913 GN=FSCN3 PE=3 SV=1 CANONICAL=A0AAA9SWF4-1" }, "locus": { "chromosome": "4", "start_pos": 91829713, "end_pos": 91825002, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123793.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123793.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093122.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093122.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 517, "end_pos": 519, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWF4" }, { "id": "PF06268", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fascin-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 127, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 385, "end_pos": 387 }, { "start_pos": 517, "end_pos": 519 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUM5-1", "uniprot_ac": "A0AAA9SUM5", "uniprot_id": "A0AAA9SUM5_BOVIN", "mass": { "chemical_mass": 23194.0, "monoisotopic_mass": 23194.0 }, "refseq": {}, "gene_names": [ { "name": "SZRD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SUM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5" } ] } ], "protein_names": [ { "name": "SUZ RNA-binding domain-containing", "type": "recommended", "evidence": [ { "id": "A0AAA9SUM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SZRD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5", "locus": { "chromosome": "2", "start_pos": 135729181, "end_pos": 135759412, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009251", "url": "https://www.ensembl.org/id/ENSBTAG00000009251" } ] } } ], "crossref": [ { "id": "A0AAA9SUM5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "512452", "url": "https://www.ncbi.nlm.nih.gov/gene/512452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024771", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024771", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31796", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31796", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31796:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31796:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S7M3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7M3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTE1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZDD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZDD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKS2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKS2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPB5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPB5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4E2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4E2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4E2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHGPVQGENGRTHDPWTDSSGRCGAPSSCWQSTRPLQTALGALGCSRPAEAAGTAFHQGRRRQNPSSPLQAEFLLSPEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 212, "header": "tr|A0AAA9SUM5-1|A0AAA9SUM5_BOVIN Isoform 1 of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=2 CANONICAL=A0AAA9SUM5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7M3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0AAA9S7M3-1", "sequence": { "sequence": "MRRSLKAGRRRQTAGRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 133, "header": "tr|A0AAA9S7M3-1|A0AAA9SUM5_BOVIN Computationally mapped isoform of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=2 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135759365, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117644.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117644.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079286.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079286.2" } ] } }, { "isoform_ac": "A0AAA9SMI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0AAA9SMI5-1", "sequence": { "sequence": "RGPGDRGRTAESPGGSPSPVGASPGRTWKSGRRAWGRAARGSRCPGGERRWTVRYFALGAFVCLHKLCEDSLSQAGAASSTCRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 200, "header": "tr|A0AAA9SMI5-1|A0AAA9SUM5_BOVIN Computationally mapped isoform of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=1 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135758738, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103664.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103664.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085110.1" } ] } }, { "isoform_ac": "A0AAA9SUM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0AAA9SUM5-1", "sequence": { "sequence": "MHGPVQGENGRTHDPWTDSSGRCGAPSSCWQSTRPLQTALGALGCSRPAEAAGTAFHQGRRRQNPSSPLQAEFLLSPEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 212, "header": "tr|A0AAA9SUM5-1|A0AAA9SUM5_BOVIN Isoform 1 of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=2 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135746051, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098784.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098784.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086857.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086857.1" } ] } }, { "isoform_ac": "A0AAF6YTE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0AAF6YTE1-1", "sequence": { "sequence": "PFLSENFSVWSETGLLRLCLLFVSRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 142, "header": "tr|A0AAF6YTE1-1|A0AAF6YTE1_BOVIN Computationally mapped isoform of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=1 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135741452, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012189.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012189.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012189.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012189.5" } ] } }, { "isoform_ac": "A0AAF6ZDD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0AAF6ZDD7-1", "sequence": { "sequence": "PLPWARAPGGPGRVAAGRGGALREAAAVPAGSGDGPFDTLLWGLLFASTSCAKIVYPKLEQPVRLGSCLIWRFQSEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 210, "header": "tr|A0AAF6ZDD7-1|A0AAF6ZDD7_BOVIN Computationally mapped isoform of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=1 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135758689, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037763.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037763.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037586.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037586.4" } ] } }, { "isoform_ac": "A0ABI0NKS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0ABI0NKS2-1", "sequence": { "sequence": "MKGLDHHLTLTQEIDRRLEKKLKITQKERKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 146, "header": "tr|A0ABI0NKS2-1|A0ABI0NKS2_BOVIN Computationally mapped isoform of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=1 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135761352, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105403.1" } ] } }, { "isoform_ac": "A0ABI0NPB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0ABI0NPB5-1", "sequence": { "sequence": "MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPPSGLLPSGQPGSPSRKTAGSPTM", "length": 143, "header": "tr|A0ABI0NPB5-1|A0ABI0NPB5_BOVIN Computationally mapped isoform of SUZ RNA binding domain containing 1 OS=Bos taurus OX=9913 GN=SZRD1 PE=4 SV=1 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135759372, "end_pos": 135740033, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140253.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140253.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107714.1" } ] } }, { "isoform_ac": "A0ABI0P4E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5/entry#A0ABI0P4E2-1", "sequence": { "sequence": "MDCSLPGSSVHGIFQARIMEWIAISFSKEIDRRLEKKLKITQKESRKSKSPPKVPIVIQDDSLPAGPPPQIRILKRPTSNGVVSGPNSASRPALPVKSLAQREAEYAEARKRILGSASPEEEQEKPILDRPTRISQPEDSRQPNNVIRQPLGPDGSQGFKQRR", "length": 163, "header": "tr|A0ABI0P4E2-1|A0ABI0P4E2_BOVIN Computationally mapped isoform of SUZ RNA-binding domain-containing OS=Bos taurus OX=9913 GN=SZRD1 PE=3 SV=1 CANONICAL=A0AAA9SUM5-1" }, "locus": { "chromosome": "2", "start_pos": 135759909, "end_pos": 135739980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148728.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148728.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106175.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106175.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5" }, { "id": "PS51673", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51673" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUZ", "eco_id": "ECO_0000259", "start_pos": 102, "end_pos": 167, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM5" }, { "id": "PS51938", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51938" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUZ-C", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 212, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSR3-1", "uniprot_ac": "A0AAA9SSR3", "uniprot_id": "A0AAA9SSR3_BOVIN", "mass": { "chemical_mass": 78366.0, "monoisotopic_mass": 78366.0 }, "refseq": { "ac": "XP_010818485", "name": "leucine-rich repeat-containing protein 27 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818485" }, "gene_names": [ { "name": "LRRC27", "type": "recommended", "evidence": [ { "id": "A0AAA9SSR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3" } ] }, { "name": "LRRC27", "type": "synonym", "evidence": [ { "id": "XP_010818485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818485" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 27", "type": "synonym", "evidence": [ { "id": "A0AAA9SSR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 27 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_010818485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818485" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3", "locus": { "chromosome": "26", "start_pos": 51963277, "end_pos": 51935409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003800", "url": "https://www.ensembl.org/id/ENSBTAG00000003800" } ] } } ], "crossref": [ { "id": "A0AAA9SSR3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003800", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003800", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614529", "url": "https://www.ncbi.nlm.nih.gov/gene/614529", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614529", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614529", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MIPKDFF", "url": "https://omabrowser.org/oma/group/MIPKDFF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKA5", "url": "https://www.orthodb.org/?gene=E1BKA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010818485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7S1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7S1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6C0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6C0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKA5", "url": "https://www.uniprot.org/uniprotkb/E1BKA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGSGSLSVPCGAGDRESQAGSKPASASRDVHQGVIFSSSAILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSVTTLKALSLRHCPLEFPPPLVVQRGLVAILTFLQICAADHEAPHDGSPRVKKMTVRDLPQPLLELSEEHVPNKETIRSQEPKGSMVTEKADFFPPVETLDPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALGNQLLPAELPPSLRAALSSRGKPLPRPRPLCRMKIPSFQGVLPELDSTRQALVRTSQLGKSRGLALQELRERQAQEQSKSAHVLLPAPRHPPQRQAIAARVEGEYPGDEEKAGGAREPASPAPAEEPAVTSRRKQRPPARPPCPGLRRQHPCSPAARLPRSSLWALRPLPRSSSLTCLQLRPGSSQRGSHSSAASSGGLCRPGNPPPASSFPGPVRAVLAPHPTRSLPRAIPRPGRSSVVLPKQLCPGVQASSPALLRAALCLQLRTPVCETPVMKSLCPCPGPQGPPTAHALCPGPSPPGVSSERGWGWSPYPSTCTGSRLQAAAGQTVRAPCPSRPPGPAMQDALACCPSGVPWLPLLPSAGSRPAWVLIWQRKGPRSWAQGPQAGLRSAVQATGHETGSRPPPLPQGPGGPFPSTCTPCPLAPRSLFMVMRAPPPTQSTEGIVKVTPRDQDPPWAWV", "length": 727, "header": "tr|A0AAA9SSR3-1|A0AAA9SSR3_BOVIN Isoform 1 of Leucine rich repeat containing 27 OS=Bos taurus OX=9913 GN=LRRC27 PE=4 SV=1 CANONICAL=A0AAA9SSR3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7S1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3/entry#A0AAA9S7S1-1", "sequence": { "sequence": "MEGSGSLSVPCGAGDRESQAGSKPASASRDVHQGVIFSSSAILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSVTTLKALSLRHCPLEFPPPLVVQRGLVAILTFLQICAADHEAPHDGSPRVKKMTVRDLPQPLLELSEEHVPNKETIRSQEPKGSMVTEKADFFPPVETLDPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALGNQLLPAELPPSLRAALSSRGKPLPRPRPLCRMKIPSFQGVLPELDSTRQALVRTSQLGKSRGLALQELRERQAQEQSKRDKRLLQEWRESTQVMRRRQEEPGSLPAPPPRRNPGAAKIAFATDPRENKKTPKNSPGKATQSKEKPLGLRGQILEETLKPQTQQLHARRSRFRGLAPLEDVGKAARDAEMARRLHDEVLKLRLRSALNRNHQCAALPRSLSLRPAVSRPQNIFFNPKY", "length": 505, "header": "tr|A0AAA9S7S1-1|A0AAA9SSR3_BOVIN Computationally mapped isoform of Leucine rich repeat containing 27 OS=Bos taurus OX=9913 GN=LRRC27 PE=4 SV=1 CANONICAL=A0AAA9SSR3-1" }, "locus": { "chromosome": "26", "start_pos": 51962273, "end_pos": 51937654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123885.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123885.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081286.1" } ] } }, { "isoform_ac": "A0AAA9SRK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3/entry#A0AAA9SRK9-1", "sequence": { "sequence": "MTEQQQPGARGSSWPVLTLGSVRAGAQVRLRPHTMPFLRRLTSLAGGRCAADSPLQSSFCFSSSWARSVCSFLTWVPTSAGHPGFASLLVTPHPGGCAVVPRGVLPPGGLMEGSGSLSVPCGAGDRESQAGSKPASASRDVHQGVIFSSSAILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSVTTLKALSLRHCPLEFPPPLVVQRGLVAILTFLQICAADHEAPHDGSPRVKKMTVRDLPQPLLELSEEHVPNKETIRSQEPKGSMVTEKADFFPPVETLDPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALGNQLLPAELPPSLRAALSSRGKPLPRPRPLCRMKIPSFQGVLPELDSTRQALVRTSQLGKSRGLALQELRERQAQEQSKSAHVLLPAPRHPPQRQAIAARVEGEYPGDEEKAGGAREPASPAPAEEPGGSKDCLCHGPEREQEDTEEFAWKSDTKQREAAVSTSGDEVGSLRGNRRESILLDTPLPPAPTPEAPAPSTGSSSGPRALEEGGCAVTCGWQRARSSIILEIGKVSRVHQWVKAAIWGGLTCS", "length": 627, "header": "tr|A0AAA9SRK9-1|A0AAA9SSR3_BOVIN Computationally mapped isoform of Leucine rich repeat containing 27 OS=Bos taurus OX=9913 GN=LRRC27 PE=4 SV=1 CANONICAL=A0AAA9SSR3-1" }, "locus": { "chromosome": "26", "start_pos": 51960413, "end_pos": 51935608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123259.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123259.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085608.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085608.1" } ] } }, { "isoform_ac": "A0AAA9SSR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3/entry#A0AAA9SSR3-1", "sequence": { "sequence": "MEGSGSLSVPCGAGDRESQAGSKPASASRDVHQGVIFSSSAILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSVTTLKALSLRHCPLEFPPPLVVQRGLVAILTFLQICAADHEAPHDGSPRVKKMTVRDLPQPLLELSEEHVPNKETIRSQEPKGSMVTEKADFFPPVETLDPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALGNQLLPAELPPSLRAALSSRGKPLPRPRPLCRMKIPSFQGVLPELDSTRQALVRTSQLGKSRGLALQELRERQAQEQSKSAHVLLPAPRHPPQRQAIAARVEGEYPGDEEKAGGAREPASPAPAEEPAVTSRRKQRPPARPPCPGLRRQHPCSPAARLPRSSLWALRPLPRSSSLTCLQLRPGSSQRGSHSSAASSGGLCRPGNPPPASSFPGPVRAVLAPHPTRSLPRAIPRPGRSSVVLPKQLCPGVQASSPALLRAALCLQLRTPVCETPVMKSLCPCPGPQGPPTAHALCPGPSPPGVSSERGWGWSPYPSTCTGSRLQAAAGQTVRAPCPSRPPGPAMQDALACCPSGVPWLPLLPSAGSRPAWVLIWQRKGPRSWAQGPQAGLRSAVQATGHETGSRPPPLPQGPGGPFPSTCTPCPLAPRSLFMVMRAPPPTQSTEGIVKVTPRDQDPPWAWV", "length": 727, "header": "tr|A0AAA9SSR3-1|A0AAA9SSR3_BOVIN Isoform 1 of Leucine rich repeat containing 27 OS=Bos taurus OX=9913 GN=LRRC27 PE=4 SV=1 CANONICAL=A0AAA9SSR3-1" }, "locus": { "chromosome": "26", "start_pos": 51956051, "end_pos": 51937654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089432.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089432.1" } ] } }, { "isoform_ac": "A0ABI0P6C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3/entry#A0ABI0P6C0-1", "sequence": { "sequence": "MEGSGSLSVPCGAGDRESQAGSKPASASRDVHQGVIFSSSAILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSVTTLKALSLRHCPLEFPPPLVVQRGLVAILTFLQICAADHEAPHDGSPRVKKMTVRDLPQPLLELSEEHVPNKETIRSQEPKGSMVTEKADFFPPVETLDPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALGNQLLPAELPPSLRAALSSRGKPLPRPRPLCRMKIPSFQGVLPELDSTRQALVRTSQLGKSRGLALQELRERQAQEQSKSAHVLLPAPRHPPQRQAIAARVEGEYPGDEEKAGGAREPASPAPAEEPGGSKDCLCHGPEREQEDTEEFAWKSDTKQREAAVSTSGDEWSPRADSGGDAEATDPAAARAEEQVQGAGTPRGRREGRPGRGDGDCPLKPGGSHTHRL", "length": 492, "header": "tr|A0ABI0P6C0-1|A0ABI0P6C0_BOVIN Computationally mapped isoform of Leucine rich repeat containing 27 OS=Bos taurus OX=9913 GN=LRRC27 PE=4 SV=1 CANONICAL=A0AAA9SSR3-1" }, "locus": { "chromosome": "26", "start_pos": 51961204, "end_pos": 51937654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143600.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143600.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107009.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107009.1" } ] } }, { "isoform_ac": "E1BKA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR3/entry#E1BKA5-1", "sequence": { "sequence": "MEGSGSLSVPCGAGDRESQAGSKPASASRDVHQGVIFSSSAILDLSQSGLHHFGEIFKVPNLKQLHLQRNALCTIPKDFFQLLPNLSWLDLRFNRITALPSGIGCHKHLKTLLLERNPIRMLPVELGSVTTLKALSLRHCPLEFPPPLVVQRGLVAILTFLQICAADHEAPHDGSPRVKKMTVRDLPQPLLELSEEHVPNKETIRSQEPKGSMVTEKADFFPPVETLDPHEPRRSTEPPEDWPSEEEIRRFWKLRQEIVENEQAGALGNQLLPAELPPSLRAALSSRGKPLPRPRPLCRMKIPSFQGVLPELDSTRQALVRTSQLGKSRGLALQELRERQAQEQSKRDKRLLQEWRESTQVMRRRQEEPGSLPAPPPRRNPLRTPVCETPVMKSLCPCPGPQGPPTAHALCPGPSPPGPARRITAAGWLEWGHGSPQQSSKNTPQQQGAGHLQEHRVCTEPRALGVHVGAKEVRAHTGEFHPGIQVWPA", "length": 489, "header": "tr|E1BKA5-1|A0AAA9SSR3_BOVIN Computationally mapped isoform of Leucine rich repeat containing 27 OS=Bos taurus OX=9913 GN=LRRC27 PE=4 SV=3 CANONICAL=A0AAA9SSR3-1" }, "locus": { "chromosome": "26", "start_pos": 51958788, "end_pos": 51937654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004943.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004943.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004943.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004943.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 706, "start_aa": "Thr", "end_pos": 706, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr706", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614529", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614529", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q80YS5-1", "protein_name": "Leucine-rich repeat-containing protein 27", "gene_name": "Lrrc27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDTSPQAVAEKAAKDPKAAKDLKDDAAAATKSFPDHFSREGDDQMDFEGVIFSSSPVLDLSQRGLRHLGKFFKIPNLQQLHLQRNLLREIPEDFFQLLPNLTWLDLRYNKIKVLPSGIGSHKHLKTLLLERNPIKMLPVELGQVTTLTALNLRHCPLEFPPRLIVQKGLVAILTFLRICSVEKAFPGDELLPEVSAPKMGSNDLQYPVLPLPRKGSPSENSLNDPDQEKEKADFFPPMERLDLSELRKSNAASEIWPSKEEIRRFWKLRQEIVENEQVEIQEKKLLAVELPPNLKAALNVKEKKHRKPWPAVRKRSTSFKGILPNLPSGYQNTVHANRMEDTHKAALQELQEKETVLEQRRRDKRALQEWREQTQHMRTRRELSKLQPPHSNMMASKIPFATDLTDYEKMPVSPFGKVKPSGEGTAQRPIEISASPLAELEDKIKRHTQQIRTRSFLGTNPMQDIKTANQDLETTKKLQEELRKLKVEMTLNKDHPFPSFTGNLSLHPPASQPQNIFFNTKS", "length": 523 }, "evidence": [ { "id": "A0AAA9SSR3", "url": "https://omabrowser.org/oma/group/A0AAA9SSR3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C0I9-1", "protein_name": "Leucine-rich repeat-containing protein 27", "gene_name": "LRRC27", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGSSSYEVPSVAAADLEEGAGQTRSLPATPSKDVHKGVGGIIFSSSPILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPVELGSVTTLKALNLRHCPLEFPPQLVVQKGLVAIQRFLRMWAVEHSLPRNPTSQEAPPVREMTLRDLPSPGLELSGDHASNQGAVNAQDPEGAVMKEKASFLPPVEKPDLSELRKSADSSENWPSEEEIRRFWKLRQEIVEHVKADVLGDQLLTRELPPNLKAALNIEKELPKPRHVFRRKTASSRSILPDLLSPYQMAIRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKIPSATDLIDNRKVPLNPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAEDLEIATELQDEVLKLKLGLTLNKDRRRAALTGNLSLGLPAAQPQNTFFNTKYGESGNVRRYQ", "length": 530 }, "evidence": [ { "id": "A0AAA9SSR3", "url": "https://omabrowser.org/oma/group/A0AAA9SSR3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 706 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSS7-1", "uniprot_ac": "A0AAA9SSS7", "uniprot_id": "A0AAA9SSS7_BOVIN", "mass": { "chemical_mass": 36832.0, "monoisotopic_mass": 36832.0 }, "refseq": {}, "gene_names": [ { "name": "LOC782884", "type": "recommended", "evidence": [ { "id": "A0AAA9SSS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ] } ], "protein_names": [ { "name": "NADP-dependent oxidoreductase domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SSS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC782884", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SSS7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSS7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021368", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051758", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051758", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527068", "url": "https://www.ncbi.nlm.nih.gov/gene/527068", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782884", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782884", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BP71", "url": "https://www.orthodb.org/?gene=E1BP71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "M0QW04", "url": "https://www.orthodb.org/?gene=M0QW04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11732", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-193368", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193368", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-193775", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193775", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-193807", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193807", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2162123", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2162123", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5365859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9757110", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9757110", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP71", "url": "https://www.uniprot.org/uniprotkb/E1BP71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP71-1", "url": "https://www.uniprot.org/uniprotkb/E1BP71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QW04", "url": "https://www.uniprot.org/uniprotkb/M0QW04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QW04-1", "url": "https://www.uniprot.org/uniprotkb/M0QW04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPKSQRVKLNDGHFIPALGFGTGAPPEVPKSEAVEVTKFAIEVGFRHIDSAHLYQNEEQVGQAIRSKIADGTVKREDIFYTSKVWSTFLRPELVRPALEKSLKDLQLDYVDLYIIHYPVPLVPGETLLPTDENGKPIFDSVDLCLTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSHDIVLVAYGALGAQRTLQWMNPNFPFLLEDPVLSAIAKKHKQTPALVALRYQIQRGVVVLAKSYNKKRIKENIQVFDFELTLEDMKAIDGLNSNIRYYDFQHVVDHPEYPYSEEY", "length": 323, "header": "tr|A0AAA9SSS7-1|A0AAA9SSS7_BOVIN Isoform 1 of NADP-dependent oxidoreductase domain-containing protein OS=Bos taurus OX=9913 GN=LOC782884 PE=3 SV=2 CANONICAL=A0AAA9SSS7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7/entry#A0AAA9SSS7-1", "sequence": { "sequence": "MDPKSQRVKLNDGHFIPALGFGTGAPPEVPKSEAVEVTKFAIEVGFRHIDSAHLYQNEEQVGQAIRSKIADGTVKREDIFYTSKVWSTFLRPELVRPALEKSLKDLQLDYVDLYIIHYPVPLVPGETLLPTDENGKPIFDSVDLCLTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSHDIVLVAYGALGAQRTLQWMNPNFPFLLEDPVLSAIAKKHKQTPALVALRYQIQRGVVVLAKSYNKKRIKENIQVFDFELTLEDMKAIDGLNSNIRYYDFQHVVDHPEYPYSEEY", "length": 323, "header": "tr|A0AAA9SSS7-1|A0AAA9SSS7_BOVIN Isoform 1 of NADP-dependent oxidoreductase domain-containing protein OS=Bos taurus OX=9913 GN=LOC782884 PE=3 SV=2 CANONICAL=A0AAA9SSS7-1" }, "locus": { "chromosome": "13", "start_pos": 43711279, "end_pos": 43646547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128970.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128970.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086082.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086082.2" } ] } }, { "isoform_ac": "E1BP71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7/entry#E1BP71-1", "sequence": { "sequence": "MDPKSQRVKLNDGHFIPALGFGTGAPPEVPKSEAVEVTKFAIEAGFRHIDSAYTYQNEEQVGQAIRSKIADGTVKREDIFYTSKVWSTFLRPDLVRPALEKSLKDLQLDYVDLYIIHQPVALMPGETLFPTDENGKPMFDSVDLCRTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSHNIVLVAYGALGAQRTLQWVNPNLPFLLEDPVLSAIAKKHKQTPALVALRYQIQRGVVVLAKSYNKKRIKENIQVFDFELTLEDMKAIDGLNSNIRYYDFQQAVDHPEYPYSEEY", "length": 323, "header": "tr|E1BP71-1|E1BP71_BOVIN Computationally mapped isoform of NADP-dependent oxidoreductase domain-containing protein OS=Bos taurus OX=9913 GN=LOC782884 PE=3 SV=3 CANONICAL=A0AAA9SSS7-1" }, "locus": { "chromosome": "13", "start_pos": 43664942, "end_pos": 43646547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039350.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039350.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039145.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039145.6" } ] } }, { "isoform_ac": "M0QW04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7/entry#M0QW04-1", "sequence": { "sequence": "MDPKSQRVKLNDGHFIPALGFGTGAPPEVPKSEAVEVTKFAIEAGFRHIDSAYTYQNEEQVGQAIRSKIADGTVKREDIFYTSKVWSTFLRPDLVRPALEKSLKDLQLDYVDLYIIHQPVALMPGETLFPTDENGKPMFDSVDLCRTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECHPYLNQSKLLEFCKSHDIVLVAYGALGAQRTLQWMNPNFPFLLEDPVLSAIAKKHKQTPALVALRYQIQRGVVVLAKSYNKKRIKENIQVFDFELTLEDMKAIDGLNSNIRYYDFQHVVDHPEYPYSEEY", "length": 323, "header": "tr|M0QW04-1|M0QW04_BOVIN Computationally mapped isoform of NADP-dependent oxidoreductase domain-containing protein OS=Bos taurus OX=9913 GN=LOC782884 PE=3 SV=4 CANONICAL=A0AAA9SSS7-1" }, "locus": { "chromosome": "13", "start_pos": 43711279, "end_pos": 43646547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014388.8", "url": "https://www.ensembl.org/id/ENSBTAT00000014388.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014388.8", "url": "https://www.ensembl.org/id/ENSBTAP00000014388.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782884", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782884", "resource": "KEGG Pathway" }, { "id": "R-BTA-193368", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193368", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" }, { "id": "R-BTA-193775", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193775", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" }, { "id": "R-BTA-193807", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193807", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" }, { "id": "R-BTA-2162123", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2162123", "resource": "Reactome", "description": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" }, { "id": "R-BTA-5365859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5365859", "resource": "Reactome", "description": "RA biosynthesis pathway" }, { "id": "R-BTA-975634", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "resource": "Reactome", "description": "Retinoid metabolism and transport" }, { "id": "R-BTA-9757110", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9757110", "resource": "Reactome", "description": "Prednisone ADME" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "aldose reductase (NADPH) activity", "id": "GO:0004032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "androsterone dehydrogenase [NAD(P)+] activity", "id": "GO:0047023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "bile acid binding", "id": "GO:0032052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "ketosteroid monooxygenase activity", "id": "GO:0047086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "prostaglandin metabolic process", "id": "GO:0006693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "daunorubicin metabolic process", "id": "GO:0044597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "doxorubicin metabolic process", "id": "GO:0044598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044598", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" }, { "name": "progesterone metabolic process", "id": "GO:0042448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042448", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS7" }, { "id": "PF00248", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADP-dependent oxidoreductase", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 300, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSP8-1", "uniprot_ac": "A0AAA9SSP8", "uniprot_id": "A0AAA9SSP8_BOVIN", "mass": { "chemical_mass": 169587.0, "monoisotopic_mass": 169587.0 }, "refseq": {}, "gene_names": [ { "name": "TEX14", "type": "recommended", "evidence": [ { "id": "A0AAA9SSP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ] } ], "protein_names": [ { "name": "Inactive serine/threonine-protein kinase TEX14", "type": "recommended", "evidence": [ { "id": "A0AAA9SSP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8/entry#names_and_taxonomy" } ] }, { "name": "Testis-expressed sequence 14 protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SSP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8/entry#names_and_taxonomy" } ] }, { "name": "Testis-expressed sequence 14", "type": "synonym", "evidence": [ { "id": "A0AAA9SSP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YUN4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUN4#function" }, { "database": "UniProtKB", "id": "ARBA00057673", "url": "https://www.uniprot.org/uniprotkb/ARBA00057673#function" }, { "database": "UniProtKB", "id": "A0AAA9SDF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF9#function" }, { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TEX14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8", "locus": { "chromosome": "19", "start_pos": 9512391, "end_pos": 9572825, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010167", "url": "https://www.ensembl.org/id/ENSBTAG00000010167" } ] } } ], "crossref": [ { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23060:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23060:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUN4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNIQDGFSSEWTSWISLQSKGLSRVFSNTTVQKHQFFGIYVDAVNSLGQTALFIAALLGLTKLVDVLVDYGADPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDEKGRNPQTWALAAGKERSTVMVEFMQRCAAHMQAIIQGFSDLLKKIDSPQRLISGVPRFGGLMQGNPNGSPNRPPKAGVISAQNIYSFGFGKFYLTGGTQLAYLGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELHLSTHPHCSRLRMADLLIAEQEHSSKLRHPHVLQLMAVCLSPDLEKTRLVYERVTVGTLFSVLHERRAQFPVLHMEVIVHLLLQISDALRYLHSRGFIHRSLSSYAIHIVSTGEARLTNLEYMMESQDGGAHRGLTRVPLPTQLYNWAAPEVIIQKAATVKSDIYSFSVIVQEILTDNIPWDGLDGSVIKETIVLGNYLEADVRLPKPYYDIVKSGLQVKQKDRTMNLQDIRYIMKNDLKDFIGAQRTQPTESPRVQRYEFHPDVNVCLGLTSEHPKETPNLEIKELKETAGSQFHSPRGHSSPTGKATPEPPVPDVSPVAQQTHRQDAASPACSVAEEARNPSPDQTSLCSFEINEIYSGCLDTADDPEEECPGTGSSLEGAIPNQTDELKSMEEELEKMEREVCCSCDEDESSSDADTELSCEDWEWQNDALCSPSRPEPARGAKGATNNRSMTEEYISKCVLNLKISQTLIHQNADLLRNVQQKIEKLEMIQKEQAERRSLWASSREFAGIHDSPSALGPPASSYLPPVVQRPGDQQLDPGGSGLTLARSPRTVKDFRGGHFGKRSKKRSDCGWTPLASFPQVTEEITRDQPEKDHQLPTLCGPGKQSRGEQFQPTHGAKASLERDRNQNTSSQGRPRESSPQSKTTQLSSALLTVPSHPQGSPTSSKPGQDSTRISMQSVSSEIYNAKSRNNKDDGEIHLKWKTEVKEMAAKAATGQLTVPPWHPRSGVALDSEAENEPDPLPQLPIRVSEHMDWQQAADYLKKSDEPGGNDKCGQTDSSDQRGRQSGPQRFTSIRHLPPREDEQPEHSEVFQANSDASVAVEKSYSGQSAQSTCSPESSEDTEDMTDEFLTPDHEYFYSSIAQENLALETSSPIDEDFEGIQHACARPQASGEEKFQMRKNLGKNSEILTKSQFQPIRSPEGEQDETLKEPPKEVKEKDISLTDIQDLSSISCEHDGSFKEVSCKTPKINHAPTSVSTPLSPGSLSSVASQYKDCLESIPFQDTKTGSTSCGTSQESTQTLSDKFTSVREKAKSLDSLLTSSEVLPARLTNLKRLPAFTGAGSSSIAKAPDTSRCATQRRSLPKELVEAISQHHIDELPPPSQELLDEIEHLKGQQVSSTALDENTASRPGSTENDQRHLEEQETHSNKEDSSMLWTKETQDLEEDTERAHSTLDEDLERWLQPPEDSTQLPDLPKGPAREASSKDQEVGEKKRKGEESTKPEKRKPESFLGTSEEEELKPCFWKRLGWSEPSRIIVLDQSDLSD", "length": 1530, "header": "tr|A0AAA9SSP8-1|A0AAA9SSP8_BOVIN Isoform 1 of Inactive serine/threonine-protein kinase TEX14 OS=Bos taurus OX=9913 GN=TEX14 PE=3 SV=1 CANONICAL=A0AAA9SSP8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8/entry#A0AAA9SDF9-1", "sequence": { "sequence": "MNIQDGFSSEWTSWISLQSKGLSRVFSNTTVQKHQFFGIYVDAVNSLGQTALFIAALLGLTKLVDVLVDYGADPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDEKGRNPQTWALAAGKERSTVMVEFMQRCAAHMQAIIQGFSDLLKKIDSPQRLISGVPRFGGLMQGNPNGSPNRPPKAGVISAQNIYSFGFGKFYLTGGTQLAYLGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELHLSTHPHCSRLRMADLLIAEQEHSSKLRHPHVLQLMAVCLSPDLEKTRLVYERVTVGTLFSVLHERRAQFPVLHMEVIVHLLLQISDALRYLHSRGFIHRSLSSYAIHIVSTGEARLTNLEYMMESQDGGAHRGLTRVPLPTQLYNWAAPEVIIQKAATVKSDIYSFSVIVQEILTDNIPWDGLDGSVIKETIVLGNYLEADVRLPKPYYDIVKSGLQVKQKDRTMNLQDIRYIMKNDLKDFIGAQRTQPTESPRVQRYEFHPDVNVCLGLTSEHPKETPNLEIKELKETAGSQFHSPRGHSSPTGKATPEPPVPDVSPVAQQTHRQDAASPACSVAEEARNPSPDQTSLCSFEINEIYSGCLDTADDPEEECPGTGSSLEGAIPNQTDELKSMEEELEKMEREVCCSCDEDESSSDADTELSCEDWEWQNDALCSPSRPEPARGAKGATNNRSMTEEYISKCVLNLKISQTLIHQNADLLRNVQQKIEKLEMIQKEQAERRSLWASSREFAGIHDSPSALGPPASSYLPPVVQRPGDQQLDPGGSGLTLARSPRTVKDFRGGHFGKRSKKRSDCGWTPLASFPQVTEEITRDQPEKDHQLPTLCGPGKQSRGEQFQPTHGAKASLERDRNQNTSSQGRPRESSPQSKTTQLSSALLTVPSHPQGSPTSSKPGQDSTRISMQSVSSEIYNAKSRNNKDDGEIHLKWKSIRHLPPREDEQPEHSEVFQANSDASVAVEKSYSGQSAQSTCSPESSEDTEDMTDEFLTPDHEYFYSSIAQENLALETSSPIDEDFEGIQHACARPQASGEEKFQMRKNLGKNSEILTKSQFQPIRSPEGEQDETLKEPPKEVKEKDISLTDIQDLSSISCEHDGSFKEVSCKTPKINHAPTSVSTPLSPGSLSSVASQYKDCLESIPFQDTKTGSTSCGTSQESTQTLSDKFTSVREKAKSLDSLLTSSEVLPARLTNLKRLPAFTGAGSSSIAKAPDTSRCATQRRSLPKELVEAISQHHIDELPPPSQELLDEIEHLKGQQVSSTALDENTASRPGSTENDQRHLEEQETHSNKEDSSMLWTKETQDLEEDTERAHSTLDEDLERWLQPPEDSTQLPDLPKGPAREASSKDQEVGEKKRKGEESTKPEKRKPESFLGTSEEEELKPCFWKRLGWSEPSRIIVLDQSDLSD", "length": 1440, "header": "tr|A0AAA9SDF9-1|A0AAA9SSP8_BOVIN Computationally mapped isoform of Inactive serine/threonine-protein kinase TEX14 OS=Bos taurus OX=9913 GN=TEX14 PE=3 SV=1 CANONICAL=A0AAA9SSP8-1" }, "locus": { "chromosome": "19", "start_pos": 9572263, "end_pos": 9512720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129130.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129130.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084170.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084170.1" } ] } }, { "isoform_ac": "A0AAA9SSP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8/entry#A0AAA9SSP8-1", "sequence": { "sequence": "MNIQDGFSSEWTSWISLQSKGLSRVFSNTTVQKHQFFGIYVDAVNSLGQTALFIAALLGLTKLVDVLVDYGADPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDEKGRNPQTWALAAGKERSTVMVEFMQRCAAHMQAIIQGFSDLLKKIDSPQRLISGVPRFGGLMQGNPNGSPNRPPKAGVISAQNIYSFGFGKFYLTGGTQLAYLGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELHLSTHPHCSRLRMADLLIAEQEHSSKLRHPHVLQLMAVCLSPDLEKTRLVYERVTVGTLFSVLHERRAQFPVLHMEVIVHLLLQISDALRYLHSRGFIHRSLSSYAIHIVSTGEARLTNLEYMMESQDGGAHRGLTRVPLPTQLYNWAAPEVIIQKAATVKSDIYSFSVIVQEILTDNIPWDGLDGSVIKETIVLGNYLEADVRLPKPYYDIVKSGLQVKQKDRTMNLQDIRYIMKNDLKDFIGAQRTQPTESPRVQRYEFHPDVNVCLGLTSEHPKETPNLEIKELKETAGSQFHSPRGHSSPTGKATPEPPVPDVSPVAQQTHRQDAASPACSVAEEARNPSPDQTSLCSFEINEIYSGCLDTADDPEEECPGTGSSLEGAIPNQTDELKSMEEELEKMEREVCCSCDEDESSSDADTELSCEDWEWQNDALCSPSRPEPARGAKGATNNRSMTEEYISKCVLNLKISQTLIHQNADLLRNVQQKIEKLEMIQKEQAERRSLWASSREFAGIHDSPSALGPPASSYLPPVVQRPGDQQLDPGGSGLTLARSPRTVKDFRGGHFGKRSKKRSDCGWTPLASFPQVTEEITRDQPEKDHQLPTLCGPGKQSRGEQFQPTHGAKASLERDRNQNTSSQGRPRESSPQSKTTQLSSALLTVPSHPQGSPTSSKPGQDSTRISMQSVSSEIYNAKSRNNKDDGEIHLKWKTEVKEMAAKAATGQLTVPPWHPRSGVALDSEAENEPDPLPQLPIRVSEHMDWQQAADYLKKSDEPGGNDKCGQTDSSDQRGRQSGPQRFTSIRHLPPREDEQPEHSEVFQANSDASVAVEKSYSGQSAQSTCSPESSEDTEDMTDEFLTPDHEYFYSSIAQENLALETSSPIDEDFEGIQHACARPQASGEEKFQMRKNLGKNSEILTKSQFQPIRSPEGEQDETLKEPPKEVKEKDISLTDIQDLSSISCEHDGSFKEVSCKTPKINHAPTSVSTPLSPGSLSSVASQYKDCLESIPFQDTKTGSTSCGTSQESTQTLSDKFTSVREKAKSLDSLLTSSEVLPARLTNLKRLPAFTGAGSSSIAKAPDTSRCATQRRSLPKELVEAISQHHIDELPPPSQELLDEIEHLKGQQVSSTALDENTASRPGSTENDQRHLEEQETHSNKEDSSMLWTKETQDLEEDTERAHSTLDEDLERWLQPPEDSTQLPDLPKGPAREASSKDQEVGEKKRKGEESTKPEKRKPESFLGTSEEEELKPCFWKRLGWSEPSRIIVLDQSDLSD", "length": 1530, "header": "tr|A0AAA9SSP8-1|A0AAA9SSP8_BOVIN Isoform 1 of Inactive serine/threonine-protein kinase TEX14 OS=Bos taurus OX=9913 GN=TEX14 PE=3 SV=1 CANONICAL=A0AAA9SSP8-1" }, "locus": { "chromosome": "19", "start_pos": 9572263, "end_pos": 9512720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106166.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106166.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089411.1" } ] } }, { "isoform_ac": "A0AAF6YUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8/entry#A0AAF6YUN4-1", "sequence": { "sequence": "MSSFLLVLFTWGIYVDAVNSLGQTALFIAALLGLTKLVDVLVDYGADPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDEKGRNPQTWALAAGKERSTVMVEFMQRCAAHMQAIIQGFSDLLKKIDSPQRLISGVPRFGGLMQGNPNGSPNRPPKAGVISAQNIYSFGFGKFYLTGGTQLAYLGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELHLSTHPHCSRLRMADLLIAEQEHSSKLRHPHVLQLMAVCLSPDLEKTRLVYERVTVGTLFSVLHERRAQFPVLHMEVIVHLLLQISDALRYLHSRGFIHRSLSSYAIHIVSTGEARLTNLEYMMESQDGGAHRGLTRVPLPTQLYNWAAPEVIIQKAATVKSDIYSFSVIVQEILTDNIPWDGLDGSVIKETIVLGNYLEADVRLPKPYYDIVKSGLQVKQKDRTMNLQDIRYIMKNDLKDFIGAQRTQPTESPRVQRYEFHPDVNVCLGLTSEHPKETPNLEIKELKETAGSQFHSPRGHSSPTGKATPEPPVPDVSPVAQQTHRQDAASPACSVAEEARNPSPDQTSLCSFEINEIYSGCLDTADDPEEECPGTGSSLEGAIPNQTDELKSMEEELEKMEREVCCSCDEDESSSDADTELSCEDWEWQNDALCSPSRPEPARGAKGATNNRSMTEEYISKCVLNLKISQTLIHQNADLLRNVQQKIEKLEMIQKEQAERRSLWASSREFAGIHDSPSALGPPASSYLPPVVQRPGDQQLDPGGSGLTLARSPRTVKDFRGGHFGKRSKKRSDCGWTPLASFPQVTEEITRDQPEKDHQLPTLCGPGKQSRGEQFQPTHGAKASLERDRNQNTSSQGRPRESSPQSKTTQLSSALLTVPSHPQGSPTSSKPGQDSTRISMQSVSSEIYNAKSRNNKDDGEIHLKWKTEVKEMAAKAATGQLTVPPWHPRSGVALDSEAENEPDPLPQLPIRVSEHMDWQQAADYLKKSDEPGGNDKCGQTDSSDQRGRQSGPQRFTSIRHLPPREDEQPEHSEVFQANSDASVAVEKSYSGQSAQSTCSPESSEDTEDMTDEFLTPDHEYFYSSIAQENLALETSSPIDEDFEGIQHACARPQASGEEKFQMRKNLGKNSEILTKSQFQPIRSPEGEQDETLKEPPKEVKEKDISLTDIQDLSSISCEHDGSFKEVSCKTPKINHAPTSVSTPLSPGSLSSVASQYKDCLESIPFQDTKTGSTSCGTSQESTQTLSDKFTSVREKAKSLDSLLTSSEVLPARLTNLKRLPAFTGAGSSSIAKAPDTSRCATQRRSLPKELVEAISQHHIDELPPPSQELLDEIEHLKGQQVSSTALDENTASRPGSTENDQRHLEEQETHSNKEDSSMLWTKETQDLEEDTERAHSTLDEDLERWLQPPEDSTQLPDLPKGPAREASSKDQEVGEKKRKGEESTKPEKRKPESFLGTSEEEELKPCFWKRLGWSEPSRIIVLDQSDLSD", "length": 1504, "header": "tr|A0AAF6YUN4-1|A0AAF6YUN4_BOVIN Computationally mapped isoform of Inactive serine/threonine-protein kinase TEX14 OS=Bos taurus OX=9913 GN=TEX14 PE=3 SV=1 CANONICAL=A0AAA9SSP8-1" }, "locus": { "chromosome": "19", "start_pos": 9572626, "end_pos": 9512720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013424.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013424.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013424.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013424.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "intercellular bridge organization", "id": "GO:0043063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043063", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "attachment of spindle microtubules to kinetochore", "id": "GO:0008608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008608", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "mitotic sister chromatid separation", "id": "GO:0051306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051306", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "mitotic spindle assembly checkpoint signaling", "id": "GO:0007094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 712, "end_pos": 714, "annotation": "n_glycosylation_sequon" }, { "start_pos": 893, "end_pos": 895, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSP8" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 190, "end_pos": 503, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 646, "end_pos": 648 }, { "start_pos": 712, "end_pos": 714 }, { "start_pos": 893, "end_pos": 895 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST20-1", "uniprot_ac": "A0AAA9ST20", "uniprot_id": "A0AAA9ST20_BOVIN", "mass": { "chemical_mass": 214327.0, "monoisotopic_mass": 214327.0 }, "refseq": { "ac": "XP_005211380", "name": "C-myc promoter-binding protein isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211380" }, "gene_names": [ { "name": "DENND4A", "type": "recommended", "evidence": [ { "id": "A0AAA9ST20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" } ] }, { "name": "DENND4A", "type": "synonym", "evidence": [ { "id": "XP_005211380", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211380" } ] } ], "protein_names": [ { "name": "C-myc promoter-binding protein isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005211380", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211380" } ] }, { "name": "DENN domain containing 4A", "type": "synonym", "evidence": [ { "id": "A0AAA9ST20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENND4A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20", "locus": { "chromosome": "10", "start_pos": 12556380, "end_pos": 12675106, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017095", "url": "https://www.ensembl.org/id/ENSBTAG00000017095" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017095", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017095", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514906", "url": "https://www.ncbi.nlm.nih.gov/gene/514906", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514906", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514906", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMTIAME", "url": "https://omabrowser.org/oma/group/LMTIAME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJE1", "url": "https://www.orthodb.org/?gene=E1BJE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12296:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12296:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005211380", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211380", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYJ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE1", "url": "https://www.uniprot.org/uniprotkb/E1BJE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJE1-1", "url": "https://www.uniprot.org/uniprotkb/E1BJE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVARPKEPITDVSVIIKSLGEEVPRDYTCIDITPTGLSADLNNGSLVGPQIFLCYRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRFLLGLASSANEKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLCFMASILKGYRSYLRPITQAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQTRKSKLPSKSSSPSSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVAQFKRALKKHANLSQTALSDGSDLDAVSHGSMDSGHGTHAVEQAPCSTGSIKAYASDDRSSTGGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDSSSLSECESAKGSADCLPKLGYQSSSSIVRLNGTSNSADKISGESTESTSEPLLISSFEDANETGNIQSRCFRKRHKSDNEPDLQQQMSWVNRSRNLSGGVLMGLMLSRINQEANPGNMVEKLGADAKILSNVISKSTRPNSLNIGKPSLRSKRDSVEKESSDDDTPFDGSNCLTDKVDSPVIFDLEDLDNETDISKARYIVPQNPKRSQRLNSSFSIKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEEEDDSKSVSTPSARRDLAEEIEMYMNNMSSPLTSRTPSIDLQRACDDKVTTKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYSKNEDRPRDRLWSSPAFSPTCPFREESQDALTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSQESSATSGTKGVDFSRTSLEGSASLEGSLSKFALPGKSEVASSCNTSNTNIFQNYAMEVLISSCSRCKTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNIEIRDLRRPGRYFLKSSPSTENIHFPSSFSSQTRQSCISTSTSGLDTSLLSVHGSFDLNSKSKPLENTCARSIQIPADRSKAAMSKCPLFPMARSVSTYGTLDQEDIGGQKLVPTGSLPTTLQGAADSLGLEWHLPSPDPITVPYLSPLVVWKELESLLENEGDRAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHSQNRTLLFETQKYPMVHLLQKGDNSFNQELLKNMVKSIKMNDVYGPMSQILDTLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1915, "header": "tr|A0AAA9ST20-1|A0AAA9ST20_BOVIN Isoform 1 of DENN domain containing 4A OS=Bos taurus OX=9913 GN=DENND4A PE=4 SV=1 CANONICAL=A0AAA9ST20-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20/entry#A0AAA9SDU8-1", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVARPKEPITDVSVIIKSLGEEVPRDYTCIDITPTGLSADLNNGSLVGPQIFLCYRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRFLLGLASSANEKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLCFMASILKGYRSYLRPITQAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQTRKSKLPSKSSSPSSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVAQFKRALKKHANLSQTALSGGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDSSSLSECESAKGSADCLPKLGYQSSSSIVRLNGTSNSADKISGESTESTSEPLLISSFEDANETGNIQSRCFRKRHKSDNEPDLQQQMSWVNRSRNLSGGVLMGLMLSRINQEANPGNMVEKLGADAKILSNVISKSTRPNSLNIGKPSLRSKRDSVEKESSDDDTPFDGSNCLTDKVDSPVIFDLEDLDNETDISKARYIVPQNPKRSQRLNSSFSIKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEEEDDSKSVSTPSARRDLAEEIEMYMNNMSSPLTSRTPSIDLQRACDDKVTTKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYSKNEDRPRDRLWSSPAFSPTCPFREESQDALTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSQESSATSGTKGVDFSRTSLEGSASLEGSLSKFALPGKSEVASSCNTSNTNIFQNYAMEVLISSCSRCKTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNIEIRDLRRPGRYFLKSSPSTENIHFPSSFSSQTRQSCISTSTSGLDTSLLSVHGSFDLNSKSKPLENTCARSIQIPADRSKAAMSKCPLFPMARSVSTYGTLDQEDIGGQKLVPTGSLPTTLQGAADSLGLEWHLPSPDPITVPYLSPLVVWKELESLLENEGDRAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKGDNSFNQELLKNMVKSIKMNDVYGPMSQILDTLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1863, "header": "tr|A0AAA9SDU8-1|A0AAA9ST20_BOVIN Computationally mapped isoform of DENN domain containing 4A OS=Bos taurus OX=9913 GN=DENND4A PE=4 SV=1 CANONICAL=A0AAA9ST20-1" }, "locus": { "chromosome": "10", "start_pos": 12638806, "end_pos": 12556964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132871.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132871.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084311.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084311.1" } ] } }, { "isoform_ac": "A0AAA9ST20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20/entry#A0AAA9ST20-1", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVARPKEPITDVSVIIKSLGEEVPRDYTCIDITPTGLSADLNNGSLVGPQIFLCYRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRFLLGLASSANEKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLCFMASILKGYRSYLRPITQAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQTRKSKLPSKSSSPSSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVAQFKRALKKHANLSQTALSDGSDLDAVSHGSMDSGHGTHAVEQAPCSTGSIKAYASDDRSSTGGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDSSSLSECESAKGSADCLPKLGYQSSSSIVRLNGTSNSADKISGESTESTSEPLLISSFEDANETGNIQSRCFRKRHKSDNEPDLQQQMSWVNRSRNLSGGVLMGLMLSRINQEANPGNMVEKLGADAKILSNVISKSTRPNSLNIGKPSLRSKRDSVEKESSDDDTPFDGSNCLTDKVDSPVIFDLEDLDNETDISKARYIVPQNPKRSQRLNSSFSIKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEEEDDSKSVSTPSARRDLAEEIEMYMNNMSSPLTSRTPSIDLQRACDDKVTTKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYSKNEDRPRDRLWSSPAFSPTCPFREESQDALTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSQESSATSGTKGVDFSRTSLEGSASLEGSLSKFALPGKSEVASSCNTSNTNIFQNYAMEVLISSCSRCKTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNIEIRDLRRPGRYFLKSSPSTENIHFPSSFSSQTRQSCISTSTSGLDTSLLSVHGSFDLNSKSKPLENTCARSIQIPADRSKAAMSKCPLFPMARSVSTYGTLDQEDIGGQKLVPTGSLPTTLQGAADSLGLEWHLPSPDPITVPYLSPLVVWKELESLLENEGDRAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHSQNRTLLFETQKYPMVHLLQKGDNSFNQELLKNMVKSIKMNDVYGPMSQILDTLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1915, "header": "tr|A0AAA9ST20-1|A0AAA9ST20_BOVIN Isoform 1 of DENN domain containing 4A OS=Bos taurus OX=9913 GN=DENND4A PE=4 SV=1 CANONICAL=A0AAA9ST20-1" }, "locus": { "chromosome": "10", "start_pos": 12638806, "end_pos": 12556964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087138.1" } ] } }, { "isoform_ac": "A0AAA9SYJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20/entry#A0AAA9SYJ9-1", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVARPKEPITDVSVIIKSLGEEVPRDYTCIDITPTGLSADLNNGSLVGPQIFLCYRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRFLLGLASSANEKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLCFMASILKGYRSYLRPITQAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQTRKSKLPSKSSSPSSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVAQFKRALKKHANLSQTALSDGSDLDAVSHGSMDSGHGTHAVEQAPCSTGSIKAYASDDRSSTGGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDSSSLSECESAKGSADCLPKLGYQSSSSIVRLNGTSNSADKISGESTESTSEPLLISSFEDANETGNIQSRCFRKRHKSDNEPDLQQQMSWVNRSRNLSGGVLMGLMLSRINQEANPGNMVEKLGADAKILSNVISKSTRPNSLNIGKPSLRSKRDSVEKESSDDDTPFDGSNCLTDKVDSPVIFDLEDLDNETDISKARYIVPQNPKRSQRLNSSFSIKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEEEDDSKSVSTPSARRDLAEEIEMYMNNMSSPLTSRTPSIDLQRACDDKVTTKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYSKNEDRPRDRLWSSPAFSPTCPFREESQDALTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSQESSATSGTKGVDFSRTSLEGSASLEGSLSKFALPGKSEVASSCNTSNTNIFQNYAMEVLISSCSRCKTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNIEIRDLRRPGRYFLKSSPSTENIHFPSSFSSQTRQSCISTSTSGLDTSLLSVHGSFDLNSKSKPLENTCARSIQIPADRSKAAMSKCPLFPMARSVSTYGTLDQEDIGGQKLVPTGSLPTTLQGAADSLGLEWHLPSPDPITVPYLSPLVVWKELESLLENEGDRAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKGDNSFNQELLKNMVKSIKMNDVYGPMSQILDTLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1906, "header": "tr|A0AAA9SYJ9-1|A0AAA9SYJ9_BOVIN Computationally mapped isoform of DENN domain containing 4A OS=Bos taurus OX=9913 GN=DENND4A PE=4 SV=1 CANONICAL=A0AAA9ST20-1" }, "locus": { "chromosome": "10", "start_pos": 12638806, "end_pos": 12556964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131098.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131098.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089332.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089332.1" } ] } }, { "isoform_ac": "E1BJE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20/entry#E1BJE1-1", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVARPKEPITDVSVIIKSLGEEVPRDYTCIDITPTGLSADLNNGSLVGPQIFLCYRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRFLLGLASSANEKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLCFMASILKGYRSYLRPITQAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQTRKSKLPSKSSSPSSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVAQFKRALKKHANLSQTALSADGSDLDAVSHGSMDSGHGTHAVEQAPCSTGSIKAYASDDRSSTGGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDSSSLSECESAKGSADCLPKLGYQSSSSIVRLNGTSNSADKISGESTESTSEPLLISSFEDANETGNIQSRCFRKRHKSDNEPDLQQQMSWVNRSRNLSGGVLMGLMLSRINQEANPGNMVEKLGADAKILSNVISKSTRPNSLNIGKPSLRSKRDSVEKESSDDDTPFDGSNCLTDKVDSPVIFDLEDLDNETDISKARYIVPQNPKRSQRLNSSFSIKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEEEDDSKSVSTPSARRDLAEEIEMYMNNMSSPLTSRTPSIDLQRACDDKVTTKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYSKNEDRPRDRLWSSPAFSPTCPFREESQDALTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSQESSATSGTKGVDFSRTSLEGSASLEGSLSKFALPGKSEVASSCNTSNTNIFQNYAMEVLISSCSRCKTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNIEIRDLRRPGRYFLKSSPSTENIHFPSSFSSQTRQSCISTSTSGLDTSLLSVHGSFDLNSKSKPLENTCARSIQIPADRSKAAMSKCPLFPMARSVSTYGTLDQEDIGGQKLVPTGSLPTTLQGAADSLGLEWHLPSPDPITVPYLSPLVVWKELESLLENEGDRAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKGDNSFNQELLKNMVKSIKMNDVYGPMSQILDTLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1907, "header": "tr|E1BJE1-1|A0AAA9ST20_BOVIN Computationally mapped isoform of DENN domain containing 4A OS=Bos taurus OX=9913 GN=DENND4A PE=4 SV=4 CANONICAL=A0AAA9ST20-1" }, "locus": { "chromosome": "10", "start_pos": 12638806, "end_pos": 12556964, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022733.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022733.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022733.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022733.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1677, "start_aa": "Thr", "end_pos": 1677, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1677", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 679, "start_aa": "Thr", "end_pos": 679, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr679", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514906", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514906", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z3U9-1", "protein_name": "DENN domain containing 4A", "gene_name": "DENND4A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEDKGARVADYFVVAGLTDISKPLEEEIHFNDACHKIAKPKEPITDVTVIIKSLGEEVPQGYKCIDVTPSGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDGKERVKQGCEIIQATPYGRPANISGNASSQRVFITYRRASENMTQNTLAVTDICIIIPSKGETPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPEEDYESFPLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYPEENLTEKQKSQLGLAAVEGKSDSCRTVQTNKCICLLSHWPFFDAFKKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPYDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYIPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKAIAWKILPKKPCKNLMNTLNNLYQQLAVQQRPREDALMELAMNDYDFNSGKKLHLLDLEIQEAFLCFMASILKGYRSYLRPITEAPSETATDASSLFELQGFLKSRDRSHQKFYTLMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDTDKTGETRLIELDESYKSEHTVFITPPEIPHLPNGEEHPLQYSYNGFPVLKLELFERPEGLLTIPNNKLSSKASSPNSPSPMFRRTKQEIKSAHKIAKKYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALRTAYDVLQKMHTKKIDPPDEVCYRVLMQLCGQYGQPVLAVRVLFEMQKAGVDPNAITYGYYNKAVLESTWPSSNRGGYFLWMKIRNVVLGIAQFKRALKKLPTSSSHTALPGGLSDLGSNTSFKDETRQGKTCLQDIQEQKEDKRESDSSSLSEVESAKGSGDCLPKLNYHNSNNDKGTSSIVRLNGTIDNTVAEASTESSVGLLFTSSFDDANEAEVIKSKSLRRRHKSAAEPDVREIPWESRNRNLSGDGLVGLMINRINQEANPGEMVEKLGADAKILSSALQKSIRPKTLNIRSSSLGSKRESLEKESSDEDAAFDCSFTDKTESPVIFDLEDLDAEPETSTTVKTSSEKSRRLQRKSSFPVKPVEKTDVETGFDPLSLLVAETEQQKEDEEEDDDRSASTPSARRDLAEEIVMYMNNMSSPLSSRAPSIELQKPFDDRNVNKKSPTVIQACRRSSLPPNSPRPSSLIKSKSYHSKAEERSRDRLWSSPAYSPHSPAKEQEGTGALPLVSSPSFNLDTLLTPKFDVLKSSMFSAGKGVAEKASKWYSKFAMYAASSKDQNSDRASVSSLGALDSESTSLTDEDVCNDFESTSPQENATSEIKGIGLSRTSLESSASHDGSSKQFDQCGSLSKFPLPDKSELISSCSTSSTSVFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLSIEIRDLRRPGRYFLKSSPSTENMQFPSLYSNPNGKSCNTAATAGLTTSLMSVQEDIHSDSNSKQSDNTCARSIQIPSGRRQNTSGSECTSHPVARSISTFGPLEEDEKESQKINHIIPTGSLPATLQGPTDPLGLDWRLPSPDPITVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKNSKIPRNCMSEDSKYVLIQMLWDNMKLHQDPRQPLYILWNAQSQNRTLLFETQKYPMVHLLQKDDDSFNQELLRSMVKSIKMNDVYGPMSQILERLNKWPHIKRQRSLYREILFLSLVALGRDNIDIDAFDREYKMAYDRLTANQVKNTHNCDRPPSTGVMECRKIFGEPYL", "length": 1883 }, "evidence": [ { "id": "A0AAA9ST20", "url": "https://omabrowser.org/oma/group/A0AAA9ST20/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A518-1", "protein_name": "DENN domain containing 4A", "gene_name": "Dennd4a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDISKPLEEEIHFNDACHKVARPKEPITDVSVIIKSLGEEVPQDYVCIDVTPTGLSADLNNGSLVGPQIYLCYKRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENTTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPPDSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSLVDGKSDGSRTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHALPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLHNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITEAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDTDKSGEVRLIELDASFKSEHTVFVTPPEIPQLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQARKNKLPSKPSSPGSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQLKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKIRNVVLGVAQFKRALKKHPHLPQTALSGGRSDLGYSSLCKDDVRREATSTEDIQGEKDKKGSDSSSLSENESAKGSADCLPSLSYQSSSTIVRLSGTNQDGADKMSGECEESTPELLLVPSCNDTNEAQTMPSRCFRKRHKSDDESHLQQQMPWGNRNRNLSGGVLMRFMLNRINQETNPGDMVEKLGADAKILSNVISKSTRPNSLDIGKPPVRSKRDSLEKESSDDDTPFDASNCLDKVESPVIFDLEDLDTETDGSKVGCVAAQNPKRLQRMNSSFSVKPSEKTDVVTGFDPLSLLVAETEQQQKVEEEDDEDDNKSISTPSARRNLAEEIEMYMNNMSSPLTSRTPSIDLQRASDEKLTNKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYTKSEERPRDRLWSSPAFSPTCPFREGSQETLAHSSPSFNLDTLLVPKLDVLRHSVFTAGKGVAEKASKWYSRFAMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSSQESSAASGTKGIDASRASLGSSASLEGSLSKFALPGKTETASSLNTSNTNIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNVEIRDLRRPGRYFLKSSSSTETMHFASSFSSRTRQSCISASASGLDTSSLSVQGNLDLNNKSKLQENPCARSIQIPAHRSKTVVSKCPLFPMARSISTCGPLDKDEPGGQKLIPTGSLPATLQGPTDSLGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHSQNRTLLFETQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLSKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1873 }, "evidence": [ { "id": "A0AAA9ST20", "url": "https://omabrowser.org/oma/group/A0AAA9ST20/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q8V6-1", "protein_name": "DENN domain containing 4A", "gene_name": "Dennd4a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDISKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVPRDYVCIDVTPTGLSADLNNGSLVGPQIYLCYKRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENTTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLSNSMWGSAVYLCYKKSVAKTNTISYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPPDSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYPEENLTEKQRLLLGLTSLVDGKSDSTRTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHALPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDLDTNTISQTGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAMNDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDATSLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDTDKSGEVRLIELDASFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQARKNKLPSKPSSPGSPSPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQLKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVAQFKRALKKHPHLPQTALSGGRSDLGYNSLSKDNVRREGPSTEDIQGEKEKRGSDSSSLSENESTKGSAECLPTLSYQRASTIVRLNGAHNDSAGKTSGECEESTPELLLMPSLEDTNEAQTTPSRCFRKRHKSDDGSHLQQQMPWGSRNRNLSGGVLMGFMLNRTNQETSPGEMVEKLGADAKILSNVISKSTRPNSLDIGKPPARSKRDSLEKESSDDDTPFHGSNCLDKVESPVIFDLEDLDTETDGSKVGGVAAQNPKRLQRRNSSFSVKPSEKTDVVTGFDPLSLLVAETEQQQKVEEEEDEDDNKSVSTPSARRNLAEEIEMYMNNMSSPLTSRTPSIDLQRACDDKLTNKKSPTLVKACRRSSLPPNSPRPVRLTKSKSYTKSEERPRDRLWSSPAFSPTCPFREGSQETLAHSSPSFNLDTLLVPKLDVLRHSVFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGATSSQESSAASGTKGIDVSRASLGSSASLEGSLSKFALPGKSETASSLNTSNANIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNLFLPFLNVEIRDLRRPGRYFLKSSSSTETMHFASRTRQSCISASASGLDTSSLSVQGNFDLNNKSKLQENPCARSIQIPAHRSKTVVSKCPLFPMARSISTCGPLDKDDPGGQKLIPTGSLPATLQGHTDSLGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHSQNRTLLFETQKYPMVHLLQKGDDSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1869 }, "evidence": [ { "id": "A0AAA9ST20", "url": "https://omabrowser.org/oma/group/A0AAA9ST20/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z401-1", "protein_name": "C-myc promoter-binding protein", "gene_name": "DENND4A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVPQDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVDKNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLSGGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL", "length": 1863 }, "evidence": [ { "id": "A0AAA9ST20", "url": "https://omabrowser.org/oma/group/A0AAA9ST20/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of Rab protein signal transduction", "id": "GO:0032483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032483", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1012, "end_pos": 1014, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1042, "end_pos": 1044, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1072, "end_pos": 1074, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1076, "end_pos": 1078, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1171, "end_pos": 1173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1193, "end_pos": 1195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1257, "end_pos": 1259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1474, "end_pos": 1476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1520, "end_pos": 1522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1788, "end_pos": 1790, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" }, { "start_pos": 894, "end_pos": 896, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" }, { "id": "PS51498", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51498" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MABP", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 200, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9ST20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST20" }, { "id": "PS50211", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UDENN", "eco_id": "ECO_0000259", "start_pos": 192, "end_pos": 642, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 679, 1677 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1012, "end_pos": 1014 }, { "start_pos": 1042, "end_pos": 1044 }, { "start_pos": 1072, "end_pos": 1074 }, { "start_pos": 1076, "end_pos": 1078 }, { "start_pos": 1171, "end_pos": 1173 }, { "start_pos": 1193, "end_pos": 1195 }, { "start_pos": 1257, "end_pos": 1259 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 1474, "end_pos": 1476 }, { "start_pos": 150, "end_pos": 152 }, { "start_pos": 1520, "end_pos": 1522 }, { "start_pos": 1788, "end_pos": 1790 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 79, "end_pos": 81 }, { "start_pos": 894, "end_pos": 896 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVW3-1", "uniprot_ac": "A0AAA9SVW3", "uniprot_id": "A0AAA9SVW3_BOVIN", "mass": { "chemical_mass": 22127.0, "monoisotopic_mass": 22127.0 }, "refseq": { "ac": "NP_001137559", "name": "coiled-coil domain-containing protein 85B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137559" }, "gene_names": [ { "name": "CCDC85B", "type": "recommended", "evidence": [ { "id": "A0AAA9SVW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ] }, { "name": "CCDC85B", "type": "synonym", "evidence": [ { "id": "NP_001137559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137559" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 85B", "type": "synonym", "evidence": [ { "id": "A0AAA9SVW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 85B", "type": "synonym", "evidence": [ { "id": "NP_001137559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137559" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC85B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3", "locus": { "chromosome": "29", "start_pos": 44011246, "end_pos": 44005086, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062229", "url": "https://www.ensembl.org/id/ENSBTAG00000062229" } ] } } ], "crossref": [ { "id": "A0AAA9SVW3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "540332", "url": "https://www.ncbi.nlm.nih.gov/gene/540332", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540332", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540332", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13546", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13546", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13546:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13546:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001137559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137559", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAETGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGSGGSGGSGAGPTPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD", "length": 202, "header": "tr|A0AAA9SVW3-1|A0AAA9SVW3_BOVIN Isoform 1 of Coiled-coil domain containing 85B OS=Bos taurus OX=9913 GN=CCDC85B PE=3 SV=1 CANONICAL=A0AAA9SVW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3/entry#A0AAA9SRX8-1", "sequence": { "sequence": "MEAETGGLEELTDEEMAALGKEELVRRLRREEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGSGGSGGSGAGPTPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD", "length": 186, "header": "tr|A0AAA9SRX8-1|A0AAA9SVW3_BOVIN Computationally mapped isoform of Coiled-coil domain containing 85B OS=Bos taurus OX=9913 GN=CCDC85B PE=3 SV=1 CANONICAL=A0AAA9SVW3-1" }, "locus": { "chromosome": "29", "start_pos": 44006620, "end_pos": 44006015, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116236.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116236.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086713.1" } ] } }, { "isoform_ac": "A0AAA9SVW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3/entry#A0AAA9SVW3-1", "sequence": { "sequence": "MEAETGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGSGGSGGSGAGPTPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD", "length": 202, "header": "tr|A0AAA9SVW3-1|A0AAA9SVW3_BOVIN Isoform 1 of Coiled-coil domain containing 85B OS=Bos taurus OX=9913 GN=CCDC85B PE=3 SV=1 CANONICAL=A0AAA9SVW3-1" }, "locus": { "chromosome": "29", "start_pos": 44012106, "end_pos": 44011246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135778.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135778.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088158.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088158.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 165, "start_aa": "Thr", "end_pos": 165, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr165", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540332", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540332", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" }, { "name": "negative regulation of fat cell differentiation", "id": "GO:0045599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045599", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "delta-catenin binding", "id": "GO:0070097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070097", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 165 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS54-1", "uniprot_ac": "A0AAA9SS54", "uniprot_id": "A0AAA9SS54_BOVIN", "mass": { "chemical_mass": 55479.0, "monoisotopic_mass": 55479.0 }, "refseq": { "ac": "XP_010805594", "name": "BTB/POZ domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805594" }, "gene_names": [ { "name": "BTBD2", "type": "recommended", "evidence": [ { "id": "A0AAA9SS54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54" } ] }, { "name": "BTBD2", "type": "synonym", "evidence": [ { "id": "XP_010805594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805594" } ] } ], "protein_names": [ { "name": "BTB domain containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SS54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_010805594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805594" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTBD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54", "locus": { "chromosome": "7", "start_pos": 44279996, "end_pos": 44302294, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016108", "url": "https://www.ensembl.org/id/ENSBTAG00000016108" } ] } } ], "crossref": [ { "id": "A0AAA9SS54", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SS54", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18281", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18281", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18523", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18523", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533435", "url": "https://www.ncbi.nlm.nih.gov/gene/533435", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533435", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533435", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR45774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45774:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45774:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010805594", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805594", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SS54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGGSGGRASCPPGVGPGAGGGPGPSANTAPAPGNAAAAAAAPAPAVPGPPPPVSVSVSGPGAQAAAGGERAAEEPGAAALLREPVYNWQATKPTVKERFAFLFNNEVLCDVHFLVGKGLGAQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFTAVVRWSEAECQRQQLQVTPENKRKVLGKALALIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVDFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT", "length": 519, "header": "tr|A0AAA9SS54-1|A0AAA9SS54_BOVIN Isoform 1 of BTB domain containing 2 OS=Bos taurus OX=9913 GN=BTBD2 PE=4 SV=1 CANONICAL=A0AAA9SS54-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54/entry#A0AAA9SS54-1", "sequence": { "sequence": "MAAGGSGGRASCPPGVGPGAGGGPGPSANTAPAPGNAAAAAAAPAPAVPGPPPPVSVSVSGPGAQAAAGGERAAEEPGAAALLREPVYNWQATKPTVKERFAFLFNNEVLCDVHFLVGKGLGAQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFTAVVRWSEAECQRQQLQVTPENKRKVLGKALALIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVDFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT", "length": 519, "header": "tr|A0AAA9SS54-1|A0AAA9SS54_BOVIN Isoform 1 of BTB domain containing 2 OS=Bos taurus OX=9913 GN=BTBD2 PE=4 SV=1 CANONICAL=A0AAA9SS54-1" }, "locus": { "chromosome": "7", "start_pos": 44302061, "end_pos": 44281000, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130408.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130408.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086934.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086934.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533435", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533435", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SS54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS54" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 181, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 430, "end_pos": 432 }, { "start_pos": 458, "end_pos": 460 }, { "start_pos": 503, "end_pos": 505 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SS72-1", "uniprot_ac": "A0AAA9SS72", "uniprot_id": "A0AAA9SS72_BOVIN", "mass": { "chemical_mass": 5462.0, "monoisotopic_mass": 5462.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SS72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS72/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SS72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS72", "locus": {} } ], "crossref": [ { "id": "A0AAA9SS72", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SS72", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR057129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF23701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SS72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRAGEPTGLVRRESVEEKTQSASWKVRIISATTAWPAVVLLLSCKGMVC", "length": 50, "header": "tr|A0AAA9SS72-1|A0AAA9SS72_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SS72-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS72/entry#A0AAA9SS72-1", "sequence": { "sequence": "MDRAGEPTGLVRRESVEEKTQSASWKVRIISATTAWPAVVLLLSCKGMVC", "length": 50, "header": "tr|A0AAA9SS72-1|A0AAA9SS72_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SS72-1" }, "locus": { "chromosome": "5", "start_pos": 29911520, "end_pos": 29911371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136033.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136033.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089234.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSB4-1", "uniprot_ac": "A0AAA9SSB4", "uniprot_id": "A0AAA9SSB4_BOVIN", "mass": { "chemical_mass": 49184.0, "monoisotopic_mass": 49184.0 }, "refseq": { "ac": "XP_005224736", "name": "protein shisa-9 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224736" }, "gene_names": [ { "name": "SHISA9", "type": "recommended", "evidence": [ { "id": "A0AAA9SSB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ] }, { "name": "CKAMP44", "type": "synonym", "evidence": [ { "id": "XP_005224736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224736" } ] }, { "name": "SHISA9", "type": "synonym", "evidence": [ { "id": "XP_005224736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224736" } ] } ], "protein_names": [ { "name": "Shisa family member 9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4/entry#names_and_taxonomy" } ] }, { "name": "protein shisa-9 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005224736", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224736" } ] } ], "function": [ { "annotation": "Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4#function" }, { "database": "UniProtKB", "id": "ARBA00037492", "url": "https://www.uniprot.org/uniprotkb/ARBA00037492#function" }, { "database": "UniProtKB", "id": "G3MXA2", "url": "https://www.uniprot.org/uniprotkb/G3MXA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHISA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4", "locus": { "chromosome": "25", "start_pos": 11983825, "end_pos": 11633245, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046399", "url": "https://www.ensembl.org/id/ENSBTAG00000046399" } ] } } ], "crossref": [ { "id": "A0AAA9SSB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046399", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046399", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100139490", "url": "https://www.ncbi.nlm.nih.gov/gene/100139490", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3MXA2", "url": "https://www.orthodb.org/?gene=G3MXA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31774:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31774:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224736", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224736", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXA2", "url": "https://www.uniprot.org/uniprotkb/G3MXA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXA2-1", "url": "https://www.uniprot.org/uniprotkb/G3MXA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCGPRRLAAPGSSLGSFGRASRGGCSGSSGGRVAEPGLGDTMRRVLRLLLGCFLTELCARVCRAQERAGHGQLAQLGGVVVLTGGNRSGAASGEVGEGVGVSDAPPTRAPTPDFCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHRPQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDTRTPINNLHTTQMNNAVPTSPLLQQMGHPHSYPSLGQISNPYEQQPPGKELNKYASLKAVADKVNDDFYSKRRHLAELAAKGNLPLHPVRVEDEPRAFSPEHGPAKQNGQKSRTNKTPPHPLAYNSTANFKSWDPKDQSLRRQQAYGNKGKLGTAESGSSDPLGTRTPHYPPPQPYFITNSKTEVTV", "length": 450, "header": "tr|A0AAA9SSB4-1|A0AAA9SSB4_BOVIN Isoform 1 of Shisa family member 9 OS=Bos taurus OX=9913 GN=SHISA9 PE=3 SV=1 CANONICAL=A0AAA9SSB4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4/entry#A0AAA9SSB4-1", "sequence": { "sequence": "MCGPRRLAAPGSSLGSFGRASRGGCSGSSGGRVAEPGLGDTMRRVLRLLLGCFLTELCARVCRAQERAGHGQLAQLGGVVVLTGGNRSGAASGEVGEGVGVSDAPPTRAPTPDFCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHRPQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDTRTPINNLHTTQMNNAVPTSPLLQQMGHPHSYPSLGQISNPYEQQPPGKELNKYASLKAVADKVNDDFYSKRRHLAELAAKGNLPLHPVRVEDEPRAFSPEHGPAKQNGQKSRTNKTPPHPLAYNSTANFKSWDPKDQSLRRQQAYGNKGKLGTAESGSSDPLGTRTPHYPPPQPYFITNSKTEVTV", "length": 450, "header": "tr|A0AAA9SSB4-1|A0AAA9SSB4_BOVIN Isoform 1 of Shisa family member 9 OS=Bos taurus OX=9913 GN=SHISA9 PE=3 SV=1 CANONICAL=A0AAA9SSB4-1" }, "locus": { "chromosome": "25", "start_pos": 11982821, "end_pos": 11633304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129003.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129003.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088224.1" } ] } }, { "isoform_ac": "G3MXA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4/entry#G3MXA2-1", "sequence": { "sequence": "MRRVLRLLLGCFLTELCARVCRAQERAGHGQLAQLGGVVVLTGGNRSGAASGEVGEGVGVSDAPPTRAPTPDFCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTCTNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHRPQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDTRTPINNLHTTQMNNAVPTSPLLQQMGHPHSYPSLGQISNPYEQQPPGKELNKYASLKAVGSSEGDWTVATLKSPKADKVNDDFYSKRRHLAELAAKGNLPLHPVRVEDEPRAFSPEHGPAKQNGQKSRTNKTPPHPLAYNSTANFKSWDPKDQSLRRQQAYGNKGKLGTAESGSSDPLGTRTPHYPPPQPYFITNSKTEVTV", "length": 425, "header": "tr|G3MXA2-1|G3MXA2_BOVIN Computationally mapped isoform of Shisa family member 9 OS=Bos taurus OX=9913 GN=SHISA9 PE=3 SV=3 CANONICAL=A0AAA9SSB4-1" }, "locus": { "chromosome": "25", "start_pos": 11982821, "end_pos": 11633427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065298.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065298.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054165.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054165.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "pmid": "" }, { "name": "AMPA glutamate receptor complex", "id": "GO:0032281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "pmid": "" }, { "name": "dendritic spine membrane", "id": "GO:0032591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of short-term neuronal synaptic plasticity", "id": "GO:0048172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048172", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB4" }, { "id": "PF13908", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shisa N-terminal", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 163, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 157, "end_pos": 159 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSB6-1", "uniprot_ac": "A0AAA9SSB6", "uniprot_id": "A0AAA9SSB6_BOVIN", "mass": { "chemical_mass": 10871.0, "monoisotopic_mass": 10871.0 }, "refseq": { "ac": "XP_024838948", "name": "serine protease inhibitor Kazal-type 8 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838948" }, "gene_names": [ { "name": "SPINK8", "type": "recommended", "evidence": [ { "id": "A0AAA9SSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6" } ] }, { "name": "SPINK8", "type": "synonym", "evidence": [ { "id": "XP_024838948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838948" } ] } ], "protein_names": [ { "name": "Serine peptidase inhibitor Kazal type 8 (putative)", "type": "synonym", "evidence": [ { "id": "A0AAA9SSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6/entry#names_and_taxonomy" } ] }, { "name": "serine protease inhibitor Kazal-type 8 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024838948", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838948" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPINK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6", "locus": { "chromosome": "22", "start_pos": 51553416, "end_pos": 51540625, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066275", "url": "https://www.ensembl.org/id/ENSBTAG00000066275" } ] } } ], "crossref": [ { "id": "A0AAA9SSB6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "112443439", "url": "https://www.ncbi.nlm.nih.gov/gene/112443439", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21312", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21312", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21312:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21312:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00050", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00050", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838948", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838948", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGVFPSAILLLVLSMWAAFAVDFPLPMDRGTDLEKTKAECTKNMNKCWILAYLRPTDSICGSDHITYSGECHLCYRILYEKLNIIKLHDGPCENS", "length": 96, "header": "tr|A0AAA9SSB6-1|A0AAA9SSB6_BOVIN Isoform 1 of Serine peptidase inhibitor Kazal type 8 (putative) OS=Bos taurus OX=9913 GN=SPINK8 PE=4 SV=1 CANONICAL=A0AAA9SSB6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6/entry#A0AAA9SSB6-1", "sequence": { "sequence": "MKGVFPSAILLLVLSMWAAFAVDFPLPMDRGTDLEKTKAECTKNMNKCWILAYLRPTDSICGSDHITYSGECHLCYRILYEKLNIIKLHDGPCENS", "length": 96, "header": "tr|A0AAA9SSB6-1|A0AAA9SSB6_BOVIN Isoform 1 of Serine peptidase inhibitor Kazal type 8 (putative) OS=Bos taurus OX=9913 GN=SPINK8 PE=4 SV=1 CANONICAL=A0AAA9SSB6-1" }, "locus": { "chromosome": "22", "start_pos": 51553413, "end_pos": 51540625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091857.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091857.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086874.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB6" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 95, "start_aa": "Glu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSD4-1", "uniprot_ac": "A0AAA9SSD4", "uniprot_id": "A0AAA9SSD4_BOVIN", "mass": { "chemical_mass": 91622.0, "monoisotopic_mass": 91622.0 }, "refseq": { "ac": "XP_015317313", "name": "neuroligin-4, X-linked isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317313" }, "gene_names": [ { "name": "LOC100300059", "type": "recommended", "evidence": [ { "id": "A0AAA9SSD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" } ] }, { "name": "LOC100300059", "type": "synonym", "evidence": [ { "id": "XP_015317313", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317313" } ] } ], "protein_names": [ { "name": "Carboxylesterase type B domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SSD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4/entry#names_and_taxonomy" } ] }, { "name": "neuroligin-4, X-linked isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015317313", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317313" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100300059", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SSD4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSD4", "database": "AlphaFoldDB", "categories": [] }, { "id": "100300059", "url": "https://www.ncbi.nlm.nih.gov/gene/100300059", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100300059", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300059", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR43903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00135", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00135", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015317313", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317313", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRPQGLLWLPLAFTPVCVMVNSNVLLWITALAVKFTVIDSQAQYPVVSTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGVRNATQFAAVCPQHLDERSLLHDMLPVWFTANLDTLMTYMQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYRELIQQTITPATYHISFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDHEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPSKIWPTTKRPAITPANSNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNAANDIAHIQNEEIMSLQMKQLDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNIPHGHSTTRV", "length": 815, "header": "tr|A0AAA9SSD4-1|A0AAA9SSD4_BOVIN Isoform 1 of Carboxylesterase type B domain-containing protein OS=Bos taurus OX=9913 GN=LOC100300059 PE=3 SV=2 CANONICAL=A0AAA9SSD4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4/entry#A0AAA9SSD4-1", "sequence": { "sequence": "MSRPQGLLWLPLAFTPVCVMVNSNVLLWITALAVKFTVIDSQAQYPVVSTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGVRNATQFAAVCPQHLDERSLLHDMLPVWFTANLDTLMTYMQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYRELIQQTITPATYHISFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDHEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPSKIWPTTKRPAITPANSNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNAANDIAHIQNEEIMSLQMKQLDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNIPHGHSTTRV", "length": 815, "header": "tr|A0AAA9SSD4-1|A0AAA9SSD4_BOVIN Isoform 1 of Carboxylesterase type B domain-containing protein OS=Bos taurus OX=9913 GN=LOC100300059 PE=3 SV=2 CANONICAL=A0AAA9SSD4-1" }, "locus": { "chromosome": "Y", "start_pos": 3719843, "end_pos": 3417824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125933.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125933.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085929.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085929.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100300059", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300059", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" } ], "pmid": "" }, { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "neurexin family protein binding", "id": "GO:0042043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042043", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD4" }, { "id": "PF00135", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00135" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carboxylesterase type B", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 590, "start_aa": "Tyr", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 511, "end_pos": 513 }, { "start_pos": 802, "end_pos": 804 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSD6-1", "uniprot_ac": "A0AAA9SSD6", "uniprot_id": "A0AAA9SSD6_BOVIN", "mass": { "chemical_mass": 36980.0, "monoisotopic_mass": 36980.0 }, "refseq": {}, "gene_names": [ { "name": "BRICD5", "type": "recommended", "evidence": [ { "id": "A0AAA9SSD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6" } ] } ], "protein_names": [ { "name": "BRICHOS domain containing 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SSD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRICD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6", "locus": { "chromosome": "25", "start_pos": 1739106, "end_pos": 1741616, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009945", "url": "https://www.ensembl.org/id/ENSBTAG00000009945" } ] } } ], "crossref": [ { "id": "A0AAA9SSD6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16483", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16483", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SSD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQGSCWAKRPMPARVSAPPTYALLETEAEGSPAGQEEHLSPELLQPLPPLNQPVAWPPLRAPLTPMCLQVETKPCHRHWRAPGLLLLMLALATAAAVAGGLLGFSHSPPQPPLQTLRLSLPSPGVPRSNQTEQVDVAQNVATIWVTPAQSNHSWAVLFDGQSVSGLAGRGRAGGWFRWPCLTCLPAQGCVCYRPSEHRACFLRLMEPQDRETLQLLVNTSQLQAMQSPSQDTHYTQELLAVLGSQEVDPAQVGAPVRHLCAKTPIYWARRAEGKSGQTVRRSLGFLRTVWGQRGKGPLGFTEPPPPGPQRQRLIYLCIDICFPSNICVSVCFYYLPD", "length": 338, "header": "tr|A0AAA9SSD6-1|A0AAA9SSD6_BOVIN Isoform 1 of BRICHOS domain containing 5 OS=Bos taurus OX=9913 GN=BRICD5 PE=4 SV=2 CANONICAL=A0AAA9SSD6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6/entry#A0AAA9SSD6-1", "sequence": { "sequence": "MGQGSCWAKRPMPARVSAPPTYALLETEAEGSPAGQEEHLSPELLQPLPPLNQPVAWPPLRAPLTPMCLQVETKPCHRHWRAPGLLLLMLALATAAAVAGGLLGFSHSPPQPPLQTLRLSLPSPGVPRSNQTEQVDVAQNVATIWVTPAQSNHSWAVLFDGQSVSGLAGRGRAGGWFRWPCLTCLPAQGCVCYRPSEHRACFLRLMEPQDRETLQLLVNTSQLQAMQSPSQDTHYTQELLAVLGSQEVDPAQVGAPVRHLCAKTPIYWARRAEGKSGQTVRRSLGFLRTVWGQRGKGPLGFTEPPPPGPQRQRLIYLCIDICFPSNICVSVCFYYLPD", "length": 338, "header": "tr|A0AAA9SSD6-1|A0AAA9SSD6_BOVIN Isoform 1 of BRICHOS domain containing 5 OS=Bos taurus OX=9913 GN=BRICD5 PE=4 SV=2 CANONICAL=A0AAA9SSD6-1" }, "locus": { "chromosome": "25", "start_pos": 1741537, "end_pos": 1740110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099489.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099489.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087026.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087026.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 147, "start_aa": "Thr", "end_pos": 147, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr147", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSD6" }, { "id": "PS50869", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50869" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRICHOS", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 269, "start_aa": "Gly", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 147 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 152, "end_pos": 154 }, { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSE2-1", "uniprot_ac": "A0AAA9SSE2", "uniprot_id": "A0AAA9SSE2_BOVIN", "mass": { "chemical_mass": 84435.0, "monoisotopic_mass": 84435.0 }, "refseq": { "ac": "XP_059745488", "name": "zinc finger protein 782 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745488" }, "gene_names": [ { "name": "ZNF782", "type": "recommended", "evidence": [ { "id": "A0AAA9SSE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ] }, { "name": "ZNF782", "type": "synonym", "evidence": [ { "id": "XP_059745488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745488" } ] } ], "protein_names": [ { "name": "Zinc finger protein 782", "type": "synonym", "evidence": [ { "id": "A0AAA9SSE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 782 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059745488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745488" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TK98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK98#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2#function" }, { "database": "UniProtKB", "id": "A0AAA9T0D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0D8#function" }, { "database": "UniProtKB", "id": "G3MYG2", "url": "https://www.uniprot.org/uniprotkb/G3MYG2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF782", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2", "locus": { "chromosome": "8", "start_pos": 83427997, "end_pos": 83515844, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008836", "url": "https://www.ensembl.org/id/ENSBTAG00000008836" } ] } } ], "crossref": [ { "id": "A0AAA9SSE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008836", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008836", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616883", "url": "https://www.ncbi.nlm.nih.gov/gene/616883", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616883", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF152", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF152", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059745488", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745488", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0D8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0D8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYG2", "url": "https://www.uniprot.org/uniprotkb/G3MYG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYG2-1", "url": "https://www.uniprot.org/uniprotkb/G3MYG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTLLRSQKSLGKCQLNHNSLLSQKQKMNIIQASVSFKDVTVEFTQEEWHQMDSAQRTLYRDVMLENYSHLVSVGYCFTKPELIFMLEQGEDPWLLEKEFINRSSPEEFQPDELLEESLENQGKHLRQVLFINKSLTMEQEISGKPCTLDINIFPAETIPCKFDTTGSTYLLLSSLAPHCQYSKKTYAPNVCENWLFSIKDGRTNTGENSFVCSKNVKTFGHKDKVIQHQTIQTLQQAFEYNECRKDFLEKTALVMSKSTHPKMKPYEFNKFGENQHEKSTLIVSQSSHPEEKSHYEFNKYECTKNRNNFSRITQKTDIEGKSFSQKLHTKEQEKFYIGVKSFEYGKNFSHNSTLPVHQRIHTIEQTYDYGTCTDALGYQSACNVHKKTQIMLKPCACNECGKSCTKTSCLIQPQKSHMEEKPFECHQCGKAFSEKSRLRKHERTHTGEKPYKCDGCEKAFSAKSGLRIHQRTHTGEKPFECNECGKSFNYKSILIVHQRIHTGERPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCEKAFGQKSQLRGHHRIHTGEKPYTCNHCGEAFSQKSNLRVHHRTHTGEKPYKCDECGKTFRQKSNLRGHQRTHTGEKPYGCNECAKSFSEKSVLRKHQRTHTGEKPYNCNHCGEAFSQKSNLRVHQRTHTGEKPYKCDTCGKTFSQKSSLREHQKAHTGK", "length": 729, "header": "tr|A0AAA9SSE2-1|A0AAA9SSE2_BOVIN Isoform 1 of Zinc finger protein 782 OS=Bos taurus OX=9913 GN=ZNF782 PE=3 SV=1 CANONICAL=A0AAA9SSE2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2/entry#A0AAA9SSE2-1", "sequence": { "sequence": "MRTLLRSQKSLGKCQLNHNSLLSQKQKMNIIQASVSFKDVTVEFTQEEWHQMDSAQRTLYRDVMLENYSHLVSVGYCFTKPELIFMLEQGEDPWLLEKEFINRSSPEEFQPDELLEESLENQGKHLRQVLFINKSLTMEQEISGKPCTLDINIFPAETIPCKFDTTGSTYLLLSSLAPHCQYSKKTYAPNVCENWLFSIKDGRTNTGENSFVCSKNVKTFGHKDKVIQHQTIQTLQQAFEYNECRKDFLEKTALVMSKSTHPKMKPYEFNKFGENQHEKSTLIVSQSSHPEEKSHYEFNKYECTKNRNNFSRITQKTDIEGKSFSQKLHTKEQEKFYIGVKSFEYGKNFSHNSTLPVHQRIHTIEQTYDYGTCTDALGYQSACNVHKKTQIMLKPCACNECGKSCTKTSCLIQPQKSHMEEKPFECHQCGKAFSEKSRLRKHERTHTGEKPYKCDGCEKAFSAKSGLRIHQRTHTGEKPFECNECGKSFNYKSILIVHQRIHTGERPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCEKAFGQKSQLRGHHRIHTGEKPYTCNHCGEAFSQKSNLRVHHRTHTGEKPYKCDECGKTFRQKSNLRGHQRTHTGEKPYGCNECAKSFSEKSVLRKHQRTHTGEKPYNCNHCGEAFSQKSNLRVHQRTHTGEKPYKCDTCGKTFSQKSSLREHQKAHTGK", "length": 729, "header": "tr|A0AAA9SSE2-1|A0AAA9SSE2_BOVIN Isoform 1 of Zinc finger protein 782 OS=Bos taurus OX=9913 GN=ZNF782 PE=3 SV=1 CANONICAL=A0AAA9SSE2-1" }, "locus": { "chromosome": "8", "start_pos": 83515412, "end_pos": 83429001, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115056.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115056.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085939.1" } ] } }, { "isoform_ac": "A0AAA9T0D8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2/entry#A0AAA9T0D8-1", "sequence": { "sequence": "MASVSFKDVTVEFTQEEWHQMDSAQRTLYRDVMLENYSHLVSVGYCFTKPELIFMLEQGEDPWLLEKEFINRSSPEEFQPDELLEESLENQGKHLRQVLFINKSLTMEQEISGKPCTLDINIFPAETIPCKFDTTGSTYLLLSSLAPHCQYSKKTYAPNVCENWLFSIKDGRTNTGENSFVCSKNVKTFGHKDKVIQHQTIQTLQQAFEYNECRKDFLEKTALVMSKSTHPKMKPYEFNKFGENQHEKSTLIVSQSSHPEEKSHYEFNKYECTKNRNNFSRITQKTDIEGKSFSQKLHTKEQEKFYIGVKSFEYGKNFSHNSTLPVHQRIHTIEQTYDYGTCTDALGYQSACNVHKKTQIMLKPCACNECGKSCTKTSCLIQPQKSHMEEKPFECHQCGKAFSEKSRLRKHERTHTGEKPYKCDGCEKAFSAKSGLRIHQRTHTGEKPFECNECGKSFNYKSILIVHQRIHTGERPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCEKAFGQKSQLRGHHRIHTGEKPYTCNHCGEAFSQKSNLRVHHRTHTGEKPYKCDECGKTFRQKSNLRGHQRTHTGEKPYGCNECAKSFSEKSVLRKHQRTHTGEKPYNCNHCGEAFSQKSNLRVHQRTHTGEKPYKCDTCGKTFSQKSSLREHQKAHT", "length": 696, "header": "tr|A0AAA9T0D8-1|A0AAA9T0D8_BOVIN Computationally mapped isoform of Zinc finger protein 782 OS=Bos taurus OX=9913 GN=ZNF782 PE=3 SV=2 CANONICAL=A0AAA9SSE2-1" }, "locus": { "chromosome": "8", "start_pos": 83505997, "end_pos": 83429007, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126893.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126893.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089982.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089982.2" } ] } }, { "isoform_ac": "A0AAA9TK98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2/entry#A0AAA9TK98-1", "sequence": { "sequence": "MRTLLRSQKSLGKCQASVSFKDVTVEFTQEEWHQMDSAQRTLYRDVMLENYSHLVSVGYCFTKPELIFMLEQGEDPWLLEKEFINRSSPEEFQPDELLEESLENQGKHLRQVLFINKSLTMEQEISGKPCTLDINIFPAETIPCKFDTTGSTYLLLSSLAPHCQYSKKTYAPNVCENWLFSIKDGRTNTGENSFVCSKNVKTFGHKDKVIQHQTIQTLQQAFEYNECRKDFLEKTALVMSKSTHPKMKPYEFNKFGENQHEKSTLIVSQSSHPEEKSHYEFNKYECTKNRNNFSRITQKTDIEGKSFSQKLHTKEQEKFYIGVKSFEYGKNFSHNSTLPVHQRIHTIEQTYDYGTCTDALGYQSACNVHKKTQIMLKPCACNECGKSCTKTSCLIQPQKSHMEEKPFECHQCGKAFSEKSRLRKHERTHTGEKPYKCDGCEKAFSAKSGLRIHQRTHTGEKPFECNECGKSFNYKSILIVHQRIHTGERPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCEKAFGQKSQLRGHHRIHTGEKPYTCNHCGEAFSQKSNLRVHHRTHTGEKPYKCDECGKTFRQKSNLRGHQRTHTGEKPYGCNECAKSFSEKSVLRKHQRTHTGEKPYNCNHCGEAFSQKSNLRVHQRTHTGEKPYKCDTCGKTFSQKSSLREHQKAHTGK", "length": 712, "header": "tr|A0AAA9TK98-1|A0AAA9TK98_BOVIN Computationally mapped isoform of Zinc finger protein 782 OS=Bos taurus OX=9913 GN=ZNF782 PE=3 SV=1 CANONICAL=A0AAA9SSE2-1" }, "locus": { "chromosome": "8", "start_pos": 83515412, "end_pos": 83429001, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115854.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115854.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098799.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098799.1" } ] } }, { "isoform_ac": "G3MYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2/entry#G3MYG2-1", "sequence": { "sequence": "MNIIQASVSFKDVTVEFTQEEWHQMDSAQRTLYRDVMLENYSHLVSVGYCFTKPELIFMLEQGEDPWLLEKEFINRSSPEEFQPDELLEESLENQGKHLRQVLFINKSLTMEQEISGKPCTLDINIFPAETIPCKFDTTGSTYLLLSSLAPHCQYSKKTYAPNVCENWLFSIKDGRTNTGENSFVCSKNVKTFGHKDKVIQHQTIQTLQQAFEYNECRKDFLEKTALVMSKSTHPKMKPYEFNKFGENQHEKSTLIVSQSSHPEEKSHYEFNKYECTKNRNNFSRITQKTDIEGKSFSQKLHTKEQEKFYIGVKSFEYGKNFSHNSTLPVHQRIHTIEQTYDYGTCTDALGYQSACNVHKKTQIMLKPCACNECGKSCTKTSCLIQPQKSHMEEKPFECHQCGKAFSEKSRLRKHERTHTGEKPYKCDGCEKAFSAKSGLRIHQRTHTGEKPFECNECGKSFNYKSILIVHQRIHTGERPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCEKAFGQKSQLRGHHRIHTGEKPYTCNHCGEAFSQKSNLRVHHRTHTGEKPYKCDECGKTFRQKSNLRGHQRTHTGEKPYGCNECAKSFSEKSVLRKHQRTHTGEKPYNCNHCGEAFSQKSNLRVHQRTHTGEKPYKCDTCGKTFSQKSSLREHQKAHTGK", "length": 702, "header": "tr|G3MYG2-1|G3MYG2_BOVIN Computationally mapped isoform of Zinc finger protein 782 OS=Bos taurus OX=9913 GN=ZNF782 PE=3 SV=3 CANONICAL=A0AAA9SSE2-1" }, "locus": { "chromosome": "8", "start_pos": 83513506, "end_pos": 83429001, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064954.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064954.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054594.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054594.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616883", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 396, "end_pos": 423, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SSE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSE2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 106, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 133, "end_pos": 135 }, { "start_pos": 309, "end_pos": 311 }, { "start_pos": 348, "end_pos": 350 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSG4-1", "uniprot_ac": "A0AAA9SSG4", "uniprot_id": "A0AAA9SSG4_BOVIN", "mass": { "chemical_mass": 78871.0, "monoisotopic_mass": 78871.0 }, "refseq": { "ac": "XP_024834989", "name": "outer dynein arm-docking complex subunit 1 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834989" }, "gene_names": [ { "name": "ODAD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SSG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4" } ] }, { "name": "ODAD1", "type": "synonym", "evidence": [ { "id": "XP_024834989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834989" } ] } ], "protein_names": [ { "name": "Outer dynein arm docking complex subunit 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SSG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4/entry#names_and_taxonomy" } ] }, { "name": "outer dynein arm-docking complex subunit 1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024834989", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834989" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ODAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4", "locus": { "chromosome": "18", "start_pos": 55007353, "end_pos": 55036188, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030667", "url": "https://www.ensembl.org/id/ENSBTAG00000030667" } ] } } ], "crossref": [ { "id": "A0AAA9SSG4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "617306", "url": "https://www.ncbi.nlm.nih.gov/gene/617306", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR049258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21694", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21694", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21694:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21694:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834989", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834989", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZE85", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZE85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZE85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFGLSAGSTRSEDGSEAFLEGMVDWELSRLQRQCKVMEDERRAYSKEVHQRINKQLEEIQRLEGVRHKLRVQISIAQSQVRRLRDSERLESMGHLLKCQVRVQAEVKELQAQNQALDREIQEWESRNSAHSKNARSPGCVQHDKVKSQRRIKSLENQLDKVICRFDIQLAQNATLREELDLLRIERNRYLNVDRKLQKEIQLLKDSVRNLMVSSTSAYTVREEAKAKLGMLRERAEKEVAQNETEVQILQRQIAHLEQLHHFLKLKNGDRQPDSAIVEKREQRAREVAEGLRKTSQEKLVLRYEDALNKLSQMTGESDPDLLVEKYLELEERNFAEFNFINEQNSELEHLQEEIKEMQEALVSGRRSEEDRRAQQEQQRAELQQRVDDVHSEADDLEARYHNFREQLEKLKTNIQHLFTRAQCDSTLINDLLGIKTHMRDRDISLFLSLIEKRLVQLLTVQAFLETQNYTSTSMFNAALMVLGQSSEDFPKKVAPPQPPDNLEDPPGFEAKDDYPLSKEELLSSVMKALEAREQPKEQHLKELVESIKVESTPSMTSSTQKVSSSSRLVTQRPSQVPGSIMSHRTSGILVSSGGRATSSNVGHVTFGDSSATTGGLMSSRGSIPGRVTFRSPNSSSYLGSTGYVGSSRDHDSFEASKGPGSESSGGLGSSPGPASSPGPASSTGQASSTSKDSQSNY", "length": 698, "header": "tr|A0AAA9SSG4-1|A0AAA9SSG4_BOVIN Isoform 1 of Outer dynein arm docking complex subunit 1 OS=Bos taurus OX=9913 GN=ODAD1 PE=4 SV=1 CANONICAL=A0AAA9SSG4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4/entry#A0AAA9SSG4-1", "sequence": { "sequence": "MPFGLSAGSTRSEDGSEAFLEGMVDWELSRLQRQCKVMEDERRAYSKEVHQRINKQLEEIQRLEGVRHKLRVQISIAQSQVRRLRDSERLESMGHLLKCQVRVQAEVKELQAQNQALDREIQEWESRNSAHSKNARSPGCVQHDKVKSQRRIKSLENQLDKVICRFDIQLAQNATLREELDLLRIERNRYLNVDRKLQKEIQLLKDSVRNLMVSSTSAYTVREEAKAKLGMLRERAEKEVAQNETEVQILQRQIAHLEQLHHFLKLKNGDRQPDSAIVEKREQRAREVAEGLRKTSQEKLVLRYEDALNKLSQMTGESDPDLLVEKYLELEERNFAEFNFINEQNSELEHLQEEIKEMQEALVSGRRSEEDRRAQQEQQRAELQQRVDDVHSEADDLEARYHNFREQLEKLKTNIQHLFTRAQCDSTLINDLLGIKTHMRDRDISLFLSLIEKRLVQLLTVQAFLETQNYTSTSMFNAALMVLGQSSEDFPKKVAPPQPPDNLEDPPGFEAKDDYPLSKEELLSSVMKALEAREQPKEQHLKELVESIKVESTPSMTSSTQKVSSSSRLVTQRPSQVPGSIMSHRTSGILVSSGGRATSSNVGHVTFGDSSATTGGLMSSRGSIPGRVTFRSPNSSSYLGSTGYVGSSRDHDSFEASKGPGSESSGGLGSSPGPASSPGPASSTGQASSTSKDSQSNY", "length": 698, "header": "tr|A0AAA9SSG4-1|A0AAA9SSG4_BOVIN Isoform 1 of Outer dynein arm docking complex subunit 1 OS=Bos taurus OX=9913 GN=ODAD1 PE=4 SV=1 CANONICAL=A0AAA9SSG4-1" }, "locus": { "chromosome": "18", "start_pos": 55034574, "end_pos": 55008784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122885.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122885.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088273.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088273.1" } ] } }, { "isoform_ac": "A0AAF6ZE85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4/entry#A0AAF6ZE85-1", "sequence": { "sequence": "MPFGLSAGSTRSEDGSEAFLEGMVDWELSRLQRQCKVMEDERRAYSKEVHQRINKQLEEIQRLEGVRHKLRVQISIAQSQVRRLRDSERLESMGHLLKCQVRVQAEVKELQAQNQALDREIQEWESRNSAHSKNARSPGCVQHDKVKSQRRIKSLENQLDKVICRFDIQLAQNATLREELDLLRIERNRYLNVDRKLQKEIQLLKDSVRNLMVSSTSAYTVREEAKAKLGMLRERAEKEVAQNETEVQILQRQIAHLEQLHHFLKLKNGDRQPDSAIVEKREQRAREVAEGLRKTSQEKLVLRYEDALNKLSQMTGESDPDLLVEKYLELEERNFAEFNFINEQNSELEHLQEEIKEMQEALVSGRRSEEDRRAQQEQQRAELQQRVDDVHSEADDLEARYHNFREQLEKLKTNIQHLFTRAQCDSTLINDLLGIKTHMRDRDISLFLSLIEKRLVQLLTVQAFLETQNYTSTSMFNAALMVLGQSSEDFPKKVAPPQPPDNLEDPPGFEAKDDYPLSKEELLSSVMKALEAREQPKEQHLKELVESIKVESTPSMTSSTQKVSSSSRLVTQRPSQVPGSIMSHRTSGILVSSGGRATSSNVGHVTFGDSSATTGGLMSSRGSIPGRVTFRSPNSSSYLGSTGYVGSSRDHDSFEVSKERAESSMSTLLPQNCTRKKKIQIASQVFN", "length": 687, "header": "tr|A0AAF6ZE85-1|A0AAF6ZE85_BOVIN Computationally mapped isoform of Outer dynein arm docking complex subunit 1 OS=Bos taurus OX=9913 GN=ODAD1 PE=4 SV=1 CANONICAL=A0AAA9SSG4-1" }, "locus": { "chromosome": "18", "start_pos": 55034574, "end_pos": 55007942, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043347.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043347.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040922.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040922.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" }, { "start_pos": 634, "end_pos": 636, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSG4" }, { "id": "PF21773", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21773" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ODAD1 central coiled coil region", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 434, "start_aa": "Gln", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 469, "end_pos": 471 }, { "start_pos": 634, "end_pos": 636 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSJ2-1", "uniprot_ac": "A0AAA9SSJ2", "uniprot_id": "A0AAA9SSJ2_BOVIN", "mass": { "chemical_mass": 16294.0, "monoisotopic_mass": 16294.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SSJ2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SSJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWTPLLLMFLSHYTGSLSQPVLTQPAVSASLGASARLSCTLSSGYNVSNYSIYWYQQKAGNPLRYLLRFKSDSDKHQGSGVPSRFSGSKDASTNAGLLLISGLQPEDEADYYCAVWHGDTNAYTELQTSEEVRQKPPPLTPARGLDEV", "length": 149, "header": "tr|A0AAA9SSJ2-1|A0AAA9SSJ2_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SSJ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2/entry#A0AAA9SSJ2-1", "sequence": { "sequence": "MAWTPLLLMFLSHYTGSLSQPVLTQPAVSASLGASARLSCTLSSGYNVSNYSIYWYQQKAGNPLRYLLRFKSDSDKHQGSGVPSRFSGSKDASTNAGLLLISGLQPEDEADYYCAVWHGDTNAYTELQTSEEVRQKPPPLTPARGLDEV", "length": 149, "header": "tr|A0AAA9SSJ2-1|A0AAA9SSJ2_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SSJ2-1" }, "locus": { "chromosome": "17", "start_pos": 70716238, "end_pos": 70715672, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094546.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094546.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086963.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 130, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 47, "end_pos": 49 }, { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSJ5-1", "uniprot_ac": "A0AAA9SSJ5", "uniprot_id": "A0AAA9SSJ5_BOVIN", "mass": { "chemical_mass": 35137.0, "monoisotopic_mass": 35137.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SSJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5", "locus": {} } ], "crossref": [ { "id": "A0AAA9SSJ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SSJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VEGLNQTSSVSEFILLGLSSRPEDQKPLFILFLIMYLVTLTGNVLIILAIRSDPQLHTPMYVFLSVLSFTDIWYTTTIVPRMLVDFLSETKTISYAGCLTQMYFIYALSTTDNCLLAAMAYDRYVAICDPFHYVTIMSHCRCVLLVAFSCSLPHLHSLLHILLLNQLTFCDSNVVHHFLCDINPLLKLSCSSIFVNDLTIKTEGLVFWVTPFLCIVFSYVRILMAVLRIPSAAGKRKAFSTCGSHFTVVILFYGSIFYVYLQPLSSYTVQDRVATLVYTVLTSMLNPFIYSLRNKDMKRGLGKLLGRRKS", "length": 310, "header": "tr|A0AAA9SSJ5-1|A0AAA9SSJ5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SSJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5/entry#A0AAA9SSJ5-1", "sequence": { "sequence": "VEGLNQTSSVSEFILLGLSSRPEDQKPLFILFLIMYLVTLTGNVLIILAIRSDPQLHTPMYVFLSVLSFTDIWYTTTIVPRMLVDFLSETKTISYAGCLTQMYFIYALSTTDNCLLAAMAYDRYVAICDPFHYVTIMSHCRCVLLVAFSCSLPHLHSLLHILLLNQLTFCDSNVVHHFLCDINPLLKLSCSSIFVNDLTIKTEGLVFWVTPFLCIVFSYVRILMAVLRIPSAAGKRKAFSTCGSHFTVVILFYGSIFYVYLQPLSSYTVQDRVATLVYTVLTSMLNPFIYSLRNKDMKRGLGKLLGRRKS", "length": 310, "header": "tr|A0AAA9SSJ5-1|A0AAA9SSJ5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SSJ5-1" }, "locus": { "chromosome": "11", "start_pos": 93426117, "end_pos": 93425188, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101256.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101256.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088307.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSJ5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSK3-1", "uniprot_ac": "A0AAA9SSK3", "uniprot_id": "A0AAA9SSK3_BOVIN", "mass": { "chemical_mass": 31778.0, "monoisotopic_mass": 31778.0 }, "refseq": { "ac": "XP_024846753", "name": "homeobox protein DLX-6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846753" }, "gene_names": [ { "name": "DLX6", "type": "recommended", "evidence": [ { "id": "A0AAA9SSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ] }, { "name": "DLX6", "type": "synonym", "evidence": [ { "id": "XP_024846753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846753" } ] } ], "protein_names": [ { "name": "Homeobox protein DLX-6", "type": "recommended", "evidence": [ { "id": "A0AAA9SSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein DLX-6", "type": "synonym", "evidence": [ { "id": "XP_024846753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846753" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DLX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3", "locus": { "chromosome": "4", "start_pos": 14394730, "end_pos": 14388930, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021458", "url": "https://www.ensembl.org/id/ENSBTAG00000021458" } ] } } ], "crossref": [ { "id": "A0AAA9SSK3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021458", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021458", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786461", "url": "https://www.ncbi.nlm.nih.gov/gene/786461", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786461", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786461", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MUL4", "url": "https://www.orthodb.org/?gene=F1MUL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24327", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24327", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24327:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24327:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846753", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846753", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUL4", "url": "https://www.uniprot.org/uniprotkb/F1MUL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUL4-1", "url": "https://www.uniprot.org/uniprotkb/F1MUL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQPPPPPPPPHSQQSSPAMAGAHYPLHCLHSAAAAAAAAGSHHHHHQHHHHGSPYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLPGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM", "length": 287, "header": "tr|A0AAA9SSK3-1|A0AAA9SSK3_BOVIN Isoform 1 of Homeobox protein DLX-6 OS=Bos taurus OX=9913 GN=DLX6 PE=3 SV=1 CANONICAL=A0AAA9SSK3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3/entry#A0AAA9SSK3-1", "sequence": { "sequence": "MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQPPPPPPPPHSQQSSPAMAGAHYPLHCLHSAAAAAAAAGSHHHHHQHHHHGSPYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLPGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM", "length": 287, "header": "tr|A0AAA9SSK3-1|A0AAA9SSK3_BOVIN Isoform 1 of Homeobox protein DLX-6 OS=Bos taurus OX=9913 GN=DLX6 PE=3 SV=1 CANONICAL=A0AAA9SSK3-1" }, "locus": { "chromosome": "4", "start_pos": 14393726, "end_pos": 14389768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097378.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097378.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086004.1" } ] } }, { "isoform_ac": "A0AAA9TIY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3/entry#A0AAA9TIY3-1", "sequence": { "sequence": "MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQPPPPPPPPHSQQSSPAMAGAHYPLHCLHSAAAAAAAAGSHHHHHQHHHHGSPYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTGERPLGQLASPASRLPPTPPARPAHFLNAQASAGPLPQAARRAPGQAWCAPACLAPACRPRRAGPLRAAPDPRLPCGSTRLAPSSPARRSGRASDSAQASLDQLARTALSSPQDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLPGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM", "length": 400, "header": "tr|A0AAA9TIY3-1|A0AAA9TIY3_BOVIN Computationally mapped isoform of Homeobox protein DLX-6 OS=Bos taurus OX=9913 GN=DLX6 PE=3 SV=1 CANONICAL=A0AAA9SSK3-1" }, "locus": { "chromosome": "4", "start_pos": 14393726, "end_pos": 14389768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100084.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100084.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098413.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098413.1" } ] } }, { "isoform_ac": "F1MUL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3/entry#F1MUL4-1", "sequence": { "sequence": "AVCPSAQGAPFTQPPHVILEPESGSESSFFAAAGITRALGTQRDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLPGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM", "length": 191, "header": "tr|F1MUL4-1|F1MUL4_BOVIN Computationally mapped isoform of Homeobox protein DLX-6 OS=Bos taurus OX=9913 GN=DLX6 PE=3 SV=4 CANONICAL=A0AAA9SSK3-1" }, "locus": { "chromosome": "4", "start_pos": 14393726, "end_pos": 14391176, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028605.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028605.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028605.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028605.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786461", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786461", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" }, { "name": "embryonic skeletal system development", "id": "GO:0048706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048706", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSK3" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 219, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSN3-1", "uniprot_ac": "A0AAA9SSN3", "uniprot_id": "A0AAA9SSN3_BOVIN", "mass": { "chemical_mass": 8451.0, "monoisotopic_mass": 8451.0 }, "refseq": {}, "gene_names": [ { "name": "SNURF", "type": "recommended", "evidence": [ { "id": "A0AAA9SSN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3" } ] } ], "protein_names": [ { "name": "SNRPN upstream open reading frame", "type": "synonym", "evidence": [ { "id": "A0AAA9SSN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNURF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3", "locus": { "chromosome": "21", "start_pos": 1947081, "end_pos": 1898573, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060892", "url": "https://www.ensembl.org/id/ENSBTAG00000060892" } ] } } ], "crossref": [ { "id": "A0AAA9SSN3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR009847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14508:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14508:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SSN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLNNQECHVYLRRSQQQQVPVVDFQAELRQAFLAETPRGG", "length": 71, "header": "tr|A0AAA9SSN3-1|A0AAA9SSN3_BOVIN Isoform 1 of SNRPN upstream open reading frame OS=Bos taurus OX=9913 GN=SNURF PE=3 SV=1 CANONICAL=A0AAA9SSN3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3/entry#A0AAA9SSN3-1", "sequence": { "sequence": "MERARDRLHLRRTTEQHVPEVEVQVKRRRTASLNNQECHVYLRRSQQQQVPVVDFQAELRQAFLAETPRGG", "length": 71, "header": "tr|A0AAA9SSN3-1|A0AAA9SSN3_BOVIN Isoform 1 of SNRPN upstream open reading frame OS=Bos taurus OX=9913 GN=SNURF PE=3 SV=1 CANONICAL=A0AAA9SSN3-1" }, "locus": { "chromosome": "21", "start_pos": 1947052, "end_pos": 1937738, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129958.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129958.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087007.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSS4-1", "uniprot_ac": "A0AAA9SSS4", "uniprot_id": "A0AAA9SSS4_BOVIN", "mass": { "chemical_mass": 62203.0, "monoisotopic_mass": 62203.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF677", "type": "recommended", "evidence": [ { "id": "A0AAA9SSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" } ] } ], "protein_names": [ { "name": "Zinc finger protein 677", "type": "synonym", "evidence": [ { "id": "A0AAA9SSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF677", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4", "locus": {} } ], "crossref": [ { "id": "A0AAA9SSS4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF97", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF97", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SSS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VSFQGLFTFKDVAVEFTQEEWECLDPIQRALYRDVMLETYRNLLSLGSYSATFAVKELSSPKEDISKGELCHLMTLEKNETYGIKDFDLKEICENMQESESEWGYDARNDKEVLLTHNKNLSQKEDQDNKSLINFPQSVSVRSNTYEYFTHDKPFIRNLLTMKDNIIIAGHNIKCLDSRTGARLQAQVAELQRFTTEEKMYGGTQLEKSVSNGSSVSSLHQIPPSVETTVLSAQHRKTHTREKSYNCNDCGKAFSKKSNLTNHKRIHSGQKPYRCSDCGKAFNHQSHLIAHQRVHAEEKAYKCGVCGKVFSRNSHLANHQRMHTGEKPYKCNECGKAFTQFSHLSRHQKMHAGEKPHKCNECGKHFTQRSNLMAHQRIHTGEKPFKCNKCDKAFIERSQLWGHERTHTGEKLYKCDECGKALTRHSYLTQHKTIHTGEKPYKCNECGKAYTQFASLTRHLKIHTENKHMPHTYGNAFIQSSKLKQFRQNFCMYSSLTQLMGLYQGGKTHTDAQQTHEKMLSIINHQGNAKHKVNEIPHYS", "length": 540, "header": "tr|A0AAA9SSS4-1|A0AAA9SSS4_BOVIN Isoform 1 of Zinc finger protein 677 OS=Bos taurus OX=9913 GN=ZNF677 PE=3 SV=2 CANONICAL=A0AAA9SSS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4/entry#A0AAA9SSS4-1", "sequence": { "sequence": "VSFQGLFTFKDVAVEFTQEEWECLDPIQRALYRDVMLETYRNLLSLGSYSATFAVKELSSPKEDISKGELCHLMTLEKNETYGIKDFDLKEICENMQESESEWGYDARNDKEVLLTHNKNLSQKEDQDNKSLINFPQSVSVRSNTYEYFTHDKPFIRNLLTMKDNIIIAGHNIKCLDSRTGARLQAQVAELQRFTTEEKMYGGTQLEKSVSNGSSVSSLHQIPPSVETTVLSAQHRKTHTREKSYNCNDCGKAFSKKSNLTNHKRIHSGQKPYRCSDCGKAFNHQSHLIAHQRVHAEEKAYKCGVCGKVFSRNSHLANHQRMHTGEKPYKCNECGKAFTQFSHLSRHQKMHAGEKPHKCNECGKHFTQRSNLMAHQRIHTGEKPFKCNKCDKAFIERSQLWGHERTHTGEKLYKCDECGKALTRHSYLTQHKTIHTGEKPYKCNECGKAYTQFASLTRHLKIHTENKHMPHTYGNAFIQSSKLKQFRQNFCMYSSLTQLMGLYQGGKTHTDAQQTHEKMLSIINHQGNAKHKVNEIPHYS", "length": 540, "header": "tr|A0AAA9SSS4-1|A0AAA9SSS4_BOVIN Isoform 1 of Zinc finger protein 677 OS=Bos taurus OX=9913 GN=ZNF677 PE=3 SV=2 CANONICAL=A0AAA9SSS4-1" }, "locus": { "chromosome": "18", "start_pos": 60082493, "end_pos": 60080074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116614.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116614.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087043.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087043.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 245, "end_pos": 272, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSS4" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 81, "start_aa": "Phe", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 212, "end_pos": 214 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SST3-1", "uniprot_ac": "A0AAA9SST3", "uniprot_id": "A0AAA9SST3_BOVIN", "mass": { "chemical_mass": 35657.0, "monoisotopic_mass": 35657.0 }, "refseq": { "ac": "NP_001377506", "name": "olfactory receptor family 51 subfamily V member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377506" }, "gene_names": [ { "name": "OR51V1", "type": "recommended", "evidence": [ { "id": "A0AAA9SST3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" } ] }, { "name": "OR51V1", "type": "synonym", "evidence": [ { "id": "NP_001377506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377506" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SST3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 51 subfamily V member 1", "type": "synonym", "evidence": [ { "id": "NP_001377506", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377506" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377506" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3", "locus": { "chromosome": "15", "start_pos": 48425135, "end_pos": 48424191, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057416", "url": "https://www.ensembl.org/id/ENSBTAG00000057416" } ] } } ], "crossref": [ { "id": "A0AAA9SST3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SST3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788623", "url": "https://www.ncbi.nlm.nih.gov/gene/788623", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788623", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788623", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377506", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SST3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIALVSPSTNSSSFLLTGFSGLEQQYPWISVPFSTIYAVVLLGNCLVLYVIWTEPSLHQPMFYFLAMLAITDLCMGLSTVNTVLGILLGLIQKISLDSCITQAYFIHGLSFMESSVLLTMAFDRYIAICNPLRYSSILTNSRIIKIGLTILGRSFFFITPPIICLKYFHYCRPHILSHSFCLHQDLLRLACSDIRFNSYYALMLVICTLLLDAVLILFSYVLILKSVLAIASREERHKSFQTCISHVCAVLVFYIPIISLTMVHRFGKHLSPVVHVLMGNIYILFPPLMNPIIYSVKIQQIRSRMLRLFSLKIC", "length": 314, "header": "tr|A0AAA9SST3-1|A0AAA9SST3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51V1 PE=3 SV=1 CANONICAL=A0AAA9SST3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SST3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3/entry#A0AAA9SST3-1", "sequence": { "sequence": "MIALVSPSTNSSSFLLTGFSGLEQQYPWISVPFSTIYAVVLLGNCLVLYVIWTEPSLHQPMFYFLAMLAITDLCMGLSTVNTVLGILLGLIQKISLDSCITQAYFIHGLSFMESSVLLTMAFDRYIAICNPLRYSSILTNSRIIKIGLTILGRSFFFITPPIICLKYFHYCRPHILSHSFCLHQDLLRLACSDIRFNSYYALMLVICTLLLDAVLILFSYVLILKSVLAIASREERHKSFQTCISHVCAVLVFYIPIISLTMVHRFGKHLSPVVHVLMGNIYILFPPLMNPIIYSVKIQQIRSRMLRLFSLKIC", "length": 314, "header": "tr|A0AAA9SST3-1|A0AAA9SST3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51V1 PE=3 SV=1 CANONICAL=A0AAA9SST3-1" }, "locus": { "chromosome": "15", "start_pos": 48425132, "end_pos": 48424191, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108936.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108936.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089457.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089457.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788623", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788623", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SST3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SST3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSU7-1", "uniprot_ac": "A0AAA9SSU7", "uniprot_id": "A0AAA9SSU7_BOVIN", "mass": { "chemical_mass": 93720.0, "monoisotopic_mass": 93720.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Histone-lysine N-methyltransferase PRDM9", "type": "recommended", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.354", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.355", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.359", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.361", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.362", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "PR domain zinc finger protein 9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "PR domain-containing protein 9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "Protein-lysine N-methyltransferase PRDM9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "[histone H3]-lysine36 N-trimethyltransferase PRDM9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "[histone H3]-lysine4 N-trimethyltransferase PRDM9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "[histone H3]-lysine9 N-trimethyltransferase PRDM9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] }, { "name": "[histone H4]-lysine20 N-methyltransferase PRDM9", "type": "synonym", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SSU7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19193", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19193", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21549", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21549", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "51736", "url": "https://www.rhea-db.org/rhea/51736", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "54196", "url": "https://www.rhea-db.org/rhea/54196", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60260", "url": "https://www.rhea-db.org/rhea/60260", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60276", "url": "https://www.rhea-db.org/rhea/60276", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60324", "url": "https://www.rhea-db.org/rhea/60324", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60344", "url": "https://www.rhea-db.org/rhea/60344", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60348", "url": "https://www.rhea-db.org/rhea/60348", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRSWALRRLFSALSFGACHPSTRPLNVGDCRGGARWQGPWSPRSSVCLSVTAGCEGIIKGFRATQPGFMHHGRQVLKSQVDDTEDSDEEWTPRQQGKPSGMAFRGEPSKHPKRLSRGPLNKVSSLKKLPGAAKLLKKSGSKQAQKPVPPPREARTPGKHPRHKVELRRKETEVKRYSVRERKGHVYQEVSEPQDDDYLYCEECQNFFIDSCAAHGPPTFVKDSAVEKGHANRSALTLPPGLSIRPSGIPEAGLGVWNEASDLPLGLHFGPYEGQIIYNEEDSNSGYCWLVTKGRNSYEYVDGKDTSLANWMRYVNCARDDEEQNLVALQYHGQIFYRTCRVVRPGCELLVWYGDEYGEELGIKQDKRGKSKLSAQRAEPKPKIYPCASCCLSFSSQKFLSQHVQRNHPSQILLRPSIGDHLQPEDPCPGSQNQQQRYSDPHSLSDKPEGREPKERPHPLLKGPKLCIRPKRISTASSYPPKGQMGGSEVHERMTEEPSTSQKLNPEDTGKLFMEAGVSGIVRVNYGDHEQGSKDRSSLITHEKIHTGEKPYVCKECGKSFNGRSDLTKHKRTHTGEKPYACGECGRSFSFKKNLITHKRTHTREKPYVCRECGRSFNEKSRLTIHKRTHTGEKPYVCGDCGQSFSLKSVLITHQRTHTGEKPYVCGECGRSFNEKSRLTIHKRTHTGEKPYVCGDCGQSFSLKSVLITHQRTHTGEKPYVCGECGQSFNEKSRLTIHKRTHTGEKPYACGDCGQSFSLKSVLITHQRTHTGEKPYVCGECGQSFNEKSRLTIHKRTHTGEKPYVCGDCGQSFSLKSVLITHQRTHTGEKPYVC", "length": 834, "header": "tr|A0AAA9SSU7-1|A0AAA9SSU7_BOVIN Isoform 1 of Histone-lysine N-methyltransferase PRDM9 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SSU7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7/entry#A0AAA9SSU7-1", "sequence": { "sequence": "MLRSWALRRLFSALSFGACHPSTRPLNVGDCRGGARWQGPWSPRSSVCLSVTAGCEGIIKGFRATQPGFMHHGRQVLKSQVDDTEDSDEEWTPRQQGKPSGMAFRGEPSKHPKRLSRGPLNKVSSLKKLPGAAKLLKKSGSKQAQKPVPPPREARTPGKHPRHKVELRRKETEVKRYSVRERKGHVYQEVSEPQDDDYLYCEECQNFFIDSCAAHGPPTFVKDSAVEKGHANRSALTLPPGLSIRPSGIPEAGLGVWNEASDLPLGLHFGPYEGQIIYNEEDSNSGYCWLVTKGRNSYEYVDGKDTSLANWMRYVNCARDDEEQNLVALQYHGQIFYRTCRVVRPGCELLVWYGDEYGEELGIKQDKRGKSKLSAQRAEPKPKIYPCASCCLSFSSQKFLSQHVQRNHPSQILLRPSIGDHLQPEDPCPGSQNQQQRYSDPHSLSDKPEGREPKERPHPLLKGPKLCIRPKRISTASSYPPKGQMGGSEVHERMTEEPSTSQKLNPEDTGKLFMEAGVSGIVRVNYGDHEQGSKDRSSLITHEKIHTGEKPYVCKECGKSFNGRSDLTKHKRTHTGEKPYACGECGRSFSFKKNLITHKRTHTREKPYVCRECGRSFNEKSRLTIHKRTHTGEKPYVCGDCGQSFSLKSVLITHQRTHTGEKPYVCGECGRSFNEKSRLTIHKRTHTGEKPYVCGDCGQSFSLKSVLITHQRTHTGEKPYVCGECGQSFNEKSRLTIHKRTHTGEKPYACGDCGQSFSLKSVLITHQRTHTGEKPYVCGECGQSFNEKSRLTIHKRTHTGEKPYVCGDCGQSFSLKSVLITHQRTHTGEKPYVC", "length": 834, "header": "tr|A0AAA9SSU7-1|A0AAA9SSU7_BOVIN Isoform 1 of Histone-lysine N-methyltransferase PRDM9 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SSU7-1" }, "locus": { "chromosome": "X", "start_pos": 132868603, "end_pos": 132835760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091068.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091068.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087193.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087193.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "positive regulation of reciprocal meiotic recombination", "id": "GO:0010845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010845", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "homologous recombination", "id": "GO:0035825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035825", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "meiosis I cell cycle process", "id": "GO:0061982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "recombination hotspot binding", "id": "GO:0010844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010844", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "histone H4K20me methyltransferase activity", "id": "GO:0140941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140941", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "histone H4K20 monomethyltransferase activity", "id": "GO:0140944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "histone H3K9 trimethyltransferase activity", "id": "GO:0140949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140949", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "histone H3K36 trimethyltransferase activity", "id": "GO:0140955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" }, { "name": "histone H3K4 trimethyltransferase activity", "id": "GO:0140999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140999", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "51736", "name": "", "equation": "L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2YDJ8-1", "Q0P585-1", "P0DPE2-1", "A4FV98-1", "E1BI64-1", "A5PK19-1", "A6QP81-1", "E1B906-1", "G3X834-1", "F1MDT8-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1", "A0ABI0NZS0-1" ], "evidence": [ { "id": "51736", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51736" } ] }, { "id": "54196", "name": "", "equation": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0DPE2-1", "A4FV98-1", "A5PK19-1", "A6QP81-1", "G3X834-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1" ], "evidence": [ { "id": "54196", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54196" } ] }, { "id": "60260", "name": "", "equation": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MZS3-1", "A0AAA9TB51-1", "Q0P585-1", "G3X834-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1" ], "evidence": [ { "id": "60260", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60260" } ] }, { "id": "60276", "name": "", "equation": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X834-1", "A0A3Q1LVN6-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1" ], "evidence": [ { "id": "60276", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60276" } ] }, { "id": "60324", "name": "", "equation": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MDT8-1", "A0A3S5ZPV5-1", "E1BGA4-1", "G3X834-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1" ], "evidence": [ { "id": "60324", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60324" } ] }, { "id": "60344", "name": "", "equation": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LMB9-1", "Q2YDJ8-1", "Q29RP8-1", "A6QPM3-1", "E1B906-1", "G3X834-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1" ], "evidence": [ { "id": "60344", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60344" } ] }, { "id": "60348", "name": "", "equation": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LMB9-1", "A0A3Q1M6A7-1", "Q29RP8-1", "E1B906-1", "G3X834-1", "A0A3Q1MPX3-1", "A0AAA9SSU7-1" ], "evidence": [ { "id": "60348", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60348" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMB9", "gene_name": "KMT5B", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1LMB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB9" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1LMB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB9" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A3Q1LMB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB9" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "A0A3Q1LMB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB9" } ] } ] }, { "uniprot_ac": "A0A3Q1LVN6", "gene_name": "PRDM2", "activity": [ { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6" } ] }, { "ec_number": "2.1.1.355", "activity": "", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6" } ] } ] }, { "uniprot_ac": "A0A3Q1M6A7", "gene_name": "KMT5C", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1M6A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6A7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1M6A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6A7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A3Q1M6A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6A7" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "A0A3Q1M6A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6A7" } ] } ] }, { "uniprot_ac": "A0A3Q1MPX3", "gene_name": "PRDM9", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.355", "activity": "", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "A0A3Q1MPX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPX3" } ] } ] }, { "uniprot_ac": "A0A3S5ZPV5", "gene_name": "SMYD5", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0A3S5ZPV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPV5" } ] }, { "ec_number": "2.1.1.372", "activity": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0A3S5ZPV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPV5" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "A0A3S5ZPV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPV5" } ] }, { "ec_number": "2.1.1.372", "activity": "", "evidence": [ { "id": "A0A3S5ZPV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPV5" } ] } ] }, { "uniprot_ac": "A0AAA9SSU7", "gene_name": "", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.355", "activity": "", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" } ] } ] }, { "uniprot_ac": "A0AAA9TB51", "gene_name": "SMYD3", "activity": [ { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "A0AAA9TB51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "A0AAA9TB51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ] } ] }, { "uniprot_ac": "A0ABI0NZS0", "gene_name": "SETD7", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A0ABI0NZS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZS0" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "A0ABI0NZS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZS0" } ] } ] }, { "uniprot_ac": "A4FV98", "gene_name": "EEF1AKMT3", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "A4FV98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV98" } ] } ] }, { "uniprot_ac": "A5PK19", "gene_name": "METTL13", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "A5PK19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PK19" } ] } ] }, { "uniprot_ac": "A6QP81", "gene_name": "METTL21C", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "A6QP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP81" } ] } ] }, { "uniprot_ac": "A6QPM3", "gene_name": "PRDM6", "activity": [ { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A6QPM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPM3" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "A6QPM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPM3" } ] } ] }, { "uniprot_ac": "E1B906", "gene_name": "SETD4", "activity": [ { "ec_number": "2.1.1.364", "activity": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1B906", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B906" } ] }, { "ec_number": "2.1.1.364", "activity": "", "evidence": [ { "id": "E1B906", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B906" } ] } ] }, { "uniprot_ac": "E1BGA4", "gene_name": "ASH1L", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "E1BGA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA4" } ] }, { "ec_number": "2.1.1.367", "activity": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1BGA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA4" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "E1BGA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA4" } ] }, { "ec_number": "2.1.1.367", "activity": "", "evidence": [ { "id": "E1BGA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGA4" } ] } ] }, { "uniprot_ac": "E1BI64", "gene_name": "SETD6", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "E1BI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI64" } ] } ] }, { "uniprot_ac": "F1MDT8", "gene_name": "SETD2", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "F1MDT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDT8" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "F1MDT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDT8" } ] } ] }, { "uniprot_ac": "F1MZS3", "gene_name": "SMYD1", "activity": [ { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "F1MZS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZS3" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "F1MZS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZS3" } ] } ] }, { "uniprot_ac": "G3X834", "gene_name": "", "activity": [ { "ec_number": "2.1.1.359", "activity": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.355", "activity": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.355", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.362", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.359", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "G3X834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X834" } ] } ] }, { "uniprot_ac": "P0DPE2", "gene_name": "EEF1AKMT4-ECE2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "P0DPE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0DPE2" } ] }, { "ec_number": "3.4.24.71", "activity": "Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.", "evidence": [ { "id": "P0DPE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0DPE2" } ] }, { "ec_number": "3.4.24.71", "activity": "", "evidence": [ { "id": "P0DPE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0DPE2" } ] } ] }, { "uniprot_ac": "Q0P585", "gene_name": "SMYD2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q0P585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P585" } ] }, { "ec_number": "2.1.1.354", "activity": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "Q0P585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P585" } ] }, { "ec_number": "2.1.1.354", "activity": "", "evidence": [ { "id": "Q0P585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P585" } ] } ] }, { "uniprot_ac": "Q29RP8", "gene_name": "KMT5B", "activity": [ { "ec_number": "2.1.1.362", "activity": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q29RP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RP8" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q29RP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RP8" } ] } ] }, { "uniprot_ac": "Q2YDJ8", "gene_name": "KMT5A", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q2YDJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ8" } ] }, { "ec_number": "2.1.1.361", "activity": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q2YDJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ8" } ] }, { "ec_number": "2.1.1.361", "activity": "", "evidence": [ { "id": "Q2YDJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 552, "end_pos": 579, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SSU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSU7" }, { "id": "PS50280", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50280" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SET", "eco_id": "ECO_0000259", "start_pos": 240, "end_pos": 354, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.359", "ec_name": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "2.1.1.359", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359" }, { "id": "2.1.1.359", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.359" } ] }, { "ec_number": "2.1.1.355", "ec_name": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "2.1.1.355", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355" }, { "id": "2.1.1.355", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.355" } ] }, { "ec_number": "2.1.1.354", "ec_name": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "2.1.1.354", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354" }, { "id": "2.1.1.354", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.354" } ] }, { "ec_number": "2.1.1.362", "ec_name": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.362", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362" }, { "id": "2.1.1.362", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.362" } ] }, { "ec_number": "2.1.1.361", "ec_name": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.361", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361" }, { "id": "2.1.1.361", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.361" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 232, "end_pos": 234 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSY5-1", "uniprot_ac": "A0AAA9SSY5", "uniprot_id": "A0AAA9SSY5_BOVIN", "mass": { "chemical_mass": 35227.0, "monoisotopic_mass": 35227.0 }, "refseq": { "ac": "NP_001377444", "name": "olfactory receptor family 2 subfamily A member 67", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377444" }, "gene_names": [ { "name": "OR2A67", "type": "recommended", "evidence": [ { "id": "A0AAA9SSY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5" } ] }, { "name": "OR2A67", "type": "synonym", "evidence": [ { "id": "NP_001377444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377444" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SSY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 2A2", "type": "synonym", "evidence": [ { "id": "NP_001377444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377444" } ] }, { "name": "olfactory receptor family 2 subfamily A member 67", "type": "synonym", "evidence": [ { "id": "NP_001377444", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377444" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377444" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2A67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5", "locus": { "chromosome": "4", "start_pos": 107431691, "end_pos": 107404372, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056096", "url": "https://www.ensembl.org/id/ENSBTAG00000056096" } ] } } ], "crossref": [ { "id": "cd15420", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15420", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787786", "url": "https://www.ncbi.nlm.nih.gov/gene/787786", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787786", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787786", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERNQSQITEFILVGFQLSKNMELLLFGIFSLLYVCNLLANGMILGLICLDPRLHSPMYFFLSHLAIIDISFPSSNLPTFLENLVKHTKSISFDPCTVQMLFNLTFGSIECLILLAMSYDRYVAICHPLQYTVIMNWRVCSILAIACWACGFALALVQVILLLRLPFCGPQKVNHFFCDIRSVLKLACGDIWMNEMFLFADGVLYLVGPLALVLVSYMRILWAILKIQSKKGRKKAFSTCSSHLCVVGFYFGLAMIVYMVPDNSQQEEHLKILFLFYTLFNPLLNPLVYSVRNAQVKAAFHRVLQKKTT", "length": 309, "header": "tr|A0AAA9SSY5-1|A0AAA9SSY5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A67 PE=3 SV=1 CANONICAL=A0AAA9SSY5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5/entry#A0AAA9SSY5-1", "sequence": { "sequence": "MERNQSQITEFILVGFQLSKNMELLLFGIFSLLYVCNLLANGMILGLICLDPRLHSPMYFFLSHLAIIDISFPSSNLPTFLENLVKHTKSISFDPCTVQMLFNLTFGSIECLILLAMSYDRYVAICHPLQYTVIMNWRVCSILAIACWACGFALALVQVILLLRLPFCGPQKVNHFFCDIRSVLKLACGDIWMNEMFLFADGVLYLVGPLALVLVSYMRILWAILKIQSKKGRKKAFSTCSSHLCVVGFYFGLAMIVYMVPDNSQQEEHLKILFLFYTLFNPLLNPLVYSVRNAQVKAAFHRVLQKKTT", "length": 309, "header": "tr|A0AAA9SSY5-1|A0AAA9SSY5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2A67 PE=3 SV=1 CANONICAL=A0AAA9SSY5-1" }, "locus": { "chromosome": "4", "start_pos": 107430958, "end_pos": 107430032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091598.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091598.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095508.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095508.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787786", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787786", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSY5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SSZ5-1", "uniprot_ac": "A0AAA9SSZ5", "uniprot_id": "A0AAA9SSZ5_BOVIN", "mass": { "chemical_mass": 33633.0, "monoisotopic_mass": 33633.0 }, "refseq": { "ac": "XP_005218758", "name": "CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218758" }, "gene_names": [ { "name": "CMTM4", "type": "recommended", "evidence": [ { "id": "A0AAA9SSZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5" } ] }, { "name": "CMTM4", "type": "synonym", "evidence": [ { "id": "XP_005218758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218758" } ] } ], "protein_names": [ { "name": "CKLF like MARVEL transmembrane domain containing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SSZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5/entry#names_and_taxonomy" } ] }, { "name": "CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218758" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CMTM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5", "locus": { "chromosome": "18", "start_pos": 34356739, "end_pos": 34436185, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001104", "url": "https://www.ensembl.org/id/ENSBTAG00000001104" } ] } } ], "crossref": [ { "id": "A0AAA9SSZ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SSZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001104", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001104", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540247", "url": "https://www.ncbi.nlm.nih.gov/gene/540247", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HECASFR", "url": "https://omabrowser.org/oma/group/HECASFR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6RCZ6", "url": "https://www.orthodb.org/?gene=F6RCZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22776", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22776", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22776:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22776:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218758", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218758", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RCZ6", "url": "https://www.uniprot.org/uniprotkb/F6RCZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RCZ6-1", "url": "https://www.uniprot.org/uniprotkb/F6RCZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGCLKVAQVILALIAFICIETIMECSPCEGLYFFEFVSCSAFVVTGVLLILFSLNLHMRIPQINWNLTDLVNTGLSTFFFFIASIVLAALNHKTGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSLRQQSANDYIRARTESRDVDSRPEIQRLDTFAQAILLCGHQLASARVRRPAAGVGVGTLLVSGSSSTRISGSWMPWIGWTALSGFRPKHTRFCAVMSLVKTQMTFHFPAPAGLSYVWSREILRKLAESI", "length": 307, "header": "tr|A0AAA9SSZ5-1|A0AAA9SSZ5_BOVIN Isoform 1 of CKLF like MARVEL transmembrane domain containing 4 OS=Bos taurus OX=9913 GN=CMTM4 PE=4 SV=1 CANONICAL=A0AAA9SSZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5/entry#A0AAA9SSZ5-1", "sequence": { "sequence": "MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGCLKVAQVILALIAFICIETIMECSPCEGLYFFEFVSCSAFVVTGVLLILFSLNLHMRIPQINWNLTDLVNTGLSTFFFFIASIVLAALNHKTGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSLRQQSANDYIRARTESRDVDSRPEIQRLDTFAQAILLCGHQLASARVRRPAAGVGVGTLLVSGSSSTRISGSWMPWIGWTALSGFRPKHTRFCAVMSLVKTQMTFHFPAPAGLSYVWSREILRKLAESI", "length": 307, "header": "tr|A0AAA9SSZ5-1|A0AAA9SSZ5_BOVIN Isoform 1 of CKLF like MARVEL transmembrane domain containing 4 OS=Bos taurus OX=9913 GN=CMTM4 PE=4 SV=1 CANONICAL=A0AAA9SSZ5-1" }, "locus": { "chromosome": "18", "start_pos": 34436021, "end_pos": 34357743, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108480.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108480.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087240.1" } ] } }, { "isoform_ac": "F6RCZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5/entry#F6RCZ6-1", "sequence": { "sequence": "MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGCLKVAQVILALIAFICIETIMECSPCEGLYFFEFVSCSAFVVTGVLLILFSLNLHMRIPQINWNLTDLVNTGLSTFFFFIASIVLAALNHKTGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSLRQQSANDYIRARTESRDVDSRPEIQRLDTFLPSLNTPRLDCRFSVILPSQIKATGETQSVPPVQTLAHLLASRTTDSLRPSSSVATSLPLPV", "length": 271, "header": "tr|F6RCZ6-1|F6RCZ6_BOVIN Computationally mapped isoform of CKLF like MARVEL transmembrane domain containing 4 OS=Bos taurus OX=9913 GN=CMTM4 PE=4 SV=2 CANONICAL=A0AAA9SSZ5-1" }, "locus": { "chromosome": "18", "start_pos": 34436021, "end_pos": 34357991, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001461.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001461.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001461.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001461.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SSZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSZ5" }, { "id": "PS51225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MARVEL", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 176, "start_aa": "Tyr", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST44-1", "uniprot_ac": "A0AAA9ST44", "uniprot_id": "A0AAA9ST44_BOVIN", "mass": { "chemical_mass": 32009.0, "monoisotopic_mass": 32009.0 }, "refseq": {}, "gene_names": [ { "name": "DTWD2", "type": "recommended", "evidence": [ { "id": "A0AAA9ST44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ] } ], "protein_names": [ { "name": "tRNA-uridine aminocarboxypropyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9ST44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.25", "type": "synonym", "evidence": [ { "id": "A0AAA9ST44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DTWD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44", "locus": { "chromosome": "7", "start_pos": 34958069, "end_pos": 34850843, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002143", "url": "https://www.ensembl.org/id/ENSBTAG00000002143" } ] } } ], "crossref": [ { "id": "A0AAA9ST44", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST44", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002143", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002143", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039262", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039262", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BNX7", "url": "https://www.orthodb.org/?gene=E1BNX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21392", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21392", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21392:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21392:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03942", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03942", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "62432", "url": "https://www.rhea-db.org/rhea/62432", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9ST44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNX7", "url": "https://www.uniprot.org/uniprotkb/E1BNX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNX7-1", "url": "https://www.uniprot.org/uniprotkb/E1BNX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQHHEARTPGDPVAWLPGTLRSQTPEEEEPRVGGSAPAASVLDAEAYGASADGLWELPVEPAERRPECSHCSRPQKVCLCPFLPAHPLHISTYLYIIQHPAEENKVLRTVPLLAACLPKDKCKIKIGRRFSEERDPELSTICRKSDTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRLPKQVQLKTSISSQYVIRAQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGFLTFQCPHGFLDN", "length": 286, "header": "tr|A0AAA9ST44-1|A0AAA9ST44_BOVIN Isoform 1 of tRNA-uridine aminocarboxypropyltransferase OS=Bos taurus OX=9913 GN=DTWD2 PE=3 SV=1 CANONICAL=A0AAA9ST44-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44/entry#A0AAA9ST44-1", "sequence": { "sequence": "MEQHHEARTPGDPVAWLPGTLRSQTPEEEEPRVGGSAPAASVLDAEAYGASADGLWELPVEPAERRPECSHCSRPQKVCLCPFLPAHPLHISTYLYIIQHPAEENKVLRTVPLLAACLPKDKCKIKIGRRFSEERDPELSTICRKSDTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRLPKQVQLKTSISSQYVIRAQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGFLTFQCPHGFLDN", "length": 286, "header": "tr|A0AAA9ST44-1|A0AAA9ST44_BOVIN Isoform 1 of tRNA-uridine aminocarboxypropyltransferase OS=Bos taurus OX=9913 GN=DTWD2 PE=3 SV=1 CANONICAL=A0AAA9ST44-1" }, "locus": { "chromosome": "7", "start_pos": 34958047, "end_pos": 34850928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110224.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110224.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087294.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087294.1" } ] } }, { "isoform_ac": "A0AAA9TSB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44/entry#A0AAA9TSB9-1", "sequence": { "sequence": "IATALYRPQKVCLCPFLPAHPLHISTYLYIIQHPAEENKVLRTVPLLAACLPKDKCKIKIGRRFSEERDPELSTICRKSDTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRLPKQVQLKTSISSQYVIRAQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLYPKPMPKNKRKLRKMELLMNSVKI", "length": 231, "header": "tr|A0AAA9TSB9-1|A0AAA9TSB9_BOVIN Computationally mapped isoform of tRNA-uridine aminocarboxypropyltransferase OS=Bos taurus OX=9913 GN=DTWD2 PE=3 SV=1 CANONICAL=A0AAA9ST44-1" }, "locus": { "chromosome": "7", "start_pos": 34923407, "end_pos": 34851344, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092391.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092391.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101277.1" } ] } }, { "isoform_ac": "A0AAA9TWJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44/entry#A0AAA9TWJ6-1", "sequence": { "sequence": "MEQHHEARTPGDPVAWLPGTLRSQTPEEEEPRVGGSAPAASVLDAEAYGASADGLWELPVEPAERRPECSHCSRPQKVCLCPFLPAHPLHISTYLYIIQHPAEENKVLRTVPLLAACLPKDKCKIKIGRRFSEERDPELSTICRKSDTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRLPKQVQLKTSISSQYVIRAQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLILGSFP", "length": 280, "header": "tr|A0AAA9TWJ6-1|A0AAA9TWJ6_BOVIN Computationally mapped isoform of tRNA-uridine aminocarboxypropyltransferase OS=Bos taurus OX=9913 GN=DTWD2 PE=3 SV=1 CANONICAL=A0AAA9ST44-1" }, "locus": { "chromosome": "7", "start_pos": 34927183, "end_pos": 34850928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101831.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101831.1" } ] } }, { "isoform_ac": "E1BNX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44/entry#E1BNX7-1", "sequence": { "sequence": "MEQHHEARTPGDPVAWLPGTLRSQTPEEEEPRVGGSAPAASVLDAEAYGASADGLWELPVEPAERRPECSHCSRPQKVCLCPFLPAHPLHISTYLYIIQHPAEVQLKTSISSQYVIRAQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLYPKPMPKNKRKLRKMELLMNSVKI", "length": 202, "header": "tr|E1BNX7-1|E1BNX7_BOVIN Computationally mapped isoform of tRNA-uridine aminocarboxypropyltransferase OS=Bos taurus OX=9913 GN=DTWD2 PE=3 SV=3 CANONICAL=A0AAA9ST44-1" }, "locus": { "chromosome": "7", "start_pos": 34923407, "end_pos": 34850928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002778.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002778.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002778.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002778.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ], "pmid": "" }, { "name": "glycoRNA biosynthetic process", "id": "GO:0141217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141217", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ], "pmid": "" }, { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "tRNA-uridine aminocarboxypropyltransferase activity", "id": "GO:0016432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016432", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "62432", "name": "", "equation": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9ST44-1", "A0AAA9TMA7-1" ], "evidence": [ { "id": "62432", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/62432" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9ST44", "gene_name": "DTWD2", "activity": [ { "ec_number": "2.5.1.25", "activity": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+).", "evidence": [ { "id": "A0AAA9ST44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ] }, { "ec_number": "2.5.1.25", "activity": "", "evidence": [ { "id": "A0AAA9ST44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" } ] } ] }, { "uniprot_ac": "A0AAA9TMA7", "gene_name": "DTWD1", "activity": [ { "ec_number": "2.5.1.25", "activity": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+).", "evidence": [ { "id": "A0AAA9TMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMA7" } ] }, { "ec_number": "2.5.1.25", "activity": "", "evidence": [ { "id": "A0AAA9TMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMA7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST44" }, { "id": "SM01144", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01144" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DTW", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 260, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.25", "ec_name": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+).", "evidence": [ { "id": "2.5.1.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST54-1", "uniprot_ac": "A0AAA9ST54", "uniprot_id": "A0AAA9ST54_BOVIN", "mass": { "chemical_mass": 61550.0, "monoisotopic_mass": 61550.0 }, "refseq": { "ac": "XP_024839611", "name": "zinc finger protein 76 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839611" }, "gene_names": [ { "name": "ZNF76", "type": "recommended", "evidence": [ { "id": "A0AAA9ST54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ] }, { "name": "ZNF76", "type": "synonym", "evidence": [ { "id": "XP_024839611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839611" } ] } ], "protein_names": [ { "name": "Zinc finger protein 76", "type": "recommended", "evidence": [ { "id": "A0AAA9ST54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 523", "type": "synonym", "evidence": [ { "id": "A0AAA9ST54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 76 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839611" } ] } ], "function": [ { "annotation": "Transcription factor that regulates expression of genes transcribed by both RNA polymerases II and III. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in many promoters. Able to activate expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also regulates expression of mRNAs and acts as a DNA-binding transcription repressor that inhibits the activity of the TATA-binding protein (TBP).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54#function" }, { "database": "UniProtKB", "id": "ARBA00094296", "url": "https://www.uniprot.org/uniprotkb/ARBA00094296#function" }, { "database": "UniProtKB", "id": "E1BND9", "url": "https://www.uniprot.org/uniprotkb/E1BND9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54", "locus": { "chromosome": "23", "start_pos": 9270069, "end_pos": 9239747, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006170", "url": "https://www.ensembl.org/id/ENSBTAG00000006170" } ] } } ], "crossref": [ { "id": "A0AAA9ST54", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST54", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006170", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006170", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100300346", "url": "https://www.ncbi.nlm.nih.gov/gene/100300346", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100300346", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300346", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818:SF151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818:SF151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839611", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839611", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BND9", "url": "https://www.uniprot.org/uniprotkb/E1BND9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BND9-1", "url": "https://www.uniprot.org/uniprotkb/E1BND9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESLGLQTVTLSDGTTAYVQQAVKGDKLLEGQVIQLEDGTTAYIHQVTVQKEPLSFEDGQPVQLEDGSMAYIHRTPKEGYDPSALEAVQLEDGSTAYIHHPVAVPSDGAILAVQTEVGLEGLAAEDDEGFSADTVVALEQYTSKVLHESQAPHNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHMRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPHIAYVSEVKEEGDDLPTQVAMVTEEDGAPQVALITQDGAQQVSLSPEDLQALGSAISMVTQHGSTTLAIPSHDDTLATSGAHTVAMVSADGTQTQPVTIITSGTVVAEDSSVASLHHQQVALLATANGTHIAVQLEAQQTLEEAISVATAAMQRGAATLETAESESSC", "length": 570, "header": "tr|A0AAA9ST54-1|A0AAA9ST54_BOVIN Isoform 1 of Zinc finger protein 76 OS=Bos taurus OX=9913 GN=ZNF76 PE=3 SV=1 CANONICAL=A0AAA9ST54-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54/entry#A0AAA9ST54-1", "sequence": { "sequence": "MESLGLQTVTLSDGTTAYVQQAVKGDKLLEGQVIQLEDGTTAYIHQVTVQKEPLSFEDGQPVQLEDGSMAYIHRTPKEGYDPSALEAVQLEDGSTAYIHHPVAVPSDGAILAVQTEVGLEGLAAEDDEGFSADTVVALEQYTSKVLHESQAPHNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHMRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPHIAYVSEVKEEGDDLPTQVAMVTEEDGAPQVALITQDGAQQVSLSPEDLQALGSAISMVTQHGSTTLAIPSHDDTLATSGAHTVAMVSADGTQTQPVTIITSGTVVAEDSSVASLHHQQVALLATANGTHIAVQLEAQQTLEEAISVATAAMQRGAATLETAESESSC", "length": 570, "header": "tr|A0AAA9ST54-1|A0AAA9ST54_BOVIN Isoform 1 of Zinc finger protein 76 OS=Bos taurus OX=9913 GN=ZNF76 PE=3 SV=1 CANONICAL=A0AAA9ST54-1" }, "locus": { "chromosome": "23", "start_pos": 9269065, "end_pos": 9255024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114752.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114752.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089600.1" } ] } }, { "isoform_ac": "E1BND9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54/entry#E1BND9-1", "sequence": { "sequence": "MESLGLQTVTLSDGTTAYVQQAVKGDKLLEGQVIQLEDGTTAYIHQVTVQKEPLSFEDGQPVQLEDGSMAYIHRTPKEGYDPSALEAVQLEDGSTAYIHHPVAVPSDGAILAVQTEVGLEGLAAEDDEGFSADTVVALEQYTSKVLHESQAPHNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHMRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPHIAYVSEVKEEGDDLPTQVAMVTEEDGAPQVALITQDGAQQVTIITSGTVVAEDSSVASLHHQQVALLATANGTHIAVQLEAQQTLEEAISVATAAMQRGAATLETAESESSC", "length": 515, "header": "tr|E1BND9-1|A0AAA9ST54_BOVIN Computationally mapped isoform of Zinc finger protein 76 OS=Bos taurus OX=9913 GN=ZNF76 PE=3 SV=4 CANONICAL=A0AAA9ST54-1" }, "locus": { "chromosome": "23", "start_pos": 9269065, "end_pos": 9255024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008112.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008112.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008112.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008112.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100300346", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300346", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST54" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 165, "end_pos": 194, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 529, "end_pos": 531 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST57-1", "uniprot_ac": "A0AAA9ST57", "uniprot_id": "A0AAA9ST57_BOVIN", "mass": { "chemical_mass": 14439.0, "monoisotopic_mass": 14439.0 }, "refseq": {}, "gene_names": [ { "name": "SRXN1", "type": "recommended", "evidence": [ { "id": "A0AAA9ST57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ] } ], "protein_names": [ { "name": "Sulfiredoxin", "type": "recommended", "evidence": [ { "id": "A0AAA9ST57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57/entry#names_and_taxonomy" } ] }, { "name": "1.8.98.2", "type": "synonym", "evidence": [ { "id": "A0AAA9ST57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57#function" }, { "database": "UniProtKB", "id": "ARBA00059800", "url": "https://www.uniprot.org/uniprotkb/ARBA00059800#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRXN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57", "locus": {} } ], "crossref": [ { "id": "A0AAA9ST57", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST57", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16395", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16395", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016692", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016692", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21348", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21348", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21348:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21348:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02195", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02195", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17545", "url": "https://www.rhea-db.org/rhea/17545", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGLRAGGALSRAGAGRGAPEVPGPSGGAQGGSIHSGCITAVHNVPLSVLIRPLPSVLDQAKVQSLVDTIRENPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ", "length": 138, "header": "tr|A0AAA9ST57-1|A0AAA9ST57_BOVIN Isoform 1 of Sulfiredoxin OS=Bos taurus OX=9913 GN=SRXN1 PE=3 SV=2 CANONICAL=A0AAA9ST57-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57/entry#A0AAA9ST57-1", "sequence": { "sequence": "MMGLRAGGALSRAGAGRGAPEVPGPSGGAQGGSIHSGCITAVHNVPLSVLIRPLPSVLDQAKVQSLVDTIRENPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ", "length": 138, "header": "tr|A0AAA9ST57-1|A0AAA9ST57_BOVIN Isoform 1 of Sulfiredoxin OS=Bos taurus OX=9913 GN=SRXN1 PE=3 SV=2 CANONICAL=A0AAA9ST57-1" }, "locus": { "chromosome": "13", "start_pos": 60408031, "end_pos": 60403289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132155.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132155.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087309.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087309.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ], "pmid": "" }, { "name": "sulfiredoxin activity", "id": "GO:0032542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17545", "name": "", "equation": "S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9ST57-1" ], "evidence": [ { "id": "17545", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17545" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9ST57", "gene_name": "SRXN1", "activity": [ { "ec_number": "1.8.98.2", "activity": "S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate.", "evidence": [ { "id": "A0AAA9ST57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ] }, { "ec_number": "1.8.98.2", "activity": "", "evidence": [ { "id": "A0AAA9ST57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST57" }, { "id": "SM00470", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00470" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ParB-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 136, "start_aa": "His", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.8.98.2", "ec_name": "S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate.", "evidence": [ { "id": "1.8.98.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.98.2" }, { "id": "1.8.98.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.8.98.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST58-1", "uniprot_ac": "A0AAA9ST58", "uniprot_id": "A0AAA9ST58_BOVIN", "mass": { "chemical_mass": 131237.0, "monoisotopic_mass": 131237.0 }, "refseq": { "ac": "XP_002694254", "name": "laminin subunit gamma-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694254" }, "gene_names": [ { "name": "LAMC2", "type": "recommended", "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ] }, { "name": "LAMC2", "type": "synonym", "evidence": [ { "id": "XP_002694254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694254" } ] } ], "protein_names": [ { "name": "Laminin subunit gamma-2", "type": "recommended", "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#names_and_taxonomy" } ] }, { "name": "Epiligrin subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#names_and_taxonomy" } ] }, { "name": "Kalinin subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#names_and_taxonomy" } ] }, { "name": "Laminin-5 subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#names_and_taxonomy" } ] }, { "name": "Nicein subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#names_and_taxonomy" } ] }, { "name": "laminin subunit gamma-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002694254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694254" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAMC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58", "locus": { "chromosome": "16", "start_pos": 64290610, "end_pos": 64213876, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000793", "url": "https://www.ensembl.org/id/ENSBTAG00000000793" } ] } } ], "crossref": [ { "id": "A0AAA9ST58", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST58", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000793", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000793", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511043", "url": "https://www.ncbi.nlm.nih.gov/gene/511043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511043", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511043", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ARWVQTC", "url": "https://omabrowser.org/oma/group/ARWVQTC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7Q3", "url": "https://www.orthodb.org/?gene=E1B7Q3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574:SF313", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF313", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694254", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694254", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q3", "url": "https://www.uniprot.org/uniprotkb/E1B7Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPALWLSGCLCLSLLLPAARANSRTPVCDCNGKSRQCIFDQELHRLTGNGFRCLHCSDNTGGIHCERCKEGFYRHRERDRCLPCNCNSKGSLSPRCDNTGRCSCKPGVTGDRCDRCLPGFHTLTDAGCTQDRKLLDSKCDCDPAGIVGPCDTGRCVCKPAVTGERCDRCRPGYYHLDGRNPEGCTQCFCYGHSASCQSSGDYSVHKITSTFHQDVDGWKAVQRNGFPAKLQWSQRHQDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLQITAPLMPRDKTLPCGITKTYTFRLNEHPSSNWRPKLSYFEYRRLLRNLTALRIRATYGEYSTGYLDNVTLISARPVSGTPAPWVEQCVCPVGYKGQFCHECASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECEDCPIGFYNDPHDPGSCKPCPCRNGFSCSVMPETEEVVCNNCPHGITGARCELCADGYFGDPFGEHGPVRPCQPCQCSDNVDPSAPGNCDRLTGRCLKCLHNTTGAHCDQCKAGYYGDPLAPNPADKCRACNCNPMGSEPVECRSDGSCVCKPGFDGLNCDHAALTNCPACYNQVKSQMDQFMQQLESLETLLSKAQAGGGAVPDTELEGRMQQAEQALQDLLREAQISEGAIRSLNLQLAKARSQENSYQTRLDDLKMTVERLRTLGSQHQDRVQDTRRLITQMRLSLEESEAALRNTNIPPSEHYTGPNGFKSLAQEATRLADSHVESANNMEQLVRETEDYSKQALTLARKAAAEGGSSGSLRGSVVQELGGKLEKIKSLAQQLSREATQIDNEADTSYQHSLRLLSSATQLQGVNDQSFQVEAKKIRQKADSLSSLVTKRMDEFKRVQSSLGNWEEETQKLLQDGKNERQKSDQLLSRANLAKSRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSYISQKVADASDKTRRAETALGGAATDAQRAKTAAGEALKIAGKIEQEIGSLNVEANVTADGALAMEKGLATLKSEMRKVEGELARKEREFDVDMDTVQMVITEAQRVDSRAKNAGVTIQDTLNTLDGILHLIDQPGSVDEEGLILLEQKLFRAKTQINSQLRPLMSELEERVRWQRGHLHSLETSIDGILADVKNLENIRDNLPPGCYNTQALEQH", "length": 1191, "header": "tr|A0AAA9ST58-1|A0AAA9ST58_BOVIN Isoform 1 of Laminin subunit gamma-2 OS=Bos taurus OX=9913 GN=LAMC2 PE=1 SV=1 CANONICAL=A0AAA9ST58-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#A0AAA9ST58-1", "sequence": { "sequence": "MPALWLSGCLCLSLLLPAARANSRTPVCDCNGKSRQCIFDQELHRLTGNGFRCLHCSDNTGGIHCERCKEGFYRHRERDRCLPCNCNSKGSLSPRCDNTGRCSCKPGVTGDRCDRCLPGFHTLTDAGCTQDRKLLDSKCDCDPAGIVGPCDTGRCVCKPAVTGERCDRCRPGYYHLDGRNPEGCTQCFCYGHSASCQSSGDYSVHKITSTFHQDVDGWKAVQRNGFPAKLQWSQRHQDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLQITAPLMPRDKTLPCGITKTYTFRLNEHPSSNWRPKLSYFEYRRLLRNLTALRIRATYGEYSTGYLDNVTLISARPVSGTPAPWVEQCVCPVGYKGQFCHECASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECEDCPIGFYNDPHDPGSCKPCPCRNGFSCSVMPETEEVVCNNCPHGITGARCELCADGYFGDPFGEHGPVRPCQPCQCSDNVDPSAPGNCDRLTGRCLKCLHNTTGAHCDQCKAGYYGDPLAPNPADKCRACNCNPMGSEPVECRSDGSCVCKPGFDGLNCDHAALTNCPACYNQVKSQMDQFMQQLESLETLLSKAQAGGGAVPDTELEGRMQQAEQALQDLLREAQISEGAIRSLNLQLAKARSQENSYQTRLDDLKMTVERLRTLGSQHQDRVQDTRRLITQMRLSLEESEAALRNTNIPPSEHYTGPNGFKSLAQEATRLADSHVESANNMEQLVRETEDYSKQALTLARKAAAEGGSSGSLRGSVVQELGGKLEKIKSLAQQLSREATQIDNEADTSYQHSLRLLSSATQLQGVNDQSFQVEAKKIRQKADSLSSLVTKRMDEFKRVQSSLGNWEEETQKLLQDGKNERQKSDQLLSRANLAKSRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSYISQKVADASDKTRRAETALGGAATDAQRAKTAAGEALKIAGKIEQEIGSLNVEANVTADGALAMEKGLATLKSEMRKVEGELARKEREFDVDMDTVQMVITEAQRVDSRAKNAGVTIQDTLNTLDGILHLIDQPGSVDEEGLILLEQKLFRAKTQINSQLRPLMSELEERVRWQRGHLHSLETSIDGILADVKNLENIRDNLPPGCYNTQALEQH", "length": 1191, "header": "tr|A0AAA9ST58-1|A0AAA9ST58_BOVIN Isoform 1 of Laminin subunit gamma-2 OS=Bos taurus OX=9913 GN=LAMC2 PE=1 SV=1 CANONICAL=A0AAA9ST58-1" }, "locus": { "chromosome": "16", "start_pos": 64289606, "end_pos": 64223929, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098620.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098620.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087169.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087169.1" } ] } }, { "isoform_ac": "E1B7Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58/entry#E1B7Q3-1", "sequence": { "sequence": "ALAVWAHDGTHVPFCDCNGKSRQCIFDQELHRLTGNGFRCLHCSDNTGGIHCERCKEGFYRHRERDRCLPCNCNSKGSLSPRCDNTGRCSCKPGVTGDRCDRCLPGFHTLTDAGCTQDRKLLDSKCDCDPAGIVGPCDTGRCVCKPAVTGERCDRCRPGYYHLDGRNPEGCTQCFCYGHSASCQSSGDYSVHKITSTFHQDVDGWKAVQRNGFPAKLQWSQRHQDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLQITAPLMPRDKTLPCGITKTYTFRLNEHPSSNWRPKLSYFEYRRLLRNLTALRIRATYGEYSTGYLDNVTLISARPVSGTPAPWVEQCVCPVGYKGQFCHECASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECEDCPIGFYNDPHDPGSCKPCPCRNGFSCSVMPETEEVVCNNCPHGITGARCELCADGYFGDPFGEHGPVRPCQPCQCSDNVDPSAPGNCDRLTGRCLKCLHNTTGAHCDQCKAGYYGDPLAPNPADKCRACNCNPMGSEPVECRSDGSCVCKPGFDGLNCDHAALTNCPACYNQVKSQMDQFMQQLESLETLLSKAQAGGGAVPDTELEGRMQQAEQALQDLLREAQISEGAIRSLNLQLAKARSQENSYQTRLDDLKMTVERLRTLGSQHQDRVQDTRRLITQMRLSLEESEAALRNTNIPPSEHYTGPNGFKSLAQEATRLADSHVESANNMEQLVRETEDYSKQALTLARKAAAEGGSSGSLRGSVVQELGGKLEKIKSLAQQLSREATQIDNEADTSYQHSLRLLSSATQLQGVNDQSFQVEAKKIRQKADSLSSLVTKRMDEFKRVQSSLGNWEEETQKLLQDGKNERQKSDQLLSRANLAKSRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSYISQKVADASDKTRRAETALGGAATDAQRAKTAAGEALKIAGKIEQEIGSLNVEANVTADGALAMEKGLATLKSEMRKVEGELARKEREFDVDMDTVQMVITEAQRVDSRAKNAGVTIQDTLNTLDGILHLIDQPGSVDEEGLILLEQKLFRAKTQINSQLRPLMSELEERVRWQRGHLHSLETSIDGILADVKNLENIRDNLPPGCYNTQALEQH", "length": 1178, "header": "tr|E1B7Q3-1|E1B7Q3_BOVIN Computationally mapped isoform of Laminin subunit gamma-2 OS=Bos taurus OX=9913 GN=LAMC2 PE=1 SV=3 CANONICAL=A0AAA9ST58-1" }, "locus": { "chromosome": "16", "start_pos": 64289606, "end_pos": 64241123, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061289.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061289.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053169.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053169.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 374, "start_aa": "Thr", "end_pos": 374, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr374", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:511043", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511043", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y9M6-1", "protein_name": "Laminin subunit gamma 2", "gene_name": "LAMC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATCWLLALAASLLPAALSTSGGEACDCNGMSRQCVFDWQLLMETGNGYRCLGCLGNTAGAHCERCKEGYYRQQDGDCCLPCRCHPQGSLSTQCDSNGRCSCRPGVMGEKCDRCQPGFHSLSEAGCQGYGQSQLCACDPAGTGDCVSGRCICKVGVTGERCDRCKQNFYNLDARNPAGCSPCFCYGHSSSCVSAENYSIHKITSSFQQGPEGWTGVHEDRSPTELQWSPRHQDVFIAARRWEALYFVAPAKFLGNQQLSYGQTLSFDYRLDRGGRLPSPHDVILEGGGLRVTAPFLPSGKVLPCGVSQTYTFRLDEHPSSKWSPRLNYFEYRRLLGNLTALWIRATFGEYSTGYIDNITLVSAQPAAGVLAPWVERCQCPDGYQGQFCERCAAGYRRDAPHMGPFSICVPCNCHGGGICDPDTGECYSGDENVGNSISCPFGSYRDPRPPHSCRACPCGHGQSCSVMLGQEEVVCDHCPPGAAGPRCEFCADGYFGDPAASQPCRPCQCNSNVEPNAVGNCDRRTGECLKCIYNTAGFHCERCKDGFFGNPLAPNPADKCRACNCNSVGAEPLMCRNDGSCICKPGFGGPNCEQSECPACYSQVKAQVDLYLQQLQELELLSSEVQAGGGAVGQELEGKMQLAEETLQAILREALSLQASDRSLESRVTRLKGQGSTCQSRLDDAKAAVERLMSLGRQYERQAQDARRLLETARLDLSNSGASLSQAAIPVSHFPGGSNKILLLAQEALSLANSHMQAANIIEQAAKAAQDDSQQALELLQAAVSGGAEVPGSLQGLLRKYEELKLLAGGLEADANRIATEADKAYQSSLMLLSSLSRLTKTSFGSFEGEAAQLKQDAAALLSTVDTYMAQYRQLQSRMGLWEEEIKKLLQRGEGERAMLTQLLSRANLARSTALQAVSAGNATFYEVEQILKSLRGFNLQADDKRREAEDAMRRLSVISSMVASAKEKTDRAEAILGNAAAESKAASSTAGEAKEITFGIQKEIMRLRLEANKTADGVLALEKAVAALQHEAKEVDGEFQSKVSEAEADAAMIQETTKEAQDVHTKAGQAGVVVQETLGVLEELLRLMNQPGAVDEEGLKQLELNFSKAKTKTNQLKEQMSELEQRATLQKVRVQKLDSSIDEILADIRNLEDIQRSLPPGCYNTKAIELP", "length": 1172 }, "evidence": [ { "id": "A0AAA9ST58", "url": "https://omabrowser.org/oma/group/A0AAA9ST58/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LM30-1", "protein_name": "Laminin subunit gamma-2", "gene_name": "Lamc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKVETDLGALELFGGLNTCATVCDCNGKSRQCVFDQELHRQTGNGFRCLNCNDNTAGVHCERCREGFYRQRDRDRCLPCNCHSKGSLGAGCDNSGQCRCKPGVVGQRCDRCQPGFHMLTDAGCTRDQRQLDSKCDCDPAGISGPCDSGRCVCKPAVTGERCDRCRAGYYHLDRANPEGCTQCFCYGHSDSCHTSADFSVHKITSTFNQDEDGWKAVQRNWAPAKLHWSPRHQDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAYDVILEGAGLQIRAPLMPPGKTLPCGITKTYTFRLNEHPSSHWSPQLSYFEYRRLLRNLTALLIRATYGEYSTGYIDNVTLISARPVSGAPAPWVERCVCPAGYKGQFCQECASGYKRDSARLGPFGTCVPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDPFGERGPVRPCQRCQCNNNVDPSASGNCDQLTGRCLKCIYNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPVGSEPGECRSDGSCVCKPGFGGLNCAHAAALTSCPACYNQVKTQMDQFAQQLQNLEALVSKAQGGNGAVPSEELEGRMQQAEQALRDILREAQISEGAMRALSLQLAKARSQENNYKNRLDDLKMTVERIRALGSQYQNRVQDTSRLISQMRLSLAESEASLQNTNIHSSEHYVGPNGFKSLAQEAARLADSHVESANTMKQLTRETEDYSKQALSLARKALSGGGGSGVLDSSVVQGLMGKLEKTKSLTQQLSREGTQADIEADRSYQHSLRLLDSASQLQGIRDSSFQAEAKRIRQKADSLSNLVTKQMDAFTSVRNNLGNWEKETRQLLQTGKDRRQTSDQLLSRANLAKSRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSYISQKVADASDKTQQAETALGSATADTQRAKNAATEALEITSEIEQEIGSLNLEANVTADGALAMEKGLATLKSEMREVEGELARKELEFHTDKDSLQLVITEAQQADARAKSTGVTIQDTLNTLEGILRLIDQPDAVDEEGLMLLEQELFQAKTQINSRLRPLMSELEDRARRQSNHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALEQQ", "length": 1188 }, "evidence": [ { "id": "A0AAA9ST58", "url": "https://omabrowser.org/oma/group/A0AAA9ST58/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S662-1", "protein_name": "Laminin subunit gamma-2", "gene_name": "LAMC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPALWLCGCLCLALLLPAARANSGTQVCDCNGKSRQCLFDQELHRLTGNGFRCLHCSDNTAGIHCEKCKEGFYRQRERDRCLPCNCNSKGSLSARCDNAGRCSCKPGVTGDRCDRCLPGFHTLTDAGCTQDQRLLDSKCDCDPAGILGPCDAGHCVCKPAVTGERCDRCRPGYYHLDGGNPEGCTQCFCYGHSASCQSSGDYSVYKVTSTFNQDVDGWKAVQRNGSPAKLQWSQRHQDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVVLEGAGLRITAPLMPLGKTLPCGITKTYTFRLNEHPSSHWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYLDNVTLVSARPVSGTPAPWVEQCVCPVGYKGQFCQECASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCRHGFSCSVMPETEEVVCHNCPHGVTGARCEHCADGYFGDPFGERGPVRPCQPCQCNNNVDPSASGNCDHLTGRCLKCIHNTAGAHCEQCKVGYFGDPLAPNPADKCRACNCNPVGSEPVACRSDGSCVCKPGFGGLNCEHAALTSCPACYNQVKTQMDQFMQQLQSLETLISKAQDGGGTIPNTELESRMQQTEQTLEDILREAQIAEGARTSLLRRLAKAKSQESSYRSRLDDLKMTLERARALDSQHQNRLRETHMLITQMRLRLEESEAALRNTNIPPSEHYVGPNGFKSLAQEAARLADSHVESANSMERLAREAEEFSKQALSLVRKALSDGGGSGRLDPSVAQGLVGKLEKTKSLAQQLLLEATQTDLEADRAYQQSLRLLNSASQLQGVNHQSFQVEVKRIKEKADSLSSLVTQRLDEFEHVQSNLGNWEEETRKLLQNGKNGRQKSDQLLSRANLAKSRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSYISQKVAEASDKTQRAETALGGAATDAQRAKHTAREALGITGKMEQEIRSLILKANVTADGALAMEKGLATVKSEMQDVEGELARKEREFDADMAAVQTVITEAQTVDNRAKNAGVTIQDTLNTLDGILHLIDQPGSVDEEGLILLEQKLFRAKTQINSQLRPLMSELEERALRQRGQLRSLEMSIDGILADVKNLEHIRDNLPPGCYNTQALEQH", "length": 1191 }, "evidence": [ { "id": "A0AAA9ST58", "url": "https://omabrowser.org/oma/group/A0AAA9ST58/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q13753-1", "protein_name": "Laminin subunit gamma-2", "gene_name": "LAMC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPALWLGCCLCFSLLLPAARATSRREVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPLSVDEEGLVLLEQKLSRAKTQINSQLRPMMSELEERARQQRGHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALEQQ", "length": 1193 }, "evidence": [ { "id": "A0AAA9ST58", "url": "https://omabrowser.org/oma/group/A0AAA9ST58/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61092-1", "protein_name": "Laminin subunit gamma-2", "gene_name": "Lamc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPALWLSCCLGVALLLPAAQATSRREVCDCNGKSRQCVFDQELHRQTGSGFRCLNCNDNTAGVHCERCREGFYRHRDRDRCLPCNCHSKGSLSAGCDNSGQCRCKPGVTGQRCDRCQPGFHMLTDAGCTRDQGQLDSKCDCDPAGISGPCDSGRCVCKPAVTGERCDRCRPGYYHLDRANPEGCTQCFCYGHSASCHASADFSVHKITSTFSQDVDGWKAVQRNGAPAKLHWSQRHRDVFSSARRSDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRQPSAYDVILEGAGLQIRAPLMAPGKTLPCGITKTYTFRLNEHPSSHWSPQLSYFEYRRLLRNLTALLIRATYGEYSTGYIDNVTLVSARPVSGAPAPWVERCVCPAGYKGQFCQECASGYKRDSARLGPFGACVPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDPFGERGPVRPCQRCQCNNNVDPNASGNCDQLTGRCLKCIYNTAGVYCDQCKAGYFGDPLAPNPADKCRACNCSPMGSEPGECRGDGSCVCKPGFGGLNCDHAALTSCPACYNQVKIQMDQFTQQLQSLEALVSKAQGGGGGGTVPVQLEGRIEQAEQALQDILGEAQISEGAMRAVAVRLAKARSQENDYKTRLDDLKMTAERIRALGSQHQNRVQDTSRLISQMRLSLAGSEALLENTNIHSSEHYVGPNDFKSLAQEATRKADSHAESANAMKQLARETEDYSKQALSLARKLLSGGGGSGSWDSSVVQGLMGKLEKTKSLSQQLSLEGTQADIEADRSYQHSLRLLDSASQLQGVSDLSFQVEAKRIRQKADSLSNLVTRQTDAFTRVRNNLGNWEKETRQLLQTGKDRRQTSDQLLSRANLAKNRAQEALSMGNATFYEVENILKNLREFDLQVEDRKAEAEEAMKRLSSISQKVADASDKTQQAETALGSATADTQRAKNAAREALEISSEIELEIGSLNLEANVTADGALAMEKGTATLKSEMREMIELARKELEFDTDKDTVQLVITEAQQADARATSAGVTIQDTLNTLDGILHLIDQPGSVDEEGMMLLEQGLFQAKTQINSRLRPLMSDLEERVRRQRNHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALEQQ", "length": 1191 }, "evidence": [ { "id": "A0AAA9ST58", "url": "https://omabrowser.org/oma/group/A0AAA9ST58/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1031, "end_pos": 1033, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 940, "end_pos": 942, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" }, { "id": "PS50027", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50027" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin EGF-like", "eco_id": "ECO_0000259", "start_pos": 84, "end_pos": 130, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9ST58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST58" }, { "id": "PS51115", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin IV type A", "eco_id": "ECO_0000259", "start_pos": 213, "end_pos": 381, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 374 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1031, "end_pos": 1033 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 940, "end_pos": 942 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST79-1", "uniprot_ac": "A0AAA9ST79", "uniprot_id": "A0AAA9ST79_BOVIN", "mass": { "chemical_mass": 211135.0, "monoisotopic_mass": 211135.0 }, "refseq": { "ac": "XP_059746358", "name": "protein NYNRIN isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746358" }, "gene_names": [ { "name": "NYNRIN", "type": "recommended", "evidence": [ { "id": "A0AAA9ST79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ] }, { "name": "NYNRIN", "type": "synonym", "evidence": [ { "id": "XP_059746358", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746358" } ] } ], "protein_names": [ { "name": "NYN domain and retroviral integrase containing", "type": "synonym", "evidence": [ { "id": "A0AAA9ST79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79/entry#names_and_taxonomy" } ] }, { "name": "protein NYNRIN isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059746358", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746358" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NYNRIN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79", "locus": { "chromosome": "10", "start_pos": 20755336, "end_pos": 20776156, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007149", "url": "https://www.ensembl.org/id/ENSBTAG00000007149" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007149", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007149", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18728", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18728", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22477", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22477", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516993", "url": "https://www.ncbi.nlm.nih.gov/gene/516993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516993", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYTHMAV", "url": "https://omabrowser.org/oma/group/PYTHMAV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MX66", "url": "https://www.orthodb.org/?gene=F1MX66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12876:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12876:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11977", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11977", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17919", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17919", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23050", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23050", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059746358", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746358", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX66", "url": "https://www.uniprot.org/uniprotkb/F1MX66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX66-1", "url": "https://www.uniprot.org/uniprotkb/F1MX66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRYWAIPCLSTSAALGPSLWFLLSFLPHPSLACHFSPSSVLRKALRCASPQEPSLTRARIYSLFLHRGSNLRSGISVACAAYLFVLHPEAGRPRSFCLHEYLKGLCNPELWKEVRYPAALHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDIIQWLSRIGTSDSRSDSELLICPTHQQKEGPTMVAVGDGPGPFVEMGSPENSKRLTSLGATGALISGTPGLSTQQETANQLVRVTSNNQGGVDCAREEGSVQASSSQDSVDHTQASSQQRQVRRGEDKLPLQPPVSALSVCSPWKAWTPGPTFAPMWPGAIAATFWRINELHSLHLAWLLSQACFSFPFWQRPLGPIQFKLPGQNPLPLNLGWKQKELVPLPSVESPDCTPDGGPGGEAALQNCPRPETPKKVMSLLVVSGGSGVKDKSIPGLPQIGPPLTSTPQLQARSELGDQGSVQWDCKGPEEGPVPAPPTGQGVPAAQGGLTAPSGPDSKTVPETLKVPMAAAVPTAQTPPTNPVLPAAPKVPETQMMVAAHEERAASEVPSVPTKPEAQVVPTAQKAAVGEPAPAAPHTPTAQKRQAAKTSPAGPQTSRAQTGPAPKTGPTAPKVPAAPQTSRTPKTPAAQKAPAGPGSTLDASKLLSESQPPSRGSASFLKGQGQPGSQGLQCSGTLAPSSKRQPQVEGLLGAGEGTPRQPTRHPQASNTVTSFQRYHEALNTPFELDLSEEPGNPELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREVTVFIPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQLHVLMNNSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASISELRDDTDPGPPESLQNVEEIREEQEEEERQDEEQREEQEMQKPAEEEEEDLDSSLMSVFKAECPSLSEEILRCLSLHDPQDEALDIDLQPAVASPSLGIPWDGKAPCQQVLAQLAQLTIPSNFTALSFFMGFTDSHRDVIPDYEALVAPLHSLLKQKPDWRWELDHEKAFLALKRALVSALCLSVPNPQLPFHLEVTVSQVALTAVVYQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDTPVVLDLFYASRTSVDPEAWDGRRVAKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPTASMPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSHMPVVFLTHCNWIFSLLWELLPLWRARGFLSSDGTPLPHPSLLSYIIDLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKEGAQGGDQCWNLPNDVPAPVVTPRTVCKRPDLLALQRSDSTLADTMAKLQAGQKVSNSSPFSSAFSSLSLDKESGLLMFKGDKRPRVWVVPRQLRRDLIFAVHDGPMGAHQRPEETYRKLRLLGWWPGMQEHVRHYCRSCLFCIPRNLLGSEVKVIESLWPLRSTAPWSNLQIEVVGPVTVSEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQLLLQHVFARWGIPVRLEAAQGPQFARHVLVSCGLALGVHVASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQASPFHILTGAEERLTEPLWWEMSSANIEGLKMDLFLLQLMRELLELHWRLAEKTSEKAENRRFKRERQEKEWSVGDQVLVLSLPRNGSSAKWVGPFYIGDRLSPSLYRVWGFPTPEKLGCIYPSSLMKPFAKSVTPLSFKVLEQ", "length": 1921, "header": "tr|A0AAA9ST79-1|A0AAA9ST79_BOVIN Isoform 1 of NYN domain and retroviral integrase containing OS=Bos taurus OX=9913 GN=NYNRIN PE=4 SV=1 CANONICAL=A0AAA9ST79-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79/entry#A0AAA9ST79-1", "sequence": { "sequence": "MAGRYWAIPCLSTSAALGPSLWFLLSFLPHPSLACHFSPSSVLRKALRCASPQEPSLTRARIYSLFLHRGSNLRSGISVACAAYLFVLHPEAGRPRSFCLHEYLKGLCNPELWKEVRYPAALHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDIIQWLSRIGTSDSRSDSELLICPTHQQKEGPTMVAVGDGPGPFVEMGSPENSKRLTSLGATGALISGTPGLSTQQETANQLVRVTSNNQGGVDCAREEGSVQASSSQDSVDHTQASSQQRQVRRGEDKLPLQPPVSALSVCSPWKAWTPGPTFAPMWPGAIAATFWRINELHSLHLAWLLSQACFSFPFWQRPLGPIQFKLPGQNPLPLNLGWKQKELVPLPSVESPDCTPDGGPGGEAALQNCPRPETPKKVMSLLVVSGGSGVKDKSIPGLPQIGPPLTSTPQLQARSELGDQGSVQWDCKGPEEGPVPAPPTGQGVPAAQGGLTAPSGPDSKTVPETLKVPMAAAVPTAQTPPTNPVLPAAPKVPETQMMVAAHEERAASEVPSVPTKPEAQVVPTAQKAAVGEPAPAAPHTPTAQKRQAAKTSPAGPQTSRAQTGPAPKTGPTAPKVPAAPQTSRTPKTPAAQKAPAGPGSTLDASKLLSESQPPSRGSASFLKGQGQPGSQGLQCSGTLAPSSKRQPQVEGLLGAGEGTPRQPTRHPQASNTVTSFQRYHEALNTPFELDLSEEPGNPELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREVTVFIPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQLHVLMNNSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASISELRDDTDPGPPESLQNVEEIREEQEEEERQDEEQREEQEMQKPAEEEEEDLDSSLMSVFKAECPSLSEEILRCLSLHDPQDEALDIDLQPAVASPSLGIPWDGKAPCQQVLAQLAQLTIPSNFTALSFFMGFTDSHRDVIPDYEALVAPLHSLLKQKPDWRWELDHEKAFLALKRALVSALCLSVPNPQLPFHLEVTVSQVALTAVVYQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDTPVVLDLFYASRTSVDPEAWDGRRVAKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPTASMPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSHMPVVFLTHCNWIFSLLWELLPLWRARGFLSSDGTPLPHPSLLSYIIDLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKEGAQGGDQCWNLPNDVPAPVVTPRTVCKRPDLLALQRSDSTLADTMAKLQAGQKVSNSSPFSSAFSSLSLDKESGLLMFKGDKRPRVWVVPRQLRRDLIFAVHDGPMGAHQRPEETYRKLRLLGWWPGMQEHVRHYCRSCLFCIPRNLLGSEVKVIESLWPLRSTAPWSNLQIEVVGPVTVSEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQLLLQHVFARWGIPVRLEAAQGPQFARHVLVSCGLALGVHVASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQASPFHILTGAEERLTEPLWWEMSSANIEGLKMDLFLLQLMRELLELHWRLAEKTSEKAENRRFKRERQEKEWSVGDQVLVLSLPRNGSSAKWVGPFYIGDRLSPSLYRVWGFPTPEKLGCIYPSSLMKPFAKSVTPLSFKVLEQ", "length": 1921, "header": "tr|A0AAA9ST79-1|A0AAA9ST79_BOVIN Isoform 1 of NYN domain and retroviral integrase containing OS=Bos taurus OX=9913 GN=NYNRIN PE=4 SV=1 CANONICAL=A0AAA9ST79-1" }, "locus": { "chromosome": "10", "start_pos": 20775539, "end_pos": 20757179, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124336.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124336.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089626.1" } ] } }, { "isoform_ac": "F1MX66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79/entry#F1MX66-1", "sequence": { "sequence": "MLLSGGDPPAQEWFMVQTKSKPRVQRQRQQVQRIFRVKLNAFQSRPDTPYFWLQLEGPRENMGKAKEYLKGLCNPELWKEVRYPAALHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFVMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDIIQWLSRIGTSDSRSDSELLICPTHQQKEGPTMVAVGDGPGPFVEMGSPENSKRLTSLGATGALISGTPGLSTQQETANQLVRVTSNNQGGVDCAREEGSVQASSSQDSVDHTQASSQQRQVRRGEDKLPLQPPVSALSVCSPWKAWTPGPTFAPMWPGAIAATFWRINELHSLHLAWLLSQACFSFPFWQRPLGPIQFKLPGQNPLPLNLGWKQKELVPLPSVESPDCTPDGGPGGEAALQNCPRPETPKKVMSLLVVSGGSGVKDKSIPGLPQIGPPLTSTPQLQARSELGDQGSVQWDCKGPEEGPVPAPPTGQGVPAAQGGLTAPSGPDSKTVPETLKVPMAAAVPTAQTPPTNPVLPAAPKVPETQMMVAAHEERAASEVPSVPTKPEAQVVPTAQKAAVGEPAPAAPHTPTAQKRQAAKTSPAGPQTSRAQTGPAPKTGPTAPKVPAAPQTSRTPKTPAAQKAPAGPGSTLDASKLLSESQPPSRGSASFLKGQGQPGSQGLQCSGTLAPSSKRQPQVEGLLGAGEGTPRQPTRHPQASNTVTSFQRYHEALNTPFELDLSEEPGNPELRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREVTVFIPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQLHVLMNNSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASISELRDDTDPGPPESLQNVEEIREEQEEEERQDEEQREEQEMQKPAEEEEEDLDSSLMSVFKAECPSLSEEILRCLSLHDPQDEALDIDLQPAVASPSLGIPWDGKAPCQQVLAQLAQLTIPSNFTALSFFMGFTDSHRDVIPDYEALVAPLHSLLKQKPDWRWELDHEKAFLALKRALVSALCLSVPNPQLPFHLEVTVSQVALTAVVYQEHSGRKHPVAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRYIGDTPVVLDLFYASRTSVDPEAWDGRRVAKAWLIRWALLVQDKGKRALELTLLQGLLGKNRLLTPTASMPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSHMPVVFLTHCNWIFSLLWELLPLWRARGFLSSDGTPLPHPSLLSYIIDLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKEGAQGGDQCWNLPNDVPAPVVTPRTVCKRPDLLALQRSDSTLADTMAKLQAGQKVSNSSPFSSAFSSLSLDKESGLLMFKGDKRPRVWVVPRQLRRDLIFAVHDGPMGAHQRPEETYRKLRLLGWWPGMQEHVRHYCRSCLFCIPRNLLGSEVKVIESLWPLRSTAPWSNLQIEVVGPVTVSEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQLLLQHVFARWGIPVRLEAAQGPQFARHVLVSCGLALGVHVASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSSQASPFHILTGAEERLTEPLWWEMSSANIEGLKMDLFLLQLMRELLELHWRLAEKTSEKAENRRFKRERQEKEWSVGDQVLVLSLPRNGSSAKWVGPFYIGDRLSPSLYRVWGFPTPEKLGCIYPSSLMKPFAKSVTPLSFKVLEQ", "length": 1886, "header": "tr|F1MX66-1|F1MX66_BOVIN Computationally mapped isoform of NYN domain and retroviral integrase containing OS=Bos taurus OX=9913 GN=NYNRIN PE=4 SV=3 CANONICAL=A0AAA9ST79-1" }, "locus": { "chromosome": "10", "start_pos": 20775869, "end_pos": 20757179, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009407.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009407.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009407.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009407.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 683, "start_aa": "Thr", "end_pos": 683, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr683", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516993", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516993", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QEL3-1", "protein_name": "NYN domain and retroviral integrase containing", "gene_name": "NYNRIN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLSGGDPPAQEWFMVQTKSKPRVQRQRLQVQRIFRVKLNAFQSRPDTPYFWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPAALHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQYAGDLLQLPPAVQELLLSLVRDAAGKEDIIQWLGRIGSSDSRSDPEQLLICPTPQQKEGPAMVSVGDGTGPFLEMGSPENSKKLTSLGAMGALTSGLPGRNTQPRASSNNQGGMDSAHEAGPVQASSSQDPVDHTQALSQQRQVRRGEDKLPLQPPVSALGVCSPWKAWTPGPAFGPLWPGAIAATFWRINELHSLHLAWLLSQACFSFPFWQRPLGPIQFKLPGQNPLPLNLEWKQKELVPLPSVEGPDCRPDGGPGGETALQNCPRPETPNNVMSLLVVSGGSGVKDKANPALPQIGPPLTSAPQLQARSEPGDQGSMQWDNKRPEEGPFPVMPTGQGVPTAQGRPKAQGGLAAPVGPDPKTVPETCKVPMAAAMPTAQTPPANPALPAPPKVPATQMMPAVHEEPAAPKVPLAPMKPAAQVLPTAQKAVVGRLAPAAQMVPAAPKTPTVQKRPAAKTSPAGPQTPRAQTGPVAKPGSTAPKTPTAPKAPAAPKAPAAPKTSRAPKTPTAQKAPTDPGPTLDVAKLLSEGQPSSKGRASFLKSQGEPGRQGPPSSGTLAPSSKGQPQVEGFLGAWEGAPRQPPRHPQANSTVTSFQRYHEALNTPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREVTVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGVIVTNEQLHVLMNNSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASLSEPVDEADPWPPESLQSVKEVREEKEERQDEEQREEQETQKLEEDDDQDSLLVSVFRAECPSLSEEILRCLSLHDPMDEALDIDLLPVVASPSLDIPWDGKAPCQQVLAHLAQLTIPSNFTALSFFVGFMDSHRDVIPDYEALVGPLHSLLKQKPDWQWALEHEKAFLALKRALVSALCLSAPNSQLPFRLEVTVSQVALMAVVYQEHSGRKHPVAYTSKPLLPDEESAGPQSGGDSPYAVAWALKYFSRCIGDTPVVLGLSYASRTTADPEAWDGRRLAKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPAASMPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGRSHLPVVFLTHCNWIFSLLWELLPLWRARGFLSSDGAPLPHPGLLSYIIALVSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGSGQWWHLPNDVPVPVVTRRTAGKKPDLLALQRSDSTLADIIAKLQAGQKLPNSSPFSSAFNSLSLDRESGLLMFKGDKKPRVWVVPRQLRRDLIFAVHDLPMGGHQRPEETFKKLRLLGWWPGMQEHVREYCRSCLYCIPRNLTGSELKVIESLWPLRSTAPWSNLQIEVVGPVTVSEEGHKHVLIVADPNTRWVEAFPLKPYTHMAVAQVLLQHVFARWGVPVRLEAAQGPHFARHVLVSCGLALGAQVASPSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSGLATPFQILTGGEERLTEPLWWEMSSANIEGLKMDVFLLQLMGELLELHWRVAEKASEKAENRRFKRESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRVWGFPTPEKLGCIYPSSLMKTFAKSGTPLSFKVLEQ", "length": 1900 }, "evidence": [ { "id": "A0AAA9ST79", "url": "https://omabrowser.org/oma/group/A0AAA9ST79/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0RAC3-1", "protein_name": "NYN domain and retroviral integrase containing", "gene_name": "Nynrin", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLSGGKPPAQEWFMVQTKSKPRVHRQRLQVQRIFRVKVTAFQSRPDTPYFWLQLEGPRENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMITPRGVWETEVTRAFGALVWIRCDQYARDLLQLPPAVQELLLSLVRDAAGKEDIIEWLGHFGISGIYPKPPDFLICPALQKKEGSSLVTIGESPVPLQEIGTLNRASENSKKLTGLGAAGSVVPAQSTPQDTAQQLVRDGSNKQGDDRNSAGEEGATAQDSAGEEGATAQDPSSQDSANHTQALLQQKQGQKTENRISLQSPALSVCPSWKAWAPGPAFGPSWPGTIAATFWKINELQSLHLVWLLSQACFNFPFWQRPVGPIQLRLPGQNPLPLKLEWKQKELVPLPTAESPACRPDGDLGREAALKHSLRPETPTKIISLSVVPGDCGIKEKVSPGLSQVGPSSTSIPQAGVELGDEGRALSDCKGPEKLSSSALSTEQGGPRIQERPMAQAGMTGQSVPDTPTMSETLEVTTAAAVSKVECTPTEGLPATPKVPTTLKKPAVYTEPTAPQVPSAPTEPAAPVVSTIPKAAVDQPAAPATPTTPQTPTAQKTPSVKTPAGPQTPKVQTGIIAKAESTAPKAPAATQAPAASNASSVSKTPEAQASAIAGPTMDVTKLLSEEVQASKCRATVLKGQGKPGRQGLQSSSTMASRSKHQFLKEGLLGAWDGTQRLSPHSQGTNIVTSFQRFNEALNTPFEMNLSEEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREITVFVPTWQLKKNRRVRESHFLTKLHRLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGVIVTNEQIHILMNNSKKLMVKDRLLPFTFAGSLFMVPDDPLGRDGPTLEEFLKKPNRLDMDIGNFLKVWKTLPPSSASISELGDAADAEPLEGPQNIEEGEKGEESLEEELVEEPGIPKPDEQEEQDSDPVSVFGVECPSFSEEILQCLSLHDPSEGALDIDLLPVVSSPYLDVPWDGKAPSQQVLTQLAQLTIPSNFTALSFFMGFMDSHRDVIPDYEVLVGPLHSLLKQKPDWQWNQEHEKSFLALKRALVCALCLSTPNPDLPFYLEVTVSQVSLTASLHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFSRCVGDNPVVLRLSYASRTTVDNEAWDSRRASNAWLIRWSLLLQDKGKRELELSLLQGLLGENQLLTPASSMPRVFQLLPPSSDLSTFICVHVSGYCFYHDDELCAGFGLYILSPTSPPVSLAFSCSPYTSTYAHLAGVACGLERFGQSQLPVVFVTHCNWIFSVLWEFLPLWKVRGFLSSDGASLPHPSLLSYIISLTSCFSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPKDVPVPIVTPHTKGRKPNLLALQMSDSTLANIIAKLQAGQKLSGPSPFSSAFNSLSLDQDSGLLMFKAEKHPRVWVVPRQLRRDLIFSVHDSPMGDHQGPEDTYKTLRLLGWWPGMQDHVKDYCRSCLFCIPRNLIGGELKVIESPWPLRSTAPWSSLQIEVVGPVTVSEEGHKHVLIVADANTRWVEAFPLKPYTHVAVAQVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQVTTLSRSLQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPFQVLTGGEMRLMEPSWWEMSRANIEGLKMDAFLLQLIRELLDLHWRVAEKASEKAENRRFKRESRESEWSVGDQVLLLSLPRNGSSAKWMGPFYIGDRLSLSLYRVWGFPVPDKLGCVYPSSLMKAFPKNDTPLPLDLEQ", "length": 1903 }, "evidence": [ { "id": "A0AAA9ST79", "url": "https://omabrowser.org/oma/group/A0AAA9ST79/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5DTZ0-1", "protein_name": "Protein NYNRIN", "gene_name": "Nynrin", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLSGGKPPAQEWFMVQTKSKPRVHRQRLQVQRIFRVKVTAFQSRPDTPYFWLQLEGPRENTGKAKEYLKGLCNPELWKEVRYPPVLHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFTMTQNWLEELVARLRWGPAPMITPRGVWETEVTRAFGALVWIRCDKYAGDLLQLPPAVQELLLSLVRDAAGKEDIIEWLGHFGISGTCPNPEILICLARQQKESASLVTIKESPGTLQEIGALNRASENSKKTTSSGAAGSLTQAQSPPAQETADQLARDQSNKQGDETNSVGEEGTATQDTSSQDSENPTQALLQQKQVPKNEERISLLLPVSALSAYTSWKVWAPGTAFGPSWPGTIAATFWKINELQSLHLAWLLSQACLNFPFWQRPTGPIQLKLPGRNPLPLKLEWKQKELVPLSSAGSPACRPGGDLGRETALKHSPRPEIPSKIISLSVVPGGCGIKEKVSPGLLQVGQSSTSVGDKGISLSDCKGLEKPFSLALSTEQGGSTAQERPLAQVPEAPTVSETLQVATAAEVSNVEHPPTGEGLPATPKVPTALKKPAVYTEPTAPKVPSAPTEPAAPATPTAPQTPTAQKTPSVKTLAGLQTPKVQSETIATAGSEVPKAPAASAVAGPTVDVAQLLSEVQASKNRAIMLKVQGKPGRQGFQPSSTVPSRSKHQFLKEGLLGAWEGSQRLSPHSQGTNIVTSFQRYNEALNTPFEMNLSEEPGNPGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQYFWNRGHREITVFVPTWQLKKNRRVRESHFLTKLHRLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGVIVTNEQIHILMNNSKKLMVKDRLLPFTFAGSLFMVPDDPLGRDGPTLEEFLKKPNRLDMDIGNFLKVWKTLPPSSASISELSDDADAEPLEDPQDVEEAGKEEGSLEEEPGIPKPDEEDEQDTNPVSVFGVECPSFSEEILQCLSLHDPSEGTLDIDLLPVVSSPYLDVPWDGKAPCQQVLAQLAQLNIPSNFTALSFFMGFMDSHRDVISDYEDLVGPLHGLLKQKPDWQWNQEHEKSFLALKRALVCALCLSTPNPNLPFYLEVTVSQVSLTASLHQEHSGRKHPIAYTSKPLLPDEDSEGPQSGGDSPYAVAWALKHFARCVGDNPVVLRLSYASRTTVDNEAWDSRRASKAWLIRWSLLLQDKGKRELELSLLQGLLGENQLLTPPSSMPRVFQPLPPSSDLSTFICVHVSGYCFYRDDELCAGFGLYILSPTSPPVSLAFSCSPYTTTYAHLAAVACGLERFGQSQHPVVFLTHCNWIFSVLWELLPLWRVRGFLSSDGASLPHPSLLSYIISLTSGFSPLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWDLPKDVPVPMVTPHPKGRKPNLLALQLSDTTLADIIAKLQAGQKLSGPSPFSSAFNSLSLDQDSGLLMFKGERHPRVWVVPRQLRRDLIFSVHDSPIGEHQGLEDTYKTVRLLGWWPGMQDHVRDYCRSCLFCIPRNLIGGELKVIESPWPLRSTAPWSSLQIEVVGPVTVSEEGHKHVLIVADANTRWVEAFPLKPYTHVAVAQVLLQHVFARWGVPIRLEAAQGPQFARHVLVSCGLALGAQVTTLSRALQFPCLMSSEAYWEFKRALKEFIFLYGKKWAASLPLLHLAFRASTTEATPFQVLTGGEMKLMEPVWWEMSRANIEGLKMDAFLLQLMRELLDLHWRVAEKASEKAENRRFKRESQENEWSVGDQVLLLSLPRNGSSAKWMGPFYIGDRLSLSLYRVWGFPVPDKLGCVYPSSLMKAFPKHDTPLSLDVEQ", "length": 1840 }, "evidence": [ { "id": "A0AAA9ST79", "url": "https://omabrowser.org/oma/group/A0AAA9ST79/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2P1-1", "protein_name": "Protein NYNRIN", "gene_name": "NYNRIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLSGGDPPAQEWFMVQTKSKPRVQRQRLQVQRIFRVKLNAFQSRPDTPYFWLQLEGPRENMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMVGGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQHAGDLLQLPPAVQELLLSLVRDAAGKEDIIEWLSRFGISDSHSDPEVLICPPQQQKEAPAMVSVGESPGPFVDMGTLQNRGPENSKRLSSLGATGSLITAQSTPQEAANQLVRVGSNNQDGMDSAQEEGTVQATSSQDSTNHTQALLKQRQVQKIEDKLLFQPPVSALGVCPPWKAWTPGPAFGPLWPGAIAATFWRINELHSLHLAWLLSQACFNFPFWQRPLGPIQLKLPGQNPLPLNLEWKQKELAPLPSAESPAGRPDGGLGGEAALQNCPRPEISPKVTSLLVVPGSSDVKDKVSSDLPQIGPPLTSTPQLQAGGEPGDQGSMQLDFKGLEEGPAPVLPTGQGKPVAQGGLTDQSVPGAQTVPETLKVPMAAAVPKAENPSRTQVPSAAPKLPTSRMMLAVHTEPAAPEVPLAPTKPTAQLMATAQKTVVNQPVLVAQVEPTTPKTPQAQKMPVAKTSPAGPKTPKAQAGPAATVSKAPAASKAPAAPKVPVTPRVSRAPKTPAAQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQAGRQGPQSSGTLALSSKHQFQMEGLLGAWEGAPRQPPRHLQANSTVTSFQRYHEALNTPFELNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREVTVFVPTWQLKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQIHILMNSSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKVWKTLPPSSASVTELSDDADSGPLESLPNMEEVREEKEERQDEEQRQGQGTQKAAEEDDLDSSLASVFRVECPSLSEEILRCLSLHDPPDGALDIDLLPGAASPYLGIPWDGKAPCQQVLAHLAQLTIPSNFTALSFFMGFMDSHRDAIPDYEALVGPLHSLLKQKPDWQWDQEHEEAFLALKRALVSALCLMAPNSQLPFRLEVTVSHVALTAILHQEHSGRKHPIAYTSKPLLPDEESQGPQSGGDSPYAVAWALKHFSRCIGDTPVVLDLSYASRTTADPEVREGRRVSKAWLIRWSLLVQDKGKRALELALLQGLLGENRLLTPAASMPRFFQVLPPFSDLSTFVCIHMSGYCFYREDEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSPLPVVFLTHCNWIFSLLWELLPLWRARGFLSSDGAPLPHPSLLSYIISLTSGLSSLPFIYRTSYRGSLFAVTVDTLAKQGAQGGGQWWSLPKDVPAPTVSPHAMGKRPNLLALQLSDSTLADIIARLQAGQKLSGSSPFSSAFNSLSLDKESGLLMFKGDKKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPEETYKKLRLLGWWPGMQEHVKDYCRSCLFCIPRNLIGSELKVIESPWPLRSTAPWSNLQIEVVGPVTISEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAAQGPQFARHVLVSCGLALGAQVASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAASLPLLHLAFRASSTDATPFKVLTGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLELHWRVADKASEKAENRRFKRESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSLYRIWGFPTPEKLGCIYPSSLMKAFAKSGTPLSFKVLEQ", "length": 1898 }, "evidence": [ { "id": "A0AAA9ST79", "url": "https://omabrowser.org/oma/group/A0AAA9ST79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" }, { "name": "RNA-DNA hybrid ribonuclease activity", "id": "GO:0004523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004523", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA integration", "id": "GO:0015074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015074", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA destabilization", "id": "GO:0061158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1113, "end_pos": 1115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1526, "end_pos": 1528, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1863, "end_pos": 1865, "annotation": "n_glycosylation_sequon" }, { "start_pos": 924, "end_pos": 926, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" }, { "id": "PS50994", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50994" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Integrase catalytic", "eco_id": "ECO_0000259", "start_pos": 1632, "end_pos": 1722, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9ST79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST79" }, { "id": "PS50879", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50879" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RNase H type-1", "eco_id": "ECO_0000259", "start_pos": 1327, "end_pos": 1473, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 683 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1113, "end_pos": 1115 }, { "start_pos": 1526, "end_pos": 1528 }, { "start_pos": 1863, "end_pos": 1865 }, { "start_pos": 924, "end_pos": 926 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9ST90-1", "uniprot_ac": "A0AAA9ST90", "uniprot_id": "A0AAA9ST90_BOVIN", "mass": { "chemical_mass": 139964.0, "monoisotopic_mass": 139964.0 }, "refseq": { "ac": "XP_024849590", "name": "AP-3 complex subunit delta-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849590" }, "gene_names": [ { "name": "AP3D1", "type": "recommended", "evidence": [ { "id": "A0AAA9ST90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ] }, { "name": "AP3D1", "type": "synonym", "evidence": [ { "id": "XP_024849590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849590" } ] }, { "name": "BLVR", "type": "synonym", "evidence": [ { "id": "XP_024849590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849590" } ] } ], "protein_names": [ { "name": "AP-3 complex subunit delta-1", "type": "recommended", "evidence": [ { "id": "A0AAA9ST90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#names_and_taxonomy" } ] }, { "name": "AP-3 complex subunit delta-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024849590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849590" } ] }, { "name": "AP-3 complex subunit delta", "type": "synonym", "evidence": [ { "id": "A0AAA9ST90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#names_and_taxonomy" } ] }, { "name": "Adaptor-related protein complex 3 subunit delta-1", "type": "synonym", "evidence": [ { "id": "A0AAA9ST90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#names_and_taxonomy" } ] }, { "name": "Delta-adaptin", "type": "synonym", "evidence": [ { "id": "A0AAA9ST90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90#function" }, { "database": "UniProtKB", "id": "ARBA00055970", "url": "https://www.uniprot.org/uniprotkb/ARBA00055970#function" }, { "database": "UniProtKB", "id": "A0AAA9TY90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY90#function" }, { "database": "UniProtKB", "id": "A0AAF6YT68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP3D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90", "locus": { "chromosome": "7", "start_pos": 21463304, "end_pos": 21413939, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009034", "url": "https://www.ensembl.org/id/ENSBTAG00000009034" } ] } } ], "crossref": [ { "id": "A0AAA9ST90", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9ST90", "database": "AlphaFoldDB", "categories": [] }, { "id": "281023", "url": "https://www.ncbi.nlm.nih.gov/gene/281023", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017105", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017105", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22781", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22781", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22781:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22781:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06375", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06375", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024849590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YT68", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YT68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YT68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCLWYLLLKRDAEPPAPPQALDSLLGDPPLLRAAPGGNPFWDKRTSRLLPGVWSGIGLASWARVPQKAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILRTHPKSVQAHKDLVLQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRRFAVAQMSALLDSAHLVASSPQRSGICEVLYAAAWICGEFSEHLQEPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYAAILQQKEQAADTSAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDEKPKAMFQDEEQRHTKPRAPEADEQELARRREARRQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPLSDQYVKLEEERRHRQRLEKDKRKKKKRERERRGTRRHSSLHTESDEDIAPAQRVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAETSKSPEKEDVPLVEKKSKKPKKKEKKHKEKEREKKKKEVEKGEDLDFWLSTTPPAATPALEELEVNTTVTVLKEGQEEPRGEEQDAEEDREQDLEKKPSKHKKKKHKKDKEERPKDKRKSKKKVPPADEEAAEPVENGTLEEEPLPPMSSYILLAENSYIKMTYDVQGSLQKDSQVTVSVVLENQSDSFLKSMELNVLDSLNARLARPEGSSVHDGVPVPFQLPPGISNEAQFVFTIQSIVMAQKLKGTLSFIAKNDEGSTHEKLDFKLHFTCTSYLVTTPCYSDAFAKLLESGDLSMSSIKVDGISMSFHNLLAKICFHHRFSVVERVDSCASMYSRSIQGHHVCLLVKKGEKSVSVDGKCSDPTLLSNLLEEMKETLATC", "length": 1242, "header": "tr|A0AAA9ST90-1|A0AAA9ST90_BOVIN Isoform 1 of AP-3 complex subunit delta-1 OS=Bos taurus OX=9913 GN=AP3D1 PE=3 SV=1 CANONICAL=A0AAA9ST90-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#A0AAA9ST90-1", "sequence": { "sequence": "MCLWYLLLKRDAEPPAPPQALDSLLGDPPLLRAAPGGNPFWDKRTSRLLPGVWSGIGLASWARVPQKAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILRTHPKSVQAHKDLVLQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRRFAVAQMSALLDSAHLVASSPQRSGICEVLYAAAWICGEFSEHLQEPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYAAILQQKEQAADTSAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDEKPKAMFQDEEQRHTKPRAPEADEQELARRREARRQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPLSDQYVKLEEERRHRQRLEKDKRKKKKRERERRGTRRHSSLHTESDEDIAPAQRVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAETSKSPEKEDVPLVEKKSKKPKKKEKKHKEKEREKKKKEVEKGEDLDFWLSTTPPAATPALEELEVNTTVTVLKEGQEEPRGEEQDAEEDREQDLEKKPSKHKKKKHKKDKEERPKDKRKSKKKVPPADEEAAEPVENGTLEEEPLPPMSSYILLAENSYIKMTYDVQGSLQKDSQVTVSVVLENQSDSFLKSMELNVLDSLNARLARPEGSSVHDGVPVPFQLPPGISNEAQFVFTIQSIVMAQKLKGTLSFIAKNDEGSTHEKLDFKLHFTCTSYLVTTPCYSDAFAKLLESGDLSMSSIKVDGISMSFHNLLAKICFHHRFSVVERVDSCASMYSRSIQGHHVCLLVKKGEKSVSVDGKCSDPTLLSNLLEEMKETLATC", "length": 1242, "header": "tr|A0AAA9ST90-1|A0AAA9ST90_BOVIN Isoform 1 of AP-3 complex subunit delta-1 OS=Bos taurus OX=9913 GN=AP3D1 PE=3 SV=1 CANONICAL=A0AAA9ST90-1" }, "locus": { "chromosome": "7", "start_pos": 21446253, "end_pos": 21414358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090802.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090802.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086268.1" } ] } }, { "isoform_ac": "A0AAA9TY90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#A0AAA9TY90-1", "sequence": { "sequence": "MLGCRAASCPGDRPRQPEELMARADSGSGPWPPEGRLGSWTQMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILRTHPKSVQAHKDLVLQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRRFAVAQMSALLDSAHLVASSPQRSGICEVLYAAAWICGEFSEHLQEPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYAAILQQKEQAADTSAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDEKPKAMFQDEEQRHTKPRAPEADEQELARRREARRQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPLSDQYVKLEEERRHRQRLEKDKRKKKKRERERRGTRRHSSLHTESDEDIAPAQRVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAETSKSPEKEDVPLVEKKSKKPKKKEKKHKEKEREKKKKEVEKGEDLDFWLSTTPPAATPALEELEVNTTVTVLKEGQEEPRGEEQDAEEDREQDLEKKPSKHKKKKHKKDKEERPKDKRKSKKKVPPADEEAAEPVENGTLEEEPLPPMSSYILLAENSYIKMTYDVQGSLQKDSQVTVSVVLENQSDSFLKSMELNVLDSLNARLARPEGSSVHDGVPVPFQLPPGISNEAQFVFTIQSIVMAQKLKGTLSFIAKNDEGSTHEKLDFKLHFTCTSYLVTTPCYSDAFAKLLESGDLSMSSIKVDGISMSFHNLLAKICFHHRFSVVERVDSCASMYSRSIQGHHVCLLVKKGEKSVSVDGKCSDPTLLSNLLEEMKETLATC", "length": 1095, "header": "tr|A0AAA9TY90-1|A0AAA9TY90_BOVIN Computationally mapped isoform of AP-3 complex subunit delta-1 OS=Bos taurus OX=9913 GN=AP3D1 PE=3 SV=1 CANONICAL=A0AAA9ST90-1" }, "locus": { "chromosome": "7", "start_pos": 21446253, "end_pos": 21429479, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090938.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090938.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103323.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103323.1" } ] } }, { "isoform_ac": "A0AAF6YT68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90/entry#A0AAF6YT68-1", "sequence": { "sequence": "MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHRVAHGPAPTGPRVPGRCGLLPGPITWALTQWSVSVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILRTHPKSVQAHKDLVLQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRRFAVAQMSALLDSAHLVASSPQRSGICEVLYAAAWICGEFSEHLQEPQQTLEAMLRPKVTTLPGHIQAVYVQNVVKLYAAILQQKEQAADTSAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDEKPKAMFQDEEQRHTKPRAPEADEQELARRREARRQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVVQIDLSVPLKVPGMPLSDQYVKLEEERRHRQRLEKDKRKKKKRERERRGTRRHSSLHTESDEDIAPAQRVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAETSKSPEKEDVPLVEKKSKKPKKKEKKHKEKEREKKKKEVEKGEDLDFWLSTTPPAATPALEELEVNTTVTVLKEGQEEPRGEEQDAEEDREQDLEKKPSKHKKKKHKKDKEERPKDKRKSKKKVPPADEEAAEPVENGTLEEEPLPPMSSYILLAENSYIKMTYDVQGSLQKDSQVTVSVVLENQSDSFLKSMELNVLDSLNARLARPEGSSVHDGVPVPFQLPPGISNEAQFVFTIQSIVMAQKLKGTLSFIAKNDEGSTHEKLDFKLHFTCTSYLVTTPCYSDAFAKLLESGDLSMSSIKVDGISMSFHNLLAKICFHHRFSVVERVDSCASMYSRSIQGHHVCLLVKKGEKSVSVDGKCSDPTLLSNLLEEMKETLATC", "length": 1224, "header": "tr|A0AAF6YT68-1|A0AAF6YT68_BOVIN Computationally mapped isoform of AP-3 complex subunit delta OS=Bos taurus OX=9913 GN=AP3D1 PE=3 SV=1 CANONICAL=A0AAA9ST90-1" }, "locus": { "chromosome": "7", "start_pos": 21446253, "end_pos": 21413969, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011906.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011906.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011906.5", "url": "https://www.ensembl.org/id/ENSBTAP00000011906.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 917, "start_aa": "Thr", "end_pos": 917, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr917", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" }, { "name": "AP-3 adaptor complex", "id": "GO:0030123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" }, { "name": "lysosomal transport", "id": "GO:0007041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1044, "end_pos": 1046, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 926, "end_pos": 928, "annotation": "n_glycosylation_sequon" }, { "start_pos": 997, "end_pos": 999, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9ST90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST90" }, { "id": "SM01354", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01354" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AP-3 complex subunit delta", "eco_id": "ECO_0000259", "start_pos": 695, "end_pos": 842, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 917 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1044, "end_pos": 1046 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 926, "end_pos": 928 }, { "start_pos": 997, "end_pos": 999 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STA1-1", "uniprot_ac": "A0AAA9STA1", "uniprot_id": "A0AAA9STA1_BOVIN", "mass": { "chemical_mass": 35707.0, "monoisotopic_mass": 35707.0 }, "refseq": { "ac": "NP_001377693", "name": "olfactory receptor family 52 subfamily N member 1C", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377693" }, "gene_names": [ { "name": "OR52N1C", "type": "recommended", "evidence": [ { "id": "A0AAA9STA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1" } ] }, { "name": "OR52N1C", "type": "synonym", "evidence": [ { "id": "NP_001377693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377693" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9STA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 52 subfamily N member 1C", "type": "synonym", "evidence": [ { "id": "NP_001377693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377693" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377693" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52N1C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1", "locus": { "chromosome": "15", "start_pos": 47369562, "end_pos": 47370521, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061132", "url": "https://www.ensembl.org/id/ENSBTAG00000061132" } ] } } ], "crossref": [ { "id": "A0AAA9STA1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "112441464", "url": "https://www.ncbi.nlm.nih.gov/gene/112441464", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112441464", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441464", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLLNDTSLTPVSFILNGIPGLEEVHLWVSFPLCTMYSIAITGNFGLMYLIYSEEALHRPMHIFLALLSFTDVLMCTSTLPNTLCILWFNLKEIDFKACLAQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATVLTNSVIAKAGLLTFLRGVMLVIPFTFLTKRLPYCRGNVILHTYCDHMSVAKISCGNVKVNAIYGLMVALLIGGFDILCITVSYTMILQAVVSLSSAEARQKAFSTCTAHIFAIVITYVPAFFTFFTHRFGGRSIPPHIHIIMANLLMPPTMNPIVYGIKTKQIRTCITRFLLKGKDNPSHNI", "length": 319, "header": "tr|A0AAA9STA1-1|A0AAA9STA1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52N1C PE=3 SV=1 CANONICAL=A0AAA9STA1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1/entry#A0AAA9STA1-1", "sequence": { "sequence": "MLLLNDTSLTPVSFILNGIPGLEEVHLWVSFPLCTMYSIAITGNFGLMYLIYSEEALHRPMHIFLALLSFTDVLMCTSTLPNTLCILWFNLKEIDFKACLAQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATVLTNSVIAKAGLLTFLRGVMLVIPFTFLTKRLPYCRGNVILHTYCDHMSVAKISCGNVKVNAIYGLMVALLIGGFDILCITVSYTMILQAVVSLSSAEARQKAFSTCTAHIFAIVITYVPAFFTFFTHRFGGRSIPPHIHIIMANLLMPPTMNPIVYGIKTKQIRTCITRFLLKGKDNPSHNI", "length": 319, "header": "tr|A0AAA9STA1-1|A0AAA9STA1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52N1C PE=3 SV=1 CANONICAL=A0AAA9STA1-1" }, "locus": { "chromosome": "15", "start_pos": 47370521, "end_pos": 47369565, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101623.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101623.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089648.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089648.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112441464", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441464", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 293, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STC1-1", "uniprot_ac": "A0AAA9STC1", "uniprot_id": "A0AAA9STC1_BOVIN", "mass": { "chemical_mass": 17242.0, "monoisotopic_mass": 17242.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "60S ribosomal protein L27", "type": "recommended", "evidence": [ { "id": "A0AAA9STC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1", "locus": {} } ], "crossref": [ { "id": "A0AAA9STC1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001141", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001141", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "XKRIERR", "url": "https://omabrowser.org/oma/group/XKRIERR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10497", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10497", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSX2", "url": "https://www.uniprot.org/uniprotkb/F1MSX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSX2-1", "url": "https://www.uniprot.org/uniprotkb/F1MSX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVALYHDSTLRDCCQNGQVHDTQNVMLVLAGHYSERKAVIMKNIDDGTSGRIYNHVLVAGIDCYSCKVTSAIGKKKTAKKSKIKSSAKVYHSNQLRPTNYSVDNPLDKAVVNEDIFREPVVKRKAKREAKFKSEERYKTGKNRWFSQKLQF", "length": 151, "header": "tr|A0AAA9STC1-1|A0AAA9STC1_BOVIN Isoform 1 of 60S ribosomal protein L27 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9STC1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1/entry#A0AAA9STC1-1", "sequence": { "sequence": "MVALYHDSTLRDCCQNGQVHDTQNVMLVLAGHYSERKAVIMKNIDDGTSGRIYNHVLVAGIDCYSCKVTSAIGKKKTAKKSKIKSSAKVYHSNQLRPTNYSVDNPLDKAVVNEDIFREPVVKRKAKREAKFKSEERYKTGKNRWFSQKLQF", "length": 151, "header": "tr|A0AAA9STC1-1|A0AAA9STC1_BOVIN Isoform 1 of 60S ribosomal protein L27 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9STC1-1" }, "locus": { "chromosome": "23", "start_pos": 10468842, "end_pos": 10466252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086306.1" } ] } }, { "isoform_ac": "F1MSX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1/entry#F1MSX2-1", "sequence": { "sequence": "MLVLAGHYSERKAVIMKNIDDGTSGRIYNHVLVAGIDCYSCKVTSAIGKKKTAKKSKIKSSAKVYHSNQLRPTNYSVDNPLDKAVVNEDIFREPVVKRKAKREAKFKSEERYKTGKNRWFSQKLQF", "length": 126, "header": "tr|F1MSX2-1|A0AAA9STC1_BOVIN Computationally mapped isoform of 60S ribosomal protein L27 OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=A0AAA9STC1-1" }, "locus": { "chromosome": "23", "start_pos": 10468842, "end_pos": 10468465, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094346.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094346.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097217.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097217.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STC2-1", "uniprot_ac": "A0AAA9STC2", "uniprot_id": "A0AAA9STC2_BOVIN", "mass": { "chemical_mass": 38154.0, "monoisotopic_mass": 38154.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100848282", "type": "recommended", "evidence": [ { "id": "A0AAA9STC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ] } ], "protein_names": [ { "name": "MHC class I-like antigen recognition-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100848282", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2", "locus": {} } ], "crossref": [ { "id": "A0AAA9STC2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007238", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007238", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675:SF64", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675:SF64", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6N1", "url": "https://www.uniprot.org/uniprotkb/G3X6N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6N1-1", "url": "https://www.uniprot.org/uniprotkb/G3X6N1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QRLTHRPGGPPGAPFPERSTSARSPSSAPARDPRSSDASPNAAGRASPEPGPRGVWPRFERAIQTQNPEGFLSLGLKTLGGARRQRYRHTPGYLLLVTLLKLQGGRSLAHTAGHLLLILLLIETGKTLGNAHSLCLDLTVKSQSRRHQPWCQVQGSVDTKPFLQYDSASNKVKPLGFLGKEVNDTKAWTEISQTLVEAGKELRMVLPVIKLDKNETRGPPTLQVKLCCQCEAEQCSGASLHFSLNGRTALLLDTMSITWTVIDPGATGIKEKWEHNQELAEYFRNISTRDCSYWLREFLKHWKMLLPEPTESLIMAPDISQSASIRLVSCIILLIITQLVLIASSS", "length": 346, "header": "tr|A0AAA9STC2-1|A0AAA9STC2_BOVIN Isoform 1 of MHC class I-like antigen recognition-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC100848282 PE=4 SV=1 CANONICAL=A0AAA9STC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2/entry#A0AAA9STC2-1", "sequence": { "sequence": "QRLTHRPGGPPGAPFPERSTSARSPSSAPARDPRSSDASPNAAGRASPEPGPRGVWPRFERAIQTQNPEGFLSLGLKTLGGARRQRYRHTPGYLLLVTLLKLQGGRSLAHTAGHLLLILLLIETGKTLGNAHSLCLDLTVKSQSRRHQPWCQVQGSVDTKPFLQYDSASNKVKPLGFLGKEVNDTKAWTEISQTLVEAGKELRMVLPVIKLDKNETRGPPTLQVKLCCQCEAEQCSGASLHFSLNGRTALLLDTMSITWTVIDPGATGIKEKWEHNQELAEYFRNISTRDCSYWLREFLKHWKMLLPEPTESLIMAPDISQSASIRLVSCIILLIITQLVLIASSS", "length": 346, "header": "tr|A0AAA9STC2-1|A0AAA9STC2_BOVIN Isoform 1 of MHC class I-like antigen recognition-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC100848282 PE=4 SV=1 CANONICAL=A0AAA9STC2-1" }, "locus": { "chromosome": "NKLS02001566.1", "start_pos": 16912, "end_pos": 13037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120898.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120898.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088600.1" } ] } }, { "isoform_ac": "G3X6N1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2/entry#G3X6N1-1", "sequence": { "sequence": "ATCAADVVLETGSAGEGAGKGGRRPLLLDSGKFVSFAGFLSLGLKTLGGARRQRYRHTPGYLLLVTLLKLQGGRSLAHTAGHLLLILLLIETGKTLGNAHSLCLDLTVKSQSRRHQPWCQVQGSVDTKPFLQYDSASNKVKPLGFLGKEVNDTKAWTEISQTLVEAGKELRMVLPVIKLDKNETRGPPTLQVKLCCQCEAEQCSGASLHFSLNGRTALLLDTMSITWTVIDPGATGIKEKWEHNQELAEYFRNISTRDCSYWLREFLKHWKMLLPEPTESLIMAPDISQSASIRLVSCIILLIITQLVLIASSS", "length": 314, "header": "tr|G3X6N1-1|G3X6N1_BOVIN Computationally mapped isoform of MHC class I-like antigen recognition-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC100848282 PE=4 SV=3 CANONICAL=A0AAA9STC2-1" }, "locus": { "chromosome": "NKLS02001566.1", "start_pos": 16490, "end_pos": 13037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009522.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009522.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009522.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009522.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "natural killer cell lectin-like receptor binding", "id": "GO:0046703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046703", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class Ib", "id": "GO:0002476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002476", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" }, { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "id": "GO:0002486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002486", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated cytotoxicity", "id": "GO:0001916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001916", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" }, { "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC2" }, { "id": "PF00129", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MHC class I-like antigen recognition-like", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 303, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 }, { "start_pos": 214, "end_pos": 216 }, { "start_pos": 285, "end_pos": 287 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STD3-1", "uniprot_ac": "A0AAA9STD3", "uniprot_id": "A0AAA9STD3_BOVIN", "mass": { "chemical_mass": 65461.0, "monoisotopic_mass": 65461.0 }, "refseq": {}, "gene_names": [ { "name": "TCERG1L", "type": "recommended", "evidence": [ { "id": "A0AAA9STD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3" } ] } ], "protein_names": [ { "name": "Transcription elongation regulator 1-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCERG1L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3", "locus": { "chromosome": "26", "start_pos": 50095362, "end_pos": 51319553, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065448", "url": "https://www.ensembl.org/id/ENSBTAG00000065448" } ] } } ], "crossref": [ { "id": "A0AAA9STD3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STD3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15377:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15377:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01846", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01846", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLVGARLQRRRRQLQHQPRRRQPLLWPMNADPPPPPPPWVWMVPGSAGLLRLGAGVAPPPVLLASAQPPAGPLLPGLPAWQAPGEPLLPLLPLPSAPDHAAAAAAAAHRYPVLNGQWLFGGHSPSIGLSPSSSVELVPIFPHVCTSALPLPVGKSWIDKRIPNCKIFLNNSLALDSTWIYPEESRLFHGPQKPQLLTNQVAVSLSRPAPASRPLPTVLIAPQPLPGGCHSSLRPLGSSPTVAVAAAATAVVSMDPEGLGGPAPSRVQPCHLLTLAPIRMPLRTAPFPDKSRERSRAPCPPALVLHAERKSPAGEGEDKEPPSILVASEDGAPEGTRPVASTPVPGSPWCVVWTGDDRVFFFNPTMQLSVWEKPMDLRNRGDLNRIIEDPPHKRKLEAAATEPSDGSSSEDSREDPDVKTKRNRTEGHVSPSAEEAERQDVGAKTPLPQILLPLEERVTHFRDMLLERGVSAFSTWEKELHKIVFDPRYLLLNSEERKQIFEQFVKTRIKEEYKEKKSKLLLAKEEFKKLLEESKLSPRTTFKEFAEKYGRDQRFRLVQKRKDQEHFFNQFILILKKRDKENRLRLRKMR", "length": 589, "header": "tr|A0AAA9STD3-1|A0AAA9STD3_BOVIN Isoform 1 of Transcription elongation regulator 1-like protein OS=Bos taurus OX=9913 GN=TCERG1L PE=4 SV=1 CANONICAL=A0AAA9STD3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3/entry#A0AAA9STD3-1", "sequence": { "sequence": "MLVGARLQRRRRQLQHQPRRRQPLLWPMNADPPPPPPPWVWMVPGSAGLLRLGAGVAPPPVLLASAQPPAGPLLPGLPAWQAPGEPLLPLLPLPSAPDHAAAAAAAAHRYPVLNGQWLFGGHSPSIGLSPSSSVELVPIFPHVCTSALPLPVGKSWIDKRIPNCKIFLNNSLALDSTWIYPEESRLFHGPQKPQLLTNQVAVSLSRPAPASRPLPTVLIAPQPLPGGCHSSLRPLGSSPTVAVAAAATAVVSMDPEGLGGPAPSRVQPCHLLTLAPIRMPLRTAPFPDKSRERSRAPCPPALVLHAERKSPAGEGEDKEPPSILVASEDGAPEGTRPVASTPVPGSPWCVVWTGDDRVFFFNPTMQLSVWEKPMDLRNRGDLNRIIEDPPHKRKLEAAATEPSDGSSSEDSREDPDVKTKRNRTEGHVSPSAEEAERQDVGAKTPLPQILLPLEERVTHFRDMLLERGVSAFSTWEKELHKIVFDPRYLLLNSEERKQIFEQFVKTRIKEEYKEKKSKLLLAKEEFKKLLEESKLSPRTTFKEFAEKYGRDQRFRLVQKRKDQEHFFNQFILILKKRDKENRLRLRKMR", "length": 589, "header": "tr|A0AAA9STD3-1|A0AAA9STD3_BOVIN Isoform 1 of Transcription elongation regulator 1-like protein OS=Bos taurus OX=9913 GN=TCERG1L PE=4 SV=1 CANONICAL=A0AAA9STD3-1" }, "locus": { "chromosome": "26", "start_pos": 51319553, "end_pos": 50095365, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111592.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111592.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087399.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase binding", "id": "GO:0070063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070063", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3" }, { "id": "PS51676", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51676" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FF", "eco_id": "ECO_0000259", "start_pos": 453, "end_pos": 506, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9STD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD3" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 346, "end_pos": 375, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 }, { "start_pos": 422, "end_pos": 424 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STD5-1", "uniprot_ac": "A0AAA9STD5", "uniprot_id": "A0AAA9STD5_BOVIN", "mass": { "chemical_mass": 66318.0, "monoisotopic_mass": 66318.0 }, "refseq": {}, "gene_names": [ { "name": "LOC132344734", "type": "recommended", "evidence": [ { "id": "A0AAA9STD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" } ] } ], "protein_names": [ { "name": "NTF2 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132344734", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5", "locus": {} } ], "crossref": [ { "id": "A0AAA9STD5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10662:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10662:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLSILEQTDKVNPLQRRAPSWGVYQRQYIYWSEQVISQQQQDRDSEESDACMDSQARYASCELPSHHQRSSFQKQDQMHIYMETKQKPPEKRMGRNRQDETLGSWFKIIIPFGIKYDEKWLLNFIQKQSSVPFTAFEFHYEKMQAQFFVENADIACALKNVNGKIFNEVNEKIFILVEPCESPQSVQKALTSEKSLYPSSWLPGDLMTCDIGMTQNCRNGMAASIHIHPGIRPLFSSLDLSNNKPYLLNGLSTIMGNASNTQNLNISNTEVKAEGQMDKGQQLEPEGMCADKNAVCTNFPDKSTNIRLLSLDGQETLSGYKCAIEAPKFLSMWKFFESDQVNSQILQFLQQYYLIHDYGNRQGLLDFYHEEACFFLTIPFHPKDSGLSSVHLYFKDNRNTEKLKDPKLRVQMLKHTKHDIVRALCALPKTQHDFSSFEVDMCFHTETMFCFSVSGVFKEVEGISQGCVCAFTRTFTTTPTSSSSLCIVNEELFVREASPSEAQRLHSPSQCLHCRPRSCSASPLSSRKWCGLSPPSVESPPIVSEVTAAFAWSWEGAGRSGRVSNGNLNVNCFPCLFQLFLP", "length": 583, "header": "tr|A0AAA9STD5-1|A0AAA9STD5_BOVIN Isoform 1 of NTF2 domain-containing protein OS=Bos taurus OX=9913 GN=LOC132344734 PE=3 SV=1 CANONICAL=A0AAA9STD5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5/entry#A0AAA9STD5-1", "sequence": { "sequence": "MLLSILEQTDKVNPLQRRAPSWGVYQRQYIYWSEQVISQQQQDRDSEESDACMDSQARYASCELPSHHQRSSFQKQDQMHIYMETKQKPPEKRMGRNRQDETLGSWFKIIIPFGIKYDEKWLLNFIQKQSSVPFTAFEFHYEKMQAQFFVENADIACALKNVNGKIFNEVNEKIFILVEPCESPQSVQKALTSEKSLYPSSWLPGDLMTCDIGMTQNCRNGMAASIHIHPGIRPLFSSLDLSNNKPYLLNGLSTIMGNASNTQNLNISNTEVKAEGQMDKGQQLEPEGMCADKNAVCTNFPDKSTNIRLLSLDGQETLSGYKCAIEAPKFLSMWKFFESDQVNSQILQFLQQYYLIHDYGNRQGLLDFYHEEACFFLTIPFHPKDSGLSSVHLYFKDNRNTEKLKDPKLRVQMLKHTKHDIVRALCALPKTQHDFSSFEVDMCFHTETMFCFSVSGVFKEVEGISQGCVCAFTRTFTTTPTSSSSLCIVNEELFVREASPSEAQRLHSPSQCLHCRPRSCSASPLSSRKWCGLSPPSVESPPIVSEVTAAFAWSWEGAGRSGRVSNGNLNVNCFPCLFQLFLP", "length": 583, "header": "tr|A0AAA9STD5-1|A0AAA9STD5_BOVIN Isoform 1 of NTF2 domain-containing protein OS=Bos taurus OX=9913 GN=LOC132344734 PE=3 SV=1 CANONICAL=A0AAA9STD5-1" }, "locus": { "chromosome": "NKLS02000262.1", "start_pos": 9043, "end_pos": 3123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120118.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120118.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089684.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089684.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 266, "end_pos": 268, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STD5" }, { "id": "PS50177", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50177" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTF2", "eco_id": "ECO_0000259", "start_pos": 345, "end_pos": 495, "start_aa": "Gln", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 258, "end_pos": 260 }, { "start_pos": 266, "end_pos": 268 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STE2-1", "uniprot_ac": "A0AAA9STE2", "uniprot_id": "A0AAA9STE2_BOVIN", "mass": { "chemical_mass": 8537.0, "monoisotopic_mass": 8537.0 }, "refseq": {}, "gene_names": [ { "name": "MYOCOS", "type": "recommended", "evidence": [ { "id": "A0AAA9STE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2" } ] } ], "protein_names": [ { "name": "Myocilin opposite strand", "type": "recommended", "evidence": [ { "id": "A0AAA9STE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYOCOS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2", "locus": {} } ], "crossref": [ { "id": "A0AAA9STE2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9STE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGKGSTGYSINLPYRDLASEVMRRRITMTRREERFTKQSDDAGEIPSDVESRQPPECSPKVPPAPPPSPAEDFLST", "length": 77, "header": "tr|A0AAA9STE2-1|A0AAA9STE2_BOVIN Isoform 1 of Myocilin opposite strand OS=Bos taurus OX=9913 GN=MYOCOS PE=4 SV=1 CANONICAL=A0AAA9STE2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE2/entry#A0AAA9STE2-1", "sequence": { "sequence": "MAGKGSTGYSINLPYRDLASEVMRRRITMTRREERFTKQSDDAGEIPSDVESRQPPECSPKVPPAPPPSPAEDFLST", "length": 77, "header": "tr|A0AAA9STE2-1|A0AAA9STE2_BOVIN Isoform 1 of Myocilin opposite strand OS=Bos taurus OX=9913 GN=MYOCOS PE=4 SV=1 CANONICAL=A0AAA9STE2-1" }, "locus": { "chromosome": "16", "start_pos": 39089995, "end_pos": 39086791, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098314.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098314.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087241.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087241.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STE7-1", "uniprot_ac": "A0AAA9STE7", "uniprot_id": "A0AAA9STE7_BOVIN", "mass": { "chemical_mass": 35465.0, "monoisotopic_mass": 35465.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7", "locus": {} } ], "crossref": [ { "id": "A0AAA9STE7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005749", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005749", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6J6", "url": "https://www.uniprot.org/uniprotkb/G3X6J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6J6-1", "url": "https://www.uniprot.org/uniprotkb/G3X6J6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GGVGQKSCEAHRETQGLAGAQVTQAENEASYSSSSSLIPHPMEDVSISGTPSSSQCPQSASFSSTVTTGTSLSRSTEGSKEMEQSSTLQSLPDLENLHIDLLDEKVELLINFLLQKYQMREPVTKADMIGNVVKEYKDDFLEILRSASERMELVFGLDVKEVDPINHSYTLANKLDLTYNGMLSDQQGMPKTGLLIIILGVIFMKGNCATEEEVWKVLNMMDIYSGRKHFIFGEPRRLITSDLVMEKYLEYQQVPTSDPPRYEFLWGPRAYAEVSKMKLLEFLAKIHGTNPKSFPSQYEEALRDEEERAGVGLGGKSR", "length": 318, "header": "tr|A0AAA9STE7-1|A0AAA9STE7_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9STE7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7/entry#A0AAA9STE7-1", "sequence": { "sequence": "GGVGQKSCEAHRETQGLAGAQVTQAENEASYSSSSSLIPHPMEDVSISGTPSSSQCPQSASFSSTVTTGTSLSRSTEGSKEMEQSSTLQSLPDLENLHIDLLDEKVELLINFLLQKYQMREPVTKADMIGNVVKEYKDDFLEILRSASERMELVFGLDVKEVDPINHSYTLANKLDLTYNGMLSDQQGMPKTGLLIIILGVIFMKGNCATEEEVWKVLNMMDIYSGRKHFIFGEPRRLITSDLVMEKYLEYQQVPTSDPPRYEFLWGPRAYAEVSKMKLLEFLAKIHGTNPKSFPSQYEEALRDEEERAGVGLGGKSR", "length": 318, "header": "tr|A0AAA9STE7-1|A0AAA9STE7_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9STE7-1" }, "locus": { "chromosome": "X", "start_pos": 106520284, "end_pos": 106518927, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088627.1" } ] } }, { "isoform_ac": "G3X6J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7/entry#G3X6J6-1", "sequence": { "sequence": "VPINAHRETQGLAGAQVTQAENEASYSSSSSLIPHPMEDVSISGTPSSSQCPQSASFSSTVTTGTSLSRSTEGSKEMEQSNLLDEKVELLINFLLQKYQMREPVTKADMIGNVVKEYKDDFLEILRSASERMELVFGLDVKEVDPINHSYTLANKLDLTYNGMLSDQQGMPKTGLLIIILGVIFMKGNCATEEEVWKVLNMMDIYSGRKHFIFGEPRRLITSDLVMEKYLEYQQVPTSDPPRYEFLWGPRAYAEVSKMKLLEFLAKIHGTNPKSFPSQYEEALRDEEERARARIEATAGTSAMASASSGFSHPY", "length": 314, "header": "tr|G3X6J6-1|G3X6J6_BOVIN Computationally mapped isoform of MAGE domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=3 CANONICAL=A0AAA9STE7-1" }, "locus": { "chromosome": "X", "start_pos": 106520188, "end_pos": 106518754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007556.4", "url": "https://www.ensembl.org/id/ENSBTAT00000007556.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007556.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007556.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE7" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 102, "end_pos": 301, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 50 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STH6-1", "uniprot_ac": "A0AAA9STH6", "uniprot_id": "A0AAA9STH6_BOVIN", "mass": { "chemical_mass": 11437.0, "monoisotopic_mass": 11437.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6", "locus": {} } ], "crossref": [ { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QEQVKQSPQSLTVQEGEISILNCSYEKGAFDYLLWHWKYPGKGPAFLIAIRSVMNEMEDGSFTVSLNKSAKQLALHIATSQPGDSATYICAASAGCSPATCTQTCS", "length": 106, "header": "tr|A0AAA9STH6-1|A0AAA9STH6_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9STH6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6/entry#A0AAA9STH6-1", "sequence": { "sequence": "QEQVKQSPQSLTVQEGEISILNCSYEKGAFDYLLWHWKYPGKGPAFLIAIRSVMNEMEDGSFTVSLNKSAKQLALHIATSQPGDSATYICAASAGCSPATCTQTCS", "length": 106, "header": "tr|A0AAA9STH6-1|A0AAA9STH6_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9STH6-1" }, "locus": { "chromosome": "10", "start_pos": 23341193, "end_pos": 23340876, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116953.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116953.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087442.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087442.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 106, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STI6-1", "uniprot_ac": "A0AAA9STI6", "uniprot_id": "A0AAA9STI6_BOVIN", "mass": { "chemical_mass": 61641.0, "monoisotopic_mass": 61641.0 }, "refseq": { "ac": "NP_001192792", "name": "transmembrane protein 151B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192792" }, "gene_names": [ { "name": "TMEM151B", "type": "recommended", "evidence": [ { "id": "A0AAA9STI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6" } ] }, { "name": "TMEM151B", "type": "synonym", "evidence": [ { "id": "NP_001192792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192792" } ] } ], "protein_names": [ { "name": "Transmembrane protein 151B", "type": "synonym", "evidence": [ { "id": "A0AAA9STI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 151B", "type": "synonym", "evidence": [ { "id": "NP_001192792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192792" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM151B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6", "locus": { "chromosome": "23", "start_pos": 17809016, "end_pos": 17776462, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064434", "url": "https://www.ensembl.org/id/ENSBTAG00000064434" } ] } } ], "crossref": [ { "id": "A0AAA9STI6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "519699", "url": "https://www.ncbi.nlm.nih.gov/gene/519699", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519699", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519699", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WYASNST", "url": "https://omabrowser.org/oma/group/WYASNST/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31893", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31893", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31893:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31893:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192792", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPPGSAAGESGGGGGGGGGGPGVPEEPTAAAATDEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKALVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASGSAGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLAGLGARCAGGAAGGYAPTCRYGGVGGPGAAGLAPYRRSCEHCQRAVSSSSIFSRSALSICASPRAAPGPGGVGAGCGGSRFSLGRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMGDDEEDDDEEEAGPPPPYHDALYFPVLIVHRQEGCLGHSHRPLHRHGSCVETSL", "length": 567, "header": "tr|A0AAA9STI6-1|A0AAA9STI6_BOVIN Isoform 1 of Transmembrane protein 151B OS=Bos taurus OX=9913 GN=TMEM151B PE=3 SV=1 CANONICAL=A0AAA9STI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6/entry#A0AAA9STI6-1", "sequence": { "sequence": "MSPPGSAAGESGGGGGGGGGGPGVPEEPTAAAATDEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKALVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASGSAGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLAGLGARCAGGAAGGYAPTCRYGGVGGPGAAGLAPYRRSCEHCQRAVSSSSIFSRSALSICASPRAAPGPGGVGAGCGGSRFSLGRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMGDDEEDDDEEEAGPPPPYHDALYFPVLIVHRQEGCLGHSHRPLHRHGSCVETSL", "length": 567, "header": "tr|A0AAA9STI6-1|A0AAA9STI6_BOVIN Isoform 1 of Transmembrane protein 151B OS=Bos taurus OX=9913 GN=TMEM151B PE=3 SV=1 CANONICAL=A0AAA9STI6-1" }, "locus": { "chromosome": "23", "start_pos": 17780812, "end_pos": 17776596, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132661.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132661.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086391.1" } ] } }, { "isoform_ac": "A0AAA9TC00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6/entry#A0AAA9TC00-1", "sequence": { "sequence": "MSPPGSAAGESGGGGGGGGGGPGVPEEPTAAAATDEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQAPGCPGSQVVPATPQRTAQLDGGSDEVPA", "length": 218, "header": "tr|A0AAA9TC00-1|A0AAA9TC00_BOVIN Computationally mapped isoform of Transmembrane protein 151B OS=Bos taurus OX=9913 GN=TMEM151B PE=3 SV=1 CANONICAL=A0AAA9STI6-1" }, "locus": { "chromosome": "23", "start_pos": 17809013, "end_pos": 17776596, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113655.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113655.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095570.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 29, "start_aa": "Thr", "end_pos": 29, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr29", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:519699", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519699", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZL63-1", "protein_name": "Transmembrane protein 151B", "gene_name": "TMEM151B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPPGSAAGESGGGGGGGGGGPGVPEDPTAAAAAADEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKALVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSAGGSAGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLAGMSARCGGGAAGGYAPTCRYGGVGGPGAAGLAAYRRSCEHCQRAVSSSSIFSRSALSICASPRAGPGPGGGPGCGGSRFSLGRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMGDDEDDDDEEEAGPPPPYHDALYFPVLIVHRQEGCLGHSHRPLHRHGSCVETSL", "length": 567 }, "evidence": [ { "id": "A0AAA9STI6", "url": "https://omabrowser.org/oma/group/A0AAA9STI6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A7E2I7-1", "protein_name": "Transmembrane protein 151B", "gene_name": "tmem151ba", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSPAAPVTESSAAEVHREQTDAPREPQRPLKQSLSKSLCRESHWKCLLLSLLMYCCVIAMTWCQVTKVTRLSFDSTFKVKSMIYHDSPCSNGYIYIPVAFLVMLYVVYLVECWQCYSRNELQFKVDLESVTERVQRMQQATPCIWWKAISYHYIRRTRQVTRYRNGDAYTSTQVYHERVNTHVAEAEFDYGNCGVKDIPKHLAGSDGFPVTKLRFTKCFSFANVESENSYLTQRARFFTENEGLDDYMEAREGMHLKNVEFKEYMVAFADPNRLPWYASTCSFWLAAAFTLSWPLRVLTEYRTAYLHYHVEKLFGFDYVSVTPLDHERPFCRHIPRVNTIDSTELEWHIRSNQQLVPSYSEAVLMNLTQQSSCNTFSARGIGAAGGNGFGGYRQNCERCHRSISSSSIFSRSALSICNSSNPRLAFSSSRFSLGRLYGSRRSCLWQSRSSSLNDPGCPTESTRCLANEESPPSPPAYQDALYFPVLIIHRNEGCIAHDHHSLHRNGSCVETSL", "length": 513 }, "evidence": [ { "id": "A0AAA9STI6", "url": "https://omabrowser.org/oma/group/A0AAA9STI6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZQW5-1", "protein_name": "Transmembrane protein 151B", "gene_name": "Tmem151b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPPGSAAGESAGGGGGGGGSGVPEEPMAAADEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVNSVQERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKALVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASSAGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEVLLMDLVELGSRCGGPGGGFVPRCRYGGVGGPGAAGVTPHWRSCEHCQRAVSSSSIFSRSALSICASPRAAQGPGASAGCGGSRFSLSRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMRDNEDDDDEEEAGPPPPYHDALCFPVLIVHRQEGCLGHSHRSLHRHGSCVETSL", "length": 561 }, "evidence": [ { "id": "A0AAA9STI6", "url": "https://omabrowser.org/oma/group/A0AAA9STI6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NC44-1", "protein_name": "Transmembrane protein 151B", "gene_name": "TMEM151B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSPPASAAAASEGGSSTSVPPEEAEGVREEQRPVKQSLSKSLCRESHWKCLLLSLLMYGCMGAMTWCHVTKVTRLTFDSAYKGKSMMYHDSPCSNGYVYIPLAFLVMLYVVYLVECWHCYTRNELQYKVDVESVHERVQRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYSNCGVKDISKDLIDLESYPATRLRFTKCFSFANVESENSYLTQRARFFTENEGLDDYMEAREGMHLKNVDFKEYMVAFSDPDNLPWYVSHYVFWVAALLTLSWPLRVLNEYRTSYVHYHVEKLFGFDYVAVTPAEERSFCRRMPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLVGLSGCTSYSACRYGGYRQNCERCHRTISSSSIFSRSALSICNGSPRIPFSSSRFSLGRLYGSRRSCLWQSRSGSLNEQSCPTEQTRLSSQVTVEEEDPPPYQDALYFPILIVHRNEGCLNHDHRHLHRNGSCVETSL", "length": 508 }, "evidence": [ { "id": "A0AAA9STI6", "url": "https://omabrowser.org/oma/group/A0AAA9STI6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q68FE7-1", "protein_name": "Transmembrane protein 151B", "gene_name": "Tmem151b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPPGSAAGESAGGGGGGGGSGVPEEPMASADEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVQERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKTLVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASSVGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEVLLMDLVELGSRCGGPGGSYVPRCRYGGVGGPGAAGVTPHWRSCEHCQRAVSSSSIFSRSALSICASPRAAQGPGASAGCGGSRFSLSRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMRDNEEDEDEEEAGPPPPYQDALCFPVLIVHRQEGCLGHSHRSLHRHGSCVETSL", "length": 561 }, "evidence": [ { "id": "A0AAA9STI6", "url": "https://omabrowser.org/oma/group/A0AAA9STI6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IW70-1", "protein_name": "Transmembrane protein 151B", "gene_name": "TMEM151B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPPGSAAGESAAGGGGGGGGPGVSEELTAAAAAAAADEGPAREEQRPIQPSFTKSLCRESHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFLLMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKTLVGLEGAPATRLRFTKCFSFASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSSAFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASSAGGGLSPSDELLPPLTHRLPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLAGLGTRCGGAGGGYAPSCRYGGVGGPGAAGVAPYRRSCEHCQRAVSSSSIFSRSALSICASPRAGPGPGGGAGCGGSRFSLGRLYGSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMGDDEDDDEEEAGPPPPYHDALYFPVLIVHRQEGCLGHSHRPLHRHGSCVETSL", "length": 566 }, "evidence": [ { "id": "A0AAA9STI6", "url": "https://omabrowser.org/oma/group/A0AAA9STI6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 29 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STI8-1", "uniprot_ac": "A0AAA9STI8", "uniprot_id": "A0AAA9STI8_BOVIN", "mass": { "chemical_mass": 50541.0, "monoisotopic_mass": 50541.0 }, "refseq": { "ac": "XP_024852323", "name": "F-box only protein 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852323" }, "gene_names": [ { "name": "FBXO5", "type": "recommended", "evidence": [ { "id": "A0AAA9STI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ] }, { "name": "FBXO5", "type": "synonym", "evidence": [ { "id": "XP_024852323", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852323" } ] } ], "protein_names": [ { "name": "F-box only protein 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024852323", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852323" } ] }, { "name": "F-box protein 5", "type": "synonym", "evidence": [ { "id": "A0AAA9STI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8", "locus": { "chromosome": "9", "start_pos": 89877735, "end_pos": 89889302, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021193", "url": "https://www.ensembl.org/id/ENSBTAG00000021193" } ] } } ], "crossref": [ { "id": "A0AAA9STI8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021193", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021193", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20364", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20364", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515080", "url": "https://www.ncbi.nlm.nih.gov/gene/515080", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VVLSCMQ", "url": "https://omabrowser.org/oma/group/VVLSCMQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5V7", "url": "https://www.orthodb.org/?gene=A0A3Q1M5V7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15493:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15493:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-174113", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174113", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-176417", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176417", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68881", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68881", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024852323", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852323", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5V7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5V7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5V7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRPCSCSLRPLSGSCRCSYGTLTAAGRPCPSDGCKEESSTLSVKMKCDFNYNHVHSGIKPVKPDDSRRKGSYTTAYLEGSYKDCIKDYDRVSDVGSPVVSPRIVELEPESKPLHNKENQHIQQTLDSSNNIQELETSGCYEDSGYSSFSQRSGLSEHEDSSLALVESFNDSPQCCLLQTQSPDQYPNKNLLPALHFEKVVCSTLKKNCKRNPKIDWEKLKEFISSGNFRLQNIIGRKMGLECVDILSELFRRGLKHLLANILTQLSEMDLINVSKVSTTWKKILEDDKVALQLYNKAIQRITEKNIKFSPHASTREYVLFRTPLASVQKSATQTLPKKDARTKLPDPGDQKHSTYSRHSEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKRESCGFDYCTKCLCTYHTTEDCSNGKPLKASYKMGPVPGTKKSKKNLRRL", "length": 448, "header": "tr|A0AAA9STI8-1|A0AAA9STI8_BOVIN Isoform 1 of F-box protein 5 OS=Bos taurus OX=9913 GN=FBXO5 PE=4 SV=1 CANONICAL=A0AAA9STI8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8/entry#A0A3Q1M5V7-1", "sequence": { "sequence": "MATHSSILAWRIPWTEESGCKEESSTLSVKMKCDFNYNHVHSGIKPVKPDDSRRKGSYTTAYLEGSYKDCIKDYDRVSDVGSPVVSPRIVELEPESKPLHNKENQHIQQTLDSSNNIQELETSGCYEDSGYSSFSQRSGLSEHEDSSLALVESFNDSPQCCLLQTQSPDQYPNKNLLPALHFEKVVCSTLKKNCKRNPKIDWEKLKEFISSGNFRLQNIIGRKMGLECVDILSELFRRGLKHLLANILTQLSEMDLINVSKVSTTWKKILEDDKVALQLYNKAIQRITEKNIKFSPHASTREYVLFRTPLASVQKSATQTLPKKDARTKLPDPGDQKHSTYSRHSEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKRESCGFDYCTKCLCTYHTTEDCSNGKPLKASYKMGPVPGTKKSKKNLRRL", "length": 432, "header": "tr|A0A3Q1M5V7-1|A0A3Q1M5V7_BOVIN Computationally mapped isoform of F-box protein 5 OS=Bos taurus OX=9913 GN=FBXO5 PE=4 SV=2 CANONICAL=A0AAA9STI8-1" }, "locus": { "chromosome": "9", "start_pos": 89885157, "end_pos": 89878739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083057.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083057.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063665.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063665.2" } ] } }, { "isoform_ac": "A0AAA9STI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8/entry#A0AAA9STI8-1", "sequence": { "sequence": "MSRRPCSCSLRPLSGSCRCSYGTLTAAGRPCPSDGCKEESSTLSVKMKCDFNYNHVHSGIKPVKPDDSRRKGSYTTAYLEGSYKDCIKDYDRVSDVGSPVVSPRIVELEPESKPLHNKENQHIQQTLDSSNNIQELETSGCYEDSGYSSFSQRSGLSEHEDSSLALVESFNDSPQCCLLQTQSPDQYPNKNLLPALHFEKVVCSTLKKNCKRNPKIDWEKLKEFISSGNFRLQNIIGRKMGLECVDILSELFRRGLKHLLANILTQLSEMDLINVSKVSTTWKKILEDDKVALQLYNKAIQRITEKNIKFSPHASTREYVLFRTPLASVQKSATQTLPKKDARTKLPDPGDQKHSTYSRHSEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKRESCGFDYCTKCLCTYHTTEDCSNGKPLKASYKMGPVPGTKKSKKNLRRL", "length": 448, "header": "tr|A0AAA9STI8-1|A0AAA9STI8_BOVIN Isoform 1 of F-box protein 5 OS=Bos taurus OX=9913 GN=FBXO5 PE=4 SV=1 CANONICAL=A0AAA9STI8-1" }, "locus": { "chromosome": "9", "start_pos": 89889212, "end_pos": 89878739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098596.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098596.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087452.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-174113", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174113", "resource": "Reactome", "description": "SCF-beta-TrCP mediated degradation of Emi1" }, { "id": "R-BTA-176408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176408", "resource": "Reactome", "description": "Regulation of APC/C activators between G1/S and early anaphase" }, { "id": "R-BTA-176417", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176417", "resource": "Reactome", "description": "Phosphorylation of Emi1" }, { "id": "R-BTA-68881", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68881", "resource": "Reactome", "description": "Mitotic Metaphase/Anaphase Transition" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7TSG3-1", "protein_name": "F-box only protein 5", "gene_name": "Fbxo5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRRTCSDLRRPSSCPCRLGARTTVDGCKEESPVLSVTMKCFNCNPDLSELEVVKPEDSGIEASYSPVCLEPSCNDCVRNHERLSFIDSPIVGHDNKENQRVQNTLDSSNETEELEASRLYEDSGYSSFTQSDRDDGILILENFRNSPQARLLPSQSPDQHPNKTLLPVLHFERVVCSTLKKNGKRNPKVDREMLKEVIASGNFRLQNIIGKKMGLEHLDILAELSRRGFVHLLANILTKLSGMDLVNLSKVSRIWKKILENNKGAFQLYSKTMQRVIESSKLSLHATTRGYVVGRAALTCVQKSSTWAPPKKDVQIKSSSQRGQRVSTYSRHNEFVEVAKTLKNNESLKACVRCNFPAKYDHYLERAVCKRESCQFEYCTKCLCAYHNNKDCLNGKILKASCKVGPLPGTKKSKKNLQRL", "length": 421 }, "evidence": [ { "id": "A0AAA9STI8", "url": "https://omabrowser.org/oma/group/A0AAA9STI8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UKT4-1", "protein_name": "F-box only protein 5", "gene_name": "FBXO5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL", "length": 447 }, "evidence": [ { "id": "A0AAA9STI8", "url": "https://omabrowser.org/oma/group/A0AAA9STI8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "meiotic spindle", "id": "GO:0072687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072687", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "ubiquitin ligase inhibitor activity", "id": "GO:1990948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990948", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "anaphase-promoting complex binding", "id": "GO:0010997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010997", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "positive regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010971", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "positive regulation of mesenchymal stem cell migration", "id": "GO:1905322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905322", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "negative regulation of cellular senescence", "id": "GO:2000773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000773", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "positive regulation of osteoblast differentiation", "id": "GO:0045669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "positive regulation of biomineral tissue development", "id": "GO:0070169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070169", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "negative regulation of DNA endoreduplication", "id": "GO:0032876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032876", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "negative regulation of mitotic metaphase/anaphase transition", "id": "GO:0045841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045841", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "negative regulation of meiotic nuclear division", "id": "GO:0045835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045835", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" }, { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI8" }, { "id": "PS51872", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51872" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZBR-type", "eco_id": "ECO_0000259", "start_pos": 375, "end_pos": 423, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 274, "end_pos": 276 }, { "start_pos": 373, "end_pos": 375 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STL3-1", "uniprot_ac": "A0AAA9STL3", "uniprot_id": "A0AAA9STL3_BOVIN", "mass": { "chemical_mass": 37213.0, "monoisotopic_mass": 37213.0 }, "refseq": {}, "gene_names": [ { "name": "CEBPA", "type": "recommended", "evidence": [ { "id": "A0AAA9STL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ] } ], "protein_names": [ { "name": "CCAAT enhancer binding protein alpha", "type": "synonym", "evidence": [ { "id": "A0AAA9STL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEBPA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3", "locus": { "chromosome": "18", "start_pos": 43722392, "end_pos": 43731408, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065802", "url": "https://www.ensembl.org/id/ENSBTAG00000065802" } ] } } ], "crossref": [ { "id": "cd14711", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14711", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23334:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23334:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPSQPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAAPAGGGNDFDYPGAPVGPGGAVMPGGTHGPPPGYGCAAAGYLDSRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHSHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGGALKGLAATHPDLRAGGGGGGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA", "length": 353, "header": "tr|A0AAA9STL3-1|A0AAA9STL3_BOVIN Isoform 1 of CCAAT enhancer binding protein alpha OS=Bos taurus OX=9913 GN=CEBPA PE=3 SV=1 CANONICAL=A0AAA9STL3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3/entry#A0AAA9STL3-1", "sequence": { "sequence": "MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPSQPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAAPAGGGNDFDYPGAPVGPGGAVMPGGTHGPPPGYGCAAAGYLDSRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHSHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGGALKGLAATHPDLRAGGGGGGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA", "length": 353, "header": "tr|A0AAA9STL3-1|A0AAA9STL3_BOVIN Isoform 1 of CCAAT enhancer binding protein alpha OS=Bos taurus OX=9913 GN=CEBPA PE=3 SV=1 CANONICAL=A0AAA9STL3-1" }, "locus": { "chromosome": "18", "start_pos": 43727089, "end_pos": 43726859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116686.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116686.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086425.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086425.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 222, "start_aa": "Thr", "end_pos": 222, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr222", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 226, "start_aa": "Thr", "end_pos": 226, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr226", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "granulocyte differentiation", "id": "GO:0030851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030851", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "positive regulation of macrophage activation", "id": "GO:0043032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043032", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "energy homeostasis", "id": "GO:0097009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097009", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "negative regulation of cell cycle", "id": "GO:0045786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "interleukin-6-mediated signaling pathway", "id": "GO:0070102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "STAT family protein binding", "id": "GO:0097677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL3" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 277, "end_pos": 340, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 222, 226 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STL4-1", "uniprot_ac": "A0AAA9STL4", "uniprot_id": "A0AAA9STL4_BOVIN", "mass": { "chemical_mass": 21959.0, "monoisotopic_mass": 21959.0 }, "refseq": { "ac": "XP_005228110", "name": "rho-related GTP-binding protein RhoG", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228110" }, "gene_names": [ { "name": "RHOG2", "type": "recommended", "evidence": [ { "id": "A0AAA9STL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4" } ] }, { "name": "RHOG2", "type": "synonym", "evidence": [ { "id": "XP_005228110", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228110" } ] } ], "protein_names": [ { "name": "Rho-related GTP-binding protein RhoG", "type": "recommended", "evidence": [ { "id": "A0AAA9STL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4/entry#names_and_taxonomy" } ] }, { "name": "rho-related GTP-binding protein RhoG", "type": "synonym", "evidence": [ { "id": "XP_005228110", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228110" } ] } ], "function": [ { "annotation": "Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4#function" }, { "database": "UniProtKB", "id": "ARBA00059483", "url": "https://www.uniprot.org/uniprotkb/ARBA00059483#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHOG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4", "locus": {} } ], "crossref": [ { "id": "A0AAA9STL4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "531038", "url": "https://www.ncbi.nlm.nih.gov/gene/531038", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531038", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531038", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24072", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24072", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228110", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228110", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSKGRMQTIKCVVVGDGAVGKTCLLISYTTNAFPEEYIPTVFDNYSAQTSVDGQIVILNLWDTAGQEEYDRLRTLSYPQTNIFVICFSIGNPSSYANVRHKWYPEVSHHCPNVPVLLVGTKRDLRSDLETVKKLKEQSLVPTSPQQGTSLAKQVGAVKYLECSALMHDGVREVFLEAIRAVLYPATKKNTKKCVLL", "length": 197, "header": "tr|A0AAA9STL4-1|A0AAA9STL4_BOVIN Isoform 1 of Rho-related GTP-binding protein RhoG OS=Bos taurus OX=9913 GN=RHOG2 PE=4 SV=1 CANONICAL=A0AAA9STL4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4/entry#A0AAA9STL4-1", "sequence": { "sequence": "MDSKGRMQTIKCVVVGDGAVGKTCLLISYTTNAFPEEYIPTVFDNYSAQTSVDGQIVILNLWDTAGQEEYDRLRTLSYPQTNIFVICFSIGNPSSYANVRHKWYPEVSHHCPNVPVLLVGTKRDLRSDLETVKKLKEQSLVPTSPQQGTSLAKQVGAVKYLECSALMHDGVREVFLEAIRAVLYPATKKNTKKCVLL", "length": 197, "header": "tr|A0AAA9STL4-1|A0AAA9STL4_BOVIN Isoform 1 of Rho-related GTP-binding protein RhoG OS=Bos taurus OX=9913 GN=RHOG2 PE=4 SV=1 CANONICAL=A0AAA9STL4-1" }, "locus": { "chromosome": "X", "start_pos": 79296929, "end_pos": 79296164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122263.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122263.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088691.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531038", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531038", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STN6-1", "uniprot_ac": "A0AAA9STN6", "uniprot_id": "A0AAA9STN6_BOVIN", "mass": { "chemical_mass": 41919.0, "monoisotopic_mass": 41919.0 }, "refseq": {}, "gene_names": [ { "name": "EEIG1", "type": "recommended", "evidence": [ { "id": "A0AAA9STN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" } ] } ], "protein_names": [ { "name": "Estrogen-induced osteoclastosis regulator 1", "type": "synonym", "evidence": [ { "id": "A0AAA9STN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EEIG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6", "locus": { "chromosome": "11", "start_pos": 98603817, "end_pos": 98643064, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023851", "url": "https://www.ensembl.org/id/ENSBTAG00000023851" } ] } } ], "crossref": [ { "id": "A0AAA9STN6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023851", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023851", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21456", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21456", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21456:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21456:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10358", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10358", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIT7", "url": "https://www.uniprot.org/uniprotkb/F1MIT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIT7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCIFRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSRGGSSNSLTGSRPPKARPTILSSGVPEEPDQSLSSPEEVFHSGHSRNSSYASQQSKISAGYSTEQSRSSSLSDLTHRRNTSTSSSASGGLSMAVEGPEGSEREHRPPEKPPRPPRPPHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTEGSNTEDSNLRLFVSRDGTTTLSGIQLANRVSSGVYEPVVIESH", "length": 384, "header": "tr|A0AAA9STN6-1|A0AAA9STN6_BOVIN Isoform 1 of Estrogen-induced osteoclastosis regulator 1 OS=Bos taurus OX=9913 GN=EEIG1 PE=3 SV=1 CANONICAL=A0AAA9STN6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6/entry#A0AAA9STN6-1", "sequence": { "sequence": "MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCIFRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSRGGSSNSLTGSRPPKARPTILSSGVPEEPDQSLSSPEEVFHSGHSRNSSYASQQSKISAGYSTEQSRSSSLSDLTHRRNTSTSSSASGGLSMAVEGPEGSEREHRPPEKPPRPPRPPHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTEGSNTEDSNLRLFVSRDGTTTLSGIQLANRVSSGVYEPVVIESH", "length": 384, "header": "tr|A0AAA9STN6-1|A0AAA9STN6_BOVIN Isoform 1 of Estrogen-induced osteoclastosis regulator 1 OS=Bos taurus OX=9913 GN=EEIG1 PE=3 SV=1 CANONICAL=A0AAA9STN6-1" }, "locus": { "chromosome": "11", "start_pos": 98642865, "end_pos": 98609981, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090770.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090770.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088712.1" } ] } }, { "isoform_ac": "F1MIT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6/entry#F1MIT7-1", "sequence": { "sequence": "MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCIFRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSRGGSSNSLTGSRPPKARPTILSSGVPEEPDQSLSSPEEVFHSGHSRNSSYASQQSKISGYSTEQSRSSSLSDLTHRRNTSTSSSASGGLSMAVEGPEGSEREHRPPEKPPRPPRPPHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTEGSNTEDSNLRLFVSRDGTTTLSGIQLANRTEPTRAKPV", "length": 378, "header": "tr|F1MIT7-1|A0AAA9STN6_BOVIN Computationally mapped isoform of Estrogen-induced osteoclastosis regulator 1 OS=Bos taurus OX=9913 GN=EEIG1 PE=3 SV=2 CANONICAL=A0AAA9STN6-1" }, "locus": { "chromosome": "11", "start_pos": 98642865, "end_pos": 98603962, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032754.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032754.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032683.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032683.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of osteoclast differentiation", "id": "GO:0045672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STN6" }, { "id": "PS51840", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51840" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2 NT-type", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 145, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 228, "end_pos": 230 }, { "start_pos": 260, "end_pos": 262 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STR5-1", "uniprot_ac": "A0AAA9STR5", "uniprot_id": "A0AAA9STR5_BOVIN", "mass": { "chemical_mass": 34838.0, "monoisotopic_mass": 34838.0 }, "refseq": { "ac": "XP_024831680", "name": "complement C1q tumor necrosis factor-related protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831680" }, "gene_names": [ { "name": "C1QTNF4", "type": "recommended", "evidence": [ { "id": "A0AAA9STR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ] }, { "name": "C1QTNF4", "type": "synonym", "evidence": [ { "id": "XP_024831680", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831680" } ] } ], "protein_names": [ { "name": "Complement C1q tumor necrosis factor-related protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9STR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5/entry#names_and_taxonomy" } ] }, { "name": "C1q/TNF-related protein 4", "type": "synonym", "evidence": [ { "id": "A0AAA9STR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5/entry#names_and_taxonomy" } ] }, { "name": "complement C1q tumor necrosis factor-related protein 4", "type": "synonym", "evidence": [ { "id": "XP_024831680", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831680" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1QTNF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5", "locus": { "chromosome": "15", "start_pos": 77387825, "end_pos": 77392622, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000053126", "url": "https://www.ensembl.org/id/ENSBTAG00000053126" } ] } } ], "crossref": [ { "id": "A0AAA9STR5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "617462", "url": "https://www.ncbi.nlm.nih.gov/gene/617462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617462", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617462", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR22923", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22923", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22923:SF118", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22923:SF118", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024831680", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831680", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLLLLGLLSPAAYGAPGPAPGSAELRSAFSAARTTPLEGTSEMAVTFDKVYVNVGGDFDPATGQFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQALAFDEQRRPGTRRAASQSAMLQLDYGDSVWLRLHGAPRYALGAPGATFSGYLVYADADAPARGGPPAPAEPRSAFSAARTRSLVGSDAGPGPRHRPLAFDTELVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLALRRGDAVWLLSHDRDGYGAYSNHGKYITFSGFLVYPDLPPAGPPGLGPPEL", "length": 325, "header": "tr|A0AAA9STR5-1|A0AAA9STR5_BOVIN Isoform 1 of Complement C1q tumor necrosis factor-related protein 4 OS=Bos taurus OX=9913 GN=C1QTNF4 PE=4 SV=1 CANONICAL=A0AAA9STR5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5/entry#A0AAA9STR5-1", "sequence": { "sequence": "MLLLLLGLLSPAAYGAPGPAPGSAELRSAFSAARTTPLEGTSEMAVTFDKVYVNVGGDFDPATGQFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQALAFDEQRRPGTRRAASQSAMLQLDYGDSVWLRLHGAPRYALGAPGATFSGYLVYADADAPARGGPPAPAEPRSAFSAARTRSLVGSDAGPGPRHRPLAFDTELVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLALRRGDAVWLLSHDRDGYGAYSNHGKYITFSGFLVYPDLPPAGPPGLGPPEL", "length": 325, "header": "tr|A0AAA9STR5-1|A0AAA9STR5_BOVIN Isoform 1 of Complement C1q tumor necrosis factor-related protein 4 OS=Bos taurus OX=9913 GN=C1QTNF4 PE=4 SV=1 CANONICAL=A0AAA9STR5-1" }, "locus": { "chromosome": "15", "start_pos": 77388822, "end_pos": 77387848, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067550.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067550.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088741.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088741.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617462", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617462", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of interleukin-6-mediated signaling pathway", "id": "GO:0070105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070105", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STR5" }, { "id": "PS50871", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50871" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 160, "start_aa": "Ser", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STT7-1", "uniprot_ac": "A0AAA9STT7", "uniprot_id": "A0AAA9STT7_BOVIN", "mass": { "chemical_mass": 34382.0, "monoisotopic_mass": 34382.0 }, "refseq": { "ac": "NP_001377666", "name": "olfactory receptor family 5 subfamily T member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377666" }, "gene_names": [ { "name": "OR5T2", "type": "recommended", "evidence": [ { "id": "A0AAA9STT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7" } ] }, { "name": "OR5T2", "type": "synonym", "evidence": [ { "id": "NP_001377666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377666" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9STT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 5 subfamily T member 2", "type": "synonym", "evidence": [ { "id": "NP_001377666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377666" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377666" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5T2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7", "locus": { "chromosome": "15", "start_pos": 79455708, "end_pos": 79456628, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057857", "url": "https://www.ensembl.org/id/ENSBTAG00000057857" } ] } } ], "crossref": [ { "id": "A0AAA9STT7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STT7", "database": "AlphaFoldDB", "categories": [] }, { "id": "104969845", "url": "https://www.ncbi.nlm.nih.gov/gene/104969845", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104969845", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104969845", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377666", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNTAEVTIFVLKGLTDNPEIQFILFFLFLAIYLFTLIGNLGLVILVIGDCRLHNPMYYFLSVLSSVDACYSSVITPKMLVDFMSKNKTILLPECAAQMFLSTTFGTTECFLLAAMAYDRYVAIYNPLLYSASMAPRVYVPLIIASYVGGIVHATVHTVATFSLSFCASNEIRHVFCDIPPLLAISCSDTHTNQLLLFYLVCSIEIVTVLIVLISYGFILLAILRMHSTEGRRKVFSTCGSHLTGVSVFHGTILFMYVRPSSSYALDHDMIVSLFYSVVIPMLNPIIYSLRNKDVKEAMNRRFWKI", "length": 306, "header": "tr|A0AAA9STT7-1|A0AAA9STT7_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5T2 PE=3 SV=1 CANONICAL=A0AAA9STT7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7/entry#A0AAA9STT7-1", "sequence": { "sequence": "MKNTAEVTIFVLKGLTDNPEIQFILFFLFLAIYLFTLIGNLGLVILVIGDCRLHNPMYYFLSVLSSVDACYSSVITPKMLVDFMSKNKTILLPECAAQMFLSTTFGTTECFLLAAMAYDRYVAIYNPLLYSASMAPRVYVPLIIASYVGGIVHATVHTVATFSLSFCASNEIRHVFCDIPPLLAISCSDTHTNQLLLFYLVCSIEIVTVLIVLISYGFILLAILRMHSTEGRRKVFSTCGSHLTGVSVFHGTILFMYVRPSSSYALDHDMIVSLFYSVVIPMLNPIIYSLRNKDVKEAMNRRFWKI", "length": 306, "header": "tr|A0AAA9STT7-1|A0AAA9STT7_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5T2 PE=3 SV=1 CANONICAL=A0AAA9STT7-1" }, "locus": { "chromosome": "15", "start_pos": 79456628, "end_pos": 79455711, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089170.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089170.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086512.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104969845", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104969845", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT7" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STX6-1", "uniprot_ac": "A0AAA9STX6", "uniprot_id": "A0AAA9STX6_BOVIN", "mass": { "chemical_mass": 11425.0, "monoisotopic_mass": 11425.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9STX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6", "locus": {} } ], "crossref": [ { "id": "A0AAA9STX6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STX6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19343:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19343:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9STX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QEQVKQSPQSLTVQEGEISILNCSYEKGTFDYLLWHWQYPGKGPAFLIAIRSVMNEMEDGSFTVSLNKSAKQLSLHIATSQPGASATYICAASAGCSPGTCTQTCS", "length": 106, "header": "tr|A0AAA9STX6-1|A0AAA9STX6_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9STX6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6/entry#A0AAA9STX6-1", "sequence": { "sequence": "QEQVKQSPQSLTVQEGEISILNCSYEKGTFDYLLWHWQYPGKGPAFLIAIRSVMNEMEDGSFTVSLNKSAKQLSLHIATSQPGASATYICAASAGCSPGTCTQTCS", "length": 106, "header": "tr|A0AAA9STX6-1|A0AAA9STX6_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9STX6-1" }, "locus": { "chromosome": "10", "start_pos": 23101074, "end_pos": 23100757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127559.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127559.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089875.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 106, "start_aa": "Glu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STY2-1", "uniprot_ac": "A0AAA9STY2", "uniprot_id": "A0AAA9STY2_BOVIN", "mass": { "chemical_mass": 24873.0, "monoisotopic_mass": 24873.0 }, "refseq": { "ac": "XP_005201407", "name": "zinc finger BED domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201407" }, "gene_names": [ { "name": "ZBED2", "type": "recommended", "evidence": [ { "id": "A0AAA9STY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" } ] }, { "name": "ZBED2", "type": "synonym", "evidence": [ { "id": "XP_005201407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201407" } ] } ], "protein_names": [ { "name": "Zinc finger BED-type containing 2", "type": "synonym", "evidence": [ { "id": "A0AAA9STY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger BED domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_005201407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201407" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBED2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2", "locus": { "chromosome": "1", "start_pos": 56335278, "end_pos": 56344811, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064913", "url": "https://www.ensembl.org/id/ENSBTAG00000064913" } ] } } ], "crossref": [ { "id": "539880", "url": "https://www.ncbi.nlm.nih.gov/gene/539880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539880", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539880", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHHPNQY", "url": "https://omabrowser.org/oma/group/GHHPNQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR35827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35827:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35827:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02892", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02892", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005201407", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201407", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRREEEEEDGNRMKAKGRLEVKEEEEISEAGEPVAPFVGATPTPMPHNKGTRFSEAWEYFHLAPARAGHHPNQYATCRLCGRQVSRGPGVNVGTTALWKHLKSMHKDELEKSGHGQAGQRQDPRPQGSQLPTGIEGDWARLLEQMGALALWASQREKELLRRERAVEWRERAVERRERALEEVERAILEMRRKVRAEKEACQREKDQSGAAHPFHFV", "length": 217, "header": "tr|A0AAA9STY2-1|A0AAA9STY2_BOVIN Isoform 1 of Zinc finger BED-type containing 2 OS=Bos taurus OX=9913 GN=ZBED2 PE=4 SV=1 CANONICAL=A0AAA9STY2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2/entry#A0AAA9STY2-1", "sequence": { "sequence": "MRREEEEEDGNRMKAKGRLEVKEEEEISEAGEPVAPFVGATPTPMPHNKGTRFSEAWEYFHLAPARAGHHPNQYATCRLCGRQVSRGPGVNVGTTALWKHLKSMHKDELEKSGHGQAGQRQDPRPQGSQLPTGIEGDWARLLEQMGALALWASQREKELLRRERAVEWRERAVERRERALEEVERAILEMRRKVRAEKEACQREKDQSGAAHPFHFV", "length": 217, "header": "tr|A0AAA9STY2-1|A0AAA9STY2_BOVIN Isoform 1 of Zinc finger BED-type containing 2 OS=Bos taurus OX=9913 GN=ZBED2 PE=4 SV=1 CANONICAL=A0AAA9STY2-1" }, "locus": { "chromosome": "1", "start_pos": 56341204, "end_pos": 56341041, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098183.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098183.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087462.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087462.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 43, "start_aa": "Thr", "end_pos": 43, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539880", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539880", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SLS2-1", "protein_name": "Zinc finger BED-type containing 2", "gene_name": "ZBED2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRREEEEEEGTRMKAKGHLEVKEEEEVSETGELVGPLAGAVPTPMPHNKGSRFSEAWEYFHLAPARAGHHPNQYATCRLCGRQVSRGPGVNVGTTALWKHLKSMHKEELEKGGHGQAGQRQDPSLQGPQLPMGIEGDWARLLEQVGALALWASQREREILRRERAVEWRERAVERRERALEEVERAILEMKRKIRAEKEACQREKDQPTAAHPFHFV", "length": 217 }, "evidence": [ { "id": "A0AAA9STY2", "url": "https://omabrowser.org/oma/group/A0AAA9STY2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9BTP6-1", "protein_name": "Zinc finger BED domain-containing protein 2", "gene_name": "ZBED2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMRREDEEEEGTMMKAKGDLEMKEEEEISETGELVGPFVSAMPTPMPHNKGTRFSEAWEYFHLAPARAGHHPNQYATCRLCGRQVSRGPGVNVGTTALWKHLKSMHREELEKSGHGQAGQRQDPRPHGPQLPTGIEGNWGRLLEQVGTMALWASQREKEVLRRERAVEWRERAVEKRERALEEVERAILEMKWKVRAEKEACQREKELPAAVHPFHFV", "length": 218 }, "evidence": [ { "id": "A0AAA9STY2", "url": "https://omabrowser.org/oma/group/A0AAA9STY2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of keratinocyte differentiation", "id": "GO:0045618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045618", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY2" }, { "id": "PS50808", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50808" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BED-type", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 112, "start_aa": "Thr", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 43 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STY9-1", "uniprot_ac": "A0AAA9STY9", "uniprot_id": "A0AAA9STY9_BOVIN", "mass": { "chemical_mass": 13639.0, "monoisotopic_mass": 13639.0 }, "refseq": { "ac": "XP_005213307", "name": "calcium channel flower homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213307" }, "gene_names": [ { "name": "CACFD1", "type": "recommended", "evidence": [ { "id": "A0AAA9STY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9" } ] }, { "name": "C11H9orf7", "type": "synonym", "evidence": [ { "id": "XP_005213307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213307" } ] }, { "name": "CACFD1", "type": "synonym", "evidence": [ { "id": "XP_005213307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213307" } ] } ], "protein_names": [ { "name": "Calcium channel flower domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9STY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9/entry#names_and_taxonomy" } ] }, { "name": "calcium channel flower homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005213307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213307" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CACFD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9", "locus": { "chromosome": "11", "start_pos": 104361244, "end_pos": 104352263, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015097", "url": "https://www.ensembl.org/id/ENSBTAG00000015097" } ] } } ], "crossref": [ { "id": "A0AAA9STY9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "512024", "url": "https://www.ncbi.nlm.nih.gov/gene/512024", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13314", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13314", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13314:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13314:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005213307", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213307", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9STY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGAGGAAVAPGSSAQPAQEEGMTWWYRWLCRLSGVLGAVSCAISGLFNCITIHPLNIAAGVWMVMAVVPIVISLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQVDEEKLTDTLEGEL", "length": 130, "header": "tr|A0AAA9STY9-1|A0AAA9STY9_BOVIN Isoform 1 of Calcium channel flower domain containing 1 OS=Bos taurus OX=9913 GN=CACFD1 PE=3 SV=1 CANONICAL=A0AAA9STY9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9/entry#A0AAA9STY9-1", "sequence": { "sequence": "MSGAGGAAVAPGSSAQPAQEEGMTWWYRWLCRLSGVLGAVSCAISGLFNCITIHPLNIAAGVWMVMAVVPIVISLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQVDEEKLTDTLEGEL", "length": 130, "header": "tr|A0AAA9STY9-1|A0AAA9STY9_BOVIN Isoform 1 of Calcium channel flower domain containing 1 OS=Bos taurus OX=9913 GN=CACFD1 PE=3 SV=1 CANONICAL=A0AAA9STY9-1" }, "locus": { "chromosome": "11", "start_pos": 104359758, "end_pos": 104352290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112666.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112666.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088808.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU21-1", "uniprot_ac": "A0AAA9SU21", "uniprot_id": "A0AAA9SU21_BOVIN", "mass": { "chemical_mass": 38271.0, "monoisotopic_mass": 38271.0 }, "refseq": {}, "gene_names": [ { "name": "SBK3", "type": "recommended", "evidence": [ { "id": "A0AAA9SU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21" } ] } ], "protein_names": [ { "name": "SH3 domain binding kinase family member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SBK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21", "locus": { "chromosome": "18", "start_pos": 61982781, "end_pos": 61976824, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055461", "url": "https://www.ensembl.org/id/ENSBTAG00000055461" } ] } } ], "crossref": [ { "id": "A0AAA9SU21", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU21", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24359:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24359:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SU21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELRDPKKQEDGDPEEDTATALQRLVDLTASRVTPVRSLRAHYRLIRRLGSGSYGHVLLARPRQGGRAVALKLLPRASVFRTTFLREFCVGRCVSSHPGLLQTLAGPLETPRHFAFAQEYAPCGDLSGMLQERGLPELLLKRVVAQLAGALDFLHGRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSPTPAPPGPLPSAPPELCVLLPPDTLPLRPALDSWGLGVLLFCAATACFPWDVALAPDPEFEVFAGWMTARPQPPRPPPPWDQFAPPALALFQGLLDLDPETRSPPLVVLDFLGDDWGLNGNKDRAGGLGSMSSEGGEEGGASLEEWSEEEDGDSGGRTGTDAGEP", "length": 357, "header": "tr|A0AAA9SU21-1|A0AAA9SU21_BOVIN Isoform 1 of SH3 domain binding kinase family member 3 OS=Bos taurus OX=9913 GN=SBK3 PE=3 SV=1 CANONICAL=A0AAA9SU21-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21/entry#A0AAA9SU21-1", "sequence": { "sequence": "MELRDPKKQEDGDPEEDTATALQRLVDLTASRVTPVRSLRAHYRLIRRLGSGSYGHVLLARPRQGGRAVALKLLPRASVFRTTFLREFCVGRCVSSHPGLLQTLAGPLETPRHFAFAQEYAPCGDLSGMLQERGLPELLLKRVVAQLAGALDFLHGRGLVHADVKPDNVLVFDPVCSRVALGDLGLTRPEGSPTPAPPGPLPSAPPELCVLLPPDTLPLRPALDSWGLGVLLFCAATACFPWDVALAPDPEFEVFAGWMTARPQPPRPPPPWDQFAPPALALFQGLLDLDPETRSPPLVVLDFLGDDWGLNGNKDRAGGLGSMSSEGGEEGGASLEEWSEEEDGDSGGRTGTDAGEP", "length": 357, "header": "tr|A0AAA9SU21-1|A0AAA9SU21_BOVIN Isoform 1 of SH3 domain binding kinase family member 3 OS=Bos taurus OX=9913 GN=SBK3 PE=3 SV=1 CANONICAL=A0AAA9SU21-1" }, "locus": { "chromosome": "18", "start_pos": 61982778, "end_pos": 61977023, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108583.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108583.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087647.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087647.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 194, "start_aa": "Thr", "end_pos": 194, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr194", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU21" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 309, "start_aa": "Tyr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 194 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU30-1", "uniprot_ac": "A0AAA9SU30", "uniprot_id": "A0AAA9SU30_BOVIN", "mass": { "chemical_mass": 21076.0, "monoisotopic_mass": 21076.0 }, "refseq": { "ac": "XP_015328992", "name": "uncharacterized protein C2orf74 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328992" }, "gene_names": [ { "name": "C11H2orf74", "type": "recommended", "evidence": [ { "id": "A0AAA9SU30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30" } ] }, { "name": "C11H2orf74", "type": "synonym", "evidence": [ { "id": "XP_015328992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328992" } ] } ], "protein_names": [ { "name": "Chromosome 11 C2orf74 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SU30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C2orf74 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015328992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328992" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C11H2orf74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30", "locus": { "chromosome": "11", "start_pos": 59822431, "end_pos": 59810822, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047149", "url": "https://www.ensembl.org/id/ENSBTAG00000047149" } ] } } ], "crossref": [ { "id": "A0AAA9SU30", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU30", "database": "AlphaFoldDB", "categories": [] }, { "id": "100294981", "url": "https://www.ncbi.nlm.nih.gov/gene/100294981", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100294981", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100294981", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR37882", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37882", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15484", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15484", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015328992", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328992", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SU30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRLVNHMNFETTAFTFFIILLICLSCIFLLLVVFLYKCSQSRTDEETEKGPCTENEGEDCPAANTEMNNLDNQEKTLAPARHGILVQRRSKDAMTTPLGNREDVEGEEENKIKEKQKPENARENGQEDDYLQKSLIPLTGSSSVVDNHKRPLKGVTFSREVIVVDLGKDNPMARSYTRLHKERK", "length": 185, "header": "tr|A0AAA9SU30-1|A0AAA9SU30_BOVIN Isoform 1 of Chromosome 11 C2orf74 homolog OS=Bos taurus OX=9913 GN=C11H2orf74 PE=4 SV=2 CANONICAL=A0AAA9SU30-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU30/entry#A0AAA9SU30-1", "sequence": { "sequence": "MSRLVNHMNFETTAFTFFIILLICLSCIFLLLVVFLYKCSQSRTDEETEKGPCTENEGEDCPAANTEMNNLDNQEKTLAPARHGILVQRRSKDAMTTPLGNREDVEGEEENKIKEKQKPENARENGQEDDYLQKSLIPLTGSSSVVDNHKRPLKGVTFSREVIVVDLGKDNPMARSYTRLHKERK", "length": 185, "header": "tr|A0AAA9SU30-1|A0AAA9SU30_BOVIN Isoform 1 of Chromosome 11 C2orf74 homolog OS=Bos taurus OX=9913 GN=C11H2orf74 PE=4 SV=2 CANONICAL=A0AAA9SU30-1" }, "locus": { "chromosome": "11", "start_pos": 59822014, "end_pos": 59820325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121840.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121840.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089928.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089928.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100294981", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100294981", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU46-1", "uniprot_ac": "A0AAA9SU46", "uniprot_id": "A0AAA9SU46_BOVIN", "mass": { "chemical_mass": 35383.0, "monoisotopic_mass": 35383.0 }, "refseq": { "ac": "NP_001377474", "name": "olfactory receptor family 4 subfamily L member 16", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377474" }, "gene_names": [ { "name": "OR4L16", "type": "recommended", "evidence": [ { "id": "A0AAA9SU46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46" } ] }, { "name": "OR4L16", "type": "synonym", "evidence": [ { "id": "NP_001377474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377474" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SU46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4L1", "type": "synonym", "evidence": [ { "id": "NP_001377474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377474" } ] }, { "name": "olfactory receptor family 4 subfamily L member 16", "type": "synonym", "evidence": [ { "id": "NP_001377474", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377474" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377474" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4L16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46", "locus": { "chromosome": "10", "start_pos": 27521199, "end_pos": 27520258, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061773", "url": "https://www.ensembl.org/id/ENSBTAG00000061773" } ] } } ], "crossref": [ { "id": "A0AAA9SU46", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU46", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788146", "url": "https://www.ncbi.nlm.nih.gov/gene/788146", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788146", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788146", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377474", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SU46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMMNSSMISEFVLLGLTNTWELELFFFFIFLLAYAAIMAGNLLIVVTITLDSHLHSTPMYFLLGNLSFLDMSVSTITTPKMIADFVRENKTISLWGCMAQMFFLHFLGGSEMTLLIVMAVDRYFAICKPLHYTTIMNHRVLRGSVLLSWAVGFVHTMSQMVFTITLPFCGPSIVDNIFCDLPLVIKLACTETYVLELLVIADSGLLSFISFILLLISYTVILVTIRHQSSGGLSKALSTLSAHITVVTLFFGPCIFIYAWPFSSFSVDKFLSVFYSVITPLLNPIIYTLRNQEMKAAMNRLRTQHVRSRKTF", "length": 313, "header": "tr|A0AAA9SU46-1|A0AAA9SU46_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4L16 PE=3 SV=1 CANONICAL=A0AAA9SU46-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46/entry#A0AAA9SU46-1", "sequence": { "sequence": "MKMMNSSMISEFVLLGLTNTWELELFFFFIFLLAYAAIMAGNLLIVVTITLDSHLHSTPMYFLLGNLSFLDMSVSTITTPKMIADFVRENKTISLWGCMAQMFFLHFLGGSEMTLLIVMAVDRYFAICKPLHYTTIMNHRVLRGSVLLSWAVGFVHTMSQMVFTITLPFCGPSIVDNIFCDLPLVIKLACTETYVLELLVIADSGLLSFISFILLLISYTVILVTIRHQSSGGLSKALSTLSAHITVVTLFFGPCIFIYAWPFSSFSVDKFLSVFYSVITPLLNPIIYTLRNQEMKAAMNRLRTQHVRSRKTF", "length": 313, "header": "tr|A0AAA9SU46-1|A0AAA9SU46_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4L16 PE=3 SV=1 CANONICAL=A0AAA9SU46-1" }, "locus": { "chromosome": "10", "start_pos": 27521196, "end_pos": 27520258, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095314.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095314.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087538.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788146", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788146", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SU46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU46" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 66, "end_pos": 68 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU51-1", "uniprot_ac": "A0AAA9SU51", "uniprot_id": "A0AAA9SU51_BOVIN", "mass": { "chemical_mass": 16414.0, "monoisotopic_mass": 16414.0 }, "refseq": {}, "gene_names": [ { "name": "ATG12", "type": "recommended", "evidence": [ { "id": "A0AAA9SU51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ] } ], "protein_names": [ { "name": "Ubiquitin-like protein ATG12", "type": "recommended", "evidence": [ { "id": "A0AAA9SU51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ubiquitin-like protein involved in autophagic vesicle formation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51#function" }, { "database": "UniProtKB", "id": "RU361201", "url": "https://www.uniprot.org/uniprotkb/RU361201#function" }, { "database": "UniProtKB", "id": "F1MZE2", "url": "https://www.uniprot.org/uniprotkb/F1MZE2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATG12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51", "locus": { "chromosome": "10", "start_pos": 4680213, "end_pos": 4702700, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017525", "url": "https://www.ensembl.org/id/ENSBTAG00000017525" } ] } } ], "crossref": [ { "id": "A0AAA9SU51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU51", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017525", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017525", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01612", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01612", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YAKTHAW", "url": "https://omabrowser.org/oma/group/YAKTHAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MZE2", "url": "https://www.orthodb.org/?gene=F1MZE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13385:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13385:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5205685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8934903", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934903", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZE2", "url": "https://www.uniprot.org/uniprotkb/F1MZE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZE2-1", "url": "https://www.uniprot.org/uniprotkb/F1MZE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEQESALQLPPSTAPEAEVPTEVSPETATPEPPSSAAVSPGTEEPVGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLPTVLVFLKKSLNVHAERSILEYRYREFWSSLCSGVNIAFFPFFSSLFT", "length": 148, "header": "tr|A0AAA9SU51-1|A0AAA9SU51_BOVIN Isoform 1 of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN=ATG12 PE=3 SV=1 CANONICAL=A0AAA9SU51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51/entry#A0AAA9SU51-1", "sequence": { "sequence": "MAEEQESALQLPPSTAPEAEVPTEVSPETATPEPPSSAAVSPGTEEPVGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLPTVLVFLKKSLNVHAERSILEYRYREFWSSLCSGVNIAFFPFFSSLFT", "length": 148, "header": "tr|A0AAA9SU51-1|A0AAA9SU51_BOVIN Isoform 1 of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN=ATG12 PE=3 SV=1 CANONICAL=A0AAA9SU51-1" }, "locus": { "chromosome": "10", "start_pos": 4702501, "end_pos": 4681999, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100953.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100953.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087543.1" } ] } }, { "isoform_ac": "A0AAA9TMX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51/entry#A0AAA9TMX7-1", "sequence": { "sequence": "MAEEQESALQLPPSTAPEAEVPTEVSPETATPEPPSSAAVSPGTEEPVGDTKKKIYLRESVLCPLPRPGSWDPL", "length": 74, "header": "tr|A0AAA9TMX7-1|A0AAA9TMX7_BOVIN Computationally mapped isoform of Autophagy related 12 OS=Bos taurus OX=9913 GN=ATG12 PE=4 SV=1 CANONICAL=A0AAA9SU51-1" }, "locus": { "chromosome": "10", "start_pos": 4702501, "end_pos": 4681950, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098601.1" } ] } }, { "isoform_ac": "F1MZE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51/entry#F1MZE2-1", "sequence": { "sequence": "MAEEQESALQLPPSTAPEAEVPTEVSPETATPEPPSSAAVSPGTEEPVGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 140, "header": "tr|F1MZE2-1|F1MZE2_BOVIN Computationally mapped isoform of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN=ATG12 PE=3 SV=3 CANONICAL=A0AAA9SU51-1" }, "locus": { "chromosome": "10", "start_pos": 4702501, "end_pos": 4681276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023301.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023301.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023301.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023301.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-5205685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "resource": "Reactome", "description": "PINK1-PRKN Mediated Mitophagy" }, { "id": "R-BTA-8934903", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934903", "resource": "Reactome", "description": "Receptor Mediated Mitophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "F1P145-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "ATG12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEAEEQAPVSPQSEGRSGAGEEAPERTPESGASLGVGEPATSPAGSPGTEDPAGDAKKKIDVLLKAVGDTPIMKTKKWAVERTRTIQGLCDFIKKFLKLMASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 146 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O94817-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "ATG12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEEPQSVLQLPTSIAAGGEGLTDVSPETTTPEPPSSAAVSPGTEEPAGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 140 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q2TBJ5-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "Atg12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEDPEAVLQLPAAPAAAAGESLLELSPETAIPEPPSSVAVSPGTEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTVQALIDFIRKFLRLLASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 141 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86CR6-1", "protein_name": "Ubiquitin-like protein atg12", "gene_name": "atg12", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEEEEKNNNEVASPTEQNTESTTEQQPQLPVKITSESKIIVYFKNAGGAQPLKQKKFKIQANVSFQNVIDKLRGQLKLKSNESLFLFINQVFQPSPDEILGELYKCFSHNDQLIINYSLQMAWG", "length": 124 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8S924-1", "protein_name": "Ubiquitin-like protein ATG12A", "gene_name": "ATG12A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATESSSPSSVRKVVVHLRATGGAPILKQSKFKIPGTDKFAKVIDFLRRQLHSDSLFVYVNSAFSPNPDESVIDLYNNFGFDGKLVVNYACSMAWG", "length": 96 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CQY1-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "Atg12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEDSEVVLQLPSAPVGAGGESLPELSPETATPEPPSSAAVSPGTEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 141 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VTU1-1", "protein_name": "Autophagy protein 12-like", "gene_name": "Atg12", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAETPESQAALSTSSSTPADKDGSKICILLNATGNVPIIKKRTWTVDPNKTVGWIQTFIHKFLKLDASEQIFLYVNQTFAPAPDQIIKNLYECHGTNGKLVLYYCKNQAWG", "length": 111 }, "evidence": [ { "id": "A0AAA9SU51", "url": "https://omabrowser.org/oma/group/A0AAA9SU51/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "glycophagy", "id": "GO:0061723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" }, { "name": "Atg12-Atg5-Atg16 complex", "id": "GO:0034274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034274", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tag activity", "id": "GO:0031386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU73-1", "uniprot_ac": "A0AAA9SU73", "uniprot_id": "A0AAA9SU73_BOVIN", "mass": { "chemical_mass": 16766.0, "monoisotopic_mass": 16766.0 }, "refseq": {}, "gene_names": [ { "name": "H2BN1", "type": "recommended", "evidence": [ { "id": "A0AAA9SU73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73" } ] } ], "protein_names": [ { "name": "Histone H2A/H2B/H3 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SU73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "H2BN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73", "locus": {} } ], "crossref": [ { "id": "A0AAA9SU73", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU73", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SU73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYFICLHGLQFPKRKLTIYIPAKEKDEWVHSATGKKRRKKKETYFNYMGKLLKQVHPDFSGCSWILDALRVLEDWQLEWVSLEAVRLSLYNHRRTITSREILEAVKQRCSQKSLGINEVDLHGSVVEMIALVQKQKIGSFGGLS", "length": 144, "header": "tr|A0AAA9SU73-1|A0AAA9SU73_BOVIN Isoform 1 of Histone H2A/H2B/H3 domain-containing protein OS=Bos taurus OX=9913 GN=H2BN1 PE=3 SV=1 CANONICAL=A0AAA9SU73-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73/entry#A0AAA9SU73-1", "sequence": { "sequence": "MYFICLHGLQFPKRKLTIYIPAKEKDEWVHSATGKKRRKKKETYFNYMGKLLKQVHPDFSGCSWILDALRVLEDWQLEWVSLEAVRLSLYNHRRTITSREILEAVKQRCSQKSLGINEVDLHGSVVEMIALVQKQKIGSFGGLS", "length": 144, "header": "tr|A0AAA9SU73-1|A0AAA9SU73_BOVIN Isoform 1 of Histone H2A/H2B/H3 domain-containing protein OS=Bos taurus OX=9913 GN=H2BN1 PE=3 SV=1 CANONICAL=A0AAA9SU73-1" }, "locus": { "chromosome": "19", "start_pos": 17318442, "end_pos": 17314140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130006.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130006.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089980.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU74-1", "uniprot_ac": "A0AAA9SU74", "uniprot_id": "A0AAA9SU74_BOVIN", "mass": { "chemical_mass": 21321.0, "monoisotopic_mass": 21321.0 }, "refseq": {}, "gene_names": [ { "name": "WASHC3", "type": "recommended", "evidence": [ { "id": "A0AAA9SU74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74" } ] } ], "protein_names": [ { "name": "WASH complex subunit 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SU74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 53", "type": "synonym", "evidence": [ { "id": "A0AAA9SU74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WASHC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74", "locus": { "chromosome": "5", "start_pos": 65822002, "end_pos": 65892313, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000021", "url": "https://www.ensembl.org/id/ENSBTAG00000000021" } ] } } ], "crossref": [ { "id": "A0AAA9SU74", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU74", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GCETKFV", "url": "https://omabrowser.org/oma/group/GCETKFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBF8", "url": "https://www.orthodb.org/?gene=F1MBF8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13015", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13015", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13015:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13015:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10152", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10152", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SU74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBF8", "url": "https://www.uniprot.org/uniprotkb/F1MBF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBF8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEKNTEESSDSESSFSD", "length": 194, "header": "tr|A0AAA9SU74-1|A0AAA9SU74_BOVIN Isoform 1 of WASH complex subunit 3 OS=Bos taurus OX=9913 GN=WASHC3 PE=3 SV=1 CANONICAL=A0AAA9SU74-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#A0AAA9SU74-1", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEKNTEESSDSESSFSD", "length": 194, "header": "tr|A0AAA9SU74-1|A0AAA9SU74_BOVIN Isoform 1 of WASH complex subunit 3 OS=Bos taurus OX=9913 GN=WASHC3 PE=3 SV=1 CANONICAL=A0AAA9SU74-1" }, "locus": { "chromosome": "5", "start_pos": 65886797, "end_pos": 65828337, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130284.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130284.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087699.1" } ] } }, { "isoform_ac": "A0AAA9T7Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#A0AAA9T7Q5-1", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLDIVPFLPVLHFFSLRPSPSSFSYF", "length": 190, "header": "tr|A0AAA9T7Q5-1|A0AAA9T7Q5_BOVIN Computationally mapped isoform of WASH complex subunit 3 OS=Bos taurus OX=9913 GN=WASHC3 PE=3 SV=1 CANONICAL=A0AAA9SU74-1" }, "locus": { "chromosome": "5", "start_pos": 65886797, "end_pos": 65850270, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093966.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093966.1" } ] } }, { "isoform_ac": "A0AAA9TLJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#A0AAA9TLJ6-1", "sequence": { "sequence": "MCLHVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEKNTEESSDSESSFSD", "length": 181, "header": "tr|A0AAA9TLJ6-1|A0AAA9TLJ6_BOVIN Computationally mapped isoform of WASH complex subunit 3 OS=Bos taurus OX=9913 GN=WASHC3 PE=3 SV=1 CANONICAL=A0AAA9SU74-1" }, "locus": { "chromosome": "5", "start_pos": 65892138, "end_pos": 65828337, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098085.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098085.1" } ] } }, { "isoform_ac": "A0AAA9TRA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#A0AAA9TRA4-1", "sequence": { "sequence": "MPLLLPFPSHEFLCSRVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEKNTEESSDSESSFSD", "length": 193, "header": "tr|A0AAA9TRA4-1|A0AAA9TRA4_BOVIN Computationally mapped isoform of WASH complex subunit 3 OS=Bos taurus OX=9913 GN=WASHC3 PE=3 SV=1 CANONICAL=A0AAA9SU74-1" }, "locus": { "chromosome": "5", "start_pos": 65886552, "end_pos": 65828337, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109513.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109513.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099841.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099841.1" } ] } }, { "isoform_ac": "F1MBF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74/entry#F1MBF8-1", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPVNVTRITNGTHSEATSEQSQQNSLQDSGPQESEVTPENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEIPRN", "length": 183, "header": "tr|F1MBF8-1|F1MBF8_BOVIN Computationally mapped isoform of WASH complex subunit 3 OS=Bos taurus OX=9913 GN=WASHC3 PE=3 SV=2 CANONICAL=A0AAA9SU74-1" }, "locus": { "chromosome": "5", "start_pos": 65886797, "end_pos": 65822051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000022.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000022.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000022.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000022.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T5A1-1", "protein_name": "WASH complex subunit 3", "gene_name": "WASHC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTFEVSPISVTRITNESHSETTSEQLQQNSFQDSGPQESEVTPENTLTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGEGEKNTEESSDSESSFSD", "length": 194 }, "evidence": [ { "id": "A0AAA9SU74", "url": "https://omabrowser.org/oma/group/A0AAA9SU74/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZKX1-1", "protein_name": "WASH complex subunit 3", "gene_name": "Washc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVDMSPLSVTAVTNGSHSETTAEQLQQNSTQDSGVQQGEAPSENVLTVAKDPRYARYLKMVQVGVPVMAIRDKMISEGLDPELLEKPDAPVPSGESEKAIEESSESTQVPQVSHSILTCWRDDKSHRRCKYFLWLRALENPISRSHKLRL", "length": 232 }, "evidence": [ { "id": "A0AAA9SU74", "url": "https://omabrowser.org/oma/group/A0AAA9SU74/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5RGJ6-1", "protein_name": "WASH complex subunit 3", "gene_name": "washc3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDADGLPIVGSGVDLTKVPAIQQRRIVAFLNQFIVHTVRFLNRFSTVCEEKLSTVSLRIQQIETTLSILEAKLASIPGLEEVTVDGVRAPAETNGPAADTSRATAPPAEASQQTQAAPQEPKTEAPAENIMTVAKDPRYARYLKMVQVGVPVMAIKNKMMMEGLDPNLLDTPDAAVPDASKKRLEEQDDDSSGSESSFSD", "length": 200 }, "evidence": [ { "id": "A0AAA9SU74", "url": "https://omabrowser.org/oma/group/A0AAA9SU74/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CR27-1", "protein_name": "WASH complex subunit 3", "gene_name": "Washc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSAVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLEDVTVEVSPLNVTAVTNGSHSETTSEQTQQNSTQDSGAQESEAPSENVLTVAKDPRYARYLKMVQVGVPVMAIRDKMISEGLDPELLEKPDAPVPNGESERAVEESSDSDSSFSD", "length": 194 }, "evidence": [ { "id": "A0AAA9SU74", "url": "https://omabrowser.org/oma/group/A0AAA9SU74/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VLT8-1", "protein_name": "WASH complex subunit 3", "gene_name": "CCDC53", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDATAAITGNVDKTQIPPLNQKRILAFVNHFLVSTCTFLNEFALGCETKFVEMERQLQKTEAALIILEAKLASIPTEHHVATEATEAPAISNQQRNEEASMVDTTEPPTTENPTEPELPPESVGVRACEDQRYRKFFKMVQVGVPAPAVKQKMQSEGLEPRILDTPDLILADGQRE", "length": 176 }, "evidence": [ { "id": "A0AAA9SU74", "url": "https://omabrowser.org/oma/group/A0AAA9SU74/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y3C0-1", "protein_name": "WASH complex subunit 3", "gene_name": "WASHC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGESEKTVEESSDSESSFSD", "length": 194 }, "evidence": [ { "id": "A0AAA9SU74", "url": "https://omabrowser.org/oma/group/A0AAA9SU74/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "WASH complex", "id": "GO:0071203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin filament polymerization", "id": "GO:0030041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU76-1", "uniprot_ac": "A0AAA9SU76", "uniprot_id": "A0AAA9SU76_BOVIN", "mass": { "chemical_mass": 24608.0, "monoisotopic_mass": 24608.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM126A", "type": "recommended", "evidence": [ { "id": "A0AAA9SU76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ] } ], "protein_names": [ { "name": "Transmembrane protein 126A", "type": "recommended", "evidence": [ { "id": "A0AAA9SU76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YGW3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGW3#function" }, { "database": "UniProtKB", "id": "ARBA00045919", "url": "https://www.uniprot.org/uniprotkb/ARBA00045919#function" }, { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM126A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76", "locus": { "chromosome": "29", "start_pos": 9897293, "end_pos": 9906615, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000451", "url": "https://www.ensembl.org/id/ENSBTAG00000000451" } ] } } ], "crossref": [ { "id": "A0AAA9SU76", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU76", "database": "AlphaFoldDB", "categories": [] }, { "id": "529762", "url": "https://www.ncbi.nlm.nih.gov/gene/529762", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16296:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16296:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGW3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YGW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YGW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISQTAIGAQDPMENVKSMEQRNLRLKMENHEPDGTIIKENLTDIIARKINQLPEAERNLLENGSTYVGLNAALCGLIANSLFRRILHVTQARIAAGLPMAVIPFLTANVSYKGFVSLPLNTGDLQCETCTVTRGGLVGLVFGGLYPVFLAIPVNGGLAARYNSALLPEKGNILNYWIRISKPVFRKMLFPILLQTGFAAYLGSRQYKLLIKALQLPEPGLEIE", "length": 224, "header": "tr|A0AAA9SU76-1|A0AAA9SU76_BOVIN Isoform 1 of Transmembrane protein 126A OS=Bos taurus OX=9913 GN=TMEM126A PE=3 SV=1 CANONICAL=A0AAA9SU76-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76/entry#A0AAA9SU76-1", "sequence": { "sequence": "MISQTAIGAQDPMENVKSMEQRNLRLKMENHEPDGTIIKENLTDIIARKINQLPEAERNLLENGSTYVGLNAALCGLIANSLFRRILHVTQARIAAGLPMAVIPFLTANVSYKGFVSLPLNTGDLQCETCTVTRGGLVGLVFGGLYPVFLAIPVNGGLAARYNSALLPEKGNILNYWIRISKPVFRKMLFPILLQTGFAAYLGSRQYKLLIKALQLPEPGLEIE", "length": 224, "header": "tr|A0AAA9SU76-1|A0AAA9SU76_BOVIN Isoform 1 of Transmembrane protein 126A OS=Bos taurus OX=9913 GN=TMEM126A PE=3 SV=1 CANONICAL=A0AAA9SU76-1" }, "locus": { "chromosome": "29", "start_pos": 9906342, "end_pos": 9897315, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115487.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115487.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087569.1" } ] } }, { "isoform_ac": "A0AAF6YGW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76/entry#A0AAF6YGW3-1", "sequence": { "sequence": "MTLCSAAAWLKMENHEPDGTIIKENLTDIIARKINQLPEAERNLLENGSTYVGLNAALCGLIANSLFRRILHVTQARIAAGLPMAVIPFLTANVSYKGFVSLPLNTGDLQCETCTVTRGGLVGLVFGGLYPVFLAIPVNGGLAARYNSALLPEKGNILNYWIRISKPVFRKMLFPILLQTGFAAYLGSRQYKLLIKALQLPEPGLEIE", "length": 208, "header": "tr|A0AAF6YGW3-1|A0AAF6YGW3_BOVIN Computationally mapped isoform of Transmembrane protein 126A OS=Bos taurus OX=9913 GN=TMEM126A PE=3 SV=1 CANONICAL=A0AAA9SU76-1" }, "locus": { "chromosome": "29", "start_pos": 9905685, "end_pos": 9897315, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000576.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000576.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000576.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000576.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "pmid": "" }, { "name": "optic nerve development", "id": "GO:0021554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021554", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane from matrix", "id": "GO:0032979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "pmid": "" }, { "name": "mitochondrial protein quality control", "id": "GO:0141164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141164", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU86-1", "uniprot_ac": "A0AAA9SU86", "uniprot_id": "A0AAA9SU86_BOVIN", "mass": { "chemical_mass": 38524.0, "monoisotopic_mass": 38524.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Tripartite motif containing 40", "type": "synonym", "evidence": [ { "id": "A0AAA9SU86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86", "locus": {} } ], "crossref": [ { "id": "A0AAA9SU86", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU86", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16583", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16583", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SU86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSLREDRQEEGICPICQECLKEAVRTDCGHLFCRACLAQHLEKASASGVRSCPLCRKPCSEGVLGAGYTCDSPQKKAYWFCEESRRLLCMECRVTPEHKSHCELPIENAISHYKERTLRDSNSVTTNSAVAYTVSENLSEEFSGIFTQKRDHRIIEKRLNRRIRRRRQLRIQEEILQEMQFQADHGTHRLEAELEQQPQTRRQLDAPAQQRPDQRRDVSAELSRSPGISRALLQFSSLVTDPEGMAKKLDTSLLKDAGDLLNRSAPEQLEAIYPNLEERINESLVQPSSAALTCSSLGHLISDSPHPPGSPSPNLSSLPLGLPDGPSDLPSPEHDLHSSSPEL", "length": 344, "header": "tr|A0AAA9SU86-1|A0AAA9SU86_BOVIN Isoform 1 of Tripartite motif containing 40 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SU86-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86/entry#A0AAA9SU86-1", "sequence": { "sequence": "MGSLREDRQEEGICPICQECLKEAVRTDCGHLFCRACLAQHLEKASASGVRSCPLCRKPCSEGVLGAGYTCDSPQKKAYWFCEESRRLLCMECRVTPEHKSHCELPIENAISHYKERTLRDSNSVTTNSAVAYTVSENLSEEFSGIFTQKRDHRIIEKRLNRRIRRRRQLRIQEEILQEMQFQADHGTHRLEAELEQQPQTRRQLDAPAQQRPDQRRDVSAELSRSPGISRALLQFSSLVTDPEGMAKKLDTSLLKDAGDLLNRSAPEQLEAIYPNLEERINESLVQPSSAALTCSSLGHLISDSPHPPGSPSPNLSSLPLGLPDGPSDLPSPEHDLHSSSPEL", "length": 344, "header": "tr|A0AAA9SU86-1|A0AAA9SU86_BOVIN Isoform 1 of Tripartite motif containing 40 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SU86-1" }, "locus": { "chromosome": "23", "start_pos": 28840652, "end_pos": 28829097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086680.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SU86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 107, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SU86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU86" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 57, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 263, "end_pos": 265 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 315, "end_pos": 317 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU95-1", "uniprot_ac": "A0AAA9SU95", "uniprot_id": "A0AAA9SU95_BOVIN", "mass": { "chemical_mass": 17544.0, "monoisotopic_mass": 17544.0 }, "refseq": { "ac": "XP_002694209", "name": "protein FAM163A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694209" }, "gene_names": [ { "name": "FAM163A", "type": "recommended", "evidence": [ { "id": "A0AAA9SU95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95" } ] }, { "name": "FAM163A", "type": "synonym", "evidence": [ { "id": "XP_002694209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694209" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 163 member A", "type": "synonym", "evidence": [ { "id": "A0AAA9SU95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95/entry#names_and_taxonomy" } ] }, { "name": "protein FAM163A", "type": "synonym", "evidence": [ { "id": "XP_002694209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694209" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM163A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95", "locus": { "chromosome": "16", "start_pos": 61032846, "end_pos": 60937582, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069796", "url": "https://www.ensembl.org/id/ENSBTAG00000069796" } ] } } ], "crossref": [ { "id": "A0AAA9SU95", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU95", "database": "AlphaFoldDB", "categories": [] }, { "id": "613476", "url": "https://www.ncbi.nlm.nih.gov/gene/613476", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613476", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613476", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGQPCGV", "url": "https://omabrowser.org/oma/group/CGQPCGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31914", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31914", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31914:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31914:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694209", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694209", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SU95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSRAEDADEEGEEEHDLPTHPRGPACNACSSQALDGRGSLAPVPGEPCGQPCRVAAGHCTACSPYSSPFYIRTADMVPNGGGGERLSFAPTYYKEGGPPSLQVAAPQSYPVTWPGSGREAFTNPRAISTDV", "length": 167, "header": "tr|A0AAA9SU95-1|A0AAA9SU95_BOVIN Isoform 1 of Family with sequence similarity 163 member A OS=Bos taurus OX=9913 GN=FAM163A PE=3 SV=1 CANONICAL=A0AAA9SU95-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95/entry#A0AAA9SU95-1", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSRAEDADEEGEEEHDLPTHPRGPACNACSSQALDGRGSLAPVPGEPCGQPCRVAAGHCTACSPYSSPFYIRTADMVPNGGGGERLSFAPTYYKEGGPPSLQVAAPQSYPVTWPGSGREAFTNPRAISTDV", "length": 167, "header": "tr|A0AAA9SU95-1|A0AAA9SU95_BOVIN Isoform 1 of Family with sequence similarity 163 member A OS=Bos taurus OX=9913 GN=FAM163A PE=3 SV=1 CANONICAL=A0AAA9SU95-1" }, "locus": { "chromosome": "16", "start_pos": 61031842, "end_pos": 61030543, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114897.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114897.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086693.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613476", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613476", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AIB4-1", "protein_name": "Family with sequence similarity 163 member A", "gene_name": "FAM163A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSRAEDADDEEEEHDLPTHPRGPPCNACSSQALDGQGGLAPLPSEPCGQPCGVAASHCTTCSPYSSPFYIRTADMVPNGGGGERLPFAPTYYKEGGPPSLKVAAPQSYPVTWPGSGREAFTNPRAISTDV", "length": 166 }, "evidence": [ { "id": "A0AAA9SU95", "url": "https://omabrowser.org/oma/group/A0AAA9SU95/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A5WWK4-1", "protein_name": "Protein FAM163A", "gene_name": "fam163ab", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTAGTVVITGGILAAVILLCIIVVLCYCRLQYYCCKKHGSDPDAVCPQPQLSYGVDGMVCAPLSPSPDSNFCPSCSPYSSTFYIHNGGERLIYLPSQYSNTRAMSTDV", "length": 108 }, "evidence": [ { "id": "A0AAA9SU95", "url": "https://omabrowser.org/oma/group/A0AAA9SU95/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZIK4-1", "protein_name": "Family with sequence similarity 163, member A", "gene_name": "Fam163a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKGTDDEEAEEEEEAEEHDLSLHPRAPTCNACSSQVLDGRGSLAPLTSESCSQPCGVASHCTTCSPYRTPFYIRTADMVPNGGGGERLSFAPTYYKEGGTPSLKLAAPQSYPVTWPSSGHEAFTNPRAISTDV", "length": 168 }, "evidence": [ { "id": "A0AAA9SU95", "url": "https://omabrowser.org/oma/group/A0AAA9SU95/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BS52-1", "protein_name": "Family with sequence similarity 163 member A", "gene_name": "FAM163A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDDPNEEEEEEEEEEEESDLPTHSHPGTCNACSSRMADGQGSPTPIPELNQHGAHPRCPTCSPYGSPFYIRTPDMVRNGGERVAYAPACYPEMGPPVGLQGFPLSRHGLREGFPPSRAISTEV", "length": 159 }, "evidence": [ { "id": "A0AAA9SU95", "url": "https://omabrowser.org/oma/group/A0AAA9SU95/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8CAA5-1", "protein_name": "Protein FAM163A", "gene_name": "Fam163a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKGTDGEDAEEEEEEEEHGLSIHPRVPACNACSSHVLDGRGGLAPLTSESCSQPCGVASHCTTCSPYRTPFYIRTADMVPNGGGGERLSFAPTHYKEGGTPSLKLAAPQNYPVTWPSSGHEAFTNPRAISTDV", "length": 168 }, "evidence": [ { "id": "A0AAA9SU95", "url": "https://omabrowser.org/oma/group/A0AAA9SU95/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96GL9-1", "protein_name": "Protein FAM163A", "gene_name": "FAM163A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSGTEVADEEEEREHDLPTHPRGPTCNACSSQALDGRGSLAPLTSEPCSQPCGVAASHCTTCSPYSSPFYIRTADMVPNGGGGERLSFAPTYYKEGGPPSLKLAAPQSYPVTWPGSGREAFTNPRAISTDV", "length": 167 }, "evidence": [ { "id": "A0AAA9SU95", "url": "https://omabrowser.org/oma/group/A0AAA9SU95/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU95" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUA3-1", "uniprot_ac": "A0AAA9SUA3", "uniprot_id": "A0AAA9SUA3_BOVIN", "mass": { "chemical_mass": 30204.0, "monoisotopic_mass": 30204.0 }, "refseq": {}, "gene_names": [ { "name": "OR10H1I", "type": "recommended", "evidence": [ { "id": "A0AAA9SUA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3" } ] } ], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SUA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10H1I", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3", "locus": { "chromosome": "7", "start_pos": 7232597, "end_pos": 7231650, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006216", "url": "https://www.ensembl.org/id/ENSBTAG00000006216" } ] } } ], "crossref": [ { "id": "A0AAA9SUA3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYLFTLLGNLLIMATVWREHSLHTPMYLFLCALSISEILYTFAVIPRMLADLLSTDHSIALRACASQMFFSFTFGFTHSFLLTIMGYDRYVAICHPLRYNVLMSPRGCACLVAWSWAGGSVIGLVVTVAIFQLTFCGSNEIHHFVCHVQALLKLACGENVSILAMGLGLVCIAALLGCCLLILLSYAFIVATILKIPSAEGRHKAFSTCVSHLTVVIEHYGFASVIYLKPKGPQSLEIDTLMGITYTVLTPFLSPIIFSLRNKELKIAMKKTF", "length": 273, "header": "tr|A0AAA9SUA3-1|A0AAA9SUA3_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=OR10H1I PE=3 SV=1 CANONICAL=A0AAA9SUA3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3/entry#A0AAA9SUA3-1", "sequence": { "sequence": "MYLFTLLGNLLIMATVWREHSLHTPMYLFLCALSISEILYTFAVIPRMLADLLSTDHSIALRACASQMFFSFTFGFTHSFLLTIMGYDRYVAICHPLRYNVLMSPRGCACLVAWSWAGGSVIGLVVTVAIFQLTFCGSNEIHHFVCHVQALLKLACGENVSILAMGLGLVCIAALLGCCLLILLSYAFIVATILKIPSAEGRHKAFSTCVSHLTVVIEHYGFASVIYLKPKGPQSLEIDTLMGITYTVLTPFLSPIIFSLRNKELKIAMKKTF", "length": 273, "header": "tr|A0AAA9SUA3-1|A0AAA9SUA3_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=OR10H1I PE=3 SV=1 CANONICAL=A0AAA9SUA3-1" }, "locus": { "chromosome": "7", "start_pos": 7307068, "end_pos": 7306250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110142.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110142.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090016.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090016.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 258, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUH5-1", "uniprot_ac": "A0AAA9SUH5", "uniprot_id": "A0AAA9SUH5_BOVIN", "mass": { "chemical_mass": 20608.0, "monoisotopic_mass": 20608.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM140", "type": "recommended", "evidence": [ { "id": "A0AAA9SUH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5" } ] } ], "protein_names": [ { "name": "Transmembrane protein 140", "type": "synonym", "evidence": [ { "id": "A0AAA9SUH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM140", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5", "locus": { "chromosome": "4", "start_pos": 98820231, "end_pos": 98798281, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064655", "url": "https://www.ensembl.org/id/ENSBTAG00000064655" } ] } } ], "crossref": [ { "id": "IPR028038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16103:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16103:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14985", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14985", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMTVLKSKRRSQLLFLVTMTLTITTICLLFFALLWKAGNLVDLPNLRVGFYNFCLWHEGTGALQCYQFPELEALGVPRVGLALARLGVYGALVLTLFVPLPFLLAWCNNNEGEWQLAVGFLATSSVLLASGLGLFLTYTWKWLQLSLLGPGSLALGAAQTLLILLLVATAVFPQRAKDRSWGATSSV", "length": 188, "header": "tr|A0AAA9SUH5-1|A0AAA9SUH5_BOVIN Isoform 1 of Transmembrane protein 140 OS=Bos taurus OX=9913 GN=TMEM140 PE=4 SV=1 CANONICAL=A0AAA9SUH5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUH5/entry#A0AAA9SUH5-1", "sequence": { "sequence": "MKMTVLKSKRRSQLLFLVTMTLTITTICLLFFALLWKAGNLVDLPNLRVGFYNFCLWHEGTGALQCYQFPELEALGVPRVGLALARLGVYGALVLTLFVPLPFLLAWCNNNEGEWQLAVGFLATSSVLLASGLGLFLTYTWKWLQLSLLGPGSLALGAAQTLLILLLVATAVFPQRAKDRSWGATSSV", "length": 188, "header": "tr|A0AAA9SUH5-1|A0AAA9SUH5_BOVIN Isoform 1 of Transmembrane protein 140 OS=Bos taurus OX=9913 GN=TMEM140 PE=4 SV=1 CANONICAL=A0AAA9SUH5-1" }, "locus": { "chromosome": "4", "start_pos": 98819729, "end_pos": 98819166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131503.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131503.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081234.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUI3-1", "uniprot_ac": "A0AAA9SUI3", "uniprot_id": "A0AAA9SUI3_BOVIN", "mass": { "chemical_mass": 12114.0, "monoisotopic_mass": 12114.0 }, "refseq": {}, "gene_names": [ { "name": "GTF2A2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ] } ], "protein_names": [ { "name": "Transcription initiation factor IIA subunit 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3#function" }, { "database": "UniProtKB", "id": "ARBA00024733", "url": "https://www.uniprot.org/uniprotkb/ARBA00024733#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF2A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3", "locus": { "chromosome": "10", "start_pos": 50615679, "end_pos": 50607673, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010298", "url": "https://www.ensembl.org/id/ENSBTAG00000010298" } ] } } ], "crossref": [ { "id": "A0AAA9SUI3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10014", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10014", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10145", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10145", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02751", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02751", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P739", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P739", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P739-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P739-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYQLYRNTTLGNSLQESLDELIQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE", "length": 106, "header": "tr|A0AAA9SUI3-1|A0AAA9SUI3_BOVIN Isoform 1 of Transcription initiation factor IIA subunit 2 OS=Bos taurus OX=9913 GN=GTF2A2 PE=3 SV=2 CANONICAL=A0AAA9SUI3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3/entry#A0AAA9SUI3-1", "sequence": { "sequence": "MAYQLYRNTTLGNSLQESLDELIQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE", "length": 106, "header": "tr|A0AAA9SUI3-1|A0AAA9SUI3_BOVIN Isoform 1 of Transcription initiation factor IIA subunit 2 OS=Bos taurus OX=9913 GN=GTF2A2 PE=3 SV=2 CANONICAL=A0AAA9SUI3-1" }, "locus": { "chromosome": "10", "start_pos": 50614671, "end_pos": 50607703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123995.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123995.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086800.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086800.2" } ] } }, { "isoform_ac": "A0AAA9TPC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3/entry#A0AAA9TPC6-1", "sequence": { "sequence": "MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRILARILQNE", "length": 68, "header": "tr|A0AAA9TPC6-1|A0AAA9TPC6_BOVIN Computationally mapped isoform of Transcription initiation factor IIA gamma chain OS=Bos taurus OX=9913 GN=GTF2A2 PE=3 SV=1 CANONICAL=A0AAA9SUI3-1" }, "locus": { "chromosome": "10", "start_pos": 50614675, "end_pos": 50607703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097910.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097910.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099122.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099122.1" } ] } }, { "isoform_ac": "A0ABI0P739-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3/entry#A0ABI0P739-1", "sequence": { "sequence": "MAYQLYRNTTLGNSLQESLDELIQGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE", "length": 74, "header": "tr|A0ABI0P739-1|A0ABI0P739_BOVIN Computationally mapped isoform of Transcription initiation factor IIA gamma chain OS=Bos taurus OX=9913 GN=GTF2A2 PE=3 SV=1 CANONICAL=A0AAA9SUI3-1" }, "locus": { "chromosome": "10", "start_pos": 50614671, "end_pos": 50607703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138010.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138010.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107439.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107439.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of transcription initiation by RNA polymerase II", "id": "GO:0060261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "RNA polymerase II preinitiation complex assembly", "id": "GO:0051123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase II promoter", "id": "GO:0006367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "TBP-class protein binding", "id": "GO:0017025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor binding", "id": "GO:0001091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "transcription factor TFIIA complex", "id": "GO:0005672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" }, { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" }, { "id": "PF02751", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02751" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transcription initiation factor IIA gamma subunit C-terminal", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 97, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI3" }, { "id": "PF02268", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transcription initiation factor IIA gamma subunit N-terminal", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 45, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUI6-1", "uniprot_ac": "A0AAA9SUI6", "uniprot_id": "A0AAA9SUI6_BOVIN", "mass": { "chemical_mass": 35679.0, "monoisotopic_mass": 35679.0 }, "refseq": { "ac": "NP_001178984", "name": "hairy/enhancer-of-split related with YRPW motif protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178984" }, "gene_names": [ { "name": "HEY2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ] }, { "name": "HEY2", "type": "synonym", "evidence": [ { "id": "NP_001178984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178984" } ] } ], "protein_names": [ { "name": "Hes related family bHLH transcription factor with YRPW motif 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SUI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6/entry#names_and_taxonomy" } ] }, { "name": "hairy/enhancer-of-split related with YRPW motif 2", "type": "synonym", "evidence": [ { "id": "NP_001178984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178984" } ] }, { "name": "hairy/enhancer-of-split related with YRPW motif protein 2", "type": "synonym", "evidence": [ { "id": "NP_001178984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178984" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6", "locus": { "chromosome": "9", "start_pos": 25550030, "end_pos": 25561293, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000919", "url": "https://www.ensembl.org/id/ENSBTAG00000000919" } ] } } ], "crossref": [ { "id": "A0AAA9SUI6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000919", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000919", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18920", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18920", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538619", "url": "https://www.ncbi.nlm.nih.gov/gene/538619", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538619", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538619", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DTTPCRL", "url": "https://omabrowser.org/oma/group/DTTPCRL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEV8", "url": "https://www.orthodb.org/?gene=E1BEV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178984", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEV8", "url": "https://www.uniprot.org/uniprotkb/E1BEV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEV8-1", "url": "https://www.uniprot.org/uniprotkb/E1BEV8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSSCASQREAAAMTSSLAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQQTGSGTNSKPYRPWGTEVGAF", "length": 337, "header": "tr|A0AAA9SUI6-1|A0AAA9SUI6_BOVIN Isoform 1 of Hes related family bHLH transcription factor with YRPW motif 2 OS=Bos taurus OX=9913 GN=HEY2 PE=3 SV=1 CANONICAL=A0AAA9SUI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6/entry#A0AAA9SUI6-1", "sequence": { "sequence": "MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSSCASQREAAAMTSSLAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQQTGSGTNSKPYRPWGTEVGAF", "length": 337, "header": "tr|A0AAA9SUI6-1|A0AAA9SUI6_BOVIN Isoform 1 of Hes related family bHLH transcription factor with YRPW motif 2 OS=Bos taurus OX=9913 GN=HEY2 PE=3 SV=1 CANONICAL=A0AAA9SUI6-1" }, "locus": { "chromosome": "9", "start_pos": 25561094, "end_pos": 25551458, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110989.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110989.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086805.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086805.1" } ] } }, { "isoform_ac": "E1BEV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6/entry#E1BEV8-1", "sequence": { "sequence": "MWVCTRGVGREDGGRGWKCAGAGEGGSPGCQRWTRGLACPGDPATHPPPKLQSTSSVIRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSSCASQREAAAMTSSLAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQQTGSGTNSKPYRPWGTEVGAF", "length": 360, "header": "tr|E1BEV8-1|E1BEV8_BOVIN Computationally mapped isoform of Hes related family bHLH transcription factor with YRPW motif 2 OS=Bos taurus OX=9913 GN=HEY2 PE=3 SV=3 CANONICAL=A0AAA9SUI6-1" }, "locus": { "chromosome": "9", "start_pos": 25560828, "end_pos": 25551458, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001214.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001214.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001214.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001214.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538619", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538619", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PW12-1", "protein_name": "Hes related family bHLH transcription factor with YRPW motif 2", "gene_name": "HEY2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRPCEETTSDSDMDETIDVGSENNYCGQSHSSVLRPNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHSLAMDFMSIGFRECLTEVARYLTSVEGLDTSDPLRVRLVSHLSTCASQREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHAPEAAPCRLSSEVPPHGSALLTATFAHTDAALRVPSAGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAQSFPLSFTSTFPMLPPSAAAAAVAAATAITPPLAVSASSSPQQAGSGASGKPYRPWGTEVGAF", "length": 335 }, "evidence": [ { "id": "A0AAA9SUI6", "url": "https://omabrowser.org/oma/group/A0AAA9SUI6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S2V4-1", "protein_name": "Hes related family bHLH transcription factor with YRPW motif 2", "gene_name": "HEY2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCASQREAAAMTSSLAHHHHPLHPHHWAAAFHHLPAALFQPSGLHTSESTPCRLSTASEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF", "length": 337 }, "evidence": [ { "id": "A0AAA9SUI6", "url": "https://omabrowser.org/oma/group/A0AAA9SUI6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V7S6-1", "protein_name": "Hes-related family bHLH transcription factor with YRPW motif 2", "gene_name": "Hey2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKRPCEETTSESDLDETIDVGSENNYSGHSASSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMSHHHHPLHPHHWAAAFHHLPTSLLQPNGLHTSESTPCRLSTSSEVPPAHGSALLTATFAHADSALRMPSTGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSSGTNSKPYRPWGTEVGAF", "length": 339 }, "evidence": [ { "id": "A0AAA9SUI6", "url": "https://omabrowser.org/oma/group/A0AAA9SUI6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9I9L0-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "hey2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKRPCEDSTSDSDMDETIDVGSENNYSGQSNGSFIRCGSPTTTSQVMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHSLAMDFLSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSSCASQREAAAMTTSIAHHQQALHPHHWAAALHPIPAAFLQQSGLPSSESSSGRLSEAPQRGAALFSHSDSALRAPSTGSVAPCVPPLSTSLLSLSATVHAAAAAAAAQTFPLSFPAGFPLFSPSVTASSVASSTVSSSVSTSTTSQQSSGSSSKPYRPWGTEVGAF", "length": 324 }, "evidence": [ { "id": "A0AAA9SUI6", "url": "https://omabrowser.org/oma/group/A0AAA9SUI6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9QUS4-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "Hey2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRPCEETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHGSALLTATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSTGTNNKPYQPWGTEVGAF", "length": 339 }, "evidence": [ { "id": "A0AAA9SUI6", "url": "https://omabrowser.org/oma/group/A0AAA9SUI6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF", "length": 337 }, "evidence": [ { "id": "A0AAA9SUI6", "url": "https://omabrowser.org/oma/group/A0AAA9SUI6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 33, "go_terms": [ { "name": "circulatory system development", "id": "GO:0072359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "dorsal aorta morphogenesis", "id": "GO:0035912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell differentiation", "id": "GO:0051151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051151", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "vascular associated smooth muscle cell development", "id": "GO:0097084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097084", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "cardiac epithelial to mesenchymal transition", "id": "GO:0060317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060317", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "heart trabecula formation", "id": "GO:0060347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060347", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "labyrinthine layer blood vessel development", "id": "GO:0060716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060716", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "outflow tract morphogenesis", "id": "GO:0003151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003151", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "ventricular cardiac muscle cell development", "id": "GO:0055015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "pulmonary artery morphogenesis", "id": "GO:0061156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "mesenchymal cell development", "id": "GO:0014031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "aortic valve morphogenesis", "id": "GO:0003180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003180", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "pulmonary valve morphogenesis", "id": "GO:0003184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "tricuspid valve morphogenesis", "id": "GO:0003186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "cardiac right ventricle morphogenesis", "id": "GO:0003215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003215", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "atrial septum morphogenesis", "id": "GO:0060413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060413", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "cardiac left ventricle morphogenesis", "id": "GO:0003214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "negative regulation of transcription initiation by RNA polymerase II", "id": "GO:0060633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060633", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "negative regulation of biomineral tissue development", "id": "GO:0070168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "muscular septum morphogenesis", "id": "GO:0003150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003150", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "regulation of vasculogenesis", "id": "GO:2001212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "ascending aorta morphogenesis", "id": "GO:0035910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035910", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "umbilical cord morphogenesis", "id": "GO:0036304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036304", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "arterial endothelial cell differentiation", "id": "GO:0060842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060842", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" }, { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUI6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 103, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI6" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 157, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 25, "end_pos": 27 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUK5-1", "uniprot_ac": "A0AAA9SUK5", "uniprot_id": "A0AAA9SUK5_BOVIN", "mass": { "chemical_mass": 33619.0, "monoisotopic_mass": 33619.0 }, "refseq": {}, "gene_names": [ { "name": "RGS4", "type": "recommended", "evidence": [ { "id": "A0AAA9SUK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5" } ] } ], "protein_names": [ { "name": "Regulator of G-protein signaling 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SUK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5#function" }, { "database": "UniProtKB", "id": "ARBA00025480", "url": "https://www.uniprot.org/uniprotkb/ARBA00025480#function" }, { "database": "UniProtKB", "id": "A0AAF6ZQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ80#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5", "locus": { "chromosome": "3", "start_pos": 6291077, "end_pos": 6298331, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046277", "url": "https://www.ensembl.org/id/ENSBTAG00000046277" } ] } } ], "crossref": [ { "id": "A0AAA9SUK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08714", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08714", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10845:SF184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10845:SF184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQ80", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZQ80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZQ80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGIIFLTRKRKDVKCQPQKDGEPEGGRGAGITDLLSDWLDGRGWAIKETPTGLGGRRSEDSDSIFTGEKAKCAQNRSHSSSGSTSFLVNPTLRKMCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQRKIFNLMEKDSYRRFLKSRFYLDLVNLSSCGSEKQKGAKSSTDCASLVPQCA", "length": 300, "header": "tr|A0AAA9SUK5-1|A0AAA9SUK5_BOVIN Isoform 1 of Regulator of G-protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=4 SV=1 CANONICAL=A0AAA9SUK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5/entry#A0AAA9SUK5-1", "sequence": { "sequence": "MDGIIFLTRKRKDVKCQPQKDGEPEGGRGAGITDLLSDWLDGRGWAIKETPTGLGGRRSEDSDSIFTGEKAKCAQNRSHSSSGSTSFLVNPTLRKMCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQRKIFNLMEKDSYRRFLKSRFYLDLVNLSSCGSEKQKGAKSSTDCASLVPQCA", "length": 300, "header": "tr|A0AAA9SUK5-1|A0AAA9SUK5_BOVIN Isoform 1 of Regulator of G-protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=4 SV=1 CANONICAL=A0AAA9SUK5-1" }, "locus": { "chromosome": "3", "start_pos": 6298331, "end_pos": 6293070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091062.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091062.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090138.1" } ] } }, { "isoform_ac": "A0AAA9T8U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5/entry#A0AAA9T8U0-1", "sequence": { "sequence": "MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECKPGLLHQGGDKPEHAGAHNNLLR", "length": 94, "header": "tr|A0AAA9T8U0-1|A0AAA9T8U0_BOVIN Computationally mapped isoform of Regulator of G protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=4 SV=1 CANONICAL=A0AAA9SUK5-1" }, "locus": { "chromosome": "3", "start_pos": 6297784, "end_pos": 6293236, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129314.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129314.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093252.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093252.1" } ] } }, { "isoform_ac": "A0AAA9TAE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5/entry#A0AAA9TAE9-1", "sequence": { "sequence": "MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAK", "length": 112, "header": "tr|A0AAA9TAE9-1|A0AAA9TAE9_BOVIN Computationally mapped isoform of Regulator of G protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=4 SV=1 CANONICAL=A0AAA9SUK5-1" }, "locus": { "chromosome": "3", "start_pos": 6297784, "end_pos": 6293006, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123029.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123029.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093850.1" } ] } }, { "isoform_ac": "A0AAF6ZQ80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5/entry#A0AAF6ZQ80-1", "sequence": { "sequence": "TDYMKHRLGFLLQKSDSCEHNSSHSKKDKVVICQRVSHEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQRKIFNLMEKDSYRRFLKSRFYLDLVNLSSCGSEKQKGAKSSTDCASLVPQCA", "length": 190, "header": "tr|A0AAF6ZQ80-1|A0AAF6ZQ80_BOVIN Computationally mapped isoform of Regulator of G-protein signaling 4 OS=Bos taurus OX=9913 GN=RGS4 PE=4 SV=1 CANONICAL=A0AAA9SUK5-1" }, "locus": { "chromosome": "3", "start_pos": 6294967, "end_pos": 6293070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065520.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065520.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055609.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055609.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of signal transduction", "id": "GO:0009968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUK5" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 157, "end_pos": 273, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 274, "end_pos": 276 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUL2-1", "uniprot_ac": "A0AAA9SUL2", "uniprot_id": "A0AAA9SUL2_BOVIN", "mass": { "chemical_mass": 42557.0, "monoisotopic_mass": 42557.0 }, "refseq": {}, "gene_names": [ { "name": "LOC786820", "type": "recommended", "evidence": [ { "id": "A0AAA9SUL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2" } ] } ], "protein_names": [ { "name": "MAGE domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SUL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC786820", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2", "locus": {} } ], "crossref": [ { "id": "IPR002190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11736:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11736:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPHGQKSKHCAREKRHQARAETQGLHDQATTSRGEETTSSSPPDSESTPSSWSAAGTATEPQGAQGTTSAAAGAICKRSGVGGIARSRSAVPGTACARSGVVAEGQVQEGENSSQASAAAASSHRDLLTRKAEILVQYMLFKYKMRELIKRSEMLQEINRRYKEQFPEILSRASERMELVFGLVLKEVRPNSHCYTLVSHLDLSASESMRGDRGLPKNGLLMPLLGVIYLNGNHAPEEKIWKFLNMLGIYDGRSHFIFGEPRKLITEDLVREEYLEYRQVPGSDPPRYEFLCGPKALTETGKMKVLQFLAKVKDSVHPALQPQYEEAWREEVESTGARGAARAGTSASTRPGTAASASAGTSATVRPGTAASASAGPSASATARPRAASSRSSRP", "length": 395, "header": "tr|A0AAA9SUL2-1|A0AAA9SUL2_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC786820 PE=4 SV=1 CANONICAL=A0AAA9SUL2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2/entry#A0AAA9SUL2-1", "sequence": { "sequence": "MPHGQKSKHCAREKRHQARAETQGLHDQATTSRGEETTSSSPPDSESTPSSWSAAGTATEPQGAQGTTSAAAGAICKRSGVGGIARSRSAVPGTACARSGVVAEGQVQEGENSSQASAAAASSHRDLLTRKAEILVQYMLFKYKMRELIKRSEMLQEINRRYKEQFPEILSRASERMELVFGLVLKEVRPNSHCYTLVSHLDLSASESMRGDRGLPKNGLLMPLLGVIYLNGNHAPEEKIWKFLNMLGIYDGRSHFIFGEPRKLITEDLVREEYLEYRQVPGSDPPRYEFLCGPKALTETGKMKVLQFLAKVKDSVHPALQPQYEEAWREEVESTGARGAARAGTSASTRPGTAASASAGTSATVRPGTAASASAGPSASATARPRAASSRSSRP", "length": 395, "header": "tr|A0AAA9SUL2-1|A0AAA9SUL2_BOVIN Isoform 1 of MAGE domain-containing protein OS=Bos taurus OX=9913 GN=LOC786820 PE=4 SV=1 CANONICAL=A0AAA9SUL2-1" }, "locus": { "chromosome": "NKLS02001410.1", "start_pos": 107015, "end_pos": 105831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141892.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141892.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103996.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103996.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUL2" }, { "id": "PS50838", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50838" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAGE", "eco_id": "ECO_0000259", "start_pos": 128, "end_pos": 327, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUM1-1", "uniprot_ac": "A0AAA9SUM1", "uniprot_id": "A0AAA9SUM1_BOVIN", "mass": { "chemical_mass": 2945.0, "monoisotopic_mass": 2945.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SUM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SUM1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SUM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "QQTSGSKMIFGKGTQLTVQLGKWRKH", "length": 26, "header": "tr|A0AAA9SUM1-1|A0AAA9SUM1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SUM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUM1/entry#A0AAA9SUM1-1", "sequence": { "sequence": "QQTSGSKMIFGKGTQLTVQLGKWRKH", "length": 26, "header": "tr|A0AAA9SUM1-1|A0AAA9SUM1_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SUM1-1" }, "locus": { "chromosome": "10", "start_pos": 22336666, "end_pos": 22336589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086852.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUN8-1", "uniprot_ac": "A0AAA9SUN8", "uniprot_id": "A0AAA9SUN8_BOVIN", "mass": { "chemical_mass": 47030.0, "monoisotopic_mass": 47030.0 }, "refseq": { "ac": "XP_024834492", "name": "zinc finger protein 260 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834492" }, "gene_names": [ { "name": "ZNF260", "type": "recommended", "evidence": [ { "id": "A0AAA9SUN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ] }, { "name": "ZNF260", "type": "synonym", "evidence": [ { "id": "XP_024834492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834492" } ] } ], "protein_names": [ { "name": "Zinc finger protein 260", "type": "recommended", "evidence": [ { "id": "A0AAA9SUN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8/entry#names_and_taxonomy" } ] }, { "name": "Only zinc finger protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SUN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 146", "type": "synonym", "evidence": [ { "id": "A0AAA9SUN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein OZF", "type": "synonym", "evidence": [ { "id": "A0AAA9SUN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 260 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024834492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834492" } ] } ], "function": [ { "annotation": "Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8#function" }, { "database": "UniProtKB", "id": "ARBA00053488", "url": "https://www.uniprot.org/uniprotkb/ARBA00053488#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF260", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8", "locus": { "chromosome": "18", "start_pos": 47039000, "end_pos": 47020773, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060491", "url": "https://www.ensembl.org/id/ENSBTAG00000060491" } ] } } ], "crossref": [ { "id": "112442192", "url": "https://www.ncbi.nlm.nih.gov/gene/112442192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834492", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834492", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIRMLESLRPESDLLQCDQIHTEEKLYECNECGKTFSLKQNLTEHKKMHTAEKSHECTECGKVFSRVSSLTLHLRSHTGKKSYQCNKCGKAFSQKGNLLTHQKHHTGEKPYECGKASIQMSSLIKQQRNTGNKPYACKECGKAFSGKSYLSEHEKIHTGEKPFECNQCGRAFSQKQYLVKHQNIHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYICKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKICGKAFCQSSSLTVHMRSHTGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCNECGKAFSQKSHHIRHQRIHIH", "length": 411, "header": "tr|A0AAA9SUN8-1|A0AAA9SUN8_BOVIN Isoform 1 of Zinc finger protein 260 OS=Bos taurus OX=9913 GN=ZNF260 PE=3 SV=1 CANONICAL=A0AAA9SUN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8/entry#A0AAA9SUN8-1", "sequence": { "sequence": "MIRMLESLRPESDLLQCDQIHTEEKLYECNECGKTFSLKQNLTEHKKMHTAEKSHECTECGKVFSRVSSLTLHLRSHTGKKSYQCNKCGKAFSQKGNLLTHQKHHTGEKPYECGKASIQMSSLIKQQRNTGNKPYACKECGKAFSGKSYLSEHEKIHTGEKPFECNQCGRAFSQKQYLVKHQNIHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYICKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKICGKAFCQSSSLTVHMRSHTGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCNECGKAFSQKSHHIRHQRIHIH", "length": 411, "header": "tr|A0AAA9SUN8-1|A0AAA9SUN8_BOVIN Isoform 1 of Zinc finger protein 260 OS=Bos taurus OX=9913 GN=ZNF260 PE=3 SV=1 CANONICAL=A0AAA9SUN8-1" }, "locus": { "chromosome": "18", "start_pos": 47033533, "end_pos": 47032301, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090861.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090861.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089064.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 54, "start_aa": "Tyr", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 41, "end_pos": 43 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUP5-1", "uniprot_ac": "A0AAA9SUP5", "uniprot_id": "A0AAA9SUP5_BOVIN", "mass": { "chemical_mass": 34980.0, "monoisotopic_mass": 34980.0 }, "refseq": { "ac": "NP_001377542", "name": "olfactory receptor family 4 subfamily A member 47R", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377542" }, "gene_names": [ { "name": "OR4A47R", "type": "recommended", "evidence": [ { "id": "A0AAA9SUP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5" } ] }, { "name": "OR4A47R", "type": "synonym", "evidence": [ { "id": "NP_001377542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377542" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SUP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 4 subfamily A member 47R", "type": "synonym", "evidence": [ { "id": "NP_001377542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377542" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377542" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4A47R", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5", "locus": { "chromosome": "15", "start_pos": 78259858, "end_pos": 78199298, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060197", "url": "https://www.ensembl.org/id/ENSBTAG00000060197" } ] } } ], "crossref": [ { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789193", "url": "https://www.ncbi.nlm.nih.gov/gene/789193", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789193", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789193", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:789201", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789201", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTDTHAI", "url": "https://omabrowser.org/oma/group/CTDTHAI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377542", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESRNNVTYFVLLGLTQNPKEQKVLSVLFLFIYLLTLVGNLLIIVTIAVSETLNSPMYFFLASLSCMDVTYSTSITPRLISELLFGEKYISFESCMTQLFAEHLFAGSGVFLLLVMAYDRYVAICKPLHYLVIMRQRVCVVLLVVSWVGGFLHSVIQLSTIYWLPFCGPNVIDHYMCDMYPLLELICTDTYVTGILVLANGGLICTIVFLLLLISYGVILHSLKNLSQEGRRKALQTCGSHITVVVCFFVPCIFINARPAKTFPIDKLLSVLYTVISPMLNPLIYSLRNSELTNAMKKLWRRNIISHIK", "length": 309, "header": "tr|A0AAA9SUP5-1|A0AAA9SUP5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A47R PE=3 SV=2 CANONICAL=A0AAA9SUP5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5/entry#A0AAA9SUP5-1", "sequence": { "sequence": "MESRNNVTYFVLLGLTQNPKEQKVLSVLFLFIYLLTLVGNLLIIVTIAVSETLNSPMYFFLASLSCMDVTYSTSITPRLISELLFGEKYISFESCMTQLFAEHLFAGSGVFLLLVMAYDRYVAICKPLHYLVIMRQRVCVVLLVVSWVGGFLHSVIQLSTIYWLPFCGPNVIDHYMCDMYPLLELICTDTYVTGILVLANGGLICTIVFLLLLISYGVILHSLKNLSQEGRRKALQTCGSHITVVVCFFVPCIFINARPAKTFPIDKLLSVLYTVISPMLNPLIYSLRNSELTNAMKKLWRRNIISHIK", "length": 309, "header": "tr|A0AAA9SUP5-1|A0AAA9SUP5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4A47R PE=3 SV=2 CANONICAL=A0AAA9SUP5-1" }, "locus": { "chromosome": "15", "start_pos": 78258942, "end_pos": 78258016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104406.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104406.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088919.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789193", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789193", "resource": "KEGG Pathway" }, { "id": "bta:789201", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789201", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 285, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUQ0-1", "uniprot_ac": "A0AAA9SUQ0", "uniprot_id": "A0AAA9SUQ0_BOVIN", "mass": { "chemical_mass": 63405.0, "monoisotopic_mass": 63405.0 }, "refseq": { "ac": "XP_024839078", "name": "synapsin-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839078" }, "gene_names": [ { "name": "SYN2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ] }, { "name": "SYN2", "type": "synonym", "evidence": [ { "id": "XP_024839078", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839078" } ] } ], "protein_names": [ { "name": "Synapsin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9SUQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0/entry#names_and_taxonomy" } ] }, { "name": "Synapsin II", "type": "synonym", "evidence": [ { "id": "A0AAA9SUQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0/entry#names_and_taxonomy" } ] }, { "name": "synapsin-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839078", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839078" } ] } ], "function": [ { "annotation": "Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0#function" }, { "database": "UniProtKB", "id": "ARBA00056023", "url": "https://www.uniprot.org/uniprotkb/ARBA00056023#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0", "locus": { "chromosome": "22", "start_pos": 56883343, "end_pos": 57072552, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020260", "url": "https://www.ensembl.org/id/ENSBTAG00000020260" } ] } } ], "crossref": [ { "id": "A0AAA9SUQ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "782758", "url": "https://www.ncbi.nlm.nih.gov/gene/782758", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782758", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782758", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10841", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10841", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10841:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10841:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02078", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02078", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02750", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02750", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839078", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839078", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPGPGAASASSAPPAASPGPERRPPPAQAPAPQPAPQPTPAPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGTNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVVSKMNQLLSRTPILSPQRPLTTQQPQSGTLKDPDSSKTPPQRPAPQGGPGQPQGMQPPGKVLPPRRLPPGPSVPPSSSSSSSSSSSSSAPPRPGGPTTHGDAPSSSSSLAEAQPPPAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSASEDEAKAETIRSLRKSFASLFSD", "length": 587, "header": "tr|A0AAA9SUQ0-1|A0AAA9SUQ0_BOVIN Isoform 1 of Synapsin-2 OS=Bos taurus OX=9913 GN=SYN2 PE=3 SV=1 CANONICAL=A0AAA9SUQ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0/entry#A0AAA9SUQ0-1", "sequence": { "sequence": "MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPGPGAASASSAPPAASPGPERRPPPAQAPAPQPAPQPTPAPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGTNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVVSKMNQLLSRTPILSPQRPLTTQQPQSGTLKDPDSSKTPPQRPAPQGGPGQPQGMQPPGKVLPPRRLPPGPSVPPSSSSSSSSSSSSSAPPRPGGPTTHGDAPSSSSSLAEAQPPPAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSASEDEAKAETIRSLRKSFASLFSD", "length": 587, "header": "tr|A0AAA9SUQ0-1|A0AAA9SUQ0_BOVIN Isoform 1 of Synapsin-2 OS=Bos taurus OX=9913 GN=SYN2 PE=3 SV=1 CANONICAL=A0AAA9SUQ0-1" }, "locus": { "chromosome": "22", "start_pos": 57072356, "end_pos": 56915105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111122.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111122.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087695.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 76, "start_aa": "Thr", "end_pos": 76, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr76", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:782758", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782758", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "synaptic vesicle clustering", "id": "GO:0097091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "neurotransmitter secretion", "id": "GO:0007269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007269", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "calcium-ion regulated exocytosis", "id": "GO:0017156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" }, { "id": "PF02750", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02750" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Synapsin ATP-binding", "eco_id": "ECO_0000259", "start_pos": 217, "end_pos": 419, "start_aa": "Asn", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SUQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUQ0" }, { "id": "PF02078", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02078" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Synapsin pre-ATP-grasp", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 215, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 76 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 543, "end_pos": 545 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUV9-1", "uniprot_ac": "A0AAA9SUV9", "uniprot_id": "A0AAA9SUV9_BOVIN", "mass": { "chemical_mass": 23291.0, "monoisotopic_mass": 23291.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SUV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SUV9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR027943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR35157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35157:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35157:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15206", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15206", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTEKTITLTRRTIVGILMSLLFNMLSTLVIAFLPRSKHLLISRLQSHPRPRDEAEELPWIVPSGRHFRVRQNQPEHVPGWFGSKSHWLLIFLMFLVILKFPGGDDKSIAGTPPGRQGCSSGSPGRKKIRASPYKDSMCGALTQVETTLVNLVSRVRSLKLTAATGDQRQCPNIQVLADGWNNITIYEIWDTRAPDEVDFRIKEEE", "length": 206, "header": "tr|A0AAA9SUV9-1|A0AAA9SUV9_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SUV9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV9/entry#A0AAA9SUV9-1", "sequence": { "sequence": "MTTEKTITLTRRTIVGILMSLLFNMLSTLVIAFLPRSKHLLISRLQSHPRPRDEAEELPWIVPSGRHFRVRQNQPEHVPGWFGSKSHWLLIFLMFLVILKFPGGDDKSIAGTPPGRQGCSSGSPGRKKIRASPYKDSMCGALTQVETTLVNLVSRVRSLKLTAATGDQRQCPNIQVLADGWNNITIYEIWDTRAPDEVDFRIKEEE", "length": 206, "header": "tr|A0AAA9SUV9-1|A0AAA9SUV9_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SUV9-1" }, "locus": { "chromosome": "NKLS02000510.1", "start_pos": 38549, "end_pos": 32512, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117396.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117396.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087753.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087753.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUW0-1", "uniprot_ac": "A0AAA9SUW0", "uniprot_id": "A0AAA9SUW0_BOVIN", "mass": { "chemical_mass": 92044.0, "monoisotopic_mass": 92044.0 }, "refseq": {}, "gene_names": [ { "name": "OSBPL11", "type": "recommended", "evidence": [ { "id": "A0AAA9SUW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ] } ], "protein_names": [ { "name": "Oxysterol-binding protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SUW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex.", "evidence": [ { "database": "UniProtKB", "id": "E1BJC1", "url": "https://www.uniprot.org/uniprotkb/E1BJC1#function" }, { "database": "UniProtKB", "id": "ARBA00058048", "url": "https://www.uniprot.org/uniprotkb/ARBA00058048#function" }, { "database": "UniProtKB", "id": "A0AAA9TLB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OSBPL11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0", "locus": { "chromosome": "1", "start_pos": 69962335, "end_pos": 70053215, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006471", "url": "https://www.ensembl.org/id/ENSBTAG00000006471" } ] } } ], "crossref": [ { "id": "A0AAA9SUW0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006471", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006471", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13291", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13291", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJC1", "url": "https://www.orthodb.org/?gene=E1BJC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10972:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013407", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013407", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "81667", "url": "https://www.rhea-db.org/rhea/81667", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJC1", "url": "https://www.uniprot.org/uniprotkb/E1BJC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BJC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFGVKMQGGEPVSAMKVSESEGRLEGLATAVTPNKNSSNSSCGGGISSSSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNTISFFNVGHSRLQSVSKRANLPPDHLVEVREMMSHAEGQQRDLIRGIECLPASGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKIPLSNHYKNGADQPFATEQSKPVAVPEEQCVAESGLLAREPEEINADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVASSVINSSSTQAITNHVPPSEEALNQMGSDCYTVRFVAEQVSHHPPVSGFYAECAERKICVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVNVNCAKTGYSASITFHTKPFYGGKLHRQQPIRLPRPWDSPGKNTGVGCHFLLQCMQVKSESEVAHSVVSNSLRPHGLQPTAWMENLLSMGFSRVTGEVKHNITNTVVCRVQGEWNSVLEFAYSSGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRDSEIDKATEHKRTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKIIPTTQPAE", "length": 824, "header": "tr|A0AAA9SUW0-1|A0AAA9SUW0_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL11 PE=3 SV=1 CANONICAL=A0AAA9SUW0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0/entry#A0AAA9SUW0-1", "sequence": { "sequence": "MDFGVKMQGGEPVSAMKVSESEGRLEGLATAVTPNKNSSNSSCGGGISSSSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNTISFFNVGHSRLQSVSKRANLPPDHLVEVREMMSHAEGQQRDLIRGIECLPASGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKIPLSNHYKNGADQPFATEQSKPVAVPEEQCVAESGLLAREPEEINADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVASSVINSSSTQAITNHVPPSEEALNQMGSDCYTVRFVAEQVSHHPPVSGFYAECAERKICVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVNVNCAKTGYSASITFHTKPFYGGKLHRQQPIRLPRPWDSPGKNTGVGCHFLLQCMQVKSESEVAHSVVSNSLRPHGLQPTAWMENLLSMGFSRVTGEVKHNITNTVVCRVQGEWNSVLEFAYSSGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRDSEIDKATEHKRTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKIIPTTQPAE", "length": 824, "header": "tr|A0AAA9SUW0-1|A0AAA9SUW0_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL11 PE=3 SV=1 CANONICAL=A0AAA9SUW0-1" }, "locus": { "chromosome": "1", "start_pos": 70052736, "end_pos": 69963261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087955.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087955.1" } ] } }, { "isoform_ac": "A0AAA9TLB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0/entry#A0AAA9TLB3-1", "sequence": { "sequence": "MPPSPLAGVVSPAQEGQMDFGVKMQGGEPVSAMKVSESEGRLEGLATAVTPNKNSSNSSCGGGISSSSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNTISFFNVGHSRLQSVSKRANLPPDHLVEVREMMSHAEGQQRDLIRGIECLPASGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKIPLSNHYKNGADQPFATEQSKPVAVPEEQCVAESGLLAREPEEINADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVASSVINSSSTQAITNHVPPSEEALNQMGSDCYTVRFVAEQVSHHPPVSGFYAECAERKICVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVNVNCAKTGYSASITFHTKPFYGGKLHRVTGEVKHNITNTVVCRVQGEWNSVLEFAYSSGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRDSEIDKATEHKRTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKIIPTTQPAE", "length": 775, "header": "tr|A0AAA9TLB3-1|A0AAA9TLB3_BOVIN Computationally mapped isoform of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL11 PE=3 SV=1 CANONICAL=A0AAA9SUW0-1" }, "locus": { "chromosome": "1", "start_pos": 70053016, "end_pos": 69963261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124886.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124886.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099224.1" } ] } }, { "isoform_ac": "E1BJC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0/entry#E1BJC1-1", "sequence": { "sequence": "MNCRLNDKRGTERFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNTISFFNVGHSRLQSVSKRANLPPDHLVEVREMMSHAEGQQRDLIRGIECLPASGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKIPLSNHYKNGADQPFATEQSKPVAVPEEQCVAESGLLAREPEEINADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVASSVINSSSTQAITNHVPPSEEALNQMGSDCYTVRFVAEQVSHHPPVSGFYAECAERKICVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVNVNCAKTGYSASITFHTKPFYGGKLHRVTGEVKHNITNTVVCRVQGEWNSVLEFAYSSGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRDSEIDKATEHKRTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKIIPTTQPAE", "length": 682, "header": "tr|E1BJC1-1|E1BJC1_BOVIN Computationally mapped isoform of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL11 PE=3 SV=3 CANONICAL=A0AAA9SUW0-1" }, "locus": { "chromosome": "1", "start_pos": 70023623, "end_pos": 69963261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008486.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008486.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008486.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008486.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9013407", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013407", "resource": "Reactome", "description": "RHOH GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "endoplasmic reticulum-trans-Golgi network membrane contact site", "id": "GO:0160258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160258", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "phospholipid transfer to membrane", "id": "GO:0006649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006649", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "phospholipid homeostasis", "id": "GO:0055091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "triglyceride homeostasis", "id": "GO:0070328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070328", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "lysosomal membrane organization", "id": "GO:0097212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity", "id": "GO:0160270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" }, { "name": "sterol binding", "id": "GO:0032934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032934", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" }, { "start_pos": 757, "end_pos": 759, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "81667", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "81667", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81667" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW0" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 69, "end_pos": 166, "start_aa": "Met", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 37, "end_pos": 39 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 485, "end_pos": 487 }, { "start_pos": 699, "end_pos": 701 }, { "start_pos": 757, "end_pos": 759 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV01-1", "uniprot_ac": "A0AAA9SV01", "uniprot_id": "A0AAA9SV01_BOVIN", "mass": { "chemical_mass": 79155.0, "monoisotopic_mass": 79155.0 }, "refseq": {}, "gene_names": [ { "name": "SRRM3", "type": "recommended", "evidence": [ { "id": "A0AAA9SV01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" } ] } ], "protein_names": [ { "name": "Serine/arginine repetitive matrix 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SV01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRRM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01", "locus": { "chromosome": "25", "start_pos": 34338021, "end_pos": 34284109, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007879", "url": "https://www.ensembl.org/id/ENSBTAG00000007879" } ] } } ], "crossref": [ { "id": "A0AAA9SV01", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007879", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007879", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR013170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJS4", "url": "https://www.orthodb.org/?gene=E1BJS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34755", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34755", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34755:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34755:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08312", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08312", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SV01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJS4", "url": "https://www.uniprot.org/uniprotkb/E1BJS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJS4-1", "url": "https://www.uniprot.org/uniprotkb/E1BJS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVRCPAFQQSAAAPAGRRRARGRGGRGATLPSRAEPRRRPGGHPDKRDQRAWLQHPAELSSQQEGPRPAAPGAATMSSTVNNGAASVPSPPDAANGFPQPGVSSGAWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEETRQKVRTFRQMLMEKEGMLTREDRPGGHIVAETPRLIEGAELGLEYAPFDEDDGPVDCDCPASCYRGHRGDRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLDSECSCGSSSPLRKKKKSVKKHRRDRSESGSRRKRRHRSRSPKSKRKEKNKERKRPHTESPGRRSHRHSSGSSHSPSLSSHYSNSRSPSRLSPKHRDDGRKTGSQRSSGSRSPSPSGGSGWGSPQQNGGSRQRSGAHGGRPGSAQSPLDKPSSPSPRARDQAEAGAATPPARGKESPSPRSAPSSRGRGGRAAGGAARRRRRRRRRRRSRSSASAPRRRGRRRARPAPPRGSSRSLSRARSSSDSGGGAPGPGPEPGSERGHGGHGKRAKERAPRTRPASTSPSPGRHGGPEGRSSSRSPGQHPRSWSSSRSPSKSRSRSAEKRARSPSRSPSPKKTLGRDKDGESRARHAEAEAARARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSSRSPSHSPSPGHSHGSYSSRSRTRSRTRSPSQTPTPSYHSRSSSESGGF", "length": 723, "header": "tr|A0AAA9SV01-1|A0AAA9SV01_BOVIN Isoform 1 of Serine/arginine repetitive matrix 3 OS=Bos taurus OX=9913 GN=SRRM3 PE=4 SV=1 CANONICAL=A0AAA9SV01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01/entry#A0AAA9SV01-1", "sequence": { "sequence": "MVVRCPAFQQSAAAPAGRRRARGRGGRGATLPSRAEPRRRPGGHPDKRDQRAWLQHPAELSSQQEGPRPAAPGAATMSSTVNNGAASVPSPPDAANGFPQPGVSSGAWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEETRQKVRTFRQMLMEKEGMLTREDRPGGHIVAETPRLIEGAELGLEYAPFDEDDGPVDCDCPASCYRGHRGDRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLDSECSCGSSSPLRKKKKSVKKHRRDRSESGSRRKRRHRSRSPKSKRKEKNKERKRPHTESPGRRSHRHSSGSSHSPSLSSHYSNSRSPSRLSPKHRDDGRKTGSQRSSGSRSPSPSGGSGWGSPQQNGGSRQRSGAHGGRPGSAQSPLDKPSSPSPRARDQAEAGAATPPARGKESPSPRSAPSSRGRGGRAAGGAARRRRRRRRRRRSRSSASAPRRRGRRRARPAPPRGSSRSLSRARSSSDSGGGAPGPGPEPGSERGHGGHGKRAKERAPRTRPASTSPSPGRHGGPEGRSSSRSPGQHPRSWSSSRSPSKSRSRSAEKRARSPSRSPSPKKTLGRDKDGESRARHAEAEAARARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSSRSPSHSPSPGHSHGSYSSRSRTRSRTRSPSQTPTPSYHSRSSSESGGF", "length": 723, "header": "tr|A0AAA9SV01-1|A0AAA9SV01_BOVIN Isoform 1 of Serine/arginine repetitive matrix 3 OS=Bos taurus OX=9913 GN=SRRM3 PE=4 SV=1 CANONICAL=A0AAA9SV01-1" }, "locus": { "chromosome": "25", "start_pos": 34336733, "end_pos": 34284125, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069701.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069701.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087791.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087791.1" } ] } }, { "isoform_ac": "A0AAA9SYT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01/entry#A0AAA9SYT4-1", "sequence": { "sequence": "MSSTVNNGAASVPSPPDAANGFPQPGVSSGAWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEETRQKVRTFRQMLMEKEGMLTREDRPGGHIVAETPRLIEGAELGLEYAPFDEDDGPVDCDCPASCYRGHRGDRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLDSECSCGSSSPLRKKKKSVKKHRRDRSESGSRRKRRHRSRSPKSKRKEKNKERKRPHTESPGRRSHRHSSGSSHSPSLSSHYSNSRSPSRLSPKHRDDGRKTGSQRSSGSRSPSPSGGSGWGSPQQNGGSRQRSGAHGGRPGSAQSPLDKPSSPSPRARDQAEAGAATPPARGKESPSPRSAPSSRGRGGRAAGGAARRRRRRRRRRRSRSSASAPRRRGRRRARPAPPRGSSRSLSRARSSSDSGGGAPGPGPEPGSERGHGGHGKRAKERAPRTRPASTSPSPGRHGGPEGRSSSRSPGQHPRSWSSSRSPSKSRSRSAEKRARSPSRSPSPKKTLGRDKDGESRARHAEAEAARARRRSRSYSPIRKRRRDSPSFMEPRRITRSSLLSGLWPAWGPGGPPLHRPQGRYPLPGSVPSPTTDPAPRPPPAA", "length": 619, "header": "tr|A0AAA9SYT4-1|A0AAA9SYT4_BOVIN Computationally mapped isoform of Serine/arginine repetitive matrix 3 OS=Bos taurus OX=9913 GN=SRRM3 PE=4 SV=1 CANONICAL=A0AAA9SV01-1" }, "locus": { "chromosome": "25", "start_pos": 34336569, "end_pos": 34306569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099603.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099603.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091613.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091613.1" } ] } }, { "isoform_ac": "E1BJS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01/entry#E1BJS4-1", "sequence": { "sequence": "MVVRCPAFQQSAAAPAGRRRARGRGGRGATLPSRAEPRRRPGGHPDKRDQRAWLQHPAELSSQQEGPRPAAPGAATMSSTVNNGAASVPSPPDAANGFPQPGVSSGAWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEETRQKVRTFRQMLMEKEGMLTREDRPGGHIVAETPRLIEGAELGLEYAPFDEDDGPVDCDCPASCYRGHRGDRTKHWSSSSASPPPKKKKKKKGGHRRSRKKRRLDSECSCGSSSPLRKKKKSVKKHRRDRSESGSRRKRRHRSRSPKSKRKEKNKERKRPHTESPGRRSHRHSSGSSHSPSLSSHYSNSRSPSRLSPKHRDDGRKTGSQRSSGSRSPSPSGGSGWGSPQQNGGSRQRSGAHGGRPGSAQSPLDGQGAGPAHPARQHLAVPGQARRARGEELVAQPRPAPALLELQPLALQIPLALGGEEGPQPQPLAVAQENPGSGQGRGEPREARRGRGRPRPAPLPQLLAHPQAAPGLAQLHGAAAHHQCPEASHPLLPTQPLVLLQLPEQRLLKPEPQPQPQPRPQPRKLQQPQSDPQPHTKSLPDPHSQLPQPEQLREWGLLSPGNPASCPLAQGKARAPGAMGGSGACTPLLQRGPGTGEDLEGGGCPEDKEELDSAASGGSPPHLLLTHAVQGTKSRFEHRDHHPFLLDASSPG", "length": 699, "header": "tr|E1BJS4-1|A0AAA9SV01_BOVIN Computationally mapped isoform of Serine/arginine repetitive matrix 3 OS=Bos taurus OX=9913 GN=SRRM3 PE=4 SV=4 CANONICAL=A0AAA9SV01-1" }, "locus": { "chromosome": "25", "start_pos": 34337017, "end_pos": 34284125, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053393.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053393.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048117.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048117.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 709, "start_aa": "Thr", "end_pos": 709, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr709", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of insulin secretion", "id": "GO:0046676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" } ], "pmid": "" }, { "name": "negative regulation of glucagon secretion", "id": "GO:0070093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070093", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SV01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV01" }, { "id": "SM01115", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CWF21", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 176, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 709 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV19-1", "uniprot_ac": "A0AAA9SV19", "uniprot_id": "A0AAA9SV19_BOVIN", "mass": { "chemical_mass": 72974.0, "monoisotopic_mass": 72974.0 }, "refseq": { "ac": "XP_005210536", "name": "zinc finger protein 189 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210536" }, "gene_names": [ { "name": "ZNF189", "type": "recommended", "evidence": [ { "id": "A0AAA9SV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ] }, { "name": "ZNF189", "type": "synonym", "evidence": [ { "id": "XP_005210536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210536" } ] } ], "protein_names": [ { "name": "Zinc finger protein 189", "type": "synonym", "evidence": [ { "id": "A0AAA9SV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 189 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005210536", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210536" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "F6RK19", "url": "https://www.uniprot.org/uniprotkb/F6RK19#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF189", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19", "locus": { "chromosome": "8", "start_pos": 91132043, "end_pos": 91120607, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015348", "url": "https://www.ensembl.org/id/ENSBTAG00000015348" } ] } } ], "crossref": [ { "id": "A0AAA9SV19", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015348", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015348", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540816", "url": "https://www.ncbi.nlm.nih.gov/gene/540816", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F6RK19", "url": "https://www.orthodb.org/?gene=F6RK19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24393:SF106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24393:SF106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005210536", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210536", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RK19", "url": "https://www.uniprot.org/uniprotkb/F6RK19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RK19-1", "url": "https://www.uniprot.org/uniprotkb/F6RK19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPSPPPQPKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLDVLNRDKDEEPTVKQEIEEIEEEMEPQGIIVTRIKSEIDQDPMHRETFELVGRLDKQRGIFLWEIPRESLTQEQRMFRGNTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNHCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYSYNETKESFDPNGGLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKIQETHECDACGEAFNCRISLIQHQKLHATWMQ", "length": 626, "header": "tr|A0AAA9SV19-1|A0AAA9SV19_BOVIN Isoform 1 of Zinc finger protein 189 OS=Bos taurus OX=9913 GN=ZNF189 PE=3 SV=1 CANONICAL=A0AAA9SV19-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19/entry#A0AAA9SV19-1", "sequence": { "sequence": "MASPSPPPQPKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLDVLNRDKDEEPTVKQEIEEIEEEMEPQGIIVTRIKSEIDQDPMHRETFELVGRLDKQRGIFLWEIPRESLTQEQRMFRGNTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNHCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYSYNETKESFDPNGGLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKIQETHECDACGEAFNCRISLIQHQKLHATWMQ", "length": 626, "header": "tr|A0AAA9SV19-1|A0AAA9SV19_BOVIN Isoform 1 of Zinc finger protein 189 OS=Bos taurus OX=9913 GN=ZNF189 PE=3 SV=1 CANONICAL=A0AAA9SV19-1" }, "locus": { "chromosome": "8", "start_pos": 91131039, "end_pos": 91120806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096669.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096669.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090316.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090316.1" } ] } }, { "isoform_ac": "F6RK19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19/entry#F6RK19-1", "sequence": { "sequence": "MGTYSTSMADVLNRDKDEEPTVKQEIEEIEEEMEPQGIIVTRIKSEIDQDPMHRETFELVGRLDKQRGIFLWEIPRESLTQEQRMFRGNTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNHCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYSYNETKESFDPNGGLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKIQETHECDACGEAFNCRISLIQHQKLHATWMQ", "length": 582, "header": "tr|F6RK19-1|F6RK19_BOVIN Computationally mapped isoform of Zinc finger protein 189 OS=Bos taurus OX=9913 GN=ZNF189 PE=3 SV=3 CANONICAL=A0AAA9SV19-1" }, "locus": { "chromosome": "8", "start_pos": 91131039, "end_pos": 91125373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020403.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020403.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020403.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020403.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" }, { "name": "positive regulation of biosynthetic process", "id": "GO:0009891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 148, "end_pos": 175, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV19" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 89, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 386, "end_pos": 388 }, { "start_pos": 431, "end_pos": 433 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV49-1", "uniprot_ac": "A0AAA9SV49", "uniprot_id": "A0AAA9SV49_BOVIN", "mass": { "chemical_mass": 26463.0, "monoisotopic_mass": 26463.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Transcription factor Spi-C", "type": "recommended", "evidence": [ { "id": "A0AAA9SV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49#function" }, { "database": "UniProtKB", "id": "ARBA00055710", "url": "https://www.uniprot.org/uniprotkb/ARBA00055710#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49", "locus": {} } ], "crossref": [ { "id": "A0AAA9SV49", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV49", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACAEQDKLGQAFEDSFEVLRQHSTGDFQYSSDYKNYLAFINHRSHIRGNSNSYGLQPAEEPIYNWRTVTNSATDLYFEGNIHQSLQNIPKNQLVQPALLQQKGGKEMASCIQWIDQTKGIFQFVSKNKEKLAQLWGKRKGNQKTMTYQKMARALRNYGRTGEIIKIRRKLTYQFSEAVLQRLSAPYFLEKEIFYSQYVQPDQGYLSLNNWNANYNYTYANYHDID", "length": 226, "header": "tr|A0AAA9SV49-1|A0AAA9SV49_BOVIN Isoform 1 of Transcription factor Spi-C OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SV49-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49/entry#A0AAA9SV49-1", "sequence": { "sequence": "MACAEQDKLGQAFEDSFEVLRQHSTGDFQYSSDYKNYLAFINHRSHIRGNSNSYGLQPAEEPIYNWRTVTNSATDLYFEGNIHQSLQNIPKNQLVQPALLQQKGGKEMASCIQWIDQTKGIFQFVSKNKEKLAQLWGKRKGNQKTMTYQKMARALRNYGRTGEIIKIRRKLTYQFSEAVLQRLSAPYFLEKEIFYSQYVQPDQGYLSLNNWNANYNYTYANYHDID", "length": 226, "header": "tr|A0AAA9SV49-1|A0AAA9SV49_BOVIN Isoform 1 of Transcription factor Spi-C OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SV49-1" }, "locus": { "chromosome": "X", "start_pos": 86573772, "end_pos": 86572828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082631.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082631.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087061.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV49" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 93, "end_pos": 176, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 216, "end_pos": 218 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV53-1", "uniprot_ac": "A0AAA9SV53", "uniprot_id": "A0AAA9SV53_BOVIN", "mass": { "chemical_mass": 17491.0, "monoisotopic_mass": 17491.0 }, "refseq": { "ac": "NP_001193131", "name": "protein FAM163B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193131" }, "gene_names": [ { "name": "FAM163B", "type": "recommended", "evidence": [ { "id": "A0AAA9SV53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53" } ] }, { "name": "FAM163B", "type": "synonym", "evidence": [ { "id": "NP_001193131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193131" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 163 member B", "type": "synonym", "evidence": [ { "id": "A0AAA9SV53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53/entry#names_and_taxonomy" } ] }, { "name": "protein FAM163B", "type": "synonym", "evidence": [ { "id": "NP_001193131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193131" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM163B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53", "locus": { "chromosome": "11", "start_pos": 104452896, "end_pos": 104480720, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062677", "url": "https://www.ensembl.org/id/ENSBTAG00000062677" } ] } } ], "crossref": [ { "id": "A0AAA9SV53", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV53", "database": "AlphaFoldDB", "categories": [] }, { "id": "615192", "url": "https://www.ncbi.nlm.nih.gov/gene/615192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615192", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615192", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DFAVHAH", "url": "https://omabrowser.org/oma/group/DFAVHAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31396", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31396", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31396:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31396:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193131", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SV53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSRLPPLHSNRNLVLSNGPALCPAAAFSQRSPQARALCRSCSRSEPPAFFLQEPEDEGVSNGGERVAYRSISQEDVGPPPGGFGGLQALNPNRLSAMREAFSRSRSVSTDV", "length": 162, "header": "tr|A0AAA9SV53-1|A0AAA9SV53_BOVIN Isoform 1 of Family with sequence similarity 163 member B OS=Bos taurus OX=9913 GN=FAM163B PE=3 SV=1 CANONICAL=A0AAA9SV53-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53/entry#A0AAA9SV53-1", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSRLPPLHSNRNLVLSNGPALCPAAAFSQRSPQARALCRSCSRSEPPAFFLQEPEDEGVSNGGERVAYRSISQEDVGPPPGGFGGLQALNPNRLSAMREAFSRSRSVSTDV", "length": 162, "header": "tr|A0AAA9SV53-1|A0AAA9SV53_BOVIN Isoform 1 of Family with sequence similarity 163 member B OS=Bos taurus OX=9913 GN=FAM163B PE=3 SV=1 CANONICAL=A0AAA9SV53-1" }, "locus": { "chromosome": "11", "start_pos": 104454253, "end_pos": 104452936, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130220.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130220.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087067.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087067.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615192", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615192", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z988-1", "protein_name": "Family with sequence similarity 163, member B", "gene_name": "Fam163b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSHLPPLHSNRNLVLTNGPALYPAATTSFSQKSPQARALCRSCSHYEPPTFFLQEPEDDDFEGVRNGGGRVAYKSISQEDVELPSASFGGLQALNPNRLSAMREAFSRSRSALPWSSRRSKCPHEGAFL", "length": 180 }, "evidence": [ { "id": "A0AAA9SV53", "url": "https://omabrowser.org/oma/group/A0AAA9SV53/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LTY4-1", "protein_name": "Family with sequence similarity 163 member B", "gene_name": "FAM163B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHAHVPPLHSNRNLVLTNGPALYPAASTSFSQKSPQARTLCRSCSHYEPPTFFLQEPEDEGVRNGGERVAYRSISQEDVELGPPGSFGALQALNPNRLSAMREAFSRSRSISTDV", "length": 165 }, "evidence": [ { "id": "A0AAA9SV53", "url": "https://omabrowser.org/oma/group/A0AAA9SV53/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P0C2L3-1", "protein_name": "Protein FAM163B", "gene_name": "FAM163B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSHLPPLHSNRNLVLTNGPALYPTASTSFSQKSPQARALCRSCSHCEPPTFFLQEPPEEEEDVLNGGERVLYKSVSQEDVELPPGGFGGLQALNPNRLSAMREAFARSRSISTDV", "length": 166 }, "evidence": [ { "id": "A0AAA9SV53", "url": "https://omabrowser.org/oma/group/A0AAA9SV53/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BUM6-1", "protein_name": "Protein FAM163B", "gene_name": "Fam163b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSHLPPLHSNRNLVLTNGPALYPAATTSFSQKSPQARALCRSCSHYEPPTFFLQEPEDEDFEGVRNGGGRVAYKSISQEDVELPSASFGGLQALNPNRLSAMREAFSRSRSVSTDV", "length": 167 }, "evidence": [ { "id": "A0AAA9SV53", "url": "https://omabrowser.org/oma/group/A0AAA9SV53/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "R4GL56-1", "protein_name": "Family with sequence similarity 163 member B", "gene_name": "FAM163B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKDESEEDEEEPDFAVHSHIPPLHCNRNVVLTNGPSLYSSSPFSKKATPSRSGCPGCGQYEPPTFFLQEPPEELHNGGDRVSFQTVSQEELDLPVSVGNLQALNPNRLSAMREAFSRSRSISTDV", "length": 160 }, "evidence": [ { "id": "A0AAA9SV53", "url": "https://omabrowser.org/oma/group/A0AAA9SV53/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV75-1", "uniprot_ac": "A0AAA9SV75", "uniprot_id": "A0AAA9SV75_BOVIN", "mass": { "chemical_mass": 10212.0, "monoisotopic_mass": 10212.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SV75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75", "locus": {} } ], "crossref": [ { "id": "A0AAA9SV75", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV75", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19339:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19339:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SV75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ELKVEQSPPSLIIQEGPTGINFDHSFTTSDTFLWYRQDQGKSLESLFLLMSNRTVRKKGGLTASFDIKAHGSPLHITASHPGLSATYFCAVDA", "length": 93, "header": "tr|A0AAA9SV75-1|A0AAA9SV75_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SV75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75/entry#A0AAA9SV75-1", "sequence": { "sequence": "ELKVEQSPPSLIIQEGPTGINFDHSFTTSDTFLWYRQDQGKSLESLFLLMSNRTVRKKGGLTASFDIKAHGSPLHITASHPGLSATYFCAVDA", "length": 93, "header": "tr|A0AAA9SV75-1|A0AAA9SV75_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SV75-1" }, "locus": { "chromosome": "10", "start_pos": 22633580, "end_pos": 22633302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090369.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090369.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SV78-1", "uniprot_ac": "A0AAA9SV78", "uniprot_id": "A0AAA9SV78_BOVIN", "mass": { "chemical_mass": 83664.0, "monoisotopic_mass": 83664.0 }, "refseq": { "ac": "XP_002688406", "name": "ankyrin repeat domain-containing protein SOWAHB", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688406" }, "gene_names": [ { "name": "SOWAHB", "type": "recommended", "evidence": [ { "id": "A0AAA9SV78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78" } ] }, { "name": "SOWAHB", "type": "synonym", "evidence": [ { "id": "XP_002688406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688406" } ] } ], "protein_names": [ { "name": "Sosondowah ankyrin repeat domain family member B", "type": "synonym", "evidence": [ { "id": "A0AAA9SV78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat domain-containing protein SOWAHB", "type": "synonym", "evidence": [ { "id": "XP_002688406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688406" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SV78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SOWAHB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78", "locus": { "chromosome": "6", "start_pos": 91717591, "end_pos": 91743304, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038148", "url": "https://www.ensembl.org/id/ENSBTAG00000038148" } ] } } ], "crossref": [ { "id": "A0AAA9SV78", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SV78", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038148", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038148", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512359", "url": "https://www.ncbi.nlm.nih.gov/gene/512359", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512359", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512359", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WECLQNG", "url": "https://omabrowser.org/oma/group/WECLQNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCD1", "url": "https://www.orthodb.org/?gene=F1MCD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14491", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14491", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14491:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14491:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25877", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25877", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688406", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688406", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SV78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCD1", "url": "https://www.uniprot.org/uniprotkb/F1MCD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCD1-1", "url": "https://www.uniprot.org/uniprotkb/F1MCD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDAPPSQQQRRRELFKGYVNSVAAVRQDPDGTKYVVLKRRYRDLVGEEEGLRRPRDPPAGAAPAGGAAPGSPLPERRGEHPPQPQPGRRIRREEAPAGAAAPVADAGCNGLPAGGAREAARGGGRPRGRSGHRAPVPAAAVAAAAQDRARCAAAETQGRCCWECLQNGLGGLPDPATASASAAEKLAQDDRGAPRPQWEGVLAEPPPGPATPRSPPATVEAAAPPAVLSSPSPAGDPPAPVTPGSVHYSTLQQQQQRTREWVARHPQVPETRDHGPVRAWSVLPDDFPRLPSEQGSWVQESESAPAEPPPPSQSLVFPTVSEVWPGDSQLAVFRSIRCQLSLQDLEDFVEQESHGSEESSSGPKESPGGSEDGLRLALGAPDGRRLRNPAGAPPKEARPTRSPQGLRNVGDAHTSQPVSTGADGPAGDPQPLSWPAPKLRRSLRRNSRAGRAKLSSSDEECLQEDLLKRSRRPPRSRKPSRVGAMSSPRVDAALTLAHADIKAAAAAERNHPHSWQVPGGDRLAALVPHRSSEHKSSLVPLDAREHEWIVKLASGSWIRVLSLFWEDPQLALHKDFLTGYTALHWIAKHGALRALQDLASSAQKAGVALDVNVKSSCGYTPLHLAAIHGHQGIIKLLVQRLASRVNIRDSSGKKPWQYLTSNTSGEIWQLLEAPRGKPIFPTYSLVRSSSPTRKVKSQEVSRHVTRKTSLAALLKSQHTKWKLANQYEKCPNLREREEDSA", "length": 777, "header": "tr|A0AAA9SV78-1|A0AAA9SV78_BOVIN Isoform 1 of Sosondowah ankyrin repeat domain family member B OS=Bos taurus OX=9913 GN=SOWAHB PE=3 SV=1 CANONICAL=A0AAA9SV78-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78/entry#A0AAA9SV78-1", "sequence": { "sequence": "MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDAPPSQQQRRRELFKGYVNSVAAVRQDPDGTKYVVLKRRYRDLVGEEEGLRRPRDPPAGAAPAGGAAPGSPLPERRGEHPPQPQPGRRIRREEAPAGAAAPVADAGCNGLPAGGAREAARGGGRPRGRSGHRAPVPAAAVAAAAQDRARCAAAETQGRCCWECLQNGLGGLPDPATASASAAEKLAQDDRGAPRPQWEGVLAEPPPGPATPRSPPATVEAAAPPAVLSSPSPAGDPPAPVTPGSVHYSTLQQQQQRTREWVARHPQVPETRDHGPVRAWSVLPDDFPRLPSEQGSWVQESESAPAEPPPPSQSLVFPTVSEVWPGDSQLAVFRSIRCQLSLQDLEDFVEQESHGSEESSSGPKESPGGSEDGLRLALGAPDGRRLRNPAGAPPKEARPTRSPQGLRNVGDAHTSQPVSTGADGPAGDPQPLSWPAPKLRRSLRRNSRAGRAKLSSSDEECLQEDLLKRSRRPPRSRKPSRVGAMSSPRVDAALTLAHADIKAAAAAERNHPHSWQVPGGDRLAALVPHRSSEHKSSLVPLDAREHEWIVKLASGSWIRVLSLFWEDPQLALHKDFLTGYTALHWIAKHGALRALQDLASSAQKAGVALDVNVKSSCGYTPLHLAAIHGHQGIIKLLVQRLASRVNIRDSSGKKPWQYLTSNTSGEIWQLLEAPRGKPIFPTYSLVRSSSPTRKVKSQEVSRHVTRKTSLAALLKSQHTKWKLANQYEKCPNLREREEDSA", "length": 777, "header": "tr|A0AAA9SV78-1|A0AAA9SV78_BOVIN Isoform 1 of Sosondowah ankyrin repeat domain family member B OS=Bos taurus OX=9913 GN=SOWAHB PE=3 SV=1 CANONICAL=A0AAA9SV78-1" }, "locus": { "chromosome": "6", "start_pos": 91717591, "end_pos": 91711360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106197.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106197.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089235.1" } ] } }, { "isoform_ac": "F1MCD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78/entry#F1MCD1-1", "sequence": { "sequence": "WRRVAPLWAQAGGRVTNAALLSHFKSFLRDPDAPPSQQQRRRELFKGYVNSVAAVRQDPDGTKYVVLKRRYRDLVGEEEGLRRPRDPPAGAAPAGGAAPGSPLPERRGEHPPQPQPGRRIRREEAPAGAAAPVADAGCNGLPAGGAREAARGGGRPRGRSGHRAPVPAAAVAAAAQDRARCAAAETQGRCCWECLQNGLGGLPDPATASASAAEKLAQDDRGAPRPQWEGVLAEPPPGPATPRSPPATVEAAAPPAVLSSPSPAGDPPAPVTPGSVHYSTLQQQQQRTREWVARHPQVPETRDHGPVRAWSVLPDDFPRLPSEQGSWVQESESAPAEPPPPSQSLVFPTVSEVWPGDSQLAVFRSIRCQLSLQDLEDFVEQESHGSEESSSGPKESPGGSEDGLRLALGAPDGRRLRNPAGAPPKEARPTRSPQGLRNVGDAHTSQPVSTGADGPAGDPQPLSWPAPKLRRSLRRNSRAGRAKLSSSDEECLQEDLLKRSRRPPRSRKPSRVGAMSSPRVDAALTLAHADIKAAAAAERNHPHSWQVPGGDRLAALVPHRSSEHKSSLVPLDAREHEWIVKLASGSWIRVLSLFWEDPQLALHKDFLTGYTALHWIAKHGALRALQDLASSAQKAGVALDVNVKSSCGYTPLHLAAIHGHQGIIKLLVQRLASRVNIRDSSGKKPWQYLTSNTSGEIWQLLEAPRGKPIFPTYSLVRSSSPTRKVKSQEVSRHVTRKTSLAALLKSQHTKWKLANQYEKCPNLREREEDSA", "length": 771, "header": "tr|F1MCD1-1|A0AAA9SV78_BOVIN Computationally mapped isoform of Sosondowah ankyrin repeat domain family member B OS=Bos taurus OX=9913 GN=SOWAHB PE=3 SV=4 CANONICAL=A0AAA9SV78-1" }, "locus": { "chromosome": "6", "start_pos": 91737074, "end_pos": 91734620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053025.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053025.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050514.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050514.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 278, "start_aa": "Thr", "end_pos": 278, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr278", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 355, "start_aa": "Thr", "end_pos": 355, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr355", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:512359", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512359", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LBQ6-1", "protein_name": "Sosondowah ankyrin repeat domain family member B", "gene_name": "Sowahb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGELSQEALLDFLCQAGGRVRNAELLSHFKSFLRDPHVPSGQLQERRELFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPAPTDQQPRSHRRLDPEPQKPPAGAGTRVDVGDDELVGSSARKAAGPDPGPGDSPSQRTLGPEAAQARGRCAAVGTRGRCCWECQQNGWGQPTEQPLPEDLGDPAAACEKPERAAPARDDLGAPGWLREGAAAERSPESVTPVWAPAAVEAAGSPTSPPALPPHPAPSREPLELFTAGFPNHSTQQLQQQQQRTREWVARYPLAPEAGIQGPIRAWSVLPDNFLQLPSETAFGVSETNSALPEPALSFHSLLPGVPDESSESWPGNPPLTVFRSIRCQLSLQDLDDFVDQESHGSEESSSGPKESPGTPEEGLQTVLRTSSWGELRDPVEDQFVSPNEGSPCLIPRGLRNRGNVPSFRKAPTVAKSLGDHPQETFPAPKFRRSVRRSSRTGRTKSPSSSDEEHLDEDLLKRSRRPPRSRKPSKAGALPSPRVDVVLIQKLANANAVTGQPHSSWVPGRDGSAALIPHRPSEHRSPLVPLDAREHEWIVRLASGSWFHVQMLFWEDPQLALYRDFLTGYTALHWIAKHGDLNALQDLVSGARKAGVALDVNVRSSCGYTPLHLAAMHGHQGVIKLLVQRLASRVNIRDCSGKKPWQYLNSNVSGETWQLLGAPRGKPIFPVYSLVQSSSPARKVKSREVSRTVTRKTSLAALLKTQHNKWKLASQYEKFHTPKDREEYSD", "length": 767 }, "evidence": [ { "id": "A0AAA9SV78", "url": "https://omabrowser.org/oma/group/A0AAA9SV78/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6NEL2-1", "protein_name": "Ankyrin repeat domain-containing protein SOWAHB", "gene_name": "SOWAHB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRGDGHISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPSPRVDAGLSLKLAEVKAVVAERGWRHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEWIVKLASGSWIQVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGAPRGKPIFPVYPLVGSSSPTRKAKSKEISRSVTRKTSFAALLKSQHNKWKLANQYEKFHSPREREEYSD", "length": 793 }, "evidence": [ { "id": "A0AAA9SV78", "url": "https://omabrowser.org/oma/group/A0AAA9SV78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1RYS6-1", "protein_name": "Sosondowah ankyrin repeat domain family member B", "gene_name": "SOWAHB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARELSQEALLDFLCQAGGRVTNAALLSHFKHFLRDPDAPPGQHQRRRELFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPSDPPATAAPAGGAAPRCPLPACPGESLPPQQPRRRRREKEPEEEPAGAAAAAAVPAAGCNGFPASGVREAPRGGGGRRGSSGPQERVPAAVAAAAQARARCAAAETQGRCCWECLQNGLGGLPGQPLPAALPDPATTTVTACAGEETAQAPPAQDDRRAPRPQREGAPAEPPPVPAASRSRSTTVEAAESWALSPSLLSCSPAPGDPPELVTRGPLLYSTLQQQQQRTREWVARHPQIPEARDRGPIRAWSVLPDDFPRLPPEPGFWVPESKSATPEPPLSSHSVLPAGSESWPGNSPLAVFRSIRCQLSLQDLEDFVDQESHGSEESSSGPKESPGRSDEELHLAPGAPDGRRLRNTAGDPSPKKGSPNGSSQGLGNAGDGHTSQPLPVGADGLEGHPQQPLPWPVPRLRRSLRRSSRAGRARLSSSDEECLEEDLLKRSRRPPRSRKPSKAGAVSSLRVDAALTSKLVDIKAATEQGPPHSPWALGGERPAAFVHHRSSEHKSSLVPLDAREHEWIVKLASGTWNQALTLFWQDPQLALHKDFLTGYTALHWIAKHGDLTALQDLVSGAQKAGIALDVNVKSGCGYTPLHLAAIHGHQAIIRLLVQRLSSRVNVRDSSGKKPWQYLTSNTSGEIWQLLEAPRGKPIFPTQPLVRNSSPTRKAKSREISRSVTRKSSFAALLKSQHNKWKLANQYEKFPTPREREEYSD", "length": 799 }, "evidence": [ { "id": "A0AAA9SV78", "url": "https://omabrowser.org/oma/group/A0AAA9SV78/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BZW2-1", "protein_name": "Ankyrin repeat domain-containing protein SOWAHB", "gene_name": "Sowahb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGELSQEALLDFLCQAGGRVRNAELLSHFKSFLRDPHVSPGQLQERRERFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPGPVDGKPRGHRRRDPEPQKPPAGAGTQVDVGGSAQKVAGPDPSPEDSPNQRTPEPEAAQARGRCAAVGTRGRCCWECQQNGWGQSTGQPLPEDLGDPAVACEKPERAAPARDDLGAPGWLREGEAAEHAPGSVPPVWPPTAVEAAGSPTSPPALPPHPAPSREPLELFTAGSPNHSTQQLQQQHQRTQEWVARYLQVPEPEIQAPTRAWSVLPDNFLQLPSETAFGVSETSSALPEPALSFHSLLPVVLDESSESWPGNAPSTVFRSIRCQLSLQDLNDFVEQESHGSEESSSGPKESPGTPEEGLQPVLRTSSWGELRDPVEDLFLPPNDSPCLIRRDLGYRGNAPSFRKVPTVAKSLGDHPQEPFPALKFRRSVRRSSRTGRTKSPSSSDEEHPDEDLWKRSRRPPRSRKPSKAGALPSPRVDAVLVQKLADANAVASQPHSSWIPSRDGSAALIPHRPSEHRSPLVPLDTREHEWIVRLASGSWLHVLTLFWEDPQLALHRDFLTGYTALHWIAKHGDLCALQDLVSGAQKAGIALDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNIRDCSGKKPWQYLNSNVSGETWQLLGAPRGKPIFPVYSLVQSSSPARKVKSREVSRNVTRKTSLAALLKTQHNKWKLASQYEKIHTSKEREEYSD", "length": 760 }, "evidence": [ { "id": "A0AAA9SV78", "url": "https://omabrowser.org/oma/group/A0AAA9SV78/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SV78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV78" }, { "id": "PF25877", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25877" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOWAHA-C winged helix-turn-helix", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 90, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 278, 355 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 698, "end_pos": 700 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW71-1", "uniprot_ac": "A0AAA9SW71", "uniprot_id": "A0AAA9SW71_BOVIN", "mass": { "chemical_mass": 135399.0, "monoisotopic_mass": 135399.0 }, "refseq": {}, "gene_names": [ { "name": "IGSF3", "type": "recommended", "evidence": [ { "id": "A0AAA9SW71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71" } ] } ], "protein_names": [ { "name": "Immunoglobulin superfamily member 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SW71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGSF3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71", "locus": { "chromosome": "3", "start_pos": 26702307, "end_pos": 26574510, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004849", "url": "https://www.ensembl.org/id/ENSBTAG00000004849" } ] } } ], "crossref": [ { "id": "A0AAA9SW71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00099", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00099", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530939", "url": "https://www.ncbi.nlm.nih.gov/gene/530939", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530939", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530939", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PVSVVWQ", "url": "https://omabrowser.org/oma/group/PVSVVWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJ00", "url": "https://www.orthodb.org/?gene=F1MJ00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12207:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12207:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28276", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28276", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SW71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ00", "url": "https://www.uniprot.org/uniprotkb/F1MJ00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ00-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVSIQEGPLYRTEGSHITIWCNVSGFQGPSEQNFQWSVYMPKAPEREIQIISTMDDTFSYAIYTQRVRSGQIYVERVQGNLALLHIIDLQTRDAGVYECHTPSTDERYFGSYSAKTTVVVIPDTLQATAVPQTLHKVEQDRLELTCDTSTETLQHSHLSVAWLRQRGGEKPVEVIALSRNFVLQSSSDYVQRQSLGEVRLDKLGSTTFRLTIFHLQPFDQGEFYCEATEWIQDPDGSWYPMTRKRSEGTVVNVQPTDKEFTVRLETEKRLYTVGEPMEFRCILEAQNIPDRYFAVSWAFNSSLIASMGPNAVPVLNSEFTHREARGELQVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPVIVLPIKSSIFVDVASNASVILEGDNLHLTCSIRTTGRPLSRFSVIWQLVDRQNRRSNIVWLDRDGTVQPGASYWERNSFGGIQMEQVQPNSFSLSIFNTRKEDEGQYECHVTEWVRAVDNEWQIAGERRASTLVSITALETGFAVTAISRTPGVTYNDSFDLQCIIKPHYLSRVPVSVTWRFQPVGTIEFHGLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNSWMRLAERTSNLLEIRVLQPVTNLQVSKSKRTLTLVENRPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHMSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKRPDSRLKLSQEQGNLSVLETRQVQLECVVLNRTSAASQLLVEWFVWKPNQPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCRVEEWLPSPSGMWYKQAEDTAGQMAVRVTRPDAALQVDTVVPNATVFEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRGSPGPEDGEEEEEEEVEVDEEEDEDPTERTALLSVGADAVFGPEGSPWEGRLRFQMLSPLLYRLTVLQASPQDTGNYSCRVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSSTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1194, "header": "tr|A0AAA9SW71-1|A0AAA9SW71_BOVIN Isoform 1 of Immunoglobulin superfamily member 3 OS=Bos taurus OX=9913 GN=IGSF3 PE=4 SV=1 CANONICAL=A0AAA9SW71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71/entry#A0AAA9SW71-1", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVSIQEGPLYRTEGSHITIWCNVSGFQGPSEQNFQWSVYMPKAPEREIQIISTMDDTFSYAIYTQRVRSGQIYVERVQGNLALLHIIDLQTRDAGVYECHTPSTDERYFGSYSAKTTVVVIPDTLQATAVPQTLHKVEQDRLELTCDTSTETLQHSHLSVAWLRQRGGEKPVEVIALSRNFVLQSSSDYVQRQSLGEVRLDKLGSTTFRLTIFHLQPFDQGEFYCEATEWIQDPDGSWYPMTRKRSEGTVVNVQPTDKEFTVRLETEKRLYTVGEPMEFRCILEAQNIPDRYFAVSWAFNSSLIASMGPNAVPVLNSEFTHREARGELQVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPVIVLPIKSSIFVDVASNASVILEGDNLHLTCSIRTTGRPLSRFSVIWQLVDRQNRRSNIVWLDRDGTVQPGASYWERNSFGGIQMEQVQPNSFSLSIFNTRKEDEGQYECHVTEWVRAVDNEWQIAGERRASTLVSITALETGFAVTAISRTPGVTYNDSFDLQCIIKPHYLSRVPVSVTWRFQPVGTIEFHGLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNSWMRLAERTSNLLEIRVLQPVTNLQVSKSKRTLTLVENRPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHMSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKRPDSRLKLSQEQGNLSVLETRQVQLECVVLNRTSAASQLLVEWFVWKPNQPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCRVEEWLPSPSGMWYKQAEDTAGQMAVRVTRPDAALQVDTVVPNATVFEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRGSPGPEDGEEEEEEEVEVDEEEDEDPTERTALLSVGADAVFGPEGSPWEGRLRFQMLSPLLYRLTVLQASPQDTGNYSCRVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSSTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1194, "header": "tr|A0AAA9SW71-1|A0AAA9SW71_BOVIN Isoform 1 of Immunoglobulin superfamily member 3 OS=Bos taurus OX=9913 GN=IGSF3 PE=4 SV=1 CANONICAL=A0AAA9SW71-1" }, "locus": { "chromosome": "3", "start_pos": 26701303, "end_pos": 26575814, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121112.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121112.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090721.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090721.1" } ] } }, { "isoform_ac": "F1MJ00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71/entry#F1MJ00-1", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVSIQEGPLYRTEGSHITIWCNVSGFQGPSEQNFQWSVYMPKAPEREIQIISTMDDTFSYAIYTQRVRSGQIYVERVQGNLALLHIIDLQTRDAGVYECHTPSTDERYFGSYSAKTTVVVIPDTLQATAVPQTLHKVEQDRLELTCDTSTETLQHSHLSVAWLRQRGGEKPVEVIALSRNFVLQSSSDYVQRQSLGEVRLDKLGSTTFRLTIFHLQPFDQGEFYCEATEWIQDPDGSWYPMTRKRSEGTVVNVQPTDKEFTVRLETEKRLYTVGEPMEFRCILEAQNIPDRYFAVSWAFNSSLIASMGPNAVPVLNSEFTHREARGELQVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPVIVLPITDNWVVKVPQHHQILPQGHLESSIFVDVASNASVILEGDNLHLTCSIRTTGRPLSRFSVIWQLVDRQNRRSNIVWLDRDGTVQPGASYWERNSFGGIQMEQVQPNSFSLSIFNTRKEDEGQYECHVTEWVRAVDNEWQIAGERRASTLVSITALETGFAVTAISRTPGVTYNDSFDLQCIIKPHYLSRVPVSVTWRFQPVGTIEFHGLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNSWMRLAERTSNLLEIRVLQPVTNLQVSKSKRTLTLVENRPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHMSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKRPDSRLKLSQEQGNLSVLETRQVQLECVVLNRTSAASQLLVEWFVWKPNQPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCRVEEWLPSPSGMWYKQAEDTAGQMAVRVTRPDAALQVDTVVPNATVFEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRGSPGPEDGEEEEEEEVEVDEEEDEDPTERTALLSVGADAVFGPEGSPWEGRLRFQMLSPLLYRLTVLQASPQDTGNYSCRVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSSTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1214, "header": "tr|F1MJ00-1|A0AAA9SW71_BOVIN Computationally mapped isoform of Immunoglobulin superfamily member 3 OS=Bos taurus OX=9913 GN=IGSF3 PE=4 SV=5 CANONICAL=A0AAA9SW71-1" }, "locus": { "chromosome": "3", "start_pos": 26701303, "end_pos": 26575814, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006374.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006374.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006374.8", "url": "https://www.ensembl.org/id/ENSBTAP00000006374.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530939", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530939", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K7L2-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "Igsf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKCFFPVLSCLAVLGAVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPAEQNFQWSIYLPSAPEREVQIVSTVDSSFPYAIYTQRVRGGKIYVERIQGNSALLHITDLQARDAGEYECHTPNTDERYFGSYSAKMNLVVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETLQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREAKGQLKVAKEGDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLKSSMSVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTVQPGSSYWERSSYGGIQMEQVQPNSFSLGIFSSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRPIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQAQGSLSILETRQIQLECVVLNRTSMASQLVVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHVESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLLSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKATFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEVSEEEASEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKGWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1190 }, "evidence": [ { "id": "A0AAA9SW71", "url": "https://omabrowser.org/oma/group/A0AAA9SW71/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XZV7-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "IGSF3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPPRPPLTSLLLLIFVLLLGMAFAQRHVAVQEGPLYRTEGSHVTLWCKVSGYQGPAEQTFQWSIYLPSASEREVQIVSTADPSFPYAIYTQRVRAQEIYVERVQGDAVLLHITELQDRDAGEYECHTPNTDERYFGSYSAKTNLTVIPDSLRVTAVPQTLHRVERDSLELKCEVSKSTAQHSHVSISWYRQRGGEAPVEIISLSRDFVLRAGGTYAQRHATGDVRLDKVGETTSKLTIYNLHPSDQGEFYCEAAEWIQDPDKSWYAMTRKRSQGTIVNVQATDKEFSVRLETEKRMYIVGEPVEFRCILEAQNIPDRYFSISWAFNSSLIASLGPNAVPVLNNEFAQREALGQLKVAKESDNVFVLKIYRLRLEDSGKYNCRVTEREKTVTGDFIDKESKRPKNIPITVLPLKTSISLEIVNNASSVLEGESLRFGCNVRSNVGPQSRLSIAWQLVDKQNRRSEIVRLDRDGTLQPGPLYAERSSYGGIQMEQVRPGSFTLEIFNSVRADEGHYECRVAEWMRTLDGEWQIAGERHAGTPVTITALEAGFAVTAISRTPGVTYNESFDLQCIIKPHYPSWVPVSVTWRFQPAGSSEFHDLVTFTRDGGVQWGDRYLGFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNSSWTRLADRTSNLLEIRVLRPVTKLQVSKSKRSITLVENRPIPLNCSVKSQTSPDSHFAVLWYVHKPSDADGKLILKTTHSSAFEYGTYAEEEGLRGRLQFERSASGGLFSLTVQRAEVRDSGSYYCHVEEWLLSPNHAWYKLAEEVSGRTEVTVKQPDNRLHVNQTHRNITVLENQWVTLECQVSSRTSPSSQLQVEWYVWRPGHPEKEAVARLSRQSTLRYGDLATLGNLRSRLHLESPSPGLYLLSIQNATVRDSGTYDCRVEEWLLDPSDRWYKRAEDLSGLTTLTVKQPEPTLQVDTATANLTVQEKESFQLDCSILSRSSPKSHFAVTWYNLRAKEAGGHAEEEEKEEEEEKEVVLSVGLDTIFNSGTGRWQDRLCFQRLSAVLFRLTVLQASGADTGNYSCRVEEWLADPSGMWYRLAEEESGTVAVHVQDAGSTLQSVICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGTID", "length": 1183 }, "evidence": [ { "id": "A0AAA9SW71", "url": "https://omabrowser.org/oma/group/A0AAA9SW71/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O75054-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "IGSF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTEGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTMDSSFPYAIYTQRVRGGKIFIERVQGNSTLLHITDLQARDAGEYECHTPSTDKQYFGSYSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLELTCEVASETIQHSHLSVAWLRQKVGEKPVEVISLSRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPVEFRCILEAQNVPDRYFAVSWAFNSSLIATMGPNAVPVLNSEFAHREARGQLKVAKESDSVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIIVLPLKSSISVEVASNASVILEGEDLRFSCSVRTAGRPQGRFSVIWQLVDRQNRRSNIMWLDRDGTVQPGSSYWERSSFGGVQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTPISITALEMGFAVTAISRTPGVTYSDSFDLQCIIKPHYPAWVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRKNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENKPIQLNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILKTTHNSAFEYGTYAEEEGLRARLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLRLSQAQGNLSVLETRQVQLECVVLNRTSITSQLMVEWFVWKPNHPERETVARLSRDATFHYGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHVEEWLPSPSGMWYKRAEDTAGQTALTVMRPDASLQVDTVVPNATVSEKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAGGKRSSPGLEEQEEEREEEEEEDDDDDDDPTERTALLSVGPDAVFGPEGSPWEGRLRFQRLSPVLYRLTVLQASPQDTGNYSCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSPTLQSIICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSDGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1194 }, "evidence": [ { "id": "A0AAA9SW71", "url": "https://omabrowser.org/oma/group/A0AAA9SW71/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6ZQA6-1", "protein_name": "Immunoglobulin superfamily member 3", "gene_name": "Igsf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYRTESSHITIWCNVSGYQGPSEQNFQWSIYLPSAPEREVQIVSTVDSSFPYAIYTQRVRGGKIYVERIQGNSALLHITDLQARDAGEYECHTPNTDERYFGSYSAKMNLVVIPDSLQTTAVPQTLHKVEQDPLELSCEVATETVQHTHLSVSWLRQKGGENPVEVISLSRDFILHSSSEYAQRQSLGEVRLDKLGRSTFRLTIFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRKRSEGAVVNVQPTDKEFTVRLETDKRLHTVGEPVEFRCILEAQNIPDRYFAVSWAFNSSLIATMGPNAVPVLNSDFAHREAKGQLKVAKESDGVFVLKIYHLRQEDSGKYNCRVTEREKTVTGEFIDKESKRPKNIPIVVLPLKSSISVEVASNASVVLEGEDLHFSCTVRTVGRLQARFSVIWQLVDRQNRRSNVMWLDRDGTLQPGSAYWERSSYGGIQMEQVQPNSFSLGIFNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRASTLVSITALETGFAVTAISRTPGVTYSDSFDLQCIIKPHYPARVPVSVTWRFQPVGTVEFHDLVTFTRDGGVQWGDKSSTFRTRTAIEKAESSNNVRLSISRASDTEAGKYQCVAELWRRNYNNTWTRLAERTSNLLEIRVLQPVTKLQVSKSKRTLTLVENRAIQLNCSVKSQTSPNSHFAVLWYVHKPSDADGKLILKTTHSSAFEYGTYAEEEGLRGRLQFERHVSGGLFSLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQPDSRLKLSQVQGSLSVLETRQIQLECVVLNRTSVASQLLVEWFVWKPNHPEREVVAHLSRDATFHYGEQAAKNNLKGRLHAESPSSGVYRLFIQNVAVQDSGTYSCRVEEWLPSPSGVWYKRAEDTAGQTAVTVMRPDAALQVDTVVPNATVTEKAAFQLDCSILSRSSQDSRFAVAWYSLRTKGGGKRGSLGIDEQEEEEEEEDISQEEDSEDPTERTVLLSVGPDAVFGPEGSPWEGRLRFQRLSPLLYRLTVLEASPQDTGNYSCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTSSTLQSLICSNDALFYFVFFYPFPIFGILIITILLVRFKSRNSSKNSEGKNGVPLLWIKEPHLNYSPTCLEPPVLSIHPGAID", "length": 1194 }, "evidence": [ { "id": "A0AAA9SW71", "url": "https://omabrowser.org/oma/group/A0AAA9SW71/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lacrimal gland development", "id": "GO:0032808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032808", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1077, "end_pos": 1079, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1153, "end_pos": 1155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1175, "end_pos": 1177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 700, "end_pos": 702, "annotation": "n_glycosylation_sequon" }, { "start_pos": 825, "end_pos": 827, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" }, { "start_pos": 961, "end_pos": 963, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SW71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW71" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 138, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1077, "end_pos": 1079 }, { "start_pos": 1153, "end_pos": 1155 }, { "start_pos": 1175, "end_pos": 1177 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 559, "end_pos": 561 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 700, "end_pos": 702 }, { "start_pos": 825, "end_pos": 827 }, { "start_pos": 842, "end_pos": 844 }, { "start_pos": 961, "end_pos": 963 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVD5-1", "uniprot_ac": "A0AAA9SVD5", "uniprot_id": "A0AAA9SVD5_BOVIN", "mass": { "chemical_mass": 85773.0, "monoisotopic_mass": 85773.0 }, "refseq": {}, "gene_names": [ { "name": "LRIF1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ] } ], "protein_names": [ { "name": "Ligand dependent nuclear receptor interacting factor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SVD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRIF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5", "locus": { "chromosome": "3", "start_pos": 32428000, "end_pos": 32408213, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012659", "url": "https://www.ensembl.org/id/ENSBTAG00000012659" } ] } } ], "crossref": [ { "id": "A0AAA9SVD5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539067", "url": "https://www.ncbi.nlm.nih.gov/gene/539067", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3N1T7", "url": "https://www.orthodb.org/?gene=G3N1T7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16131:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16131:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15741", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15741", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1T7", "url": "https://www.uniprot.org/uniprotkb/G3N1T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1T7-1", "url": "https://www.uniprot.org/uniprotkb/G3N1T7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNNPQRVFLKPTEEKSGNASHCVSGCMYQVVQTIGSDGKNLLQLLPIPNSSGNLMPLVQSSVMSDALKGNTGSPVQVTFQTQISSSSTSASVQLPIFQPASSSNYFLTRTVDTAEKVRVTSVGTENFTSSVSKVQSHGVKVDGLTMQTFAVSPSSTQNDSSYILVNTQNLPMTVKSPVLPSGHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTSGTVEPSQIPTVIYVSPVNTVKNVVTKNFQNIYPKPVTEIAKPMILNTTQIPMNVAKETQLKGGQHSQAAPVKWIFQENLQPCTPSLVPVKSSNNVASKILKTFVDRKNLGDNTVNMPPLSTISPTGTQSKSMPIKDNALVMFNGKVYLLAKKGTDVLPSLIDKQNSVSSDIPPRKDASQIVSSSPVTEISREVVNIVLAKSKSSQMETKSVSNTQLASMANLRAEKNKKVEKPSLSAPNPHSMNQSINYLKQSKTLFSKPVLPDGFSTGQNAPRKGNIIQSIEKISSSVDATTVTSQQCVFRDQEPKYCLCVFFSYFQIQNEMASTLEKVTQERNDKNSSQRRSNKVSYLKSDAELKKIFGITKDLRVCLTRIAQQLGSGEGFDSISPLVKSETYKEAEFIVKEEGRKQSYSKLQQGIDKKRKAKTTKKMDHPKKRRTSSVNNTTINGGTNVTSSQLISSILPTSDVSNHNILTSCNKTREKNRTEVEHRTHGNQEKDILNSSTAFEQSHSFNKNYTEDIFPMTPPELEETIRDEKIRRLKQVLREKEAALEEMRKKMHQK", "length": 780, "header": "tr|A0AAA9SVD5-1|A0AAA9SVD5_BOVIN Isoform 1 of Ligand dependent nuclear receptor interacting factor 1 OS=Bos taurus OX=9913 GN=LRIF1 PE=4 SV=1 CANONICAL=A0AAA9SVD5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5/entry#A0AAA9SVD5-1", "sequence": { "sequence": "MSNNPQRVFLKPTEEKSGNASHCVSGCMYQVVQTIGSDGKNLLQLLPIPNSSGNLMPLVQSSVMSDALKGNTGSPVQVTFQTQISSSSTSASVQLPIFQPASSSNYFLTRTVDTAEKVRVTSVGTENFTSSVSKVQSHGVKVDGLTMQTFAVSPSSTQNDSSYILVNTQNLPMTVKSPVLPSGHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTSGTVEPSQIPTVIYVSPVNTVKNVVTKNFQNIYPKPVTEIAKPMILNTTQIPMNVAKETQLKGGQHSQAAPVKWIFQENLQPCTPSLVPVKSSNNVASKILKTFVDRKNLGDNTVNMPPLSTISPTGTQSKSMPIKDNALVMFNGKVYLLAKKGTDVLPSLIDKQNSVSSDIPPRKDASQIVSSSPVTEISREVVNIVLAKSKSSQMETKSVSNTQLASMANLRAEKNKKVEKPSLSAPNPHSMNQSINYLKQSKTLFSKPVLPDGFSTGQNAPRKGNIIQSIEKISSSVDATTVTSQQCVFRDQEPKYCLCVFFSYFQIQNEMASTLEKVTQERNDKNSSQRRSNKVSYLKSDAELKKIFGITKDLRVCLTRIAQQLGSGEGFDSISPLVKSETYKEAEFIVKEEGRKQSYSKLQQGIDKKRKAKTTKKMDHPKKRRTSSVNNTTINGGTNVTSSQLISSILPTSDVSNHNILTSCNKTREKNRTEVEHRTHGNQEKDILNSSTAFEQSHSFNKNYTEDIFPMTPPELEETIRDEKIRRLKQVLREKEAALEEMRKKMHQK", "length": 780, "header": "tr|A0AAA9SVD5-1|A0AAA9SVD5_BOVIN Isoform 1 of Ligand dependent nuclear receptor interacting factor 1 OS=Bos taurus OX=9913 GN=LRIF1 PE=4 SV=1 CANONICAL=A0AAA9SVD5-1" }, "locus": { "chromosome": "3", "start_pos": 32425878, "end_pos": 32408412, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135480.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135480.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089290.1" } ] } }, { "isoform_ac": "G3N1T7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5/entry#G3N1T7-1", "sequence": { "sequence": "MVSRKPWEENVIRKDVSGCMYQVVQTIGSDGKNLLQLLPIPNSSGNLMPLVQSSVMSDALKGNTGSPVQVTFQTQISSSSTSASVQLPIFQPASSSNYFLTRTVDTAEKVRVTSVGTENFTSSVSKVQSHGVKVDGLTMQTFAVSPSSTQNDSSYILVNTQNLPMTVKSPVLPSGHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTSGTVEPSQIPTVIYVSPVNTVKNVVTKNFQNIYPKPVTEIAKPMILNTTQIPMNVAKETQLKGGQHSQAAPVKWIFQENLQPCTPSLVPVKSSNNVASKILKTFVDRKNLGDNTVNMPPLSTISPTGTQSKSMPIKDNALVMFNGKVYLLAKKGTDVLPSLIDKQNSVSSDIPPRKDASQIVSSSPVTEISREVVNIVLAKSKSSQMETKSVSNTQLASMANLRAEKNKKVEKPSLSAPNPHSMNQSINYLKQSKTLFSKPVLPDGFSTGQNAPRKGNIIQSIEKISSSVDATTVTSQQCVFRDQEPKIQNEMASTLEKVTQERNDKNSSQRRSNKVSYLKSDAELKKIFGITKDLRVCLTRIAQQLGSGEGFDSISPLVKSETYKEAEFIVKEEGRKQSYSKLQQGIDKKRKAKTTKKMDHPKKRRTSSVNNTTINGGTNVTSSQLISSILPTSDVSNHNILTSCNKTREKNRTEVEHRTHGNQEKDILNSSTAFEQSHSFNKNYTEDIFPMTPPELEETIRDEKIRRLKQVLREKEAALEEMRKKMHQK", "length": 761, "header": "tr|G3N1T7-1|G3N1T7_BOVIN Computationally mapped isoform of Ligand dependent nuclear receptor interacting factor 1 OS=Bos taurus OX=9913 GN=LRIF1 PE=4 SV=3 CANONICAL=A0AAA9SVD5-1" }, "locus": { "chromosome": "3", "start_pos": 32425878, "end_pos": 32419543, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065409.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065409.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055840.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055840.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 743, "start_aa": "Thr", "end_pos": 743, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr743", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "pmid": "" }, { "name": "Barr body", "id": "GO:0001740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001740", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "pmid": "" }, { "name": "dosage compensation by inactivation of X chromosome", "id": "GO:0009048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009048", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nuclear retinoic acid receptor binding", "id": "GO:0042974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042974", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 670, "end_pos": 672, "annotation": "n_glycosylation_sequon" }, { "start_pos": 696, "end_pos": 698, "annotation": "n_glycosylation_sequon" }, { "start_pos": 702, "end_pos": 704, "annotation": "n_glycosylation_sequon" }, { "start_pos": 720, "end_pos": 722, "annotation": "n_glycosylation_sequon" }, { "start_pos": 734, "end_pos": 736, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 743 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 265, "end_pos": 267 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 557, "end_pos": 559 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 662, "end_pos": 664 }, { "start_pos": 670, "end_pos": 672 }, { "start_pos": 696, "end_pos": 698 }, { "start_pos": 702, "end_pos": 704 }, { "start_pos": 720, "end_pos": 722 }, { "start_pos": 734, "end_pos": 736 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVD6-1", "uniprot_ac": "A0AAA9SVD6", "uniprot_id": "A0AAA9SVD6_BOVIN", "mass": { "chemical_mass": 34692.0, "monoisotopic_mass": 34692.0 }, "refseq": { "ac": "XP_024851069", "name": "rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851069" }, "gene_names": [ { "name": "FBLL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ] }, { "name": "FBLL1", "type": "synonym", "evidence": [ { "id": "XP_024851069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851069" } ] } ], "protein_names": [ { "name": "Fibrillarin like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SVD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6/entry#names_and_taxonomy" } ] }, { "name": "rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1", "type": "synonym", "evidence": [ { "id": "XP_024851069", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851069" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBLL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6", "locus": { "chromosome": "7", "start_pos": 80551102, "end_pos": 80543476, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065270", "url": "https://www.ensembl.org/id/ENSBTAG00000065270" } ] } } ], "crossref": [ { "id": "A0AAA9SVD6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "112447480", "url": "https://www.ncbi.nlm.nih.gov/gene/112447480", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000692", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000692", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112447480", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112447480", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR10335", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10335", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10335:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10335:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01269", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01269", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851069", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851069", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSAVGLRRGGSGGRGGGGWGGGRGGGAGKGAGGDGGGPGGKGGFGARTRGFGGGRGRGRGGAGGDGRGDRGGGGQLRGVAKNKNRRRKSVLTVSVEPHRHEGVFIYRGAEDALVTLNMVPGQSVYGERRVTVTEGGEKLEYRTWNPFRSKLAAAILGGVDQIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSHRAGRDLVNVAKKRTNIIPVLEDARHPLKYRMLIGMVDVIFADVAQPDQSRIVALNAHTFLRNGGHFLISIKANCIDSTASAEAVFASEVRKLQQENLKPQEQLTLEPYERDHAVVVGVYRPLPKSSSK", "length": 330, "header": "tr|A0AAA9SVD6-1|A0AAA9SVD6_BOVIN Isoform 1 of Fibrillarin like 1 OS=Bos taurus OX=9913 GN=FBLL1 PE=3 SV=1 CANONICAL=A0AAA9SVD6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6/entry#A0AAA9SVD6-1", "sequence": { "sequence": "MKSAVGLRRGGSGGRGGGGWGGGRGGGAGKGAGGDGGGPGGKGGFGARTRGFGGGRGRGRGGAGGDGRGDRGGGGQLRGVAKNKNRRRKSVLTVSVEPHRHEGVFIYRGAEDALVTLNMVPGQSVYGERRVTVTEGGEKLEYRTWNPFRSKLAAAILGGVDQIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSHRAGRDLVNVAKKRTNIIPVLEDARHPLKYRMLIGMVDVIFADVAQPDQSRIVALNAHTFLRNGGHFLISIKANCIDSTASAEAVFASEVRKLQQENLKPQEQLTLEPYERDHAVVVGVYRPLPKSSSK", "length": 330, "header": "tr|A0AAA9SVD6-1|A0AAA9SVD6_BOVIN Isoform 1 of Fibrillarin like 1 OS=Bos taurus OX=9913 GN=FBLL1 PE=3 SV=1 CANONICAL=A0AAA9SVD6-1" }, "locus": { "chromosome": "7", "start_pos": 80553120, "end_pos": 80551102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094131.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094131.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090431.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112447480", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112447480", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVF5-1", "uniprot_ac": "A0AAA9SVF5", "uniprot_id": "A0AAA9SVF5_BOVIN", "mass": { "chemical_mass": 21535.0, "monoisotopic_mass": 21535.0 }, "refseq": {}, "gene_names": [ { "name": "PMVK", "type": "recommended", "evidence": [ { "id": "A0AAA9SVF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ] } ], "protein_names": [ { "name": "Phosphomevalonate kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9SVF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5/entry#names_and_taxonomy" } ] }, { "name": "2.7.4.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SVF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5#function" }, { "database": "UniProtKB", "id": "ARBA00057619", "url": "https://www.uniprot.org/uniprotkb/ARBA00057619#function" }, { "database": "UniProtKB", "id": "A0ABI0P6R9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6R9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PMVK", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5", "locus": { "chromosome": "3", "start_pos": 15716280, "end_pos": 15659815, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017819", "url": "https://www.ensembl.org/id/ENSBTAG00000017819" } ] } } ], "crossref": [ { "id": "A0AAA9SVF5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR005919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13101:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13101:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04275", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04275", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "16341", "url": "https://www.rhea-db.org/rhea/16341", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6R9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6R9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6R9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPLGGVPGLVLLFSGKRKSGKDFVTEALQSRLGADVCAILRLSGPLKEQYAQEHGLDFQRLMDASTYKEAYRSDMICWGEEKRQADPGFFCRKIVEGVCQPVWLVSDTRRVSDIQWFQEAYGAVTQTVRVVATEESRQQRGWVFTPGVGWSSTCHEVSIGESHCWYVSPAGCPASIFWGDLVLLFSSGQVWM", "length": 193, "header": "tr|A0AAA9SVF5-1|A0AAA9SVF5_BOVIN Isoform 1 of Phosphomevalonate kinase OS=Bos taurus OX=9913 GN=PMVK PE=4 SV=1 CANONICAL=A0AAA9SVF5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5/entry#A0AAA9SVF5-1", "sequence": { "sequence": "MAPLGGVPGLVLLFSGKRKSGKDFVTEALQSRLGADVCAILRLSGPLKEQYAQEHGLDFQRLMDASTYKEAYRSDMICWGEEKRQADPGFFCRKIVEGVCQPVWLVSDTRRVSDIQWFQEAYGAVTQTVRVVATEESRQQRGWVFTPGVGWSSTCHEVSIGESHCWYVSPAGCPASIFWGDLVLLFSSGQVWM", "length": 193, "header": "tr|A0AAA9SVF5-1|A0AAA9SVF5_BOVIN Isoform 1 of Phosphomevalonate kinase OS=Bos taurus OX=9913 GN=PMVK PE=4 SV=1 CANONICAL=A0AAA9SVF5-1" }, "locus": { "chromosome": "3", "start_pos": 15715819, "end_pos": 15660087, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094996.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094996.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090447.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090447.1" } ] } }, { "isoform_ac": "A0ABI0P6R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5/entry#A0ABI0P6R9-1", "sequence": { "sequence": "MAPLGGVPGLVLLFSGKRKSGKDFVTEALQSRLGADVCAILRLSGPLKEQYAQEHGLDFQRLMDASTYKEAYRSDMICWGEEKRQADPGFFCRKIVEGVCQPVWLVSDTRRVSDIQWFQEAYGAVTQTVRVVATEESRQQRGWVFTPGVDDAESECGLDNFRTFDWVIENHGDEQHLEEQLEHLIEFIRSRL", "length": 192, "header": "tr|A0ABI0P6R9-1|A0ABI0P6R9_BOVIN Computationally mapped isoform of Phosphomevalonate kinase OS=Bos taurus OX=9913 GN=PMVK PE=4 SV=1 CANONICAL=A0AAA9SVF5-1" }, "locus": { "chromosome": "3", "start_pos": 15669470, "end_pos": 15660087, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142428.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142428.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107380.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107380.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "phosphomevalonate kinase activity", "id": "GO:0004631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "geranylgeranyl diphosphate biosynthetic process", "id": "GO:0033386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via desmosterol", "id": "GO:0033489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033489", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via lathosterol", "id": "GO:0033490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "response to cholesterol", "id": "GO:0070723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "farnesyl diphosphate biosynthetic process, mevalonate pathway", "id": "GO:0010142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010142", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "zymosterol biosynthetic process", "id": "GO:0036197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process", "id": "GO:0006695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006695", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" }, { "name": "isopentenyl diphosphate biosynthetic process, mevalonate pathway", "id": "GO:0019287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16341", "name": "", "equation": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KIU2-1", "A0AAA9SVF5-1" ], "evidence": [ { "id": "16341", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16341" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SVF5", "gene_name": "PMVK", "activity": [ { "ec_number": "2.7.4.2", "activity": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP.", "evidence": [ { "id": "A0AAA9SVF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ] }, { "ec_number": "2.7.4.2", "activity": "", "evidence": [ { "id": "A0AAA9SVF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVF5" } ] } ] }, { "uniprot_ac": "Q2KIU2", "gene_name": "PMVK", "activity": [ { "ec_number": "2.7.4.2", "activity": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP.", "evidence": [ { "id": "Q2KIU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU2" } ] }, { "ec_number": "2.7.4.2", "activity": "", "evidence": [ { "id": "Q2KIU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIU2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.4.2", "ec_name": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP.", "evidence": [ { "id": "2.7.4.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.2" }, { "id": "2.7.4.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.4.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVG2-1", "uniprot_ac": "A0AAA9SVG2", "uniprot_id": "A0AAA9SVG2_BOVIN", "mass": { "chemical_mass": 18523.0, "monoisotopic_mass": 18523.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Large ribosomal subunit protein eL21", "type": "recommended", "evidence": [ { "id": "A0AAA9SVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L21", "type": "synonym", "evidence": [ { "id": "A0AAA9SVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SVG2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVG2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20981", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20981", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01157", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01157", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTNTKGKRRGTCYMFSRPFRKHGVVPLATYMRIYRKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVEEDDQKKKEAKEKGTWVQLKHQPAPPREAHFVRTNGKEPELLEPIPYEFMA", "length": 160, "header": "tr|A0AAA9SVG2-1|A0AAA9SVG2_BOVIN Isoform 1 of Large ribosomal subunit protein eL21 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SVG2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2/entry#A0AAA9SVG2-1", "sequence": { "sequence": "MTNTKGKRRGTCYMFSRPFRKHGVVPLATYMRIYRKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVEEDDQKKKEAKEKGTWVQLKHQPAPPREAHFVRTNGKEPELLEPIPYEFMA", "length": 160, "header": "tr|A0AAA9SVG2-1|A0AAA9SVG2_BOVIN Isoform 1 of Large ribosomal subunit protein eL21 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SVG2-1" }, "locus": { "chromosome": "22", "start_pos": 7039556, "end_pos": 7039077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114936.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114936.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087992.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087992.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVG9-1", "uniprot_ac": "A0AAA9SVG9", "uniprot_id": "A0AAA9SVG9_BOVIN", "mass": { "chemical_mass": 34485.0, "monoisotopic_mass": 34485.0 }, "refseq": { "ac": "NP_001377044", "name": "olfactory receptor family 9 subfamily M member 1D", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377044" }, "gene_names": [ { "name": "OR9M1D", "type": "recommended", "evidence": [ { "id": "A0AAA9SVG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9" } ] }, { "name": "OR9M1D", "type": "synonym", "evidence": [ { "id": "NP_001377044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377044" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SVG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 5I1", "type": "synonym", "evidence": [ { "id": "NP_001377044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377044" } ] }, { "name": "olfactory receptor family 9 subfamily M member 1D", "type": "synonym", "evidence": [ { "id": "NP_001377044", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377044" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377044" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9M1D", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9", "locus": { "chromosome": "24", "start_pos": 269167, "end_pos": 270099, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000067694", "url": "https://www.ensembl.org/id/ENSBTAG00000067694" } ] } } ], "crossref": [ { "id": "A0AAA9SVG9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15410", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15410", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529511", "url": "https://www.ncbi.nlm.nih.gov/gene/529511", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377044", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVENSTVKPQFFLLGFSDHPELQSVLFAVFLSIYSVTLMGNLGMILLITASPPLHTPMYFFLRILSFVDACYSSVIAPKLLVDLVSDKKTISYNGCAAQLYFFCFLVDTESFLLTVMAYDRYIAICNPLLYTVIMSKKICCQLAIGAFLGGTMSSVIHTTNTFHLSFCSNEINHFFCDISPLFSLSCTDAYIHDIVLVVFASLVEALCLLTVLPSYILIIAAILKTGSAKGRRKGFSTCASHLIVVSIYHGTLIFIYLRPGAGHSLDIDKVTSVCYTLIIPMLNPLIYSLRNKDVNNAFRKMISRKFLS", "length": 310, "header": "tr|A0AAA9SVG9-1|A0AAA9SVG9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9M1D PE=3 SV=1 CANONICAL=A0AAA9SVG9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9/entry#A0AAA9SVG9-1", "sequence": { "sequence": "MEVENSTVKPQFFLLGFSDHPELQSVLFAVFLSIYSVTLMGNLGMILLITASPPLHTPMYFFLRILSFVDACYSSVIAPKLLVDLVSDKKTISYNGCAAQLYFFCFLVDTESFLLTVMAYDRYIAICNPLLYTVIMSKKICCQLAIGAFLGGTMSSVIHTTNTFHLSFCSNEINHFFCDISPLFSLSCTDAYIHDIVLVVFASLVEALCLLTVLPSYILIIAAILKTGSAKGRRKGFSTCASHLIVVSIYHGTLIFIYLRPGAGHSLDIDKVTSVCYTLIIPMLNPLIYSLRNKDVNNAFRKMISRKFLS", "length": 310, "header": "tr|A0AAA9SVG9-1|A0AAA9SVG9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9M1D PE=3 SV=1 CANONICAL=A0AAA9SVG9-1" }, "locus": { "chromosome": "24", "start_pos": 270099, "end_pos": 269170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087185.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVI1-1", "uniprot_ac": "A0AAA9SVI1", "uniprot_id": "A0AAA9SVI1_BOVIN", "mass": { "chemical_mass": 21084.0, "monoisotopic_mass": 21084.0 }, "refseq": {}, "gene_names": [ { "name": "FAM104A", "type": "recommended", "evidence": [ { "id": "A0AAA9SVI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1" } ] } ], "protein_names": [ { "name": "VCP nuclear cofactor family member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SVI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM104A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1", "locus": {} } ], "crossref": [ { "id": "A0AAA9SVI1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "615081", "url": "https://www.ncbi.nlm.nih.gov/gene/615081", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615081", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615081", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR34763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34763:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34763:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGRGADAGSSGGTGPPEGYSAPAASARAASRAKARGGGRGGRRNTTPSVPSPRGAAPRRSSPSAAMSERLRPRKRRRNGSEEDHHLPPQTKRSSRNPVFHDSWDTETVLVTNGKEKQRGGKMLLVSSSSDSGGSSSSSISSPDRASGPESSLHHLAAGPGPHTPQPAPEPSALCQGPYFHINQTLKEAHFHSLQHRGRPPS", "length": 202, "header": "tr|A0AAA9SVI1-1|A0AAA9SVI1_BOVIN Isoform 1 of VCP nuclear cofactor family member 1 OS=Bos taurus OX=9913 GN=FAM104A PE=4 SV=1 CANONICAL=A0AAA9SVI1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1/entry#A0AAA9SVI1-1", "sequence": { "sequence": "MGGRGADAGSSGGTGPPEGYSAPAASARAASRAKARGGGRGGRRNTTPSVPSPRGAAPRRSSPSAAMSERLRPRKRRRNGSEEDHHLPPQTKRSSRNPVFHDSWDTETVLVTNGKEKQRGGKMLLVSSSSDSGGSSSSSISSPDRASGPESSLHHLAAGPGPHTPQPAPEPSALCQGPYFHINQTLKEAHFHSLQHRGRPPS", "length": 202, "header": "tr|A0AAA9SVI1-1|A0AAA9SVI1_BOVIN Isoform 1 of VCP nuclear cofactor family member 1 OS=Bos taurus OX=9913 GN=FAM104A PE=4 SV=1 CANONICAL=A0AAA9SVI1-1" }, "locus": { "chromosome": "19", "start_pos": 58114436, "end_pos": 58095804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091792.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091792.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088014.1" } ] } }, { "isoform_ac": "A0AAA9TPM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVI1/entry#A0AAA9TPM4-1", "sequence": { "sequence": "MGGRGADAGSSGGTGPPEGYSAPAASARAASRAKARGGGRGGRRNTTPSVPSPRGAAPRRSSPSAAMSERLRPRKRRRNGSEEDHHLPPQTKRSSRNPVFHDSWDTESSSSDSGGSSSSSISSPDRASGPESSLHHLAAGPGPHTPQPAPEPSALCQGPYFHINQTLKEAHFHSLQHRGRPPS", "length": 183, "header": "tr|A0AAA9TPM4-1|A0AAA9TPM4_BOVIN Computationally mapped isoform of VCP nuclear cofactor family member 1 OS=Bos taurus OX=9913 GN=FAM104A PE=4 SV=2 CANONICAL=A0AAA9SVI1-1" }, "locus": { "chromosome": "19", "start_pos": 58114436, "end_pos": 58095804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105690.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105690.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098967.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098967.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615081", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615081", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 }, { "start_pos": 45, "end_pos": 47 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVK3-1", "uniprot_ac": "A0AAA9SVK3", "uniprot_id": "A0AAA9SVK3_BOVIN", "mass": { "chemical_mass": 27883.0, "monoisotopic_mass": 27883.0 }, "refseq": {}, "gene_names": [ { "name": "CFAP299", "type": "recommended", "evidence": [ { "id": "A0AAA9SVK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3" } ] } ], "protein_names": [ { "name": "Cilia- and flagella-associated protein 299", "type": "recommended", "evidence": [ { "id": "A0AAA9SVK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3#function" }, { "database": "UniProtKB", "id": "ARBA00003056", "url": "https://www.uniprot.org/uniprotkb/ARBA00003056#function" }, { "database": "UniProtKB", "id": "A0AAF6ZI53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI53#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP299", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3", "locus": { "chromosome": "6", "start_pos": 95733208, "end_pos": 95026426, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035776", "url": "https://www.ensembl.org/id/ENSBTAG00000035776" } ] } } ], "crossref": [ { "id": "A0AAA9SVK3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "615662", "url": "https://www.ncbi.nlm.nih.gov/gene/615662", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR027887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33588:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33588:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF14713", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14713", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZI53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZI53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "HTRAAELRLSAQRRPRRLLAAPLPKSSLSELRGWIRRPAETLPGAAVQDEGLARQLVELGYRGTGEVVKREDFEARKAAIEIARLAERTQKKTLTSAGKDLHDNFLKALAVREEDNRSGKVSSVIFIRDKNSHGQEVSGYIDYAHRLKTEDFEVYFSGKKRLLPRPTDMSFYNWDSHIAIWNSTPNYQVIADNPEGLLFKYKRDRKILNVDPKAQPGDNSTRSPILTELYTQVVIFDHVSRRKT", "length": 244, "header": "tr|A0AAA9SVK3-1|A0AAA9SVK3_BOVIN Isoform 1 of Cilia- and flagella-associated protein 299 OS=Bos taurus OX=9913 GN=CFAP299 PE=4 SV=1 CANONICAL=A0AAA9SVK3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3/entry#A0AAA9SVK3-1", "sequence": { "sequence": "HTRAAELRLSAQRRPRRLLAAPLPKSSLSELRGWIRRPAETLPGAAVQDEGLARQLVELGYRGTGEVVKREDFEARKAAIEIARLAERTQKKTLTSAGKDLHDNFLKALAVREEDNRSGKVSSVIFIRDKNSHGQEVSGYIDYAHRLKTEDFEVYFSGKKRLLPRPTDMSFYNWDSHIAIWNSTPNYQVIADNPEGLLFKYKRDRKILNVDPKAQPGDNSTRSPILTELYTQVVIFDHVSRRKT", "length": 244, "header": "tr|A0AAA9SVK3-1|A0AAA9SVK3_BOVIN Isoform 1 of Cilia- and flagella-associated protein 299 OS=Bos taurus OX=9913 GN=CFAP299 PE=4 SV=1 CANONICAL=A0AAA9SVK3-1" }, "locus": { "chromosome": "6", "start_pos": 95733060, "end_pos": 95026825, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113114.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113114.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089349.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089349.1" } ] } }, { "isoform_ac": "A0AAF6ZI53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3/entry#A0AAF6ZI53-1", "sequence": { "sequence": "MDQDEALTTVDNIVTQFNTYEDFLDSQITTLDLYYLEDEGLARQLVELGYRGTGEVVKREDFEARKAAIEIARLAERTQKKTLTSAGKDLHDNFLKALAVREEDNRSGKVSSVIFIRDKNSHGQEVSGYIDYAHRLKTEDFEVYFSGKKRLLPRPTDMSFYNWDSHIAIWNSTPNYQVIADNPEGLLFKYKRDRKILNVDPKAQPGDNSTRSPILTELYTQVVIFDHVSRRKT", "length": 233, "header": "tr|A0AAF6ZI53-1|A0AAF6ZI53_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 299 OS=Bos taurus OX=9913 GN=CFAP299 PE=1 SV=1 CANONICAL=A0AAA9SVK3-1" }, "locus": { "chromosome": "6", "start_pos": 95733060, "end_pos": 95026428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050264.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050264.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046997.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046997.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZI53", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI53" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 219, "end_pos": 221 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SVN2-1", "uniprot_ac": "A0AAA9SVN2", "uniprot_id": "A0AAA9SVN2_BOVIN", "mass": { "chemical_mass": 174771.0, "monoisotopic_mass": 174771.0 }, "refseq": { "ac": "XP_024845865", "name": "collagen alpha-1(XXIV) chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845865" }, "gene_names": [ { "name": "COL24A1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2" } ] }, { "name": "COL24A1", "type": "synonym", "evidence": [ { "id": "XP_024845865", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845865" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(XXIV) chain", "type": "recommended", "evidence": [ { "id": "A0AAA9SVN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2/entry#names_and_taxonomy" } ] }, { "name": "collagen alpha-1(XXIV) chain", "type": "synonym", "evidence": [ { "id": "XP_024845865", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845865" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL24A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2", "locus": { "chromosome": "3", "start_pos": 58327605, "end_pos": 57935932, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066113", "url": "https://www.ensembl.org/id/ENSBTAG00000066113" } ] } } ], "crossref": [ { "id": "531254", "url": "https://www.ncbi.nlm.nih.gov/gene/531254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531254", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531254", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845865", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845865", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHLGAHRTRRGQVSHTAKSKLLLHFIVLCVSGGTVHAQDQGIDILHQLGLGGKDVRHSSSVTAVPPSSTPLPQGVHVTESGVILTNDSYIESPLVKILPVNLEQPFTILIGLQSYRVNNAFLFSIRSKNRLQLGVQLLPKKLVVYLGGKQSVFFNYSVHDERWHSFAIAVTNQDVSMFVECGKKYFSRETLSEVQTFDSNSVFTLGSMNNNSVHFEGVVCQLDIIPSAEASASYCRYVKQQCRPGTSLPHTTIVSTKIPENSLLPKRLGEKVLSQDTVTENKSVLDFTNNDSVAVNKQQEHQISRSQLTSLHSQNVSAMDLVNHVIQTKELITEQLIQANLSLPMSHRSLNEPRKKNKDKFISLLNVSDNITQHNDKITGLSPLKKISSSLPHIKQDTIKNLKKAITANLHTNELIELQQILNTTLYRVTDEPSVDNHLDLRKEGEFDPDATYPIENSYETELYDYYYYYEDLNTVLEMENLRGPKGDTGPPGPPGPAGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPDQALSGEKGDQGLSGLMGPPGMQGVKGLKGHPGLPGLQGEQGIPGFTGNIGSRGYPGRQGLAGPDGNPGPKGVRGFIGSPGEVGQLGPEGERGVPGIRGKRGLKGRQGFPGDFGDRGPAGPDGSPGLIGSTGPPGFPGLRGSVGPVGPIGPSGIPGPMGLSGNKGLPGIKGDKGEQGIAGEQGETGYTGDKGAVGFPGPPGMRGKPGPSGQTGDPGPQGPSGPPGPEGFPGDIGIPGQNGPEGSKGFIGNRGPSGPPGLKGTQGEEGPTGSFGELGPRGKPGPKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGVTGSIGEKGERGSPGPVGPQGEKGAMGYPGPPGVPGPMGALGLPGHVGARGPPGIPGPKGRRGPRGPDGPLGEQGIQGTKGETGDQGKRGPRGLIGKTGNPGERGVQGKPGLQGPPGSTGDRGLTGEPGPRGPQGDAGPPGEMGAEGPPGTEGESGLQGEPGTKGDVGPVGSVGAAGEPGLRGEPGAPGEEGLQGKDGLKGNPGGRGLPGEDGEKGETGLPGTTGPLGGPGLMGPPGPEGITGIPGQRGRPGKKGDKGQMGPAGEIGSRGAPGQFGESGLKGARGTRGAVGHLGLMGPAGEPGILGYRGHEGQPGLSGLPGPKGEKGYPGEDNTILGPPGPRGEPGPRGEQGERGEPGAEGYKGHVGIPGPRGATGQQGPPGEPGDQGEQGLKGERGSEGPKGKKGAPGPSGKPGIPGLPGLPGPKGMQGYHGAEGISGNPGKIGLPGKHGLPGIRGSPGRIGLTGSLGPQGAKGSSGPPGSPGVQGPKGEQGLPGQPGIPGKRGHQGAQGDQGPCGESGIKGQPGEHGIQGLMGFQGFPGPKGPQGDAGIVGISGPKGPVGQRGNTGPFGREGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIESHTALQMESYQNTEVTLIDHSAEIFKTLNYLGNLLHTIKHPLGTRDNPAQICKDLLNCEHKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLSPISVTKLEFGIGKVQMNFLHLLSSEATHIITIHCLNTPVWTSPQTSGSGLTLGFKGWNGQIFEENTLLEPKVLSNDCKIQDGSWHKAKFLFHTQDPNQLPVIEVQKLPHLKTERKYYIESSSVCFL", "length": 1709, "header": "tr|A0AAA9SVN2-1|A0AAA9SVN2_BOVIN Isoform 1 of Collagen alpha-1(XXIV) chain OS=Bos taurus OX=9913 GN=COL24A1 PE=4 SV=1 CANONICAL=A0AAA9SVN2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2/entry#A0AAA9SVN2-1", "sequence": { "sequence": "MHLGAHRTRRGQVSHTAKSKLLLHFIVLCVSGGTVHAQDQGIDILHQLGLGGKDVRHSSSVTAVPPSSTPLPQGVHVTESGVILTNDSYIESPLVKILPVNLEQPFTILIGLQSYRVNNAFLFSIRSKNRLQLGVQLLPKKLVVYLGGKQSVFFNYSVHDERWHSFAIAVTNQDVSMFVECGKKYFSRETLSEVQTFDSNSVFTLGSMNNNSVHFEGVVCQLDIIPSAEASASYCRYVKQQCRPGTSLPHTTIVSTKIPENSLLPKRLGEKVLSQDTVTENKSVLDFTNNDSVAVNKQQEHQISRSQLTSLHSQNVSAMDLVNHVIQTKELITEQLIQANLSLPMSHRSLNEPRKKNKDKFISLLNVSDNITQHNDKITGLSPLKKISSSLPHIKQDTIKNLKKAITANLHTNELIELQQILNTTLYRVTDEPSVDNHLDLRKEGEFDPDATYPIENSYETELYDYYYYYEDLNTVLEMENLRGPKGDTGPPGPPGPAGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPDQALSGEKGDQGLSGLMGPPGMQGVKGLKGHPGLPGLQGEQGIPGFTGNIGSRGYPGRQGLAGPDGNPGPKGVRGFIGSPGEVGQLGPEGERGVPGIRGKRGLKGRQGFPGDFGDRGPAGPDGSPGLIGSTGPPGFPGLRGSVGPVGPIGPSGIPGPMGLSGNKGLPGIKGDKGEQGIAGEQGETGYTGDKGAVGFPGPPGMRGKPGPSGQTGDPGPQGPSGPPGPEGFPGDIGIPGQNGPEGSKGFIGNRGPSGPPGLKGTQGEEGPTGSFGELGPRGKPGPKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGVTGSIGEKGERGSPGPVGPQGEKGAMGYPGPPGVPGPMGALGLPGHVGARGPPGIPGPKGRRGPRGPDGPLGEQGIQGTKGETGDQGKRGPRGLIGKTGNPGERGVQGKPGLQGPPGSTGDRGLTGEPGPRGPQGDAGPPGEMGAEGPPGTEGESGLQGEPGTKGDVGPVGSVGAAGEPGLRGEPGAPGEEGLQGKDGLKGNPGGRGLPGEDGEKGETGLPGTTGPLGGPGLMGPPGPEGITGIPGQRGRPGKKGDKGQMGPAGEIGSRGAPGQFGESGLKGARGTRGAVGHLGLMGPAGEPGILGYRGHEGQPGLSGLPGPKGEKGYPGEDNTILGPPGPRGEPGPRGEQGERGEPGAEGYKGHVGIPGPRGATGQQGPPGEPGDQGEQGLKGERGSEGPKGKKGAPGPSGKPGIPGLPGLPGPKGMQGYHGAEGISGNPGKIGLPGKHGLPGIRGSPGRIGLTGSLGPQGAKGSSGPPGSPGVQGPKGEQGLPGQPGIPGKRGHQGAQGDQGPCGESGIKGQPGEHGIQGLMGFQGFPGPKGPQGDAGIVGISGPKGPVGQRGNTGPFGREGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIESHTALQMESYQNTEVTLIDHSAEIFKTLNYLGNLLHTIKHPLGTRDNPAQICKDLLNCEHKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLSPISVTKLEFGIGKVQMNFLHLLSSEATHIITIHCLNTPVWTSPQTSGSGLTLGFKGWNGQIFEENTLLEPKVLSNDCKIQDGSWHKAKFLFHTQDPNQLPVIEVQKLPHLKTERKYYIESSSVCFL", "length": 1709, "header": "tr|A0AAA9SVN2-1|A0AAA9SVN2_BOVIN Isoform 1 of Collagen alpha-1(XXIV) chain OS=Bos taurus OX=9913 GN=COL24A1 PE=4 SV=1 CANONICAL=A0AAA9SVN2-1" }, "locus": { "chromosome": "3", "start_pos": 58326601, "end_pos": 57936594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103663.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103663.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089375.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089375.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 807, "start_aa": "Thr", "end_pos": 807, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr807", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531254", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531254", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1573, "end_pos": 1575, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN2" }, { "id": "PS51461", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51461" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrillar collagen NC1", "eco_id": "ECO_0000259", "start_pos": 1510, "end_pos": 1709, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 807 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 1573, "end_pos": 1575 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 281, "end_pos": 283 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 340, "end_pos": 342 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVN8-1", "uniprot_ac": "A0AAA9SVN8", "uniprot_id": "A0AAA9SVN8_BOVIN", "mass": { "chemical_mass": 32520.0, "monoisotopic_mass": 32520.0 }, "refseq": {}, "gene_names": [ { "name": "CFAP418", "type": "recommended", "evidence": [ { "id": "A0AAA9SVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8" } ] } ], "protein_names": [ { "name": "Cilia- and flagella-associated protein 418", "type": "recommended", "evidence": [ { "id": "A0AAA9SVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in photoreceptor outer segment disk morphogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8#function" }, { "database": "UniProtKB", "id": "ARBA00024819", "url": "https://www.uniprot.org/uniprotkb/ARBA00024819#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP418", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8", "locus": { "chromosome": "14", "start_pos": 69079022, "end_pos": 69055163, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065822", "url": "https://www.ensembl.org/id/ENSBTAG00000065822" } ] } } ], "crossref": [ { "id": "A0AAA9SVN8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33958:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33958:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GGVQVLPTRPTETGYGRAAQRRRRRLLRPRPEPSRGERESQVNRREGWTVVVKPAPGPKATPPPPDRKNRTPTRPSHDLQLLSVFRLRPSLPHSPGPHVLPRLVLEDLSISPRGPTPPPEQAPPLRTRGFPRSAETFEKEDDLDSLINEIFEEPHFDKKHFKLKSKSSGNTSVRASIQGLGKSCSPVYIGGSTVPCGIGTNASPRACDHLRCTACDFWVESYDDYRWDKSCDYLFFRNNMPEFHKLKTKLVKKKGTRAYACQCSWKAVEELTDLQTDHQLRWVCGKH", "length": 287, "header": "tr|A0AAA9SVN8-1|A0AAA9SVN8_BOVIN Isoform 1 of Cilia- and flagella-associated protein 418 OS=Bos taurus OX=9913 GN=CFAP418 PE=4 SV=1 CANONICAL=A0AAA9SVN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8/entry#A0AAA9SVN8-1", "sequence": { "sequence": "GGVQVLPTRPTETGYGRAAQRRRRRLLRPRPEPSRGERESQVNRREGWTVVVKPAPGPKATPPPPDRKNRTPTRPSHDLQLLSVFRLRPSLPHSPGPHVLPRLVLEDLSISPRGPTPPPEQAPPLRTRGFPRSAETFEKEDDLDSLINEIFEEPHFDKKHFKLKSKSSGNTSVRASIQGLGKSCSPVYIGGSTVPCGIGTNASPRACDHLRCTACDFWVESYDDYRWDKSCDYLFFRNNMPEFHKLKTKLVKKKGTRAYACQCSWKAVEELTDLQTDHQLRWVCGKH", "length": 287, "header": "tr|A0AAA9SVN8-1|A0AAA9SVN8_BOVIN Isoform 1 of Cilia- and flagella-associated protein 418 OS=Bos taurus OX=9913 GN=CFAP418 PE=4 SV=1 CANONICAL=A0AAA9SVN8-1" }, "locus": { "chromosome": "14", "start_pos": 69078018, "end_pos": 69055362, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099028.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099028.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088083.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088083.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 116, "start_aa": "Thr", "end_pos": 116, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr116", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8" } ], "pmid": "" }, { "name": "ciliary base", "id": "GO:0097546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 116 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 201, "end_pos": 203 }, { "start_pos": 69, "end_pos": 71 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVR4-1", "uniprot_ac": "A0AAA9SVR4", "uniprot_id": "A0AAA9SVR4_BOVIN", "mass": { "chemical_mass": 36134.0, "monoisotopic_mass": 36134.0 }, "refseq": {}, "gene_names": [ { "name": "KHK", "type": "recommended", "evidence": [ { "id": "A0AAA9SVR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ] } ], "protein_names": [ { "name": "Ketohexokinase", "type": "synonym", "evidence": [ { "id": "A0AAA9SVR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6DM71", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM71#function" }, { "database": "UniProtKB", "id": "ARBA00057271", "url": "https://www.uniprot.org/uniprotkb/ARBA00057271#function" }, { "database": "UniProtKB", "id": "A0AAF6DLZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLZ8#function" }, { "database": "UniProtKB", "id": "A0AAA9TWK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWK1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KHK", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4", "locus": { "chromosome": "11", "start_pos": 72535014, "end_pos": 72549970, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011325", "url": "https://www.ensembl.org/id/ENSBTAG00000011325" } ] } } ], "crossref": [ { "id": "A0AAA9SVR4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR42774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42774:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42774:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM71", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSHLSYPPKPVTNPSPFLASPLAPQGPWWPHHLPSNPQPPAELRLPGLLRPGSFVLDDLRRYSVDLRYMVFQTTGSVPISTVIISEASGSRTILHAYSFLVADFRQRGVDVSQVAWQSRGETPCSCCIINNSNGSRTIVLYDTNLPDVSAKDFEKVELTRFKWIHIEGRNASEQVKMLQRIEQHNARQPPESKIQVSVEVEKPREELYQLFGYGDVVFVSKDVAKHFGFRSAKEALRGLYSRVRKGATLVCAWAEEGADALGPDGRLLHSDAFPPPRVVDTLGAGDTFNAAVIFSLSQGKSMQEALRFGCQVAGKKCGLQGFDGIV", "length": 327, "header": "tr|A0AAA9SVR4-1|A0AAA9SVR4_BOVIN Isoform 1 of Ketohexokinase OS=Bos taurus OX=9913 GN=KHK PE=1 SV=1 CANONICAL=A0AAA9SVR4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4/entry#A0AAA9SVR4-1", "sequence": { "sequence": "MLSHLSYPPKPVTNPSPFLASPLAPQGPWWPHHLPSNPQPPAELRLPGLLRPGSFVLDDLRRYSVDLRYMVFQTTGSVPISTVIISEASGSRTILHAYSFLVADFRQRGVDVSQVAWQSRGETPCSCCIINNSNGSRTIVLYDTNLPDVSAKDFEKVELTRFKWIHIEGRNASEQVKMLQRIEQHNARQPPESKIQVSVEVEKPREELYQLFGYGDVVFVSKDVAKHFGFRSAKEALRGLYSRVRKGATLVCAWAEEGADALGPDGRLLHSDAFPPPRVVDTLGAGDTFNAAVIFSLSQGKSMQEALRFGCQVAGKKCGLQGFDGIV", "length": 327, "header": "tr|A0AAA9SVR4-1|A0AAA9SVR4_BOVIN Isoform 1 of Ketohexokinase OS=Bos taurus OX=9913 GN=KHK PE=1 SV=1 CANONICAL=A0AAA9SVR4-1" }, "locus": { "chromosome": "11", "start_pos": 72542598, "end_pos": 72537470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134342.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134342.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088105.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088105.1" } ] } }, { "isoform_ac": "A0AAA9TWK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4/entry#A0AAA9TWK1-1", "sequence": { "sequence": "MEEKQILCVGLVVLDIINVMDKYPEEDTDSRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSLARGHVADFVLDDLRRYSVDLRYMVFQTTGSVPISTVIISEASGSRTILHAYRNLPDVSAKDFEKVELTRFKWIHIEGRNASEQVKMLQRIEQHNARQPPESKIQVSVEVEKPREELYQLFGYGDVVFVSKDVAKHFGFRSAKEALRGLYSRVRKGATLVCAWAEEGADALGPDGRLLHSDAFPPPRVVDTLGAGDTFNAAVIFSLSQGVGSDTG", "length": 277, "header": "tr|A0AAA9TWK1-1|A0AAA9TWK1_BOVIN Computationally mapped isoform of Ketohexokinase OS=Bos taurus OX=9913 GN=KHK PE=3 SV=1 CANONICAL=A0AAA9SVR4-1" }, "locus": { "chromosome": "11", "start_pos": 72549914, "end_pos": 72536018, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118245.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118245.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101836.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101836.1" } ] } }, { "isoform_ac": "A0AAF6DLZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4/entry#A0AAF6DLZ8-1", "sequence": { "sequence": "MLSSQQPMGNMCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSLARGHVADFLVADFRQRGVDVSQVAWQSRGETPCSCCIINNSNGSRTIVLYDTNLPDVSAKDFEKVELTRFKWIHIEGRNASEQVKMLQRIEQHNARQPPESKIQVSVEVEKPREELYQLFGYGDVVFVSKDVAKHFGFRSAKEALRGLYSRVRKGATLVCAWAEEGADALGPDGRLLHSDAFPPPRVVDTLGAGDTFNAAVIFSLSQGKSMQEALRFGCQVAGKKCGLQGFDGIV", "length": 278, "header": "tr|A0AAF6DLZ8-1|A0AAF6DLZ8_BOVIN Computationally mapped isoform of Ketohexokinase OS=Bos taurus OX=9913 GN=KHK PE=1 SV=2 CANONICAL=A0AAA9SVR4-1" }, "locus": { "chromosome": "11", "start_pos": 72548804, "end_pos": 72537470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015052.8", "url": "https://www.ensembl.org/id/ENSBTAT00000015052.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015052.8", "url": "https://www.ensembl.org/id/ENSBTAP00000015052.8" } ] } }, { "isoform_ac": "A0AAF6DM71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4/entry#A0AAF6DM71-1", "sequence": { "sequence": "MLSSQQPMGNMCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSLARGHVADFVLDDLRRYSVDLRYMVFQTTGSVPISTVIISEASGSRTILHAYRNLPDVSAKDFEKVELTRFKWIHIEGRNASEQVKMLQRIEQHNARQPPESKIQVSVEVEKPREELYQLFGYGDVVFVSKDVAKHFGFRSAKEALRGLYSRVRKGATLVCAWAEEGADALGPDGRLLHSDAFPPPRVVDTLGAGDTFNAAVIFSLSQGKSMQEALRFGCQVAGKKCGLQGFDGIV", "length": 278, "header": "tr|A0AAF6DM71-1|A0AAF6DM71_BOVIN Computationally mapped isoform of Ketohexokinase OS=Bos taurus OX=9913 GN=KHK PE=3 SV=1 CANONICAL=A0AAA9SVR4-1" }, "locus": { "chromosome": "11", "start_pos": 72548804, "end_pos": 72537470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053651.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053651.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052833.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052833.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" }, { "name": "fructose binding", "id": "GO:0070061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070061", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" }, { "name": "ketohexokinase activity", "id": "GO:0004454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004454", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fructose metabolic process", "id": "GO:0006000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" }, { "name": "nucleoside phosphate metabolic process", "id": "GO:0006753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006753", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR4" }, { "id": "PF00294", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00294" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carbohydrate kinase PfkB", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 318, "start_aa": "Ser", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.3", "ec_name": "beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.3" }, { "id": "2.7.1.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 171, "end_pos": 173 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVR8-1", "uniprot_ac": "A0AAA9SVR8", "uniprot_id": "A0AAA9SVR8_BOVIN", "mass": { "chemical_mass": 20751.0, "monoisotopic_mass": 20751.0 }, "refseq": { "ac": "XP_010805377", "name": "ras-related protein Rap-1b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805377" }, "gene_names": [ { "name": "LOC789148", "type": "recommended", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "name": "LOC789148", "type": "synonym", "evidence": [ { "id": "XP_010805377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805377" } ] } ], "protein_names": [ { "name": "small monomeric GTPase", "type": "recommended", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8/entry#names_and_taxonomy" } ] }, { "name": "ras-related protein Rap-1b", "type": "synonym", "evidence": [ { "id": "XP_010805377", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805377" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC789148", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SVR8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVR8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04175", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04175", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789148", "url": "https://www.ncbi.nlm.nih.gov/gene/789148", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789148", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789148", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AAQFNCA", "url": "https://omabrowser.org/oma/group/AAQFNCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010805377", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805377", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SVR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGSKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLARQINRKTPVPGKAHKKSSCQLL", "length": 184, "header": "tr|A0AAA9SVR8-1|A0AAA9SVR8_BOVIN Isoform 1 of small monomeric GTPase OS=Bos taurus OX=9913 GN=LOC789148 PE=4 SV=1 CANONICAL=A0AAA9SVR8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8/entry#A0AAA9SVR8-1", "sequence": { "sequence": "MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGSKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLARQINRKTPVPGKAHKKSSCQLL", "length": 184, "header": "tr|A0AAA9SVR8-1|A0AAA9SVR8_BOVIN Isoform 1 of small monomeric GTPase OS=Bos taurus OX=9913 GN=LOC789148 PE=4 SV=1 CANONICAL=A0AAA9SVR8-1" }, "locus": { "chromosome": "7", "start_pos": 21534796, "end_pos": 21534245, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090594.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090594.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:789148", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789148", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Rap protein signal transduction", "id": "GO:0032486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032486", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", "gene_name": "RIT1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YXF5", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAF6YXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YXF5" } ] } ] }, { "uniprot_ac": "A0AAF6Z672", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0AAF6Z672", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z672" } ] } ] }, { "uniprot_ac": "A0ABI0NND0", "gene_name": "RAB40C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NND0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NND0" } ] } ] }, { "uniprot_ac": "A0ABI0NZ89", "gene_name": "LOC616304", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0ABI0NZ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ89" } ] } ] }, { "uniprot_ac": "A0ABI0P4Y3", "gene_name": "LOC132344468", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "A0ABI0P4Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4Y3" } ] } ] }, { "uniprot_ac": "A4FUD1", "gene_name": "GPN1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4FUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A5D7J5", "gene_name": "RHOU", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A5D7J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7J5" } ] } ] }, { "uniprot_ac": "A6H7F2", "gene_name": "GPN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6H7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F2" } ] } ] }, { "uniprot_ac": "A6H7I5", "gene_name": "DNM2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A6H7I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I5" } ] } ] }, { "uniprot_ac": "A6QLJ3", "gene_name": "GUF1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ3" } ] } ] }, { "uniprot_ac": "A6QNM2", "gene_name": "GFM2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6QNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM2" } ] } ] }, { "uniprot_ac": "A6QP66", "gene_name": "RERGL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P49410", "gene_name": "TUFM", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "P49410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P49410" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DA0", "gene_name": "RABL6", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DA0" } ] } ] }, { "uniprot_ac": "Q08DF4", "gene_name": "DNM1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08DF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DF4" } ] } ] }, { "uniprot_ac": "Q08DI5", "gene_name": "RAP2C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMJ6", "gene_name": "RHOC", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMJ6" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q27957", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q27957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27957" } ] } ] }, { "uniprot_ac": "Q29RR0", "gene_name": "RAB26", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q29RR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RR0" } ] } ] }, { "uniprot_ac": "Q2HJ68", "gene_name": "RND1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ68" } ] } ] }, { "uniprot_ac": "Q2HJ86", "gene_name": "TUBA1D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ86" } ] } ] }, { "uniprot_ac": "Q2HJB8", "gene_name": "TUBA8", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJB8" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2HJG3", "gene_name": "RHOH", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJG3" } ] } ] }, { "uniprot_ac": "Q2HJH2", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJH2" } ] } ] }, { "uniprot_ac": "Q2HJI8", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2HJI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJI8" } ] } ] }, { "uniprot_ac": "Q2KHU8", "gene_name": "EIF2S3", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q2KHU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU8" } ] } ] }, { "uniprot_ac": "Q2KHZ2", "gene_name": "HBS1L", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2KHZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ2" } ] } ] }, { "uniprot_ac": "Q2KI07", "gene_name": "ARL8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KI07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI07" } ] } ] }, { "uniprot_ac": "Q2KIA5", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q2KIA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIA5" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q2T9U1", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "Q2T9U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9U1" } ] } ] }, { "uniprot_ac": "Q2TA29", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TA29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA29" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q2YDM7", "gene_name": "LSG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] } ] }, { "uniprot_ac": "Q32KN8", "gene_name": "TUBA3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN8" } ] } ] }, { "uniprot_ac": "Q32KW9", "gene_name": "IRGC", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" } ] } ] }, { "uniprot_ac": "Q32LJ6", "gene_name": "RABL3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] } ] }, { "uniprot_ac": "Q32PH8", "gene_name": "EEF1A2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3MHP5", "gene_name": "DRG1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3MHP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP5" } ] } ] }, { "uniprot_ac": "Q3SWY9", "gene_name": "RAB28", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SWY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY9" } ] } ] }, { "uniprot_ac": "Q3SX43", "gene_name": "RRAGA", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SX43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX43" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZA1", "gene_name": "RHOF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3SZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA1" } ] } ] }, { "uniprot_ac": "Q3T054", "gene_name": "RAN", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3T054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T054" } ] } ] }, { "uniprot_ac": "Q3T0D7", "gene_name": "SAR1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0D7" } ] } ] }, { "uniprot_ac": "Q3T0F5", "gene_name": "RAB7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0F5" } ] } ] }, { "uniprot_ac": "Q3T0T7", "gene_name": "SAR1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3T0T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T7" } ] } ] }, { "uniprot_ac": "Q3ZBW5", "gene_name": "RHOB", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZBW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW5" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q3ZCJ7", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3ZCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCJ7" } ] } ] }, { "uniprot_ac": "Q56JV3", "gene_name": "RHEB", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q56JV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV3" } ] } ] }, { "uniprot_ac": "Q58D56", "gene_name": "DRG2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ] } ] }, { "uniprot_ac": "Q58D72", "gene_name": "ATL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q58D72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D72" } ] } ] }, { "uniprot_ac": "Q58DC5", "gene_name": "GTPBP1", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "Q58DC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC5" } ] } ] }, { "uniprot_ac": "Q58DS5", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS5" } ] } ] }, { "uniprot_ac": "Q58DS9", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DS9" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q8HZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ5" } ] } ] }, { "uniprot_ac": "Q9TU25", "gene_name": "RAC2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9TU25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU25" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.5.2", "ec_name": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "3.6.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2" }, { "id": "3.6.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVS6-1", "uniprot_ac": "A0AAA9SVS6", "uniprot_id": "A0AAA9SVS6_BOVIN", "mass": { "chemical_mass": 30343.0, "monoisotopic_mass": 30343.0 }, "refseq": { "ac": "XP_005225853", "name": "nanos homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225853" }, "gene_names": [ { "name": "NANOS1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ] }, { "name": "NANOS1", "type": "synonym", "evidence": [ { "id": "XP_005225853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225853" } ] } ], "protein_names": [ { "name": "Nanos C2HC-type zinc finger 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SVS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6/entry#names_and_taxonomy" } ] }, { "name": "nanos homolog 1", "type": "synonym", "evidence": [ { "id": "XP_005225853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225853" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NANOS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6", "locus": { "chromosome": "26", "start_pos": 39243503, "end_pos": 39238302, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057699", "url": "https://www.ensembl.org/id/ENSBTAG00000057699" } ] } } ], "crossref": [ { "id": "786356", "url": "https://www.ncbi.nlm.nih.gov/gene/786356", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786356", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786356", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12887", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12887", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05741", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05741", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225853", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAFPWAPRSPRRGRAPPPMALVPSARYVSTQGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGDGGGDGSPPSSSSSSCCSPHVGAGPGALGPALGPPDYDEDDDDDDSDDPGSRSRYLGGALELRALELCADPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATAEAAPREERAPAWAAEPKLHAASGAAAARLLKPELQVCVFCRNNKEAVALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPAARPPPRSARDGLPGKKLR", "length": 293, "header": "tr|A0AAA9SVS6-1|A0AAA9SVS6_BOVIN Isoform 1 of Nanos C2HC-type zinc finger 1 OS=Bos taurus OX=9913 GN=NANOS1 PE=3 SV=1 CANONICAL=A0AAA9SVS6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6/entry#A0AAA9SVS6-1", "sequence": { "sequence": "MEAFPWAPRSPRRGRAPPPMALVPSARYVSTQGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGDGGGDGSPPSSSSSSCCSPHVGAGPGALGPALGPPDYDEDDDDDDSDDPGSRSRYLGGALELRALELCADPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATAEAAPREERAPAWAAEPKLHAASGAAAARLLKPELQVCVFCRNNKEAVALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPAARPPPRSARDGLPGKKLR", "length": 293, "header": "tr|A0AAA9SVS6-1|A0AAA9SVS6_BOVIN Isoform 1 of Nanos C2HC-type zinc finger 1 OS=Bos taurus OX=9913 GN=NANOS1 PE=3 SV=1 CANONICAL=A0AAA9SVS6-1" }, "locus": { "chromosome": "26", "start_pos": 39241471, "end_pos": 39240593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130826.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130826.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089503.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089503.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786356", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786356", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "epithelial cell migration", "id": "GO:0010631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" }, { "name": "mRNA destabilization", "id": "GO:0061157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" }, { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS6" }, { "id": "PS51522", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nanos-type", "eco_id": "ECO_0000259", "start_pos": 213, "end_pos": 267, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVT3-1", "uniprot_ac": "A0AAA9SVT3", "uniprot_id": "A0AAA9SVT3_BOVIN", "mass": { "chemical_mass": 57454.0, "monoisotopic_mass": 57454.0 }, "refseq": {}, "gene_names": [ { "name": "KIF25", "type": "recommended", "evidence": [ { "id": "A0AAA9SVT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ] } ], "protein_names": [ { "name": "Kinesin-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SVT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIF25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3", "locus": { "chromosome": "9", "start_pos": 102444694, "end_pos": 102410506, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007694", "url": "https://www.ensembl.org/id/ENSBTAG00000007694" } ] } } ], "crossref": [ { "id": "A0AAA9SVT3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47972:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47972:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VKCRPQVWAQCWEGAGACLCAWRACLGLAAAMPIMLVLWVLVLQKLKREMEALRSSSRGLLQSYREEYRDCLSEIVQAVQTAQLHCEALLACSAEAGRLEQSLRDVTERWQRELRERRRLQDALVELKGNIRVHCRIRPLLPFDDEAQEPVSPDSSVSGGVVHAVDDETVLVECNRPGHALINKTYTFERVYGPAESQRAVFEDVCPLLTSFLDGYNVCIMAYGQTGSGKSFTMLGPHCQEEPALPSEPRGDTGIIPRAAAELFRLISEDPSRSPEVGVSVVEIYNNDIFDLLANDGCRAASGAKRQVLPTQQGKTVVCGSVRSAAQFLMLVGRGLKLRAKQPTSVHAESSRSHLVITVTLATATSPPWSDRSASAEPCQPGPRSPATGRRQSPPVPLRTRGHGLGRAAQDRLGQVRATLQLVDLAGSECAGVSGVTGPALRETSCINRSLAALSDVLGALAEGRGHIPYRNSRLTHLLQDALGGDAKLQVIVCVSPGQRHVVETLQSLGFGARARQVERGHPAPRKLR", "length": 529, "header": "tr|A0AAA9SVT3-1|A0AAA9SVT3_BOVIN Isoform 1 of Kinesin-like protein OS=Bos taurus OX=9913 GN=KIF25 PE=3 SV=1 CANONICAL=A0AAA9SVT3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3/entry#A0AAA9SVT3-1", "sequence": { "sequence": "VKCRPQVWAQCWEGAGACLCAWRACLGLAAAMPIMLVLWVLVLQKLKREMEALRSSSRGLLQSYREEYRDCLSEIVQAVQTAQLHCEALLACSAEAGRLEQSLRDVTERWQRELRERRRLQDALVELKGNIRVHCRIRPLLPFDDEAQEPVSPDSSVSGGVVHAVDDETVLVECNRPGHALINKTYTFERVYGPAESQRAVFEDVCPLLTSFLDGYNVCIMAYGQTGSGKSFTMLGPHCQEEPALPSEPRGDTGIIPRAAAELFRLISEDPSRSPEVGVSVVEIYNNDIFDLLANDGCRAASGAKRQVLPTQQGKTVVCGSVRSAAQFLMLVGRGLKLRAKQPTSVHAESSRSHLVITVTLATATSPPWSDRSASAEPCQPGPRSPATGRRQSPPVPLRTRGHGLGRAAQDRLGQVRATLQLVDLAGSECAGVSGVTGPALRETSCINRSLAALSDVLGALAEGRGHIPYRNSRLTHLLQDALGGDAKLQVIVCVSPGQRHVVETLQSLGFGARARQVERGHPAPRKLR", "length": 529, "header": "tr|A0AAA9SVT3-1|A0AAA9SVT3_BOVIN Isoform 1 of Kinesin-like protein OS=Bos taurus OX=9913 GN=KIF25 PE=3 SV=1 CANONICAL=A0AAA9SVT3-1" }, "locus": { "chromosome": "9", "start_pos": 102444596, "end_pos": 102414465, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112713.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112713.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087301.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087301.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT3" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 518, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 183, "end_pos": 185 }, { "start_pos": 448, "end_pos": 450 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVV3-1", "uniprot_ac": "A0AAA9SVV3", "uniprot_id": "A0AAA9SVV3_BOVIN", "mass": { "chemical_mass": 15814.0, "monoisotopic_mass": 15814.0 }, "refseq": { "ac": "XP_024841152", "name": "lITAF domain-containing protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841152" }, "gene_names": [ { "name": "LITAFD", "type": "recommended", "evidence": [ { "id": "A0AAA9SVV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3" } ] }, { "name": "LITAFD", "type": "synonym", "evidence": [ { "id": "XP_024841152", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841152" } ] } ], "protein_names": [ { "name": "LITAF domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SVV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3/entry#names_and_taxonomy" } ] }, { "name": "lITAF domain-containing protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024841152", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841152" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LITAFD", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3", "locus": { "chromosome": "25", "start_pos": 7712619, "end_pos": 7712202, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059229", "url": "https://www.ensembl.org/id/ENSBTAG00000059229" } ] } } ], "crossref": [ { "id": "A0AAA9SVV3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "101906055", "url": "https://www.ncbi.nlm.nih.gov/gene/101906055", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23292:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23292:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10601", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10601", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841152", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841152", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGASRGQHRAAPSLEPKAASTPLPEQTSWAPGGYYAQGPPPPYSPSPPGLGAPPPPPPMSVYPELFRVPRLQSPDPVQFTCPYCMNRIVTVTTPVPGVLTWLLCTGIFVAGCFLGCCLVPFCVDSLMDVRHTCPVCRQELFLYKRL", "length": 146, "header": "tr|A0AAA9SVV3-1|A0AAA9SVV3_BOVIN Isoform 1 of LITAF domain-containing protein OS=Bos taurus OX=9913 GN=LITAFD PE=3 SV=2 CANONICAL=A0AAA9SVV3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3/entry#A0AAA9SVV3-1", "sequence": { "sequence": "MGASRGQHRAAPSLEPKAASTPLPEQTSWAPGGYYAQGPPPPYSPSPPGLGAPPPPPPMSVYPELFRVPRLQSPDPVQFTCPYCMNRIVTVTTPVPGVLTWLLCTGIFVAGCFLGCCLVPFCVDSLMDVRHTCPVCRQELFLYKRL", "length": 146, "header": "tr|A0AAA9SVV3-1|A0AAA9SVV3_BOVIN Isoform 1 of LITAF domain-containing protein OS=Bos taurus OX=9913 GN=LITAFD PE=3 SV=2 CANONICAL=A0AAA9SVV3-1" }, "locus": { "chromosome": "25", "start_pos": 7712619, "end_pos": 7708894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125482.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125482.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088148.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088148.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVV3" }, { "id": "PS51837", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51837" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LITAF", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 145, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVX9-1", "uniprot_ac": "A0AAA9SVX9", "uniprot_id": "A0AAA9SVX9_BOVIN", "mass": { "chemical_mass": 36341.0, "monoisotopic_mass": 36341.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SVX9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24249:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24249:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GNTGLIPGGRIKIPHLCYEHLNGSCVKTPYSPGPRLILYTVFIFGAVRTVFGNLLVMISILHFKQLHSPANFLITSLACADFLVGVTVTPFSTVRSMESCWYFGESYCQLHSCFEGSFCYASIYHLCFISLDRYIAVTDPLVYPTKFTVSVSGMCIVFSWLFPIIYTFSLLGTGVNAAGLEDLVSALTCVGGCQIAVNQSWVLVNFLLFFIPTLAMIVLYSKISSLLNNSLGDRERKAARTLGMAVLAFLVSWLPYFLDSIIDAFLGFITPTYVYEILVWIAYYNSAMNPLIYAFFYPWFRKAIKLIVTGKVLRENSSTIHLFSE", "length": 325, "header": "tr|A0AAA9SVX9-1|A0AAA9SVX9_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SVX9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9/entry#A0AAA9SVX9-1", "sequence": { "sequence": "GNTGLIPGGRIKIPHLCYEHLNGSCVKTPYSPGPRLILYTVFIFGAVRTVFGNLLVMISILHFKQLHSPANFLITSLACADFLVGVTVTPFSTVRSMESCWYFGESYCQLHSCFEGSFCYASIYHLCFISLDRYIAVTDPLVYPTKFTVSVSGMCIVFSWLFPIIYTFSLLGTGVNAAGLEDLVSALTCVGGCQIAVNQSWVLVNFLLFFIPTLAMIVLYSKISSLLNNSLGDRERKAARTLGMAVLAFLVSWLPYFLDSIIDAFLGFITPTYVYEILVWIAYYNSAMNPLIYAFFYPWFRKAIKLIVTGKVLRENSSTIHLFSE", "length": 325, "header": "tr|A0AAA9SVX9-1|A0AAA9SVX9_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SVX9-1" }, "locus": { "chromosome": "9", "start_pos": 70739497, "end_pos": 70738132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087355.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087355.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "trace-amine receptor activity", "id": "GO:0001594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 293, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 198, "end_pos": 200 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 22, "end_pos": 24 }, { "start_pos": 316, "end_pos": 318 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVY4-1", "uniprot_ac": "A0AAA9SVY4", "uniprot_id": "A0AAA9SVY4_BOVIN", "mass": { "chemical_mass": 21877.0, "monoisotopic_mass": 21877.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112442960", "type": "recommended", "evidence": [ { "id": "A0AAA9SVY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4" } ] } ], "protein_names": [ { "name": "TAFII28-like protein domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SVY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112442960", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4", "locus": {} } ], "crossref": [ { "id": "cd08048", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08048", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EMFPMPR", "url": "https://omabrowser.org/oma/group/EMFPMPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13218:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13218:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04719", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04719", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SASGRAQGSSFLSVPLGPEPSNPGRILPRDPAQNARKASDEEGGELVHQDCPQPRAGEEADSSSRSPVAKRRKVDTEGKRGRQREVGEEEAQKMRTLVAAMSKEQLNRYEVFRRSAFPKSTIKHLIQAVAGTPVSQNVVIAMSGMAKVFVGEVVEEALDVCEKWGEKPPLQPKHLREAVRRLREKGQMPSTKHKILFF", "length": 198, "header": "tr|A0AAA9SVY4-1|A0AAA9SVY4_BOVIN Isoform 1 of TAFII28-like protein domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442960 PE=3 SV=1 CANONICAL=A0AAA9SVY4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4/entry#A0AAA9SVY4-1", "sequence": { "sequence": "SASGRAQGSSFLSVPLGPEPSNPGRILPRDPAQNARKASDEEGGELVHQDCPQPRAGEEADSSSRSPVAKRRKVDTEGKRGRQREVGEEEAQKMRTLVAAMSKEQLNRYEVFRRSAFPKSTIKHLIQAVAGTPVSQNVVIAMSGMAKVFVGEVVEEALDVCEKWGEKPPLQPKHLREAVRRLREKGQMPSTKHKILFF", "length": 198, "header": "tr|A0AAA9SVY4-1|A0AAA9SVY4_BOVIN Isoform 1 of TAFII28-like protein domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442960 PE=3 SV=1 CANONICAL=A0AAA9SVY4-1" }, "locus": { "chromosome": "20", "start_pos": 55678485, "end_pos": 55677799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150835.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150835.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106653.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1W2PQ09-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 11", "gene_name": "TAF11L11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQRDASAEMFPMPRGLKYSNKDGIPEDLDGNLEEPRDQESELRSQDVMDLTEGDNEASASTPPSAKRQKTDTKGKKERKPTMDAEEAQRMTTLFSAMSEEQLSRYEVCRRSAFPKARIAALMQSITGRSVSENTAIAMAGIAKVFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGILPNSNYKKIMF", "length": 198 }, "evidence": [ { "id": "A0AAA9SVY4", "url": "https://omabrowser.org/oma/group/A0AAA9SVY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "RNA polymerase II preinitiation complex assembly", "id": "GO:0051123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVY4" }, { "id": "PF04719", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04719" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TAFII28-like protein", "eco_id": "ECO_0000259", "start_pos": 97, "end_pos": 181, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW11-1", "uniprot_ac": "A0AAA9SW11", "uniprot_id": "A0AAA9SW11_BOVIN", "mass": { "chemical_mass": 61993.0, "monoisotopic_mass": 61993.0 }, "refseq": {}, "gene_names": [ { "name": "TTC34", "type": "recommended", "evidence": [ { "id": "A0AAA9SW11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 34", "type": "synonym", "evidence": [ { "id": "A0AAA9SW11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11", "locus": { "chromosome": "16", "start_pos": 50263472, "end_pos": 50241109, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001642", "url": "https://www.ensembl.org/id/ENSBTAG00000001642" } ] } } ], "crossref": [ { "id": "A0AAA9SW11", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW11", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001642", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001642", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44874", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44874", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44874:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44874:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SW11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5B7", "url": "https://www.uniprot.org/uniprotkb/F1N5B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5B7-1", "url": "https://www.uniprot.org/uniprotkb/F1N5B7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRFSRQEYWSGVPLLSWGPSIPGSSCVPVGAQAHSQEGPGVIPSLATLLMELDTEDEVSRLLAADALYRLGRLDDAHKALLAALSRRPQAAPVLARLALLQLRRGFSYDANQLVKKVVQSGDTACLQSTLAVFSHEDRQLLWGHCHARALAILRARPGGAEGGAHTREAIAYLSLAIFASGKSLPATESLLARARCYGFLGQKKTAMFDFTSVLRTEPGNAQALCGRALLHLALDKQKEAVDDILSALRLSPKTAVPEIRSLKPEAQALITQSLSSRCRALLSQLPDTGARLSDKDAQNLLAAGKALIEIDARQPLWHMLLADALAAVGSFEEAGAHLQKVLHPTPPSEAARARRGLLRLKKGDVVAAAQDLQCLAEMDAQDLGFLLCLLEASERQSLTQAAVQEADTLLNLGQPRQALGYCSLAILAGGSSTCHLRRRATCLAELREFSRALGDLDHVLREGSRDSDLQTQVEDFCSRGRLLLALGDEAGAAGAFAQALHLAPTQAQSSLWERPGRAPASHILLCQARCCLVEQRYSEAWTVAEAGLLLDPEHSGLKRLKARIRREASSGCRLY", "length": 575, "header": "tr|A0AAA9SW11-1|A0AAA9SW11_BOVIN Isoform 1 of Tetratricopeptide repeat domain 34 OS=Bos taurus OX=9913 GN=TTC34 PE=4 SV=2 CANONICAL=A0AAA9SW11-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11/entry#A0AAA9SW11-1", "sequence": { "sequence": "MRFSRQEYWSGVPLLSWGPSIPGSSCVPVGAQAHSQEGPGVIPSLATLLMELDTEDEVSRLLAADALYRLGRLDDAHKALLAALSRRPQAAPVLARLALLQLRRGFSYDANQLVKKVVQSGDTACLQSTLAVFSHEDRQLLWGHCHARALAILRARPGGAEGGAHTREAIAYLSLAIFASGKSLPATESLLARARCYGFLGQKKTAMFDFTSVLRTEPGNAQALCGRALLHLALDKQKEAVDDILSALRLSPKTAVPEIRSLKPEAQALITQSLSSRCRALLSQLPDTGARLSDKDAQNLLAAGKALIEIDARQPLWHMLLADALAAVGSFEEAGAHLQKVLHPTPPSEAARARRGLLRLKKGDVVAAAQDLQCLAEMDAQDLGFLLCLLEASERQSLTQAAVQEADTLLNLGQPRQALGYCSLAILAGGSSTCHLRRRATCLAELREFSRALGDLDHVLREGSRDSDLQTQVEDFCSRGRLLLALGDEAGAAGAFAQALHLAPTQAQSSLWERPGRAPASHILLCQARCCLVEQRYSEAWTVAEAGLLLDPEHSGLKRLKARIRREASSGCRLY", "length": 575, "header": "tr|A0AAA9SW11-1|A0AAA9SW11_BOVIN Isoform 1 of Tetratricopeptide repeat domain 34 OS=Bos taurus OX=9913 GN=TTC34 PE=4 SV=2 CANONICAL=A0AAA9SW11-1" }, "locus": { "chromosome": "16", "start_pos": 50263469, "end_pos": 50251130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128731.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128731.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087396.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087396.2" } ] } }, { "isoform_ac": "F1N5B7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW11/entry#F1N5B7-1", "sequence": { "sequence": "AHQASPSLGFSRQEHWSGLPFPSPMDAHGVHQLATLLMELDTEDEVSRLLAADALYRLGRLDDAHKALLAALSRRPQAAPVLARLALLQLRRGFSYDANQLVKKVVQSGDTACLQSTLAVFSHEDRQLLWGHCHARALAILRARPGGAEGGAHTREAIAYLSLAIFASGNQATESLLARARCYGFLGQKKTAMFDFTSVLRTEPGNAQALCGRALLHLALDKQKEAVDDILSALRLSPKTAVPEIRSLKPEAQALITQSLSSRCRALLSQLPDTGARLSDKDAQNLLAAGKALIEIDARQPLWHMLLADALAAVGSFEEAGAHLQKVLHPTPPSEAARARRGLLRLKKGDVVAAAQDLQCLAEMDAQDLGFLLCLLEASERQSLTQAAVQEADTLLNLGQPRQALGYCSLAILAGGSSTCHLRRRATCLAELREFSRALGDLDHVLREGSRDSDLQTQVEDFCSRGRLLLALGDEAGAAGAFAQALHLAPTQAQSSLWERPGRAPASHILLCQARCCLVEQRYSEAWTVAEAGLLLDPEHSGLKRLKARIRREASSGCRLY", "length": 561, "header": "tr|F1N5B7-1|F1N5B7_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 34 OS=Bos taurus OX=9913 GN=TTC34 PE=4 SV=4 CANONICAL=A0AAA9SW11-1" }, "locus": { "chromosome": "16", "start_pos": 50263469, "end_pos": 50250967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056442.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056442.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052521.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052521.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 345, "start_aa": "Thr", "end_pos": 345, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr345", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 345 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW44-1", "uniprot_ac": "A0AAA9SW44", "uniprot_id": "A0AAA9SW44_BOVIN", "mass": { "chemical_mass": 19372.0, "monoisotopic_mass": 19372.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Lipocalin/cytosolic fatty-acid binding domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SW44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44", "locus": {} } ], "crossref": [ { "id": "A0AAA9SW44", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW44", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SW44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVLLLSVVLGLLYAGHGEAQLILKPFSGEWKTHYIAASNKDKITEGGPFHAYVRHLEFHANNTVDLDFYVKSDGECVKKQLTGERQQLLVYHVEYAGENEVTILHLSPDAIIGSIHNVDEEGKETDLVGVLSKRDQISDLVYQKFKKETEDKGIPEENIVNFSDNDDCPEE", "length": 172, "header": "tr|A0AAA9SW44-1|A0AAA9SW44_BOVIN Isoform 1 of Lipocalin/cytosolic fatty-acid binding domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SW44-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44/entry#A0AAA9SW44-1", "sequence": { "sequence": "MKVLLLSVVLGLLYAGHGEAQLILKPFSGEWKTHYIAASNKDKITEGGPFHAYVRHLEFHANNTVDLDFYVKSDGECVKKQLTGERQQLLVYHVEYAGENEVTILHLSPDAIIGSIHNVDEEGKETDLVGVLSKRDQISDLVYQKFKKETEDKGIPEENIVNFSDNDDCPEE", "length": 172, "header": "tr|A0AAA9SW44-1|A0AAA9SW44_BOVIN Isoform 1 of Lipocalin/cytosolic fatty-acid binding domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SW44-1" }, "locus": { "chromosome": "X", "start_pos": 137438754, "end_pos": 137429472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075067.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075067.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088236.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088236.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small molecule binding", "id": "GO:0036094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SW44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW44" }, { "id": "PF00061", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipocalin/cytosolic fatty-acid binding", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 166, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW45-1", "uniprot_ac": "A0AAA9SW45", "uniprot_id": "A0AAA9SW45_BOVIN", "mass": { "chemical_mass": 118233.0, "monoisotopic_mass": 118233.0 }, "refseq": { "ac": "XP_002685082", "name": "U2 snRNP-associated SURP motif-containing protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685082" }, "gene_names": [ { "name": "U2SURP", "type": "recommended", "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ] }, { "name": "U2SURP", "type": "synonym", "evidence": [ { "id": "XP_002685082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685082" } ] } ], "protein_names": [ { "name": "U2 snRNP-associated SURP motif-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45/entry#names_and_taxonomy" } ] }, { "name": "140 kDa Ser/Arg-rich domain protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45/entry#names_and_taxonomy" } ] }, { "name": "U2 snRNP-associated SURP motif-containing protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002685082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685082" } ] }, { "name": "U2-associated protein SR140", "type": "synonym", "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "U2SURP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45", "locus": { "chromosome": "1", "start_pos": 125936272, "end_pos": 125986606, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009154", "url": "https://www.ensembl.org/id/ENSBTAG00000009154" } ] } } ], "crossref": [ { "id": "A0AAA9SW45", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW45", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009154", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009154", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21370", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21370", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505019", "url": "https://www.ncbi.nlm.nih.gov/gene/505019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505019", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MHP1", "url": "https://www.orthodb.org/?gene=F1MHP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23140:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23140:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04818", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04818", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08312", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08312", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685082", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685082", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHP1", "url": "https://www.uniprot.org/uniprotkb/F1MHP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHP1-1", "url": "https://www.uniprot.org/uniprotkb/F1MHP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESARENVSDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKEAEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKAGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH", "length": 1029, "header": "tr|A0AAA9SW45-1|A0AAA9SW45_BOVIN Isoform 1 of U2 snRNP-associated SURP motif-containing protein OS=Bos taurus OX=9913 GN=U2SURP PE=3 SV=1 CANONICAL=A0AAA9SW45-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45/entry#A0AAA9SW45-1", "sequence": { "sequence": "MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESARENVSDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKEAEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKAGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH", "length": 1029, "header": "tr|A0AAA9SW45-1|A0AAA9SW45_BOVIN Isoform 1 of U2 snRNP-associated SURP motif-containing protein OS=Bos taurus OX=9913 GN=U2SURP PE=3 SV=1 CANONICAL=A0AAA9SW45-1" }, "locus": { "chromosome": "1", "start_pos": 125986585, "end_pos": 125937276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088655.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088655.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087439.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087439.1" } ] } }, { "isoform_ac": "F1MHP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45/entry#F1MHP1-1", "sequence": { "sequence": "MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESARENVSDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKEAEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKAGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH", "length": 970, "header": "tr|F1MHP1-1|A0AAA9SW45_BOVIN Computationally mapped isoform of U2 snRNP-associated SURP motif-containing protein OS=Bos taurus OX=9913 GN=U2SURP PE=3 SV=3 CANONICAL=A0AAA9SW45-1" }, "locus": { "chromosome": "1", "start_pos": 125986585, "end_pos": 125937276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012063.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012063.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012063.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012063.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505019", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505019", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ], "pmid": "" }, { "name": "U2 snRNP", "id": "GO:0005686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005686", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "RNA processing", "id": "GO:0006396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 499, "end_pos": 501, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" }, { "id": "PS51391", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51391" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CID", "eco_id": "ECO_0000259", "start_pos": 534, "end_pos": 679, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 274, "end_pos": 355, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW45" }, { "id": "PS50128", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SURP motif", "eco_id": "ECO_0000259", "start_pos": 430, "end_pos": 473, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 499, "end_pos": 501 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 611, "end_pos": 613 }, { "start_pos": 631, "end_pos": 633 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SW74-1", "uniprot_ac": "A0AAA9SW74", "uniprot_id": "A0AAA9SW74_BOVIN", "mass": { "chemical_mass": 59290.0, "monoisotopic_mass": 59290.0 }, "refseq": {}, "gene_names": [ { "name": "SNTA1", "type": "recommended", "evidence": [ { "id": "A0AAA9SW74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ] } ], "protein_names": [ { "name": "Alpha-1-syntrophin", "type": "recommended", "evidence": [ { "id": "A0AAA9SW74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNTA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74", "locus": { "chromosome": "13", "start_pos": 62888941, "end_pos": 62915182, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000512", "url": "https://www.ensembl.org/id/ENSBTAG00000000512" } ] } } ], "crossref": [ { "id": "A0AAA9SW74", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SW74", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01258", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01258", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06801", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06801", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10554", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10554", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10554:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10554:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHF8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YHF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGRRAPRTGLLELRAGAGSGAGGERWQRAVLSLEEDALTVSPADGEPGPEPGAQREPEPAQLNGAAEPGAASPPLPEALLLQPRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKEVSPYFKNSASGTSVGWDSPPASPLQRQPSSPGPPPRDLRDAKHMSLKMAYVSRRCTPTDPETRYLEICSADGRDTLFLRAKDEASAKSWAAAIQAQVNTLTPRVKDELQALLSATSTAGSQDIKRIGWLTEQLPSGGTAPTLALLTEKELLLYSCLPQTREALSRPARTAPLITTRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTGGLGGYGSAFLVMSCLSPGAFVSFFRMLQEGDQEWDLGSPRALCFGCAGVLEACTWNGRACSLSVHIDNGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA", "length": 557, "header": "tr|A0AAA9SW74-1|A0AAA9SW74_BOVIN Isoform 1 of Alpha-1-syntrophin OS=Bos taurus OX=9913 GN=SNTA1 PE=3 SV=1 CANONICAL=A0AAA9SW74-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SW74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74/entry#A0AAA9SW74-1", "sequence": { "sequence": "MASGRRAPRTGLLELRAGAGSGAGGERWQRAVLSLEEDALTVSPADGEPGPEPGAQREPEPAQLNGAAEPGAASPPLPEALLLQPRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKEVSPYFKNSASGTSVGWDSPPASPLQRQPSSPGPPPRDLRDAKHMSLKMAYVSRRCTPTDPETRYLEICSADGRDTLFLRAKDEASAKSWAAAIQAQVNTLTPRVKDELQALLSATSTAGSQDIKRIGWLTEQLPSGGTAPTLALLTEKELLLYSCLPQTREALSRPARTAPLITTRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTGGLGGYGSAFLVMSCLSPGAFVSFFRMLQEGDQEWDLGSPRALCFGCAGVLEACTWNGRACSLSVHIDNGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA", "length": 557, "header": "tr|A0AAA9SW74-1|A0AAA9SW74_BOVIN Isoform 1 of Alpha-1-syntrophin OS=Bos taurus OX=9913 GN=SNTA1 PE=3 SV=1 CANONICAL=A0AAA9SW74-1" }, "locus": { "chromosome": "13", "start_pos": 62915172, "end_pos": 62889435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108002.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108002.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087474.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087474.1" } ] } }, { "isoform_ac": "A0AAF6YHF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74/entry#A0AAF6YHF8-1", "sequence": { "sequence": "MASGRRAPRTGLLELRAGAGSGAGGERWQRAVLSLEEDALTVSPADGEPGPEPGAQREPEPAQLNGAAEPGAASPPLPEALLLQPRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKEVSPYFKNSASGTSVGWDSPPASPLQRQPSSPGPPPRDLRDAKHMSLKMAYVSRRCTPTDPETRYLEICSADGRDTLFLRAKDEASAKSWAAAIQAQVNTLTPRVKDELQALLSATSTAGSQDIKRIGWLTEQLPSGGTAPTLALLTEKELLLYSCLPQTREALSRPARTAPLITTRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGAFVSFFRMLQEGDQEWDLGSPRALCFGCAGVLEACTWNGRACSLSVHIDNGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA", "length": 532, "header": "tr|A0AAF6YHF8-1|A0AAF6YHF8_BOVIN Computationally mapped isoform of Alpha-1-syntrophin OS=Bos taurus OX=9913 GN=SNTA1 PE=3 SV=1 CANONICAL=A0AAA9SW74-1" }, "locus": { "chromosome": "13", "start_pos": 62915172, "end_pos": 62889435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000662.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000662.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000662.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000662.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 89, "start_aa": "Thr", "end_pos": 89, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "sodium channel regulator activity", "id": "GO:0017080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "nitric-oxide synthase binding", "id": "GO:0050998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050998", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "anchoring junction", "id": "GO:0070161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of ventricular cardiac muscle cell membrane repolarization", "id": "GO:0060307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "regulation of heart rate", "id": "GO:0002027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "ventricular cardiac muscle cell action potential", "id": "GO:0086005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" }, { "name": "regulation of sodium ion transmembrane transport", "id": "GO:1902305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902305", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SW74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SW74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 170, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SW74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW74" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 269, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 89 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWA0-1", "uniprot_ac": "A0AAA9SWA0", "uniprot_id": "A0AAA9SWA0_BOVIN", "mass": { "chemical_mass": 57500.0, "monoisotopic_mass": 57500.0 }, "refseq": {}, "gene_names": [ { "name": "LOC511936", "type": "recommended", "evidence": [ { "id": "A0AAA9SWA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0" } ] } ], "protein_names": [ { "name": "Cytochrome P450 2J2-like", "type": "recommended", "evidence": [ { "id": "A0AAA9SWA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC511936", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SWA0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051542", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051542", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511936", "url": "https://www.ncbi.nlm.nih.gov/gene/511936", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511936", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511936", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:530929", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530929", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LVTKGMH", "url": "https://omabrowser.org/oma/group/LVTKGMH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MTI6", "url": "https://www.orthodb.org/?gene=F1MTI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTI6", "url": "https://www.uniprot.org/uniprotkb/F1MTI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTI6-1", "url": "https://www.uniprot.org/uniprotkb/F1MTI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEALGSLAAALWAALRPGTVLLGAVVFLFLDDFLKRRRPKNYPPGPPPLPFVGNFFQLDFDKAHLSLQRFVKKYGNVFSVDFGIFRSVLITGLPLIKEALVHQDQNFANRPLIPIEKRIFNNKGLIMSNGHVWKEQRRFALTTLRNFGLGKKSLEERIQEEAAYLIQEIGEENGQPFDPHFTINNAVSNIICSITFGERFDYQDDQFQELLRLFDEMMHLRTSTCCQLYNIFPRIMSFLPGPQHALFSKWEKLKMFIAGVVENHKRDWNPAEARDFIDAYLQEIEKHKGNATSCFHEENLIYNTLDLFFAGTETTSTTLQWGLLYMALYPEIQEKVQAEIDRVLGQSQKPSMAARESMPYTNAVIHEVLRMGNIIPLNVPREVAVDTTLAGYHLPKGTVVVTNLTALHRDPAEWATPDTFNPEHFLENGQFKKRESFLPFSIGKRMCLGEQLARAELFIFFTSLLQKFTFRPPENEKLSLKFRVSLTLAPVSHRLCAVPRG", "length": 502, "header": "tr|A0AAA9SWA0-1|A0AAA9SWA0_BOVIN Isoform 1 of Cytochrome P450 2J2-like OS=Bos taurus OX=9913 GN=LOC511936 PE=3 SV=1 CANONICAL=A0AAA9SWA0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0/entry#A0AAA9SWA0-1", "sequence": { "sequence": "MLEALGSLAAALWAALRPGTVLLGAVVFLFLDDFLKRRRPKNYPPGPPPLPFVGNFFQLDFDKAHLSLQRFVKKYGNVFSVDFGIFRSVLITGLPLIKEALVHQDQNFANRPLIPIEKRIFNNKGLIMSNGHVWKEQRRFALTTLRNFGLGKKSLEERIQEEAAYLIQEIGEENGQPFDPHFTINNAVSNIICSITFGERFDYQDDQFQELLRLFDEMMHLRTSTCCQLYNIFPRIMSFLPGPQHALFSKWEKLKMFIAGVVENHKRDWNPAEARDFIDAYLQEIEKHKGNATSCFHEENLIYNTLDLFFAGTETTSTTLQWGLLYMALYPEIQEKVQAEIDRVLGQSQKPSMAARESMPYTNAVIHEVLRMGNIIPLNVPREVAVDTTLAGYHLPKGTVVVTNLTALHRDPAEWATPDTFNPEHFLENGQFKKRESFLPFSIGKRMCLGEQLARAELFIFFTSLLQKFTFRPPENEKLSLKFRVSLTLAPVSHRLCAVPRG", "length": 502, "header": "tr|A0AAA9SWA0-1|A0AAA9SWA0_BOVIN Isoform 1 of Cytochrome P450 2J2-like OS=Bos taurus OX=9913 GN=LOC511936 PE=3 SV=1 CANONICAL=A0AAA9SWA0-1" }, "locus": { "chromosome": "3", "start_pos": 86038580, "end_pos": 85970252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095196.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095196.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089606.1" } ] } }, { "isoform_ac": "F1MTI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0/entry#F1MTI6-1", "sequence": { "sequence": "MLEALGSLAAALWAALRPGTVLLGAVVFLFLDDFLKRRRPKNYPPGPPPLPFVGNFFQLDFDKAHLSLQRFVKKYGNVFSVDFGIFRSVLITGLPLIKEALVHQDQNFANRPLIPIEKRIFNNKGLIMSNGHVWKEQRRFALTTLRNFGLGKKSLEERIQEEAAYLIQEIGEENGQPFDPHFTINNAVSNIICSITFGERFDYQDDQFQELLRLFDEMMHLRTSTCCQLYNIFPRIMSFLPGPQHALFSKWEKLKMFIAGVVENHKRDWNPAEARDFIDAYLQEIEKHKGNATSCFHEENLIYNTLDLFFAGTETTSTTLQWGLLYMALYPEIQEKVQAEIDRVLGQSQKPSMAARESMPYTNAVIHEVLRMGNILPLNVPREVTVDTVLAGYRLPKGTMVTTNLTALHRDPAEWATPDTFNPEHFLENGQFKKRESFLPFSIGKRMCLGEQLARTELFIFFTSLLQKFTFRPPENEKLSLKFRMSMTLSPLSHRLCAIPRA", "length": 502, "header": "tr|F1MTI6-1|F1MTI6_BOVIN Computationally mapped isoform of Cytochrome P450 2J2-like OS=Bos taurus OX=9913 GN=LOC511936 PE=3 SV=5 CANONICAL=A0AAA9SWA0-1" }, "locus": { "chromosome": "3", "start_pos": 85990920, "end_pos": 85970252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013230.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013230.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013230.8", "url": "https://www.ensembl.org/id/ENSBTAP00000013230.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511936", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511936", "resource": "KEGG Pathway" }, { "id": "bta:530929", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530929", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MN28-1", "protein_name": "Cytochrome P450 2J3 isoform X1", "gene_name": "LOC100764471", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLVTKGSLVAAIWAMLHPKTLLLAAFTFLLLINYLKTRRPKNCPPGPWRLPFVGNLFQLDLEQLHLVIQQFVKKYGNLISLDYGNIPSVVITGLPLIKEAFTHMEQNFLKRPITPIRERVFSNNGLIMSYGQTWKEQRRFALITLRNFGLGRKSLEECIQEEAFHLTNAIGEEEGQPFDPHFKITNAVSNIICSITFGERFGYEDGQFQELLRLLDEATCLETSMMCLLYNVFPSIFKYLPGSHQTVFRNWEKLKLFVSRMMDSHRKDWNPVEPRDFIDAYLTEMTKHPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQEKVQAEIDRVIGLRRQPSTADRESMPYTNAVIHEVQRIGNIIPLNVPREVTTDSTLAGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSIGKRACLGEQLARSELFIFFTALMQKFTFKPPVNEKLSLKFRMGLTLNPVSHHICAVPRL", "length": 502 }, "evidence": [ { "id": "A0AAA9SWA0", "url": "https://omabrowser.org/oma/group/A0AAA9SWA0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O54750-1", "protein_name": "Cytochrome P450 2J6", "gene_name": "Cyp2j6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLAATGSLLATIWAALHPRTLLVAAVTFLLLADYFKNRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQPLVKKYGNIFSLNLGDITSVVITGLPLIKEALTQMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERMQEEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIPGSHQKVFRNWEKLKLFVSCMIDDHRKDWNPDEPRDFIDAFLKEMTKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFTFNPPINEKLSPKFRNGLTLSPVSHRICAVPRQ", "length": 501 }, "evidence": [ { "id": "A0AAA9SWA0", "url": "https://omabrowser.org/oma/group/A0AAA9SWA0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P51589-1", "protein_name": "Cytochrome P450 2J2", "gene_name": "CYP2J2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV", "length": 502 }, "evidence": [ { "id": "A0AAA9SWA0", "url": "https://omabrowser.org/oma/group/A0AAA9SWA0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 404, "end_pos": 406, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 }, { "start_pos": 404, "end_pos": 406 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWE4-1", "uniprot_ac": "A0AAA9SWE4", "uniprot_id": "A0AAA9SWE4_BOVIN", "mass": { "chemical_mass": 56299.0, "monoisotopic_mass": 56299.0 }, "refseq": {}, "gene_names": [ { "name": "ANXA11", "type": "recommended", "evidence": [ { "id": "A0AAA9SWE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ] } ], "protein_names": [ { "name": "Annexin", "type": "recommended", "evidence": [ { "id": "A0AAA9SWE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANXA11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4", "locus": { "chromosome": "28", "start_pos": 35161497, "end_pos": 35119329, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020940", "url": "https://www.ensembl.org/id/ENSBTAG00000020940" } ] } } ], "crossref": [ { "id": "A0AAA9SWE4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020940", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020940", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282142", "url": "https://www.ncbi.nlm.nih.gov/gene/282142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282142", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282142", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQQPMTY", "url": "https://omabrowser.org/oma/group/GQQPMTY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MD66", "url": "https://www.orthodb.org/?gene=F1MD66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MUN7", "url": "https://www.orthodb.org/?gene=F1MUN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD66", "url": "https://www.uniprot.org/uniprotkb/F1MD66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD66-1", "url": "https://www.uniprot.org/uniprotkb/F1MD66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUN7", "url": "https://www.uniprot.org/uniprotkb/F1MUN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUN7-1", "url": "https://www.uniprot.org/uniprotkb/F1MUN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESGGVMVLSSHFLAPFIPAQCSQMGRGWRRAWVLGPGGGAWGGAGYPPPTMPPIGLDNVANYAGQFNQDYLSGVAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPSYGMYPPPGGNPPSGMPSYPPYPGAPVPGQPMLPPGQQPPGVYPGQPPMTYPGQSPVPPPGQQPVPSYPGYSGSGTVTPAVSPAQFGNRGTITDASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDAYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRVYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMTLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSEIDLLDIRAEYKRLYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 522, "header": "tr|A0AAA9SWE4-1|A0AAA9SWE4_BOVIN Isoform 1 of Annexin OS=Bos taurus OX=9913 GN=ANXA11 PE=3 SV=1 CANONICAL=A0AAA9SWE4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4/entry#A0AAA9SWE4-1", "sequence": { "sequence": "MESGGVMVLSSHFLAPFIPAQCSQMGRGWRRAWVLGPGGGAWGGAGYPPPTMPPIGLDNVANYAGQFNQDYLSGVAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPSYGMYPPPGGNPPSGMPSYPPYPGAPVPGQPMLPPGQQPPGVYPGQPPMTYPGQSPVPPPGQQPVPSYPGYSGSGTVTPAVSPAQFGNRGTITDASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDAYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRVYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMTLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSEIDLLDIRAEYKRLYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 522, "header": "tr|A0AAA9SWE4-1|A0AAA9SWE4_BOVIN Isoform 1 of Annexin OS=Bos taurus OX=9913 GN=ANXA11 PE=3 SV=1 CANONICAL=A0AAA9SWE4-1" }, "locus": { "chromosome": "28", "start_pos": 35160774, "end_pos": 35144968, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104790.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104790.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088540.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088540.1" } ] } }, { "isoform_ac": "F1MD66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4/entry#F1MD66-1", "sequence": { "sequence": "MSYPGYPPPAGGYPPGAPGVPELESHAGGPQGLFAAMDRAVSDGPAMMLAAVLLVRATAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPSYGMYPPPGGNPPSGMPSYPPYPGAPVPGQPMLPPGQQPPGVYPGQPPMTYPGQSPVPPPGQQPVPSYPGYSGSGTVTPAVSPAQFGNRGTITDASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDAYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRVYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMTLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSEIDLLDIRAEYKRLYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 505, "header": "tr|F1MD66-1|F1MD66_BOVIN Computationally mapped isoform of Annexin OS=Bos taurus OX=9913 GN=ANXA11 PE=3 SV=3 CANONICAL=A0AAA9SWE4-1" }, "locus": { "chromosome": "28", "start_pos": 35160774, "end_pos": 35144856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027893.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027893.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027893.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027893.6" } ] } }, { "isoform_ac": "F1MUN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4/entry#F1MUN7-1", "sequence": { "sequence": "MDWVLLSGGGAWGGAGYPPPTMPPIGLDNVANYAGQFNQDYLSGVAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPSYGMYPPPGGNPPSGMPSYPPYPGAPVPGQPMLPPGQQPPGVYPGQPPMTYPGQSPVPPPGQQPVPSYPGYSGSGTVTPAVSPAQFGNRGTITDASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDAYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRVYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMTLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSEIDLLDIRAEYKRLYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 492, "header": "tr|F1MUN7-1|F1MUN7_BOVIN Computationally mapped isoform of Annexin OS=Bos taurus OX=9913 GN=ANXA11 PE=3 SV=5 CANONICAL=A0AAA9SWE4-1" }, "locus": { "chromosome": "28", "start_pos": 35160774, "end_pos": 35146342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054137.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054137.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049065.5", "url": "https://www.ensembl.org/id/ENSBTAP00000049065.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 51, "start_aa": "Thr", "end_pos": 51, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr51", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:282142", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282142", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y3W6-1", "protein_name": "Annexin", "gene_name": "ANXA11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDRRKDSTVSMKSVLSASFSDLVLLQMIPFQSPPTPLIKGFVMSHPGYPPAGGYPPAAPGGSPWGGAAYPPSNPPPIGLENVAGYANQFNPSYMAGMASNMAGTFGGSNVPQGIYPSAPGGYPPVPAGGFGQPPPGQQPSYGGYPPSGGNAPGFPGGPALGQPTLPPGQPPMGLPGQPPAPYPGQQPMPTYPPVPAVNPSMPSYPGPTGPTVSPGAYGNRGTITDALGFDPLKDAEVLRKAMKGLGTDEQAIIDCLGSRSNKQRQQIILSFKTAYGKDLIKDLKSELSGNFEKTILAMMKTPVMFDAYEIKEAIKGIGTDENCLIEILASRSNEHIQELNRVYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLVQKDVQELYAAGENRLGTDESKFNAILCARSRAHLRAVFSEYQRMCNRDIENSICREMSGDLEKGMLAVVKCLKNTPAFFAERLRNAMKGAGTKDRTLIRIMVSRSEVDLLDIRAEYKRMYGKSLYADITGDTSGDYRKILLKLCGGND", "length": 534 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B8A4V2-1", "protein_name": "Annexin", "gene_name": "anxa11a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSYPGYPPQSGYPPQGGGYPPQPGAYPPAAGGYPPQPGMYPPQAGGYPPQPGAYPPQPGAFPGQPGQYPSVPSGGWGAPIGLDNLPNPGFNASNIQGMANQFAADGGFAPNPSMFSGGYPGPQPGGPPAVSPNQPYGMYLQPGGGMPQNPGMGYPGGPPPGQQMPSYPNIPAPTPSGPSYPRAPSPNPSMPGYGGGYGGGAPAVPAISRGFRGSIQDFPGADPLRDAEVLRKAMKGFGTDEQAIINLLGSRSNKQRVPLLVSYKTAYGKDLIKDLKSELSGNFEKLVLAMLKTPSQYDAYELKEAIKGAGTDEACLIEILASRSNAEIREINQVFKAENKKSLEDAISGDTSGHFRRLLVSLAQGNRDESENVDISIAKTDAQALYQAGENKLGTDESKFNAILCARSKAHLRAVFNEYQHMCGRDIEKSIEREMSGDLESGMLAVVKCIKNTPAYFAERLHKAMKGAGTKDRTLIRIMVTRSEVDMLDIRQEYAKNYGKSLYTAISGDTSGDYKKLLLKLCGGSD", "length": 526 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S2E2-1", "protein_name": "Annexin", "gene_name": "ANXA11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSYPGYPPPTGGYPPAAPGGAWGGAAYPPPSMPPIGLDNVANYAGQFNQDYLSGMAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSGMPTYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPMPYAGQSPMPPPGQQPMPSYPGYSGSGTVTPAVPPAQFGNRGTIADAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPILFDAYEIKEAIKGAGTDEACLIEILASRSNEHIRELSRAYKTEFKKTLEDAIRSDTSGHFQRLLISLSQGNRDESTNVDMALVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSEIDLLDIRAEYKRLYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 502 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7FLB7-1", "protein_name": "Annexin", "gene_name": "Anxa11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGARLCSTGKAQGFLQEVTTKSAALTCGRGHTHPAPPERPRPAPLLWLRPGESKAAAPGEFSALRAPPPTVRRHSRVEIRKARLGGSCYPSSVSRSLVPALPMSYPGYPPPAGGYPPGAPGGAPWGGASYPPPSMPPIGLDNVANYAGQFNQDYLSGMAANMSGTFGGANVPNMYPGAPGGGYPPVPPGGFGQPPPAQQPVPPYGMYPPPGGNPPPGMPSYPAYPGAPVPGQPMPPPGQQPPGAYPGQPPMTYPGQSPMPPPGQQPVPSYPGYSGSSTITPAVPPAQFGNRGTITDASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDVYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRAYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSELDLLDIRAEYKRMYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 606 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HHA9-1", "protein_name": "Annexin", "gene_name": "Anxa11", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSYPGYPPPAGGYPPAAPGGGPWGGAGYPPPSMPPIGLDNVANYAGQFNQDYLSGMATNMSGTFGGANMPNLYPGAPGGAYPPVPPGGFGQPPPAQQPVPPYGMYPPPGGNPPPGMPSYPAYPGAPVPGQPMPPPGQQPPGAYPGQPPMTYPGQSPMPPPGQQPVPSYPGYSGSSTVTPAVPPAQFGNRGTITDASGFDPMRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDVYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRAYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNDYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSELDLLDIRAEYKRMYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 503 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P50995-1", "protein_name": "Annexin A11", "gene_name": "ANXA11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND", "length": 505 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97384-1", "protein_name": "Annexin A11", "gene_name": "Anxa11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYPGYPPPAGGYPPAAPGGGPWGGAGYPPPSMPPIGLDNVANYAGQFNQDYLSGMAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPPYGMYPPPGGNPPPGMPSYPAYPGAPVPGQPMPPTGQQPPGAYPGQPPMTYPGQSPMPPPGQQPVPSYPGYSGSSTITPAVPPAQFGNRGTITAASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDVYEIKEAIKGAGTDEACLIEIFASRSNEHIRELSRAYKTEFQKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSELDLLDIRAEYKRMYGKSLYHDITGDTSGDYRKILLKICGGND", "length": 503 }, "evidence": [ { "id": "A0AAA9SWE4", "url": "https://omabrowser.org/oma/group/A0AAA9SWE4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "phosphatidylethanolamine binding", "id": "GO:0008429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "chromaffin granule membrane", "id": "GO:0042584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042584", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "vesicle membrane", "id": "GO:0012506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" }, { "name": "cytokinetic process", "id": "GO:0032506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 51 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWH0-1", "uniprot_ac": "A0AAA9SWH0", "uniprot_id": "A0AAA9SWH0_BOVIN", "mass": { "chemical_mass": 10748.0, "monoisotopic_mass": 10748.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Protein FAM24A", "type": "recommended", "evidence": [ { "id": "A0AAA9SWH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0", "locus": {} } ], "crossref": [ { "id": "A0AAA9SWH0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR028122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR35860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35860:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35860:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VEMFDLEIMIAIGSALLITAFVLIGVVIGLYYKVANTLNAAKTPIATTITCSDQDKVTEAATSTPESYPSFQCCEECNLPANFDPLTSCFCDINKGLNTE", "length": 100, "header": "tr|A0AAA9SWH0-1|A0AAA9SWH0_BOVIN Isoform 1 of Protein FAM24A OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SWH0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0/entry#A0AAA9SWH0-1", "sequence": { "sequence": "VEMFDLEIMIAIGSALLITAFVLIGVVIGLYYKVANTLNAAKTPIATTITCSDQDKVTEAATSTPESYPSFQCCEECNLPANFDPLTSCFCDINKGLNTE", "length": 100, "header": "tr|A0AAA9SWH0-1|A0AAA9SWH0_BOVIN Isoform 1 of Protein FAM24A OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SWH0-1" }, "locus": { "chromosome": "26", "start_pos": 42732238, "end_pos": 42730813, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087825.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087825.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088395.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088395.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWH8-1", "uniprot_ac": "A0AAA9SWH8", "uniprot_id": "A0AAA9SWH8_BOVIN", "mass": { "chemical_mass": 24662.0, "monoisotopic_mass": 24662.0 }, "refseq": { "ac": "XP_010799221", "name": "claudin-17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799221" }, "gene_names": [ { "name": "CLDN17", "type": "recommended", "evidence": [ { "id": "A0AAA9SWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ] }, { "name": "CLDN17", "type": "synonym", "evidence": [ { "id": "XP_010799221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799221" } ] } ], "protein_names": [ { "name": "Claudin", "type": "recommended", "evidence": [ { "id": "A0AAA9SWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8/entry#names_and_taxonomy" } ] }, { "name": "claudin-17", "type": "synonym", "evidence": [ { "id": "XP_010799221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799221" } ] } ], "function": [ { "annotation": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8#function" }, { "database": "UniProtKB", "id": "RU060637", "url": "https://www.uniprot.org/uniprotkb/RU060637#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLDN17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8", "locus": { "chromosome": "1", "start_pos": 5832034, "end_pos": 5829939, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061152", "url": "https://www.ensembl.org/id/ENSBTAG00000061152" } ] } } ], "crossref": [ { "id": "A0AAA9SWH8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "512703", "url": "https://www.ncbi.nlm.nih.gov/gene/512703", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512703", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512703", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VCWTANI", "url": "https://omabrowser.org/oma/group/VCWTANI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010799221", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799221", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFYPLQIAGLVLGFFGMIGTLTTTLLPQWRVSAFIGSNIIVFERVWEGLWMNCVRQAKDKLQCKVYDSLLALPPALEAARALMCVAVALSVIALLVGICGMKKIQCTGSNRRAKAYLVGISGVLFILTGIFVLIPVCWMANNIIRDFYNPAVHVGQKRELGASLFVGWATTAVLIIGGVLLCGFCCCNRNRPRHRYLAPGHRVPHARNPPRPVAVLSRTSTSYV", "length": 225, "header": "tr|A0AAA9SWH8-1|A0AAA9SWH8_BOVIN Isoform 1 of Claudin OS=Bos taurus OX=9913 GN=CLDN17 PE=3 SV=1 CANONICAL=A0AAA9SWH8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8/entry#A0AAA9SWH8-1", "sequence": { "sequence": "MAFYPLQIAGLVLGFFGMIGTLTTTLLPQWRVSAFIGSNIIVFERVWEGLWMNCVRQAKDKLQCKVYDSLLALPPALEAARALMCVAVALSVIALLVGICGMKKIQCTGSNRRAKAYLVGISGVLFILTGIFVLIPVCWMANNIIRDFYNPAVHVGQKRELGASLFVGWATTAVLIIGGVLLCGFCCCNRNRPRHRYLAPGHRVPHARNPPRPVAVLSRTSTSYV", "length": 225, "header": "tr|A0AAA9SWH8-1|A0AAA9SWH8_BOVIN Isoform 1 of Claudin OS=Bos taurus OX=9913 GN=CLDN17 PE=3 SV=1 CANONICAL=A0AAA9SWH8-1" }, "locus": { "chromosome": "1", "start_pos": 5830794, "end_pos": 5830120, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098861.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098861.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089675.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089675.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512703", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512703", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LEW6-1", "protein_name": "Claudin", "gene_name": "Cldn17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAFYPLQIAGLVLGFFGMVGTIGTTLLPQWRVSAFIGSNIIIFERIWEGLWMNCIQQARVTLQCKFYTSILALPPVLEAARALMCVAIALSLVALIIGICGMKQVQCTGSSERVKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYDPNIHVGQKRELGGALFLGWATVAVLFIAGGLLCGYFCCNRKKQWHRYPVPAYRVPQKDNQRKGAVPSKTSTSYV", "length": 224 }, "evidence": [ { "id": "A0AAA9SWH8", "url": "https://omabrowser.org/oma/group/A0AAA9SWH8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YAI2-1", "protein_name": "Claudin", "gene_name": "LOC427973", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MACCALQIIGLIFGGVGMVGTLAATAMPQWRVSAHIDSNIVVFETIWEGLWMDCISQMGIRLQCKFYDSILALPPPLEAFRALMCIAVLLSIIAFLMAIVGVKYTHWTKEDPQGISIFMLAAGVAFLLTGILVLIPVSWTGGSIVHDFYDAKVPTPLKRELGAALYVGWVSAALLIIAGAMYCSFWCWAGTTPKSRDPSLPPHRLHRPNTAGGPLLSMQAYV", "length": 222 }, "evidence": [ { "id": "A0AAA9SWH8", "url": "https://omabrowser.org/oma/group/A0AAA9SWH8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "C3VMW3-1", "protein_name": "Claudin-17", "gene_name": "CLDN17", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFIGSNIIVFERIWEGLWMNCVRQAKARLQCKFYSSMLALSPALEAARALMCVAVALSLIALIIGICGMKKIQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVCWTANIIIRDFYNPAVHVGQKRELGAALFLGWASVAVLFIAGGLLCGFCCCNRKKQRDGYPAPRPSMPRTDERRRNMTRQSETPTSYV", "length": 225 }, "evidence": [ { "id": "A0AAA9SWH8", "url": "https://omabrowser.org/oma/group/A0AAA9SWH8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P56750-1", "protein_name": "Claudin-17", "gene_name": "CLDN17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV", "length": 224 }, "evidence": [ { "id": "A0AAA9SWH8", "url": "https://omabrowser.org/oma/group/A0AAA9SWH8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BXA6-1", "protein_name": "Claudin-17", "gene_name": "Cldn17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFYPLQIAGLVLGFFGLVGTIGTTLLPQWRVSAFIGSNIIIFERIWEGLWMNCIQQAMVTLQCKFYNSILALPPVLEAARALMCVAVALALVALIIGICGMKQLQCTGSSERVKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYDPTVHAGQKRELGGALFLGWATAAVLFIGGGLLCGYCCCNRKERWHRYPVPAYRVPQKDNQRNVTVPRKSSTSYV", "length": 224 }, "evidence": [ { "id": "A0AAA9SWH8", "url": "https://omabrowser.org/oma/group/A0AAA9SWH8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "pmid": "" }, { "name": "channel activity", "id": "GO:0015267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "pmid": "" }, { "name": "paracellular tight junction channel activity", "id": "GO:0160187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160187", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "paracellular transport", "id": "GO:0160184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWK0-1", "uniprot_ac": "A0AAA9SWK0", "uniprot_id": "A0AAA9SWK0_BOVIN", "mass": { "chemical_mass": 18700.0, "monoisotopic_mass": 18700.0 }, "refseq": {}, "gene_names": [ { "name": "C8orf90", "type": "recommended", "evidence": [ { "id": "A0AAA9SWK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0" } ] } ], "protein_names": [ { "name": "Chromosome 8 open reading frame 90", "type": "synonym", "evidence": [ { "id": "A0AAA9SWK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C8orf90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0", "locus": { "chromosome": "14", "start_pos": 2479293, "end_pos": 2484362, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000070093", "url": "https://www.ensembl.org/id/ENSBTAG00000070093" } ] } } ], "crossref": [ { "id": "A0AAA9SWK0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWK0", "database": "AlphaFoldDB", "categories": [] }, { "id": "A0AAA9SWK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Q0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPCSGDPSPAGLPPCPVATPGPAAPQEHPFPDIYGGDAQLWEAHFRGIGRAYRALGKEDDFAIRVLTEDFTLPFPFAWPPGPDPARGPLFYDPHDRTGFDFLLRGPGAPPPVLLRPLHSTAQAALRKRRLEQLALSYAHAGAGPRPGLVLLAPVPAAAGSAFPGPEAAAPGGGAPRLG", "length": 180, "header": "tr|A0AAA9SWK0-1|A0AAA9SWK0_BOVIN Isoform 1 of Chromosome 8 open reading frame 90 OS=Bos taurus OX=9913 GN=C8orf90 PE=4 SV=2 CANONICAL=A0AAA9SWK0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0/entry#A0AAA9SWK0-1", "sequence": { "sequence": "MASPCSGDPSPAGLPPCPVATPGPAAPQEHPFPDIYGGDAQLWEAHFRGIGRAYRALGKEDDFAIRVLTEDFTLPFPFAWPPGPDPARGPLFYDPHDRTGFDFLLRGPGAPPPVLLRPLHSTAQAALRKRRLEQLALSYAHAGAGPRPGLVLLAPVPAAAGSAFPGPEAAAPGGGAPRLG", "length": 180, "header": "tr|A0AAA9SWK0-1|A0AAA9SWK0_BOVIN Isoform 1 of Chromosome 8 open reading frame 90 OS=Bos taurus OX=9913 GN=C8orf90 PE=4 SV=2 CANONICAL=A0AAA9SWK0-1" }, "locus": { "chromosome": "14", "start_pos": 2484294, "end_pos": 2479326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092109.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092109.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088435.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088435.2" } ] } }, { "isoform_ac": "A0ABI0P0Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWK0/entry#A0ABI0P0Q0-1", "sequence": { "sequence": "MATHSSILAWRIPWTEEPGPAAPQEHPFPDIYGGDAQLWEAHFRGIGRAYRALGKEDDFAIRVLTEDFTLPFPFAWPPGPDPARGPLFYDPHDRTGFDFLLRGPGAPPPVLLRPLHSTAQAALRKRRLEQLALSYAHAGAGPRPGLVLLAPVPAAAGSAFPGPEAAAPGGGAPRLG", "length": 176, "header": "tr|A0ABI0P0Q0-1|A0ABI0P0Q0_BOVIN Computationally mapped isoform of Chromosome 8 open reading frame 90 OS=Bos taurus OX=9913 GN=C8orf90 PE=4 SV=1 CANONICAL=A0AAA9SWK0-1" }, "locus": { "chromosome": "14", "start_pos": 2482480, "end_pos": 2479326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146027.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146027.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106512.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 21, "start_aa": "Thr", "end_pos": 21, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr21", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 21 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU58-1", "uniprot_ac": "A0AAA9SU58", "uniprot_id": "A0AAA9SU58_BOVIN", "mass": { "chemical_mass": 81483.0, "monoisotopic_mass": 81483.0 }, "refseq": { "ac": "XP_024834013", "name": "protein spire homolog 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834013" }, "gene_names": [ { "name": "SPIRE2", "type": "recommended", "evidence": [ { "id": "A0AAA9SU58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ] }, { "name": "SPIRE2", "type": "synonym", "evidence": [ { "id": "XP_024834013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834013" } ] } ], "protein_names": [ { "name": "Spire type actin nucleation factor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SU58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58/entry#names_and_taxonomy" } ] }, { "name": "protein spire homolog 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024834013", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834013" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPIRE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58", "locus": { "chromosome": "18", "start_pos": 14679679, "end_pos": 14652352, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040356", "url": "https://www.ensembl.org/id/ENSBTAG00000040356" } ] } } ], "crossref": [ { "id": "A0AAA9SU58", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU58", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22065", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22065", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22079", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22079", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22081", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22081", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22186", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22186", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518761", "url": "https://www.ncbi.nlm.nih.gov/gene/518761", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21345:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21345:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16474", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16474", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834013", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834013", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARAGSSSGDAAAGERAGGAGRSEPWELSLEEVLKAYEQPINEEQAWAVCFQCCRGLRGAPGGRRRIRDTADILLRRDGSVSARRESGAAEPTTMVSPASSEAQVVQSLGFAIYRALDWGLAEHEERELSPQLERLIDLMANSDCDDDGGGGTADEGYGGPEEEEEAEGGPRTVRTFAQAMRLCAARLTEPRGAQTHYQAVCRALFVETLELRAFLARVREAKEMLQRFREDEPQAEKPLVELDSLRRTDWARLWVQLMRELRHGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPQKQRTLHEKILEEIKQERRLRPVESRRWDGRGERGFGSLPCILNACSGDVKSTSCINLSITDVGSSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEGTLKRDRSFSEHDLVQLRSEVTSGLQPAPQPPGGLELSRPRAGSMQSWRPSPLEPGSLPVSVQSQPDPSSLPRSDMSSVEDRQGASAAPDASHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLLSWPPSCLFCKRAVCNSCSIKMKMPSKKFAHIPVYTLGFESPQRMSTAKTTPTQRRDAFQCVLPLIPARAAVAERGGGVPAHVHPRLCHEGRVQRLHRVRGGCGALQPQERGGPQHHATSCPPDPVPVCPEHLDT", "length": 731, "header": "tr|A0AAA9SU58-1|A0AAA9SU58_BOVIN Isoform 1 of Spire type actin nucleation factor 2 OS=Bos taurus OX=9913 GN=SPIRE2 PE=3 SV=1 CANONICAL=A0AAA9SU58-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58/entry#A0AAA9SU58-1", "sequence": { "sequence": "MARAGSSSGDAAAGERAGGAGRSEPWELSLEEVLKAYEQPINEEQAWAVCFQCCRGLRGAPGGRRRIRDTADILLRRDGSVSARRESGAAEPTTMVSPASSEAQVVQSLGFAIYRALDWGLAEHEERELSPQLERLIDLMANSDCDDDGGGGTADEGYGGPEEEEEAEGGPRTVRTFAQAMRLCAARLTEPRGAQTHYQAVCRALFVETLELRAFLARVREAKEMLQRFREDEPQAEKPLVELDSLRRTDWARLWVQLMRELRHGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPQKQRTLHEKILEEIKQERRLRPVESRRWDGRGERGFGSLPCILNACSGDVKSTSCINLSITDVGSSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEGTLKRDRSFSEHDLVQLRSEVTSGLQPAPQPPGGLELSRPRAGSMQSWRPSPLEPGSLPVSVQSQPDPSSLPRSDMSSVEDRQGASAAPDASHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLLSWPPSCLFCKRAVCNSCSIKMKMPSKKFAHIPVYTLGFESPQRMSTAKTTPTQRRDAFQCVLPLIPARAAVAERGGGVPAHVHPRLCHEGRVQRLHRVRGGCGALQPQERGGPQHHATSCPPDPVPVCPEHLDT", "length": 731, "header": "tr|A0AAA9SU58-1|A0AAA9SU58_BOVIN Isoform 1 of Spire type actin nucleation factor 2 OS=Bos taurus OX=9913 GN=SPIRE2 PE=3 SV=1 CANONICAL=A0AAA9SU58-1" }, "locus": { "chromosome": "18", "start_pos": 14678675, "end_pos": 14652405, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121186.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121186.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087684.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087684.1" } ] } }, { "isoform_ac": "A0AAA9TWF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58/entry#A0AAA9TWF8-1", "sequence": { "sequence": "MGGEDARETRWLRLAPTSPCISRGLRLSPSLCFSPGSSWFVNKYELVCRMPEPTTMVSPASSEAQVVQSLGFAIYRALDWGLAEHEERELSPQLERLIDLMANSDCDDDGGGGTADEGYGGPEEEEEAEGGPRTVRTFAQAMRLCAARLTEPRGAQTHYQAVCRALFVETLELRAFLARVREAKEMLQRFREDEPQAEKPLVELDSLRRTDWARLWVQLMRELRHGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPQKQRTLHEKILEEIKQERRLRPVESRRWDGRGERGFGSLPCILNACSGDVKSTSCINLSITDVGSSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEGTLKRDRSFSEHDLVQLRSEVTSGLQPAPQPPGGLELSRPRAGSMQSWRPSPLEPGSLPVSVQSQPDPSSLPRSDMSSVEDRQGASAAPDASHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLLSWPPSCLFCKRAVCNSCSIKMKMPSKKFAHIPVYTLGFESPQRMSTAKTTPTQRRDAFQSLQGLQWRNVEEEFPHMYTHGCVMKDVCSDCTGFVADVVHSSRRSVEALNTTPRRARQTQSLYVPNTWTLDLK", "length": 690, "header": "tr|A0AAA9TWF8-1|A0AAA9TWF8_BOVIN Computationally mapped isoform of Spire type actin nucleation factor 2 OS=Bos taurus OX=9913 GN=SPIRE2 PE=3 SV=1 CANONICAL=A0AAA9SU58-1" }, "locus": { "chromosome": "18", "start_pos": 14678685, "end_pos": 14657741, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091611.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091611.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102961.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "actin nucleation", "id": "GO:0045010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "polar body extrusion after meiotic divisions", "id": "GO:0040038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "establishment of meiotic spindle localization", "id": "GO:0051295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051295", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "formin-nucleated actin cable assembly", "id": "GO:0070649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070649", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair", "id": "GO:2000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" }, { "name": "cleavage furrow formation", "id": "GO:0036089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036089", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SU58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU58" }, { "id": "PS51377", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51377" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KIND", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 212, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 402, "end_pos": 404 }, { "start_pos": 433, "end_pos": 435 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SUV4-1", "uniprot_ac": "A0AAA9SUV4", "uniprot_id": "A0AAA9SUV4_BOVIN", "mass": { "chemical_mass": 67925.0, "monoisotopic_mass": 67925.0 }, "refseq": {}, "gene_names": [ { "name": "IL27RA", "type": "recommended", "evidence": [ { "id": "A0AAA9SUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ] } ], "protein_names": [ { "name": "Interleukin-27 receptor subunit alpha", "type": "recommended", "evidence": [ { "id": "A0AAA9SUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4/entry#names_and_taxonomy" } ] }, { "name": "Type I T-cell cytokine receptor", "type": "synonym", "evidence": [ { "id": "A0AAA9SUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL27RA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4", "locus": { "chromosome": "7", "start_pos": 11641168, "end_pos": 11665060, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016933", "url": "https://www.ensembl.org/id/ENSBTAG00000016933" } ] } } ], "crossref": [ { "id": "A0AAA9SUV4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SUV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016933", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016933", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514529", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514529", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCCCSLI", "url": "https://omabrowser.org/oma/group/TCCCSLI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48423:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48423:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28570", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28570", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABZ3NNI5", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABZ3NNI5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGTPAAPFPPRPKPMLLLLLLLLFSRTRPQGSPGPLQCYGVGPLGDLNCSWEPHGDLGAPSMLYVQSQKYHSNKTWTVAVPTGQNWVTIPREQLTMSDELLVWAAKAGQLLWSPVFVNLETRMKPDAPHLYPDVDFSDDHPLEAVVQWAPPTWPPHKVLVCRFYYRRCRMPWVMLEPEVKSIPLMPIEIQDLELATGYEMFGRCQVDKEEDLWGEWSPILPFQTPPSAPKDVWIMGNICGAPGGQEPLLLWKASGLCMQVTYRVWIQVKDQEVIQEETPYCNFSIPTQAEWVGVSAVNATSWELPTNLSLTCLGPDSAPHGVVVRSISGNTELLVTWQQEPGELQEHVVDWIRDGDPVEDLNWVRLPPGNLSAVLPVDFKEGVPYRITVTAISPWGLAPAPSVWKFREELVPLSGPVVWRIQDAPSGTPAVAWGEVPRQQLRGHLTHYTLCTQSGTRPSVCKNDNTLNWKVLSVVFLLWGLLLTGCGVSLATCGRCVHLQHKVLPHWVWEKIPDPANSNFSLPHMKEVPQAQPPGDSPILEVEEIEQVPVKEPPQPLAPLDSGYEKHFLPTPEELGLLSPTAGSRLRPELTSGGERGAPLTDEDIEAQS", "length": 610, "header": "tr|A0AAA9SUV4-1|A0AAA9SUV4_BOVIN Isoform 1 of Interleukin-27 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL27RA PE=3 SV=1 CANONICAL=A0AAA9SUV4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4/entry#A0AAA9SUV4-1", "sequence": { "sequence": "MRGTPAAPFPPRPKPMLLLLLLLLFSRTRPQGSPGPLQCYGVGPLGDLNCSWEPHGDLGAPSMLYVQSQKYHSNKTWTVAVPTGQNWVTIPREQLTMSDELLVWAAKAGQLLWSPVFVNLETRMKPDAPHLYPDVDFSDDHPLEAVVQWAPPTWPPHKVLVCRFYYRRCRMPWVMLEPEVKSIPLMPIEIQDLELATGYEMFGRCQVDKEEDLWGEWSPILPFQTPPSAPKDVWIMGNICGAPGGQEPLLLWKASGLCMQVTYRVWIQVKDQEVIQEETPYCNFSIPTQAEWVGVSAVNATSWELPTNLSLTCLGPDSAPHGVVVRSISGNTELLVTWQQEPGELQEHVVDWIRDGDPVEDLNWVRLPPGNLSAVLPVDFKEGVPYRITVTAISPWGLAPAPSVWKFREELVPLSGPVVWRIQDAPSGTPAVAWGEVPRQQLRGHLTHYTLCTQSGTRPSVCKNDNTLNWKVLSVVFLLWGLLLTGCGVSLATCGRCVHLQHKVLPHWVWEKIPDPANSNFSLPHMKEVPQAQPPGDSPILEVEEIEQVPVKEPPQPLAPLDSGYEKHFLPTPEELGLLSPTAGSRLRPELTSGGERGAPLTDEDIEAQS", "length": 610, "header": "tr|A0AAA9SUV4-1|A0AAA9SUV4_BOVIN Isoform 1 of Interleukin-27 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL27RA PE=3 SV=1 CANONICAL=A0AAA9SUV4-1" }, "locus": { "chromosome": "7", "start_pos": 11664898, "end_pos": 11641624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100905.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100905.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090247.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090247.1" } ] } }, { "isoform_ac": "A0ABZ3NNI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4/entry#A0ABZ3NNI5-1", "sequence": { "sequence": "MRGTPAAPFPPRPKPMLLLLLLLLFSRTRPQGSPGPLQCYGVGPLGDLNCSWEPHGDLGAPSMLYVQSQKYHSNKTWTVAVPTGQNWVTIPREQLTMSDELLVWAAKAGQLLWSPVFVNLETRMKPDAPHLYPDVDFSDDHPLEAVVQWAPPTWPPHKVLVCRFYYRRCRMPWVMLEPEVKSIPLMPIEIQDLELATGYEMFGRCQVDKEEDLWGEWSPILPFQTPPSAPKDVWIMGNICGAPGGQEPLLLWKASGLCMQVTYRVWIQVKDQEVIQEETPYCNFSIPTQAEWVGVSAVNATSWELPTNLSLTCLGPDSAPHGVVVRSISGNTELLVTWQQEPGELQEHVVDWIRDGDPVEDLNWVRLPPGNLSAVLPVDFKEGVPYRITVTAISPWGLAPAPSVWKFREELVPLSGPVVWRIQDAPSGTPAVAWGEVPRQQLRGHLTHYTLCTQSGTRPSVCKNVTGSTRTITLPDLHWGPCKLWMTASTIAGQGPPGPSLQFHLPDNTLNWKVLSVVFLLWGLLLTGCGVSLATCGRCVHLQHKVLPHWVWEKIPDPANSNFSLPHMKETWV", "length": 573, "header": "tr|A0ABZ3NNI5-1|A0ABZ3NNI5_BOVIN Computationally mapped isoform of Interleukin-27 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL27RA PE=3 SV=1 CANONICAL=A0AAA9SUV4-1" }, "locus": { "chromosome": "7", "start_pos": 11664898, "end_pos": 11642060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022524.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022524.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022524.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022524.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 429, "start_aa": "Thr", "end_pos": 429, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr429", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514529", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514529", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of T-helper 17 type immune response", "id": "GO:2000317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000317", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" }, { "name": "negative regulation of interleukin-17 production", "id": "GO:0032700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" }, { "name": "negative regulation of tumor necrosis factor production", "id": "GO:0032720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032720", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" }, { "name": "negative regulation of T cell extravasation", "id": "GO:2000408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000408", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "interleukin-27 receptor activity", "id": "GO:0045509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SUV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV4" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 125, "end_pos": 228, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 429 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 520, "end_pos": 522 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STV0-1", "uniprot_ac": "A0AAA9STV0", "uniprot_id": "A0AAA9STV0_BOVIN", "mass": { "chemical_mass": 110004.0, "monoisotopic_mass": 110004.0 }, "refseq": { "ac": "XP_005221678", "name": "ankycorbin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221678" }, "gene_names": [ { "name": "RAI14", "type": "recommended", "evidence": [ { "id": "A0AAA9STV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ] }, { "name": "RAI14", "type": "synonym", "evidence": [ { "id": "XP_005221678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221678" } ] } ], "protein_names": [ { "name": "Retinoic acid induced 14", "type": "synonym", "evidence": [ { "id": "A0AAA9STV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0/entry#names_and_taxonomy" } ] }, { "name": "ankycorbin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005221678", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221678" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAI14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0", "locus": { "chromosome": "20", "start_pos": 39313837, "end_pos": 39475181, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007071", "url": "https://www.ensembl.org/id/ENSBTAG00000007071" } ] } } ], "crossref": [ { "id": "A0AAA9STV0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007071", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007071", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525869", "url": "https://www.ncbi.nlm.nih.gov/gene/525869", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525869", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525869", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24129:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24129:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221678", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221678", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVC6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVC6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0H4", "url": "https://www.uniprot.org/uniprotkb/F1N0H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0H4-1", "url": "https://www.uniprot.org/uniprotkb/F1N0H4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAATKGHVECLRVMVTHGVDVTAQDTAGHSALHLAAKNSHHECVKKLLQSKCPAESIDSSGKTALHYAAAQGCLQAVQVLCEHRSPINLKDLDGNIPLLLAVQNGHSEVCRFLLDHGADVNSRDKNGRTALMLACEIGSSNIVEALIKKGADLNLVDSLGHNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKQAEISSIRENRDRLSDSTTGADSLLDVSSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKTPREGEADLSFDSYHSTQTDLAPSLGKPSENPPLDSKPSPSVITHSSSKSTLDSDVRIQQLQEVLHDLQKRLESSEAERKQLQAELQTRRTESVCLNNAEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESVDTYSHLHELRITEEEMDVLKRDLQGALEESERNKEKVRELEEKLAEREKEAVIQPPREEYEEMKSSYCTVIENMNKEKAFLFEKYQEAQEEITKLKDTLKNQMTQEAGDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQVTNVSRAKAEEALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTTAKEMEGKISSLKEHLASKEGEVAKLEKQLLEEKAAMTDAMVPRSAYEKLQSSLESEVSVLASKLRDSVKEKEKAHSEVAQIRSEVSQMKREKENIQTLLKSKEQEVNELLQKCQHAQEELAEMKRHSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSASSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK", "length": 981, "header": "tr|A0AAA9STV0-1|A0AAA9STV0_BOVIN Isoform 1 of Retinoic acid induced 14 OS=Bos taurus OX=9913 GN=RAI14 PE=4 SV=1 CANONICAL=A0AAA9STV0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0/entry#A0A3Q1MIZ7-1", "sequence": { "sequence": "MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAATKGHVECLRVMVTHGVDVTAQDTAGHSALHLAAKNSHHECVKKLLQSKCPAESIDSSGKTALHYAAAQGCLQAVQVLCEHRSPINLKDLDGNIPLLLAVQNGHSEVCRFLLDHGADVNSRDKNGRTALMLACEIGSSNIVEALIKKGADLNLVDSLGHNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKQAEISSIRENRDRLSDSTTGADSLLDVSSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKTPREGEADLSFDSYHSTQTDLAPSLGKPSENPPLDSKPSPSVITHSSSKSTLDSDVRIQQLQEVLHDLQKRLESSEAERKQLQAELQTRRTESVCLNNAEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESVDTYSHLHELRITEEEMDVLKRDLQGALEESERNKEKVRELEEKLAEREKEAVIQPPREEYEEMKSSYCTVIENMNKEKAFLFEKYQEAQEEITKLKDTLKNQMTQEAGDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQVTNVSRAKAEEALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTTAKEMEGKISSLKEHLASKEGEVAKLEKQLLEEKAAMTDAMVPRSAYEKLQSSLESEVSVLASKLRDSVKEKEKAHSEVAQIRSEVSQMKREKENIQTLLKSKEQEVNELLQKCQHAQEELAEMKRHSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSASSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK", "length": 952, "header": "tr|A0A3Q1MIZ7-1|A0AAA9STV0_BOVIN Computationally mapped isoform of Retinoic acid induced 14 OS=Bos taurus OX=9913 GN=RAI14 PE=4 SV=2 CANONICAL=A0AAA9STV0-1" }, "locus": { "chromosome": "20", "start_pos": 39446652, "end_pos": 39314841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070752.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070752.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074309.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074309.2" } ] } }, { "isoform_ac": "A0A3Q1MVC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0/entry#A0A3Q1MVC6-1", "sequence": { "sequence": "MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAATKGHVECLRVMVTHGVDVTAQDTAGHSALHLAAKNSHHECVKKLLQSKCPAESIDSSGKTALHYAAAQGCLQAVQVLCEHRSPINLKDLDGNIPLLLAVQNGHSEVCRFLLDHGADVNSRDKNGRTALMLACEIGSSNIVEALIKKGADLNLVDSLGHNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENRDRLSDSTTGADSLLDVSSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKTPREGEADLSFDSYHSTQTDLAPSLGKPSENPPLDSKPSPSVITHSSSKSTLDSDVRIQQLQEVLHDLQKRLESSEAERKQLQAELQTRRTESVCLNNAEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESVDTYSHLHELRITEEEMDVLKRDLQGALEESERNKEKVRELEEKLAEREKEAVIQPPREEYEEMKSSYCTVIENMNKEKAFLFEKYQEAQEEITKLKDTLKNQMTQEAGDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQVTNVSRAKAEEALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTTAKEMEGKISSLKEHLASKEGEVAKLEKQLLEEKAAMTDAMVPRSAYEKLQSSLESEVSVLASKLRDSVKEKEKAHSEVAQIRSEVSQMKREKENIQTLLKSKEQEVNELLQKCQHAQEELAEMKRHSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSASSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKKDF", "length": 982, "header": "tr|A0A3Q1MVC6-1|A0AAA9STV0_BOVIN Computationally mapped isoform of Retinoic acid induced 14 OS=Bos taurus OX=9913 GN=RAI14 PE=4 SV=2 CANONICAL=A0AAA9STV0-1" }, "locus": { "chromosome": "20", "start_pos": 39446652, "end_pos": 39314696, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079614.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079614.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058947.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058947.2" } ] } }, { "isoform_ac": "A0AAA9RYD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0/entry#A0AAA9RYD3-1", "sequence": { "sequence": "MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAATKGHVECLRVMVTHGVDVTAQDTAGHSALHLAAKNSHHECVKKLLQSKCPAESIDSSGKTALHYAAAQGCLQAVQVLCEHRSPINLKDLDGNIPLLLAVQNGHSEVCRFLLDHGADVNSRDKNGRTALMLACEIGSSNIVEALIKKGADLNLVDSLGHNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQDMQMVESVGVELVDMEGQLYIFKKRNGSNEKHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKQAEISSIRENRDRLSDSTTGADSLLDVSSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKTPREGEADLSFDSYHSTQTDLAPSLGKPSENPPLDSKPSPSVITHSSSKSTLDSDVRIQQLQEVLHDLQKRLESSEAERKQLQAELQTRRTESVCLNNAEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESVDTYSHLHELRITEEEMDVLKRDLQGALEESERNKEKVRELEEKLAEREKEAVIQPPREEYEEMKSSYCTVIENMNKEKAFLFEKYQEAQEEITKLKDTLKNQMTQEAGDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQVTNVSRAKAEEALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTTAKEMEGKISSLKEHLASKEGEVAKLEKQLLEEKAAMTDAMVPRSAYEKLQSSLESEVSVLASKLRDSVKEKEKAHSEVAQIRSEVSQMKREKENIQTLLKSKEQEVNELLQKCQHAQEELAEMKRHSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSASSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK", "length": 1012, "header": "tr|A0AAA9RYD3-1|A0AAA9STV0_BOVIN Computationally mapped isoform of Retinoic acid induced 14 OS=Bos taurus OX=9913 GN=RAI14 PE=4 SV=1 CANONICAL=A0AAA9STV0-1" }, "locus": { "chromosome": "20", "start_pos": 39446652, "end_pos": 39314841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093020.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093020.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077620.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077620.1" } ] } }, { "isoform_ac": "A0AAA9STV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0/entry#A0AAA9STV0-1", "sequence": { "sequence": "MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAATKGHVECLRVMVTHGVDVTAQDTAGHSALHLAAKNSHHECVKKLLQSKCPAESIDSSGKTALHYAAAQGCLQAVQVLCEHRSPINLKDLDGNIPLLLAVQNGHSEVCRFLLDHGADVNSRDKNGRTALMLACEIGSSNIVEALIKKGADLNLVDSLGHNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKQAEISSIRENRDRLSDSTTGADSLLDVSSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKTPREGEADLSFDSYHSTQTDLAPSLGKPSENPPLDSKPSPSVITHSSSKSTLDSDVRIQQLQEVLHDLQKRLESSEAERKQLQAELQTRRTESVCLNNAEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESVDTYSHLHELRITEEEMDVLKRDLQGALEESERNKEKVRELEEKLAEREKEAVIQPPREEYEEMKSSYCTVIENMNKEKAFLFEKYQEAQEEITKLKDTLKNQMTQEAGDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQVTNVSRAKAEEALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTTAKEMEGKISSLKEHLASKEGEVAKLEKQLLEEKAAMTDAMVPRSAYEKLQSSLESEVSVLASKLRDSVKEKEKAHSEVAQIRSEVSQMKREKENIQTLLKSKEQEVNELLQKCQHAQEELAEMKRHSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSASSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK", "length": 981, "header": "tr|A0AAA9STV0-1|A0AAA9STV0_BOVIN Isoform 1 of Retinoic acid induced 14 OS=Bos taurus OX=9913 GN=RAI14 PE=4 SV=1 CANONICAL=A0AAA9STV0-1" }, "locus": { "chromosome": "20", "start_pos": 39446652, "end_pos": 39314841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089390.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089390.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086528.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086528.1" } ] } }, { "isoform_ac": "F1N0H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0/entry#F1N0H4-1", "sequence": { "sequence": "MCKLASWSLKVASPSPFQLKKVALFQSLVTGRYFIELWMFSFGKPAFLGVSMVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAATKGHVECLRVMVTHGVDVTAQDTAGHSALHLAAKNSHHECVKKLLQSKCPAESIDSSGKTALHYAAAQGCLQAVQVLCEHRSPINLKDLDGNIPLLLAVQNGHSEVCRFLLDHGADVNSRDKNGRTALMLACEIGSSNIVEALIKKGADLNLVDSLGHNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKQAEISSIRENRDRLSDSTTGADSLLDVSSEADQQDLLVLLQAKVASLTLHNKELQDKLQAKTPREGEADLSFDSYHSTQTDLAPSLGKPSENPPLDSKPSPSVITHSSSKSTLDSDVRIQQLQEVLHDLQKRLESSEAERKQLQAELQTRRTESVCLNNAEISENGSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESVDTYSHLHELRITEEEMDVLKRDLQGALEESERNKEKVRELEEKLAEREKEAVIQPPREEYEEMKSSYCTVIENMNKEKAFLFEKYQEAQEEITKLKDTLKNQMTQEAGDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQVTNVSRAKAEEALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTTAKEMEGKISSLKEHLASKEGEVAKLEKQLLEEKAAMTDAMVPRSAYEKLQSSLESEVSVLASKLRDSVKEKEKAHSEVAQIRSEVSQMKREKENIQTLLKSKEQEVNELLQKCQHAQEELAEMKRHSESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSASSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK", "length": 1025, "header": "tr|F1N0H4-1|F1N0H4_BOVIN Computationally mapped isoform of Retinoic acid induced 14 OS=Bos taurus OX=9913 GN=RAI14 PE=4 SV=3 CANONICAL=A0AAA9STV0-1" }, "locus": { "chromosome": "20", "start_pos": 39375725, "end_pos": 39314841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009296.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009296.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009296.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009296.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525869", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525869", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 478, "end_pos": 480, "annotation": "n_glycosylation_sequon" }, { "start_pos": 690, "end_pos": 692, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 478, "end_pos": 480 }, { "start_pos": 690, "end_pos": 692 }, { "start_pos": 976, "end_pos": 978 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STK5-1", "uniprot_ac": "A0AAA9STK5", "uniprot_id": "A0AAA9STK5_BOVIN", "mass": { "chemical_mass": 20811.0, "monoisotopic_mass": 20811.0 }, "refseq": { "ac": "XP_015329253", "name": "ADP-ribosylation factor-like protein 11 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329253" }, "gene_names": [ { "name": "ARL11", "type": "recommended", "evidence": [ { "id": "A0AAA9STK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ] }, { "name": "ARL11", "type": "synonym", "evidence": [ { "id": "XP_015329253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329253" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-like protein 11", "type": "recommended", "evidence": [ { "id": "A0AAA9STK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-like protein 11 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015329253", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329253" } ] } ], "function": [ { "annotation": "May play a role in apoptosis. May act as a tumor suppressor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S028", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028#function" }, { "database": "UniProtKB", "id": "ARBA00054648", "url": "https://www.uniprot.org/uniprotkb/ARBA00054648#function" }, { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5#function" }, { "database": "UniProtKB", "id": "F1N3N7", "url": "https://www.uniprot.org/uniprotkb/F1N3N7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5", "locus": { "chromosome": "12", "start_pos": 19197289, "end_pos": 19179769, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016998", "url": "https://www.ensembl.org/id/ENSBTAG00000016998" } ] } } ], "crossref": [ { "id": "A0AAA9STK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016998", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016998", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513113", "url": "https://www.ncbi.nlm.nih.gov/gene/513113", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513113", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513113", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQAVETC", "url": "https://omabrowser.org/oma/group/GQAVETC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N3N7", "url": "https://www.orthodb.org/?gene=F1N3N7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015329253", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329253", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S028", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S028-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3N7", "url": "https://www.uniprot.org/uniprotkb/F1N3N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3N7-1", "url": "https://www.uniprot.org/uniprotkb/F1N3N7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSVSSRSHRVEAQVVMMGLDSAGKTTLLYKLKGHQLVDTLPTVGFNVEPLEAPGQACLTLWDVGGQSPLRASWKDYLEGTAVLVFVLDSTDEARLPEAVAELTEVLEDPHLDGVPLLVLANKHEAPHALPLPEIRNRLGLQRFPGLCWQLRACSALTGEGLPEALGSLRRLLSYRSPRSLQEAHGILAPGPG", "length": 193, "header": "tr|A0AAA9STK5-1|A0AAA9STK5_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 11 OS=Bos taurus OX=9913 GN=ARL11 PE=3 SV=1 CANONICAL=A0AAA9STK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S028-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5/entry#A0AAA9S028-1", "sequence": { "sequence": "MGSVSSRSHRVEAQVVMMGLDSAGKTTLLYKLKGHQLVDTLPTVGFNVEPLEAPGQACLTLWDVGGQSPLRASWKDYLEGTAVLVFVLDSTDEARLPEAVAELTEVLEDPHLDGVPLLVLANKHEAPHALPLPEIRNRLGLQRFPGLCWQLRACSALTGEGLPEALGSLRRLLSYRSPRSLQVSAGGGRRET", "length": 192, "header": "tr|A0AAA9S028-1|A0AAA9STK5_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 11 OS=Bos taurus OX=9913 GN=ARL11 PE=3 SV=1 CANONICAL=A0AAA9STK5-1" }, "locus": { "chromosome": "12", "start_pos": 19181263, "end_pos": 19180688, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075416.1" } ] } }, { "isoform_ac": "A0AAA9STK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5/entry#A0AAA9STK5-1", "sequence": { "sequence": "MGSVSSRSHRVEAQVVMMGLDSAGKTTLLYKLKGHQLVDTLPTVGFNVEPLEAPGQACLTLWDVGGQSPLRASWKDYLEGTAVLVFVLDSTDEARLPEAVAELTEVLEDPHLDGVPLLVLANKHEAPHALPLPEIRNRLGLQRFPGLCWQLRACSALTGEGLPEALGSLRRLLSYRSPRSLQEAHGILAPGPG", "length": 193, "header": "tr|A0AAA9STK5-1|A0AAA9STK5_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 11 OS=Bos taurus OX=9913 GN=ARL11 PE=3 SV=1 CANONICAL=A0AAA9STK5-1" }, "locus": { "chromosome": "12", "start_pos": 19197103, "end_pos": 19180688, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117784.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117784.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087305.1" } ] } }, { "isoform_ac": "F1N3N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5/entry#F1N3N7-1", "sequence": { "sequence": "MGSVSSRSHRVEAQVVMMGLDSAGKTTLLYKLKGHQLVDTLPTVGFNVEPLEAPGQACLTLWDVGGQSPLRASWKDYLEGTAVLVFVLDSTDEARLPEAVAELTEVLEDPHLDGVPLLVLANKHEAPHALPLPEIRNRLGLQRFPGLCWQLRACSALTGEGLPEALGSLRRLLSYRSPRSLQAQGVPSRCWGTQDEDSEGRKQEKARLLSK", "length": 211, "header": "tr|F1N3N7-1|F1N3N7_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 11 OS=Bos taurus OX=9913 GN=ARL11 PE=3 SV=3 CANONICAL=A0AAA9STK5-1" }, "locus": { "chromosome": "12", "start_pos": 19194836, "end_pos": 19180688, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055638.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055638.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052723.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052723.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513113", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513113", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XIK4-1", "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "ARL11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEQILSGVSMGKLFSKGWRKRDARVVMLGLDLAGKSTILYQLKGSQAMETCPTVGFNVEAMRTPCGMSFNLWDVGGQPSLRASWHHYLEDTNILVFVLDSADTARLPEALAVLEETLGHPGLAEVPVLLLANKQELPGAMAPAELGQQLCRGRLAGHPWVLRGCSAHTGQGLQDILRVLGELLRGLRQGSLIPEQPLS", "length": 199 }, "evidence": [ { "id": "A0AAA9STK5", "url": "https://omabrowser.org/oma/group/A0AAA9STK5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H8Q8-1", "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "Arl11", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGPVNSRGHKAEAQVVMMGLDSAGKTTILYKLKGNPLVETLPTVGFNVEPLEAPGHVSLILWDIGGQTQLRATWKDYLEGTNILVYVLDSTDEARLPEAVAELNEVLEDPNMAGVPFLVLANKQEAPDALPLLEIRDRLGLERFQDNCWELRACSALTGQGLQEALQSLLHLLRSC", "length": 176 }, "evidence": [ { "id": "A0AAA9STK5", "url": "https://omabrowser.org/oma/group/A0AAA9STK5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5BK71-1", "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "Arl11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSVNSRGHKAQVVMLGLDCAGKTTILYKLKGNRLVDTLPTVGFNVEPLEAPGHVSLTLWDIGGQTQLRATWKDYLEGIDLLVYVLDSTDEARLPEAVAELEEVLEDPNMAGVPFLVLANKQEAPDALPLLEIRNRLDLERFQDHCWELRACSALTGQGLQEARQSLLHLLRS", "length": 173 }, "evidence": [ { "id": "A0AAA9STK5", "url": "https://omabrowser.org/oma/group/A0AAA9STK5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P3A9-1", "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "Arl11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSVNSRGHKAEAQVVMMGLDSAGKTTILYKLKGNQLVDTLPTVGFNVEPLEAPGHVSLTLWDIGGQTQLRATWKDYLEGIDLLVYVLDSTDEARLPEAVAELKEVLEDPNMAGVPFLVLANKQEAPGALPLLEIRNRLGLEGFQKHCWELRACSALTGQGLQEALQSLLHLLKSR", "length": 176 }, "evidence": [ { "id": "A0AAA9STK5", "url": "https://omabrowser.org/oma/group/A0AAA9STK5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969Q4-1", "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "ARL11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS", "length": 196 }, "evidence": [ { "id": "A0AAA9STK5", "url": "https://omabrowser.org/oma/group/A0AAA9STK5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9S028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028#function" }, { "id": "A0AAA9S028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" }, { "id": "A0AAA9STK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5#function" }, { "id": "A0AAA9STK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" }, { "id": "F1N3N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3N7#function" }, { "id": "F1N3N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3N7" } ], "binding_site_uniprot": 26, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 26, "end_pos": 26, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9S028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028#function" }, { "id": "A0AAA9S028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S028" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" }, { "id": "A0AAA9STK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5#function" }, { "id": "A0AAA9STK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK5" }, { "id": "F1N3N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3N7#function" }, { "id": "F1N3N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3N7" } ], "binding_site_uniprot": 43, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 43, "end_pos": 43, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVT5-1", "uniprot_ac": "A0AAA9SVT5", "uniprot_id": "A0AAA9SVT5_BOVIN", "mass": { "chemical_mass": 66107.0, "monoisotopic_mass": 66107.0 }, "refseq": {}, "gene_names": [ { "name": "PCSK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ] } ], "protein_names": [ { "name": "Neuroendocrine convertase 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.94", "type": "synonym", "evidence": [ { "id": "A0AAA9SVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5/entry#names_and_taxonomy" } ] }, { "name": "Prohormone convertase 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5/entry#names_and_taxonomy" } ] }, { "name": "Proprotein convertase 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5#function" }, { "database": "UniProtKB", "id": "ARBA00037494", "url": "https://www.uniprot.org/uniprotkb/ARBA00037494#function" }, { "database": "UniProtKB", "id": "F6Q5F4", "url": "https://www.uniprot.org/uniprotkb/F6Q5F4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCSK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5", "locus": { "chromosome": "13", "start_pos": 37744161, "end_pos": 37506073, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008687", "url": "https://www.ensembl.org/id/ENSBTAG00000008687" } ] } } ], "crossref": [ { "id": "A0AAA9SVT5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008687", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008687", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281968", "url": "https://www.ncbi.nlm.nih.gov/gene/281968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LAKQWHS", "url": "https://omabrowser.org/oma/group/LAKQWHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6Q5F4", "url": "https://www.orthodb.org/?gene=F6Q5F4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00082", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00082", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16470", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16470", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q5F4", "url": "https://www.uniprot.org/uniprotkb/F6Q5F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q5F4-1", "url": "https://www.uniprot.org/uniprotkb/F6Q5F4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGGCISQGKAAAGLLFCVMVFASAERPVFTNHFLVELHRGGEEEARQVAAEHGFGVRKVKRALQQEGFNRKKRGYRDINEIDINVNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYGSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPTTGKLVLTLTTDACEGKENFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSILLSRRPRDDDAKVGFDKWPFMTTHTWGEDARGTWILELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVQRSLKSILGKD", "length": 603, "header": "tr|A0AAA9SVT5-1|A0AAA9SVT5_BOVIN Isoform 1 of Neuroendocrine convertase 2 OS=Bos taurus OX=9913 GN=PCSK2 PE=3 SV=1 CANONICAL=A0AAA9SVT5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5/entry#A0AAA9SVT5-1", "sequence": { "sequence": "MRGGCISQGKAAAGLLFCVMVFASAERPVFTNHFLVELHRGGEEEARQVAAEHGFGVRKVKRALQQEGFNRKKRGYRDINEIDINVNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYGSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPTTGKLVLTLTTDACEGKENFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSILLSRRPRDDDAKVGFDKWPFMTTHTWGEDARGTWILELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVQRSLKSILGKD", "length": 603, "header": "tr|A0AAA9SVT5-1|A0AAA9SVT5_BOVIN Isoform 1 of Neuroendocrine convertase 2 OS=Bos taurus OX=9913 GN=PCSK2 PE=3 SV=1 CANONICAL=A0AAA9SVT5-1" }, "locus": { "chromosome": "13", "start_pos": 37744021, "end_pos": 37506150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106288.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106288.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088126.1" } ] } }, { "isoform_ac": "F6Q5F4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5/entry#F6Q5F4-1", "sequence": { "sequence": "MRGGCISQGKAAAGLLFCVMVFASAERPVFTNHFLVELHRGGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLQHQQQLERDPRVKRALQQEGFNRKKRGYRDINEIDINVNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYGSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPTTGKLVLTLTTDACEGKENFVRYLEHVQAVVTVNATRRGDLNINMTSPMGTKSILLSRRPRDDDAKVGFDKWPFMTTHTWGEDARGTWILELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVQRSLKSILGKD", "length": 638, "header": "tr|F6Q5F4-1|F6Q5F4_BOVIN Computationally mapped isoform of Neuroendocrine convertase 2 OS=Bos taurus OX=9913 GN=PCSK2 PE=3 SV=1 CANONICAL=A0AAA9SVT5-1" }, "locus": { "chromosome": "13", "start_pos": 37744021, "end_pos": 37506150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011451.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011451.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011451.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011451.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MRM8-1", "protein_name": "Neuroendocrine convertase 2", "gene_name": "Pcsk2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEGGCGSQWKAAGLLFCVMVFASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLSKAKRRRSLHHKRQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLANNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQMIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLETNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSILRKN", "length": 637 }, "evidence": [ { "id": "A0AAA9SVT5", "url": "https://omabrowser.org/oma/group/A0AAA9SVT5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P16519-1", "protein_name": "Neuroendocrine convertase 2", "gene_name": "PCSK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN", "length": 638 }, "evidence": [ { "id": "A0AAA9SVT5", "url": "https://omabrowser.org/oma/group/A0AAA9SVT5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P21661-1", "protein_name": "Neuroendocrine convertase 2", "gene_name": "Pcsk2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGGCGSQWKAAGFLFCVMVFASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLKTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSILRKN", "length": 637 }, "evidence": [ { "id": "A0AAA9SVT5", "url": "https://omabrowser.org/oma/group/A0AAA9SVT5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P28841-1", "protein_name": "Neuroendocrine convertase 2", "gene_name": "Pcsk2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGGCGSQWKAAGLLFCVMVFASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLQTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSILRKN", "length": 637 }, "evidence": [ { "id": "A0AAA9SVT5", "url": "https://omabrowser.org/oma/group/A0AAA9SVT5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VBC7-1", "protein_name": "Neuroendocrine convertase 2", "gene_name": "amon", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAATWSWLLAPFLLLHWASAGAGGGAGGSGAGLSGPAVFTSSFLVRFRRGVDNSFAHDVADKYGFDNLGPLVGADGHEYHFKHRTLPHARSRRSLTHTRALKSHPAVHTAVQQPGFKRVKRGLRPAVPAIHGMKFDLKVGEGNRIDEEPTDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLGNIYVWASGDGGEEDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNSLFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSRRANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLHGTKEAPYRTLHPSSPHSKLAIVKKAHEDKKMK", "length": 654 }, "evidence": [ { "id": "A0AAA9SVT5", "url": "https://omabrowser.org/oma/group/A0AAA9SVT5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" }, { "name": "intracellular organelle lumen", "id": "GO:0070013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "peptide hormone processing", "id": "GO:0016486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016486", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVT5" }, { "id": "PS51829", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51829" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "P/Homo B", "eco_id": "ECO_0000259", "start_pos": 426, "end_pos": 562, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.94", "ec_name": "Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.", "evidence": [ { "id": "3.4.21.94", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.94" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 340, "end_pos": 342 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 489, "end_pos": 491 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU47-1", "uniprot_ac": "A0AAA9SU47", "uniprot_id": "A0AAA9SU47_BOVIN", "mass": { "chemical_mass": 62753.0, "monoisotopic_mass": 62753.0 }, "refseq": { "ac": "XP_024848701", "name": "pre-mRNA 3'-end-processing factor FIP1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848701" }, "gene_names": [ { "name": "FIP1L1", "type": "recommended", "evidence": [ { "id": "A0AAA9SU47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47" } ] }, { "name": "FIP1L1", "type": "synonym", "evidence": [ { "id": "XP_024848701", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848701" } ] } ], "protein_names": [ { "name": "Pre-mRNA 3'-end-processing factor FIP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SU47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#names_and_taxonomy" } ] }, { "name": "FIP1-like 1 protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SU47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#names_and_taxonomy" } ] }, { "name": "pre-mRNA 3'-end-processing factor FIP1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024848701", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848701" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FIP1L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47", "locus": { "chromosome": "6", "start_pos": 69005828, "end_pos": 68940826, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020653", "url": "https://www.ensembl.org/id/ENSBTAG00000020653" } ] } } ], "crossref": [ { "id": "A0AAA9SU47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020653", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020653", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138550", "url": "https://www.ncbi.nlm.nih.gov/gene/100138550", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007854", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007854", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXT4", "url": "https://www.orthodb.org/?gene=A0A3Q1LXT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13484", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13484", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13484:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13484:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05182", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05182", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848701", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848701", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7R4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHTDLAKDLDENEVERPEEENASANPPSGIEDETPENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTAVGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNAEKETVLPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSTPSWPSLVDTSKQWDYYSRREKDRDRDRDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE", "length": 559, "header": "tr|A0AAA9SU47-1|A0AAA9SU47_BOVIN Isoform 1 of Pre-mRNA 3'-end-processing factor FIP1 OS=Bos taurus OX=9913 GN=FIP1L1 PE=3 SV=2 CANONICAL=A0AAA9SU47-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#A0A3Q1LXT4-1", "sequence": { "sequence": "MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETPENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTAGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNAEKETVLPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSTPSWPSLVDTSKQWDYYSRREKDRDRDRDRDRERDRDRDRERERTRERERERDHSPTPSVFNRYVHDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE", "length": 555, "header": "tr|A0A3Q1LXT4-1|A0A3Q1LXT4_BOVIN Computationally mapped isoform of Pre-mRNA 3'-end-processing factor FIP1 OS=Bos taurus OX=9913 GN=FIP1L1 PE=3 SV=2 CANONICAL=A0AAA9SU47-1" }, "locus": { "chromosome": "6", "start_pos": 69005669, "end_pos": 68941106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084423.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084423.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060349.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060349.2" } ] } }, { "isoform_ac": "A0AAA9RXT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#A0AAA9RXT5-1", "sequence": { "sequence": "MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHTDLAKDLDENEVERPEEENASANPPSGIEDETPENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTAVGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTGNAEKETVLPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSTPSWPSLVDTSKQWDYYSRREKDRDRDRDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE", "length": 536, "header": "tr|A0AAA9RXT5-1|A0AAA9SU47_BOVIN Computationally mapped isoform of Pre-mRNA 3'-end-processing factor FIP1 OS=Bos taurus OX=9913 GN=FIP1L1 PE=3 SV=2 CANONICAL=A0AAA9SU47-1" }, "locus": { "chromosome": "6", "start_pos": 69005669, "end_pos": 68941106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107255.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107255.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078340.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078340.2" } ] } }, { "isoform_ac": "A0AAA9SU47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#A0AAA9SU47-1", "sequence": { "sequence": "MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHTDLAKDLDENEVERPEEENASANPPSGIEDETPENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTAVGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNAEKETVLPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSTPSWPSLVDTSKQWDYYSRREKDRDRDRDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE", "length": 559, "header": "tr|A0AAA9SU47-1|A0AAA9SU47_BOVIN Isoform 1 of Pre-mRNA 3'-end-processing factor FIP1 OS=Bos taurus OX=9913 GN=FIP1L1 PE=3 SV=2 CANONICAL=A0AAA9SU47-1" }, "locus": { "chromosome": "6", "start_pos": 69005669, "end_pos": 68941106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094983.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094983.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087673.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087673.2" } ] } }, { "isoform_ac": "A0AAA9T2X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#A0AAA9T2X5-1", "sequence": { "sequence": "MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHTDLAKDLDENEVERPEEENASANPPSGIEDETPENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTAGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITVQQGRTGNAEKETVLPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSTPSWPSLVDTSKQWDYYSRREKDRDRDRDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE", "length": 508, "header": "tr|A0AAA9T2X5-1|A0AAA9T2X5_BOVIN Computationally mapped isoform of Pre-mRNA 3'-end-processing factor FIP1 OS=Bos taurus OX=9913 GN=FIP1L1 PE=3 SV=1 CANONICAL=A0AAA9SU47-1" }, "locus": { "chromosome": "6", "start_pos": 69005669, "end_pos": 68941106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117321.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117321.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093143.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093143.1" } ] } }, { "isoform_ac": "A0AAA9T7R4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47/entry#A0AAA9T7R4-1", "sequence": { "sequence": "MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETPENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTAGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNAEKETVLPSTKAEFTSPPSLFKTGLPPSRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVMKNDTDTGSMQKEAMSATEQVGRKKNDTEKDDTERKRKPDTSPLEAIVDVAMKVKKETVIGDTSTKNLKEAKKEKKLAVSLPLNRRAPKLHLQNRRGHGLLCIVMPEVDTVNLVIFLDNV", "length": 507, "header": "tr|A0AAA9T7R4-1|A0AAA9T7R4_BOVIN Computationally mapped isoform of Pre-mRNA 3'-end-processing factor FIP1 OS=Bos taurus OX=9913 GN=FIP1L1 PE=3 SV=2 CANONICAL=A0AAA9SU47-1" }, "locus": { "chromosome": "6", "start_pos": 69005748, "end_pos": 68941106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125533.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125533.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092819.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092819.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 345, "start_aa": "Thr", "end_pos": 345, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr345", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 403, "start_aa": "Thr", "end_pos": 403, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr403", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 556, "start_aa": "Thr", "end_pos": 556, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr556", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47" } ], "pmid": "" }, { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SU47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU47" }, { "id": "PF05182", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05182" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pre-mRNA polyadenylation factor Fip1", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 197, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 345, 403, 556 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STJ2-1", "uniprot_ac": "A0AAA9STJ2", "uniprot_id": "A0AAA9STJ2_BOVIN", "mass": { "chemical_mass": 140857.0, "monoisotopic_mass": 140857.0 }, "refseq": { "ac": "XP_015331330", "name": "zinc finger protein 536 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331330" }, "gene_names": [ { "name": "ZNF536", "type": "recommended", "evidence": [ { "id": "A0AAA9STJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ] }, { "name": "ZNF536", "type": "synonym", "evidence": [ { "id": "XP_015331330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331330" } ] } ], "protein_names": [ { "name": "Zinc finger protein 536", "type": "recommended", "evidence": [ { "id": "A0AAA9STJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 536 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_015331330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331330" } ] } ], "function": [ { "annotation": "Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXW6#function" }, { "database": "UniProtKB", "id": "ARBA00057406", "url": "https://www.uniprot.org/uniprotkb/ARBA00057406#function" }, { "database": "UniProtKB", "id": "A0AAA9S883", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S883#function" }, { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2#function" }, { "database": "UniProtKB", "id": "F1MW46", "url": "https://www.uniprot.org/uniprotkb/F1MW46#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF536", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2", "locus": { "chromosome": "18", "start_pos": 41220200, "end_pos": 40841227, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007262", "url": "https://www.ensembl.org/id/ENSBTAG00000007262" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007262", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007262", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520269", "url": "https://www.ncbi.nlm.nih.gov/gene/520269", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520269", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520269", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKMTQGH", "url": "https://omabrowser.org/oma/group/EKMTQGH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXW6", "url": "https://www.orthodb.org/?gene=A0A3Q1LXW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MW46", "url": "https://www.orthodb.org/?gene=F1MW46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45925", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45925", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45925:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45925:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16606", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16606", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015331330", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331330", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S883", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S883", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S883-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S883-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW46", "url": "https://www.uniprot.org/uniprotkb/F1MW46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW46-1", "url": "https://www.uniprot.org/uniprotkb/F1MW46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEASLCLGVSSAAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAPLDEKAHVPMSGQPMGSQMALLANQLGRDVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKSSLLQPRPDLKPLAHAQQAPLAACNLALPTNHSLPDVANPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMAADKASLSEPSQLYGKGELPLKEKEVVGKLLTPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSRDFLSHGLNQALEYNLQGPGSLKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGDEDGLHGGPDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPSQDHRDELSNKAALFIRPDILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHTGQASGMSSEAPSDTLKGTDLPSKSTHFSEIGRAYQSIVNNGVNFQGSLQAFMDSFVLSSLKKEKDLKDKALSDPPSMKVHGVDGGEEKVGGKVAPRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKAALLPSVQSNKEMALSTMMGPLDSASEKMAQGQVKETLGEQKGGPWPSHVDPSFCSFPSDFYKQFSVYPGLLGSGAASSCPNREPDGKAHSEDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEEEDIDTEPEVMSKPPALSKDGGGDSGDGLLPTGAPQPVQGLVSPLPQASEKQWHSPGLLPAQDPTAGLPKPERGPQGLEKPMNVLSVLRAYSSDGLAAFNGLANSTANSGCIKRPDLCGK", "length": 1299, "header": "tr|A0AAA9STJ2-1|A0AAA9STJ2_BOVIN Isoform 1 of Zinc finger protein 536 OS=Bos taurus OX=9913 GN=ZNF536 PE=3 SV=1 CANONICAL=A0AAA9STJ2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2/entry#A0A3Q1LXW6-1", "sequence": { "sequence": "MEEASLCLGVSSAAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAPLDEKAHVPMSGQPMGSQMALLANQLGRDVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKSSLLQPRPDLKPLAHAQQAPLAACNLALPTNHSLPDVANPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMAADKASLSEPSQLYGKGELPLKEKEVVGKLLTPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSRDFLSHGLNQALEYNLQGPGSLKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGDEDGLHGGPDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPSQDHRDELSNKAALFIRPDILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHTGQASGMSSEAPSDTLKGTDLPSKSTHFSEIGRAYQSIVNNGVNFQGSLQAFMDSFVLSSLKKEKDLKDKALSDPPSMKVHGVDGGEEKVGGKVAPRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKAALLPSVQSNKEMALSTMMGPLDSASEKMAQGQVKETLGEQKGGPWPSHVDPSFCSFPSDFYKQFSVYPGLLGSGAASSCPNREPDGKAHSEDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEEEDIDTEPEVMSKPPALSKDGGGDSGDGLLPTGAPQPVQGLVSPLPQASEKQWHSPGLLPAQDPTAGLPKPERGPQGLEKPMNVLSVLRAYSSDGLAAFNGLANSTANSGCIKRPDLCGHRPFQCRYCPYSASQKGNLKTHVLCVHRMPFDNSQYPDRRFKRSRVDSEASGNFEDPAAVKAGSSAELTEEGSKAQEERN", "length": 1378, "header": "tr|A0A3Q1LXW6-1|A0A3Q1LXW6_BOVIN Computationally mapped isoform of Zinc finger protein 536 OS=Bos taurus OX=9913 GN=ZNF536 PE=3 SV=1 CANONICAL=A0AAA9STJ2-1" }, "locus": { "chromosome": "18", "start_pos": 41220197, "end_pos": 40972967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084215.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084215.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062084.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062084.1" } ] } }, { "isoform_ac": "A0AAA9S883-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2/entry#A0AAA9S883-1", "sequence": { "sequence": "MEEASLCLGVSSAAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAPLDEKAHVPMSGQPMGSQMALLANQLGRDVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKSSLLQPRPDLKPLAHAQQAPLAACNLALPTNHSLPDVANPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMAADKASLSEPSQLYGKGELPLKEKEVVGKLLTPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSRDFLSHGLNQALEYNLQGPGSLKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGDEDGLHGGPDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGHRPFQCRYCPYSASQKGNLKTHVLCVHRMPFDNSQYPDRRFKRSRVDSEASGNFEDPAAVKAGSSAELTEEGSKAQEERN", "length": 855, "header": "tr|A0AAA9S883-1|A0AAA9STJ2_BOVIN Computationally mapped isoform of Zinc finger protein 536 OS=Bos taurus OX=9913 GN=ZNF536 PE=3 SV=1 CANONICAL=A0AAA9STJ2-1" }, "locus": { "chromosome": "18", "start_pos": 41220197, "end_pos": 40972967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121834.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121834.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081452.1" } ] } }, { "isoform_ac": "A0AAA9STJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2/entry#A0AAA9STJ2-1", "sequence": { "sequence": "MEEASLCLGVSSAAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAPLDEKAHVPMSGQPMGSQMALLANQLGRDVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKSSLLQPRPDLKPLAHAQQAPLAACNLALPTNHSLPDVANPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMAADKASLSEPSQLYGKGELPLKEKEVVGKLLTPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSRDFLSHGLNQALEYNLQGPGSLKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGDEDGLHGGPDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPSQDHRDELSNKAALFIRPDILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHTGQASGMSSEAPSDTLKGTDLPSKSTHFSEIGRAYQSIVNNGVNFQGSLQAFMDSFVLSSLKKEKDLKDKALSDPPSMKVHGVDGGEEKVGGKVAPRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKAALLPSVQSNKEMALSTMMGPLDSASEKMAQGQVKETLGEQKGGPWPSHVDPSFCSFPSDFYKQFSVYPGLLGSGAASSCPNREPDGKAHSEDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEEEDIDTEPEVMSKPPALSKDGGGDSGDGLLPTGAPQPVQGLVSPLPQASEKQWHSPGLLPAQDPTAGLPKPERGPQGLEKPMNVLSVLRAYSSDGLAAFNGLANSTANSGCIKRPDLCGK", "length": 1299, "header": "tr|A0AAA9STJ2-1|A0AAA9STJ2_BOVIN Isoform 1 of Zinc finger protein 536 OS=Bos taurus OX=9913 GN=ZNF536 PE=3 SV=1 CANONICAL=A0AAA9STJ2-1" }, "locus": { "chromosome": "18", "start_pos": 41079331, "end_pos": 40972967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109157.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109157.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088670.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088670.1" } ] } }, { "isoform_ac": "F1MW46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2/entry#F1MW46-1", "sequence": { "sequence": "MEEASLCLGVSSAAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAPLDEKAHVPMSGQPMGSQMALLANQLGRDVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKSSLLQPRPDLKPLAHAQQAPLAACNLALPTNHSLPDVANPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMAADKASLSEPSQLYGKGELPLKEKEVVGKLLTPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSRDFLSHGLNQALEYNLQGPGSLKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGDEDGLHGGPDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPSQDHRDELSNKAALFIRPDILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHTGQASGMSSEAPSDTLKGTDLPSKSTHFSEIGRAYQSIVNNGVNFQGSLQAFMDSFVLSSLKKEKDLKDKALSDPPSMKVHGVDGGEEKVGGKVAPRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKAALLPSVQSNKEMALSTMMGPLDSASEKMAQGQVKETLGEQKGGPWPSHVDPSFCSFPSDFYKQFSVYPGLLGSGAASSCPNREPDGKAHSEDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEEEDIDTEPEVMSKPPALSKDGGGDSGDGLLPTGAPQPVQGLVSPLPQASEKQWHSPGLLPAQDPTAGLPKPERGPQGLEKPMNVLSVLRAYSSDGLAAFNGLANSTANSGCIKRPDLCDDSQ", "length": 1301, "header": "tr|F1MW46-1|A0AAA9STJ2_BOVIN Computationally mapped isoform of Zinc finger protein 536 OS=Bos taurus OX=9913 GN=ZNF536 PE=3 SV=4 CANONICAL=A0AAA9STJ2-1" }, "locus": { "chromosome": "18", "start_pos": 41158329, "end_pos": 40972967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009552.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009552.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009552.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009552.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520269", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520269", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M1V5-1", "protein_name": "Zinc finger protein 536", "gene_name": "Zfp536", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEASLCLGVSSTAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKPPAALEEKAHVPMSGQSMGSQMALLANQLGRDVDNSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKGSLLQPRSDLKPLAHAQQAPLATCNLTLPPNHSVPDVAHPAPSPKPANLQEDSVTPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPTEPEVSVPMGGLSQEAHANLYSRYLSCLQSGFMAPDKASLNEPSQLYGKGELPAKEKEVLGKLLSPISSMAHSVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLTRNHEDPLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSREFLSHGLNQTLEYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKSDEDALHVGVGLEERRGSGSDQESQSVSRSTTPGSSNVTEESGAGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRAGGVQQQALLRDRNLGSAMKDCPYCAKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQEHKDETSSKAPMFIRPDILRGAFKGLPGIDFRSGPASQQWTSSSMLSSGDHSGQATGMSSELSSDALKASDLPSKSSHFSEIGRAYQNVVSNGVNFQGSLQAFMDSFVLSSLKKKDMKDKVPSEAHSMKAHTAEGGEEKASVKPSQRKTEKSQYEPLDLSVRPDATTLPGSSVTMQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDHPTGVTANCKEQVREAGKVSVLPPIQSNKEMALSSTVGSVLDSAPEKMAQGPAKETLGDQKSGQWPSHMDPAFCTFPSDFYKQFGVYPTMVGSGGPGSCLNKNPEGKAHPEDDAPILIPETANKNTTDDLSDIASSEDMDSSSKGENNEEEEIDTEPEMMSKPLSALSKDGSHEGGESLLPPGAPQPIQGLVSPLAQAAEEQWHGPGILPAQDPSAGLPKPERGPPGLEKPMSMLSVLRAYSADGLAAFNGLASSTANSGCIKRPDLCGHRPFQCHYCPYSASQKGNLKTHVLCVHRMPFDNSQYPDRRFKRSRVDSEASGNFEEAAAVKAGSFAELTDERGKGQEEGN", "length": 1383 }, "evidence": [ { "id": "A0AAA9STJ2", "url": "https://omabrowser.org/oma/group/A0AAA9STJ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15090-1", "protein_name": "Zinc finger protein 536", "gene_name": "ZNF536", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEASLCLGVSSAEPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKPPASLEEKAHVPMSGQPMGSQMALLANQLGREVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQLKGSLLQPRPDLKPPPHAQQAPLAACTLALQANHSVPDVAHPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMTPDKAGLSEPSQLYGKGELPMKEKEALGKLLSPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHPLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGSQRDLPSKLDPLESSRDFLSHGLNQTLEYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGEEDGLHVGLDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRGAFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWTGHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCGK", "length": 1300 }, "evidence": [ { "id": "A0AAA9STJ2", "url": "https://omabrowser.org/oma/group/A0AAA9STJ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K083-1", "protein_name": "Zinc finger protein 536", "gene_name": "Znf536", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEASLCLGVSSTAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAALEEKAHVPMSGQSMGSQMALLANQLGRDVDNSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKGSLLQPRSDLKPLAHAQQAPLATCNLALPPNHSVPDVAHPAPSPKPANLQEDSVTPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPTEPEVAVPMGGLSQEAHANLYSRYLSCLQSGFMAPDKASLNEPSQLYGKGELPAKEKEVLGKLLSPISSMAHSVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLSRNHEDPLANTGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSREFLSHGLNQTLDYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKSDEDALHVGVGLEERRGSGSDQESQSVSRSTTPGSSNVTEESGAGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRAGGVQQQALLRDRNLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQEHKDETSSKAPMFIRPDILRGAFKGLPGIDFRGGPASQQWTAGMLSSGDHSGQATGMPSELSSDALKGSDLPSKSSHYSEIGRAYQNIVSNGVNFQGSLQAFMDSFVLSSLKKKDTKDKVPSDAHPMKAHTAEGGEEKASMKPSQRKSEKSQYEPLDLSVRPDAPTLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGRAKRKDHPTGVTVNCKEQGREASKVSVLPSLQSNKEMALPSAVGVLDSAPEKLAQGPAKETLGDPKSGQWPNHMDPAFCTFPSDFYKQFGVYPAMVGSGAPGSCLNKNTEGKTHPDDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEDEELDTEPEMTSKPLSALSKDGSSEGGDSLLSPGAPQPIQGLVSPLAQAAEEQWHSPGLLPAQDPSAGLPKPERGPPGLEKPMSMLSVLRAYSADGLAAFNGLASSTANSGCIKRPDLCGKF", "length": 1302 }, "evidence": [ { "id": "A0AAA9STJ2", "url": "https://omabrowser.org/oma/group/A0AAA9STJ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1156, "end_pos": 1158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1283, "end_pos": 1285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 693, "end_pos": 695, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STJ2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 157, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1156, "end_pos": 1158 }, { "start_pos": 1283, "end_pos": 1285 }, { "start_pos": 245, "end_pos": 247 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 693, "end_pos": 695 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "exact_o_linked_glycan_sites", "count": 1 }, { "field": "exact_o_linked_glycans", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "exact_o_linked_glycan_sites", "count": 1 }, { "field": "exact_o_linked_glycans", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1285 }, { "field": "total_sites", "count": 836 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1232 }, { "field": "total_sites", "count": 807 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 53 }, { "field": "total_sites", "count": 47 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SVU7-1", "uniprot_ac": "A0AAA9SVU7", "uniprot_id": "A0AAA9SVU7_BOVIN", "mass": { "chemical_mass": 52371.0, "monoisotopic_mass": 52371.0 }, "refseq": {}, "gene_names": [ { "name": "SMAP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ] } ], "protein_names": [ { "name": "Small ArfGAP 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SVU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMAP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7", "locus": { "chromosome": "9", "start_pos": 9975225, "end_pos": 9785178, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038190", "url": "https://www.ensembl.org/id/ENSBTAG00000038190" } ] } } ], "crossref": [ { "id": "A0AAA9SVU7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038190", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038190", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08839", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08839", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516032", "url": "https://www.ncbi.nlm.nih.gov/gene/516032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516032", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516032", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LMH0", "url": "https://www.orthodb.org/?gene=A0A3Q1LMH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPR9", "url": "https://www.orthodb.org/?gene=A0A3Q1MPR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MU99", "url": "https://www.orthodb.org/?gene=F1MU99", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45705", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45705", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45705:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45705:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LMH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPR9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPR9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU99", "url": "https://www.uniprot.org/uniprotkb/F1MU99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU99-1", "url": "https://www.uniprot.org/uniprotkb/F1MU99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQEILVAFERKIENYSGKLQVVVECMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNIASSDAPLQPLVSSPSLQAAVEKNKLEKEKEKKKEEKKKEKEPEKPTKPLTTEKLQKKEDQQLEPKKSTSPKKAAEPTVDLLGLDGPAEAPVTNGSAVVGPALNDDLDIFGPMISNPLPATVMPPAQGTSSAPAAATLSAVTSGDLDLFTEQAAKSEEVAKKQLSKDSILSLYGAGAIQQQGAPGVFMGPTNLPFTSQAPAAFPGFPSMGVPVPAAPGLVGSSLGPSAGMMVGVPVPNGFMGSAQTAVMPLAQGVVGPPGMVAHLGAAQGKFGLQPAPQSPWNLPQVNQQMAGLSLGGAASAAGFGQPPSTSAGAAGWPGGSSGQTLSTQLWK", "length": 493, "header": "tr|A0AAA9SVU7-1|A0AAA9SVU7_BOVIN Isoform 1 of Small ArfGAP 1 OS=Bos taurus OX=9913 GN=SMAP1 PE=4 SV=2 CANONICAL=A0AAA9SVU7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7/entry#A0A3Q1LMH0-1", "sequence": { "sequence": "MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNKEKEKKKEEKKKEKEPEKPTKPLTTEKLQKKEDQQLEPKKSTSPKKAAEPTVDLLGLDGPAEAPVTNGSAVVGPALNDDLDIFGPMISNPLPATVMPPAQGTSSAPAAATLSAVTSGDLDLFTEQAAKSEEVAKKQLSKDSILSLYGAGAIQQQGAPGVFMGPTNLPFTSQAPAAFPGFPSMGVPVPAAPGLVGSSLGPSAGMMVGVPVPNGFMGSAQTAVMPLAQGVVGPPGMVAHLGAAQGKFGLQPAPQSPWNLPQVNQQMAGLSLGGAASAAGFGQPPSTSAGAAGWPGGSSGQTLSTQLWK", "length": 444, "header": "tr|A0A3Q1LMH0-1|A0AAA9SVU7_BOVIN Computationally mapped isoform of Small ArfGAP 1 OS=Bos taurus OX=9913 GN=SMAP1 PE=4 SV=3 CANONICAL=A0AAA9SVU7-1" }, "locus": { "chromosome": "9", "start_pos": 9974221, "end_pos": 9785435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066912.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066912.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057885.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057885.3" } ] } }, { "isoform_ac": "A0A3Q1MPR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7/entry#A0A3Q1MPR9-1", "sequence": { "sequence": "MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNLQKKEDQQLEPKKSTSPKKAAEPTVDLLGLDGPAEAPVTNGSAVVGPALNDDLDIFGPMISNPLPATVMPPAQGTSSAPAAATLSAVTSGDLDLFTEQAAKSEEVAKKQLSKDSILSLYGAGAIQQQGAPGVFMGPTNLPFTSQAPAAFPGFPSMGVPVPAAPGLVGSSLGPSAGMMVGVPVPNGFMGSAQTAVMPLAQGVVGPPGMVAHLGAAQGKFGLQPAPQSPWNLPQVNQQMAGLSLGGAASAAGFGQPPSTSAGAAGWPGGSSGQTLSTQLWK", "length": 417, "header": "tr|A0A3Q1MPR9-1|A0AAA9SVU7_BOVIN Computationally mapped isoform of Small ArfGAP 1 OS=Bos taurus OX=9913 GN=SMAP1 PE=4 SV=1 CANONICAL=A0AAA9SVU7-1" }, "locus": { "chromosome": "9", "start_pos": 9974221, "end_pos": 9785435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067605.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067605.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073918.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073918.1" } ] } }, { "isoform_ac": "A0AAA9SVU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7/entry#A0AAA9SVU7-1", "sequence": { "sequence": "MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQEILVAFERKIENYSGKLQVVVECMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNIASSDAPLQPLVSSPSLQAAVEKNKLEKEKEKKKEEKKKEKEPEKPTKPLTTEKLQKKEDQQLEPKKSTSPKKAAEPTVDLLGLDGPAEAPVTNGSAVVGPALNDDLDIFGPMISNPLPATVMPPAQGTSSAPAAATLSAVTSGDLDLFTEQAAKSEEVAKKQLSKDSILSLYGAGAIQQQGAPGVFMGPTNLPFTSQAPAAFPGFPSMGVPVPAAPGLVGSSLGPSAGMMVGVPVPNGFMGSAQTAVMPLAQGVVGPPGMVAHLGAAQGKFGLQPAPQSPWNLPQVNQQMAGLSLGGAASAAGFGQPPSTSAGAAGWPGGSSGQTLSTQLWK", "length": 493, "header": "tr|A0AAA9SVU7-1|A0AAA9SVU7_BOVIN Isoform 1 of Small ArfGAP 1 OS=Bos taurus OX=9913 GN=SMAP1 PE=4 SV=2 CANONICAL=A0AAA9SVU7-1" }, "locus": { "chromosome": "9", "start_pos": 9974221, "end_pos": 9785435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105553.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105553.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088143.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088143.2" } ] } }, { "isoform_ac": "F1MU99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7/entry#F1MU99-1", "sequence": { "sequence": "MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNFSSVSVAQSCLTPRYPMDCSTPGLPVHHQFSELAETRVHQIASSDAPLQPLVSSPSLQAAVEKNKLELQKKEDQQLEPKKSTSPKKAAEPTVDLLGLDGPAEAPVTNGSAVVGPALNDDLDIFGPMISNPLPATVMPPAQGTSSAPAAATLSAVTSGDLDLFTEQAAKSEEVAKKQLSKDSILSLYGAGAIQQQGAPGVFMGPTNLPFTSQAPAAFPGFPSMGVPVPAAPGLVGSSLGPSAGMMVGVPVPNGFMGSAQTAVMPLAQGVVGPPGMVAHLGAAQGKFGLQPAPQSPWNLPQVNQQMAGLSLGGAASAAGFGQPPSTSAGAAGWPGGSSGQTLSTQLWK", "length": 484, "header": "tr|F1MU99-1|F1MU99_BOVIN Computationally mapped isoform of Small ArfGAP 1 OS=Bos taurus OX=9913 GN=SMAP1 PE=4 SV=4 CANONICAL=A0AAA9SVU7-1" }, "locus": { "chromosome": "9", "start_pos": 9974221, "end_pos": 9785435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053205.5", "url": "https://www.ensembl.org/id/ENSBTAT00000053205.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049158.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049158.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516032", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516032", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ], "pmid": "" }, { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of clathrin-dependent endocytosis", "id": "GO:2000369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000369", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVU7" }, { "id": "PS50115", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arf-GAP", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 158, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 254, "end_pos": 256 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVZ1-1", "uniprot_ac": "A0AAA9SVZ1", "uniprot_id": "A0AAA9SVZ1_BOVIN", "mass": { "chemical_mass": 54556.0, "monoisotopic_mass": 54556.0 }, "refseq": { "ac": "XP_024837567", "name": "BTB/POZ domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837567" }, "gene_names": [ { "name": "BTBD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SVZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" } ] }, { "name": "BTBD1", "type": "synonym", "evidence": [ { "id": "XP_024837567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837567" } ] } ], "protein_names": [ { "name": "BTB domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SVZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024837567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837567" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTBD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1", "locus": { "chromosome": "21", "start_pos": 25046381, "end_pos": 24995357, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021341", "url": "https://www.ensembl.org/id/ENSBTAG00000021341" } ] } } ], "crossref": [ { "id": "A0AAA9SVZ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SVZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021341", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18281", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18281", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525916", "url": "https://www.ncbi.nlm.nih.gov/gene/525916", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MZA8", "url": "https://www.orthodb.org/?gene=F1MZA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45774:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45774:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024837567", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZA8", "url": "https://www.uniprot.org/uniprotkb/F1MZA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZA8-1", "url": "https://www.uniprot.org/uniprotkb/F1MZA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLGPAVTGEQVPGAEAEPGAAGPPPPSTSSLGPLLPLKREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGGGGAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAPCVEFLTKHLRADNAFMLLTQDPQNVTLLGDRVFTEARLFDEPQLASLCLDTIDKNTMDAISAEGFTDIDIDTLCAVLERDTLSIRECRLFGAVVRWAEAECQRQQLPMTFGNKQKVLGKALALIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNLCYMACATLKGPDSHYGTKGLKKVVHETPTASKTVFFFFSSPGNNNGTSIEDGQIPEIIFYT", "length": 497, "header": "tr|A0AAA9SVZ1-1|A0AAA9SVZ1_BOVIN Isoform 1 of BTB domain containing 1 OS=Bos taurus OX=9913 GN=BTBD1 PE=4 SV=2 CANONICAL=A0AAA9SVZ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1/entry#A0AAA9SVZ1-1", "sequence": { "sequence": "MASLGPAVTGEQVPGAEAEPGAAGPPPPSTSSLGPLLPLKREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGGGGAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAPCVEFLTKHLRADNAFMLLTQDPQNVTLLGDRVFTEARLFDEPQLASLCLDTIDKNTMDAISAEGFTDIDIDTLCAVLERDTLSIRECRLFGAVVRWAEAECQRQQLPMTFGNKQKVLGKALALIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNLCYMACATLKGPDSHYGTKGLKKVVHETPTASKTVFFFFSSPGNNNGTSIEDGQIPEIIFYT", "length": 497, "header": "tr|A0AAA9SVZ1-1|A0AAA9SVZ1_BOVIN Isoform 1 of BTB domain containing 1 OS=Bos taurus OX=9913 GN=BTBD1 PE=4 SV=2 CANONICAL=A0AAA9SVZ1-1" }, "locus": { "chromosome": "21", "start_pos": 25045471, "end_pos": 24995454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090911.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090911.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090649.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090649.2" } ] } }, { "isoform_ac": "F1MZA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1/entry#F1MZA8-1", "sequence": { "sequence": "MASLGPAVTGEQVPGAEAEPGAAGPPPPSTSSLGPLLPLKREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGGGGAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAPCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKNTMDAISAEGFTDIDIDTLCAVLERDTLSIRECRLFGAVVRWAEAECQRQQLPMTFGNKQKVLGKALALIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNLCYMACATLKGPDSHYGTKGLKKVVHETPTASKTVFFFFSSPGNNNGTSIEDGQIPEIIFYT", "length": 482, "header": "tr|F1MZA8-1|F1MZA8_BOVIN Computationally mapped isoform of BTB domain containing 1 OS=Bos taurus OX=9913 GN=BTBD1 PE=4 SV=5 CANONICAL=A0AAA9SVZ1-1" }, "locus": { "chromosome": "21", "start_pos": 25045471, "end_pos": 24995454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028446.8", "url": "https://www.ensembl.org/id/ENSBTAT00000028446.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028446.8", "url": "https://www.ensembl.org/id/ENSBTAP00000028446.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVZ1" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 145, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 481, "end_pos": 483 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SU71-1", "uniprot_ac": "A0AAA9SU71", "uniprot_id": "A0AAA9SU71_BOVIN", "mass": { "chemical_mass": 29432.0, "monoisotopic_mass": 29432.0 }, "refseq": {}, "gene_names": [ { "name": "PRXL2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SU71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71" } ] } ], "protein_names": [ { "name": "Peroxiredoxin-like 2A", "type": "recommended", "evidence": [ { "id": "A0AAA9SU71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71/entry#names_and_taxonomy" } ] }, { "name": "Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes", "type": "synonym", "evidence": [ { "id": "A0AAA9SU71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71/entry#names_and_taxonomy" } ] }, { "name": "Redox-regulatory protein FAM213A", "type": "synonym", "evidence": [ { "id": "A0AAA9SU71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71#function" }, { "database": "UniProtKB", "id": "ARBA00059103", "url": "https://www.uniprot.org/uniprotkb/ARBA00059103#function" }, { "database": "UniProtKB", "id": "A0AAA9TRL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL1#function" }, { "database": "UniProtKB", "id": "A0AAA9U2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2L5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRXL2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71", "locus": { "chromosome": "28", "start_pos": 35823873, "end_pos": 35805434, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021416", "url": "https://www.ensembl.org/id/ENSBTAG00000021416" } ] } } ], "crossref": [ { "id": "A0AAA9SU71", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SU71", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02970", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02970", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534049", "url": "https://www.ncbi.nlm.nih.gov/gene/534049", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR28630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28630:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28630:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13911", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13911", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SU71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2L5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSDQNFESGIWETVIPRSRAGSWRLRQVEMSFLQDPSFFGMGMWSIGAGAIGVAALALLLANTDMFLAKPEKAALEYLEDIDLKTLEKDAVTFKAKALWEKNGAVIMAVRRPGCFLCREEATDLSSLKPKLDELGVPLYAVVKEHIKNEVKDFQPYFKGEIFLDENKKFYGPQRRKMMFMGFVRLGVWQNFFRAWNGGFSGNLDGEGFILGGVFVMGPGKQIPHKGCQTIFLQKAFNFKQYFKSFSFKPWVSAVACLRI", "length": 260, "header": "tr|A0AAA9SU71-1|A0AAA9SU71_BOVIN Isoform 1 of Peroxiredoxin-like 2A OS=Bos taurus OX=9913 GN=PRXL2A PE=3 SV=2 CANONICAL=A0AAA9SU71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71/entry#A0AAA9SU71-1", "sequence": { "sequence": "MTSDQNFESGIWETVIPRSRAGSWRLRQVEMSFLQDPSFFGMGMWSIGAGAIGVAALALLLANTDMFLAKPEKAALEYLEDIDLKTLEKDAVTFKAKALWEKNGAVIMAVRRPGCFLCREEATDLSSLKPKLDELGVPLYAVVKEHIKNEVKDFQPYFKGEIFLDENKKFYGPQRRKMMFMGFVRLGVWQNFFRAWNGGFSGNLDGEGFILGGVFVMGPGKQIPHKGCQTIFLQKAFNFKQYFKSFSFKPWVSAVACLRI", "length": 260, "header": "tr|A0AAA9SU71-1|A0AAA9SU71_BOVIN Isoform 1 of Peroxiredoxin-like 2A OS=Bos taurus OX=9913 GN=PRXL2A PE=3 SV=2 CANONICAL=A0AAA9SU71-1" }, "locus": { "chromosome": "28", "start_pos": 35821420, "end_pos": 35806740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089893.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089893.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087564.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087564.2" } ] } }, { "isoform_ac": "A0AAA9TRL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71/entry#A0AAA9TRL1-1", "sequence": { "sequence": "MTSDQNFESGIWETVIPRSRAGSWRLRQVEMSFLQDPSFFGMGMWSIGAGAIGVAALALLLANTDMFLAKPEKAALEYLEDIDLKTLEKDAVTFKAKALWEKNGAVIMAVRRPGCFLCREEATDLSSLKPKLDELGVPLYAVVKEHIKNEVKDFQPYFKGEIFLDENKKFYGPQRRKMMFMGFVRLGVWQNFFRAWNGGFSGNLDGEGFILGGVFVMGPGKQGILLEHREKEFGDKVNLTSVLEAARKIRPQTSASEKQ", "length": 259, "header": "tr|A0AAA9TRL1-1|A0AAA9TRL1_BOVIN Computationally mapped isoform of Peroxiredoxin-like 2A OS=Bos taurus OX=9913 GN=PRXL2A PE=3 SV=1 CANONICAL=A0AAA9SU71-1" }, "locus": { "chromosome": "28", "start_pos": 35823225, "end_pos": 35806740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115274.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115274.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101020.1" } ] } }, { "isoform_ac": "A0AAA9U2L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71/entry#A0AAA9U2L5-1", "sequence": { "sequence": "MGDEMSFLQDPSFFGMGMWSIGAGAIGVAALALLLANTDMFLAKPEKAALEYLEDIDLKTLEKDAVTFKAKALWEKNGAVIMAVRRPGCFLCREEATDLSSLKPKLDELGVPLYAVVKEHIKNEVKDFQPYFKGEIFLDENKKFYGPQRRKMMFMGFVRLGVWQNFFRAWNGGFSGNLDGEGFILGGVFVMGPGKQGILLEHREKEFGDKVNLTSVLEAARKIRPQTSASEKQ", "length": 233, "header": "tr|A0AAA9U2L5-1|A0AAA9U2L5_BOVIN Computationally mapped isoform of Peroxiredoxin-like 2A OS=Bos taurus OX=9913 GN=PRXL2A PE=3 SV=1 CANONICAL=A0AAA9SU71-1" }, "locus": { "chromosome": "28", "start_pos": 35823225, "end_pos": 35811260, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097823.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097823.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103814.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103814.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "antioxidant activity", "id": "GO:0016209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of osteoclast differentiation", "id": "GO:0045670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045670", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9STP8-1", "uniprot_ac": "A0AAA9STP8", "uniprot_id": "A0AAA9STP8_BOVIN", "mass": { "chemical_mass": 30891.0, "monoisotopic_mass": 30891.0 }, "refseq": { "ac": "XP_005220864", "name": "proteasome activator complex subunit 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220864" }, "gene_names": [ { "name": "PSME3", "type": "recommended", "evidence": [ { "id": "A0AAA9STP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ] }, { "name": "PSME3", "type": "synonym", "evidence": [ { "id": "XP_005220864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220864" } ] } ], "protein_names": [ { "name": "Proteasome activator complex subunit 3", "type": "recommended", "evidence": [ { "id": "A0AAA9STP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#names_and_taxonomy" } ] }, { "name": "Activator of multicatalytic protease subunit 3", "type": "synonym", "evidence": [ { "id": "A0AAA9STP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#names_and_taxonomy" } ] }, { "name": "Proteasome activator 28 subunit gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9STP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#names_and_taxonomy" } ] }, { "name": "proteasome activator complex subunit 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005220864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220864" } ] } ], "function": [ { "annotation": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1R8#function" }, { "database": "UniProtKB", "id": "ARBA00037467", "url": "https://www.uniprot.org/uniprotkb/ARBA00037467#function" } ] }, { "annotation": "Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S1R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1R8#function" }, { "database": "UniProtKB", "id": "ARBA00045499", "url": "https://www.uniprot.org/uniprotkb/ARBA00045499#function" }, { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8#function" }, { "database": "UniProtKB", "id": "A0AAA9RUZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUZ6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSME3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8", "locus": { "chromosome": "19", "start_pos": 42865042, "end_pos": 42858763, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019918", "url": "https://www.ensembl.org/id/ENSBTAG00000019918" } ] } } ], "crossref": [ { "id": "A0AAA9STP8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9STP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100336105", "url": "https://www.ncbi.nlm.nih.gov/gene/100336105", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336105", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336105", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMFNERN", "url": "https://omabrowser.org/oma/group/PMFNERN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BM26", "url": "https://www.orthodb.org/?gene=E1BM26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10660", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10660", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10660:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10660:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02251", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02251", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005220864", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220864", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BM26", "url": "https://www.uniprot.org/uniprotkb/E1BM26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BM26-1", "url": "https://www.uniprot.org/uniprotkb/E1BM26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKWILKKIKYLQSGGLSASHYNYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 265, "header": "tr|A0AAA9STP8-1|A0AAA9STP8_BOVIN Isoform 1 of Proteasome activator complex subunit 3 OS=Bos taurus OX=9913 GN=PSME3 PE=3 SV=2 CANONICAL=A0AAA9STP8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#A0AAA9RUZ6-1", "sequence": { "sequence": "MRYKNWEVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 247, "header": "tr|A0AAA9RUZ6-1|A0AAA9STP8_BOVIN Computationally mapped isoform of Proteasome activator complex subunit 3 OS=Bos taurus OX=9913 GN=PSME3 PE=3 SV=1 CANONICAL=A0AAA9STP8-1" }, "locus": { "chromosome": "19", "start_pos": 42864038, "end_pos": 42858943, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122681.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122681.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076046.1" } ] } }, { "isoform_ac": "A0AAA9RXN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#A0AAA9RXN1-1", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 198, "header": "tr|A0AAA9RXN1-1|A0AAA9STP8_BOVIN Computationally mapped isoform of Proteasome activator complex subunit 3 OS=Bos taurus OX=9913 GN=PSME3 PE=3 SV=1 CANONICAL=A0AAA9STP8-1" }, "locus": { "chromosome": "19", "start_pos": 42864038, "end_pos": 42859304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094072.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094072.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078276.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078276.1" } ] } }, { "isoform_ac": "A0AAA9S1R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#A0AAA9S1R8-1", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 231, "header": "tr|A0AAA9S1R8-1|A0AAA9STP8_BOVIN Computationally mapped isoform of Proteasome activator complex subunit 3 OS=Bos taurus OX=9913 GN=PSME3 PE=3 SV=1 CANONICAL=A0AAA9STP8-1" }, "locus": { "chromosome": "19", "start_pos": 42864038, "end_pos": 42859304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103037.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103037.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078970.1" } ] } }, { "isoform_ac": "A0AAA9STP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#A0AAA9STP8-1", "sequence": { "sequence": "MEKWILKKIKYLQSGGLSASHYNYKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 265, "header": "tr|A0AAA9STP8-1|A0AAA9STP8_BOVIN Isoform 1 of Proteasome activator complex subunit 3 OS=Bos taurus OX=9913 GN=PSME3 PE=3 SV=2 CANONICAL=A0AAA9STP8-1" }, "locus": { "chromosome": "19", "start_pos": 42864038, "end_pos": 42859838, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106977.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106977.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088723.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088723.2" } ] } }, { "isoform_ac": "E1BM26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8/entry#E1BM26-1", "sequence": { "sequence": "MNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 193, "header": "tr|E1BM26-1|E1BM26_BOVIN Computationally mapped isoform of Proteasome activator subunit 3 OS=Bos taurus OX=9913 GN=PSME3 PE=3 SV=3 CANONICAL=A0AAA9STP8-1" }, "locus": { "chromosome": "19", "start_pos": 42864038, "end_pos": 42860475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026535.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026535.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026535.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026535.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336105", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336105", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HLZ2-1", "protein_name": "Proteasome activator complex subunit 3", "gene_name": "Psme3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 254 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P43428-1", "protein_name": "Glucose-6-phosphatase catalytic subunit 1", "gene_name": "G6pc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFYVLFPIWFHIQETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRGKKKSTYGFRCLNVVLWLGYWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYCLITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASVSLIPYCLARLLGQTHKKSL", "length": 357 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P61289-1", "protein_name": "Proteasome activator complex subunit 3", "gene_name": "PSME3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 254 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61290-1", "protein_name": "Proteasome activator complex subunit 3", "gene_name": "Psme3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 254 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61291-1", "protein_name": "Proteasome activator complex subunit 3", "gene_name": "PSME3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 254 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5F3J5-1", "protein_name": "Proteasome activator complex subunit 3", "gene_name": "PSME3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASLLKVDPEVKLKVDSFRERITSEAEDLVANFFPKKLLELDGFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPNMKKRKLEDREETFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 254 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q967U1-1", "protein_name": "Proteasome activator 28", "gene_name": "psmE3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKNNSTVIKMDEQVLKYKEDLYEKTVHHLKVTIPKKIAEYQELAKSYGQNSENEQDGQTSKKRKLDSEDYVLMPIEDLIKTNRVIMETHQKFKKAYIELIETFSVIRGWISLNIPRIEDGNNFGVDVQEDIITQITKLEEVYTSLLDGSESYFASRASLVKKILKHKDIEAYRYSLAQVDEKEFTRFSFSYFDLANNYATTYSLIVKNFAKLETPRPTNASNIY", "length": 225 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9V3P3-1", "protein_name": "Proteasome regulator gamma, isoform A", "gene_name": "REG", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPNDTVVKVQEYKDSLILKAELLITKGFPENIVRLNELLATPIFNERNFEEVHQDLNIPVLPPLLVKNELEDRDSLPTKRQRVDVIVSGQPVMGLPAGTVPCNKPLCEMIKVVKPIIRKLVEDSNLLKMWISFMIPKIEDGNNFGVSIQEDTLAEIQTVESEAAAFFDQISRYFLSRAKVVSKVAKYPHIDDYRRAVVELDEKEYLSLWLVVCEVRNRYSSLHDIVIKNLEKLKKPRSSNTESLY", "length": 245 }, "evidence": [ { "id": "A0AAA9STP8", "url": "https://omabrowser.org/oma/group/A0AAA9STP8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "proteasome activator complex", "id": "GO:0008537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" }, { "name": "endopeptidase activator activity", "id": "GO:0061133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061133", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" }, { "name": "MDM2/MDM4 family protein binding", "id": "GO:0097371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097371", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9STP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" }, { "id": "PF02252", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02252" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Proteasome activator PA28 C-terminal", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 262, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9STP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STP8" }, { "id": "PF02251", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02251" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Proteasome activator PA28 N-terminal", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 80, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SVS0-1", "uniprot_ac": "A0AAA9SVS0", "uniprot_id": "A0AAA9SVS0_BOVIN", "mass": { "chemical_mass": 437394.0, "monoisotopic_mass": 437394.0 }, "refseq": { "ac": "NP_001421868", "name": "transformation/transcription domain-associated protein isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421868" }, "gene_names": [ { "name": "TRRAP", "type": "recommended", "evidence": [ { "id": "A0AAA9SVS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ] }, { "name": "TRRAP", "type": "synonym", "evidence": [ { "id": "NP_001421868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421868" } ] } ], "protein_names": [ { "name": "Transformation/transcription domain associated protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SVS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0/entry#names_and_taxonomy" } ] }, { "name": "transformation/transcription domain-associated protein isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001421868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421868" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRRAP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0", "locus": { "chromosome": "25", "start_pos": 37265876, "end_pos": 37353932, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007113", "url": "https://www.ensembl.org/id/ENSBTAG00000007113" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507169", "url": "https://www.ncbi.nlm.nih.gov/gene/507169", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BKJ5", "url": "https://www.orthodb.org/?gene=E1BKJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11139:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11139:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02259", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02259", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20206", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20206", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421868", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKJ5", "url": "https://www.uniprot.org/uniprotkb/E1BKJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKJ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BKJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFLETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIPENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAVEAALPGVPAAPAAPGPAPSPAPVPTPAPPPPPPPTPATPVTPAPVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKESQKLLYVVTEVQGPSVTVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYRRQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERVEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVLTHKGGQRSDGNESISECGRCSLSPFCQFEEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAKPLRDVLAANPNRFITLLLPGGTQTAVRPGSPSTSTLRLDLQFQAVKIISIIVKNEDSWLASQHSLVSQLRRVWVSETFQERHRKENMAATNWKEPKLLAYCLLNYCKKNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPQNYNIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLEPEKQADMLDSLRIYLLQFATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVTSVSSSIKRGLSVDSAQEVKRFRTATGAISTVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTSAAGSPGEVLSRRCVTLLKTALRPDMWAKSELKLQWFDKLLMSVEQPNQVNYGNICTGLEVLSFLLTVLQPPAILSSFKPLQRGVAACMTCGNTKVLRAVHSLLSRLMSLFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATSANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLSPQAASGSTEAASGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKILRSVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIKPKQTAEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSVFMWRQHHYQGKPTWSGMPPPSIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL", "length": 3860, "header": "tr|A0AAA9SVS0-1|A0AAA9SVS0_BOVIN Isoform 1 of Transformation/transcription domain associated protein OS=Bos taurus OX=9913 GN=TRRAP PE=3 SV=1 CANONICAL=A0AAA9SVS0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0/entry#A0AAA9SH40-1", "sequence": { "sequence": "MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFLETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIPENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAVEAALPGVPAAPAAPGPAPSPAPVPTPAPPPPPPPTPATPVTPAPVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKESQKLLYVVTEVQGPSVTVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYRRQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERVEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVLTHKGGQRSDGNESISECGRCSLSPFCQFEPAVEGVEEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAKPLRDVLAANPNRFITLLLPGGTQTAVRPGSPSTSTLRLDLQFQAVKIISIIVKNEDSWLASQHSLVSQLRRVWVSETFQERHRKENMAATNWKEPKLLAYCLLNYCKKNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPQNYNIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLEPEKQADMLDSLRIYLLQFATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVTSVSSSIKRGLSVDSAQEVKRFRTATGAISTVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTSAAGSPGEVLSRRCVTLLKTALRPDMWAKSELKLQWFDKLLMSVEQPNQVNYGNICTGLEVLSFLLTVLQPPAILSSFKPLQRGVAACMTCGNTKVLRAVHSLLSRLMSLFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATSANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLSPQAASGSTEAASGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKILRSVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIKPKQTAEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSVFMWRQHHYQAIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSVGNQSHSASDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL", "length": 3874, "header": "tr|A0AAA9SH40-1|A0AAA9SVS0_BOVIN Computationally mapped isoform of Transformation/transcription domain associated protein OS=Bos taurus OX=9913 GN=TRRAP PE=3 SV=1 CANONICAL=A0AAA9SVS0-1" }, "locus": { "chromosome": "25", "start_pos": 37353871, "end_pos": 37266569, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106438.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106438.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084652.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084652.1" } ] } }, { "isoform_ac": "A0AAA9SVS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0/entry#A0AAA9SVS0-1", "sequence": { "sequence": "MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFLETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIPENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAVEAALPGVPAAPAAPGPAPSPAPVPTPAPPPPPPPTPATPVTPAPVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKESQKLLYVVTEVQGPSVTVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYRRQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERVEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVLTHKGGQRSDGNESISECGRCSLSPFCQFEEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAKPLRDVLAANPNRFITLLLPGGTQTAVRPGSPSTSTLRLDLQFQAVKIISIIVKNEDSWLASQHSLVSQLRRVWVSETFQERHRKENMAATNWKEPKLLAYCLLNYCKKNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPQNYNIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLEPEKQADMLDSLRIYLLQFATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVTSVSSSIKRGLSVDSAQEVKRFRTATGAISTVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTSAAGSPGEVLSRRCVTLLKTALRPDMWAKSELKLQWFDKLLMSVEQPNQVNYGNICTGLEVLSFLLTVLQPPAILSSFKPLQRGVAACMTCGNTKVLRAVHSLLSRLMSLFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATSANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLSPQAASGSTEAASGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKILRSVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIKPKQTAEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSVFMWRQHHYQGKPTWSGMPPPSIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL", "length": 3860, "header": "tr|A0AAA9SVS0-1|A0AAA9SVS0_BOVIN Isoform 1 of Transformation/transcription domain associated protein OS=Bos taurus OX=9913 GN=TRRAP PE=3 SV=1 CANONICAL=A0AAA9SVS0-1" }, "locus": { "chromosome": "25", "start_pos": 37353871, "end_pos": 37266569, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126484.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126484.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089417.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089417.1" } ] } }, { "isoform_ac": "E1BKJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0/entry#E1BKJ5-1", "sequence": { "sequence": "MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFLETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIPENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAVEAALPGVPAAPAAPGPAPSPAPVPTPAPPPPPPPTPATPVTPAPVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITSCKAPGAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKESQKLLYVVTEVQGPSVTVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYRRQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERVEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVLTHKGGQRSDGNEMKICSAIINLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAKPLRDVLAANPNRFITLLLPGGTQTAVRPGSPSTSTLRLDLQFQAVKIISIIVKNEDSWLASQHSLVSQLRRVWVSETFQERHRKENMAATNWKEPKLLAYCLLNYCKKNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPQNYNIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLEPEKQADMLDSLRIYLLQFATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVTSVSSSIKRGLSVDSAQEVKRFRTATGAISTVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTSAAGSPGEVLSRRCVTLLKTALRPDMWAKSELKLQWFDKLLMSVEQPNQVNYGNICTGLEVLSFLLTVLQPPAILSSFKPLQRGVAACMTCGNTKVLRAVHSLLSRLMSLFPTEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATSANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLSPQAASGSTEAASAGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKILRSVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIKPKQTAEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSVFMWRQHHYQAIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDDDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSVGNQSHSASDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL", "length": 3849, "header": "tr|E1BKJ5-1|E1BKJ5_BOVIN Computationally mapped isoform of Transformation/transcription domain associated protein OS=Bos taurus OX=9913 GN=TRRAP PE=3 SV=3 CANONICAL=A0AAA9SVS0-1" }, "locus": { "chromosome": "25", "start_pos": 37353871, "end_pos": 37266569, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009365.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009365.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009365.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009365.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 505, "start_aa": "Thr", "end_pos": 505, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr505", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 515, "start_aa": "Thr", "end_pos": 515, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr515", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 521, "start_aa": "Thr", "end_pos": 521, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr521", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-201722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "resource": "Reactome", "description": "Formation of the beta-catenin:TCF transactivating complex" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex", "id": "GO:0035267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "pmid": "" }, { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "pmid": "" }, { "name": "DNA repair-dependent chromatin remodeling", "id": "GO:0140861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SVS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1083, "end_pos": 1085, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1254, "end_pos": 1256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1396, "end_pos": 1398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1492, "end_pos": 1494, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1729, "end_pos": 1731, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2034, "end_pos": 2036, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2112, "end_pos": 2114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2378, "end_pos": 2380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2385, "end_pos": 2387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2809, "end_pos": 2811, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2862, "end_pos": 2864, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2962, "end_pos": 2964, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3020, "end_pos": 3022, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3134, "end_pos": 3136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3192, "end_pos": 3194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3385, "end_pos": 3387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3388, "end_pos": 3390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3471, "end_pos": 3473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3662, "end_pos": 3664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3735, "end_pos": 3737, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 742, "end_pos": 744, "annotation": "n_glycosylation_sequon" }, { "start_pos": 837, "end_pos": 839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 993, "end_pos": 995, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SVS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" }, { "id": "PS51189", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51189" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAT", "eco_id": "ECO_0000259", "start_pos": 2693, "end_pos": 3276, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SVS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" }, { "id": "PS51190", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51190" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FATC", "eco_id": "ECO_0000259", "start_pos": 3828, "end_pos": 3860, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SVS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVS0" }, { "id": "PS50290", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50290" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PI3K/PI4K catalytic", "eco_id": "ECO_0000259", "start_pos": 3501, "end_pos": 3824, "start_aa": "Met", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 505, 515, 521 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1083, "end_pos": 1085 }, { "start_pos": 1254, "end_pos": 1256 }, { "start_pos": 1396, "end_pos": 1398 }, { "start_pos": 1492, "end_pos": 1494 }, { "start_pos": 1729, "end_pos": 1731 }, { "start_pos": 2034, "end_pos": 2036 }, { "start_pos": 2112, "end_pos": 2114 }, { "start_pos": 2378, "end_pos": 2380 }, { "start_pos": 2385, "end_pos": 2387 }, { "start_pos": 2809, "end_pos": 2811 }, { "start_pos": 2862, "end_pos": 2864 }, { "start_pos": 2962, "end_pos": 2964 }, { "start_pos": 3020, "end_pos": 3022 }, { "start_pos": 3134, "end_pos": 3136 }, { "start_pos": 3192, "end_pos": 3194 }, { "start_pos": 3385, "end_pos": 3387 }, { "start_pos": 3388, "end_pos": 3390 }, { "start_pos": 3471, "end_pos": 3473 }, { "start_pos": 3662, "end_pos": 3664 }, { "start_pos": 3735, "end_pos": 3737 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 742, "end_pos": 744 }, { "start_pos": 837, "end_pos": 839 }, { "start_pos": 993, "end_pos": 995 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZU2-1", "uniprot_ac": "A0AAA9SZU2", "uniprot_id": "A0AAA9SZU2_BOVIN", "mass": { "chemical_mass": 95242.0, "monoisotopic_mass": 95242.0 }, "refseq": { "ac": "NP_001192955", "name": "aryl hydrocarbon receptor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192955" }, "gene_names": [ { "name": "AHR", "type": "recommended", "evidence": [ { "id": "A0AAA9SZU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ] }, { "name": "AHR", "type": "synonym", "evidence": [ { "id": "NP_001192955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192955" } ] } ], "protein_names": [ { "name": "Aryl hydrocarbon receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SZU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2/entry#names_and_taxonomy" } ] }, { "name": "aryl hydrocarbon receptor", "type": "synonym", "evidence": [ { "id": "NP_001192955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192955" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AHR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2", "locus": { "chromosome": "4", "start_pos": 25855901, "end_pos": 25696360, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007746", "url": "https://www.ensembl.org/id/ENSBTAG00000007746" } ] } } ], "crossref": [ { "id": "A0AAA9SZU2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007746", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007746", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11436", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11436", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "280714", "url": "https://www.ncbi.nlm.nih.gov/gene/280714", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:280714", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280714", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1ML85", "url": "https://www.orthodb.org/?gene=F1ML85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10649", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10649", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10649:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10649:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08447", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08447", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-211945", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211945", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-211976", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211976", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211981", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8937144", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937144", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192955", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML85", "url": "https://www.uniprot.org/uniprotkb/F1ML85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML85-1", "url": "https://www.uniprot.org/uniprotkb/F1ML85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSSSANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPPDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPADRNGVQDNCRTKFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPQQCPDSGQRIDEANGLSQPAVYYNPDQIPPENSSFMERCFVCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPTGCDAKGKLVLGYTEAELSMRGSGYQFVHAADMLYCAEYHIRMIKTGESGMIVFRLLTKDNRWAWVQSNARLVYKNGRPDYIIATQRPLTDEEGMEHLNKRNMKLPFMFTTGDAILYEISNPFPSVMDPLPIKTKNGAGGKESTTTSALSKDSLNPSSLLNAMMQQDEAIYLYPASTSTPFERNFFSDSLNECSNWQNNVVPMGSDSILKHEQISQSQDMNPTLSGDHTGLFADNRNSDLYNIMKHLGIDFEDIEHMQQNEEFFRTDFSGEDDFRDIDLTDEILTYVEDSLNKPAFGCSGYPQQPSMALNPSCMVQEQLQLDQQQLQPHQRHTTVEQQQQLCQKMKHMQVNSMFANWNANQSVPLNCPQQDLQQYVFADLPGTSQEFPYKPELDPMPYPQNLIPYSQPGLPPQPQGAQLDFPMGDFEPAPYPTTASNLEDFVSCLQVPENQQHGLNPQSAMVAPQTCYAGAVSMYQCQPDPQHSQLAQMQYNPTTPGSQAVVNKFQNGAILNETYPAELNSMRNTEPATRLHPSEARPYPDLTSSGFL", "length": 844, "header": "tr|A0AAA9SZU2-1|A0AAA9SZU2_BOVIN Isoform 1 of Aryl hydrocarbon receptor OS=Bos taurus OX=9913 GN=AHR PE=4 SV=2 CANONICAL=A0AAA9SZU2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2/entry#A0AAA9SQX0-1", "sequence": { "sequence": "MNSSSANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPPDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPADRNGVQDNCRTKFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPQQCPDSGQRIDEANGLSQPAVYYNPDQIPPENSSFMERCFVCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPTGCDAKGKLVLGYTEAELSMRGSGYQFVHAADMLYCAEYHIRMIKTGESGMIVFRLLTKDNRWAWVQSNARLVYKNGRPDYIIATQRPLTDEEGMEHLNKRNMKLPFMFTTGDAILYEISNPFPSVMDPLPIKTKNGAGGKESTTTSALSKDSLNPSSLLNAMMQQDEAIYLYPASTSTPFERNFFSDSLNECSNWQNNVVPMGSDSILKHEQISQSQDMNPTLSGDHTGLFADNRNSDLYNIMKHLGIDFEDIEHMQQNEEFFRTDFSGEDDFRDIDLTDEILTYVEDSLNKPAFGCSGYPQQPSMALNPSCMVQEQLQLDQQQLQPHQRHTTVEQQQQLCQKMKHMQVNSMFANWNANQSVPLNCPQQDLQQYVFADLPGTSQEFPYKPELDPMPYPQNLIPYSQPGLPPQPQGAQLDFPMGDFEPAPYPTTASNLEDFVSCLQVPENQQHGLNPQSAMVAPQTCYAGAVSMYQCQPDPQHSQLAQMQYNPTTPGSQAVVNKKKTVKTFLILIPDIVQLY", "length": 818, "header": "tr|A0AAA9SQX0-1|A0AAA9SZU2_BOVIN Computationally mapped isoform of Aryl hydrocarbon receptor OS=Bos taurus OX=9913 GN=AHR PE=4 SV=1 CANONICAL=A0AAA9SZU2-1" }, "locus": { "chromosome": "4", "start_pos": 25853458, "end_pos": 25805843, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100896.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100896.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088733.1" } ] } }, { "isoform_ac": "A0AAA9SZU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2/entry#A0AAA9SZU2-1", "sequence": { "sequence": "MNSSSANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPPDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPADRNGVQDNCRTKFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPQQCPDSGQRIDEANGLSQPAVYYNPDQIPPENSSFMERCFVCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPTGCDAKGKLVLGYTEAELSMRGSGYQFVHAADMLYCAEYHIRMIKTGESGMIVFRLLTKDNRWAWVQSNARLVYKNGRPDYIIATQRPLTDEEGMEHLNKRNMKLPFMFTTGDAILYEISNPFPSVMDPLPIKTKNGAGGKESTTTSALSKDSLNPSSLLNAMMQQDEAIYLYPASTSTPFERNFFSDSLNECSNWQNNVVPMGSDSILKHEQISQSQDMNPTLSGDHTGLFADNRNSDLYNIMKHLGIDFEDIEHMQQNEEFFRTDFSGEDDFRDIDLTDEILTYVEDSLNKPAFGCSGYPQQPSMALNPSCMVQEQLQLDQQQLQPHQRHTTVEQQQQLCQKMKHMQVNSMFANWNANQSVPLNCPQQDLQQYVFADLPGTSQEFPYKPELDPMPYPQNLIPYSQPGLPPQPQGAQLDFPMGDFEPAPYPTTASNLEDFVSCLQVPENQQHGLNPQSAMVAPQTCYAGAVSMYQCQPDPQHSQLAQMQYNPTTPGSQAVVNKFQNGAILNETYPAELNSMRNTEPATRLHPSEARPYPDLTSSGFL", "length": 844, "header": "tr|A0AAA9SZU2-1|A0AAA9SZU2_BOVIN Isoform 1 of Aryl hydrocarbon receptor OS=Bos taurus OX=9913 GN=AHR PE=4 SV=2 CANONICAL=A0AAA9SZU2-1" }, "locus": { "chromosome": "4", "start_pos": 25855469, "end_pos": 25805843, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118207.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118207.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090943.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090943.2" } ] } }, { "isoform_ac": "F1ML85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2/entry#F1ML85-1", "sequence": { "sequence": "MAVFEGERNLVDFSIGNHIPQMHEVWKSVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPPDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPADRNGVQDNCRTKFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPQQCPDSGQRIDEANGLSQPAVYYNPDQIPPENSSFMERCFVCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPTGCDAKGKLVLGYTEAELSMRGSGYQFVHAADMLYCAEYHIRMIKTGESGMIVFRLLTKDNRWAWVQSNARLVYKNGRPDYIIATQRPLTDEEGMEHLNKRNMKLPFMFTTGDAILYEISNPFPSVMDPLPIKTKNGAGGKESTTTSALSKDSLNPSSLLNAMMQQDEAIYLYPASTSTPFERNFFSDSLNECSNWQNNVVPMGSDSILKHEQISQSQDMNPTLSGDHTGLFADNRNSDLYNIMKHLGIDFEDIEHMQQNEEFFRTDFSGEDDFRDIDLTDEILTYVEDSLNKPAFGCSGYPQQPSMALNPSCMVQEQLQLDQQQLQPHQRHTTVEQQQQLCQKMKHMQVNSMFANWNANQSVPLNCPQQDLQQYVFADLPGTSQEFPYKPELDPMPYPQNLIPYSQPGLPPQPQGAQLDFPMGDFEPAPYPTTASNLEDFVSCLQVPENQQHGLNPQSAMVAPQTCYAGAVSMYQCQPDPQHSQLAQMQYNPTTPGSQAVVNKFQNGAILNETYPAELNSMRNTEPATRLHPSEARPYPDLTSSGFL", "length": 850, "header": "tr|F1ML85-1|A0AAA9SZU2_BOVIN Computationally mapped isoform of Aryl hydrocarbon receptor OS=Bos taurus OX=9913 GN=AHR PE=4 SV=2 CANONICAL=A0AAA9SZU2-1" }, "locus": { "chromosome": "4", "start_pos": 25855469, "end_pos": 25816740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010187.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010187.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010187.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010187.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 729, "start_aa": "Thr", "end_pos": 729, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr729", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:280714", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280714", "resource": "KEGG Pathway" }, { "id": "R-BTA-211945", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211945", "resource": "Reactome", "description": "Phase I - Functionalization of compounds" }, { "id": "R-BTA-211976", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211976", "resource": "Reactome", "description": "Endogenous sterols" }, { "id": "R-BTA-211981", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211981", "resource": "Reactome", "description": "Xenobiotics" }, { "id": "R-BTA-8937144", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937144", "resource": "Reactome", "description": "Aryl hydrocarbon receptor signalling" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "TFIID-class transcription factor complex binding", "id": "GO:0001094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "TBP-class protein binding", "id": "GO:0017025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "Hsp90 protein binding", "id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "aryl hydrocarbon receptor complex", "id": "GO:0034751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034751", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "nuclear aryl hydrocarbon receptor complex", "id": "GO:0034753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034753", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cellular response to 2,3,7,8-tetrachlorodibenzodioxine", "id": "GO:1904613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904613", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cellular response to forskolin", "id": "GO:1904322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904322", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "response to toxic substance", "id": "GO:0009636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "regulation of B cell proliferation", "id": "GO:0030888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "cellular response to molecule of bacterial origin", "id": "GO:0071219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" }, { "name": "negative regulation of T cell mediated immune response to tumor cell", "id": "GO:0002841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002841", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 656, "end_pos": 658, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 80, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SZU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU2" }, { "id": "PS50112", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50112" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PAS", "eco_id": "ECO_0000259", "start_pos": 110, "end_pos": 180, "start_aa": "Asn", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 729 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 211, "end_pos": 213 }, { "start_pos": 229, "end_pos": 231 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 656, "end_pos": 658 }, { "start_pos": 7, "end_pos": 9 }, { "start_pos": 808, "end_pos": 810 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYP4-1", "uniprot_ac": "A0AAA9SYP4", "uniprot_id": "A0AAA9SYP4_BOVIN", "mass": { "chemical_mass": 43697.0, "monoisotopic_mass": 43697.0 }, "refseq": {}, "gene_names": [ { "name": "NR1H3", "type": "recommended", "evidence": [ { "id": "A0AAA9SYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ] } ], "protein_names": [ { "name": "Nuclear receptor subfamily 1 group H member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NR1H3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4", "locus": { "chromosome": "15", "start_pos": 77138814, "end_pos": 77131483, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010681", "url": "https://www.ensembl.org/id/ENSBTAG00000010681" } ] } } ], "crossref": [ { "id": "A0AAA9SYP4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24082:SF259", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24082:SF259", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLWLEAPVPDVSPDSAVELWEPDAQDASSQPLGSSKCILREESSTPQSAGDTSRMGLEAPEPTALLPGVEAPPESTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKMKRQEEEQAQATSAPPRASSPPQVLPQLSPEQLGMIEKLVAAQQLCNRRSFSDQLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE", "length": 387, "header": "tr|A0AAA9SYP4-1|A0AAA9SYP4_BOVIN Isoform 1 of Nuclear receptor subfamily 1 group H member 3 OS=Bos taurus OX=9913 GN=NR1H3 PE=3 SV=1 CANONICAL=A0AAA9SYP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4/entry#A0AAA9SYP4-1", "sequence": { "sequence": "MSLWLEAPVPDVSPDSAVELWEPDAQDASSQPLGSSKCILREESSTPQSAGDTSRMGLEAPEPTALLPGVEAPPESTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKMKRQEEEQAQATSAPPRASSPPQVLPQLSPEQLGMIEKLVAAQQLCNRRSFSDQLRVTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE", "length": 387, "header": "tr|A0AAA9SYP4-1|A0AAA9SYP4_BOVIN Isoform 1 of Nuclear receptor subfamily 1 group H member 3 OS=Bos taurus OX=9913 GN=NR1H3 PE=3 SV=1 CANONICAL=A0AAA9SYP4-1" }, "locus": { "chromosome": "15", "start_pos": 77138487, "end_pos": 77132432, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128824.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128824.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089381.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089381.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 387, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYP4" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 170, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWW3-1", "uniprot_ac": "A0AAA9SWW3", "uniprot_id": "A0AAA9SWW3_BOVIN", "mass": { "chemical_mass": 66537.0, "monoisotopic_mass": 66537.0 }, "refseq": {}, "gene_names": [ { "name": "LOC529992", "type": "recommended", "evidence": [ { "id": "A0AAA9SWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ] }, { "name": "VBP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ] }, { "name": "LOC529992", "type": "synonym", "evidence": [ { "id": "A0AAA9SWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ] } ], "protein_names": [ { "name": "Prefoldin subunit 3", "type": "recommended", "evidence": [ { "id": "A0AAA9SWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#names_and_taxonomy" } ] }, { "name": "von Hippel-Lindau-binding protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SD64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD64#function" }, { "database": "UniProtKB", "id": "PIRNR016396", "url": "https://www.uniprot.org/uniprotkb/PIRNR016396#function" }, { "database": "UniProtKB", "id": "ARBA00024667", "url": "https://www.uniprot.org/uniprotkb/ARBA00024667#function" }, { "database": "UniProtKB", "id": "A0AAA9SV73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV73#function" }, { "database": "UniProtKB", "id": "A0AAA9TJR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR6#function" }, { "database": "UniProtKB", "id": "G5E5K1", "url": "https://www.uniprot.org/uniprotkb/G5E5K1#function" }, { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3#function" }, { "database": "UniProtKB", "id": "A0AAA9TXX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXX2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC529992", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SWW3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017265", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017265", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G5E5K1", "url": "https://www.orthodb.org/?gene=G5E5K1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12409", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12409", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12409:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12409:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22951", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22951", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22951:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22951:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SD64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5K1", "url": "https://www.uniprot.org/uniprotkb/G5E5K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5K1-1", "url": "https://www.uniprot.org/uniprotkb/G5E5K1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSSASKAALGATTNEPTEPEQKHLADLIQYINGTNMSVVHLADVLSEKTGSSSWVVVFKALVTVHHLMVYGNERFIQHLASRSSLFTLHNFLDKSVVEGYAMSAFIRRYSKYLNEKSLAYRLMESDITKIKRGADGVMRTMNTKELLNTLPVIQIQFDALLNFNANADELTNGIIHAAFMLLFKDSLRLFVAYNEGILNLLDKYFDMGKKQCRESLDIYIKFLDRMTKLAQFLKVAEQAGIDPNDIPYVSQAPYSLLEALKQHLASLEDKHDILPPYGMQRALIPSIPNSPVVRTSASKVRFSARKHVEARQQNEKVIANDLDGSVVSLVENLNFGESAVNRSDVKWRHPSEMEMTSDMNWQLSNCTCISTIWDPVSVSSISYMVPTPVRLPSVMAPQSMSYTQPGLRTSKACAAPTRNNEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA", "length": 587, "header": "tr|A0AAA9SWW3-1|A0AAA9SWW3_BOVIN Isoform 1 of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=LOC529992 PE=3 SV=1 CANONICAL=A0AAA9SWW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#A0AAA9SD64-1", "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEAPSGCCVENRLWKQGDQ", "length": 190, "header": "tr|A0AAA9SD64-1|A0AAA9SWW3_BOVIN Computationally mapped isoform of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=LOC529992 PE=3 SV=1 CANONICAL=A0AAA9SWW3-1" }, "locus": { "chromosome": "X", "start_pos": 35812798, "end_pos": 35773136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126968.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126968.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084056.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084056.1" } ] } }, { "isoform_ac": "A0AAA9SV73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#A0AAA9SV73-1", "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVRWTSRLLPCLGYCKQCCDEHWGTHISLILVSSVCMPSSGIAGSYGSFLLCFPPPSPSHSLCHEFTESHFLFLFLWL", "length": 250, "header": "tr|A0AAA9SV73-1|A0AAA9SWW3_BOVIN Computationally mapped isoform of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=LOC529992 PE=3 SV=1 CANONICAL=A0AAA9SWW3-1" }, "locus": { "chromosome": "X", "start_pos": 35812798, "end_pos": 35790217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088082.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088082.1" } ] } }, { "isoform_ac": "A0AAA9SWW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#A0AAA9SWW3-1", "sequence": { "sequence": "MGSSASKAALGATTNEPTEPEQKHLADLIQYINGTNMSVVHLADVLSEKTGSSSWVVVFKALVTVHHLMVYGNERFIQHLASRSSLFTLHNFLDKSVVEGYAMSAFIRRYSKYLNEKSLAYRLMESDITKIKRGADGVMRTMNTKELLNTLPVIQIQFDALLNFNANADELTNGIIHAAFMLLFKDSLRLFVAYNEGILNLLDKYFDMGKKQCRESLDIYIKFLDRMTKLAQFLKVAEQAGIDPNDIPYVSQAPYSLLEALKQHLASLEDKHDILPPYGMQRALIPSIPNSPVVRTSASKVRFSARKHVEARQQNEKVIANDLDGSVVSLVENLNFGESAVNRSDVKWRHPSEMEMTSDMNWQLSNCTCISTIWDPVSVSSISYMVPTPVRLPSVMAPQSMSYTQPGLRTSKACAAPTRNNEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA", "length": 587, "header": "tr|A0AAA9SWW3-1|A0AAA9SWW3_BOVIN Isoform 1 of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=LOC529992 PE=3 SV=1 CANONICAL=A0AAA9SWW3-1" }, "locus": { "chromosome": "X", "start_pos": 35863101, "end_pos": 35789118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092855.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092855.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087738.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087738.1" } ] } }, { "isoform_ac": "A0AAA9TJR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#A0AAA9TJR6-1", "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVTGLSLRLLLAAVWRIDSGSREISDHNNRGNK", "length": 205, "header": "tr|A0AAA9TJR6-1|A0AAA9TJR6_BOVIN Computationally mapped isoform of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=LOC529992 PE=3 SV=1 CANONICAL=A0AAA9SWW3-1" }, "locus": { "chromosome": "X", "start_pos": 35812798, "end_pos": 35773111, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096808.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096808.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097396.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097396.1" } ] } }, { "isoform_ac": "A0AAA9TXX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#A0AAA9TXX2-1", "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVSGHTTNCGKLMGPNILLGEIQITSDHRENCSPVGLTNGEGNGTPLQYSCLENPMNGGAW", "length": 233, "header": "tr|A0AAA9TXX2-1|A0AAA9TXX2_BOVIN Computationally mapped isoform of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=LOC529992 PE=3 SV=1 CANONICAL=A0AAA9SWW3-1" }, "locus": { "chromosome": "X", "start_pos": 35812798, "end_pos": 35783675, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089122.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089122.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103190.1" } ] } }, { "isoform_ac": "G5E5K1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3/entry#G5E5K1-1", "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVSVAINLLNFRSS", "length": 186, "header": "tr|G5E5K1-1|G5E5K1_BOVIN Computationally mapped isoform of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=VBP1 PE=3 SV=2 CANONICAL=A0AAA9SWW3-1" }, "locus": { "chromosome": "X", "start_pos": 35812798, "end_pos": 35785749, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022946.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022946.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022946.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022946.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "prefoldin complex", "id": "GO:0016272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016272", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "clathrin coat assembly", "id": "GO:0048268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis", "id": "GO:0072583", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072583", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "tubulin complex assembly", "id": "GO:0007021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "microtubule-based process", "id": "GO:0007017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "1-phosphatidylinositol binding", "id": "GO:0005545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005545", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW3" }, { "id": "PS50942", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50942" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ENTH", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 128, "start_aa": "Met", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 433, "end_pos": 435 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SY50-1", "uniprot_ac": "A0AAA9SY50", "uniprot_id": "A0AAA9SY50_BOVIN", "mass": { "chemical_mass": 71717.0, "monoisotopic_mass": 71717.0 }, "refseq": {}, "gene_names": [ { "name": "OR4S1", "type": "recommended", "evidence": [ { "id": "A0AAA9SY50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 4 subfamily X member 17", "type": "synonym", "evidence": [ { "id": "A0AAA9SY50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SLT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLT2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" }, { "database": "UniProtKB", "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50#function" }, { "database": "UniProtKB", "id": "A0AAA9T5L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L3#function" }, { "database": "UniProtKB", "id": "A0AAA9TKL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL5#function" }, { "database": "UniProtKB", "id": "A0A3Q1MF68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF68#function" }, { "database": "UniProtKB", "id": "A0AAA9TJZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJZ2#function" }, { "database": "UniProtKB", "id": "A0AAA9TYL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL9#function" }, { "database": "UniProtKB", "id": "A0ABI0P624", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P624#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4S1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50", "locus": {} } ], "crossref": [ { "id": "A0AAA9SY50", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SY50", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000055007", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000055007", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510451", "url": "https://www.ncbi.nlm.nih.gov/gene/510451", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510451", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510451", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TGRCKAL", "url": "https://omabrowser.org/oma/group/TGRCKAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "WVGAFVH", "url": "https://omabrowser.org/oma/group/WVGAFVH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MF68", "url": "https://www.orthodb.org/?gene=A0A3Q1MF68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MF68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P624", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P624", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P624-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P624-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAKNNLTEFVLLGLFRSQEMQRACFLVFSLFHVLTVLGNLLVIVTINASKTLHAPMYFFLCHLSFADMCYPSASTPKMIADTLVERKTISFKGCMTQLFSAHFFGGTEIFLLTAMAYDRYVAICRPLHYETIMGRRKCGLLAGASWVAGFLHSILQTLLTVQLPFCGPNEIDSFFCDVHPLLKLACADTYVVGLIVVANSGMISLVSFIILIISYVVILLNLRSRSSESQRKALSTCGSHIIAVLLVLVPPMFMYIRPSTTLAADKLVILFNIVMPPLLNPLIYTLRNSEFCQENALVIANTLFQQYTWTSSDDQHQNQIDYILCSQRWRSSIQSTKTGPGADYGSDHELLIAKFRLKLKKIGKTNRPFRYDLNQIPYDYTVEVRNRFKGLDLIDRVPDELWTEVCDIVQETGIKTIPMEKKCKKARWLSGEALQIAVKRREAKSKGEKERYKHLNVEFQRIARKAKKAFLSDQCKEIEENNRMGKTRDLFKKIRDTKGTFHAKMGSIKDRNGMDLTEAEDIKKRWQEYTEELYKKDLHDPDNHDGVITHLEPDILECEVKWALESITNKASGGDGIPVELFQILKDDAVKVLHSICQKIWKPQQWPQDWKRSPIEIPASWWLHHG", "length": 627, "header": "tr|A0AAA9SY50-1|A0AAA9SY50_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily X member 17 OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=2 CANONICAL=A0AAA9SY50-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MF68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0A3Q1MF68-1", "sequence": { "sequence": "MSCSRTLLQTYHPSKFLPPGGCIMAKTHNVTEFIFLGLSSNPEVQKVCFVMFLLLYTATVLGNFLIVLTVRSSRTLGSPMYFFLSYLSFVEICYASTTVPRLISDLLAERKAIPLWGCMSQVFFIHFFGGIEMFLLTVMAYDRYVAICKPLSYTTIMSRQACALLVGAAWVGGFVHSLAQILLIFHLPFCGPNVIDHYFCDVLPLLKLACSDTVLIGLLVVANGGTLSVISFVVLLASYVVILLHLRTRSSTGRCKALSTCGAHVTVVTLFFGPCIFIYLRPSTTLSVDKTVAIFYTVITPLLNPVIYSLRNAEVKKAVRRLWVRAIKLEER", "length": 332, "header": "tr|A0A3Q1MF68-1|A0A3Q1MF68_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=3 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78006944, "end_pos": 77959111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083410.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083410.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067554.3", "url": "https://www.ensembl.org/id/ENSBTAP00000067554.3" } ] } }, { "isoform_ac": "A0AAA9SLT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0AAA9SLT2-1", "sequence": { "sequence": "MAKTHNVTEFIFLGLSSNPEVQKVCFVMFLLLYTAIVLGNLLIVLTVMSSRSLGSPMYFFLSYLSFVEICYASTTVPRLISDLLAERKAISLWGCMTQLSFLHFFAGTEIFLLTVMAYDRYVAICKPLSYTTIMNRRVCAFLVGAAWVWGLVHSLAQILLIFRLPFCGPNVIDHYFCDVLPLLKLACSDTVLIGLLIVANGGTLSVISFVVLLASYVVILLHLRTWSSAGRRKALSTCGSHITVVTLFFGPCIFIYLRPSTTLSVDKTVAVFYTVITPLLNPVIYSLRNAEVKKAMKRLWVRAMKLEERQVLYHQHHLGSAAARPHTPARSQTREETAIKPGRSPGVLRAPASPPWARVHLQQGGDGHCTQGKLCLQATEHTDCTELLPQKDMLSRLA", "length": 398, "header": "tr|A0AAA9SLT2-1|A0AAA9SY50_BOVIN Computationally mapped isoform of Olfactory receptor family 4 subfamily X member 17 OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=1 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78032225, "end_pos": 78006018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089467.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089467.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087312.1" } ] } }, { "isoform_ac": "A0AAA9SY50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0AAA9SY50-1", "sequence": { "sequence": "MGAKNNLTEFVLLGLFRSQEMQRACFLVFSLFHVLTVLGNLLVIVTINASKTLHAPMYFFLCHLSFADMCYPSASTPKMIADTLVERKTISFKGCMTQLFSAHFFGGTEIFLLTAMAYDRYVAICRPLHYETIMGRRKCGLLAGASWVAGFLHSILQTLLTVQLPFCGPNEIDSFFCDVHPLLKLACADTYVVGLIVVANSGMISLVSFIILIISYVVILLNLRSRSSESQRKALSTCGSHIIAVLLVLVPPMFMYIRPSTTLAADKLVILFNIVMPPLLNPLIYTLRNSEFCQENALVIANTLFQQYTWTSSDDQHQNQIDYILCSQRWRSSIQSTKTGPGADYGSDHELLIAKFRLKLKKIGKTNRPFRYDLNQIPYDYTVEVRNRFKGLDLIDRVPDELWTEVCDIVQETGIKTIPMEKKCKKARWLSGEALQIAVKRREAKSKGEKERYKHLNVEFQRIARKAKKAFLSDQCKEIEENNRMGKTRDLFKKIRDTKGTFHAKMGSIKDRNGMDLTEAEDIKKRWQEYTEELYKKDLHDPDNHDGVITHLEPDILECEVKWALESITNKASGGDGIPVELFQILKDDAVKVLHSICQKIWKPQQWPQDWKRSPIEIPASWWLHHG", "length": 627, "header": "tr|A0AAA9SY50-1|A0AAA9SY50_BOVIN Isoform 1 of Olfactory receptor family 4 subfamily X member 17 OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=2 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78006022, "end_pos": 77971869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123225.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123225.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089173.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089173.2" } ] } }, { "isoform_ac": "A0AAA9T5L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0AAA9T5L3-1", "sequence": { "sequence": "MSCSRTLLQTYHPLKFLPPGGYIMAKTHNVTEFIFLGLSSNPEVQKVCFVMFLLLYTAIVLGNLLIVLTVMSSRSLGSPMYFFLSYLSFVEICYASTTVPRLISDLLAERKAISLWGCMTQLSFLHFFAGTEIFLLTVMAYDRYVAICKPLSYTTIMNRRVCAFLVGAAWVWGLVHSLAQILLIFRLPFCGPNVIDHYFCDVLPLLKLACSDTVLIGLLIVANGGTLSVISFVVLLASYVVILLHLRTWSSAGRRKALSTCGSHITVVTLFFGPCIFIYLRPSTTLSVDKTVAVFYTVITPLLNPVIYSLRNAEVKKAMKRLWVRAMKLEER", "length": 332, "header": "tr|A0AAA9T5L3-1|A0AAA9T5L3_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=1 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78029513, "end_pos": 77959111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114315.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114315.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092014.1" } ] } }, { "isoform_ac": "A0AAA9TJZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0AAA9TJZ2-1", "sequence": { "sequence": "MAKTHNVTEFIFLGLSSNPEVQKVCFVMFLLLYTAIVLGNLLIVLTVMSSRSLGSPMYFFLSYLSFVEICYASTTVPKLISDLLAERKAIPLWGCMSQFFFIHLFGGTEAFLLTVMAYDRYVAICKPLSYTTIMSRQACAFLVGAAWVGAFVHSLVDSLLVFRLPFCGPNVIDHYFCDVLPLLKLACSDTVLIGLLIVANGGTLSVISFVVLLASYVVILLHLRTRSSAGRRKALSTCGSHVTVVTLFFGPCIFIYLRPSTTLSVDKTVAVFYTVITPLLNPVIYSLRNAEVKKAMKRLWVRAMKLEER", "length": 309, "header": "tr|A0AAA9TJZ2-1|A0AAA9TJZ2_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=1 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78029513, "end_pos": 77992130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097154.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097154.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097496.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097496.1" } ] } }, { "isoform_ac": "A0AAA9TKL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0AAA9TKL5-1", "sequence": { "sequence": "MSCSRTLLQTYHPSKFLPPGGCIMAKTHNVTEFIFLGLSSNPEVQKVCFVMFLLLYTAIVLGNLLIVLTVMSSRSLGSPMYFFLSYLSFVEICYASTTVPKLISDLLAERKAIPLWGCMSQFFFIHLFGGTEAFLLTVMAYDRYVAICKPLSYTTIMSRQACAFLVGAAWVGAFVHSLVDSLLVFRLPFCGPNVIDHYFCDVLPLLKLACSDTVLIGLLIVANGGTLSVISFVVLLASYVVILLHLRTRSSAGRRKALSTCGSHVTVVTLFFGPCIFIYLRPSTTLSVDKTVAVFYTVITPLLNPVIYSLRNAEVKKAMKRLWVRAMKLEERSPIEIPASWWLHHG", "length": 346, "header": "tr|A0AAA9TKL5-1|A0AAA9TKL5_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=1 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78006022, "end_pos": 77959111, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125216.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125216.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097730.1" } ] } }, { "isoform_ac": "A0AAA9TYL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0AAA9TYL9-1", "sequence": { "sequence": "MAKTHNVTEFIFLGLSSNPEVQKVCFVMFLLLYTATVLGNFLIVLTVRSSRTLGSPMYFFLSYLSFVEICYASTTVPRLISDLLAERKAIPLWGCMSQVFFIHFFGGIEMFLLTVMAYDRYVAICKPLSYTTIMSRQACALLVGAAWVGGFVHSLAQILLIFHLPFCGPNVIDHYFCDVLPLLKLACSDTVLIGLLVVANGGTLSVISFVVLLASYVVILLHLRTRSSTGRCKALSTCGAHVTVVTLFFGPCIFIYLRPSTTLSVDKTVAIFYTVITPLLNPVIYSLRNAEVKKAVRRLWVRAIKLEER", "length": 309, "header": "tr|A0AAA9TYL9-1|A0AAA9TYL9_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=1 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 78006944, "end_pos": 78006018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126707.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126707.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102603.1" } ] } }, { "isoform_ac": "A0ABI0P624-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50/entry#A0ABI0P624-1", "sequence": { "sequence": "MGAKNNLTEFVLLGLFRSQEMQRACFLVFSLFHVLTVLGNLLVIVTINASKTLHAPMYFFLCHLSFADMCYPSASTPKMIADTLVERKTISFKGCMTQLFSAHFFGGTEIFLLTAMAYDRYVAICRPLHYETIMGRRKCGLLAGASWVAGFLHSILQTLLTVQLPFCGPNEIDSFFCDVHPLLKLACADTYVVGLIVVANSGMISLVSFIILIISYVVILLNLRSRSSESQRKALSTCGSHIIAVLLVLVPPMFMYIRPSTTLAADKLVILFNIVMPPLLNPLIYTLRNSEVKNAMRKIFRVKGSSRREVKLQGFS", "length": 316, "header": "tr|A0ABI0P624-1|A0ABI0P624_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4S1 PE=3 SV=1 CANONICAL=A0AAA9SY50-1" }, "locus": { "chromosome": "15", "start_pos": 77972816, "end_pos": 77971869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106419.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510451", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510451", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JUH0-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADLFNVTEFIFLGLSPNKEVQRVCFVLFLLLYMAIVLGNLLMVVTVAVSRNLGSPMYFFLSSLSFVEICYSSTTAPKLILDLLAEKKSISVWGCMTQLFFLHYFGGIEIFLLTVMAYDRYVAICKPLHYTSIMNRKVCIVLVGTAWTGGFVHSFAQIVLIFPLPFCGPNTIDHYFCDVLPLLKLACSDTFLIGLLIVANAGTLSVISFVVLLASYVVILFHLRTQSAEGRRKALSTCGSHVTVVILFFGPCVFIYSRPSDTLPVDKIIAVFYTVITPLLNPLIYSLRSAEVKKAMKDLWFRTMKADEK", "length": 309 }, "evidence": [ { "id": "A0AAA9SY50", "url": "https://omabrowser.org/oma/group/A0AAA9SY50/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A5G2QSG3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100523167", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANTHNVTEFIFLGLFPNLKVQKVCFVIFLLLYTAIVLGNFIIVLTVMTSRSLGSPMYFFLSSLSFVEICYSSTTTPKLISDLLADRKAISLWGCMSQVFFIHFFGGVEMFLLTVMAYDRYVAICKPLNYITIMNRQVCAFLVGVAGAGGFVHSSAQILLIFRLPFCGPNVIDHYFCDVLPLLKLACSDTFLIGLLMVANGGTLSVVSFLVLLVSYAVILLHLRTQSSEGRRKALSTCGSHIAVVTLFFGPCLFIYLRPSTILPVDKVVAVFYTVITPLLNPVIYSLRNAEMKKAVKRLWIRTVKLEEK", "length": 309 }, "evidence": [ { "id": "A0AAA9SY50", "url": "https://omabrowser.org/oma/group/A0AAA9SY50/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8VEZ3-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADIHNVTEFLFLGLSSNKEVEIVCFVIFLLLYMAIVLGNLLMVVTVVASRSLGSPMYFFLGYLSFVEICYSSTTAPKLILDLLAEKKSISVWGCMTQLFFMHFFGGAEIFLLTVMAYDRYVAICKPLHYTSIMNRNVCAVLVGTAWIGGFVHSFAQILLIFPLPFCGPNIIDHYFCDLLPLLKLACSDTFLIGLLIVANAGTLSVISFVVLLASYVVILFHLRTQSAEGRRKALSTCGSHVTVVILFFGPCVFIYLRPSDTLPVDKMIAVFYTVITPLLNPLIYSLRNAKVKKTMKSLWFRTMKVDEK", "length": 309 }, "evidence": [ { "id": "A0AAA9SY50", "url": "https://omabrowser.org/oma/group/A0AAA9SY50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SY50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY50" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 285, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 }, { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0G9-1", "uniprot_ac": "A0AAA9T0G9", "uniprot_id": "A0AAA9T0G9_BOVIN", "mass": { "chemical_mass": 24780.0, "monoisotopic_mass": 24780.0 }, "refseq": {}, "gene_names": [ { "name": "ARL15", "type": "recommended", "evidence": [ { "id": "A0AAA9T0G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-like protein 15", "type": "recommended", "evidence": [ { "id": "A0AAA9T0G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9", "locus": { "chromosome": "20", "start_pos": 25221875, "end_pos": 24750157, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019834", "url": "https://www.ensembl.org/id/ENSBTAG00000019834" } ] } } ], "crossref": [ { "id": "A0AAA9T0G9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0G9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019834", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019834", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04162", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04162", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G8JKY9", "url": "https://www.orthodb.org/?gene=G8JKY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46693", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46693", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46693:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46693:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RZU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NIK8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NIK8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G8JKY9", "url": "https://www.uniprot.org/uniprotkb/G8JKY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G8JKY9-1", "url": "https://www.uniprot.org/uniprotkb/G8JKY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDLRISEAFLYMDYLRMSECIQISFAVCRIGIYTCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 221, "header": "tr|A0AAA9T0G9-1|A0AAA9T0G9_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9RZU7-1", "sequence": { "sequence": "EKECFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 189, "header": "tr|A0AAA9RZU7-1|A0AAA9T0G9_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24765211, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098702.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098702.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076607.1" } ] } }, { "isoform_ac": "A0AAA9SKT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9SKT4-1", "sequence": { "sequence": "MERIHGFLSCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 195, "header": "tr|A0AAA9SKT4-1|A0AAA9T0G9_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24813922, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092015.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092015.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085900.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085900.1" } ] } }, { "isoform_ac": "A0AAA9SSI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9SSI8-1", "sequence": { "sequence": "MGPLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 190, "header": "tr|A0AAA9SSI8-1|A0AAA9T0G9_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24805816, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092114.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092114.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087086.1" } ] } }, { "isoform_ac": "A0AAA9SY30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9SY30-1", "sequence": { "sequence": "QSECFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 189, "header": "tr|A0AAA9SY30-1|A0AAA9SY30_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24830911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131773.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131773.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091378.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091378.1" } ] } }, { "isoform_ac": "A0AAA9T0G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9T0G9-1", "sequence": { "sequence": "MSDLRISEAFLYMDYLRMSECIQISFAVCRIGIYTCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 221, "header": "tr|A0AAA9T0G9-1|A0AAA9T0G9_BOVIN Isoform 1 of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24762626, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101589.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101589.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092270.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092270.1" } ] } }, { "isoform_ac": "A0AAA9TIU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9TIU7-1", "sequence": { "sequence": "GLRRNQRWNSSECFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 198, "header": "tr|A0AAA9TIU7-1|A0AAA9TIU7_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24750356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128582.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128582.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096161.1" } ] } }, { "isoform_ac": "A0AAA9TVB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9TVB6-1", "sequence": { "sequence": "MSDLRISEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 182, "header": "tr|A0AAA9TVB6-1|A0AAA9TVB6_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24762626, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126157.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126157.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102563.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102563.1" } ] } }, { "isoform_ac": "A0AAA9TXW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0AAA9TXW4-1", "sequence": { "sequence": "QCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVKKYFELEPLARGKRWILQPCSLDDMEALKDSFSQLINLLEDHEAVRM", "length": 187, "header": "tr|A0AAA9TXW4-1|A0AAA9TXW4_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25220871, "end_pos": 24762886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107818.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107818.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102045.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102045.1" } ] } }, { "isoform_ac": "A0ABI0NIK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#A0ABI0NIK8-1", "sequence": { "sequence": "MSDLRISEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEVCLTKVTTLGLTVCCTCAAMLESEKIPVIRDMLVILLLNMKF", "length": 196, "header": "tr|A0ABI0NIK8-1|A0ABI0NIK8_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=1 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25001430, "end_pos": 24762626, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143969.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143969.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104033.1" } ] } }, { "isoform_ac": "G8JKY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9/entry#G8JKY9-1", "sequence": { "sequence": "MSDLRISEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDSVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEENHLKIVCHKNFCCIPVSETDVLLVTLQGILGLS", "length": 188, "header": "tr|G8JKY9-1|G8JKY9_BOVIN Computationally mapped isoform of ADP-ribosylation factor-like protein 15 OS=Bos taurus OX=9913 GN=ARL15 PE=3 SV=3 CANONICAL=A0AAA9T0G9-1" }, "locus": { "chromosome": "20", "start_pos": 25009680, "end_pos": 24762626, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026428.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026428.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026428.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026428.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9TXW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXW4#function" }, { "id": "A0AAA9TXW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXW4" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 31, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 31, "end_pos": 31, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9RZU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU7#function" }, { "id": "A0AAA9RZU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU7" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" }, { "id": "A0AAA9SY30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY30#function" }, { "id": "A0AAA9SY30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY30" } ], "binding_site_uniprot": 33, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 33, "end_pos": 33, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SSI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI8#function" }, { "id": "A0AAA9SSI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI8" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 34, "amino_acid": "Tyr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 34, "end_pos": 34, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT4#function" }, { "id": "A0AAA9SKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT4" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 39, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 39, "end_pos": 39, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU7#function" }, { "id": "A0AAA9TIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU7" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 42, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 42, "end_pos": 42, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TVB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB6#function" }, { "id": "A0AAA9TVB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB6" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" }, { "id": "G8JKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G8JKY9#function" }, { "id": "G8JKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G8JKY9" }, { "id": "A0ABI0NIK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIK8#function" }, { "id": "A0ABI0NIK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIK8" } ], "binding_site_uniprot": 46, "amino_acid": "Pro", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 46, "end_pos": 46, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TXW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXW4#function" }, { "id": "A0AAA9TXW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXW4" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 48, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 48, "end_pos": 48, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9RZU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU7#function" }, { "id": "A0AAA9RZU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU7" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" }, { "id": "A0AAA9SY30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY30#function" }, { "id": "A0AAA9SY30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY30" } ], "binding_site_uniprot": 50, "amino_acid": "Pro", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 50, "end_pos": 50, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SSI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI8#function" }, { "id": "A0AAA9SSI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI8" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 51, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 51, "end_pos": 51, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT4#function" }, { "id": "A0AAA9SKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT4" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 56, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 56, "end_pos": 56, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU7#function" }, { "id": "A0AAA9TIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU7" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 59, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 59, "end_pos": 59, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TVB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB6#function" }, { "id": "A0AAA9TVB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVB6" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" }, { "id": "G8JKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G8JKY9#function" }, { "id": "G8JKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G8JKY9" }, { "id": "A0ABI0NIK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIK8#function" }, { "id": "A0ABI0NIK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIK8" } ], "binding_site_uniprot": 63, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 63, "end_pos": 63, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T0G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9#function" }, { "id": "A0AAA9T0G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 65, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 65, "end_pos": 65, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T0G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9#function" }, { "id": "A0AAA9T0G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G9" }, { "id": "PIRSR606689-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606689-2" } ], "binding_site_uniprot": 82, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 82, "end_pos": 82, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZZ8-1", "uniprot_ac": "A0AAA9SZZ8", "uniprot_id": "A0AAA9SZZ8_BOVIN", "mass": { "chemical_mass": 110055.0, "monoisotopic_mass": 110055.0 }, "refseq": { "ac": "XP_002688800", "name": "zinc finger SWIM domain-containing protein 4 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688800" }, "gene_names": [ { "name": "ZSWIM4", "type": "recommended", "evidence": [ { "id": "A0AAA9SZZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8" } ] }, { "name": "ZSWIM4", "type": "synonym", "evidence": [ { "id": "XP_002688800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688800" } ] } ], "protein_names": [ { "name": "Zinc finger SWIM-type containing 4", "type": "synonym", "evidence": [ { "id": "A0AAA9SZZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger SWIM domain-containing protein 4 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_002688800", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688800" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSWIM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8", "locus": { "chromosome": "7", "start_pos": 11842104, "end_pos": 11864855, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002527", "url": "https://www.ensembl.org/id/ENSBTAG00000002527" } ] } } ], "crossref": [ { "id": "A0AAA9SZZ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002527", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002527", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781514", "url": "https://www.ncbi.nlm.nih.gov/gene/781514", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781514", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781514", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ILMTQQF", "url": "https://omabrowser.org/oma/group/ILMTQQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLA3", "url": "https://www.orthodb.org/?gene=F1MLA3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22619", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22619", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22619:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22619:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688800", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688800", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLA3", "url": "https://www.uniprot.org/uniprotkb/F1MLA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLA3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPPAAKRSRGCPAGPEERNAGAGAVRGRGRPEALLDLSAKRVAENWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNVREPGGPGEPERLYHVSISFDRCKITSVTCGCDNRDLFYCAHVVALSLHRIRHAHQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNGGYYGASQQLRSMFCKVREMLRMRDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVILSPHCRPEERTSWLQLLSKWDKLDVCPLEEGNYSFDGPSLQPTAALIPELLQKGSTCITNMEGWVGHPLDPIGCLCRALLEACRLEEETLAIYPDSGPEKRKVAYQHVPVPGSPGESYLAMALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGQLLEGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLALRAMRLPVLETAFPAGEPPSNPLDSIMSNRFPRWFILGHLETRQCELASAMLTAAKGDPKWLHAVLGSIQQNIHSPALLFKLAQDACKTATPASAPPDTTLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLLRLQLDAARREELWACARTLALQCAMKDPQNCALPALTLCEKNQAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRAAKPLGADRAPLCQLLDAAVAAYITTSHSRLTHISPRHYSDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG", "length": 989, "header": "tr|A0AAA9SZZ8-1|A0AAA9SZZ8_BOVIN Isoform 1 of Zinc finger SWIM-type containing 4 OS=Bos taurus OX=9913 GN=ZSWIM4 PE=4 SV=1 CANONICAL=A0AAA9SZZ8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8/entry#A0AAA9RYC5-1", "sequence": { "sequence": "MDPPAAKRSRGCPAGPEERNAGAGAVRGRGRPEALLDLSAKRVAENWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNVREPGGPGEPERLYHVSISFDRCKITSVTCGCDNRDLFYCAHVVALSLHRIRHAHQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNGGYYGASQQLRSMFCKVREMLRMRDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVILSPHCRPEERTSWLQLLSKWDKLDVCPLEEGNYSFDGPSLQPTAALIPGPEEEVMAMAAGSRHTVFGRALQAGSLHWSDDHLQRILASDSYSPNLTGNGGSDKPTFDPQGRPLWLGEPFPTTCARVDTLRAHGYPRQALRLASAIVNTLRLQQRHQLQIYKQQKKELLQKGSTCITNMEGWVGHPLDPIGCLCRALLEACRLEEETLAIYPGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLALRAMRLPVLETAFPAGEPPSNPLDSIMSNRFPRWFILGHLETRQCELASAMLTAAKGDPKWLHAVLGSIQQNIHSPALLFKLAQDACKTATPASAPPDTTLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLLRLQLDAARREELWACARTLALQCAMKDPQNCALPALTLCEKNQAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRAAKPLGADRAPLCQLLDAAVAAYITTSHSRLTHISPRHYSDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG", "length": 1021, "header": "tr|A0AAA9RYC5-1|A0AAA9SZZ8_BOVIN Computationally mapped isoform of Zinc finger SWIM-type containing 4 OS=Bos taurus OX=9913 GN=ZSWIM4 PE=4 SV=1 CANONICAL=A0AAA9SZZ8-1" }, "locus": { "chromosome": "7", "start_pos": 11864656, "end_pos": 11843108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087739.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087739.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078566.1" } ] } }, { "isoform_ac": "A0AAA9SZZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8/entry#A0AAA9SZZ8-1", "sequence": { "sequence": "MDPPAAKRSRGCPAGPEERNAGAGAVRGRGRPEALLDLSAKRVAENWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNVREPGGPGEPERLYHVSISFDRCKITSVTCGCDNRDLFYCAHVVALSLHRIRHAHQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNGGYYGASQQLRSMFCKVREMLRMRDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVILSPHCRPEERTSWLQLLSKWDKLDVCPLEEGNYSFDGPSLQPTAALIPELLQKGSTCITNMEGWVGHPLDPIGCLCRALLEACRLEEETLAIYPDSGPEKRKVAYQHVPVPGSPGESYLAMALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGQLLEGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLALRAMRLPVLETAFPAGEPPSNPLDSIMSNRFPRWFILGHLETRQCELASAMLTAAKGDPKWLHAVLGSIQQNIHSPALLFKLAQDACKTATPASAPPDTTLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLLRLQLDAARREELWACARTLALQCAMKDPQNCALPALTLCEKNQAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRAAKPLGADRAPLCQLLDAAVAAYITTSHSRLTHISPRHYSDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG", "length": 989, "header": "tr|A0AAA9SZZ8-1|A0AAA9SZZ8_BOVIN Isoform 1 of Zinc finger SWIM-type containing 4 OS=Bos taurus OX=9913 GN=ZSWIM4 PE=4 SV=1 CANONICAL=A0AAA9SZZ8-1" }, "locus": { "chromosome": "7", "start_pos": 11864656, "end_pos": 11843108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105644.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105644.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090996.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090996.1" } ] } }, { "isoform_ac": "F1MLA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8/entry#F1MLA3-1", "sequence": { "sequence": "MDPPAAKRSRGCPAGPEERNAGAGAVRGRGRPEALLDLSAKRVAENWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNVREPGGPGEPERLYHVSISFDRCKITSVTCGCDNRDLFYCAHVVALSLHRIRHAHQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNGGYYGASQQLRSMFCKVREMLRMRDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVILSPHCRPEERTSWLQLLSKWDKLDVCPLEEGNYSFDGPSLQPTAALIPGPEEEVMAMAAGSRHTVFGRALQAGSLHWSDDHLQRILASDSYSPNLTGNGGSDKPTFDPQGRPLWLGEPFPTTCARVDTLRAHGYPRQALRLASAIVNTLRLQQRHQLQIYKQQKKELLQKGSTCITNMEGWVGHPLDPIGCLCRALLEACRLEEETLAIYPDSGPEKRKVAYQHVPVPGSPGESYLAMALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGQLLEGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLALRAMRLPVLETAFPAGEPPSNPLDSIMSNRFPRWFILGHLETRQCELASAMLTAAKGDPKWLHAVLGSIQQNIHSPALLFKLAQDACKTATPASAPPDTTLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLLRLQLDAARREELWACARTLALQCAMKDPQNCALPALTLCEKNQAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRAAKPLGADRAPLCQLLDAAVAAYITTSHSRLTHISPRHYSDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG", "length": 1106, "header": "tr|F1MLA3-1|A0AAA9SZZ8_BOVIN Computationally mapped isoform of Zinc finger SWIM-type containing 4 OS=Bos taurus OX=9913 GN=ZSWIM4 PE=4 SV=3 CANONICAL=A0AAA9SZZ8-1" }, "locus": { "chromosome": "7", "start_pos": 11864656, "end_pos": 11843108, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003278.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003278.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003278.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003278.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 243, "start_aa": "Thr", "end_pos": 243, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr243", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:781514", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781514", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SD76-1", "protein_name": "Zinc finger SWIM-type containing 4", "gene_name": "ZSWIM4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPPAAKRSRGCPAGPEERNAGVATVRGRGRPEALLDLSAKRVAESWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNIRELGGPGEPERLYHVSISFDRCKITSVSCGCDNRDLFYCAHVVALSLYRIRHARQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNDGYYGASQQLRSMFCKVREMLRMRDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVVLSPHCKPEERTSWLQLLGKWDKLDVCPLEEGNYSFDGPSLQPTSALSPGPEEEEEVVATGSRHTVFGRALQAGSLHWSDAHLQRILAGDSYSPSLTGNMGSDKPAFDPQGRPLWLGEPFPTACARVDTLRAHGYPRQALRLAGAIVNTLRLQRRHQLESYKQQKKELLQKGSTCITNMEGWVGHPLDPIGCLCRALLEASRLEEETLALYPDSGPEKRKVAYQHVPVPGSPGESYLAMALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGQLLEGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLSLRAMRLPVLETAFPAGETHGNPLDSIMSNRFPRWFILGHLETRQCELASTMLTAAKGDPKWLHAVLGSIQQNIHSPALLFKLAQDACKTATPASAPPDTTLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLLRLQLDASRREELWACARTLALQCAMKDPQNCALPALTLCEKNHAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPSLGPLGARRAAKPLGADRAPLCQLLDAAVAAYITTSHSRLTHISPRHYGDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG", "length": 1106 }, "evidence": [ { "id": "A0AAA9SZZ8", "url": "https://omabrowser.org/oma/group/A0AAA9SZZ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8C7B8-1", "protein_name": "Zinc finger SWIM domain-containing protein 4", "gene_name": "Zswim4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPPAAKRSRGCPAGDEPGTGARRSRPEPLLDLSAKRVAESWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYQPPEGEQDTRVPFTRGLHLLQSGAVDRVLQVGFHLSGNIREVGGPGEPEHLYHVSISFDRCKITSVSCGCDNRDLFYCAHVVALSLYRIRHARQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVHGAPDPTAGAGTEDANCWHLDEEQIQEQVKQLLSNGGHYGASQQLRSMFSKVREMLRARDSNGARMLILMTEQFLQDPRLALWRQQGAGMTDKCRQLWDELGALWVCVILSPHCKPDERSGWLQLLGTWDKLDVCPLEEGNYSLDIPSLQPALTSRTGSEDEEEVTAASPRRTVFSRALQAGELHWNDSHLQRILASDSCGPTLTGSMGSDKPTFDPQGHPIWLGEPFPTACARVDTLRAHGYPHKALRLACAIINTLRLQRRHQLESYKQQKKELLQKGATGVTSTEGWVGHPLDPIGCLCRALLEACRLEEEPHSLFPDSAPEKRKLAYQHVLVPGSPGESYLALALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGLLLEGGPFSGFGEVIFRESVPMHTCARYLFTALLPHDPDLAFRLALRAMRLPVLETTFPAGESHPNPLDSIMSNRFPRWFILGHLETRQCELASTMLTAAKGDTKWLHAVLGSVQQNIHSPALLFKLAQDACKTATPASAPPDTVLLGIALELGLQVMRMTLNTMTWRRREMVRWLVSCATEIGPPALMSIMKNWYSLFTPVEAVTIVAVTGTTHATLLRLQLDTAGREELWACARTLALQCAMKDPQNCALPALTLCEKNHAAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRATKPLGTDRAPLCQLLDAAVAAYITTSHSRLTHISPRHYGDFIEFLGKARETFLLAPDGHLQFAQFLENLKQTYKGKKKLMLLVRERFG", "length": 1101 }, "evidence": [ { "id": "A0AAA9SZZ8", "url": "https://omabrowser.org/oma/group/A0AAA9SZZ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H7M6-1", "protein_name": "Zinc finger SWIM domain-containing protein 4", "gene_name": "ZSWIM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPPAAKRSRGCPAGPEERDAGAGAARGRGRPEALLDLSAKRVAESWAFEQVEERFSRVPEPVQKRIVFWSFPRSEREICMYSSLGYPPPEGEHDARVPFTRGLHLLQSGAVDRVLQVGFHLSGNIREPGSPGEPERLYHVSISFDRCKITSVSCGCDNRDLFYCAHVVALSLYRIRHAHQVELRLPISETLSQMNRDQLQKFVQYLISAHHTEVLPTAQRLADEILLLGSEINLVNGAPDPTAGAGIEDANCWHLDEEQIQEQVKQLLSNGGYYGASQQLRSMFSKVREMLRMRDSNGARMLILMTEQFLQDTRLALWRQQGAGMTDKCRQLWDELGALWVCVVLSPHCKPEERAGWLQLLSRWDKLDVCPLEEGNYSFDGPSLQPTMAPAPELLQKGSTCITNTEGWVGHPLDPIGCLCRALLEACRLEEETLTLYPDSGPEKRKVAYQHVPVPGSPGESYLVLALEVALLGLGQQRALPEGLYAQDKVVRNEEQLLALLEEVELDERLVQVLRKQAGLLLEGGPFSGFGEVLFRESVPMHTCARYLFTALLPHDPDLAYRLALRAMRLPILETAFPAGEPHPSPLDSIMSNRFPRWFILGHLETRQCELASTMLTAAKGDPKWLHTVLGSIQQNIHSPALLFKLAQDACKTATPVSAPPDTTLLGIALELGLQVMRMTLNVMTWRRREMVRWLVSCATEIGPQALMNIMQNWYSLFTPVEAATIVAVTGTTHATLLRLQLDTSRREELWACARTLALQCAMKDPQNCALPALTLCEKNHSAFEAAYQIVLDAAAGGLGHAHLFTVARYMEHRGLPLRAYKLATLALAQLSIAFNQDSHPAVNDVLWACSLSHSLGRHELSAIVPLIIRSIHCAPMLSDILRRWTLSAPGLGPLGARRAAKPLGADRAPLCQLLDAAVTAYITTSHSRLTHISPRHYGDFIEFLGKARETFLLAPDGHLQFSQFLENLKQTYKGKKKLMLLVRERFG", "length": 989 }, "evidence": [ { "id": "A0AAA9SZZ8", "url": "https://omabrowser.org/oma/group/A0AAA9SZZ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ8" }, { "id": "PS50966", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50966" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SWIM-type", "eco_id": "ECO_0000259", "start_pos": 139, "end_pos": 176, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 243 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 377, "end_pos": 379 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0I3-1", "uniprot_ac": "A0AAA9T0I3", "uniprot_id": "A0AAA9T0I3_BOVIN", "mass": { "chemical_mass": 36986.0, "monoisotopic_mass": 36986.0 }, "refseq": {}, "gene_names": [ { "name": "RMDN1", "type": "recommended", "evidence": [ { "id": "A0AAA9T0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3" } ] } ], "protein_names": [ { "name": "Regulator of microtubule dynamics protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM82B", "type": "synonym", "evidence": [ { "id": "A0AAA9T0I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RMDN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3", "locus": {} } ], "crossref": [ { "id": "A0AAA9T0I3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015734", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015734", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513788", "url": "https://www.ncbi.nlm.nih.gov/gene/513788", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLW4", "url": "https://www.orthodb.org/?gene=A0A3Q1LLW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16056", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16056", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16056:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16056:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21033", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21033", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LLW4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1T4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1T4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGHCPPADVVRRKLPRGTGSGGETGSGRETGSGQARLPLERRNAFSSAPLLAAEEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKWYAICIGDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTVAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQIQTEAAQLLRGFSDKN", "length": 329, "header": "tr|A0AAA9T0I3-1|A0AAA9T0I3_BOVIN Isoform 1 of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=3 SV=1 CANONICAL=A0AAA9T0I3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3/entry#A0A3Q1LLW4-1", "sequence": { "sequence": "MALAVRFWCLFPVGRSAAWGLRLPAGAAGSRGQRVPWRLGASEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKKAIELNPKDATSIHLMGIWCYTVAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQIQTEAAQLLRGFSDKN", "length": 287, "header": "tr|A0A3Q1LLW4-1|A0A3Q1LLW4_BOVIN Computationally mapped isoform of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=3 SV=2 CANONICAL=A0AAA9T0I3-1" }, "locus": { "chromosome": "14", "start_pos": 76212449, "end_pos": 76178800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076049.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076049.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060822.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060822.2" } ] } }, { "isoform_ac": "A0AAA9T0I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3/entry#A0AAA9T0I3-1", "sequence": { "sequence": "MGHCPPADVVRRKLPRGTGSGGETGSGRETGSGQARLPLERRNAFSSAPLLAAEEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKWYAICIGDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTVAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQIQTEAAQLLRGFSDKN", "length": 329, "header": "tr|A0AAA9T0I3-1|A0AAA9T0I3_BOVIN Isoform 1 of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=3 SV=1 CANONICAL=A0AAA9T0I3-1" }, "locus": { "chromosome": "14", "start_pos": 76212449, "end_pos": 76178605, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091612.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091612.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089155.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089155.1" } ] } }, { "isoform_ac": "A0AAA9TFV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3/entry#A0AAA9TFV0-1", "sequence": { "sequence": "MALAVRFWCLFPVGRSAAWGLRLPAGAAGSRGQRVPWRLGASEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKWYAICIGDVGDYEGIKAKIANAYIIKEHFEKAIELNPKDATSIHLMGIWCYTVAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQKCCCCC", "length": 307, "header": "tr|A0AAA9TFV0-1|A0AAA9T0I3_BOVIN Computationally mapped isoform of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=3 SV=1 CANONICAL=A0AAA9T0I3-1" }, "locus": { "chromosome": "14", "start_pos": 76232082, "end_pos": 76178800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124252.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124252.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095057.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095057.1" } ] } }, { "isoform_ac": "A0AAF6Z1T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3/entry#A0AAF6Z1T4-1", "sequence": { "sequence": "MALAVRFWCLFPVGRSAAWGLRLPAGAAGSRGQRVPWRLGASEAMGNSGTFKRSLLFSALSYLGFETYQVISQAVLVHAAAKVFEIEEVLEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSGTSEEEKKFLVYEALEYAKRALEKNESSCAAHKWYAICIGDVGDYEGIKAKIANAYIIKEHFETSVSLISFAEMPWYQRRIAKVLFATPPGSTYEEALGYFHRAEQVDPNFYSKNLLLLGKTYLKLHNKKLAAFWLTKAKDYPAHTEEDKQIQTEAAQLLRGFSDKN", "length": 302, "header": "tr|A0AAF6Z1T4-1|A0AAF6Z1T4_BOVIN Computationally mapped isoform of Regulator of microtubule dynamics protein 1 OS=Bos taurus OX=9913 GN=RMDN1 PE=3 SV=1 CANONICAL=A0AAA9T0I3-1" }, "locus": { "chromosome": "14", "start_pos": 76212449, "end_pos": 76178800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020889.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020889.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020889.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020889.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXC4-1", "uniprot_ac": "A0AAA9SXC4", "uniprot_id": "A0AAA9SXC4_BOVIN", "mass": { "chemical_mass": 113280.0, "monoisotopic_mass": 113280.0 }, "refseq": {}, "gene_names": [ { "name": "DLG2", "type": "recommended", "evidence": [ { "id": "A0AAA9SXC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ] } ], "protein_names": [ { "name": "Discs large MAGUK scaffold protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SXC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DLG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4", "locus": { "chromosome": "29", "start_pos": 12252183, "end_pos": 9934475, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027868", "url": "https://www.ensembl.org/id/ENSBTAG00000027868" } ] } } ], "crossref": [ { "id": "A0AAA9SXC4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXC4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027868", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027868", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06723", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06723", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06724", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06724", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06795", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06795", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12032", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12032", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100851408", "url": "https://www.ncbi.nlm.nih.gov/gene/100851408", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LS38", "url": "https://www.orthodb.org/?gene=A0A3Q1LS38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09058", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LS38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1B4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1B4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBA8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5A4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5A4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5A4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCJ5", "url": "https://www.uniprot.org/uniprotkb/E1BCJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCJ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNQ1", "url": "https://www.uniprot.org/uniprotkb/F1MNQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNQ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MNQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVKKKDTDRALSLLEEYCKKLRKPEEQQLKNAVKKVMGIFKSSLFRALLDIQEFYEVTLLNSQKSCEQKIEEANQVAQKWEKTSFLASCHDNLQKSAELTVCSEPKENASCIEQNKDNQCFTNKKTSQNQGKCPAQNCSVEGPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 1009, "header": "tr|A0AAA9SXC4-1|A0AAA9SXC4_BOVIN Isoform 1 of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=1 CANONICAL=A0AAA9SXC4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0A3Q1LS38-1", "sequence": { "sequence": "MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 870, "header": "tr|A0A3Q1LS38-1|A0AAA9SXC4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=2 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 10631849, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087032.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087032.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059831.2" } ] } }, { "isoform_ac": "A0A3Q1N1B4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0A3Q1N1B4-1", "sequence": { "sequence": "MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLKHVSSNASDSESSYRGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 866, "header": "tr|A0A3Q1N1B4-1|A0AAA9SXC4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=2 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 10631849, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080082.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080082.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062784.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062784.2" } ] } }, { "isoform_ac": "A0AAA9SBA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0AAA9SBA8-1", "sequence": { "sequence": "MNAHLTKQHSCPRGSGGTDAGRSVPTLIRDAHCACGWQRSPQGLGYTSQTMPPSGAGGPASNRTKWTLWDSVRKSPRKTSTKGRGACGERCACPHGWISPAQASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 904, "header": "tr|A0AAA9SBA8-1|A0AAA9SXC4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=1 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 11312949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126965.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126965.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082667.1" } ] } }, { "isoform_ac": "A0AAA9SLX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0AAA9SLX5-1", "sequence": { "sequence": "MPVKKKDTDRALSLLEEYCKKLRKPEEQQLKNAVKKVMGIFKSSLFRALLDIQEFYEVTLLNSQKSCEQKIEEANQVAQKWEKTSFLASCHDNLQKSAELTVCSEPKENASCIEQNKDNQCFTNKKTSKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 966, "header": "tr|A0AAA9SLX5-1|A0AAA9SXC4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=1 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 9934475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099962.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099962.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087351.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087351.1" } ] } }, { "isoform_ac": "A0AAA9SUG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0AAA9SUG7-1", "sequence": { "sequence": "MDCLCIVTTKQNQGKCPAQNCSVEGPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 821, "header": "tr|A0AAA9SUG7-1|A0AAA9SXC4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=1 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 10412661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102934.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102934.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088985.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088985.1" } ] } }, { "isoform_ac": "A0AAA9SXC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0AAA9SXC4-1", "sequence": { "sequence": "MPVKKKDTDRALSLLEEYCKKLRKPEEQQLKNAVKKVMGIFKSSLFRALLDIQEFYEVTLLNSQKSCEQKIEEANQVAQKWEKTSFLASCHDNLQKSAELTVCSEPKENASCIEQNKDNQCFTNKKTSQNQGKCPAQNCSVEGPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 1009, "header": "tr|A0AAA9SXC4-1|A0AAA9SXC4_BOVIN Isoform 1 of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=1 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 9934475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123569.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123569.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088726.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088726.1" } ] } }, { "isoform_ac": "A0AAA9T5A4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0AAA9T5A4-1", "sequence": { "sequence": "MFASIWYAKKLGRRFVHNARKAKSEKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 810, "header": "tr|A0AAA9T5A4-1|A0AAA9T5A4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=4 SV=1 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 11167913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101205.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101205.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091725.1" } ] } }, { "isoform_ac": "A0AAA9TCW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#A0AAA9TCW9-1", "sequence": { "sequence": "MSLVVQDPDCFTPMICHCKVACTNNTLSLMFGCKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 890, "header": "tr|A0AAA9TCW9-1|A0AAA9TCW9_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=4 SV=1 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 10842022, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102019.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102019.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095919.1" } ] } }, { "isoform_ac": "E1BCJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#E1BCJ5-1", "sequence": { "sequence": "MQRPSASRAENYQLLWDTIASLKQCEQAMQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYPHYHLGLLPDSEMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTGMFFAFVL", "length": 810, "header": "tr|E1BCJ5-1|E1BCJ5_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=4 SV=4 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12248972, "end_pos": 11352594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040186.6", "url": "https://www.ensembl.org/id/ENSBTAT00000040186.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039964.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039964.6" } ] } }, { "isoform_ac": "F1MNQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4/entry#F1MNQ1-1", "sequence": { "sequence": "MNAHLTKQHSCPRGSGGTDAGRSVPTLIRDAHCACGWQRSPQGLGYTSQTMPPSGAGGPASNRTKWTLWDSVRKSPRKTSTKGRGACGERCACPHGWISPAQASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDCILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL", "length": 852, "header": "tr|F1MNQ1-1|A0AAA9SXC4_BOVIN Computationally mapped isoform of Discs large MAGUK scaffold protein 2 OS=Bos taurus OX=9913 GN=DLG2 PE=3 SV=4 CANONICAL=A0AAA9SXC4-1" }, "locus": { "chromosome": "29", "start_pos": 12251179, "end_pos": 11312949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027163.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027163.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027163.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027163.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 660, "end_pos": 662, "annotation": "n_glycosylation_sequon" }, { "start_pos": 711, "end_pos": 713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 817, "end_pos": 819, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" }, { "id": "PS50052", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50052" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Guanylate kinase-like", "eco_id": "ECO_0000259", "start_pos": 819, "end_pos": 994, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SXC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" }, { "id": "PS51022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "L27", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 64, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SXC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 324, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SXC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC4" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 675, "end_pos": 745, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 138, "end_pos": 140 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 227, "end_pos": 229 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 660, "end_pos": 662 }, { "start_pos": 711, "end_pos": 713 }, { "start_pos": 817, "end_pos": 819 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SX79-1", "uniprot_ac": "A0AAA9SX79", "uniprot_id": "A0AAA9SX79_BOVIN", "mass": { "chemical_mass": 113223.0, "monoisotopic_mass": 113223.0 }, "refseq": { "ac": "XP_005211596", "name": "rho GTPase-activating protein 11A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211596" }, "gene_names": [ { "name": "ARHGAP11A", "type": "recommended", "evidence": [ { "id": "A0AAA9SX79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79" } ] }, { "name": "ARHGAP11A", "type": "synonym", "evidence": [ { "id": "XP_005211596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211596" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 11A", "type": "recommended", "evidence": [ { "id": "A0AAA9SX79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79/entry#names_and_taxonomy" } ] }, { "name": "Rho-type GTPase-activating protein 11A", "type": "synonym", "evidence": [ { "id": "A0AAA9SX79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79/entry#names_and_taxonomy" } ] }, { "name": "rho GTPase-activating protein 11A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005211596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211596" } ] } ], "function": [ { "annotation": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79#function" }, { "database": "UniProtKB", "id": "ARBA00055252", "url": "https://www.uniprot.org/uniprotkb/ARBA00055252#function" }, { "database": "UniProtKB", "id": "E1BIM3", "url": "https://www.uniprot.org/uniprotkb/E1BIM3#function" }, { "database": "UniProtKB", "id": "A0A3Q1LSN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSN1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP11A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79", "locus": {} } ], "crossref": [ { "id": "A0AAA9SX79", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SX79", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020100", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04394", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04394", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617811", "url": "https://www.ncbi.nlm.nih.gov/gene/617811", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RQPIRHK", "url": "https://omabrowser.org/oma/group/RQPIRHK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSN1", "url": "https://www.orthodb.org/?gene=A0A3Q1LSN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIM3", "url": "https://www.orthodb.org/?gene=E1BIM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15670", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15670", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15670:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15670:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005211596", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSN1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIM3", "url": "https://www.uniprot.org/uniprotkb/E1BIM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGMWDQRLVRLAVVQQLRAAYGIKVKGGRAQCDRRRQETATTEIVGKIFGVPLNALPQSIVPEYGHIPSFLVDACTSLEEHVHTEGLFRKSGSVIRLKALKNKLDHGERCLSSAPPCDTAGLLKQFFRELPEPILPADLHEALFKAQQLKTEEKNKATLLLSCLMADHTIDILRYFFNFLRKVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFIDYASDIGHVPDFILEKIPAMLGIDGLCATPSLEGFEEGDYETPGDYKRKRRQSVGDFVSGALNKFKSNRTPSITPQQERIAQLSVSPTILTPNAKRKLPVDSHGLSSKKRKSIKHNFNFELLPSNLFSSSSTPISVHCDTSPEGSSQSSFSPVAISGNHLISTNVLRRSKRLASKKVCRVESGKAGCFSPKISRKEKVRRSLRLKFNLGKNSKDGNECSGVNRSENVGRRLANQQSLKNRIDSVKTGLLFSPDTDERLTQKGSKKISKSEENLLTPEQLSGTNYRISWIGPSNSDFQEVDGNEASPIDGTLEVENSSLEPDMMVEKSPVSSSGLTPPNVHSQHSNNTTGSSLSGDENNLTTETVVKIQKAFSESGSNLHALINHKQSSLTNVEKVKFNETSSTKGSPEKNLLKTNLTVIESNGHHTSNNEDSFSERDFSLHQPQKSDREATVKCYSTQLKIQLENNIHFNIPTDYLSKQELPSDEHVRKQESPRDTLNTKLKENENLIEENLLKHTASREVVASTSSLGQSTCSSTNLSKPSPGGIIKQQSPVETRDETVSECLQMTKHGRVSDHIQWFNNLSLNEPNRTKVKSPLKFQRTPVRQSVRRISSLLEYGGQPPRRKLASLGDTASPLVKSVSCESALPSCVESMTKDSSHPCTRSGPKEQKSSSCKQSNIDMISKSSMEVTSTSFLQMKRHPNSVNASLGSTRVCKQEVISNSQIKVPLDDLTNHDIVKSIVSNDKVFPPGVNSRVLRKPSEKERIWYKGSPKNPIGKLQLLPTSKPVDL", "length": 1023, "header": "tr|A0AAA9SX79-1|A0AAA9SX79_BOVIN Isoform 1 of Rho GTPase-activating protein 11A OS=Bos taurus OX=9913 GN=ARHGAP11A PE=4 SV=1 CANONICAL=A0AAA9SX79-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79/entry#A0A3Q1LSN1-1", "sequence": { "sequence": "MSGMWDQRLVRLAVVQQLRAAYGIKVKGGRAQCDRRRQETATTEIVGKIFGVPLNALPQSIVPEYGHIPSFLVDACTSLEEHVHTEGLFRKSGSVIRLKALKNKLDHGERCLSSAPPCDTAGLLKQFFRELPEPILPADLHEALFKAQQLKTEEKNKATLLLSCLMADHTIDILRYFFNFLRKVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFIDYASDIGHVPDFILEKIPAMLGIDGLCATPSLEGFEEGDYETPGDYKRKRRQSVGAQLSVSPTILTPNAKRKLPVDSHGLSSKKRKSIKHNFNFELLPSNLFSSSSTPISVHCDTSPEGSSQSSFSPVAISGNHLISTNVLRRSKRLASKKVCRVESGKAGCFSPKISRKEKVRRSLRLKFNLGKNSKDGNECSGVNRSENVGRRLANQQSLKNRIDSVKTGLLFSPDTDERLTQKGSKKISKSEENLLTPEQLSGTNYRISWIGPSNSDFQEVDGNEASPIDGTLEVENSSLEPDMMVEKSPVSSSGLTPPNVHSQHSNNTTGSSLSGDENNLTTETVVKIQKAFSESGSNLHALINHKQSSLTNVEKVKFNETSSTKGSPEKNLLKTNLTVIESNGHHTSNNEDSFSERDFSLHQPQKSDREATVKCYSTQLKIQLENNIHFNIPTDYLSKQELPSDEHVRKQESPRDTLNTKLKENENLIEENLLKHTASREVVASTSSLGQSTCSSTNLSKPSPGGIIKQQSPVETRDETVSECLQMTKHGRVSDHIQWFNNLSLNEPNRTKVKSPLKFQRTPVRQSVRRISSLLEYGGQPPRRKLASLGDTASPLVKSVSCESALPSCVESMTKDSSHPCTRSGPKEQKSSSCKQSNIDMISKSSMEVTSTSFLQMKRHPNSVNASLGSTRVCKQEVISNSQIKVPLDDLTNHDIVKSIVSNDKVFPPGVNSRVLRKPSEKERIWYKGSPKNPIGKLQLLPTSKPVDL", "length": 998, "header": "tr|A0A3Q1LSN1-1|A0AAA9SX79_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 11A OS=Bos taurus OX=9913 GN=ARHGAP11A PE=4 SV=1 CANONICAL=A0AAA9SX79-1" }, "locus": { "chromosome": "10", "start_pos": 30086521, "end_pos": 30065661, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072404.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072404.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063393.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063393.1" } ] } }, { "isoform_ac": "A0AAA9SX79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79/entry#A0AAA9SX79-1", "sequence": { "sequence": "MSGMWDQRLVRLAVVQQLRAAYGIKVKGGRAQCDRRRQETATTEIVGKIFGVPLNALPQSIVPEYGHIPSFLVDACTSLEEHVHTEGLFRKSGSVIRLKALKNKLDHGERCLSSAPPCDTAGLLKQFFRELPEPILPADLHEALFKAQQLKTEEKNKATLLLSCLMADHTIDILRYFFNFLRKVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFIDYASDIGHVPDFILEKIPAMLGIDGLCATPSLEGFEEGDYETPGDYKRKRRQSVGDFVSGALNKFKSNRTPSITPQQERIAQLSVSPTILTPNAKRKLPVDSHGLSSKKRKSIKHNFNFELLPSNLFSSSSTPISVHCDTSPEGSSQSSFSPVAISGNHLISTNVLRRSKRLASKKVCRVESGKAGCFSPKISRKEKVRRSLRLKFNLGKNSKDGNECSGVNRSENVGRRLANQQSLKNRIDSVKTGLLFSPDTDERLTQKGSKKISKSEENLLTPEQLSGTNYRISWIGPSNSDFQEVDGNEASPIDGTLEVENSSLEPDMMVEKSPVSSSGLTPPNVHSQHSNNTTGSSLSGDENNLTTETVVKIQKAFSESGSNLHALINHKQSSLTNVEKVKFNETSSTKGSPEKNLLKTNLTVIESNGHHTSNNEDSFSERDFSLHQPQKSDREATVKCYSTQLKIQLENNIHFNIPTDYLSKQELPSDEHVRKQESPRDTLNTKLKENENLIEENLLKHTASREVVASTSSLGQSTCSSTNLSKPSPGGIIKQQSPVETRDETVSECLQMTKHGRVSDHIQWFNNLSLNEPNRTKVKSPLKFQRTPVRQSVRRISSLLEYGGQPPRRKLASLGDTASPLVKSVSCESALPSCVESMTKDSSHPCTRSGPKEQKSSSCKQSNIDMISKSSMEVTSTSFLQMKRHPNSVNASLGSTRVCKQEVISNSQIKVPLDDLTNHDIVKSIVSNDKVFPPGVNSRVLRKPSEKERIWYKGSPKNPIGKLQLLPTSKPVDL", "length": 1023, "header": "tr|A0AAA9SX79-1|A0AAA9SX79_BOVIN Isoform 1 of Rho GTPase-activating protein 11A OS=Bos taurus OX=9913 GN=ARHGAP11A PE=4 SV=1 CANONICAL=A0AAA9SX79-1" }, "locus": { "chromosome": "10", "start_pos": 30086521, "end_pos": 30065661, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116189.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116189.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087899.1" } ] } }, { "isoform_ac": "E1BIM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79/entry#E1BIM3-1", "sequence": { "sequence": "MSGMWDQRLVRLAVVQQLRAAYGIKVKGGRAQCDRRRQETATTEIVGKIFGVPLNALPQSIVPEYGHIPSFLVDACTSLEEHVHTEGLFRKSGSVIRLKALKNKLDHGERCLSSAPPCDTAGLLKQFFRELPEPILPADLHEALFKAQQLKTEEKNKATLLLSCLMADHTIDILRYFFNFLRKVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFIDYASDIEGFEEGDYETPGDYKRKRRQSVGDFVSGALNKFKSNRTPSITPQQERIAQLSVSPTILTPNAKRKLPVDSHGLSSKKRKSIKHNFNFELLPSNLFSSSSTPISVHCDTSPEGSSQSSFSPVAISGNHLISTNVLRRSKRLASKKVCRVESGKAGCFSPKISRKEKVRRSLRLKFNLGKNSKDGNECSGVNRSENVGRRLANQQSLKNRIDSVKTGLLFSPDTDERLTQKGSKKISKSEENLLTPEQLSGTNYRISWIGPSNSDFQEVDGNEASPIDGTLEVENSSLEPDMMVEKSPVSSSGLTPPNVHSQHSNNTTGSSLSGDENNLTTETVVKIQKAFSESGSNLHALINHKQSSLTNVEKVKFNETSSTKGSPEKNLLKTNLTVIESNGHHTSNNEDSFSERDFSLHQPQKSDREATVKCYSTQLKIQLENNIHFNIPTDYLSKQELPSDEHVRKQESPRDTLNTKLKENENLIEENLLKHTASREVVASTSSLGQSTCSSTNLSKPSPGGIIKQQSPVETRDETVSECLQMTKHGRVSDHIQWFNNLSLNEPNRTKVKSPLKFQRTPVRQSVRRISSLLEYGGQPPRRKLASLGDTASPLVKSVSCESALPSCVESMTKDSSHPCTRSGPKEQKSSSCKQSNIDMISKSSMEVTSTSFLQMKRHPNSVNASLGSTRVCKQEVISNSQIKVPLDDLTNHDIVKSIVSNDKVFPPGVNSRVLRKPSEKERIWYKGSPKNPIGKLQLLPTSKPVDL", "length": 997, "header": "tr|E1BIM3-1|A0AAA9SX79_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 11A OS=Bos taurus OX=9913 GN=ARHGAP11A PE=4 SV=3 CANONICAL=A0AAA9SX79-1" }, "locus": { "chromosome": "10", "start_pos": 30086521, "end_pos": 30065661, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035838.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035838.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035705.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035705.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 264, "start_aa": "Thr", "end_pos": 264, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr264", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4ILK3-1", "protein_name": "Rho GTPase-activating protein 11A isoform 1", "gene_name": "arhgap11a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRVLERNVVRLAVVQHLRSVYGIRIKNWNKNRSKQTSANTVRVFGVALEGLPHSHVLDYGDLPCFLVDICTTLLDHLDTEGLFRKSGSVVRVKSLRAKLDQGEDCLSAALPLDIAGLLKQFFRELPEPVLTVDLHSAFLKAQELPTAEERTSATVLLSCVLPDTNLNTLRYFFSFLKTVSQRCAENKMDSSNLAVIFAPNLFHCGDGGEKMSSSTEKRLKHQAAAVQCLIENAQRIGVVPQFLMEKVPAMLGCDAAVFSPSAVSPEDSNAHFDLKKSNRRSLGDVVNGALNRLKASRTPTNTPHSDGAVFSMATPVIMTPNSKRKLPLESSQTHGFSNKKRRSIKKNLGLELFPSVLFGGTSTPGSTHSAAGVLDSSHSGLLSSVGRNSRLSSSSARRKSRRLRDRSVSRVESGKAGCFSPRTAKKEPVRKSLRLRFSLGKSSRDSNLITHSQPVPKGSEVIGWRLATQESSTGFHFTKELSLPVLSKSPSKGSKFFSKSEDNLSTPQCDFTDHRSSWTGETPETGLTFPTDSFSETPLIIVSKPPTISSVPETTPEECSHTGHTLLKIRQAFGESGSDLHSIITQKDQQDDSSNVHLPSETAHKSISESGQSNDDVTFGQIEIVPLSPLHIDSALFDSEPTRFVETSLNGSLCFKNEYLKESAVRSVNCSQIIDALDIQSPVAFRLDTSTRVQSTPYATRSQVNANTSLQDELRASSLVEKKIESSQEQQNNAESKKSKVADQIKLFNMMTLHSPKVQLLRSPLKFQRTPVRQSVTRINSLAGKRKESRMGWCAASQVKAVSLESGLYSSVKPKPPVPLKKTAVKPAALEDITNKAPKAMLSNCKNAADEHPKCVLLKVSENDTSHYRGSPRHPLVEGRLLSAMKPIDL", "length": 890 }, "evidence": [ { "id": "A0AAA9SX79", "url": "https://omabrowser.org/oma/group/A0AAA9SX79/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A4X1UL79-1", "protein_name": "Rho GTPase-activating protein 11A", "gene_name": "ARHGAP11A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWDQKLVRLAVVQQLRAVYGIKVKGGRGQCDRRRQEAASTEKVGKIFGVPFNTLPQSLVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKLDHGERCLSSAPPCDIAGLLKQFFRELPEPILPGDLHEALFKAQQLRTEEKNTATLLLSCLLADHTIDLLRYFFNFLRKVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTLIDYASDIGHVPDIILEKIPGMLGIDGLCATPSLEGFEEGDYETPGDYKRKRRQSVGDFVSGALNKLKSSRTPSITPQQERTAQLSESPILTPNAKRKLPVDSHGFSSKKRRSIKHNFNFELLPSNLFSSSSTPVSVHFDTSPEGSSQGSLSPVAISGNHLISTGMLRRSKRIASKKVCRVESGKAGCFSPKISRKEKVRRSLRLKFSLGKSSKDGNACSGVDRSENVGRRLASQQSLKNRIESVKTGLLFSPDIDERLTKKGSKKISKSEENLLTPERPGGKSYRMSWTGPSGSSFQEIDGNETSPKDGTLEVENSSLEPDIMLEKSPVSAYEPTPSNVHNKHNNSITGSSLSGDENNLTTETVMKIQKAFSESGSNLHALINHGQSSLTNVEKVKFNETSSIEYSPEKNLFETNNLTVIESNEHHTYKDENSFSEGDLSLHQMQKLDSEITIKCYSTQMKIELESSIHSHIPKDDVSKQELPSDEQIKQESPGDTLNTKLKENENVIELLKSAASREDVASTSSSGQLTCNNANVSKPRPVRIAKQQSLVETCAKTVSERLQMTEHGKVSDHIQWFNKLSLNEPNQTKVKSPLKFQRTPVRQSVRRINSLLEYGGQPPRHKLASLGDTASPLVKSVSCDSALPSHIESTSKDSSIPRTKSGPKEQKSTSCKQTNTDMISKSSMELTCTSFSQMKRHPHSVNASVRSTRVCKQEVISNGQIKVPLDDLTNHDISKSVVNNDMGFSIGINNNKILRKPSEKERVWYKGSPKNPIGKAQLLPSSKPVDL", "length": 1018 }, "evidence": [ { "id": "A0AAA9SX79", "url": "https://omabrowser.org/oma/group/A0AAA9SX79/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3Z951-1", "protein_name": "Rho GTPase-activating protein 11A", "gene_name": "Arhgap11a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWDQRLVRLALLQQLRAVYGIKVKGGRGQCDRRRQETAATEIRGKIFGVPFNSLPHSVVPEYGHIPSFLVDACTSLKEHIHTEGLFRKSGSVIRLKALKSKLDHGEACLSSALPCDVAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLSCLMADPTVDVLRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTLIDYASDIGRVPDFILEKIPAMLGIDGLCTTPSLEGFEGDYETPGECKRKRRQSVGDFVNGALNKLKSSRTPSITPQQDRTAQAPVSPLILTPSVKRKLPGETSHTLSSKKRKSIKNNLNFELLPSHLFSSNSTPVSVHFDTSPEGSSQSSLSPIAMSGNHLTSTDLRRSKRIASKKVYRVESGKAGCFSPKVTRKEKVRRSLRLKFSLRKNRDSNGCSVINRHENVGRRLANQQNLKNRIESVKTGLLFSPDIDERLLKKGSEKISKSEEHLLTPDQLDGTGYRMSWTEPSNSSFQDMSANGTSPIMQNLEVKSFSLESNITVEKSPVVSCELRPSTFHSQPNSSVLGRSLSGDEGNLAFETLQKIQKAFSESGSDLHTAVNHEQSSVTNVGEEGESRDVSESKGHDGSYTGQDENYASERNLSPSQSPELAREASEECHSTQMKVGCESLHSETPRADLLQQAFPSEEPTKETQSPGSQLDTTPSQGDENVVEENSGACEAPEENDAQSLKQSTCSVTVISKPRAQRLARQRSLVEKCDSAVPGGPQMTEHGKVSDHIQWFNKLSLNEPNRGKVKSPLKFQRTPVRQSVRRINSLLEYGRQPVRQKLAVFGDAASPLVKSVSCDSALPSCVQSTSKGPCVPHTKPGLEAQKCTSCDKSSVELTSKSFTKMKRHPDPLNASLATTRLCKQENKSDVQIKFPLDDLTNHDRLKFVVNNNVDFPPGIKNRVLKKPLEKERVWYKGSPKNPIGKTQLLPTSKPVDL", "length": 994 }, "evidence": [ { "id": "A0AAA9SX79", "url": "https://omabrowser.org/oma/group/A0AAA9SX79/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P4F7-1", "protein_name": "Rho GTPase-activating protein 11A", "gene_name": "ARHGAP11A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWDQRLVRLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEDHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKATLLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFILEKIPAMLGIDGLCATPSLEGFEEGEYETPGEYKRKRRQSVGDFVSGALNKFKPNRTPSITPQEERIAQLSESPVILTPNAKRTLPVDSSHGFSSKKRKSIKHNFNFELLPSNLFNSSSTPVSVHIDTSSEGSSQSSLSPVLIGGNHLITAGVPRRSKRIAGKKVCRVESGKAGCFSPKISHKEKVRRSLRLKFNLGKNGREVNGCSGVNRYESVGWRLANQQSLKNRIESVKTGLLFSPDVDEKLPKKGSEKISKSEETLLTPERLVGTNYRMSWTGPNNSSFQEVDANEASSMVENLEVENSLEPDIMVEKSPATSCELTPSNLNNKHNSNITSSPLSGDENNMTKETLVKVQKAFSESGSNLHALMNQRQSSVTNVGKVKLTEPSYLEDSPEENLFETNDLTIVESKEKYEHHTGKGEKCFSERDFSPLQTQTFNRETTIKCYSTQMKMEHEKDIHSNMPKDYLSKQEFSSDEEIKKQQSPKDKLNNKLKENENMMEGNLPKCAAHSKDEARSSFSQQSTCVVTNLSKPRPMRIAKQQSLETCEKTVSESSQMTEHRKVSDHIQWFNKLSLNEPNRIKVKSPLKFQRTPVRQSVRRINSLLEYSRQPTGHKLASLGDTASPLVKSVSCDGALSSCIESASKDSSVSCIKSGPKEQKSMSCEESNIGAISKSSMELPSKSFLKMRKHPDSVNASLRSTTVYKQKILSDGQVKVPLDDLTNHDIVKPVVNNNMGISSGINNRVLRRPSERGRAWYKGSPKHPIGKTQLLPTSKPVDL", "length": 1023 }, "evidence": [ { "id": "A0AAA9SX79", "url": "https://omabrowser.org/oma/group/A0AAA9SX79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80Y19-1", "protein_name": "Rho GTPase-activating protein 11A", "gene_name": "Arhgap11a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWDQRLVRLALLQQLRAVYGIKVKGGRGQCDRRRHETAATEIKGKVFGVPFNSLPHSVVPEFGHIPSFLVDACASLKEHIHTEGLFRKSGSVVRLKALKSKLDQGEACLSSALPCDVAGLLKQFFRELPEPVLPADLHEALFKAQQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAAVVQTFIDCASDIGRVPDFILEKIPAMLGIDGLCTTPSLEGFEGDFETPGECKRKRRQSVGDFVNGALNKLKSSRTPSITPQQDRTAQASASPLILTPSVKRKLPGESSHAFSSKKRKSIKHNLNFELLPSHFFSSNSTPVSVHLDTSPDGSSQTSLSPIAMSGNHLVSTELRRSKRIASKKVYRVESGKAGCFSPKVSRKEKTRRSLRLKFSLGKNRDSDGCSVINRYENVGRRLANQQNLKSRIDSVKTGLLFSPDIDERLLKKGSEKISKSEEHLLTPDQLDGTGYRMSWTEPSNSSFQDMSANGTSPIMQNLEVKSFSLEPDITVEKSPVVSCELRPSTFHSQPDSSVLSLSGDEGNLASETLQKIQKAFSESGSDLHMVINHEQSSVTNTGEEVEFRDVTVTESKGHDGSCAGEEENCPSERNFSPDQSPEFAREADEECYSTQMKVECEGLHSETPKADPLILQAFPGEEPAEEPQSPRNQLSTPSRGNENGGESAGASGAPGEDESTCSVAVLSKPRPQRLSRQQSLVEKCDSVAPGALQVTEHGKVSDHIQWFNKLSLNEPNRGKVKSPLKFQRTPVRQSVRRINSLLEYGRQPVRQKLAIFGDAASPLVKSVSCDSALPSCVQNTSKGPTAPLITSGLEAQKSTSCNKSSVELTSKSFTKMKRHPDPLSASLGTPRLCKQENKSNGHIKFPLDDLTNHERLKFVVNNNVAFSPGMKNRVVRKPSEKERVWYKGSPKNPIGKTQLLPTSKPVDL", "length": 987 }, "evidence": [ { "id": "A0AAA9SX79", "url": "https://omabrowser.org/oma/group/A0AAA9SX79/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" }, { "start_pos": 580, "end_pos": 582, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 772, "end_pos": 774, "annotation": "n_glycosylation_sequon" }, { "start_pos": 816, "end_pos": 818, "annotation": "n_glycosylation_sequon" }, { "start_pos": 823, "end_pos": 825, "annotation": "n_glycosylation_sequon" }, { "start_pos": 939, "end_pos": 941, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SX79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX79" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 242, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 264 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 457, "end_pos": 459 }, { "start_pos": 550, "end_pos": 552 }, { "start_pos": 580, "end_pos": 582 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 593, "end_pos": 595 }, { "start_pos": 633, "end_pos": 635 }, { "start_pos": 650, "end_pos": 652 }, { "start_pos": 772, "end_pos": 774 }, { "start_pos": 816, "end_pos": 818 }, { "start_pos": 823, "end_pos": 825 }, { "start_pos": 939, "end_pos": 941 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SY47-1", "uniprot_ac": "A0AAA9SY47", "uniprot_id": "A0AAA9SY47_BOVIN", "mass": { "chemical_mass": 56607.0, "monoisotopic_mass": 56607.0 }, "refseq": { "ac": "XP_002691097", "name": "regulator of G-protein signaling 6 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691097" }, "gene_names": [ { "name": "RGS6", "type": "recommended", "evidence": [ { "id": "A0AAA9SY47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ] }, { "name": "RGS6", "type": "synonym", "evidence": [ { "id": "XP_002691097", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691097" } ] } ], "protein_names": [ { "name": "Regulator of G protein signaling 6", "type": "synonym", "evidence": [ { "id": "A0AAA9SY47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#names_and_taxonomy" } ] }, { "name": "regulator of G-protein signaling 6 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_002691097", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691097" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47", "locus": { "chromosome": "10", "start_pos": 84063446, "end_pos": 83455563, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014189", "url": "https://www.ensembl.org/id/ENSBTAG00000014189" } ] } } ], "crossref": [ { "id": "A0AAA9SY47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SY47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014189", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014189", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00068", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00068", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04450", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04450", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08737", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08737", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517545", "url": "https://www.ncbi.nlm.nih.gov/gene/517545", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517545", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517545", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LTJ9", "url": "https://www.orthodb.org/?gene=A0A3Q1LTJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFC7", "url": "https://www.orthodb.org/?gene=A0A3Q1MFC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLW7", "url": "https://www.orthodb.org/?gene=A0A3Q1MLW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTV8", "url": "https://www.orthodb.org/?gene=A0A3Q1MTV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MM21", "url": "https://www.orthodb.org/?gene=F1MM21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45746", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45746", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45746:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45746:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00631", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00631", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18148", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6814122", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002691097", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691097", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTJ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFC7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFC7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLW7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLW7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTV8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTV8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T559", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T559", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T559-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T559-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM21", "url": "https://www.uniprot.org/uniprotkb/F1MM21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM21-1", "url": "https://www.uniprot.org/uniprotkb/F1MM21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS", "length": 490, "header": "tr|A0AAA9SY47-1|A0AAA9SY47_BOVIN Isoform 1 of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=1 CANONICAL=A0AAA9SY47-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0A3Q1LTJ9-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGPVCKRQKAQQLPLQTGARPSPASPSPWPNICSPVQGGFEKEGPPLPHPWGCSVDAPSAAAQGEGHLAGP", "length": 544, "header": "tr|A0A3Q1LTJ9-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=2 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84040401, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077967.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077967.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060401.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060401.2" } ] } }, { "isoform_ac": "A0A3Q1MFC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0A3Q1MFC7-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQFFRHSVYQIFVNFQIFKLDLEEAEKNQRVNCQHLLDHRKSKRVPEKHLLLLY", "length": 478, "header": "tr|A0A3Q1MFC7-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=2 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84025830, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075674.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075674.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069825.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069825.2" } ] } }, { "isoform_ac": "A0A3Q1MLW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0A3Q1MLW7-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVDCVENYPARCILP", "length": 487, "header": "tr|A0A3Q1MLW7-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=2 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84050904, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080585.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080585.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070347.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070347.2" } ] } }, { "isoform_ac": "A0A3Q1MTV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0A3Q1MTV8-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKTLWLEVPSVSN", "length": 467, "header": "tr|A0A3Q1MTV8-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=2 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84043623, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074732.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074732.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058183.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058183.2" } ] } }, { "isoform_ac": "A0AAA9SD07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0AAA9SD07-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS", "length": 453, "header": "tr|A0AAA9SD07-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=1 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84062442, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125473.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125473.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080198.1" } ] } }, { "isoform_ac": "A0AAA9SM95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0AAA9SM95-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVTLWLEVPSVSN", "length": 485, "header": "tr|A0AAA9SM95-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=1 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84043623, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110108.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110108.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087485.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087485.1" } ] } }, { "isoform_ac": "A0AAA9SVA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0AAA9SVA7-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVRTCSQAQ", "length": 481, "header": "tr|A0AAA9SVA7-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=1 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84060901, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111525.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111525.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088120.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088120.1" } ] } }, { "isoform_ac": "A0AAA9SY47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0AAA9SY47-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS", "length": 490, "header": "tr|A0AAA9SY47-1|A0AAA9SY47_BOVIN Isoform 1 of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=1 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84062442, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131659.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131659.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088242.1" } ] } }, { "isoform_ac": "A0AAA9T559-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#A0AAA9T559-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQFFLVSSRLPPPQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS", "length": 484, "header": "tr|A0AAA9T559-1|A0AAA9T559_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=1 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84062442, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093819.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093819.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091671.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091671.1" } ] } }, { "isoform_ac": "F1MM21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47/entry#F1MM21-1", "sequence": { "sequence": "MAQGSGDQRAVGIADPEESSPNMIVYRKIEDIITKMQDDKTGGVPVRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYVFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQSQSPVHIPSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDIALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVARRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVCCWRRVRMAAAFHPRGGFLPAVGAAPA", "length": 501, "header": "tr|F1MM21-1|A0AAA9SY47_BOVIN Computationally mapped isoform of Regulator of G protein signaling 6 OS=Bos taurus OX=9913 GN=RGS6 PE=4 SV=4 CANONICAL=A0AAA9SY47-1" }, "locus": { "chromosome": "10", "start_pos": 84056675, "end_pos": 83482330, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018891.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018891.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018891.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018891.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517545", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517545", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "negative regulation of signal transduction", "id": "GO:0009968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" }, { "name": "regulation of G protein-coupled receptor signaling pathway", "id": "GO:0008277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SY47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 115, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SY47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY47" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 336, "end_pos": 451, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 211, "end_pos": 213 }, { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0U8-1", "uniprot_ac": "A0AAA9T0U8", "uniprot_id": "A0AAA9T0U8_BOVIN", "mass": { "chemical_mass": 12293.0, "monoisotopic_mass": 12293.0 }, "refseq": { "ac": "NP_001421743", "name": "beta-microseminoprotein isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421743" }, "gene_names": [ { "name": "MSMB", "type": "recommended", "evidence": [ { "id": "A0AAA9T0U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8" } ] }, { "name": "MSMB", "type": "synonym", "evidence": [ { "id": "NP_001421743", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421743" } ] } ], "protein_names": [ { "name": "Beta-microseminoprotein", "type": "recommended", "evidence": [ { "id": "A0AAA9T0U8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#names_and_taxonomy" } ] }, { "name": "beta-microseminoprotein isoform 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001421743", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421743" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MSMB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8", "locus": { "chromosome": "28", "start_pos": 44061316, "end_pos": 44072018, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011660", "url": "https://www.ensembl.org/id/ENSBTAG00000011660" } ] } } ], "crossref": [ { "id": "A0AAA9T0U8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0U8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011660", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011660", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616019", "url": "https://www.ncbi.nlm.nih.gov/gene/616019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ETEIICC", "url": "https://omabrowser.org/oma/group/ETEIICC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUH6", "url": "https://www.orthodb.org/?gene=A0A3Q1LUH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MDF2", "url": "https://www.orthodb.org/?gene=F1MDF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3X8E3", "url": "https://www.orthodb.org/?gene=G3X8E3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10500", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10500", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10500:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10500:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421743", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUH6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUH6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDF2", "url": "https://www.uniprot.org/uniprotkb/F1MDF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDF2-1", "url": "https://www.uniprot.org/uniprotkb/F1MDF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X8E3", "url": "https://www.uniprot.org/uniprotkb/G3X8E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X8E3-1", "url": "https://www.uniprot.org/uniprotkb/G3X8E3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNALLFSFVVLATFVTLCNAQCYFIPNESSASNGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 111, "header": "tr|A0AAA9T0U8-1|A0AAA9T0U8_BOVIN Isoform 1 of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=1 CANONICAL=A0AAA9T0U8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#A0A3Q1LUH6-1", "sequence": { "sequence": "AAQNALLFSFVVLATFVTLCNAQCYFIPNESSASNGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 113, "header": "tr|A0A3Q1LUH6-1|A0AAA9T0U8_BOVIN Computationally mapped isoform of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=2 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44071147, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079782.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079782.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058883.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058883.2" } ] } }, { "isoform_ac": "A0AAA9RW65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#A0AAA9RW65-1", "sequence": { "sequence": "SSIGFDHFSCASHLGRLNALLFSFVVLATFVTLCNAQCYFIPNESSASNGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 127, "header": "tr|A0AAA9RW65-1|A0AAA9T0U8_BOVIN Computationally mapped isoform of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=1 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44070274, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075297.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075297.1" } ] } }, { "isoform_ac": "A0AAA9T0U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#A0AAA9T0U8-1", "sequence": { "sequence": "MNALLFSFVVLATFVTLCNAQCYFIPNESSASNGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 111, "header": "tr|A0AAA9T0U8-1|A0AAA9T0U8_BOVIN Isoform 1 of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=1 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44071703, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104880.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104880.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092418.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092418.1" } ] } }, { "isoform_ac": "A0AAA9T9C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#A0AAA9T9C9-1", "sequence": { "sequence": "AEDYSKEENRESRCSLKSWCELNVQRNALLFSFVVLATFVTLCNAQCYFIPNESSASNGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 136, "header": "tr|A0AAA9T9C9-1|A0AAA9T9C9_BOVIN Computationally mapped isoform of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=1 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44069707, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109140.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109140.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095306.1" } ] } }, { "isoform_ac": "A0AAA9TR34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#A0AAA9TR34-1", "sequence": { "sequence": "MPTLSLPRLLCLQNALLFSFVVLATFVTLCNAQCYFIPNESSASNGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 123, "header": "tr|A0AAA9TR34-1|A0AAA9TR34_BOVIN Computationally mapped isoform of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=1 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44070553, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101048.1" } ] } }, { "isoform_ac": "F1MDF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#F1MDF2-1", "sequence": { "sequence": "MGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 38, "header": "tr|F1MDF2-1|A0AAA9T0U8_BOVIN Computationally mapped isoform of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=3 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44061558, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015482.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015482.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015482.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015482.5" } ] } }, { "isoform_ac": "G3X8E3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8/entry#G3X8E3-1", "sequence": { "sequence": "MNALLFSFVVLATFVTLCNAQCYFIPNESSASNGDLPDPGIEARSPALAGCKDLSGVTHELKSDWKTENCESCHCSNDGIECCNTAAIPMGYDRDKCQAVFNKETCTYTVLEKKDPLKNCTVTAWVL", "length": 127, "header": "tr|G3X8E3-1|G3X8E3_BOVIN Computationally mapped isoform of Beta-microseminoprotein OS=Bos taurus OX=9913 GN=MSMB PE=3 SV=3 CANONICAL=A0AAA9T0U8-1" }, "locus": { "chromosome": "28", "start_pos": 44071703, "end_pos": 44061445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065899.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065899.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055661.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055661.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A2C9F3B6-1", "protein_name": "Beta-microseminoprotein", "gene_name": "MSMB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHMPERTPAHHNEILLGTLVVLATFVTLCNSQCYFIPNQSLKPNECQDLKGVSHPLNSVWKTKDCEECTCGQDAISCCNTAAIPTGYDTNKCQKILNKKTCTYTVVEKKDPGKTCDVTGWVL", "length": 122 }, "evidence": [ { "id": "A0AAA9T0U8", "url": "https://omabrowser.org/oma/group/A0AAA9T0U8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZWT8-1", "protein_name": "Microseminoprotein beta", "gene_name": "MSMB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKTFLACLLVLSVSVSMSNASCYFLPLNPVKRGDEIIGCYDMKGEPHEFNTHWKTKDCLECSCSNSGISCCTAYATPVNFDEEKCISIFNNTACAYEVVEKADHSKTCEVHEWVG", "length": 115 }, "evidence": [ { "id": "A0AAA9T0U8", "url": "https://omabrowser.org/oma/group/A0AAA9T0U8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O08540-1", "protein_name": "Beta-microseminoprotein", "gene_name": "Msmb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAWLGSLLFLATMVIASKAVCSIENREIFPNQMSDDCMDADGNKHFLNTPWKKNCTWCSCDKTSITCCTNATRPLSYDKDNCDVQFHPENCTYSVVDRKNPGKTCRVDSWTM", "length": 113 }, "evidence": [ { "id": "A0AAA9T0U8", "url": "https://omabrowser.org/oma/group/A0AAA9T0U8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P08118-1", "protein_name": "Beta-microseminoprotein", "gene_name": "MSMB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII", "length": 114 }, "evidence": [ { "id": "A0AAA9T0U8", "url": "https://omabrowser.org/oma/group/A0AAA9T0U8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97580-1", "protein_name": "Beta-microseminoprotein", "gene_name": "Msmb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKARLGSLLVLATLVTASNAACSIQRLKRLPNEKSDECTDVDGGKHVLNTYWQKNCEWCFCEKTAITCCTKTLIPVSYDKKRCQRQFHSENCTYSVVERTNPGKTCPVNGWTI", "length": 113 }, "evidence": [ { "id": "A0AAA9T0U8", "url": "https://omabrowser.org/oma/group/A0AAA9T0U8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 27, "end_pos": 29 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SY84-1", "uniprot_ac": "A0AAA9SY84", "uniprot_id": "A0AAA9SY84_BOVIN", "mass": { "chemical_mass": 43333.0, "monoisotopic_mass": 43333.0 }, "refseq": { "ac": "XP_002689395", "name": "cyclin-J-like protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689395" }, "gene_names": [ { "name": "CCNJL", "type": "recommended", "evidence": [ { "id": "A0AAA9SY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ] }, { "name": "CCNJL", "type": "synonym", "evidence": [ { "id": "XP_002689395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689395" } ] } ], "protein_names": [ { "name": "Cyclin-J-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#names_and_taxonomy" } ] }, { "name": "cyclin-J-like protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689395" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNJL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84", "locus": { "chromosome": "7", "start_pos": 71769124, "end_pos": 71876832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046343", "url": "https://www.ensembl.org/id/ENSBTAG00000046343" } ] } } ], "crossref": [ { "id": "A0AAA9SY84", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SY84", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046343", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046343", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20528", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20528", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20529", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20529", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100296837", "url": "https://www.ncbi.nlm.nih.gov/gene/100296837", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296837", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296837", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDLCLPT", "url": "https://omabrowser.org/oma/group/WDLCLPT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV46", "url": "https://www.orthodb.org/?gene=A0A3Q1LV46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02984", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02984", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689395", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689395", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV46", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV46-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E6L8", "url": "https://www.uniprot.org/uniprotkb/G5E6L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E6L8-1", "url": "https://www.uniprot.org/uniprotkb/G5E6L8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRHCLAATYGSSYFSGGHAFPAGCFDR", "length": 386, "header": "tr|A0AAA9SY84-1|A0AAA9SY84_BOVIN Isoform 1 of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=1 CANONICAL=A0AAA9SY84-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#A0A3Q1LV46-1", "sequence": { "sequence": "MMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRLLLGSSHWSDIAFNPGNWICLLVGVRGKIQPNQRWERGK", "length": 400, "header": "tr|A0A3Q1LV46-1|A0AAA9SY84_BOVIN Computationally mapped isoform of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=2 CANONICAL=A0AAA9SY84-1" }, "locus": { "chromosome": "7", "start_pos": 71875626, "end_pos": 71769124, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064470.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064470.2" } ] } }, { "isoform_ac": "A0AAA9SDT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#A0AAA9SDT6-1", "sequence": { "sequence": "AIIACSKGLQLPQTGHQCGLAGAVFPAELPFPLHLQQELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRHCLAATYGSSYFSGGHAFPAGCFDR", "length": 401, "header": "tr|A0AAA9SDT6-1|A0AAA9SY84_BOVIN Computationally mapped isoform of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=1 CANONICAL=A0AAA9SY84-1" }, "locus": { "chromosome": "7", "start_pos": 71852132, "end_pos": 71814230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093544.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093544.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080536.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080536.1" } ] } }, { "isoform_ac": "A0AAA9SHT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#A0AAA9SHT0-1", "sequence": { "sequence": "AQRRCAGFATSAKELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRHCLAATYGSSYFSGGHAFPAGCFDR", "length": 377, "header": "tr|A0AAA9SHT0-1|A0AAA9SY84_BOVIN Computationally mapped isoform of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=1 CANONICAL=A0AAA9SY84-1" }, "locus": { "chromosome": "7", "start_pos": 71854815, "end_pos": 71814230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129352.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129352.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085774.1" } ] } }, { "isoform_ac": "A0AAA9SM56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#A0AAA9SM56-1", "sequence": { "sequence": "TCDSYVSGIGRRVLYHLSTTYRLRPCPALEPALFKHTLPLWLFQGLQLPQTGHQCGLAGAVFPAELPFPLHLQQELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRHCLAATYGSSYFSGGHAFPAGCFDR", "length": 438, "header": "tr|A0AAA9SM56-1|A0AAA9SY84_BOVIN Computationally mapped isoform of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=1 CANONICAL=A0AAA9SY84-1" }, "locus": { "chromosome": "7", "start_pos": 71851362, "end_pos": 71814230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110281.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110281.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085017.1" } ] } }, { "isoform_ac": "A0AAA9SY84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#A0AAA9SY84-1", "sequence": { "sequence": "MMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRHCLAATYGSSYFSGGHAFPAGCFDR", "length": 386, "header": "tr|A0AAA9SY84-1|A0AAA9SY84_BOVIN Isoform 1 of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=1 CANONICAL=A0AAA9SY84-1" }, "locus": { "chromosome": "7", "start_pos": 71875626, "end_pos": 71814230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088697.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088697.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091423.1" } ] } }, { "isoform_ac": "G5E6L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84/entry#G5E6L8-1", "sequence": { "sequence": "GFPWLVDASLCLCLLSHGVLSELKLPTFRAHSPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFLDRYDITTSKQLYAVAVSCLLLASKFEDREDHVPKLEQINSTRILSSQNFSLTRKELLSTELLLLEAFGWNLCLPTPAHFLDYYLLASVSQKDHHCHSWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPGSPTQVLFQPPAYPGLSQPSATALAQFQNPVQDLCLAYRDSLQAHHRSGTLLSGGTNSSLHALYPTLQPLDVCPVPLPASFSMQMAIATEPRHCLAATYGSSYFSGGHAFPAGCFDR", "length": 385, "header": "tr|G5E6L8-1|G5E6L8_BOVIN Computationally mapped isoform of Cyclin-J-like protein OS=Bos taurus OX=9913 GN=CCNJL PE=3 SV=3 CANONICAL=A0AAA9SY84-1" }, "locus": { "chromosome": "7", "start_pos": 71874600, "end_pos": 71814230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064223.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064223.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055655.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055655.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296837", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296837", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LPN6-1", "protein_name": "Cyclin-J-like protein", "gene_name": "Ccnjl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MREARPPIPRAREGGPRRPELRAAAGPSAGRGAPVAGRDGLRRRRSRAREARGRAATGGHYVPGAGRDPPPADPHSGTAMRESLPGSRGAPQDPDSLISAAVMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSRHCHLCPSARHLAIYLLDHFMDQYNVTTSKQLYTVAVSCLLLASKFEDREDRVPKLDQINSTRILSSHNFSLTKKELLTTELLLLEAFSWDLCLPTPAHFLDYYLLASISQKDHHCHTWPTTCLRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRVSNYSLEHLSTCIEILLVAYDNVLKDAVAVKSQALAMVPSSSSAPTQVLFQPPTYPSLSQPPPTTLAQFQSPAQDLCLAYRDSLQAHRSGTLLSGDTGPSLHTPYPTLQPLDMCPVPVPASLSMQMAIAAEPRHCLTATYGSSYFSGSHMFPTGCFDS", "length": 489 }, "evidence": [ { "id": "A0AAA9SY84", "url": "https://omabrowser.org/oma/group/A0AAA9SY84/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SRT8-1", "protein_name": "Cyclin-J-like protein", "gene_name": "Ccnjl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVDILTLLSRHCHLCPSARHLAIYLLDHFMDQYNITTSKQLYTVAVSCLLLASKFEDREDRVPKLEQINNTRILSSQNFSLTKKELLTTELLLLEAFSWDLCLPTPAHFLDYYLLASISQKDHHCHAWPTTCLRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRVSSYSLEHLSTCIEILLVAYDNVLKDAVAVKSQTLAMVPGSSSAPAQVLFQPPTYPTLSQPPPTTLAQFQSPAQDLCLAYRDSLQAHRSGGLLSGDTGPSLHTPYPTLQPLDMCPVPVPASLSMQMAIAAEPRHCLTASYGSSYFSGSHMFPAGCFDS", "length": 387 }, "evidence": [ { "id": "A0AAA9SY84", "url": "https://omabrowser.org/oma/group/A0AAA9SY84/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VZP3-1", "protein_name": "Cyclin J, isoform A", "gene_name": "CycJ", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEQKVAAEQNIFVVDRKLKKTCPQADVERLAKTHWLTDYARDIFLTMREQELSRRPLFYLSPQLNERRRMLQLLKLATSAHKLSRCALHLAVYYMDRFVDYYKIRPDKLLLVAITCLHIAAQIENTDAFIPRYSEMNRLVKNAYTAFEYKAVERKILCFLNFELIRPTTASFVELFACSFLTRSDFKNYIEMLDEYERNHHTQPYQRYISFEEMLSILAQLLLRMADYTLYISRFANDLPSLLAAACIAAVRQVSGVRRWSEYLVGLTSYTEANVEPYMNVLTDYYYYHVIQTDYGSPSVQTNQSLASPDSGFEESFTENTNLVVSDEVVTVETYNIITVQLQDPSPHSSTFLPKEQTNLKRSRFEDDTENQHPLKHAKVESVAKD", "length": 386 }, "evidence": [ { "id": "A0AAA9SY84", "url": "https://omabrowser.org/oma/group/A0AAA9SY84/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" }, { "id": "SM01332", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01332" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin C-terminal", "eco_id": "ECO_0000259", "start_pos": 145, "end_pos": 280, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY84" }, { "id": "SM00385", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00385" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-like", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 136, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 119, "end_pos": 121 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 326, "end_pos": 328 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXE8-1", "uniprot_ac": "A0AAA9SXE8", "uniprot_id": "A0AAA9SXE8_BOVIN", "mass": { "chemical_mass": 57826.0, "monoisotopic_mass": 57826.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "DUF5523 domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SXE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8", "locus": {} } ], "crossref": [ { "id": "A0AAA9SXE8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041510", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041510", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20837:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20837:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M327", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M327", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M327-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M327-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBL4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S311", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S311", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S311-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S311-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCT3", "url": "https://www.uniprot.org/uniprotkb/E1BCT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCT3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQESFSYLASEFEETDTEIVNPITVIPQLSFTAELTNLSRCSLYEQKRRAKIQKLKYFIKILYNDKQVSCTSVSPLQFDFKVMFQQIFNIQLIYWPETICLEEYESQIEKDMSISDVNSITAQRNNSANFLKKVLGYAYLFDIIHVSPQT", "length": 495, "header": "tr|A0AAA9SXE8-1|A0AAA9SXE8_BOVIN Isoform 1 of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SXE8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M327-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0A3Q1M327-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQESFSYLASEFEETDTEIVNPITVIPQLSFTAELTNLSRCSLNMKVR", "length": 393, "header": "tr|A0A3Q1M327-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17358769, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086651.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086651.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064476.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064476.2" } ] } }, { "isoform_ac": "A0A3Q1MX71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0A3Q1MX71-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQESFSYLASEFEETDTEIVNPITVIPQLSFTAELTNLSRCSLCALSS", "length": 393, "header": "tr|A0A3Q1MX71-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17339063, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084945.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084945.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060279.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060279.2" } ] } }, { "isoform_ac": "A0A3Q1NBL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0A3Q1NBL4-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQEMCPFFLRKMELKNFVF", "length": 364, "header": "tr|A0A3Q1NBL4-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17339095, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079379.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079379.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068720.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068720.2" } ] } }, { "isoform_ac": "A0AAA9RX96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0AAA9RX96-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKMNG", "length": 236, "header": "tr|A0AAA9RX96-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17322217, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075810.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075810.1" } ] } }, { "isoform_ac": "A0AAA9S311-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0AAA9S311-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQEVLGYAYLFDIIHVSPQT", "length": 365, "header": "tr|A0AAA9S311-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17367321, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114480.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114480.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079480.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079480.1" } ] } }, { "isoform_ac": "A0AAA9SQI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0AAA9SQI8-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKFQVYSQVIPL", "length": 243, "header": "tr|A0AAA9SQI8-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17318822, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096590.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096590.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087624.1" } ] } }, { "isoform_ac": "A0AAA9SXE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0AAA9SXE8-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQESFSYLASEFEETDTEIVNPITVIPQLSFTAELTNLSRCSLYEQKRRAKIQKLKYFIKILYNDKQVSCTSVSPLQFDFKVMFQQIFNIQLIYWPETICLEEYESQIEKDMSISDVNSITAQRNNSANFLKKVLGYAYLFDIIHVSPQT", "length": 495, "header": "tr|A0AAA9SXE8-1|A0AAA9SXE8_BOVIN Isoform 1 of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17367321, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103982.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103982.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087978.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087978.1" } ] } }, { "isoform_ac": "A0AAA9T5U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#A0AAA9T5U8-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRKLKALTDATKLANENSEISQLTRKSLQDYYWQISDTKQLYELEKEKDFSLLHSILRTWKQIKSLRQRQGFTSTSVKLQFQRLKMNKCDEQKQELSKMSGTEKKTEGKAFKNRKKQEEYESQIEKDMSISDVNSITAQRNNSANFLKKVLGYAYLFDIIHVSPQT", "length": 396, "header": "tr|A0AAA9T5U8-1|A0AAA9T5U8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17367321, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123707.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123707.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093217.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093217.1" } ] } }, { "isoform_ac": "E1BCT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8/entry#E1BCT3-1", "sequence": { "sequence": "MSEDTDNVAVEENVDKHLPKDLNVEENRNIIETLRGKVREKLKNAKINQGEKSSTQLLIDNKVYQWSKAEVPLDEGLSFFILSGEEDSAIGQSAEQNFAEGQDEDFVEEVIFPDLLEVKAADYEDYEEQIKKQQANIFVPSSSPVINQLKLPEDMMPRILEEEGFYIQKKPEIYKKTCNKMENRLLKLEEGKCWFEESGEIMSLPSPIRRSWNFRLNISKEPLNPALKTMYRK", "length": 233, "header": "tr|E1BCT3-1|A0AAA9SXE8_BOVIN Computationally mapped isoform of DUF5523 domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=A0AAA9SXE8-1" }, "locus": { "chromosome": "26", "start_pos": 17308783, "end_pos": 17299670, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027433.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027433.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027433.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027433.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8" }, { "id": "PF15625", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15625" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CC2D2A N-terminal C2", "eco_id": "ECO_0000259", "start_pos": 369, "end_pos": 457, "start_aa": "Thr", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SXE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE8" }, { "id": "PF17661", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17661" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF5523", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 233, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 382, "end_pos": 384 }, { "start_pos": 470, "end_pos": 472 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYG6-1", "uniprot_ac": "A0AAA9SYG6", "uniprot_id": "A0AAA9SYG6_BOVIN", "mass": { "chemical_mass": 35449.0, "monoisotopic_mass": 35449.0 }, "refseq": { "ac": "NP_001179046", "name": "G-protein coupled receptor 146", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179046" }, "gene_names": [ { "name": "GPR146", "type": "recommended", "evidence": [ { "id": "A0AAA9SYG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6" } ] }, { "name": "GPR146", "type": "synonym", "evidence": [ { "id": "NP_001179046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179046" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 146", "type": "synonym", "evidence": [ { "id": "A0AAA9SYG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 146", "type": "synonym", "evidence": [ { "id": "NP_001179046", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179046" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR146", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6", "locus": { "chromosome": "25", "start_pos": 41711893, "end_pos": 41726024, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046014", "url": "https://www.ensembl.org/id/ENSBTAG00000046014" } ] } } ], "crossref": [ { "id": "ENSBTAG00000046014", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046014", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506876", "url": "https://www.ncbi.nlm.nih.gov/gene/506876", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506876", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506876", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YICSHVA", "url": "https://omabrowser.org/oma/group/YICSHVA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M726", "url": "https://www.orthodb.org/?gene=A0A3Q1M726", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N1W2", "url": "https://www.orthodb.org/?gene=G3N1W2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24226:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24226:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179046", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M726", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M726", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M726-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M726-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1W2", "url": "https://www.uniprot.org/uniprotkb/G3N1W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1W2-1", "url": "https://www.uniprot.org/uniprotkb/G3N1W2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSCPLNGTDGEDPLPCLHVQRALSALSLLYLLGGVPLGLGYNALLLLANLHDPGSMTMPDVYFANMAAAGLLLCALAPAHLLGPGAAGGAAWDLGSEVHVSLLVLFNVAALVTLYSTALLGLDCYIERALPRTYMSSVYNTRHVCGFVWGGALLAGFSSLLFHICSHVAARLVECSRMRDAAAADAIMLLVGYLVPGLAALYALALLVRVRKEDTPLDRDAGRPDPSAHRLLVATTCAQFGLWTPHYLMLLGRTVLAARGKPLDGHHVGTLLLAKDLSRFLAFASSAVVPLLYRHIDRNFPGKLRRLMKKLRRGHQNCSPDQAGAQPVTT", "length": 331, "header": "tr|A0AAA9SYG6-1|A0AAA9SYG6_BOVIN Isoform 1 of G protein-coupled receptor 146 OS=Bos taurus OX=9913 GN=GPR146 PE=4 SV=1 CANONICAL=A0AAA9SYG6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M726-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6/entry#A0A3Q1M726-1", "sequence": { "sequence": "MELRSPWQPAMWSCPLNGTDGEDPLPCLHVQRALSALSLLYLLGGVPLGLGYNALLLLANLHDPGSMTMPDVYFANMAAAGLLLCALAPAHLLGPGAAGGAAWDLGSEVHVSLLVLFNVAALVTLYSTALLGLDCYIERALPRTYMSSVYNTRHVCGFVWGGALLAGFSSLLFHICSHVAARLVECSRMRDAAAADAIMLLVGYLVPGLAALYALALLVRVRKEDTPLDRDAGRPDPSAHRLLVATTCAQFGLWTPHYLMLLGRTVLAARGKPLDGHHVGTLLLAKDLSRFLAFASSAVVPLLYRHIDRNFPGKLRRLMKKLRRGHQNCSPDQAGAQPVTT", "length": 341, "header": "tr|A0A3Q1M726-1|A0AAA9SYG6_BOVIN Computationally mapped isoform of G protein-coupled receptor 146 OS=Bos taurus OX=9913 GN=GPR146 PE=4 SV=1 CANONICAL=A0AAA9SYG6-1" }, "locus": { "chromosome": "25", "start_pos": 41723822, "end_pos": 41715517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080668.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080668.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066147.1" } ] } }, { "isoform_ac": "A0AAA9RW59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6/entry#A0AAA9RW59-1", "sequence": { "sequence": "MIRENRQNSQRVGGANYLQVELIPLGETGCGDRRTTSTAKEQARMLEPTSPPTPGHTTSGLGSPAAGIAARPRPQACTCQARPCSVDKGWLQAWLGTPATEEGCPRPAMWSCPLNGTDGEDPLPCLHVQRALSALSLLYLLGGVPLGLGYNALLLLANLHDPGSMTMPDVYFANMAAAGLLLCALAPAHLLGPGAAGGAAWDLGSEVHVSLLVLFNVAALVTLYSTALLGLDCYIERALPRTYMSSVYNTRHVCGFVWGGALLAGFSSLLFHICSHVAARLVECSRMRDAAAADAIMLLVGYLVPGLAALYALALLVRVRKEDTPLDRDAGRPDPSAHRLLVATTCAQFGLWTPHYLMLLGRTVLAARGKPLDGHHVGTLLLAKDLSRFLAFASSAVVPLLYRHIDRNFPGKLRRLMKKLRRGHQNCSPDQAGAQPVTT", "length": 439, "header": "tr|A0AAA9RW59-1|A0AAA9SYG6_BOVIN Computationally mapped isoform of G protein-coupled receptor 146 OS=Bos taurus OX=9913 GN=GPR146 PE=4 SV=1 CANONICAL=A0AAA9SYG6-1" }, "locus": { "chromosome": "25", "start_pos": 41720169, "end_pos": 41715517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100849.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100849.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075286.1" } ] } }, { "isoform_ac": "A0AAA9SYG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6/entry#A0AAA9SYG6-1", "sequence": { "sequence": "MWSCPLNGTDGEDPLPCLHVQRALSALSLLYLLGGVPLGLGYNALLLLANLHDPGSMTMPDVYFANMAAAGLLLCALAPAHLLGPGAAGGAAWDLGSEVHVSLLVLFNVAALVTLYSTALLGLDCYIERALPRTYMSSVYNTRHVCGFVWGGALLAGFSSLLFHICSHVAARLVECSRMRDAAAADAIMLLVGYLVPGLAALYALALLVRVRKEDTPLDRDAGRPDPSAHRLLVATTCAQFGLWTPHYLMLLGRTVLAARGKPLDGHHVGTLLLAKDLSRFLAFASSAVVPLLYRHIDRNFPGKLRRLMKKLRRGHQNCSPDQAGAQPVTT", "length": 331, "header": "tr|A0AAA9SYG6-1|A0AAA9SYG6_BOVIN Isoform 1 of G protein-coupled receptor 146 OS=Bos taurus OX=9913 GN=GPR146 PE=4 SV=1 CANONICAL=A0AAA9SYG6-1" }, "locus": { "chromosome": "25", "start_pos": 41716509, "end_pos": 41715517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095777.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095777.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090410.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090410.1" } ] } }, { "isoform_ac": "G3N1W2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6/entry#G3N1W2-1", "sequence": { "sequence": "MGALTRQRAPLPRGGLSRARGHDRAASPEDKSPAMWSCPLNGTDGEDPLPCLHVQRALSALSLLYLLGGVPLGLGYNALLLLANLHDPGSMTMPDVYFANMAAAGLLLCALAPAHLLGPGAAGGAAWDLGSEVHVSLLVLFNVAALVTLYSTALLGLDCYIERALPRTYMSSVYNTRHVCGFVWGGALLAGFSSLLFHICSHVAARLVECSRMRDAAAADAIMLLVGYLVPGLAALYALALLVRVRKEDTPLDRDAGRPDPSAHRLLVATTCAQFGLWTPHYLMLLGRTVLAARGKPLDGHHVGTLLLAKDLSRFLAFASSAVVPLLYRHIDRNFPGKLRRLMKKLRRGHQNCSPDQAGAQPVTT", "length": 365, "header": "tr|G3N1W2-1|G3N1W2_BOVIN Computationally mapped isoform of G protein-coupled receptor 146 OS=Bos taurus OX=9913 GN=GPR146 PE=4 SV=2 CANONICAL=A0AAA9SYG6-1" }, "locus": { "chromosome": "25", "start_pos": 41720932, "end_pos": 41715517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064866.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064866.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055866.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055866.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506876", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506876", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287APZ3-1", "protein_name": "G protein-coupled receptor 146", "gene_name": "GPR146", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWSCGPLNGSGGEDQLLCQHAQRALPALSLLYLLVGVPLGLGYNALLLLVNLHDPAGMTMPDVYFANMAVAGLVLGALAPAHLLGPGASGWAVWDLGSEVRVTLLVLFNVSALVALYSTALLGLDCYIERALPRSYMSSVYNTRHVCGFVWGGALLASFSSLLSYICSHVAARVAECSRMQDAQAADAILVLIGYLVPALAALYALVLIARVRKQATPLDQDAGGLDPAAHRLLVATVCTQFGLWTPHYLTLLGRTVLAARGKPVDGQHLGVLLLARDLSRLLAFCSSSTLPLLYRYINRSFPGKLQRLLKKMHRGHRSCSLDQAGAPPVTA", "length": 332 }, "evidence": [ { "id": "A0AAA9SYG6", "url": "https://omabrowser.org/oma/group/A0AAA9SYG6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZRF1-1", "protein_name": "G protein-coupled receptor 146", "gene_name": "GPR146", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWSCETLNSTDNREDQHLCQDFHFVLSIFSLLYLIICFPIGLCYNGLLVLVNLYNKATMTMPDVYFVNMAIAGLIINALAPMYLLGLANTKWAIWNSNNEVYITLLILFNVSSLVTMYSTTLLSLDYYIERALPRTYMSSVYNTKHVCGFIWGGAMLTSFSSLLFYVCNHVSTKIIECSKMQNKEAADAIMVFIGYVVPAVAVLYALILILRIRKEATPLDQDTGRLDPSVHRLLIATVCTQFTLWTPYYVTLLVSTFTYARGRPADENYSRILHFTKILSKFLAFSSSFVMPLLYRYINKNFPNKLRRLLKKIHCGNQGCSHERTVVQQVMT", "length": 333 }, "evidence": [ { "id": "A0AAA9SYG6", "url": "https://omabrowser.org/oma/group/A0AAA9SYG6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZIS6-1", "protein_name": "G-protein coupled receptor 146", "gene_name": "Gpr146", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLFYLGAGVPVGLGYNALLVLANLASKNSMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHVTLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFSSLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTPLDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLVSRGRTVEGHYLGILQVAKDLAKFLAFSSSSVTPLLYRYINKAFPSKLRRLVKKIHCGRRHCSPDPAGIQQVMAQA", "length": 333 }, "evidence": [ { "id": "A0AAA9SYG6", "url": "https://omabrowser.org/oma/group/A0AAA9SYG6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96CH1-1", "protein_name": "G protein-coupled receptor 146", "gene_name": "GPR146", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA", "length": 333 }, "evidence": [ { "id": "A0AAA9SYG6", "url": "https://omabrowser.org/oma/group/A0AAA9SYG6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99LE2-1", "protein_name": "G protein-coupled receptor 146", "gene_name": "Gpr146", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLLYLGAGVPVSLGYNALLVLANLASKNTMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHVTLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFSSLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTPLDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLTSRGRTVEGHYLGILQVAKDLAKFLAFSSSSVTPLLYRYINKAFPGKLRRLMKKMHCGRRHCSPDPSGIQQVMAQA", "length": 333 }, "evidence": [ { "id": "A0AAA9SYG6", "url": "https://omabrowser.org/oma/group/A0AAA9SYG6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 294, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 318, "end_pos": 320 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZH8-1", "uniprot_ac": "A0AAA9SZH8", "uniprot_id": "A0AAA9SZH8_BOVIN", "mass": { "chemical_mass": 54047.0, "monoisotopic_mass": 54047.0 }, "refseq": { "ac": "XP_005211887", "name": "N-acetylgalactosamine kinase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211887" }, "gene_names": [ { "name": "GALK2", "type": "recommended", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ] }, { "name": "GALK2", "type": "synonym", "evidence": [ { "id": "XP_005211887", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211887" } ] } ], "protein_names": [ { "name": "N-acetylgalactosamine kinase", "type": "recommended", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.157", "type": "synonym", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#names_and_taxonomy" } ] }, { "name": "GalNAc kinase", "type": "synonym", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#names_and_taxonomy" } ] }, { "name": "Galactokinase 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#names_and_taxonomy" } ] }, { "name": "N-acetylgalactosamine kinase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005211887", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211887" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GALK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8", "locus": { "chromosome": "10", "start_pos": 60924617, "end_pos": 61080535, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004011", "url": "https://www.ensembl.org/id/ENSBTAG00000004011" } ] } } ], "crossref": [ { "id": "A0AAA9SZH8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004011", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004011", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536133", "url": "https://www.ncbi.nlm.nih.gov/gene/536133", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M891", "url": "https://www.orthodb.org/?gene=A0A3Q1M891", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MFK7", "url": "https://www.orthodb.org/?gene=F1MFK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10457", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10457", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10457:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10457:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00288", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00288", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10509", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10509", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211887", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211887", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12617", "url": "https://www.rhea-db.org/rhea/12617", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M891", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M891", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M891-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M891-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFK7", "url": "https://www.uniprot.org/uniprotkb/F1MFK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPALSDCLGWIDVEAVRAFGSSRSRQNPWDVTRSLGWDRAVKSVQPCSLPRLLKLKEMFNSKFGSVPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHVLQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGFKGIQEHFGLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKHKSLPWKEVLRLEEVQAKLGISLEEMLLITEDALHPEPYSPEEICKCLGISLQELKTQILSPNTQDVLTFKLYQRAKHVYSEAARVLQFKKICEEAPDNVVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPAEKLSSFLANVHEAYYQRSNRSLAPEKQSLFATKPGGGALVFLEA", "length": 491, "header": "tr|A0AAA9SZH8-1|A0AAA9SZH8_BOVIN Isoform 1 of N-acetylgalactosamine kinase OS=Bos taurus OX=9913 GN=GALK2 PE=3 SV=1 CANONICAL=A0AAA9SZH8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M891-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#A0A3Q1M891-1", "sequence": { "sequence": "MATECPAVRRVQVAEHPRLLKLKEMFNSKFGSVPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHVLQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGFKGIQEHFGLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKTATANRDMQWGVAPGPCFRHVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKHKSLPWKEVLRLEEVQAKLGISLEEMLLITEDALHPEPYSPEEICKCLGISLQELKTQILSPNTQDVLTFKLYQRAKHVYSEAARVLQFKKICEEAPDNVVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPAEKLSSFLANVHEAYYQRSNRSLAPEKQSLFATKPGGGALVFLEA", "length": 478, "header": "tr|A0A3Q1M891-1|A0AAA9SZH8_BOVIN Computationally mapped isoform of N-acetylgalactosamine kinase OS=Bos taurus OX=9913 GN=GALK2 PE=3 SV=2 CANONICAL=A0AAA9SZH8-1" }, "locus": { "chromosome": "10", "start_pos": 61065939, "end_pos": 60924965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071449.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071449.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070103.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070103.2" } ] } }, { "isoform_ac": "A0AAA9SZH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#A0AAA9SZH8-1", "sequence": { "sequence": "MPALSDCLGWIDVEAVRAFGSSRSRQNPWDVTRSLGWDRAVKSVQPCSLPRLLKLKEMFNSKFGSVPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHVLQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGFKGIQEHFGLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKHKSLPWKEVLRLEEVQAKLGISLEEMLLITEDALHPEPYSPEEICKCLGISLQELKTQILSPNTQDVLTFKLYQRAKHVYSEAARVLQFKKICEEAPDNVVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPAEKLSSFLANVHEAYYQRSNRSLAPEKQSLFATKPGGGALVFLEA", "length": 491, "header": "tr|A0AAA9SZH8-1|A0AAA9SZH8_BOVIN Isoform 1 of N-acetylgalactosamine kinase OS=Bos taurus OX=9913 GN=GALK2 PE=3 SV=1 CANONICAL=A0AAA9SZH8-1" }, "locus": { "chromosome": "10", "start_pos": 61065872, "end_pos": 60924965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119432.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119432.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090828.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090828.1" } ] } }, { "isoform_ac": "F1MFK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8/entry#F1MFK7-1", "sequence": { "sequence": "MPILCDRLLKLKEMFNSKFGSVPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDMLIAVEPVKTHVLQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGFKGIQEHFGLSDLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGMNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAKHKSLPWKEVLRLEEVQAKLGISLEEMLLITEDALHPEPYSPEEICKCLGISLQELKTQILSPNTQDVLTFKLYQRAKHVYSEAARVLQFKKICEEAPDNVVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSIVPAEKLSSFLANVHEAYYQRSNRSLAPEKQSLFATKPGGGALVFLEA", "length": 447, "header": "tr|F1MFK7-1|A0AAA9SZH8_BOVIN Computationally mapped isoform of N-acetylgalactosamine kinase OS=Bos taurus OX=9913 GN=GALK2 PE=3 SV=2 CANONICAL=A0AAA9SZH8-1" }, "locus": { "chromosome": "10", "start_pos": 61080412, "end_pos": 60924965, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005236.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005236.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005236.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005236.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "pmid": "" }, { "name": "galactokinase activity", "id": "GO:0004335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "pmid": "" }, { "name": "N-acetylgalactosamine kinase activity", "id": "GO:0033858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033858", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "galactose metabolic process", "id": "GO:0006012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 398, "end_pos": 400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12617", "name": "", "equation": "N-acetyl-alpha-D-galactosamine + ATP = N-acetyl-alpha-D-galactosamine 1-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SZH8-1" ], "evidence": [ { "id": "12617", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12617" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SZH8", "gene_name": "GALK2", "activity": [ { "ec_number": "2.7.1.157", "activity": "N-acetyl-alpha-D-galactosamine + ATP = N-acetyl-alpha-D-galactosamine 1-phosphate + ADP + H(+).", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ] }, { "ec_number": "2.7.1.157", "activity": "", "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" }, { "id": "PF08544", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08544" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GHMP kinase C-terminal", "eco_id": "ECO_0000259", "start_pos": 390, "end_pos": 462, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" }, { "id": "PF00288", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00288" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GHMP kinase N-terminal", "eco_id": "ECO_0000259", "start_pos": 142, "end_pos": 229, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SZH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZH8" }, { "id": "PF10509", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10509" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Galactokinase N-terminal", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 106, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.157", "ec_name": "N-acetyl-alpha-D-galactosamine + ATP = N-acetyl-alpha-D-galactosamine 1-phosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.157" }, { "id": "2.7.1.157", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.157" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 198, "end_pos": 200 }, { "start_pos": 398, "end_pos": 400 }, { "start_pos": 466, "end_pos": 468 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYM9-1", "uniprot_ac": "A0AAA9SYM9", "uniprot_id": "A0AAA9SYM9_BOVIN", "mass": { "chemical_mass": 273078.0, "monoisotopic_mass": 273078.0 }, "refseq": { "ac": "XP_024850984", "name": "ankyrin repeat and KH domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850984" }, "gene_names": [ { "name": "ANKHD1", "type": "recommended", "evidence": [ { "id": "A0AAA9SYM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9" } ] }, { "name": "ANKHD1", "type": "synonym", "evidence": [ { "id": "XP_024850984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850984" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and KH domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SYM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and KH domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024850984", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850984" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKHD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9", "locus": { "chromosome": "7", "start_pos": 51724000, "end_pos": 51610894, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010871", "url": "https://www.ensembl.org/id/ENSBTAG00000010871" } ] } } ], "crossref": [ { "id": "ENSBTAG00000054857", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054857", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22503", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22503", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509490", "url": "https://www.ncbi.nlm.nih.gov/gene/509490", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23206:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23206:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00013", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00013", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024850984", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850984", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SYM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B719", "url": "https://www.uniprot.org/uniprotkb/E1B719", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B719-1", "url": "https://www.uniprot.org/uniprotkb/E1B719-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTDGGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPAPGVGGGSSGAGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAENSHSAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLDAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLTPPSQDQSQVPRVPMHTLAMVVPPQEPDRTLQENSPAVLGVQKGTSKQKSSSLQVADQDVLPPFHPYQPLECIVEETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSELGSNGTNSLELQKVSGNHQIIGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSSRVPTGSNSSSQNVECLTPEPCSQSPSNVASQSIPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLINRGAHIDVRNKKGNTPLWLASNGGHFEVVQLLVRSGADVDGADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENEEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHISLAQQKADKNKINGESKGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFTMDVNSSSDRRYPLLLLHSQEEKTSTAASKTPTRLEGEVNPNSLSTTYKSVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRSAVQLINALIQDPAKELEDLIPKNHIRTPASIKAIHANFSSGVGTTAASSKNAFPLGAPSLVTSQATTLSTFQPTNKLNKNVPANVRSSFPVSLPLAYPHPHFALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTGRLPNQNGTVLPSESTGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVITSMTSTCSSLPSVSSAPITSGQVPTTFLPASTSQAQLSSQKMESFSAMPAPKEKLSTQDQSTANLCPPSSTANSCSSSASNTPGAPETHPSGSPTPLSNNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLASPRLVAADNQDTSNLPQLAVPAPRVSHRLQPRGSFYSVVPNATIHQDPQSIFVTNPVPLTPPQGPPATVQLSSAMNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVAADASFTVQSAFLGSSVLGHLENVHPDNSKAPGFRSPSQRVSTSPVGLPSIDPSGSSPSSSSAPLTSFSSIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSASNSCDSPIPSVSSGSSSPLSATSAPPTLGQPKGGSASQDRKIPPPIGTERLARIRQGGSVAQAPVGTGFVAPVGHSGIWSFGVNAMSEGLSGWSQSVIGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASSFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPSWNPMIKVIQNSTECTDAQQIWPGTWAPHIGNMHLKYVN", "length": 2576, "header": "tr|A0AAA9SYM9-1|A0AAA9SYM9_BOVIN Isoform 1 of Ankyrin repeat and KH domain containing 1 OS=Bos taurus OX=9913 GN=ANKHD1 PE=4 SV=1 CANONICAL=A0AAA9SYM9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9/entry#A0AAA9SYM9-1", "sequence": { "sequence": "MLTDGGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPAPGVGGGSSGAGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAENSHSAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLDAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLTPPSQDQSQVPRVPMHTLAMVVPPQEPDRTLQENSPAVLGVQKGTSKQKSSSLQVADQDVLPPFHPYQPLECIVEETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSELGSNGTNSLELQKVSGNHQIIGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSSRVPTGSNSSSQNVECLTPEPCSQSPSNVASQSIPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLINRGAHIDVRNKKGNTPLWLASNGGHFEVVQLLVRSGADVDGADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENEEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHISLAQQKADKNKINGESKGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFTMDVNSSSDRRYPLLLLHSQEEKTSTAASKTPTRLEGEVNPNSLSTTYKSVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRSAVQLINALIQDPAKELEDLIPKNHIRTPASIKAIHANFSSGVGTTAASSKNAFPLGAPSLVTSQATTLSTFQPTNKLNKNVPANVRSSFPVSLPLAYPHPHFALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTGRLPNQNGTVLPSESTGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVITSMTSTCSSLPSVSSAPITSGQVPTTFLPASTSQAQLSSQKMESFSAMPAPKEKLSTQDQSTANLCPPSSTANSCSSSASNTPGAPETHPSGSPTPLSNNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLASPRLVAADNQDTSNLPQLAVPAPRVSHRLQPRGSFYSVVPNATIHQDPQSIFVTNPVPLTPPQGPPATVQLSSAMNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVAADASFTVQSAFLGSSVLGHLENVHPDNSKAPGFRSPSQRVSTSPVGLPSIDPSGSSPSSSSAPLTSFSSIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSASNSCDSPIPSVSSGSSSPLSATSAPPTLGQPKGGSASQDRKIPPPIGTERLARIRQGGSVAQAPVGTGFVAPVGHSGIWSFGVNAMSEGLSGWSQSVIGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASSFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPSWNPMIKVIQNSTECTDAQQIWPGTWAPHIGNMHLKYVN", "length": 2576, "header": "tr|A0AAA9SYM9-1|A0AAA9SYM9_BOVIN Isoform 1 of Ankyrin repeat and KH domain containing 1 OS=Bos taurus OX=9913 GN=ANKHD1 PE=4 SV=1 CANONICAL=A0AAA9SYM9-1" }, "locus": { "chromosome": "7", "start_pos": 51715783, "end_pos": 51611093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134546.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134546.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090475.1" } ] } }, { "isoform_ac": "E1B719-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9/entry#E1B719-1", "sequence": { "sequence": "MLTDGGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPAPGVGGGSSGAGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAENSHSAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLDAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAAGQAGGHEDYFGGHRSGQASGEGGL", "length": 576, "header": "tr|E1B719-1|E1B719_BOVIN Computationally mapped isoform of Ankyrin repeat and KH domain containing 1 OS=Bos taurus OX=9913 GN=ANKHD1 PE=4 SV=4 CANONICAL=A0AAA9SYM9-1" }, "locus": { "chromosome": "7", "start_pos": 51667126, "end_pos": 51611093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014440.8", "url": "https://www.ensembl.org/id/ENSBTAT00000014440.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014440.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014440.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2340, "start_aa": "Thr", "end_pos": 2340, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2340", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1026, "end_pos": 1028, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1166, "end_pos": 1168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1441, "end_pos": 1443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1562, "end_pos": 1564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1629, "end_pos": 1631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1635, "end_pos": 1637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1693, "end_pos": 1695, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1734, "end_pos": 1736, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1808, "end_pos": 1810, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1919, "end_pos": 1921, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1925, "end_pos": 1927, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1934, "end_pos": 1936, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2092, "end_pos": 2094, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2166, "end_pos": 2168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2204, "end_pos": 2206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2214, "end_pos": 2216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2548, "end_pos": 2550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 950, "end_pos": 952, "annotation": "n_glycosylation_sequon" }, { "start_pos": 958, "end_pos": 960, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM9" }, { "id": "SM00322", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00322" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "K Homology", "eco_id": "ECO_0000259", "start_pos": 1711, "end_pos": 1781, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 2340 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1026, "end_pos": 1028 }, { "start_pos": 1166, "end_pos": 1168 }, { "start_pos": 1441, "end_pos": 1443 }, { "start_pos": 1562, "end_pos": 1564 }, { "start_pos": 1629, "end_pos": 1631 }, { "start_pos": 1635, "end_pos": 1637 }, { "start_pos": 1693, "end_pos": 1695 }, { "start_pos": 1734, "end_pos": 1736 }, { "start_pos": 1808, "end_pos": 1810 }, { "start_pos": 1919, "end_pos": 1921 }, { "start_pos": 1925, "end_pos": 1927 }, { "start_pos": 1934, "end_pos": 1936 }, { "start_pos": 2092, "end_pos": 2094 }, { "start_pos": 2166, "end_pos": 2168 }, { "start_pos": 2204, "end_pos": 2206 }, { "start_pos": 2214, "end_pos": 2216 }, { "start_pos": 2548, "end_pos": 2550 }, { "start_pos": 950, "end_pos": 952 }, { "start_pos": 958, "end_pos": 960 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0H7-1", "uniprot_ac": "A0AAA9T0H7", "uniprot_id": "A0AAA9T0H7_BOVIN", "mass": { "chemical_mass": 42232.0, "monoisotopic_mass": 42232.0 }, "refseq": { "ac": "XP_005210219", "name": "paired box protein Pax-5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210219" }, "gene_names": [ { "name": "PAX5", "type": "recommended", "evidence": [ { "id": "A0AAA9T0H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ] }, { "name": "PAX5", "type": "synonym", "evidence": [ { "id": "XP_005210219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210219" } ] } ], "protein_names": [ { "name": "Paired box 5", "type": "synonym", "evidence": [ { "id": "A0AAA9T0H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#names_and_taxonomy" } ] }, { "name": "paired box protein Pax-5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005210219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210219" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7", "locus": { "chromosome": "8", "start_pos": 60997000, "end_pos": 61178211, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012498", "url": "https://www.ensembl.org/id/ENSBTAG00000012498" } ] } } ], "crossref": [ { "id": "A0AAA9T0H7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0H7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012498", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012498", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00131", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00131", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538371", "url": "https://www.ncbi.nlm.nih.gov/gene/538371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538371", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538371", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IXIQESP", "url": "https://omabrowser.org/oma/group/IXIQESP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM48", "url": "https://www.orthodb.org/?gene=A0A3Q1MM48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MWQ4", "url": "https://www.orthodb.org/?gene=F1MWQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45636", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45636", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45636:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45636:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00292", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00292", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8939245", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939245", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005210219", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM48", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1C4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T024", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T024", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T024-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T024-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWQ4", "url": "https://www.uniprot.org/uniprotkb/F1MWQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWQ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MWQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPTGQGSYSAPTLTGMVPGSDFSGSPYSHPQYPSYNDSWRFPNPGLLGSPYYYSAAAARGAAPPTAATAYDRH", "length": 392, "header": "tr|A0AAA9T0H7-1|A0AAA9T0H7_BOVIN Isoform 1 of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MM48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0A3Q1MM48-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPTGQGSYSAPTLTGMVPGSPYYYSAAAARGAAPPTAATAYDRH", "length": 363, "header": "tr|A0A3Q1MM48-1|A0AAA9T0H7_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=2 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081940.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081940.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072830.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072830.2" } ] } }, { "isoform_ac": "A0AAA9RVI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9RVI8-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQVPRTITALLPPEEPLRPQLPLPTTATDPQSQAGAKHF", "length": 297, "header": "tr|A0AAA9RVI8-1|A0AAA9T0H7_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127564.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127564.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076338.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076338.1" } ] } }, { "isoform_ac": "A0AAA9S1C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9S1C4-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGSDFSGSPYSHPQYPSYNDSWRFPNPGLLGSPYYYSAAAARGAAPPTAATAYDRH", "length": 358, "header": "tr|A0AAA9S1C4-1|A0AAA9T0H7_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107786.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107786.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078784.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078784.1" } ] } }, { "isoform_ac": "A0AAA9SG96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9SG96-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGSDFSGSPYSHPQYPSYNDSWRFPNPGLLGSPYYYSAAAARGAAPPTAATAYDRH", "length": 292, "header": "tr|A0AAA9SG96-1|A0AAA9T0H7_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082694.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082694.1" } ] } }, { "isoform_ac": "A0AAA9STK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9STK7-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPTGQGSYSAPTLTGMVPGSDFSGSPYSHPQYPSYNDSWRFPNPGLLGSPYYYSAAAARGAAPPTAATAYDRH", "length": 349, "header": "tr|A0AAA9STK7-1|A0AAA9T0H7_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135902.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135902.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089758.1" } ] } }, { "isoform_ac": "A0AAA9T024-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9T024-1", "sequence": { "sequence": "MEIHCKHDPFASMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPTGQGSYSAPTLTGMVPGSDFSGSPYSHPQYPSYNDSWRFPNPGLLGSPYYYSAAAARGAAPPTAATAYDRH", "length": 391, "header": "tr|A0AAA9T024-1|A0AAA9T024_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61169914, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100367.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100367.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089736.1" } ] } }, { "isoform_ac": "A0AAA9T0H7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9T0H7-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPTGQGSYSAPTLTGMVPGSDFSGSPYSHPQYPSYNDSWRFPNPGLLGSPYYYSAAAARGAAPPTAATAYDRH", "length": 392, "header": "tr|A0AAA9T0H7-1|A0AAA9T0H7_BOVIN Isoform 1 of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122049.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122049.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091204.1" } ] } }, { "isoform_ac": "A0AAA9TL53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#A0AAA9TL53-1", "sequence": { "sequence": "MDLEKNYPTPRTGRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQGVIFPGAPTATLSIPRTTTPGGSPTRGCSVPRTITALLPPEEPLRPQLPLPTTATDPQSQAGAKHF", "length": 326, "header": "tr|A0AAA9TL53-1|A0AAA9TL53_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=1 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61177865, "end_pos": 60998004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105590.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105590.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099157.1" } ] } }, { "isoform_ac": "F1MWQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7/entry#F1MWQ4-1", "sequence": { "sequence": "MEIHCKHDPFASMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTAEPIKPEQTADYSTMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGSPYYYSAAAARGAAPPTAATAYDRH", "length": 328, "header": "tr|F1MWQ4-1|A0AAA9T0H7_BOVIN Computationally mapped isoform of Paired box 5 OS=Bos taurus OX=9913 GN=PAX5 PE=4 SV=3 CANONICAL=A0AAA9T0H7-1" }, "locus": { "chromosome": "8", "start_pos": 61169914, "end_pos": 60998038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016584.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016584.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016584.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016584.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 285, "start_aa": "Thr", "end_pos": 285, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr285", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 384, "start_aa": "Thr", "end_pos": 384, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr384", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538371", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538371", "resource": "KEGG Pathway" }, { "id": "R-BTA-8939245", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939245", "resource": "Reactome", "description": "RUNX1 regulates transcription of genes involved in BCR signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LPW6-1", "protein_name": "Paired box 5", "gene_name": "Pax5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIHCKHDPFASMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGSLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH", "length": 390 }, "evidence": [ { "id": "A0AAA9T0H7", "url": "https://omabrowser.org/oma/group/A0AAA9T0H7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QGF8-1", "protein_name": "Paired box protein Pax-5", "gene_name": "pax5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDLDQKGPSLRIGRSGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVDKIADYKRQNPTMFAWEIRDRLLAERVCDNDSVPSVSSINRIIRTKVQQPPGQSGAVSAHNLASTVAVTQVSAVTSDAAGSSYSISGILGISSPADASKRKRDDPLQDSPLANGHSHSGRDFLRKQMRGELFTPQQLETTDYSAMASLAGGLEEMKNSLANQTGAELGSTVAGPQSYPLVSGRDLASTTLPGYPPHVPPTGQGSYSTPSLTGMVPGGDFSGSPYSHPQYSTYNESWRFANPSLLVFQQEYGSLLGSERAASSGLFPGQTPQPTGSPYYYSAATRGAGTAATATASAYDRH", "length": 396 }, "evidence": [ { "id": "A0AAA9T0H7", "url": "https://omabrowser.org/oma/group/A0AAA9T0H7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q02548-1", "protein_name": "Paired box protein Pax-5", "gene_name": "PAX5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH", "length": 391 }, "evidence": [ { "id": "A0AAA9T0H7", "url": "https://omabrowser.org/oma/group/A0AAA9T0H7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q02650-1", "protein_name": "Paired box protein Pax-5", "gene_name": "Pax5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLEKNYPTPRTIRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSPAARGAAPPAAATAYDRH", "length": 391 }, "evidence": [ { "id": "A0AAA9T0H7", "url": "https://omabrowser.org/oma/group/A0AAA9T0H7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "sensory organ development", "id": "GO:0007423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007423", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T0H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H7" }, { "id": "PS51057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Paired", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 142, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 285, 384 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 355, "end_pos": 357 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] } ]